]> Kelly Yang Darrell R. Abernethy Elizabeth Blair Qingping Liu Barry Smith Ling Wan Liwei Wang Keith Burkhart Luca Toldo Jiangan Xie Sydni Joubran Abra Guo "Asiyah" Yu Lin An ontology for the annotation of the adverse event domain. Bingjian Yang Desikan Jagannathan Izabela Birsanescu Edison Ong Mathias Brochhausen OAE: Ontology of Adverse Events OWL-DL Product version Vision Release; 1.1.356 Zuoshuang "Allen" Xiang Yongqun "Oliver" He (YH) Kevin Mo Sydni Joubran 2018-08-31 Meiu Wong Shelley Zhang Sirarat Sarntivijai Rebecca Racz Noemi Garg The Ontology of Adverse Eventsy (OAE) is a biomedical ontology in the domain of adverse events. OAE aims to standardize adverse event annotation, integrate various adverse event data, and support computer-assisted reasoning. OAE is a community-based ontology. Its development follows the OBO Foundry principles. Vaccine adverse events have been used as an initial testing use case. OAE also studies adverse events associated with the administration of drug and nutritional products, the operation of surgeries, and the usage of medical devices, etc. BFO OWL specification label BFO CLIF specification label editor preferred term example of usage has curation status definition editor note term editor definition editor alternative term definition source curator note imported from elucidation has associated axiom(nl) has associated axiom(fol) has axiom label Chinese translation YH, JX a chinese translation represents a chinese translation of the existing term. adverse event outcome The AE 'cough AE' has the 'label of AE outcome' of 'cough'; 'infection AE' has the 'label of AE outcom' of 'infection'. an annotation property that represents the label of an adverse event label of adverse event outcome Yongqun Oliver He, Jiangan Hardy Xie has_meddra_id has_alternative_id database_cross_reference has_exact_synonym has_narrow_synonym has_related_synonym in_subset label induced_by Yongqun He induced by a preceded_by relation that indicates that one process (e.g., an adverse event) is causally preceded by (induced by) another process (e.g., a medical intervention) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. induces the relation indicates that one process (e.g., a medical intervention) induces another process (e.g., an adverse event) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. This is an inverse relation of the term "induced_by". YH, AG role_of This is a tentative relation. We need to get this role from another ontology later. Oliver -- BFO 2.0 has this role 'is role of':: http://purl.obolibrary.org/obo/BFO_0000081 Once we get BFO 2.0, we can replace with this role. Oliver is evidence of This represents a relation between two adverse events AE1 and AE2. However, AE1 may be an evidence of another adverse event AE3, and a dfferent adverse event AE4 may also be an evidence of the same AE2. SS, YH, YL AE1 is_evidence_of AE2 if and only if: given an adverse event instance ae1 that instantiates class AE1 (e.g., electrocardiogram qt prolonged AE) and another adverse event instance ae2 that instantiates class AE2 (e.g., arrhythmia AE), both ae1 and ae2 are adverse events that are clinically observed after a medical intervention (at time t0) on the same patient. The presence of ae1 is supported by priori knowledge of medicine to imply the presence of ae2 with some probability P (P is NOT always 1, thus transitivity does not apply to is_evidence_of relation. AE1 is_evidence_of AE2 and AE2 is_evidence_of AE3 DOES NOT imply AE1 is_evidence_of AE3). The instance ae1 and ae2 are observed or detected at time t1 and t2, respectively. The biological onset time for ae1 or ae2 may occur before t1 or t2. The t1 and t2 can be the same time point or different time points. An electrocardiogram qt prolonged AE is_evidence_of arrhythmia AE; arrhythmia AE is_evidence_of cardiomyopathy AE; fever AE is_evidence_of inflammation AE; fever AE is_evidence_of viral infection AE; plural effusion AE is_evidence_of cardiac disorder AE. has participant quality an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased. Yongqun He This is a shortcut relation of the following full version: 'has participant' some (participant 'has quality' ) in: process 'has participant' some (participant 'has quality' some quality) adverse event occurs in a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. Yongqun He has participant undergoing Yongqun He A shortcut relation that represents the full path of ‘has participant’ some participant that ‘participates in’ some process. adverse event preceded by a specific 'preceded by' object property that has a domain of an adverse event. Yongqun He results in formation of example of usage: every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062); an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists. Chris Mungall has size Yongqun He A data property that indicates that a material entity has a particular size. has diameter in cm A 'has size' object property that indicates a material entity of round shape has a diameter of a particular length with the cm (centimeter) unit. A ulcer has a diameter in cm some specific decimal length Yongqun He adverse event Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'. YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740. YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623. AE YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'. a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events. WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068 The OAE official website is: http://www.oae-ontology.org/. WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm adverse reaction YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device. WEB: http://en.wikipedia.org/wiki/Adverse_event YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention. Yongqun He medical intervention medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States," Reference: http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis. YH WEB: http://wiki.answers.com/Q/What_is_medical_intervention causal adverse event He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. adverse effect an adverse event which is a causal adverse event, a pathological bodily process that is induced by a medical intervention. YH YH: the term "adverse effect" has the same meaning of "causal adverse event". YH: The term 'causal adverse event' has the same meaning as we previously defined as 'adverse event'. Reference: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing as a way to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. vaccine adverse event an adverse event that occurs after a vaccination. YH adverse drug event adverse drug reaction an adverse event that occurs after a drug administration YH, JX ADE ADR drug adverse event medical device adverse event an adverse event that is associated with the usage of a medical device. YH medical food adverse event an adverse event that is associated with eating a medical food. YH nutritional product adverse event YH an adverse event that is induced by consuming a nutritional product. dietary supplement adverse event an adverse event that is associated with consuming a dietary supplement. YH infant formula adverse event YH an adverse event that is associated with consuming an infant formula. drug administration a medical intervention where a patient is administered with a drug YH medical device usage for medical intervention YH a medical intervention that uses a medical device nutritional product usage consumption of nutritional product YH a medical intervention that uses a nutritional product dietary supplement consumption YH a nutritional product usage that consumes a dietary supplement consumption of infant formula a nutritional product usage that consumes infant formula YH consumption of medical food YH a nutritional product usage that consumes medial food X-ray result abnormal AE 10048065 an imaging investigation result abnormal AE that is characterized by an abnormal X-ray SS, YH, EB chest X-ray abnormal AE 10008499 SS, YH an X-ray result abnormal AE that has an outcome of an abnormality in chest X-ray test contusion AE 10050584 a haematoma AE that has an outcome of contusion. SS, YH Contusion is a type of relatively minor hematoma of tissue in which capillaries and sometimes venules are damaged by trauma, allowing blood to seep into the surrounding interstitial tissues. WEB: http://en.wikipedia.org/wiki/Bruise dry throat AE 10013789 SS, YH a digestive system AE which has an outcome of dry throat, which is a sensation of dryness in the throat. flushing AE 10016825 a skin discoloration AE which has an outcome of flushing, a sudden reddening of the face, neck, or upper chest SS, YH HPO: HP_0001033 SIDER: C0016382 脸红 CTCAE:E13771 NCIt:C26775 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003241.htm pain in extremity AE 10033425 CTCAE: E12512 SIDER: C0030196 NCIt: C78515 a pain AE where the pain reachs an extreme level. SS, YH, MW HPO: HP_0009763 postnasal drip AE 10036402 CTCAE: E13514 PDN NCIt: C78566 WEB: http://en.wikipedia.org/wiki/Post-nasal_drip Upper Airway Cough Syndrome SS, YH UACS a respiratory system AE which has an outcome of postnasal drip, which occurs when excessive mucus is produced by the nasal Mucosa. The excess mucus accumulates in the throat or back of the nose. cardiorenal syndrome AE 10068230 CRS a syndrome AE that is subclassified as five defined entities which represent clinical circumstances in which both the heart and the kidney are involved in a bidirectional injury and dysfunction via a final common pathway of cell-to-cell death and accelerated apoptosis mediated by oxidative stress. Types 1 and 2 involve acute and chronic cardiovascular disease (CVD) scenarios leading to acute kidney injury or accelerated chronic kidney disease. Types 2 and 3 describe acute and chronic kidney disease leading primarily to heart failure, although it is possible that acute coronary syndromes, stroke, and arrhythmias could be CVD outcomes in these forms of CRS. Finally, CRS type 5 describes a simultaneous insult to both heart and kidneys, such as sepsis, where both organs are injured simultaneously. WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030731/ SS, YH bursitis AE bursa inflammation SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001456/ A bursal disorder AE that has an outcome of the symptom of bursitis. musculoskeletal or connective tissue AE 10028395 an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue. YH, RR, JX WEB: http://www.cdc.gov/niosh/programs/msd/ musculoskeletal and connective tissue disorder AE A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture CTCAE: E13872 causal adverse event hypothesis CAE hypothesis YH a hypothesis about the causal relation between an adverse event and a medical intervention. This term can be used to hypothesize and evaluate the relation between a medical intervention (e.g., drug, vaccination) and case reports from an adverse event reporting system (e.g., VAERS). A statistical test can be used to accept or reject the hypothesis. bursal disorder AE a musculoskeletal system AE which has an outcome of bursal disorder YH influenza vaccine-induced adverse event YH YH: This term is just used as an example of vaccine induced adverse events. Specific vaccine-associated and vaccine-induced adverse events are now represented with the Ontology of Vaccine Adverse Events (OVAE).: http://www.violinet.org/ovae/. a vaccine adverse event that is induced by an influenza vaccine. KIV-induced adverse event an influenza vaccine adverse event that is induced by a killed influenza vaccine (KIV). YH KIV-induced GBS averse event in 1976-1977 VAERS statistical data analysis YH A KIV-induced AE that results in a GBS. There is little evidence to support a causal association between GBS and most vaccines. The evidence for a causal association is strongest for the swine influenza vaccine that was used in 1976-77. Studies of influenza vaccines used in subsequent years, however, have found small or no increased risk of GBS. Reference: http://www.ncbi.nlm.nih.gov/pubmed?term=19388722. Afluria-induced muscle ache AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf a muscle pain AE that is induced by Afluria influenza vaccine administration YH fatigue AE 10016256 10024264 SS, YH, MW NCIt: C3036; NCIt: C78416 CTCAE: E11098 (fatigue); CTCAE: E12709 (lethargy) lethargy AE HPO: HP_0003388 WEB: http://en.wikipedia.org/wiki/Fatigue_%28medical%29 lethargy is sometimes reported as an extreme fatigue: http://the-difference-between.com/lethargy/fatigue they are sometimes regarded as synonyms: https://www.nlm.nih.gov/medlineplus/ency/article/003088.htm SIDER: C0015672 a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. CSF culture negative AE SS, YH, EB a microbiology and serology investigation result abnormal AE that has an outcome of CSF culture negative. The negative result means no bacteria, viruses, or fungi grew in the laboratory dish. YH: The negative result is normal. It is not an AE. blood cell lab test abnormal AE SS, YH a lab test abnormal AE that has an outcome of an abnormal result in a blood cell lab test eosinophil percentage increased AE 10052222 YH, EB an eosinophil percentage abnormal AE that has an outcome of increased eosinophil percentage myocardial infarction AE 10028596 a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by an obstruction of the blood supply to the heart SIDER: C0027051 HPO: HP_0001658 SS 心肌梗塞 NCIt: C27996 WEB: http://www.ncbi.nlm.nih.gov/mesh/68009203 CTCAE: E10152 neutrophil count increased AE 10029368 YH SIDER: NA a neutrophil count abnormal AE that has an outcome of increased neutrophil count HPO: HP_0011991 procedural complication AE SS, YH post-procedural AE an adverse event that shows a complication that occurs after a medical procedure and is directly related to the precedure itself. procedural disorder AE procedure AE injury AE 10022116 SS, YH an injury and procedural complication AE which has an outcome of injury head injury AE 10019196 SS, YH an injury AE which has an outcome of head injury social behavior AE a behavior and neurological AE that has an abnormal outcome in social behavior SS, YH impaired work ability AE SS, YH a social behavior AE that has an outcome of impaired work ability injection-site allergic reaction AE 10022095 an allergy AE which has an outcome of injection-site allergic reaction myelitis transverse AE 10028527 WEB: http://en.wikipedia.org/wiki/Transverse_myelitis SS, YH a myelitis AE which has an outcome of myelitis transverse. Transverse myelitis (in Latin nomenclature: myelitis transversa) is a neurological disorder caused by an inflammatory process of the spinal cord, and can cause axonal demyelination. skin warm AE SS, YH a skin adverse even that has an outcome of warm skin nystagmus AE 10029864 眼球震颤 CTCAE:E12748 WEB: http://en.wikipedia.org/wiki/Nystagmus JX, LW, YH NCIt:C3282 Nystagmus AE is an eye AE that is a condition of involuntary eye movement, acquired in infancy or later in life, that may result in reduced or limited vision. Due to the involuntary movement of the eye, it is often called "dancing eyes". dermatitis bullous AE 10012441 HPO: HP_0011123 SS, YH SIDER: C0085932 Bullous pemphigoid is a skin disorder characterized by large blisters. a dermatitis AE that has an outcome of dermatitis bullous bullous pemphigoid AE hot flushes AE 10020407 HPO: HP_0008209 hot flashes AE hot flash AE hot flush AE SS, YH, MW SIDER: C0600142 a skin adverse event that is characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling. NCIt: C3109 CTCAE: E13781 Afluria-induced adverse event YH a KIV-induced adverse event that has an outcome of Afluria-induced adverse event tumor AE 10026865 YH, RR an adverse event that results in the outcome of a tumor. nodule AE tumour AE mass AE wheezing AE 10047924 NCIt:C78718 SS, YH, MW CTCAE:E13605 a respiratory system AE which has an outcome of wheezing, a high-pitched whistling sound made while breathing. WEB: http://www.mayoclinic.org/symptoms/wheezing/basics/definition/sym-20050764 weight bearing difficulty AE a behavior and neurological AE that has an outcome of weight bearing difficulty SS, YH weight bearing difficulty is a behavior AE that results in difficulty in managing the amount of weight a patient puts on the leg on which surgery has been performed. In general, it is described as a percentage of the body weight, because each leg of a healthy person carries the full body weight when walking, in an alternating fashion. WEB: http://en.wikipedia.org/wiki/Weight-bearing contraindication Yongqun He, Sirarat Sarntivijai, Mathias Brochhausen, William Hogan, ‎Philip E. Empey A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment. http://en.wikipedia.org/wiki/Contraindication incorrect drug dose administration a drug administration that uses incorrect drug dose YH Afluria-induced fever AE in child an Afluria-induced adverse event that has an outcome of Afluria-induced fever in child WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf YH Afluria-induced cough AE in child YH an Afluria-induced adverse event that has an outcome of Afluria-induced cough in child WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced injection site pain AE an Afluria-induced adverse event which has an outcome of Afluria-induced injection site pain YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced injection site redness AE an Afluria-induced adverse event that has an outcome of Afluria-induced injection site redness YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf Afluria-induced inject site swelling AE WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf YH an Afluria-induced AE that has an outcome of Afluria-induced inject site swelling Afluria-induced headache AE YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf an Afluria-induced adverse event that has an outcome of Afluria-induced headache systematic AE an adverse event that occurs systematically throughout the systemic circulation. This is different from local adverse event that is limited or a certain location. systematic adverse event URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction YH, JX pregnancy AE prenatal AE WEB: https://en.wikipedia.org/wiki/Prenatal_diagnosis YH, JX WEB: https://en.wikipedia.org/wiki/Complications_of_pregnancy A pregnancy, neonatal and perinatal AE that displays a disorder associated with pregnancy. adverse event incubation time a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event outcome appears. This is the time = 'time instant of an adverse event outcome observed' - 'time instant of medical intervention'. YH, XZ surgery AE a procedure complication AE that occurs after a surgery. surgery adverse event The key difference between a surgery and a procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. Technically speaking, a surgery is a specific type of procedure. A procedure is a broad general term that refers to any series of pre-defined steps that should be followed to achieve a desired result. Therefore, a “surgical procedure” is synonymous with a “surgery.” See more: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm. YH surgical procedure AE surgery 10042609 Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm YH, SS surgical procedure WEB: http://en.wikipedia.org/wiki/Surgery surgery-induced pressure ulcer AE surgery-induced bedsore AE YH a sugery adverse event that has an outcome of pressure ulcer. surgery-induced decubitus ulcer AE metabolism, endocrine or exocrine system AE 10027433 SS, YH, JX metabolism, endocrine, and exocrine system AE MP: 0005266 an adverse event which occurs in a metabolism process (including anabolism and catabolism), endocrine system, or exocrine system. clinical trial adverse event an adverse event that occurs in clinical trial. YH time at medical intervention YH time instant of medical intervention a termporal instant that is the time when a medical intervention occurs. time instant of an adverse event outcome observed YH a temporal instant that is the time when an outcome of an adverse event (e.g., fever) is observed. LAIV-induced adverse event an influenza vaccine adverse event that is induced by a live attenuated influenza vaccine (LAIV). YH FluMist-induced adverse event WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf an LAIV-induced adverse event that is caused by the FluMist LAIV. YH FluMist-induced runny nose AE a FluMist-induced adverse event that has an outcome of FluMist-induced runny nose YH FluMist-induced nasal congestion AE YH a FluMist-induced AE that has an outcome of FluMist-induced nasal congestion clinical laboratory test Rebecca Racz, Yongqun He WEB: http://labmed.ascpjournals.org/content/40/2/105.full medical laboratory test a planned process that is specifically a test conducted in a clinical laboratory. FluMist-induced sore throat AE in adult YH WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf A FluMist-induced AE that has an outcome of sore throat benign tumor AE YH a tumore AE that results in the outcome of a benign tumor. malignant tumor AE YH a tumore AE that results in the outcome of a malignant tumor. discomfort AE HPO: HP_0010832 a sensory capability AE that resuls in an uncomfortable feeling. YH SIDER: C0234215 female reproductive system AE 10038604 YH a reproductive system AE that occurs on the female side. male reproductive system AE a reproductive system AE that occurs on the male side. YH cardiac disorder AE 10007541 10061024 HPO: HP_0001627 a cardiovascular disorder AE that has a cardiac disorder outcome. SS, YH SIDER: C0018799 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/heart+disease Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23091623 vascular disorder AE 10047065 a cardiovascular disorder AE that has a vascular disorder outcome dermatitis AE 10012431 SIDER: C0011603 SS, YH HPO: HP_0011123 a skin adverse event that results in an inflammation of skin aspirin-induced adverse event a drug adverse event that is induced by aspirin. YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm Aspidrox-induced adverse event an aspirin-induced adverse event that is induced by the aspirin drug Aspidrox. aspirin-induced nausea AE YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm an aspirin-induced adverse event that has an outcome of nausea aspirin-induced vomiting AE an aspirin-induced adverse event that has an outcome of vomiting YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced stomach pain AE YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm an aspirin-induced adverse event that has an outcome of stomach pain aspirin-induced heartburn AE an aspirin-induced adverse event that has an outcome of heartburn YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm aspirin-induced rash AE an aspirin-induced adverse event that has an outcome of rash symptom. YH WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm therapeutic intervention a medical intervention that is used for therapeutic purpose YH causal adverse drug event YH a drug adverse event that is caused by a drug adiministration. Here a causal effect is established between the drug administration and the adverse event. adverse event induced by medical device a medical device adverse event that is induced by a medical device. There is a causal relation between the adverse event and the usage of a medical device. YH vaccine-induced adverse event an adverse event that is induced by a vaccination. YH surgery-induced adverse event a surgery adverse event that is caused by a surgery. YH nutritional product-induced adverse event YH a nutritional product adverse event that has a causal assocition with the usage of the nutritional product. influenza like illness AE 10016791 influenza like illness AE is an adverse event that has an outcome of a medical diagnosis of possible influenza or other illness causing a set of common symptoms acute respiratory infection, ARI, flu-like syndrome HPO: HP_0005376 WEB: http://en.wikipedia.org/wiki/Influenza-like_illness SS, YH MDR: 10022004 SIDER: C0521839 prediction of causal adverse event YH a prediction process that allows prediction of a causal adverse event induced by a medical intervention. prediction of causal vaccine adverse event a prediction of causal adverse event that is induced by a vaccination. YH fungal infection AE 10017533 HPO: HP_0002841 SIDER: C0026946 a pathogen infection adverse event that has an outcome of a fungal infection. YH prediction of causal drug adverse event YH a prediction of causal adverse event that is induced by a drug administration. prediction of causal medical device adverse event a prediction of causal adverse event that is induced by a usage of a medical device. YH prediction of causal surgery adverse event a prediction of causal adverse event that is induced by a surgery operation. YH determination of causal adverse event YH a planned process that leads to the identification of a causal relation between an existing adverse event and a medical intervention. determination of causal vaccine adverse event an identification of causal adverse event that is induced by a vaccination. YH determination of causal drug adverse event an identification of causal adverse event that is induced by a drug administration. YH determination of causal surgery adverse event YH an identification of causal adverse event that is induced by a surgery. determination of causal medical device adverse event YH an identification of causal adverse event that is induced by a usage of a medical device. intrinsic factor of causal adverse event an intrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event. YH extrinsic factor of causal adverse event an extrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event. YH extrinsic factor of adverse event a role that is extrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include environment, diet, smoking, alcohol use, herbal product, drug-drug interaction. YH intrinsic factor of adverse event YH a role that is intrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include: age, race, organ dysfunction, disease, pregrancy, lactation, gender, and genetics. environment factor of adverse event YH an extrinsic factor of adverse event that is from environment. age factor of adverse event YH an intrinsic factor of adverse event that is the age of a patient. race factor of adverse event YH an intrinsic factor of adverse event that is the race of a patient. gender factor of adverse event an intrinsic factor of adverse event that is the gender of a patient. YH organ dysfunction factor of adverse event an intrinsic factor of adverse event that is the organ dysfunction of a patient. YH disease factor of adverse event YH an intrinsic factor of adverse event that is a disease of a patient. pregrancy factor of adverse event YH an intrinsic factor of adverse event that is the pregrancy of a patient. lactation factor of adverse event an intrinsic factor of adverse event that is the lactation of a patient. YH genetics factor of adverse event an intrinsic factor of adverse event that is the genetics of a patient. YH adverse event reporting a planned process that reports an adverse event. YH vaccine adverse event reporting YH an adverse event reporting that is to report a vaccine adverse event. drug adverse event reporting YH an adverse event reporting that is to report a drug adverse event. causality of adverse event YH adverse event causality a quality that represents the level of causality between a medical intervention and an adverse event outcome. definite AE causality YH a causality level of AE that is definite. probable AE causality a causality level of AE that is probable. YH doubtful AE causality YH a causality level of AE that is doubtful. doubtful causality of adverse event possible AE causality a causality level of AE that is possible. Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20. YH potential causality of adverse event possible causality of adverse event medical device adverse event reporting YH an adverse event reporting that is to report a medical device adverse event. surgery adverse event reporting an adverse event reporting that is to report a surgery adverse event. YH determination of causal drug adverse event by Naranjo criteria S.R. Ahmed. Adverse drug event monitoring at the Food and Drug Administration. J. Gen. Intern. Med. 18 (2003) 57-60. YH an identification of causal drug adverse event that is based on the Naranjo criteria. determination of causal drug adverse event by DIPS J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680. an identification of causal drug adverse event that is based on the Drug Interaction Probability Scale (DIPS). The DIPS uses a series of questions relating to the potential drug interaction to estimate a probability score. As a comparison, the Naranjo scale has proved to be useful for assessing the causality of adverse events, particularly for single-drug adverse drug reactions. DIPS involves in two drugs: the drug that is affected (object drug) and the drug that causes the change to the object drug (precipitant drug). YH DIPS question J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680. YH an information content entity that lists one of 10 questions for the Drug Interaction Probability Scale (DIPS). DIPS question 1 DIPS question 1: Are there previous credible reports of this interaction in humans? YH Three answers: Yes (+1), No (-1), and Unk or NA (0) DIPS question 2 YH Three answers: Yes (+1), No (-1), and Unk or NA (0) DIPS question 2: Is the observed interaction consistent with the known interactive properties of precipitant drug? DIPS question 3 DIPS question 3: Is the observed interaction consistent with the known interactive properties of object drug? YH Three answers: Yes (+1), No (-1), and Unk or NA (0) DIPS question 4 DIPS question 4: Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS question 5 YH DIPS question 5: Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug? (if no dechallenge, use Unknown or NA and skip Question 6) Three answers: Yes (+1), No (-2), and Unk or NA (0) DIPS question 6 YH Three answers: Yes (+2), No (-1), and Unk or NA (0) DIPS question 6: Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug? DIPS question 7 YH DIPS question 7: Are there reasonable alternative causes for the event? Three answers: Yes (-1), No (+1), and Unk or NA (0) aConsider clinical conditions, other interacting drugs, lack of adherence, risk factors (eg, age, inappropriate doses of object drug). A NO answer presumes that enough information was presented so that one would expect any alternative causes to be mentioned. When in doubt, use Unknown or NA designation. DIPS question 8 DIPS question 8: Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction? Three answers: Yes (+1), No (0), and Unk or NA (0) YH DIPS question 9 DIPS question 9: Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug (other than drug concentrations from question 8)? YH Three answers: Yes (+1), No (0), and Unk or NA (0) DIPS question 10 DIPS question 10: Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased? Three answers: Yes (+1), No (-1), and Unk or NA (0) YH DIPS score Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Drug Interaction Probability Scale Yongqun He Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. an AE causality score that is represented as a score of the Drug Interaction Probability Scale (DIPS). Naranjo criterium Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. YH WEB: http://livertox.nih.gov/Narajo.html one of the Naranjo criteria that are frequently used for determination of causality for suspected adverse drug reactions (ADRs). Naranjo criterium 1 Three answers: Yes (+1), No (0), and Don't Know (0) YH DIPS question 1: Are there previous conclusive reports on this reaction? Naranjo criterium 2 DIPS question 2: Did the adverse reaction appear after the suspected drug was administered? Three answers: Yes (+2), No (-1), and Don't Know (0) YH Naranjo criterium 3 YH Three answers: Yes (+1), No (0), and Don't Know (0) DIPS question 3: Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? Naranjo criterium 4 YH DIPS question 4: Did the adverse reaction reappear when the drug was readministered? Three answers: Yes (+2), No (-1), and Don't Know (0) Naranjo criterium 5 Three answers: Yes (-1), No (+2), and Don't Know (0) DIPS question 5: Are there alternative causes that could on their own have caused the reaction? YH Naranjo criterium 6 YH Three answers: Yes (-1), No (+1), and Don't Know (0) DIPS question 6: Did the reaction reappear when a placebo was given? Naranjo criterium 7 DIPS question 7: Was the drug detected in the blood (or other fluids) in concentrations known to be toxic? YH Three answers: Yes (+1), No (0), and Don't Know (0) Naranjo criterium 8 YH Three answers: Yes (+1), No (0), and Don't Know (0) DIPS question 8: Was the reaction more severe when the dose was increased or less severe when the dose was decreased? Naranjo criterium 9 Three answers: Yes (+1), No (0), and Don't Know (0) YH DIPS question 9: Did the patient have a similar reaction to the same or similar drug in any previous exposure? Naranjo criterium 10 Three answers: Yes (+1), No (0), and Don't Know (0) YH DIPS question 10: Was the adverse event confirmed by any objective evidence? Naranjo ADR probability score Yongqun He a score of the Naranjo adverse drug reaction probability scaling SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful WEB: http://livertox.nih.gov/Narajo.html Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. causal adverse event probability an adverse event causal association score that represents a probability that an adverse event is caused (induced) by a medical intervention. CAE probability YH For an adverse event this is likely caused by a medical intervention, the causal adverse event (CAE) probabllity is in between 0 and 1. For a known causal adverse event, the CAE probabllity is 1. Alternatively, a CAE probability can be described as a scale that can go beyond the 0-1 range. For example, the Naranjo ADR probabililty score is a score that use scale with a wide range. sensory neuropathy AE a peripheral neuropathy AE which has an outcome of sensory neuropathy that involves damage to nerves of the peripheral nervous system. sensory neuropathy AE YH, AG distal sensory neuropathy AE a sensory neuropathy AE which has an outcome of distal sensory neuropathy that involves damage to distal sensory nerves of the peripheral nervous system. YH, AG chronic distal sensory neuropathy AE a distal sensory neuropathy AE that is chronic. YH, AG drug-induced neuropathy AE AG, YH a neuropathy AE that is induced by a drug administration https://medlineplus.gov/ency/article/000700.htm tremor AE 10044565 SS, YH SIDER: C0040822 WEB: http://www.nlm.nih.gov/medlineplus/tremor.html NCIt: C38038 HPO: HP_0001337 CTCAE: E12837 Tremor AE is a behavior and neurological AE that has an outcome of an involuntary trembling or quivering, and muscle contraction and relaxation. autonomic neuropathy AE 10061666 SIDER: C0259749 a neuropathy AE which shows symptoms due to the damage to the autonomic nerves. This damage disrupts signals between the brain and portions of the autonomic nervous system, such as the heart, blood vessels and sweat glands. This can cause decreased or abnormal performance of one or more involuntary body functions. WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy HPO: HP_0002270 UMLS CUI: C0259749 WEB: http://www.mayoclinic.org/diseases-conditions/autonomic-neuropathy/basics/definition/con-20029053 AG, YH motor neuropathy AE a peripheral neuropathy AE which is caused by a damage to motor neurons AG, YH polyneuropathy AE 10036105 WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html AG, YH, RR SIDER: C0152025 A peripheral neuropathy AE which is characterized by damage to more than one nerve HPO: HP_0001271 mononeuropathy AE 10062203 AG, YH a neuropathy AE which is characterized by isolated damage of a single nerve distal neuropathy AE AG, YH a peripheral neuropathy AE which affects extremities, such as, toes, fingers, hand and feet. axonal neuropathy AE WEB: http://www.livestrong.com/article/184686-distal-neuropathy-symptoms/ neuronopathy AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922643/ AG, YH a nervous system AE that affects the neuronal cell body mononeuritis AE 10027910 A neuritis AE which has an outcome of mononeuritis characterized by isolated inflammation of one nerve. AG, YH polyneuritis AE AG, YH A neuritis AE which has an outcome of polyneuritis characterized by isolated inflammation of many nerves. mononeuritis multiplex AE AG, YH a mononeuritis AE which has an outcome of mononeuritis multiplex which involves damage to at least two seperate unrelated nerve area. acute sensory neuropathy AE AG, YH a sensory neuropathy AE which has an outcome of acute sensory neuropathy that is characterized by rapid onset AE risk factor a disposition that represents a risk factor associated with the occurrence of an adverse event. AG, YH AE incidence rate AG, YH WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf A data item that is calculated as the number of patients realized with an adverse event beginning in an interval divided by the number of patients taking the same medical intervention within the same interval. The incidence thus indicates the number of newly occurring events over time. causal adverse drug event due to drug-drug interaction 10013710 YH, LT WEB: http://medical-dictionary.thefreedictionary.com/drug+interaction a causal adverse drug event that is induced by a drug-drug interaction. causal adverse drug event due to food-drug interaction a causal adverse drug event that is induced by a food-drug interaction. YH, LT causal adverse drug event due to genetic predisposition a causal adverse drug event that is induced bygenetic predisposition. YH, LT causal adverse drug event due to SNP a causal adverse drug event due to genetic predisposition that is specifically induced by SNP. YH, LT circulatory shock AE 10040560 physiological shock AE Here is the Kumar and Parrilo definition of shock: "The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury". Reference: Kumar A, Parillo JE. Shock: pathophysiology, classification and approach to management. In: Parrillo JE, Parrillo JE, Bone RC (eds): Critical care medicine: Principles of diagnosis and management. Mosby: Toronto, 1995, pp 371-420. 休克 a cardiovascular disorder AE that is a result of insufficient blood flow throughout the body. Shock often accompanies severe injury or illness. WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000039.htm shock WEB: http://en.wikipedia.org/wiki/Shock_%28circulatory%29 WEB: http://njcc.nl/sites/default/files/pdf/review-2_1.pdf (Lima A. Circulatory shock and peripheral circulatory failure: a historical perspective. Netherlands Journal of Critical Care. 2014. 18:6. 14-18) Circulatory shock is not related to the emotional state of shock. dementia AE 10012272 HPO: HP_0000726 WEB: https://en.wikipedia.org/wiki/Dementia a psychiatric disorder AE that has an outcome of a loss of brain function and causes a long term and often gradual decrease in the ability to think and remember such that a person's daily functioning is affected. 痴呆 Dementia is a loss of brain function that occurs with certain diseases or pathological processes. YH, MW SIDER: C0497327 thrombosis AE 10043607 SS, YH, MW SIDER: C0040053 HPO: HP_0004419 血栓症; 血栓生成 A vascular disorder AE that results in the presence of blood clot along the wall of a blood vessel, frequently causing vascular obstruction. Some authorities differentiate thrombus formation from simple coagulation or clot formation. cell death AE 10057248 HPO: HP_0010885 SIDER: C0007587 SS, YH a metabolic disorder AE that has an outcome of cell death. respiratory tract neoplasm AE 10029107 a respiratory system AE which has an outcome of some respiratory tract neoplasm. YH competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A biochemical inhibitor role YH, AG, YL agonist role WEB: http://en.wikipedia.org/wiki/Agonist YH, AG, YL antagonist role In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors. WEB: http://en.wikipedia.org/wiki/Receptor_antagonist YH, AG, YL phlebitis AE 10034879 CTCAE:E13815 SIDER: C0031542 NCIt:C38003 HPO: HP_0004419 an inflammation AE that shows the result of an inflammation located in a vein, usually in the legs. YH, MW pancreatitis AE 10033645 10033646 HPO: HP_0001733 YH, MW SIDER: C0030305 NCIt: C3306 CTCAE: E10930 a liver, biliary, and pancreatic AE that has an outcome of pancreatitis. apoptosis AE 10059512 SS, YH a cell death AE that has an outcome of apoptosis. necrosis AE SS, YH SIDER: C0027540 HPO: HP_0003713 a cell death AE that has an outcome of necrosis ischemia AE 10061255 HPO: HP_0002597 ischaemia AE SIDER: C0022116 SS, YH A cardiovascular disorder AE that results in Insufficient blood supply for the need of a part of the body, usually as a result of a disease of the blood vessels supplying that part. Note: also spelt ischemia. hair, skin or nail AE YH, SS, JX an adverse event that occurs in hair, skin, or nail. hair, skin, and nail AE hair AE YH, SS a hair, skin, and nail AE that occurs in hair. nail AE a hair, skin, and nail AE that occurs in nail. YH, SS endocrine system AE 10014698 a metabolism, endocrine, and exocrine system AE that occurs in endocrine system. YH, SS exocrine system AE YH, SS a metabolism, endocrine, and exocrine system AE that occurs in exocrine system congenital AE 10010331 an adverse event that displays a congential and genetic disorder. congenital abnormality AE YH, SS paresis AE 10033800 WEB: https://en.wikipedia.org/wiki/Paresis SIDER: C0030552 HPO: HP_0008153 局部麻痹 Neurologists use the term paresis to describe weakness, and plegia to describe paralysis in which all voluntary movement is lost. (Reference: https://en.wikipedia.org/wiki/Paresis) a muscular weakness AE that shows weakness or inability to move a body part, often used to describe a neurologic condition. cystic fibrosis AE 10011762 SIDER: C0010674 HPO: HP_0006552 WEB: http://medical-dictionary.thefreedictionary.com/cystic+fibrosis YH a syndrome AE that has an outcome of cystic fibrosis, an inherited disease that affects the lungs, digestive system, sweat glands, and male fertility. hyperplasia AE HPO: HP_0010279 YH, SS a tumore AE that results in the outcome of hyperplasia, an abnormal increase in the number of normal cells in normal arrangement in an organ or tissue, which increases its volume. SIDER: C0020507 abdominal AE an adverse event that displays a disorder in abdomen. YH, SS genetic AE genetic disorder AE an adverse event that results in genetic disorder. YH, SS hepatitis AE HPO: HP_0006562 a liver, biliary, and pancreatic AE that has an outcome of hepatitis. YH SIDER: C0019158 ulcer AE an adverse event that displays an outcome of ulcer. SIDER: C0041582 HPO: HP_0005229 YH, SS fistula AE 10067143 SIDER: C0016169 YH, SS a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body. WEB: http://medical-dictionary.thefreedictionary.com/fistula HPO: HP_0010294 extravasation AE 10015866 YH, SS an abnormal fluid regulation AE which has an outcome of extravasation, a discharge or escape, as of blood, from a vessel into the tissues. WEB: http://medical-dictionary.thefreedictionary.com/extravasation sclerosis AE YH, SS an adverse event that displays an outcome of an sclerosis, the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue. inconsolable crying AE 10065283 a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient YH unusual high-pitched crying AE YH a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient prolonged crying AE a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient YH bradycardia AE 10006093 WEB: http://en.wikipedia.org/wiki/Bradycardia HPO: HP_0001662 WEB: http://medical-dictionary.thefreedictionary.com/bradycardia SIDER: C0428977 a decreased heart rate AE that results in a resting heart rate of under 60 beats per minutes (BPM). prenatal, perinatal or neonatal disorder AE 10036585 pregnancy, neonatal and perinatal disorder AE an adverse event that displays a disorder associated with child birth, newborn infant, or an infant. YH, JX administration of ineffective drug an errored drug administration where a patient is administered with an ineffective drug YH administration of drug with decreased effectiveness an errored drug administration where a patient is administered with an ctive drug with decreased effectiveness YH aplenzin-induced adverse event YH a bupropion-induced adverse event that is induced by aplenzin administration drug overdose administration an errored drug administration where a patient is administered with a drug above the therapeutic level YH administration of drug with omitted dose YH an errored drug administration where a patient is administered with an drug without knowing the dose used. drug resistance a quality that represents resistance of a patient to a drug. YH medical intervention site AE 10003055 application site reaction an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site). YH medical intervention site a site that is used for a medical intervention YH administration of drug stored in capsule with physical defect an errored drug administration where a patient is administered with an drug stored in capsule with physical defect YH administration of drug with wrong technique 10064353 YH an errored drug administration where a patient is administered with an drug with wrong technique administration of drug with incorrect route 10064304 a drug administration where a patient is administered with an drug with incorrect route YH neonatal AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with newborn infant or an infant. YH perinatal AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with childbirth YH errored medication 10027091 YH a medical intervention that has an errored medication errored drug administration 10064355 a medical intervention that has errored drug medication SS, YH radiotherapy YH a therapeutic intervention that uses radiation arterial disorder AE arterial disease AE SS SIDER: C0852949 a vascular disorder AE that affects the artery HPO: HP_0002620 peripheral arterial disease AE 10067825 SIDER: C1704436 an artery disorder AE that is characterized by a narrowing of the blood vessels outside of the heart. WEB: http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=peripheral+arterial+disease peripheral artery disease AE HPO: HP_0004950 SS peripheral artery disorder AE psoriasis AE 10037153 an autoimmune disease AE that shows a symptom of dry red patches on the skin. HPO: HP_0003765 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/psoriasis SIDER: C0033860 WEB: https://en.wikipedia.org/wiki/Psoriasis cumulative distal sensory neuropathy AE a distal sensory neuropathy AE characterized by an increase in degree (cumulative) AG, YH stress AE YH a behavior and neurological AE that has an outcome of stress in a patient abdominal abscess AE 10060921 DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000212.htm an abscess AE that has an outcome of a pocket of infected fluid and pus located inside the abdominal cavity abdominal discomfort AE 10000059 HPO: HP_0002027 SIDER: C0232487 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Abdominal+discomfort a discomfort AE that has an outcome of a stomach ache abdominal distension AE 10000060 NCIt: C78161 a sensory capability AE that results in a sensation of elevated abdominal pressure and volume DJ, SS, YH HPO: HP_0003270 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0003609/ SIDER: C0000731 CTCAE: E10456 abdominal sepsis AE 10058040 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001687/ DJ, SS, YH a sepsis AE that has an outcome of sepsis in the abdominal area abdominal wall abscess AE 10000099 an abdominal abscess AE that has an outcome of a collection of pus in the abdominal wall, causes inflammation DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002329/ obsolete: behavior AE 10061422 HPO: HP_0000708 DJ, SS, YH 12/19/2015: This term became obsolete since its meaning can be quite confusing. "behavior AE" is now considered as the synonym of 'behavioral and neurological AE'. abnormal behaviour AE abnormal behavior AE behavioral AE SIDER: C0233514 a behavioral AE that results in uncharacteristic behaviors abnormal dreams AE 10000125 DJ, SS, YH a behavioral and neurological AE that results in odd dreams abortion induced AE 10000220 DJ, SS, YH an abortion AE that has an outcome of expulsion of a fetus from the uterus brought on intentionally by medication or instrumentation WEB: http://medical-dictionary.thefreedictionary.com/induced+abortion abortion spontaneous AE 10000234 HPO: HP_0005268 an abortion AE that results in a miscarriage WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002458/ DJ, SS, YH SIDER: C0000786 acne AE 10000496 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/acne SIDER: C0702166 acne vulgaris AE a skin AE that is characterized by pimples generally on the face, chest and back, caused by clogging of the pores HPO: HP_0001061 acquired immunodeficiency syndrome AE 10000565 WEB: http://www.nlm.nih.gov/medlineplus/hivaids.html SIDER: C0001175 a immune system disorder AE that is caused by the HIV virus DJ, SS, YH HPO: HP_0002721 activated partial thromboplastin time prolonged AE 10000636 DJ, SS, YH HPO: HP_0003645 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm CTCAE: E12073 NCIt: C27028 a hematopoietic system AE that has an outcome of a prolonged time taken for blood to clot. The partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. PTT measures the efficacy of the comon coagulation pathways and helps tell if bleeding or clotting problems exist. SIDER: C0853223 acute graft versus host disease in intestine AE 10066264 DJ, SS, YH a digestive system AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the intestine attack the transplant recipient's body WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm acute graft versus host disease in skin AE 10066262 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm a skin AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the skin attack the transplant recipient's body DJ, SS, YH acute lymphocytic leukemia AE 10000846 a hematopoietic system AE that has an outcome of a type of acute leukemia, characterized by anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, and bone pain DJ, SS, YH SIDER: C0023449 WEB: http://medical-dictionary.thefreedictionary.com/Blast+count acute lymphocytic leukaemia AE HPO: HP_0006721 acute lymphocytic leukemia recurrent AE 10063620 WEB: http://marrow.org/Patient/Disease_and_Treatment/About_Your_Disease/ALL/Acute_Lymphoblastic_Leukemia_(ALL).aspx acute lymphocytic leukaemia recurrent AE a hematopoietic system AE that has an outcome of the reoccurance of fast-growing cancer of the white blood cells where abnormal blasts do not fight infections after a period of remission DJ, SS, YH acute myeloid leukemia AE 10000880 a hematopoietic system AE that has an outcome of cancer in the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells DJ, SS, YH acute myeloid leukaemia AE SIDER: C0023467 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/ HPO: HP_0004808 acute myeloid leukemia recurrent AE 10059034 an acute myeloid leukemia AE that shows an recurrence of acute myeloid leukemia DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/ acute myeloid leukaemia recurrent AE acute pulmonary edema AE 10001029 DJ, SS, YH HPO: HP_0100598 acute pulmonary oedema AE WEB: http://medical-dictionary.thefreedictionary.com/Acute+pulmonary+edema SIDER: C0155919 a lung disorder AE that has the outcome fluid accumulation in the air spaces and parenchyma of the lungs with rapid onset acute respiratory distress syndrome AE 10001052 SIDER: C0035222 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001164/ a respiratory distress AE that has an outcome of a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood DJ, SS, YH HPO: HP_0002093 acute respiratory failure AE 10001053 HPO: HP_0002093 DJ, SS, YH, MW SIDER: C0264490 a lung disorder AE that has an outcome of a condition in which not enough oxygen passes from the lungs into the blood, with rapid onset WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/rf/ adams-stokes syndrome AE 10001115 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518479/ a syncope AE that results in sudden episodes of fainting and sometimes seizures DJ, SS, YH adenomyosis AE 10056268 DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002481/ a reproductive system AE that results in the thickening of the walls of the uterus. This ccurs when endometrial tissue, which normally lines the uterus, moves into the outer muscular walls of the uterus. endrometriosis interma AE adenovirus infection AE 10060931 a viral infection that occurs in the respiratory system and has an outcome of viral infection by nonenveloped icosahedral viruses causing illness in the respiratory system WEB: http://medical-dictionary.thefreedictionary.com/Adenovirus+Infections DJ, SS, YH SIDER: C0001486 HPO: HP_0004429 adrenal neoplasm AE 10061588 WEB: http://www.ncbi.nlm.nih.gov/pubmed/22486993 DJ, SS, YH a tumor AE that results in an abnormal number of cells proliferating on the kidney(s) adrenal suppression AE 10001382 DJ, SS, YH an endocrine system AE that results in the suppression of the functions of the adrenal glands aggression AE 10001488 SIDER: C0001807 HPO: HP_0000718 a behavior and neurological AE that results in an increase in hostile behavior DJ, SS, YH agranulocytosis AE 10001507 HPO: HP_0001913 SIDER: C0001824 a hematopoietic system AE that has an outcome of acute leukopenia, or lowered white blood cell count, most commonly of neutrophils causing neutropenia in circulating blood WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001295.htm 粒性白血球缺乏症 JX, DJ, SS, YH air embolism AE 10001526 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23295634 an embolism AE that is caused by an air bubble in the vessel DJ, SS, YH alanine aminotransferase level abnormal AE 10001547 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 DJ, SS, YH a liver related investigation result abnormal AE that has an outcome of an abnormal blood level of alanine aminotransferase alanine aminotransferase level decreased AE 10001549 an alanine aminotransferase level abnormal AE that has an outcome of a decrease in alanine aminotransferase level in body WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 DJ, SS, YH, EB alanine aminotransferase level increased AE 10001551 DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615 NCIt: C26948 CTCAE: E12077 an alanine aminotransferase level abnormal AE that has an outcome of elevated levels of alanine transaminase, an enzyme most commonly found in the liver alcoholic liver disease AE 10001627 DJ, SS, YH a liver/biliary system AE that is characterized by liver disease caused by the patient's alcoholic activity altered state of consciousness AE 10001854 DJ, SS, YH a behavior and neurological AE that has an outcome of significantly different waking beta wave state WEB: http://www.ncbi.nlm.nih.gov/pubmed/20182997 amenorrhoea AE 10001928 HPO: HP_0000141 DJ, SS, YH SIDER: C0002453 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21942684 a female reproductive system AE that is characterized by the absence of menstrual period in a woman of reproductive age amniotic fluid volume decreased AE 10063356 WEB: http://www.ncbi.nlm.nih.gov/pubmed/22039031 an abnormal fluid regulation AE that results in a decreased volume of amniotic fluid during pregnancy DJ, SS, YH anal fissure AE 10002153 an anus AE that has an outcome of a split or tear in the mucosa lining the lower rectum WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002116/ DJ, SS, YH SIDER: C0016167 HPO: HP_0004378 anal ulcer AE 10002180 CTCAE: E10496 WEB: http://www.ncbi.nlm.nih.gov/pubmed/17073250 DJ, SS, YH an ulcer AE that has an outcome of an ulcer in the anal cavity NCIt: C79536 anastomotic leak AE 10050456 DJ, SS, YH a vascular disorder AE that has an outcome of a leakage at the site of the intersection of two blood vessels WEB: http://www.ncbi.nlm.nih.gov/pubmed/23122582 angina pectoris AE 10002383 WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Angina-Pectoris-Stable-Angina_UCM_437515_Article.jsp# a cardiac disorder AE that is stable and shows the symptom of a chest pain due to ischemia of the heart stable angina AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723 HPO: HP_0001681 SIDER: C0002962 DJ, SS, YH angina unstable AE 10002388 DJ, SS, YH a angina AE that is unstable and has an outcome of a condition in which the heart doesn't get enough blood flow through the blood vessels of the heart muscle, may lead to heart attack. WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001250/ HPO: HP_0001681 SIDER: C0002965 antiphospholipid antibodies positive AE 10048678 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23231732 DJ, SS, YH, EB an immunology and allergy investigation result abnormal AE that is characterized by antibodies present that are against cell-membrane phospholipids that provoke blood clots anuria AE 10002847 DJ, SS, YH SIDER: C0003460 HPO: HP_0100519 WEB: http://medical-dictionary.thefreedictionary.com/anuria a urinary system AE that has an outcome of the absence of urine formation aortic disorder AE 10058648 a vascular disorder AE that results in a condition affecting the aorta and aortic valves DJ, SS, YH HPO: HP_0001679 WEB: http://www.rightdiagnosis.com/medical/aorta_disorder.htm SIDER: C0003493 aortic valve incompetence AE 10002915 DJ, SS, YH WEB: http://www.rightdiagnosis.com/a/aortic_valve_incompetence/intro.htm a cardiac valve disease AE that has an outcome of inability of the aortic valve to function effectively SIDER: C0003504 HPO: HP_0001659 aplasia AE 10002961 DJ, SS, YH HPO: HP_0010515 SIDER: C0243065 WEB: http://www.ncbi.nlm.nih.gov/pubmed/737831 a congenital abnormality AE with an outcome of defective development or congenital absense of an organ or tissue aplastic anaemia AE 10002967 再生障碍性贫血 aplastic anemia DJ, SS, JX, YH Aplastic anaemia AE is an anemia AE that occurs when the bone marrow, and the blood stem cells that reside there are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). SIDER: C0002874 HPO: HP_0001915 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23292240 allergic brochospasm AE that requires treatment in emergency URL: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm URL: https://en.wikipedia.org/wiki/Bronchospasm a serious AE that is due to an allergic brochospasm, which causes a serious problem with breathing and requires treatment in an emergency room. YH, JX application site hypersensitivity AE 10063683 a hypersensitivity AE that occurs at the site of an application of a medical intervention (e.g., drug administration or vaccination). DJ, SS, YH application site infection AE 10049041 an infection AE that occurs at the site of drug application DJ, SS, YH arterial hemorrhage AE 10060964 a hemorrhage AE that has an outcome of bleeding in the arteries arterial bleeding AE DJ, SS, YH arterial haemorrhage AE CSF protein increased AE 10011575 SS, YH CSF protein increased AE is an abnormal cerebrospinal fluid production that results in and increase in blood level CSF protein CSF test result abnormal AE 10059703 WEB: www.nlm.nih.gov/medlineplus/ency/article/003428.htm a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of an abnormal result in the cerebrospinal fluid (CSF) collection test that examines the fluid that surrounds the brain and spinal cord This should be inferred as a "AE: lab test abnormal". SS, YH, EB Henoch-Schonlein purpura AE 10019617 WEB: http://en.wikipedia.org/wiki/Henoch-Schonlein_purpura SS, YH Henoch-Schonlein purpura AE is a purpura AE, a systemic vasculitis (inflammation of blood vessels) characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney. This results from some allergic response, allergic purpura, anaphylactoid purpura, vascular purpura SIDER: C0034152 HPO: HP_0000979 abasia AE 10049460 HPO: HP_0002540 a movement disorder AE that has an outcome of abasia, a movement disorder that results in and inability to walk due to impaired muscle coordination SIDER: C0877217 SS, YH WEB: http://en.wikipedia.org/wiki/Abasia abdominal pain upper AE 10000087 SIDER: C0232492 SS, YH HPO: HP_0002027 a stomach pain AE that is observed in upper stomach ageusia AE 10001480 WEB: http://en.wikipedia.org/wiki/Ageusia a behavior and neurological AE that has an outcome of loss of taste functions of the tongue, particularly the inability to detect sweetness, sourness, bitterness, saltiness, and umami (the taste of monosodium glutamate). SS, YH chronic sensory neuropathy AE a sensory neuropathy AE that has an outcome of chronic sensory neuropathy characterized by being persistent or long-lasting in nature AG, YH anosmia AE 10002653 SS, YH SIDER: C0003126 WEB: http://en.wikipedia.org/wiki/Olfaction HPO: HP_0010632 a behavior and neurological AE that has an outcome of a lack of functioning olfaction, an inability to perceive odors anxiety AE 10002855 a psychiatric disorder AE that has an outcome of a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry. HPO: HP_0000739 CTCAE: E12883 SIDER: C0003467 SS, YH WEB: http://en.wikipedia.org/wiki/Anxiety NCIt: C26696 atrial flutter AE 10003662 HPO: HP_0004749 SS NCIt: C51224 CTCAE: E10087 auricular flutter SIDER: C0004239 WEB: http://medical-dictionary.thefreedictionary.com/atrial+flutter AF an arrhythmia AE that is characterized by rapid regular atrial contractions occurring usually at rates between 250 and 400 per minute and often producing saw-tooth waves in an electrocardiogram. balance disorder AE 10049848 a behavior and neurological AE that has an outcome of a disturbance that causes an individual to feel unsteady, giddy, woozy, or have a sensation of movement, spinning, or floating. HPO: HP_0002141 SS, YH SIDER: C0575090 WEB: http://en.wikipedia.org/wiki/Balance_disorder blister AE 10005191 HPO: HP_0008066 blister AE is a skin adverse event that results in a small pocket of fluid within the upper layers of the skin SS, YH WEB: http://en.wikipedia.org/wiki/Blister SIDER: C0005758 cellulitis AE 10007882 HPO: HP_0003553 cellulitis AE is an inflammation AE that is a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin WEB: http://en.wikipedia.org/wiki/Cellulitis SIDER: C0007642 SS, YH cold sweat AE SS, YH a behavior and neurological AE that has an outcome of a type of perspiration usually associated with anxiety or fear WEB: http://en.wikipedia.org/wiki/Cold_sweat convulsion AE 10010904 convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body HPO: HP_0001250 WEB: http://en.wikipedia.org/wiki/Convulsion SIDER: C0009951 SS, YH difficulty in walking AE SS, YH a movement disorder AE that has an outcome of difficulty in walking properly dysgeusia AE 10013911 WEB: http://en.wikipedia.org/wiki/Dysgeusia NCIt:C28145 HPO: HP_0000223 SS, YH, MW a behavior and neurological AE that has an outcome of distortion of the sense of taste SIDER: C0013378 CTCAE:E12643 dyskinesia AE 10013916 SIDER: C0013384 HPO: HP_0100660 WEB: http://en.wikipedia.org/wiki/Dyskinesia SS, YH dyskinesia is a movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements a movement disorder AE that has an outcome of dyskinesia dyspnea AE 10013963 10013968 SS, YH WEB: http://en.wikipedia.org/wiki/Dyspnoea HPO: HP_0002094 UMLS CUI: C0013404 MedDRA: 10013968 is for "dyspnoea"; MedDRA: 10013963 is for "dyspnea". NCIt: C2998 SIDER: C0013404 呼吸困难 CTCAE: E13368 dyspnoea AE is an abnormal respiration AE debilitating symptom that is the experience of unpleasant or uncomfortable respiratory sensations, shortness of breath, air hunger dyspnoea AE electromyogram result abnormal AE 10014431 SS, YH, EB a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of abnormal activity in skeletal muscles evaluted and measured by electromyography WEB: http://en.wikipedia.org/wiki/Electromyography eye irritation AE 10015946 SS, YH SIDER: C0235266 HPO: HP_0000478 WEB: http://www.freemd.com/eye-irritation/ eye irritation AE is an eye disorder AE that results in mild eye redness, itching, or tearing eye pruritus AE 10052140 SIDER: C0022281 eye pruritus AE is a pruritus AE (an unpleasant sensation that evokes the desire or reflex to scratch) at the eye area HPO: HP_0000989 SS, YH glomerulonephritis AE glomerular nephritis AE SS, YH HPO: HP_0000099 glomerulonephritis AE is a kidney disorder AE that results in a renal disease that is characterized by inflammation of the glomeruli, or small blood vessels in the kidneys. WEB: http://en.wikipedia.org/wiki/Glomerulonephritis SIDER: C0017658 bundle branch block right AE 10006582 SS right bundle branch block HPO: HP_0011712 SIDER: C0085615 RBBB WEB: http://medical-dictionary.thefreedictionary.com/right+bundle+branch+block A conduction system disorder AE that is a condition in which the electrical impulse from the bundle of His to the ventricles is delayed or fails to conduct along the right bundle branch, resulting in right ventricular depolarization by cell-to-cell conduction spreading from the interventricular septum and left ventricle to the right ventricle–ie, slow and uncoordinated Natural history Surgically induced RBBB has few acute hemodynamic consequences and a generally benign course long term; rarely, progression to complete heart block and sudden death occur, especially if accompanied by major His-Purkinje system–eg, left anterior hemiblock, first-degree AV block–injury; tetralogy of Fallot repair with an RBBB and a markedly prolonged QRS duration >180 ms have an ↑ risk for ventricular arrhythmias and sudden death. conduction system disorder AE 10000032 10010276 a cardiac disorder AE of the electrical conduction system that controls the heart rate, generates and conducts electrical impulses throughout the muscle of the heart, stimulating the heart to contract and pump blood. conduction disorder AE NCIt: C78245 CTCAE: E10114 WEB: http://www.medterms.com/script/main/art.asp?articlekey=8407 SS cardiac conduction disorder AE hypoesthesia AE 10020937 WEB:http://medguides.medicines.org.uk/document.aspx?name=hypoaesthesia a sensory capability AE that has an outcome of hypoaesthesia, meaning that skin loses some of its sensitivity to pain or touch HPO: HP_0010830 SIDER: C0020580 hypoaesthesia AE SS, YH disesthesia AE arterial thrombosis AE 10003178 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23236330 a thrombosis AE that has an outcome of a blood clot within an artery HPO: HP_0004420 SIDER: C0151942 [SS] Per DRA and KKB's comment, arterial thrombosis may also be characterized as an embolism. DJ, SS, YH influenza AE SIDER: C0021400 SS, YH a viral infection AE that demonstrates an influenza viral infection. Influenza is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals WEB: http://en.wikipedia.org/wiki/Influenza HPO: HP_0005376 MDR: 10022000 arteriosclerosis coronary artery AE 10003211 SIDER: C0010054 WEB: http://medical-dictionary.thefreedictionary.com/Coronary+Arteriosclerosis a coronary artery disease AE with the outcome hardening of the coronary artery due to a build up of waxy plaque on the inside of blood vessels HPO: HP_0004929 DJ, SS, YH injected limb mobility decreased AE SS, YH injected limb mobility decreased AE is a mobility decreased AE that occurs in the limb in which injection is administered injection-site hematoma AE 10022066 injection-site haematoma AE WEB: http://medical-dictionary.thefreedictionary.com/hematoma http://en.wikipedia.org/wiki/Hematoma SS, YH a haematoma AE that has an outcome of injection-site haematoma, which results in a collection of blood outside the blood vessels at the physical area of injection injection-site induration AE WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site SS, YH injection-site pruritus AE 10022093 WEB: http://medical-dictionary.thefreedictionary.com/pruritus SS, YH injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection WEB: http://en.wikipedia.org/wiki/Itch injection-site rash AE SS, YH WEB: http://en.wikipedia.org/wiki/Rash injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site injection-site warmth AE injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site SS, YH joint swelling AE 10023232 SIDER: C0152031 SS, YH HPO: HP_0005833 A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm kidney AE 10038428 abnormal renal function AE SS, YH an adverse event that occurs in kidney. lacrimation increased AE 10023644 HPO: HP_0009926 WEB: http://www.medterms.com/script/main/art.asp?articlekey=6199 SIDER: C0152227 SS, YH a behavior and neurological AE that has an outcome of an increase in production, secretion, and shedding of tears WEB: http://en.wikipedia.org/wiki/Tears lip swelling AE 10024570 SIDER: C0240211 WEB: http://en.wikipedia.org/wiki/Swelling_%28medical%29 HPO: HP_0000159 lip swelling AE is an edema (swelling) AE that results in enlargement or protuberance in the lip SS, YH lymphadenitis AE SS, YH HPO: HP_0002840 SIDER: C0024205 WEB: http://en.wikipedia.org/wiki/Lymphadenopathy A lymphadenopathy AE that results in swollen/enlarged lymph nodes mobility decreased AE 10048334 SS, YH SIDER: C0700572 mobility decreased AE is a nervous system AE that results in difficulty in movement leading to less ability to move part(s) of body HPO: HP_0006217 muscular weakness AE 10028372 HPO: HP_0001324 a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength). SS, YH SIDER: C0151786 WEB: http://en.wikipedia.org/wiki/Muscular_weakness musculoskeletal stiffness AE 10052904 SIDER: C0948525 SS, YH a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton HPO: HP_0003552 nasal congestion AE 10028735 WEB: http://en.wikipedia.org/wiki/Nasal_congestion nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels SIDER: C0027424 SS, YH HPO: HP_0001742 NCIt: C78500 CTCAE: E13450 nasopharyngitis AE a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system SIDER: C0027441 SS, YH common cold AE WEB: http://en.wikipedia.org/wiki/Nasopharyngitis a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system HPO: HP_0002087 peripheral neuropathy AE 10029331 an neuropathy AE that results in a damage to the peripheral nervous system (PNS, outside the brain and spinal cord), the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body. neuropathy peripheral AE WEB: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm SS, YH WEB: http://en.wikipedia.org/wiki/Peripheral_neuropathy ocular hyperemia AE 10030041 ocular hyperaemia AE SS, YH WEB: http://www.med.miami.edu/news/view.asp?id=259 ocular hyperaemia AE is an eye disorder AE that results in severe redness and irritation of the eyes oropharyngeal pain AE 10068319 a pain AE that has an outcome of oropharyngeal pain HPO: HP_0010833 oropharyngeal pain is a pain in oral airway WEB: http://en.wikipedia.org/wiki/Oropharyngeal_airway SIDER: C2363731 SS, YH otitis media AE 10033078 NCIt: C34885 SIDER: C0029882 SS, YH an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection CTCAE: E11477 WEB: http://en.wikipedia.org/wiki/Otitis_media HPO: HP_0008623 pericarditis AE 10034484 HPO: HP_0001701 SS, YH an inflammation AE that has an outcome of pericaditis, which is a cardiovascular disorder that results in a condition in which the sac-like covering around the heart (pericardium) becomes inflamed NCIt: C34915 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000182.htm CTCAE: E10180 SIDER: C0031046 pharyngeal edema AE WEB: http://www.ncbi.nlm.nih.gov/mesh/68004487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Mesh.Mesh_ResultsPanel.Mesh_RVDocSum pharyngeal oedema AE SS, YH pharyngeal edema AE is an edema AE that results in an bbnormal fluid accumulation in TISSUES or body cavities in pharynx (throat swelling). pharyngitis AE 10034835 SS, YH WEB: http://en.wikipedia.org/wiki/Pharyngitis pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx SIDER: C0031350 NCIt: C26851 CTCAE: E11525 HPO: HP_0100776 pharyngolaryngeal pain AE 10034844 a pain AE that shows a pain in sinus and throat NCIt: C78556 SS, YH, MW WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/ HPO: HP_0010833 CTCAE: E13482 SIDER: C0858635 macular rash AE HPO: HP_0000988 rash macular AE is a rash AE that results in a skin eruption in which the lesions are flat and less than 1 cm in diameter SS, YH rash macular AE SIDER: C0221201 WEB: http://medical-dictionary.thefreedictionary.com/macular+rash papular rash AE 10037876 HPO: HP_0007432 WEB: http://www.rightdiagnosis.com/sym/papular_rash.htm SS, YH rash papular AE WEB: http://www.healthline.com/symptom/papule WEB: http://en.wikipedia.org/wiki/Rash a rash AE that shows clustered papules, i.e., small, round, raised bumps that have clear borders. SIDER: C0221202 respiratory distress AE 10038687 WEB: http://en.wikipedia.org/wiki/Acute_respiratory_distress_syndrome HPO: HP_0002747 SS, YH respiratory distress AE is a respiratory system AE that results in a severe lung disease caused by a variety of direct and indirect issues. It is characterized by inflammation of the lung parenchyma leading to impaired gas exchange with concomitant systemic release of inflammatory mediators causing inflammation, hypoxemia and frequently resulting in multiple organ failure. SIDER: C0476273 respiratory tract congestion AE SS, YH respiratory tract congestion AE is a respiratory system AE that results in congestion in respiratory tract retching AE 10038776 retching AE is a digestive system AE that results in a process in the human body where gastric (and sometimes duodenal) contents are forced into the esophagus, but do not enter the pharynx SS, YH WEB: http://en.wikipedia.org/wiki/Retching rhinitis AE 10028116 runny nose WEB: http://en.wikipedia.org/wiki/Rhinitis SIDER: C0035455 WEB: http://medical-dictionary.thefreedictionary.com/rhinitis HPO: HP_0002257 SS, YH rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose rhinorrhea AE SS, YH rhinorrhoea AE WEB: http://en.wikipedia.org/wiki/Rhinorrhoea rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid shoulder pain AE shoulder pain is a pain iin or around the shoulder joint WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003171.htm a pain AE that occurs in shoulder SS, YH sinus congestion AE HPO: HP_0002257 SS, YH WEB: http://en.wikipedia.org/wiki/Sinus_%28anatomy%29, http://en.wikipedia.org/wiki/Nasal_congestion SIDER: C0152029 sinus congestion AE is a nasal congestion AE that results in blockage of the air cavities in the cranial bones or nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels sneezing AE 10041232 sneezing AE is a respiratory system adverse event that results in sternutation, a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa CTCAE:E13572 WEB: http://en.wikipedia.org/wiki/Sneezing sternutation SS, YH, MW NCIt:C50746 tachycardia AE 10043071 SIDER: C0039231 WEB: http://en.wikipedia.org/wiki/Tachycardia an increased heart rate AE where the heart rate exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual) SS, YH HPO: HP_0001649 tendonitis AE a tendon disorder AE that has an outcome of tendonitis SIDER: C0039503 SS, YH tendonitis is a tendon disorder that results in an inflammation of a tendon HPO: HP_0100261 WEB: http://en.wikipedia.org/wiki/Tendinitis tendinitis AE throat tightness AE 10043528 a sensory capability AE that has an outcome of a sensation of tightness in the throat upper respiratory tract infection AE 10046300 SS, YH CTCAE: E11604 NCIt: C35650 an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx SIDER: C0041912 URI, URTI HPO: HP_0002788 WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection varicella AE a viral infection AE that results in an acute contagious diseased caused by herpes varicella zoster virus; causes a rash of vesicles on the face and body. varicella zoster virus infection AE chicken pox AE WEB: http://wordnetweb.princeton.edu/perl/webwn?s=varicella SS, YH SIDER: C0008049 HPO: HP_0005428 paresthesia oral AE 10057372 paraesthesia oral AE http://www.answers.com/topic/oral-paresthesia paraesthesia oral is a paresthesia that results in a numbness or tingling that occurs in the mucosa or tissues of the oral cavity. a paresthesia AE that occurs in oral area. SS, YH HPO: HP_0003401 SIDER: C0521591 fever AE 10005911 10016558 10037660 Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. YH, SS, MW WEB: http://en.wikipedia.org/wiki/Pyrexia febrile response an abnormal body temperature AE which has an outcome of fever CTCAE: E11102 body temperature increased AE pyrexia AE NCIt: C3038 Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °F). rash AE 10037844 URL: http://www.webmd.com/skin-problems-and-treatments/guide/common-rashes Wick JY. Drug-induced rash: nuisance or threat? Consult Pharm. 2013 Mar;28(3):160-6. PMID: 23462025. a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. YH SIDER: C0015230 URL: http://en.wikipedia.org/wiki/Rash HPO: HP_0000988 Drug-induced rash is the most commonly reported drug reaction. infection AE 10021789 YH, JX change of name from 'infection adverse event' to 'infectious adverse event' on 09/23/13 for a better clinical relevance, move 'infection adverse event' as an alternative term - SS an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite. infection infectious adverse event WEB: http://medical-dictionary.thefreedictionary.com/infection syndrome AE An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. YH agitation AE 10001497 HPO: HP_0000711 a psychiatric disorder AE that has an outcome of emotional state of excitement or restlessness CTCAE:E12874 YH, MW SIDER: C0085631 NCIt:C79530 injection-site AE 10022095 injection site AE YH, JX, SS injection-site AE is an AE that occurs in an injection site (e.g., during vaccination). CTCAE: E11138 NCIt: C3508 injection-site adverse event injection-site reaction local reaction AE injection-site hypersensitivity AE a hypersensitivity AE which has an outcome of injection-site hypersensitivity YH injection-site edema AE 10053425 an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found. injection-site oedema AE YH, RR injection-site swelling AE WEB: http://www.uptodate.com/contents/edema-swelling-beyond-the-basics injection-site pain AE 10022086 a pain AE that occurs in an injection site of a medical intervention YH injection-site inflammation AE YH an inflammation AE which has an outcome of injection-site inflammation injection-site hemorrhage AE 10022067 YH a hemorrhage AE that has an outcome of injection-site hemorrhage injection-site mass AE YH, SS injection site nodule AE injection-site mass is a mass at physical injection site a tumor or mass AE that occurs in an injection-site pruritus AE 10037087 NCIt:C3344 SIDER: C0033774 WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity CTCAE:E13686 itching YH, SS, MW pruritus generalised AE itch Pruritus is an itch (Latin: pruritus), i.e., an unpleasant sensation that evokes the desire or reflex to scratch. HPO: HP_0000989 a skin adverse event that has an outcome of pruritus pain AE 10033371 CTCAE: E11167 SIDER: C0030193 HPO: HP_0010833 NCIt: C3303 YH, MW a sensory capability AE that has an outcome of pain in a patient myalgia AE 10028411 HPO: HP_0003326 muscle pain AE SIDER: C0231528 CTCAE:E12485 NCIt:C27009 YH, MW a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders. urticaria AE 10046735 SIDER: C0042109 YH, MW Urticaria AE is a rash AE notable for dark red, raised, itchy bumps. hives CTCAE:E13746 HPO: HP_0001025 NCIt:C3432 headache AE 10019211 CTCAE: E12678 SIDER: C0018681 a pain AE that has an outcome of headache HPO: HP_0002315 YH, MW NCIt: C34661 respiratory system AE I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He YH an AE that occurs in respiratory system. leukocyte cell number increased AE 10024378 10047943 CTCAE: E10048 WEB: http://en.wikipedia.org/wiki/Leukocytosis According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). white blood cell count increased AE NCIt: C35524 leukocytosis AE increased leukocyte cell number AE MP: MP_0000218 SS, YH, EB a leukocyte cell number abnormal AE that has an outcome of greater than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue leukocyte cell number decreased AE 10047942 CTCAE: E12232 a leukocyte cell number abnormal AE that has an outcome of reduction in the number of leukocytes, or of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue white blood cell count decreased AE decreased leukocyte cell number AE MP: MP_0000221 According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). NCIt: C26816 abnormal blood pressure AE MP: MP_0000230 a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries asthenia AE 10003549 HPO: HP_0001324 YH SIDER: C0004093 a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength. muscle ache AE a muscle pain AE that has an outcome of muscle ache. YH maculo-papular rash AE 10037868 YH, MW maculopapular rash AE WEB: http://en.wikipedia.org/wiki/Maculopapular_rash The term "maculopapular" is a compound: macules are small, flat discolored spots on the surface of the skin; and papules are small, raised bumps. CTCAE:E13700 rash maculopapular AE rash maculo-papular AE A rash AE that shows a flat, red area on the skin overed with small confluent bumps. NCIt:C75579 arthralgia AE 10003239 An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. CTCAE:E12374 NCIt:C50464 SIDER: C0003862 YH, MW HPO: HP_0002829 vesiculobullous rash AE YH HPO: HP_0000988 SIDER: C0151883 vesiculobullous rash AE is a rash AE characterized by serous-fluid-filled vesicles (blisters) screaming syndrome AE a syndrome AE which has an outcome of screaming syndrome YH dizziness AE 10013573 HPO: HP_0002321 NCIt:C37943 SIDER: C0012833 YH, SS, MW a sensory capability AE that has an outcome of dizziness Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. CTCAE:E12631 edema limbs AE 10030124 10050068 CTCAE: E11086 NCIt: C78262 YH, SS oedema peripheral AE peripheral edema AE edema peripheral AE peripheral edema AE is an edema AE that results in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids WEB: http://en.wikipedia.org/wiki/Peripheral_edema malaise AE 10025482 YH HPO: HP_0002321 CTCAE: E11152 NCIt: C3832 Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. SIDER: C0231218 a sensory capability AE that has an outcome of malaise somnolence AE 10041349 CTCAE:E12814 HPO: HP_0001262 drowsiness a behavior and neurological AE that has an outcome of somnolence Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). SIDER: C2830004 YH, SS, MW NCIt:C26754 paresthesia AE 10033775 10033987 a sensory neuropathy AE that shows a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect. CTCAE: E12758 Paresthesia is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic. YH, MW paraesthesia AE WEB: http://en.wikipedia.org/wiki/Paraesthesia NCIt: C28177 crying abnormal AE 10011469 YH a behavior and neurological AE that has an outcome of abnormal crying in a patient chills AE 10008531 feeling cold AE YH CTCAE: E11074 SIDER: C0085593 Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. HPO: HP_0001945 a sensory capability AE that has an outcome of chills NCIt: C35143 stupor AE 10042264 YH Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization. a behavior and neurological AE that has an outcome of stupor HPO: HP_0004372 SIDER: C0085628 anorexia AE 10002646 10002649 10061428 decreased appetite AE YH, MW NCIt: C2875 HPO: HP_0002039 a gustatory system AE which demonstrates a decreased sensation of appetite. WEB: http://www.mayoclinic.org/diseases-conditions/anorexia/basics/definition/con-20033002 anorexia nervosa AE CTCAE: E12252 SIDER: C0003123 厌食症 face edema AE 10014222 10016029 10042682 NCIt: C78289 swelling face face oedema AE WEB:http://www.nlm.nih.gov/medlineplus/ency/article/003105.htm CTCAE: E11082 oedema face AE emema face AE face edema AE is an edema AE that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms YH, SS, MW cough AE 10011224 WEB: http://medical-dictionary.thefreedictionary.com/cough YH, SS, MW coughing AE cough WEB: http://www.nlm.nih.gov/medlineplus/cough.html an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear CTCAE:E13364 NCIt:C37935 flu syndrome AE YH NCIt: C78302 CTCAE: E11108 flu-like symptom AE a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention. syncope AE 10024855 10042772 SIDER: C0039070 a sensory capability AE that has an outcome of loss of consciousness, fainting WEB: http://en.wikipedia.org/wiki/Unconsciousness fainting Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. CTCAE: E12832 NCIt: C35053 YH, SS, MW HPO: HP_0001279 WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29 sweating AE YH a skin adverse event that has an outcome of sweating SIDER: C0038990 According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). HPO: HP_0000975 abdominal pain AE 10000081 WEB: http://en.wikipedia.org/wiki/Abdominal_pain HPO: HP_0002027 SIDER: C0000737 YH, SS According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). a pain AE that is observed in abdominal cavity hypertension AE 10005750 10020772 CTCAE: E13785 NCIt: C3117 HPO: HP_0000822 blood pressure increased SIDER: C0020538 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21722707 YH, SS, MW an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states MP: MP_0000231 aortic valve stenosis AE 10002918 SIDER: C0003507 SS WEB: http://medical-dictionary.thefreedictionary.com/aortic+valve+stenosis a cardiac valve disease AE that is characterized by a condition of the heart in which the aortic valve, located between the aorta and left ventricle of the heart, is norrower than normal size HPO: HP_0005173 myasthenia AE a muscular weakness AE that has an outcome of myasthenia. Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. YH, SS SIDER: C0947912 myasthenia syndrome AE myasthenic syndrome AE HPO: HP_0001324 myasthenia gravis chest pain AE 10008479 SIDER: C0008031 YH HPO: HP_0001681 According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). a pain AE that occurs at the chest sensory axonal AE a sensory neuropathy AE which has an outcome of sensory axonal characterized by damage to axonas of the peripheral nervous system (PNS) AG, YH central serous retinopathy AE 10063118 WEB: http://en.wikipedia.org/wiki/Central_serous_retinopathy SJ, YH an abnormal vision AE characterised by leakage of fluid under the retina causing visual impairment, usually in one eye. central serous chorioretinopathy twitching AE a movement disorder AE that has an outcome of twitching, an involuntary sudden movement of part of the body. According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). YH febrile seizure AE a seizure AE that has an outcome of a seizure disorder associated with an elevated temperature http://emedicine.medscape.com/article/1176205-overview YH, BY asthma AE 10003553 哮喘 Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation. HPO: HP_0002099 YH a respiratory system AE which has an outcome of asthma SIDER: C0004096 neck pain AE 10028836 SIDER: C0007859 CTCAE: E12493 NCIt: C50663 YH, MW According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). HPO: HP_0003418 a pain AE that has an outcome of neck pain arthritis infective AE 10060968 HPO: HP_0003095 DJ, SS, YH WEB: http://www.rightdiagnosis.com/i/infectious_arthritis/intro.htm SIDER: C0003869 an arthritis AE that has an outcome of inflammation of a joint, resulting from infectious agents, such as bacteria and viruses back pain AE 10003988 NCIt:C41830 According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). CTCAE:E12388 a pain AE that has an outcome of back pain SIDER: C0004604 YH, MW HPO: HP_0003418 alopecia AE 10001760 SIDER: C0002170 VAE, MW NCIt:C50575 alopecia means the absence of hair or loss of hair. It is not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition. HPO: HP_0001596 CTCAE:E13611 MP: MP_0000414 a hair AE that has an outcome of alopecia and occurs after a medical intervention. gastrointestinal hemorrhage AE 10017955 MP: MP_0000465 a hemorrhage AE that has an outcome of gastrointestinal hemorrhage gastrointestinal haemorrhage AE WEB: http://medical-dictionary.thefreedictionary.com/gastrointestinal+hemorrhage bleeding in the stomach and/or the intestines eyes gaze upward AE YH a movement disorder AE that has an outcome of eyes gaze upward According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). neuropathy AE WEB: http://www.neuropathy.org/ SIDER: C0442874 a nervous system AE that shows a damage to or disease affecting the nerves. 神经病变 WEB: http://www.medicalnewstoday.com/articles/147963.php YH, RR WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm Neuropathy is often classified according to the types or location of nerves that are affected. Neuropathy can also be classified according to the disease causing it. (For example, neuropathy from the effects of diabetes is called diabetic neuropathy. Ref: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy. HPO: HP_0007141 skin nodule AE YH According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). a skin adverse event that has an outcome of skin nodule HPO: HP_0200036 SIDER: C0037287 arthrosis AE Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage. YH a movement disorder AE that has an outcome of arthrosis. hypokinesia AE 10021021 HPO: HP_0002375 YH SIDER: C0086439 a muscle adverse event which has an outcome of hypokinesia, refering to slow or diminished movement of body musculature. muscle twitch AE 10028346 JX, YH WEB: http://en.wikipedia.org/wiki/Fasciculation fasciculation AE muscle contraction AE myokymia AE Muscle twitch AE is a twitching AE that is a small, local, involuntary muscle contraction and relaxation which may be visible under the skin. skin discoloration AE 10040829 skin discoloration AE is a skin adverse event that results in change in color of skin or mucus membranes skin discolouration AE YH, SS According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). shingles AE 10019974 a varicella zoster virus infection AE that occurs in adults and rarely in children. zoster AE Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles (an illness with very different symptoms) often many years after the initial infection. YH SIDER: C0019360 herpes zoster AE HPO: HP_0005353 WEB: http://www.mayoclinic.org/diseases-conditions/shingles/basics/causes/con-20019574 laryngismus AE sudden laryngeal spasm with crowing inhalation and cyanosis a movement disorder AE that has an outcome of laryngismus laryngospasm Laryngismus is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH speech disorder AE 10041466 YH a behavior and neurological AE that has an outcome of disorder in speech SIDER: C0037822 HPO: HP_0006977 hemorrhage AE 10055798 WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage haemorrhage AE bleeding AE MP: MP_0001914 a cardiovascular disorder AE that has an outcome of hemorrhage loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels neck rigidity AE a bone disorder AE which has an outcome of neck rigidity YH Guillain-Barre syndrome AE 10018767 SIDER: C0018378 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299621 a nervous system AE that has the symptom of GBS. Guillain-Barre syndrome (GBS) is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barre occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm. GBS AE YH, SS HPO: HP_0007131 nausea and vomiting AE YH This term will most likely removed since it is just a combination of nausea and vomiting. an abnormal digestion AE which has an outcome of nausea and vomiting According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). sudden infant death AE a sudden death AE that occurs to an infant. According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). YH fever with chills AE 10016559 YH chills and fever AE a fever AE that has an outcome of fever with chills, which is successive stages of chills and fever. This is a symptom of malaria. personality disorder AE 10034721 SIDER: C0031212 a psychiatric disorder AE that is characterized by enduring maladaptive patterns of behavior, cognition, and inner experience, exhibited across many contexts and deviating markedly from those accepted by the individual's culture. YH, MW HPO: HP_0000751 WEB: https://en.wikipedia.org/wiki/Personality_disorder lung AE 10025082 YH SIDER: C0024115 lung disorder AE a respiratory system AE which has an outcome of lung disorder HPO: HP_0006552 muscle AE a musculoskeletal system AE that occurs in muscle. YH hepatobiliary or pancreatic AE YH, JX an adverse event that occurs in liver, biliary, and pancreatic areas. URL: http://www.ijhpd.com/ WEB: http://www.uchospitals.edu/online-library/content=P00670 liver, biliary, and pancreatic disorder AE enlarged liver AE According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly' was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000599 a liver/biliary system AE which has an outcome of an enlarged liver, or larger than average size of the liver meningitis AE 10027199 WEB: http://www.cdc.gov/meningitis/index.html SIDER: C0025289 脑膜炎 a brain inflammation AE which results in an inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases. YH, JX HPO: HP_0001287 CTCAE: E11458 NCIt: C26828 digestive system AE YH an AE that occurs in digestive system. facial paralysis AE SIDER: C0015469 HPO: HP_0007209 a paralysis AE that has an outcome of paralysis in face According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). YH confusion AE 10010300 10010305 YH, KM WEB: http://medical-dictionary.thefreedictionary.com/mental+confusion NCIt: C37928 a psychiatric disorder AE that has an outcome of confusion, which is a mild form of delirium. mental confusion AE CTCAE: E12889 confused state AE joint disorder AE a musculoskeletal system AE which has an outcome of joint disorder YH eye AE 10015916 YH an AE that occurs in eye. eye disorder AE HPO: HP_0000496 SIDER: C0015397 autism AE a behavior and neurological AE that has an outcome of autism Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. YH sedimentation rate increased AE YH red blood cell sedimentation rate increased AE Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short. ESR sedrate red blood cell sedimentation rate increased AE is an AE: sedimentation rate increased that has an increase in rate at which red blood cells precipitate in a period of 1 hour. This term should be inferred to lab test abnormal. erythrocyte sedimentation rate a hematopoietic system AE which has an outcome of sedimentation rate increased According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). arthritis reactive AE 10003267 WEB: http://www.ncbi.nlm.nih.gov/pubmed/16822921 DJ, SS, YH an arthritis AE that has an outcome of arthritis due to an infection in another part of the body amblyopia AE 10001906 an abnormal vision AE which has an outcome of amblyopia SIDER: C0002418 YH HPO: HP_0000646 mental retardation AE a psychiatric disorder AE that has an outcome of mental retardation HPO: HP_0001249 SIDER: C0025362 YH erythema multiforme AE 10015218 a rash AE which shows red, target-shaped or "bulls-eye" patches or sores on the skin. WEB: https://en.wikipedia.org/wiki/Erythema_multiforme The erythema multiforme rash usually begins on the arms, hands, legs, and feet, but you might also find it on the face, neck, and body. It also can affect the lips and inside the mouth. It usuallys follows an infection or drug exposure. HPO: HP_0010783 WEB: http://kidshealth.org/parent/infections/skin/erythema_multiforme.html SIDER: C0014742 YH, MW CTCAE:E13627 NCIt:C3024 SGOT increased AE SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). a lab test abnormal AE that has an outcome of SGOT increased SGPT increased AE a lab test abnormal AE that has an outcome of SGPT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT). thinking abnormality AE 10043431 a behavioral and neurological AE that has an outcome of thinking abnormality According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH, JX dyspepsia AE 10013946 CTCAE: E10617 NCIt: C26756 HPO: HP_0002577 According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). an abnormal digestion AE which has an outcome of dyspepsia SIDER: C0013395 Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating. YH anaphylactoid reaction AE 10002198 10002216 HPO: HP_0100845 YH According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). WEB: http://www.ncbi.nlm.nih.gov/pubmed/22293078 SIDER: C0340865 an allergy AE which has an outcome of anaphylactoid reaction AE is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. gastrointestinal disorder AE SIDER: C0017178 According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). a digestive system AE which has an outcome of a gastrointestinal disorder YH HPO: HP_0011024 ascites AE 10003445 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23296107 DJ, SS, YH an edema AE that has an outcome of accumulation of fluid in the peritoneal cavity CTCAE: E10502 HPO: HP_0001541 NCIt: C2885 SIDER: C0003962 serum sickness AE 10040400 a hypersensitivity AE which has an outcome of serum sickness Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, MW NCIt: C79718 CTCAE: E11276 injection-site abscess AE an abscess AE which has an outcome of injection-site abscess YH abnormal electroencephalogram result AE 10000130 According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, EB WEB: http://www.mayoclinic.com/health/eeg/MY00296 a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of a procedure that uses small, flat metal discs (electrodes) attached to your scalp to detect electrical activity in your brain vertigo AE 10047340 According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). NCIt: C38057 Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking. HPO: HP_0002321 SIDER: C0042571 CTCAE: E10291 YH a dizziness AE that has an outcome of vertigo cardiac arrest 10007515 10007617 10028596 WEB: http://medical-dictionary.thefreedictionary.com/cardiac+arrest a cardiac disorder AE that has an outcome of heartarrest, the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole. cardiopulmonary arrest YH circulatory arrest NCIT: C50479 WEB: http://en.wikipedia.org/wiki/Myocardial_infarction CTCAE: E10101 heart arrest AE bronchitis AE SIDER: C0006277 YH a respiratory system inflammation AE which has an outcome of bronchitis HPO: HP_0002837 Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes. grand malconvulsion AE YH a seizure AE that has an outcome of grand malconvulsion A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). liver function test abnormal AE 10019670 10024690 WEB: http://medical-dictionary.thefreedictionary.com/hepatic+function MP: MP_0000609 According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). a liver related investigation result abnormal AE which shows an abnormal test result in a liver function test, indicating aberrant function of liver. ear AE an AE that occurs in ear. SIDER: C0013447 ear disorder AE YH HPO: HP_0000598 viral infection AE viral infection HPO: HP_0005364 SIDER: C0042769 an infection AE that results in detrimental colonization of a host organism by virus YH, SS WEB: http://en.wikipedia.org/wiki/Viral_infection lacrimation disorder AE Lacrimation is the production, secretion, and shedding of tears. a movement disorder AE that has an outcome of lacrimation disorder YH According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). jaundice AE 10023126 WEB: http://en.wikipedia.org/wiki/Jaundice According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). icterus AE MP: MP_0000611 SIDER: C0022346 a liver/biliary system AE which has an outcome of jaundice, which is the clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes HPO: HP_0000952 SS, YH abscess AE 10000269 abscessus an immune system disorder AE which shows an enclosed collection of liquefied tissue, known as pus, somewhere in the body. Abscess is the result of the body's defensive reaction to foreign material. WEB: http://medical-dictionary.thefreedictionary.com/abscess HPO: HP_0002722 An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body. SIDER: C0000833 YH eye pain AE 10015958 SIDER: C0151827 According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). a pain AE that has an outcome of eye pain CTCAE: E10376 NCIt: C78287 HPO: HP_0200025 YH palpitation AE 10033557 WEB: http://en.wikipedia.org/wiki/Palpitations a sensory capability AE that has an outcome of palpitation A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency. YH tongue edema AE 10042727 tongue swelling AE an edema AE which has an outcome of tongue edema tongue oedema AE YH, RR WEB: http://www.medterms.com/script/main/art.asp?articlekey=97582 ear pain AE 10014020 NCIt: C37944 HPO: HP_0010833 YH CTCAE: E10262 SIDER: C0013456 a pain AE that has an outcome of ear pain According to the Vaccine Adverse Event Reporting System (VAERS), 'ear pain' was mentioned in 302 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). angioedema AE 10002473 an edema AE which has an outcome of angioedema Angioedema is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues often around the eyes and lips. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis. angioneurotic edema WEB: http://www.mayoclinic.org/diseases-conditions/hives-and-angioedema/basics/definition/con-20014815 YH, SJ rheumatoid arthritis AE HPO: HP_0005681 An arthritis AE that has the outcome of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body. SIDER: C0003873 YH immune system AE According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). HPO: HP_0002715 YH SIDER: C0021053 immune system disorder AE an AE that occurs in immune system. antinuclear antibody present AE anti-nuclear factor present The presence of anti-nuclear antibodies (ANAs) that are antibodies directed against contents of the cell nucleus. ANAs are present in higher than normal numbers in autoimmune disease. The ANA test measures the pattern and amount of autoantibody which can attack the body's tissues as if they were foreign material. Autoantibodies are present in low titers in the general population, but in about 5% of the population, their concentration is increased, and about half of this 5% have an autoimmune disease. According to the Vaccine Adverse Event Reporting System (VAERS), 'antinuclear antibody present'; is an adverse event that was mentioned in 288 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH an immune system disorder AE which has an outcome of antinuclear antibody present myelitis AE 10028524 a nervous system AE which involves inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs. CTCAE: E12732 YH, MW NCIt: C26832 migraine AE migraine headache YH HPO: HP_0002076 According to the Vaccine Adverse Event Reporting System (VAERS), 'migraine'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). a headache AE that has an outcome of migraine SIDER: C0149931 A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit. thrombocytopenic purpura AE 10043561 According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenic purpura'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). HPO: HP_0004829 Thrombocytopenic purpura AE are purpura AE associated with a reduction in circulating blood platelets which can result from a variety of causes. YH SIDER: C0857305 multiple sclerosis AE 10028245 disseminated sclerosis encephalomyelitis disseminata MS YH multiple sclerosis AE is an immune system disorder AE, or an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination. amnesia AE 10001949 a behavior and neurological AE that has an outcome of amnesia in a patient HPO: HP_0002354 SIDER: C0002622 CTCAE:E12585 Amnesia is a short term memory condition in which memory is disturbed. In simple terms it is the loss of memory. YH, MW NCIt:C2867 incoordination AE YH According to the Vaccine Adverse Event Reporting System (VAERS), 'incoordination' was mentioned in 261 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). a movement disorder AE that has an outcome of incoordination a lack of normal adjustment of muscular action so that the intended movement of the limb or other part is not made smoothly and harmoniously, and does not accurately achieve its objective. If the abnormality is hypermetric, the condition is referred to as ataxia. If it is inclined to weakness, e.g. knuckling at the turn, stumbling, failure to flex limbs properly, or to misdirection as in a proprioceptive deficit, it is called incoordination. voice alteration AE 10047681 YH, MW a speech disorder that has an outcome of voice alteration CTCAE: E13601 NCIt: C61043 abortion AE 10000210 a pregnancy AE that is the termination of a pregnancyby the removal or expulsion from the uterus of a fetus or embryo, resulting in or caused by its death. WEB: http://en.wikipedia.org/wiki/Abortion According to the Vaccine Adverse Event Reporting System (VAERS), 'abortion'; is an adverse event that was mentioned in 257 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH, SS psychological shock AE 10001084 mental shock AE acute stress reaction AE Mental shock (or shock) is a psychological condition arising in response to a terrifying event. It should not be confused with the unrelated circulatory condition of shock. acute stress disorder AE a psychiatric disorder AE that has an outcome of shock YH There are two types of shocks. Another is circulatory shock which is physiological with MedDRA ID of 10040560. purpura AE 10037549 HPO: HP_0000979 Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia. Reference: http://en.wikipedia.org/wiki/Purpura. NCIt:C78787 YH, MW CTCAE:E13690 紫癜 SIDER: C0034150 According to the Vaccine Adverse Event Reporting System (VAERS), 'purpura'; is an adverse event that was mentioned in 251 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). a skin discoloration AE which has an outcome of purpura bacterial infection AE 10060945 bacterial infection AE WEB: http://en.wikipedia.org/wiki/Bacterial_infection an infection AE that results in detrimental colonization of a host organism by bacteria HPO: HP_0002718 YH, SS SIDER: C0004623 skin striae AE SIDER: C0152459 YH stretch marks striae distensae HPO: HP_0001065 a skin adverse event that has an outcome of skin striae that displays irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions. According to the Vaccine Adverse Event Reporting System (VAERS), 'skin striae'; is an adverse event that was mentioned in 247 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). acute brain syndrome AE a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention. YH coma AE 10010071 Coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions. HPO: HP_0001259 a sensory capability AE that has an outcome of coma YH SIDER: C0009421 hyperkinesia AE 10020651 SIDER: C0424295 HPO: HP_0002487 a muscle adverse event which has an outcome of hyperkinesia, an abnormal increase in muscular activity. YH cardiovascular AE 10007649 HPO: HP_0001626 SIDER: C0007222 YH an AE that occurs in cardiovascular system. cardiovascular disorder AE encephalopathy AE 10014625 SIDER: C0085584 CTCAE:E12652 NCIt:C26920 YH, MW a nervous system AE which has an outcome of encephalopathy, which is disorder or disease of the brain. HPO: HP_0007239 urine abnormality AE SIDER: C0235639 a urinary system AE that has an outcome of urine abnormality AE HPO: HP_0011036 YH gastroenteritis AE 10017888 HPO: HP_0004386 YH SIDER: C0017160 According to the Vaccine Adverse Event Reporting System (VAERS), 'gastroenteritis' was mentioned in 218 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). WEB: http://medical-dictionary.thefreedictionary.com/gastroenteritis a gastrointestinal disorder AE which has an outcome of gastroenteritis, an inflammation occuring in the gastrointestinal tract that involves both the stomach and the small intestine, often results in diarrhea, vomiting and abdominal pain and cramping peripheral vascular disorder AE SIDER: C0085096 a cardiovascular disorder AE that has an outcome of peripheral vascular disorder HPO: HP_0005299 YH urinary tract infection AE 10046571 SIDER: C0042029 HPO: HP_0000094 YH CTCAE: E11614 NCIt: C50791 a urinary system AE that has an outcome of urnary tract infection AE increased salivation AE MP: MP_0000622 According to the Vaccine Adverse Event Reporting System (VAERS), 'increased salivation' is an adverse event that was mentioned in 336 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). an abnormal salivary gland physiology AE which has an outcome of increased salivation, meaning greater than normal amounts of flowing saliva depression AE 10012378 CTCAE:E12909 a psychiatric disorder AE that has an outcome of depression. Depression causes a persistent feeling of sadness and loss of interest. NCIt:C2982 SIDER: C0011570 WEB: http://www.mayoclinic.org/diseases-conditions/depression/basics/definition/con-20032977 YH, MW HPO: HP_0000716 diabetes mellitus AE 10012601 HPO: HP_0000819 SIDER: C0011849 YH diabetes AE a glucose homeostasis AE which has an outcome of diabetes mellitus Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia). laryngitis AE 10023874 CTCAE: E11435 YH SIDER: C0023067 Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice because of irritation to the vocal folds (vocal cords). NCIt: C26811 HPO: HP_0001600 a respiratory system inflammation AE which has an outcome of laryngitis According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngitis'; is an adverse event that was mentioned in 190 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). generalized spasm AE YH a muscle spasm AE which has an outcome of generalized spasm, which is an involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH). obsolete: reflexes decreased AE a movement disorder AE that has an outcome of reflexes decreased, an abnormal decrease in an involuntary response to a peripheral stimulus According to the Vaccine Adverse Event Reporting System (VAERS), 'reflexes decreased'; is an adverse event that was mentioned in 178 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). Obsoleted because of duplication. It's an alternative term of hyporeflexia AE now. YH hyporeflexia AE dry mouth AE 10013781 xerostomia NCIt: C26917 HPO: HP_0000217 a digestive system AE which has an outcome of dry mouth, which is dryness of the mouth resulting from reduced salivary secretion YH According to the Vaccine Adverse Event Reporting System (VAERS), 'dry mouth'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). CTCAE: E10578 SIDER: C0043352 optic neuritis AE 10030942 HPO: HP_0100653 a neuritis AE which has an outcome of optic neuritis SIDER: C0029134 YH thrombocythemia AE YH Thrombocythemia (primary thrombocythemia) is a disorder in which excess platelets are produced, leading to abnormal blood clotting or bleeding. a cardiovascular disorder AE that has an outcome of thrombocythemia epistaxis AE 10015090 YH, MW NCIt:C26766 nosebleed Epistaxis is the relatively common occurrence of hemorrhage from the nose, usually noticed when the blood drains out through the nostrils. SIDER: C0014591 HPO: HP_0000421 a hemorrhage AE that has an outcome of epistaxis CTCAE:E13374 lupus AE 狼疮样综合征 lupus syndrome AE YH, JX WEB: http://www.medicalnewstoday.com/info/lupus/ a syndrome AE that displays a lupus syndrome. Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. This results in symptoms such as inflammation, swelling, and damage to joints, skin, kidneys, blood, the heart, and lungs. photophobia AE 10034960 Photophobia is a symptom of excessive sensitivity to light and the aversion to sunlight or well-lit places. In medical terms it is not fear, but an experience of discomfort or pain to the eyes due to light exposure. CTCAE: E10416 NCIt: C28210 an eye disorder AE which has an outcome of photophobia HPO: HP_0000613 SIDER: C0085636 YH abnormal salivary gland physiology AE MP: MP_0005310 a digestive system AE which has an outcome of abnormal salivary gland physiology, which is any functional anomaly of any of the glands in the mouth that secrete saliva hallucination AE 10019063 10019077 NCIt: C37961 HPO: HP_0000738 A hallucination, in the broadest sense, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space. YH, MW hallucinations AE a psychiatric disorder AE that has an outcome of hallucination SIDER: C0018524 CTCAE: E12919 tongue disorder HPO: HP_0000157 SIDER: C0040409 a digestive system AE which has an outcome of tongue disorder YH According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue disorder'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). neuralgia AE 10029223 CTCAE:E12744 a pain AE that has an outcome of neuralgia Neuralgia or neuropathic pain can be defined most simply as non-nociceptive pain. Neuralgia is pain produced by a change in neurological structure or function. Unlike nociceptive pain, Neuralgia exists with no continuous nociceptive input. Neuralgia falls into two categories: central Neuralgia and peripheral Neuralgia. According to the Vaccine Adverse Event Reporting System (VAERS), 'neuralgia'; is an adverse event that was mentioned in 155 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). NCIt:C79695 HPO: HP_0003489 SIDER: C0027796 YH, MW lung edema AE an edema AE which has an outcome of lung edema YH circumoral paresthesia AE a paresthesia AE that occurs around the mouth. YH HPO: HP_0003401 SIDER: C0151838 thirst AE 10043458 SIDER: C0039971 an abnormal fluid regulation AE which has an outcome of thirst HPO: HP_0001959 Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance. YH bone AE 10005956 HPO: HP_0000924 SIDER: C0005940 YH a musculoskeletal system AE that occurs in the bone bone disorder fetal disorder AE a perinatal AE that displays fetal disorder. YH emotional liability AE a sensory capability AE that has an outcome of emotional liability YH muscle spasm AE 10028334 MP: MP_0000743 SS, YH WEB: http://en.wikipedia.org/wiki/Spasm a muscle adverse event which has an outcome of muscle spasm, which is an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions tendon disorder AE a connective tissue disorder AE that occurs at the location of tendon YH According to the Vaccine Adverse Event Reporting System (VAERS), 'tendon disorder'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension. Tendon disorder is a medical condition that results in a tendon not functioning normally. hostility AE 10020400 YH a behavior and neurological AE that has an outcome of hostility visual field defect AE 10047555 10047571 SS, YH visual impairment AE WEB: http://en.wikipedia.org/wiki/Visual_impairment an eye disorder AE which has an outcome of visual field defect myopathy AE 10028641 SIDER: C0026848 HPO: HP_0003198 MP: MP_0000751 a muscle adverse event which has an outcome of myopathy AE, an abnormal condition or disease of the skeletal muscle apathy AE 10002942 HPO: HP_0000741 SIDER: C0085632 YH a behavior and neurological AE that has an outcome of apathy state impassivity perfunctoriness Apathy is a state of indifference, or the suppression of emotions such as concern, excitement, motivation and passion. An apathetic individual has an absence of interest or concern to emotional, social, or physical life. They may also exhibit an insensibility or sluggishness. hemiplegia AE 10019468 YH SIDER: C0018991 HPO: HP_0002301 a paralysis AE that has an outcome of hemiplegia Hemiplegia is total paralysis of the arm, leg, and trunk on the same side of the body. Hemiplegia is more severe than hemiparesis, wherein one half of the body is weakened but not paralysed. According to the Vaccine Adverse Event Reporting System (VAERS), 'hemiplegia'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). pustular rash AE 10037888 According to the Vaccine Adverse Event Reporting System (VAERS), 'pustular rash'; is an adverse event that was mentioned in 128 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). CTCAE: E11545 a rash AE that is characterized by a circumscribed and elevated skin lesion filled with pus. rash pustular AE NCIt: C80119 YH blood creatine phosphokinase level increased AE 10005470 YH, EB elevated serum creatine phosphate kinase AE a blood creatine phosphokinase level abnormal AE that is characterized by an increased level of creatine phosphokinase (CPK) or phosphocreatine kinase, an enzyme expressed by various tissue types that catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP) intracranial hypertension AE 10049977 a hypertension AE that has an outcome of elevated pressure in the skull. WEB: http://www.ihrfoundation.org/intracranial/hypertension/info/C16 YH, SS sensorimotor painful neuropathy AE AG, YH a sensory neuropathy AE which shows a painful neuropathy characterized by damage to sensory and motor nerves abnormal stool AE According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal stools' was mentioned in 111 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). a digestive system AE which has an outcome of abnormal stool YH bone pain AE 10006002 NCIt:C38644 YH, MW CTCAE:E12392 SIDER: C0151825 a pain AE that has an outcome of bone pain HPO: HP_0002653 According to the Vaccine Adverse Event Reporting System (VAERS), 'bone pain' was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). cerebrovascular accident AE 10008190 HPO: HP_0001297 YH stroke SIDER: C0038454 Cerebrovascular accident: The sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A CVA is also referred to as a stroke. a cardiovascular disorder AE that comes with cerebrovascular accident parotid gland enlargement AE 10034023 a digestive system AE which has an outcome of parotid gland enlargement According to the Vaccine Adverse Event Reporting System (VAERS), 'parotid gland enlargement' was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH flatulence AE 10016766 YH a movement disorder AE that has an outcome of flatulence CTCAE: E10697 SIDER: C0016204 NCIt: C37954 Flatulence is the production of a mixture of gases in the digestive tract of mammals or other animals that are byproducts of the digestion process. Such a mixture of gases is known as flatus, and is expelled from the rectum in a process colloquially referred to as "passing gas" or "farting". HPO: HP_0011024 According to the Vaccine Adverse Event Reporting System (VAERS), 'flatulence' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). liver damage AE a liver/biliary system AE which has an outcome of liver damage YH According to the Vaccine Adverse Event Reporting System (VAERS), 'liver damage' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). sore throat AE 10041367 CTCAE: E13575 NCIt: C50747 a respiratory system AE which has an outcome of sore throat YH, MW paralysis AE 10033799 a movement disorder AE that results in the loss of power of voluntary movement in a muscle through injury or disease of its nerve supply HPO: HP_0010549 SIDER: C0522224 MP: MP_0000753 瘫痪 WEB: https://www.nlm.nih.gov/medlineplus/paralysis.html SS, YH According to the Vaccine Adverse Event Reporting System (VAERS), 'paralysis' is an adverse event that was mentioned in 574 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). aseptic necrosis bone AE 10003460 DJ, SS, YH a bone disorder AE that has an outcome of cellular death of bone components due to interupption of blood supply WEB: http://medical-dictionary.thefreedictionary.com/avascular+necrosis weight loss AE 10047895 10047900 NCIt: C3445 MP: MP_0001263 CTCAE: E12228 MW, YH weight decreased AE a physical examination result abnormal AE that has an outcome of weight loss, which is the progressive reduction of body weight below normal average for age ataxia AE 10003591 CTCAE:E12597 SIDER: C0004134 HPO: HP_0001251 a movement disorder AE that has an outcome of ataxia, inability to coordinate voluntary muscular movements According to the Vaccine Adverse Event Reporting System (VAERS), 'ataxia' is an adverse event that was mentioned in 555 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH, MW NCIt:C26702 MP: MP_0001393 skin AE 10040831 WEB: http://www.thefreedictionary.com/skin+disorder a hair, skin, and nail AE that occurs in skin. YH abnormal gait AE 10017577 gait disturbance AE NCIt: C78303 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21224774 According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal gait' is an adverse event that was mentioned in 998 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). a movement disorder AE that has an outcome of unusual or distinctive way of walking SS, YH CTCAE: E11112 MP: MP_0001406 dehydration AE 10012174 hypohydration an abnormal fluid regulation AE which has an outcome of dehydration, which is an excessive water loss from the body or from an organ or bodily part CTCAE:E12258 YH, SS, MW MP: MP_0001429 NCIt:C26740 SIDER: C0011175 HPO: HP_0001944 abnormal fluid regulation AE MP: MP_0001784 a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid hyperglycemia AE 10020635 10020639 MP: MP_0001559 WEB: http://medical-dictionary.thefreedictionary.com/hyperglycemia a glucose homeostasis AE which has an outcome of hyperglycemia, which is an abnormally high concentration of glucose in the blood; generally refers to a pathological state CTCAE: E12276 YH, MW NCIt: C26797 abnormal circulating bilirubin level AE a homeostasis AE which has an outcome of abnormal ciculating bilirubin level, which is aberrant concentration in the blood of this yellow heme breakdown product According to the Vaccine Adverse Event Reporting System (VAERS), 'bilirubinemia'; is an adverse event that was mentioned in 221 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001569 cyanosis AE 10011703 According to the Vaccine Adverse Event Reporting System (VAERS), 'cyanosis' is an adverse event that was mentioned in 1,804 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). SIDER: C0010520 MP: MP_0001575 HPO: HP_0000961 a skin adverse event that has an outcome of cyanosis, a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood anemia AE 10002034 10002272 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001586/ a hematopoietic system AE which has an outcome of anemia, which is less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs NCIt: C2869 anaemia AE MP: MP_0001577 CTCAE: E10010 hypotension AE 10005734 10021097 HPO: HP_0002615 NCIt: C3128 YH, MW CTCAE: E13791 blood pressure decreased, low blood pressure MP: MP_0001596 an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states SIDER: C0020649 irregular heartbeat AE MP: MP_0001636 an arrhythmia AE that has an outcome of uneven timing of heart contraction electrolyte blood test abnormal AE an electrolyte lab test abnormal AE that shows an abnormal level of an electrolyte in the blood YH, MW abnormal digestion AE MP: MP_0001664 a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy homeostasis AE an AE that occurs in the homeostasis system. anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues MP: MP_0001764 edema AE 10016807 10030095 10042674 MP: MP_0001785 WEB: http://en.wikipedia.org/wiki/Oedema an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues oedema, swelling, dropsy WEB: http://en.wikipedia.org/wiki/Swelling_(medical) inflammation AE 10061218 SIDER: C0021368 SS, YH HPO: HP_0007891 WEB: http://en.wikipedia.org/wiki/Inflammation MP: MP_0001846 an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult. brain inflammation AE According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001847 an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain increased susceptibility to otitis media AE an ear disorder AE which has an outcome of increased susceptibility to otitis media, which is greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection MP: MP_0001850 eye inflammation AE 10015943 MP: MP_0001851 HPO: HP_0100533 an eye disorder AE which has an outcome of eye inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the eye SIDER: C0239429 conjunctivitis AE 10010741 an eye inflammation AE which has an outcome of conjunctivitis, which is inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball SIDER: C0009763 NCIt: C34504 MP: MP_0001852 HPO: HP_0000509 CTCAE: E10355 liver inflammation AE YH, JX MP: MP_0001860 According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatitis' was mentioned in 387 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). an inflammation AE that shows a local accumulation of fluid, plasma proteins, and leukocytes in the liver lung inflammation AE According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001861 aa inflammation AE which has an outcome of lung inflammation, a local accumulation of fluid, plasma proteins, and leukocytes in the lung respiratory system inflammation AE MP: MP_0002405 an inflammation AE which occurs in the respiratory system, which is reflected with the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system vasculitis AE 10047115 NCIt:C26912 MP: MP_0001864 CTCAE:E13837 YH, MW HPO: HP_0002633 an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel SIDER: C0042384 It's an inflammation. salivary gland inflammation AE MP: MP_0001870 an inflammation AE which has an outcome of salivary gland inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland sinusitis AE 10040753 SS, YH, RR CTCAE: E11563 According to the Vaccine Adverse Event Reporting System (VAERS), 'sinusitis'; is an adverse event that was mentioned in 298 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001872 WEB: http://en.wikipedia.org/wiki/Sinusitis a respiratory system inflammation AE which has an outcome of sinus inflammation, an inflammation of paranasal sinuses, which may be due to infection, allergy, or autoimmune issues. sinus inflammation AE HPO: HP_0000246 SIDER: C0037199 NCIt: C35024 allergy AE 10001718 10001738 anaphylactic reaction AE allergic reaction AE CTCAE: E11248 MP: MP_0001878 过敏反应 NCIt: C3114 WEB: http://en.wikipedia.org/wiki/Allergy allergic response AE JX, LW, YH a hypersensitivity AE which results in an allergic response showing a marked increase in reactivity to an antigen upon subsequent exposure. 变态反应 abnormal cerebrospinal fluid production AE MP: MP_0001911 a nervous system AE which has an outcome of abnormal cerebrospinal fluid production, an anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord nervous system AE 10029202 KY, YH an AE that occurs in nervous system. MP: MP_0003633 nervous system disorder AE URL: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/overview_of_nervous_system_disorders_85,P00799/ abnormal respiration AE Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He MP: MP_0001943 According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung apnea AE respiratory arrest AE JX, YH, MW NCIt: C26698 MedDRA: 10002974 is for "apnoea"; MedDRA: 10002972 is for "apnea". According to the Vaccine Adverse Event Reporting System (VAERS), 'apnea' is an adverse event that was mentioned in 1,618 VAERS reports (1.3%) during1991-2001 (Reference: PMID: 12825543). CTCAE: E13306 apnoea AE UMLS CUI: C0003578 WEB: http://medical-dictionary.thefreedictionary.com/apnea MP: MP_0001957 an abnormal respiration AE which has an outcome of apnea, temporary cessation of breathing; sometimes episodic deafness AE 10011878 MP: MP_0001967 HPO: HP_0000365 SIDER: C0011053 an ear disorder AE which has an outcome of deafness, which is an inability to hear gustatory system AE MP: MP_0001985 YH, JX an adverse event that occurs in a gustatory system taste sensitivity AE MP: MP_0001986 a gustatory system AE which has an outcome of taste sensitivity, or changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system polyuria AE 10036142 WEB: http://en.wikipedia.org/wiki/Polyuria LW, ML, JX, YH a urinary system AE that has an outcome of excessive or abnormally large production or passage of urine. 多尿 blindness AE 10005169 SIDER: C0456909 HPO: HP_0000618 MP: MP_0002001 an abnormal vision AE which has an outcome of blindness, which is loss of the sense of sight abnormal vision AE MP: MP_0002090 an eye disorder AE which has an outcome of abnormal vision, which is an inability or decreased ability to see seizure AE 10039906 10039910 CTCAE: E12804 WEB: http://www.healthline.com/symptom/seizures 突然发作 YH, JX, YH MP: MP_0002064 NCIt: C2962 a behavior and neurological AE that shows a sudden surge of electrical activity in the brain. behavioral and neurological AE WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/ YH, JX any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls behavior AE disruptive behavioral disorder AE MP: MP_0004924 an adverse event that has an outcome of an abnormal behavior and neurological phenotype. behavioral AE behavioral disorder AE movement disorder AE 10028035 HPO: HP_0100022 SIDER: C0026650 MP: MP_0002066 a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements sensory capability AE MP: MP_0002067 a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus glucose homeostasis AE MP: MP_0002078 a homeostasis AE which has an outcome of glucose homeostasis, which is an anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues hypersensitivity AE 10020751 HPO: HP_0100326 WEB: http://en.wikipedia.org/wiki/Hypersensitivity Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal. JX, LW, YH hypersensitivity reaction AE 超敏反应 SIDER: C0020517 MP: MP_0002148 muscular atrophy AE YH MP: MP_0002269 Muscle atrophy is a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation. a muscle adverse event AE which has an outcome of muscular atrophy. hyperventilation AE 10020910 According to the Vaccine Adverse Event Reporting System (VAERS), 'Petechiae' was mentioned in 510 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). SIDER: C0020578 HPO: HP_0002883 MP: MP_0002320 an abnormal respiration AE which has an outcome of hyperventilation, i.e., increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal hypoventilation AE 10021133 10038678 respiratory depression AE HPO: HP_0007110 MP: MP_0002321 WEB: https://en.wikipedia.org/wiki/Hypoventilation QL, YH According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoventilation' is an adverse event that was mentioned in 321 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). SIDER: C0398353 呼吸抑制 an abnormal respiration AE which has an outcome of hypoventilation, i.e., reduced alveolar ventilation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal hematopoietic system AE MP: MP_0002396 an adverse event which occurs in a hematopoietic system, which is any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells mydriasis AE 10028521 HPO: HP_0011499 SIDER: C0026961 MP: MP_0002546 an eye disorder AE which has an outcome of mydriasis, which is dilation of one or both pupils regardless of light conditions increased heart rate AE 10019303 WEB: http://en.wikipedia.org/wiki/Tachycardia an arrhythmia AE that has an outcome of greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute tachycardia MP: MP_0002626 hyperresponsive to tactile stimuli AE MP: MP_0002738 a behavior and neurological AE that has an outcome of exaggerated reflex action opisthotonus AE 10030899 YH a muscle spasm AE that has an outcome of opisthotonus MP: MP_0002880 SIDER: C0151818 HPO: HP_0002179 opisthotonus is a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward joint inflammation AE An joint disorder AE that has an outcome of joint inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the joints MP: MP_0002933 YH increased lactate dehydrogenase level AE MP: MP_0002944 an abnormal enzyme level AE which has an outcome of incraesed lactate dehydrogenase level, which is greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate increased circulating alkaline phosphatase level AE MP: MP_0002968 an abnormal enzyme level AE which has an outcome of increased circulating alkaline phophatase level, which is an elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood arthritis AE 10003246 A joint inflammation AE that has an outcome of arthritis, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures SIDER: C0003864 CTCAE:E12378 HPO: HP_0001369 MP: MP_0002993 NCIt:C2883 YH, MW 关节炎 dysphagia AE 10013950 SIDER: C0011168 NCIt: C2980 CTCAE: E10621 HPO: HP_0002015 MP: MP_0003158 a digestive system AE which has an outcome of dysphagia, which is a behavior and neurological AE that has an outcome of difficulty in swallowing food or liquid decreased lateral semicircular canal size AE MP: MP_0003162 an ear disorder AE which has an outcome of decreased lateral semicircular canal size, which is small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance platelet count decreased AE 10035528 HPO: HP_0001873 MP: MP_0003179 NCIt: C3408 CTCAE: E12207 SS, YH SIDER: C0392386 a hematopoietic system AE which has an outcome of decreased platelet count, which is fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation decreased platelet cell number AE nausea AE 10028813 CTCAE: E10878 NCIt: C3258 MP: MP_0003259; MDR: 10028813 HPO: HP_0002018 SIDER: C0027497 an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit vomiting AE 10047700 NCIt: C3442 SIDER: C0042963 MP: MP_0003260; MDR: 10047700 regurgitation AE CTCAE: E11068 HPO: HP_0002013 an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity constipation AE 10010774 CTCAE: E10562 MP: MP_0003267 infrequent bowel movements AE SIDER: C0009806 NCIt: C37930 HPO: HP_0002019 According to the Vaccine Adverse Event Reporting System (VAERS), 'constipation'; is an adverse event that was mentioned in 242 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). an abnormal defecation AE that has an outcome of constipation, which is incomplete, infrequent or difficult evacuation of fecal matter abnormal defecation AE MP: MP_0003866 a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces urinary incontinence AE MP: MP_0003280 HPO: HP_0000020 SIDER: C0042024 YH, MW MedDRA: 10046543 CTCAE: E13042 NCIt: C78497 WEB: http://www.nlm.nih.gov/medlineplus/urinaryincontinence.html a urinary system AE that has an outcome of the symptom of urinary incontinence, which is the inability to control the urinary excretory functions. clonus AE 10009346 WEB: http://en.wikipedia.org/wiki/Clonus clonus AE causes large motions that are usually initiated by a reflex. SJ, YH clonus AE is a series of involuntary, rhythmic, muscular contractions and relaxations. pallor AE 10033546 MP: MP_0003717 SIDER: C0030232 HPO: HP_0008361 a skin discoloration AE which has an outcome of pallor, an unnatural paleness to the skin, generally attributable to anemia tinnitus AE 10043882 HPO: HP_0000360 MP: MP_0003741 CTCAE: E10287 NCIt: C50772 SIDER: C0040264 an hearing disorder AE that shows a persistent sensation of buzzing, ringing, clicking, or other noises in the ear stomatitis AE 10042128 MP: MP_0003746 SIDER: C0038362 This is a type of inflammation. HPO: HP_0010280 WEB: http://medical-dictionary.thefreedictionary.com/stomatitis a digestive system AE which has an outcome of stomatitis, which is an inflammation of the mucous lining of the mouth mouth mucosal ulceration AE MP: MP_0003747 According to the Vaccine Adverse Event Reporting System (VAERS), 'mouth ulceration' was mentioned in 246 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). a digestive system AE which has an outcome of mouth mucosal ulceration, which is lesions through the mucous membrane of the mouth, usually associated with loss of tissue abnormal muscle tone AE MP: MP_0004142 YH a muscle adverse event AE that has an outcome of abnormal muscle tone, which is an anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation hypertonia AE 10020852 SIDER: C0026826 HPO: HP_0001276 MP: MP_0004143 YH an abnormal muscle tone AE which has an outcome of hypertonia, which is increased muscle tension resulting in stiffness of the muscles in the resting state hypotonia AE 10021118 SIDER: C0026827 YH HPO: HP_0009062 MP: MP_0004144 an abnormal muscle tone AE which has an outcome of hypotonia, which is decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness myositis AE 10028653 MP: MP_0004510 NCIt:C27578 YH, MW CTCAE:E12489 HPO: HP_0009071 SIDER: C0027121 a muscle inflammation AE which has an outcome of myositis, which is an inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle muscle inflammation AE YH MP: MP_0004511 a muscle adverse event which has an outcome of muscle inflammation, which is a local accumulation of fluid, plasma proteins, and leukocytes in muscle lymphocyte count increased AE 10025258 MP: MP_0005013 increased lymphocyte cell number AE NCIt: C34791 EB According to the Vaccine Adverse Event Reporting System (VAERS), 'lymphocytosis'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). lymphocyte cell number increased AE CTCAE: E12195 a lymphocyte count abnormal AE that has an outcome of greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells diarrhea AE 10012735 NCIt: C2987 diarrhoea AE MP: MP_0005036 WEB: http://medical-dictionary.thefreedictionary.com/diarrhea CTCAE: E10572 an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel hypoxia AE 10021143 YH, MW MP: MP_0005039 WEB: http://medical-dictionary.thefreedictionary.com/hypoxia SIDER: C0242184 CTCAE:E13388 NCIt:C3890 HPO: HP_0002795 a homeostasis AE which has an outcome of hypoxia, which is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases sepsis AE 10040047 HPO: HP_0002718 CTCAE: E11560 SIDER: C0243026 According to the Vaccine Adverse Event Reporting System (VAERS), 'sepsis' was mentioned in 416 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0005044 SS NCIt: C3364 an infectious adverse event which has an outcome of the presence of various pathogenic organisms, or their toxins, in the blood or tissues that results in the infections in blood stream. hematuria AE 10018867 10018870 10019450 MP: MP_0005161 YH, SJ, MW WEB: http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/ NCIt: C3090 a urinary system AE that results in the presence of blood in the urine blood urine blood urine presence haematuria AE UMLS CUI: C0018965 (hematuria AND haematuria); UMLS CUI: C0947999 (blood urine presence) CTCAE: E13000 Hematuria AE can be caused by menstruation, vigorous exercise, sexual activity, viral illness, trauma, or infection, such as a urinary tract infection (UTI), along with more serious disorders such as cancer, disease, and clotting. abnormal enzyme level AE MP: MP_0005319 a homeostasis AE which has an outcome of abnormal enzyme level, which is an altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances decreased heart rate AE 10019301 an arrhythmia AE that has an outcome of fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute YH, JX heart rate decreased AE MP: MP_0005333 urinary system AE MP: MP_0005502 YH an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine hypothermia AE 10021113 YH, SJ decreased body temperature AE CTCAE: E11122 MP: MP_0005534 Hypothermia AE is a medical emergency that occurs when your body loses heat faster than it can produce heat, causing a dangerously low body temperature. NCIt: C78351 an abnormal body temperature AE which has an outcome of decreased body temperature, which is less than the level of heat natural to a living being abnormal body temperature AE MP: MP_0005535 a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being neuritis AE 10029240 MP: MP_0006082 a peripheral neuropathy AE which has an outcome of neuritis, the local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord double vision AE 10013036 diplopia AE MP: MP_0006150 an abnormal vision AE which has an outcome of double vision, which is two images perceived when only a single object is present hypochromic anemia AE MP: MP_0008387 an anemia AE which has an outcome of hypochromic anemia, which is a hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs investigation result abnormal AE 10061253 EB, SS, YH This term is used to replace 'lab test abnormal AE'. The reason for this is that some test, like X-ray test, is not considered by many physicians as a lab test. Therefore, we have used this new term to cover a broader scope. All terms asserted under this term represent the investigation results without defined conclusion of disease. laboratory test abnormal an adverse event that is indicated by an abnormal result of an investigation that uses some laboratory equipment, device, or medical technology. nervous AE MP: MP_0008912 a movement disorder AE that has an outcome of nervous According to the Vaccine Adverse Event Reporting System (VAERS), 'nervousness' is an adverse event that was mentioned in 583 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). increased, skittish, behavior induced by stimulation such as handling, touching or noise ecchymosis AE 10014080 MP: MP_0009276 HPO: HP_0000978 a hemorrhage AE that has an outcome of ecchymosis SIDER: C0013491 an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis serious adverse event serious adverse event WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm WEB: http://en.wikipedia.org/wiki/Serious_adverse_event YH, MC severe adverse event serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death. death AE 10011906 10011914 a serious adverse event that has an outcome of death. HPO: HP_0001645 NCIt: C28554 SIDER: C1306577 YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm CTCAE: E11080 life-threating AE 10065044 DJ, SS, YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm apparent life threatening event AE a serious AE that is suspected to put the patient at substantial risk of dying at the time of the adverse event, or that the use or continued use of the device or other medical product might have resulted in the death of the patient. hospitalization AE a serious adverse event that leads to hospitalization. Such an adverse event resulted in an admission to the hospital or prolongation of hospitalization. adverse event leading to hospitalization YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm disability or permanent damage AE WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm adverse event leading to disability a serious adverse event that leads to disability or permanent damage. Such an adverse event results in a substantial disruption of a person's ability to conduct normal life functions, i.e., the adverse event resulted in a significant, persistent or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities and/or quality of life. YH, JX congenital anomaly or birth defect AE 10010356 adverse event leading to congenital anomaly WEB: http://www.thefreedictionary.com/birth+defect WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm a serious adverse event that resulted in congenital anomaly and bith defect, leading to suspicions that an exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child. YH, JX adverse event that requires intervention to prevent permanent impairment or damage a serious adverse event which is an adverse event that requires intervention to prevent permanent impairment or damage leads to suspicions that the use of a medical product may result in a condition which requires a medical or surgical intervention to preclude permanent impairment or damage to a patient. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm non-serious adverse event WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA YH, MC an adverse event that is considered not serious. low-grade fever AE WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 The low-grade level of fever is beneficial. With most microbes/"bugs" that a child will be exposed to, this fever will assist the body in repelling the invader. YH low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C). moderate-grade fever AE YH This moderate-grade fever temperature is still considered beneficial. If a child's body has reached this temperature, it's what's needed to kill whatever bacteria or virus their body is attempting to fight. moderate-grade fever AE is a fever adverse event with a temperature typically between 102.2° F and 104.5° F (39° C and 40° C). WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 high-grade fever AE This fever may cause the child some discomfort and result in crankiness. Generally indicative of a bacterial infection, this fever means that the body is fighting something more serious than the common cold. WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521 YH high-grade fever AE is a fever adverse event with a fever temperature greater than 104.5° F (40° C). hyperpyrexia AE 10020741 extreme pyrexia AE YH Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828. SIDER: C0392676 HPO: HP_0001945 hyperpyrexia AE is a fever adverse event that has an outcome of an excessive and unusual elevation of set body temperature greater than or equal to 41 °C. It is an extremely high fever. Such a high temperature is considered a medical emergency as it may indicate a serious underlying condition such as sepsis. WEB: http://en.wikipedia.org/wiki/Hyperpyrexia musculoskeletal pain AE 10028391 Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones. WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain a pain AE that has an outcome of musculoskeletal pain HPO: HP_0003326 SS, YH SIDER: C0026858 injection-site erythema AE 10022061 SS, YH injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection WEB: http://en.wikipedia.org/wiki/Erythema WEB: http://medical-dictionary.thefreedictionary.com/erythema erythema AE 10015150 WEB: http://en.wikipedia.org/wiki/Erythema HPO: HP_0010783 reddish skin SS, YH SIDER: C0041834 Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin. MP:0001190 sinus headache AE sinus headache is a headache located over the sinuses, (forehead, corners of the eye, and cheek areas). On occasion, the pain will be felt behind the eyes, in the back of the neck, or may extend into the upper teeth. YH, SS WEB: http://american-rhinologic.org/patientinfo.headache.phtml HPO: HP_0002315 SIDER: C0037195 a headache AE that has an outcome of sinus headache pneumonia AE 10035664 an inflammation AE that occurs in the lung. It is often characterized as including inflammation of the parenchyma of the lung (that is, the alveoli) and abnormal alveolar filling with fluid (consolidation and exudation). WEB: http://en.wikipedia.org/wiki/Pneumonia HPO: HP_0002090 SS, YH SIDER: C0032285 lobar pneumonia AE 10024738 SIDER: C0032300 lobar pneumonia is pneumonia AE that affects a large and continuous area of the lobe of a lung SS, YH WEB: http://en.wikipedia.org/wiki/Lobar_pneumonia HPO: HP_0002090 axillary pain AE axillary pain AE is a pain AE that occurs in the underarm (the area on the human body directly under the join where the arm connects to the shoulder) SS, YH hematoma AE 10006504 10018852 10019428 SS, YH bruising AE an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. SIDER: C0018944 YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma". WEB: http://en.wikipedia.org/wiki/Hematoma HPO: HP_0001892 CTCAE: E13775 (hematoma); CTCAE: E11666 (brruising) ecchymoses AE NCIt: C37921 (Bruising); NCIt: C50579 (Hematoma) bruise AE haematoma AE reproductive system AE YH, SS reproductive system AE is an AE that occurs in the reproductive system. antinuclear antibody negative AE an immune system disorder AE which has an outcome of antinuclear antibody negative SS, YH CSF white blood cell count negative AE 10061099 SS, YH, EB a CSF test result abnormal AE that has an outcome of CSF white blood cell count negative influenza serology positive AE 10060078 a microbiology and serology investigation result abnormal AE that has an outcome of positive influenza serology test result SS, YH, EB VIIth nerve paralysis AE 10050040 HPO: HP_0006824 YH SIDER: C0919980 a paralysis AE that has an outcome of VIIth nerve paralysis aspartate aminotransferase level increased AE 10003481 DJ, SS, YH, EB CTCAE: E12087 WEB: http://medical-dictionary.thefreedictionary.com/aspartate+aminotransferase an aspartate aminotransferase level abnormal AE that has an outcome of an increased amount of AST, an enzyme normally present in body tissues especially of the heart and liver NCIt: C26947 accidental overdose in medical intervention 10000381 an incorrect dose administration that accidentally uses overdose SS, YH acute disseminated encephalomyelitis AE 10000709 WEB: http://en.wikipedia.org/wiki/Acute_disseminated_encephalomyelitis an immune system disorder AE which has an outcome of acute disseminated encephalomyelitis SS, YH Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually occurs following a viral infection but may appear following vaccination, bacterial or parasitic infection, or even appear spontaneously. As it involves autoimmune demyelination, it is similar to multiple sclerosis, and is considered part of the Multiple sclerosis borderline diseases. atrial fibrillation AE 10003658 WEB: http://medical-dictionary.thefreedictionary.com/atrial+fibrillation NCIt: C50466 AF SS, YH Atrial fibrillation (AF or A-fib) is the most common cardiac arrhythmia (abnormal heart rhythm), and involves the two upper chambers (atria) of the heart. Its name comes from the fibrillating (i.e., quivering) of the heart muscles of the atria, instead of a coordinated contraction. WEB: http://en.wikipedia.org/wiki/Atrial_fibrillation HPO: HP_0005110 SIDER: C0004238 CTCAE: E10081 an arrhythmia AE that involves the two upper chambers (atria) of the heart arrhythmia AE 10003119 SIDER: C0003811 abnormal heartbeat AE HPO: HP_0011675 cardiac arrhythmia AE a cardiac disorder AE which has an outcome of abnormal heart rhythm MP: MP_0004085 SS, YH WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/arr/ mitral valve stenosis AE 10027733 a cardiac valve disease AE that is characterized by a condition of the heart in which one of the valve openings has become narrow and restricts the flow of blood from the upper left chamber (left atrium) to the lower left chamber (left ventricle). WEB: http://medical-dictionary.thefreedictionary.com/mitral+valve+stenosis SS blood creatinine level decreased AE 10005482 SS, YH, EB a blood creatinine level abnormal AE that has an outcome of decreased blood creatine carbon dioxide decreased AE 10007223 a carbon dioxide abnormal AE that has an outcome of a decreased level of carbon dioxide in the blood SS, YH, EB contraindication to vaccination SS, YH A contraindication that is specifically for vaccination. croup infection AE an infection adverse event that has an outcome of croup infection SS, YH WEB: http://www.medicinenet.com/croup/article.htm Croup is an infectious illness of the respiratory system involving the vocal cords (larynx), the windpipe (trachea), and the upper airways of the lungs (bronchial tubes). The majority of a child's symptoms reflect involvement of the larynx. Croup is usually a viral infection and maybe caused by many different viruses, including those responsible for the common cold and influenza. Rarely, croup is caused by a bacterial infection. aspiration AE 10003504 HPO: HP_0002835 DJ, SS, YH, MW NCIt:C15631 CTCAE:E13310 a respiratory system AE that has an outcome of the drawing of a foreign substance into the respiratory tract during inhalation WEB: http://medical-dictionary.thefreedictionary.com/aspiration SIDER: C0700198 aspiration pleural cavity AE 10003522 WEB: http://medical-dictionary.thefreedictionary.com/aspiration a respiratory system AE that has an outcome of the removal of gas or fluid from the pleural cavity of the lungs DJ, SS, YH excoriation AE 10049796 WEB: http://medical-dictionary.thefreedictionary.com/excoriation SS, YH a skin adverse event which has an outcome of excoriation AE is an injury to a surface of the body caused by trauma, such as scratching, abrasion, or a chemical or thermal burn. facial pain AE 10016059 a pain AE that has an outcome of facial pain facial pain is a pain in facial area (eyes, eyebrows, forehead, nose, cheeks, mouth, teeth and chin). Facial pain may include injuries to the nerves or bones that coordinate many of your face’s actions. SS, YH WEB: http://www.bettermedicine.com/article/facial-pain CTCAE: E11094 HPO: HP_0100661 SIDER: C0015468 NCIt: C79594 full blood count abnormal AE 10017412 10064198 a hematology investigation result abnormal AE that has an outcome of abnormal full blood count SS, YH, EB obsolete: hyporeflexia AE 10021089 a reflexes decreased AE that has an outcome of hyporeflexia SIDER: C0151888 HPO: HP_0009072 Obsoleted because of duplication hyporeflexia is the condition of below normal or absent reflexes. Hyporeflexia is generally associated with a lower motor neuron deficit (at the alpha motor neurons from the spinal cord to muscle). SS, YH WEB: http://en.wikipedia.org/wiki/Hyporeflexia astrocytoma AE 10003571 HPO: HP_0009592 WEB: http://medical-dictionary.thefreedictionary.com/astrocytoma DJ, SS, YH a tumor AE that is characterized by cancer in the brain SIDER: C0004114 incorrect dose administration 10064355 SS, YH a medical intervention that uses incorrect dose atelectasis AE 10003598 HPO: HP_0001642 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001130/ CTCAE:E13316 NCIt:C2888 a lung disorder AE that has an outcome of collapse in part of or all of a lung DJ, SS, YH, MW SIDER: C0004144 influenza virus test positive AE 10070717 SS, YH, EB an influenza serology positive AE that has an outcome of positive result in an influenza virus test joint range of motion decreased AE 10048706 NCIt: C78403 CTCAE: E12435 joint range of motion decreased AE is a mobility decreased AE that results in limited or decreased range of joint motion SS, YH, MW laryngospasm AE 10023891 a muscle spasm AE which has an outcome of laryngospasm, which is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. The condition typically lasts less than 60 seconds, and causes a partial blocking of breathing in, while breathing out remains easier. It may be triggered when the vocal cords or the area of the trachea below the cords detects the entry of water, mucus, blood, or other substance. It is characterized by stridor and or retractions. SS, YH, MW HPO: HP_0006511 WEB: http://en.wikipedia.org/wiki/Laryngospasm NCIt:C79609 CTCAE:E13439 SIDER: C0023066 lymphocyte percentage decreased AE 10052231 a lymphocyte percentage abnormal AE that has an outcome of decreased lymphocyte percentage SS, YH, EB monocyte percentage increased AE 10052230 a monocyte percentage abnormal AE that has an outcome of increased monocyte percentage SS, YH, EB nuclear magnetic resonance imaging brain abnormal AE 10029818 a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the brain SS, YH periorbital edema AE periorbial edema AE is an edema AE that has an outcome of swelling around the eye. NCIt: C78530 Periorbital puffiness, also known as "puffy eyes" or swelling around the eyes, refers to the appearance of swelling in the tissues around the eyes, called the orbits. WEB: http://en.wikipedia.org/wiki/Periorbital_puffiness CTCAE: E13676 UMLS CUI: C0151205 periorbital oedema AE SS, YH MedDRA: 10034545 is for "periorbital edema"; MedDRA: 10054541 is for "periorbital oedema" periorbital puffiness pregnancy test positive 10036556 10036575 a physical quality of a process that shows a positive result of a pregnancy test. SS, YH hypermagnesemia AE 10020670 YH, MW WEB: http://emedicine.medscape.com/article/246489-overview a blood magnesium abnormal AE that has an outcome of an abnormally high concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors. NCIt: C37969 CTCAE: E12288 UMLS CUI: C0151714 sensation of foreign body AE 10061549 SS, YH a sensory capability AE that has an outcome of a sensation feeling of foreign body sensation of heaviness AE a sensory capability AE that has an outcome of a sensation feeling of heaviness feeling heavy AE SS, YH sensory loss AE 10040030 SS, YH SIDER: C0278134 a sensory capability AE that has an outcome of a loss of sensation HPO: HP_0003474 skin exfoliation AE 10040844 a skin adverse event that has an outcome of skin exfoliation SIDER: C0237849 SS, YH HPO: HP_0007549 stomach discomfort AE 10042124 stomach upset AE SS, YH 胃部不适 a digestive system AE which has an outcome of stomach discomfort autoantibody positive AE 10060973 an immunology and allergy investigation result abnormal AE that has an outcome of autoantibodies present DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/autoantibody stridor AE 10042241 a wheezing AE which has an outcome of stridor, a high pitched wheezing sound resulting from turbulent air flow in the upper airway. It is primarily inspiratory. It can be indicative of serious airway obstruction from severe conditions such as epiglottitis, a foreign body lodged in the airway, or a laryngeal tumor. SS, YH, MW SIDER: C0038450 NCIt:C78632 CTCAE:E13579 WEB: http://en.wikipedia.org/wiki/Stridor HPO: HP_0010307 skin ulceration AE 10040943 10040947 SIDER: C0037299 skin ulcer AE WEB: http://en.wikipedia.org/wiki/Ulcer_%28dermatology%29 HPO: HP_0200042 NCIt: C54247 CTCAE: E13730 a skin AE that shows a result of skin ulcer, i.e., a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. SS, YH, MW underdose adminstration in medical intervention SS, YH an incorrect dose administration that uses underdose upper respiratory tract congestion AE a respiratory tract congestion AE which has an outcome of upper respiratory tract congestion SS, YH urine analysis result abnormal AE 10062226 SS, YH, EB a urinary system investigation result abnormal AE that has an outcome of a urine analysis abnormality urine ketone body present AE 10057597 a urine analysis result abnomal AE that shows ketone body present in urine SS, YH, EB, QL autoimmune hepatitis AE 10003827 SIDER: C0241910 HPO: HP_0004787 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001291/ a liver/biliary system AE that has an outcome of inflammation of the liver that occurs when immune cells mistake the liver's normal cells for harmful invaders and attack them DJ, SS, YH vaginal hemorrhage AE NCIt: C26945 CTCAE: E13264 MedDRA: 10046910 is for "vaginal haemorrhage"; MedDRA: 10046912 is for "vaginal hemorrhage" vaginal hemorrhage is irregular/heavy bleeding from the vagina. Vaginal hemorrhage is more often associated with pregnancy complications such as miscarriage or placental abruption, but certainly can occur in the absence of pregnancy. a hemorrhage AE that has an outcome of vaginal hemorrhage SS, YH, MW WEB: http://www.brooksidepress.org/Products/Military_OBGYN/Textbook/AbnormalBleeding/Bleeding.htm vaginal haemorrhage AE vasodilatation AE a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. WEB: http://en.wikipedia.org/wiki/Vasodilation SS, YH HPO: HP_0004927 SIDER: C0595862 bacteremia AE 10003997 a bacterial infection AE that has an outcome of bacteria in the blood WEB: http://medical-dictionary.thefreedictionary.com/bacteremia DJ, SS, YH bacteraemia AE bacterial sepsis AE 10053840 WEB: http://medical-dictionary.thefreedictionary.com/sepsis DJ, SS, YH a sepsis AE caused by bacterial infection in the bloodstream or body tissues basal cell carcinoma AE 10004146 HPO: HP_0002671 a skin AE that has an outcome of a slow-growing nonmelanoma skin cancer DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001827/ SIDER: C0007117 basophil count increased AE 10004169 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/basophil+granulocyte a basophil count abnormal AE that is characterized by increase in the number of basophils in the body behcet's syndrome AE 10004213 WEB: http://medical-dictionary.thefreedictionary.com/behcet's+disease an ulcer AE that is characterized by ulcers in the mouth that may decrease ocular functionality DJ, SS, YH benign congenital hypotonia AE 10051900 a musculoskeletal system AE that has an outcome of low muscle tone DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hypotonia benign hydatidiform mole AE 10004272 a female reproductive system AE that has an outcome of a non-fertilized egg that implants itself in the uterus and turns a normal pregnancy into an abnormal one WEB: http://medical-dictionary.thefreedictionary.com/hydatidiform+mole DJ, SS, YH benign ovarian tumor AE 10004433 DJ, SS, YH a benign tumor AE that has an outcome of a benign tumor in their ovaries benign ovarian tumour AE bile duct obstruction AE 10056375 a digestive system AE that has an outcome of a blockage in the tubes that carry bile from the liber to the gallbladder and small intestine DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000263.htm biliary dilatation AE 10057202 DJ, SS, YH a liver/biliary system AE that has an outcome of dilating or stretching of the bile duct WEB: http://www.ncbi.nlm.nih.gov/pubmed/21843715 binge eating AE 10004716 an eating disorder that is characterized by episodes of uncontrollable eating. DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/binge+eating binocular eye movement disorder AE 10061010 DJ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/23201436 Secondary Source: http://brain.oxfordjournals.org/content/119/6/1933.full.pdf an eye disorder AE that has an outcome of binocular eye movement disorder where control and alignment of eyes are compromised bladder cancer AE 10005003 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001517/ a digestive system AE that has an outcome of cancer that starts in the bladder, the body part that holds and releases urine in the center of the lower belly area SIDER: C0005684 DJ, SS, YH HPO: HP_0009725 blast cell count increased AE 10062274 WEB: http://meds.queensu.ca/medicine/deptmed/hemonc/anemia/blast.htm a blast cell count abnormal AE that has an outcome of an increased amount of immature precursors of either lymphocytes or granulocytes that do not normally appear in peripheral blood. May indicate acute leukemia DJ, SS, YH blast cell crisis AE 10053747 WEB: http://medical-dictionary.thefreedictionary.com/blast+crisis DJ, SS, YH a hematopoietic system AE that has an outcome of a sudden, severe change in the course of chronic granulocytic leukemia with an increase in the proportion of myeloblasts blast cells present AE 10057107 a hematopoietic system AE that has an outcome of myeloblasts or myeloid blasts. Presence of these abnormal blasts prevent production of adequate platelets, red blood cells and white blood cells, can be associated with leukemia WEB: http://lymphoma.about.com/od/glossary/ss/Blast-Cells.htm DJ, SS, YH blast crisis in myelogenous leukemia AE 10050282 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/blast+crisis , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23171293 DJ, SS, YH a hematopoietic system AE that has an outcome of the last stage of chronic myelogenous leukemia characterized by rapid progression and short survival with an increase of myeloblasts or lymphoblasts in the blood or bone marrow blast crisis in myelogenous leukaemia AE blepharitis AE 10005148 HPO: HP_0000498 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002586/ DJ, SS, YH an eye inflammation AE that has an outcome of swelling in the eyelids, usually where eyelash follicles are located SIDER: C0005741 blood albumin level decreased AE 10005287 DJ, SS, YH, EB hypoalbuminemia AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003480.htm a blood albumin level abnormal AE with an outcome of a decrease in the amount of albumin, a protein made by the liver blood alkaline phosphatase level abnormal AE 10059571 DJ, SS, YH, EB a liver related investigation result abnormal AE that has an outcome of an abnormal level of alkaline phosphatase in the blood blood alkaline phosphatase decreased AE 10059569 WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase DJ, SS, YH a blood alkaline phosphatase abnormal AE that has an outcome of a decreased level of alkaline phosphatase in the blood blood alkaline phosphatase increased AE 10001675 10059570 CTCAE: E12082 HPO: HP_0003155 SIDER: C0852911 a blood alkaline phosphatase abnormal AE that has an outcome of elevated levels of alkaline phosphatase, an enzyme responsible for removing phosphate groups. a liver/biliary system AE that has an outcome of an increased amount of ALP, an isoenzyme that removes phosphate groups commonly found in the bile ducts but also found in the bone DJ, SS, YH NCIt: C35607 WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase chronic inflammatory demyelinating neuropathy AE CIDP a distal neuropathy AE which shows a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. It is caused by the loss of myelin sheath of the peripheral nerves. AG, YH WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm Chronic Inflammatory Demyelinating Polyneuropathy blood amylase level increased AE 10005328 10040139 DJ, SS, YH, EB CTCAE: E12212 serum amylase increased AE NCIt: C78608 a blood amylase level abnormal AE that has an outcome of an increased amount of amylase, an enzyme that helps digest carbohydrates; may indicate disease or inflammation of the pancreas WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003464.htm blood bilirubin level abnormal AE 10058477 a liver related investigation result abnormal AE that has an outcome of an abnormal amount of bilirubin in the blood DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/bilirubin blood bilirubin level increased AE 10005364 WEB: http://medical-dictionary.thefreedictionary.com/bilirubin a blood bilirubin level abnormal AE with an outcome of a increased amount of bilirubin, or a yellow breakdown product (broken down hemoglobin) of normal heme catabolism, in the blood DJ, SS, YH, EB CTCAE: E12096 NCIt: C27088 blood calcium decreased 10005395 a physical quality that has a decreased amount of calcium in the bloodstream DJ, SS, YH blood chloride decreased 10005419 SIDER: C0595902 WEB: http://www.medterms.com/script/main/art.asp?articlekey=9940 DJ, SS, YH A physical quality that has an decreased level of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease HPO: HP_0003113 blood cholesterol increased AE 10005425 HPO: HP_0003124 NCIt: C37967 CTCAE: E12127 DJ, SS, YH, EB SIDER: C0595930 a blood cholesterol abnormal AE with the result of an increase in cholesterol level in the blood blood creatine phosphokinase level abnormal AE 10005468 an enzyme investigation result abnormal AE that has an outcome of abnormal levels of creatine phosphokinase in the blood DJ, SS, YH, EB blood creatinine level increased AE 10005483 10011368 creatinine increased AE a blood creatinine level abnormal AE that has an outcome of an increased level of creatinine in the blood (due to lack of kidney activity) WEB: http://medical-dictionary.thefreedictionary.com/creatinine NCIt: C78249 serum creatinine increased CTCAE: E12137 DJ, SS, YH, EB blood culture positive AE 10005488 DJ, SS, YH an infection adverse event that has an outcome of bacteria or yeasts in the blood WEB: http://labtestsonline.org/understanding/analytes/blood-culture/tab/test blood disorder AE 10061590 DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/blooddisorders.html a hematopoietic system AE that has an outcome of disease in the blood, a living tissue made up of plasma and red blood cells, white blood cells and platelets. Blood disorders affect one or more parts of the blood and prevent the blood from doing this job. blood folate level decreased AE 10005527 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/folate a blood folate abnormal AE that has an outcome of a decreased level of folate in the blood blood glucose level decreased AE 10005555 DJ, SS, YH, EB a blood glucose level abnormal AE that has an outcome of a decrease of glucose levels in blood blood glucose level increased AE 10005557 a blood glucose level abnormal AE that has an outcome of an increased glucose level in blood DJ, SS, YH, EB blood homocysteine level increased AE 10049733 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/homocysteine a blood homocysteine level abnormal AE that has an outcome of an increased levels of homocysteine in the blood blood immunoglobulin A level increased AE 10005586 an immunology and allergy investigation result abnormal AE that results in an increased immunoglobulin a level in the blood WEB: http://medical-dictionary.thefreedictionary.com/immunoglobulin+A IgA level increased DJ, SS, YH, EB blood lactate dehydrogenase level increased AE 10005630 DJ, SS, YH, EB a blood lactate dehydrogenase level abnormal AE that has an outcome of an increased amount of LDH, an enzyme that could indicate tissue damage WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm blood magnesium decreased 10005654 HPO: HP_0002917 WEB: http://www.medterms.com/script/main/art.asp?articlekey=4243 A physical quality that has an decreased level of magnesium, a mineral involved in nerve signaling and bone health. Deficiency can cause spasms, and muscular cramps. SIDER: C0853750 DJ, SS, YH blood parathyroid hormone decreased AE 10005702 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/parathyroid+hormone a blood parathyroid hormone level abnormal AE that has an outcome of a decrease in the level of parathyroid hormone in the blood blood phosphorus decreased 10049471 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003478.htm HPO: HP_0002148 A physical quality that has an decreased level of decreased phosphorus in the blood SIDER: C0877517 DJ, SS, YH blood potassium decreased 10005724 HPO: HP_0002900 DJ, SS, YH, LW, MW 血钾下降 a physical quality where the blood potassium level is decreased. blood pressure diastolic decreased AE 10005737 a hypotension AE that has an outcome of a decrease in the amount of pressure in the arteries when the heart is at rest between beats DJ, SS, YH WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes blood pressure immeasurable AE 10005748 DJ, SS, YH a hypotension AE that has an outcome of immeasurable blood pressure blood sodium decreased 10005802 A physical quality that has an decreased level of sodium concentration in the blood DJ, SS, YH, MW blood thromboplastin level increased AE 10005827 a blood thromboplastin level abnormal AE that has an outcome of an increase in the level of thromboplastin in the blood WEB: http://medical-dictionary.thefreedictionary.com/thromboplastin DJ, SS, YH, EB blood urea level decreased AE 10005850 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/blood+urea+nitrogen a blood urea level abnormal AE with an outcome of a decreased amount of urea nitrogen in the blood, below 7 to 21 mg of urea per 100 ml blood urea level increased AE 10005851 DJ, SS, YH, EB a blood urea level abnormal AE that results in an increase in amount of urea in blood blood uric acid level increased AE 10005861 WEB: http://chemocare.com/chemotherapy/side-effects/hyperuricemia-high-uric-acid.aspx a blood uric acid level abnormal AE that has an outcome of an increase in uric acid in the blood; excess purines may accumulate in tissues and form crystals DJ, SS, YH, EB bone cyst AE 10005952 WEB: http://medical-dictionary.thefreedictionary.com/bone+cyst a bone disorder AE that has an outcome of a cyst that forms on the bone DJ, SS, YH bone debridement AE 10057612 DJ, SS, YH WEB: http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Osteomyelitis a bone disorder AE that has an outcome of surgery to clean and flush out the infected bone bone lesion AE 10061728 a bone disorder AE that has an outcome of an anomlay in the growth or structure of a bone WEB: http://www.ncbi.nlm.nih.gov/pubmed/20972590 DJ, SS, YH bone marrow depression AE 10005986 10048580 DJ, SS, YH, MW hypocellular bone marrow UMLS: C0151773 SIDER: C0151773 Bone marrow produces three types of blood cells; red blood cells, white blood cells and platelets. Bone marrow depression is characterized by an inability or reduced ability of the bone marrow to produce these cells. A low blood count can involve just one or all three types of blood cells. HPO: HP_0012145 NCIt: C35167 bone marrrow hypocellular WEB: http://www.drugs.com/condition/bone-marrow-depression-low-blood-counts.html CTCAE: E10022 a bone marrow disorder AE that has an outcome of an abnormal condition in which the bone marrow is unable to produce normal amounts of red blood cells, white blood cells and platelets WEB: http://en.diagnosispro.com/differential_diagnosis-for/bx-bone-marrow-biopsy-hypocellular/29777-154.html bone marrow disorder AE 10061729 a hematopoietic system AE that has an outcome of disease in the bone marrow, the spongy tissue inside of some bones that contain stem cells that can develop into red blood cells, white blood cells or platelets WEB: http://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html DJ, SS, YH bone marrow failure AE 10065553 DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23271412 a bone marrow disorder AE that has an outcome of an insufficient amount of red blood cells, white blood cells or platelets, associated with fanconii anemia, dyskeratosis congenita, and aplastic anemia bone marrow reticulin fibrosis AE 10069678 WEB: http://www.ncbi.nlm.nih.gov/pubmed/22246040 a bone marrow disorder AE that has an outcome of an excess formation of connective tissue in the bone marrow DJ, SS, YH bone marrow toxicity AE 10051779 SIDER: C0948168 WEB: http://www.ncbi.nlm.nih.gov/pubmed/12806941 DJ, SS, YH HPO: HP_0005561 a bone marrow disorder AE that has an outcome of the decrease in cells responsible for providing immunity, carrying oxygen and blood clotting bone marrow transplant AE 10061730 a bone marrow disorder AE that has an outcome of the replacement of damaged bone marrow with healthy bone marrow stem cells DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003009.htm bone swelling AE 10053631 a swelling AE that results in swelling around a bone DJ, SS, YH bowen's disease AE 10006059 DJ, SS, YH a skin adverse event that has an outcome of an early stage of squamous cell carcinoma WEB: http://medical-dictionary.thefreedictionary.com/bowen's+disease bradycardia neonatal AE 10056471 HPO: HP_0001662 a bradycardia AE that results in a decreased heart rate in a neonate SIDER: C1112488 WEB: http://www.ncbi.nlm.nih.gov/pubmed/10822186 DJ, SS, YH brain edema AE 10048962 DJ, SS, YH HPO: HP_0002181 an edema AE that has an outcome of edema or swelling of the extravascular compartment from uptake of water in the gray and white matter brain oedema AE WEB: http://medical-dictionary.thefreedictionary.com/cerebral+edema SIDER: C1527311 breast cancer AE 10006187 HPO: HP_0003002 SIDER: C0006142 DJ, SS, YH a tumor AE that has an outcome of cancer in the breast breast cancer metastatic AE 10055113 a breast cancer AE that has an outcome of cancerous cells spreading to the breast DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001911/ breast cancer stage iii AE 10006201 a breast cancer AE that has an outcome of breast cancer at the stage III level DJ, SS, YH breast infection AE 10006259 CTCAE: E11318 DJ, SS, YH HPO: HP_0002726 SIDER: C0392317 NCIt: C53662 an infection AE that results in the breast becoming infected breast pain AE 10006298 a pain AE that results in pain in the breast HPO: HP_0000769 NCIt:C78223 CTCAE:E13073 SIDER: C0024902 DJ, SS, YH, MW breast tenderness AE 10006313 HPO: HP_0100749 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21979747 DJ, SS, YH a reproductive system AE that has an outcome of pain or discomfort in the breast, may be caused by small benign tumors SIDER: C0262397 bronchopneumonia AE 10006469 DJ, SS, YH a pneumonia AE that has an outcome of acute inflammation of the walls of the smaller bronchial tubes, with irregular areas of consolidation due to spread of inflammation into peribronchiolar alveoli and the alveolar ducts of the lungs WEB: http://medical-dictionary.thefreedictionary.com/bronchopneumonia SIDER: C0006285 HPO: HP_0006538 bronchopulmonary aspergillosis AE 10006473 SIDER: C2350530 an immune system disorder AE that has an outcome of an exaggerated response of the immune system to the fungus Aspergillus HPO: HP_0002724 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/bronchopulmonary+aspergillosis bronchospasm AE 10006482 HPO: HP_0002099 SIDER: C0006266 WEB: http://medical-dictionary.thefreedictionary.com/bronchospasm NCIt:C34439 CTCAE:E13352 DJ, SS, YH, MW a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles burning sensation AE 10006784 a sensory capability AE that results in a feeling of burning DJ, SS, YH cachexia AE 10006895 DJ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Wasting+Syndrome Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23279159 SIDER: C0006625 a syndrom AE that has an outcome of a wasting syndrome characterized by weight loss, muscle atrophy, fatigue, and loss of appetite, often occurs with cancer. HPO: HP_0004326 cecitis AE 10006919 10045271 NCIt: C38043 a digestive system AE that has an outcome of inflammation of the caecum, part of the large intestine typhlitis AE caecitis AE WEB: http://medical-dictionary.thefreedictionary.com/caecitis DJ, SS, YH CTCAE: E11058 calcium deficiency AE 10006956 an endocrine system AE that has an outcome of deficiency of calcium in the body DJ, SS, YH capillary leak syndrome AE 10007196 Clarkson's Disease AE NCIt:C62578 CTCAE:E13766 DJ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmed/22873043 a cardiovascular disorder AE that has an outcome of self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the circulatory system to the interstitial space, resulting in hypotension, hemoconcentration, and hypoalbuminemia carcinoembryonic antigen increased AE 10007266 a cytogenetic investigation result abnormal AE that has an outcome of an increase in a type of protein typically associated with tumors and the developing fetus WEB: http://www.medicinenet.com/carcinoembryonic_antigen/article.htm DJ, SS, YH, EB carcinoid tumor AE 10007275 SIDER: C0007095 HPO: HP_0006723 carcinoid tumour AE a tumor AE that has an outcome of a carcinoid tumor that forms somewhere in the body WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307266 DJ, SS, YH hypochloremia AE 10020957 WEB: https://en.wikipedia.org/wiki/Hypochloremia HPO: HP_0003113 a blood chloride abnormal AE with an outcome of decrease in amount of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease UMLS CUI: C0085680 YH, MW cardiac failure AE 10007554 10019279 DJ, SS, YH heart failure NCIt: C50577 a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body WEB: http://medical-dictionary.thefreedictionary.com/cardiac+failure SIDER: C0018801 HPO: HP_0001635 CTCAE: E10124 cardiac failure congestive AE 10007559 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/congestive+heart+failure Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/21676684 congestive heart failure DJ, SS, YH HPO: HP_0001635 SIDER: C0018802 a cardiovascular disorder AE that results in an inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body cardiac pacemaker insertion 10007598 DJ, SS, YH a surgery that implants a cardiac pacemaker, a device that supplies electrical impulses to the heart to maintain the heartbeat at a regular rate WEB: http://www.mdguidelines.com/cardiac-pacemaker-insertion cardiac valve disease AE 10061406 WEB: http://medical-dictionary.thefreedictionary.com/valvular+heart+disease HPO: HP_0001654 a cardiac disorder AE that has an outcome of disease involving one or more of the valves of the heart DJ, SS, YH valvular disease AE SIDER: C0018824 cardiac ventricular disorder AE 10057455 DJ, SS, YH a cardiac disorder AE that has an outcome of a disorder involving the ventricle(s) in the heart WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/ventricular Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/15473469 cardiogenic shock AE 10007625 a hypotension AE that has an outcome of the inability of the heart to supply enough blood to the organs of the body because of heart damage WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001237/ DJ, SS, YH cardiomyopathy AE 10007636 WEB: https://en.wikipedia.org/wiki/Cardiomyopathy DJ, SS, YH a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure SIDER: C0878544 HPO: HP_0001638 WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy cardiotoxicity AE 10048610 WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy a cardiovascular disorder AE that has an outcome of heart electrophysiology dysfunction and/or muscle damage. Is not efficient at pumping/circulating blood DJ, SS, YH carotid arteriosclerosis AE 10067116 WEB: http://www.ncbi.nlm.nih.gov/pubmed/8198401 DJ, SS, YH a coronary artery disorder AE that results in lesion in carotid artery cataplexy AE 10007737 a musculoskeletal system AE that has an outcome of loss of muscle tone due to emotional responses like laughing and crying WEB: http://medical-dictionary.thefreedictionary.com/cataplexy SIDER: C0007384 HPO: HP_0002524 DJ, SS, YH cataract AE 10007739 SIDER: C0086543 WEB: http://medical-dictionary.thefreedictionary.com/cataract DJ, SS, YH NCIt: C26713 CTCAE: E10350 a eye disorder AE that results in cloudiness that develops in the eye HPO: HP_0000518 catheter related complication AE 10052253 DJ, SS, YH a sugery AE that has an adverse outcome related to the use of catheter, a thin tube inserted in the body WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23306712 catheter related infection AE 10007810 10056520 CTCAE: E11328 DJ, SS, YH NCIt: C78232 HPO: HP_0002719 an infection AE that has an outcome of an infection (e.g., bacterial colonisation) at the catheter site SIDER: C0860239 WEB: http://www.ncbi.nlm.nih.gov/pubmed/8825104 catheter site infection AE 10056520 DJ, SS, YH a bacterial infection AE that is located at the catheter site catheter site related reaction AE 10007811 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23074085 a sugery AE that has an adverse outcome at the site where a catheter was used DJ, SS, YH catheterization cardiac abnormal AE 10007816 DJ, SS, YH catheterisation cardiac abnormal AE a cardiac disorder AE that has an outcome of a problem after inserting a catheter into the heart WEB: http://medical-dictionary.thefreedictionary.com/cardiac+catheterization cauda equina syndrome AE 10007821 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23230403 DJ, SS, YH a behavior and neurological AE that has an outcome of an acute loss of function of the lumbar plexus central line infection AE 10054192 a bacterial infection AE that is located at the central-line catheter site WEB: http://www.ncbi.nlm.nih.gov/pubmed/7580945 SIDER: C1096243 DJ, SS, YH HPO: HP_0002719 central nervous system infection AE 10061036 HPO: HP_0005381 SIDER: C0007684 an infection AE that is located in the central nervous system DJ, SS, YH central nervous system lymphoma AE 10007953 DJ, SS, YH a tumor AE that has an outcome of lymphoma in the central nervous system cerebellar ataxia AE 10008025 DJ, SS, YH HPO: HP_0001251 an ataxia AE that is located in the cerebellum WEB: http://www.ncbi.nlm.nih.gov/pubmed/23283615 SIDER: C0007758 cerebellar syndrome AE 10008072 SIDER: C0007760 a brain disorder AE that has an outcome of an inherited brain disorder that affects muscle coordination, may involve the tendency for limb movements to overshoot or undershoot a target, tremors and impaired rhythm DJ, SS, YH HPO: HP_0001317 WEB: http://www.rightdiagnosis.com/medical/cerebellar_syndrome.htm cerebral hemorrhage AE 10008111 DJ, SS, YH a brain disorder AE with the outcome of hemorrhage or blood in the brain SIDER: C2937358 cerebral haemorrhage AE HPO: HP_0001342 cerebral ischemia AE 10008120 ischemic stroke AE cerebral ischaemia AE WEB: http://medical-dictionary.thefreedictionary.com/Cerebral+ischaemia SIDER: C0917798 a brain disorder AE that results in the sudden death of brain cells in a localized area due to inadequate blood flow HPO: HP_0002637 DJ, SS, YH cervicobrachial syndrome AE 10008334 DJ, SS, YH a nervous system AE that has an outcome of pain or another sensation in the patient's neck and shoulder region WEB: http://www.mdguidelines.com/cervicobrachial-syndrome/definition chapped lips AE 10049047 WEB: http://www.ncbi.nlm.nih.gov/pubmed/9433089 DJ, SS, YH a skin AE that has an outcome of dry lips caused by the evaporation of moisture. cheilitis AE 10008417 WEB: http://medical-dictionary.thefreedictionary.com/cheilitis an inflammation AE that occurs in the lip SIDER: C0007971 CTCAE: E10517 DJ, SS, YH HPO: HP_0100825 NCIt: C79545 chemical burn of skin AE 10057941 a skin AE that has an outcome of a burn due to chemicals on the skin DJ, SS, YH chest discomfort AE 10008469 WEB: http://medical-dictionary.thefreedictionary.com/chest+pain DJ, SS, YH SIDER: C0235710 a discomfort AE that has an outcome of pain in the chest HPO: HP_0001681 alcohol cardiomyopathy AE chloroma AE 10008583 DJ, SS, YH a progressive tumor AE that has an outcome of multiple, malignant, localized green masses of abnormal cells, usually myeloblasts, especially beneath the periosteum of the skull, spine and ribs WEB: http://medical-dictionary.thefreedictionary.com/chloroma cholangitis AE 10008604 a digestive system AE that has an outcome of infection in the common bile duct, usually by bacterial infection HPO: HP_0011040 SIDER: NA WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001335/ DJ, SS, YH cholestasis AE 10008635 DJ, SS, YH SIDER: C0008370 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001263/ a liver/biliary system AE that has an outcome of a condition in which the flow of bile from the liver is slowed or blocked HPO: HP_0001396 chondrocalcinosis pyrophosphate AE 10008690 DJ, SS, YH an adverse event that has an outcome of calcium crystals of calcium pyrophosphate dihydrate accumulated in the connective tissues of the patient WEB: http://medical-dictionary.thefreedictionary.com/chondrocalcinosis chromosome analysis abnormal AE 10008817 a cytogenetic investigation result abnormal AE that has an outcome of an abnormal chromosome pattern DJ, SS, YH, EB WEB: http://www.miscarriageclinic.co.uk/causes-and-treatments/chromosome-abnormality/ chemotherapy-induced peripheral neuropathy AE CIPN AG, YH a peripheral neuropathy AE which has an outcome of a chemotherapy-induced neuropathy that affects nerves of the peripheral nervous system (PNS) WEB: http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/chemotherapyeffects/peripheralneuropathy/peripheral-neuropathy-caused-by-chemotherapy-what-is-cipn chronic myeloid leukemia AE 10009013 WEB: http://medical-dictionary.thefreedictionary.com/chronic+myelogenous+leukemia chronic myeloid leukaemia AE a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by increased and unregulated growth of myeloid cells in the bone marrow HPO: HP_0005506 SIDER: C0023473 DJ, SS, YH chronic myeloid leukemia transformation AE 10068232 a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. May transform from chronic myeloid leukaemia to acute myeloid leukaemia chronic myeloid leukaemia transformation AE DJ, SS, YH WEB: http://www.jci.org/articles/view/41246 chronic obstructive pulmonary disease AE 10009033 a lung disorder AE that has an outcome of breathing difficulty with two main forms: chronic bronchitis and emphysema SIDER: C0024117 HPO: HP_0006510 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001153/ DJ, SS, YH chronic respiratory failure AE 10009126 a respiratory system AE that results in inadequate gas exchange by the respiratory system DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/respiratory+failure chronic sinusitis AE 10009137 WEB: http://www.mayoclinic.com/health/chronic-sinusitis/DS00232 DJ, SS, YH a respiratory system AE that has an outcome of inflammation in the cavities around the nasal passages chylothorax AE 10051228 a lung disorder AE that has an outcome of lymphatic fluid accumulating in the pleural cavity, the space between two pleura of the lungs CTCAE:E13358 DJ, SS, YH, MW NCIt:C79546 WEB: http://medical-dictionary.thefreedictionary.com/chylothorax circulatory collapse AE 10009192 WEB: http://medical-dictionary.thefreedictionary.com/circulatory+collapse a cardiovascular disorder AE that has an outcome of insufficient circulation without congestive heart failure DJ, SS, YH clostridial infection AE 10061043 HPO: HP_0004798 SIDER: C0009062 WEB: http://www.medicinenet.com/clostridium_difficile_colitis/page2.htm DJ, SS, YH a bacterial infection AE that has an outcome of invasion by anaerobic bacteria of the genus Clostridium, can cause tetanus and botulism clostridium difficile colitis AE 10009657 DJ, SS, YH HPO: HP_0002583 SIDER: C0238106 a digestive system AE that has an outcome of bacterial infection by clostridium difficile colitis, commonly results in diarrhea and colitis coagulation factor v level decreased AE 10009754 a coagulation factor v level abnormal AE that has an outcome of a decreased level of the factor V protein in the coagulation system of the body WEB: http://www.ncbi.nlm.nih.gov/pubmed/22781721 DJ, SS, YH, EB colitis AE 10009887 DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002112/ SIDER: C0009319 an inflammation AE that occurs at the large intestine NCIt: C26723 HPO: HP_0002583 CTCAE: E10521 collapse of lung AE 10009913 Pneumothorax a lung disorder AE that has an outcome of a collapsed lung, refering to the space between the wall of the chest cavity and the lung filling with air, causing all or a portion of the lung to collapse DJ, SS, YH colon cancer AE 10009944 SIDER: C0007102 a tumor AE that has an outcome of cancer that starts in the large intestine or the rectum DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/ HPO: HP_0003003 colon cancer metastatic AE 10055114 a colon AE that has an outcome of cancerous cells spreading to the colon DJ, SS, YH WEB: http://www.cancer.gov/cancertopics/factsheet/Sites-Types/metastatic colon cancer stage iv AE 10009956 DJ, SS, YH a colon cancer AE that has an outcome of colon cancer at stage IV colorectal cancer AE 10061451 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/ a digestive system AE that has an outcome of cancer that starts in the large intestine or rectum. DJ, SS, YH HPO: HP_0003003 SIDER: C1527249 colorectal cancer metastatic AE 10052358 WEB: http://www.ncbi.nlm.nih.gov/pubmed/22642873 DJ, SS, YH a digestive system AE that has an outcome of cancer in the large intestine and the rectum. When metastatic, the cancer has already spead to distant sites and is considered stage IV. HPO: HP_0003003 SIDER: C0948380 computerized tomography result abnormal AE 10010235 DJ, SS, YH, EB an imaging investigation result abnormal AE that has an abnormal result of an imaging method in which a cross-sectional image of the structures in a body plane is reconstructed by a computer program from the x-ray absorption of beams projected through the body in the image plane WEB: http://medical-dictionary.thefreedictionary.com/computed+tomography computerised tomogram abnormal AE WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/computerized+tomography , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23271098 concomitant disease progression AE 10048659 DJ, SS, YH an adverse event that has an outcome of progression of underlying conditions that may affect drug distribution or metabolism WEB: http://medical-dictionary.thefreedictionary.com/Concomitant+disease condition aggravated AE 10010264 an adverse event that has an outcome of condition that worsens DJ, SS, YH congenital cardiovascular anomaly AE 10061054 WEB: http://www.thefreedictionary.com/congenital+heart+defect DJ, SS, YH a congenital abnormality AE that has an outcome of an abnormality in heart which is present at birth SIDER: C0243050 HPO: HP_0001626 congestive cardiomyopathy AE 10056370 a cardiomyopathy AE that is characterized by the walls of the heart chambers stretching to hold a greater volume of blood than normal HPO: HP_0001635 SIDER: C0007193 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/congestive+cardiomyopathy conjunctival disorder AE 10061446 SIDER: C0009759 WEB: http://medical-dictionary.thefreedictionary.com/conjunctiva DJ, SS, YH an eye disorder AE that has an outcome of a problem involving the insides of the patient's eyelids HPO: HP_0000502 conjunctival hemorrhage AE 10010719 SIDER: C0009760 a hemorrhage AE that has an outcome of a bright hemorrhagic patch on the bulbar conjunctiva caused by rupture and bleeding of a superficial small capillary due to increased pressure conjunctival haemorrhage AE DJ, SS, YH HPO: HP_0007902 connective tissue disorder AE 10061087 DJ, SS, YH HPO: HP_0003549 an adverse event that has an outcome of disease in the biological tissue that supports, binds together and protects organs SIDER: C0009782 WEB: http://medical-dictionary.thefreedictionary.com/connective+tissue+disease contact lens intolerance AE 10010804 an eye disorder AE that has a result of the inability to use contact lenses DJ, SS, YH coombs' test positive AE 10061090 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/test a hematology investigation result abnormal AE that has an outcome of a positive coombs test, which is a blood test that identifies the causes of anemia WEB: http://medical-dictionary.thefreedictionary.com/Coombs'+Tests coordination abnormal AE 10010947 SIDER: C0520966 HPO: HP_0011443 a behavior and neurological AE that results in a loss of coordination DJ, SS, YH coronary angioplasty AE 10050329 DJ, SS, YH a cardiac disorder AE that has an outcome of treatment involving the stenotic coronary arteries in the heart WEB: http://medical-dictionary.thefreedictionary.com/coronary+angioplasty coronary artery embolism AE 10011084 a coronary artery disorder AE that has an outcome of an blockage in the coronary artery DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22953315 coronary artery insufficiency AE 10052895 a coronary artery disorder AE that has an outcome of an insufficient amount of blood circulates through the coronary arteries SIDER: C0542052 DJ, SS, YH HPO: HP_0001677 WEB: http://medical-dictionary.thefreedictionary.com/coronary+insufficiency craniopharyngioma AE 10011318 WEB: http://medical-dictionary.thefreedictionary.com/craniopharyngioma DJ, SS, YH a tumor AE that has an outcome of a brain tumor derived from the embryonic tissue of the pituitary gland c-reactive protein level increased AE 10006825 a c-reactive protein level abnormal AE that has an outcome of an increased amount of CRP, a protein that measure general levels of inflammation in the body DJ, SS, YH, EB moved "c-reactive protein increased AE" from "cardiac AE" to "lab test abnormal AE" EB WEB: http://www.webmd.com/a-to-z-guides/c-reactive-protein-crp viral cardiomyopathy AE csf pressure increased AE 10011570 WEB: http://medical-dictionary.thefreedictionary.com/intracranial+pressure a nervous system AE that has an outcome of increased pressure in the skull DJ, SS, YH culture urine positive AE 10011640 WEB: http://labtestsonline.org/understanding/analytes/urine-culture/tab/test DJ, SS, YH, EB a urine analysis result abnormal AE that has an outcome of high bacterial colonization counts in the urine cutaneous vasculitis AE 10011686 WEB: http://dermnetnz.org/vascular/vasculitis.html HPO: HP_0200029 皮肤血管炎 an inflammation AE that has an outcome of inflamed blood vessels in the skin DJ, SS, YH SIDER: C0262988 cystitis hemorrhagic AE 10011793 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+cystitis a urinary system AE that has an outcome of cystitis with severe hemorrhage, a dose-limiting toxic condition with administration of ifosfamide and cyclophosphamide or a complication of bone marrow transplantation cystitis haemorrhagic AE cytogenetic abnormality AE 10067477 DJ, SS, YH a genetic disorder AE that has an outcome of an atypical number of chromosomes or a structural abnormality in one or more chromosomes cytokine release syndrome AE 10052015 WEB: http://encyclopedia.thefreedictionary.com/cytokine+release+syndrome DJ, SS, YH NCIt: C78251 an inflammation AE that has an outcome of release of cytokines by T cells that causes inflammation CTCAE: E11264 cytolytic hepatitis AE 10050904 WEB: http://www.thirdage.com/hc/c/q/hepatitis/1550008/what-is-cytolytic-hepatitis SIDER: C0919823 DJ, SS, YH a liver/biliary system AE that has an outcome of liver cells carrying excess water, causing inflammation along with hepatitis HPO: HP_0004787 cytomegalovirus colitis AE 10048983 an inflammation AE that results in the inflammation of the colon WEB: http://www.ncbi.nlm.nih.gov/pubmed/22874621 DJ, SS, YH cytomegalovirus infection AE 10011831 DJ, SS, YH SIDER: C0010823 HPO: HP_0004429 WEB: http://www.nlm.nih.gov/medlineplus/cytomegalovirusinfections.html a viral infection AE that is caused by cytomegalovirus dandruff AE 10011859 WEB: http://medical-dictionary.thefreedictionary.com/dandruff HPO: HP_0001051 a skin AE that has an outcome of shedding of the dead skin cells from the scalp DJ, SS, YH SIDER: C0221244 debridement 10057612 10067806 a surgery that performs a medical removal of dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue DJ, SS, YH, SJ WEB: http://medical-dictionary.thefreedictionary.com/Debridement WEB: http://www.surgeryencyclopedia.com/Ce-Fi/Debridement.html decubitus ulcer AE 10011985 HPO: HP_0200042 a skin ulcer AE that has an outcome of localized injuries to the skin and/or underlying tissue usually over a bony prominence as a result of pressure WEB: http://medical-dictionary.thefreedictionary.com/pressure+ulcer SIDER: C0011127 DJ, SS, YH deep vein thrombosis AE 10051055 DJ, SS, YH a venous thrombosis that is characterized by a blood clot that forms in a vein deep in the body. Blood clots occur when blood thickens and clumps together. Most deep vein blood clots occur in the lower leg or thigh. They also can occur in other parts of the body. Moved from Cardiac AE to thombosis AE by LB SIDER: C0149871 HPO: HP_0004850 DVT WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/dvt/ delirium AE 10012218 NCIt:C2981 a psychiatric disorder AE that results in a decline in level of cognitive function CTCAE:E12898 DJ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/delirium dental caries AE 10012318 DJ, SS, YH a tooth disorder AE that has an outcome of bacterial infection that causes demineralization and destruction of the hard tissues, resulting in dental cavities WEB: http://medical-dictionary.thefreedictionary.com/dental+caries SIDER: C0011334 NCIt: C52593 CTCAE: E10568 HPO: HP_0000670 depressed level of consciousness AE 10012373 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23167919 NCIt:C78253 CTCAE:E12625 HPO: HP_0004372 SIDER: C0549249 DJ, SS, YH, MW a sensory capability AE that results in a lower level of arousal than normal dermatitis acneiform AE 10012432 a dermatitis ae that is characterized by the eruption of papules and pustules, typically on the face, scalp, upper chest and back. DJ, SS, YH SIDER: C0234894 WEB: https://www.medify.com/conditions/acneiform-dermatitis HPO: HP_0001051 dermatitis exfoliative AE 10012455 HPO: HP_0011123 SIDER: C0011606 DJ, SS, YH a dermatitis ae that is characterized by an inflammatory skin disease with erythmea and scaling, that has an outcome of widespread scaling of the skin, often with itching, skin redness and hair loss WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001610.htm dermatomyositis AE 10012503 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001842/ DJ, SS, YH a muscle AE that has an outcome of muscle weakness, inflammation, skin rash and difficulty swallowing developmental coordination disorder AE 10012557 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001533.htm a motor neuropathy AE that has an outcome of poor coordination DJ, SS, YH device dislocation AE 10064684 an injury and procedural complication AE that results in the dislocation of a device DJ, SS, YH device expulsion AE 10012578 DJ, SS, YH an injury and procedural complication AE that results in the expulsion (vomiting) of medical device from body device related infection AE 10064687 NCIt: C79705 SIDER: C1619702 CTCAE: E11356 HPO: HP_0002719 an injury and procedural complication AE that results in an infection related to medical device DJ, SS, YH diabetic hyperglycemic coma AE 10012668 a coma AE which is induced by the condition that the patient has extremely high levels of sugar in the blood without ketones DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000304.htm diabetic hyperglycaemic coma AE diaphragmatic hernia AE 10012713 a respiratory system AE that has an outcome of an abnormal hole in the diaphragm WEB: http://www.ncbi.nlm.nih.gov/pubmed/23288807 SIDER: C0019284 DJ, SS, YH HPO: HP_0000776 diaphragmatic paralysis AE 10012725 DJ, SS, YH a paralysis AE that has an outcome of a paralyzed diaphragm WEB: http://www.ncbi.nlm.nih.gov/pubmed/19452391 diarrhea hemorrhagic AE 10012741 a diarrhea AE that has an outcome of rectal bleeding and bloody diarrhea diarrhoea haemorrhagic AE HPO: HP_0002255 DJ, SS, YH SIDER: C0151594 WEB: http://www.ncbi.nlm.nih.gov/pubmed/19292138 diarrhea infectious AE 10012742 DJ, SS, YH a diarrhea AE that has an outcome of diarrhea is caused by infection diarrhoea infectious AE diastolic dysfunction AE 10052337 WEB: http://encyclopedia.thefreedictionary.com/diastolic+dysfunction a cardiac disorder AE with an outcome of decline in performance of one or both ventricles of the heart during the time phase of diastole, when heart filling with incoming blood DJ, SS, YH dilatation ventricular AE 10013012 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721391/ a cardiac ventricular disorder AE that has an outcome of enlargement of a heart chamber that pumps blood away from the heart DJ, SS, YH disease progression AE 10061818 an adverse event with an outcome of worsening of the disease HPO: HP_0004738 DJ, SS, YH SIDER: C0242656 dislocation of vertebra AE 10013183 a bone disorder AE that has an outcome of dislocation of vertebra DJ, SS, YH disorientation AE 10013395 a sensory capability AE that results in the senses of time, direction, and recognition of people and places becoming difficult to distinguish WEB: http://medical-dictionary.thefreedictionary.com/disorientation DJ, SS, YH SIDER: C0233407 HPO: HP_0001289 disseminated intravascular coagulation AE 10013442 NCIt: C2992 HPO: HP_0005521 CTCAE: E10028 a hematopoietic system AE with an outcome of a serious disorder in which proteins that control blood clotting become abnormally active WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000573.htm DJ, SS, YH SIDER: C0012739 disturbance in attention AE 10013496 DJ, SS, YH HPO: HP_0007018 SIDER: C0233414 a behavior and neurological AE that results in a loss of attention diverticular perforation AE 10061820 a digestive system AE with an outcome of perforation of small sacs or pockets in the wall of the colon DJ, SS, YH WEB: http://www.webmd.com/digestive-disorders/diverticular-disease diverticulitis AE 10013538 DJ, SS, YH a digestive system AE that has an outcome of infection and inflammation in the small, bulging sacs or pouches of the inner lining of the intestine SIDER: C0012813 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001303/ HPO: HP_0002253 diverticulitis intestinal hemorrhagic AE 10013541 diverticulitis intestinal haemorrhagic AE DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780263/ a hemorrhage AE that has an outcome of bleeding in the intestine due to diverticulitis drug clearance decreased AE 10049463 DJ, SS, YH an adverse event that has an outcome of a decreased amount of the drug excreted by the body WEB: http://medical-dictionary.thefreedictionary.com/drug+clearance drug dependence AE 10013663 DJ, SS, YH an adverse drug event that results in the development of a dependence on the drug SIDER: C1510472 HPO: HP_0000722 drug eruption AE 10013687 a skin AE that has an outcome of a range of adverse drugs reactions of the skin, most commonly rashes resembling measles WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption DJ, SS, YH drug hypersensitivity AE 10013700 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23192511 DJ, SS, YH a hypersensitivity AE that has an outcome of allergic reactions to certain drugs HPO: HP_0100326 SIDER: C0013182 drug intolerance AE 10061822 a drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/drug+intolerance drug withdrawal headache AE 10013753 DJ, SS, YH a headache AE that has an outcome of headaches due to drug withdrawal drug withdrawal syndrome AE 10013754 WEB: http://medical-dictionary.thefreedictionary.com/withdrawal an adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug DJ, SS, YH dry skin AE 10013786 HPO: HP_0000958 DJ, SS, YH, MW NCIt:C74592 a skin AE that is characterized by epidermis that lacks moisture, has an outcome of fine lines, scaling and itching CTCAE:E13623 SIDER: C0151908 WEB: http://medical-dictionary.thefreedictionary.com/dry+skin duodenal ulcer AE 10013836 HPO: HP_0002588 a duodenum AE that has an outcome of a peptic ulcer, or a defect in the lining of the stomach or the first part of the small intestine, located in the duodenum SIDER: C0013295 CTCAE: E10611 DJ, SS, YH NCIt: C26755 peptic ulcer AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ duodenal ulcer hemorrhage AE 10013839 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ HPO: HP_0002588 a duodenal ulcer AE with an outcome of bleeding in an ulcer, or a defect, in the lining of the stomach or first part of the small intestine called the duodenum duodenal ulcer haemorrhage AE DJ, SS, YH SIDER: C0151966 duodenal ulcer perforation AE 10013849 a duodenal ulcer AE that has an outcome of perforation, or complete penetration, of an ulcer located in an area of the small intestine called the duodenum WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ SIDER: C0740401 HPO: HP_0002588 DJ, SS, YH dysarthria AE 10013887 DJ, SS, YH, MW SIDER: C0013362 a speech disorder that results in a motor speech disorder CTCAE:E12635 WEB: http://medical-dictionary.thefreedictionary.com/dysarthria NCIt:C79549 HPO: HP_0001260 dyslexia AE 10013932 SIDER: C0476254 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/dyslexia HPO: HP_0010522 a behavioral and neurological AE that results in difficulty reading (mixing up letters) dysphonia AE 10013952 a speech disorder AE that results in disorders of voice SIDER: C1527344 WEB: http://medical-dictionary.thefreedictionary.com/dysphonia HPO: HP_0001618 DJ, SS, YH dyspnoea exertional AE 10013971 a dyspnoea AE that has an outcome of shortness of breath during exercise, produces a sensation of not being able to get enough air SIDER: C0231807 DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22760109 HPO: HP_0002875 dysuria AE 10013990 WEB: http://medical-dictionary.thefreedictionary.com/dysuria 排尿困难 urination disorders AE SIDER: C0013428 HPO: HP_0100518 Dysuria AE is an urinary system AE that results in painful urination JX, DJ, SS, YH eating disorder AE 10014062 WEB: http://medical-dictionary.thefreedictionary.com/eating+disorder DJ, SS, YH a gustatory system AE which has an outcome of abrnormal or disturbed eating habits ectopic pregnancy with intrauterine device AE 10067037 a female reproductive system AE that results in an ectopic pregnancy that occurs along with the use of an IUD DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/ectopic+pregnancy eczema AE 10014184 HPO: HP_0000964 DJ, SS, YH a skin AE that has an outcome of a long term skin disorder that involves scaly and itchy rashes WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001856/ SIDER: C0013595 effusion AE 10063045 an abnormal fluid regulation AE that has an outcome of escape of a fluid into a part WEB: http://medical-dictionary.thefreedictionary.com/effusion DJ, SS, YH ejaculation delayed AE 10014325 SIDER: NA HPO: HP_0000022 a male reproductive system AE that has an outcome of a delay of ejaculation DJ, SS, YH ejection fraction decreased AE 10050528 a left ventricular dysfunction AE that has an outcome of decreased percentage of blood leaving the heart each time it contracts DJ, SS, YH NCIt: C83492 CTCAE: E12142 WEB: http://www.mayoclinic.com/health/ejection-fraction/AN00360 electrocardiogram result abnormal AE 10014363 a cardiac function test abnormal AE that has an outcome of abnormal electrical activity in the heart WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003868.htm DJ, SS, YH, EB electrocardiogram qrs complex abnormal AE 10014378 DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23238367 an electrocardiogram result abnormal AE that has an outcome of an abnormal depolarization of the right and left ventricles of the heart that is detected on an electrocardiogram test electrocardiogram qt prolonged AE 10014387 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23275261 SIDER: C0151878 an electrocardiogram result abnormal AE that has an outcome of a prolonged time between the start of the Q wave and the end of the T wave in the heart's electrical cycle; a biomarker for ventricular tachyarrhythmias HPO: HP_0001657 DJ, SS, YH, EB electrocardiogram t wave peaked AE 10014396 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301064; http://www.medaphile.com/medical-dictionary/t-wave-peaked DJ, SS, YH, EB an electrocardiogram result abnormal AE in which the T wave appears increased in amplitude and cresting at a point electrolyte imbalance AE 10014418 HPO: HP_0003111 a homeostasis AE that has an outcome of abnormalities in electrolytes (sodium, potassium, calcium) WEB: http://medical-dictionary.thefreedictionary.com/electrolyte+imbalance SIDER: C0342579 DJ, SS, YH emotional disorder AE 10014551 DJ, SS, YH a psychiatric disorder AE that results in an abnormal expression of emotions SIDER: C0233459 WEB: http://medical-dictionary.thefreedictionary.com/emotional+disorder HPO: HP_0100851 endocarditis AE 10014665 HPO: HP_0100584 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002088/ SIDER: C0014118 DJ, SS, YH an inflammation AE that occurs in the inside lining of the heart chambers and heart valves enteritis AE 10014866 DJ, SS, YH a digestive system AE with an outcome of inflammation in the intestine, especially the small intestine HPO: HP_0004387 WEB: http://medical-dictionary.thefreedictionary.com/enteritis SIDER: C0014335 enterocolitis AE 10014893 HPO: HP_0004387 SIDER: C0014356 WEB: http://medical-dictionary.thefreedictionary.com/enterocolitis CTCAE: E10627 DJ, SS, YH a digestive system AE that has an outcome of disease in the digestive tract caused by infection NCIt: C79573 enterocolitis infectious AE 10058838 WEB: http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0792-2..50022-5--cesec139&isbn=978-1-4377-0792-2&type=bookPage&from=content&uniqId=376758653-2 an digestive system AE that has an outcome of an infection by enteric viruses or enterotoxigenic bacterias, usually in the intestines, that presents with diarrhea, abdominal pain, perianal discomfort, incontinence and hemorrhage. DJ, SS, YH eosinophil count increased AE 10014945 DJ, SS, YH an eosinophil count abnormal AE that has an outcome of an increased amount of eosinophils, a type of white blood cell that becomes active with allergic diseases and infections WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003649.htm SIDER: C2240374 HPO: HP_0001880 eosinophilia AE 10014950 WEB: http://www.mayoclinic.com/health/eosinophilia/MY00399 DJ, SS, YH a hematopoietic system AE that has an outcome of higher than normal levels of eosinophils, a type of white blood cell HPO: HP_0001880 SIDER: C0014457 erectile dysfunction AE 10061461 astyphia AE WEB: http://en.wikipedia.org/wiki/Erectile_dysfunction SIDER: C0242350 CTCAE:E13088 DJ, SS, JX, LW, YH, MW HPO: HP_0008652 a male reproductive system AE that results in the inability to develop/maintain an erection of penis impotence AE 阳痿/勃起功能障碍 NCIt:C3133 erysipelas AE 10015145 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001643/ HPO: HP_0001055 SIDER: C0014733 DJ, SS, YH a skin AE that has an outcome of an infection caused by a Streptococcus bacteria that causes blisters, fever and skin lesion and sores erythrodermic psoriasis AE 10015278 a psoriasis AE that has an outcome of psoriasis that affects all sites on the body DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/psoriatic+erythroderma escherichia infection AE 10061126 a bacterial infection AE with an outcome of invasion by Escherichia coli bacteria, commonly found in the lower intestine and can cause serious food poisoning, but can also be found in various parts of body WEB: http://medical-dictionary.thefreedictionary.com/escherichia+coli DJ, SS, YH escherichia test positive AE 10070090 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/Escherichia a microbiology and serology investigation result abnormal AE that has an outcome of a positive escherichia test escherichia urinary tract infection AE 10052238 WEB: http://www.medicinenet.com/urine_infection/article.htm DJ, SS, YH an urinary tract infection AE that has an outcome of infection caused by E. coli bacteria excessive granulation tissue AE 10063560 DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19594571 a connective tissue AE that has an outcome of excess perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds. exfoliative rash AE 10064579 WEB: http://medical-dictionary.thefreedictionary.com/exfoliative+dermatitis DJ, SS, YH a rash AE that has an outcome of erythema, desquamation, scaling, itching of the skin and loss of hair exomphalos AE 10015677 a congenital abnormality that results in a weakness of the baby's abdominal wall where the umbilical cord joins it. This weakness allows the abdominal contents to protrude outside the abdominal cavity SIDER: C1306503 WEB: http://medical-dictionary.thefreedictionary.com/exomphalos DJ, SS, YH HPO: HP_0001539 exposure to contaminated device AE 10068515 an injury and procedural complication AE that results in the patient being exposed to a contaminated device DJ, SS, YH exposure to toxic agent AE 10053487 DJ, SS, YH a procedural complication AE that results in the patient being exposed to a toxic agent extradural abscess AE 10061846 an abscess AE that results in a collection of pus between a person's skull and dura DJ, SS, YH WEB: http://www.meb.uni-bonn.de/dtc/primsurg/docbook/html/x1217.html extraocular muscle paresis AE 10015829 a paresis AE that results in a partial loss of voluntary movement in their extraocular muscles DJ, SS, YH NCIt: C78286 CTCAE: E10367 WEB: http://www.ncbi.nlm.nih.gov/pubmed/22824489 coagulopathy AE 10009802 bleeding disorder coagulopathy AE results in the impairment of blood to clot causing ecessive or prolonged bleeding. SJ, YH clotting disorder WEB: http://en.wikipedia.org/wiki/Coagulopathy eye hemorrhage AE 10015926 DJ, SS, YH a hemorrhage AE that has an outcome of hemorrhage occuring in the blood vessels in the eye eye haemorrhage AE SIDER: C0015402 subconjunctival haemorrhage AE HPO: HP_0011885 WEB: http://www.webmd.com/eye-health/bleeding-in-the-eye eye swelling AE 10015967 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21115963 DJ, SS, YH a eye disorder AE that has an outcome of swelling in the tissues around the eyes, called the orbits, caused by fluid buildup perioribtal puffiness AE eyelid edema AE 10015993 SIDER: C0162285 an eye edema AE that has an outcome of swelling in either or both the lower and upper eyelids, due to fluid buildup or inflammation in the delicate tissues surrounding the eye. WEB: http://www.localhealth.com/article/eyelid-swelling eyelid oedema AE DJ, SS, YH HPO: HP_0100539 failure to thrive AE 10016165 SIDER: C0015544 HPO: HP_0001531 DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000991.htm A pregnancy, neonatal and perinatal AE that displays the result of failure to thrive (FTT), which refers to a baby or child that is not developing as well as desired. WEB: http://www.stanfordchildrens.org/en/topic/default?id=failure-to-thrive-90-P02297 fall AE 10016173 CTCAE: E11687 NCIt: C50558 HPO: HP_0002359 a behavior and neurological AE that has an outcome of patient falling DJ, SS, YH SIDER: C0085639 fear of needles AE 10068298 a behavior and neurological AE that results in the extreme fear of needles DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/23225704 febrile bone marrow aplasia AE 10053213 WEB: http://medical-dictionary.thefreedictionary.com/Bone+marrow+aplasia a hematopoietic system AE that has an outcome of inadequate blood cell formation by bone marrow accompanied by a fever DJ, SS, YH febrile infection AE 10051998 DJ, SS, YH a fever AE that has an outcome of an infection along/because of a fever WEB: http://medical-dictionary.thefreedictionary.com/febrile febrile neutropenia AE 10016288 CTCAE: E10033 a neutropenia AE, generally a complication of chemotherapy, that has an outcome of an abnormally low neutrophil granulocyte count, accompanied by fever NCIt: C35665 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23303687 neutropenic sepsis AE SIDER: C0746883 DJ, SS, YH HPO: HP_0001875 feeding tube complication AE 10056661 WEB: http://www.thirdage.com/hc/p/197842/what-is-tube-feeding enteral feeding AE DJ, SS, YH an injury and procedural complication AE that has an outcome of an complication due to the use of enteral feeding tube feeling abnormal AE 10016322 DJ, SS, YH SIDER: C1443060 HPO: HP_0010870 a sensory capabilty AE that results in the patient feeling different than normal after a medical intervention such as taking drug feeling hot AE 10016334 DJ, SS, YH Feeling hot AE is a feeling abnormal AE that a patient feels hot. hypoesthesia oral AE 10057371 WEB: http://en.wikipedia.org/wiki/Hypoesthesia SS, YH HPO: HP_0010830 a hypoaesthesia AE that has an outcome of a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli in the oral area SIDER: C0521592 hypoaesthesia oral AE fistula discharge AE 10067143 a fistula AE that has an outcome of discharge that occurs as the result of the connection between two body cavities WEB: http://www.ncbi.nlm.nih.gov/pubmed?term=fistula%20discharge%20%5BTI%5D DJ, SS, YH fluid intake reduced AE 10056291 an abnormal fluid regulation AE with an outcome of decrease in ingestion of water or other fluids DJ, SS, YH fluid overload AE 10016803 WEB: http://www.ncbi.nlm.nih.gov/pubmed/22827112 DJ, SS, YH a hematopoietic system AE that has an outcome of too much fluid in the blood, can occur due to increase in total body sodium focal nodular hyperplasia AE 10052285 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/focal+nodular+hyperplasia a hyperplasia AE that has an outcome of a benign tumor in the liver fetal heart rate deceleration AE 10058322 foetal heart rate deceleration AE a congenital abnormality disorder AE that has an outcome of a decreased heart rate in a fetus DJ, SS, YH folliculitis AE 10016936 DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001826/ a skin AE with the outcome disease involving of one more more hair follicles, commonly displays rash, itching and pustules near the hair follicles forced expiratory volume decreased AE 10016987 CTCAE: E12156 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/forced+expiratory+volume NCIt: C50524 a respiratory system AE that has an outcome of a decreased volume of air expired from the lungs forearm fracture AE 10016997 a bone disorder AE that has an outcome of fracture located in the arm DJ, SS, YH fracture AE 10017076 DJ, SS, YH a bone disorder AE that has an outcome of complete or incomplete break in a bone resulting from the application of excessive force NCIt: C3046 WEB: http://medical-dictionary.thefreedictionary.com/Fractures CTCAE: E11703 full blood count decreased AE 10017413 a full blood count abnormal AE that has an outcome of a decrease in full blood cell count DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/full+blood+count fungal esophagitis AE 10049656 fungal oesophagitis AE DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/ a digestive system AE that has an outcome of inflammation in the esophagus due to fungus gallbladder enlargement AE 10062693 a digestive system AE that has an outcome of an abnormal enlargement in the size of the gallbladder DJ, SS, YH gallbladder perforation AE 10017639 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/gallbladder+perforation NCIt: C78309 a digestive system AE that has an outcome of an abnormal hole in the patient's gallbladder CTCAE: E11208 gallbladder polyp AE 10049704 a digestive system AE that has an outcome of an abnormal growth (accumulation of mucous membrane tissue) in the gallbladder WEB: http://www.ncbi.nlm.nih.gov/pubmed/19556839 DJ, SS, YH gallop rhythm present AE 10017648 WEB: http://circ.ahajournals.org/content/20/6/1053.full.pdf DJ, SS, YH an arrhythmia AE that results in an abnormal heart sound gamma-glutamyltransferase level abnormal AE 10017688 a liver related investigation result abnormal AE that has an outcome of an abnormal level of gamma-glutamyltransferase (GGT); GGT is involved in the transfer of amino acids across the cellular membrane DJ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003458.htm gamma-glutamyltransferase level increased AE 10017693 10056910 CTCAE: E12161 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23258530 DJ, SS, YH, EB GGT increased a gamma-glutamyltransferase level abnormal AE that has an outcome of an increase in gamma-glutamyltransferase enzyme presence in the liver NCIt: C26943 gastric cancer AE 10017758 DJ, SS, YH SIDER: C0024623 a gastric disorder AE that has an outcome of cancer that starts in the stomach HPO: HP_0006753 gastric neoplasm AE 10061968 WEB: http://medical-dictionary.thefreedictionary.com/stomach+cancer a tumor AE that has an outcome of cancer in the stomach DJ, SS, YH gastric ulcer AE 10017822 DJ, SS, YH CTCAE: E10727 HPO: HP_0002592 a gastric disorder AE that has an outcome of a defect in the lining of the stomach 胃溃疡 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/ SIDER: C0038358 NCIt: C3388 gastritis AE 10017853 SIDER: C0017152 NCIt: C26780 CTCAE: E10733 a gastric disorder AE that has an outcome of inflammation in the lining of the stomach DJ, SS, YH HPO: HP_0005263 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002135/ gastritis atrophic AE 10017860 DJ, SS, YH a gastritis AE that has an outcome of inflammation in the stomach mucosa WEB: http://www.ncbi.nlm.nih.gov/pubmed/2789800 gastritis erosive AE 10017865 DJ, SS, YH HPO: HP_0005263 SIDER: C2243088 a gastritis AE that has an outcome of gastric mucosal erosion caused by damage to mucosal defences WEB: http://medical-dictionary.thefreedictionary.com/gastritis ischemic colitis AE 10009896 SJ, YH ischemic colitis AE is a gastrointestinal disorder AE that results in injury and inflammation of the large intestine due to inadequate blood supply. WEB: http://en.wikipedia.org/wiki/Ischemic_colitis gastroenteritis norovirus AE 10068189 a gastroenteritis AE that has an outcome of disease caused by the norovirus WEB: http://www.cdc.gov/ncidod/dvrd/revb/gastro/faq.htm DJ, SS, YH gastroenteritis radiation AE 10017912 DJ, SS, YH a gastroenteritis AE that has an outcome of disease due to radiation gastroesophageal reflux disease AE 10017885 10066874 NCIt: C26781 esophageal reflux AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301861 GERD AE CTCAE: E10739 a digestive system AE that results in mucosal damage caused by acid from stomach coming up to the esophagus gastrooesophageal reflux disease AE DJ, SS, YH gastrointestinal infection AE 10017964 HPO: HP_0004798 DJ, SS, YH a gastrointestinal disorder AE with an outcome of infection in the digestive tract caused by bacteria, viruses or parasites WEB: http://medical-dictionary.thefreedictionary.com/Gastrointestinal+infection SIDER: C1264613 gastrointestinal injury AE 10061172 DJ, SS, YH a gastrointestinal disoder AE that has an outcome of an injury in the gastrointestinal area WEB: http://www.ncbi.nlm.nih.gov/pubmed/23207874 gastrointestinal necrosis AE 10017982 DJ, SS, YH a gastrointestinal disoder AE that has an outcome of premature death in cells of living tissue in the stomach and intestines WEB: http://medical-dictionary.thefreedictionary.com/necrosis bupropion-induced adverse event YH an adverse event induced by administration of a bupropion drug gastrointestinal perforation AE 10018001 HPO: HP_0011024 SIDER: C0151664 a gastrointestinal disorder AE that results in a hole in the wall of the esophagus, stomch, small intestine, large bowel, rectum or gallbladder DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/ gastrointestinal stromal tumor AE 10051066 SIDER: C0238198 DJ, SS, YH gastrointestinal stromal tumour AE HPO: HP_0007378 WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor a tumor AE that has an outcome of a tumor in the gastrointestinal tract, thought to grow from specialized cells found in the tract called interstitial cells of Cajal gastrointestinal toxicity AE 10059024 a gastrointestinal disorder AE that has an outcome of poison affecting the stomach and/or intestinal tracts, often accompanied by abdominal pain, diarrhea and vomiting WEB: http://www.theodora.com/drugs/valcyte_tablets_roche_laboratories.html HPO: HP_0011024 DJ, SS, YH SIDER: C1142499 gene mutation identification test positive AE 10063478 DJ, SS, YH, EB WEB: https://www.duchenneconnect.org/index.php?option=com_content&view=article&id=346&Itemid=392&lang=en a cytogenetic investigation result abnormal AE that has an outcome of a positive test for gene mutation, deletions and duplications that could indicate large disease risk general physical health deterioration AE 10049438 a systematic adverse event that has an outcome of worsening of physical health DJ, SS, YH generalized edema AE 10018092 WEB: http://www.ncbi.nlm.nih.gov/pubmed/16491771 generalised oedema AE an edema AE that has an outcome of edema where causes of edema are generalized to the whole body, can cause edema in multiple organs and peripherally DJ, SS, YH SIDER: C0151603 HPO: HP_0007430 genital ulceration AE 10018180 a skin ulcer AE that results in an ulcer in the genital area usually resulting from an STD HPO: HP_0003249 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23064541 SIDER: C0151281 DJ, SS, YH gingival abscess AE 10052359 DJ, SS, YH WEB: http://www.mdguidelines.com/gingival-abscess an abscess AE that has an outcome of a gum-line of the teeth due to pus-filled sacs gingival swelling AE 10018291 DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003066.htm a digestive system AE that has an outcome of abnormally enlarged, bulging or protruding gums glomerular filtration rate decreased AE 10018358 SIDER: C0853068 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007305.htm a kidney disorder AE that has an outcome of a decreased rate per minute at which the blood passes through the glomeruli or the filters in the kidneys DJ, SS, YH HPO: HP_0000083 glossodynia AE 10018388 WEB: http://medical-dictionary.thefreedictionary.com/glossodynia DJ, SS, YH a digestive system AE that has an outcome of a burning or tingling sensation on the lips, tongue or entire mouth burning tongue AE SIDER: C0017672 HPO: HP_0000157 glycosylated hemoglobin level decreased AE 10018482 a glycosylated hemoglobin level abnormal AE that has an outcome of decreased levels of glycosylated hemoglobin in the blood DJ, SS, YH, EB WEB: http://www.ncbi.nlm.nih.gov/pubmed/23015148 belief in likelihood of causal connection between two processes a hypothesis textual entity that represents a belief in likelihood of causal connection between process 1 and process 2. Barry Smith, Yu Lin, Oliver He graft infection AE 10056559 DJ, SS, YH an infection AE that results in a graft infection distal sensorimotor painful neuropathy a sensorimotor painful neuropathy AE which has an outcome of distal sensory neuropathy characterized by damage to sensory and motor nerves gram stain positive AE 10018656 WEB: http://medical-dictionary.thefreedictionary.com/gram+stain a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-positive bacteria DJ, SS, YH, EB grand mal convulsion AE 10018659 DJ, SS, YH, SJ tonic seizure WEB: http://www.mayoclinic.com/health/grand-mal-seizure/DS00222 a nervous system AE that results in a generalized seizure that affects the entire brain HPO: HP_0002197 SIDER: C0014549 granulocyte count decreased AE 10018681 neutropenia AE a granulocyte count abnormal AE that has an outcome of compromise to the immune system where the number of neutrophil granulocytes, a type of white blood cell, is lower than the normal range of ~1700 per microliter. DJ, SS, YH, EB belief in likelihood of causal connection between medical intervention and adverse event Barry Smith, Yu Lin, Oliver He a belief in likelihood of causal connection between two processes that represents a belief in likelihood of causal connection between medical intervention m and adverse event e. granulocytopenia AE 10018687 a hematopoietic system AE that has an outcome of a marked decrease in number of granulocytes, a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms WEB: http://www.medterms.com/script/main/art.asp?articlekey=8817 DJ, SS, YH guttate psoriasis AE 10018797 WEB: http://www.ncbi.nlm.nih.gov/pubmed/20860740 DJ, SS, YH a psorisis AE that has an outcome of psoriasis that appears on the back and extremities of the patients adverse effect a disposition that represents the likelihood of the occurrence of an adverse event after a medical intervention. YH adverse side effect gynaecomastia AE 10018800 SIDER: C0018418 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/gynecomastia HPO: HP_0000771 a male reproductive system AE that has an outcome of abnormal development of large mammary glands in males resulting in breast enlargement adverse event causality evidence evidence bearing on adverse event causality an information content entity that represents evidence for indicating the causal association between an adverse event and a medical intervention. YH hematemesis AE 10018830 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hematemesis haematemesis AE HPO: HP_0002248 a vomiting AE that results in the vomiting of blood SIDER: C0018926 hematochezia AE 10018836 haematochezia AE HPO: HP_0002573 SIDER: C0018932 a digestive system AE that has an outcome of the passage of bloody stools WEB: http://medical-dictionary.thefreedictionary.com/hematochezia DJ, SS, YH hematocrit decreased AE 10018838 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/hematocrit haematocrit decreased AE a hematocrit abnormal AE with an outcome of decreased volume percentage of red blood cells in blood hematoma infection AE 10051564 haematoma infection AE WEB: http://medical-dictionary.thefreedictionary.com/hematoma DJ, SS, YH an infection AE that has an outcome of infection in a hematoma hematotoxicity AE 10061188 haematotoxicity AE DJ, SS, YH a hematopoietic system AE that has an outcome of toxins that destroy red blood cells, disrupt blood clotting, and/or cause organ degeneration and generalized tissue damage bundle branch block left AE 10006580 WEB: http://medical-dictionary.thefreedictionary.com/left+bundle+branch+block YH, SS LBBB HPO: HP_0011713 SIDER: C0023211 left bundle branch block A conduction system disorder AE that is a condition in which ventricular contraction is not completely synchronized due to a block in conduction of an electrical impulse to the ventricles; in LBBB, right ventricular endocardial activation begins before, and is often completed before, initiation of left ventricular endocardial activation; benign LBBB is rare; preexisting LBBB in absence of clinical evidence of heart disease is rare; newly acquired LBBB has a 10-fold ↑ in mortality Clinical Generally asymptomatic, or absent or diminished 1st heart sound–HS and reversed splitting of 2nd HS EKG Lead V1–QS or rS; lead V6–late intrinsicoid deflection, monophasic R; lead I–monophasic R Management Pacemaker, if syncope or significant arrhythmias Followup Telemetry PRN. hemoglobin level abnormal AE 10018879 WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin a red blood cell profile abnormal AE that has an outcome of an abnormal count of hemoglobin, or iron-containing oxygen-transport metalloprotein in red blood cells haemoglobin abnormal AE DJ, SS, YH, EB influenza vaccine administration YH a vaccination that uses an influenza vaccine adverse drug effect 10061623 http://www.ncbi.nlm.nih.gov/pubmed/11072960 YH, SJ an adverse effect that occurs after a drug administration: an appreciably harmful or unpleasant reaction resulting from an intervention related to the use of a medicinal product hemolytic uremic syndrome AE 10018932 10019515 DJ, SS, YH HPO: HP_0005575 SIDER: C0019061 a hematopoietic system AE that has an outcome of hemolytic anemia, acute kidney failure and a low platelet count haemolytic uraemic syndrome AE CTCAE: E10043 NCIt: C75545 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307876 hemoptysis AE 10018964 HPO: HP_0002105 haemoptysis AE WEB: http://medical-dictionary.thefreedictionary.com/hemoptysis SIDER: C0019079 DJ, SS, YH a respiratory system AE that has an outcome of expectoration of blood or blood-stained sputum from the bronchi, larynx, trachea or lungs hemorrhage intracranial AE 10018985 SIDER: C0151699 DJ, SS, YH a nervous system AE that has an outcome of accumulation of blood within the cranial vault HPO: HP_0002170 haemorrhage intracranial AE WEB: http://emedicine.medscape.com/article/1163977-overview hemorrhagic ovarian cyst AE 10060781 haemorrhagic ovarian cyst AE DJ, SS, YH a female reproductive system AE that results in a 'blood cyst' where the walls of ovarian cysts are lined with blood vessels, which when rupture fill the cyst with blood. haemorrhoid operation 10059624 DJ, SS, YH a surgery that removes hemorroids WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid outcome of adverse event causality evidence an information content entity that represents the outcome of the evidences used for seeking the causal association between an adverse event and a medical intervention. YH hemorrhoidal hemorrhage AE 10054787 10060640 CTCAE: E10767 WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid DJ, SS, YH NCIt: C78337 a digestive system AE that has an outcome of bleeding in hemorrhoids, vascular structures in the anal canal which help with stool control haemorrhoidal haemorrhage AE hemorrhoids AE 10019022 10019611 CTCAE: E10773 haemorrhoids AE HPO: HP_0004296 a digestive system AE that has an outcome of painful, swollen veins in the lower portion of the rectum or anus DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001337/ NCIt: C26792 hemothorax AE 10019027 DJ, SS, YH haemothorax AE a lung disorder AE that has an outcome of a collection of blood in the space between the chest wall and the lung WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001183/ hair growth abnormal AE 10019044 WEB: http://medical-dictionary.thefreedictionary.com/Hair+growth a hair AE that has an outcome of abnormal growth of facial or body hair HPO: HP_0010720 SIDER: C0232409 DJ, SS, YH adverse event causality score adverse event causal association score YH adverse event causality assessment score an information content entity that represents a score or probability that an adverse event is likely caused (induced) by a medical intervention. hemoglobin level decreased AE 10018884 DJ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin a hemoglobin level abnormal AE with an outcome of decrease in amount of iron-containing oxygen-transport metalloprotein in the red blood cells haemoglobin decreased AE hepatic cirrhosis AE 10019641 SIDER: C0023890 a liver/biliary system AE that has an outcome of a chronic degenerative disease in which normal liver cells are damaged and then replaced by scar tissue DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Hepatic+cirrhosis HPO: HP_0001394 hepatic enzyme increased AE 10060795 DJ, SS, YH HPO: HP_0002910 WEB: http://www.mayoclinic.com/health/elevated-liver-enzymes/MY00508 elevated liver enzyme AE a lab test abnormal AE that has an outcome of an increase in amount of hepatic enzyme in body, a liver/biliary system AE that has an outcome of elevated levels of liver enzymes, commonly ALT and AST, may indicate inflammation or damage to liver cells SIDER: C0235996 hepatic failure AE 10019663 a liver/biliary system AE that has an outcome of the inability of the liver to perform its normal synthetic and metabolic function WEB: http://medical-dictionary.thefreedictionary.com/liver+failure HPO: HP_0001399 NCIt: C26922 DJ, SS, YH CTCAE: E11211 SIDER: C0085605 hepatic infarction AE 10019680 DJ, SS, YH a liver/biliary system AE that results in incorrect blood flow to liver WEB: http://archinte.jamanetwork.com/article.aspx?articleid=571358 adverse vaccine effect an adverse effect that occurs after administration of a vaccine. YH hepatic lesion AE 10061998 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21275132 DJ, SS, YH a liver/biliary system AE with an outcome of a lesion, an abnormality in the tissue caused by disease or trauma, located in the liver hepatic necrosis AE 10019692 WEB: http://medical-dictionary.thefreedictionary.com/hepatic+necrosis NCIt: C78340 a liver/biliary system AE that has an outcome of death of hepatic parenchyma which may be single cell, or multicell in piecemeal, focal, periacinar, midzonal, periportal or paracentral locations SIDER: C0151798 CTCAE: E11221 DJ, SS, YH HPO: HP_0002605 hepatic neoplasm AE 10019695 HPO: HP_0002896 DJ, SS, YH SIDER: C0023903 a tumor AE that has an outcome of a malignant tumor in the liver WEB: http://www.ncbi.nlm.nih.gov/pubmed/23302476 acanthosis nigricans AE 10000350 黑棘皮病 WEB: http://en.wikipedia.org/wiki/Acanthosis_nigricans Acanthosis nigricans AE is a skin AE that is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead, and other areas. JX, LW, YH hepatitis B AE 10019731 DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001324/ a hepatitis AE that has an outcome of irritation and swelling of the liver due to infection with the heptitis B virus HPO: HP_0006562 SIDER: C0019163 hepatitis viral AE 10019799 DJ, SS, YH SIDER: C0042721 HPO: HP_0006562 WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis CTCAE: E11410 NCIt: C35124 a hepatitis AE that has an outcome of liver inflammation due to a hepatitis viral infection hepatomegaly AE 10019842 a liver/biliary system AE that has an outcome of swelling of the liver DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003275.htm SIDER: C0019209 HPO: HP_0002240 hepatotoxicity AE 10019851 DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/hepatotoxicity a liver damage AE that has an outcome of chemically driven liver damage Afluria administration YH an influenza vaccine administration that uses Afluria hidradenitis AE 10020040 WEB: http://medical-dictionary.thefreedictionary.com/hidradenitis DJ, SS, YH an inflammation AE that has an outcome of an inflammatory infiltrate around the eccrine sweat gland histiocytosis hematophagic AE 10048595 histiocytosis haematophagic AE an immune system disorder AE that has an outcome of abnormal proliferation of histiocytes, a type of immune cell that eats foreign substances WEB: http://www.medterms.com/script/main/art.asp?articlekey=11478 DJ, SS, YH histoplasmosis disseminated AE 10020144 DJ, SS, YH a fungal infection AE that results in an infection that occurs from breathing in the spores of the fungus Histoplasma Capsulatum WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001082.htm caesarean section 10006924 A surgery where incisions are made through a woman's abdomen and uterus to deliver her baby. WEB: http://medical-dictionary.thefreedictionary.com/cesarean+section YH, SS cesarean section hydronephrosis AE 10020524 HPO: HP_0000126 a urinary system AE that has an outcome of distension and dilation of the renal pelvis and calyces, usually caused by the osbtruction of urine flow from the kidney DJ, SS, YH SIDER: C0020295 WEB: http://medical-dictionary.thefreedictionary.com/hydronephrosis hyperbilirubinemia neonatal AE 10020580 a congenital abnormality AE that results in the yellowing of the skin of infants hyperbilirubinaemia neonatal AE DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/neonatal+jaundice hypercalcemia AE 10020583 10020587 HPO: HP_0003072 SIDER: C0020437 CTCAE: E12270 NCIt: C3112 YH, MW hypercalcaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypercalcemia a blood calcium abnormal AE that has an outcome of an elevated calcium level in the blood, above normal range of 9-10.5 mg/dL hyperhidrosis AE 10020642 WEB: http://medical-dictionary.thefreedictionary.com/hyperhidrosis CTCAE:E13645 a skin AE that results in excess perspiration HPO: HP_0000975 SIDER: C0020458 NCIt:C78345 DJ, SS, YH, MW hyperkalemia AE 10020646 10020647 CTCAE: E12282 a blood potassium abnormal AE that has a lab test outcome of an abnormally increased concentration of potassium in blood HPO: HP_0002153 SIDER: C0020461 hyperkalaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia NCIt: C37968 YH, MW toxin-induced cardiomyopathy AE cocaine-induced cardiomyopathy AE hyperparathyroidism secondary AE 10020708 HPO: HP_0003106 DJ, SS, YH an abnormal fluid regulation AE that has an outcome of an excessive secretion of the parathyroid hormone by the parathyroid gland SIDER: C0020503 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23267748 paraparesis AE 10033885 a paresis AE that shows muscle weakness affecting the lower limbs. WEB: http://www.merriam-webster.com/medical/paraparesis JX, YH 下肢轻瘫 hypertensive crisis AE 10020802 DJ, SS, YH HPO: HP_0000875 SIDER: C0020546 a systemic hypertension AE that has an outcome of hypertension with systolic blood pressure >180 mm Hg or a diastolic pressure >120 mm, can be further classified as hypertensive urgency or hypertensive emergency depending on end-organ involvement WEB: http://www.ncbi.nlm.nih.gov/pubmed/20160537 hypertriglyceridemia AE 10020869 10020870 SIDER: C0020557 HPO: HP_0002155 DJ, SS, YH, MW CTCAE: E12299 a hematopoietic system AE that has an outcome of high blood levels of triglycerides, abundant fatty molecules WEB: http://medical-dictionary.thefreedictionary.com/hypertriglyceridemia NCIt: C37971 hypertriglyceridaemia AE hyperuricemia AE 10020903 10020907 NCIt: C3961 HPO: HP_0002149 gout AE CTCAE: E12305 DJ, SS, YH, MW an arthritis AE that has an outcome of uric acid building up in blood and causes joint inflammation SIDER: C0740394 hyperuricaemia AE WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/ hypoalbuminemia AE 10020942 10020943 CTCAE: E12310 SIDER: C0239981 NCIt: C37972 hypoalbuminaemia AE a blood albumin abnormal AE that shows an abnormally low level of albumin protein in the blood. WEB: http://medical-dictionary.thefreedictionary.com/hypoalbuminemia HPO: HP_0003073 DJ, SS, YH hypocalcemia AE 10020947 10020949 NCIt: C37973 WEB: http://medical-dictionary.thefreedictionary.com/hypocalcemia hypocalcaemia AE 低血钙 a blood calcium abnormal AE that has an outcome of abnormally low calcium levels, can present with convulsions, arrythmias, tetany and numbness YH, MW HPO: HP_0002901 SIDER: C0020598 CTCAE: E12316 hypocapnia AE 10020952 WEB: https://en.wikipedia.org/wiki/Hypocapnia a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally low. DJ, SS, YH, MW UMLS CUI: C0085383 hypoglycemia AE 10020993 10021005 SIDER: C0020615 hypoglycaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypoglycemia CTCAE: E12322 a glucose homeostasis AE that results in a abnormally diminished content of glucose in the blood DJ, SS, YH, MW HPO: HP_0005969 NCIt: C3126 Glascow coma scale abnormal AE 10069709 a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of the recording of the level of consciousness in a person after a brain injuiry. Clinicians use the Galscow coma scale to rate the best eye opening response, the best verbal response, and the best motor response an individual makes. The final GCS score or grade is the sum of these numbers. YH, SJ WEB: http://www.brainline.org/content/2010/10/what-is-the-glasgow-coma-scale.html hypomagnesemia AE 10021027 10021028 HPO: HP_0002917 YH, MW UMLS CUI: C0151723 WEB: http://medical-dictionary.thefreedictionary.com/Hypomagnesaemia NCIt: C37975 SIDER: C0151723 hypomagnesaemia AE a blood magnesium abnormal AE that has an outcome of an abnormal concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors. CTCAE: E12333 intraventricular conduction delay AE a conduction system disorder AE that refers to the slow conduction of electricity through ventricular walls of the heart. SS IVCD BOOK: Taber's Cyclopedic Medical Dictionary;2005, p1134 WEB: http://connection.ebscohost.com/c/reference-entries/21232773/intraventricular-conduction-delay hypophagia AE 10063743 WEB: http://medical-dictionary.thefreedictionary.com/hypophagia DJ, SS, YH a gustatory system AE with an outcome of reduced food intake hypophosphatemia AE 10021058 10021059 NCIt: C37977 DJ, SS, YH, MW a hematopoietic system AE that has an outcome of abnormally low phosphate levels, can present with muscle dysfunction, white cell dysfunction, pulp chambers and mental status changes hypophosphataemia AE HPO: HP_0008285 UMLS CUI: C0085682 CTCAE: E12344 SIDER: C0085682 WEB: http://medical-dictionary.thefreedictionary.com/hypophosphatemia hypothyroidism AE 10021114 HPO: HP_0008245 SIDER: C0020676 an endocrine system AE with the outcome of the thyroid gland does not make enough thyroid hormone DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001393/ NCIt: C26800 CTCAE: E10334 hypovolemia AE 10021137 a cardiovascular disorder AE that is characterized by decreased blood plasma volume DJ, SS, YH HPO: HP_0011106 hypovolaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hypovolemia SIDER: C0546884 Flumist administration an influenza vaccine administration that uses Flumist YH hypovolemic shock AE 10021138 a cardiovascular disorder AE that has the outcome of severe blood and fluid loss that makes the heart unable to pump enough blood to the body, often leads to organ failure hypovolaemic shock AE HPO: HP_0011106 DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000167.htm SIDER: C0020683 ileal perforation AE 10021305 DJ, SS, YH a digestive system AE that has an outcome of holes in the ileum of the small intestine WEB: http://medical-dictionary.thefreedictionary.com/ileum NCIt: C78355 CTCAE: E10795 ileus AE 10021328 HPO: HP_0002595 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/ DJ, SS, YH intestinal obstruction AE a digestive system AE that has an outcome of a partially or completely blocked bowel SIDER: C1258215 CTCAE: E10812 NCIt: C37979 ileus paralytic AE 10021333 DJ, SS, YH WEB: http://www.localhealth.com/article/paralytic-ileus SIDER: C0030446 HPO: HP_0002590 a digestive system AE that has an outcome of intestinal blockage in the absence of an actual physical obstruction, can be caused by a malfunction in nerves and muscles in the intestine cardiomegaly AE 10007632 A cardiac disorder AE that has an outcome of an abnormal enlargement of the heart HPO: HP_0001640 WEB: http://medical-dictionary.thefreedictionary.com/cardiomegaly YH, SS added MedDRA term LB SIDER: C0018800 immunosuppressant drug level decreased AE 10062014 WEB: http://medical-dictionary.thefreedictionary.com/Immunosuppresant a drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body DJ, SS, YH immunosuppression AE 10062016 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001821/ DJ, SS, YH an immune system disorder AE that has an outcome of reduced or absent immune response impaired healing AE 10021519 WEB: http://medical-dictionary.thefreedictionary.com/wound+healing SIDER: C0151692 an injury AE that has an outcome of impairment to the process of restoring a state of soundness to any interupption in the continuity of external surfaces of the body DJ, SS, YH HPO: HP_0001058 implant site pain AE 10063782 DJ, SS, YH a pain AE that has an outcome of pain at the site of an implant no evidence bearing on an adverse event causal relation Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. YH an outcome of adverse event causality evidence that has an outcome of no evidence bearing on a AE causal relation. increased viscosity of bronchial secretion AE 10054761 DJ, SS, YH a respiratory system AE that has an outcome of increased thickness of the secretions of the bronchi infection parasitic AE 10021857 an infection AE that results in infection by a parasite SIDER: C0747256 DJ, SS, YH HPO: HP_0002719 infection susceptibility increased AE 10021866 HPO: HP_0002719 SIDER: C0236171 an immune system disorder AE that has an outcome of increased susceptibility to infection DJ, SS, YH infective pulmonary exacerbation of cystic fibrosis AE 10070608 an infection AE that has an outcome of an increase in severity of cystic fibrosis in the patient SZ, DJ, SS, YH preventive intervention YH a medical intervention that is used for preventive purpose infusion related reaction AE 10051792 10053483 WEB: http://www.ons.org/Publications/VJC/media/ons/docs/publications/VJC/vjc-apr10cjon.pdf a immune system AE that results in an allergic reaction to foreign protein, but can also be caused by cytokine release. SZ, DJ, SS, YH NCIt: C78361 CTCAE: E11127 infusion site extravasation AE 10064774 CTCAE: E11133 NCIt: C78362 an extravasation AE that has an outcome of leaking of pharmacologic or biological substance from infusion site into surrounding tissue. Symptoms include induration, erythema, swelling, burning sensation and pain WEB: http://medical-dictionary.thefreedictionary.com/extravasation SZ, DJ, SS, YH infusion site infection AE 10054997 SZ, DJ, SS, YH Infection AE that results in the patient gets infected at the sight of an infusion infusion site rash AE 10059830 Rash AE that results in patient has a rash at the site of infusion SZ, DJ, SS, YH infusion site reaction AE 10054996 SZ, DJ, SS, YH an allergy AE that has an outcome of infusion site allergic reaction ingrowing nail AE 10022013 SZ, DJ, SS, YH a nail disorder AE that results in a nail growing into the sides of the paronychium WEB: http://medical-dictionary.thefreedictionary.com/ingrowing+nail injection-site macule AE 10067255 WEB: http://medical-dictionary.thefreedictionary.com/macule SZ, DJ, SS, YH a skin discoloration AE that results in a discoloration of the skin at the site of injection of the drug injection-site phlebitis AE 10022090 WEB: http://medical-dictionary.thefreedictionary.com/phlebitis SZ, DJ, SS, YH Inflammation AE that results in swelling of the veins at the site of drug injection cataract operation 10063797 A surgery that is a procedure to remove the lens of your eye and, in most cases, replace it with an artificial lens. Cataract surgery is used to treat a cataract YH, SS cataract surgery injection-site scab AE 10066210 SZ, DJ, SS, YH an adverse event that results in the patient developing a scab at the site of drug injection instillation site pain AE 10022459 a pain AE that results in pain at the site of instillation WEB: http://medical-dictionary.thefreedictionary.com/instillation SZ, DJ, SS, YH intention tremor AE 10022520 SZ, DJ, SS, YH HPO: HP_0002345 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23094990 SIDER: C0234376 a tremor AE that results in the patient undergoing a broad, coarse, low frequency muscle tremor intentional drug misuse AE 10065679 SZ, DJ, SS, YH an adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc) intentional overdose AE 10022523 SZ, DJ, SS, YH an incorrect dose administration AE that results in overdosing on the drug on purpose interstitial lung disease AE 10022611 SIDER: C0206062 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23289473 SZ, DJ, SS, YH a lung disorder AE that has an outcome of a disease affecting the interstitium, the tissue and space around the air sacs of the lungs HPO: HP_0006530 intervertebral disc protrusion AE 10050296 SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/herniation+of+intervertebral+disk a bone disorder AE that has an outcome of the protrusion of the nucleus pulposus or anulus fibrosus of the intervertebral disk, which may impinge on nerve roots intestinal ischemia AE 10022680 intestinal ischaemia AE an ischaemia AE that has an outcome of blocked or narrowed blood vessels to the small or large intestines, can cause pain and permanent damage to the intestines SZ, DJ, SS, YH intestinal obstruction AE 10022687 a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors SIDER: C0021843 HPO: HP_0005250 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/ SZ, DJ, SS, YH intestinal perforation AE 10022694 a gastrointestinal disorder AE that has an outcome of perforation, or complete penetration, of the wall of the intestines SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/ intracardiac thrombus AE 10048620 SZ, DJ, SS, YH a thrombosis AE that has an outcome of thrombi in the ventricles WEB: http://www.cvimaging.northwestern.edu/for-physicians/cardiovascular-mri/indications/intracardiac-thrombus/ intracranial pressure increased AE 10022773 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000793.htm SIDER: C0151740 HPO: HP_0002516 a nervous system AE that has an outcome of a rise in the pressure inside the skull that can result from or cause brain injury SZ, DJ, SS, YH intraocular pressure test result abnormal AE 10060951 a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal intraocular pressure in the eye SZ, DJ, SS, YH, EB intussusception AE 10022863 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000958.htm a gastrointestinal disorder AE that results in part of the intestine invaginating itself into another part of the intestine SIDER: C0021933 HPO: HP_0002576 MP: MP_0003294 SZ, DJ, SS, YH According to the Vaccine Adverse Event Reporting System (VAERS), 'intussusception'; is an adverse event that was mentioned in 143 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). iron deficiency anemia AE 10022972 iron deficiency anaemia AE an anemia AE that has an outcome of fewer healthy red blood cells because the body does not have enough iron SIDER: C0162316 SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000584.htm HPO: HP_0001891 irritability AE 10022998 SZ, DJ, SS, YH SIDER: C0022107 HPO: HP_0000737 Behavior and Neurological AE that results in the patient being easily annoyed/irritated NCIt: C50623 CTCAE: E11144 feverish (subjective) AE jaundice cholestatic AE 10023129 cholestasis jaundice AE WEB: http://medical-dictionary.thefreedictionary.com/cholestatic+jaundice HPO: HP_0006575 SZ, DJ, SS, YH SIDER: C0022354 a jaundice AE that results in an abnormal bile flow in the liver jaw disorder AE 10061257 a bone disorder AE that has an outcome of disease in the set of bones that hold the teeth SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/jawinjuriesanddisorders.html jaw fracture AE 10023149 SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000019.htm a bone disorder AE that has an outcome of break in the jaw bone jugular vein thrombosis AE 10023237 a thrombosis AE with an outcome of formation of a blood clot located in the internal jugular vein SZ, DJ, SS, YH klebsiella infection AE 10061259 SIDER: C0022729 a bacterial infection AE with an outcome of invasion by Klebsiella pneumonia, a form of bacterial pneumonia HPO: HP_0002742 WEB: http://www.ncbi.nlm.nih.gov/pubmed/17307769 SZ, DJ, SS, YH knee deformity AE 10062061 SZ, DJ, SS, YH a bone disorder a that results in the knee becoming deformed lack of spontaneous speech AE 10023615 a speech disorder AE that results in the inability of a patient to speak properly SZ, DJ, SS, YH large for dates baby AE 10023789 SZ, DJ, SS, YH a congetical abnormality AE that results in the patient's baby being larger than it should be at the time in their pregnancy large granular lymphocytosis AE 10023791 SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/10761014 an immune system disorder AE that has an outcome of an increase in the number or proportion of natural killer cells, or cytotoxic lymphocytes critical to the innate immune system large intestinal ulcer AE 10023799 SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Intestinal+ulcer a gastrointestinal disorder AE that has an outcome of an ulcer in the large intestine large intestine perforation AE 10023804 HPO: HP_0002250 a digestive system AE that has an outcome of perforation, or complete penetration, of the walls of the large intestine SIDER: NA WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000235.htm SZ, DJ, SS, YH le cells present AE 10024062 WEB: http://medical-dictionary.thefreedictionary.com/LE+cell SZ, DJ, SS, YH, EB an immunology and allergy investigation result abnormal that results in LE cells (neutrophil or macrophage that has phagocytized the denatured nuclear material of another cell) being detected left atrial dilatation AE 10067286 a dilatation atrial AE that results in the left atrium of the heart becoming enlarged WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096293/ SZ, DJ, SS, YH left ventricular dysfunction AE 10049694 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766527/ SZ, DJ, SS, YH CTCAE: E10130 a cardiac ventricular disorder AE that has an outcome of inability of the left ventricle to pump blood, may lead to heart failure NCIt: C64251 left ventricular failure AE 10024119 HPO: HP_0001635 SIDER: C0023212 WEB: http://medical-dictionary.thefreedictionary.com/left+ventricular+failure SZ, DJ, SS, YH a left ventricular dysfunction AE that has an outcome of congestive heart failure marked by pulmonary congestion and edema, the left ventricle fals to contract forcefully enough to maintain normal cardiac output and peripheral perfusion left ventricular hypertrophy AE 10049773 a left ventricular dysfunction disorder AE that has an outcome of the thickening of the myocardium of the left ventricle of the heart SZ, DJ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/18030317 leukemia recurrent AE 10062489 WEB: http://www.yourcancertoday.com/Cancers/Leukemia-Acute-Myeloid-Adult/53 leukaemia recurrent AE a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by return of symptoms after remission SZ, DJ, SS, YH leukemic infiltration brain AE 10064987 WEB: http://www.ncbi.nlm.nih.gov/pubmed/1454121 SZ, DJ, SS, YH a nervous system AE that has an outcome of cancerous white blood cells infiltrating the brain leukaemic infiltration brain AE leukemoid reaction AE 10024328 leukaemoid reaction AE HPO: HP_0001909 SIDER: C0023501 SZ, DJ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000575.htm Immune system disorder AE that results in an increase in white blood cell count as a result of stress or infection evidence inadequate to accept or reject an adverse event causal relation YH an outcome of adverse event causality evidence that has an outcome of evidence is inadequate to accept or reject an adverse event causal relation Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. leukocytoclastic vasculitis AE 10024377 白细胞破碎性血管炎 HPO: HP_0011944 an vasculitis AE that has an outcome of fragmented cells, and debris in the blood vessels. May develop skin lesions, accompanied by arthralgia and fever WEB: http://medical-dictionary.thefreedictionary.com/leukocytoclastic+vasculitis SIDER: C2973529 SZ, DJ, SS, YH leukocyturia AE 10050791 Urinary system AE that results in white blood cells in the urine WEB: http://medical-dictionary.thefreedictionary.com/leukocyturia SZ, DJ, SS, YH leukoencephalopathy AE 10024382 CTCAE:E12712 HPO: HP_0002352 SZ, DJ, SS, YH, MW SIDER: C0270612 NCIt:C27059 WEB: http://medical-dictionary.thefreedictionary.com/leukoencephalopathy an encephalopathy AE that has an outcome of brain white matter disease leukopenia AE 10024384 SIDER: C0023530 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154209/ HPO: HP_0001882 a hematopoietic system AE that has an outcome of a lower than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue SZ, DJ, SS, YH libido disorder AE 10061221 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695750/ SZ, DJ, SS, YH a psychiatric disorder AE that results in a disorder in the patient's desire for sexual interaction lichen planus AE 10024429 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001870/ a skin AE that has an outcome of an itchy rash on the skin or in the mouth SZ, DJ, SS, YH lip erosion AE 10051992 a skin erosion AE that results in the deterioration of the lip skin SZ, DJ, SS, YH lipase increased AE 10024574 CTCAE: E12185 WEB: http://www.ncbi.nlm.nih.gov/pubmed/15653991 a digestive system AE that has an outcome of an excess of lipase, a pancreatic enzyme, may indicate a problem related to pancreas hyperlipasemia AE NCIt: C78435 SZ, DJ, SS, YH central venous catheterisation 10053377 WEB: http://www.nlm.nih.gov/medlineplus/ency/patientinstructions/000157.htm A medical intervention that is a tube going into a vein in your chest. It will help carry nutrients and medicine into your body. It will also be used to take blood when you need to have blood tests. YH, SS liver AE 10024670 WEB: http://www.nlm.nih.gov/medlineplus/liverdiseases.html Liver/biliary system AE that results in the disease of the liver SIDER: C0023895 SZ, DJ, SS, YH HPO: HP_0006706 liver disorder local swelling AE 10024770 SZ, DJ, SS, YH a localized edema AE that shows the outcome of swelling. localized infection AE 10024774 an infection AE located in a certain area localised infection AE HPO: HP_0002719 SZ, DJ, SS, YH SIDER: C0016397 localised intraabdominal fluid collection AE 10066768 Abnormal fluid regulation AE that results in a collection of fluid in the intraabdominal area WEB: http://medical-dictionary.thefreedictionary.com/intra-abdominal SZ, DJ, SS, YH localized edema AE 10048961 10062466 SIDER: C0013609 CTCAE: E11148 NCIt: C78437 HPO: HP_0000969 SZ, DJ, SS, YH localised oedema AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115975/ an edema AE occuring in a specific region localised edema AE loss of proprioception AE 10057332 SZ, DJ, SS, YH a movement disorder AE that has an outcome of loss of the sense of the relative position of neighbouring parts of the body and strength of effort being employed in movement WEB: http://www.ncbi.nlm.nih.gov/pubmed/8294975 lower gastrointestinal hemorrhage AE 10050953 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003133.htm lower gastrointestinal haemorrhage AE SZ, DJ, SS, YH a gastrointestinal hemorrhage AE that has an outcome of bleeding in the lower gastrointestinal tract SIDER: C0024050 HPO: HP_0002239 lower respiratory tract infection AE 10024968 WEB: http://www.ncbi.nlm.nih.gov/books/NBK8142/ an infection AE that has an outcome of infection in the lower respiratory tract, includes pneumonea as well as lung abscess and acute bronchitis HPO: HP_0002783 SIDER: C0149725 SZ, DJ, SS, YH lung consolidation AE 10025080 pulmonary consolidation AE SZ, DJ, SS, YH a lung disorder AE that has an outcome of liquid filling a region of lung tissue, marked by induration of a normally aerated lung WEB: http://medical-dictionary.thefreedictionary.com/consolidation lung infection AE 10061229 WEB: http://www.livestrong.com/lung-infection/ HPO: HP_0002783 an infection AE that has an outcome of infection in the lungs SIDER: C0876973 CTCAE: E11444 SZ, DJ, SS, YH NCIt: C26873 lung infiltration AE 10025102 SZ, DJ, SS, YH SIDER: C0235896 HPO: HP_0005828 a lung disorder AE that has an outcome of an abnormal presence of granulomas, fluid, inflammatory exudates or cells in the lung tissue WEB: http://www.blurtit.com/q840550.html lung neoplasm AE 10062042 SIDER: C0024121 a tumor AE that has an outcome of a malignant tumor in the lung HPO: HP_0100526 SZ, DJ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Lung+neoplasm lymphadenopathy AE 10025197 HPO: HP_0002716 SIDER: C0497156 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/lymphadenopathy an immune system disorder AE that has an outcome of lymphadenopathy, which is a term meaning "disease of the lymph nodes" . It is generally a disease or inflammation of the lymph nodes, could be due to infection, auto-immune disease or malignancy lymphangiosis carcinomatosa AE 10053132 an inflammation AE occuring in the lymph vessels secondary to a malignancy WEB: http://www.ncbi.nlm.nih.gov/pubmed/8930034 SZ, SS, YH lymphocyte count decreased AE 10025256 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm SZ, SS, YH a lymphocyte count abnormal AE that has an outcome of a decreased amount of lymphocytes in the blood, a type of white blood cell in the immune system CTCAE: E12190 NCIt: C26823 lymphocyte percentage increased AE 10052232 a lymphocyte percentage abnormal AE that results in an increase in the levels of lymphocytes in the blood SZ, SS, YH, EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm lymphocytic infiltration AE 10062049 an immune system disorder AE that results in lymphocytes being infiltrated by harmful substances SZ, SS, YH WEB: http://emedicine.medscape.com/article/1098654-overview lymphocytosis AE 10025280 an immune system disorder AE that has an outcome of an increase in the number or proportion of lymphocytes in the blood HPO: HP_0012141 WEB: http://medical-dictionary.thefreedictionary.com/lymphocytosis SIDER: C0024282 SZ, SS, YH lymphoedema AE 10025282 SIDER: C0024236 WEB: Primary Source: http://emedicine.medscape.com/article/1087313-overview Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23073712 an edema AE that has an outcome of localized fluid retention and tissue swelling caused by a compromised lymphatic system HPO: HP_0001004 SZ, SS, YH lymphopenia AE 10025327 SZ, SS, YH a hematopoietic system AE that has an outcome of reduction in the number of lymphocytes in the blood WEB: http://medical-dictionary.thefreedictionary.com/lymphopenia SIDER: C0024312 HPO: HP_0001888 macular degeneration AE 10025409 SIDER: C0024437 a eye disorder AE that has an outcome of cell death in the macula of the eye, destroying central vision HPO: HP_0007673 WEB: http://www.nlm.nih.gov/medlineplus/maculardegeneration.html SZ, SS, YH male orgasmic disorder AE 10025513 SZ, SS, YH a male reproductive system disorder AE that results in the inability of the male to achieve an orgasm despite lengthy sexual contact WEB: http://www.minddisorders.com/Kau-Nu/Male-orgasmic-disorder.html#b malignant neoplasm progression AE 10061309 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19824467 a tumor AE that has an outcome of growth or proliferation of an abnormal mass of tissue malignant pleural effusion AE 10026673 WEB: http://www.ncbi.nlm.nih.gov/pubmed/11529302 SZ, SS, YH an respiratory system AE that has an outcome of abnormal amount of fluid collecting between the layers of tissue lining the outside of the lung and wall of chest cavity, caused by cancer colectomy 10061778 YH, SS A surgery that is a surgical procedure to remove all or part of your colon. WEB: http://www.mayoclinic.com/health/colectomy/MY00141/METHOD=print mammoplasty 10068647 a surgery that is performed to change the size of breasts WEB: http://medical-dictionary.thefreedictionary.com/mammoplasty SZ, SS, YH coronary artery disorder AE 10011078 10011082 YH, SS an arterial disorder AE that resuts in arteries that supply blood to heart muscle become hardened and narrowed. WEB: http://www.nlm.nih.gov/medlineplus/coronaryarterydisease.html coronary artery disese AE marrow hyperplasia AE 10026851 WEB: http://www.mayoclinic.com/health/aplastic-anemia/DS00322/DSECTION=causes SZ, SS, YH a hematopoietic system AE that has an outcome of bone marrow that contains an excess of blood cells maternal drugs affecting fetus AE 10026923 SZ, SS, YH maternal drugs affecting foetus AE a perinatal AE that results in the drugs being taken by the mother affecting unborn fetus in mother mediastinal disorder AE 10061280 WEB: http://medical-dictionary.thefreedictionary.com/Mediastinal+diseases HPO: HP_0000765 an adverse event that results in a problem in the mediastinum of the patient (undelineated group of structures in the thorax surrounded by loose connective tissue) SIDER: C0025061 SZ, SS, YH megacolon AE 10027110 HPO: HP_0002251 WEB: http://medical-dictionary.thefreedictionary.com/megacolon a digestive system AE that has an outcome of abnormal dilation of the colon, often accompanied by paralysis of the peristaltic movements of the bowel SZ, SS, YH SIDER: C0025160 melena AE 10027141 HPO: HP_0002249 Abnormal defecation AE that results in black feces associated with gastrointestinal hemorrhage melaena AE SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003130.htm SIDER: C0025222 memory impairment AE 10027175 SIDER: C0233794 Behavior and Neurological AE that results in the loss of memory SZ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/impaired+memory NCIt:C78444 CTCAE:E12718 HPO: HP_0002354 meningitis aseptic AE 10027201 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/aseptic+meningitis HPO: HP_0001287 SIDER: C0025290 a brain inflammation AE that results in the layers lining the brain becoming inflamed, not due to pygonenic bacteria menometrorrhagia AE 10027295 Hematuria AE that results in excessive uterine bleeding occurs irregularly and more frequently than normal HPO: HP_0100608 SZ, SS, YH SIDER: C0232943 WEB: http://medical-dictionary.thefreedictionary.com/menometrorrhagia menorrhagia AE 10027313 NCIt:C26829 HPO: HP_0000132 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0014910/ Female Reproductive System AE that results in abnormally heavy and prolonged menstrual period CTCAE:E13132 SZ, SS, YH, MW SIDER: C0025323 mental status changes AE 10048294 A mental status change does not have to be a disorder or even an adverse event. It can be a good change, from a disorder status to a normal recovered status. WEB: http://www.medicinenet.com/altered_mental_status/symptoms.htm SZ, SS, YH, Izabela Birsanescu a psychiatric disorder AE that has an outcome of changes in mental status metabolic disorder AE 10058097 SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/metabolicdisorders.html a metabolism, endocrine, and exocrine system AE that has an outcome of abnormal chemical reactions in the body that disrupts a metabolic process dilatation atrial AE 10013002 atrial dilatation, atrial enlargement YH, SS A cardiac disorder AE that has an outcome of enlargement of the heart metastasis to abdominal cavity AE 10027450 WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/19373966 SZ, SS, YH an abdominal AE that shows the spreading of the cancer cells to the abdominal cavity of the patient metastasis to bone AE 10027452 a tumor AE that has an outcome of cancerous cells spreading to the bone from elsewhere SZ, SS, YH metastasis to central nervous system AE 10059282 a tumor AE that results in cancerous cells spreading from a primary tumor to the central nervous system WEB: http://theoncologist.alphamedpress.org/content/8/5/398.long, http://www.ncbi.nlm.nih.gov/pubmed/19373966 SZ, SS, YH metastasis to liver AE 10027457 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000277.htm a tumor AE that results in cancerous cells spreading to the liver organ SZ, SS, YH metastasis to lung AE 10027458 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000097.htm a tumor AE that results in cancerous cells spreading to the lung SZ, SS, YH metastasis to meninges AE 10051696 WEB: 1. http://theoncologist.alphamedpress.org/content/1/1/56.full 2. http://www.cancer.gov/dictionary?cdrid=45782 meningeal metastasis AE SZ, SS, YH a tumor AE that has an outcome cancerous cells spreaing from primary tumor to the thin layers of tissue that protect the brain and spinal cord, may experience increased intracranial pressure metastasis to peritoneum AE 10051676 a tumor AE that results in cancerous cells spreading from primary tumor to the lining of the abdominal cavity or the coelom. WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/peritoneum Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed?term=metastasis%20to%20peritoneum%20%5BTI%5D SZ, SS, YH metastasis to pleura AE 10027463 WEB: http://www.nlm.nih.gov/medlineplus/pleuraldisorders.html SZ, SS, YH a tumor AE that results in a disease spreading to the pleural cavity due to cancerous activities evidence favoring rejection of an adverse event causal relation an outcome of adverse event causality evidence that has an outcome of evidence favors rejection of an adverse event causal relation YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. metastasis to spine AE 10027468 WEB: http://emedicine.medscape.com/article/1157987-overview SZ, SS, YH a tumor AE that results in cancerous cells spreading to the spine metastasis AE 10062194 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm SZ, SS, YH a tumor AE with an outcome of spreading of disease from one organ to another non-adjacent organ or part metastatic neoplasm AE 10061289 SZ, SS, YH a tumor AE with an outcome of spreading of cancerous cells from abnormal mass of tissue WEB: http://www.ncbi.nlm.nih.gov/pubmed/20121607 metrorrhagia AE 10027514 HPO: HP_0100608 Urinary System AE that is characterized by uterine bleeding at irregular intervals SZ, SS, YH SIDER: C0025874 WEB: http://medical-dictionary.thefreedictionary.com/metrorrhagia microangiopathic hemolytic anemia AE 10027527 HPO: HP_0001937 SIDER: C0221021 microangiopathic haemolytic anaemia AE Cardiovascular disorder AE that results in a fragmentation of red blood cells resulting from the narrowing of small blood vessels WEB: http://medical-dictionary.thefreedictionary.com/microangiopathic+hemolytic+anemia SZ, SS, YH mitral valve incompetence AE 10027727 HPO: HP_0001653 SIDER: C0026266 a cardiac valve disease AE that is characterized by the inability of the heart's mitral valve to close tightly, allowing blood to flow backward in the heart SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Mitral+Valve+Insufficiency mouth hemorrhage AE 10028024 WEB: http://sideeffects.embl.de/se/C0029163/ a digestive system AE that has an outcome of bleeding from blood vessels located in the mouth SZ, SS, YH SIDER: C0029163 mouth haemorrhage AE HPO: HP_0000167 mouth ulceration AE 10028034 a digestive system AE that has an outcome of sores or open lesions in the mouth WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001448.htm HPO: HP_0000155 aphthous stomatitis AE SZ, SS, YH canker sore AE SIDER: C0149745 multiple sclerosis relapse AE 10048393 Multiple Sclerosis AE that is characterized by a relapse of Multiple Sclerosis SZ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001747/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22980532 muscle cramp AE 10028294 WEB: http://www.nlm.nih.gov/medlineplus/musclecramps.html SZ, SS, YH a muscle contraction AE that has an outcome of painful sensations, associated with muscle fatigue and low sodium/potassium muscle enzyme level increased AE 10057945 a muscle enzyme level abnormal AE that results in an increased level of muscle enzyme SZ, SS, YH muscular dystrophy AE 10028356 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002172/ a muscle AE that results in the musculoskeletal system being weakened at locomotion is hampered musculoskeletal chest pain AE 10050819 HPO: HP_0006649 SIDER: C0476280 SZ, SS, YH WEB: http://www.uptodate.com/contents/major-causes-of-musculoskeletal-chest-pain?source=see_link a pain AE located in musculoskeletal structures of the chest wall, atypical or noncardiac chest pain mycoplasma infection AE 10061300 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/15142464 Bacterial infection AE that results in the patient being infected with the Mycoplasma bacteria evidence favoring acceptance of an adverse event causal relation Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32. an outcome of adverse event causality evidence that has an outcome of evidence favors acceptance of an adverse event causal relation YH myelodysplastic syndrome AE 10028533 CTCAE:E12552 a hematopoietic system AE that has an outcome of ineffective production of the myeloid class of blood cells HPO: HP_0006730 SIDER: C0026986 WEB: http://www.nlm.nih.gov/medlineplus/myelodysplasticsyndromes.html SZ, SS, YH, MW NCIt:C3247 myelofibrosis AE 10028537 HPO: HP_0011974 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001558/ SZ, SS, YH a hematopoietic system AE that has an outcome of bone marrow being replaced by scar tissue SIDER: C0026987 myocardial ischemia AE 10028600 SIDER: C0151744 a cardiac disorder AE that has an outcome of an imbalance between myocardial oxygen supply and demand HPO: HP_0001637 myocardial ischaemia AE WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768241/ SZ, SS, YH myocarditis AE 10028606 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001204/ SZ, SS, YH NCIt: C34831 an inflammation AE that has an outcome of inflammation of the heart muscle CTCAE: E10157 nail disorder AE 10028694 SIDER: C0027339 HPO: HP_0001597 SZ, SS, YH WEB: http://www.umm.edu/altmed/articles/nail-disorders-000116.htm a bone disorder AE, most commonly fungal infection, that is characterized by discoloration, painful swelling, pits, lesions and brown bands nail infection AE 10061304 SIDER: C0343026 SZ, SS, YH WEB: http://www.emedicinehealth.com/paronychia_nail_infection/article_em.htm a nail AE around the nail area, tends to be fungal HPO: HP_0008396 necrosis ischemic AE 10028862 WEB: http://medical-dictionary.thefreedictionary.com/ischemic+necrosis necrosis ischaemic AE Cell death AE that results in necrosis occurring due to a local deprivation of blood SZ, SS, YH neoplasm malignant AE 10028997 SZ, SS, YH SIDER: C0006826 a progressive tumor AE that has an outcome of an abnormal mass of cells that metastasizes HPO: HP_0002664 WEB: http://medical-dictionary.thefreedictionary.com/malignant+neoplasm neoplasm progression AE 10061309 an tumor AE that has an outcome of growth of the neoplasm, an abnormal mass of tissue in the body WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/neoplasm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23263846 SZ, SS, YH neoplasm recurrence AE 10061864 a tumor AE that has an outcome of microscopic cells of the original neoplasm escaping therapeutic intervention and later becoming clinically visible at the original site SZ, SS, YH nephrocalcinosis AE 10029146 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001522/ SIDER: C0027709 HPO: HP_0000121 SZ, SS, YH Kidney disorder AE that results in an increased amount of calcium deposits in the renal parenchyma nephrotic syndrome AE 10029164 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001520/ SZ, SS, YH HPO: HP_0000100 a kidney disorder AE that has an outcome of a group of symptoms that include protein in the urine, low blood protein levels, high cholesterol levels, high triglyceride levels and swelling SIDER: C0027726 nerve compression AE 10029174 WEB: http://nerve.wustl.edu/nd_compression.php SZ, SS, YH a neuropathy AE that has an outcome of direct pressure on a single nerve, can cause pain, tingling and muscle weakness nerve root compression AE 10061866 WEB: http://www.ncbi.nlm.nih.gov/pubmed/6719259 Nervous System AE that results in pressure on a root nerve SZ, SS, YH nerve root lesion AE 10029188 SZ, SS, YH Nervous system AE that results in a lesion occurring on a nerve root neurological decompensation AE 10068357 A nervous system AE that has an outcome of inability of maintaining neurological functions. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/decompensation neuroma AE 10029308 HPO: HP_0009588 SZ, SS, YH SIDER: C0027858 Tumor AE that results in a tumor growing on nerve tissue WEB: http://medical-dictionary.thefreedictionary.com/neuroma neurotoxicity AE 10029350 10067722 SZ, SS, YH, QL WEB: http://en.wikipedia.org/wiki/Neurotoxicity a nervous system AE that alters the normal activity of the nervous system due to exposure to neurotoxins (which can be natural or artificial toxic substances), and causes damage to nervous tissue toxic neuropathy AE neutralizing antibodies positive AE 10064980 SZ, SS, YH, EB neutralising antibodies positive AE an immunolgy and allergy investigation result abnormal AE that is chracterized by neutralising antibodies detected in the blood WEB: http://medical-dictionary.thefreedictionary.com/neutralizing+antibody neutropenia AE 10029354 HPO: HP_0001875 a neutropenia AE that compromises the immune system where the number of neutrophil granulocytes, a type of white blood cell, is abnormally low. A neutropenia makes body vulnerable to bacterial and fungal infections. SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/neutropenia SIDER: C0027947 neutropenia neonatal AE 10029358 WEB: http://www.thefreedictionary.com/neonatal, http://medical-dictionary.thefreedictionary.com/neonatal+neutropenia,+alloimmune a neutropenia AE that results in an abnormal number of neutrophils in a newborn infant SZ, SS, YH neutropenic colitis AE 10062959 SZ, SS, YH WEB: http://emedicine.medscape.com/article/183791-overview a gastrointestinal Inflammation AE that results in the cecum, part of the large intestine, being inflamed SIDER: C0400823 HPO: HP_0002583 neutropenic sepsis AE 10049151 a sepsis AE caused by neutropenia or an abnormally low neutrophil count WEB: http://guidance.nice.org.uk/CG151 SZ, SS, YH neutrophil count abnormal AE 10061313 SZ, SS, YH, EB WEB: http://www.medterms.com/script/main/art.asp?articlekey=20030 a white blood cell profile abnormal AE that results in an abnormal number of neutrophil granulocytes, a type of white blood cell (outside the normal range of ~1700 per microliter) neutrophil count decreased AE 10029366 SZ, SS, YH, EB WEB: http://www.mayoclinic.com/health/neutropenia/MY00110 CTCAE: E12198 neutropenia AE a neutrophil count abnormal AE that has an outcome of decreased neutrophil count SIDER: NA NCIt: C80520 HPO: HP_0011991 neutrophil percentage increased AE 10052224 SZ, SS, YH a neutrophil percentage abnormal AE that has an outcome of increase in percentage of neutrophils, a type of white blood cell WEB: http://medical-dictionary.thefreedictionary.com/neutrophil nodular regenerative hyperplasia AE 10051081 a hyperplasia AE that has an outcome of liver/biliary system cell overproduction, associated with portal hypertension WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070012/ SZ, SS, YH non-small cell lung cancer AE 10061873 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004462/ a lung disorder AE that has an outcome of adenocarcinomas in an outer area of the lung, squamous cell carcinomas in the center of the lung or large cell carcinomas in any part of the lung non-small cell lung cancer stage iv AE 10029522 a lung disorder AE that results in the patient suffering from lung cancer at state IV SZ, SS, YH normochromic normocytic anemia AE 10029783 normochromic normocytic anaemia AE SZ, SS, YH SIDER: C0271899 WEB: http://medical-dictionary.thefreedictionary.com/normocytic+normochromic+anemia HPO: HP_0001897 an anemia AE that has an outcome of insufficient numbers of red blood cells despite a normal concentration of hemoglobin in the cells obesity surgery 10059610 SZ, SS, YH a surgery that aims to control obesity obstructive airways disorder AE 10061877 a respiratory system AE that has an outcome of chronic bronchitis or emphysema which causes the airways to narrow over time HPO: HP_0006536 WEB: http://www.medicinenet.com/chronic_obstructive_pulmonary_disease_copd/article.htm SIDER: C0600260 SZ, SS, YH occult blood AE 10061878 WEB: http://dictionary.reference.com/browse/occult+blood a gastrointestinal investigation result abnormal AE that results in blood that is present in amounts too small to be seen and can be detected only by chemical analysis or microscopic examination SZ, SS, YH, EB WEB: http://medical-dictionary.thefreedictionary.com/occult+blood\ odynophagia AE 10030094 a gustatory system AE that has an outcome of painful swallowing in the mouth or esophagus. Can lead to weight loss. WEB: http://medical-dictionary.thefreedictionary.com/odynophagia SZ, SS, YH esophageal pain AE 10015388 10030180 SZ, SS, YH CTCAE: E10661 HPO: HP_0010833 SIDER: C0221727 WEB: http://medical-dictionary.thefreedictionary.com/oesophageal oesophageal pain AE a pain AE located in the esophagus NCIt: C78280 esophageal stenosis AE 10015448 10030194 an esophagus AE that results in a narrowing in the esophagus caused by buildup of scar tissue or by a congenital defect WEB: http://esophagealstenosis.org/ SZ, SS, YH oesophageal stenosis AE CTCAE: E10670 SIDER: C0014866 NCIt: C34595 HPO: HP_0010450 esophagitis AE 10015461 10030216 oesophagitis AE NCIt: C9224 HPO: HP_0100633 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/ CTCAE: E10687 SIDER: C0014868 SZ, SS, YH an esophagus AE located in the esophagus, can present with heartburn, and nausea oligohydramnios AE 10030289 SIDER: C0079924 a reproductive system AE that has an outcome of insufficient placenta, the baby may get less oxygen and nutrients WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002455/ HPO: HP_0001562 SZ, SS, YH placental dysfunction AE onychalgia AE 10064251 SZ, SS, YH a nail disorder AE that has an outcome of pain in the fingernails or toenails WEB: http://dictionary.reference.com/browse/onychalgia onychoclasis AE 10048886 a nail disorder AE that results in the breaking of the fingernails or toenails WEB: http://medical-dictionary.thefreedictionary.com/onychoclasis SIDER: C0546956 SZ, SS, YH HPO: HP_0001808 onycholysis AE 10030337 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/16422468 SIDER: C0085661 a nail disorder AE that results in the nail separating from the nail bed starting at distal or lateral attachment HPO: HP_0008400 evidence establishing an adverse event causal relation Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 33. YH an outcome of adverse event causality evidence that has an outcome of evidence establishes an adverse event causal relation onychomadesis AE 10049274 SZ, SS, YH a nail disorder AE that results in nails spontaneously shedding starting from the proximal end WEB: http://medical-dictionary.thefreedictionary.com/onychomadesis open angle glaucoma AE 10030348 SIDER: C0017612 HPO: HP_0000501 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002587/ SZ, SS, YH Eye disorder AE that results in chronic glaucoma progressing slowly opiates positive AE 10063232 SZ, SS, YH, EB a toxicology drug screen result abnormal AE that results in the patient testing positive for opiates oral candidiasis AE 10030963 SZ, SS, YH WEB: http://www.medicinenet.com/thrush/article.htm thrush AE HPO: HP_0009098 a digestive system AE that has an outcome of a fungal infection located in the mouth caused by the candida fungus SIDER: C0006849 oral cavity fistula AE 10065720 NCIt: C78506 a digestive system AE that has an outcome of fistula, or an abnormal connection between two epithelium-lined organs or vessels, located in the oral cavity CTCAE: E10888 WEB: http://medical-dictionary.thefreedictionary.com/fistula SZ, SS, YH oral herpes AE 10067152 WEB: http://www.emedicinehealth.com/oral_herpes/article_em.htm SZ, SS, YH a digestive system AE that has an outcome of a viral infection located in the mouth caused by herpes simplex virus, causes painful sores oral intake reduced AE SZ, SS, YH a gustatory system AE that has an outcome of a decreased amount of substance in food or drinking water ingested oral mucosa erosion AE 10064594 SZ, SS, YH Digestive System AE that results in oral lesions oral mucosal erythema AE 10067418 SZ, SS, YH an erythema AE that results in redness of the oral mucosa area WEB: http://www.ncbi.nlm.nih.gov/pubmed/17767983 oral pain AE 10031009 SZ, SS, YH NCIt: C78509 WEB: http://medical-dictionary.thefreedictionary.com/oral HPO: HP_0010833 a pain AE located in the oral cavity, pertaining to the mouth SIDER: C0221776 CTCAE: E10904 oral soft tissue disorder AE 10031015 WEB: http://clinicaltrials.gov/show/NCT00001601 a digestive system AE that has an outcome of disease in the soft tissue of the mouth or systemic diseases involving the mouth SZ, SS, YH oral surgery 10051059 SZ, SS, YH a surgery that treats injuries and defects involving both the functional and esthetic aspects of the hard/soft tissue of the head, mouth, teeth, gums, jaws, and neck WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/oral+surgery Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22530364 orbital edema AE 10031051 HPO: HP_0100539 an edema that results in swelling around the eyes orbital oedema AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/7654583 SZ, SS, YH SIDER: C0424813 organizing pneumonia AE 10067472 a pneumonia AE that results in the healing process being characterized by organization and cicatrizaion of the exudate rather than resolution WEB: Primary Source: http://thorax.bmj.com/content/55/4/318.full Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745738/ organising pneumonia AE SZ, SS, YH HPO: HP_0002090 SIDER: C0264383 oropharyngeal candidiasis AE 10050346 Digestive System AE that is characterized by fungus (mainly Candida albicans, but can be other Candida species - C.glabrata, C. tropicalis, C. krusei) in throat or mouth (Thrush) SIDER: C0919659 SZ, SS, YH HPO: HP_0009098 WEB: http://www.cdc.gov/fungal/candidiasis/thrush/ oropharyngeal spasm AE 10031111 a digestive system AE that has an outcome of muscle spasm in the oropharynx area HPO: HP_0003739 SIDER: C0234952 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Oropharyngeal+airway osteomyelitis AE 10031252 SIDER: C0029443 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001473/ HPO: HP_0007626 a bone disorder AE that has an outcome of bacterial infection in the bone osteomyelitis chronic AE 10031256 WEB: Primary Source: http://www.posna.org/education/StudyGuide/chronicOsteomyelitis.asp Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/20471296 SZ, SS, YH a bone disorder AE that has an outcome of chronic infection of the bone or bone marrow adverse event relative risk YH a data item that represents the ratio of the rate of occurence of the adverse event in persons having the medical intervention (e.g., vaccination) to the rate in otherwise comparable persons without the medical intervention. Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20-21. osteonecrosis AE 10031264 SIDER: C0029445 HPO: HP_0010885 a bone disorder AE that has an outcome of bone death due to the loss of blood supply, leading to pain and arthritis SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/osteonecrosis.html osteonecrosis of jaw AE 10064658 WEB: http://www.ncbi.nlm.nih.gov/pubmed/16702591 a bone disorder AE that has an outcome of disease that affects the maxilla and the mandible, characterized through exposure of the bone through lesions in the gingiva that do not heal SZ, SS, YH HPO: HP_0010885 SIDER: C1401381 osteoradionecrosis AE 10067352 a bone disorder AE that has an outcome of necrosis or death of bone as a result of exposure to radiation WEB: http://medical-dictionary.thefreedictionary.com/osteoradionecrosis SZ, SS, YH osteosclerosis AE 10031298 WEB: http://medical-dictionary.thefreedictionary.com/osteosclerosis HPO: HP_0011001 SZ, SS, YH SIDER: C0029464 a bone disorder AE that has an outcome of elevation in bone density ovarian cancer AE 10033128 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001891/ SIDER: C1140680 HPO: HP_0100615 SZ, SS, YH a female reproductive system AE that has an outcome of cancer that starts in the ovaries, female reproductive organs that produce eggs ovarian enlargement AE 10033157 Female reproductive system AE that results in an enlargement of the patient's ovaries SZ, SS, YH ovarian mass AE 10058823 SZ, SS, YH a female reproductive system AE that has an outcome of an abnormal mass appearing in the patient's ovaries overdose AE 10033295 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007287.htm SZ, SS, YH Incorrect dose administration AE that results in the ingestion or application of a drug in greater quantities than recommended oxygen saturation decreased AE 10033318 an oxygen saturation abnormal AE that has an outcome of a decreased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen WEB: Primary Source: http://www.mayoclinic.com/health/hypoxemia/MY00219\ Secondary Source: http://medical-dictionary.thefreedictionary.com/oxygen+saturation SZ, SS, YH, EB pain in jaw AE 10033433 SIDER: C0236000 a pain AE that has an outcome of pain in the set of bones that hold the teeth HPO: HP_0200023 SZ, SS, YH pain of skin AE 10033474 SIDER: C0241136 a pain AE located in the skin SZ, SS, YH, MW CTCAE:E13668 HPO: HP_0010833 NCIt:C78516 palmar erythema AE 10033551 HPO: HP_0007548 WEB: http://www.ncbi.nlm.nih.gov/pubmed/18039017 SIDER: C0014745 SZ, SS, YH a erythema AE that is characterized by the reddening of the palms at the thenar and hypothenar eminences palmar-plantar erythrodysesthesia syndrome AE CTCAE: E13672 YH: MedDRA: 10033553 is for "palmar-plantar erythrodysaesthesia syndrome"; MedDRA: 10054524 is for "palmar-plantar erythrodysesthesia syndrome". Hand Food Syndrome AE WEB: http://news.cancerconnect.com/hand-foot-syndrome-palmar-plantar-erythrodysesthesia/ NCIt: C27177 SZ, SS, YH, MW palmar-plantar erythrodysaesthesia syndrome AE a skin AE generally caused by chemotherapy that is characterized by the palms and soles becoming red, swollen, numb and the skin peeling. UMLS CUI: C0549410 pancreatic mass AE 10049082 Tumor AE that results in an undifferentiated growth in the patient's pancreas WEB: Primary Source: http://stanfordhospital.org/digestivehealth/pancreas/conditions/pancreatic-cysts-symptoms-diagnosis.html Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22855657 SZ, SS, YH pancreatitis acute AE 10033647 SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000287.htm SIDER: C0001339 a pancreatitis AE that has an outcome of sudden inflammation of the pancreas HPO: HP_0001735 pancreatitis relapsing AE 10033657 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002129/ a pancreatitis AE that results in pancreatitis reoccurring in the patient SZ, SS, YH pancytopenia AE 10033661 WEB: http://medical-dictionary.thefreedictionary.com/pancytopenia SIDER: C0030312 SZ, SS, YH HPO: HP_0001876 Hematopoietic System AE that results in a reduction in the amount of red and white blood cells and platelets in blood papilloedema AE 10033703 10033712 SZ, SS, YH an edema AE that has an outcome of optic disc swelling that is caused by increased intracranial pressure HPO: HP_0001085 CTCAE: E10411 papilledema AE WEB: http://medical-dictionary.thefreedictionary.com/Papilloedema SIDER: C0030353 NCIt: C3307 adverse event risk difference The AE risk difference depends on both the background incidence of the adverse event (i.e., among nonrecipients) and the relative risk of its occurence in medical intervention recipients versus nonrecipients. Even when the AE rlative risk is high, the AE risk difference will be low if the event is extremely rare. Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 27. a data item that represents the incidence of the adverse event among recipients of a medical intervention (e.g., vaccinatoin) minus the incidence of the adverse event among otherwise similar nonrecipients. YH parathyroid tumor benign AE 10033964 parathyroid tumour benign AE SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001188.htm Tumor AE that results in a benign tumor in the parathyroid region paronychia AE 10034016 SZ, SS, YH, MW a skin infection AE thar occurs around the fingernails and toenailsnail. Bacteria or a type of yeast called Candida cause this infection. Bacteria and yeast can even combine into one infection. nail infection AE WEB: http://www.healthline.com/health/paronychia HPO: HP_0001818 SIDER: C0030578 WEB: https://en.wikipedia.org/wiki/Paronychia pathological fracture AE 10034156 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/pathological+fracture SIDER: C0016663 HPO: HP_0005744 a bone disorder AE that has an outcome of a broken bone caused by disease leading to weakenss of the bone, commonly osteoporosis pericardial effusion AE 10034474 CTCAE: E10172 HPO: HP_0001698 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110902/ NCIt: C3319 SIDER: C0031039 a cardiac disorder AE that has an outcome of abnormal accumulation of fluid in the pericardial cavity SZ, SS, YH perineal pain AE 10061339 CTCAE:E13175 a pain AE that results in soreness around the vaginal opening after giving birth SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmed/20002420 NCIt:C78529 periodontal disease AE 10034536 CTCAE: E10935 牙龈炎 SIDER: C0031090 SZ, SS, YH NCIt: C63743 a digestive system AE that has an outcome of inflammation and infection that destroys the tissues that support the teeth, including the gums, the periodontal ligaments and the tooth sockets HPO: HP_0000704 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002051/ gingivitis AE periodontitis AE 10034539 HPO: HP_0000704 SZ, SS, YH SIDER: C0031099 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002054/ a bone disorder AE that has an outcome of inflammation and infection of the ligaments and bones that support the teeth peripheral ischemia AE 10034576 10034578 HPO: HP_0002597 CTCAE:E13810 peripheral ischaemia AE SIDER: C0235490 WEB: Primary Source: http://www.medterms.com/script/main/art.asp?articlekey=4052 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/6430442 an ischaemia AE that has an outcome of restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism NCIt: C78535 外周缺血 YH: MedDRA: 10034576 is for "peripheral ischaemia"; MedDRA: 10034578 is for "peripheral ischemia". SZ, SS, YH peripheral motor neuropathy AE 10034580 a motor neuropathy AE that results in damage to the nerves outside of the brain and spinal cord SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001619/ NCIt:C3500 SIDER: C0235025 CTCAE:E12762 HPO: HP_0007178 peripheral sensorimotor neuropathy AE 10056673 Neuropathy can affect nerves that provide feeling (sensory neuropathy) or cause movement (motor neuropathy). It can also affect both, in which case it is called a sensorimotor neuropathy. SZ, SS, YH a peripheral sensory neuropathy AE that results in the patient losing the ability to move or feel. WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000750.htm peripheral sensory neuropathy AE 10034620 WEB: http://medical-dictionary.thefreedictionary.com/Peripheral+sensory+neuropathy SIDER: C0151313 a sensory neuropathy AE that has an outcome of damaged nerves outside the brain and spinal cord HPO: HP_0000763 SZ, SS, YH, MW NCIt:C3501 CTCAE:E12768 peritonsillar abscess AE 10034686 SZ, SS, YH HPO: HP_0001739 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001981/ SIDER: C0031157 an abscess AE that results in a collection of infected material around the tonsils pertussis AE 10034738 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002528/ SZ, SS, YH Respiratory system AE characterized by the whooping cough petechiae AE 10034754 a hemorrhage AE that has an outcome of tiny pinpoint red dots that form due to broken blood vessels under the skin SZ, SS, YH HPO: HP_0000967 MP: MP_0008816 SIDER: C0031256 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm pharyngeal inflammation AE 10065716 WEB: http://www.ncbi.nlm.nih.gov/pubmed/11172144 SZ, SS, YH Inflammation AE that results in an inflammation of the pharyngeal region phlebitis superficial AE 10034902 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Thrombophlebitis Secondary Source: http://emedicine.medscape.com/article/463256-overview a phlebitis that is characterized by blood clots that occur in different locations SZ, SS, YH photodermatosis AE 10051246 SIDER: C0920193 HPO: HP_0000992 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/photodermatosis Secondary Source http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063367/ SZ, SS, YH a skin AE that results in the patient's skin becoming diseased due to exposure to sunlight photosensitivity reaction AE 10034966 10034972 a skin AE that shows a cutaneous disease as a result of sun allergy and may be induced by different triggers such as a chemical. WEB: http://emedicine.medscape.com/article/1049648-overview NCIt: C38004 photosensitivity AE SIDER: C0162830 SZ, SS, YH, MW CTCAE: E13680 MedDRA: 10034972 and UMLS CUI: C0162830 are for "photosensitivity reaction"; MedDRA: 10034966 and UMLS CUI: C0349506 are for "photosensitivity". UMLS CUI: C0349506; UMLS CUI: C0162830 HPO: HP_0000992 WEB: http://www.merckmanuals.com/home/skin-disorders/sunlight-and-skin-damage/photosensitivity-reactions pigmentation disorder AE 10062080 HPO: HP_0001000 a skin AE that has an outcome of loss or reduction in human skin color, may be related to loss of melanocytes or inability of melanocytes to produce melanin SZ, SS, YH SIDER: C0549567 WEB: http://www.nlm.nih.gov/medlineplus/skinpigmentationdisorders.html atrioventricular block AE 10003671 SIDER: C0004245 HPO: HP_0001678 WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 heart block SS AV block a conduction system disorder AE that refers to partial or complete block of electrical impulses originating in the atrium or sinus node, preventing them from reaching the AV node and ventricles pleural effusion AE 10035598 a respiratory system AE that has an outcome of fluid buildup between the layers of tissue that line the lungs and chest cavity CTCAE:E13486 SIDER: C0032227 SZ, SS, YH, MW HPO: HP_0002202 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001150/ NCIt:C3331 pleural hemorrhage AE 10035601 10055319 MedDRA: 10035601 is for "pleural haemorrhage"; MedDRA: 10055319 is for "pleural hemorrhage". UMLS CUI: C0019123 SZ, SS, YH a hemorrhage AE that has an outcome of bleeding in the pleural cavity, the potential space between the two pleura of the lungs CTCAE: E13492 WEB: http://medical-dictionary.thefreedictionary.com/hemothorax NCIt: C50582 pleural haemorrhage AE pleurisy AE 10035618 SZ, SS, YH a lung disorder AE that has an outcome of inflammation of the lining of the lungs and chest that leads to chest pain WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002347/ HPO: HP_0002102 SIDER: C0032231 pleuritic pain AE 10035623 SZ, SS, YH, MW a pain AE induced by inflammation in the lungs that is characterized by sharp or stabbing pain in the chest WEB: http://pleuriticchestpain.net/, http://medical-dictionary.thefreedictionary.com/Pleuritic+chest+pain CTCAE:E13498 NCIt:C78564 pneumatosis intestinalis AE 10057030 a gastrointestinal disorder AE that results in gas cysts developing within the walls of the small or large intestine WEB: http://www.ncbi.nlm.nih.gov/pubmed/9530294 SZ, SS, YH pneumocystis jiroveci pneumonia AE 10064108 a pneumonia AE that has an outcome of a fungal infection of the lungs by Pneumocystis jiroveci WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001692/ HPO: HP_0002096 SIDER: C1535939 SZ, SS, YH pneumomediastinum AE 10050184 Respiratory System AE that results in air being present in the mediastinum SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001148/ pneumonia aspiration AE 10035669 SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000121.htm SIDER: C0032290 a pneumonia AE that has an outcome of inflammation in the lungs and airways to the lungs from breathing in foreign material HPO: HP_0002100 pneumonia primary atypical AE 10035730 WEB: http://medical-dictionary.thefreedictionary.com/primary+atypical+pneumonia SZ, SS, YH a pneumonia AE that has an outcome of an acute systemic disease with involvement of the lungs, caused by Mycoplasma pneumoniAE and marked by high fever and cough pneumonitis AE 10035742 CTCAE:E13502 NCIt:C3333 pulmonitis AE WEB: http://medical-dictionary.thefreedictionary.com/pneumonitis SZ, SS, YH, MW a lung inflammation AE located in the lung tissue pneumothorax AE 10035759 CTCAE:E13508 SZ, SS, YH, MW NCIt:C38006 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001151/ HPO: HP_0006522 SIDER: C0032326 a lung disorder AE that has an outcome of a collapsed lung due to collection of air in the space around the lungs. pollakiuria AE 10036018 a urinary system AE that results in abnormally frequent urination polyuria AE frequent micturition AE HPO: HP_0000103 SIDER: C0042023 SZ, SS, YH WEB: http://www.merriam-webster.com/medical/pollakiuria polycythemia vera AE 10036057 WEB: http://medical-dictionary.thefreedictionary.com/Polycythaemia+vera polycythaemia vera AE SZ, SS, YH a hematopoietic disorder AE that results in the bone marrow producing too many red blood cells portal hypertension AE 10036200 http://www.merriam-webster.com/medlineplus/portal%20hypertension SZ, SS, YH CTCAE: E11238 SIDER: C0020541 WEB: http://www.ncbi.nlm.nih.gov/pubmed/21129318 a hypertension AE located in the heptatic portal system caused by obstruction or occlusion that produces splenomegaly and ascites in its later stages NCIt: C3119 HPO: HP_0001409 portal vein thrombosis AE 10036206 PVT CTCAE: E11243 NCIt: C78565 a thrombosis AE that has an outcome of formation of a blood clot affecting the hepatic portal vein, can lead to hypertension or reduction of blood supply to the liver SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/portal+vein+thrombosis post lumbar puncture syndrome AE 10060854 SZ, SS, YH a syndrome that results in the patient suffering a set of problems after having a spinal tap procedure WEB: http://www.ncbi.nlm.nih.gov/pubmed/19921503 postoperative fever AE 10050087 Fever AE that results in a fever occurring after an operation WEB: http://www.ncbi.nlm.nih.gov/pubmed/22774619 SZ, SS, YH postoperative thrombosis AE 10050902 A thrombosis AE that occurs after an operation that results in a blood clot in a blood vessel disrupting blood flow throughout the body SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/19756494 pregnancy on contraceptive AE 10067667 SZ, SS, YH Female reproductive system AE that results in the patient getting pregnant even when using a contraceptive premature baby AE 10036590 a perinatal AE that has an outcome of premature baby SZ, SS, YH premature labor AE 10036600 SZ, SS, YH a pregnancy AE that has an outcome of labor beginning prior to the 37th week of gestation preterm labor AE WEB: http://wordnetweb.princeton.edu/perl/webwn?s=premature%20labor premature labour AE presyncope AE 10036653 SZ, SS, YH, MW WEB: http://medical-dictionary.thefreedictionary.com/presyncope NCIt:C80100 SIDER: C0700200 a sensory capability AE that has an outcome of a near-fainting episode which may include lightheadedness, dizziness, severe weakness, blurred vision, which may precede syncopal episode CTCAE:E12778 HPO: HP_0002321 primary sequestrum AE 10052460 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/primary+sequestrum a bone disorder AE that has an outcome of a piece of dead bone that completely separates from sound bone during the process of necrosis prinzmetal angina AE 10036759 coronary vessel spasm AE WEB: http://medical-dictionary.thefreedictionary.com/prinzmetal+angina Prinzmetal's angina AE SIDER: C0002963 HPO: HP_0001681 SZ, SS, YH a coronary artery disorder AE that results in cardiac pain at rest that occurs in cycles proctalgia AE 10036772 SZ, SS, YH SIDER: C0034886 WEB: http://medical-dictionary.thefreedictionary.com/proctalgia HPO: HP_0004378 a digestive system AE that results in the pain located at the anus or in the rectum endodontic procedure 10051085 WEB: http://medical-dictionary.thefreedictionary.com/endodontic A medical intervention that is a procedure occuring in the inside structures of the tooth, including the dental pulp and tooth root, and the periapical tissue surrounding the root. YH, SS endotracheal intubation 10067450 WEB: http://medical-dictionary.thefreedictionary.com/Endotracheal+intubation YH, SS A medical intervention that creates a passage of a tube through the nose or mouth into the trachea for maintenance of the airway, as during the administration of anesthesia. gastrectomy 10061965 A surgery that has an outcome of the removal of part or all of the stomach. WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002945.htm YH, SS productive cough AE 10036790 SZ, SS, YH, MW CTCAE:E13517 WEB: http://coldflu.about.com/od/glossary/g/productivecough.htm NCIt:C78569 a cough AE that has an outcome of secretions that could be mucous or blood prostate cancer AE 10060862 SZ, SS, YH HPO: HP_0012125 a tumor AE that has an outcome of cancer that starts in the prostate gland, the small structure that wraps around the urethra carrying urine out of the body SIDER: C0376358 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/ prostate examination abnormal AE 10055025 a physical examination result abnormal AE that results in a prostate exam being different than expected SZ, SS, EB prostatic specific antigen increased AE 10036975 SZ, SS, YH a male reproductive system AE that has an outcome of an increased amount of prostatic specific antigen, a glycoprotein enzyme present in small quantities in the serum of men with healthy prostates. May indicate prostate cancer or prostate disorders WEB: http://www.ncbi.nlm.nih.gov/pubmed/23277770 protein total abnormal AE 10037012 a protein and chemistry analysis result abnormal AE that is characterized by the protein level in the body being abnormal SZ, SS, YH, EB prothrombin level decreased AE 10037050 SZ, SS, YH, EB a prothrombin level abnormal AE that is characterized by a decrease in level of prothrombin in body WEB: http://medical-dictionary.thefreedictionary.com/prothrombin prothrombin time prolonged AE 10037063 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003652.htm SZ, SS, YH, EB a prothrombin time abnormal AE that has an outcome of prolonged time for plasma in the blood to clot pseudomembranous colitis AE 10037128 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001305/ SIDER: C1257843 a digestive system AE that has an outcome of infection in the large intestine with an overgrowth of Clostridium difficile bacteria HPO: HP_0002583 pseudomonas infection AE 10061471 WEB: http://emedicine.medscape.com/article/970904-overview SIDER: C0033817 a bacterial infection AE that has an outcome of infection by genus Pseudomonas, typically targets respiratory tract HPO: HP_0005429 SZ, SS, YH psychosomatic disease AE 10049587 SZ, SS, YH a psychiatric disorder AE that results in physical pain being caused by the patient's life stresses WEB: http://medical-dictionary.thefreedictionary.com/psychosomatic+disease psychotic disorder AE 10061920 A mental disorder AE that results in abnormal condition of the mind HPO: HP_0000709 WEB: http://medical-dictionary.thefreedictionary.com/psychotic+disorder SIDER: C0033975 SZ, SS, YH evidence of biological plausity of adverse event causality an adverse event causality evidence that has an outcome of biological plausity. YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. pulmonary arterial hypertension AE 10064911 SZ, SS, YH HPO: HP_0002092 SIDER: C2973725 a lung disorder AE that has an outcome of hypertension or abnormally high blood pressure in the arteries of the lungs WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/ pulmonary congestion AE 10037368 SIDER: C0242073 a lung disorder AE that has an outcome of engorgement of pulmonary vessels with transudation of fluid into the alveolar and interstitial spaces, seen in cardiac disease, infections, and certain injuries WEB: http://medical-dictionary.thefreedictionary.com/pulmonary+congestion HPO: HP_0004930 SZ, SS, YH pulmonary embolism AE 10037340 10037377 10037437 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299609 HPO: HP_0002204 SZ, SS, YH SIDER: C0034065 an arterial embolism AE that results in the blockage of the main artery of a lung or one of its branches by a substance that has travelled from elsewhere in the body through the bloodstream pulmonary thrombosis AE pulmonary artery thrombosis AE [SS] moved by relation 'SubclassOf' from lung disorder AE to arterial embolism on 01/07/14 pulmonary fibrosis AE 10037383 SZ, SS, YH, MW SIDER: C0034069 HPO: HP_0002206 CTCAE:E13527 NCIt:C26869 a lung disorder AE wih the outcome of damaged or scarred lung tissue. Thickened tissue impairs lung function WEB: http://www.mayoclinic.com/health/pulmonary-fibrosis/DS00927 pulmonary hemorrhage AE 10037394 SZ, SS, YH a lung disorder AE that has an outcome of acute bleeding from the lung, especially in the upper respiratory tract and the endotracheal tube pulmonary haemorrhage AE WEB: http://www.ncbi.nlm.nih.gov/pubmed/23217914 pulmonary hypertension AE 10037400 SIDER: C0020542 NCIt:C3120 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/ CTCAE:E13539 a lung disorder AE that has an outcome of abnormally high blood pressure in the arteris of the lungs SZ, SS, YH, MW HPO: HP_0002092 pulmonary mass AE 10056342 a lung disorder AE that has an outcome of an abnormal spot in the lungs that is more than 3 cm in size SZ, SS, YH WEB: http://lungcancer.about.com/od/whatislungcancer/a/Lung-Mass.htm pulmonary edema AE a lung disorder AE that has an outcome of edema or abnormal buildup of fluid in the air sacs of the lungs, leads to shortness of breath HPO: HP_0100598 SIDER: C0034063 UMLS CUI: C0034063 SZ, SS, YH, MW WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001195/ NCIt: C26868 MedDRA: 10037423 is for "pulmonary oedema"; MedDRA: 10037375 is for "pulmonary edema" pulmonary oedema AE CTCAE: E13521 pulse absent AE 10037469 SZ, SS, YH a cardiovascular disorder AE that has an outcome of an inability to detect pulse WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003078.htm pulse pressure decreased AE 10037480 a cardiovascular disorder AE that has an outcome of abnormally low pulse pressure, less than 25% of systolic value. Can indicate blood loss or low stroke volume WEB: http://medical-dictionary.thefreedictionary.com/pulse+pressure SZ, SS, YH purulent discharge AE 10037569 WEB: http://www.medterms.com/script/main/art.asp?articlekey=21858 SZ, SS, YH an adverse event with an outcome of the release or secretion of pus pyelocaliectasis AE 10061927 SZ, SS, YH a kidney disorder AE that is characterized by the dilation of calices, usually due to obstruction or infection WEB: http://medical-dictionary.thefreedictionary.com/calicectasis radiation injury AE 10037760 SZ, SS, YH an injury AE caused by ionizing radiation WEB: http://medical-dictionary.thefreedictionary.com/Radiation+Injuries radiation mucositis AE 10037763 a digestive system AE that results in the inflammation of mucous membranes lining the digestive tract. Caused by radiation, can lead to mouth sores WEB: http://www.medterms.com/script/main/art.asp?articlekey=19881 SZ, SS, YH radiation esophagitis AE 10048899 radiation oesophagitis AE WEB: http://medical-dictionary.thefreedictionary.com/esophagitis SZ, SS, YH a digestive system AE that has an outcome of inflammation that radiation causes swelling of the esophagus radiation pneumonitis AE 10037765 SZ, SS, YH WEB: http://www.medterms.com/script/main/art.asp?articlekey=8091 a lung inflammation AE due to radiation therapy radiation skin injury AE 10063562 NCIt: C3349 SZ, SS, YH a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation WEB: http://www.bt.cdc.gov/radiation/criphysicianfactsheet.asp rales AE 10037833 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/crackles a respiratory system AE that has an outcome of clicking, rattling or crackling noises made by one or both lungs during inhalation Crackles erythematous rash AE 10037855 SIDER: C0234913 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23145421 rash erythematous AE a rash ae adverse event that results in redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin SZ, SS, YH HPO: HP_0007432 generalized rash AE 10037858 HPO: HP_0000988 rash (generalized) AE SIDER: C0497365 SZ, SS, YH WEB: http://www.freemd.com/rash-generalized/overview.htm a rash AE occuring in several areas of the body rash generalised AE rash pruritic AE 10037884 a rash AE that has an outcome of an unpleasant sensation of the skin that provokes the uge to scratch WEB: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/pruritus-itch/ SZ, SS, YH recall phenomenon AE 10060856 WEB: http://www.ncbi.nlm.nih.gov/pubmed/7577597 SZ, SS, YH an inflammation AE that has an outcome of an inflammatory reaction limited to a previously X-irradiated field when the patient is treated months/years later with certain drugs rectal hemorrhage AE 10038063 10038064 NCIt: C27054 HPO: HP_0002573 rectal haemorrhage AE SIDER: C0267596 SZ, SS, YH CTCAE: E10955 Digestive System AE that results in bleeding in the rectal area red blood cell count decreased AE 10038153 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003644.htm SIDER: C0427457 SZ, SS, YH, EB a red blood cell count abnormal AE that has an outcome of a decrease in red blood cells HPO: HP_0001903 reflux gastritis AE 10057969 SZ, SS, YH a digestive system disorder AE that results in the inflammation of the stomach lining due to reflux WEB: http://medical-dictionary.thefreedictionary.com/gastritis reflux esophagitis AE 10038263 reflux oesophagitis AE HPO: HP_0100633 SZ, SS, YH SIDER: C0014869 WEB: http://medical-dictionary.thefreedictionary.com/esophagitis a digestive system AE located in the esophagus, can present with heartburn, and nausea, caused by gastroesophageal reflux disease renal failure AE 10038435 renal insufficiency AE WEB: http://medical-dictionary.thefreedictionary.com/renal+failure SIDER: C0035078 kidney failure AE HPO: HP_0000083 a kidney disorder AE that results in kidneys failing to adequately filter toxins and waste from the blood SZ, SS, YH acute kidney injury AE 10038436 10069339 NCIt:C26808 As shown on the renal.org website (http://www.renal.org/guidelines/modules/acute-kidney-injury), Acute kidney injury (AKI) has now replaced the term acute renal failure. renal failure acute AE CTCAE:E12973 SZ, SS, YH, Izabela Birsanescu, MW SIDER: C0022660 AKI Acute kidney failure occurs when kidneys become unable to filter waste products from blood. HPO: HP_0001919 WEB: http://www.mayoclinic.org/diseases-conditions/kidney-failure/basics/definition/con-20024029 WEB: http://medical-dictionary.thefreedictionary.com/acute+renal+failure a kidney disorder AE that results in the rapid loss or decline of kidney function renal impairment AE 10062237 a kidney disorder AE that results in the kidneys failing to adequately filter toxins and waste from the blood HPO: HP_0000082 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23263712 SIDER: C0341697 SZ, SS, YH renal tubular atrophy AE 10038536 WEB: http://medical-dictionary.thefreedictionary.com/nephron SZ, SS, YH kidney disorder AE that results in the renal tubule wasting away and losing strength/functional abilities renal vessel disorder AE 10038553 a kidney disorder AE that results in the renal artery narrowing SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/renal+artery+stenosis respiratory disorder AE 10038683 SZ, SS, YH Respiratory system AE that is characterized by conditions that affect organs and systems that deal with gas exchange HPO: HP_0002086 SIDER: C0035204 WEB: http://www.thefreedictionary.com/respiratory+disorder respiratory acidosis AE 10038695 NCIt:C26872 respiratory failure AE a respiratory system AE that has an outcome of a condition where lungs cannot remove all the carbon dioxide the body produces, makes body fluid too acidic SIDER: C1145670 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001154/ SZ, SS, YH CTCAE:E13545 HPO: HP_0004877 respiratory rate increased AE 10038712 SZ, SS, YH WEB: http://www.thefreedictionary.com/tachypnea a respiratory system AE that has an outcome of a ventilory rate greater than 20 breaths per minute respiratory tract hemorrhage AE 10038727 respiratory tract haemorrhage AE SZ, SS, YH Respiratory System AE that results in bleeding somewhere in the respiratory system WEB: http://www.ncbi.nlm.nih.gov/pubmed/8692086 respiratory tract infection AE 10062352 SZ, SS, YH SIDER: C0035243 an infection AE that has an outcome of infection in the respiratory tract, includes pneumonia as well as lung abscess and acute bronchitis WEB: http://www.thefreedictionary.com/respiratory+tract+infection HPO: HP_0002873 retinal hemorrhage AE 10038867 HPO: HP_0000573 retinal haemorrhage AE SZ, SS, YH SIDER: C0035317 WEB: http://medical-dictionary.thefreedictionary.com/retinal+hemorrhage an eye disorder AE that has an outcome of bleeding in the eye retinal pigment epithelial tear AE 10062971 Eye Disorder AE that results in a tearing of retinal pigment epithelial tissue SZ, SS, YH retrograde amnesia AE 10038965 HPO: HP_0002354 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/retrograde+amnesia SIDER: C0002624 Amnesia AE that results in the patient forgeting things that happened before the onset of an injury or disease reversible posterior leukoencephalopathy syndrome AE 10063761 SZ, SS, YH, MW an encephalopathy AE that is characterized by headache, confusion, seizures and visual loss, tends to resolve over time NCIt:C78598 CTCAE:E12798 rhabdomyolysis AE 10039020 SZ, SS, YH SIDER: C0035410 a muscle adverse event that results in damaged skeletal muscle tissue breaks down rapidly HPO: HP_0009045 WEB: http://medical-dictionary.thefreedictionary.com/rhabdomyolysis right ventricular failure AE 10039163 SIDER: C2939447 a right ventricular dysfunction AE that has an outcome of congestive heart failure manifested by distention of the neck veins, enlargement of the liver, and dependent edema WEB: http://medical-dictionary.thefreedictionary.com/right+ventricular+failure SZ, SS, YH HPO: HP_0001708 ruptured ectopic pregnancy AE 10048407 A pregnancy AE that results in the growing pregnancy in a woman's fallopian tube becoming larger than the tube and causing it to rupture WEB: http://www.freemd.com/ruptured-ectopic-pregnancy/overview.htm SZ, SS, YH salivary gland disorder AE 10061935 an abnormal salivary gland physiology AE that results in the salivary glands becoming irritated and/or swollen SIDER: C0036093 HPO: HP_0010286 SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/salivaryglanddisorders.html scab AE 10039509 HPO: HP_0007564 SIDER: C0205204 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/scab a skin AE that has an outcome of a hard coating formed during the wound healing reconstruction phase sciatic nerve injury AE 10039670 SZ, SS, YH a nervous system AE that results in the sciatic nerve losing its sensory capabilities WEB: http://www.ncbi.nlm.nih.gov/pubmed/21995439 scleral hyperemia AE 10052130 SZ, SS, YH an eye disorder AE that is characterized by an excessive accumulation of blood in the eye scleral hyperaemia AE WEB: http://medical-dictionary.thefreedictionary.com/hyperaemia senile dementia AE 10039966 SZ, SS, YH a dementia AE that results in an elderly patient suffering from dementia sensation of blood flow AE 10039996 a sensory capability AE that results in the patient feeling their blood flow SZ, SS, YH septic shock AE 10040070 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001689/ SIDER: C0036983 SZ, SS, YH a shock AE that has an outcome of life-threatening low blood pressure HPO: HP_0002718 sequestrectomy 10053437 a surgery that leads to the excision of a sequestrum, or a piece of dead bone that has become separated during the process of necrosis WEB: http://medical-dictionary.thefreedictionary.com/sequestrectomy SZ, SS, YH shift to the left AE 10056383 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/shift Blood cell lab test abnormal AE showing an increase in the number of immature leukocytes in peripheral blood. (in hematology) a predominance of immature leukocytes noted in a differential white blood cell count. It is usually indicative of an infection or inflammation. The term derives from a graph of blood components in which immature cell frequencies appear on the left side of the graph. shock hemorrhagic AE 10049771 WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+shock shock haemorrhagic AE a physiological shock AE that has an outcome of hypovolemic shock resulting from acute hemorrhage and characterized by hypotension, tachycardia, oliguria, and by pale, cold and clammy skin SZ, SS, YH sigmoiditis AE 10052058 WEB: http://medical-dictionary.thefreedictionary.com/sigmoiditis SZ, SS, YH a gastrointestinal disorder AE that results in the sigmoid colon being inflamed sinus disorder AE 10062244 CTCAE:E13560 SZ, SS, YH, MW NCIt:C26843 WEB: http://medical-dictionary.thefreedictionary.com/paranasal+sinuses a respiratory system AE that has an outcome of disease in the air-filled spaces that surround the nasal cavity, above the eyes and behind the ethmoids sinus tachycardia AE 10040752 a tachycardia AE that has an outcome of elevated impulses originating from the sinoatrial node, greater than 100 bpm NCIt: C26889 CTCAE: E10214 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sinus+tachycardia SIDER: C0039239 HPO: HP_0001649 skin chapped AE 10040813 a skin AE that is characterized by sore, cracked, or rough skin, usually on the hands, face and lips. SZ, SS, YH WEB: http://wellbeing.doctissimo.com/wellbeing-a-z/chapped-skin.html skin fissures AE 10040849 SZ, SS, YH a skin AE that results in linear-like cleavages in the skin WEB: http://medical-dictionary.thefreedictionary.com/fissure skin hemorrhage AE 10064265 skin haemorrhage AE a skin AE that has an outcome of bleeding at the skin SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm SIDER: C0852361 HPO: HP_0000967 skin hyperpigmentation AE 10040865 HPO: HP_0010284 SIDER: C0162834 CTCAE:E13718 SZ, SS, YH, MW a skin AE that has an outcome of darkening in an area of skin or nails caused by increased melanin WEB: http://medical-dictionary.thefreedictionary.com/hyperpigmentation NCIt:C79731 skin infection AE 10040872 NCIt: C35025 WEB: http://medical-dictionary.thefreedictionary.com/skin+infection CTCAE: E11568 a skin AE that has an outcome of infection. Can be bacterial, fungal, parasitic or viral SZ, SS, YH HPO: HP_0001581 SIDER: C0037278 skin laceration AE 10058818 WEB: http://www.mdguidelines.com/lacerations a skin AE that has an outcome of a jagged wound, can be shallow cuts or deep gahes that penetrate through muscle to internal organs and bone SZ, SS, YH skin lesion AE 10040882 HPO: HP_0011355 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Skin+Lesions SIDER: C0037284 a skin AE that has an outcome of a superficial growth or patch of the skin that does not resemble the area surrounding it skin reaction AE 10040914 a skin AE that has an outcome of exposure of skin to nonspecific irritants or from the action of specific allergens SZ, SS, YH WEB: http://encyclopedia2.thefreedictionary.com/Skin+Reactions skin toxicity AE 10059516 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/dermal+toxicity a skin AE that has an outcome of irritation, sensitization and phototoxicity sleep disorder AE 10040984 SIDER: C0851578 a behavior and neurological AE that results in irregular sleep patterns SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sleep+disorder HPO: HP_0002360 sleep-related eating disorder AE 10067315 an eating disorder AE that is characterized by patient searching for food while asleep WEB: http://www.ncbi.nlm.nih.gov/pubmed/23205019 SZ, SS, YH small intestinal obstruction AE 10041101 WEB: http://www.mayoclinic.com/health/intestinal-obstruction/DS00823 HPO: HP_0005214 a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the small intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors CTCAE: E11021 NCIt: C78615 SZ, SS, YH SIDER: C0235329 small intestinal resection 10041105 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002943.htm a surgery that is characterized by all of or part of the small intestine needing to be removed SZ, SS, YH small intestinal stenosis AE 10062263 WEB: http://medical-dictionary.thefreedictionary.com/stenosis SZ, SS, YH a gastrointestinal disorder AE in which the blood vessels in the small intestine narrow NCIt: C78617 CTCAE: E11032 small intestine carcinoma AE 10054184 WEB: http://medical-dictionary.thefreedictionary.com/small+intestine+cancer a tumor AE that results in cancer in the small intestine SZ, SS, YH small intestine ulcer AE 10041133 SZ, SS, YH a gastrointestinal disorder AE that results in an ulcer in the patient's small intestine CTCAE: E11038 NCIt: C78619 soft tissue infection AE 10062255 SIDER: C0149778 HPO: HP_0002719 NCIt: C79745 WEB: http://www.reference.md/files/D018/mD018461.html SZ, SS, YH CTCAE: E11579 a connective tissue disorder AE that occurs in the non-skeletal tissue, usually subcutaneous and muscle tissue soft tissue injury AE 10041291 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/22964676 a connective tissue disorder AE that results in damage to muscles, ligaments, and tendons throughout the body soft tissue necrosis AE 10065769 a necrosis AE that results in necrosis occurring in soft tissue SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/necrosis somatoform disorder AE 10054153 SZ, SS, YH a behavior and neurological AE that results in the patient hvings a mental disorder with symptoms that may suggest physical illness or injury WEB: http://medical-dictionary.thefreedictionary.com/somatoform+disorder spinal compression fracture AE 10041541 a bone disorder AE that has an outcome of vertebra collapse caused by small hairline fractures WEB: http://www.webmd.com/osteoporosis/guide/spinal-compression-fractures-causes SZ, SS, YH spinal cord compression AE 10041549 SIDER: C0037926 a nervious system AE that has an outcome of spinal cord compressed by bone fragments from a vertebral fracture, a tumor, abscess, ruptured intervertebral disc or other lesion WEB: http://medical-dictionary.thefreedictionary.com/spinal+cord+compression HPO: HP_0002176 SZ, SS, YH spinal cord neoplasm AE 10062261 SZ, SS, YH Tumor AE that results in a tumor in the patient's spinal cord spinal osteoarthritis AE 10041591 HPO: HP_0002758 WEB: http://www.webmd.com/osteoarthritis/guide/spinal-osteoarthritis-degenerative-arthritis-of-the-spine Spinal osteoarthritis AE is a osteoarthritis AE that has an outcome of degeneration of the protective cartilage that cushions the tops of bones, causes swelling and pain and may cause development of osteophytes. SZ, SS, YH SIDER: C0949690 splenomegaly AE 10041660 SIDER: C0038002 SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003276.htm an immune system disorder AE that has an outcome of a larger-than-normal spleen, affects blood filtration HPO: HP_0001744 sputum culture positive AE 10051612 SZ, SS, YH, EB a microbiology and serology investigation result abnormal AE that has an outcome of bacterial infection in the lungs or breathing passages WEB: http://www.webmd.com/lung/sputum-culture sputum increased AE 10041812 a respiratory system AE that shows increased sputum, which results in mucous material coughed up from the lungs by the patient. WEB: http://www.medterms.com/script/main/art.asp?articlekey=5539 SZ, SS, YH SIDER: C0235567 HPO: HP_0002105 squamous cell carcinoma AE 10041823 HPO: HP_0006739 SIDER: C0007137 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001832/ a skin AE that has an outcome of a type of nonmelanoma skin cancer SZ, SS, YH staphylococcal infection AE 10058080 HPO: HP_0007499 SZ, SS, YH a bacterial infection AE that has an outcome of invasion by Staphylococcus, can present with pus, fever, chills and low blood pressure WEB: http://www.medicinenet.com/staph_infection/page2.htm SIDER: C0038160 stasis dermatitis AE 10041955 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000834.htm SZ, SS, YH a skin AE that results in the skin in the leg undergoing discoloration due to blood pooling as a result of insufficient venous return stent occlusion AE 10049936 SZ, SS, YH a device occlusion AE that has an outcome of blockage of the stent, or a tube inserted into body to prevent or counteract a disease-induced, localized flow constriction WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002303.htm stevens-johnson syndrome AE 10042033 HPO: HP_0000951 SIDER: C0038325 SZ, SS, YH, MW a skin adverse event that is characterized by cell death causing the epidermis to separate from the dermis WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001854/ CTCAE:E13736 NCIt:C79484 stress at work AE 10042210 a stress AE that results in patient experiencing stress at work SZ, SS, YH adverse event causality evidence from case report an adverse event causality evidence that comes from a case report. Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. YH subarachnoid hemorrhage AE 10042316 subarachnoid haemorrhage AE SIDER: C0038525 a nervous system AE that has an outcome of bleeding in the area between the brain and the thin tissues that cover the brain HPO: HP_0002138 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001720/ SZ, SS, YH subdural hematoma AE 10042361 HPO: HP_0100309 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001732/ a nervous system AE that has an outcome of a collection of blood on the surface of the brain SIDER: C0018946 subdural haematoma AE gastric hemorrhage AE 10017788 10017789 gastric haemorrhage AE YH, SS NCIt: C54582 A gastrointestinal hemorrhage AE that has an outcome of the bleeding in the stomach CTCAE: E10706 sudden death AE 10042434 10042435 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/sudden+death HPO: HP_0001645 SIDER: C0011071 CTCAE: E11171 a death AE that has an outcome of unexpected death, 1 to 24 hours after the onset of symptoms NCIt: C50911 suicidal ideation AE 10042458 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Suicidal+ideation Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/10193592 SZ, SS, YH, MW a psychiatric disorder AE that results in thoughts about suicide CTCAE:E12964 NCIt:C80102 suicide attempt AE 10042464 HPO: HP_0000708 a psychiatric disorder AE that results in attempted suicide NCIt:C80111 CTCAE:E12969 SZ, SS, YH, MW SIDER: C0038663 superinfection AE 10042566 a viral infection AE that has an outcome of a cell that was previously infected being coinfected with a different strain of the virus SZ, SS, YH HPO: HP_0005364 WEB: http://medical-dictionary.thefreedictionary.com/superinfection SIDER: C0038826 superior sagittal sinus thrombosis AE 10042567 a venous thrombosis AE in which a stroke occurs as a result of thrombosis. uncommon cerebrovascular accident that is frequently associated with diseases that may contribute to the development of thrombosis through hypercoagulability, stasis of the local blood stream, and abnormalities of the vessel wall. SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/1455986 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1026412 SSST supraventricular extrasystoles AE 10042602 SIDER: C0033036 an arrhythmia AE that has an outcome of premature atrial contractions or beats caused by signals originating from ectopic atrial sites WEB: http://sideeffects.embl.de/se/C0033036/ SZ, SS, YH HPO: HP_0005115 supraventricular tachycardia AE 10042604 SIDER: C0039240 NCIt: C35061 a tachycardia AE that has an outcome of rapid heart rhythm originating at or above the atrioventricular node HPO: HP_0004765 CTCAE: E10218 WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001235/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23233691 SZ, SS, YH suspiciousness AE 10042635 SZ, SS, YH Adverse event that is characterized by the patient becoming increasingly suspicious suture related complication AE 10059059 WEB: http://www.ncbi.nlm.nih.gov/pubmed/17276274 an injury and procedural complication AE that results in a complication resulting from a suture SZ, SS, YH suture rupture AE 10048547 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21266279 a surgery AE that results in a suture being used to hold body tissues together, ruptures tachyarrhythmia AE 10049447 HPO: HP_0001649 an increased heartbeat AE that is characterized by a distburance of the heart rhythm in which heart rate is abnormally increased WEB: http://medical-dictionary.thefreedictionary.com/tachyarrhythmia SZ, SS, YH SIDER: C0080203 tachycardia paroxysmal AE 10043079 SZ, SS, YH WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/11208235 Secondary Source: http://www.nlm.nih.gov/medlineplus/ency/article/000183.htm a tachycardia AE that results in tachycardia beginings and ending in an acute manner tachypnea AE 10043089 tachypnoea AE SIDER: C0231835 an abnormal repiration AE that shows an outcome of tachypnoea (i.e., abnormally rapid breathing or respiration) HPO: HP_0004346 SZ, SS, YH adverse event causality evidence from case series YH an adverse event causality evidence that comes from the study of a case report series. Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. temporal lobe epilepsy AE 10043209 Behavior and neurological AE that results in the patient having recurring seizures WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001714/ SZ, SS, YH graft versus host disease AE 10018651 An immune system disorder AE that is a complication that can occur after a stem or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm YH, SS GVHD thrombocythemia AE 10015493 a hematopoietic system AE that has an outcome of too many blood platelets or thrombocytes, can result in headache, lightheadedness, vision changes and limb numbness WEB: http://www.mayoclinic.com/health/thrombocythemia/DS01087 thrombocythaemia AE SZ, SS, YH thrombocytopenia AE 10043554 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000586.htm a hematopoietic system AE that has an outcome of decrease in platelets in the blood HPO: HP_0001873 SZ, SS, YH SIDER: C0040034 thrombophlebitis AE 10043570 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001108.htm SZ, SS, YH SIDER: C0040046 HPO: HP_0004418 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002098/ a phlebitis AE located in the vein, caused by a blood clot thrombotic microangiopathy AE 10043645 SZ, SS, YH SIDER: C2717961 HPO: HP_0002597 WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583 WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/18215115 Secondary Source: http://www.nejm.org/doi/full/10.1056/NEJMra020528 a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion thyroid adenoma AE 10043688 HPO: HP_0000854 SZ, SS, YH a tumor AE that results in a benign tumor in the thyroid SIDER: C0151468 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004524/ thyroid mass AE 10058900 a tumor AE that results in the patient hvings a mass growing in their thyroid SZ, SS, YH heart rate irregular AE 10019304 an arrhythmia AE that has an outcome of an irregular rate of the heartbeat SIDER: C0237314 HPO: HP_0011675 YH, SS tobacco withdrawal symptoms AE 10059612 a syndrome AE that results in the patient suffering from withdrawal from not using tobacco SZ, SS, YH tongue ulceration AE 10043991 SZ, SS, YH a tongue AE that has an outcome of open sores or cuts on the tongue HPO: HP_0000155 SIDER: C0235351 WEB: http://www.localhealth.com/article/tongue-ulcers tonsil cancer AE 10044002 Tumor AE that results in cancer in the patient's tonsils SZ, SS, YH tooth abscess AE 10044016 a bone disorder AE that has an outcome of an abscess located in the tooth or a bacterial infection in the center of a tooth SIDER: C0518988 SZ, SS, YH HPO: HP_0000164 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002055/ tooth disorder AE 10044034 SIDER: C0040435 a bone disorder AE that has an outcome of disease in the teeth SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/toothdisorders.html HPO: HP_0000164 tooth fracture AE 10062544 WEB: http://medical-dictionary.thefreedictionary.com/tooth+fracture a bone disorder AE that has an outcome of a break or rupture in a bone SZ, SS, YH tooth loss AE 10044044 HPO: HP_0006349 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23253824 a bone disorder AE that has an outcome of one or more teeth coming loose and falling out SZ, SS, YH SIDER: C0080233 toothache AE 10044055 odontalgia AE HPO: HP_0000164 a bone disorder AE that has an outcome of an aching pain in or around a tooth CTCAE: E11054 SZ, SS, YH WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/toothache Seconday Source: http://www.ncbi.nlm.nih.gov/pubmed/22157099 NCIt: C78640 SIDER: C0040460 toxic nodular goitre AE 10044242 SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000317.htm a endocrine system AE that has an outcome of an excess production of thryoid hormone, characterized by functionally autonomous nodules hepatic function abnormal AE A liver AE that has an outcome of an abnormal functionality of the liver YH, SS SIDER: C0086565 HPO: HP_0001410 tracheitis AE 10044302 10066798 SZ, SS, YH NCIt: C78647 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001983/ a respiratory system AE that results in the trachea being infected by a bacteria CTCAE: E11599 tracheobronchitis AE 10044314 WEB: http://medical-dictionary.thefreedictionary.com/tracheobronchitis a respiratory system AE that is characterized by the inflammation of the muscous membranes of the trachea and bronchi SIDER: C0040586 HPO: HP_0002837 SZ, SS, YH trance AE 10044334 SZ, SS, YH a behavior and neurological AEthat results in the patient being in a state of trance WEB: http://medical-dictionary.thefreedictionary.com/trance transaminase level increased AE 10054889 a transaminase level abnormal AE that has an outcome of elevated levels of alanine transaminase and aspartate transaminase SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/Transaminases hypertrophic cardiomyopathy AE 10020871 HPO: HP_0001639 YH, SS A cardiomyopathy AE that has an outcome of a condition in which the heart muscle becomes thick. Often, only one part of the heart is thicker than the other parts. The thickening can make it harder for blood to leave the heart, forcing the heart to work harder to pump blood. It also can make it harder for the heart to relax and fill with blood. HCM SIDER: C0007194 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001243/ transposition of the great vessels AE 10044443 a vascular disorder AE that results in an abnormal spatial arrangement of any of the primary blood vessels WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002535/ SZ, SS, YH hyperchloremia AE 10020599 UMLS CUI: C0085679 a blood chloride abnormal AE that is characterized by an abnormally high level of chloride in the blood YH, MW tricuspid valve incompetence AE 10044640 a cardiac valve disease AE that is characterized by a tricuspid valve that does not close tightly enough to prevent leakage WEB: http://medical-dictionary.thefreedictionary.com/Tricuspid+Valve+Insufficiency SZ, SS, YH tri-iodothyronine decreased AE 10044594 SZ, SS, YH, EB a tri-iodothyronine level abnormal AE that results in a decreased level of tri-iodothyronine WEB: http://medical-dictionary.thefreedictionary.com/Tri-iodothyronine troponin level increased AE 10058267 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007452.htm a troponin level abnormal AE that has an outcome of an increased amount of troponin, a protein released when the heart muscle is damaged SZ, SS, YH, EB tuberculosis AE 10044755 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001141/ a bacterial infection AE that is caused by M. tuberculosis. SZ, SS, YH tumour excision 10061392 SZ, SS, YH a surgery that removes a tumour WEB: http://medical-dictionary.thefreedictionary.com/Tumor+Removal tumor flare AE 10045169 Tumor AE that results in a tumor reoccurring tumour flare AE SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/21523725 tumour hemorrhage AE 10049750 tumour haemorrhage AE an hemorrhage AE that has an outcome of bleeding in the tumour SZ, SS, YH WEB: http://calder.med.miami.edu/pointis/tbifam/cause3.html tumor lysis syndrome AE 10045152 10045170 NCIt: C3425 WEB: http://www.ncbi.nlm.nih.gov/pubmed/15384972 CTCAE: E12365 a syndrome AE that has an outcome of a group of metabolic complications that can occur after treatment of cancer tumour lysis syndrome AE SZ, SS, YH tumor marker increased AE 10048621 WEB: http://www.cancer.gov/cancertopics/factsheet/detection/tumor-markers tumour marker increased AE a cytogenetic investigation result abnormal AE that has an outcome of an increase in a substance found in the blood, urine, or body tissues that can be elevated in cancer, among other tissue types SZ, SS, YH, EB tumor necrosis AE 10054094 a necrosis AE that has an outcome of death of tumor tissue, tumor rapidly outgrows its blood supply tumour necrosis AE WEB: http://medical-dictionary.thefreedictionary.com/tumor+necrosis SZ, SS, YH ulcerative keratitis AE 10064996 WEB: http://medical-dictionary.thefreedictionary.com/Ulcerative+keratitis a keratitis AE that has an outcome of disrupted epithelial layer and stroma of the cornea, may become blind SZ, SS, YH HPO: HP_0007812 corneal ulcer AE SIDER: C0010043 ultrafiltration failure AE 10069568 Homeostasis AE that results in an inability to achieve adequate fluid balance SZ, SS, YH upper airway obstruction AE 10067775 Respiratory system AE that is characterized by the patient having an obstruction in their upper airway SZ, SS, YH SIDER: C0740852 HPO: HP_0002781 upper gastrointestinal hemorrhage AE 10046274 10055356 SIDER: C0041909 HPO: HP_0002239 SZ, SS, YH upper gastrointestinal haemorrhage AE NCIt: C78660 WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/gastrointestinal+bleeding Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1237869/ CTCAE: E11062 a gastrointestinal hemorrhage AE that has an outcome of bleeding in the upper gastrointestinal tract ureteric obstruction AE 10046406 a urinary system AE that has an outcome of a blockage in the urinary tract, can result in pain, fever, infection, loss of kidney function, sepsis or death if severe SIDER: C0041956 WEB: http://www.mayoclinic.org/ureteral-obstruction/ SZ, SS, YH HPO: HP_0006000 urethral obstruction AE 10046459 Urinary system AE that results in the urethra becoming obstructed SZ, SS, YH HPO: HP_0000796 SIDER: C0041972 urethral stenosis AE 10065584 SZ, SS, YH Urinary System AE that results in the urethra becoming narrowed at the external meatus WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urethral+meatal+stenosis Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22710090 urge incontinence AE 10046494 HPO: HP_0000012 SIDER: C0150045 SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002250/ a urinary incontinence AE that results in the patient feeling a sudden urgency or need to urinate. urinary retention AE 10046555 HPO: HP_0000016 Urinary system AE that results in an inability to urinate CTCAE:E13046 SIDER: C0080274 SZ, SS, YH, MW WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urinary+retention Secondary Source: http://www.medtronic.com/patients/urinary-retention/index.htm NCIt:C50790 urinary tract infection pseudomonal AE 10062279 SZ, SS, YH a urinary tract infection AE that results in the infection of the urinary tract by the Pseudomonas Aeruginosa organism WEB: http://www.jiph.org/article/S1876-0341(09)00058-6/abstract urinary tract infection staphylococcal AE 10062280 a urinary tract infection AE that results in the urinary tract being infected with the staphylococcal bacteria SZ, SS, YH urine amphetamine positive AE 10051400 SZ, SS, YH, EB a toxicology drug screen result abnormal AE that results in a positive result for amphetamines in the urine urine output decreased AE 10059895 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003147.htm NCIt: C80522 a urine abnormality AE that has an outcome of decreased urine output, less than 500 milliliters of urine in 24 hours CTCAE: E12217 SZ, SS, YH urosepsis AE 10048709 a urinary system AE caused by an infection in the urinary tract that has an outcome of accumulation of pus-forming bacteria or toxins in the blood of the urinary tract. SZ, SS, YH WEB: http://www.primehealthchannel.com/urosepsis-definition-symptoms-causes-diagnosis-and-treatment.html urticaria papular AE 10046750 SZ, SS, YH WEB: http://medical-dictionary.thefreedictionary.com/papular+urticaria an urticaria AE that results in the appearance of "wheals" on skin uterine contractions during pregnancy AE 10049975 a uterine AE that results in uterine contractions during pregnancy SZ, SS, YH uterine hemorrhage AE 10046788 10046789 NCIt: C78686 CTCAE: E13237 SZ, SS, YH, MW uterine haemorrhage AE HPO: HP_0000130 a uterine AE that has an outcome of bleeding from the uterus MedDRA: 10046788 is for "uterine haemorrhage"; MedDRA: 10046789 is for "uterine hemorrhage" SIDER: C0042134 uterine hypertonus AE 10046790 HPO: HP_0000130 a uterine AE that results in the patient undergoing a single uterine contraction for over two minutes during pregnancy WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488 SZ, SS, YH SIDER: C0269842 vaginal infection AE 10046914 SZ, SS, YH CTCAE: E11624 NCIt: C26911 SIDER: C0404521 HPO: HP_0000142 an infection AE that results in infection of the vagina varices esophageal AE 10056091 a digestive system AE that has an outcome of dilated sub-mucosal veins in the lower third of the esophagus WEB: http://www.mayoclinic.com/health/esophageal-varices/DS00820 HPO: HP_0002040 varices oesophageal AE SIDER: C0014867 SZ, SS, YH vascular dementia AE 10057678 a dementia AE that results in problems with reasoning, judgement, and memory resulting from brain damage from impaired blood flow to the brain SZ, SS, YH WEB: http://www.mayoclinic.com/health/vascular-dementia/DS00934 vein discoloration AE 10047183 a vascular disorder AE that results in the veins becoming discoloured vein discolouration AE SZ, SS, YH vena cava thrombosis AE 10047193 10047195 WEB: http://emedicine.medscape.com/article/1933035-overview, http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm vena cava embolism AE a thrombosis AE that has an outcome of a blood clot in the inferior vena cava SZ, SS, YH venous injury AE 10047228 NCIt: C78711 SZ, SS, YH CTCAE: E12051 a vascular disorder AE that results in an injury to the vein(s) venous thrombosis AE 10047249 a thrombosis AE that has an outcome of a blood clot that forms within a vein HPO: HP_0004850 SZ, SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm SIDER: C0042487 ventricular dysfunction AE 10059056 SZ, SS, YH a cardiac ventricular disorder AE that has an outcome of an abnormality in the contraction of the ventricles or the motion of the cells WEB: http://medical-dictionary.thefreedictionary.com/ventricular+dysfunction adverse event causality evidence from uncontrolled observational study an adverse event causality evidence that comes from an uncontrolled observational study YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. vestibular neuronitis AE 10047393 an ear disorder that results in irritation and swelling (inflammation) of the inner ear lybyrinthitis AE SZ, SS, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002049/ vision blurred AE 10005886 10047513 an abnormal vision AE that results in unclear vision blurred vision AE NCIt: C27123 WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003029.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23111613 HPO: HP_0000622 SIDER: C0344232 CTCAE: E10346 SZ, SS, YH visual acuity reduced AE 10047531 SIDER: C0234632 HPO: HP_0000572 SZ, SS, YH an abnormal vision AE that results in a decrease in clearness of vision WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003396.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23329671 visual brightness AE 10049155 an abnormal vision AE that results in the patient suffering from an enhanced brightness in their vision SZ, SS, YH vitamin d deficiency AE 10047626 HPO: HP_0100513 a gustatory system AE that has an outcome of a shortage of vitamin D which is essential for strong bones WEB: http://www.webmd.com/diet/vitamin-d-deficiency SZ, SS, YH SIDER: C0042870 adverse event causality evidence from controlled observational study YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 29. an adverse event causality evidence that comes from controlled observational studies. vitritis AE 10047663 Inflammation AE that is characterized by an inflammatory reaction of the vitreous or hyaloid membrane as a result of disease in adjacent structures WEB: http://medical-dictionary.thefreedictionary.com/vitritis SZ, SS, YH weight increased AE 10047896 10047899 CTCAE: E12224 SZ, SS, YH NCIt: C62754 a physical examination result abnormal AE that shows an increase (gain) in weight of a patient SIDER: C0043094 weight gain AE HPO: HP_0004324 wolff-parkinson-white syndrome AE 10048015 CTCAE: E10244 NCIt: C35132 SZ, SS, YH a conduction system disorder AE that results in an abnormal accessory electrical conduction pathway between the atria and ventricles WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001206/ wound complication AE 10053692 SZ, SS, YH WEB: https://en.wikipedia.org/wiki/Wound CTCAE: E12057 a wound AE that has an outcome of complication to the wound NCIt: C78719 wound dehiscence AE 10048031 NCIt: C50863 WEB: http://medical-dictionary.thefreedictionary.com/wound+dehiscence a wound AE that has an outcome of a wound breaking open along the surgical sutures SZ, SS, YH CTCAE: E12063 wound secretion AE 10048629 WEB: http://www.ncbi.nlm.nih.gov/pubmed/2815962 SZ, SS, YH A wound AE that has an outcome of secretions or pus produced by damaged tissue particles and repairing mechanisms intitiated by the body xanthopsia AE 10048216 SIDER: C0221185 SZ, SS, YH HPO: HP_0000551 an abnormal vision AEthat results in the patient seeing a predominance of yellow in their vision WEB: http://medical-dictionary.thefreedictionary.com/xanthopsia zygomycosis AE 10061418 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001672/ SZ, SS, YH an immune system disorder AE that results in a fungal infection of the sinuses, brain, or lungs that occurs in some people with a weakened immune system ischemic cardiomyopathy AE 10048858 A cardiomyopathy AE that has an outcome of a heart failure with left ventricular dilatation resulting from ischemic heart disease. ischaemic cardiomyopathy AE WEB: http://medical-dictionary.thefreedictionary.com/ischemic+cardiomyopathy YH, SS jaw operation 10059242 YH, SS A surgery that is a procedure performed on the jaw narcolepsy AE http://en.wikipedia.org/wiki/Narcolepsy An adverse event that is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally. YL YL mechanical ventilation 10067221 A medical intervention that is a life-support system designed to replace or support normal ventilatory lung function YH, SS WEB: www.medscape.com/resource/mechanical-ventilation mucosal inflammation AE 10028116 10028130 NCIt: C26887 An inflammation AE that has an outcome of tissue swelling and other inflammatory response in the mouth oral mucositis CTCAE: E10872 YH, SS multi-organ failure AE 10028154 YH, SS A systematic adverse event that has an outcome of failure in mulitple organs CTCAE: E11155 NCIt: C75568 pleomorphic rash AE 多形性皮疹 JX, LW, YH Pleomorphic rash AE is rash AE that is a rash characterized by many-formed. osteoporosis AE 10031282 SIDER: C0029456 WEB: http://www.mayoclinic.com/health/osteoporosis/DS00128 NCIt:C3298 HPO: HP_0000939 YH, SS, MW A bone disorder AE that has an outcome of the weakening or brittle bone CTCAE:E12508 Mendelian susceptibility to mycobacterial disease http://www.ncbi.nlm.nih.gov/pubmed/20718793 A groupd of disroders where the genetic susceptibility plays an important role to the seletctive susceptibility to poorly pathogenic mycobacterial species such as bacille Calmette-Guérin and environmental mycobacteria. MSMD YL restrictive cardiomyopathy AE 10038748 CTCAE: E10192 NCIt: C62798 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000189.htm YH, SS infiltrative cardiomyopathy A cardiomyopathy AE that has an outcome of a condition that the heart cannot relax normally during the time between heartbeats when the blood returns from the body (diastole). stem cell transplant 10063581 YH, SS A medical intervention that has an outcome of the transplant of stem cells into the body adverse event causality evidence from controlled clinical trial In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention. an adverse event causality evidence that comes from a controlled clincal trial YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30. stent placement 10048561 YH, SS A medical intervention that has an outcome of an intersion of a tube into the body stress cardiomyopathy AE 10066286 A cardiomyopathy AE that is a temporary heart condition brought on by stressful situations, such as the death of a loved one. People with broken heart syndrome may have sudden chest pain or think they're having a heart attack. These broken heart syndrome symptoms may be brought on by the heart's reaction to a surge of stress hormones. In broken heart syndrome, a part of your heart temporarily enlarges and doesn't pump well, while the remainder of the heart functions normally or with even more forceful contractions. YH, SS takotsubo cardiomyopathy, broken heart syndrome, stress-induced cardiomyopathy, apical ballooning syndrome WEB: http://www.mayoclinic.com/health/broken-heart-syndrome/DS01135/METHOD=print tooth extraction 10062132 YH, SS A medical intervention that has an outcome of an extraction of the tooth toxic skin eruption AE 10057970 dermatitis medicamentosa, dermatosis medicamentosa, drug rash YH, SS A skin adverse event that has an outcome of an eruption caused by ingestion, injection, inhalation, or insertion of a drug, often a result of allergic sensitization. Also called dermatitis medicamentosa, dermatosis medicamentosa, drug rash WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption ventricular fibrillation AE 10047290 SIDER: C0042510 NCIt: C50799 YH, SS CTCAE: E10236 VF HPO: HP_0001663 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004467/ An arrythmia AE that has an outcome of a severely abnormal heart rhythm (arrhythmia) that can be life-threatening. first degree atrioventricular block AE 10003674 CTCAE: E10098 NCIt: C62015 SS first degree heart block atrioventricular block first degree an atrioventricular block AE that there is some prolongation of AV conduction time (PR interval). The heart's electrical signals are slowed as they move from the atria to the ventricles (the heart's upper and lower chambers, respectively). This results in a longer, flatter line between the P and the R waves on the EKG (electrocardiogram). WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html wound debridement 10048030 YH, SS surgical debridement, enzymatic debridement, autolytic debridement, mechanical debridement A medical intervention that has an outcome of the removal of dead, damaged, dying or infected tissue. The human body is capable of (autolytic) debridement for small wounds, but for large wounds, medical procedures are necessary. WEB: http://surgery.about.com/od/glossaryofsurgicalterms/g/Debridement.htm subacute thyroiditis AE http://emedicine.medscape.com/article/125648-overview A thyroiditis AE that shows a self-limited thyroid condition associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function. silent thyroiditis AE https://en.wikipedia.org/wiki/Subacute_lymphocytic_thyroiditis painless thyroiditis AE YL, YH SAT macrophagic myofasciitis AE http://www.ncbi.nlm.nih.gov/pubmed/14593574 YL MMF YL Macrophagic myofasciitis (MMF) is a rare inflammatory muscle disorder characterized by a characteristic infiltration of muscle tissue by PAS-positive macrophages, which is caused by pathological persistence of vaccine-derived aluminium hydroxide. The diagnosis can only be established by an open muscle biopsy from the muscle that was used for intramuscular vaccination. disseminated BCG infection AE YL BCG infection following BCG injection. It is often related with the vaccinee's immunodeficiency. YL autism AE http://en.wikipedia.org/wiki/Autism An adverse event that is a disorder of neural development characterized by impaired social interaction and communication, and by restricted and repetitive behavior. HPO: HP_0000717 SIDER: C0004352 YL autoimmune encephalitis AE YL Autoimmune Encephalitis may be triggered by infection in which case the term "Post-infectious Encephalitis" is used. ADEM( Acute Disseminated Encephalomyelitis ) is a Post-infectious Encephalitis. The illness usually follows in the wake of a mild viral infection (such as those that cause rashes in childhood) or immunisations. Typically there is a delay of days to two to three weeks between the triggering infection and development of the encephalitis. It has recently been recognised that there are other types of Autoimmune Encephalitis resulting from an attack of the brain by the body's immune system. Some of these types of autoimmune encephalitis are identified by finding a specific antibody in blood. These conditions include Potassium channel complex antibody associated encephalitis, NMDAR and Hashimoto's encephalitis. http://www.encephalitis.info/information/the-illness/types-of-autoimmune-encephalitis/ an adverse event that is a type of encephalitis triggered by vaccination. injection-site redness AE YH an injection-site AE that display an redness in the injection-site injection-site tenderness AE 10043224 a sensory capability AE that shows up skin tenderness and occurs in an injection site of a medical intervention YH arm motion limitation AE YH a movement disorder AE that has an outcome of arm motion limitation injection-site muscular soreness AE 10028332 a sensory capability AE that shows up muscular soreness at the injection site of a medical intervention YH sleepiness AE 10041014 YH a sleep disorder AE that shows up sleepiness (Sluggish from sleep, inactive, quiet). brain AE YH an adverse event that occurs in brain. brain disorder AE mild hypersensitivity AE YH a hypersensitivity AE that is mild. injection-site arm edema AE an injection-site edema AE that occurs in the arm. YH restlessness AE 10038743 a psychiatric disorder AE that shows restlessness NCIt:C74533 YH, MW UMLS_CUI: C0085631 CTCAE:E12960 WEB: http://dictionary.reference.com/browse/restlessness induration with tenderness AE a sensory capability AE that results in a sensation of induration with tenderness. YH fussiness AE YH a sensory capability AE that results in a sensation of fussiness decreased sleep AE YH a sleep disorder AE that shows decreased sleep increased sleep AE a sleep disorder AE that shows increased sleep YH joint pain AE YH a pain AE that occurs at a joint tiredness AE 10043890 This term appears to be a synonym to the 'fatigue AE'. Tiredness AE is a sensory capability AE that results in a sensation of tiredness. hypodynamia AE 疲劳/乏力 JX, LW, YH nasal discomfort AE YH nasal discomfort AE is a respiratory system AE that shows a discomfort from the nose HPO: HP_0010640 SIDER: C0858259 adverse event causality P-value an adverse event causal associate score that represents a statatical P-value to address the causal adverse event hypothesis. YH proportional reporting ratio YH WEB: http://www.ncbi.nlm.nih.gov/pubmed/11828828 The PRR will typically be calculated using a surveillance database in which reports of adverse events from a variety of drugs are recorded. PRR a data item that represents a statistic to summarize the extent to which a particular adverse event is observed for individuals taking a specific medical intervention (e.g., a drug), compared to the frequency at which the same adverse event occurs for patients taking some other intervention (e.g., other drug or any drug in a specified class of drugs). P-value of adverse event causality Chi-square test an adverse event causality P-value that is calculated out of a specific Chi-square test. YH adverse event filtering cutoff YH a data item that represents a threshold cutoff for filtering out those adverse event case reports that are unlikely important for a specific AE study. This is applied to the analysis of AE case resport data in an AE case reporting system such as FAERS or VAERS. WEB: http://www.ncbi.nlm.nih.gov/pubmed/23209624 AE prevalence rate AG, YH A data item that is defined as the number of patients realized with an adverse event beginning in an interval or continuing from a previous interval divided by the number of patients taking the same medical intervention within that interval. The prevalence thus indicates the number of events that began and persisted over time. WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf nuclear magnetic resonance imaging result abnormal AE 10029816 EB an imaging investigation result abnormal AE that is indicated by an abnormal result of a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body computerized tomogram with contrast abnormal AE a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body using a dye, called oral contrast, that shows up on the CT images to help better define internal organs computerised tomogram with contrast abnormal AE EB computerized tomogram without contrast abnormal AE computerised tomogram without contrast abnormal AE EB a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body cardiovascular investigation result abnormal AE 10007512 an investigation result abnormal AE that involves an abnormal result of an investigation involving the cardiovascular system EB, YH second degree atrioventricular block AE 10003677 an atrioventricular block AE that some but not all atrial impulses fail to reach the ventricles, thus some ventricular beats are dropped. Electrical signals between the atria and ventricles are slowed to a large degree. Some signals don't reach the ventricles. On an EKG, the pattern of QRS waves doesn't follow each P wave as it normally would. SS second degree heart block atrioventricular block second degree WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html echocardiogram result abnormal AE 10061593 a cardiac and vascular investigation result abnormal AE that is an abnormal result of a test that uses sound waves to create a moving picture of the heart EB electrolyte lab test abnormal AE 10047843 EB an investigation result abnormal AE that involves an abnormal electrolyte value blood phosphorus abnormal AE 10054823 EB an electrolyte lab test abnormal AE that shows an abnormal blood phosphorus level blood phosphorus increased 10050196 EB, YH, MW SIDER: C0919625 HPO: HP_0002905 A physical quality that has an increased level of phosphate in the blood complete atrioventricular block AE 10003673 third degree heart block SS an atrioventricular block AE that complete atrioventricular dissociation occurs; atria and ventricles beat independently. None of the electrical signals reach the ventricles. This type also is called complete heart block or complete AV block. When complete heart block occurs, special areas in the ventricles may create electrical signals to cause the ventricles to contract. This natural backup system is slower than the normal heart rate and isn't coordinated with the contraction of the atria. On an EKG, the normal pattern is disrupted. The P waves occur at a faster rate that isn't coordinated with the QRS waves. third degree atrioventricular block CTCAE: E10093 WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751 WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html NCIt: C50501 complete heart block atrioventricular block complete blood potassium abnormal AE 10005722 HPO: HP_0011042 SIDER: C0853759 an electrolyte lab test abnormal AE that results in an abnormal level of potassium in the blood EB blood potassium increased 10005725 HPO: HP_0002513 SIDER: C0853760 hyperkalemia AE a physical quality where the blood potassium level is increased. EB, YH, MW blood sodium abnormal AE 10005800 an electrolyte lab test abnormal AE that results in an abnormal level of sodium in the blood EB blood sodium increased 10005803 HPO: HP_0003228 SIDER: C0595878 A physical quality that has an increased level of sodium in the blood EB, YH, MW blood magnesium abnormal AE 10005652 EB an electrolyte lab test abnormal AE that results in an abnormal level of magnesium in the blood blood magnesium increased 10005655 A physical quality that has an increased level of magnesium in the blood EB, YH, MW blood chloride abnormal AE 10005417 an electrolyte lab test abnormal AE that results in an abnormal level of chloride in the blood EB blood chloride increased 10005420 A physical quality that has an increased level of chloride in the blood EB blood calcium abnormal AE 10005393 EB an electrolyte lab test abnormal AE that results in an abnormal level of calcium in the blood blood calcium increased 10005396 EB, YH, MW A physical quality that has an increased level of calcium in the blood urinary system investigation result abnormal AE 10038362 renal and urinary tract investigation and urinalysis result abnormal AE an investigation result abnormal AE that involves the renal and urinary tract and urinalyses EB, YH renal system investigation result abnormal AE blood creatinine level abnormal AE 10005481 a urinary system investigation result abnormal AE that is characterized by an abnormal level of creatinine in the blood EB blood urea level abnormal AE 10005846 EB a urinary system investigation result abnormal AE that is characterized by an abnormal level of urea in the blood lipid analysis result abnormal AE 10024580 EB an investigation result abnormal AE that involves an abnormal result of a lipid analyses blood cholesterol abnormal AE 10005423 EB a lipid analysis result abnormal AE that results in an abnormal blood cholesterol level blood cholesterol decreased AE 10005424 EB a blood cholesterol abnormal AE that results in a decreased amount of cholesterol in the blood high density lipoprotein abnormal AE 10020051 a lipid analysis result abnormal AE that is characterized by an abnormal amount of high density lipoprotein EB high density lipoprotein increased AE 10020061 EB a high density lipoprotein abnormal AE that is characterized by an increased amount of high density lipoprotein high density lipoprotein decreased AE 10020060 SIDER: C0151691 EB a high density lipoprotein abnormal AE that is characterized by a decreased amount of high density lipoprotein HPO: HP_0003233 low density lipoprotein abnormal AE 10024901 a lipid analysis result abnormal AE that is characterized by an abnormal amount of low density lipoprotein EB low density lipoprotein increased AE 10024910 a low density lipoprotein abnormal AE that is characterized by an increased amount of low density lipoprotein EB SIDER: C0549399 HPO: HP_0003141 low density lipoprotein decreased AE 10024909 a low density lipoprotein abnormal AE that is characterized by a decreased amount of low density lipoprotein EB blood triglycerides abnormal AE 10005837 a lipid analysis result abnormal AE that is characterized by an abnormal amount of triglycerides in the blood EB blood triglycerides increased AE 10005839 a blood triglycerides abnormal AE that is characterized by an increased amount of triglycerides in the blood EB HPO: HP_0002155 SIDER: C0853692 blood triglycerides decreased AE 10005838 a blood triglycerides abnormal AE that is characterized by a decreased amount of triglycerides in the blood EB immunology and allergy investigation result abnormal AE 10021505 EB an investigation result abnormal AE that involves an abnormal result for an immunology and allergy investigation Mobitz type I block AE 10027787 10047908 10047909 10050797 Wenckebach's block Mobitz type 1 block type 1 second degree atrioventricular block NCIt: C62017 a second degree atrioventricular block AE that the electrical signals are delayed more and more with each heartbeat, until the heart skips a beat. On the EKG, the delay is shown as a line (called the PR interval) between the P and QRS waves. The line gets longer and longer until the QRS waves don't follow the next P wave. WEB: https://www.nhlbi.nih.gov/health/health-topics/topics/hb/types CTCAE: E10146 Wenckebach Phenomenon SS, MW, YH type I second degree atrioventricular block MedDRA: 10050797 is a LLT for type I second degree atrioventricular block MedDRA (LLT): 10047909 exists for Wenckebach phenomeono MedDRA (LLT): 10047908 exists for Wenchebach MedDRA (LLT): 10027787 for Mobit type I Epstein-Barr virus antibody positive AE 10056906 an immunology and allergy investigation result abnormal AE that is characterized by antibodies for epstein barr virus being detected EB microbiology and serology investigation result abnormal AE 10027529 EB an immunology and allergy investigations result abnormal AE that is characterized by an abnormal microbiology and serology investigation CSF culture positive AE 10011529 a microbiology and serology investigation result abnormal AE that is characterized by a positive CSF culture EB metabolic and nutritional investigation result abnormal AE 10027432 EB an investigation result abnormal AE that involves an abnormal result of a metabolic and nutritional investigation glycosylated hemoglobin level abnormal AE 10055587 a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal glycosylated hemoglobin level EB glycosylated hemoglobin level increased AE 10055587 EB a glycosylated hemoglobin level abnormal AE that is charaterized by an increased glycosylated hemoglobin level blood folate level abnormal AE 10005525 a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood folate level EB blood folate level increased AE 10005528 EB a blood folate abnormal AE that is charaterized by an increased blood folate level blood glucose level abnormal AE 10005554 EB a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood glucose level blood homocysteine level abnormal AE 10049735 a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood homocysteine EB blood homocysteine level decreased AE 10049734 EB a blood homocysteine level abnormal AE that is charaterized by a decreased blood homocysteine blood uric acid level abnormal AE 10061727 EB a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood uric acid level blood uric acid level decreased AE 10005860 EB a blood uric acid level abnormal AE that is characterized by a decreased blood uric acid vitamin B12 level abnormal AE 10062187 EB a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal vitamin B12 level vitamin B12 level increased AE 10047610 a vitamin B12 level abnormal AE that is characterized by an increased vitamin B12 level EB vitamin B12 level decreased AE 10047608 a vitamin B12 level abnormal AE that is characterized by a decreased vitamin B12 level EB brain natriuretic peptide level abnormal AE 10053408 a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal brain natriuretic peptide level EB brain natriuretic peptide level increased AE 10053405 a brain natriuretic peptide level abnormal AE that is characterized by an increased brain natriuretic peptide level EB brain natriuretic peptide level decreased AE 10053407 a brain natriuretic peptide level abnormal AE that is characterized by a decreased brain natriuretic peptide level EB blood gas investigation result abnormal AE 10005539 10027432 EB, SJ blood gases abnormal AE may be a result of lung, kidney, or metablolic diseases or the result of abnormal breathing after a head or neck injur WEB: http://medical-dictionary.thefreedictionary.com/arterial+blood+gas a hematology investigation result abnormal AE that involves an abnormal result of the oxygen and carbon dioxide content of arterial blood, measured by various methods to assess the adequacy of ventilation and oxygenation and the acid-base status of the body WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003855.htm carbon dioxide abnormal AE 10064156 EB WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003469.htm a blood gas investigation result abnormal AE that is characterized by an abnormal amount of carbon dioxide in the blood carbon dioxide increased AE 10007225 a carbon dioxide abnormal AE that is characterized by an increased carbon dioxide level in the blood HPO: HP_0005972 EB SIDER: C0860713 blood pH abnormal AE 10005705 a blood gas investigation result abnormal AE that is characterized by an abnormal acidity or alkalinity of blood WEB: http://www.medterms.com/script/main/art.asp?articlekey=10001 EB blood pH increased AE 10005708 a blood pH abnormal AE that is characterized by an increased blood pH EB blood pH decreased AE 10005706 a blood pH abnormal AE that is characterized by a decreased blood pH EB adverse event causality evidence from combined sources an adverse event causality evidence that comes from the combined evidence sources Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28. YH oxygen saturation abnormal AE 10033317 EB a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen saturation in the blood oxygen saturation increased AE 10033320 an oxygen saturation abnormal AE that is characterized by an increased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen EB PCO2 abnormal AE 10058982 WEB: http://medical-dictionary.thefreedictionary.com/PCO2 a blood gas investigation result abnormal AE that is characterized by an abnormal carbon dioxide partial pressure or tension in the blood EB PCO2 increased AE 10034183 a PCO2 abnormal AE that is characterized by an increased carbon dioxide partial pressure or tension in the blood EB PCO2 decreased AE 10034181 EB a pPCO2 abnormal AE that is characterized by a decreased carbon dioxide partial pressure or tension in the blood PO2 abnormal AE 10062087 WEB: http://medical-dictionary.thefreedictionary.com/PO2 EB a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen partial pressure in the blood PO2 increased AE 10035769 a PO2 abnormal AE that is characterized by an increased oxygen partial pressure in the blood EB PO2 decreased AE 10035768 EB a PO2 abnormal AE that is characterized by a decreased oxygen partial pressure in the blood toxicology drug screen result abnormal AE 10044260 an investigation result abnormal AE that results from an abnormal toxicology screen EB barbiturates positive AE 10063230 EB a toxicology drug screen result abnormal AE that is characterized by positive barbiturates cocaine positive AE 10063230 a toxicology drug screen result abnormal AE that is characterized by positive cocaine EB Mobitz type II block AE 10027786 10050798 type 2 second degree atrioventricular block WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html Mobitz (type) II atrioventricular block AE type II second degree atrioventricular block SS, YH, MW CTCAE: E10140 a second degree atrioventricular block AE that some of the electrical signals don't reach the ventricles. However, the pattern is less regular than it is in Mobitz type I. Some signals move between the atria and ventricles normally, while others are blocked. On an EKG, the QRS wave follows the P wave at a normal speed. Sometimes, though, the QRS wave is missing (when a signal is blocked). Mobitz type 2 block NCIt: C62018 urine cannabinoids increased AE 10062228 a toxicology drug screen result abnormal AE that is characterized by increased urine cannabinoids EB behavioral and neurological test abnormal AE 10029295 an investigation result abnormal AE that involves an abnormal result of a neurological, special senses and psychiatric investigation EB neurological, special senses and psychiatric investigation result abnormal AE physical examination result abnormal AE 10062078 10071940 EB an investigation result abnormal AE resulting from an abnormal physical examination finding cytogenetic investigation result abnormal AE 10011822 EB an investigation result abnormal AE that involves an abnormal result of an investigation related to chromosomal abnormalities and pathologic conditions WEB: http://medical-dictionary.thefreedictionary.com/Cytogenetic+analysis respiratory and pulmonary investigation result abnormal AE 10038668 an investigation result abnormal AE that involves an abnormal respiratory and pulmonary investigation EB endocrine investigation result abnormal AE 10014706 EB an investigation result abnormal AE that involves an abnormal result of an endocrine investigation adverse event causality evidence from randomized clinical trial YH Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30. In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention. an adverse event causality evidence that comes from a randomized controlled clincal trial where a medical intervention is conducted in a random fashion blood parathyroid hormone level abnormal AE 10005700 an endocrine investigation result abnormal AE that is characterized by an abnormal blood parathyroid hormone level EB blood parathyroid hormone increased AE 10005703 a blood parathyroid hormone level abnormal AE that is characterized by an increased blood parathyroid hormone level EB tri-iodothyronine level abnormal AE 10044592 an endocrine investigation result abnormal AE that is characterized by an abnormal tri-iodothyronine level EB tri-iodothyronine increased AE 10044596 EB a tri-iodothyronine level abnormal AE that is characterized by an increased tri-iodothyronine level protein and chemistry analysis result abnormal AE 10037000 EB an investigation result abnormal AE that involves an abnormal protein and chemistry analysis result blood albumin level abnormal AE 10005286 EB a protein and chemistry analysis result abnormal AE that is characterized by an abnormal blood albumin level blood albumin level increased AE 10005288 a blood albumin level abnormal AE that is characterized by an increased blood albumin level EB c-reactive protein level abnormal AE 10068559 EB a protein and chemistry analysis result abnormal AE that is characterized by an abnormal c-reactive protein level c-reactive protein level decreased AE 10049220 EB a c-reactive protein level abnormal AE that is characterized by a decreased c-reactive protein level protein total increased AE 10037016 a protein total abnormal AE that is characterized by an increased protein total EB protein total decreased AE 10037014 EB a protein total abnormal AE that is characterized by a decreased protein total MUGA scan result abnormal AE 10028146 EB a cardiac and vascular investigation result abnormal AE that involves an abnormal result from a test using a radioactive tracer (called a radionuclide) and a special camera to take pictures of your heart as it pumps blood WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Radionuclide-Ventriculography-or-Radionuclide-Angiography-MUGA-Scan_UCM_446354_Article.jsp cardiac stress test result abnormal AE 10055014 EB, YH a cardiac function test abnormal AE that shows an abnormal result on a cardiac stress test. WEB: http://medical-dictionary.thefreedictionary.com/Stress+Test WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures enzyme investigation result abnormal AE 10014938 an investigation result abnormal AE that is characterized by an abnormal result of an enzyme investigation EB blood creatine phosphokinase level decreased AE 10067760 EB a blood creatine phosphokinase level abnormal AE that is characterized by a decreased blood creatine phosphokinase hematology investigation result abnormal AE 10018851 haematology investigation abnormal AE an investigation result abnormal AE that is characterized by an abnormal result of a hematology investigation MedDRA: 10057755 EB red blood cell profile abnormal AE 20000029 EB a hematology investigation result abnormal AE that results in an abnormal red blood cell profile white blood cell profile abnormal AE 20000030 a hematology investigation result abnormal AE that is characterized by an abnormal white blood cell profile EB neutrophil percentage abnormal AE 10058134 EB a white blood cell profile abnormal AE that is characterized by an abnormal percentage of neutrophils neutrophil percentage decreased AE 10052223 a neutrophil percentage abnormal AE that is characterized by a decreased percentage of neutrophils EB basophil count abnormal AE 10060978 a white blood cell profile abnormal AE that is characterized by an abnormal basophil count EB basophil count decreased AE 10004167 a basophil count abnormal AE that is characterized by a decreased basophil count EB eosinophil percentage abnormal AE 10058133 EB a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil percentage eosinophil percentage decreased AE 10052221 EB an eosinophil percentage abnormal AE that is characterized by a decreased eosinophil percentage leukocyte cell number abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal leukocyte cell number EB granulocyte count abnormal AE 10018678 EB a white blood cell profile abnormal AE that is characterized by an abnormal granulocyte count granulocyte count increased AE 10018683 a granulocyte count abnormal AE that is characterized by an increased granulocyte count EB lymphocyte count abnormal AE 10025252 EB a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte cell number lymphocyte percentage abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte percentage EB monocyte percentage abnormal AE 10067238 a white blood cell profile abnormal AE that is characterized by an abnormal monocyte percentage EB monocyte percentage decreased AE 10052229 EB a monoctyte percentage abnormal AE that is characterized by a decreased monocyte percentage blood lactate dehydrogenase level abnormal AE 10005627 EB an enzyme investigation result abnormal AE that is characterized by an abnormal blood lactate dehydrogenase level blood lactate dehydrogenase level decreased AE 10005629 a blood lactate dehydrogenase level abnormal AE that is characterized by a decreased blood lactate dehydrogenase EB troponin level abnormal AE an enzyme investigation result abnormal AE that is characterized by an abnormal troponin level EB muscle enzyme level abnormal AE EB an enzyme investigation result abnormal AE that is characterized by an abnormal muscle enzyme level muscle enzyme level decreased AE 10057952 a muscle enzyme level abnormal AE that is characterized by a decreased muscle enzyme level EB myoglobin blood abnormal AE EB an enzyme investigation result abnormal AE that is characterized by an abnormal myoglobin level in the blood myoglobin blood increased AE 10028625 a myoglobin blood abnormal AE that is characterized by an increased myoglobin level in the blood EB myoglobin blood decreased AE 10059940 a myoglobin blood abnormal AE that is characterized by a decreased myoglobin level in the blood gastrointestinal investigation result abnormal AE 10017971 EB an investigation result abnormal AE that is characterized by an abnormal result of a gastrointestinal investigation blood amylase level abnormal AE 10054822 EB a gastrointestinal investigation result abnormal AE that is characterized by an abnormal blood amylase level blood amylase level decreased AE 10005327 a blood amylase level abnormal AE that is characterized by a decreased blood amylase level EB lipase level abnormal AE 10054821 EB a gastrointestinal investigation result abnormal AE that is characterized by an abnormal lipase level lipase level increased AE 10024574 a lipase level abnormal AE that is characterized by an increased lipase level EB lipase level decreased AE 10024573 EB a lipase level abnormal AE that is characterized by a decreased lipase level liver related investigation result abnormal AE 20000008 EB an investigation result abnormal AE that is characterized by an abnormal liver related investigation result transaminase level abnormal AE 10062688 a liver related investigation result abnormal AE that is characterized by an abnormal level of transaminases EB transaminase level decreased AE 10054795 EB a transaminase level abnormal AE that is characterized by a decreased level of transaminases aspartate aminotransferase level abnormal AE 10003477 EB a liver related investigation result abnormal AE that is characterized by an abnormal aspartate aminotransferase level aspartate aminotransferase level decreased AE 10003479 an aspartate aminotransferase level abnormal AE that is characterized by a decreased aspartate aminotransferase level EB gamma-glutamyltransferase level decreased AE 10017690 a gamma-glutamyltransferase level abnormal AE that is characterized by a decreased gamma-glutamyltransferase level EB blood bilirubin level decreased AE 10049869 EB a blood bilirubin level abnormal AE that is characterized by a decreased blood bilirubin level imaging investigation result abnormal AE 10022893 an investigation result abnormal AE that is characterized by an abnormal result of an imaging investigation EB blood thromboplastin level abnormal AE 10005824 a hematology investigation result abnormal AE that is characterized by an abnormal blood thromboplastin level EB blood thromboplastin level decreased AE 10005826 EB a blood thromboplastin level abnormal AE that is characterized by a decreased blood thromboplastin level coagulation factor v level abnormal AE 10061771 a hematology investigations result abnormal AE that is characterized by an abnormal coagulation factor v level EB coagulation factor v level increased AE 10009756 EB a coagulation factor v level abnormal AE that is characterized by an increased coagulation factor v level prothrombin level abnormal AE 10037048 a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin level EB prothrombin level increased AE 10037051 EB a prothrombin level abnormal AE that is characterized by an increased prothrombin level SIDER: C0151872 HPO: HP_0003645 prothrombin time abnormal AE 10037057 a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin time EB prothrombin time shortened AE 10037070 EB a prothrombin time abnormal AE that is characterized by a shortened prothrombin time full blood count increased AE 10052239 EB a full blood count abnormal AE that is characterized by an increased full blood count red blood cell count abnormal AE 10038151 EB a red blood cell profile abnormal AE that is characterized by an abnormal red blood cell count red blood cell count increased AE 10038155 EB a red blood cell count abnormal AE that is characterized by an increased red blood cell count hematocrit abnormal AE 10057763 a red blood cell profile abnormal AE that is characterized by an abnormal hematocrit EB hematocrit increased AE 10019424 a hematocrit abnormal AE that is characterized by an increased hematocrit EB hemoglobin level increased AE 10055599 CTCAE: E12171 a hemoglobin level abnormal AE that is characterized by an increased hemoglobin level NCIt: C78333 EB mean corpuscular volume abnormal AE 10027009 EB a red blood cell profile abnormal AE that is characterized by an abnormal mean corpuscular volume mean corpuscular volume increased AE 10051859 a mean corpuscular volume abnormal AE that is characterized by an increased mean corpuscular volume EB mean corpuscular volume decreased AE 10051858 EB a mean corpuscular volume abnormal AE that is characterized by a decreased mean corpuscular volume mean cell hemoglobin level abnormal AE EB a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin level mean cell hemoglobin level increased AE 10055622 a mean cell hemoglobin level abnormal AE that is characterized by an increased mean cell hemoglobin level EB mean cell hemoglobin level decreased AE 10055621 a mean cell hemoglobin level abnormal AE that is characterized by a decreased mean cell hemoglobin level EB mean cell hemoglobin concentration abnormal AE 10067730 EB a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin concentration mean cell hemoglobin concentration increased AE 10026992 a mean cell hemoglobin concentration abnormal AE that is characterized by an increased mean cell hemoglobin concentration EB mean cell hemoglobin concentration decreased AE 10026991 a mean cell hemoglobin concentration abnormal AE that is characterized by a decreased mean cell hemoglobin concentration EB sinoatrial node dysfunction AE SND SS a conduction system disorder that refers to abnormalities in SN impulse formation and propagation and includes sinus bradycardia, sinus pause/arrest, chronotropic incompetence, and sinoatrial exit block. WEB: http://emedicine.medscape.com/article/158064-overview sinus node dysfunction coronary disorder AE Even though 'coronary disorder AE' seems to be a more general term of 'coronary artery disorder AE' that should place 'coronary disorder AE' as a parent of 'coronary artery disorder AE', KB's comment from clinical perspective is that these two terms are synonymous in practice, and coronary disorder almost always means coronary artery disorder. If 'coronary disorder AE' gets picked up from reports, it is a generalized term of 'coronary artery disorder AE'; and thereofore, we created a place holder for this term under 'coronary artery disorder AE' SS a coronary artery disorder AE that takes place in or is related to the coronary inside the heart inferior wall myocardial infarction AE WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=inferior+wall+myocardial+infarction SS myocardial infarction, inferior wall AE a myocardial infarction AE in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery. anterior wall myocardial infarction AE WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=anterior+wall+myocardial+infarction a myocardial infarction AE in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction. SS myocardial infarction, anterior wall AE blast cell count abnormal AE EB a hematology investigation result abnormal AE that is characterized by an abnormal blast cell count blast cell count decreased AE 10062275 a blast cell count abnormal AE that is characterized by a decreased blast cell count EB platelet count abnormal AE 10035526 a hematology investigation result abnormal AE that is characterized by an abnormal platelet count EB HPO: HP_0011873 SIDER: C0580317 platelet count increased AE 10051608 SZ, SS, YH, EB a platelet count abnormal AE that is characterized by an increased platelet count WEB: http://medical-dictionary.thefreedictionary.com/thrombocytosis eosinophil count abnormal AE 10061125 EB a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil count eosinophil count decreased AE 10014943 an eosinophil count abnormal AE that is characterized by a decreased eosinophil count EB systemic hypertension AE WEB: http://www.pted.org/?id=syshypertension1 SS a hypertension AE that is characterized by high blood pressure in the systemic arteries - the vessels that carry blood from the heart to the body's tissues (other than the lungs). blood pressure systolic decreased AE 10005758 a hypotension AE that has an outcome of a decrease in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body SIDER: C0277885 HPO: HP_0006673 WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes SS papillary muscle disorder AE 10061330 WEB: http://medical-dictionary.thefreedictionary.com/papillary+muscle+dysfunction a cardiac valve disease AE that is characterized by an impaired function of a papillary muscle, usually due to ischemia or infarction, with resulting incompetence of the mitral (rarely tricuspid) valve. SS papillary muscle syndrome papillary muscle dysfunction blood pressure diastolic increased AE 10005739 HPO: HP_0005117 a hypertension AE that has an outcome of an increase in the amount of pressure in the arteries when the heart is at rest between beats SIDER: C0277889 SS WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers blood pressure systolic increased AE 10005760 SS WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers SIDER: C0277884 HPO: HP_0004421 a hypertension AE that has an outcome of an increase in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body right ventricular dysfunction AE 10058597 NCIt: C50733 a cardiac ventricular disorder AE that is a condition in nwhich the right ventricle of the heart was functionally impaired. This condition usually leads to heart failure or myocardial infarction, and other cardiovascular complicationns. WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=right%20ventricular%20dysfunction SS CTCAE: E10196 ventricular extrasystoles AE 10047289 WEB: http://dictionary.reference.com/browse/ventricular+extrasystole infranodal extrasystoles AE SS an arrhythmia AE that is characterized by a premature contraction of the ventricle HPO: HP_0006696 SIDER: C0151636 cardiac embolism AE SS heart embolism AE an embolism disorder AE that is a result of an obstruction in a cardiac vessel due to a blood clot or other foreign matters WEB: http://medical-dictionary.thefreedictionary.com/Heart+embolism embolism AE 10014523 SIDER: C0013922 HPO: HP_0001907 SS WEB: http://medical-dictionary.thefreedictionary.com/embolism a vascular disorder AE that is characterized by an obstruction in a blood vessel due to a blood clot or other foreign matter that gets stuck while traveling through the bloodstream. 栓塞 retrodictive AE causality retrodictive causality of adverse event YH an adverse event causity that represents a retrodictrive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: given an individual who has received a medical intervention and developed the adverse event, was the event caused by the medical intervention? Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20. premature ventricular contractions AE 10036614 WEB: http://www.mayoclinic.com/health/premature-ventricular-contractions/DS00949 SS PVCs an arrhythmia AE that results in extra, abnormal heartbeats that begin in one of the heart's two lower pumping chambers (ventricles). These extra beats disrupt the regular heart rhythm, sometimes causing the patient to feel a flip-flop or skipped beat in the chest. pulmonary valve incompetence AE 10037448 HPO: HP_0010444 SS a cardiac valve disease AE that is charaterized by the backflow of blood from the pulmonary artery into the right ventricle, owing to imperfect functioning of the pulmonary valve WEB: http://www.rightdiagnosis.com/medical/pulmonary_valve_incompetence.htm pulmonic incompetence AE SIDER: C0034088 pulmonary valve stenosis AE 10037450 WEB: http://medical-dictionary.thefreedictionary.com/Pulmonary+Valve+Stenosis pulmonic stenosis AE a cardiac vavle disease AE that is characterized by a congenital heart defect in which blood flow from the heart to the pulmonary artery is blocked SS arteritis AE 10003230 a vasculitis AE that is an inflammation specific to an artery or arteries SS SIDER: C0003860 HPO: HP_0005291 WEB: http://medical-dictionary.thefreedictionary.com/arteritis severity of adverse event AE severity YH, SS a process quality that represents the level of severity of an adverse event. aneurysm AE 10002329 HPO: HP_0002617 SIDER: C0002940 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001122.htm a vascular disorder AE that results in an abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel SS venous disorder AE SS a vascular disorder that affects the veins or blood circulation of the veins aneurysm ruptured AE 10048380 an aneurysm AE that results in the weakening of the balloon-like bulge that the blood pressure causes the artery wall to leak or burst HPO: HP_0002617 SS SAH subarachnoid hemorrhage AE SIDER: C0162869 ruptured aneurysm AE WEB: http://www.mayfieldclinic.com/PE-AneurRupt.htm#.Uor4tI3QHh0 cardiac aneurysm AE 10007513 heart aneurysm AE SS WEB: http://www.ncbi.nlm.nih.gov/pubmed/19239694 aneurysm of heart AE an aneurysm AE that refers to an aneurysm involving cardiac tissue. This most often occurs as a ventricular aneurysm following a myocardial infarction aortic aneurysm AE 10002882 SIDER: C0003486 HPO: HP_0004942 an aneurysm AE that occurs in the aorta SS WEB: http://www.webmd.com/heart-disease/tc/aortic-aneurysm-overview aortic aneurysm rupture AE 10002886 SS an aneurysm ruptured AE that occurs in the aorta ruptured aortic aneurysm AE SIDER: C0741160 HPO: HP_0002622 aortic dissection AE 10002895 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000181.htm HPO: HP_0004933 SS an aortic disorder AE in which there is a separation of the aorta walls. The small tear can become larger. It can lead to bleeding into and along the wall of the aorta, the major artery carrying blood out of the heart. SIDER: C0340643 ruptured cerebral aneurysm AE 10039330 WEB: http://ether.stanford.edu/library/neuroanesthesia/Journal%20Articles/Ruptured%20cerebral%20aneurysms.pdf SS WEB: http://www.ncbi.nlm.nih.gov/pubmed/15647574 an aneurysm ruptured AE that occurs in the brain where blood spurts into the subarachnoid space under arterial pressure, continuing until increased local or generalized intracranial pressure stops the bleeding. intracranial aneurysm AE 10022758 cerebral aneurysm AE brain aneurysm AE SS intracerebral aneurysm AE HPO: HP_0004944 SIDER: C0007766 an aneurysm AE that occurs in the brain WEB: http://www.ninds.nih.gov/disorders/cerebral_aneurysm/detail_cerebral_aneurysms.htm aortic thrombosis AE 10002910 SS a thrombosis AE that is a rare lesion and may be defined as a thrombosis of a vessel without any obvious underlying cause that occurs in the aorta WEB: http://circ.ahajournals.org/content/17/5/941.full.pdf carotid artery thrombosis AE 10007688 an arterial thrombosis AE that is characterized by the occurrence of a thrombus in the carotid arteries (two large blood vessels that supply oxygenated blood to the large, front part of the brain) WEB: http://www.webmd.com/heart-disease/carotid-artery-disease-causes-symptoms-tests-and-treatment SS cerebral artery embolism AE 10008088 10014498 10043647 an arterial embolism AE that occurs in the cerebral artery SS thrombotic stroke AE WEB: http://medical-dictionary.thefreedictionary.com/cerebral+embolism embolic stroke AE cerebral embolism AE cerebral artery thrombosis AE 10008092 10008132 [SS] Per DRA and KKB's comment, this term may also be characterized as a type of embolism even though labeled thrombosis. an arterial thrombosis AE that occurs in the cerebral artery, also referred to as an embolism AE cerebral thrombosis AE cerebral venous thrombosis AE 10008138 a venous thrombosis AE that is characterized by thrombosis of the venous channels in the brain. It is an uncommon cause of cerebral infarction relative to arterial disease, but it is an important consideration because of its potential morbidity. SS WEB: http://emedicine.medscape.com/article/1162804-overview [SS] From http://medical-dictionary.thefreedictionary.com/cerebral+venous+thrombosis, Merwarth syndrome - progressive hemiplegia due to venous occlusion. Synonym(s): cerebral venous thrombosis intracranial venous sinus thrombosis AE 10061251 SS WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/cerebral_venous_sinus_thrombosis_134,69/ CVST a venous thrombosis AE that occurs when a blood clot forms in the brain’s venous sinuses that prevents blood from draining out of the brain. As a result, blood cells may break and leak blood into the brain tissues, forming a hemorrhage. gas embolilsm AE SS [SS] The term 'gas embolism' is listed as a unique term, and not a superset or a synonym of 'air embolism' due to the different pathology reconized by physicians that air embolism is mostly recognized when an air bubble caused by IV or other injection device enters the vein, while a gas embolism is mostly caused by a gas bubble released as a product of an infection, or other devices such as nitrogen tank. an embolism AE that is caused by a gas bubble that enters the vein mesenteric vein thrombosis AE 10027402 a thrombosis that is characterized by a clot that blocks blood flow a mesenteric vein, one of two veins through which blood leaves the intestine. The condition interrupts the blood supply to the intestine and can result in damage to the intestines. SS [SS] http://emedicine.medscape.com/article/193921-overview, Mesenteric venous thrombosis (also known as visceral venous thrombosis) is a rare but lethal form of mesenteric ischemia (see the image below). Antonio Hodgson first described mesenteric ischemia in the latter part of the 15th century. In 1895, Elliot first described mesenteric venous thrombosis as a cause of mesenteric ischemia. By the turn of the 19th century, many review articles and texts were describing the recent advances in the characterization and treatment of mesenteric ischemia, particularly venous thrombosis. In 1935, Warren and Eberhard reported that intestinal infarction resulted from ischemia due to venous thrombosis, and they reported a mortality rate of 34% in patients with venous thrombosis after resection. Unfortunately, despite improvements in therapy, this mortality rate still holds. visceral venous thrombosis AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001157.htm mesenteric venous thrombosis AE Budd-Chiari syndrome AE 10006537 a thrombosis AE that is an uncommon condition induced by thrombotic or nonthrombotic obstruction of hepatic venous outflow and characterized by hepatomegaly, ascites, and abdominal pain. WEB: http://emedicine.medscape.com/article/184430-overview SS retinal vein thrombosis AE 10038908 a thrombosis AE that occurs in the vein carrying the blood away from the retina [SS] The term 'retinal vein thrombosis' is listed as a different class from 'retinal vein occlusion' for the difference in the pathological process of how the blockage occurs in the vein. SS predictive AE causality Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20. predictive causality of adverse event an adverse event causity that represents a predictive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: will the next person who received a medical intervention will develop the adverse event? Or: how frequently will vaccine recipients experience the adverse event as a result of a medical intervention? YH arterial embolism AE 10014513 SS embolism arterial AE an embolism AE that occurs in the artery. It is a sudden interruption of blood flow to an organ or body part due to a clot (embolus). WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001102.htm venous embolism AE 10014522 venous thromboembolism AE [SS] Per DRA and KKB's comment, this term is synonymous to venous thrombosis even though labeled embolism. Cross-reference is made via seeAlso. a thrombosis AE* that is a result of when a blood vessel is obstructed by a blood clot (embolus) that has been carried in the bloodstream from the site of its formation. Thromboembolic disease includes both venous thromboembolism (VTE) and arterial thrombosis. VTE is an general term which refers to mainly two conditions: deep vein thrombosis (DVT) and its potentially fatal acute complication, pulmonary embolism (PE). Arterial embolism is a frequent complication in patients with atrial fibrillation (AF) and can lead to stroke or systemic embolism. * see editor note VTE embolism venous AE OAE: 0001505 SS WEB: http://www.boehringer-ingelheim.com/products/prescription_medicines/thromboembolic_diseases.html fat embolism AE 10016246 SS WEB: http://emedicine.medscape.com/article/460524-overview#showall an embolism AE that is characterized by the obstruction of blood vessel by fat droplets septic embolus AE 10040067 a embolism AE that is infected with bacteria containing pus SS septic embolism AE WEB: http://www.medicalnewstoday.com/articles/153704.php thrombosis in device AE 10062546 SS a thrombosis AE that occurs in or may be caused by an implanted device in the body obsolete: thrombotic microangiopathy AE 10043645 SS TMA WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583 This term is obsolete since there is another term with the same name already. Oliver a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion arterial thrombosis limb AE 10003180 an arterial thrombosis AE that occurs in the limb(s) of the body SS eye inflammation AE an inflammation AE that occurs in eye. YH, JX injection site thrombosis AE 10022104 SS pelvic venous thrombosis AE 10034272 SS ovarian vein thrombosis AE WEB: http://emedicine.medscape.com/article/404364-overview a deep vein thrombosis AE that occurs in the pelvis. Ovarian vein thrombosis arises out of the coincident conditions of venous stasis and hypercoagulability, which are commonly present in the recently postpartum patient. peripheral embolism AE 10061340 PE an embolism AE that is charaterized by a sudden blockage in a lung artery. The blockage usually is caused by a blood clot that travels to the lung from a vein in the leg. SS WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/pe/ subclavian vein thrombosis AE 10049446 SS a thrombosis AE that occurs in subclavian vein. Among patients with effort-induced thrombosis with subclavian vein stenosis, the thrombosis occurs in the dominant arm in 80% of cases. WEB: http://emedicine.medscape.com/article/424777-overview#showall superficial thrombophlebitis AE WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000199.htm NCIt: C78634 CTCAE: E13817 YH: MedDRA: 10043595 is for "thrombophlebitis superficial"; MedDRA: 10042554 is for "superficial thrombophlebitis" SS, YH, MW a thrombophlebitis AE that is characterized by an inflammation of a vein due to a blood clot in a vein located just below the skin's surface. 表在性血栓性静脈炎 UMLS CUI: C1510431 thrombophlebitis superficial AE venous thrombosis limb AE 10061408 SS retinal vein occlusion AE 10038907 RVO SS a thrombosis that is characterized by a blockage of the small veins that carry blood away from the retina. The retina is the layer of tissue at the back of the inner eye that converts light images to nerve signals and sends them to the brain. WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007330.htm atrial thrombosis AE 10048632 WEB: http://ehjcimaging.oxfordjournals.org/content/9/1/204.full SS a thrombosis AE that occurs in the atrium (left or right) coronary artery embolism AE 10011084 10011091 an arterial embolism AE that occurs in the coronary artery coronary artery thrombosis AE coronary embolism AE WEB: http://medical-dictionary.thefreedictionary.com/Coronary+embolism SS sleep apnea AE 10040975 CTCAE: E13566 MW, YH NCIt: C26884 WEB: http://www.mayoclinic.org/diseases-conditions/sleep-apnea/basics/definition/con-20020286 a sleep apnea AE is a sleep disorder AE in which breathing repeatedly stops and starts. Basically, it is a crossproduct of sleep disorder AE and apnea AE. stroke AE 10042244 WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/stroke/ cardiovascular accident AE CTCAE: E12826 WEB: http://en.wikipedia.org/wiki/Stroke JX, LW, YH 中风 a brain AE that occurs when flow of oxygen-rich blood to a portion of the brain is blocked NCIt: C3390 ischemic stroke AE 10061256 WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ ischaemic stroke AE a stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain. SS hemorrhagic stroke AE 10019016 a stroke AE that occurs when a blood vessel that supplies the brain ruptures and bleeds causing the deficiency of oxygen and nutrients to brain cells and tissues SS haemorrhagic stroke AE WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ intracerebral hemorrhagic stroke AE WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ intracerebral haemorrhagic stroke AE SS a haemorrhagic stroke AE that is cuased by hypertension (high blood pressure), and bleeding occurs suddenly and rapidly. subarachnoid hemorrhagic stroke AE a haemorrhagic stroke AE that is cuased by the bleeding (haemorrhage) between the brain and the meninges (the membrane that covers the brain) in the subarachnoid space. subarachnoid haemorrhagic stroke AE SS WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ thrombotic stroke AE 10043647 WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ an ischaemic stroke AE that is caused by a thrombus (blood clot) that develops in the arteries supplying blood to the brain SS embolic stroke AE 10014498 SS an ischaemic stroke AE that is caused by an embolus (a blood clot that formms elsewhere in the body and travels through the bloodstream to the brain). WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/ psychiatric disorder AE 10037175 WEB: http://en.wikipedia.org/wiki/Mental_disorder a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative. YH, Izabela Birsanescu mental disorder AE adjustment disorder AE 10001301 10001302 WEB: http://www.healthline.com/health/adjustment-disorder a psychiatric disorder AE that has an outcome of a adjustment disorder. An adjustment disorder is an unexpectedly strong emotional or behavioral reaction that occurs in response to an identifiable stressful life event or life change that occurred within the previous three months. Yongqun He, Izabela Birsanescu adjustment disorder with depressed mood AE 10001297 Yongqun He, Izabela Birsanescu WEB: http://www.summitmedicalgroup.com/library/adult_health/bha_adjustment_disorder_with_depressed_mood/ an adjustment disorder AE that has an additional depressed mood. The person is more depressed than would be expected after a stressful event. anastomotic bleeding AE 10071781 a hemorrhage AE that has an outcome of bleeding from anastomosis site. Anastomosis: pathological formation of an opening between two normally distinct spaces or organs. WEB: http://medical-dictionary.thefreedictionary.com/anastomosis Yongqun He, Izabela Birsanescu Clostridium difficile infection AE 10054236 Yongqun He, Izabela Birsanescu WEB: http://www.mayoclinic.org/diseases-conditions/c-difficile/basics/definition/CON-20029664?p=1 a clostridial infection AE that is caused by C. difficule. Gram-negative bacteremia AE 10054228 a bacteraemia AE that is more specifically associated with a Gram-negative bacterium. Yongqun He, Izabela Birsanescu drug level increase a physical quality that a drug level inside a host increases Yongqun He, Izabela Birsanescu drug toxicity WEB: http://medical-dictionary.thefreedictionary.com/drug+toxicity Yognqun He, Izabela Birsanescu a quality that represents the level of critical or lethal reaction to an erroneous dosage of a drug medication. Drug toxicity may occur due to human error or intentional overdose in the case of suicide or homicide. Intraoperative hemorrhage AE 10055298 CTCAE: E11810 a hemorrhage AE that has an outcome of massive amounts of blood loss. A typical Intraoperative hemorrhage has a blood loss exceeding 1000 mL or requires a blood transfusion NCIt: C35135 WEB: http://www.uptodate.com/contents/management-of-hemorrhage-in-gynecologic-surgery Yongqun He, Izabela Birsanescu pancreatic abscess AE 10048984 Yongqun He, Izabela Birsanescu WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000270.htm an abscess AE that shows a cavity of pus within the pancreas pancreas transplant rejection AE 10049169 a sugery AE that has an adverse outcome where the recipient’s body rejects the pancreas transplantation. WEB: http://www.medscape.com/viewarticle/436542_13 Yongqun He, Izabela Birsanescu pyogenic infection AE 10021861 Yongqun He, Izabela Birsanescu WEB: http://www.medilexicon.com/medicaldictionary.php?t=44396 an infection AE that has an outcome of a severe local inflammation, usually with pus formation, generally caused by one of the pyogenic bacteria. fever of unknown origin AE 10016563 WEB: http://medicine.academic.ru/123590/fever_of_unknown_origin Yongqun He, Izabela Birsanescu a fever AE that has unknown origin. time interval for initial process after medical intervention a temporal interval that starts at the time a medical intervention occurs and ends at the time when the initial bodily process occurs. Yongqun He time interval for intermediate causal AE process Yongqun He a temporal interval that starts at the time in the end of the initial process and ends at the time when the final process leading to an adverse event clinical outcome occurs. time interval for AE process showing clinical outcome a temporal interval that covers the time period of the final process leading to the display of clinical outcome. Yongqun He initial stage causal AE sub-process Yongqun He a pathological bodily process that starts to occur after a medical intervention. intermediate stage causal AE sub-process a pathological bodily process that occurs in the middle of the causal adverse event process, i.e., after the initial causal AE process and before the last AE process that results in the adverse outcome. Yongqun He late stage AE formation sub-process a pathological bodily process that occurs in the last stage of adverse event and results in the adverse clinical outcome. This clinical outcome may come as a result of causal adverse event (caused by the medical intervention), or result from an unrelevant cause (i.e., not the designated medical intervention). Yongqun He AE process showing pathological clinical outcome adverse event time period a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event ends. The adverse event ends when the patient recovers from the adverse event or dies due to the severity of the adverse event. Yongqun He patient an organism that has the role of 'patient role'. Yongqun He time interval for causal AE Yongqun He an adverse event tme period whent the adverse event is causal adverse event. causality based on Naranjo ADR probability scale WEB: http://livertox.nih.gov/Narajo.html a causality of AE based on the Naranjo ADR probability scale method. Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. Yongqun He SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Definite Naranjo ADR probability Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. a Naranjo ADR probability scale that shows definite causality result. It happens when the score is >=9. Yongqun He SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful WEB: http://livertox.nih.gov/Narajo.html Probably Naranjo ADR probability WEB: http://livertox.nih.gov/Narajo.html a Naranjo ADR probability scale that shows probable causality result. It happens when the score is 5-8. Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful Possible Naranjo ADR probability Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. Yongqun He a Naranjo ADR probability scale that shows possible causality result. It happens when the score is 1-4. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful WEB: http://livertox.nih.gov/Narajo.html Doubtful Naranjo ADR probability WEB: http://livertox.nih.gov/Narajo.html Yongqun He Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508. a Naranjo ADR probability scale that shows doubtful causality result. It happens when the score is <=0. SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful AE causality based on CDISC system Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf Yongqun He a causality of AE that is based on the Clinical Data Interchange Consortium (CDISC) system causality based on the Clinical Data Interchange Consortium (CDISC) system Not Related AE causality based on CDISC system Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. an AE causality based on CDISC system that has the scale "Not Related". WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf Yongqun He Possibly Related AE causality based on CDISC system Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf an AE causality based on CDISC system that has the scale "Possibly Related". Yongqun He Unlikely Related AE causality based on CDISC system Yongqun He Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. an AE causality based on CDISC system that has the scale "Unlikely Related". WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf Definitely Related AE causality based on CDISC system WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf an AE causality based on CDISC system that has the scale "Definitely Related". Yongqun He Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. Probably Related AE causality based on CDISC system an AE causality based on CDISC system that has the scale "Probably Related". Yongqun He WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448. causality based on DIPS score Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Yongqun He an AE causality that is based on the Drug Interaction Probability Scale (DIPS). Highly Probable causality based on DIPS score Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Yongqun He a causality based on DIPS score that is "Highly Probable". It occurs when the sore is >8. Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Probable causality based on DIPS score Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Yongqun He a causality based on DIPS score that is "Probable". It occurs when the sore is 5-8. Possible causality based on DIPS score Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 a causality based on DIPS score that is "Possible". It occurs when the sore is 2-4. Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Yongqun He Doubtful causality based on DIPS score a causality based on DIPS score that is "Doubtful". It occurs when the sore is <2. Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673. Score: Highly Probable: >8 Probable: 5–8 Possible: 2–4 Doubtful: <2 Yongqun He AE severity G0 YH, SS a severity of AE that shows sign and symptom within normal limits. AE severity Grade 0 CTCAE4: E10004 (Grade 0 Adverse Event) Note the AE severity Grade 0 equals to CTCAE G0 AE severity. Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_0_Adverse_Event AE severity G1 AE severity Grade 1 CTCAE4: E10005 (Grade 1 Adverse Event) YH, SS a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated. Note the AE severity Grade 1 equals to CTCAE G1 AE severity. Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event AE severity G2 a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances). Note the AE severity Grade 2 equals to CTCAE G2 AE severity. Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event YH, SS CTCAE4: E10006 (Grade 2 Adverse Event) AE severity Grade 2 AE severity G3 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event AE severity Grade 3 YH, SS CTCAE4: E10007 (Grade 3 Adverse Event) Note the AE severity Grade 3 equals to CTCAE G3 AE severity. a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). AE severity G4 AE severity Grade 4 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral). Note the AE severity Grade 4 equals to CTCAE G4 AE severity. CTCAE4: E10008 (Grade 4 Adverse Event) YH, SS AE severity G5 Note the AE severity Grade 5 equals to CTCAE G5 AE severity. YH, SS AE severity Grade 5 Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event CTCAE4: E10009 (Grade 5 Adverse Event) a severity of AE that results in death. hyperphosphatemia AE 10020712 WEB: https://en.wikipedia.org/wiki/Hyperphosphatemia HPO: HP_0002905 a blood phosphate abnormal AE that has an abnormally increased amount of phosphate in the blood EB, YH, MW X-ray clinical test a clincal laboratory test that performs a medical examination using X-ray, a type of electromagnetic radiation. WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003337.htm Rebecca Racz, Yongqun He cardio-respiratory distress AE 10049874 WEB: http://medicalcenter.osu.edu/patientcare/healthcare_services/lung_diseases/about/signs/Pages/index.aspx, http://www.merriam-webster.com/dictionary/cardiorespiratory a respiratory distress AE that has an outcome of insufficient oxygen flow in the heart and respiratory system. SS, YH joint effusion AE 10023215 CTCAE:E12431 RR, YH, MW A joint disorder AE that has the presence of increased intra-articular fluid. It can be caused by trauma, arthritis, or gout and often affects the knee. PMID: 19915432 NCIt:C49052 WEB: http://en.wikipedia.org/wiki/Joint_effusion gastric disorder AE 10056819 stomach disorder AE a gastrointestinal disorder AE that shows a problem with the stomach, ranging from indigestion and heartburn to peptic ulcers and GERD. RR, YH WEB: http://www.nlm.nih.gov/medlineplus/stomachdisorders.html fluid replacement 10061858 WEB: http://www.mayoclinic.org/diseases-conditions/dehydration/basics/treatment/con-20030056 fluid resuscitation A medical intervention that involves the replacement of bodily fluids excessively lost. Fluids may be replaced orally or intravenously. RR, YH thyroiditis AE http://www.endocrineweb.com/conditions/thyroid/thyroiditis An inflammation AE that displays an inflammation (not an infection) of the thyroid gland. yongqun he, liwei wang glucosuria AE web: http://en.wikipedia.org/wiki/glycosuria LW, YH a urinary system AE that has an outcome of the excretion of glucose into the urine. granuloma AE 10018691 WEB: http://www.mayoclinic.org/granuloma/expert-answers/faq-20057838 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3629 KM, JX, YH an inflammation AE that shows localized nodular inflammation found in tissues. WEB: http://en.wikipedia.org/wiki/Granuloma skin burning sensation AE 10054786 KM, JX, YH a burning sensation AE that occurs at the skin. numbness AE 10029829 YH, JS a sensory capability AE that has an outcome of numbness, a loss of sensation of feeling in a part of the body. WEB: http://www.mayoclinic.org/symptoms/numbness/basics/definition/sym-20050938 interstitial pneumonia AE 10022617 a pneumonia AE that occurs at the interstitial lung. Interstitial pneumonia is often caused by an infection of bacteria, viruses, or fungii. A bacterium called Mycoplasma pneumonia is the most common cause. WEB: http://www.webmd.com/lung/interstitial-lung-disease JX, YH circumoral numbness AE 10049339 a numbness AE that occurs around the mouth. YH, JS WEB: http://link.springer.com/referenceworkentry/10.1007%2F3-540-29623-9_6515 The terms 'circumoral numbness AE' and 'circumoral paresthesia AE' appear to be synonyms. skin necrosis AE 10040893 JX, LW, YH UMLS ID: C0151799 皮肤坏死 Skin necrosis AE is a necrosis AE that results in the death of the skin tissue. Skin necrosis often occurs when not enough blood and oxygen are supplied to a given skin region. systemic lupus erythematosus AE SLE 系统性红斑狼疮 系统性红斑狼疮综合征 systemic lupus erythematosus syndrome AE JX, LW, YH WEB: http://www.healthline.com/health/systemic-lupus-erythematosus#Overview1 WEB: http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus Systemic lupus erythematosus (SLE) syndrome AE is a lupus syndrome AE that is systemic and disseminated. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. Although “lupus” actually includes a number of different diseases, SLE is the most common type of lupus, and when people say “lupus,” they are often referring to SLE. urgent urination AE 10046593 urinary urgency UMLS CUI: C0439609 NCIt: C50792 CTCAE: E13062 Urgent urination AE is a urinary system AE that has an outcome of a sudden, compelling urge to urinate, along with discomfort in the bladder. WEB: http://sideeffects.embl.de/se/C0085606/ WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003140.htm JX, LW, YH 尿急 micturition urgency precordialgia AE Precordialgia AE is a pain AE that pain located in the precordial region. WEB: http://www.drugs.com/dict/precordialgia.html JX, LW, YH 心前痛 dyshidrosis AE 10013912 Dyshidrosis AE is a skin AE that shows a disorder of eccrine sweat glands, characterized by small blisters on the hands or feet. 汗疱疹 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Dyshidrosis ankle swelling AE 10002554 踝部水肿 UMLS ID: C0235439 Ankle swelling AE is an edema AE that shows abnormal buildup of fluid in the ankles. Ankle swelling is a sign of fluid buildup or inflammation of the joint and tissues of the ankle. Mild ankle swelling is a common occurrence after standing for a long period. WEB: http://www.healthgrades.com/symptoms/ankle-swelling JX, LW, YH renal dysfunction AE hepatic and renal function disorder AE 肾功能障碍 JX, LW, YH Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia. This term appears to be a synonym to the 'renal failure AE'. UMLS ID: C0859242 epiphora AE 10015068 WEB: http://en.wikipedia.org/wiki/Epiphora_(medicine) Epiphora AE is a eye AE that shows an overflow of tears onto the face. In this case, there is insufficient tear film drainage from the eyes, and the tears will drain down the face rather than through the nasolacrimal system. UMLS ID: C0152227 泪溢 JX, LW, YH hemolytic anemia AE 10019493 JX, LW, YH 溶血性贫血 WEB: http://en.wikipedia.org/wiki/Hemolytic_anemia Hemolytic anemia AE is an anemia AE associated with hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). Such an AE can be relatively harmless or life-threatening. somniloquy AE JX, LW, YH 梦呓 a behavioral and neurological AE where somniloquy also is called sleep-talking, a parasomnia that refers to talking aloud while asleep. Somniloquy can be quite loud, ranging from simple mumbling sounds to loud shouts and long frequently inarticulate speeches, and can occur many times during a sleep cycle. As with sleepwalking and night terrors, sleeptalking usually occurs during the less-deep delta-wave NREM sleep stages or during temporary arousals therefrom. WEB: http://en.wikipedia.org/wiki/Somniloquy cholelithiasis AE 10008629 UMLS ID: C1328486 WEB: http://en.wikipedia.org/wiki/Gallstone Cholelithiasis AE is a liver, biliary, and pancreatic AE that shows hard deposits forming inside the gallbladder. Gallstones may be as small as a grain of sand or as large as a golf ball. JX, LW, YH blepharoptosis AE 10005157 JX, LW, YH 眼睑下垂 WEB: http://eyewiki.aao.org/Blepharoptosis Blepharoptosis AE is an eye AE that shows droopy upper eyelid or ptosis that presents with substantial blockage upper part of field of vision, risk of amblyopia among young children, and dramatic change in the facial appearance. AE associated dose range AG, YH A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to, at which point AE symptoms begin to arise. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. OBI AE recovery NCI Thesaurus AG, YH A healing process that leads to an outcome with improved relative health from an adverse event AE recovery rate an AE recovery rate that represents a rate of adverse event recovery AG, YH chemotherapy drug AE recovery An AE recovery that is sepcifically for recovery from a chemotherapy drug adverse event. AG, YH complete AE recovery AG, YH extent of AE recovery an information content entity that represents an extent of recovery from an adverse event AG, YH incomplete AE recovery AG, YH an extent of AE recovery that has an outcome of incomplete recovery grand mal AE 10018658 an epileptic seizure AE that is characterized by tonic-clonic seizures, involving two phases -- the tonic phase in which the body becomes rigid, and clonic phase in which there is uncontrolled jerking. JX, LW, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32957 癫痫大发作 erythema simplex AE 单纯性红斑 JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/erythema+simplex Erythema simplex AE is an erythema AE that accompany with blushing or redness of the skin caused by a toxic reaction or a neurovascular phenomenon. pelvic pain AE 10034263 Pelvic pain AE is a pain AE that occurs in the lower abdomen area. The pain might be steady, or it might come and go. If the pain is severe, it might get in the way of people's daily activities. 骨盆痛 JX, LW, YH, MW CTCAE:E13167 NCIt:C40122 WEB: http://www.nlm.nih.gov/medlineplus/pelvicpain.html extrasystoles AE 10015856 早搏（额外收缩） JX, LW, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32159 Extrasystoles AE is an arrhythmia AE that shows a premature contraction of the heart that is independent of the normal rhythm of the heart and arises in response to an impulse in some part of the heart other than the normal impulse from the sinoatrial node. The extrasystole is followed by a pause, as the heart electrical system "resets" itself and the contraction following the pause is usually more forceful than normal. increased upper airway secretion AE 10062717 An increased upper airway secretion AE is a respiratory system AE characterized by an increased secretion at the upper airway location. RR, YH feeling of body temperature change AE 10061458 RR, YH Feeling of body temperature change AE is a feeling abnormal AE that a patient feels a change in body temperature. heartburn AE 10019326 Heartburn AE is a gastric disorder AE that also known as pyrosis, cardialgia, or acid indigestion. It's a burning sensation in the chest, just behind the breastbone or in the epigastrium, the upper central abdomen. The pain often rises in the chest and may radiate to the neck, throat, or angle of the jaw. WEB: http://en.wikipedia.org/wiki/Heartburn JX, LW, YH 胃灼热（烧心） tonsillitis AE 10044008 JX, LW, YH 扁桃体炎 WEB: http://en.wikipedia.org/wiki/Tonsillitis Tonsillitis AE is an inflammation AE that is inflammation of the tonsils most commonly caused by viral or bacterial infection. Symptoms may include sore throat and fever. non-insulin-dependent diabetes mellitus AE 10029505 WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 非胰岛素依赖型糖尿病 JX, LW, YH Non-insulin-dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 2, it's characterized by hyperglycemia (high blood sugar) in the context of insulin resistance and relative lack of insulin. insulin dependent diabetes mellitus AE 10022497 WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1 JX, LW, YH 胰岛素依赖型糖尿病 Insulin dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 1. It results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. areflexia AE 10003084 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423 a hyporeflexia AE where the patient shows no sign of reflexes. 反射消失 JX, LW, YH mastauxe AE 乳房增大 JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/mastauxe Mastauxea AE is a reproductive system AE that shows enlargement of the breast. uveitis AE 10046851 色素层炎 JX, LW, YH CTCAE: E10442 Uveitis AE is an inflammation AE that is inflammation of the uvea, which lines the inside of the eye behind the cornea. NCIt: C26909 WEB: http://en.wikipedia.org/wiki/Uveitis sexual dysfunctions AE 10040477 性功能障碍 sexual malfunction AE JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sexual_dysfunction Sexual dysfunctions AE is a reproductive system AE that is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm. hypomnesia AE 10021035 JX, LW, YH 记忆减退 WEB: http://psychology.wikia.com/wiki/Hypomnesia Hypomnesia AE is a behavior and neurological AE that is an archaic term applied to poor memory, the impaired ability to recall information previously memorized. phobia AE 10034912 恐惧症 WEB: http://en.wikipedia.org/wiki/Phobia JX, LW, YH Phobia AE is a behavior and neurological AE that is a type of anxiety disorder, usually defined as a persistent fear of an object or situation in which the sufferer commits to great lengths in avoiding, typically disproportional to the actual danger posed, often being recognized as irrational. lymphadenectasis AE 10025282 JX, LW, YH Lymphadenectasis AE is an edema AE that shows enlargement of the lymph node. 淋巴结肿大 WEB: http://medical-dictionary.thefreedictionary.com/lymphadenectasis asterixis AE 10003547 Asterixis AE is a tremor AE that also called the flapping tremor, or liver flap, which is a tremor of the hand when the wrist is extended, sometimes said to resemble a bird flapping its wings. This motor disorder is characterized by an inability to actively maintain a position, which is demonstrated by jerking movements of the outstretched hands when bent upward at the wrist. The tremor is caused by abnormal function of the diencephalic motor centers in the brain, which regulate the muscles involved in maintaining position. WEB: http://en.wikipedia.org/wiki/Asterixis 扑翼样震颤 JX, LW, YH parageusia AE 10033793 味觉颠倒 JX, LW, YH Parageusia AE is a gustatory system AE which is the medical term for a bad taste in the mouth. One common form of parageusia is a metallic taste of food. This can be a side effect of several medications, such as acetazolamide, eszopiclone, zopiclone, metronidazole, or etoposide. Metallic taste is also a type of dysgeusia which is frequently associated with infections in the mouth or upper airways. WEB: http://en.wikipedia.org/wiki/Parageusia brain damage AE 10056389 Brain damage AE is a brain AE that also called brain injury is the destruction or degeneration of brain cells. In general, brain damage refers to significant, undiscriminating trauma-induced damage. WEB: http://en.wikipedia.org/wiki/Brain_damage JX, LW, YH 脑损伤 frequent bowel movements AE 10017367 大便频繁 JX, LW, YH WEB: http://www.healthgrades.com/symptoms/frequent-bowel-movements Frequent bowel movements AE is a abnormal stool AE that people are having more bowel movements than is normal for them. Often, frequent bowel movements are accompanied by diarrhea, the passage of loosely formed stool. hyperprolactinemia AE 10020739 Hyperprolactinemia AE is an endocrine investigation result abnormal AE that is the presence of abnormally high levels of prolactin in the blood. Normal levels are less than 500 mIU/L [20 ng/mL or µg/L] for women, and less than 450 mIU/L for men. 高泌乳素血症 WEB: http://en.wikipedia.org/wiki/Hyperprolactinaemia JX, LW, YH galactorrhea AE 10017592 JX, LW, YH 乳溢 WEB: http://en.wikipedia.org/wiki/Galactorrhea Galactorrhea AE is a reproductive system AE that is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing. sitophobia AE JX, LW, YH WEB: http://en.wiktionary.org/wiki/sitophobia Sitophobia AE is a behavior and neurological AE that shows a morbid or insane dread of eating. 畏食 ejection murmur AE 收缩期喷射性杂音 Ejection murmur AE is a cardiac disorder AE which is due to turbulent forward flow across the right and left ventricular outflow tract, aortic or pulmonary valve, or through the aorta or pulmonary artery. JX, LW, YH WEB: http://www.cardiologysite.com/auscultation/html/ejection_murmurs.html hypoactive sexual desire disorder AE 10020933 hyposexuality AE JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder 性欲减退 Hypoactive sexual desire disorder AE is a libido disorder AE that is considered a sexual dysfunction and is characterized as a lack or absence of sexual fantasies and desire for sexual activity, as judged by a clinician. bigotry AE WEB: http://en.wikipedia.org/wiki/Bigotry JX, LW, YH 偏执 Bigotry AE is a behavior and neurological AE that is a state of mind where a person strongly and unfairly dislikes other people, ideas, etc. somnambulism AE 10041347 Somnambulisma AE is a behavior and neurological AE that also known as sleepwalking or noctambulism, which is a sleep disorder belonging to the parasomnia family. It arise from the slow wave sleep stage in a state of low consciousness and perform activities that are usually performed during a state of full consciousness. These activities can be as benign as sitting up in bed, walking to the bathroom, and cleaning, or as hazardous as cooking, driving, violent gestures, grabbing at hallucinated objects, or even homicide. sleepwalking AE noctambulism AE JX, LW, YH 梦游症 WEB: http://en.wikipedia.org/wiki/Sleepwalking hyperphagia AE 10020710 食欲过盛 Hyperphagia AE is an eating disorder AE that also called polyphagia. It's a medical sign meaning excessive hunger and abnormally large intake of solids by mouth. It can be caused by disorders such as diabetes, Kleine–Levin syndrome (a malfunction in the hypothalamus), the genetic disorders Prader–Willi syndrome, and Bardet–Biedl syndrome. polyphagia AE WEB: http://en.wikipedia.org/wiki/Polyphagia JX, LW, YH corneal pigmentation AE 10011040 Corneal pigmentation is a eye AE shows that the melanin is in the superficial stroma and the basal layer of the corneal epithelium. 角膜色素沉着 JX, LW, YH WEB: http://medical-dictionary.thefreedictionary.com/corneal+pigmentation chromatosis AE 色素沉着 WEB: http://www.merriam-webster.com/medical/chromatosis JX, LW, YH Chromatos AE is a skin AE shows that deposit of pigment in a normally unpigmented area or excessive pigmentation in a normally pigmented site. subclavian steal syndrome AE 10042335 subclavian steal phenomenon AE 锁骨下动脉盗血综合征 JX, LW, YH Subclavian steal syndrome AE is an ischaemia AE that is a constellation of signs and symptoms that arise from retrograde (reversed) flow of blood in the vertebral artery or the internal thoracic artery, due to a proximal stenosis (narrowing) and/or occlusion of the subclavian artery. The arm may be supplied by blood flowing in a retrograde direction down the vertebral artery at the expense of the vertebrobasilar circulation. This is called the subclavian steal. subclavian steal steno-occlusive disease AE allergic rhinitis AE 10001723 Allergic rhinitis AE is a rhinitis AE that is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system. 过敏性鼻炎 WEB: http://en.wikipedia.org/wiki/Allergic_rhinitis NCIt:C79532 CTCAE:E13303 JX, LW, YH, MW ventricular ectopic beats AE 10058291 心室异位搏动 WEB: http://en.wikipedia.org/wiki/Ectopic_beat JX, LW, YH Ventricular ectopic beats AE is a cardiac ventricular disorder AE that is a disturbance of the cardiac rhythm frequently related to the electrical conduction system of the heart, in which beats arise from fiber or group of fibers outside the region in the heart muscle ordinarily responsible for impulse formation. sjogren syndrome AE 10040767 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sj%C3%B6gren's_syndrome 干燥综合症 Sjogren syndrome AE is a eye AE that is a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands, that produce saliva and tears, respectively. nocturia AE 10029446 夜尿症 WEB: http://en.wikipedia.org/wiki/Nocturia nycturia AE Nocturia AE is a urine abnormality AE that is defined by the International Continence Society as “the complaint that the individual has to wake at night one or more times for voiding”. JX, LW, YH night sweat AE 10029409 夜汗 JX, LW, YH sleep hyperhidrosis AE WEB: http://en.wikipedia.org/wiki/Night_sweats Night sweat is a sweating AE that is the occurrence of excessive sweating (hyperhidrosis and focal hyperhidrosis) during sleep. The sufferer may or may not also suffer from excessive perspiration while awake. increased appetite AE 10021654 Increased appetite AE is a gustatory system AE that is when people want to eat much more often or in larger quantities than their body requires. 食欲增加 JX, LW, YH WEB: http://www.healthline.com/symptom/increased-appetite vascular dilatation headache AE 血管扩张性头痛 JX, LW, YH Vascular dilatation headache AE is a headache AE that shows headache which caused by vascular dilatation. WEB: http://www.headaches.org/education/Headache_Topic_Sheets/Vascular_Headaches bundle-branch block AE 10006578 Bundle-branch block AE is a conduction system disorder AE that refers to a defect of the heart's electrical conduction system. 束支传导阻滞 WEB: http://en.wikipedia.org/wiki/Bundle_branch_block JX, LW, YH unstable diabetes AE 10006372 labile diabetes AE JX, LW, YH Unstable diabetes AE is a diabetes mellitus AE that is a type of diabetes when a person's blood glucose level often swings quickly from high to low and from low to high. 不稳定型糖尿病 brittle diabetes AE WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=7271 tendon rupture AE 10043248 WEB: http://medical-dictionary.thefreedictionary.com/Tendon+rupture 肌腱断裂 Tendon rupture AE is a tendon disorder AE shows a tearing of the tendon that occurs when the forces placed upon the tendon exceed its tensile strength. JX, LW, YH tendovaginitis AE 10067216 腱鞘炎 WEB: http://encyclopedia2.thefreedictionary.com/Tendovaginitis Tendovaginitis AE is an inflammation AE that is an acute or chronic inflammation of the tendon sheath, occurring in the region of the hand, the wrist joint, the forearm (radial and ulnar tenobursitis), the foot, the ankle joint, and the Achilles tendon (achillobursitis). JX, LW, YH tenovaginitis AE loose stools AE 10024840 JX, LW, YH Loose stools AE is a abnormal stool AE that is usually a form of diarrhea and many conditions causing loose stool will be listed under diarrhea. It may also be related to watery stool (also within the spectrum of diarrhea). WEB: http://www.rightdiagnosis.com/sym/loose_stool.htm 稀便 cystitis AE 10011781 膀胱炎 JX, LW, YH Cystitis AE is an inflammation AE that is the medical term for inflammation of the bladder. Most of the time, the inflammation is caused by a bacterial infection, and it's called a urinary tract infection. WEB: http://www.mayoclinic.org/diseases-conditions/cystitis/basics/definition/con-20024076 eructation AE 10015137 JX, LW, YH ructus AE WEB: http://en.wikipedia.org/wiki/Burping burping AE belching AE Eructation AE is a digestive system AE that is the release of gas from the digestive tract (mainly esophagus and stomach) through the mouth. It is usually accompanied with a typical sound and, at times, an odor. 嗳气 glossolalia AE Glossolalia AE is a speech disorder AE that is the fluid vocalizing of speech-like syllables that lack any readily comprehended meaning. WEB: http://en.wikipedia.org/wiki/Glossolalia JX, LW, YH 语言不清 leg pain AE 10024130 JX, LW, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003182.htm 腿痛 Leg pain AE is a pain AE that is a common problem in leg, it can be due to a cramp, injury, or other cause. stomach ache AE 10042126 NCIt: C26682 胃痛 abdominal pain AE stomach pain AE stomachache AE CTCAE: E10460 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Abdominal_pain http://www.nhs.uk/conditions/stomach-ache-abdominal-pain/Pages/Introduction.aspx Stomachache AE is a pain AE that the pain in or near your stomach. It is a common symptom associated with transient disorders or serious disease. conduction block AE 传导阻滞 Conduction block AE is a conduction system disorder AE that shows failure of impulse transmission at some point along a nerve fiber, although conduction along the segments proximal and distal to it are unaffected. JX, LW, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=10757 photodermatitis AE WEB: http://en.wikipedia.org/wiki/Photodermatitis 光敏性皮炎 Photodermatitis AE is a dermatitis AE that referred to as sun poisoning or photoallergy, is a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. JX, LW, YH pygalgia AE WEB: http://www.medilexicon.com/medicaldictionary.php?t=74312 JX, LW, YH Pygalgia AE is a pain AE that is a rarely used term meaning pain in the buttocks. 臀痛 throat irritation AE 10043521 throat discomfort AE WEB: http://en.wikipedia.org/wiki/Throat_irritation 咽喉不适 Throat irritation AE is a discomfort AE that refers to a dry cough, a scratchy feeling at the back of the throat, or a sensation of a lumpy feeling or something stuck at the back of the throat. JX, LW, YH interstitial nephritis AE 10048302 tubulointerstitial nephritis AE Interstitial nephritis AE is an inflammation AE that is a form of nephritis affecting the interstitium of the kidneys surrounding the tubules. This disease can be either acute, meaning it occurs suddenly, or chronic, meaning it is ongoing and eventually ends in kidney failure. 间质肾炎 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Interstitial_nephritis hoarseness AE 10020201 CTCAE:E13384 NCIt:C47813 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003054.htm Hoarseness AE is a hoarseness AE that refers to a difficulty making sounds when trying to speak. Vocal sounds may be weak, breathy, scratchy, or husky, and the pitch or quality of the voice may change. 声音嘶哑 JX, LW, YH, MW photosensitization AE 光敏 JX, LW, YH Photosensitization AE is a hypersensitivity AE that refers to development of abnormally heightened reactivity of the skin or eyes to sunlight. WEB: http://medical-dictionary.thefreedictionary.com/photosensitization fanconi syndrome AE 10016219 JX, LW, YH 范可尼综合征 WEB: http://en.wikipedia.org/wiki/Fanconi_syndrome Fanconi syndrome AE is a kidney AE that is a disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine, instead of being reabsorbed. keratoconjunctivitis AE 10023348 角膜结膜炎 Keratoconjunctivitis AE is an inflammation AE that is inflammation of the cornea and conjunctiva. When only the cornea is inflamed, it is called keratitis; when only the conjunctiva is inflamed, it is called conjunctivitis. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Keratoconjunctivitis hepatic insufficiency AE 10056542 JX, LW, YH Hepatic insufficiency AE is a liver disorder AE that shows a failure or partial failure of normal liver function. 肝功能不全 WEB: http://medical-dictionary.thefreedictionary.com/hepatic+insufficiency hypoxemia AE 10021142 低血氧症 WEB: http://en.wikipedia.org/wiki/Hypoxemia JX, LW, YH Hypoxemia AE is a blood gas investigation result abnormal AE that is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. irritant contact dermatitis AE 刺激性接触性皮炎 JX, LW, YH Irritant contact dermatitis AE is a dermatitis AE that is a form of contact dermatitis that can be divided into forms caused by chemical irritants and those caused by physical irritants. WEB: http://en.wikipedia.org/wiki/Irritant_contact_dermatitis pitting edema AE 10054547 Pitting edema AE is an edema AE that shows observable swelling of body tissues due to fluid accumulation that may be demonstrated by applying pressure to the swollen area (such as by depressing the skin with a finger). 指压性水肿 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=88528 JX, LW, YH acute bronchitis AE 10000687 Acute bronchitis AE is a bronchitis AE that is an inflammation of the large bronchi (medium-size airways) in the lungs that is usually caused by viruses or bacteria and may last several days or weeks. Characteristic symptoms include cough, sputum (phlegm) production, and shortness of breath and wheezing related to the obstruction of the inflamed airways. WEB: http://en.wikipedia.org/wiki/Acute_bronchitis JX, LW, YH 急性支气管炎 renal calculus AE 10038385 10038386 renal calculi AE NCIt: C26807 Renal calculus AE is a kidney AE that is a solid concretion or crystal aggregation formed in the kidneys from minerals in the urine. Kidney stones typically leave the body by passage in the urine stream, and many stones are formed and passed without causing symptoms. If stones grow to sufficient size (usually at least 3 millimeters (0.12 in)) they can cause blockage of the ureter. This leads to pain, most commonly beginning in the flank or lower back and often radiating to the groin or genitals. 肾结石 kidney stone AE CTCAE: E13018 WEB: http://en.wikipedia.org/wiki/Kidney_stone nephrolithiasis AE JX, LW, YH clouding of consciousness AE brain fog AE JX, LW, YH Clouding of consciousness AE is a sensory capability AE that is a term used in conventional medicine denoting an abnormality in the "regulation" of the "overall level" of consciousness that is mild and less severe than a delirium. The sufferer experiences a subjective sensation of mental clouding described as feeling "foggy". mental fog AE WEB: http://en.wikipedia.org/wiki/Clouding_of_consciousness 意识模糊 reflex tachycardia AE 10063096 JX, LW, YH 反射性心动过速 Reflex tachycardia AE is a tachycardia AE that shows increased heart rate in response to some stimulus conveyed through the cardiac nerves. WEB: http://www.medilexicon.com/medicaldictionary.php?t=89526 joint sprain AE 10023229 JX, LW, YH Joint sprain AE is a joint disorder AE that is damage to one or more ligaments in a joint, often caused by trauma or the joint being taken beyond its functional range of motion. 关节扭伤 WEB: http://en.wikipedia.org/wiki/Sprain epicondylitis AE 10014971 WEB: http://en.wikipedia.org/wiki/Epicondylitis Epicondylitis AE is an inflammation AE that is a type of musculoskeletal disorder that refers to an inflammation of an epicondyle. 上髁炎 JX, LW, YH melanoglosia AE 10014971 Melanoglosia AE is a tongue AE that shows tongue turn black. Any blackening of the tongue associated with certain disorders and diseases in animals and humans. JX, LW, YH WEB: http://encyclopedia2.thefreedictionary.com/melanoglosia 舌黑 ventricular tachycardia AE 10047302 WEB: http://en.wikipedia.org/wiki/Ventricular_tachycardia NCIt: C50802 CTCAE: E10239 Ventricular tachycardia AE is a tachycardia AE that is a type of tachycardia, or a rapid heart beat that arises from improper electrical activity of the heart presenting as a rapid heart rhythm, that starts in the bottom chambers of the heart, called the ventricles. JX, LW, YH 心室性心搏过速 granulomatous hepatitis AE 肉芽肿性肝炎 Granulomatous hepatitis AE is a hepatitis AE that refers to an inflammatory liver disease associated with granuloma formation in the liver. JX, LW, YH WEB: http://radiopaedia.org/articles/granulomatous-hepatitis hypogeusia AE 10020989 WEB: http://en.wikipedia.org/wiki/Hypogeusia 味觉减弱 JX, LW, YH Hypogeusia AE is a gustatory system AE that is a reduced ability to taste things (to taste sweet, sour, bitter, or salty substances). dysphoria AE 10013954 烦躁不安 JX, LW, YH Dysphoria AE is a behavior and neurological AE that is a profound state of unease or dissatisfaction. In a psychiatric context, dysphoria may accompany depression, anxiety, or agitation. Common reactions to dysphoria include emotional distress or indifference. WEB: http://en.wikipedia.org/wiki/Dysphoria oneirism AE 10030332 Oneirism AE is a behavior and neurological AE that is a state of abnormal consciousness in which dream-like experiences and hallucinations happen while awake. WEB: http://en.wiktionary.org/wiki/oneirism JX, LW, YH 梦幻症 podalgia AE JX, LW, YH 足痛 WEB: http://en.wiktionary.org/wiki/podalgia Podalgia AE is a pain AE that shows pain in the foot. brachialgia AE 10068901 WEB: http://en.wiktionary.org/wiki/brachialgia Brachialgia AE is a pain AE that shows pain in the arm. JX, LW, YH 臂痛 coxalgia AE 10011249 WEB: http://en.wiktionary.org/wiki/coxalgia JX, LW, YH 髋痛 Coxalgia AE is a pain AE that shows pain in the hip. limb injury AE 10061225 肢体伤 JX, LW, YH Limb injury AE is an injury AE which involve damage to bones, joints, ligament, musles, the major blood vessels and nerves of the limb. polymyalgia rheumatica AE 10036099 Polymyalgia rheumatica AE is a muscle pain AE that is a syndrome with pain or stiffness, usually in the neck, shoulders, and hips. The pain can be very sudden, or can occur gradually over a period. It may be caused by an inflammatory condition of blood vessels such as temporal arteritis. WEB: http://en.wikipedia.org/wiki/Polymyalgia_rheumatica 风湿性多发性肌痛 JX, LW, YH fibromyalgia AE 10048439 纤维肌痛 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Fibromyalgia Fibromyalgia AE is a muscle pain AE that is characterised by chronic widespread pain and allodynia (a heightened and painful response to pressure). Fibromyalgia symptoms are not restricted to pain, leading to the use of the alternative term fibromyalgia syndrome for the condition. Other symptoms include debilitating fatigue, sleep disturbance, and joint stiffness. hepatic encephalopathy AE 10019660 portosystemic encephalopathy AE Hepatic encephalopathy AE is an encephalopathy AE that is the occurrence of confusion, altered level of consciousness, and coma as a result of liver failure. In the advanced stages it is called hepatic coma or coma hepaticum. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hepatic_encephalopathy chorea AE 10008748 choreia AE WEB: http://en.wikipedia.org/wiki/Chorea JX, LW, YH 舞蹈症 a behavior and neurological AE AE that is an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias. nightmare AE 10029412 Nightmare AE is a sleep disorder AE that is an unpleasant dream that can cause a strong emotional response from the mind, typically fear or horror but also despair, anxiety and great sadness. 梦魇 WEB: http://en.wikipedia.org/wiki/Nightmare JX, LW, YH depersonalization AE 10012359 depersonalisation AE JX, LW, YH a psychiatric disorder AE that is an anomaly of self-awareness. It consists of a feeling of watching oneself act, while having no control over a situation. Subjects feel they have changed, and the world has become vague, dreamlike, less real, or lacking in significance. It can be a disturbing experience, since many feel that, indeed, they are living in a "dream". WEB: http://en.wikipedia.org/wiki/Depersonalization 人格解体 apatheia AE a psychiatric disorder AE that refers to a state of mind where one is not disturbed by the passions. apathia AE WEB: http://en.wikipedia.org/wiki/Apatheia 情感冷漠 JX, LW, YH parosmia AE 10034018 JX, LW, YH troposmia AE WEB: http://en.wikipedia.org/wiki/Parosmia cacosmia AE 味觉倒错 Parosmia AE is a sensory capability AE that is an olfactory dysfunction which is characterized by the inability of the brain to properly identify an odor’s “natural” smell. xerophthalmia AE 10048221 xerophthalmus AE Xerophthalmia AE is an eye AE that is a medical condition in which the eye fails to produce tears. WEB: http://en.wikipedia.org/wiki/Xerophthalmia JX, LW, YH 干眼病 chondropathy AE 10061762 JX, LW, YH 软骨病 WEB: http://en.wikipedia.org/wiki/Chondropathy Chondropathy AE is a bone disorder AE that refers to a disease of the cartilage. It is frequently divided into 5 grades, with 0-2 defined as normal, and 3-4 defined as diseased. teratogenesis AE Teratogenesis AE is a female reproductive system AE that is a prenatal toxicity characterized by structural or functional defects in the developing embryo or fetus. It also includes intrauterine growth retardation, death of the embryo or fetus, and transplacental carcinogenesis. WEB: http://www.britannica.com/EBchecked/topic/587782/teratogenesis JX, LW, YH 畸胎 premature atrial contraction AE 10056964 Premature atrial contraction AE is an arrhythmia AE that is a common cardiac dysrhythmia characterized by premature heartbeats originating in the atria. WEB: http://en.wikipedia.org/wiki/Premature_atrial_contraction 早搏 atrial premature complexes AE atrial premature beats AE JX, LW, YH parotitis AE 10034038 WEB: http://en.wikipedia.org/wiki/Parotitis An inflammation AE that courrs in one or both parotid glands, the major salivary glands located on either side of the face, in humans. The parotid gland is the salivary gland most commonly affected by inflammation. 腮腺炎 JX, LW, YH glossitis AE 10018386 舌炎 WEB: http://en.wikipedia.org/wiki/Glossitis Glossitis AE is an inflammation AE that can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal surface of the tongue, leaving a smooth and erythematous surface. JX, LW, YH genital edema AE 10018146 生殖器水肿 CTCAE:E13111 JX, LW, YH, MW WEB: http://www.lymphoedemanz.org.nz/About+Lymphoedema/Genital+Oedema.html NCIt:C78324 Genital edema AE is an edema AE that can be the result of interruption to the lymphatic drainage of this area caused by tumor, surgical removal of lymph nodes, radiotherapy or infection. Congenital disorders causing inadequate lymphatics can sometimes lead to the development of this condition. orgasm incapacity AE Orgasm incapacity AE is a reproductive system AE that the disorder characterized by an inability to achieve orgasm. JX, LW, YH 缺乏性高潮 sedation AE 10039897 镇静 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sedation Sedation AE is a behavior and neurological AE that is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. sinus bradycardia AE 10040741 WEB: http://en.wikipedia.org/wiki/Sinus_bradycardia CTCAE: E10208 Sinus bradycardia AE is a bradycardia AE that is a heart rhythm that originates from the sinus node and has a rate that is lower than normal. In humans, bradycardia is generally defined to be a rate of under 60 beats per minute. JX, LW, YH NCIt: C26923 窦性心动过缓 cardiac output decreased AE 10007595 WEB: http://www1.us.elsevierhealth.com/MERLIN/Gulanick/archive/Constructor/gulanick10.html http://en.wikipedia.org/wiki/Cardiac_output JX, LW, YH 心输出量减少 Cardiac output decreased AE is a cardiac disorder AE that shows a state in which the blood pumped by an individual's heart is sufficiently reduced that it is inadequate to meet the needs of the body's tissues. Cardiac output is the volume of blood being pumped by the heart, in particular by a left or right ventricle in the time interval of one minute. steatorrhea AE 10041968 脂溢 steatorrhoea AE Steatorrhea AE is a digestive system AE that is the presence of excess fat in feces. Stools may also float due to excess lipid, have an oily appearance and can be especially foul-smelling. JX, LW, YH WEB: http://en.wikipedia.org/wiki/Steatorrhea malabsorption syndrome AE 10025479 吸收不良综合症 JX, LW, YH Malabsorption syndrome AE is a digestive system AE that refers to a number of disorders in which the intestine’s ability to absorb certain nutrients, such as vitamin B12 and iron, into the bloodstream is negatively affected. WEB: http://www.healthline.com/health/malabsorption#Overview1 sialadenitis AE 10040627 Sialadenitis AE is an inflammation AE that is inflammation of a salivary gland. It may be subdivided temporally into acute, chronic and recurrent forms. 唾液腺炎 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Sialadenitis parkinson's disease AE 10061536 帕金森综合症 paralysis agitans AE WEB: http://en.wikipedia.org/wiki/Parkinson's_disease hypokinetic rigid syndrome AE choreia AE a nervous system AE that shows a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain, the cause of this cell death is unknown. JX, LW, YH idiopathic/primary parkinsonism AE urinary calculus AE 10046531 WEB: http://www.merckmanuals.com/professional/genitourinary_disorders/urinary_calculi/urinary_calculi.html 尿结石 JX, LW, YH urinary calculi AE Urinary calculus AE a urinary system AE that is solid particles in the urinary system. They may cause pain, nausea, vomiting, hematuria, and, possibly, chills and fever due to secondary infection. sinoatrial block AE 10040736 Sinoatrial block AE is a conduction system disorder AE that shows the electrical impulse is delayed or blocked on the way to the atria, thus delaying atrial depolarization. 窦房阻滞 WEB: http://en.wikipedia.org/wiki/Sinoatrial_block JX, LW, YH hyperthyroidism AE 10020850 CTCAE: E10322 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Hyperthyroidism 甲状腺机能亢进 NCIt: C3123 Hyperthyroidism AE is an endocrine system AE that is a condition in which the thyroid gland produces and secretes excessive amounts of the free (not protein bound circulating in the blood) thyroid hormones -triiodothyronine (T3) and/or thyroxine (T4). akathisia AE 10001540 CTCAE:E12581 静坐困难 WEB: http://en.wikipedia.org/wiki/Akathisia NCIt:C78163 JX, LW, YH, MW Akathisia AE is a behavior and neurological AE that is a movement disorder characterized by a feeling of inner restlessness and a compelling need to be in constant motion, as well as by actions such as rocking while standing or sitting, lifting the feet as if marching on the spot, and crossing and uncrossing the legs while sitting. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace. acathisia AE retinopathy AE 10038923 JX, LW, YH CTCAE: E10432 WEB: http://en.wikipedia.org/wiki/Retinopathy NCIt: C62601 Retinopathy AE is an eye AE that is due to persistent or acute damage to the retina of the eye. Ongoing inflammation and vascular remodeling may occur over periods of time where the patient is not fully aware of the extent of the disease. Frequently, retinopathy is an ocular manifestation of systemic disease as seen in diabetes or hypertension. 视网膜病变 sinus arrest AE 10040738 sinoatrial arrest AE sinus pause AE 窦性停搏 Sinus arrest AE is an arrhythmia AE that is a medical condition wherein the sinoatrial node of the heart transiently ceases to generate the electrical impulses that normally stimulate the myocardial tissues to contract and thus the heart to beat. It is defined as lasting from 2.0 seconds to several minutes. WEB: http://en.wikipedia.org/wiki/Sinoatrial_arrest JX, LW, YH ST segment depression AE 10041892 JX, LW, YH ST段下降 WEB: http://en.wikipedia.org/wiki/ST_depression ST segment depression AE is an electrocardiogram result abnormal AE that refers to a finding on an electrocardiogram. It may be determined by measuring the vertical distance between the patient's trace and the isoelectric line at a location 2-3 millimeters from the QRS complex. It is significant if it is more than 1 mm in V5-V6, or 1.5 mm in AVF or III. T-wave inversion AE 10042966 WEB: http://en.wikipedia.org/wiki/T_wave JX, LW, YH T-wave inversion AE is an electrocardiogram result abnormal AE that can be a sign of coronary ischemia, Wellens' syndrome, left ventricular hypertrophy, or CNS disorder. In electrocardiography, the T wave represents the repolarization (or recovery) of the ventricles. T波倒置 hyperthermia AE 10020843 体温过高 JX, LW, YH, SJ WEB: http://en.wikipedia.org/wiki/Hyperthermia Hyperthermia AE is an abnormal body temperature AE that is elevated body temperature due to failed thermoregulation that occurs when a body produces or absorbs more heat than it dissipates. Extreme temperature elevation then becomes a medical emergency requiring immediate treatment to prevent disability or death. priapism AE 10036661 JX, LW, YH Priapism AE a male reproductive system AE that is a potentially painful medical condition in which the erect penis does not return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours. 阴茎持续勃起 WEB: http://en.wikipedia.org/wiki/Priapism gingival bleeding AE 10018276 bleeding on probing AE WEB: http://en.wikipedia.org/wiki/Bleeding_on_probing Gingival bleeding AE is a hemorrhage AE that is a term used by dentists and dental hygienists when referring to bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus, or interface between the gingiva and a tooth. Bleeding on probing, often abbreviated BOP, is a sign of inflammation and indicates some sort of destruction and erosion to the lining of the sulcus or the ulceration of sulcular epithelium. The blood comes from lamina propria after the ulceration of the lining. 牙龈出血 bleeding gums AE JX, LW, YH hearing loss AE 10019245 10019246 hearing impairment AE a hearing disorder AE that is a partial or total inability to hear. In children it may affect the development of language and can cause work related difficulties for adults. CTCAE: E10276 WEB: http://en.wikipedia.org/wiki/Hearing_loss JX, LW, YH hearing impaired AE anacusis AE NCIt: C50576 听力下降 deafness AE hard of hearing AE muscle fatigue AE 10049565 physical fatigue AE Muscle fatigue AE is a muscle adverse event that is the decline in ability of a muscle to generate force. It can be a result of vigorous exercise but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction. WEB: http://en.wikipedia.org/wiki/Muscle_fatigue 肌肉疲劳 JX, LW, YH regurgitation AE 10067171 http://en.wikipedia.org/wiki/Regurgitation_%28digestion%29 Regurgitation AE is a digestive system AE that is the expulsion of material from the pharynx, or esophagus, usually characterized by the presence of undigested food or blood. JX, LW, YH 反胃 skin irritation AE 10040880 JX, LW, YH Skin irritation AE is a skin AE that is a mild inflammatory dermal tissue reaction, it can be caused by physical contact with an irritant or can be a local response to a systemic trigger. 皮肤刺激 herpes simplex AE 10019948 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Herpes_simplex herpes catarrhalis AE a herpes viral infection AE tha is caused by both Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). 单纯疱疹 measles AE 10027011 Measles AE is a viral infection AE is an infection of the respiratory system, immune system and skin caused by a virus, specifically a paramyxovirus of the genus Morbillivirus. WEB: http://en.wikipedia.org/wiki/Measles 麻疹 English measles AE rubeola AE morbilli AE JX, LW, YH hypercholesteremia AE 10005425 10008661 10020604 JX, LW, YH cholesterol high AE hypercholesterolemia AE dyslipidemia WEB: http://en.wikipedia.org/wiki/Hypercholesterolemia 高胆固醇血症 Hypercholesteremia AE is a blood cholesterol abnormal AE that is the presence of high levels of cholesterol in the blood. toxic epidermal necrolysis AE 10044223 中毒性表皮坏死溶解症 WEB: http://en.wikipedia.org/wiki/Toxic_epidermal_necrolysis Toxic epidermal necrolysis AE is a skin AE that is a rare, life-threatening skin condition which is usually caused by a reaction to drugs. Lyell's syndrome AE NCIt:C79777 JX, LW, YH, MW CTCAE:E13743 atrioventricular junctional rhythm AE JX, LW, YH Atrioventricular junctional rhythm AE is an arrhythmia AE that is an electrocardiographic finding in which the pacer of the heart is located in the AV junction, presenting with a narrow QRS complex and a rate of 40-60 beats per minute. 房室交界性心律 unconsciousness AE 10045481 Unconsciousness AE is a sensory capability AE that is a state which occurs when the ability to maintain a awareness of self and environment is lost, it involves a complete or near-complete lack of responsiveness to people and other environmental stimuli. WEB: http://en.wikipedia.org/wiki/Unconsciousness JX, LW, YH loss of consciousness AE 意识丧失 pemphigus AE 10034280 天疱疮 Pemphigus AE is a skin AE that is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. WEB: http://en.wikipedia.org/wiki/Pemphigus JX, LW, YH onychomycosis AE tinea unguium AE dermatophytic onychomycosis AE WEB: http://en.wikipedia.org/wiki/Onychomycosis JX, LW, YH 甲癣 Onychomycosis AE is a nail infection AE that is a fungal infection of the nail. It is the most common disease of the nails and constitutes about half of all nail abnormalities. miosis AE 10027646 Miosis AE is an eye AE that is a term with various definitions, which generally include constriction of the pupil. 瞳孔缩小 myosis AE WEB: http://en.wikipedia.org/wiki/Miosis JX, LW, YH optic atrophy AE 10030910 JX, LW, YH 视神经萎缩 an optic neuropathy AE that shows the loss of some or most of the nerve fibers in the optic nerve. The effects range from visual change to severe visual loss. WEB: http://www.kellogg.umich.edu/patientcare/conditions/optic.atrophy.html albuminuria AE 10001580 WEB: http://en.wikipedia.org/wiki/Albuminuria 蛋白尿 JX, LW, YH Albuminuria AE is a urine abnormality AE that is a pathological condition wherein albumin is present in the urine. It is a type of proteinuria. enuresis AE 10014928 JX, LW, YH Enuresis AE is a urine abnormality AE that refers to a repeated inability to control urination. Use of the term is usually limited to describing individuals old enough to be expected to exercise such control. 遗尿 This term appears to be a synonym to the 'urinary incontinence AE'. WEB: http://en.wikipedia.org/wiki/Enuresis gum hypertrophy AE 10018781 gingival enlargement AE gingival over-growth AE gingival hyperplasia AE WEB: http://en.wikipedia.org/wiki/Gingival_enlargement hypertrophic gingivitis AE 牙龈增生 Gum hypertrophy AE is a digestive system AE that is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications. gingival hypertrophy AE JX, LW, YH contact dermatitis AE 10010790 Contact dermatitis AE is a dermatitis AE that is a type of skin inflammation.It results from exposure to allergens (allergic contact dermatitis) or irritants (irritant contact dermatitis). Phototoxic dermatitis occurs when the allergen or irritant is activated by sunlight. JX, LW, YH 接触性皮炎 WEB: http://en.wikipedia.org/wiki/Contact_dermatitis necrotizing vasculitis AE 10028892 坏死性血管炎 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000432.htm JX, LW, YH Necrotizing vasculitis AE is a vasculitis AE that is a rare condition which involves inflammation of the blood vessel walls. carpal tunnel syndrome AE 10007697 Carpal tunnel syndrome AE is a peripheral neuropathy AE that is a median entrapment neuropathy that causes paresthesia, pain, numbness, and other symptoms in the distribution of the median nerve due to its compression at the wrist in the carpal tunnel. WEB: http://en.wikipedia.org/wiki/Carpal_tunnel_syndrome JX, LW, YH WEB: http://emedicine.medscape.com/article/1141168-clinical#showall 腕管综合征 median nerve neuropathy AE erythromelalgia AE 10015284 Mitchell's disease AE Erythromelalgia AE is a peripheral arterial disease AE that is a rare neurovascular peripheral pain disorder in which blood vessels, usually in the lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and inflamed. red neuralgia AE acromelalgia AE WEB: http://en.wikipedia.org/wiki/Erythromelalgia erythermalgia AE 红斑性肢痛症 JX, LW, YH Raynaud's syndrome AE 10037914 雷诺综合症 a syndrome AE which results in the Raynaud's syndrome, a rare disease causes some areas of your body — such as your fingers and toes — to feel numb and cold in response to cold temperatures or stress. In Raynaud's disease, smaller arteries that supply blood to your skin narrow, limiting blood circulation to affected areas (vasospasm). Raynaud's phenomenon AE WEB: http://www.mayoclinic.org/diseases-conditions/raynauds-disease/basics/definition/con-20022916 JX, LW, YH Raynaud's disease AE extrapyramidal syndrome AE 10015836 JX, LW, YH extrapyramidal side effects AE 椎体外系综合征 Extrapyramidal syndrome AE is a nervous system AE that is drug induced movement disorders which include acute and tardive symptoms. vertebral body outside the beam syndrome AE WEB: http://en.wikipedia.org/wiki/Extrapyramidal_symptoms sodium retention AE 10041277 钠潴留 WEB: https://answers.yahoo.com/question/index?qid=20100823074826AAcg7WV JX, LW, YH an electrolyte lab test abnormal AE that is when the kidneys hold on to more sodium and do not excrete it with the kidneys. This tends to expand the blood volume, which can elevate the blood pressure. complex regional pain syndrome AE 10064332 WEB: http://www.mayoclinic.org/diseases-conditions/complex-regional-pain-syndrome/basics/definition/con-20022844 Complex regional pain syndrome typically develops after an injury, surgery, stroke or heart attack, but the pain is out of proportion to the severity of the initial injury. SJ, YH complex regional pain syndrome AE is a pain AE that results in an uncommon form of chronic pain that usually affects an extremity. sciatica AE 10039674 坐骨神经痛 WEB: http://en.wikipedia.org/wiki/Sciatica sciatic neuralgia AE lumbar radiculopathy AE Sciatica AE is a pain AE that is a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve or by compression or irritation of the left or right or both sciatic nerves. sciatic neuritis AE JX, LW, YH joint stiffness AE 10023230 WEB: http://en.wikipedia.org/wiki/Joint_stiffness JX, LW, YH Joint stiffness AE is a joint disorder AE that may be either the symptom of pain on moving a joint, the symptom of loss of range of motion or the physical sign of reduced range of motion. 关节僵硬 breast engorgement AE 10006240 Breast engorgement AE is a reproductive system AE that occurs in the mammary glands due to expansion and pressure exerted by the synthesis and storage of breast milk. 乳房充盈 WEB: http://en.wikipedia.org/wiki/Breast_engorgement JX, LW, YH nervous tension AE 10029214 JX, LW, YH 神经紧张 Nervous tension AE is a behavior and neurological AE that might be said to be a physical expression of how people deal with negatively experienced emotion. WEB: http://helpmetosleep.org/featured-articles/how-to-relieve-nervous-tension/ nervousness AE 10029216 JX, LW, YH 神经过敏 Nervousness AE is a behavior and neurological AE that shows an uneasy psychological state which including anxiety, neurosis, neuroticism, and worry, etc. WEB: http://en.wikipedia.org/wiki/Nervousness osteoarthritis AE 10031161 Osteoarthritis AE is an arthritis AE that is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Osteoarthritis is not an inflammatory disease even-though the name suggest one. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. degenerative joint disease AE JX, LW, YH 骨关节炎 WEB: http://en.wikipedia.org/wiki/Osteoarthritis degenerative arthritis AE osteoarthrosis AE methemoglobinemia AE 10027506 JX, LW, YH methaemoglobinaemia AE Methemoglobinemia AE is a red blood cell profile abnormal AE that is a disorder characterized by the presence of a higher than normal level of methemoglobin (metHb, i.e., ferric [Fe3+] rather than ferrous [Fe2+] haemoglobin) in the blood. It's a form of hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to bind oxygen. WEB: http://en.wikipedia.org/wiki/Methemoglobinemia 高铁血红蛋白症 hemiageusia AE 偏侧味觉缺失 WEB: http://www.medilexicon.com/medicaldictionary.php?t=39885 hemigeusia AE hemiageustia AE JX, LW, YH Hemiageusia AE is a ageusia AE that shows loss of taste from one side of the tongue. skin swelling AE 10053262 Skin swelling AE is an edema AE that has an outcome of the occurrence of swelling which is located on the skin. 胕肿 JX, LW, YH WEB: http://www.rightdiagnosis.com/sym/skin_swelling.htm fibrosing alveolitis AE 10016640 纤维化肺泡炎 WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1818528/ JX, LW, YH Fibrosing alveolitis AE is a lung inflammation AE that is a disease of unknown cause mainly involving the gas-exchanging portions of the lungs. It may occur in isolation and be called cryptogenic or idiopathic, in which case the clinical manifestations are mainly respiratory, or it may be associated with other disorders, such as rheumatoid arthritis. hypochloremic alkalosis AE 10020958 低氯性碱中毒 an electrolyte chloride abnormal AE where the patient's body has abnormally low levels of chloride. This condition usually results from an extremely high loss of chloride, rather than a low intake of it. JX, LW, YH WEB: http://www.wisegeek.com/what-is-hypochloremic-alkalosis.htm erythema annulare centrifugum AE MedDRA: 10015154 deep gyrate erythema AE Erythema annulare centrifugum AE is an erythema AE that is a descriptive term for a skin lesion. The lesions form consists of redness (erythema) in a ring form (anulare) that spreads from the center (centrifugum). JX, LW, YH erythema perstans AE superficial gyrate erythema AE 离心性环形红斑 palpable migrating erythema AE WEB: http://en.wikipedia.org/wiki/Erythema_annulare_centrifugum irritation AE 10029216 Irritation is a behavior and neurological AE that is a state of inflammation or painful reaction to allergy or cell-lining damage. WEB: http://en.wikipedia.org/wiki/Irritation 刺激 JX, LW, YH neuroticism AE 神经质 JX, LW, YH a psychiatric disorder AE that is a fundamental personality trait in the study of psychology characterized by anxiety, fear, moodiness, worry, envy, frustration, jealousy, and loneliness. WEB: http://en.wikipedia.org/wiki/Neuroticism hyperirritability AE This term appears to be a synonym to the 'irritability AE'. JX, LW, YH Hyperirritability AE is a behavior and neurological AE that shows abnormally great or uninhibited response to stimuli. 过激 WEB: http://www.merriam-webster.com/medical/hyperirritability; http://en.wikipedia.org/wiki/Irritability rhinostenosis AE Rhinostenosis AE is a respiratory system AE that shows narrowing or obliteration of the nasal airway by scar formation JX, LW, YH WEB: http://www.drugs.com/dict/rhinostenosis.html 鼻道狭窄 sino-auricular heart-block AE Sino-auricular heart-block AE is a conduction system disorder AE that refers to a rare heart condition caused by abnormalities in the heart's electrical system rather than arterial disease. WEB: http://www.rightdiagnosis.com/s/sino_auricular_heart_block/intro.htm JX, LW, YH 窦房传导阻滞 anisosphygmia AE JX, LW, YH 脉搏不规则 Anisosphygmia AE is a cardiovascular disorder AE that shows difference in volume, force, or time of the pulse in the corresponding arteries on two sides of the body, the two radials, or femorals. WEB: http://www.medilexicon.com/medicaldictionary.php?t=4352 rubefaction AE JX, LW, YH WEB: http://www.medilexicon.com/medicaldictionary.php?t=79112 发红 Rubefaction AE is a skin AE that refers to erythema of the skin caused by local application of a counterirritant. myodystony AE JX, LW, YH 肌张力不全 Myodystony AE is an abnormal muscle tone AE that refers to a condition of slow relaxation, interrupted by a succession of slight contractions, following electrical stimulation of a muscle. WEB: http://www.drugs.com/dict/myodystony.html allotriosmia AE 10029216 heterosmia AE Allotriosmia is a behavior and neurological AE that shows incorrect recognition of odors. JX, LW, YH 嗅觉异常 WEB: http://www.medilexicon.com/medicaldictionary.php?t=2401 pharyngotonsillitis AE 10049140 WEB: http://www.persify.com/en/perspectives/medical-conditions-diseases/pharyngotonsillitis-_-951000101807 Pharyngotonsillitis is an inflammation AE that is a medical condition characterized by an inflammation of both the tonsils and the pharynx (located at the back of the throat). It occurs due to viral or bacterial infections. 咽扁桃体炎 JX, LW, YH hypersensitivity pneumonitis AE 10015887 Hypersensitivity pneumonitis AE is a pneumonia AE that is an inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. Sufferers are commonly exposed to the dust by their occupation or hobbies. WEB: http://en.wikipedia.org/wiki/Hypersensitivity_pneumonitis extrinsic allergic alveolitis AE JX, LW, YH 过敏性肺炎 stagger AE 蹒跚 JX, LW, YH WEB: http://en.wiktionary.org/wiki/stagger Stagger AE is a movement disorder AE that shows an unsteady movement of the body in walking or standing, as if one were about to fall. myocardial anoxia AE JX, LW, YH 心肌缺氧 Myocardial anoxia AE is a hypoxia AE that shows a reduced concentration of O2 in the myocardium. biliary colic AE 10004663 Biliary colic AE is a pain AE that is the term used to describe a type of pain related to the gallbladder that occurs when a gallstone transiently obstructs the cystic duct and the gallbladder contracts. cholecystalgia AE 胆绞痛 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Biliary_colic hyperemia AE WEB: http://en.wikipedia.org/wiki/Hyperaemia 充血 JX, LW, YH hyperaemia AE Hyperemia AE is a cardiovascular disorder AE that is the increase of blood flow to different tissues in the body. It can have medical implications, but is also a regulatory response, allowing change in blood supply to different tissues through vasodilation. tenderness AE 10043224 WEB: http://www.oxforddictionaries.com/us/definition/american_english/tenderness a sensory capability AE that has an outcome increased sensitivity to pain in a patient RR induration AE 10060708 RR WEB: http://www.merriam-webster.com/medical/induration a skin AE with the outcome of induration, which is an increase in the fibrous elements in tissue commonly associated with inflammation and marked by loss of elasticity and pliability or a hardened mass or formation foreign body sensation in eyes AE 10051116 WEB: http://www.richmondeye.com/eyehealth_foreignbody/ RR an eye AE which has an outcome of a foreign body sensation in the eye, or the sensation that something is in or scratching the eye injection site cellulitis AE 10050057 a cellulititis AE that occurs at an injection-site. RR WEB: http://www.nhs.uk/Conditions/Cellulitis/Pages/Symptoms.aspx peripheral coldness AE 10034568 a sensory capability AE that has an outcome of peripheral coldness, or coldness of extremeties WEB: http://www.patient.co.uk/leaflets/peripheral_coldness.htm RR hypoesthesia facial AE 10065312 a hypoaesthesia AE that has an outcome of a decrease in facial sensitivity RR WEB: http://www.webster-dictionary.org/definition/hypoesthesia hypoesthesia facial AE hypoaesthesia facial AE poor quality sleep AE 10062519 RR a sleep disorder AE that shows poor quality sleep vesicular rash AE 10037898 WEB: http://www.merriam-webster.com/medical/vesicular a rash AE characterized by the formation of vesicles rash vesicular AE RR limb discomfort AE 10061224 RR a discomfort AE that occurs at a limb scleral discoloration AE 10039696 scleral discolouration AE RR an eye disorder AE which has an outcome of discoloration of the sclera, or the whites of the eyes injection site urticaria AE 10022107 WEB: http://www.uptodate.com/contents/hives-urticaria-beyond-the-basics RR an urticaria AE that occurs in an injection site dysstasia AE 10050256 a behavior and neurological AE that results in dysstasia, or difficulty standing WEB: http://www.medilexicon.com/medicaldictionary.php?t=27458 RR hyperesthesia AE 10020568 a sensory capability AE that has an outcome of hyperaesthesia, meaning unusual or pathological sensitivity of the skin or of a particular sense RR 神经过敏 WEB: http://www.merriam-webster.com/dictionary/hyperesthesia hyperaesthesia AE nuclear magnetic resonance imaging spinal cord abnormal AE 10069585 a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the spinal cord RR ocular icterus AE 10058117 WEB: http://www.merriam-webster.com/dictionary/icterus RR an eye disorder AE which has an outcome of ocular icterus, or jaundice of the eye edema mouth AE 10030110 An edema AE that occurs in the mouth oedema mouth AE RR painful respiration AE 10033517 RR WEB: http://www.healthline.com/health/painful-respiration a respiratory system AE which has an outcome of painful respiration, an unpleasant sensation ranging from mild discomfort to unbearable agony while breathing ophthalmological examination abnormal AE 10056836 RR a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal ophthalmological examination ischemic optic neuropathy AE 10030924 optic ischemic neuropathy AE WEB: http://www.merckmanuals.com/professional/eye_disorders/optic_nerve_disorders/ischemic_optic_neuropathy.html WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/ RR an optic neuropahty AE which shows an infarction of the optic disk which presents as painless vision loss lyme disease AE 10025169 a bacterial infection AE with an outcome of Lyme disease, a tick-bourne illness cause by the bacterium B. burgdorferi that causes dermatologic, rheumatologic, neurologic, and cardiac abnormalities RR WEB: http://wwwn.cdc.gov/nndss/script/casedef.aspx?CondYrID=752&DatePub=1/1/2011 lymph node pain AE 10025182 a pain AE that has an outcome of lymph node pain NCIt: C78440 RR CTCAE: E10052 loss of control of legs AE 10024860 RR a movement disorder AE that has an outcome of loss of control of patient's legs livedo reticularis AE 10024648 RR WEB: http://www.merriam-webster.com/medical/livedo%20reticularis a vascular disorder AE that has an outcome of levedo reticularis, a condition of the peripheral blood vessels characterized by reddish blue mottling of the skin especially of the extremeties usually upon exposure to cold muscle strain AE 10050031 WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001109/ a muscle adverse event AE that has an outcome of muscle strain, which happens when a muscle is stretched too much and tears pulled muscle AE RR muscle tightness AE 10049816 RR WEB: http://www.chirocommunity.com/muscletightness.htm a muscle adverse event AE that has an outcome of muscle tightness, which is a tense feeling in muscles muscle rigidity AE 10028330 WEB: http://www.healthline.com/symptom/muscle-rigidity RR a muscle adverse event AE that has an outcome of muscle rigidity, a state of continuous firm, tense muscles with marked resistance to passive movement 肌肉僵硬 Miller Fisher syndrome AE 10049567 RR WEB: http://www.ninds.nih.gov/disorders/miller_fisher/miller_fisher.htm Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barre syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes type III immune complex mediated reaction AE 10053614 WEB: http://emedicine.medscape.com/article/136217-overview RR a hypersensitivity AE which has an outcome of type III immune complex mediated reaction, a type of hypersensitivity reaction in which circulating antigen-antibody immune complexes are deposited in post-capillary venules, with subsequent complement fixation tonsilar hypertrophy AE 10044003 WEB: http://www.cchi.com.hk/symposia/s3_ear_1.htm a tonsilitis AE with the outcome of tonsilar hypertrophy, or enlargement of the tonsils RR temperature intolerance AE 10057040 RR a sensory capability AE that results in temperature intolerance unresponsive to stimuli AE 10045555 RR a sensory capability AE that results in the patient being unresponsive to stimuli sputum discolored AE 10041806 a respiratory system AE that shows discolored sputum RR spinal column stenosis AE 10041540 a musculoskeletal system AE that has an outcome of spinal column stenosis, or narrowing of spaces in the spine that results in pressure on the spinal cord and/or nerve roots WEB: http://www.niams.nih.gov/Health_Info/Spinal_Stenosis/ RR skin tightness AE 10050637 a skin AE with the outcome of skin tightness RR ligament pain AE 10068790 a pain AE with the outcome of ligament pain RR idiopathic thrombocytopenic purpura AE 10021245 RR a thrombocytopenic purpura AE with no known cause (idiopathic). Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necesssary for normal blood clotting. Persons with this disorder have too few platelets in the blood. 特发性血小板减少性紫癜 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000535.htm cerebral palsy AE 10008129 A palsy AE that shows cerebral palsy, a disorder of movement, muscle tone, or posture that is caused by an insult to the immature, developing brain, most often before birth RR WEB: http://www.mayoclinic.org/diseases-conditions/cerebral-palsy/basics/definition/con-20030502 chronic inflammatory demyelinating polyradiculoneuropathy AE 10057645 RR a neurological AE with the outcome of chronic inflammatory demyelinating polyradiculoneuropathy, a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms caused by damage to the myelin sheath of the peripheral nerves WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm allergic dermatitis AE 10012434 an allergy AE which displays an allergic skin response following contact of an allergen, with the skin typically marked by an itchy red rash often accompanied by swelling and watery blisters. RR, JX, YH WEB: http://www.merriam-webster.com/dictionary/allergic%20contact%20dermatitis dermatitis allergic AE diet refusal AE 10012775 a behavior and neurological AE with an outcome of the patient refusing to eat RR blood pressure fluctuation AE 10005746 RR an abnormal blood pressure AE that has an outcome of blood pressure fluctuations aphagia AE 10049866 RR WEB: http://www.merriam-webster.com/medical/aphagia a digestive system AE which has an outcome of aphagia, which is the loss of the ability to swallow aphonia AE 10002953 a speech disorder AE with an outcome of aphonia, or loss of voice and of all but whispered speech WEB: http://www.merriam-webster.com/dictionary/aphonia NCIt:C79539 CTCAE:E12589 RR, MW abdominal pain lower AE 10000084 RR WEB: http://www.mayoclinic.org/symptoms/abdominal-pain/basics/definition/sym-20050728 a stomach pain AE that is observed in lower stomach abnormal sensation in eye AE 10000173 RR an eye AE with an outcome of an abnormal sensation in the eye impaired driving ability AE 10049564 RR a behavior and neurological AE which has an outcome of impaired driving ability increased bronchial secretion AE 10062530 a respiratory system AE that has an outcome of increased bronchial secretion, or an increase in the substance produced in the bronchial tree, which includes mucus, protein salts, plasma fluid, and proteins RR WEB: http://medical-dictionary.thefreedictionary.com/bronchial+secretion injection site streaking AE 10066778 RR WEB: http://www.bannerhealth.com/incfiles/housecalls/peds/FeverInfectionsCrying/ImmunizationReactions.htm an injection-site AE that displays injection site streaking, a red pattern on the skin localized to the injection site injection site vesicles AE 10022111 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003939.htm RR an injection-site AE that displays injection site streaking, which are small, fluid-filled blisters localized to the injection site international normalized ratio increased AE 10022402 10022595 NCIt: C78366 a lab test abnormal AE that has an outcome of an increased international normalized ratio, indicating an individual is more prone to bleeding INR increased AE WEB: http://circ.ahajournals.org/content/126/5/e52.full CTCAE: E12175 RR, MW, YH irregular sleep phase AE 10022995 RR a sleep disorder AE with the outcome of irregular sleep phase, which is an abnormality in the timing of sleep WEB: http://www.mayoclinic.org/diseases-conditions/delayed-sleep-phase/basics/definition/con-20035242 injection site anesthesia AE 10022047 an injection-site AE that displays injection site anesthesia, or numbness at the injection site RR injection site infection AE 10022076 RR WEB: http://www.merriam-webster.com/dictionary/infection an infection AE that occurs at an injection-site grip strength decreased AE 10062556 WEB: http://www.krepublishers.com/02-Journals/JLS/JLS-01-0-000-09-Web/JLS-01-1-000-09-Abst-PDF/JLS-01-01-057-09-020-Koley-S/JLS-01-01-057-09-020-Koley-S-Tt.pdf RR a behavior and neurological AE which has an outcome of decreased grip strength, or a reduction in the force applied by the hand to pull on or suspend from objects eyelid margin crusting AE 10052132 RR an eye AE with the outcome of eyelid margin crusting ear discomfort AE 10052137 WEB: http://www.merriam-webster.com/dictionary/discomfort RR an ear AE with the outcome of ear discomfort, an uncomfortable or painful feeling in the ear fecal incontinence AE 10016092 10016296 NCIt: C78498 RR, MW, YH CTCAE: E10693 faecal incontinence AE WEB: http://digestive.niddk.nih.gov/ddiseases/pubs/fecalincontinence/#what an abnormal defecation AE that has an outcome of fecal incontinence, the accidental passing of solid or liquid stool or mucus from the rectum fear AE 10016275 WEB: http://www.merriam-webster.com/dictionary/fear RR a behavior and neurological AE that has an outcome of fear, which is to be afraid and/or worried gingival pain AE 10018286 RR CTCAE: E10763 NCIt: C78325 a pain AE that has an outcome of pain in gums WEB: http://www.merriam-webster.com/dictionary/gingival glossitis AE 10018386 a tongue disorder with the outcome of glossitis, a condition in which the tongue is swollen and changes color, which may make the tongue appear smooth RR WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001053.htm muscle injury AE 10028314 an injury AE which has an outcome of muscle injury RR sensory disturbance AE 10040026 RR a sensory capability AE that has an outcome of sensory disturbance tracheal edema AE 10044296 an edema AE with an outcome of tracheal edema, which is the swelling of the airway between the throat and the lungs WEB: http://firstaidcalgary.ca/causes-of-tracheal-edema/ RR allergic eruption AE Allergic eruption AE is a skin AE that is most drug-induced cutaneous reactions, especially found in younger adults. Sometimes also be diagnosed with eczema. JX, LW, YH This term appears to be a synonym to the 'eczema AE'. 过敏性皮疹 erythrodermia AE 10037165 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Erythroderma Erythrodermia AE is a skin AE that is an inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface. 红皮病 exfoliative dermatitis AE red man syndrome AE dermatitis exfoliativa AE mycotic dermatitis AE 真菌性皮炎 Mycotic dermatitis is a dermatitis AE that is a inflammation of skin which induced by mycetes. JX, LW, YH peritendinitis symptom AE 腱鞘炎样症状 JX, LW, YH Peritendinitis symptom AE is an inflammation AE that has an outcome of inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced. orthostatic hypotension AE 10031127 orthostasis AE JX, LW, YH 直立性低血压 WEB: http://en.wikipedia.org/wiki/Orthostatic_hypotension postural hypotension AE Orthostatic hypotension AE is a hypotension AE that is a form of hypotension in which a person's blood pressure falls when suddenly standing up or stretching. In medical terms, it is defined as a fall in systolic blood pressure of at least 20 mm Hg or diastolic blood pressure of at least 10 mm Hg when a person assumes a standing position. color vision deficiency AE chromatopsia AE Color vision deficiency AE is an abnormal vision AE that is a group of conditions that affect the perception of color. They cause a range of changes in color vision, from mild difficulty with distinguishing shades to a total inability to detect color. These conditions are divided into three major categories: red-green color vision defects, blue-yellow color vision defects, and a complete absence of color vision. 色视力缺乏 WEB: http://ghr.nlm.nih.gov/condition/color-vision-deficiency JX, LW, YH carcinogenesis AE oncogenesis AE 致癌 WEB: http://en.wikipedia.org/wiki/Carcinogenesis Carcinogenesis AE is a tumor AE that is literally the 'creation' of cancer. It is a process by which normal cells are transformed into cancer cells. JX, LW, YH tumorigenesis AE anaphylactic shock AE 10002199 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=10092 WEB: http://smschile.cl/documentos/cursos2010/MedicalClinicsNorthAmerica/Acute%20Symptoms%20of%20Drug%20Hypersensitivity%20%28Urticaria,%20Angioedema,%20Anaphylaxis,%20Anaphylactic%20Shock%29.pdf a circulatory AE that is a serious allergic reaction associated with systemic vasodilation that causes low blood pressure which is by definition 30% lower than the person's baseline or below standard values. 过敏性休克 WEB: http://en.wikipedia.org/wiki/Anaphylaxis JX, LW, YH, RR pituitary adenomas AE JX, LW, YH WEB: http://en.wikipedia.org/wiki/Pituitary_adenoma Pituitary adenomas AE is a tumor AE that is a tumor which occur in the pituitary gland. Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas, with carcinomas accounting for 0.1% to 0.2%, approximately 35% being invasive adenomas and most being benign adenomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%. fatty infiltration AE 脂肪侵润 Fatty infiltration AE is an embolism AE that shows the abnormal accumulation of fat droplets in the cytoplasm of cells. WEB: http://dictionary.reference.com/browse/fatty+infiltration JX, LW, YH epigastric discomfort AE 10053155 JX, LW, YH 上腹部不适 WEB: http://www.rightdiagnosis.com/sym/epigastric_discomfort.htm Epigastric discomfort is a discomfort AE that shows discomfort in the upper central region of the abdomen. upper Abdominal discomfort AE acute intravascular hemolysis AE Acute intravascular hemolysis AE is a cardiovascular AE that has an outcome of disruption of red blood cells occurs while they are within blood vessels. JX, LW, YH 急性血管内溶血 allergic hepatitis AE 10071198 WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis Allergic hepatitis AE is a hepatitis AE that is a tissue-specific inflammatory diease caused by hepersensitivity to a particular drug, accomopanied by a systemic allergic reaction such as eosinophilia. JX, LW, YH 过敏性肝炎 paranoid anxietas AE WEB: http://en.wikipedia.org/wiki/Paranoid_anxiety Paranoid anxiety AE is a anxiety AE that is a term used in object relations theory, particularity in discussions about the Paranoid-schizoid and depressive positions. The term was frequently used by Melanie Klein, especially to refer to a pre-depressive and persecutory sense of anxiety characterised by the psychological splitting of objects. 偏执性焦虑 JX, LW, YH thrombotic thrombocytopenic purpura AE 10043648 WEB: http://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura CTCAE: E10061 Thrombotic thrombocytopenic purpura AE is a thrombocytopenic purpura AE that is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body. 血栓性血小板减少性紫癜 JX, LW, YH moschcowitz syndrome AE NCIt: C78797 glaucoma AE 10018304 Glaucoma AE is an eye AE that is a term describing a group of ocular (eye) disorders resulting in optic nerve damage or loss to the field of vision, in many patients caused by a clinically characterized pressure buildup in regards to the fluid of the eye (intraocular pressure-associated optic neuropathy). JX, LW, YH NCIt: C26782 青光眼 CTCAE: E10392 WEB: http://en.wikipedia.org/wiki/Glaucoma anaphylaxis AE 10002218 an allergy AE that shows a serious allergic reaction that is rapid in onset and may cause death. It typically causes a number of symptoms including an itchy rash, throat swelling, and low blood pressure. Common causes include insect bites and stings, foods, and medications. CTCAE: E11254 JX, LW, YH NCIt: C50460 过敏症 WEB: http://en.wikipedia.org/wiki/Anaphylaxis seasonal allergy AE 10048908 JX, LW, YH WEB: http://kidshealth.org/parent/medical/allergies/seasonal_allergies.html 季节性变态反应 an allergy AE which occur during certain times of the year, usually when outdoor molds release their spores, and trees, grasses, and weeds release tiny pollen particles into the air to fertilize other plants. hyponatremia AE 10021036 10021038 a blood sodium abnormal AE with an abnormally decreased sodium concentration in the blood hyponatraemia AE YH, MW CTCAE: E12339 WEB: http://www.mayoclinic.org/diseases-conditions/hyponatremia/basics/definition/con-20031445 NCIt: C37976 skin redness AE Skin redness AE is an erythema AE that is abnormal redness of the skin, often signaling a pathological condition, such as inflammation, infection, or sunburn. JX, LW, YH 皮肤发红 WEB: http://www.healthline.com/health/skin-redness angina AE 10002383 10008481 NCIt: C51221 DJ, SS, YH a chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood. chest pain - cardiac AE SIDER: C0002962 WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723 CTCAE: E10110 HPO: HP_0001681 tight chest AE aggravating angina AE an angina AE that is aggravating. JX, YH severe hypotension caused angina symptom aggravating AE 严重低血压导致心绞痛症状加重现象 JX, YH an aggravating angina AE that is caused by severe hypotension blink reflex abnormal AE 10058960 an eye AE that shows abnormal involuntary blinking of the eyelids corneal reflex abnormal AE 睑闭反射反常 JX, LW, YH URL: https://en.wikipedia.org/wiki/Corneal_reflex dazzling AE 目眩 Dazzling AE is a eye disorder AE that has an outcome of the consequence of illumination too intense for adaptation by the eye. In contrast to glare, dazzling is alleviated by appropriate tinted glasses. WEB: http://medical-dictionary.thefreedictionary.com/dazzling JX, LW, YH ventricular rhythm AE 10047297 JX, LW, YH 室性心律 Ventricular rhythm AE is an arrhythmia AE that shows the electrocardiographic finding of an ectopic ventricular rhythm with three or more consecutive ventricular premature beats with a rate less than 100 beats per minute. extrapyramidal signs AE JX, LW, YH 锥体外体征 Extrapyramidal signs AE is a nervous system AE that shows defects in basal ganglia function. It characterized by changes in muscle tone, poverty of voluntary movements (akinesia), or abnormal involuntary movements (dyskinesia). hearing disorder AE 10019243 JX, LW, YH Hearing disorder AE is an ear disorder that shows impairment of the sense of hearing. 听觉障碍 yellow urine AE 尿液呈黄色 Yellow urine AE is a urine abnormality AE that may be due to excretion of picric acid, dinitrophenol, phenacetin or chrysarobin or in alkaline pH, to increased secretion of anthocyanin, or associated with ingestion of beets or blackberries. Pure yellow urine is associated with increased acriflavine and has a green fluorescence; yellow-orange urine may be highly concentrated or contain increased bilirubin and biliverdin. JX, LW, YH epidermal necrosis AE 10059284 Epidermal necrosis AE is a necrosis AE that shows widespread keratinocyte cell death via apoptosis results in the tissue damage. JX, LW, YH 表皮坏死 arthromeningitis AE JX, LW, YH 滑膜炎 Arthromeningitis AE is an inflammation AE that shows inflammation of a synovial membrane, usually painful, particularly on motion, and characterized by fluctuating swelling, due to effusion in a synovial sac. pulmonary tuberculosis AE 10037440 JX, LW, YH Pulmonary tuberculosis AE is a lung disorder AE that is a contagious bacterial infection that involves the lungs. It may spread to other organs. WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000077.htm coronary heart disease AE 10068617 Coronary heart disease AE is a cardiovascular disorder AE that is a disease in which a waxy substance called plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle. JX, LW, YH WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/cad/ 冠心病 increased defecation frequency AE Increased defecation frequency AE is a abnormal stool AE that shows defecation number increased. 大便次数增加 JX, LW, YH symptomatic hypotension AE Symptomatic hypotension AE is a hypotension AE that shows blood pressure that less than 90/60 mm Hg with dizziness, vertigo etc. 症状性低血压 JX, LW, YH non-specific gastrointestinal dysfunction AE Non-specific gastrointestinal dysfunction AE is a gastrointestinal disorder AE that shows non-specific gastrointestinal dysfunction. 非特异性胃肠功能紊乱 JX, LW, YH abnormal sclerotin AE 骨质异常 JX, LW, YH Abnormal sclerotin AE is a bone disorder AE that shows abnormal sclerotin. fast and weak heart beat AE JX, LW, YH Fast and weak heart beat AE is a cardiac disorder AE that shows fast and weak heart beat. 心跳快而弱 pain over the liver AE JX, LW, YH 肝区痛 Pain over the liver AE is a pain AE that shows pain over the liver. increased biliary calculus AE 胆石增加 JX, LW, YH Increased biliary calculus AE is a liver, biliary, and pancreatic AE that shows increased biliary calculus. muscle function disorder AE 肌肉功能失调 Muscle function disorder AE is a muscle AE that shows muscle function disorder. JX, LW, YH accidental fall AE JX, LW, YH Accidental injury AE is a fall AE that shows accidental falls. 意外跌倒 accidental injury AE 10000380 意外损伤 JX, LW, YH Accidental injury AE is an injury AE that shows accidedntal injury. abnormal ejaculation AE 10000128 JX, LW, YH 异常射精 Abnormal ejaculation AE is a male reproductive system AE that shows abnormal ejaculation. distention of head AE Distention of head AE is a cardiovascular AE that shows distention of head. JX, LW, YH 头胀 water-sodium retention AE JX, LW, YH Water-sodium retention AE is an abnormal fluid regulation AE that shows water-sodium retention. 水钠潴留 WEB: http://www.livestrong.com/article/485782-sodium-retention-weight-gain/ dizziness when standing up AE 站起时头晕 Dizziness when standing up AE is a dizziness AE that shows dizziness when standing up. JX, LW, YH change of gustation AE Change of gustation AE is a gustatory system AE that shows the change of gustation. JX, LW, YH 味觉改变 vascular stimulation of pain AE 血管刺激性疼痛 Vascular stimulation of pain AE is a pain AE that shows pain which due to vascular stimulation. JX, LW, YH vascular pain AE 血管疼痛 JX, LW, YH Vascular pain AE is a pain AE that shows vascular pain. heaviness sense of arm AE Heaviness sense of arm AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the arm. JX, LW, YH 手臂沉重感 breast swelling AE 10006312 Breast swelling AE is an edema AE that is common for almost all women in the second half of their menstrual cycle. It in the premenstrual portion of the cycle can be mild to severe. 乳房肿胀 JX, LW, YH WEB: http://www.healthgrades.com/symptoms/breast-swelling gastrointestinal cramp AE 10049136 JX, LW, YH Gastrointestinal cramp AE is a muscle spasm AE that shows abnormal contractions of the gastrointestinal muscles. 肠胃痉挛 heart discomfort AE Heart discomfort AE is a discomfort AE that shows an uncomfortable feeling in the heart. 心脏不适 JX, LW, YH angiectopia of skin AE JX, LW, YH Angiectopia of skin AE a vascular disorder AE that shows abnormal position or course of a vessel in the skin. 皮肤血管异位 joint discomfort AE 关节不适 JX, LW, YH Joint discomfort AE is a discomfort AE that shows an uncomfortable feeling in the joint. eye discomfort AE JX, LW, YH 眼部不适 Eye discomfort AE is a discomfort AE that shows an uncomfortable feeling in the eye. instability of gait AE 步态不稳 Instability of gait AE is a abnormal gait AE that shows instability of gait. JX, LW, YH pemphigoid injury AE Pemphigoid injury AE is an injury AE that shows a skin disorder where one has large blisters on the skin. JX, LW, YH 类天疱疮样损伤 pulse frequency change AE Pulse frequency change AE is a cardiovascular AE that shows dpulse frequency change. 脉搏频率变化 JX, LW, YH pulse abnormal AE inhibition of myocardial contraction force AE Inhibition of myocardial contraction force AE is a cardiac disorder AE that shows inhibition of myocardial contraction force. JX, LW, YH 抑制心肌收缩力 decreased of atrial conduction velocity AE Decreased of atrial conduction velocity AE is a conduction system disorder AE that shows decreased of atrial conduction velocity. 心房传导速度减慢 JX, LW, YH spasm of lower limbs AE 下肢痉挛 JX, LW, YH Spasm of lower limbs AE is a muscle spasm AE that shows tightening and spasms of the muscles in the legs. electrocardiogram prolonged PR interval AE JX, LW, YH 心电图出现PR间期延长 Electrocardiogram prolonged PR interval AE is an electrocardiogram result abnormal AE that shows a prolonged time between the onset of atrial depolarization (P wave) to the beginning of ventricular depolarization (QRS complex). qrs wave broadening AE Qrs wave broadening AE is a electrocardiogram qrs complex abnormal AE that shows broadening qrs complex in the electrocardiogram. QRS波增宽 JX, LW, YH edema of lower limbs AE 下肢浮肿 JX, LW, YH Edema of lower limbs AE is an edema AE that shows enlargement of the leg, due to the accumulation of fluids. accelerated pulse AE 脉搏加快 Accelerated pulse AE is a cardiovascular AE that shows increased of the number of pulsations per minute palpable in an artery. JX, LW, YH bitter taste of mouth AE Bitter taste of mouth AE is a digestive system AE that is not from a bitter substance is a distorted sense of taste. A persistent bad taste in the mouth, whether bitter, metallic or foul, is called dysgeusia. JX, LW, YH WEB: http://www.healthgrades.com/symptoms/bitter-taste-in-mouth 口苦 skin irritant reaction AE Skin irritant reaction AE is a skin AE that shows rash, inflammation, swelling, scaling, or abnormal tissue which growth in the affected area. 皮肤刺激反应 JX, LW, YH vitreous suspended substance AE Vitreous suspended substance AE is an eye AE shows vitreous suspended substance in the eyes. JX, LW, YH 玻璃体悬浮物 dreaminess AE Dreaminess AE is a sleep disorder AE that shows dreaminess in the sleeping. JX, LW, YH 多梦 abdominal spasm AE 10051889 WEB: http://www.wisegeekhealth.com/what-are-abdominal-spasms.htm Abdominal spasm AE is a muscle spasm AE that is typically a feeling of cramping in the abdomen caused by a rigid expansion of muscles. It can vary from mild discomfort to moderate or severe pain. JX, LW, YH 腹部痉挛 coronary contraction AE 冠状动脉收缩 Coronary contraction AE is a coronary artery disorder AE that shows coronary contraction. JX, LW, YH lower extremity edema caused by blood vessels AE 因血管扩张引起的下肢水肿 JX, LW, YH Lower extremity edema caused by blood vessels AE is an edema AE that shows excess fluid accumalated in the leg dut to blood vessels. asthenia of lower limbs AE JX, LW, YH Asthenia of lower limbs AE is a asthenia AE that occurs in the lower limbs. It is a condition typified by a weakness of voluntary movement. 下肢无力 small bronchial lumen occlusion AE JX, LW, YH Small bronchial lumen occlusion AE is a lung disorder AE that shows small bronchial lumen occlusion. 小支气管腔闭塞 prolonged orthostatic hypotension AE Prolonged orthostatic hypotension AE is a orthostatic hypotension AE that shows prolonged orthostatic hypotension. 延长体位性低血压时间 JX, LW, YH cross allergic reaction AE JX, LW, YH an allergy AE that shows produce cross or incomplete cross allergic reaction to similar medicinal chemistry structure. 交叉过敏反应 deep venous thrombophlebitis AE Deep venous thrombophlebitis AE is a thrombophlebitis AE that is causes by a blood clot blocking in the deep vein. 深静脉血栓静脉炎 JX, LW, YH change of hematology AE 血液学改变 JX, LW, YH Change of hematology AE is a hematology investigation result abnormal AE that shows the change of hematology. cardiac depression AE Cardiac depression AE is a cardiac disorder AE that shows cardiac depression. 抑制心脏 JX, LW, YH side limb numbness AE JX, LW, YH 侧肢的麻木感 Side limb numbness AE is a numbness AE that shows reduced or loss of sensation on the skin of an arm and leg on the same side of the body. numbness of tongue AE Numbness of tongue AE is a numbness AE that shows abnormal feeling or loss of sensation in the tongue. JX, LW, YH 舌部麻木 numbness of the limbs AE JX, LW, YH Numbness of the limbs AE is a numbness AE that shows reduced or loss of sensation on the skin of the arm and leg. 肢体麻木 lip numbness AE JX, LW, YH 嘴唇发麻 Lip numbness AE is a numbness AE that shows abnormal feeling in the lips, including numbness and tingling. reflex Increased pulse rate AE 反射性脉率增加 Reflex Increased pulse rate AE is a cardiovascular AE that shows increased pulse rate. JX, LW, YH irritation of the digestive tract AE JX, LW, YH 消化道刺激 Irritation of the digestive tract AE is a digestive system AE that shows irritation of the digestive tract. unconscious chorea AE 不自觉舞蹈症 JX, LW, YH Unconscious chorea AE is a chorea AE that is characterized by brief, non-repetitive irregular muscle contractions. phlebectasia of limbs AE Phlebectasia of limbs AE is a vasodilatation AE that shows dilation of the veins in the extremity. 肢端静脉扩张 JX, LW, YH heart beat skip AE 漏跳 Heart beat skip AE is a irregular heartbeat AE which is sometimes called as either heart palpitation, or premature atrial or ventricular contraction are very common occurrences. They may or may not be accompanied by heart conditions or heart problems. WEB: http://ehealthwall.com/heart-skips-a-beat-causes-symptoms-treatment/ JX, LW, YH fatal liver cell necrosis AE JX, LW, YH 致命性肝细胞坏死 Fatal liver cell necrosis AE is a hepatic necrosis AE that has an outcome of fatal liver cell necrosis. warm and hot feeling in the neck AE Warm and hot feeling in the neck AE is a skini warm AE that shows warm and hot feeling in the neck. JX, LW, YH 颈感觉温热 facial warm feeling AE JX, LW, YH 面部感觉温热 Facial warm feeling AE is a skin warm AE that shows a warm feeling in the face. increased peripheral vascular resistance AE 外周血管阻力升高 Increased peripheral vascular resistance AE is a vascular disorder AE that shows increased peripheral vascular resistance, the degree to which the blood vessels impede the flow of blood. High resistance causes an increase in blood pressure, which increases the workload of the heart. JX, LW, YH venous ischemia AE JX, LW, YH Venous ischemia AE is an ischaemia AE that shows in insufficient blood supply in the vein. 静脉供血不足 increased blood creatine AE 血肌酸增加 JX, LW, YH Increased blood creatine AE is a metabolic and nutritional investigation result abnormal AE that shows an increased creatine level in blood. increased nonprotein nitrogen AE 非蛋白氮增加 Increased nonprotein nitrogen AE is an investigation result abnormal AE that shows increased nonprotein nitrogen, the nitrogenous constituents of the blood exclusive of the protein bodies, consisting of the nitrogen of urea, uric acid, creatine, creatinine, amino acids, polypeptides, and an undetermined part known as rest nitrogen. JX, LW, YH soft feces AE Soft feces AE is a abnormal stool AE that shows soft and shapeless of the feces. JX, LW, YH 软便 increased hepatic function AE Increased hepatic function AE is a hepatic function abnormal AE that shows the values of liver function tests (LFTs) high than the normal. JX, LW, YH WEB: http://www.webmd.com/a-to-z-guides/liver-function-test-lft 肝功能升高 knee pain AE 10023477 Knee pain AE is a pain AE that shows discomfort in the structures of both knees. Keen pain may be due to injury, inflammation or infection. 膝痛 WEB: http://www.mayoclinic.org/diseases-conditions/knee-pain/basics/definition/CON-20029534 JX, LW, YH loss of libido AE 10024870 性欲丧失 JX, LW, YH Loss of libido AE is a libido disorder AE that shows loss of the desire for sexual interaction. WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder over sedation AE Over sedation AE is a behavior and neurological AE that shows the over reduction of irritability or agitation. JX, LW, YH 过度镇静 finger tremor AE 手指强硬颤动 JX, LW, YH Finger tremor AE is a tremor AE that shows involuntary muscle contraction and relaxation in the finger. leg cramp AE JX, LW, YH Leg cramp AE is a muscle cramp AE that shows tightening, or spasms, of the muscles in the legs. 腿部痉挛 insomnia AE 10022437 a sleep disorder AE in which there is an inability to fall asleep or to stay asleep as long as desired. SIDER: C0917801 YH, MW HPO: HP_0002360 WEB: https://en.wikipedia.org/wiki/Insomnia CTCAE: E12925 Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease. terminal insomnia AE 10068932 matutinal insomnia AE JX, LW, YH WEB: http://www.wisegeek.com/what-is-terminal-insomnia.htm Terminal insomnia AE is a insomnia AE that is a medical condition affecting sleep patterns. Typically, people who suffer from terminal insomnia wake up after only four to five hours of sleep. For those afflicted, getting back to sleep can be difficult, resulting in fatigue, irritability, and lack of concentration. 早醒 bone marrow granuloma AE 10066816 Bone marrow granuloma AE is a bone marrow disorder AE that shows an organized collection of macrophages in the bone marrow. 骨髓肉芽肿 JX, LW, YH cholestatic liver injury AE 10067969 JX, LW ,YH 胆汁郁积性肝损伤 Cholestatic liver injury AE is a liver damage AE that shows buildup of bile acids in hepatocytes, then causes hepatocellular injury. distant heart sounds AE 心音遥远 JX, LW, YH Distant heart sounds AE is a cardiac disorder AE that shows distant heart sounds. pink skin AE Pink skin AE is a skin AE that shows pink skin. 皮肤粉红 JX, LW, YH acute laryngeal edema AE 10066705 急性喉头水肿 JX, LW, YH Acute laryngeal edema AE is an edema AE that shows acute laryngeal edema, abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions. hypoplastic bone marrow AE 骨髓发育不全 Hypoplastic bone marrow AE is a bone marrow disorder AE that shows insufficient blood stem cells in the marrow. JX, LW, YH bleeding and coagulation disorders AE JX, LW, YH Bleeding and coagulation disorders AE is a hematopoietic system AE that shows bleeding and coagulation disorders. 出凝血功能障碍 polymorphic ventricular tachycardia AE 10036095 多行性室性心动过速 JX, LW, YH WEB: http://www.healthguideinfo.com/arrhythmias-heart-palpitations/p110132/ Polymorphic ventricular tachycardia AE is a ventricular tachycardia AE that is an abnormally fast heart rhythm starting in the ventricles, the lower chambers of the heart. monomorphic ventricular tachycardia AE 10058185 Monomorphic ventricular tachycardia AE is a ventricular tachycardia AE that is a type of tachycardia which has a uniform beat-to-beat QRS morphology. 单行性室性心动过速 JX, LW, YH respiratory tract symptoms AE JX, LW, YH 呼吸道症状 Respiratory tract symptoms AE is a respiratory system AE that is a series of discomforts which occurs in respiratory tract. clammy skin AE Clammy skin AE is a skin AE that occurs when the skin turns cooler than normal and is moist, despite a cooler surface temperature. Clammy skin is often pale. 皮肤湿冷 WEB: http://www.healthgrades.com/symptoms/clammy-skin JX, LW, YH abnormal visual accommodation AE Abnormal visual accommodation AE is an abnormal vision AE that shows abnormal visual accommodation. Accommodation is the process by which the vertebrate eye changes optical power to maintain a clear image or focus on an object as its distance varies. JX, LW, YH 视调节异常 WEB: http://en.wikipedia.org/wiki/Accommodation_%28eye%29 skin allergy AE 皮肤过敏 an allergy AE that shows swelling and irritation of the skin, caused by an allergy to a substance in the environment. JX, LW, YH heaviness of the head AE 10049121 JX, LW, YH 头重感 Heaviness of the head AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the head. rheumatoid factor positive AE 10039080 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003548.htm Rheumatoid factor positive AE is an immunology and allergy investigation result abnormal AE that shows positive of the rheumatoid factor. Rheumatoid factor is a blood test that measures the amount of the RF antibody in the blood. JX, LW, YH 类风湿因子阳性 retinal detachment AE 10038848 CTCAE: E10420 JX, LW, YH 视网膜脱离 NCIt: C26874 WEB: http://www.medicinenet.com/retinal_detachment/article.htm NCIT: C26874 Retinal detachment AE is an eye AE that is a separation of the retina from its attachments to the underlying tissue within the eye. arm pain AE Arm pain AE is a pain AE that shows discomfort in the structures of the arm. It can be caused by a wide variety of problems, ranging from joint injuries to compressed nerves. 手臂疼痛 JX, LW, YH WEB: http://www.mayoclinic.org/symptoms/arm-pain/basics/definition/SYM-20050870 peripheric paresthesia AE JX, LW, YH 外周感觉异常 Peripheric paresthesia AE is a paresthesia AE that shows paresthesia in the peripheric area. edema of glottis AE JX, LW, YH Edema of glottis AE is an edema AE that is a swelling caused by fluid accumulation in the soft tissues of the larynx. The condition, usually inflammatory, may result from an infection, injury, allergy, or inhalation of toxic substances. 声门肿胀 prolonged qrs complex AE QRS时间延长 Prolonged qrs complex AE is a electrocardiogram qrs complex abnormal AE that shows qrs complex prolonged. The QRS complex is a name for the combination of three of the graphical deflections seen on a typical electrocardiogram. JX, LW, YH prolonged bleeding time AE 出血时间延长 JX, LW, YH Prolonged bleeding time AE is a hematology investigation result abnormal AE that shows prolonged time for small blood vessels in the skin close to stop from bleeding. acute generalized exanthematous pustulosis AE 10062372 急性全身性浓疱病 pustular drug eruption AE WEB: http://en.wikipedia.org/wiki/Acute_generalized_exanthematous_pustulosis toxic pustuloderma AE JX, LW, YH Acute generalized exanthematous pustulosis AE is a skin AE that is a not uncommon cutaneous reaction pattern that in 90% of cases is related to medication administration, characterized by a sudden eruption that appears on average five days after the medication is started. upper and lower limbs flare AE Upper and lower limbs flare AE is an edema AE that shows edema in the upper and lower limbs, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues. JX, LW, YH 上下肢红肿 abnormal blood sugar with empty stomach AE Abnormal blood sugar with empty stomach AE is a blood glucose level abnormal AE that shows abnormal blood glucose level with empty stomach. 空腹时血糖异常 JX, LW, YH increased blood sugar with empty stomach AE JX, LW, YH Increased blood sugar with empty stomach AE is blood glucose level decreased AE that shows an increased glucose level in blood with empty stomach. 空腹时血糖升高 hydrochloric acid in gastric juice secretion increased AE Hydrochloric acid in gastric juice secretion increased AE is a gastric disorder AE that shows increased gastric acid. JX, LW, YH 胃酸分泌增多 torsades de pointes AE 10044067 JX, LW, YH WEB: http://en.wikipedia.org/wiki/Torsades_de_pointes 扭转性室速 Torsades de pointes AE is a ventricular tachycardia AE that is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram. proximal myasthenia AE 近端肌无力 Proximal myasthenia AE is a myasthenia AE that shows proximal myasthenia. Myasthenia represents myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatigability. JX, LW, YH dilated skin vessels AE JX, LW, YH Dilated skin vessels AE is a vasodilatation AE that shows vasodilatation in the skin, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. 皮肤血管扩张 numbness of oral mucosa AE Numbness of oral mucosa AE is a numbness AE that shows an abnormal feeling or loss of sensation in the oral mucosa. JX, LW, YH 口腔黏膜发麻 orthostatic dizziness AE 10031125 Orthostatic dizziness AE is a dizziness AE that shows dizziness provocation by sudden postural change. 体位性头晕 JX, LW, YH acid reflux AE 10066872 Acid reflux AE is a digestive system AE that shows the acid and pepsin secreted in the stomach back up in to the esophagus. 反酸 JX, LW, YH jugular phlebectasia AE JX, LW, YH 颈静脉扩张 Jugular phlebectasia AE is a vasodilatation AE that is an isolated saccular or fusiform dilation of a vein without tortuosity. WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708235/ laryngeal edema AE 10023838 laryngeal oedema AE NCIt:C79607 Laryngeal edema AE is an edema AE that shows abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions. JX, LW, YH, MW CTCAE:E13393 喉肿胀 flatus AE 10016769 排气 Flatus AE is a digestive system AE that shows gas or air expelled through the anus. JX, LW, YH continuous polymorphic ventricular tachycardia AE JX, LW, YH 连续性多形性室性心动过速 Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is constantly. intermittent polymorphic ventricular tachycardia AE Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is intermittent. 间歇性多形性室性心动过速 JX, LW, YH aggravated ulcer AE JX, LW, YH Aggravated ulcer AE is a ulcer AE that shows aggravated ulcer. 溃疡加重 heart failure increased AE JX, LW, YH Heart failure increased AE is a cardiovascular disorder AE that shows aggravated heart failure. 心脏衰竭加重 aggravated angina symptoms AE JX, LW, YH 心绞痛症状加剧 Aggravated angina symptoms AE is a angina pectoris AE that shows aggravated angina symptoms. aggravated renal injury AE 肾损害加剧 JX, LW, YH Aggravated renal injury AE is a renal impairment AE that shows aggravated renal injury. aggravated fatigue AE Aggravated fatigue AE is a fatigue AE that shows aggravated fatigue. JX, LW, YH 脱力感加重 persistent nausea AE JX, LW, YH 持续恶心 WEB: http://www.all4naturalhealth.com/persistent-nausea.html Persistent nausea AE is a nausea AE that shows constant nausea. Nausea is considered "persistent" if it continues for more than 2 days, or keeps recurring even after treatment. aggravated Raynaud's syndrome AE JX, LW, YH Aggravated Raynaud's syndrome AE is a Raynaud's syndrome AE that shows aggravated Raynaud's syndrome. Raynaud综合征加重 increased gastric acid secretion with high dose AE Increased gastric acid secretion with high dose AE is a gastric disorder AE that shows increased gastric acid secretion with high dose. JX, LW, YH 高剂量时胃酸分泌增加 persistent vomiting AE 10034716 Persistent vomiting AE is a vomiting AE that occurs frequently throughout the day and is often triggered by even small meals. WEB: http://www.healthhype.com/persistent-and-recurrent-vomiting-emesis-in-adults-and-children.html JX, LW, YH 持续呕吐 hypoacusis AE 10048865 WEB: http://medical-dictionary.thefreedictionary.com/hypoacusis Hypoacusis AE is a hearing disorder AE that shows partial or complete loss of the ability to detect or understand sounds resulting from damage to the outer, middle, or inner ear structures. Causes include exposure to loud noise, ear infections, injuries to the ear, genetic, and congenital disorders. JX, LW, YH 突发听力减退 lip cyanosis AE Lip cyanosis AE is a cyanosis AE that is a condition in which the lips have a bluish discoloration due to a lack of oxygen in the tissues. 嘴唇发紫 WEB: http://www.rightdiagnosis.com/sym/lip_cyanosis.htm JX, LW, YH nail cyanosis AE JX, LW, YH Nail cyanosis AE is a cyanosis AE that shows a dark bluish or purple nail resulting from deficient oxygenation of the blood. 指甲青紫 renal insufficiency AE UMLS ID: C0859242 This term appears to be a synonym to the 'renal failure AE'. JX, LW, YH Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia. 肾功能障碍 hepatic and renal function disorder AE hemolysis AE 10019491 NCIt: C37965 JX, LW, YH 溶血 CTCAE: E10037 Hemolysis AE is a hematopoietic system AE that is the rupturing of erythrocytes (red blood cells) and the release of their contents (cytoplasm) into surrounding fluid. WEB: http://en.wikipedia.org/wiki/Hemolysis lip angioedema AE 唇血管神经性水肿 JX, LW, YH Lip angioedema AE is a angioedema AE that shows lip angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues. tongue angioedema AE JX, LW, YH 舌血管神经性水肿 Tongue angioedema AE is a angioedema AE that shows tongue angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues. acousma AE 幻听 JX, LW, YH Acousma AE is a sensory capability AE that shows a hallucinatory impression of strange sounds. eye burning AE JX, LW, YH Eye burning AE is a eye AE that shows a feeling of burning in the eye. 眼睛灼烧感 worsening renal function AE Worsening renal function AE is a kidney AE that shows worsening renal function. JX, LW, YH 肾功能恶化 mild change of hematology AE Mild change of hematology AE is a change of hematology AE that shows mild change of hematology. JX, LW, YH 轻度的血液学改变 moderate change of hematology AE JX, LW, YH 中度的血液学改变 Moderate change of hematology AE is a change of hematology AE that shows moderate change of hematology. severe lower blood pressure AE Severe lower blood pressure AE is a hypotension AE that shows severe sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. significantly decreased blood pressure AE 严重的血压降低 JX, LW, YH elevated blood transaminase reversibility AE JX, LW, YH Elevated blood transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly. 血氨基转移酶可逆性升高 mild gastrointestinal tract reaction AE 轻度胃肠道反应 JX, LW, YH Mild gastrointestinal tract reaction AE is a gastrointestinal disorder AE that shows a mild gastrointestinal disorder. temporary abdominal distention AE JX, LW, YH Temporary abdominal distention AE is a abdominal distension AE that shows a temporary sensation of elevated abdominal pressure and volume. 暂时性腹胀 transient nausea AE JX, LW, YH 暂时性恶心 Transient nausea AE is a nausea AE that is a gastric discomfort associated with the inclination to vomit. persistent tachycardia AE JX, LW, YH 持续心动过速 Persistent tachycardia AE is a tachycardia AE that is an increased heart rate that exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual). It's a constant process. mild headache AE JX, LW, YH 轻度头痛 Mild headache AE is a headache AE that shows mild headache. transient hypoxemia AE Transient hypoxemia AE is a hypoxia AE that is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases. JX, LW, YH 瞬态低氧血症 transient neuroticism AE Transient neuroticism AE is a neuroticism AE that is a type of personality trait that contrasts adjustment or emotional stability with maladjustment. Experience of anxiety, anger, disgust, sadness, embarrassment, and a variety of other negative emotions. JX, LW, YH 瞬态神经质 constant irritability AE 持续烦躁 Constant irritability AE is a irritability AE that shows in the patient being easily annoyed/irritated constantly. JX, LW, YH abnormal atony AE JX, LW, YH Abnormal atony AE is a asthenia AE that is a medical term denoting symptoms of physical weakness and loss of strength. 异常无力 secondary hypotension AE WEB: http://en.wikipedia.org/wiki/Secondary_hypertension 继发性高血压 Secondary hypotension AE is a hypotension AE that is a type of hypertension which by definition is caused by an identifiable underlying secondary cause. JX, LW, YH transient elevated serum transaminase AE 瞬时血清转氨酶升高 Transient elevated serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase transiently. JX, LW, YH transient elevated blood urea nitrogen AE Transient elevated blood urea nitrogen AE is a blood urea level increased AE that shows a transient increase in amount of urea in blood. JX, LW, YH 瞬时血尿素氮升高 apparent increased blood creatine phosphokinase AE JX, LW, YH Apparent increased blood creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an apparent increased level of creatine phosphokinase or phosphocreatine kinase. 明显的血肌酸磷酸激酶增高 severe rhabdomyolysis AE Severe rhabdomyolysis AE is a rhabdomyolysis AE that shows in severe damaged skeletal muscle tissue breaks down rapidly. 严重的横纹肌溶解症 JX, LW, YH mild gastrointestinal bleeding AE JX, LW, YH Mild gastrointestinal bleeding AE is a gastrointestinal hemorrhage AE that shows mild gastrointestinal hemorrhage. 胃肠道轻微出血 occult gastrointestinal tract bleeding AE 胃肠道隐匿性出血 Occult gastrointestinal tract bleeding AE is a gastrointestinal hemorrhage AE that shows occult gastrointestinal hemorrhage. JX, LW, YH nitrate headache AE JX, LW, YH 硝酸盐性头痛 Nitrate headache AE is a headache AE that that is a special headache induced by nitrate. pantomorphia erythema exudativum AE WEB: http://en.wikipedia.org/wiki/Erythema_multiforme JX, LW, YH Pantomorphia erythema exudativum AE is a skin AE that is a skin condition of unknown cause, possibly mediated by deposition of immune complex (mostly IgM) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. It is an uncommon disorder, with peak incidence in the second and third decades of life. 多形性渗出性红斑 high hypodynamia AE High hypodynamia AE is a fatigue AE that is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. 高度乏力 JX, LW, YH short-time nausea AE JX, LW, YH 短暂的恶心 Short-time nausea AE is a nausea AE that shows a gastric discomfort associated with the inclination to vomit. slightly increased aspartic transaminase AE Slightly increased aspartic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of AST which is an enzyme normally present in body tissues especially of the heart and liver, JX, LW, YH 门冬氨酸氨基转移酶轻度升高 slightly increased alanine aminotransferase AE Slightly increased alanine aminotransferase AE is a alanine aminotransferase level increased AE that shows elevated levels of alanine transaminase slightly. JX, LW, YH 丙氨酸氨基转移酶轻度升高 slightly increased lactic dehydrogenase AE 乳酸脱氢酶轻度升高 JX, LW, YH Slightly increased lactic dehydrogenase AE is a blood lactate dehydrogenase level increased AE that shows a slightly increased amount of LDH which is an enzyme that could indicate tissue damage. slightly increased alkaline phosphatase AE JX, LW, YH Slightly increased alkaline phosphatase AE is a blood alkaline phosphatase increased AE that shows elevated levels of alkaline phosphatase slightly. 碱性磷酸酶轻度升高 slightly increased glutamic-oxalacetic transaminase AE 谷草转氨酶轻度升高 Slightly increased glutamic-oxalacetic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of glutamic-oxalacetic transaminase in the heart and liver. JX, LW, YH slightly increased glutamic pyruvic transaminase AE Slightly increased glutamic pyruvic transaminase AE is a alanine aminotransferase level increased AE that shows eelevated levels of glutamic pyruvic transaminase in the liver. JX, LW, YH 谷丙转氨酶轻度升高 transient ischemic stroke AE 暂时性缺血性中风 Transient ischemic stroke AE is a ischemic stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain. JX, LW, YH evidently increased hepatic lipase AE 肝酶显著增加 JX, LW, YH Evidently increased hepatic lipase AE is a hepatic enzyme increased AE that shows an evidently increase in amount of hepatic enzyme in body, commonly includes ALT and AST. It may indicate inflammation or damage to liver cells. mild decline in blood pressure AE JX, LW, YH 血压轻度下降 Mild decline in blood pressure AE is a hypotension AE that shows mild sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. transient cerebral ischemic attacks AE Transient cerebral ischemic attacks AE is a cerebral ischemia AE that shows the sudden death of brain cells in a localized area due to inadequate blood flow. 短暂脑缺血发作 JX, LW, YH transient hypotension AE JX, LW, YH Transient hypotension AE is a hypotension AE that shows transient sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. 瞬时低血压 obviously decreased blood pressure AE 血压明显下降 JX, LW, YH significantly decreased blood pressure AE Obviously decreased blood pressure AE is a hypotension AE that shows obviously sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. transient dizzy AE Transient dizzy AE is a dizziness AE that shows transient dizziness. JX, LW, YH 瞬时头晕 short-time hepatic function disorder AE Short-time hepatic function disorder AE is a hepatic function abnormal AE that shows a short-time abnormal functionality of the liver. 短暂肝功能异常 JX, LW, YH a slightly elevated plasma creatinine level AE 血浆肌酐水平的轻微升高 JX, LW, YH A slightly elevated plasma creatinine level AE is a blood creatinine level increased AE that shows an slightly increased level of creatinine in the blood (due to lack of kidney activity). sudden fall of blood pressure AE 血压突然降低 JX, LW, YH Sudden fall of blood pressure AE is a hypotension AE that shows sudden sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. severe hypertension AE Severe hypertension AE is a hypotension AE that shows severe sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. 严重高血压 JX, LW, YH severe arrhythmia AE 严重心律失常 JX, LW, YH Severe arrhythmia AE is an arrhythmia AE that shows severe abnormal heart rhythm. clinically significant rise of serum transaminase AE 血清转氨酶有临床显著升高 Clinically significant rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly. JX, LW, YH instantaneous sand-blind AE 瞬时视觉模糊 JX, LW, YH Instantaneous sand-blind AE is a vision blurred AE that shows in instantaneous unclear vision. moderately increased urinary nitrogen AE Moderately increased urinary nitrogen AE is a blood urea level increased AE that shows a moderately increase in amount of urea in blood. JX, LW, YH 尿素中度升高 slightly increased urinary nitrogen AE 尿素水平轻微升高 JX, LW, YH Slightly increased urinary nitrogen AE is a blood urea level increased AE that shows a slightly increase in amount of urea in blood. moderately elevated serum creatinine AE Moderately elevated serum creatinine AE is a blood creatinine level increased AE that shows an moderately increased level of creatinine in the blood (due to lack of kidney activity). JX, LW, YH 血肌酐中度升高 slightly increased aminotransferase AE 轻度氨基转氨酶升高 JX, LW, YH Slightly increased aminotransferase AE is a transaminase level increased AE that shows slightly elevated levels of alanine transaminase and aspartate transaminase. severe dizziness AE Severe dizziness AE is a dizziness AE that shows severe dizziness. 严重眩晕 JX, LW, YH mild abdominal discomfort AE JX, LW, YH 轻微腹部不适 Mild abdominal discomfort AE is a abdominal discomfort AE that shows a mild stomach ache. serum potassium concentration of moderately reduced 血清钾浓度的轻度降低 JX, LW, YH, MW A blood potassium decreased quality where the amount of potassium in the blood is moderately decreased. rebound Increased blood pressure AE 反跳性血压升高 JX, LW, YH Rebound Increased blood pressure AE is a hypertension AE that shows rebound sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. excessive lowering of blood pressure AE Excessive lowering of blood pressure AE is a hypotension AE that shows excessive sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. JX, LW, YH 血压过度降低 short-time increased blood sugar AE Short-time increased blood sugar AE is a blood glucose level increased AE that shows a short-time increased glucose level in blood. 短暂血糖升高 JX, LW, YH mild nausea AE JX, LW, YH 轻度恶心 Mild nausea AE is a nausea AE that shows mild nausea. significant and persistent rise of serum transaminase AE Significant and persistent rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently. 血清氨基转移酶显著和持续性升高 JX, LW, YH elevated serum transaminase reversibility AE JX, LW, YH Elevated serum transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly. 血清氨基转移酶可逆性升高 reversible increased creatine phosphokinase AE JX, LW, YH Reversible increased creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an reversible increased level of creatine phosphokinase or phosphocreatine kinase. 肌酸磷酸激酶可逆性升高 persistent and significant increase of serum transaminase AE Persistent and significant increase of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently. 血清转氨酶显著和持续性升高 JX, LW, YH severe bradycardia AE 严重心动过缓 JX, LW, YH Severe bradycardia AE is a bradycardia AE that shows in a resting heart rate of under 60 beats per minutes (BPM). apparent hypotensive reaction AE 显著的低血压反应 JX, LW, YH Apparent hypotensive reaction AE is a hypotension AE that shows apparent sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states. severe skin flush AE 显著皮肤潮红 Severe skin flush AE is a hot flush AE that shows severe hot flush. JX, LW, YH transient sinus cardiac arrest AE Transient sinus cardiac arrest AE is a sinus arrest AE that shows an electrocardiographic finding of transient impulse formation failure in the sinus node. JX, LW, YH 瞬时窦性停搏 low-grade gastralgia AE JX, LW, YH 轻度胃痛 Low-grade gastralgia AE is a stomacheache AE that shows a low-grade painful sensation in the stomach. severe headache AE Severe headache AE is a headache AE that shows severe headache. 严重头痛 JX, LW, YH persistent headache AE JX, LW, YH Persistent headache AE is a headache AE that shows persistent headache. 持续头痛 proarrhythmic effect AE 10036766 Proarrhythmic effect AE is an arrhythmia AE that is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias. WEB: http://en.wikipedia.org/wiki/Proarrhythmia arhythmia auxo-action AE JX, LW, YH 致心律失常 acidosis AE 10000486 10005706 CTCAE:E12237 a metabolism, endocrine, and exocrine system AE that has an outcome of acidosis, i.e., too much acid in the body fluids. URL: http://www.nlm.nih.gov/medlineplus/ency/article/001181.htm Blood pH Decreased YH, SJ, MW NCIt:C28228 increased tendency of biliary calculus AE 胆石增加的趋势 JX, LW, YH Increased tendency of biliary calculus AE is a liver, biliary, and pancreatic AE that shows an increased tendency of biliary calculus. temporarily lose consciousness AE JX, LW, YH 暂时失去知觉 Temporarily lose consciousness AE is a sensory capability AE that shows temporarily lose consciousness. increase breast cancer occurrence AE Increase breast cancer occurrence AE is a breast cancer AE that shows increase breast cancer occurrence. 乳腺癌发生增加 JX, LW, YH anticholinergic effect AE 经讯号传导阻断效应 JX, LW, YH WEB: http://ibs.about.com/od/glossary/g/Anticholeffect.htm Anticholinergic effect AE is a conduction system disorder AE that is physical symptoms resulting from agents that counter the action of acetylcholine, a neurotransmitter (chemical within the nervous system) that is involved in many major bodily functions. These anticholinergic effects typically include constipation, dry mouth, blurred vision, dizziness, and slowing of urination. acquired diaphragmatic eventration AE 10000486 a musculoskeletal system AE that has an outcome of diaphragmatic muscle replaced by fibroelestic tissue. The diaphragm retains its continuity and attachments to the costal margin. However, the weakened hemidiaphragm is displaced into the thorax, which can compromise breathing. URL: http://www.uptodate.com/contents/eventration-of-the-diaphragm-in-infants SJ, YH neutrophilopenia AE 中性白细胞减少 Neutrophilopenia AE is a neutrophil count decreased AE that shows the number of neutrophil is decreased. JX, LW, YH abnormal leucocyte neutrophil AE JX, LW, YH Abnormal leucocyte neutrophil AE is a neutrophil percentage abnormal AE that shows abnormal leucocyte neutrophil. 嗜中性白细胞异常 abnormal eosinocyte AE 嗜酸性粒细胞异常 Abnormal eosinocyte AE is an eosinophil count abnormal AE that shows abnormal eosinocyte. JX, LW, YH eosinopenia AE 10014940 JX, LW, YH 嗜酸细胞减少症 WEB: http://en.wikipedia.org/wiki/Eosinopenia Eosinopenia AE is an eosinophil count abnormal AE that is a form of agranulocytosis where the number of eosinophil granulocytes is lower than expected. aggravated peptic ulcer AE Aggravated peptic ulcer AE is a duodenal ulcer AE that shows aggravated peptic ulcer. 消化性溃疡加重 JX, LW, YH local tissue necrosis AE JX, LW, YH 局部组织坏死 Local tissue necrosis AE is a necrosis AE that shows local tissue necrosis. acute myocardial infarction AE 10000891 SJ, YH a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by diminished blood supply to the heart URL: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/acute-myocardial-infarction/ acute adrenal crisis AE 10001389 an endocrine system AE that results in a life threatening condition due to a lack of cortisol produced by the adrenal glands URL: http://www.nlm.nih.gov/medlineplus/ency/article/000357.htm SJ, YH allodynia AE 10053552 URL http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2814%2970102-4/abstract a pain AE that results in pain from a stimulus that does not usually provoke pain YH, SJ amniotic fluid embolism AE 10001977 an embolism AE in which amniotic fluid, fetal cells, hair or other debris enter the maternal circulation resulting in cardiorespiratory collapse SJ, YH WEB: http://emedicine.medscape.com/article/253068-overview Anaphylactoid Syndrome of Pregnancy diabetic amyotrophy AE 10002027 a muscular weakness AE that has an outcome of weakness followed by wasting of muscles, and excruciating pain in the muscles of the thigh, hip, and buttocks proximal diabetic neuropathy diabetic lumbosacral radiculoplexus neuropathy YH, SJ diabetic polyradiculoneuropathy anesthetic complication AE 10060938 SJ, YH WEB: https://www.dha.gov.ae/EN/Facilities/Hospitals/RashidHospital/SpecializedMedicalService/ClinicalServices/Anesthesiologyandinterventionalpain/pages/sideeffects.aspx an adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment anal fistula AE 10002156 CTCAE: E10464 an anus AE that results in the development of a small channel between the end of the bowel and the skin near the anus WEB: http://www.webmd.boots.com/digestive-disorders/anal-fistula NCIt: C60785 SJ, YH postoperative anemia AE 10054312 SJ, YH postoperative anemia AE is an anemia AE that occurs when a patient with acute bleeding loses enough blood to become anemic bleeding and acute blood loss anemia WEB: http://www.acphospitalist.org/archives/2012/02/coding.htm anger AE 10002368 SJ, YH WEB: http://apa.org/topics/anger/index.aspx a behavior and neurological AE that results in antagonism toward someone or something you feel has deliberately done you wrong: excessive anger can cause problems including increased blood pressure and other physical changes that make it difficult to think straight and can harm your physical and mental health. adhesion AE 10059837 SJ, YH URL: http://en.wikipedia.org/wiki/Adhesion_%28medicine%29 a musculoskeletal system AE that results in the formation of fibrous band between tissues and organs, often as a result of injury during surgery pseudobulbar affect AE 10054196 YH, SJ emotional incontinence labile affect a crying abnormal AE that refers to a neurologic disorder characterized by involuntary crying or uncontrollable episodes of crying and/or laughing, or other emotional displays emotional lability WEB: http://en.wikipedia.org/wiki/Pseudobulbar_affect angiopathy AE 10059245 macroangiopathy SJ, YH cardiovascular AE that results in disease of the arteries, veins, and capillaries microangiopathy WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853 microangiopathy AE 10062198 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853 a cardiovascular AE that results in the walls of small blood vessels becoming so thick and weak that they bleed, leak protein, and slow the flow of blood SJ, YH macroangiopathy AE 10054805 SJ, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853 cerebrovascular disease peripheral vascular disease a cardiovascualr AE that results in the build up of fat and blood clots in the large blood vessels, stick to the vessel walls, and block the flow of blood coronary artery disease ankyloglossia AE 10049244 SJ, YH a muscle AE that results in a congenital anomaly in which a short, lingual frenulum or a highly-attached genioglossus muscle restricts tongue movement tongue-tie WEB: http://www.uptodate.com/contents/ankyloglossia-tongue-tie-in-infants-and-children anorectal disorder AE 10002644 WEB: http://medical-dictionary.thefreedictionary.com/Anorectal+Disorders a digestive system AE that results in a group of medical disorders that occur at the junction of the anal canal and the rectum SJ, YH antepartum hemorrhage AE 10055228 YH, SJ WEB: https://www.rcog.org.uk/globalassets/documents/guidelines/gtg63_05122011aph.pdf a hemorrhage AE that has an outcome of bleeding from or in to the genital tract, occurring from 24 weeks of pregnancy and prior to the birth of the baby. apallic syndrome AE 10002941 SJ, YH Brain damage AE that results in a persistent vegetative state WEB: http://www.rightdiagnosis.com/a/apallic_syndrome/intro.htm APGAR score low AE 10002944 10062552 APGAR is a quick test performed on a neonate at 1 and 5 minutes after birth. The 1-minute score determines how well the baby tolerated the birthing process. The 5-minute score tells the doctor how well the baby is doing outside the mother's womb. Any score lower than 7 is a sign that the baby needs medical attention. The lower the score, the more help the baby needs to adjusting outside the mother's womb YH, SJ WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003402.htm aphasia AE 10002948 a brain disorder AE that causes a person to lose the ability to communicate. Aphasia can affect the ability to express and understand language, both verbal and written. Aphasia typically occurs suddenly after a stroke or a head injury, but it can also come on gradually from a slowly growing brain tumor or a degenerative disease WEB: http://www.mayoclinic.org/diseases-conditions/aphasia/basics/definition/con-20027061 SJ, YH arachnoid cyst AE 10049005 SJ, YH WEB:http://en.wikipedia.org/wiki/Arachnoid_cyst a tumor AE that results in pouches of cerebrospinal fluid covered by arachnoidal cells and collagen that may develop between the surface of the brain and the cranial base or on the arachnoid membrane arachnoiditis AE 10003074 CTCAE:E12591 SJ, YH, MW NCIt:C37913 WEB: http://en.wikipedia.org/wiki/Arachnoiditis a brain disorder AE that causes inflammation of the arachnoid, one of the membranes known as meninges that surround and protect the nerves of the central nervous system, including the brain and spinal cord. arrested labor AE 10003118 SJ, YH A pregnancy AE that results in an interruption in the labor process that is associated with uterine contractions. WEB: http://medical-dictionary.thefreedictionary.com/arrested+labor supraventricular arrhythmia AE 10003130 atrial arrhythmia an arrhythmia AE that is characterized by shortness of breath, heart palpitations, chest tightness, and a very fast pulse. Supraventricular arrhythmias begin in the areas above the heart’s lower chambers, such as the upper chambers (the atria) or the atrial conduction pathways. WEB: http://www.texasheart.org/HIC/Topics/cond/arrhycat.cfm SJ, YH coronary arteriospasm AE 10003225 a cardiac disorder AE which causes a spasm of the large- or medium-sized coronary arteries coronary artery spasm coronary artery vasospasm SJ, YH coronary vasospasm WEB: http://sideeffects.embl.de/se/C0010073/pt arthrofibrosis AE 10058029 joint range of motion decreased AE caused by an excessive amount of scar tissue forming within the joint and surrounding soft tissue spaces SJ, YH WEB: http://en.wikipedia.org/wiki/Arthrofibrosis arteriosclerosis AE 10003210 arteriosclerosis AE is a cardiovascular AE that results in blood vessels and arteries becoming thick and stiff which can restrict blood flow to organs and tissues. SJ, YH WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972 atherosclerosis AE 10003601 WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972 SJ, YH atheroslcerosis AE is a specific arteriosclerosis AE that refers to the buildup of fats, cholesterol and other substances in and on artery walls which can restrict blood flow. atrial tachycardia AE 10003668 10034040 CTCAE: E10166 paroxysmal atrial tachycardia paroxysmal supraventricular tachycardia WEB: http://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/Tachycardia-Fast-Heart-Rate_UCM_302018_Article.jsp# SJ, YH supraventricular tachycardia atrial tachycardia AE is a tachycardia AE that results in a fast heart rate beginning in the upper chambers of the heart NCIt: C34900 blood cortisol increased AE 10005458 blood cortisol decreased AE may indicate that the patient has cushing disease, ectopic cushing syndrome, or a tumor of the adrenal gland that is producing too much cortisol. SJ, YH a hematology investigation result abnormal AE that results in high blood cortisol levels URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm idiopathic thrombocytopenic purpura AE 10050245 WEB: http://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/basics/definition/con-20034239 a cardiovascular disorder AE that results in easy or excessive bruising and bleeding. The bleeding results from unusually low levels of platelets. immune thrombocytopenic purpura SJ, YH bladder pain AE 10005063 a pain AE that is observed in the bladder, usually a symptom of bladder infection. WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2477 YH, SJ blepharospasm AE 10005159 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2481 an eye AE that results in involuntary, forcible closure of the eyelids.The spasms may leave the eyelids completely closed, causing functional blindness even though the eyes and vision are normal. SJ, YH amaurosis fugax AE 10005186 WEB: http://en.wikipedia.org/wiki/Amaurosis_fugax blindness unilateral SJ, YH an abnormal vision AE which has an outcome of loss of vision in one eye that is not permanent. blood cortisol decreased AE 10005457 blood cortisol decreased AE may indicate that the patient has addison disease, hypopituitarism, suppression of normal pituitary or adrenal function. URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm a hematology investigation result abnormal AE that results in low blood cortisol levels SJ, YH blood creatine increased AE 10005464 a hematology investigation result abnormal AE that results in high blood creatine levels blood creatine increased AE may indicate that the kidneys are not fucntioning properly SJ, YH URL: http://www.mayoclinic.org/tests-procedures/creatinine/basics/definition/prc-20014534 bone graft procedure 10005971 YH, SJ a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly blood immunoglobin E increased AE 10005591 a hematology investigation result abnormal AE that signifies that a patient is allergic to a particular substance SJ, YH WEB: http://kidshealth.org/parent/system/medical/test_ige.html blood testosterone decreased AE 10005814 WEB: http://www.webmd.com/men/testosterone-15738 a hematology investigation result abnormal AE that results in low levels of testosterone which can lead to infertility and a low sex drive SJ, YH macrocytic anemia AE 10002064 WEB: http://en.wikipedia.org/wiki/Macrocytic_anemia A macrocytic anemia AE is an anemia AE that has an outcome of a macrocytic anemia, which is an anemia (defined as blood with an insufficient concentration of hemoglobin) in which the red blood cells (erythrocytes) are larger than their normal volume. KM, YH low bone density AE 10049470 SJ, YH WEB: http://nof.org/articles/9 a bone disorder AE that has an outcome of low bone densityl, but not low enough to be considered osteoporosis bone graft AE SJ, YH WEB: http://en.wikipedia.org/wiki/Bone_grafting a surgical AE that occurs after a bone graftr procedure, which replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly. bone marrow edema AE 10051763 SJ, YH WEB: http://www.wisegeek.com/what-is-bone-marrow-edema.htm bone marrow edema AE is an edema AE that occurs when excess fluids in the bone marrow buildup and cause swelling. This condition is often caused by a protective reaction of the body in response to an injury or inflammation bone scan abnormal AE 10061941 WEB: http://www.mountsinai.org/patient-care/health-library/treatments-and-procedures/bone-scan SJ, YH an investigation result abnormal AE that detects areas of increased or decreased bone activity. These may indicate bone injury or disease. brachial plexus injury AE 10006074 SJ, YH WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/peripheral_nerve_surgery/conditions/brachial_plexus_injury_bpi.html Nervous system AE that covers a variety of conditions that may impair function of the brachial plexus nerve network, most of which are caused by trauma. bradyarrhythmia AE 10049765 WEB: http://medical-dictionary.thefreedictionary.com/bradyarrhythmia a bradycardia AE that results in a disturbance in the heart rhythm in which the heart rate is abnormally slowed. SJ, YH bradycardia fetal AE 10006094 WEB:http://medical-dictionary.thefreedictionary.com/fetal+bradycardia a bradycardia AE that results in a fetal heart rate of less than 120 beats per minute, generally associatedwith hypoxia SJ, YH brain death AE 10049054 SJ, YH WEB: http://en.wikipedia.org/wiki/Brain_death a brain disorder AE that results in the complete and irreversible loss of brain function brain herniation AE 10006126 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001421.htm a brain disorder AE that results in brain tissue, cerebrospinal fluid, and blood vessels being moved or pressed away from their usual position inside the skull. SJ, YH brain injury AE 10067967 SJ, YH a brain injury AE,  injury to the brain caused by an external force, that results in a brain AE Traumatic Brain Injury WEB: http://www.biausa.org/FAQRetrieve.aspx?ID=43913 brain mass AE 10052334 10061019 SJ, YH a brain mass AE is a mass or growth of abnormal cells in your brain or close to your brain Intercranial Neosplasm Brain Neoplasm Brain Tumor WEB: http://www.mayoclinic.org/diseases-conditions/brain-tumor/home/ovc-20117132 brain scan abnormal AE 10061943 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007341.htm an imaging investigation result abnormal AE shows how the brain and its tissues are working. Abnormal results may be due to: Alzheimer’s disease or dementia, brain tumors, epilepsy, and movement disorders. PET scan SJ, YH eyelid disorder AE 10061130 WEB: http://www.healthline.com/health/eyelid-disorders#Overview1 Eyelid disorder AE is a eye AE that is a condition specifically affects the eyelid. It can include drooping, twitching, inflammation, paralysis, and growths. Occasional fluttering of one eyelid is normal. JX, LW hepatic steatosis AE 10019708 JX, LW WEB: http://www.bendomd.com/272-hepatic-steatosis-causes-symptoms-treatment.html Hepatic steatosis AE is a liver disorder AE than popularly called as ‘fatty liver’ is a pathological aspect of liver, whose specific cells (hepatocytes) are filled with lipids (fats). It is a reversible liver disease: ‘is not still very ill, but cries for help’. arthropathy AE 10003285 NCIT: C35760 An arthropathy AE is a joint pain AE that has an outcome of arthropahty, which is any disorder of the joints. WEB: http://en.wikipedia.org/wiki/Arthropathy, http://medical-dictionary.thefreedictionary.com/arthropathy KM, YH balanitis AE 10004073 A balantis AE is a reproductive system AE that has an outcome of a balantis, which is an infectious or non-infectious inflammatory process that affects the glans penis. Symptoms include redness and pain of the glans penis and foreskin and discharge. WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000862.htm, http://en.wikipedia.org/wiki/Balanitis KM, YH pruritus genital AE 10037093 genital itching AE JX, LW WEB: http://www.healthgrades.com/symptoms/genital-itching Pruritus genital AE is a pruritus AE that also called genital itching, Itching in the genital region can result from irritation, allergy, inflammation, infection or cancer. Irritation can occur as a result of exposure to chemicals in soaps, feminine hygiene products, perfumes, lubricants, douches, and creams. cholecystitis AE 10008612 CTCAE: E11184 NCIT: C34465 NCIt: C34465 KM, YH cholecystitis AE is an gallbladder enlargement AE that has an outcome of cholecystitis, which is an acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones. WEB: http://en.wikipedia.org/wiki/Cholecystitis, http://www.mayoclinic.org/diseases-conditions/cholecystitis/basics/definition/con-20034277 chromaturia AE 10008796 KM, YH WEB: http://medical-dictionary.thefreedictionary.com/chromaturia Chromaturia AE is an urine abnormality AE that has an outcome of chromaturia, which is an abnormal coloration of the urine. chromosome abnormality AE 10008815 Chromosome abnormality AE is a genetic AE that has an outcome of chromsome abnormality which is a missing, extra, or irregular protion of chromosomal DNA. WEB: http://en.wikipedia.org/wiki/Chromosome_abnormality KM, YH coagulopathy AE 10009802 KM, YH A coagulopathy AE is a blood disorder AE that has an outcome of coagulopathy, which is a condition in which there is a deviation from or interruption of the normal coagulation properties of the blood. WEB: http://en.wikipedia.org/wiki/Coagulopathy combined immunodeficiency AE 10010099 WEB: http://www.ncbi.nlm.nih.gov/books/NBK22254/ KM, YH Combined immunodeficiency AE is an immune system AE that has an outcome of combined immunodeficiency, which represents a group of rare, sometimes fatal, congenital disorders characterized by little or no immune response. hepatic enzyme abnormal AE 10062685 JX, YH Hepatic enzyme abnormal AE is a liver related investigation result abnormal AE that the lab test result of hepatic enzyme deviates from its normal value. coronary artery aneurysm AE 10011071 WEB: http://en.wikipedia.org/wiki/Coronary_artery_aneurysm WEB: http://www.ncbi.nlm.nih.gov/pubmed/9247557 KM, YH A coronary artery aneurysm AE is a coronary artery disorder AE that has an outcome of coronary artery aneurysm, which is a coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times. injection site atrophy AE 10022048 Injection site atrophy AE is an injection-site AE that muscle atrophy occur in the injection site. JX, YH cutaneous tuberculosis AE 10011684 WEB: http://www.dermnetnz.org/bacterial/tuberculosis.html KM, YH A cutaneous tuberculosis AE is a tuberculosis AE that has an outcome of cutaneous tuberculosis, which is an invasion of the skin by Mycobacterium tuberculosis. breath sounds abnormal AE 10064780 WEB: http://www.healthline.com/health/breath-sounds#Overview1 JX, LW Breath sounds abnormal AE is a respiratory system AE that is characterized by abnormal breath sound, it can indicate fluid in the lungs or asthma. skin abrasion AE 10064990 WEB: http://en.wikipedia.org/wiki/Abrasion_%28medical%29 JX, YH Skin abrasion AE is a skin AE that is a wound caused by superficial damage to the skin, no deeper than the epidermis. trigeminal neuralgia AE 10044652 Trigeminal neuralgia AE is a neuralgia AE that is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. The clinical association between TN and hemifacial spasm is the so-called tic douloureux. Fothergill's disease AE WEB: http://en.wikipedia.org/wiki/Trigeminal_neuralgia JX, YH prosopalgia AE face injury AE 10050392 JX, YH Face injury AE is an injury AE that injury occurs in the face. muscle contrature AE 10062575 WEB: http://en.wikipedia.org/wiki/Muscle_contracture Muscle contrature AE is a muscle AE that can occur for many reasons, such as paralysis, muscular atrophy, and forms of muscular dystrophy. Fundamentally, the muscle and its tendons shorten, resulting in reduced flexibility. JX, YH gaze palsy AE 10056696 A palsy AE that has a symmetric limitation of the movements of both eyes in the same direction. WEB: http://one.aao.org/bcscsnippetdetail.aspx?id=f5a77965-de2a-4fb0-82fb-5f4089671ad6 JX, YH conjugate gaze palsy AE Conjugate gaze palsy AE is a gaze palsy AE that is a disorder affecting the ability to move both eyes in the same direction. These palsies can affect gaze in a horizontal, upward, or downward direction. JX, YH WEB: http://en.wikipedia.org/wiki/Conjugate_gaze_palsy horizontal gaze palsy AE WEB: http://en.wikipedia.org/wiki/Horizontal_gaze_palsy Horizontal gaze palsy AE is a gaze palsy AE that is the paresis of conjugate eye movements. JX, YH posture abnormal AE 10036436 JX, YH a behavioral and neurological AE that refers to rigid body movements and chronic abnormal positions of the body. This symptom is not the same as showing poor posture or slumping over. Rather, it is often the result of a serious spinal cord or brain injury. WEB: http://www.healthline.com/symptom/posture-abnormal tonic clonic movements AE 10051171 a behavioral and neurological AE that shows the body becomes entire rigid and uncontrolled jerking. They may last mere seconds, or continue for several minutes. JX, YH eyelid ptosis AE 10015995 JX, LW WEB: http://en.wikipedia.org/wiki/Ptosis_%28eyelid%29 Eyelid ptosis AE is an eye disorder AE that is a drooping or falling of the upper or lower eyelid. facial paresis AE 10051267 facial nerve paralysis AE WEB: http://en.wikipedia.org/wiki/Facial_nerve_paralysis JX, YH Facial paresis AE is a paresis AE that is a common problem that involves the paralysis of any structures innervated by the facial nerve. menstrual disorder AE 10027327 Menstrual disorder AE is an abnormal condition in a woman's menstrual cycle. WEB: http://en.wikipedia.org/wiki/Menstrual_disorder JX, YH fluid retention AE 10016807 JX, YH WEB: http://www.healthgrades.com/symptoms/fluid-retention Fluid retention AE is an abnormal fluid regulation AE that is excess fluid that collects in the tissues in your body. Most commonly, fluid retention is marked by swelling of your feet and lower legs, but swelling could also occur in your arms, hands, face, or other areas of the body. emotional distress AE 10049119 JX, YH WEB: http://en.wikipedia.org/wiki/Emotional_distress Emotional distress AE is a emotional disorder AE that is a Mental distress or anxiety suffered as a response to a sudden, severe, and saddening experience. encephalitis AE 10014581 Encephalitis AE is a nervous system AE that is an acute inflammation of the brain. WEB: http://en.wikipedia.org/wiki/Encephalitis JX, YH cognitive disorder AE 10057668 a psychiatric disorder AE that is a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. JX, YH WEB: http://en.wikipedia.org/wiki/Cognitive_disorder incoherent AE 10021630 Incoherent AE is a speech disorder AE that shows unable to express one's thoughts or ideas in an orderly, intelligible manner. JX, YH WEB: http://medical-dictionary.thefreedictionary.com/incoherent exercise tolerance decreased AE 10051301 WEB: http://copd.about.com/od/glossaryofcopdterms/g/activitytoleran.htm JX, YH Exercise tolerance decreased AE is a systematic AE that shows exercise tolerance decreased. The exercise tolerance refers to the exercise capacity of an individual as measured by their ability to endure exercise and/or the maximum work load achieved during the exercise period. thermal burn AE 10053615 a burn AE that is a type of burn resulted from making contact with heated objects, such as boiling water, steam, hot cooking oil, fire, and hot objects. WEB: http://en.wikipedia.org/wiki/Thermal_burn JX, LW dissociation AE 10013457 a psychiatric disorder AE that describes a wide array of experiences from mild detachment from immediate surroundings to more severe detachment from physical and emotional experience. WEB: http://en.wikipedia.org/wiki/Dissociation_%28psychology%29 JX, YH acupuncture 10000646 Acupuncture is the stimulation of specific acupuncture points along the skin of the body using thin needles. It can be associated with the application of heat, pressure, or laser light to these same points. JX, LW WEB: http://en.wikipedia.org/wiki/Acupuncture mucous membrane disorder AE 10028133 Mucous membrane disorder AE is a systematic AE that the diseases occur in mucous membrane, which is a lining of mostly endodermal origin. JX, YH WEB: http://en.wikipedia.org/wiki/Mucous_membrane demyelinating polyneuropathy AE 10061811 JX, YH a polyneuropathy AE that arises when the myelin sheaths around nerve cells are damaged. Myelin, the insulating layer of tissue that surrounds nerve cells, helps ensure that signals from the brain are rapidly transmitted to the proper places in the body. When myelin is damaged or destroyed, it can lead to problems with communication between the brain and the body. WEB: http://www.healthgrades.com/conditions/chronic-inflammatory-demyelinating-polyneuropathy compartment syndrome AE 10010121 a syndrome AE that results in increased pressure in a muscle compartment which can lead to nerve damage and impaired blood flow. Thick layers of tissue, called fascia, separate groups of muscles in the arms and legs from each other. Inside each layer of fascia is a confined space, called a compartment. The compartment includes the muscle tissue, nerves, and blood vessels. SJ, YH URL: http://www.nlm.nih.gov/medlineplus/ency/article/001224.htm therapeutic response decreased 10043414 Therapeutic response decreased is found among people who take Cialis, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Aspirin, and have Erection problems. JX, LW WEB: http://www.ehealthme.com/ds/cialis/therapeutic+response+decreased bed rest 10050118 Bed rest is a medical treatment in which a person lies in bed for most of some period of time to gain health benefits. JX, LW WEB: http://en.wikipedia.org/wiki/Bed_rest complex partial seizure AE 10010145 WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2 YH, SJ a seizure AE that resutls in impariment of awareness and involuntary but coordinated and repeated movements. autoimmune disorder AE 10061664 NCIt: C2889 JX, YH CTCAE: E11258 WEB: http://en.wikipedia.org/wiki/Autoimmune_disease Autoimmune disorder AE is an immune system AE that arises from an abnormal immune response of the body against substances and tissues normally present in the body (autoimmunity). brainstem hemorrhage AE 10006146 a hemorrhage AE that has an outcome of bleeding into the pons or mesencephalon. SJ, YH brain stem hemorrhage AE is often secondary to brainstem distortion due to rapidly expanding intracranail lessions. WEB: http://medical-dictionary.thefreedictionary.com/brainstem+hemorrhage menstruation irregular AE 10022992 10027339 JX, YH, MW Menstruation irregular AE is a endocrine system AE that is an abnormal variation in length of menstrual cycles in a female. NCIt: C35219 irregular menstruation AE WEB: http://en.wikipedia.org/wiki/Irregular_menstruation CTCAE: E13125 generalised tonic-clonic seizure AE 10018100 WEB: http://en.wikipedia.org/wiki/Tonic%E2%80%93clonic_seizure Generalised tonic-clonic seizure AE is a seizure AE that is a type of generalized seizure that affects the entire brain. Tonic–clonic seizures are the seizure type most commonly associated with epilepsy and seizures in general, though it is a misconception that they are the only type. JX, YH posturing AE 10036437 a psychiatric disorder AE that an involuntary flexion or extension of the arms and legs, indicating severe brain injury. JX, YH WEB: http://en.wikipedia.org/wiki/Abnormal_posturing off label drug use 10053762 JX, LW WEB: http://en.wikipedia.org/wiki/Off-label_use off label use Off label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, unapproved dosage, or unapproved form of administration. demyelination AE 10012305 JX, YH Demyelination AE is a nervous system AE that is any disease of the nervous system in which the myelin sheath of neurons is damaged. WEB: http://en.wikipedia.org/wiki/Demyelinating_disease gram stain negative AE 10018656 WEB: http://en.wikipedia.org/wiki/Gram-negative_bacteria JX, YH Gram stain negative AE is a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-negative bacteria. red blood cells CSF positive AE 10038173 Red blood cells CSF positive AE is a CSF test result abnormal AE that has an outcome of CSF red blood cells count positive. JX, YH CSF white blood cell count increased AE 10053805 CSF white blood cell count increased AE is a CSF test result abnormal AE that has an outcome of CSF white blood cell count increased. JX, YH influenza A virus test positive AE 10070215 Influenza A virus test positive AE is a influenza virus test positive AE that has an outcome of positive result in an influenza A virus test. JX, YH nerve conduction study abnormal AE 10029175 a behavior and neurological test abnormal AE that shows a abnormal result of nerve conduction study (NCS). NCS is a medical diagnostic test commonly used to evaluate the function, especially the ability of electrical conduction, of the motor and sensory nerves of the human body. WEB: http://en.wikipedia.org/wiki/Nerve_conduction_study JX, YH myocardial necrosis AE 10028602 Myocardial necrosis AE is a cardiac disorder AE that shows death of the cells of an area of the heart muscle (myocardium) as a result of oxygen deprivation, which in turn is caused by obstruction of the blood supply. URL: http://medical-dictionary.thefreedictionary.com/myocardial+necrosis JX, YH brainstem infarction AE 10006147 brainstem stroke WEB: http://www.drugs.com/cg/brain-stem-infarction.html SJ, YH WEB: http://en.wikipedia.org/wiki/Brain_stem_stroke_syndrome a brainstem infarction AE is a stroke AE that occurs when blood cannot flow to the brainstem, when oxygen cannot get to an area of the brain, tissue in that area may be damaged. A person may have vertigo, dizziness and severe imbalance without the hallmark of most strokes – weakness on one side of the body. But dizziness alone is not a sign of stroke. Brain stem stroke can also cause diplopia, slurred speech and decreased level of consciousness. breath sounds decreased AE 10006333 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007535.htm SJ, YH a lung disorder AE that occurs when the noises produced by the structures of the lungs during breathing are decreased or absent. Absent or decreased breath sounds can indicate air or fluid around the lungs, increased thickness of chest wall, over-inflation of part of the lungs, or reduced airflow to part of the lungs. Brugada syndrome AE 10059027 SJ, YH a syndrome AE that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. sudden adult death syndrome (SADS) WEB: http://en.wikipedia.org/wiki/Brugada_syndrome buttock pain AE 10048677 CTCAE:E12396 Buttock pain AE is a pain AE that is a common problem in the butt, it can be due to bursitis, bruising, piriformis syndrome, and shingles,or due to more serious diseases with long-term consequences, such as cancer, arthritis of the sacroiliac joints, and herniated disc with sciatica. NCIt:C78228 SJ, YH, MW Butt Pain WEB:http://www.medicinenet.com/buttock_pain/symptoms.htm calcinosis AE 10006938 SJ, YH WEB: http://www.sclero.org/medical/symptoms/skin/calcinosis.html These most commonly occur on the hands, or near joints such as elbows or knees, although they may appear anywhere. Calcinosis may range from one very tiny deposit, to large (and often painful) clusters. a digestive system AE with an outcome of small white calcium lumps forming under the skin that may leak a chalky white fluid. These lumps are formed becuase of too much calcium in the diet. candidiasis AE 10007152 This is a common cause of vaginal infections in women. Also, Candida may cause mouth infections in people with reduced immune function, or in patients taking certain antibiotics. Candida can be found in virtually all normal people but causes problems in only a fraction. WEB: http://medical-dictionary.thefreedictionary.com/candidiasis an infection adverse event that caused by a species of the yeast Candida. SJ, YH cardiac enzymes increased AE 10007548 URL: http://www.webmd.com/heart-disease/cardiac-enzyme-studies cardiac enzymes increased AE may indicate that the heart muscle is injured, such as from a heart attack. SJ, YH a hematology investigation result abnormal AE that occurs when the cardaic enzymes and proteins leak out of damaged heart muscle cells, and their levels in the bloodstream rise. acute decompensated heart failure AE 10007556 10064653 Acute decompensated heart failure AE is a cardiovascular disorder AE that shows a worsening of the symptoms, typically shortness of breath (dyspnea), edema, and fatigue, in a patient with existing heart disease. SJ, YH WEB: http://en.wikipedia.org/wiki/Acute_decompensated_heart_failure Cardiac Failure Acute cardiac massage 10059163 WEB: http://www.thefreedictionary.com/cardiac+massage Cardiac massage is a resuscitative procedure that employs the rhythmic compression of the chest and heart in an effort to restore and maintain the circulation after cardiac arrest or ventricular fibrillation SJ, YH Heart Massage cardiac murmur AE 10007586 WEB: http://www.mayoclinic.org/diseases-conditions/heart-murmurs/basics/definition/con-20028706 SJ, YH Cardiac murmur AE is a cardiac disorder AE that is characterised by abnormal sounds during the heartbeat cycle — such as whooshing or swishing — made by turbulent blood in or near the heart. Heart Murmur catatonia AE 10007776 WEB: http://dictionary.reference.com/browse/catatonia a behavior and neurological AE that is seen most frequently in schizophrenia, characterized by muscular rigidity and mental stupor, sometimes alternating with great excitement and confusion. YH, SJ carotid artery stenosis AE 10007687 a coronary artery disorder AE that results in narrowing of the inner surface of the carotid atery. WEB: http://en.wikipedia.org/wiki/Carotid_artery_stenosis SJ, YH orbital cellulitis AE 10007918 orbital cellulitis AE is a sudden infection of the tissues around the eye, affecting the eyelid, eyebrow, and cheek. SJ, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001012.htm chronic cholecystitis AE 10008617 Chronic cholecystitis AE the inflammation of the gallbladder persisting for a prolonged period of time or having repeated attacks. SJ, YH WEB: http://www.healthline.com/health/chronic-cholecystitis#Overview1 brain lesion AE 10051290 WEB: http://www.webmd.com/brain/brain-lesions-causes-symptoms-treatments SJ, YH a brain lesion AE is an area of injury or disease within the brain. central venous pressure increased AE 10007980 SJ, YH Central venous pressure increased AE is a mesaurement of the pressure of the blood within the superior and inferior vena cava and large veins of the body. Increased pressure can be the result of cardiac failure and congestion of circulation. WEB: http://medical-dictionary.thefreedictionary.com/central+venous+pressure brain disorder AE 10054938 WEB: http://www.healthline.com/health/brain-disorders#Overview1 a brain disorder AE occurs when the brain is damaged by injury, disease, or health conditions. Brain disorders may affect the main areas of your brain that control how you move, think, and behave. Some tumors can constrict the blood vessels in your brain. SJ, YH cerebral infarction AE 10008118 WEB: http://en.wikipedia.org/wiki/Cerebral_infarction SJ a cerebral infarction is a type of ischaemic stroke AE that is caused by a blockage in the blood vessels supplying blood to the brain. cerebrospinal fluid leak AE 10008164 NCIt: C50487 a nervous system AE that occurs when the cerebrospinal fluid leaks through a defect in the dura or the skull and out through the nose or ear resulting from a tear in the dura. CTCAE: E12611 WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/brain_tumor/center/skull-base/types/csf-leak.html cerebrospinal fluid leakage AE SJ, YH, MW cervical dysplasia AE 10008263 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001491.htm a female reproductive system AE that refers to abnormal changes in the cells on the surface of the cervix. The changes are not cancer. But they can lead to cancer of the cervix if not treated. SJ, YH cervical radiculopathy AE 10008303 SJ, YH WEB: http://www.spine-health.com/conditions/neck-pain/what-cervical-radiculopathy a bone disorder AE that results in pain and neurological symptoms resulting from any type of condition that irritates a nerve in the cervical spine. cervical spinal stenosis AE 10008313 WEB: http://www.webmd.com/back-pain/tc/cervical-spinal-stenosis-topic-overview Cervical spinal stenosis AE is a nervous system AE that occurs when the spinal canal in the neck narrows. SJ, YH choking AE 10008589 WEB: http://www.merriam-webster.com/dictionary/choke SJ, YH a respiratory AE that results in the inability to breath because something gets stuck in the throat or because the air is not good for breathing chondrolysis AE 10058112 WEB: http://www.medilexicon.com/medicaldictionary.php?t=17184 a musculoskeletal and connective tissue AE that results in tlhe disappearance of articular cartilage as the result of disintegration or dissolution of the cartilage matrix and cells. SJ, YH chondromalacia AE 10008729 SJ, YH WEB: http://www.healthline.com/health/chondromalacia-patella#Overview1 A joint disorder AE in which the cartilage on the undersurface of the patella deteriorates and softens. therapy adverse event YH, JX an adverse event that occurs after a therapeutic intervention physiotherapy a therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention physical therapy WEB: http://en.wikipedia.org/wiki/Physical_therapy YH, JX simple partial seizure AE 10040703 YH, SJ WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2 a seizure AE that resutls in jerking and muscle rigidity, unusual sensations affecting vision, hearing, smell, taste or touch, and memory or emothional disturbances. chemosis AE 10053163 SJ, YH WEB: http://en.wikipedia.org/wiki/Chemosis conjunctival edema chemosis AE is a conjunctival disorder AE that results in swelling of the conjunctiva die to exudation of abnormaly permeable capillaries. continuous venovenous hemodiafiltration 10066348 YH, SJ a therapeutic intervention that is used in critically ill patients who have experienced multisystem organ failure and in whom acute renal failure has developed. WEB: http://www.medilexicon.com/medicaldictionary.php?t=40071 conversion disorder AE 10010893 YH, SJ a behavior and neurological AE that results in the expression of psychlogical stress in physical ways or a mental or emotional crises that begins to have a physical affect. functional neurological symptom disorder WEB: http://www.mayoclinic.org/diseases-conditions/conversion-disorder/basics/definition/con-20029533 coronary arteriosclerosis AE 10011076 a cardiac disorder AE which causes a thickening and loss of elasticity of the coronary arteries, leading to progressive insufficiency of the arteries. WEB: http://ghr.nlm.nih.gov/glossary=coronaryarteriosclerosis SJ, YH coronary artery atherosclerosis arteriosclerotic coronary artery disease coronary occlusion AE 10011086 WEB: http://en.wikipedia.org/wiki/Coronary_occlusion a cardiac disorder AE which causes a partial or complete blockage of the coronary artery which can lead to heart attack. SJ, YH coronary artery disease AE 10011089 SJ, YH a cardiac disorder AE which results in inflammation and the buildup of plaque which narrow the coronary arteries. WEB: http://www.mayoclinic.org/diseases-conditions/coronary-artery-disease/basics/definition/con-20032038 crepitation AE 10011376 An joint disorder AE that results in the noise produced by the rubbing together of bone or irregular cartilage surfaces. WEB: http://medical-dictionary.thefreedictionary.com/crepitation YH, SJ cryptorchidism AE 10011498 cryptorchidism AE is a male reproductive system AE which results in the absence of one or both testes from the scrotum. WEB: http://en.wikipedia.org/wiki/Cryptorchidism YH, SJ undescended testis decreased CSF glucose AE 10011537 SJ, YH CSF glucose is proportional to blood glucose levels which correspond to 60-70% of the concentration in blood. hypoglycorrhachia decreased CSF glucose AE can be caused by CNS infections, inflammatory conditions, subarachnoid hemorrhage, hypoglycemia, impaired glucose transport, increased CNS glycolytic activity and metastatic carcinoma. wound culture positive AE 10011643 SJ, YH WEB: http://www.webmd.com/a-to-z-guides/skin-and-wound-cultures wound culture positive AE is a a test to find and identify germs that may be growing on the skin or in a wound. If something that can cause infection grows, the culture is positive. The type of organisms may be identified with a microscope, chemical tests, or both. skin cyst AE 10011732 skin cyst AE is a skin AE that occurs when a cluster of cells that have grouped together to form a sac which may contain air, fluids, or semi-solid material. WEB: http://en.wikipedia.org/wiki/Cyst YH, SJ cyst conductive hearing loss AE 10010282 conductive hearing loss AE is a hearing loss AE that results from probelms with the ear canal, ear drum, or middle ear and its little bones. sensorineural hearing loss (SNHL) SJ, YH WEB: http://www.hearingloss.org/content/types-causes-and-treatment transient hearing loss AE 10011900 deafness transitory transient hearing loss AE is a hearing loss AE that results from poor ventilation of the middle ear in children. SJ, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139416/ delusion AE 10012239 SJ, YH WEB: http://www.merriam-webster.com/dictionary/delusion a psychiatric disorder AE that results in a persistent false psychotic belief regarding the self or objects outside the self that is maintained despite indisputable evidence to the contrary. dependent personality disorder AE 10012355 Individuals with Dependent Personality Disorder are often characterized by pessimism and self-doubt, and tend to belittle their abilities and assets. This leads the person to engage in dependent and submissive behaviors that are designed to elicit care-giving behaviors in others. SJ, YH WEB: http://psychcentral.com/disorders/dependent-personality-disorder-symptoms/ a behavioral and neurological AE that results in long-standing need for the person to be taken care of and a fear of being abandoned or separated from important individuals. developmental delay AE 10012559 WEB: http://medical-dictionary.thefreedictionary.com/developmental+delay Nervous system AE that results in failure to meet certain developmental milestones, such as sitting, walking, and talking, at the average age. Developmental delay may indicate a problem in development of the central nervous system. SJ, YH diabetic ketoacidosis AE 10012671 SJ, YH diabetic ketoacidosis AE is a cardiovascular AE that develops when your body is unable to produce enough insulin and begins to break down fat as an alternate fuel, this process produces a buildup of toxic acids in the bloodstream called ketones. WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/basics/definition/con-20026470 dialysis 10061105 Dialysis is the process of removing waste products and excess fluid from the body when the kidneys are not able to adequately filter the blood. WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2980 YH, SJ congenital diaphragmatic hernia AE 10061106 SJ, YH WEB: http://medical-dictionary.thefreedictionary.com/aspiration congenital diaphragmatic hernia AE is a congential disorder in which an absent or partially formed diaphragm results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. This crowding can lead to underdevelopment of the lungs, potentially resulting in life-threatening breathing difficulties that are apparent from birth. diplegia AE 10013033 a paralysis AE that has an outcome of paralysis affecting symmetrical parts of the body. WEB: http://en.wikipedia.org/wiki/Diplegia SJ, YH cystitis interstitial AE 10011796 KM, YH cystitis interstitial AE is a cystitis AE that has an outcome of cystitis interstitial, which is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. WEB: http://www.nlm.nih.gov/medlineplus/interstitialcystitis.html disseminated tuberculosis AE 10013453 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000624.htm KM, YH A disseminated tuberculosis AE is a tuberculosis AE that has an outcome of disseminated tuberculosis, which is a contagious bacterial infection in which TB bacteria has spread from the lungs to other parts of the body through the blood or lymph system. exotosis AE 10015688 KM, YH Exotosis AE is a bone pain AE that has resulted in a non-neoplastic overgrowth of bone. WEB: http://en.wikipedia.org/wiki/Exostosis exudative retinopathy AE 10015901 WEB: http://medical-dictionary.thefreedictionary.com/exudative+retinopathy Coats' disease, Coats' retinitis An exudative retinopathy AE is an eye AE that shows an outcome of exudative retinopathy marked by masses of white or yellowish exudate in the posterior part of the fundus oculi, with deposits of cholesterol and blood debris from retinal hemorrhage, that leads to destruction of the macula and blindness. KM, YH tendinous AE 10016662 WEB: http://en.wikipedia.org/wiki/Tendinosis KM, YH A tendon disorder AE that has an outcome of tendinous which is damage to a tendon at a cellular level. It is thought to be caused by microtears in the connective tissue in and around the tendon, leading to an increase in tendon repair cells. monocytosis AE 10027906 NCIT: C35147 A monocyte percentage abnormal AE that results in abnormally high levels of monocytes in the blood. WEB: http://en.wikipedia.org/wiki/Monocytosis KM, YH genital candidiasis AE 10018143 WEB: http://www.cdc.gov/fungal/diseases/candidiasis/genital/ KM, YH A male reproductive system AE that has an outcome of genital candidiasis, which is a fungal infection due to any types of Candida (types of yeasts). This is a fungal infection of the genital region. WEB: http://en.wikipedia.org/wiki/Candidiasis groin pain AE 10018735 KM, YH A groin pain AE is a pain AE that shows a pain in the groin area. WEB: http://www.webmd.com/pain-management/tc/groin-problems-and-injuries-topic-overview haemolysis AE 10018910 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002372.htm A blood disorder AE that has an outcome of the breakdown of red blood cells. KM, YH hemolysis hepatosplenomegaly AE 10019847 A hepatosplenomegaly AE is a liver inflammation AE that has an outcome of an abnormal enlargement of the liver and spleen. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/imagepages/17215.htm WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3716 hiatus hernia AE 10020028 A gastric disorder AE that occurs when part of your stomach pushes upward through your diaphragm. WEB: http://www.mayoclinic.org/diseases-conditions/hiatal-hernia/basics/definition/con-20030640 KM, YH HIV infection AE 10020161 KM, YH A viral infection AE that is caused by the human immunodeficiency virus. NCIT: C3108 hypertonic bladder AE 10020853 overactive bladder WEB: http://healbladder.info/healbladder/hypertonic-bladder SJ, YH irritable bladder A hypertonic bladder AE is a digestive system AE that where the bladder-storage function that causes a sudden urge to urinate. WEB: http://www.mayoclinic.org/diseases-conditions/overactive-bladder/basics/definition/con-20027632 hypovitaminosis AE 10021135 KM, YH WEB: http://en.wikipedia.org/wiki/Hypovitaminosis A hypovitaminosis AE is a gustatory system AE which shows an insufficiency of one or more essential vitamins. ileitis AE 10021312 WEB: http://en.wikipedia.org/wiki/Ileitis NCIT: C84782 KM, YH A gastrointestinal disorder AE that shows the inflammation of the ileum. joint dislocation AE 10023204 KM, YH A joint pain AE that occurs when there is an abnormal separation in the joint, where two or more bones meet. dislocated joint, luxation WEB: http://en.wikipedia.org/wiki/Joint_dislocation kawasaki disease AE 10023320 NCIT: C34825 WEB: http://en.wikipedia.org/wiki/Kawasaki_disease A syndrome AE that shows Kawasaki's disease, a vasculitis characterized by inflammation of the arteries, particularly the coronary arteries. The vasculitis may lead to aneurysm formation and possibly, heart attacks. It affects young children who usually present with persistent high fever, redness of the mucous membranes of the mouth, redness of the palms and soles, skin rashes, lymphadenitis, and joint pain and swelling. Mucocutaneous Lymph Node Syndrome KM, YH liver abscess AE 10024652 WEB: http://en.wikipedia.org/wiki/Liver_abscess NCIT: C99089 KM, YH An abscess AE where a bacterial, parasitic, or fungal abscess that develops in the liver. It is usually the result of an abdominal infection, trauma, or surgery in the right upper quadrant. Signs and symptoms include abdominal pain, nausea, vomiting, and fever. lividity AE 10024728 KM, YH WEB: http://www.exploreforensics.co.uk/rigor-mortis-and-lividity.html A blood disorder AE that the body's blood supply will stop moving after the heart has stopped pumping it around the inside of the deceased. lymphangitis AE 10025226 A lymphangitis AE is an inflammation AE that has an infection of the lymph vessels (channels). WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007296.htm KM, YH malaria AE 10025487 KM, YH An infection adverse event that results in malaria, a protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia. NCIT: C34797 WEB: http://en.wikipedia.org/wiki/Malaria metabolic acidosis AE 10027417 A metabolic disoder AE where there is increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock. NCIT: C28228 KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000335.htm Acidosis mucous stool AE 10028140 KM, YH An abnormal stool AE that has an outcome of a significant amount of mucus in the stool. The mucus is accompanied by diarrhea, pain or blood may signify an intestinal condition such as infection or inflammation. Increased amounts of mucus in the stool can also occur with cancers of the colon or rectum or with bowel obstruction. WEB: http://www.healthgrades.com/symptoms/mucus-in-stool muscle spasticity AE 10028335 10041416 WEB: http://www.webmd.com/pain-management/pain-management-spasticity KM, YH, MW, MW NCIt: C79750 CTCAE: E12820 spasticity AE A muscle spasm AE that has an outcome of tight or stiff muscles and an inability to control those muscles. neonatal respiratory distress AE 10001052 NCIT: C27560 KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001563.htm Newborn Respiratory Distress Syndrome A respiratory distress AE that has an outcome of a newborn dyspnea (i.e., impaired breathing) with cyanosis, most frequently occurring in premature infants, children of diabetic mothers and infants delivered by cesarean section, and sometimes with no predisposing cause. neutrophilia AE 10029379 A neutrophil count increased AE that has an outcome of an abnormally high level of neutrophils in the blood. WEB: http://en.wikipedia.org/wiki/Neutrophilia KM, YH NCIT: C35164 orchitis AE 10031064 NCIT: C97145 A male reproductive system AE that results in an inflammation of one or both testes due to viral or bacterial infections. Signs and symptoms include enlargement or tenderness of the affected testis, inguinal lymphadenopathy, blood in the semen, and pain during urination, intercourse, or ejaculation. WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001280.htm KM, YH osteitis AE 10031149 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001252.htm Osteitis fibrosa an inflammation AE that occurs in a bone. KM, YH osteolysis AE 10031248 A bone disorder AE that has an dissolution of bone, especially the removal or loss of the calcium of bone. KM, YH NCIT: C50681 WEB: http://en.wikipedia.org/wiki/Osteolysis palpitations AE 10033557 KM, YH WEB: http://en.wikipedia.org/wiki/Palpitations An arrhythmia AE that has an outcome of palpitations, an abnormality of heartbeat characterized by simultaneous awareness of one’s pulse and discomfort. CTCAE: E10163 NCIt: C37999 papule AE 10033733 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003233.htm KM, YH A skin AE that shows a solid, raised spot on the skin that is up to 0.5 centimeter wide, which is a type of skin lesion. parotitis AE 10034038 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001041.htm KM, YH WEB: http://emedicine.medscape.com/article/882461-overview A parotid gladn enlargement AE that has an outcome of parotitis, the inflammation of one or more of the parotid glands. penis disorder AE 10034336 KM, YH A male reproductive system AE that has an disorder in a penis, including priapism, Peyronie's disease, balanitis, phimosis, paraphimosis, and penile cancer. WEB: http://www.medicinenet.com/penis_disorders/article.htm peritonitis AE 10034674 KM, YH An abdominal AE that shows an inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs. WEB: http://en.wikipedia.org/wiki/Peritonitis NCIT: C26849 plasmapheresis AE 10035486 A medical intervention that collects plasma from the peripheral blood while returning the rest to the donor. WEB: http://en.wikipedia.org/wiki/Plasmapheresis plasma exchange KM, YH NCIT: C15304 therapeutic plasma exchange polyarthritis AE 10036030 WEB: http://en.wikipedia.org/wiki/Polyarthritis KM, YH An arthritis AE that has an outcome of polyarthritis, which includes any type of arthritis that involves 5 or more joints simultaneously. prostatic disorder AE 10036956 A male reproductive system AE that affects prostatic gland in the male reproductive system. WEB: http://www.britannica.com/EBchecked/topic/479519/prostatic-disorder KM, YH pseudo lymphoma AE 10037108 A tumor AE that shows a benign disorder of lymphoid cells or histiocytes that produces clinical features of a malignant lymphoma. KM, YH WEB: http://medical-dictionary.thefreedictionary.com/pseudolymphoma pyoderma AE 10037632 A skin AE that shows a pyogenic skin disease. These include superficial bacterial infections such as impetigo, impetigo contagiosa, ecthyma, folliculitis, Bockhart's impetigo, furuncle, carbuncle, tropical ulcer, etc. WEB: http://en.wikipedia.org/wiki/Pyoderma KM, YH pyuria AE 10037686 A urine abnormality AE that shows the presence of white blood cells or pus in the urine, usually a sign of urinary tract infection. WEB: http://medical-dictionary.thefreedictionary.com/pyuria WEB: http://en.wikipedia.org/wiki/Pyuria KM, YH hypernatremia AE 10020679 10020680 hypernaetremia CTCAE: E12293 SIDER: C0595878 a blood sodium abnormal AE that is characterized by an abnormally high level of sodium in the blood HPO: HP_0003228 NCIt: C37970 YH, MW WEB: http://emedicine.medscape.com/article/241094-overview morbilliform rash AE 10037870 WEB: http://www.wisegeek.com/what-is-a-morbilliform-rash.htm WEB: http://en.wikipedia.org/wiki/Morbilliform KM, YH A rash AE that shows a rash like measles. The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places. measles-like maculopapular rash AE vesicular rash AE 10037898 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=11955 KM, YH A rash AE that shows a raised, blistery rash. reticulocyte count increased AE 10038792 A red blood cell count increased AE that has an increased count of reticulocytes in the blood. Reticulocytes are slightly immature red blood cells. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003637.htm acute psychosis AE 10001022 SJ, YH a behavior and neurological AE that results in impaired or inhibited ego functioning in which the ability to process reality-based information is diminished and disordered. WEB: http://medical-dictionary.thefreedictionary.com/acute+psychosis retinopathy of prematurity AE 10038933 WEB: http://en.wikipedia.org/wiki/Retinopathy_of_prematurity An eye AE that shows an abnormal blood vessel development in the retina of the eye and it occurs in infants that are born too early. KM, YH Terry syndrome WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001618.htm retrolental fibroplasia retrolental fibroplasia (RLF) scar AE 10039580 WEB: http://en.wikipedia.org/wiki/Scar NCIT: C34483 A skin AE that results in a scar, a mark left on the skin. KM, YH scleroderma AE 10039710 A skin AE that has an outcome of a localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. KM, YH NCIT: C26746 WEB: http://en.wikipedia.org/wiki/Scleroderma Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys. scrotal oedema AE 10039755 scrotal swelling A male reproductive system AE that has an outcome of an abnormal enlargement of the scrotum, the sac surrounding the testicles. KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003161.htm scrotal edema skin atrophy AE 10040799 KM, YH, MW NCIt:C35163 CTCAE:E13714 atrophy of the skin WEB: http://www.wisegeek.com/what-is-skin-atrophy.htm NCIT: C35163 A skin AE that results in the degeneration and thinning of the epidermis and dermis. skin depigmentation AE 10040825 WEB: http://en.wikipedia.org/wiki/Depigmentation KM, YH A skin discoloration AE that shows the lightening of the skin, or loss of pigment. 皮肤脱色 Depigmentation skin hypopigmentation AE 10040868 CTCAE:E13721 NCIt:C78610 http://en.wikipedia.org/wiki/Hypopigmentation Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation. A skin discoloration AE that shows abnormal lightening of skin due to decreased melanin production or deposition. KM, YH, MW WEB: http://en.wikipedia.org/wiki/Hypopigmentation Hypopigmentation, Pigment Dilution spleen disorder AE 10041633 CTCAE: E10056 NCIt: C35823 WEB: http://www.livescience.com/44725-spleen.html splenic diseases An immune system disorder AE that has an disorder in spleen, the largest organ in the lymphatic system. KM, YH WEB: http://en.wikipedia.org/wiki/Splenic_disease akinesia AE 10001541 URL: http://medical-dictionary.thefreedictionary.com/akinesia a muscle AE that shows the absence or loss of control of voluntary muscle movements. SJ, YH epileptic seizure AE a seizure AE that shows a brief episode of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. 癫痫 WEB: http://en.wikipedia.org/wiki/Epileptic_seizure epilepsy JX, YH optic neuropathy AE 10061323 RR, YH WEB: http://www.allaboutvision.com/conditions/optic-neuritis.htm a cranial neuropathy AE which shows an damage or abnormality to the nerves in the eyes. neuroretinitis AE 10060701 an optic neuropathy AE characterized by optic disc swelling, peripapillary and macular hard exudates, and vitreous cells. WEB: http://www.ncbi.nlm.nih.gov/pubmed/6466175 RR, YH anterior ischemic optic neuropathy AE 10068250 WEB: http://emedicine.medscape.com/article/1216891-overview WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/ RR, YH AION an optic neuropathy AE characterized by vision loss, optic disc swelling, flame hemorrhages, and cotton-wool exudates. It occurs when blood flow is interrupted to the front (anterior) part of the optic nerve (also called optic nerve head). non-arteritic anterior ischemic optic neuropathy AE 10068249 WEB: http://emedicine.medscape.com/article/1216891-clinical#a0217 RR, YH a type of anterior ischemic optic neuropathy AE that presents primarily with vision loss, especially upon wakening, and sectorial disc edema. mixed neuropathy AE WEB: http://www.aafp.org/afp/2010/0401/p887.html RR, YH a peripheral neuropathy AE that shows a combination of axonal and demyelinating neuropathy. sensory peripheral polyneuropathy AE WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html RR, YH a peripheral sensory neuropathy AE that shows neuropathy in many sensory nerves at one time peripheral demyelinating polyneuropathy AE RR, YH a peripheral neuropathy AE that results from the loss of the myelin sheath on peripheral nerves roughly evenly distributed on both sides of the body diabetic neuropathy AE 10012680 a neuropathy AE that shows nerve damage and occurs in a patient with diabetes WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/basics/definition/con-20033336 RR, YH neurological deficit AE RR, YH a nervous system AE that is an umbrella term referring to conditions relating to the nervous system, including loss of sensation and paralysis WEB: http://en.wikipedia.org/wiki/Functional_neurological_deficit staphylococcal abscess AE 10041917 KM, YH abscess An abscess AE that is caused by an Staphylococcus aureus infection. http://medical-dictionary.thefreedictionary.com/staphylococcal+abscess strabismus AE 10042159 heterotropia An eye AE that results in an intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes. WEB: http://en.wikipedia.org/wiki/Strabismus KM, YH cross-eyed wall-eyed telangiectasia AE 10043189 NCIT: C28194 http://en.wikipedia.org/wiki/Telangiectasia KM, YH, MW CTCAE:E13740 A vein discoloration AE that has an outcome of local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes. NCIt:C28194 trismus AE 10044684 A muscle spasm AE that results in the lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication. Trismus is a symptom of tetanus. KM, YH, MW WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=40739 NCIt: C78651 CTCAE:E12541 typhoid fever AE 10045275 WEB: http://www.webmd.com/a-to-z-guides/typhoid-fever Typhoid fever is often contracted by consumption of food or drink contaminated with Salmonella typhi. NCIT: C35089 A bacterial infection AE with an outcome of thypoid fever, a bacterial infectious disorder caused by the Salmonella typhi bacteria. KM, YH tyhpoid urethritis AE 10046480 WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000439.htm KM, YH a urinary system AE that results in the inflammation (swelling and irritation) of the urethra. vitiligo AE 10047642 WEB: http://en.wikipedia.org/wiki/Vitiligo 白癫风；白驳风；白斑 KM, YH NCIT: C26915 a skin discoloration AE which shows a chronic skin disease characterized by portions of the skin losing their pigment. burn AE 10006634 NCIt: C34441 an injury AE that displays a type of injury to flesh or skin caused by heat, electricity, chemicals, friction, or radiation. YH WEB: http://en.wikipedia.org/wiki/Burn CTCAE: E11669 sedimentation rate decreased AE 10049188 ESR http://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate red blood cell sedimentation rate decreased AE KM, YH erythrocyte sedimentation rate Westergren ESR decreased AE a hematopoietic system AE which has a decreased erythrocyte sedimentation rate (ESR). EST is the rate at which red blood cells sediment in a period of one hour. skin turgor decreased AE 10049428 KM, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003281.htm a skin AE that has decreased skin turgor which is the skin's ability to change shape and return to normal (elasticity). gastrointestinal stromal tumour AE 10051066 A tumor AE that shows a tumor occuring in the gastrointestinal tract. WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor KM, YH fluctuance AE 10051723 A bacterial infection AE that has the presence of pus in a bacterial infection. KM, YH WEB: http://dermatology.about.com/library/bldeffluctuance.htm acinetobacter infection AE 10051894 A bacterial infection AE which is caused by Acinetobacter. KM, YH WEB: http://www.cdc.gov/HAI/organisms/acinetobacter.html Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. Acinetobacter infections rarely occur outside of healthcare settings. wound AE 10052428 an injury AE that breaks the skin or other body tissues. WEB: http://www.nlm.nih.gov/medlineplus/woundsandinjuries.html KM, YH peritoneal tuberculosis AE 10053583 KM, YH a tuberculosis AE which is an invasion of the peritoneum by Mycobacterium tuberculosis. WEB: http://www.ncbi.nlm.nih.gov/pubmed/21215540 haemangioma AE a tumor AE that shows a benigh tumor of vascular origin usually seen in early childhood. YH WEB: http://radiopaedia.org/articles/haemangioma vascular occlusion AE 10053648 KM, YH a vascular disorder AE that has an outcome of the blockage of a blood vessel, usually with a clot. WEB: http://en.wikipedia.org/wiki/Vascular_occlusion joint tuberculosis AE 10056367 KM, YH a tuberculosis AE that shows an tuberculosis of the joints. WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577591/ ventricular arrhythmia AE 10047281 an arrhythmia AE that shows abnormal heart rhythms that originate in the bottom chambers of the heart called the ventricles. 室性心律失常 WEB: http://my.clevelandclinic.org/services/heart/departments-centers/ventricular-arrhythmia-center NCIt: C26924 CTCAE: E10230 LW, YH Salmonella AE 10058878 KM, YH WEB: http://en.wikipedia.org/wiki/Salmonella A bacterial infection AE that is caused by Salmonella. hypokalaemia AE 10021015 10021018 CTCAE: E12327 NCIt: C37974 hypopotassemia AE a blood potassium abnormal AE that has a lab test outcome of abnormally lower than normal amount of potassium in the blood hypopotassaemia AE hypokalemia AE WEB: http://en.wikipedia.org/wiki/Hypokalemia WEB: http://www.emedicinehealth.com/low_potassium/article_em.htm YH, MW potassium depletion AE 血钾过少 WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia alpha tumour necrosis factor AE 10059981 KM, YH a necrosis AE, tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (adipokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. WEB: http://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha oral neoplasm AE 10061325 WEB: http://www.nlm.nih.gov/medlineplus/oralcancer.html a tumor AE that that is a benign or malignant neoplasm involving the oral cavity and/or the lips. KM, YH NCIT: C8989 pericardial disease AE 10061338 KM, YH WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878263/ a cardiac disorder AE that can present clinically as acute pericarditis, pericardial effusion, cardiac tamponade, and constrictive pericarditis. peritoneal neoplasm AE 10061344 WEB: http://www.webmd.com/cancer/peritoneal-cancer-prognosis-symptoms-treatments Representative examples of benign neoplasms include adenomatoid tumor and disseminated peritoneal leiomyomatosis. Representative examples of malignant neoplasms include primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma. a tumor AE that shows a benign or malignant neoplasm that affects the peritoneal cavity. KM, YH NCIT: C3322 purulence AE an inflammation AE that shows the formation or presence of pus. KM, YH MedDRA: 10061926 WEB: http://medical-dictionary.thefreedictionary.com/purulence mycobacterial infection AE 10062207 WEB: http://www.nlm.nih.gov/medlineplus/mycobacterialinfections.html NCIT: C26831 a bacterial infection AE with bacteria of the genus Mycobacterium. Mycobacterium Infection KM, YH spinal haemangioma AE 10065275 KM, YH a tumor AE that shows the most common benign spinal neoplasm, often located in the thoracic and lumbar spine, with a peak incidence of occurrence in the fourth to sixth decades. WEB: http://radiopaedia.org/articles/vertebral-haemangioma Omenn syndrome AE 10069097 a syndrome AE that reuslts in an autosomal recessive combined immunodeficiency syndrome caused by mutations in the RAG-1 and RAG-2 genes. It is characterized by the presence of alopecia, erythroderma, desquamation, lymphadenopathy, and chronic diarrhea. WEB: http://en.wikipedia.org/wiki/Omenn_syndrome NCIT: C61240 YH: This is also a genetic AE. We will later find a way to link to there. KM, YH immunodeficiency AE WEB: http://en.wikipedia.org/wiki/Immunodeficiency KM, YH a immune system AE that results in a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. hepatitis C AE NCIT: C14312 HCV KM, YH a hepatitis AE that resutls in a hepatitis C viral infection. WEB: http://en.wikipedia.org/wiki/Hepatitis_C_virus blood phosphate abnormal AE 10054823 a blood phosphorus abnormal AE that shows an abnormal blood phosphate level EB blood albumin abnormal AE 10005800 a hematology investigation result abnormal AE that results in an abnormal level of albumin in the blood EB blood carbon dioxide abnormal AE' YH, MW an electrolyte blood lab test abnormal AE that results in an abnormal level of sodium in the blood hypercapnia AE 10020591 WEB: https://en.wikipedia.org/wiki/Hypercapnia hypercarbia AE DJ, SS, YH, MW UMLS CUI: C0020440 hypercapnea AE CO2 retention AE a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally high blood glucose decreased 10005555 UMLS CUI: C0595883 EB, YH, MW A physical quality that has an decreased level of glucose in the blood blood glucose increased 10005557 EB, YH, MW UMLS CUI: C0595877 A physical quality that has an increased level of glucose in the blood acneiform rash AE 10037847 rash acneiform AE WEB: http://en.wikipedia.org/wiki/Acne_vulgaris The term "acneiform", literally, refers to an appearance similar to acne. Acne vulgaris (or simply acne) is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring. acneiform eruption AE CTCAE: E13694 YH, MW NCIt: C35277 WEB: http://en.wikipedia.org/wiki/Acneiform_eruption a rash AE that shows follicular eruptions characterized by papules and pustules resembling acne. papulopustular rash AE 10069138 A rash AE that is characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back. WEB: http://www.medaphile.com/medical-dictionary/papulopustular-rash NCIt: C80119 YH Unlike acne, papulopustular rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions. CTCAE: E11491 cranial neuropathy AE 10061096 an neuropathy AE that occurs when any of the twelve cranial nerves (nerves that exit from the brain directly) are damaged. WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy MW, YH auditory neuropathy AE MW, YH WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy a cranial neuropathy AE which shows an damage or abnormality to the nerve that carries signals from the inner ear to the brain and is responsible for hearing. cognitive disturbance AE 10009845 CTCAE: E12617 MW, YH NCIt: C27101 a cognitive disorder AE that shows conspicuous changes in cognitive functions. focal neuropathy AE an neuropathy AE that is restricted to one nerve or group of nerves, or one area of the body WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy MW, YH thromboembolism AE 10043565 WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=25032 MW, YH CTCAE: E13825 thromboembolic event AE a vascular disorder AE that form in a blood vessel a clot (thrombus) that breaks loose and is carried by the blood stream to plug another vessel. cardiovascular injury AE 10007654 UMLS CUI: C0560570 YH an injury AE that occurs in the cardiovascular system heart injury AE 10061200 a cardiovascular injury AE that occurs in a heart. UMLS CUI: C0018805 YH myocardial rupture AE 10028604 a heart injury AE that shows a laceration or tearing of the myoardium, which is the muscular tissue of the heart. YH WEB: https://en.wikipedia.org/wiki/Myocardial_rupture UMLS CUI: C0018813 hypertensive cardiomyopathy AE 10058222 WEB: http://www.freemd.com/hypertensive-cardiomyopathy/overview.htm a cardiomyopathy AE that is characterized by a weekened heart caused by the effects of high blood pressure. UMLS CUI: C1144799 YH hypertrophic obstructive cardiomyopathy AE 10020204 ASH UMLS CUI: C0007194 IHSS A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy causes an obstruction of the outflow of blood from the left ventricle of the heart idiopathic hypertrophic subaortic stenosis WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive asymmetric septal hypertrophy YH HOCM hypertrophic non-obstructive cardiomyopathy AE apical hypertrophic cardiomyopathy Yamaguchi Syndrome WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy non-obstructive cardiomyopathy idiopathic hypertrophic subaortic stenosis A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy does not cause an obstruction of the outflow of blood from the left ventricle of the heart WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive YH Yamaguchi Hypertrophy cardiac function test abnormal AE 10058479 UMLS CUI: C0438177 a cardiovascular investigation result abnormal AE that results in an abnormal result on a test used to evaluate heart function YH WEB: http://www.drsinatra.com/heart-function-tests-to-assess-heart-disease-risk/ WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures multiple cardiac defects AE 10058479 WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures YH a cardiac disorder AE that results in multiple cardiac defects. UMLS CUI: C0438177 device occlusion AE 10064685 UMLS CUI: C1608397 an injury and procedural complication AE that results in a blockage of a device. YH device AE YH a procedural complication AE that occurs after the usage of a device. Grade 1 skin ulceration AE MW, YH WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx CTCAE: E13731 a skin ulceration AE that has a combined area of ulcers <1 cm and nonblanchable erythema of intact skin with associated warmth or edema Grade 2 skin ulceration AE 1 0 WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx a skin ulceration AE that has a combined area of ulcers 1 - 2 cm and partial thickness skin loss involving skin or subcutaneous fat MW, YH CTCAE: E13732 Grade 3 skin ulceration AE CTCAE: E13733 MW, YH WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx a skin ulceration AE that has a combined area of ulcers >2 cm and full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia Grade 4 skin ulceration AE a skin ulceration AE that has any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx MW, YH CTCAE: E13734 Laryngopharyngeal dysesthesia AE 10062667 NCIt: C78414 MW, YH A dysesthesia AE that shows an uncomfortable persistent sensation in the area of the laryngopharynx. CTCAE: E13433 initial hospitalization AE WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm a hospitalization AE that leads to an intial hospitalization. YH, JX prolonged hospitalization AE a hospitalization AE that leads to a prolonged hospitalization. YH, JX WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm local AE an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation. YH, JX URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction injury or procedural complication AE injury and procedural complication AE an adverse event that shows a result of injury or procedural complication. JX, YH central nervous system AE JX, YH a nervous system AE that occurs in the central nervous system meninges AE WEB: https://en.wikipedia.org/wiki/Meninges JX, YH a nervous system AE that occurs in the area of meninges meninges inflammation AE an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001847 delusions AE 10012260 a mental disorder that has false personal beliefs held contrary to reality, despite contradictory evidence and common sense. NCIt: C26741 CTCAE: E12904 MW, YH laryngeal inflammation AE 10065735 an inflammation AE that has an inflammation involving the larynx. MW, YH NCIt: C26811 CTCAE: E13411 testicular disorder AE 10043306 a male reproductive system AE that has involvement of the testis. CTCAE: E13215 NCIt: C26890 MW, YH urinary frequency AE 10046539 MW, YH NCIt: C26906 CTCAE: E13039 an urinary system AE that has urination at short intervals. vaginal inflammation AE 10046916 a reproduction system inflammation AE that has inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge. NCIt: C26911 MW, YH CTCAE: E13270 trigeminal nerve disorder AE 10060890 MW, YH a cranial neuropathy AE that has involvement of the trigeminal nerve (fifth cranial nerve). CTCAE: E12841 NCIt: C26952 accessory nerve disorder AE 10060929 NCIt: C26953 MW, YH cranial neuropathy AE that has involvement of the accessory nerve (eleventh cranial nerve). CTCAE: E12573 hypoglossal nerve disorder AE 10061212 a cranial neuropathy AE that has involvement of the hypoglossal nerve (twelfth cranial nerve). NCIt: C26954 CTCAE: E12692 MW, YH pharyngeal hemorrhage AE 10055315 MW, YH CTCAE: E13460 NCIt: C26986 a hemorrhage AE that has bleeding from the pharynx. brachial plexopathy AE 10065417 NCIt: C27194 a distal neuropathy AE that has regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand. CTCAE: E12601 MW, YH acoustic nerve disorder NOS AE 10000521 MW, YH a cranial neuropathy AE that has involvement of the acoustic nerve (eighth cranial nerve) NCIt: C27207 CTCAE: E12577 olfactory nerve disorder AE 10056388 a cranial neuropathy AE that has involvement of the olfactory nerve (first cranial nerve). CTCAE: E12755 MW, YH NCIt: C27210 glossopharyngeal nerve disorder AE 10061185 NCIt: C27211 a cranial neuropathy AE that has involvement of the glossopharyngeal nerve (ninth cranial nerve). MW, YH CTCAE: E12672 vagus nerve disorder AE 10061403 NCIt: C27591 MW, YH a cranial neuropathy AE that has involvement of the vagus nerve (tenth cranial nerve). CTCAE: E12845 abducens nerve disorder AE 10053662 MW, YH NCIt: C27593 a cranial neuropathy AE that has involvement of the abducens nerve (sixth cranial nerve). CTCAE: E12569 facial nerve disorder AE 10061457 a cranial neuropathy AE that has involvement of the facial nerve (seventh cranial nerve). NCIt: C27594 MW, YH CTCAE: E12668 oculomotor nerve disorder AE 10053661 CTCAE: E12751 MW, YH a cranial neuropathy AE that has involvement of the oculomotor nerve (third cranial nerve). NCIt: C27598 dysesthesia AE 10062872 CTCAE: E12639 a sensory neuropathy AE that has distortion of sensory perception, resulting in an abnormal and unpleasant sensation. NCIt: C28246 MW, YH dyspareunia AE 10013941 NCIt: C2997 CTCAE: E13081 a pain AE that has painful or difficult coitus. MW, YH exostosis AE 10015688 CTCAE: E12404 MW, YH NCIt: C3029 a bone disorder AE that has non-neoplastic overgrowth of bone. gynecomastia AE 10018801 CTCAE: E13115 NCIt: C3073 MW, YH an endocrine system AE that has excessive development of the breasts in males. hydrocephalus AE 10020508 NCIt: C3111 MW, YH a brain edema AE that has an abnormal increase of cerebrospinal fluid in the ventricles of the brain. CTCAE: E12682 lymphedema AE 10025233 NCIt: C3207 CTCAE: E13802 an edema AE that has excessive fluid collection in tissues that causes swelling. MW, YH menopause AE 10027308 NCIt: C3231 a menstrual disorder AE that has the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age. MW, YH CTCAE: E13750 obesity AE 10029883 CTCAE: E12361 a physical examination result abnormal AE that is having a high amount of body fat. NCIt: C3283 MW, YH adult respiratory distress syndrome AE 10001409 MW, YH a lung inflammation AE that has progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. CTCAE: E13299 NCIt: C3353 Superior vena cava syndrome AE CTCAE: E13819 NCIt: C3396 MW, YH a cardiovascular AE that has obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache. dysmenorrhea AE 10013934 a menstrual disorder AE that has abnormally painful abdominal cramps during menses. MW, YH NCIt: C34559 CTCAE: E13077 euphoria AE 10015533 a behavior and neurological AE that has an exaggerated feeling of well-being which is disproportionate to events and stimuli. CTCAE: E12915 MW, YH NCIt: C34598 flank pain AE 10016750 CTCAE: E12414 a pain AE that has marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. MW, YH NCIt: C34615 glucose intolerance AE 10052426 CTCAE: E12264 a metabolic disorder AE that has an inability to properly metabolize glucose. MW, YH NCIt: C34646 hemoglobinuria AE 10019489 MW, YH CTCAE: E13006 NCIt: C34677 an urine abnormality AE that has laboratory test results that indicate the presence of free hemoglobin in the urine. hypohidrosis AE 10021013 a sweating AE that has reduced sweating. MW, YH NCIt: C34718 CTCAE: E13652 kyphosis AE 10023509 NCIt: C34754 a bone disorder AE that has an abnormal increase in the curvature of the thoracic portion of the spine. CTCAE: E12447 MW, YH lordosis AE 10024842 MW, YH CTCAE: E12451 a bone disorder AE that has an abnormal increase in the curvature of the lumbar portion of the spine. NCIt: C34787 oligospermia AE 10030300 a male reproductive system AE that has a decrease in the number of spermatozoa in the semen. CTCAE: E13141 NCIt: C34860 MW, YH avascular necrosis AE 10066480 MW, YH a necrosis AE that has necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. CTCAE: E12382 NCIt: C34880 bullous dermatitis AE 10006556 CTCAE: E13617 NCIt: C35149 an inflammation AE that has inflammation of the skin characterized by the presence of bullae which are filled with fluid. MW, YH dysphasia AE 10013951 CTCAE: E12646 MW, YH NCIt: C35546 a speech disorder AE that has impairment of verbal communication skills, often resulting from brain damage. vaginal stricture AE 10053496 NCIt: C36064 MW, YH CTCAE: E13290 a female reproductive system AE that has a narrowing of the vaginal canal. alkalosis AE 10001680 CTCAE: E12247 MW, YH a metabolism, endocrine, and exocrine system AE that has abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues. NCIt: C37909 Hiccups AE 10020039 CTCAE: E13380 a gastrointestinal disorder AE that has repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm. MW, YH NCIt: C37966 proteinuria AE 10037032 MW, YH CTCAE: E13008 an urine abnormality AE that has laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin. NCIt: C38012 erythroderma AE 10015277 MW, YH NCIt: C39646 an inflammation AE that has generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area. CTCAE: E13633 pyramidal tract syndrome AE 10063636 CTCAE: E12780 a syndrome AE that has dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination. MW, YH NCIt: C43245 edema cerebral AE 10014217 MW, YH NCIt: C4909 CTCAE: E12650 a brain edema AE that has swelling due to an excessive accumulation of fluid in the brain. treatment related secondary malignancy AE 10049737 a tumor AE that has development of a malignancy most probably as a result of treatment for a previously existing malignancy. CTCAE: E12561 MW, YH NCIt: C4969 intracranial hemorrhage AE 10022763 a hemorrhage AE that has bleeding from the cranium. MW, YH NCIt: C50438 CTCAE: E12696 fetal death AE 10016479 NCIt: C50620 a death AE that has death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. CTCAE: E12855 MW, YH transient ischemic attacks AE 10044391 MW, YH a ischemia AEE that has a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. CTCAE: E12834 NCIt: C50781 vaginal discharge AE 10046901 CTCAE: E13251 NCIt: C50795 afemale reproductive system AE that has vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. MW, YH vasovagal reaction AE 10047166 CTCAE: E12851 MW, YH NCIt: C50798 a sensory capability AE that has a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve. premature delivery AE 10036595 apregnancy AE that has delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation. MW, YH NCIt: C50917 早产 CTCAE: E12867 mania AE 10026749 MW, YH CTCAE: E12936 NCIt: C61374 a psychiatric disorder AE that has excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood. hirsutism AE 10020112 MW, YH NCIt: C61444 a hair growth abnormal AE that has the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen) CTCAE: E13642 osteonecrosis of jaw AE 10064658 NCIt: C63924 CTCAE: E12502 a necrosis AE that has a necrotic process occurring in the bone of the mandible. MW, YH abdominal soft tissue necrosis AE 10065775 MW, YH CTCAE: E12369 a necrosis AE that has a necrotic process occurring in the soft tissues of the abdominal wall. NCIt: C78165 alcohol intolerance AE 10001598 CTCAE: E12242 a metabolic disorder AE that has an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. MW, YH NCIt: C78167 anorgasmia AE 10002652 NCIt: C78177 MW, YH a psychiatric disorder AE that has an inability to achieve orgasm. CTCAE: E12880 bladder perforation AE 10063575 CTCAE: E12979 NCIt: C78208 an urinary system AE that has a rupture in the bladder wall. MW, YH bladder spasm AE 10048994 CTCAE: E12984 MW, YH NCIt: C78210 an urinary system AE that has a sudden and involuntary contraction of the bladder wall. bronchopulmonary hemorrhage AE 10065746 a hemorrhage AE that is bleeding from the bronchial wall and/or lung parenchyma. CTCAE: E13346 MW, YH NCIt: C78224 bronchial obstruction AE 10006440 MW, YH NCIt: C78225 a respiratory system AE that has blockage of a bronchus passage, most often by bronchial secretions and exudates. CTCAE: E13328 bronchial stricture AE 10063524 a respiratory system AE that has a narrowing of the bronchial tube. NCIt: C78226 CTCAE: E13334 MW, YH central nervous system necrosis AE 10065784 a necrosis AE that has a necrotic process occurring in the brain and/or spinal cord. MW, YH CTCAE: E12605 NCIt: C78236 chest wall pain AE 10008496 NCIt: C78238 MW, YH CTCAE: E12400 a pain AE that has marked discomfort sensation in the chest wall region. cystitis noninfective AE 10063057 NCIt: C78250 CTCAE: E12994 MW, YH a cystitis AE that has inflammation of the bladder which is not caused by an infection of the urinary tract. delayed orgasm AE 10057066 MW, YH a psychiatric disorder AE that has sexual dysfunction characterized by a delay in climax. NCIt: C78252 CTCAE: E12895 ejaculation disorder AE 10014326 CTCAE: E13085 NCIt: C78264 MW, YH a male reproductive system AE that has problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation. facial muscle weakness AE 10051272 CTCAE: E12664 MW, YH NCIt: C78290 a muscular weakness AE that has a reduction in the strength of the facial muscles. fallopian tube obstruction AE 10065789 NCIt: C78293 CTCAE: E13092 MW, YH a female reproductive system AE that has blockage of the normal flow of the contents in the fallopian tube. fallopian tube stenosis AE 10065791 a female reproductive system AE that has a narrowing of the fallopian tube lumen. MW, YH NCIt: C78295 CTCAE: E13096 fat atrophy AE 10016241 CTCAE: E13638 a connective tissue disorder AE that has shrinking of adipose tissue. MW, YH NCIt: C78297 female genital tract fistula AE 10061149 NCIt: C78298 CTCAE: E13102 a fistula AE that has an abnormal communication between a female reproductive system organ and another organ or anatomic site. MW, YH feminization acquired AE 10054382 CTCAE: E13108 MW, YH NCIt: C78299 an endocrine system AE that has the development of secondary female sex characteristics in males due to extrinsic factors. fibrosis deep connective tissue AE 10065799 MW, YH CTCAE: E12408 a connective tissue disorder AE that has fibrotic degeneration of the deep connective tissues. NCIt: C78301 generalized muscle weakness AE 10062572 MW, YH CTCAE: E12418 NCIt: C78323 a muscular weakness AE that has a reduction in the strength of muscles in multiple anatomic sites. growth suppression AE 10018761 a musculoskeletal and connective tissue AE that has stature that is smaller than normal as expected for age. NCIt: C78328 CTCAE: E12422 MW, YH head soft tissue necrosis AE 10065779 CTCAE: E12426 MW, YH NCIt: C78331 a necrosis AE that has a necrotic process occurring in the soft tissues of the head. hematosalpinx AE 10060602 a female reproductive system AE that has the presence of blood in a fallopian tube. NCIt: C78332 MW, YH CTCAE: E13119 hypersomnia AE 10020765 a sleep disorder AE that has characterized by excessive sleepiness during the daytime. NCIt: C78346 CTCAE: E12688 MW, YH iron overload AE 10065973 NCIt: C78393 CTCAE: E12350 a homeostasis AE that has accumulation of iron in the tissues. MW, YH ischemia cerebrovascular AE 10023030 an ischemia AE that has a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage. MW, YH NCIt: C78394 CTCAE: E12702 IVth nerve disorder AE 10065836 CTCAE: E12705 a cranial neuropathy AE that has involvement of the trochlear nerve (fourth cranial nerve). MW, YH NCIt: C78395 joint range of motion decreased cervical spine AE 10065796 NCIt: C78404 a joint disorder AE that has a decrease in flexibility of a cervical spine joint. MW, YH CTCAE: E12439 joint range of motion decreased lumbar spine AE 10065800 NCIt: C78405 MW, YH CTCAE: E12443 a joint disorder AE that has a decrease in flexibility of a lumbar spine joint. laryngeal fistula AE 10065786 CTCAE: E13399 a fistula AE that has an abnormal communication between the larynx and another organ or anatomic site. MW, YH NCIt: C78410 laryngeal hemorrhage AE 10065759 MW, YH CTCAE: E13405 NCIt: C78411 a hemorrhage AE that has bleeding from the larynx. laryngeal mucositis AE 10065880 an inflammation AE that has an inflammation involving the mucous membrane of the larynx. NCIt: C78412 CTCAE: E13415 MW, YH laryngeal obstruction AE 10059639 NCIt: C78413 a respiratory system AE that has blockage of the laryngeal airway. MW, YH CTCAE: E13421 libido decreased AE 10024419 CTCAE: E12929 a libido disorder AE that has a decrease in sexual desire. MW, YH NCIt: C78432 libido increased AE 10024421 CTCAE: E12932 a libido disorder AE that has an increase in sexual desire. MW, YH NCIt: C78433 lipohypertrophy AE 10062315 a skin AE that has hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. NCIt: C78436 CTCAE: E13657 MW, YH lymph leakage AE 10065773 CTCAE: E13797 MW, YH an immune system AE that has the loss of lymph fluid into the surrounding tissue or body cavity. NCIt: C78439 lymphocele AE 10048642 CTCAE: E13806 an immune system AE that has a cystic lesion containing lymph. MW, YH NCIt: C78442 mediastinal hemorrhage AE 10056356 CTCAE: E13444 NCIt: C78443 MW, YH a hemorrhage AE that has bleeding from the mediastinum. movements involuntary AE 10028041 MW, YH CTCAE: E12728 a movement disorder AE that has uncontrolled and purposeless movements. NCIt: C78453 muscle weakness left-sided AE 10065780 a muscular weakness AE that has a reduction in the strength of the muscles on the left side of the body. CTCAE: E12455 NCIt: C78455 MW, YH muscle weakness lower limb AE 10065776 MW, YH CTCAE: E12459 NCIt: C78456 a muscular weakness AE that has a reduction in the strength of the lower limb muscles. muscle weakness right-sided AE 10065794 CTCAE: E12463 MW, YH NCIt: C78457 a muscular weakness AE that has a reduction in the strength of the muscles on the right side of the body. muscle weakness trunk AE 10065795 a muscular weakness AE that has a reduction in the strength of the trunk muscles. MW, YH NCIt: C78458 CTCAE: E12467 muscle weakness upper limb AE 10065895 CTCAE: E12471 MW, YH NCIt: C78459 a muscular weakness AE that has a reduction in the strength of the upper limb muscles. musculoskeletal deformity AE 10065783 MW, YH NCIt: C78488 a musculoskeletal and connective tissue AE that has a malformation of the musculoskeletal system. CTCAE: E12481 nail discoloration AE 10028691 NCIt: C78492 CTCAE: E13661 MW, YH a nail AE that has a change in the color of the nail plate. nail loss AE 10049281 NCIt: C78494 MW, YH a nail AE that has loss of all or a portion of the nail. CTCAE: E13663 nail ridging AE 10062283 a nail AE that has vertical or horizontal ridges on the nails. CTCAE: E13666 NCIt: C78499 MW, YH neck soft tissue necrosis AE 10065781 CTCAE: E12497 a necrosis AE that has a necrotic process occurring in the soft tissues of the neck. NCIt: C78502 MW, YH nipple deformity AE 10065823 MW, YH CTCAE: E13138 a female reproductive system AE that has a malformation of the nipple. NCIt: C78503 ovarian hemorrhage AE 10065763 a hemorrhage AE that has bleeding from the ovary. NCIt: C78511 MW, YH CTCAE: E13145 ovarian rupture AE 10033279 MW, YH a female reproductive system AE that is tearing or disruption of the ovarian tissue. NCIt: C78513 CTCAE: E13151 ovulation pain AE 10033314 a pain AE that has marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle. MW, YH CTCAE: E13157 NCIt: C78514 pelvic floor muscle weakness AE 10064026 MW, YH a muscular weakness AE that has a reduction in the strength of the muscles of the pelvic floor. NCIt: C78524 CTCAE: E13161 pelvic soft tissue necrosis AE 10065793 CTCAE: E12516 MW, YH a necrosis AE that has a necrotic process occurring in the soft tissues of the pelvis. NCIt: C78525 penile pain AE 10034310 MW, YH NCIt: C78527 CTCAE: E13171 a pain AE that has marked discomfort sensation in the penis. personality change AE 10034719 NCIt: C78548 CTCAE: E12942 a psychiatric disorder AE that has a conspicuous change in a person's behavior and thinking. MW, YH pharyngeal fistula AE 10034825 NCIt: C78551 MW, YH CTCAE: E13454 a fistula AE that has an abnormal communication between the pharynx and another organ or anatomic site. pharyngeal mucositis AE 10065881 an inflammation AE that has an inflammation involving the mucous membrane of the pharynx. CTCAE: E13466 NCIt: C78553 MW, YH pharyngeal necrosis AE 10065706 CTCAE: E13472 a necrosis AE that has a necrotic process occurring in the pharynx. MW, YH NCIt: C78554 pharyngeal stenosis AE 10050028 NCIt: C78555 MW, YH CTCAE: E13476 a respiratory system AE that has a narrowing of the pharyngeal airway. prostatic hemorrhage AE 10055325 NCIt: C78572 CTCAE: E13181 MW, YH a hemorrhage AE that has bleeding from the prostate gland. prostatic obstruction AE 10055026 MW, YH a prostatic disorder AE that has compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder). CTCAE: E13187 NCIt: C78573 prostatic pain AE 10036968 NCIt: C78574 a pain AE that has a sensation of marked discomfort in the prostate gland. CTCAE: E13191 MW, YH psychosis AE 10037234 MW, YH NCIt: C78576 a psychiatric disorder AE that has personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor. CTCAE: E12954 pulmonary fistula AE 10065873 a fistula AE that has an abnormal communication between the lung and another organ or anatomic site. CTCAE: E13533 MW, YH NCIt: C78577 radiculitis AE 10061928 MW, YH an inflammation AE that has inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root. NCIt: C78581 CTCAE: E12786 recurrent laryngeal nerve palsy AE 10038130 NCIt: C78592 CTCAE: E12792 MW, YH a recurrent alsy AE that occurs at the laryngeal nerve. renal colic AE 10038419 NCIt: C78593 CTCAE: E13024 a renal calculus AE that has paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones. MW, YH renal hemorrhage AE 10038463 MW, YH a hemorrhage AE that has bleeding from the kidney. CTCAE: E13028 NCIt: C78594 retinoic acid syndrome AE 10038921 NCIt: C78597 MW, YH CTCAE: E13554 a syndrome AE that has weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid. scoliosis AE 10039722 CTCAE: E12521 NCIt: C78603 a bone disorder AE that has a malformed, lateral curvature of the spine. MW, YH scrotal pain AE 10039757 NCIt: C78607 a pain AE that has marked discomfort sensation in the scrotal area. MW, YH CTCAE: E13201 sinus pain AE 10040747 CTCAE: E12810 a pain AE that has marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses. NCIt: C78609 MW, YH skin induration AE 10051837 CTCAE: E13724 MW, YH an induration AE that has an area of hardness in the skin. NCIt: C78611 soft tissue necrosis lower limb AE 10065777 NCIt: C78620 CTCAE: E12525 MW, YH a necrosis AE that has a necrotic process occurring in the soft tissues of the lower extremity. soft tissue necrosis upper limb AE 10065778 MW, YH a necrosis AE that has a necrotic process occurring in the soft tissues of the upper extremity. CTCAE: E12530 NCIt: C78621 spermatic cord hemorrhage AE 10065762 NCIt: C78623 MW, YH a hemorrhage AE that has bleeding from the spermatic cord. CTCAE: E13205 spermatic cord obstruction AE 10065805 NCIt: C78624 MW, YH a male reproductive system AE that has blockage of the normal flow of the contents of the spermatic cord. CTCAE: E13211 superficial soft tissue fibrosis AE 10065798 a connective tissue disorder AE that has fibrotic degeneration of the superficial soft tissues. NCIt: C78633 MW, YH CTCAE: E12535 testicular hemorrhage AE 10055347 MW, YH NCIt: C78635 a hemorrhage AE that has bleeding from the testis. CTCAE: E13221 testicular pain AE 10043345 MW, YH a pain AE that has a sensation of marked discomfort in the testis. CTCAE: E13227 NCIt: C78636 tracheal fistula AE 10065787 MW, YH a fistula AE that hasan abnormal communication between the trachea and another organ or anatomic site. CTCAE: E13583 NCIt: C78641 tracheal mucositis AE 10065900 an inflammation AE that has an inflammation involving the mucous membrane of the trachea. MW, YH NCIt: C78644 CTCAE: E13589 tracheal stenosis AE 10050816 NCIt: C78646 CTCAE: E13595 a respiratory system AE that has a narrowing of the trachea. MW, YH tumor pain AE 10045158 a pain AE that has marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis. MW, YH CTCAE: E12565 NCIt: C78656 unequal limb length AE 10065738 NCIt: C78657 a musculoskeletal and connective tissue AE that hasa discrepancy between the lengths of the lower or upper extremities. MW, YH CTCAE: E12545 urine discoloration AE 10046628 MW, YH an urine abnormality AE that has a change in the color of the urine. CTCAE: E13065 NCIt: C78678 uterine fistula AE 10065811 a fistula AE that has an abnormal communication between the uterus and another organ or anatomic site. NCIt: C78685 CTCAE: E13231 MW, YH uterine obstruction AE 10065928 MW, YH an urinary system AE that has blockage of the uterine outlet. CTCAE: E13243 NCIt: C78693 uterine pain AE 10046809 NCIt: C78694 MW, YH a pain AE that has a sensation of marked discomfort in the uterus. CTCAE: E13247 vaginal dryness AE 10046904 MW, YH NCIt: C78699 a female reproductive system AE that has an uncomfortable feeling of itching and burning in the vagina. CTCAE: E13254 vaginal obstruction AE 10065817 CTCAE: E13276 NCIt: C78700 a female reproductive system AE that has blockage of vaginal canal. MW, YH vaginal pain AE 10046937 MW, YH CTCAE: E13280 a pain AE that has a sensation of marked discomfort in the vagina. NCIt: C78701 vaginal perforation AE 10065818 CTCAE: E13284 NCIt: C78702 a female reproductive system AE that has a rupture in the vaginal wall. MW, YH vaginismus AE 10046947 CTCAE: E13295 NCIt: C78703 a female reproductive system AE that hasinvoluntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse. MW, YH visceral arterial ischemia AE 10054692 NCIt: C78712 an ischemia AE that has a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery. MW, YH CTCAE: E13843 body odor AE 10005901 a skin AE that has an abnormal body smell resulting from the growth of bacteria on the body. MW, YH CTCAE: E13614 NCIt: C79542 bronchial fistula AE 10006437 NCIt: C79543 MW, YH a fistula AE that has an abnormal communication between the bronchus and another organ or anatomic site. CTCAE: E13322 extrapyramidal disorder AE 10015832 NCIt: C79593 CTCAE: E12658 MW, YH a nervous system AE that has an abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. hypertrichosis AE 10020864 MW, YH CTCAE: E13649 a hair growth abnormal AE that has hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race. NCIt: C79597 lactation disorder AE 10061261 NCIt: C79606 a female reproductive system AE that has disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males. CTCAE: E13129 MW, YH laryngeal stenosis AE 10023862 MW, YH CTCAE: E13427 a respiratory system AE that has a narrowing of the laryngeal airway. NCIt: C79608 meningismus AE 10027198 MW, YH CTCAE: E12722 a nervous system AE that has neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges. NCIt: C79694 phantom pain AE 10056238 MW, YH CTCAE: E12774 a pain AE that has marked discomfort related to a limb or an organ that is removed from or is not physically part of the body. NCIt: C79703 scalp pain AE 10049120 NCIt: C79716 a pain AE that has marked discomfort sensation in the skin covering the top and the back of the head. CTCAE: E13704 MW, YH unintended pregnancy AE 10045542 CTCAE: E12872 a pregnancy AE that has an unexpected pregnancy at the time of conception. NCIt: C79801 MW, YH urinary tract obstruction AE 10061574 MW, YH CTCAE: E13052 an urinary system AE that has blockage of the normal flow of contents of the urinary tract. NCIt: C79805 vaginal fistula AE 10065813 CTCAE: E13258 NCIt: C79847 a fistula AE that has an abnormal communication between the vagina and another organ or anatomic site. MW, YH urinary fistula AE 10065368 MW, YH NCIt: C79850 CTCAE: E13034 a fistula AE that has an abnormal communication between any part of the urinary system and another organ or anatomic site. azoospermia AE 10003883 a male reproductive system AE that has laboratory test results that indicate complete absence of spermatozoa in the semen. CTCAE: E13067 MW, YH NCIt: C80076 chronic kidney disease AE 10064848 MW, YH CTCAE: E12988 a renal failure AE that has gradual and usually permanent loss of kidney function resulting in renal failure. NCIt: C80078 concentration impairment AE 10010250 NCIt: C80081 MW, YH a behavior and neurological AE that has a deterioration in the ability to concentrate. CTCAE: E12621 fetal growth retardation AE 10054746 MW, YH NCIt: C80083 a fetal disorder AE that has inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight. CTCAE: E12857 premature menopause AE 10036601 MW, YH a menstrual disorder AE that has ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive. NCIt: C80099 CTCAE: E13179 leukemia secondary to oncology chemotherapy AE 10048293 NCIt: C80691 a tumor AE that has leukemia arising as a result of the mutagenic effect of chemotherapy agents. CTCAE: E12549 MW, YH bronchopleural fistula AE 10053481 MW, YH NCIt: C80694 CTCAE: E13340 a fistula AE that has an abnormal communication between a bronchus and the pleural cavity. urinary tract pain AE 10062225 CTCAE: E13058 NCIt: C83493 a pain AE that has a sensation of marked discomfort in the urinary tract. MW, YH breast atrophy AE 10006179 MW, YH a female reproductive system AE that has underdevelopment of the breast. NCIt: C83494 CTCAE: E13069 medical procedure YH, SS a medical intervention that refers to any series of pre-defined steps that should be followed to achieve a desired result. WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm incision site AE an AE that occurs in an incision site. YH, SS incision site a medical intervention site that is used for incision for a surgery. YH, SS Grade 1 lymphedema AE CTCAE: E13803 a hymphedema AE that has trace thickening or faint discoloration YH, MW Grade 2 lymphedema AE YH, MW CTCAE: E13804 a hymphedema AE that has marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL Grade 1 superior vena cava syndrome AE CTCAE: E13820 a superior vena cava syndrome AE that has asymptomatic; incidental finding of SVC thrombosis YH, MW Grade 2 superior vena cava syndrome AE a superior vena cava syndrome AEthat has symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy) CTCAE: E13821 YH, MW Grade 3 superior vena cava syndrome AE a superior vena cava syndrome AE that has severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting) YH, MW CTCAE: E13822 Grade 4 superior vena cava syndrome AE a superior vena cava syndrome AE that has life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery) CTCAE: E13823 YH, MW Grade 1 thromboembolic event AE a thromboembolic event AE that has venous thrombosis (e.g., superficial thrombosis) YH, MW CTCAE: E13826 Grade 2 thromboembolic event AE a thromboembolic event AE that has venous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated YH, MW CTCAE: E13827 Grade 3 thromboembolic event AE YH, MW CTCAE: E13828 a thromboembolic event AE that has thrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus), medical intervention indicated Grade 4 thromboembolic event AE a thromboembolic event AE that has life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated CTCAE: E13829 YH, MW Grade 2 visceral arterial ischemia AE a visceral arterial ischemia AE that has brief (<24 hrs) episode of ischemia managed medically and without permanent deficit YH, MW CTCAE: E13844 Grade 3 visceral arterial ischemia AE CTCAE: E13845 a visceral arterial ischemia AE that has prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated YH, MW Grade 1 menopause AE YH, MW a menopause AE that the menopause occurres at age 46 - 53 years of age CTCAE: E13751 Grade 2 menopause AE a menopause AE that the menopause occurres at age 40 - 45 years of age CTCAE: E13752 YH, MW Grade 3 menopause AE CTCAE: E13753 a menopause AE that the menopause occurres before age 40 years of age YH, MW Grade 1 body odor AE a body odor AE that has mild odor; physician intervention not indicated; self care interventions YH, MW CTCAE: E13615 Grade 2 body odor AE CTCAE: E13616 YH, MW a body odor AE that has pronounced odor; psychosocial impact; patient seeks medical intervention Grade 1 bullous dermatitis AE YH, MW CTCAE: E13618 a bullous AE that has asymptomatic; blisters covering <10% BSA Grade 2 bullous dermatitis AE YH, MW a bullous AE that has blisters covering 10 - 30% BSA; painful blisters; limiting instrumental ADL CTCAE: E13619 Grade 3 bullous dermatitis AE YH, MW a bullous AE that has blisters covering >30% BSA; limiting self care ADL CTCAE: E13620 Grade 4 bullous dermatitis AE CTCAE: E13621 a bullous AE that has blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated YH, MW Grade 2 erythroderma AE YH, MW an erythroderma AE that has erythema covering >90% BSA without associated symptoms; limiting instrumental ADL CTCAE: E13634 Grade 3 erythroderma AE an erythroderma AE that has erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL CTCAE: E13635 YH, MW Grade 4 erythroderma AE YH, MW an erythroderma AE that has erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated CTCAE: E13636 Grade 1 fat atrophy AE a fat atrophy AE that is covering <10% BSA and asymptomatic YH, MW CTCAE: E13639 Grade 2 fat atrophy AE a fat atrophy AE that is covering 10 - 30% BSA and associated with erythema or tenderness; limiting instrumental ADL CTCAE: E13640 YH, MW Grade 3 fat atrophy AE CTCAE: E13641 a fat atrophy AE that is covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL YH, MW Grade 1 hirsutism AE a hirsutism AE that is In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair YH, MW CTCAE: E13643 Grade 2 hirsutism AE a hirsutism AE that In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact YH, MW CTCAE: E13644 Grade 1 hypertrichosis AE a hypertrichosis AE that has increased in length, thickness or density of hair. The patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal YH, MW CTCAE: E13650 Grade 2 hypertrichosis AE CTCAE: E13651 YH, MW a hypertrichosis AE that has increased in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact Grade 3 hypohidrosis AE a hypertrichosis AE that has increased in body temperature; limiting self care ADL CTCAE: E13654 YH, MW Grade 4 hypohidrosis AE YH, MW a hypertrichosis AE that has heat stroke CTCAE: E13655 Grade 1 lipohypertrophy AE a lipohypertrophy AE that has asymptomatic and covering <10% BSA CTCAE: E13658 YH, MW Grade 2 lipohypertrophy AE YH, MW CTCAE: E13659 a lipohypertrophy AE that covers 10 - 30% BSA and associated tenderness; limiting instrumental ADL Grade 3 lipohypertrophy AE YH, MW a lipohypertrophy AE that covers >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL CTCAE: E13660 Grade 1 nail loss AE a nail loss AE that has asymptomatic separation of the nail bed from the nail plate or nail loss CTCAE: E13664 YH, MW Grade 2 nail loss AE YH, MW CTCAE: E13665 a nail loss AE that has symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL Grade 1 rash acneiform AE CTCAE: E13695 a rash acneiform AE that has papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness YH, MW Grade 2 rash acneiform AE YH, MW CTCAE: E13696 a rash acneiform AE that has papules and/or pustules covering 10 - 30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL Grade 3 rash acneiform AE a rash acneiform AE that has papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self care ADL; associated with local superinfection with oral antibiotics indicated YH, MW CTCAE: E13697 Grade 4 rash acneiform AE CTCAE: E13698 a rash acneiform AE that has papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences YH, MW Grade 1 rash maculo-papular AE CTCAE: E13701 YH, MW a rash maculopapular AE that has macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness) Grade 2 rash maculo-papular AE YH, MW a rash maculopapular AE that has macules/papules covering 10 - 30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL CTCAE: E13702 Grade 3 rash maculo-papular AE CTCAE: E13703 a rash maculopapular AE that has macules/papules covering >30% BSA with or without associated symptoms; limiting self care ADL YH, MW Grade 1 skin induration AE YH, MW a skin induration AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) CTCAE: E13725 Grade 2 skin induration AE YH, MW CTCAE: E13726 a skin induration AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL Grade 3 skin induration AE CTCAE: E13727 YH, MW a skin induration AE that has severe induration, unable to slide or pinch skin; limiting joint movement or orifice (e.g., mouth, anus); limiting self care ADL Grade 4 skin induration AE a skin induration AE that has generalized; associated with signs or symptoms of impaired breathing or feeding YH, MW CTCAE: E13728 Grade 2 bronchial fistula AE CTCAE: E13324 a bronchial fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL YH, MW Grade 3 bronchial fistula AE YH, MW CTCAE: E13325 a bronchial fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) Grade 4 bronchial fistula AE YH, MW a bronchial fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated CTCAE: E13326 Grade 2 bronchial obstruction AE CTCAE: E13330 YH, MW a bronchial obstruction AE that has symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators) Grade 3 bronchial obstruction AE a bronchial obstruction AE that has shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) CTCAE: E13331 YH, MW Grade 2 bronchial stricture AE YH, MW CTCAE: E13336 a bronchial stricture AE that AE symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators) Grade 3 bronchial stricture AE CTCAE: E13337 a bronchial stricture AE that AE shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) YH, MW Grade 3 bronchopleural fistula AE YH, MW CTCAE: E13343 a bronchopleural fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) Grade 4 bronchopleural fistula AE CTCAE: E13344 a bronchopleural fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated YH, MW Grade 2 laryngeal fistula AE a laryngeal fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL YH, MW CTCAE: E13401 Grade 3 laryngeal fistula AE a laryngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW CTCAE: E13402 Grade 4 laryngeal fistula AE YH, MW a laryngeal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) CTCAE: E13403 Grade 1 laryngeal hemorrhage AE a laryngeal hemorrhage AE that has mild cough or trace hemoptysis; laryngoscopic findings YH, MW CTCAE: E13406 Grade 1 laryngeal inflammation AE a laryngeal inflammation AE that has mild sore throat; raspy voice YH, MW CTCAE: E13412 Grade 2 laryngeal inflammation AE YH, MW a laryngeal inflammation AE that has moderate sore throat; analgesics indicated CTCAE: E13413 Grade 3 laryngeal inflammation AE CTCAE: E13414 a laryngeal inflammation AE that has severe throat pain; endoscopic intervention indicated YH, MW Grade 1 laryngeal mucositis AE YH, MW a laryngeal mucositis AE that has endoscopic findings only; mild discomfort with normal intake CTCAE: E13416 Grade 2 laryngeal mucositis AE CTCAE: E13417 a laryngeal mucositis AE that has moderate discomfort; altered oral intake YH, MW Grade 3 laryngeal mucositis AE CTCAE: E13418 YH, MW a laryngeal mucositis AE that has severe pain; severely altered eating/swallowing; medical intervention indicated Grade 4 laryngeal mucositis AE CTCAE: E13419 YH, MW a laryngeal mucositis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 2 laryngeal obstruction AE a laryngeal obstruction AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL YH, MW CTCAE: E13423 Grade 3 laryngeal obstruction AE a laryngeal obstruction AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) CTCAE: E13424 YH, MW Grade 2 laryngeal stenosis AE CTCAE: E13429 YH, MW a laryngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) Grade 3 laryngeal stenosis AE CTCAE: E13430 YH, MW a laryngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) Grade 2 laryngopharyngeal dysesthesia AE a laryngopharyngeal dysesthesia AE that has moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and or anxiolytic indicated; limiting instrumental ADL YH, MW CTCAE: E13435 Grade 3 laryngopharyngeal dysesthesia AE YH, MW a laryngopharyngeal dysesthesia AE that has severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL CTCAE: E13436 Grade 2 laryngospasm AE YH, MW CTCAE: E13440 a laryngospasm AE that has transient episode; intervention not indicated Grade 3 laryngospasm AE CTCAE: E13441 a laryngospasm AE that has recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage) YH, MW Grade 4 laryngospasm AE a laryngospasm AE that has persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection) CTCAE: E13442 YH, MW Grade 2 pharyngeal fistula AE YH, MW CTCAE: E13456 a pharyngeal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL Grade 3 pharyngeal fistula AE CTCAE: E13457 a pharyngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW Grade 1 pharyngeal mucositis AE a pharyngeal mucositis AE that has endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated CTCAE: E13467 YH, MW Grade 2 pharyngeal mucositis AE a pharyngeal mucositis AE that has moderate pain and analgesics indicated; altered oral intake; limiting instrumental ADL CTCAE: E13468 YH, MW Grade 3 pharyngeal mucositis AE CTCAE: E13469 a pharyngeal mucositis AE that has severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL YH, MW Grade 3 pharyngeal necrosis AE CTCAE: E13473 YH, MW a pharyngeal necrosis AE that has inability to aliment adequately by GI tract; tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated Grade 2 pharyngeal stenosis AE CTCAE: E13478 YH, MW a pharyngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL Grade 3 pharyngeal stenosis AE YH, MW a pharyngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) CTCAE: E13479 Grade 4 pharyngeal stenosis AE a pharyngeal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW CTCAE: E13480 Grade 2 pulmonary fistula AE CTCAE: E13535 a pulmonary fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL YH, MW Grade 3 pulmonary fistula AE a pulmonary fistula AE that has limiting self care ADL; endoscopic stenting or operative intervention indicated CTCAE: E13536 YH, MW Grade 1 retinoic acid syndrome AE a retinoic acid syndrome AE that has fluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated YH, MW CTCAE: E13555 Grade 1 sleep apnea AE a sleep apnea AE that has snoring and nocturnal sleep arousal without apneic periods CTCAE: E13567 YH, MW Grade 2 sleep apnea AE YH, MW a sleep apnea AE that has moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL CTCAE: E13568 Grade 3 sleep apnea AE YH, MW CTCAE: E13569 a sleep apnea AE that has oxygen desaturation; associated with hypertension; medical intervention indicated; limiting self care ADL Grade 4 sleep apnea AE a sleep apnea AE that has cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated CTCAE: E13570 YH, MW Grade 2 tracheal fistula AE CTCAE: E13585 YH, MW a tracheal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL Grade 3 tracheal fistula AE a tracheal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) YH, MW CTCAE: E13586 Grade 4 tracheal fistula AE YH, MW CTCAE: E13587 a tracheal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) Grade 1 tracheal mucositis AE CTCAE: E13590 YH, MW a tracheal mucositis AE that has endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms Grade 3 tracheal mucositis AE YH, MW a tracheal mucositis AE that has severe pain; hemorrhage or respiratory symptoms; limiting self care ADL CTCAE: E13592 Grade 2 tracheal stenosis AE CTCAE: E13597 YH, MW a tracheal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) Grade 3 tracheal stenosis AE YH, MW CTCAE: E13598 a tracheal stenosis AE that has stridor or respiratory distress limiting self care ADL; endoscopic intervention indicated (e.g., stent, laser) Grade 4 tracheal stenosis AE CTCAE: E13599 a tracheal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 3 azoospermia AE an azoospermia AE that has absence of sperm in ejaculate CTCAE: E13068 YH, MW Grade 3 breast atrophy AE A breast atrophy AE that has asymmetry >1/3 of breast volume; severe atrophy YH, MW CTCAE: E13072 Grade 1 ejaculation disorder AE an ejaculation disorder AE that has diminished ejaculation CTCAE: E13086 YH, MW Grade 2 ejaculation disorder AE YH, MW CTCAE: E13087 an ejaculation disorder AE that has anejaculation or retrograde ejaculation Grade 1 genital edema AE CTCAE: E13112 a genital edema AE that has mild swelling or obscuration of anatomic architecture on close inspection YH, MW Grade 2 genital edema AE YH, MW CTCAE: E13113 a genital edema AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour Grade 3 genital edema AE CTCAE: E13114 a genital edema AE that has lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL YH, MW Grade 1 gynecomastia AE YH, MW CTCAE: E13116 a gynecomastia AE that has asymptomatic breast enlargement Grade 2 gynecomastia AE CTCAE: E13117 a gynecomastia AE that has symptomatic (e.g., pain or psychosocial impact) YH, MW Grade 1 hematosalpinx AE CTCAE: E13120 YH, MW a hematosalpinx AE that has minimal bleeding identified on imaging study or laparoscopy; intervention not indicated Grade 1 irregular menstruation AE CTCAE: E13126 YH, MW an irregular menstruation AE that has intermittent menses with skipped menses for no more than 1 to 3 months Grade 2 irregular menstruation AE an irregular menstruation AE that has intermittent menses with skipped menses for more than 4 to 6 months YH, MW CTCAE: E13127 Grade 3 irregular menstruation AE YH, MW an irregular menstruation AE that has persistent amenorrhea for more than 6 months CTCAE: E13128 Grade 1 lactation disorder AE CTCAE: E13130 YH, MW a lactation disorder AE that has mild changes in lactation, not significantly affecting production or expression of breast milk Grade 2 lactation disorder AE YH, MW CTCAE: E13131 a lactation disorder AE that has changes in lactation, significantly affecting breast production or expression of breast milk Grade 1 nipple deformity AE CTCAE: E13139 a nipple deformity AE that has asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex YH, MW Grade 2 nipple deformity AE CTCAE: E13140 a nipple deformity AE that has symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex YH, MW Grade 1 oligospermia AE CTCAE: E13142 an oligospermia AE requires sperm concentration >48 million/mL or motility >68% YH, MW Grade 2 oligospermia AE YH, MW CTCAE: E13143 an oligospermia AE requires sperm concentration 13 - 48 million/mL or motility 32 - 68% Grade 3 oligospermia AE CTCAE: E13144 an oligospermia AE requires sperm concentration <13 million/mL or motility <32% YH, MW Grade 2 testicular disorder AE CTCAE: E13217 YH, MW a testicular disorder AE that has symptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL Grade 3 testicular disorder AE a testicular disorder AE that has severe symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated CTCAE: E13218 YH, MW Grade 1 vaginal discharge AE a vaginal discharge AE that has mild vaginal discharge (greater than baseline for patient) CTCAE: E13252 YH, MW Grade 2 vaginal discharge AE a vaginal discharge AE that has moderate to heavy vaginal discharge; use of perineal pad or tampon indicated YH, MW CTCAE: E13253 Grade 2 bladder spasm AE YH, MW CTCAE: E12986 a bladder spasm AE that has antispasmodics indicated Grade 3 bladder spasm AE YH, MW a bladder spasm AE that has hospitalization indicated CTCAE: E12987 Grade 1 chronic kidney disease AE CTCAE: E12989 a chronic kidney disease AE that requires eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN - 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5 YH, MW Grade 2 chronic kidney disease AE YH, MW CTCAE: E12990 a chronic kidney disease AE that requires eGFR or CrCl 59 - 30 ml/min/1.73 m2 Grade 3 chronic kidney disease AE CTCAE: E12991 a chronic kidney disease AE that requires eGFR or CrCl 29 - 15 ml/min/1.73 m2 YH, MW Grade 4 chronic kidney disease AE YH, MW CTCAE: E12992 a chronic kidney disease AE that requires eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated Grade 1 cystitis noninfective AE a cystitis noninfective AE that has microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence YH, MW CTCAE: E12995 Grade 2 cystitis noninfective AE a cystitis noninfective AE that has moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL CTCAE: E12996 YH, MW Grade 3 cystitis noninfective AE CTCAE: E12997 a cystitis noninfective AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated YH, MW Grade 1 proteinuria AE a proteinuria AE that requires 1+ proteinuria; urinary protein <1.0 g/24 hrs YH, MW CTCAE: E13009 Grade 2 proteinuria AE YH, MW CTCAE: E13010 a proteinuria AE that requires Grade 3 proteinuria AE CTCAE: E13011 a proteinuria AE that requires YH, MW Grade 1 renal calculi AE YH, MW CTCAE: E13019 a renal calculi AE that has asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated Grade 2 renal calculi AE a renal calculi AE that has symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated CTCAE: E13020 YH, MW Grade 3 renal calculi AE YH, MW a renal calculi AE that has hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated CTCAE: E13021 Grade 2 urinary fistula AE CTCAE: E13035 YH, MW an urinary fistula AE that has noninvasive intervention indicated; urinary or suprapubic catheter placement indicated Grade 3 urinary fistula AE YH, MW CTCAE: E13036 an urinary fistula AE that has limiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated Grade 2 urinary tract obstruction AE an urinary tract obstruction AE that has symptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated CTCAE: E13054 YH, MW Grade 3 urinary tract obstruction AE YH, MW an urinary tract obstruction AE that has symptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic or operative intervention indicated CTCAE: E13055 Grade 1 mania AE CTCAE: E12937 YH, MW a mania AE that has mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep) Grade 2 mania AE CTCAE: E12938 YH, MW a mania AE that has moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene) Grade 3 mania AE YH, MW a mania AE that has severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated CTCAE: E12939 Grade 2 fetal growth retardation AE a fetal growth retardation AE that has <10% percentile of weight for gestational age YH, MW CTCAE: E12858 Grade 3 fetal growth retardation AE a fetal growth retardation AE that has <5% percentile of weight for gestational age CTCAE: E12859 YH, MW Grade 4 fetal growth retardation AE a fetal growth retardation AE that has <1% percentile of weight for gestational age CTCAE: E12860 YH, MW Grade 1 premature delivery AE CTCAE: E12868 YH, MW a premature delivery AE that has delivery of a liveborn infant at >34 to 37 weeks gestation Grade 2 premature delivery AE a premature delivery AE that has delivery of a liveborn infant at >28 to 34 weeks gestation CTCAE: E12869 YH, MW Grade 3 premature delivery AE YH, MW a premature delivery AE that has delivery of a liveborn infant at 24 to 28 weeks gestation CTCAE: E12870 Grade 4 premature delivery AE CTCAE: E12871 YH, MW a premature delivery AE that has delivery of a liveborn infant at 24 weeks of gestation or less Grade 1 spasticity AE a spasticity AE that has mild or slight increase in muscle tone CTCAE: E12821 YH, MW Grade 2 spasticity AE a spasticity AE that has moderate increase in muscle tone and increase in resistance through range of motion CTCAE: E12822 YH, MW Grade 3 spasticity AE a spasticity AE that has severe increase in muscle tone and increase in resistance through range of motion YH, MW CTCAE: E12823 Grade 4 spasticity AE YH, MW a spasticity AE that has life-threatening; unable to move active or passive range of motion CTCAE: E12824 Grade 3 treatment related secondary malignancy AE CTCAE: E12562 YH, MW a treatment related secondary malignancy AE that has non life-threatening secondary malignancy Grade 4 treatment related secondary malignancy AE a treatment related secondary malignancy AE that has acute life-threatening secondary malignancy; blast crisis in leukemia YH, MW CTCAE: E12563 Grade 2 abdominal soft tissue necrosis AE YH, MW an abdominal soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) CTCAE: E12370 Grade 3 abdominal soft tissue necrosis AE CTCAE: E12371 an abdominal soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g. tissue reconstruction, flap or grafting) YH, MW Grade 1 fibrosis deep connective tissue AE YH, MW a fibrosis deep connective tissue AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) CTCAE: E12409 Grade 2 fibrosis deep connective tissue AE a fibrosis deep connective tissue AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL CTCAE: E12410 YH, MW Grade 3 fibrosis deep connective tissue AE YH, MW a fibrosis deep connective tissue AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g. mouth, anus); limiting self care ADL CTCAE: E12411 Grade 4 fibrosis deep connective tissue AE a fibrosis deep connective tissue AE that has generalized; associated with signs or symptoms of impaired breathing or feeding CTCAE: E12412 YH, MW Grade 1 growth suppression AE YH, MW CTCAE: E12423 a growth suppression AE that has reduction in growth velocity by 10 - 29% ideally measured over the period of a year Grade 2 growth suppression AE CTCAE: E12424 YH, MW a growth suppression AE that has reduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve Grade 3 growth suppression AE CTCAE: E12425 YH, MW a growth suppression AE that has reduction in growth velocity of >=50% ideally measured over the period of a year Grade 2 head soft tissue necrosis AE a head soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) YH, MW CTCAE: E12427 Grade 3 head soft tissue necrosis AE CTCAE: E12428 a head soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 1 joint range of motion decreased cervical spine AE CTCAE: E12440 a joint range of motion decreased cervical spine AE that has mild restriction of rotation or flexion between 60 - 70 degrees YH, MW Grade 2 joint range of motion decreased cervical spine AE a joint range of motion decreased cervical spine AE that has rotation <60 degrees to right or left; <60 degrees of flexion YH, MW CTCAE: E12441 Grade 3 joint range of motion decreased cervical spine AE CTCAE: E12442 YH, MW a joint range of motion decreased cervical spine AE that has ankylosed/fused over multiple segments with no C-spine rotation Grade 1 joint range of motion decreased lumbar spine AE CTCAE: E12444 YH, MW a joint range of motion decreased lumbar spine AE that has stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity Grade 2 joint range of motion decreased lumbar spine AE YH, MW a joint range of motion decreased lumbar spine AE that has pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor CTCAE: E12445 Grade 3 joint range of motion decreased lumbar spine AE CTCAE: E12446 YH, MW a joint range of motion decreased lumbar spine AE that requires <50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object) Grade 2 neck soft tissue necrosis AE YH, MW a neck soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) CTCAE: E12498 Grade 3 neck soft tissue necrosis AE CTCAE: E12499 YH, MW a neck soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) Grade 2 pelvic soft tissue necrosis AE YH, MW CTCAE: E12517 a pelvic soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 3 pelvic soft tissue necrosis AE YH, MW a pelvic soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) CTCAE: E12518 Grade 1 scoliosis AE CTCAE: E12522 a scoliosis AE that requires <20 degrees; clinically undetectable YH, MW Grade 2 scoliosis AE CTCAE: E12523 a scoliosis AE that requires >20 - 45 degrees; visible by forward flexion; limiting instrumental ADL YH, MW Grade 3 scoliosis AE a scoliosis AE that requires >45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL; disabling CTCAE: E12524 YH, MW Grade 2 soft tissue necrosis lower limb AE YH, MW CTCAE: E12526 a soft tissue necrosis lower limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) Grade 3 soft tissue necrosis lower limb AE CTCAE: E12527 a soft tissue necrosis lower limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 2 soft tissue necrosis upper limb AE YH, MW a soft tissue necrosis upper limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) CTCAE: E12531 Grade 3 soft tissue necrosis upper limb AE CTCAE: E12532 a soft tissue necrosis upper limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) YH, MW Grade 1 superficial soft tissue fibrosis AE a Superficial soft tissue fibrosis AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) YH, MW CTCAE: E12536 Grade 2 superficial soft tissue fibrosis AE CTCAE: E12537 a Superficial soft tissue fibrosis AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL YH, MW Grade 3 superficial soft tissue fibrosis AE CTCAE: E12538 a Superficial soft tissue fibrosis AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL YH, MW Grade 4 superficial soft tissue fibrosis AE CTCAE: E12539 a superficial soft tissue fibrosis AE that has generalized; associated with signs or symptoms of impaired breathing or feeding YH, MW Grade 1 trismus AE YH, MW CTCAE: E12542 a trismus AE that has decreased ROM (range of motion) without impaired eating Grade 2 trismus AE a trismus AE that has decreased ROM requiring small bites, soft foods or purees YH, MW CTCAE: E12543 Grade 3 trismus AE a trismus AE that has decreased ROM with inability to adequately aliment or hydrate orally YH, MW CTCAE: E12544 Grade 1 unequal limb length AE YH, MW An unequal limb length AE that has mild length discrepancy <2 cm CTCAE: E12546 Grade 2 unequal limb length AE CTCAE: E12547 An unequal limb length AE that has moderate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL YH, MW Grade 3 unequal limb length AE YH, MW CTCAE: E12548 An unequal limb length AE that has severe length discrepancy >5 cm; limiting self care ADL; disabling; operative intervention indicated Grade 1 alkalosis AE a alkalosis AE that requires pH >normal, but <=7.5 CTCAE: E12248 YH, MW Grade 3 alkalosis AE CTCAE: E12249 a alkalosis AE that requires pH >7.5 YH, MW Grade 2 glucose intolerance AE CTCAE: E12266 a glucose intolerance AE that has symptomatic; dietary modification or oral agent indicated YH, MW Grade 3 glucose intolerance AE YH, MW CTCAE: E12267 a glucose intolerance AE that has severe symptoms; insulin indicated Grade 1 hypermagnesemia AE a hypermagnesemia AE that requires >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L YH, MW CTCAE: E12289 Grade 3 hypermagnesemia AE YH, MW a hypermagnesemia AE that requires >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L CTCAE: E12290 Grade 4 hypermagnesemia AE YH, MW CTCAE: E12291 a hypermagnesemia AE that requires >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences Grade 1 hypernatremia AE CTCAE: E12294 YH, MW a hypernatremia AE that requires >ULN - 150 mmol/L Grade 2 hypernatremia AE a hypernatremia AE that requires >150 - 155 mmol/L YH, MW CTCAE: E12295 Grade 3 hypernatremia AE CTCAE: E12296 a hypernatremia AE that requires >155 - 160 mmol/L; hospitalization indicated YH, MW Grade 4 hypernatremia AE YH, MW CTCAE: E12297 a hypernatremia AE that requires >160 mmol/L; life-threatening consequences Grade 1 hypokalemia AE a hypokalemia AE that requires <LLN - 3.0 mmol/L YH, MW CTCAE: E12328 Grade 2 hypokalemia AE CTCAE: E12329 YH, MW a hypokalemia AE that requires <LLN - 3.0 mmol/L; symptomatic; intervention indicated Grade 3 hypokalemia AE CTCAE: E12330 a hypokalemia AE that requires <3.0 - 2.5 mmol/L; hospitalization indicated YH, MW Grade 4 hypokalemia AE a hypokalemia AE that requires <2.5 mmol/L; life-threatening consequences YH, MW CTCAE: E12331 Grade 1 hyponatremia AE CTCAE: E12340 a hyponatremia AE that requires <LLN - 130 mmol/L YH, MW Grade 3 hyponatremia AE a hyponatremia AE that requires <130 - 120 mmol/L CTCAE: E12341 YH, MW Grade 4 hyponatremia AE YH, MW a hyponatremia AE that requires <120 mmol/L; life-threatening consequences CTCAE: E12342 Grade 2 obesity AE CTCAE: E12362 an obesity AE that requires BMI 25 - 29.9 kg/m2 YH, MW Grade 3 obesity AE YH, MW an obesity AE that requires BMI 30 - 39.9 kg/m2 CTCAE: E12363 Grade 4 obesity AE CTCAE: E12364 an obesity AE that requires BMI >=40 kg/m2 YH, MW Grade 3 flushing AE YH, MW CTCAE: E13774 a flushing AE that has symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL Grade 2 hematoma AE a hematoma AE that requires minimally invasive evacuation or aspiration YH, MW CTCAE: E13777 Grade 3 hematoma AE a hematoma AE that requires transfusion, radiologic, endoscopic, or elective operative intervention YH, MW CTCAE: E13778 Grade 1 hypertension AE an hypertension AE that has prehypertension (systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg) CTCAE: E13786 YH, MW Grade 2 hypertension AE CTCAE: E13787 YH, MW an hypertension AE that for Adult: has stage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated; for Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated. Grade 3 hypertension AE an hypertension AE that for Adult has Stage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; for Pediatric: Same as adult. CTCAE: E13788 YH, MW Grade 4 hypertension AE CTCAE: E13789 YH, MW an hypertension AE that for Adult has life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated; for Pediatric: Same as adult Grade 2 peripheral ischemia AE YH, MW CTCAE: E13811 a peripheral ischaemia AE that has brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit Grade 3 peripheral ischemia AE a peripheral ischaemia AE that has a recurring or prolonged (>=24 hrs) and/or invasive intervention indicated YH, MW CTCAE: E13812 Grade 3 vasculitis AE YH, MW a vasculitis AE that shows severe symptoms, medical intervention indicated (e.g., steroids) CTCAE: E13840 Grade 4 vasculitis AE CTCAE: E13841 a vasculitis AE that shows threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated YH, MW Grade 1 alopecia AE an alopecia AE that has hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage YH, MW CTCAE: E13612 Grade 2 alopecia AE YH, MW an alopecia AE that has hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact CTCAE: E13613 Grade 1 dry skin AE YH, MW CTCAE: E13624 a dry skin AE that is coverying <10% BSA and no associated erythema or pruritus Grade 2 dry skin AE a dry skin AE that is coverying 10 - 30% BSA and associated with erythema or pruritus; limiting instrumental ADL CTCAE: E13625 YH, MW Grade 3 dry skin AE CTCAE: E13626 a dry skin AE that is coverying >30% BSA and associated with pruritus; limiting self care ADL YH, MW Grade 1 erythema multiforme AE an erythema multiforme AE that has target lesions covering <10% BSA and not associated with skin tenderness CTCAE: E13628 YH, MW Grade 2 erythema multiforme AE YH, MW CTCAE: E13629 an erythema multiforme AE that has target lesions covering 10 - 30% BSA and associated with skin tenderness Grade 3 erythema multiforme AE YH, MW an erythema multiforme AE that has target lesions covering >30% BSA and associated with oral or genital erosions CTCAE: E13630 Grade 4 erythema multiforme AE CTCAE: E13631 an erythema multiforme AE that has target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated YH, MW Grade 1 hyperhidrosis AE CTCAE: E13646 a hyperhidros AE that shows limited to one site (palms, soles, or axillae); self care interventions YH, MW Grade 2 hyperhidrosis AE YH, MW a hyperhidros AE that has Involving >1 site; patient seeks medical intervention; associated with psychosocial impact CTCAE: E13647 Grade 3 hyperhidrosis AE CTCAE: E13648 YH, MW a hyperhidros AE that has Generalized involving sites other than palms, soles, or axillae; associated with electrolyte/hemodynamic imbalance Grade 1 palmar-plantar erythrodysesthesia syndrome AE CTCAE: E13673 YH, MW a palmar-plantar erythrodysesthesia syndrome AE that has minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain Grade 2 palmar-plantar erythrodysesthesia syndrome AE CTCAE: E13674 YH, MW a palmar-plantar erythrodysesthesia syndrome AE that has skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL Grade 3 palmar-plantar erythrodysesthesia syndrome AE YH, MW CTCAE: E13675 a palmar-plantar erythrodysesthesia syndrome AE that has severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care ADL Grade 1 periorbital edema AE CTCAE: E13677 YH, MW a periorbital edema AE that has soft or non-pitting Grade 2 periorbital edema AE YH, MW a periorbital edema AE that has indurated or pitting edema; topical intervention indicated CTCAE: E13678 Grade 3 periorbital edema AE CTCAE: E13679 a periorbital edema AE that has edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated YH, MW Grade 1 photosensitivity AE CTCAE: E13681 a photosensitivity reaction AE that has painless erythema and erythema covering <10% BSA YH, MW Grade 2 photosensitivity AE a photosensitivity reaction AE that has tender erythema covering 10 - 30% BSA YH, MW CTCAE: E13682 Grade 3 photosensitivity AE a photosensitivity reaction AE that has erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs) CTCAE: E13683 YH, MW Grade 1 pruritus AE CTCAE: E13687 YH, MW a pruritus AE that has mild or localized; topical intervention indicated Grade 2 pruritus AE YH, MW CTCAE: E13688 a pruritus AE that has intense or widespread; intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL Grade 3 pruritus AE a pruritus AE that has intense or widespread; constant; limiting self care ADL or sleep; oral corticosteroid or immunosuppressive therapy indicated YH, MW CTCAE: E13689 Grade 1 purpura AE a purpura AE that has combined area of lesions covering <10% BSA YH, MW CTCAE: E13691 Grade 2 purpura AE CTCAE: E13692 YH, MW a purpura AE that has combined area of lesions covering 10 - 30% BSA; bleeding with trauma Grade 3 purpura AE a purpura AE that has combined area of lesions covering >30% BSA; spontaneous bleeding YH, MW CTCAE: E13693 Grade 1 skin atrophy AE YH, MW CTCAE: E13715 a skin atrophy AE that has covering <10% BSA; associated with telangiectasias or changes in skin color Grade 2 skin atrophy AE YH, MW CTCAE: E13716 a skin atrophy AE that has covering 10 - 30% BSA; associated with striae or adnexal structure loss Grade 3 skin atrophy AE YH, MW CTCAE: E13717 a skin atrophy AE that has covering >30% BSA; associated with ulceration Grade 1 skin hyperpigmentation AE YH, MW a skin hyperpigmentation AE that has hyperpigmentation covering <10% BSA; no psychosocial impact CTCAE: E13719 Grade 2 skin hyperpigmentation AE a skin hyperpigmentation AE that has hyperpigmentation covering >10% BSA; associated psychosocial impact YH, MW CTCAE: E13720 Grade 1 skin hypopigmentation AE CTCAE: E13722 a skin hypopigmentation AE that has hypopigmentation or depigmentation covering <10% BSA; no psychosocial impact YH, MW Grade 2 skin hypopigmentation AE CTCAE: E13723 a skin hypopigmentation AE that has hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact YH, MW Grade 3 stevens-Johnson syndrome AE a stevens-johnson syndrome AE that has skin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) YH, MW CTCAE: E13737 Grade 4 stevens-Johnson syndrome AE a stevens-johnson syndrome AE that has skin sloughing covering 10 - 30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) CTCAE: E13738 YH, MW Grade 1 telangiectasia AE YH, MW a telangiectasia AE that has telangiectasias covering <10% BSA CTCAE: E13741 Grade 2 telangiectasia AE a telangiectasia AE that has telangiectasias covering >10% BSA; associated with psychosocial impact CTCAE: E13742 YH, MW Grade 4 toxic epidermal necrolysis AE YH, MW a toxic epidermal necrolysis AE that has skin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment) CTCAE: E13744 Grade 1 urticaria AE CTCAE: E13747 YH, MW an urticaria AE that has urticarial lesions covering <10% BSA; topical intervention indicated Grade 2 urticaria AE CTCAE: E13748 YH, MW an urticaria AE that has urticarial lesions covering 10 - 30% BSA; oral intervention indicated Grade 3 urticaria AE CTCAE: E13749 an urticaria AE that has urticariallesions covering >30% BSA; IV intervention indicated YH, MW Grade 2 aspiration AE CTCAE: E13312 YH, MW an aspiration AE that has altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen) Grade 3 aspiration AE YH, MW an aspiration AE that has dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally CTCAE: E13313 Grade 2 atelectasis AE CTCAE: E13318 an atelectasis AE that has symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning YH, MW Grade 3 atelectasis AE an atelectasis AE that has oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser) YH, MW CTCAE: E13319 Grade 2 chylothorax AE a chylothorax AE that has symptomatic; thoracentesis or tube drainage indicated YH, MW CTCAE: E13360 Grade 3 chylothorax AE CTCAE: E13361 YH, MW a chylothorax AE that has severe symptoms; elective operative intervention indicated Grade 2 epistaxis AE an epistaxis AE that has moderate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors) YH, MW CTCAE: E13376 Grade 3 hiccups AE YH, MW CTCAE: E13383 a Hiccups AE that has interfering with sleep; limiting self care ADL Grade 1 hoarseness AE a hoarseness AE that has mild or intermittent voice change; fully understandable; self-resolves YH, MW CTCAE: E13385 Grade 2 hoarseness AE YH, MW CTCAE: E13386 a hoarseness AE that has Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated Grade 3 hoarseness AE CTCAE: E13387 a hoarseness AE that has severe voice changes including predominantly whispered speech YH, MW Grade 2 hypoxia AE CTCAE: E13389 YH, MW a hypoxia AE that has decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen Grade 3 hypoxia AE YH, MW a hypoxia AE that has decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg) CTCAE: E13390 Grade 4 hypoxia AE CTCAE: E13391 a hypoxia AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 3 laryngeal edema AE a laryngeal edema AE that has stridor; respiratory distress; hospitalization indicated CTCAE: E13396 YH, MW Grade 4 laryngeal edema AE a laryngeal edema AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW CTCAE: E13397 Grade 2 pleural effusion AE YH, MW a pleural effusion AE that has symptomatic; intervention indicated (e.g., diuretics or limited therapeutic thoracentesis) CTCAE: E13488 Grade 3 pleural effusion AE a pleural effusion AE that has symptomatic with respiratory distress and hypoxia; surgical intervention including chest tube or pleurodesis indicated CTCAE: E13489 YH, MW Grade 1 pleural hemorrhage AE YH, MW CTCAE: E13493 a pleural hemorrhage AE that has asymptomatic; mild hemorrhage confirmed by thoracentesis Grade 2 pleural hemorrhage AE a pleural hemorrhage AE that has symptomatic or associated with pneumothorax; chest tube drainage indicated YH, MW CTCAE: E13494 Grade 3 pleural hemorrhage AE a pleural hemorrhage AE that has >1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2 - 4 hr); persistent transfusion indicated; elective operative intervention indicated CTCAE: E13495 YH, MW Grade 3 pneumonitis AE YH, MW CTCAE: E13505 a pneumonitis AE that has severe symptoms; limiting self care ADL; oxygen indicated Grade 4 pneumonitis AE CTCAE: E13506 a pneumonitis AE that has life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 2 pneumothorax AE a pneumothorax AE that has symptomatic; intervention indicated (e.g., tube placement without sclerosis) YH, MW CTCAE: E13510 Grade 3 pneumothorax AE CTCAE: E13511 YH, MW a pneumothorax AE that has sclerosis and/or operative intervention indicated; hospitalization indicated Grade 1 productive cough AE YH, MW a productive cough AE that has occasional/minimal production of sputum with cough CTCAE: E13518 Grade 2 productive cough AE CTCAE: E13519 YH, MW a productive cough AE that has moderate sputum production; limiting instrumental ADL Grade 3 productive cough AE YH, MW CTCAE: E13520 a productive cough AE that has persistent or copious production of sputum; limiting self care ADL Grade 1 pulmonary edema AE CTCAE: E13522 YH, MW a pulmonary edema AE that has radiologic findings only; minimal dyspnea on exertion Grade 2 pulmonary edema AE YH, MW a pulmonary edema AE that has moderate dyspnea on exertion; medical intervention indicated; limiting instrumental ADL CTCAE: E13523 Grade 3 pulmonary edema AE CTCAE: E13524 YH, MW a pulmonary edema AE that has severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL Grade 4 pulmonary edema AE CTCAE: E13525 YH, MW a pulmonary edema AE that has life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated Grade 1 pulmonary fibrosis AE YH, MW a pulmonary fibrosis AE that has mild hypoxemia; radiologic pulmonary fibrosis <25% of lung volume CTCAE: E13528 Grade 2 pulmonary fibrosis AE CTCAE: E13529 a pulmonary fibrosis AE that has moderate hypoxemia; evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 - 50% YH, MW Grade 3 pulmonary fibrosis AE YH, MW CTCAE: E13530 a pulmonary fibrosis AE that has severe hypoxemia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50 - 75% Grade 4 pulmonary fibrosis AE YH, MW a pulmonary fibrosis AE that has life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing CTCAE: E13531 Grade 1 pulmonary hypertension AE a pulmonary hypertension AE that has minimal dyspnea; findings on physical exam or other evaluation YH, MW CTCAE: E13540 Grade 2 pulmonary hypertension AE a pulmonary hypertension AE that has moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention YH, MW CTCAE: E13541 Grade 3 pulmonary hypertension AE YH, MW CTCAE: E13542 a pulmonary hypertension AE that has severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated Grade 4 pulmonary hypertension AE CTCAE: E13543 a pulmonary hypertension AE that has life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation) YH, MW Grade 1 sinus disorder AE YH, MW CTCAE: E13561 a sinus disorder AE that has asymptomatic mucosal crusting; blood-tinged secretions Grade 2 sinus disorder AE CTCAE: E13562 a sinus disorder AE that has symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL YH, MW Grade 3 sinus disorder AE CTCAE: E13563 YH, MW a sinus disorder AE that has stenosis with significant nasal obstruction; limiting self care ADL Grade 4 sinus disorder AE CTCAE: E13564 YH, MW a sinus disorder AE that has necrosis of soft tissue or bone; urgent operative intervention indicated Grade 3 sore throat AE CTCAE: E13578 a sore throat AE that has Severe pain; limiting self care ADL; limiting ability to swallow YH, MW Grade 3 stridor AE YH, MW CTCAE: E13580 a stridor AE that has respiratory distress limiting self care ADL; medical intervention indicated Grade 4 stridor AE a stridor AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) CTCAE: E13581 YH, MW Grade 1 voice alteration AE YH, MW CTCAE: E13602 a voice alteration AE that has mild or intermittent change from normal voice Grade 2 voice alteration AE a voice alteration AE that has moderate or persistent change from normal voice; still understandable CTCAE: E13603 YH, MW Grade 3 voice alteration AE YH, MW a voice alteration AE that has severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology CTCAE: E13604 Grade 1 wheezing AE CTCAE: E13606 YH, MW a wheezing AE that has detectable airway noise with minimal symptoms Grade 3 wheezing AE YH, MW CTCAE: E13608 a wheezing AE that has severe respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated Grade 2 menorrhagia AE CTCAE: E13134 YH, MW a menorrhagia AE that has moderate symptoms; medical intervention indicated (e.g., hormones) Grade 3 menorrhagia AE a menorrhagia AE that has severe; transfusion indicated; surgical intervention indicated (e.g., hysterectomy) CTCAE: E13135 YH, MW Grade 1 acute kidney injury AE YH, MW an acute kidney injury AE that has creatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline CTCAE: E12974 Grade 2 acute kidney injury AE CTCAE: E12975 an acute kidney injury AE that has creatinine 2 - 3 x above baseline YH, MW Grade 3 acute kidney injury AE YH, MW an acute kidney injury AE that has creatinine >3 x baseline or >4.0 mg/dL; hospitalization indicated CTCAE: E12976 Grade 2 hematuria AE CTCAE: E13002 YH, MW a hematuria AE that has symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL Grade 3 hematuria AE CTCAE: E13003 YH, MW a hematuria AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated; limiting self care ADL Grade 1 urinary incontinence AE an urinary incontinence AE that has occasional (e.g., with coughing, sneezing, etc.), pads not indicated YH, MW CTCAE: E13043 Grade 2 urinary incontinence AE YH, MW CTCAE: E13044 an urinary incontinence AE that has spontaneous; pads indicated; limiting instrumental ADL Grade 3 urinary incontinence AE an urinary incontinence AE that has Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL YH, MW CTCAE: E13045 Grade 1 urinary retention AE an urinary retention AE that has urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual YH, MW CTCAE: E13047 Grade 2 urinary retention AE an urinary retention AE that has placement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated CTCAE: E13048 YH, MW Grade 3 urinary retention AE YH, MW CTCAE: E13049 an urinary retention AE that has elective operative or radiologic intervention indicated; substantial loss of affected kidney function or mass Grade 1 suicidal ideation AE YH, MW a suicidal ideation AE that has increased thoughts of death but no wish to kill oneself CTCAE: E12965 Grade 2 suicidal ideation AE CTCAE: E12966 YH, MW a suicidal ideation AE that has suicidal ideation with no specific plan or intent Grade 3 suicidal ideation AE YH, MW CTCAE: E12967 a suicidal ideation AE that has specific plan to commit suicide without serious intent to die which may not require hospitalization Grade 4 suicidal ideation AE CTCAE: E12968 a suicidal ideation AE that has specific plan to commit suicide with serious intent to die which requires hospitalization YH, MW Grade 3 suicide attempt AE YH, MW a suicide attempt AE that has suicide attempt or gesture without intent to die which may not require hospitalization CTCAE: E12970 Grade 4 suicide attempt AE a suicide attempt AE that has suicide attempt with intent to die which requires hospitalization YH, MW CTCAE: E12971 Grade 3 aphonia AE CTCAE: E12590 YH, MW an aphonia AE that has voicelessness; unable to speak Grade 1 depressed level of consciousness AE CTCAE: E12626 a depressed level of consciousness AE that has decreased level of alertness YH, MW Grade 2 depressed level of consciousness AE CTCAE: E12627 YH, MW a depressed level of consciousness AE that has Sedation; slow response to stimuli; limiting instrumental ADL Grade 3 depressed level of consciousness AE a depressed level of consciousness AE that is difficult to arouse YH, MW CTCAE: E12628 Grade 1 dysgeusia AE YH, MW a dysgenusia AE that has altered taste but no change in diet CTCAE: E12644 Grade 2 dysgeusia AE YH, MW CTCAE: E12645 a dysgenusia AE that has altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste Grade 1 leukoencephalopathy AE CTCAE: E12713 YH, MW a leukoencephalopathy AE that has asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly Grade 2 leukoencephalopathy AE YH, MW CTCAE: E12714 a leukoencephalopathy AE that has moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly Grade 3 leukoencephalopathy AE CTCAE: E12715 YH, MW a leukoencephalopathy AE that has severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly Grade 4 leukoencephalopathy AE a leukoencephalopathy AE that has life-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly YH, MW CTCAE: E12716 Grade 1 myelitis AE CTCAE: E12733 a myelitis AE that has asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign) YH, MW Grade 2 myelitis AE YH, MW a myelitis AE that has moderate weakness or sensory loss; limiting instrumental ADL CTCAE: E12734 Grade 3 myelitis AE CTCAE: E12735 YH, MW a myelitis AE that has severe weakness or sensory loss; limiting self care ADL Grade 2 presyncope AE CTCAE: E12779 YH, MW a presyncope AE that has present (e.g., near fainting) Grade 1 seizure AE YH, MW a seizure AE that has brief partial seizure; no loss of consciousness CTCAE: E12805 Grade 2 seizure AE a seizure AE that has brief generalized seizure CTCAE: E12806 YH, MW Grade 3 seizure AE CTCAE: E12807 a seizure AE that has multiple seizures despite medical intervention YH, MW Grade 4 seizure AE CTCAE: E12808 a seizure AE that has life-threatening; prolonged repetitive seizures YH, MW Grade 1 somnolence AE CTCAE: E12815 YH, MW a somnolence AE that has mild but more than usual drowsiness or sleepiness Grade 2 somnolence AE CTCAE: E12816 YH, MW a somnolence AE that has moderate sedation; limiting instrumental ADL Grade 3 somnolence AE YH, MW a somnolence AE that has obtundation or stupor CTCAE: E12817 Grade 3 syncope AE a syncope AE that has fainting; orthostatic collapse CTCAE: E12833 YH, MW Grade 1 arthritis AE CTCAE: E12379 YH, MW an arthritis AE that has mild pain with inflammation, erythema, or joint swelling Grade 2 arthritis AE an arthritis AE that has moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL CTCAE: E12380 YH, MW Grade 3 arthritis AE YH, MW an arthritis AE that has severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; disabling; limiting self care ADL CTCAE: E12381 Grade 1 joint range of motion decreased AE YH, MW a joint range of motion decreased AE that requires <=25% loss of ROM (range of motion); decreased ROM limiting athletic activity CTCAE: E12436 Grade 2 joint range of motion decreased AE CTCAE: E12437 a joint range of motion decreased AE that requires >25 - 50% decrease in ROM; limiting instrumental ADL YH, MW Grade 3 joint range of motion decreased AE a joint range of motion decreased AE that requires >50% decrease in ROM; limiting self care ADL; disabling CTCAE: E12438 YH, MW Grade 1 osteoporosis AE YH, MW CTCAE: E12509 an osteoporosis AE that has radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); no loss of height or intervention indicated Grade 2 osteoporosis AE YH, MW an osteoporosis AE that has BMD t-score <-2.5; loss of height <2 cm; anti-osteoporotic therapy indicated; limiting instrumental ADL CTCAE: E12510 Grade 3 osteoporosis AE CTCAE: E12511 an osteoporosis AE that has loss of height >=2 cm; hospitalization indicated; limiting self care ADL YH, MW Grade 1 acidosis AE YH, MW CTCAE: E12238 an acidosis AE that has pH <normal, but >=7.3 Grade 3 acidosis AE an acidosis AE that has pH <7.3 CTCAE: E12239 YH, MW Grade 1 anorexia AE an anorexia AE that has loss of appetite without alteration in eating habits YH, MW CTCAE: E12253 Grade 2 anorexia AE CTCAE: E12254 an anorexia AE that has oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated YH, MW Grade 3 anorexia AE YH, MW CTCAE: E12255 an anorexia AE that has associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated Grade 1 dehydration AE YH, MW CTCAE: E12259 a dehydration AE that has increased oral fluids indicated; dry mucous membranes; diminished skin turgor Grade 2 dehydration AE YH, MW a dehydration AE that requires IIV fluids indicated <24 hrs CTCAE: E12260 Grade 1 hypercalcemia AE a hypercalcemia AE that has corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L CTCAE: E12271 YH, MW Grade 2 hypercalcemia AE a hypercalcemia AE that has corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic YH, MW CTCAE: E12272 Grade 3 hypercalcemia AE CTCAE: E12273 YH, MW a hypercalcemia AE that has corrected serum calcium of >12.5 - 13.5 mg/dL; >3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated Grade 4 hypercalcemia AE a hypercalcemia AE that has corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences CTCAE: E12274 YH, MW Grade 1 hyperglycemia AE YH, MW CTCAE: E12277 a hypeglycemia AE that has fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L Grade 2 hyperglycemia AE CTCAE: E12278 a hypeglycemia AE that has fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L YH, MW Grade 3 hyperglycemia AE YH, MW a hypeglycemia AE that has >250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated CTCAE: E12279 Grade 4 hyperglycemia AE CTCAE: E12280 a hypeglycemia AE that has >500 mg/dL; >27.8 mmol/L; life-threatening consequences YH, MW Grade 1 hyperkalemia AE CTCAE: E12283 YH, MW a hyperkalemia AE that requires >ULN - 5.5 mmol/L Grade 2 hyperkalemia AE a hyperkalemia AE that requires >5.5 - 6.0 mmol/L YH, MW CTCAE: E12284 Grade 3 hyperkalemia AE CTCAE: E12285 YH, MW a hyperkalemia AE that requires >6.0 - 7.0 mmol/L; hospitalization indicated Grade 4 hyperkalemia AE YH, MW CTCAE: E12286 a hyperkalemia AE that requires >7.0 mmol/L; life-threatening consequences Grade 1 hypertriglyceridemia AE a hypertriglyceridemia AE that requires 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L YH, MW CTCAE: E12300 Grade 2 hypertriglyceridemia AE a hypertriglyceridemia AE that requires >300 mg/dL - 500 mg/dL; >3.42 mmol/L - 5.7 mmol/L YH, MW CTCAE: E12301 Grade 3 hypertriglyceridemia AE CTCAE: E12302 a hypertriglyceridemia AE that requires >500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L YH, MW Grade 4 hypertriglyceridemia AE a hypertriglyceridemia AE that requires >1000 mg/dL; >11.4 mmol/L; life-threatening consequences YH, MW CTCAE: E12303 Grade 1 hyperuricemia AE CTCAE: E12306 a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) without physiologic consequences YH, MW Grade 3 hyperuricemia AE CTCAE: E12307 a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) with physiologic consequences YH, MW Grade 4 hyperuricemia AE CTCAE: E12308 a hyperuricemia AE that requires >10 mg/dL; >0.59 mmol/L; life-threatening consequences YH, MW Grade 1 hypoalbuminemia AE a hypoalbuminemia AE that requires NCI<LLN - 3 g/dL; <LLN - 30 g/L CTCAE: E12311 YH, MW Grade 2 hypoalbuminemia AE YH, MW a hypoalbuminemia AE that requires NCI<3 - 2 g/dL; <30 - 20 g/L CTCAE: E12312 Grade 3 hypoalbuminemia AE a hypoalbuminemia AE that requires NCI<2 g/dL; <20 g/L CTCAE: E12313 YH, MW Grade 1 hypocalcemia AE YH, MW CTCAE: E12317 a hypocalcemia AE that requires corrected serum calcium of <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium <LLN - 1.0 mmol/L Grade 2 hypocalcemia AE YH, MW CTCAE: E12318 a hypocalcemia AE that requires corrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium <1.0 - 0.9 mmol/L; symptomatic Grade 3 hypocalcemia AE CTCAE: E12319 a hypocalcemia AE that requires corrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L; Ionized calcium <0.9 - 0.8 mmol/L; hospitalization indicated YH, MW Grade 4 hypocalcemia AE CTCAE: E12320 a hypocalcemia AE that requires corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences YH, MW Grade 1 hypoglycemia AE CTCAE: E12323 YH, MW a hypoglycernia AE that requires <LLN - 55 mg/dL; <LLN - 3.0 mmol/L Grade 2 hypoglycemia AE a hypoglycernia AE that requires <55 - 40 mg/dL; <3.0 - 2.2 mmol/L CTCAE: E13874 YH, MW Grade 3 hypoglycemia AE a hypoglycernia AE that requires <40 - 30 mg/dL; <2.2 - 1.7 mmol/L YH, MW CTCAE: E12324 Grade 4 hypoglycemia AE a hypoglycernia AE that requires <30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures CTCAE: E12325 YH, MW Grade 1 hypomagnesemia AE CTCAE: E12334 YH, MW a hypomagnesemia AE that requires <LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L Grade 2 hypomagnesemia AE YH, MW a hypomagnesemia AE that requires <1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L CTCAE: E12335 Grade 3 hypomagnesemia AE CTCAE: E12336 YH, MW a hypomagnesemia AE that requires <0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L Grade 4 hypomagnesemia AE a hypomagnesemia AE that requires <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences YH, MW CTCAE: E12337 Grade 1 hypophosphatemia AE CTCAE: E12345 a hypophosphatemia AE that requires <LLN - 2.5 mg/dL; <LLN - 0.8 mmol/L YH, MW Grade 2 hypophosphatemia AE a hypophosphatemia AE that requires <2.5 - 2.0 mg/dL; <0.8 - 0.6 mmol/L YH, MW CTCAE: E12346 Grade 3 hypophosphatemia AE a hypophosphatemia AE that requires <2.0 - 1.0 mg/dL; <0.6 - 0.3 mmol/L YH, MW CTCAE: E12347 Grade 4 hypophosphatemia AE CTCAE: E12348 YH, MW a hypophosphatemia AE that requires <1.0 mg/dL; <0.3 mmol/L; life-threatening consequences behavior abnormal quality YH, JX a behavioral quality where the behavior in an organism is abnormal. WEB: https://en.wikipedia.org/wiki/Abnormality_(behavior) cough increased AE 10011228 WEB: http://medical-dictionary.thefreedictionary.com/cough a cough AE that shows an increased rate of coughing YH, JX herpes viral infection AE 10019972 a viral infection AE that is caused by a herpes virus. Note that there are 8 herpesvirus types. WEB: https://en.wikipedia.org/wiki/Herpesviridae YH, JX chickenpox AE YH, JX WEB: https://en.wikipedia.org/wiki/Varicella_zoster_virus a herpez zoster AE that occurs in children. abnormal reflex AE 10038254 a nervous system AE that shows abnormal neurologic reflexes, which can be tesetd by the knee jerk reaction. JX, YH WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423 hyporeflexia AE 10021089 WEB: http://en.wikipedia.org/wiki/Hyporeflexia HPO: HP_0009072 SS, JX, YH an abnormal reflex AE where the patient has a condition of below normal or absent reflexes (areflexia). Hyporeflexia is the condition of below normal or absent reflexes. Hyporeflexia is generally associated with a lower motor neuron deficit (at the alpha motor neurons from the spinal cord to muscle). WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423 SIDER: C0151888 reflexes decreased AE hyperreflexia AE 10020745 WEB: https://en.wikipedia.org/wiki/Hyperreflexia SIDER: C0151889 HPO: HP_0001347 JX, YH an abnormal reflex AE that has an outcome of overactive reflexes, indicative of upper motor neuron disease as well as lessening or loss of control ordinarily exerted by higher brain centers of lower neural pathways. asystole AE 10003586 a cardiac arrest AE where there is no discernible electrical activity on the ECG monitor. YH, MW NCit:C50479 CTCAE: E10077 asystole WEB: http://www.cardiachealth.org/asystole-and-pulseless-electrical-activity Asystole is the absence of electrical activity in the heart, as evidenced by a flat line on an EKG. Cardiac arrest is a more general term for conditions where the heart is not circulating blood. Ventricular fibrillation (V-fib) or pulseless Ventricular tachycardia (V-tach) are examples of EKG rhythms which also will produce cardiac arrest, but are not asystole. Pulseless electrical activity (PEA) is another catch-all where there is an otherwise survivable EKG, but no blood is circulating. This can be caused by trauma to the heart, or tremendous blood loss, among other reasons. See: https://answers.yahoo.com/question/index?qid=20081027100243AAy0yt4 keratitis AE 10023332 WEB: http://www.mayoclinic.org/diseases-conditions/keratitis/basics/definition/con-20035288 MW, YH NCIT: C26805 CTCAE: E10397 an eye inflammation AE that occurs at the corneal area. eye infection AE 10015929 CTCAE: E11391 MW, YH WEB: https://www.nlm.nih.gov/medlineplus/eyeinfections.html an infection AE where one or two eyes get infected by bacteria, fungi, or viruses. NCIT: C45372 appendicitis AE 10003011 CTCAE: E11292 MW, YH an inflammation AE that shows inflammation at the location of appendix. NCIt: C35145 electrocardiogram QT corrected interval prolonged AE 10014383 WEB: http://lifeinthefastlane.com/ecg-library/basics/qt_interval/ NCIt: C71034 MW, YH CTCAE: E12146 UMLS: C0855333 an electrocardiogram QT prolonged AE that estimates the QT interval at a heart rate of 60 bpm. coordination and balance disorder AE 10072984 YH, QL coordination and balance disturbance AE a cross product of coordination abnormal AE and balance disorder AE aversion to greasy food AE an anorexia AE that has loss of appetite of greasy food. QL, YH WEB: http://www.anxietycare.org.uk/docs/eating.asp dysstasia AE 10050218 YH, QL a coordination and balance disorder AE that has difficulty in standing WEB: http://medical-dictionary.thefreedictionary.com/dysstasia dystasia AE dermatitis radiation AE 10061103 a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation CTCAE: E11675 NCIt: C0034561 WEB: http://www.dermnetnz.org/reactions/radiation-dermatitis.html MW, YH gastrorrhexis AE QL, YH WEB: http://medical-dictionary.thefreedictionary.com/gastrorrhexis a gastric disorder AE that shows an rupture in the stomach stomach rupture rupture AE WEB: https://en.wikipedia.org/wiki/Rupture YH. QL an injury AE that refers to break or burst suddenly (esp. of a pipe, a vessel, or a bodily part such as an organ or membrane) radiation burn AE 10063640 MW, YH WEB: https://en.wikipedia.org/wiki/Radiation_burn a radiation skin injury AE that shows skin burn from exposure to a large external dose of radiation cardiac troponin I increased AE 10007612 a troponin AE which indicates increased levels of cardiac troponin I in a biological specimen MW, YH CTCAE: E12116 NCIt: C78230 growth accelerated AE 10018746 CTCAE: E10317 MW, YH NCIt: C83495 a musculoskeletal or connective tissue AE that has greater growth than expected for age. postoperative thoracic procedure complication AE 10056745 a surgery AE that has the finding of a previously undocumented problem that occurs after a thoracic procedure. CTCAE: E11909 NCIt: C78567 MW, YH uterine perforation AE 10046810 MW, YH CTCAE: E12028 a uterine AE that has a rupture in the uterine wall. NCIt: C50793 fallopian tube perforation AE 10065790 MW, YH a female reproductive system AE that has the finding of rupture of the fallopian tube wall. CTCAE: E11697 NCIt: C78294 adrenal insufficiency AE 10001367 MW, YH NCIt: C26691 CTCAE: E10298 an endocrine system AE that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency. cushingoid AE 10011655 CTCAE: E10304 MW, YH NCIt: C37938 an endocrine system AE that has signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids. delayed puberty AE 10012205 NCIt: C62587 an endocrine system AE that has unusually late sexual maturity. CTCAE: E10308 MW, YH hyperparathyroidism AE 10020705 an endocrine system AE that has an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood). CTCAE: E10319 NCIt: C48259 MW, YH hypoparathyroidism AE 10021041 NCIt: C78350 an endocrine system AE that has a decrease in production of parathyroid hormone by the parathyroid glands. CTCAE: E10328 MW, YH virilization AE 10047488 MW, YH an endocrine system AE that has inappropriate masculinization occurring in a female or prepubertal male. CTCAE: E10343 NCIt: C79859 precocious puberty AE 10058084 CTCAE: E10340 NCIt: C79704 an endocrine system AE that has unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys. MW, YH seroma AE 10040102 NCIt: C50739 MW, YH CTCAE: E11938 a medical intervention site AE that has the finding of tumor-like collection of serum in the tissues. stomal ulcer AE 10042127 a medical intervention site AE that has a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure. NCIt: C79766 CTCAE: E11965 MW, YH intestinal stoma site bleeding AE 10049468 MW, YH CTCAE: E11764 a medical intervention site AE that has a finding of blood leakage from the intestinal stoma. NCIt: C78371 pancreatic anastomotic leak AE 10050457 NCIt: C78518 CTCAE: E11891 a medical intervention site AE that has the finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures). MW, YH biliary anastomotic leak AE 10050458 CTCAE: E11654 MW, YH NCIt: C78183 a medical intervention site AE that has the finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures). intestinal stoma leak AE 10059094 CTCAE: E11759 a medical intervention site AE that has the finding of blockage of the normal flow of the contents of the intestinal stoma. MW, YH NCIt: C78370 intestinal stoma leak AE 10059095 CTCAE: E11753 a medical intervention site AE that has the finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body). MW, YH NCIt: C78369 vascular access complication AE 10062169 a medical intervention site AE that has the finding of a previously undocumented problem related to the vascular access site. MW, YH CTCAE: E12046 NCIt: C78709 pharyngeal anastomotic leak AE 10065705 NCIt: C78550 CTCAE: E11897 a medical intervention site AE that has the finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures). MW, YH prolapse of intestinal stoma AE 10065745 CTCAE: E11914 MW, YH NCIt: C78570 a medical intervention site AE that has the finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface. urostomy site bleeding AE 10065748 NCIt: C78682 CTCAE: E12011 MW, YH a medical intervention site AE that has the finding of bleeding from the urostomy site. tracheostomy site bleeding AE 10065749 MW, YH CTCAE: E11981 a medical intervention site AE that has the finding of blood leakage from the tracheostomy site. NCIt: C78648 fallopian tube anastomotic leak AE 10065788 a medical intervention site AE that has the finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures). NCIt: C78292 CTCAE: E11691 MW, YH bladder anastomotic leak AE 10065802 MW, YH CTCAE: E11660 a medical intervention site AE that has the finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures). NCIt: C78206 kidney anastomotic leak AE 10065803 NCIt: C78406 CTCAE: E11879 MW, YH a medical intervention site AE that has the finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures). ureteric anastomotic leak AE 10065814 MW, YH NCIt: C78662 CTCAE: E11987 a medical intervention site AE that has the finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures). urethral anastomotic leak 10065815 a medical intervention site AE that has the finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures). MW, YH NCIt: C78667 CTCAE: E11993 prolapse of urostomy AE 10065822 NCIt: C78571 CTCAE: E11920 a medical intervention site AE that has the finding of displacement of the urostomay MW, YH gastrointestinal anastomotic leak 10065879 CTCAE: E11715 NCIt: C78318 a medical intervention site AE that has the finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures). MW, YH urostomy leak AE 10065882 CTCAE: E11999 NCIt: C78679 MW, YH a medical intervention site AE that has the finding of leakage of contents from a urostomy. urostomy obstruction AE 10065883 MW, YH CTCAE: E12005 NCIt: C78680 a medical intervention site AE that has the finding of blockage of the urostomy. urostomy stenosis AE 10065885 NCIt: C78683 a medical intervention site AE that has the finding of narrowing of the opening of a urostomy. CTCAE: E12017 MW, YH uterine anastomotic leak AE 10065886 MW, YH NCIt: C78684 CTCAE: E12022 a medical intervention site AE that has the finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures). vaginal anastomotic leak AE 10065887 CTCAE: E12034 MW, YH a medical intervention site AE that has the finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures). NCIt: C78698 vas deferens anastomotic leak AE 10065888 MW, YH a medical intervention site AE that has the finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures). NCIt: C78704 CTCAE: E12040 large intestinal anastomotic leak AE 10065891 NCIt: C78408 MW, YH a medical intervention site AE that has the finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine. CTCAE: E11885 small intestinal anastomotic leak AE 10065892 MW, YH CTCAE: E11942 a medical intervention site AE that has the finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel. NCIt: C78612 gastric anastomotic leak AE 10065893 MW, YH a medical intervention site AE that has the finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures). CTCAE: E11709 NCIt: C78310 rectal anastomotic leak AE 10065894 MW, YH CTCAE: E11932 NCIt: C78583 a medical intervention site AE that has the finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures). spermatic cord anastomotic leak AE 10065897 NCIt: C78622 CTCAE: E11948 MW, YH a medical intervention site AE that has the finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures). stenosis of gastrointestinal stoma AE 10065898 NCIt: C78628 CTCAE: E11960 MW, YH a medical intervention site AE that has the finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body). esophageal anastomotic leak AE 10065961 MW, YH CTCAE: E11681 NCIt: C78270 a medical intervention site AE that has the finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures). bladder infection AE 10005047 NCIt: C26738 MW, YH an infection AE that has an infectious process involving the bladder. CTCAE: E11309 cervicitis infection AE 10008330 MW, YH CTCAE: E11337 an infection AE that has an infectious process involving the uterine cervix. NCIt: C78360 encephalitis infection AE 10014594 NCIt: C79550 CTCAE: E11365 an infection AE that has an infectious process involving the brain tissue. MW, YH encephalomyelitis infection AE 10014621 NCIt: C79551 MW, YH CTCAE: E11369 an infection AE that has an infectious process involving the brain and spinal cord tissues. endocarditis infective AE 10014678 CTCAE: E11373 an infection AE that has an infectious process involving the endocardial layer of the heart. MW, YH NCIt: C78265 gum infection AE 10018784 MW, YH CTCAE: E11400 NCIt: C78329 an infection AE that has an infectious process involving the gums. infective myositis AE 10021918 NCIt: C26984 MW, YH an infection AE that has an infectious process involving the skeletal muscles. CTCAE: E11421 joint infection AE 10023216 an infection AE that has an infectious process involving a joint. MW, YH NCIt: C78402 CTCAE: E11426 kidney infection AE 10023424 MW, YH NCIt: C34965 an infection AE that has an infectious process involving the kidney. CTCAE: E11431 otitis externa AE 10033072 an infection AE that has an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage. NCIt: C3299 CTCAE: E11472 MW, YH salivary gland infection AE 10039413 NCIt: C78601 MW, YH an infection AE that has an infectious process involving the salivary gland. CTCAE: E11550 wound infection AE 10048038 an infection AE that has an infectious process involving the wound. MW, YH CTCAE: E11635 NCIt: C45234 tooth infection AE 10048762 an infection AE that has an infectious process involving a tooth. MW, YH NCIt: C78639 CTCAE: E11594 prostate infection AE 10050662 MW, YH NCIt: C27615 an infection AE that has an infectious process involving the prostate gland. CTCAE: E11540 lymph gland infection AE 10050823 NCIt: C26821 an infection AE that has an infectious process involving the lymph nodes. MW, YH CTCAE: E11449 pancreas infection AE 10051741 MW, YH CTCAE: E11487 an infection AE that has an infectious process involving the pancreas. NCIt: C78517 urethral infection AE 10052298 MW, YH NCIt: C78671 CTCAE: E11609 an infection AE that has an infectious process involving the urethra. ovarian infection AE 10055005 NCIt: C78512 CTCAE: E11482 MW, YH an infection AE that has an infectious process involving the ovary. abdominal infection AE 10056519 an infection AE that has an infectious process involving the abdominal cavity. CTCAE: E11282 NCIt: C35669 MW, YH hepatic infection AE 10056522 NCIt: C78339 an infection AE that has an infectious process involving the liver. MW, YH CTCAE: E11406 phlebitis infective AE 10056627 CTCAE: E11530 NCIt: C78558 an infection AE that has an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein. MW, YH peritoneal infection AE 10057262 MW, YH CTCAE: E11521 an infection AE that has an infectious process involving the peritoneum. NCIt: C78540 mediastinal infection AE 10057483 an infection AE that has an infectious process involving the mediastinum. MW, YH CTCAE: E11454 NCIt: C26827 pelvic infection AE 10058674 an infection AE that has an infectious process involving the pelvic cavity. MW, YH NCIt: C3889 CTCAE: E11501 esophageal infection AE 10058804 an infection AE that has an infectious process involving the esophagus. CTCAE: E11386 MW, YH NCIt: C78277 enterocolitis infectious AE 10058838 MW, YH CTCAE: E11381 an infection AE that has an infectious process involving the small and large intestines. NCIt: C80513 rhinitis infective AE 10059827 CTCAE: E11548 NCIt: C78599 MW, YH an infection AE that has an infectious process involving the nasal mucosal. bone infection AE 10061017 NCIt: C26839 MW, YH CTCAE: E11314 an infection AE that has an infectious process involving the bones. pleural infection AE 10061351 CTCAE: E11535 MW, YH an infection AE that has an infectious process involving the pleura. NCIt: C78563 anorectal infection AE 10061640 CTCAE: E11286 NCIt: C78174 MW, YH an infection AE that has an infectious process involving the anal area and the rectum. biliary tract infection AE 10061695 CTCAE: E11305 MW, YH NCIt: C26718 an infection AE that has an infectious process involving the biliary tract. penile infection AE 10061912 an infection AE that has an infectious process involving the penis. NCIt: C78526 MW, YH CTCAE: E11506 splenic infection AE 10062112 MW, YH an infection AE that has an infectious process involving the spleen. CTCAE: E11584 NCIt: C78627 scrotal infection AE 10062156 NCIt: C78606 CTCAE: E11555 an infection AE that has an infectious process involving the scrotum. MW, YH uterine infection AE 10062233 MW, YH NCIt: C26764 an infection AE that has an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues. CTCAE: E11619 gallbladder infection AE 10062632 NCIt: C78306 an infection AE that has an infectious process involving the gallbladder. CTCAE: E11396 MW, YH stoma site infection AE 10064505 an infection AE that has an infectious process involving a stoma (surgically created opening on the surface of the body). CTCAE: E11588 MW, YH NCIt: C78629 arteritis infective AE 10065744 NCIt: C34399 CTCAE: E11301 MW, YH an infection AE that has an infectious process involving an artery. duodenal infection AE 10065752 MW, YH an infection AE that has an infectious process involving the duodenum. NCIt: C78258 CTCAE: E11360 lip infection AE 10065755 MW, YH NCIt: C78434 an infection AE that has an infectious process involving the lips. CTCAE: E11440 cecal infection AE 10065761 an infection AE that has an infectious process involving the cecum. CTCAE: E11333 MW, YH NCIt: C78235 mucosal infection AE 10065764 MW, YH NCIt: C78454 an infection AE that has an infectious process involving a mucosal surface. CTCAE: E11462 cranial nerve infection AE 10065765 an infection AE that has an infectious process involving a cranial nerve. CTCAE: E11352 NCIt: C78248 MW, YH peripheral nerve infection AE 10065766 CTCAE: E11516 an infection AE that has an infectious process involving the peripheral nerves. MW, YH NCIt: C27589 small intestine infection AE 10065771 NCIt: C78618 CTCAE: E11574 MW, YH an infection AE that has an infectious process involving the small intestine. vulval infection AE 10065772 MW, YH NCIt: C78716 an infection AE that has an infectious process involving the vulva. CTCAE: E11629 anal pain AE 10002167 NCIt: C78172 CTCAE: E10486 a pain AE that has a sensation of marked discomfort in the anal region. MW, YH gallbladder pain AE 10017638 a pain AE that has a sensation of marked discomfort in the gallbladder region. CTCAE: E11204 MW, YH NCIt: C78304 gastrointestinal pain AE 10017999 MW, YH CTCAE: E10755 a pain AE that has a sensation of marked discomfort in the gastrointestinal region. NCIt: C78320 hepatic pain AE 10019705 MW, YH CTCAE: E11224 NCIt: C78341 a pain AE that has a sensation of marked discomfort in the liver region. lip pain AE 10024561 MW, YH CTCAE: E10857 NCIt: C79684 a pain AE that has a sensation of marked discomfort of the lip. rectal pain AE 10038072 a pain AE that has a sensation of marked discomfort in the rectal region. MW, YH NCIt: C78587 CTCAE: E10977 stomach pain AE 10042112 MW, YH NCIt: C78630 a pain AE that has a sensation of marked discomfort in the stomach. CTCAE: E11044 non-cardiac chest pain AE 10062501 CTCAE: E11163 NCIt: C78504 a chest pain AE that has discomfort in the chest unrelated to a heart disorder. MW, YH tracheal obstruction AE 10044291 NCIt: C78645 CTCAE: E11975 MW, YH a respiratory system AE that has the finding of blockage of the lumen of the trachea. colonic hemorrhage AE 10009998 NCIt: C78240 a hemorrhage AE that has bleeding from the colon. CTCAE: E10533 MW, YH esophageal hemorrhage AE 10015384 MW, YH a hemorrhage AE that has bleeding from the esophagus. CTCAE: E10645 NCIt: C78271 esophageal varices hemorrhage AE 10015453 a hemorrhage AE that has bleeding from esophageal varices. NCIt: C78282 CTCAE: E10682 MW, YH hepatic hemorrhage AE 10019678 CTCAE: E11215 MW, YH NCIt: C78338 a hemorrhage AE that has bleeding from the liver. oral hemorrhage AE 10030980 NCIt: C79699 MW, YH CTCAE: E10898 a hemorrhage AE that has bleeding from the mouth. pancreatic hemorrhage AE 10033626 NCIt: C78521 MW, YH CTCAE: E10920 a hemorrhage AE that has bleeding from the pancreas. retroperitoneal hemorrhage AE 10038981 MW, YH CTCAE: E10998 a hemorrhage AE that has bleeding from the retroperitoneal area. NCIt: C26944 lower gastrointestinal hemorrhage AE 10051746 a hemorrhage AE that has bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus). CTCAE: E10861 MW, YH NCIt: C78438 duodenal hemorrhage AE 10055242 CTCAE: E10588 NCIt: C78257 MW, YH a hemorrhage AE that has bleeding from the duodenum. ileal hemorrhage AE 10055287 CTCAE: E10783 MW, YH NCIt: C78353 a hemorrhage AE that has bleeding from the ileal wall. intra-abdominal hemorrhage AE 10055291 a hemorrhage AE that has bleeding in the abdominal cavity. MW, YH NCIt: C78372 CTCAE: E10817 jejunal hemorrhage AE 10055300 CTCAE: E10828 NCIt: C78397 MW, YH a hemorrhage AE that has bleeding from the jejunal wall. postoperative hemorrhage AE 10055322 NCIt: C34938 a hemorrhage AE that has the finding of bleeding occurring after a surgical procedure. MW, YH CTCAE: E11903 tracheal hemorrhage AE 10062548 CTCAE: E11969 a hemorrhage AE that has the finding of bleeding from the trachea. MW, YH NCIt: C78642 cecal hemorrhage AE 10065747 MW, YH CTCAE: E10511 a hemorrhage AE that has bleeding from the cecum. NCIt: C78234 anal stenosis AE 10002176 CTCAE: E10490 an anus AE that has a narrowing of the lumen of the anal canal. NCIt: C78173 MW, YH biliary fistula AE 10004665 NCIt: C79540 CTCAE: E11179 MW, YH a digestive system AE that has an abnormal communication between the bile ducts and another organ or anatomic site. bloating AE 10005265 MW, YH NCIt: C78213 CTCAE: E10508 a digestive system AE that has subject-reported feeling of uncomfortable fullness of the abdomen. colonic fistula AE 10009995 a digestive system AE that has an abnormal communication between the large intestine and another organ or anatomic site. MW, YH CTCAE: E10527 NCIt: C78239 colonic obstruction AE 10010000 MW, YH a digestive system AE that has blockage of the normal flow of the intestinal contents in the colon. CTCAE: E10539 NCIt: C78241 colonic perforation AE 10010001 a digestive system AE that has a rupture in the colonic wall. NCIt: C78242 MW, YH CTCAE: E10545 colonic ulcer AE 10010006 CTCAE: E10556 MW, YH a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon. NCIt: C78244 duodenal fistula AE 10013828 CTCAE: E10582 MW, YH a duodenum AE that has an abnormal communication between the duodenum and another organ or anatomic site. NCIt: C78256 duodenal obstruction AE 10013830 MW, YH NCIt: C79548 a duodenum AE that has blockage of the normal flow of stomach contents through the duodenum. CTCAE: E10594 duodenal perforation AE 10013832 MW, YH NCIt: C78259 CTCAE: E10600 a duodenum AE that has a rupture in the duodenal wall. esophageal obstruction AE 10015387 an esophagus AE that has blockage of the normal flow of the contents in the esophagus. CTCAE: E10655 MW, YH NCIt: C78279 esophageal ulcer AE 10015451 NCIt: C26950 an esophagus AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall. CTCAE: E10676 MW, YH gallbladder fistula AE 10017631 a digestive system AE that has an abnormal communication between the gallbladder and another organ or anatomic site. MW, YH NCIt: C78305 CTCAE: E11189 gallbladder obstruction AE 10017636 MW, YH a digestive system AE that has blockage of the normal flow of the contents of the gallbladder. NCIt: C78308 CTCAE: E11198 gastric perforation AE 10017815 a gastrointestinal perforation AE that occurs in the stomach wall. MW, YH NCIt: C78316 CTCAE: E10716 gastrointestinal fistula AE 10017877 MW, YH CTCAE: E10749 NCIt: C78319 a gastrointestinal disoder AE that has an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site. gastroparesis AE 10018043 CTCAE: E10759 NCIt: C80512 a gastric AE that has an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine. MW, YH ileal stenosis AE 10021307 MW, YH NCIt: C78356 a digestive system AE that has a narrowing of the lumen of the ileum. CTCAE: E10800 ileal ulcer AE 10021309 a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum. NCIt: C78357 MW, YH CTCAE: E10806 jejunal perforation AE 10023174 NCIt: C78399 MW, YH a digestive system AE that has a rupture in the jejunal wall. CTCAE: E10840 jejunal stenosis AE 10023176 CTCAE: E10845 a digestive system AE that has a narrowing of the lumen of the jejunum. MW, YH NCIt: C78400 jejunal ulcer AE 10023177 MW, YH a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum. NCIt: C78401 CTCAE: E10851 malabsorption AE 10025476 NCIt: C3214 a digestive system AE that has inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea. MW, YH CTCAE: E10867 obstruction gastric AE 10029957 a digestive system AE that has blockage of the normal flow of the contents in the stomach. MW, YH NCIt: C78505 CTCAE: E10882 perforation bile duct AE 10034405 CTCAE: E11234 NCIt: C78528 a digestive system AE that has a rupture in the wall of the extrahepatic or intrahepatic bile duct. MW, YH rectal fistula AE 10038062 MW, YH a digestive system AE that has an abnormal communication between the rectum and another organ or anatomic site. NCIt: C79713 CTCAE: E10949 rectal perforation AE 10038073 MW, YH NCIt: C78588 CTCAE: E10981 a digestive system AE that has a rupture in the rectal wall. rectal stenosis AE 10038079 CTCAE: E10986 MW, YH a digestive system AE that has a narrowing of the lumen of the rectum. NCIt: C78589 rectal ulcer AE 10038080 CTCAE: E10992 a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum. NCIt: C78590 MW, YH salivary gland fistula AE 10039411 a digestive system AE that has an abnormal communication between a salivary gland and another organ or anatomic site. NCIt: C79715 CTCAE: E11009 MW, YH small intestinal perforation AE 10041103 a digestive system AE that has a rupture in the small intestine wall. NCIt: C78616 MW, YH CTCAE: E11027 pancreatic fistula AE 10049192 MW, YH CTCAE: E10914 a digestive system AE that has an abnormal communication between the pancreas and another organ or anatomic site. NCIt: C79701 duodenal stenosis AE 10050094 CTCAE: E10605 MW, YH NCIt: C78260 a duodenum AE that has a narrowing of the lumen of the duodenum. bile duct stenosis AE 10051341 MW, YH NCIt: C78182 a digestive system AE that has a narrowing of the lumen of the bile duct. CTCAE: E11173 gastric necrosis AE 10051886 CTCAE: E10712 NCIt: C78314 MW, YH a gastric disorder AE that has a necrotic process occurring in the gastric wall. pancreatic necrosis AE 10058096 NCIt: C78522 a digestive system AE that has a necrotic process occurring in the pancreas. CTCAE: E10926 MW, YH gallbladder necrosis AE 10059446 MW, YH a digestive system AE that has a necrotic process occurring in the gallbladder. NCIt: C78307 CTCAE: E11195 gastric stenosis AE 10061970 a gastric disorder AE that has a narrowing of the lumen of the stomach. CTCAE: E10721 MW, YH NCIt: C78317 enterovesical fistula AE 10062570 a digestive system AE that has an abnormal communication between the urinary bladder and the intestine. MW, YH NCIt: C78266 CTCAE: E10633 pancreatic duct stenosis AE 10065703 a digestive system AE that has a narrowing of the lumen of the pancreatic duct. MW, YH NCIt: C78519 CTCAE: E10908 peritoneal necrosis AE 10065704 a digestive system AE that has a necrotic process occurring in the peritoneum. CTCAE: E10939 MW, YH NCIt: C78543 rectal obstruction AE 10065707 CTCAE: E10971 NCIt: C78586 MW, YH a digestive system AE that has blockage of the normal flow of the intestinal contents in the rectum. gastrointestinal stoma necrosis 10065712 a gastrointestinal disoder AE that has the finding of a necrotic process occurring in the gastrointestinal tract stoma. MW, YH NCIt: C78321 CTCAE: E11721 gastric fistula AE 10065713 NCIt: C79595 CTCAE: E10700 MW, YH a gastric disorder AE that has an abnormal communication between the stomach and another organ or anatomic site. jejunal fistula AE 10065719 MW, YH CTCAE: E10822 a digestive system AE that has an abnormal communication between the jejunum and another organ or anatomic site. NCIt: C78396 anal necrosis AE 10065722 NCIt: C78171 CTCAE: E10482 an anus AE that has a necrotic process occurring in the anal region. MW, YH esophageal necrosis AE 10065727 MW, YH an esophagus AE that has a necrotic process occurring in the esophageal wall. CTCAE: E10651 NCIt: C78278 ileal fistula AE 10065728 NCIt: C78352 MW, YH CTCAE: E10777 a digestive system AE that has an abnormal communication between the ileum and another organ or anatomic site. ileal obstruction AE 10065730 MW, YH NCIt: C78354 CTCAE: E10789 a digestive system AE that has blockage of the normal flow of the intestinal contents in the ileum. jejunal obstruction AE 10065732 a digestive system AE that has blockage of the normal flow of the intestinal contents in the jejunum. NCIt: C78398 MW, YH CTCAE: E10834 esophageal fistula AE 10065851 NCIt: C79574 MW, YH CTCAE: E10639 an esophagus AE that has an abnormal communication between the esophagus and another organ or anatomic site. dry eye AE 10013774 NCIt: C34553 CTCAE: E10363 an eye AE that has dryness of the cornea and conjunctiva. MW, YH flashing lights AE 10016757 an eye AE that has a sudden or brief burst of light. MW, YH NCIt: C50568 CTCAE: E10384 floaters AE 10016778 an eye AE that has an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens. NCIt: C37955 CTCAE: E10388 MW, YH night blindness AE 10029404 CTCAE: E10401 MW, YH NCIt: C34850 an eye AE that has an inability to see clearly in dim light. retinal tear AE 10038897 MW, YH CTCAE: E10425 NCIt: C50732 an eye AE that has a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters. retinal vascular disorder AE 10038901 CTCAE: E10429 an eye AE that has pathological retinal blood vessels that adversely affects vision. NCIt: C35170 MW, YH vitreous hemorrhage AE 10047656 an eye AE that has blood extravasation into the vitreous humor. NCIt: C50469 CTCAE: E10447 MW, YH watering eyes AE 10047848 NCIt: C78717 MW, YH an eye AE that has excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct. CTCAE: E10452 optic nerve disorder AE 10061322 NCIt: C79698 an eye AE that has involvement of the optic nerve (second cranial nerve). CTCAE: E10406 MW, YH scleral disorder AE 10061510 CTCAE: E10437 NCIt: C79717 MW, YH an eye AE that has involvement of the sclera of the eye. vestibular disorder AE 10047386 CTCAE: E10295 NCIt: C27166 an ear AE that has dizziness, imbalance, nausea, and vision problems. MW, YH external ear pain AE 10065785 MW, YH an ear pain AE that has a sensation of marked discomfort in the external ear region. NCIt: C78285 CTCAE: E10272 constrictive pericarditis AE 10010783 CTCAE: E10120 NCIt: C78246 MW, YH a cardiovascular AE that has a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action. sick sinus syndrome AE 10040639 MW, YH NCIt: C62244 CTCAE: E10202 a cardiovascular AE that has a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness. pericardial tamponade AE 10053565 a cardiovascular AE that has an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium. NCIt: C50481 MW, YH CTCAE: E10177 tricuspid valve disease AE 10061389 MW, YH CTCAE: E10224 NCIt: C78649 a cardiovascular AE that has a defect in tricuspid valve function or structure. mitral valve disease AE 10061532 a cardiovascular AE that has a defect in mitral valve function or structure. NCIt: C78446 MW, YH CTCAE: E10134 pulmonary valve disease AE 10061541 a cardiovascular AE that has a defect in pulmonary valve function or structure. NCIt: C78579 CTCAE: E10186 MW, YH aortic valve disease AE 10061589 CTCAE: E10071 MW, YH NCIt: C78650 a cardiovascular AE that has a defect in aortic valve function or structure. tooth discoloration AE 10044031 CTCAE: E11052 a bone AE that has a change in tooth hue or tint. MW, YH NCIt: C80112 neck edema AE 10054482 MW, YH an edema AE that has swelling due to an accumulation of excessive fluid in the neck. CTCAE: E11159 NCIt: C78501 edema trunk AE 10058720 CTCAE: E11090 MW, YH NCIt: C78263 an edema AE that has swelling due to excessive fluid accumulation in the trunk area. proctitis AE 10036774 CTCAE: E10943 MW, YH NCIt: C38011 an inflammation AE that has inflammation of the rectum. rectal mucositis AE 10063190 NCIt: C78584 an inflammation AE that has inflammation of the mucous membrane of the rectum MW, YH CTCAE: E10961 anal mucositis AE 10065721 MW, YH CTCAE: E10476 NCIt: C78170 an inflammation AE that has inflammation of the mucous membrane of the anus. external ear inflammation AE 10065837 an inflammation AE that has inflammation, swelling and redness to the outer ear and ear canal. NCIt: C79601 MW, YH CTCAE: E10266 middle ear inflammation AE 10065838 MW, YH an inflammation AE that has inflammation (physiologic response to irritation), swelling and redness to the middle ear. NCIt: C34885 CTCAE: E10281 death neonatal AE 10011912 NCIt: C80082 MW, YH CTCAE: E11078 a death AE that has cessation of life occurring during the first 28 days of life. ankle fracture AE 10002544 NCIt: C26989 CTCAE: E11640 a fracture AE that has a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot. MW, YH hip fracture AE 10020100 CTCAE: E11726 a fracture AE that has the finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken. NCIt: C26794 MW, YH spinal fracture AE 10041569 NCIt: C80516 a fracture AE that has the finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken. MW, YH CTCAE: E11954 wrist fracture AE 10048049 a fracture AE that has the finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken. MW, YH CTCAE: E12069 NCIt: C80517 bronchial infection AE 10055078 a lung infection AE that has an infectious process involving the bronchi. NCIt: C2911 MW, YH CTCAE: E11323 CPK increased AE 10011268 MW, YH a muscle enzyme level increased AE that has the finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen. CTCAE: E12132 NCIt: C78247 radiation recall reaction (dermatologic) AE 10037767 CTCAE: E11926 MW, YH a recall phenomenon AE that has the finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent. NCIt: C78580 CD4 lymphocytes decreased AE 10007839 MW, YH NCIt: C78233 CTCAE: E12122 an immunology and allergy investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen. vital capacity abnormal AE 10047580 CTCAE: E12220 NCIt: C78715 a respiratory and pulmonary investigation result abnormal AE that has the finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value. MW, YH carbon monoxide diffusing capacity decreased AE 10065906 MW, YH CTCAE: E12112 a respiratory and pulmonary investigation result abnormal AE that has the finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide. NCIt: C78229 blood antidiuretic hormone abnormal AE 10005332 CTCAE: E12092 NCIt: C78214 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen. MW, YH blood corticotrophin decreased AE 10005452 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen. CTCAE: E12101 MW, YH NCIt: C78215 blood gonadotrophin abnormal AE 10005561 NCIt: C78216 MW, YH an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen. CTCAE: E12105 blood prolactin abnormal AE 10005778 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen. CTCAE: E12109 NCIt: C78217 MW, YH growth hormone abnormal AE 10018748 NCIt: C78327 an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen. MW, YH CTCAE: E12166 pancreatic enzymes decreased AE 10062646 MW, YH NCIt: C78520 CTCAE: E12203 an enzyme investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen. fibrinogen decreased AE 10016596 MW, YH NCIt: C78300 a hematology investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen. CTCAE: E12151 haptoglobin decreased AE 10019150 NCIt: C78330 a hematology investigation result abnormal with the finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen. CTCAE: E12169 MW, YH acute coronary syndrome AE 10051592 MW, YH NCIt: C53652 a coronary heart disease AE that has signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction. CTCAE: E10066 eyelid function disorder AE 10061145 CTCAE: E10380 MW, YH an eyelid disorder AE that has impaired eyelid function. NCIt: C78288 aortic injury AE 10002899 CTCAE: E11644 MW, YH NCIt: C35623 an injury AE that has the finding of damage to the aorta. arterial injury AE 10003162 an injury AE that has the finding of damage to an artery CTCAE: E11648 MW, YH NCIt: C35401 injury to carotid artery AE 10022161 CTCAE: E11730 MW, YH NCIt: C79599 an injury AE that has the finding of damage to the carotid artery. injury to inferior vena cava AE 10022213 MW, YH CTCAE: E11734 an injury AE that has the finding of damage to the inferior vena cava. NCIt: C78363 injury to superior vena cava AE 10022356 CTCAE: E11741 an injury AE that has the finding of damage to the superior vena cava. MW, YH NCIt: C78365 intraoperative gastrointestinal injury AE 10065825 MW, YH CTCAE: E11798 an injury AE that has the finding of damage to the gastrointestinal system during a surgical procedure. NCIt: C78380 intraoperative arterial injury AE 10065826 CTCAE: E11770 an injury AE that has the finding of damage to an artery during a surgical procedure. MW, YH NCIt: C78375 intraoperative hepatobiliary injury AE 10065827 an injury AE that has the finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure. CTCAE: E11814 MW, YH NCIt: C78382 intraoperative urinary injury AE 10065828 NCIt: C78391 CTCAE: E11867 MW, YH an injury AE that has the finding of damage to the urinary system during a surgical procedure. intraoperative musculoskeletal injury AE 10065829 MW, YH CTCAE: E11820 an injury AE that has the finding of damage to the musculoskeletal system during a surgical procedure. NCIt: C78383 intraoperative neurological injury AE 10065830 CTCAE: E11826 MW, YH an injury AE that has the finding of damage to the nervous system during a surgical procedure. NCIt: C78384 intraoperative breast injury AE 10065831 NCIt: C78376 MW, YH CTCAE: E11776 an injury AE that has the finding of damage to the breast parenchyma during a surgical procedure. intraoperative respiratory injury AE 10065832 CTCAE: E11850 NCIt: C78388 an injury AE that has the finding of damage to the respiratory system during a surgical procedure. MW, YH intraoperative endocrine injury AE 10065834 CTCAE: E11792 an injury AE that has the finding of damage to the endocrine gland during a surgical procedure. MW, YH NCIt: C78379 intraoperative reproductive tract injury AE 10065840 CTCAE: E11844 an injury AE that has the finding of damage to the reproductive organs during a surgical procedure. MW, YH NCIt: C78387 intraoperative ocular injury AE 10065841 NCIt: C78385 CTCAE: E11832 an injury AE that has the finding of damage to the eye during a surgical procedure. MW, YH lintraoperative head and neck injury AE 10065842 MW, YH CTCAE: E11804 NCIt: C78381 an injury AE that has the finding of damage to the head and neck during a surgical procedure. intraoperative cardiac injury AE 10065843 CTCAE: E11782 an injury AE that has the finding of damage to the heart during a surgical procedure. MW, YH NCIt: C78377 intraoperative ear injury AE 10065844 CTCAE: E11786 MW, YH NCIt: C78378 an injury AE that has the finding of damage to the ear during a surgical procedure. intraoperative renal injury AE 10065845 CTCAE: E11838 an injury AE that has the finding of damage to the kidney during a surgical procedure. NCIt: C78386 MW, YH intraoperative skin injury AE 10065846 MW, YH NCIt: C78389 an injury AE finding of damage to the skin during a surgical procedure. CTCAE: E11856 intraoperative splenic injury AE 10065847 NCIt: C78390 CTCAE: E11862 an injury AE that has the finding of damage to the spleen during a surgical procedure. MW, YH intraoperative venous injury AE 10065848 CTCAE: E11873 MW, YH an injury AE that has the finding of damage to a vein during a surgical procedure. NCIt: C78392 injury to jugular vein AE 10065849 an injury AE that has the finding of damage to the jugular vein. CTCAE: E11737 NCIt: C78364 MW, YH appendicitis perforated AE 10003012 NCIt: C78178 CTCAE: E11296 an appendicitis AE that has acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity. MW, YH cardiac troponin T increased 10007613 CTCAE: E12119 MW, YH NCIt: C78231 a troponin AE which indicates increased levels of cardiac troponin T in a biological specimen conjunctivitis infective AE 10010742 an eye infection AE that has an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes. CTCAE: E11342 MW, YH NCIt: C35704 endophthalmitis AE 10014801 an eye infection AE that has an infectious process involving the internal structures of the eye. NCIt: C34586 MW, YH CTCAE: E11377 periorbital infection AE 10051472 CTCAE: E11511 MW, YH an eye infection AE that has an infectious process involving the orbit of the eye. NCIt: C78531 corneal infection AE 10061788 MW, YH CTCAE: E11347 NCIt: C26805 an eye infection AE that has an infectious process involving the cornea. Grade 1 fatigue AE a fatigue AE that has fatigue relieved by rest CTCAE: E11099 MW, YH Grade 2 fatigue AE MW, YH a fatigue AE that has fatigue not relieved by rest; limiting instrumental activities of daily living CTCAE: E11100 Grade 3 fatigue AE a fatigue AE that has fatigue not relieved by rest, limiting self care activities of daily living CTCAE: E11101 MW, YH Grade 2 myocardial infarction AE MW, YH a myocardial infarction AE that has asymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes CTCAE: E10153 Grade 3 myocardial infarction AE a myocardial infarction AE that has severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction CTCAE: E10154 MW, YH Grade 3 pancreatitis AE a pancreatitis AE that has enzyme elevation or radiologic findings only CTCAE: E10931 MW, YH Grade 3 pancreatitis AE CTCAE: E10932 a pancreatitis AE that has severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support) MW, YH Grade 1 activated partial thromboplastin time prolonged AE an activated partial thromboplastin time prolonged AE that is greater than the upper limit of normal to 1.5 times the upper limit of normal CTCAE: E12074 MW, YH Grade 2 activated partial thromboplastin time prolonged AE an activated partial thromboplastin time prolonged AE that is 1.5-2.5 times the upper limit of normal MW, YH CTCAE: E12075 Grade 3 activated partial thromboplastin time prolonged AE an activated partial thromboplastin time prolonged AE that is greater than 2.5 times the upper limit of normal; hemorrhage CTCAE: E12076 MW, YH Grade 1 alanine aminotransferase level increased AE MW, YH CTCAE: E12078 an alanine aminotransferase level increased AE that is greater than the upper limit of normal to 3 times the upper limit of normal Grade 2 alanine aminotransferase level increased AE an alanine aminotransferase level increased AE that is greater than 3 to 5 times the upper limit of normal CTCAE: E12079 MW, YH Grade 3 alanine aminotransferase level increased AE an alanine aminotransferase level increased AE that is greater than 5 to 20 times the upper limit of normal MW, YH CTCAE: E12080 Grade 4 alanine aminotransferase level increased AE an alanine aminotransferase level increased AE that is greater than 20 times the upper limit of normal CTCAE: E12081 MW, YH Grade 2 anal ulcer AE CTCAE: E10498 MW, YH an anal ulcer AE that is symptomatic; altered GI function Grade 3 anal ulcer AE an anal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling CTCAE: E10499 MW, YH Grade 3 atrial flutter AE CTCAE: E10090 an atrial flutter AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation MW, YH Grade 2 otitis media AE MW, YH an otitis media AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11478 Grade 3 otitis media AE CTCAE: E11479 an otitis media AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 1 pericarditis AE CTCAE: E10181 MW, YH a pericarditis AE that has asymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis Grade 2 pericarditis AE CTCAE: E10182 MW, YH a pericarditis AE that has symptomatic pericarditis (e.g., chest pain) Grade 3 pericarditis AE MW, YH a pericarditis AE that has pericarditis with physiologic consequences (e.g., pericardial constriction) CTCAE: E10183 Grade 2 pharyngitis AE a pharyngitis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11526 MW, YH Grade 3 pharyngitis AE MW, YH CTCAE: E11527 a pharyngitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 1 fever AE MW, YH a fever AE that has 38.0 - 39.0 degrees C (100.4 - 102.2 degrees F) CTCAE: E11103 Grade 2 fever AE CTCAE: E11104 a fever AE that has greater than 39.0 - 40.0 degrees C (102.3 - 104.0 degrees F) MW, YH Grade 3 fever AE a fever AE that has greater than 40.0 degrees C (greater than104.0 degrees F) for less than or equal to 24 hrs CTCAE: E11105 MW, YH Grade 4 fever AE a fever AE that has greater than 40.0 degrees C (greater than104.0 degrees F) for more than 24 hrs CTCAE: E11106 MW, YH Grade 1 injection-site adverse event MW, YH CTCAE: E11139 an injection-site adverse event characterized by tenderness with or without associated symptoms (e.g., warmth, erythema, itching) Grade 2 injection-site adverse event CTCAE: E11140 an injection-site adverse event characterized by pain; lipodystrophy; edema; phlebitis MW, YH Grade 3 injection-site adverse event MW, YH an injection-site adverse event characterized by ulceration or necrosis; severe tissue damage; operative intervention indicated CTCAE: E11141 Grade 3 leukocytosis AE CTCAE: E10049 a leukocyte cell number increased AE where leukocytes are greater than 100,000/mm3 MW, YH Grade 4 leukocytosis AE MW, YH CTCAE: E10050 a leukocyte cell number increased AE that has clinical manifestations of leucostasis; urgent intervention indicated Grade 1 leukocyte cell number decreased AE CTCAE: E12233 MW, YH a leukocyte cell number decreased AE that is less than the lower limit of normal - 3000/mm3; less than the lower limit of normal - 3.0 x 10e9 /L Grade 2 leukocyte cell number decreased AE CTCAE: E12234 a leukocyte cell number decreased AE that is less than 3000 - 2000/mm3; less than 3.0 - 2.0 x 10e9 /L MW, YH Grade 3 leukocyte cell number decreased AE MW, YH a leukocyte cell number decreased AE that is less than 2000 - 1000/mm3; less than 2.0 - 1.0 x 10e9 /L CTCAE: E12235 Grade 4 leukocyte cell number decreased AE CTCAE: E12236 MW, YH a leukocyte cell number decreased AE that is less than 1000/mm3; less than 1.0 x 10e9 /L Grade 1 malaise AE a malaise AE that has uneasiness or lack of well being CTCAE: E11153 MW, YH Grade 2 malaise AE CTCAE: E11154 MW, YH a malaise AE that has uneasiness or lack of well being; limiting instrumental activities of daily living Grade 1 chills AE MW, YH a chills AE that has mild sensation of cold; shivering; chattering of teeth CTCAE: E11075 Grade 2 chills AE CTCAE: E11076 A chills AE that has moderate tremor of the entire body; narcotics indicated MW, YH Grade 3 chills AE MW, YH a chills AE that has severe or prolonged, not responsive to narcotics CTCAE: E11077 Grade 1 edema face AE CTCAE: E11083 an edema face AE that has localized facial edema MW, YH Grade 3 meningitis AE CTCAE: E11459 MW, YH a meningitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated; focal neurologic deficit Grade 2 serum sickness AE CTCAE: E11278 a serum sickness AE that has moderate arthralgia; fever, rash, urticaria, antihistamines indicated MW, YH Grade 3 serum sickness AE a serum sickness AE that has severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated MW, YH CTCAE: E11279 Grade 2 urinary tract infection AE CTCAE: E11615 MW, YH a urinary tract infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 urinary tract infection AE a urinary tract infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11616 Grade 2 laryngitis AE a laryngitis AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH CTCAE: E11436 Grade 3 laryngitis AE CTCAE: E11437 a laryngitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 1 dry mouth AE CTCAE: E10579 MW, YH a dry mouth AE that is symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow greater than0.2 ml/min Grade 2 dry mouth AE CTCAE: E10580 MW, YH a dry mouth AE that has moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min Grade 3 dry mouth AE MW, YH a dry mouth AE that has the inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min CTCAE: E10581 Grade 2 pustular rash AE a pustular rash AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11546 MW, YH Grade 3 pustular rash AE CTCAE: E11547 MW, YH a pustular rash AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 2 flatulence AE CTCAE: E10699 MW, YH a flatulence AE that has moderate; persistent; psychosocial sequelae Grade 1 weight loss AE MW, YH a weight loss AE that is 5 to less than 10% from baseline; intervention not indicated CTCAE: E12229 Grade 2 weight loss AE a weight loss AE that is 10 - less than 20% from baseline; nutritional support indicated CTCAE: E12230 MW, YH Grade 3 weight loss AE MW, YH a weight loss AE that is greater than or equal to 20% from baseline; tube feeding or TPN indicated CTCAE: E12231 Grade 1 abnormal gait AE CTCAE: E11113 an abnormal gait AE that has mild change in gait (e.g., wide-based, limping or hobbling) MW, YH Grade 2 abnormal gait AE CTCAE: E11114 an abnormal gait AE that has moderate change in gait (e.g., wide-based, limping or hobbling); assistive device indicated; limiting instrumental activities of daily living MW, YH Grade 1 anemia AE MW, YH CTCAE: E10011 an anemia AE where hemoglobin (Hgb) is less than the lower limit of normal (LLN), which is 10.0 g/dL, 6.2 mmol/L, or 100 g/L. Grade 2 anemia AE CTCAE: E10012 an anemia AE where hemoglobin (Hgb) is less than 10.0-8.0 g/dL, 6.2 -4.9 mmol/L, or 100 - 80 g/L. MW, YH Grade 3 anemia AE MW, YH an anemia AE where hemoglobin (Hgb) is less than 8.0 g/dL, 4.9 mmol/L, or 80 g/L. CTCAE: E10013 Grade 2 sinusitis AE a sinusitis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11564 MW, YH Grade 3 sinusitis AE CTCAE: E11565 MW, YH a sinusitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 1 allergy AE an allergy AE that has transient flushing or rash, drug fever <38 degrees C (<100.4 degrees F); intervention not indicated MW, YH CTCAE: E11249 Grade 2 allergy AE MW, YH CTCAE: E11250 an allergy AE where intervention or infusion interruption indicated; responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics); prophylactic medications indicated for less than or equal to 24 hrs Grade 3 allergy AE CTCAE: E11251 an allergy AE that is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) MW, YH Grade 1 dysphagia AE a dysphagia AE that is symptomatic, able to eat regular diet CTCAE: E10622 MW, YH Grade 2 dysphagia AE CTCAE: E10623 a dysphagia AE that is symptomatic and altered eating/swallowing MW, YH Grade 3 dysphagia AE a dysphagia AE that has severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated MW, YH CTCAE: E10624 Grade 1 platelet count decreased AE MW, YH CTCAE: E12208 a platelet count decreased AE that is less than the lower limit of normal - 75,000/mm3; less than the lower limit of normal - 75.0 x 10e9 /L Grade 2 platelet count decreased AE a platelet count decreased AE that is less than 75,000 - 50,000/mm3; less than 75.0 - 50.0 x 10e9 /L MW, YH CTCAE: E12209 Grade 3 platelet count decreased AE MW, YH CTCAE: E12210 a platelet count decreased AE that is less than 50,000 - 25,000/mm3; less than 50.0 - 25.0 x 10e9 /L Grade 4 platelet count decreased AE a platelet count decreased AE that is less than 25,000/mm3; less than 25.0 x 10e9 /L CTCAE: E12211 MW, YH Grade 1 vomiting AE a vomiting AE that has 1 - 2 episodes (separated by 5 minutes) in 24 hrs CTCAE: E11069 MW, YH Grade 2 vomiting AE a vomiting AE that has 3 - 5 episodes (separated by 5 minutes) in 24 hrs CTCAE: E11070 MW, YH Grade 3 vomiting AE MW, YH CTCAE: E11071 a vomiting AE that has 6 or more episodes (separated by 5 minutes) in 24 hrs; tube feeding, TPN or hospitalization indicated Grade 1 constipation AE CTCAE: E10563 a constipation AE that has occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema MW, YH Grade 2 constipation AE CTCAE: E10564 MW, YH a constipation AE that has persistent symptoms with regular use of laxatives or enemas; limiting instrumental activities of daily living Grade 3 constipation AE a constipation AE that has obstipation with manual evacuation indicated; limiting self care activities of daily living CTCAE: E10565 MW, YH Grade 2 lymphocyte count increased AE CTCAE: E12196 MW, YH a lymphocyte count increased AE that is greater than 4000/mm3 - 20,000/mm3 Grade 3 lymphocyte count increased AE MW, YH a lymphocyte count increased AE that is greater than 20,000/mm3 CTCAE: E12197 Grade 2 hypothermia AE a hypothermia AE that has 35 - greater than 32 degrees C; 95 - greater than 89.6 degrees F MW, YH CTCAE: E11123 Grade 3 hypothermia AE CTCAE: E11124 MW, YH a hypothermia AE that has 32 - greater than 28 degrees C; 89.6 - greater than 82.4 degrees F Grade 4 hypothermia AE CTCAE: E11125 MW, YH a hypothermia AE that has less than or equal to 28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation) Grade 1 hematoma AE MW, YH a hematoma AE that is localized or in a dependent area CTCAE: E11667 Grade 2 hematoma AE CTCAE: E11668 MW, YH a hematoma AE that is generalized Grade 1 aspartate aminotransferase level increased AE an aspartate aminotransferase level increased AE that is greater than the upper limit of normal to 3 times the upper limit of normal CTCAE: E12088 MW, YH Grade 2 aspartate aminotransferase level increased AE MW, YH CTCAE: E12089 an aspartate aminotransferase level increased AE that is greater than 3 to 5 times the upper limit of normal Grade 3 aspartate aminotransferase level increased AE an aspartate aminotransferase level increased AE that is greater than 5 to 20 times the upper limit of normal MW, YH CTCAE: E12090 Grade 4 aspartate aminotransferase level increased AE an aspartate aminotransferase level increased AE that is greater than 20 times the upper limit of normal MW, YH CTCAE: E12091 Grade 3 atrial fibrillation AE CTCAE: E10084 MW, YH an atrial fibrillation AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation Grade 1 blood alkaline phosphatase increased AE a blood alkaline phosphatase increased AE that is greater than the upper limit of normal to 2.5 times the upper limit of normal CTCAE: E12083 MW, YH Grade 2 blood alkaline phosphatase increased AE CTCAE: E12084 MW, YH a blood alkaline phosphatase increased AE that is greater than 2.5 to 5 times the upper limit of normal Grade 3 blood alkaline phosphatase increased AE CTCAE: E12085 MW, YH a blood alkaline phosphatase increased AE that is greater than 5 to 20 times the upper limit of normal Grade 4 blood alkaline phosphatase increased AE CTCAE: E12086 MW, YH a blood alkaline phosphatase increased AE that is greater than 20 times the upper limit of normal Grade 1 blood amylase level increased AE a blood amylase level increased AE that is greater than the upper limit of normal - 1.5 times the upper limit of normal CTCAE: E12213 MW, YH Grade 2 blood amylase level increased AE MW, YH CTCAE: E12214 a blood amylase level increased AE that is greater than 1.5 - 2.0 times the upper limit of normal Grade 3 blood amylase level increased AE a blood amylase level increased AE that is greater than 2.0 - 5.0 times the upper limit of normal MW, YH CTCAE: E12215 Grade 4 blood amylase level increased AE CTCAE: E12216 MW, YH a blood amylase level increased AE that is greater than 5.0 times the upper limit of normal Grade 1 blood bilirubin level increased AE CTCAE: E12097 MW, YH a blood bilirubin level increased AE that is greater than the upper limit of normal to 1.5 times the upper limit of normal Grade 2 blood bilirubin level increased AE a blood bilirubin level increased AE that is greater than 1.5 to 3 times the upper limit of normal MW, YH CTCAE: E12098 Grade 3 blood bilirubin level increased AE MW, YH a blood bilirubin level increased AEgreater than3.0 - 10.0 x upper limit of normal CTCAE: E12099 Grade 4 blood bilirubin level increased AE CTCAE: E12100 a blood bilirubin level increased AE that is greater than 10 times the upper limit of normal MW, YH Grade 1 blood cholesterol increased AE a blood cholesterol increased AE that is greater than the upper limit of normal to 300 mg/dL; greater than the upper limit of normal to 7.75 mmol/L MW, YH CTCAE: E12128 Grade 2 blood cholesterol increased AE MW, YH CTCAE: E12129 a blood cholesterol increased AE that is greater than 300 - 400 mg/dL; greater than 7.75 - 10.34 mmol/L Grade 3 blood cholesterol increased AE MW, YH CTCAE: E12130 a blood cholesterol increased AE that is greater than 400 - 500 mg/dL; greater than 10.34 - 12.92 mmol/L Grade 4 blood cholesterol increased AE CTCAE: E12131 a blood cholesterol increased AE that is greater than 500 mg/dL; greater than 12.92 mmol/L MW, YH Grade 1 blood creatinine level increased AE CTCAE: E12138 a blood creatinine level increased AE that is greater than 1 - 1.5 times the baseline; greater than the upper limit of normal - 1.5 times the upper limit of normal MW, YH Grade 2 blood creatinine level increased AE a blood creatinine level increased AE that is greater than 1.5 - 3.0 times the baseline; greater than 1.5 - 3.0 times the upper limit of normal MW, YH CTCAE: E12139 Grade 3 blood creatinine level increased AE MW, YH CTCAE: E12140 a blood creatinine level increased AE that is greater than 3.0 times the baseline; greater than 3.0 - 6.0 times the upper limit of normal Grade 4 blood creatinine level increased AE CTCAE: E12141 a blood creatinine level increased AE that is greater than 6.0 times the upper limit of normal MW, YH Grade 1 bone marrow depression AE MW, YH a bone marrow depression AE categorized as mildly hypocellular or less than or equal to 25% reduction from normal cellularity for age CTCAE: E10023 Grade 2 bone marrow depression AE a bone marrow depression AE categorized as moderately hypocellular or greater than 25 to less than 50% reduction from normal cellularity for age CTCAE: E10024 MW, YH Grade 3 bone marrow depression AE CTCAE: E10025 MW, YH a bone marrow depression AE cateogirzed as severely hypocellular or greater than 50 to less than or equal to 75% reduction cellularity from normal for age Grade 4 bone marrow depression AE a bone marrow depression AE categorized as aplastic persistent for longer than 2 weeks CTCAE: E10026 MW, YH Grade 2 breast infection AE MW, YH CTCAE: E11319 a breast infection AE that has local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 3 breast infection AE a breast infection AE that has severe infection; axillary adenitis; IV antibacterial, antifungal, or antiviral intervention indicated CTCAE: E11320 MW, YH Grade 1 cardiac failure AE a cardiac failure AE that is asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities CTCAE: E10125 MW, YH Grade 2 cardiac failure AE a cardiac failure AE that has symptoms with mild to moderate activity or exertion CTCAE: E10126 MW, YH Grade 3 cardiac failure AE a cardiac failure AE that has severe with symptoms at rest or with minimal activity or exertion; intervention indicated MW, YH CTCAE: E10127 Grade 4 cardiac failure AE MW, YH CTCAE: E10128 a cardiac failure AE that has life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) Grade 2 cataract AE a cataract AE that is symptomatic; moderate decrease in visual acuity (20/40 or better) CTCAE: E10352 MW, YH Grade 3 cataract AE MW, YH a cataract AE that is symptomatic with marked decrease in visual acuity (worse than 20/40 but better than 20/200); operative intervention indicated (e.g., cataract surgery) CTCAE: E10353 Grade 4 cataract AE a cataract AE that is characterized by blindness (20/200 or worse) in the affected eye CTCAE: E10354 MW, YH Grade 2 catheter related infection AE CTCAE: E11329 a catheter related infection AE that is localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 3 catheter related infection AE MW, YH a catheter related infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11330 Grade 2 colitis AE a colitis AE that has abdominal pain; mucus or blood in stool CTCAE: E10523 MW, YH Grade 3 colitis AE CTCAE: E10524 MW, YH a colitis AE that has severe abdominal pain; change in bowel habits; medical intervention indicated; peritoneal signs Grade 1 cytokine release syndrome AE CTCAE: E11265 a cytokine release syndrome AE that has a mild reaction; infusion interruption not indicated; intervention not indicated MW, YH Grade 2 cytokine release syndrome AE a cytokine release syndrome AE where therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for less than or equal to 24 hrs MW, YH CTCAE: E11266 Grade 3 cytokine release syndrome AE MW, YH a cytokine release syndrome AEthat is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) CTCAE: E11267 Grade 1 dental caries AE a dental caries AE that has one or more dental caries, not involving the root CTCAE: E10569 MW, YH Grade 2 dental caries AE MW, YH a dental caries AE that has dental caries involving the root CTCAE: E10570 Grade 3 dental caries AE CTCAE: E10571 a dental caries AE that has dental caries resulting in pulpitis or periapical abscess or resulting in tooth loss MW, YH Grade 3 device related infection AE a device related infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11357 Grade 2 disseminated intravascular coagulation AE a disseminated intravascular coagulation AE that has laboratory findings with no bleeding CTCAE: E10029 MW, YH Grade 3 disseminated intravascular coagulation AE MW, YH a disseminated intravascular coagulation AE that has laboratory findings and bleeding CTCAE: E10030 Grade 2 ejection fraction decreased AE CTCAE: E12143 MW, YH an ejection fraction decreased AE where the resting ejection fraction (EF) 50 - 40%; 10 - 19% drop from baseline Grade 3 ejection fraction decreased AE MW, YH CTCAE: E12144 an ejection fraction decreased AE where the resting ejection fraction (EF) 39 - 20%; greater than 20% drop from baseline Grade 4 ejection fraction decreased AE CTCAE: E12145 MW, YH an ejection fraction decreased AE where the resting ejection fraction (EF) less than 20% Grade 1 electrocardiogram qt prolonged AE MW, YH CTCAE: E12147 an electrocardiogram qt prolonged AE where the QTc 450 - 480 ms Grade 2 electrocardiogram qt prolonged AE MW, YH CTCAE: E12148 an electrocardiogram qt prolonged AE where the QTc 481 - 500 ms Grade 3 electrocardiogram qt prolonged AE an electrocardiogram qt prolonged AE where the QTc is greater than or equal to 501 ms on at least two separate ECGs CTCAE: E12149 MW, YH Grade 4 electrocardiogram qt prolonged AE CTCAE: E12150 an electrocardiogram qt prolonged AE where the QTc is greater than or equal to 501 or greater than 60 ms change from baseline and Torsade de pointes or polymorphic ventricular tachycardia or signs/symptoms of serious arrhythmia MW, YH Grade 2 enterocolitis AE MW, YH an enterocolitis AE that has abdominal pain; mucus or blood in stool CTCAE: E10629 Grade 3 enterocolitis AE MW, YH CTCAE: E10630 an enterocolitis AE that has severe or persistent abdominal pain; fever; ileus; peritoneal signs Grade 1 fall AE a fall AE that is minor with no resultant injuries; intervention not indicated CTCAE: E11688 MW, YH Grade 3 fall AE a fall AE where hospitalization indicated MW, YH CTCAE: E11690 Grade 3 febrile neutropenia AE CTCAE: E10034 a febrile neutropenia AE categorized as anC less than 1000/mm3 with a single temperature of greater than 38.3 degrees C (101 degrees F) or a sustained temperature of greater than or equal to 38 degrees C (100.4 degrees F) for more than one hour. MW, YH Grade 1 forced expiratory volume decreased AE MW, YH CTCAE: E12157 a forced expiratory volume decreased AE where FEV1% (percentages of observed FEV1 and FVC related to their respective predicted values) 99 - 70% predicted Grade 2 forced expiratory volume decreased AE MW, YH CTCAE: E12158 a forced expiratory volume decreased AE where FEV1 60 - 69% Grade 3 forced expiratory volume decreased AE MW, YH a forced expiratory volume decreased AE where FEV1 50 - 59% CTCAE: E12159 Grade 4 forced expiratory volume decreased AE CTCAE: E12160 a forced expiratory volume decreased AE where FEV1 is less than or equal to 49% MW, YH Grade 2 fracture AE CTCAE: E11705 a fracture AE that is symptomatic but non-displaced; immobilization indicated MW, YH Grade 3 fracture AE CTCAE: E11706 MW, YH a fracture AE that has severe symptoms; displaced or open wound with bone exposure; disabling; operative intervention indicated Grade 1 gamma-glutamyltransferase level increased AE MW, YH CTCAE: E12162 a gamma-glutamyltransferase level increased AE that is greater than the upper limit of normal - 2.5 times upper limit of normal Grade 2 gamma-glutamyltransferase level increased AE CTCAE: E12163 MW, YH a gamma-glutamyltransferase level increased AE that is greater than 2.5 - 5.0 times the upper limit of normal Grade 3 gamma-glutamyltransferase level increased AE CTCAE: E12164 a gamma-glutamyltransferase level increased AE that is greater than 5.0 - 20.0 times the upper limit of normal MW, YH Grade 4 gamma-glutamyltransferase level increased AE MW, YH a gamma-glutamyltransferase level increased AE that is greater than 20.0 times the upper limit of normal CTCAE: E12165 Grade 2 gastric ulcer AE a gastric ulcer AE that is symptomatic; altered GI function; medical intervention indicated; limiting instrumental activities of daily living CTCAE: E10729 MW, YH Grade 3 gastric ulcer AE MW, YH a gastric ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care activities of daily living; disabling CTCAE: E10730 Grade 2 gastritis AE CTCAE: E10735 MW, YH a gastritis AE that is symptomatic; altered GI function; medical intervention indicated Grade 3 gastritis AE MW, YH a gastritis AE that has severely altered eating or gastric function; TPN or hospitalization indicated CTCAE: E10736 Grade 1 hemolytic uremic syndrome AE a hemolytic uremic syndrome AE that has evidence of RBC destruction (schistocytosis) without clinical consequences MW, YH CTCAE: E10044 Grade 3 hemolytic uremic syndrome AE MW, YH CTCAE: E10045 a hemolytic uremic syndrome AE that has laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) Grade 4 hemolytic uremic syndrome AE MW, YH CTCAE: E10046 a hemolytic uremic syndrome AE that has life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) Grade 3 hemorrhoidal hemorrhage AE MW, YH CTCAE: E10770 a hemorrhoidal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 hepatic failure AE MW, YH CTCAE: E11212 a hepatic failure AE that has asterixis; mild encephalopathy; limiting self care activities of daily living Grade 4 hepatic failure AE CTCAE: E11213 a hepatic failure AE that has moderate to severe encephalopathy; coma; life-threatening consequences MW, YH Grade 3 hepatitis viral AE CTCAE: E11412 a hepatitis viral AE that has symptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; reactivation of chronic hepatitis MW, YH Grade 4 hepatitis viral AE a hepatitis viral AE that has decompensated liver function (e.g., ascites, coagulopathy, encephalopathy, coma) CTCAE: E11413 MW, YH Grade 2 ileus AE MW, YH an ileus AE that is symptomatic; altered GI function; bowel rest indicated CTCAE: E10813 Grade 3 ileus AE an ileus AE that has severely altered GI function; TPN indicated CTCAE: E10814 MW, YH Grade 1 infusion related reaction AE an infusion related reaction AE that has mild transient reaction; infusion interruption not indicated; intervention not indicated CTCAE: E11128 MW, YH Grade 2 infusion related reaction AE an infusion related reaction AE where therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for less than or equal to 24 hrs MW, YH CTCAE: E11129 Grade 3 infusion related reaction AE MW, YH an infusion related reaction AE that is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae CTCAE: E11130 Grade 2 infusion site extravasation AE an infusion site extravasation AE that has erythema with associated symptoms (e.g., edema, pain, induration, phlebitis) MW, YH CTCAE: E11134 Grade 3 infusion site extravasation AE CTCAE: E11135 MW, YH an infusion site extravasation AE that has ulceration or necrosis; severe tissue damage; operative intervention indicated Grade 1 irritability AE an irritability AE that has mild; easily consolable MW, YH CTCAE: E11145 Grade 2 irritability AE an irritability AE that has moderate; limiting instrumental activities of daily living; increased attention indicated CTCAE: E11146 MW, YH Grade 3 irritability AE MW, YH an irritability AE that has severe abnormal or excessive response; limiting self care activities of daily living; inconsolable CTCAE: E11147 Grade 3 left venticular systolic dysfuction AE CTCAE: E10131 a left ventricular dysfunction AE that has symptomatic due to drop in ejection fraction responsive to intervention MW, YH Grade 4 left ventricular systolic dysfuction AE MW, YH a left ventricular dysfunction AE chracterized as refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated CTCAE: E10132 Grade 1 lipase increased AE a lipase increased AE that is greater than the upper limit of normal - 1.5 times upper limit of normal CTCAE: E12186 MW, YH Grade 2 lipase increased AE MW, YH a lipase increased AE that is greater than 1.5 - 2.0 times upper limit of normal CTCAE: E12187 Grade 3 lipase increased AE a lipase increased AE that is greater than 2.0 - 5.0 times upper limit of normal CTCAE: E12188 MW, YH Grade 4 lipase increased AE a lipase increased AE that is greater than 5.0 times upper limit of normal MW, YH CTCAE: E12189 Grade 1 localized edema AE a localized edema AE that has localized to dependent areas, no disability or functional impairment MW, YH CTCAE: E11149 Grade 2 lung infection AE MW, YH a lung infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11445 Grade 3 lung infection AE MW, YH a lung infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated CTCAE: E11446 Grade 1 lymphocyte count decreased AE a lymphocyte count decreased AE that is less than the lower limit of normal - 800/mm3; less than the lower limit of normal - 0.8 x 10e9 /L CTCAE: E12191 MW, YH Grade 2 lymphocyte count decreased AE MW, YH CTCAE: E12192 a lymphocyte count decreased AE that is less than 800 - 500/mm3; less than 0.8 - 0.5 x 10e9 /L Grade 3 lymphocyte count decreased AE MW, YH CTCAE: E12193 a lymphocyte count decreased AE that is less than 500 - 200/mm3; less than 0.5 - 0.2 x 10e9 /L Grade 4 lymphocyte count decreased AE MW, YH CTCAE: E12194 a lymphocyte count decreased AE that is less than 200/mm3; less than 0.2 x 10e9 /L Grade 1 myocarditis AE a myocarditis AE that has asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities MW, YH CTCAE: E10158 Grade 2 myocarditis AE MW, YH CTCAE: E10159 a myocarditis AE that has symptoms with mild to moderate activity or exertion Grade 3 myocarditis AE CTCAE: E10160 a myocarditis AE that has severe with symptoms at rest or with minimal activity or exertion; intervention indicated MW, YH Grade 4 myocarditis AE MW, YH a myocarditis AE that has life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) CTCAE: E10161 Grade 1 neutrophil count decreased AE CTCAE: E12199 a neutrophil count decreased AE that is less than the lower limit of normal - 1500/mm3; less than the lower limit of normal - 1.5 x 10e9 /L MW, YH Grade 2 neutrophil count decreased AE CTCAE: E12200 MW, YH a neutrophil count decreased AE that is less than 1500 - 1000/mm3; less than 1.5 - 1.0 x 10e9 /L Grade 3 neutrophil count decreased AE MW, YH a neutrophil count decreased AE that is less than 1000 - 500/mm3; less than 1.0 - 0.5 x 10e9 /L CTCAE: E12201 Grade 4 neutrophil count decreased AE CTCAE: E12202 a neutrophil count decreased AE that is less than 500/mm3; less than 0.5 x 10e9 /L MW, YH Grade 2 esophageal stenosis AE MW, YH an esophageal stenosis AE that is symptomatic; altered GI function CTCAE: E10672 Grade 3 esophageal stenosis AE CTCAE: E10673 MW, YH an esophageal stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated Grade 2 esophagitis AE CTCAE: E10689 MW, YH an esophagitis AE that is symptomatic; altered eating/swallowing; oral supplements indicated Grade 3 esophagitis AE CTCAE: E10690 an esophagitis AE that has severely altered eating/swallowing; tube feeding, TPN or hospitalization indicated MW, YH Grade 2 oral cavity fistula AE MW, YH CTCAE: E10890 an oral cavity fistula AE that is symptomatic; altered GI function Grade 3 oral cavity fistula AE an oral cavity fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated MW, YH CTCAE: E10891 Grade 2 papilledema AE a papilloedema AE that has a symptomatic decline in vision; visual field defect present sparing the central 20 degrees CTCAE: E10413 MW, YH Grade 3 papilledema AE MW, YH CTCAE: E10414 a papilloedema AE that has a marked visual field defect (worse than 20/40 but better than 20/200) Grade 4 papilledema AE a papilloedema AE that has blindness (20/200 or worse) in the affected eye CTCAE: E10415 MW, YH Grade 2 pericardial effusion AE MW, YH CTCAE: E10173 a pericardial effusion AE that has asymptomatic effusion size small to moderate Grade 3 pericardial effusion AE CTCAE: E10174 a pericardial effusion AE that has effusion with physiologic consequences MW, YH Grade 2 portal hypertension AE MW, YH CTCAE: E11239 a portal hypertension AE that has decreased portal vein flow Grade 3 portal hypertension AE CTCAE: E11240 a portal hypertension AE that has reversal/retrograde portal vein flow; associated with varices and/or ascites MW, YH Grade 1 dermatitis radiation AE MW, YH CTCAE: E11676 a dermatitis radiation AE that has faint erythema or dry desquamation Grade 2 dermatitis radiation AE MW, YH a dermatitis radiation AE that has moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema CTCAE: E11677 Grade 3 dermatitis radiation AE MW, YH CTCAE: E11678 a dermatitis radiation AE that has moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion Grade 4 dermatitis radiation AE CTCAE: E11679 MW, YH a dermatitis radiation AE that has life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated Grade 3 rectal hemorrhage AE a rectal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH CTCAE: E10958 Grade 1 skin infection AE CTCAE: E11569 MW, YH a skin infection AE that is localized, local intervention indicated Grade 2 skin infection AE a skin infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11570 MW, YH Grade 3 skin infection AE a skin infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11571 Grade 2 small intestinal obstruction AE CTCAE: E11023 MW, YH a small intestinal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living Grade 2 small intestinal stenosis AE MW, YH a small intestinal stenosis AE that is symptomatic; altered GI function CTCAE: E11034 Grade 3 small intestinal stenosis AE CTCAE: E11035 a small intestinal stenosis AE that is symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated MW, YH Grade 2 soft tissue infection AE MW, YH CTCAE: E11580 a soft tissue infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 soft tissue infection AE a soft tissue infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11581 MW, YH Grade 3 gastric hemorrhage AE CTCAE: E10709 MW, YH a gastric hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 2 tracheitis AE a tracheitis AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH CTCAE: E11600 Grade 3 tracheitis AE a tracheitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated CTCAE: E11601 MW, YH Grade 3 upper gastrointestinal hemorrhage AE MW, YH CTCAE: E11065 an upper gastrointestinal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 3 urine output decreased AE a urine output decreased AE that has oliguria (less than 80 ml in 8 hr) CTCAE: E12218 MW, YH Grade 4 urine output decreased AE MW, YH a urine output decreased AE that has anuria (less than 240 ml in 24 hr) CTCAE: E12219 Grade 2 vaginal infection AE CTCAE: E11625 MW, YH a vaginal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 vaginal infection AE MW, YH a vaginal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11626 Grade 2 venous injury AE CTCAE: E12053 MW, YH a venous injury AE that is symptomatic (e.g., claudication); repair or revision not indicated Grade 3 venous injury AE a venous injury AE that has severe symptoms; limiting self care activities of daily living; repair or revision indicated; disabling MW, YH CTCAE: E12054 Grade 4 venous injury AE CTCAE: E12055 MW, YH a venous injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated Grade 1 weight increased AE CTCAE: E12225 a weight increased AE that is 5 - less than 10% from baseline MW, YH Grade 2 weight increased AE a weight increased AE that is 10 - less than 20% from baseline CTCAE: E12226 MW, YH Grade 3 weight increased AE CTCAE: E12227 a weight increased AE that is greater than or equal to 20% from baseline MW, YH Grade 3 Wolff-Parkinson-White syndrom AE CTCAE: E10247 MW, YH a wolff-parkinson-white syndrome AE that is symptomatic and incompletely controlled medically or controlled with procedure Grade 1 wound complication AE CTCAE: E12058 a wound complication AE that has incisional separation of less than or equal to 25% of wound, no deeper than superficial fascia MW, YH Grade 2 wound complication AE MW, YH a wound complication AE that has incisional separation greater than 25% of wound; local care indicated CTCAE: E12059 Grade 3 wound complication AE a wound complication AE that has hernia without evidence of strangulation; fascial disruption/dehiscence; primary wound closure or revision by operative intervention indicated CTCAE: E12060 MW, YH Grade 4 wound complication AE MW, YH a wound complication AE that has hernia with evidence of strangulation; major reconstruction flap, grafting, resection, or amputation indicated CTCAE: E12061 Grade 1 wound dehiscence AE CTCAE: E12064 MW, YH a wound dehiscence AE that has incisional separation of less than or equal to 25% of wound, no deeper than superficial fascia Grade 2 wound dehiscence AE MW, YH CTCAE: E12065 a wound dehiscence AE that has incisional separation greater than 25% of wound with local care; asymptomatic hernia or symptomatic hernia without evidence of strangulation Grade 3 wound dehiscence AE CTCAE: E12066 a wound dehiscence AE that has fascial disruption or dehiscence without evisceration; primary wound closure or revision by operative intervention indicated MW, YH Grade 4 wound dehiscence AE MW, YH a wound dehiscence AE that has life-threatening consequences; symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated CTCAE: E12067 Grade 3 multi-organ failure AE a multi-organ failure AE chracterized by shock with azotemia and acid-base disturbances; significant coagulation abnormalities CTCAE: E11156 MW, YH Grade 4 multi-organ failure AE CTCAE: E11157 a multi-organ failure AE that has life-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis) MW, YH Grade 3 restrictive cardiomyopathy AE MW, YH a restrictive cardiomyopathy AE that has symptomatic heart failure or other cardiac symptoms, responsive to intervention CTCAE: E10193 Grade 4 restrictive cardiomyopathy AE a restrictive cardiomyopathy AE that has refractory heart failure or other poorly controlled cardiac symptoms MW, YH CTCAE: E10194 Grade 3 atrioventricular block complete AE MW, YH CTCAE: E10095 a complete atrioventricular block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) Grade 3 Mobitz type I block AE CTCAE: E10149 MW, YH a Mobitz type I block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) Grade 3 Mobitz type II atrioventricular block AE MW, YH a Mobitz type II block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) CTCAE: E10143 Grade 1 hemoglobin level increased AE a hemoglobin level increased AE where the increase is greater than 0 - 2 gm/dL above upper limit of normal or above baseline if baseline is above upper limit of normal MW, YH CTCAE: E12172 Grade 2 hemoglobin level increased AE MW, YH CTCAE: E12173 a hemoglobin level increased AE where the increase is greater than 2 - 4 gm/dL above the upper limit of normal or above baseline if baseline is above upper limit of normal Grade 3 hemoglobin level increased AE CTCAE: E12174 MW, YH a hemoglobin level increased AE where the increase is greater than 4 gm/dL above the upper limit of normal or above baseline if baseline is above upper limit of normal Grade 1 right ventricular dysfuction AE MW, YH a right ventricular dysfunction AE that has asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities CTCAE: E10197 Grade 2 right ventricular dysfuction AE CTCAE: E10198 a right ventricular dysfunction AE that has symptoms with mild to moderate activity or exertion MW, YH Grade 3 right ventricular dysfuction AE CTCAE: E10199 a right ventricular dysfunction AE that has severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated MW, YH Grade 4 right ventricular dysfunction AE a right ventricular dysfunction AE that has life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated CTCAE: E10200 MW, YH Grade 3 intraoperative hemorrhage AE a Intraoperative hemorrhage AE where postoperative radiologic, endoscopic, or operative intervention indicated MW, YH CTCAE: E11811 Grade 2 uveitis AE MW, YH an uveitis AE that has anterior uveitis; medical intervention indicated CTCAE: E10444 Grade 3 uveitis AE MW, YH CTCAE: E10445 an uveitis AE that has posterior or pan-uveitis Grade 4 uveitis AE CTCAE: E10446 MW, YH an uveitis AE that has blindness (20/200 or worse) in the affected eye Grade 2 retinopathy AE a retinopathy AE that is symptomatic with moderate decrease in visual acuity (20/40 or better); limiting instrumental activities of daily living CTCAE: E10434 MW, YH Grade 3 retinopathy AE a retinopathy AE that is symptomatic with marked decrease in visual acuity (worse than 20/40); disabling; limiting self care activities of daily living CTCAE: E10435 MW, YH Grade 4 retinopathy AE MW, YH CTCAE: E10436 a retinopathy AE that has blindness (20/200 or worse) in the affected eye Grade 1 hearing loss AE CTCAE: E10277 MW, YH a hearing loss AE for adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of 15 - 25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: subjective change in hearing in the absence of documented hearing loss. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift greater than20 dB at 8 kHz in at least one ear. Grade 2 hearing loss AE a hearing loss AE for adults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of greater than25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: hearing loss but hearing aid or intervention not indicated; limiting instrumental activities of daily living. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift greater than20 dB at 4 kHz and above in at least one ear. CTCAE: E10278 MW, YH Grade 3 hearing loss AE CTCAE: E10279 MW, YH a hearing loss AE for adults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of greater than25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated. Adults not enrolled in Monitoring Program: hearing loss with hearing aid or intervention indicated; limiting self care activities of daily living. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): hearing loss sufficient to indicate therapeutic intervention, including hearing aids; threshold shift greater than20 dB at 3 kHz and above in at least one ear; additional speech-language related services indicated. Grade 4 hearing loss AE CTCAE: E10280 a hearing loss AE for adults: Decrease in hearing to profound bilateral loss (absolute threshold greater than80 dB HL at 2 kHz and above); non-servicable hearing. Pediatric: Audiologic indication for cochlear implant and additional speech-language related services indicated. MW, YH Grade 1 international normalized ratio increased AE CTCAE: E12176 MW, YH a international normalized ratio increased AE that is greater than 1 - 1.5 times the upper limit of normal; greater than 1 - 1.5 times above baseline if on anticoagulation Grade 2 international normalized ratio increased AE MW, YH CTCAE: E12177 a international normalized ratio increased AE that is greater than 1.5 - 2.5 times the upper limit of normal; greater than 1.5 - 2.5 times above baseline if on anticoagulation Grade 3 international normalized ratio increased AE a international normalized ratio increased AE that is greater than 2.5 times the upper limit of normal; greater than 2.5 times above baseline if on anticoagulation MW, YH CTCAE: E12178 Grade 1 fecal incontinence AE a fecal incontinence AE that has occasional use of pads required MW, YH CTCAE: E10694 Grade 2 fecal incontinence AE a fecal incontinence AE that has daily use of pads required CTCAE: E10695 MW, YH Grade 3 fecal incontinence AE CTCAE: E10696 MW, YH a fecal incontinence AE that has severe symptoms; elective operative intervention indicated Grade 1 thrombotic thrombocytopenic purpura AE a thrombotic thrombocytopenic purpura AE that has evidence of RBC destruction (schistocytosis) without clinical consequences CTCAE: E10062 MW, YH Grade 3 thrombotic thrombocytopenic purpura AE MW, YH a thrombotic thrombocytopenic purpura AE charaterized by laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) CTCAE: E10063 Grade 4 thrombotic thrombocytopenic purpura AE MW, YH a thrombotic thrombocytopenic purpura AE that has life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) CTCAE: E10064 Grade 1 glaucoma AE a glaucoma AE that has elevated intraocular pressure (EIOP) with single topical agent for intervention; no visual field deficit CTCAE: E10393 MW, YH Grade 2 glaucoma AE MW, YH a glaucoma AE that has elevated intraocular pressure causing early visual field deficits; multiple topical or oral agents indicated; limiting instrumental activities of daily living CTCAE: E10394 Grade 3 glaucoma AE MW, YH a glaucoma AE that has elevated intraocular pressure causing marked visual field deficits (e.g., involving both superior and inferior visual fields); operative intervention indicated; limiting self care activities of daily living CTCAE: E10395 Grade 4 glaucoma AE a glaucoma AE that has blindness (20/200 or worse) in the affected eye CTCAE: E10396 MW, YH Grade 3 anaphylaxis AE MW, YH CTCAE: E11255 an anaphylaxis AE that has symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension Grade 2 retinal detachment AE a retinal detachment AE that has exudative and visual acuity 20/40 or better MW, YH CTCAE: E10422 Grade 3 retinal detachment AE MW, YH CTCAE: E10423 a retinal detachment AE that has rhegmatogenous or exudative detachment; operative intervention indicated; decline in vision (worse than 20/40 but better than 20/200) Grade 4 retinal detachment AE a retinal detachment AE that has blindness (20/200 or worse) in the affected eye CTCAE: E10424 MW, YH Grade 1 hemolysis AE MW, YH CTCAE: E10038 a hemolysis AE that has laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin) Grade 2 hemolysis AE a hemolysis AE that has evidence of hemolysis and greater than or equal to 2 gm decrease in hemoglobin. MW, YH CTCAE: E10039 Grade 3 hemolysis AE MW, YH a hemolysis AE where transfusion or medical intervention is indicated (e.g., steroids) CTCAE: E10040 Grade 2 anal fistula AE MW, YH CTCAE: E10466 an anal fistula AE that is symptomatic; altered GI function Grade 3 anal fistula AE MW, YH an anal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated CTCAE: E10467 Grade 3 atrial tachycardia AE MW, YH CTCAE: E10169 an atrial tachycardia AE where IV medication is indicated Grade 4 atrial tachycardia AE CTCAE: E10170 an atrial tachycardia AE that has life-threatening consequences; incompletely controlled medically; cardioversion indicated MW, YH Grade 3 cholecystitis AE MW, YH a cholecystitis AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated CTCAE: E11186 Grade 1 autoimmune disorder AE an autoimmune disorder AE that is asymptomatic; serologic or other evidence of autoimmune reaction, with normal organ function; intervention not indicated MW, YH CTCAE: E11259 Grade 2 autoimmune disorder AE an autoimmune disorder AE that has evidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism) MW, YH CTCAE: E11260 Grade 3 autoimmune disorder AE CTCAE: E11261 an autoimmune disorder AE that has autoimmune reactions involving major organ (e.g., colitis, anemia, myocarditis, kidney) MW, YH Grade 1 spleen disorder AE a spleen disorder AE that has incidental findings (e.g., Howell-Jolly bodies); mild degree of thrombocytosis and leukocytosis CTCAE: E10057 MW, YH Grade 2 spleen disorder AE CTCAE: E10058 a spleen disorder AE when prophylactic antibiotics are indicated MW, YH Grade 2 burn AE CTCAE: E11671 a burn AE that requires medical intervention; minimal debridement indicated MW, YH Grade 3 burn AE CTCAE: E11672 a burn AE that requires moderate to major debridement or reconstruction indicated MW, YH Grade 1 papulopustular rash AE MW, YH a papulopustular rash AE that has papules and/or pustules covering less than 10% body surface area which may or may not be associated with symptoms of pruritus or tenderness CTCAE: E11492 Grade 2 papulopustular rash AE CTCAE: E11493 a papulopustular rash AE that has papules and/or pustules covering 10-30% body surface area, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental activities of daily living MW, YH Grade 3 papulopustular rash AE MW, YH a papulopustular rash AE that has papules and/or pustules covering greater than 30% body surface area, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care activities of daily living; associated with local superinfection with oral antibiotics indicated CTCAE: E11494 Grade 4 papulopustular rash AE a papulopustular rash AE that has papules and/or pustules covering any % body surface area, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences CTCAE: E11495 MW, YH Grade 2 acute coronary syndrome AE CTCAE: E10067 MW, YH an acute coronary syndrome AE that has symptomatic, progressive angina; cardiac enzymes normal; hemodynamically stable Grade 3 acute coronary syndrome AE an acute coronary syndrome AE that has symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically stable CTCAE: E10068 MW, YH Grade 4 acute coronary syndrome AE CTCAE: E10069 an acute coronary syndrome AE that has symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically unstable MW, YH Grade 1 aortic valve disease AE an aortic valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging CTCAE: E10072 MW, YH Grade 2 aortic valve disease AE an aortic valve disease AE that has symptomatic; moderate regurgitation or stenosis by imaging MW, YH CTCAE: E10073 Grade 3 aortic valve disease AE CTCAE: E10074 an aortic valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention MW, YH Grade 4 aortic valve disease AE CTCAE: E10075 MW, YH an aortic valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 1 asystole AE MW, YH CTCAE: E10078 an asystole AE that has periods of asystole; non-urgent medical management indicated Grade 3 constrictive pericarditis AE a constrictive pericarditis AE that has symptomatic heart failure or other cardiac symptoms, responsive to intervention MW, YH CTCAE: E10121 Grade 4 constrictive pericarditis AE CTCAE: E10122 MW, YH a constrictive pericarditis AE that has refractory heart failure or other poorly controlled cardiac symptoms Grade 1 mitral valve disease AE a mitral valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging CTCAE: E10135 MW, YH Grade 2 mitral valve disease AE MW, YH CTCAE: E10136 a mitral valve disease AE that has asymptomatic; moderate regurgitation or stenosis by imaging Grade 3 mitral valve disease AE a mitral valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention MW, YH CTCAE: E10137 Grade 4 mitral valve disease AE MW, YH CTCAE: E10138 a mitral valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 1 pulmonary valve disease AE a pulmonary valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging MW, YH CTCAE: E10187 Grade 2 pulmonary valve disease AE MW, YH a pulmonary valve disease AE that has asymptomatic; moderate regurgitation or stenosis by imaging CTCAE: E10188 Grade 3 pulmonary valve disease AE MW, YH CTCAE: E10189 a pulmonary valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention Grade 4 pulmonary valve disease AE CTCAE: E10190 MW, YH a pulmonary valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 1 tricuspid valve disease AE a tricuspid valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis MW, YH CTCAE: E10225 Grade 2 tricuspid valve disease AE a tricuspid valve disease AE that is asymptomatic; moderate regurgitation or stenosis by imaging MW, YH CTCAE: E10226 Grade 3 tricuspid valve disease AE a tricuspid valve disease AE that is symptomatic; severe regurgitation or stenosis; symptoms controlled with medical intervention CTCAE: E10227 MW, YH Grade 4 tricuspid valve disease AE CTCAE: E10228 MW, YH a tricuspid valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) Grade 1 external ear inflammation AE CTCAE: E10267 an external ear inflammation AE that has external otitis with erythema or dry desquamation MW, YH Grade 2 external ear inflammation AE an external ear inflammation AE that has external otitis with moist desquamation, edema, enhanced cerumen or discharge; tympanic membrane perforation; tympanostomy MW, YH CTCAE: E10268 Grade 3 external ear inflammation AE an external ear inflammation AE that has external otitis with mastoiditis; stenosis or osteomyelitis; necrosis of soft tissue or bone MW, YH CTCAE: E10269 Grade 4 external ear inflammation AE an external ear inflammation AE where urgent operative intervention indicated MW, YH CTCAE: E10270 Grade 1 middle ear inflammation AE CTCAE: E10282 MW, YH a middle ear inflammation AE that has serous otitis Grade 2 middle ear inflammation AE MW, YH CTCAE: E10283 a middle ear inflammation AE that has serous otitis, medical intervention indicated Grade 3 middle ear inflammation AE MW, YH a middle ear inflammation AE that has mastoiditis; necrosis of canal soft tissue or bone CTCAE: E10284 Grade 2 delayed puberty AE CTCAE: E10309 a delayed puberty AE that has no breast development by age 13 yrs for females; testes volume of <3 cc or no Tanner Stage 2 development by age 14.5 yrs for males MW, YH Grade 3 delayed puberty AE a delayed puberty AE that has no breast development by age 14 yrs for females; no increase in testes volume or no Tanner Stage 2 by age 16 yrs for males; hormone replacement indicated MW, YH CTCAE: E10310 Grade 2 growth accelerated AE CTCAE: E10318 a growth accelerated AE that has greater than or equal to +2 SD (standard deviation) above mid parental height or target height MW, YH Grade 1 precocious puberty AE MW, YH a precocious puberty AE that has physical signs of puberty with no biochemical markers for females younger than 8 years and males younger than 9 years CTCAE: E10341 Grade 2 precocious puberty AE CTCAE: E10342 a precocious puberty AE that has physical signs and biochemical markers of puberty for females younger than 8 years and males younger than 9 years MW, YH Grade 3 corneal ulcer AE MW, YH a corneal ulcer AE that has limiting self care activities of daily living declining vision (worse than 20/40 but better than 20/200) CTCAE: E10361 Grade 4 corneal ulcer AE CTCAE: E10362 MW, YH a corneal ulcer AE that has perforation or blindness (20/200 or worse) in the affected eye Grade 1 dry eye AE MW, YH a dry eye AE that is asymptomatic; clinical or diagnostic observations only; mild symptoms relieved by lubricants CTCAE: E10364 Grade 3 dry eye AE MW, YH CTCAE: E10366 a dry eye AE that has a decrease in visual acuity (<20/40); limiting self care activities of daily living Grade 3 keratitis AE CTCAE: E10399 MW, YH a keratitis AE that has a decline in vision (worse than 20/40 but better than 20/200); limiting self care activities of daily living Grade 4 keratitis AE MW, YH a keratitis AE that has perforation or blindness (20/200 or worse) in the affected eye CTCAE: E10400 Grade 4 night blindness AE a night blindness AE that has blindness (20/200 or worse) in the affected eye CTCAE: E10405 MW, YH Grade 2 optic nerve disorder AE MW, YH an optic nerve disorder AE that has limiting vision of the affected eye (20/40 or better) CTCAE: E10408 Grade 3 optic nerve disorder AE an optic nerve disorder AE that has limiting vision in the affected eye (worse than 20/40 but better than 20/200) CTCAE: E10409 MW, YH Grade 4 optic nerve disorder AE MW, YH an optic nerve disorder AE that has blindness (20/200 or worse) in the affected eye CTCAE: E10410 Grade 2 retinal tear AE a retinal tear AE where laser therapy or pneumopexy indicated CTCAE: E10426 MW, YH Grade 3 retinal tear AE a retinal tear AE where vitroretinal surgical repair indicated CTCAE: E10427 MW, YH Grade 4 retinal tear AE CTCAE: E10428 a retinal tear AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 2 retinal vascular disorder AE MW, YH a retinal vascular disorder AE where topical medication indicated CTCAE: E10430 Grade 3 retinal vascular disorder AE a retinal vascular disorder AE where intravitreal medication; operative intervention indicated MW, YH CTCAE: E10431 Grade 2 scleral disorder AE MW, YH a scleral disorder AE that is symptomatic, limiting instrumental activities of daily living; moderate decrease in visual acuity (20/40 or better) CTCAE: E10439 Grade 3 scleral disorder AE MW, YH a scleral disorder AE that is symptomatic, limiting self care activities of daily living; marked decrease in visual acuity (worse than 20/40) CTCAE: E10440 Grade 4 scleral disorder AE CTCAE: E10441 a scleral disorder AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 3 vitreous hemorrhage AE MW, YH CTCAE: E10450 a vitreous hemorrhage AE that has limiting self care activities of daily living; vitrectomy indicated Grade 4 vitreous hemorrhage AE CTCAE: E10451 a vitreous hemorrhage AE that has blindness (20/200 or worse) in the affected eye MW, YH Grade 3 anal necrosis AE MW, YH an anal necrosis AE where TPN or hospitalization indicated; radiologic, endoscopic, or operative intervention indicated CTCAE: E10483 Grade 2 anal stenosis AE CTCAE: E10492 an anal stenosis AE that is symptomatic; altered GI function MW, YH Grade 3 anal stenosis AE an anal stenosis AE that is symptomatic and severely altered GI function; non-emergent operative intervention indicated; TPN or hospitalization indicated MW, YH CTCAE: E10493 Grade 1 bloating AE a bloating AE that has no change in bowel function or oral intake CTCAE: E10509 MW, YH Grade 2 bloating AE MW, YH a bloating AE that is symptomatic, decreased oral intake; change in bowel function CTCAE: E10510 Grade 2 cecal hemorrhage AE MW, YH CTCAE: E10513 a cecal hemorrhage AE that has moderate symptoms; medical intervention or minor cauterization indicated Grade 3 cecal hemorrhage AE MW, YH CTCAE: E10514 a cecal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 2 colonic fistula AE CTCAE: E10529 a colonic fistula AE that is symptomatic; altered GI function MW, YH Grade 3 colonic fistula AE MW, YH CTCAE: E10530 a colonic fistula AE that has severely altered GI function; bowel rest, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 colonic hemorrhage AE CTCAE: E10536 a colonic hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 2 colonic obstruction AE CTCAE: E10541 a colonic obstruction AE that is symptomatic; altered GI function MW, YH Grade 2 colonic ulcer AE a colonic ulcer AE that is symptomatic; altered GI function MW, YH CTCAE: E10558 Grade 3 colonic ulcer AE CTCAE: E10559 a colonic ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling MW, YH Grade 2 duodenal fistula AE a duodenal fistula AE that is symptomatic; altered GI function MW, YH CTCAE: E10584 Grade 3 duodenal fistula AE a duodenal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH CTCAE: E10585 Grade 3 duodenal hemorrhage AE a duodenal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH CTCAE: E10591 Grade 2 duodenal obstruction AE a duodenal obstruction AE that is symptomatic; altered GI function CTCAE: E10596 MW, YH Grade 2 duodenal stenosis AE MW, YH a duodenal stenosis AE that is symptomatic; altered GI function CTCAE: E10607 Grade 3 duodenal stenosis AE CTCAE: E10608 a duodenal stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated MW, YH Grade 2 esophageal fistula AE an esophageal fistula AE that is symptomatic; altered GI function CTCAE: E10641 MW, YH Grade 3 esophageal fistula AE an esophageal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH CTCAE: E10642 Grade 3 esophageal hemorrhage AE MW, YH an esophageal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated CTCAE: E10648 Grade 3 esophageal necrosis AE an esophageal necrosis AE that has inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated MW, YH CTCAE: E10652 Grade 2 esophageal obstruction AE MW, YH an esophageal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living CTCAE: E10657 Grade 2 esophageal ulcer AE MW, YH CTCAE: E10678 an esophageal ulcer AE that is symptomatic; altered GI function; limiting instrumental activities of daily living Grade 3 esophageal ulcer AE an esophageal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care activities of daily living; disabling CTCAE: E10679 MW, YH Grade 3 esophageal varices hemorrhage AE CTCAE: E10684 an esophageal varices hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 2 gastric fistula AE CTCAE: E10702 a gastric fistula AE that is symptomatic; altered GI function MW, YH Grade 3 gastric fistula AE a gastric fistula AE that has severely altered GI function; bowel rest; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated MW, YH CTCAE: E10703 Grade 3 gastric necrosis AE a gastric necrosis AE that has inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated CTCAE: E10713 MW, YH Grade 2 gastric stenosis AE MW, YH a gastric stenosis AE that is symptomatic; altered GI function CTCAE: E10723 Grade 3 gastric stenosis AE CTCAE: E10724 a gastric stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated MW, YH Grade 2 gastrointestinal fistula AE a gastrointestinal fistula AE that is symptomatic; altered GI function CTCAE: E10751 MW, YH Grade 3 gastrointestinal fistula AE MW, YH a gastrointestinal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated CTCAE: E10752 Grade 1 gastroparesis AE a gastroparesis AE that has mild nausea, early satiety and bloating, able to maintain caloric intake on regular diet CTCAE: E10760 MW, YH Grade 2 gastroparesis AE MW, YH a gastroparesis AE that has moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention CTCAE: E10761 Grade 3 gastroparesis AE CTCAE: E10762 a gastroparesis AE that has weight loss; refractory to medical intervention; unable to maintain nutrition orally MW, YH Grade 2 ileal fistula AE an ileal fistula AE that is symptomatic; altered GI function MW, YH CTCAE: E10779 Grade 3 ileal fistula AE CTCAE: E10780 an ileal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 ileal hemorrhage AE CTCAE: E10786 MW, YH an ileal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 2 ileal obstruction AE MW, YH an ileal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living CTCAE: E10791 Grade 2 ileal stenosis AE an ileal stenosis AE that is symptomatic; altered GI function CTCAE: E10802 MW, YH Grade 3 ileal stenosis AE CTCAE: E10803 an ileal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated MW, YH Grade 2 ileal ulcer AE CTCAE: E10808 an ileal ulcer AE that is symptomatic; altered GI function MW, YH Grade 3 ileal ulcer AE MW, YH an ileal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling CTCAE: E10809 Grade 3 intra-abdominal hemorrhage AE CTCAE: E10819 an intra-abdominal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 2 jejunal fistula AE MW, YH a jejunal fistula AE that is symptomatic; altered GI function CTCAE: E10824 Grade 3 jejunal fistula AE CTCAE: E10825 a jejunal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated MW, YH Grade 3 jejunal hemorrhage AE MW, YH CTCAE: E10831 ajejunal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated Grade 2 jejunal obstruction AE CTCAE: E10836 a jejunal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH Grade 2 jejunal stenosis AE MW, YH a jejunal stenosis AE that is symptomatic; altered GI function CTCAE: E10847 Grade 3 jejunal stenosis AE MW, YH CTCAE: E10848 a jejunal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated Grade 2 jejunal ulcer AE a jejunal ulcer AE that is symptomatic; altered GI function CTCAE: E10853 MW, YH Grade 3 jejunal ulcer AE CTCAE: E10854 a jejunal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling MW, YH Grade 3 lower gastrointestinal hemorrhage AE CTCAE: E10864 a lower gastrointestinal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 2 malabsorption AE MW, YH a malabsorption AE where altered diet; oral intervention indicated CTCAE: E10868 Grade 3 malabsorption AE CTCAE: E10869 a malabsorption AE that has inability to aliment adequately; TPN indicated MW, YH Grade 2 obstruction gastric AE an obstruction gastric AE that is symptomatic; altered GI function; limiting instrumental activities of daily living MW, YH CTCAE: E10884 Grade 3 oral hemorrhage AE CTCAE: E10901 an oral hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 2 pancreatic duct stenosis AE CTCAE: E10910 MW, YH a pancreatic duct stenosis AE that is symptomatic; altered GI function Grade 3 pancreatic duct stenosis AE a pancreatic duct stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated CTCAE: E10911 MW, YH Grade 2 pancreatic fistula AE MW, YH CTCAE: E10916 a pancreatic fistula AE that is symptomatic; altered GI function Grade 3 pancreatic fistula AE MW, YH a pancreatic fistula AE that has severely altered GI function; tube feeding or TPN or hospitalization indicated; elective operative intervention indicated CTCAE: E10917 Grade 3 pancreatic hemorrhage AE MW, YH a pancreatic hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated CTCAE: E10923 Grade 3 pancreatic necrosis AE MW, YH CTCAE: E10927 a pancreatic necrosis AE where tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated Grade 3 peritoneal necrosis AE a peritoneal necrosis AE where tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated MW, YH CTCAE: E10940 Grade 1 proctitis AE CTCAE: E10944 MW, YH a proctitis AE that has rectal discomfort, intervention not indicated Grade 2 proctitis AE CTCAE: E10945 a proctitis AE that has symptoms (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental activities of daily living MW, YH Grade 3 proctitis AE MW, YH a proctitis AE that has severe symptoms; fecal urgency or stool incontinence; limiting self care activities of daily living CTCAE: E10946 Grade 2 rectal fistula AE a rectal fistula AE that is symptomatic; altered GI function CTCAE: E10951 MW, YH Grade 3 rectal fistula AE MW, YH CTCAE: E10952 a rectal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated Grade 2 rectal obstruction AE MW, YH a rectal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living CTCAE: E10973 Grade 2 rectal stenosis AE MW, YH a rectal stenosis AE that is symptomatic; altered GI function CTCAE: E10988 Grade 3 rectal stenosis AE MW, YH a rectal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated CTCAE: E10989 Grade 2 rectal ulcer AE CTCAE: E10994 a rectal ulcer AE that is symptomatic; altered GI function (e.g. altered dietary habits, vomiting, diarrhea) MW, YH Grade 3 rectal ulcer AE MW, YH CTCAE: E10995 a rectal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling Grade 3 retroperitoneal hemorrhage AE CTCAE: E11000 a retroperitoneal hemorrhage AE where transfusion, medical, radiologic, endoscopic, or elective operative intervention indicated MW, YH Grade 2 salivary gland fistula AE MW, YH a salivary gland fistula AE that is symptomatic; altered GI function; tube feeding indicated CTCAE: E11011 Grade 3 salivary gland fistula AE CTCAE: E11012 a salivary gland fistula AE that has severely altered GI function; hospitalization indicated; elective operative intervention indicated MW, YH Grade 1 tooth discoloration AE MW, YH a tooth discoloration AE that has surface stains CTCAE: E11053 Grade 1 edema limbs AE an edema limbs AE that has 5 - 10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection CTCAE: E11087 MW, YH Grade 2 edema limbs AE an edema limbs AE that has more than 10 to 30% inter-limb discrepancy in volume or circumference at point of greatest visible difference; readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental activities of daily living MW, YH CTCAE: E11088 Grade 3 edema limbs AE CTCAE: E11089 MW, YH an edema limbs AE that has more than 30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care activities of daily living Grade 1 edema trunk AE MW, YH CTCAE: E11091 an edema trunk AE that has swelling or obscuration of anatomic architecture on close inspection Grade 2 edema trunk AE MW, YH CTCAE: E11092 an edema trunk AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental activities of daily living Grade 3 edema trunk AE MW, YH CTCAE: E11093 an edema trunk AE that has gross deviation from normal anatomic contour; limiting self care activities of daily living Grade 2 neck edema AE A neck edema AE that has moderate neck edema; slight obliteration of anatomic landmarks; limiting instrumental activities of daily living MW, YH CTCAE: E11161 Grade 3 neck edema AE CTCAE: E11162 a neck edema AE that has generalized neck edema (e.g., difficulty in turning neck); limiting self care activities of daily living MW, YH Grade 2 bile duct stenosis AE MW, YH a bile duct stenosis AE that is symptomatic; altered GI function; IV fluids indicated <24 hrs CTCAE: E11175 Grade 3 bile duct stenosis AE CTCAE: E11176 MW, YH a bile duct stenosis AE that has severely altered GI function; radiologic, endoscopic or elective operative intervention indicated Grade 3 biliary fistula AE MW, YH CTCAE: E11181 a biliary fistula AE that has severely altered GI function; TPN indicated; endoscopic intervention indicated; elective operative intervention indicated Grade 3 gallbladder fistula AE a gallbladder fistula AE that is symptomatic or severely altered GI function; TPN indicated; radiologic, endoscopic or elective operative intervention indicated MW, YH CTCAE: E11192 Grade 2 gallbladder obstruction AE CTCAE: E11200 a gallbladder obstruction AE that is symptomatic; altered GI function; IV fluids indicated <24 hrs MW, YH Grade 3 gallbladder obstruction AE a gallbladder obstruction AE that is symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated CTCAE: E11201 MW, YH Grade 3 hepatic hemorrhage AE a hepatic hemorrhage AE where transfusion indicated MW, YH CTCAE: E11218 Grade 3 perforation bile duct AE MW, YH a perforation bile duct AE where radiologic, endoscopic or elective operative intervention indicated CTCAE: E11235 Grade 3 abdominal infection AE an abdominal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11283 Grade 1 anorectal infection AE MW, YH an anorectal infection AE that is localized; local intervention indicated CTCAE: E11287 Grade 2 anorectal infection AE CTCAE: E11288 an anorectal infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH Grade 3 anorectal infection AE MW, YH an anorectal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated CTCAE: E11289 Grade 3 appendicitis AE an appendicitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11293 Grade 3 arteritis infective AE CTCAE: E11302 MW, YH an arteritis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 biliary tract infection AE MW, YH a biliary tract infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11306 Grade 2 bladder infection AE CTCAE: E11310 MW, YH a bladder infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 3 bladder infection AE CTCAE: E11311 a bladder infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 bone infection AE a bone infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11315 Grade 2 bronchial infection AE MW, YH a bronchial infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11324 Grade 3 bronchial infection AE a bronchial infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated CTCAE: E11325 MW, YH Grade 3 cecal infection AE CTCAE: E11334 a cecal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 2 cervicitis infection AE CTCAE: E11338 MW, YH a cervicitis infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 cervicitis infection AE MW, YH a cervicitis infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11339 Grade 2 conjunctivitis infective AE a conjunctivitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11343 MW, YH Grade 3 conjunctivitis infective AE a conjunctivitis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11344 MW, YH Grade 2 corneal infection AE CTCAE: E11348 a corneal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 3 corneal infection AE MW, YH CTCAE: E11349 a corneal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 cranial nerve infection AE a cranial nerve infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11353 MW, YH Grade 2 duodenal infection AE CTCAE: E11361 a duodenal infection AE that has moderate symptoms; medical intervention indicated (e.g., oral antibiotics) MW, YH Grade 3 duodenal infection AE MW, YH CTCAE: E11362 a duodenal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 encephalitis infection AE MW, YH CTCAE: E11366 an encephalitis infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities Grade 3 encephalomyelitis infection AE MW, YH an encephalomyelitis infection AE when IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11370 Grade 3 endocarditis infective AE an endocarditis infective AE when IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11374 Grade 4 endophthalmitis AE CTCAE: E11380 an endophthalmitis AE that has blindness (20/200 or worse) MW, YH Grade 2 enterocolitis infectious AE MW, YH an enterocolitis infectious AE that has the passage of more than 3 unformed stools per 24 hrs or duration of illness longer than 48 hrs; moderate abdominal pain CTCAE: E11382 Grade 3 enterocolitis infectious AE CTCAE: E11383 an enterocolitis infectious AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated MW, YH Grade 2 esophageal infection AE MW, YH CTCAE: E11387 an esophageal infection AE where local intervention indicated (e.g., oral antibiotic, antifungal, antiviral) Grade 3 esophageal infection AE MW, YH an esophageal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11388 Grade 2 eye infection AE MW, YH CTCAE: E11392 an eye infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 eye infection AE an eye infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11393 MW, YH Grade 4 eye infection AE MW, YH an eye infection AE that has life-threatening consequences; urgent intervention indicated; enucleation CTCAE: E11394 Grade 3 gallbladder infection AE a gallbladder infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH CTCAE: E11397 Grade 1 gum infection AE MW, YH a gum infection AE where local therapy indicated (swish and swallow) CTCAE: E11401 Grade 2 gum infection AE MW, YH a gum infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11402 Grade 3 gum infection AE a gum infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11403 MW, YH Grade 3 hepatic infection AE CTCAE: E11407 MW, YH a hepatic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 2 infective myositis AE MW, YH a infective myositis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11422 Grade 3 infective myositis AE MW, YH CTCAE: E11423 a infective myositis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 2 joint infection AE a joint infection AE that is localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); needle aspiration indicated (single or multiple) CTCAE: E11427 MW, YH Grade 3 joint infection AE MW, YH a joint infection AE where arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage) CTCAE: E11428 Grade 3 kidney infection AE a kidney infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated CTCAE: E11432 MW, YH Grade 1 lip infection AE a lip infection AE that is localized, local intervention indicated MW, YH CTCAE: E11441 Grade 2 lip infection AE a lip infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11442 MW, YH Grade 3 lip infection AE CTCAE: E11443 a lip infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 2 lymph gland infection AE MW, YH a lymph gland infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11450 Grade 3 lymph gland infection AE CTCAE: E11451 a lymph gland infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 3 mediastinal infection AE MW, YH a mediastinal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11455 Grade 1 mucosal infection AE CTCAE: E11463 MW, YH a mucosal infection AE that is localized, local intervention indicated Grade 2 mucosal infection AE a mucosal infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH CTCAE: E11464 Grade 3 mucosal infection AE a mucosal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11465 MW, YH Grade 1 nail infection AE MW, YH CTCAE: E11469 a nail infection AE that is localized, local intervention indicated Grade 2 nail infection AE a nail infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11470 MW, YH Grade 3 nail infection AE a nail infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11471 Grade 2 otitis externa AE CTCAE: E11473 an otitis externa AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH Grade 3 otitis externa AE an otitis externa AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11474 MW, YH Grade 2 ovarian infection AE MW, YH an ovarian infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11483 Grade 3 ovarian infection AE an ovarian infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11484 MW, YH Grade 3 pancreas infection AE MW, YH a pancreas infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11488 Grade 1 paronychia AE a paronychia AE that has nail fold edema or erythema; disruption of the cuticle CTCAE: E11498 MW, YH Grade 2 paronychia AE CTCAE: E11499 a paronychia AE where localized intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); nail fold edema or erythema with pain; associated with discharge or nail plate separation; limiting instrumental activities of daily living MW, YH Grade 3 paronychia AE a paronychia AE where surgical intervention or IV antibiotics indicated; limiting self care activities of daily living CTCAE: E11500 MW, YH Grade 2 pelvic infection AE MW, YH CTCAE: E11502 a pelvic infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 3 pelvic infection AE a pelvic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11503 MW, YH Grade 2 penile infection AE MW, YH CTCAE: E11507 a penile infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 penile infection AE CTCAE: E11508 a penile infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH Grade 2 periorbital infection AE MW, YH CTCAE: E11512 a periorbital infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 periorbital infection AE MW, YH CTCAE: E11513 a periorbital infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 2 peripheral nerve infection AE a peripheral nerve infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) MW, YH CTCAE: E11517 Grade 3 peripheral nerve infection AE MW, YH CTCAE: E11518 a peripheral nerve infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 3 peritoneal infection AE CTCAE: E11522 MW, YH a peritoneal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated Grade 2 phlebitis infective AE MW, YH a phlebitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11531 Grade 3 phlebitis infective AE a phlebitis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11532 MW, YH Grade 2 pleural infection AE MW, YH CTCAE: E11536 a pleural infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 pleural infection AE a pleural infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH CTCAE: E11537 Grade 2 prostate infection AE CTCAE: E11541 MW, YH a prostate infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) Grade 3 prostate infection AE CTCAE: E11542 a prostate infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 2 rhinitis infective AE MW, YH a rhinitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11549 Grade 2 salivary gland infection AE a salivary gland infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH CTCAE: E11551 Grade 3 salivary gland infection AE CTCAE: E11552 MW, YH a salivary gland infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 2 scrotal infection AE CTCAE: E11556 MW, YH a scrotal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 scrotal infection AE a scrotal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11557 MW, YH Grade 2 small intestine infection AE a small intestine infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH CTCAE: E11575 Grade 3 small intestine infection AE a small intestine infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11576 MW, YH Grade 3 splenic infection AE CTCAE: E11585 MW, YH a splenic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 1 stoma site infection AE CTCAE: E11589 a stoma site infection AE that is localized, local intervention indicated MW, YH Grade 2 stoma site infection AE a stoma site infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11590 MW, YH Grade 3 stoma site infection AE a stoma site infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated CTCAE: E11591 MW, YH Grade 2 tooth infection AE MW, YH a tooth infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11595 Grade 3 tooth infection AE MW, YH CTCAE: E11596 a tooth infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 2 upper respiratory infection AE an upper respiratory infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11605 MW, YH Grade 3 upper respiratory infection AE CTCAE: E11606 an upper respiratory infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 2 urethral infection AE MW, YH CTCAE: E11610 a urethral infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) Grade 3 urethral infection AE a urethral infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated MW, YH CTCAE: E11611 Grade 2 uterine infection AE MW, YH a uterine infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral) CTCAE: E11620 Grade 3 uterine infection AE a uterine infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated MW, YH CTCAE: E11621 Grade 1 vulval infection AE MW, YH CTCAE: E11630 a vulval infection AE that is localized, local intervention indicated Grade 2 vulval infection AE A vulval infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral) MW, YH CTCAE: E11631 Grade 3 vulval infection AE MW, YH CTCAE: E11632 a vulval infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated Grade 2 wound infection AE a wound infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral) CTCAE: E11636 MW, YH Grade 3 wound infection AE a wound infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated CTCAE: E11637 MW, YH Grade 1 ankle fracture AE an ankle fracture AE that is mild; non-surgical intervention indicated MW, YH CTCAE: E11641 Grade 2 ankle fracture AE MW, YH CTCAE: E11642 an ankle fracture AE that is limiting instrumental activities of daily living; operative intervention indicated Grade 3 ankle fracture AE an ankle fracture AE that is limiting self care activities of daily living; elective surgery indicated MW, YH CTCAE: E11643 Grade 3 aortic injury AE an aortic injury AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated MW, YH CTCAE: E11645 Grade 4 aortic injury AE an aortic injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated MW, YH CTCAE: E11646 Grade 2 arterial injury AE CTCAE: E11650 an arterial injury AE that is symptomatic (e.g., claudication); repair or revision not indicated MW, YH Grade 3 arterial injury AE an arterial injury AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated MW, YH CTCAE: E11651 Grade 4 arterial injury AE an arterial injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated MW, YH CTCAE: E11652 Grade 3 biliary anastomotic leak AE CTCAE: E11657 MW, YH a biliary anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 bladder anastomotic leak AE a bladder anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH CTCAE: E11663 Grade 3 esophageal anastomotic leak AE MW, YH CTCAE: E11684 an esophageal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 fallopian tube anastomotic leak AE MW, YH CTCAE: E11694 a fallopian tube anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 4 fallopian tube perforation AE MW, YH a fallopian tube perforation AE that has life-threatening consequences; urgent operative intervention indicated (e.g., organ resection) CTCAE: E11701 Grade 3 gastric anastomotic leak AE CTCAE: E11712 MW, YH a gastric anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 gastrointestinal anastomotic leak CTCAE: E11718 a gastrointestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 2 gastrointestinal stoma necrosis MW, YH a gastrointestinal stoma necrosis AE that is a superficial necrosis; intervention not indicated CTCAE: E11722 Grade 2 hip fracture AE CTCAE: E11727 MW, YH a hip fracture AE that has a hairline fracture; mild pain; limiting instrumental activities of daily living; non-surgical intervention indicated Grade 3 hip fracture AE MW, YH a hip fracture AE that has severe pain; hospitalization or intervention indicated for pain control (e.g., traction); operative intervention indicated CTCAE: E11728 Grade 4 hip fracture AE CTCAE: E11729 a hip fracture AE that has life-threatening consequences; symptoms associated with neurovascular compromise MW, YH Grade 3 injury to carotid artery AE MW, YH CTCAE: E11731 an injury to carotid artery AE that has severe symptoms; limiting self care activities of daily living (e.g., transient cerebral ischemia); repair or revision indicated Grade 3 injury to jugular vein AE CTCAE: E11738 an injury to jugular vein AE that is symptomatic limiting self care activities of daily living; disabling; repair or revision indicated MW, YH Grade 3 injury to superior vena cava AE CTCAE: E11744 MW, YH an injury to superior vena cava AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated Grade 4 injury to superior vena cava AE a injury to superior vena cava AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated MW, YH CTCAE: E11745 Grade 3 intestinal stoma leak AE MW, YH an intestinal stoma leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated CTCAE: E11756 Grade 3 intestinal stoma leak AE an intestinal stoma leak AE that has severe symptoms; IV fluids, tube feeding, or TPN indicated greater than or equal to 24 hrs; elective operative intervention indicated MW, YH CTCAE: E11761 Grade 1 intestinal stoma site bleeding AE an intestinal stoma site bleeding AE that has minimal bleeding identified on clinical exam; intervention not indicated MW, YH CTCAE: E11765 Grade 3 intestinal stoma site bleeding AE an intestinal stoma site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated CTCAE: E11767 MW, YH Grade 1 intraoperative arterial injury AE an intraoperative arterial injury AE where primary repair of injured organ/structure indicated CTCAE: E11771 MW, YH Grade 2 intraoperative arterial injury AE MW, YH an intraoperative arterial injury AE where partial resection of injured organ/structure indicated CTCAE: E11772 Grade 3 intraoperative arterial injury AE MW, YH an intraoperative arterial injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling CTCAE: E11773 Grade 1 intraoperative breast injury AE MW, YH CTCAE: E11777 an intraoperative breast injury AE where primary repair of injured organ/structure indicated Grade 2 intraoperative breast injury AE an intraoperative breast injury AE where partial resection of injured organ/structure indicated MW, YH CTCAE: E11778 Grade 3 intraoperative breast injury AE MW, YH CTCAE: E11779 an intraoperative breast injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling Grade 3 intraoperative cardiac injury AE an intraoperative cardiac injury AE where primary repair of injured organ/structure indicated MW, YH CTCAE: E11783 Grade 1 intraoperative ear injury AE CTCAE: E11787 MW, YH an intraoperative ear injury AE where primary repair of injured organ/structure indicated Grade 2 intraoperative ear injury AE CTCAE: E11788 MW, YH an intraoperative ear injury AE where partial resection of injured organ/structure indicated Grade 3 intraoperative ear injury AE an intraoperative ear injury AE where complete resection of injured organ/structure indicated; disabling (e.g., impaired hearing; impaired balance) MW, YH CTCAE: E11789 Grade 1 intraoperative endocrine injury AE an intraoperative endocrine injury AE where primary repair of injured organ/structure indicated MW, YH CTCAE: E11793 Grade 2 intraoperative endocrine injury AE an intraoperative endocrine injury AE where partial resection of injured organ/structure indicated CTCAE: E11794 MW, YH Grade 3 intraoperative endocrine injury AE MW, YH CTCAE: E11795 an intraoperative endocrine injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling Grade 1 intraoperative gastrointestinal injury AE MW, YH CTCAE: E11799 an intraoperative gastrointestinal injury AE where primary repair of injured organ/structure indicated Grade 2 intraoperative gastrointestinal injury AE MW, YH CTCAE: E11800 an intraoperative gastrointestinal injury AE where partial resection of injured organ/structure indicated Grade 3 intraoperative gastrointestinal injury AE CTCAE: E11801 MW, YH an intraoperative gastrointestinal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling Grade 1 lintraoperative head and neck injury AE CTCAE: E11805 a lintraoperative head and neck injury AE where primary repair of injured organ/structure indicated MW, YH Grade 2 lintraoperative head and neck injury AE a lintraoperative head and neck injury AE where partial resection of injured organ/structure indicated MW, YH CTCAE: E11806 Grade 3 lintraoperative head and neck injury AE CTCAE: E11807 a lintraoperative head and neck injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 1 intraoperative hepatobiliary injury AE an intraoperative hepatobiliary injury AE where primary repair of injured organ/structure indicated MW, YH CTCAE: E11815 Grade 2 intraoperative hepatobiliary injury AE CTCAE: E11816 an intraoperative hepatobiliary injury AE where partial resection of injured organ/structure indicated MW, YH Grade 3 intraoperative hepatobiliary injury AE MW, YH CTCAE: E11817 an intraoperative hepatobiliary injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling Grade 1 intraoperative musculoskeletal injury AE MW, YH CTCAE: E11821 an intraoperative musculoskeletal injury AE where primary repair of injured organ/structure indicated Grade 2 intraoperative musculoskeletal injury AE CTCAE: E11822 MW, YH an intraoperative musculoskeletal injury AE where partial resection of injured organ/structure indicated Grade 3 intraoperative musculoskeletal injury AE an intraoperative musculoskeletal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling CTCAE: E11823 MW, YH Grade 1 intraoperative neurological injury AE MW, YH CTCAE: E11827 an intraoperative neurological injury AE where primary repair of injured organ/structure indicated Grade 2 intraoperative neurological injury AE an intraoperative neurological injury AE where partial resection of injured organ/structure indicated CTCAE: E11828 MW, YH Grade 3 intraoperative neurological injury AE CTCAE: E11829 an intraoperative neurological injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 1 intraoperative ocular injury AE an intraoperative ocular injury AE where primary repair of injured organ/structure indicated MW, YH CTCAE: E11833 Grade 2 intraoperative ocular injury AE an intraoperative ocular injury AE where partial resection of injured organ/structure indicated CTCAE: E11834 MW, YH Grade 3 intraoperative ocular injury AE CTCAE: E11835 an intraoperative ocular injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH Grade 1 intraoperative renal injury AE CTCAE: E11839 MW, YH an intraoperative renal injury AE where primary repair of injured organ/structure indicated Grade 2 intraoperative renal injury AE an intraoperative renal injury AE where partial resection of injured organ/structure indicated MW, YH CTCAE: E11840 Grade 3 intraoperative renal injury AE an intraoperative renal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling CTCAE: E11841 MW, YH Grade 1 intraoperative reproductive tract injury AE an intraoperative reproductive tract injury AE where primary repair of injured organ/structure indicated MW, YH CTCAE: E11845 Grade 2 intraoperative reproductive tract injury AE an intraoperative reproductive tract injury AE where partial resection of injured organ/structure indicated CTCAE: E11846 MW, YH Grade 3 intraoperative reproductive tract injury AE MW, YH an intraoperative reproductive tract injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling CTCAE: E11847 Grade 1 intraoperative respiratory injury AE an intraoperative respiratory injury AE where primary repair of injured organ/structure indicated CTCAE: E11851 MW, YH Grade 2 intraoperative respiratory injury AE CTCAE: E11852 MW, YH an intraoperative respiratory injury AE where partial resection of injured organ/structure indicated Grade 3 intraoperative respiratory injury AE CTCAE: E11853 MW, YH an intraoperative respiratory injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling Grade 1 intraoperative skin injury AE an intraoperative skin injury AE where primary repair of injured organ/structure indicated CTCAE: E11857 MW, YH Grade 2 intraoperative skin injury AE CTCAE: E11858 an intraoperative skin injury AE where partial resection of injured organ/structure indicated MW, YH Grade 3 intraoperative skin injury AE CTCAE: E11859 MW, YH an intraoperative skin injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling Grade 2 intraoperative splenic injury AE CTCAE: E11863 MW, YH an intraoperative splenic injury AE where primary repair of injured organ/structure indicated Grade 3 intraoperative splenic injury AE an intraoperative splenic injury AE where resection or reconstruction of injured organ/structure indicated; disabling MW, YH CTCAE: E11864 Grade 1 intraoperative urinary injury AE MW, YH CTCAE: E11868 an intraoperative urinary injury AE where primary repair of injured organ/structure indicated Grade 2 intraoperative urinary injury AE CTCAE: E11869 MW, YH an intraoperative urinary injury AE where partial resection of injured organ/structure indicated Grade 3 intraoperative urinary injury AE MW, YH CTCAE: E11870 an intraoperative urinary injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling Grade 1 intraoperative venous injury AE an intraoperative venous injury AE where primary repair of injured organ/structure indicated CTCAE: E11874 MW, YH Grade 2 intraoperative venous injury AE CTCAE: E11875 an intraoperative venous injury AE where partial resection of injured organ/structure indicated MW, YH Grade 3 intraoperative venous injury AE an intraoperative venous injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling MW, YH CTCAE: E11876 Grade 3 kidney anastomotic leak AE CTCAE: E11882 a kidney anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 large intestinal anastomotic leak AE CTCAE: E11888 a large intestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 pancreatic anastomotic leak AE a pancreatic anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated CTCAE: E11894 MW, YH Grade 3 pharyngeal anastomotic leak AE a pharyngeal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH CTCAE: E11900 Grade 2 postoperative hemorrhage AE CTCAE: E11905 a postoperative hemorrhage AE that has moderate bleeding; radiologic, endoscopic, or operative intervention indicated MW, YH Grade 3 postoperative hemorrhage AE MW, YH a postoperative hemorrhage AE where transfusion indicated of greather than or equal to 2 units (10 cc/kg for pediatrics) pRBCs beyond protocol specification; urgent radiologic, endoscopic, or operative intervention indicated CTCAE: E11906 Grade 2 postoperative thoracic procedure complication AE a postoperative thoracic procedure complication AE when the patient is extubated within 24 - 72 hrs postoperatively MW, YH CTCAE: E11910 Grade 3 postoperative thoracic procedure complication AE MW, YH CTCAE: E11911 a postoperative thoracic procedure complication AE when the patient is extubated more than 72 hrs postoperatively, but before tracheostomy indicated Grade 3 postoperative thoracic procedure complication AE CTCAE: E11912 MW, YH a postoperative thoracic procedure complication AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Grade 1 prolapse of intestinal stoma AE a prolapse of intestinal stoma AE that is asymptomatic; reducible MW, YH CTCAE: E11915 Grade 2 prolapse of intestinal stoma AE MW, YH CTCAE: E11916 a prolapse of intestinal stoma AE that is recurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental activities of daily living Grade 2 prolapse of urostomy AE a prolapse of urostomy AE treated with local care or maintenance; minor revision indicated MW, YH CTCAE: E11922 Grade 3 prolapse of urostomy AE CTCAE: E11923 a prolapse of urostomy AE that has dysfunctional stoma; elective operative intervention or major stomal revision indicated MW, YH Grade 1 radiation recall reaction (dermatologic) AE CTCAE: E11927 a radiation recall reaction (dermatologic) AE that has faint erythema or dry desquamation MW, YH Grade 2 radiation recall reaction (dermatologic) AE MW, YH CTCAE: E11928 a radiation recall reaction (dermatologic) AE that has moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema Grade 3 radiation recall reaction (dermatologic) AE CTCAE: E11929 MW, YH a radiation recall reaction (dermatologic) AE that has moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion Grade 4 radiation recall reaction (dermatologic) AE CTCAE: E11930 a radiation recall reaction (dermatologic) AE that has life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated MW, YH Grade 3 rectal anastomotic leak AE CTCAE: E11935 a rectal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 2 seroma AE a seroma AE that is symptomatic; simple aspiration indicated MW, YH CTCAE: E11940 Grade 3 seroma AE CTCAE: E11941 a seroma AE that is symptomatic, elective radiologic or operative intervention indicated MW, YH Grade 3 small intestinal anastomotic leak AE CTCAE: E11945 a small intestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 3 spermatic cord anastomotic leak AE MW, YH a spermatic cord anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated CTCAE: E11951 Grade 1 spinal fracture AE a spinal fracture AE that has mild back pain; nonprescription analgesics indicated MW, YH CTCAE: E11955 Grade 2 spinal fracture AE CTCAE: E11956 MW, YH a spinal fracture AE that has moderate back pain; prescription analgesics indicated; limiting instrumental activities of daily living Grade 3 spinal fracture AE a spinal fracture AE that has severe back pain; hospitalization or intervention indicated for pain control (e.g., vertebroplasty); limiting self care activities of daily living; disability MW, YH CTCAE: E11957 Grade 4 spinal fracture AE MW, YH CTCAE: E11958 a spinal fracture AE that has life-threatening consequences; symptoms associated with neurovascular compromise Grade 2 stenosis of gastrointestinal stoma AE a stenosis of gastrointestinal stoma AE that is symptomatic; IV fluids indicated <24 hrs; manual dilation at bedside MW, YH CTCAE: E11961 Grade 3 stenosis of gastrointestinal stoma AE CTCAE: E11962 MW, YH a stenosis of gastrointestinal stoma AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated Grade 3 tracheal hemorrhage AE CTCAE: E11972 a tracheal hemorrhage AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated MW, YH Grade 1 tracheal obstruction AE MW, YH CTCAE: E11976 a tracheal obstruction AE that has partial asymptomatic obstruction on examination (e.g., visual, radiologic or endoscopic) Grade 2 tracheal obstruction AE CTCAE: E11977 MW, YH a tracheal obstruction AE that is symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental activities of daily living Grade 3 tracheal obstruction AE CTCAE: E11978 MW, YH a tracheal obstruction AE that has stridor; radiologic or endoscopic intervention indicated (e.g., stent, laser); limiting self care activities of daily living Grade 4 tracheal obstruction AE CTCAE: E11979 a tracheal obstruction AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) MW, YH Grade 3 tracheostomy site bleeding AE a tracheostomy site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated CTCAE: E11984 MW, YH Grade 3 ureteric anastomotic leak AE an ureteric anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH CTCAE: E11990 Grade 3 urethral anastomotic leak CTCAE: E11996 MW, YH an urethral anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 urostomy leak AE MW, YH a urostomy leak AESevere symptoms; radiologic, endoscopic or elective operative intervention indicated CTCAE: E12002 Grade 2 urostomy obstruction AE a urostomy obstruction AE that is symptomatic; dilation or endoscopic repair or stent placement indicated MW, YH CTCAE: E12007 Grade 3 urostomy site bleeding AE MW, YH a urostomy site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated CTCAE: E12014 Grade 2 urostomy stenosis AE a urostomy stenosis AE that is symptomatic but no hydronephrosis, no sepsis or no renal dysfunction; dilation or endoscopic repair or stent placement indicated CTCAE: E12018 MW, YH Grade 3 urostomy stenosis AE MW, YH a urostomy stenosis AE that is symptomatic (e.g., hydronephrosis, or renal dysfunction); elective operative intervention indicated CTCAE: E12019 Grade 3 uterine anastomotic leak AE a uterine anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated CTCAE: E12025 MW, YH Grade 3 vaginal anastomotic leak AE CTCAE: E12037 MW, YH a vaginal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated Grade 3 vas deferens anastomotic leak AE CTCAE: E12043 a vas deferens anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated MW, YH Grade 2 vascular access complication AE CTCAE: E12047 MW, YH a vascular access complication AE that has device dislodgement, blockage, leak, or malposition; device replacement indicated Grade 3 vascular access complication AE MW, YH A vascular access complication AE that has deep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure) CTCAE: E12048 Grade 4 vascular access complication AE a vascular access complication AE that has embolic event including pulmonary embolism or life-threatening thrombus CTCAE: E12049 MW, YH Grade 3 blood antidiuretic hormone abnormal AE MW, YH CTCAE: E12095 a blood antidiuretic hormone abnormal AE where hospitalization indicated Grade 3 blood corticotrophin decreased AE a blood corticotrophin decreased AE where hospitalization indicated CTCAE: E12104 MW, YH Grade 1 carbon monoxide diffusing capacity decreased AE MW, YH a carbon monoxide diffusing capacity decreased AE that is 3 - 5 units below lower limit of normal; for follow-up, a decrease of 3 - 5 units (ml/min/mm Hg) below the baseline value CTCAE: E12113 Grade 2 carbon monoxide diffusing capacity decreased AE a carbon monoxide diffusing capacity decreased AE that is 6 - 8 units below lower limit of normal; for follow-up, an asymptomatic decrease of greater than 5 - 8 units (ml/min/mm Hg) below the baseline value CTCAE: E12114 MW, YH Grade 3 carbon monoxide diffusing capacity decreased AE CTCAE: E12115 MW, YH a carbon monoxide diffusing capacity decreased AE that is an asymptomatic decrease of greater than 8 units drop; greater than 5 units drop along with the presence of pulmonary symptoms (e.g. , greater than Grade 2 hypoxia or greater than Grade 2 or higher dyspnea) Grade 1 cardiac troponin I increased AE a cardiac troponin I increased AE that has levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer CTCAE: E12117 MW, YH Grade 3 cardiac troponin I increased AE MW, YH CTCAE: E12118 a cardiac troponin I increased AE that has levels consistent with myocardial infarction as defined by the manufacturer Grade 1 cardiac troponin T increased AE a cardiac troponin T increased AE that has levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer CTCAE: E12120 MW, YH Grade 3 cardiac troponin T increased AE MW, YH a cardiac troponin T increased AE that has levels consistent with myocardial infarction as defined by the manufacturer CTCAE: E12121 Grade 1 CD4 lymphocytes decreased AE MW, YH a CD4 lymphocytes decreased AE that is less than the lower limit of normal to 500/mm3 or 0.5 x 10e9 /L CTCAE: E12123 Grade 2 CD4 lymphocytes decreased AE CTCAE: E12124 MW, YH a CD4 lymphocytes decreased AE that is less than 500 - 200/mm3; less than 0.5 - 0.2 x 10e9 /L Grade 3 CD4 lymphocytes decreased AE MW, YH a CD4 lymphocytes decreased AE that is less than 200 - 50/mm3; less than 0.2 x 0.05 - 10e9 /L CTCAE: E12125 Grade 4 CD4 lymphocytes decreased AE CTCAE: E12126 MW, YH a CD4 lymphocytes decreased AE that is less than 50/mm3; less than 0.05 x 10e9 /L Grade 1 CPK increased AE MW, YH a CPK increased AE that is greater than the upper limit of normal to 2.5 times the upper limit of normal CTCAE: E12133 Grade 2 CPK increased AE CTCAE: E12134 a CPK increased AE that is greater than 2.5 -5 times the upper limit of normal MW, YH Grade 3 CPK increased AE CTCAE: E12135 a CPK increased AE that is greater than 5 to 10 times the upper limit of normal MW, YH Grade 4 CPK increased AE a CPK increased AE that is greater than 10 times the upper limit of normal CTCAE: E12136 MW, YH Grade 1 fibrinogen decreased AE a fibrinogen decreased AE that is less than 1.0 - 0.75 times the lower limit of normal or less than 25% decrease from baseline MW, YH CTCAE: E12152 Grade 2 fibrinogen decreased AE MW, YH a fibrinogen decreased AE that is less than 0.75 - 0.5 times the lower limit of normal or 25 - less than 50% decrease from baseline CTCAE: E12153 Grade 3 fibrinogen decreased AE a fibrinogen decreased AE that is less than 0.5 - 0.25 times the lower limit of normal or 50 - less than 75% decrease from baseline CTCAE: E12154 MW, YH Grade 4 fibrinogen decreased AE MW, YH a fibrinogen decreased AE that is less than 0.25 times the lower limit of normal or 75% decrease from baseline or absolute value less than 50 mg/dL CTCAE: E12155 Grade 1 haptoglobin decreased AE a haptoglobin decreased AE that is less than the lower limit of normal MW, YH CTCAE: E12170 Grade 1 pancreatic enzymes decreased AE CTCAE: E12204 a pancreatic enzymes decreased AE that is less than the lower limit of normal and asymptomatic MW, YH Grade 2 pancreatic enzymes decreased AE a pancreatic enzymes decreased AE that has an increase in stool frequency, bulk, or odor; steatorrhea MW, YH CTCAE: E12205 Grade 3 pancreatic enzymes decreased AE MW, YH CTCAE: E12206 a pancreatic enzymes decreased AE that has sequelae of absorption deficiency Grade 1 vital capacity abnormal AE CTCAE: E12221 MW, YH a vital capacity abnormal AE that has 90 - 75% of predicted value Grade 2 vital capacity abnormal AE CTCAE: E12222 MW, YH a vital capacity abnormal AE that is less than 75 - 50% of predicted value; limiting instrumental activities of daily living Grade 3 vital capacity abnormal AE a vital capacity abnormal AE that is less than 50% of predicted value; limiting self care activities of daily living CTCAE: E12223 MW, YH eclampsia AE 10014129 a seizure AE that occurs in a pregnant women that follows a preeclampsia. Such a seizure is not related to an existing brain condition. WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000899.htm WEB: https://en.wikipedia.org/wiki/Eclampsia JS, YH acute gastric mucosal lesion AE 10000753 AGML AE WEB: http://medmantic.com/wiki/Acute_Gastric_Mucosal_Lesion 急性胃黏膜损害 a gastric disorder AE that shows the body under stress, causing acute erosion, bleeding and ulcers, stomach or duodenal mucosa damage collectively. The main clinical manifestations include upper gastrointestinal bleeding and a small perforation. QL, YH bowel sounds increased AE 10048720 QL, YH a bowel sounds abnormal AE that shows an increased amount of bowel sounds. hyperactive bowel sounds AE 肠鸣音亢进 UMLS CUI: C0232694 WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm bowel sounds decreased AE UMLS CUI: C0232695 hypoactive bowel sounds AE WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm QL, YH 肠鸣音减弱 a bowel sounds abnormal AE that shows a decreased amount of bowel sounds. bowel sounds abnormal AE WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm UMLS CUI: C0159060 肠鸣音异常 QL, YH a gastrointestinal disorder AE that shows an abnormal amount of bowel sounds. cessation of bowel sounds AE 肠鸣音停止 a bowel sounds abnormal AE that shows an cesssation of any bowel sounds. 肠鸣音消失 WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm UMLS CUI: C0857330 QL, YH migraine with aura AE 10027607 WEB: http://www.mayoclinic.org/diseases-conditions/migraine-with-aura/basics/definition/con-20030404 a migraine AE which shows a migraine preceded or accompanied by sensory warning signs or symptoms, such as flashes of light, blind spots, or tingling in your hand or face. SJ, YH hyperacusia AE 10052526 WEB: https://en.wikipedia.org/wiki/Hyperacusis a hearing disorder AE with an abnormally disproportionate increase in the sensation of loudness in response to auditory stimuli of normal volume QL, YH 听觉过敏 lumbago AE a back pain AE that occurs at the low back WEB: https://en.wikipedia.org/wiki/Low_back_pain low back pain AE 腰痛 QL, YH 下背痛 monoplegia AE 10027926 a paralysis AE which occurs in a single limb, usually an arm WEB: http://en.wikipedia.org/wiki/Monoplegia SJ, YH motor dysfunction AE 10061296 a behavior and neurological AE which results in abnormal, disturbed or impaired functioning of a muscle, nerve, or center that affects or produces movement WEB: http://connection.ebscohost.com/c/reference-entries/23076155/motor-dysfunction SJ, YH musculoskeletal discomfort AE 10053156 a discomfort AE that occurs at the musculoskeletal level and results in musculoskeletal pain that affects the bones, muscles, ligaments, tendons, and nerves WEB: http://my.clevelandclinic.org/health/diseases_conditions/hic_musculoskeletal_pain musculoskeletal pain AE SJ, YH musculoskeletal disorder AE 10048592 SJ, YH a musculoskeletal and connective tissue AE which results in a disease or abnormal condition of the musculoskeletal system oliguria AE 10030302 SJ, YH WEB: http://c.merriam-webster.com/medlineplus/oliguria a urinary system AE which shows reduced excretion of urine procedural hypotension AE 10062300 WEB: http://www.mayoclinic.org/diseases-conditions/low-blood-pressure/basics/definition/con-20032298 a hypotension AE that happens during a medical procedure SJ, YH esophagus AE YH, MW a digestive system AE that occurs at esophagus 食道副作用 anus AE a digestive system AE that occurs at anus YH, MW duodenum AE a digestive system AE that occurs at duodenum MW, YH kidney area percussion pain AE a pain AE that shows the pain in the kidney area identified by a percussion procedure. 肾区叩击痛 QL, YH URL http://howshealth.com/kidney-pain-location-causes-symptoms-treatment/#percussion physical examination 10071941 a medical procedure by which a medical professional investigates the body of a patient for signs of disease. QL, YH WEB: http://www.webmd.com/a-to-z-guides/annual-physical-examinations WEB: https://en.wikipedia.org/wiki/Physical_examination percussion procedure 10051720 a physical test by which a surface is tapped to determine the underlying structure, and is used in clinical examinations to assess the condition of the thorax or abdomen. percussion test QL, YH WEB: https://en.wikipedia.org/wiki/Percussion_(medicine) cylindruria AE 10011730 10067534 管型尿 QL, YH a urine analysis result abnomal AE that shows cylindrical structures produced by the kidney and present in the urine. WEB: http://medical-dictionary.thefreedictionary.com/cylindruria urinary casts present AE hepatitis A AE 10019719 hepatitis A AE WEB: https://en.wikipedia.org/wiki/Hepatitis_A JX, YH a hepatitis AE that resutls in a hepatitis A viral infection. fasciitis AE 10016228 筋膜炎 WEB: https://en.wikipedia.org/wiki/Fasciitis JX, YH a connective tissue disorder AE that shows an inflammation of the fascia, the connective tissue surrounding muscles, blood vessels, and nerves. fibrosis tendinous AE 10016662 A tendon disorder AE that led to the formation of fibrous tissue in the tendon area WEB: http://study.com/academy/lesson/fibrous-connective-tissue-function-types.html JX, YH myofascitis AE 10052443 WEB: https://en.wikipedia.org/wiki/Fasciitis JX, YH 肌筋膜炎 a fasciitis AE that shows an inflammation of the muscle fascia, the connective tissue surrounding muscles. visual disturbance AE 10047543 an eye disorder AE that causes visual disturbance and interfere with normal sight. WEB: http://www.healthline.com/symptom/visual-disturbance JX, YH Grade 1 cognitive disturbance AE MW, YH a cognitive disturbance AE that has mild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated CTCAE: E12618 Grade 2 cognitive disturbance AE a cognitive disturbance AE that has moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated MW, YH CTCAE: E12619 Grade 3 cognitive disturbance AE MW, YH a cognitive disturbance AE that has severe cognitive disability; significant impairment of work/school/life performance CTCAE: E12620 abortion missed AE 10000230 JX, YH an abortion AE that results in a retention of dead products of conception in utero for more than 8 weeks. WEB: http://medical-dictionary.thefreedictionary.com/missed+abortion eye edema AE 10052139 an edema AE that has an outcome of swelling in the eye. JX, YH oral discomfort AE 10030973 JX, YH Oral discomfort AE is a discomfort AE that shows an uncomfortable feeling in the oral. 口腔不适 ovarian cyst AE 10033132 a female reproductive system AE that has an outcome of the presence of a fluid-filled sac within a patient's ovary. WEB: https://en.wikipedia.org/wiki/Ovarian_cyst JX, YH placental disorder AE 10035132 JX, YH WEB: https://en.wikipedia.org/wiki/Placental_disease a female reproductive system AE that occurs in the placental area. central nervous system inflammation AE WEB: https://en.wikipedia.org/wiki/Central_nervous_system_disease 中枢神经系统炎症 an inflammation AE that occurs at the central nervous system. JX, YH central nervous system lesion AE 10051290 a nervous system AE that has outcome of lesion in the area of central nervous system. JX, YH WEB: http://www.emedicinehealth.com/brain_lesions_lesions_on_the_brain/article_em.htm clumsiness AE 10009696 a behavioral and neurological AE is characterized by motor coordination problems with daily activities. WEB: http://www.healthline.com/symptom/clumsiness JX, YH dysgraphia AE 10058319 JX, YH WEB: https://en.wikipedia.org/wiki/Dysgraphia a behavioral and neurological AE is a deficiency in the ability to write, primarily handwriting, but also coherence. formication AE 10017062 a sensory neuropathy AE than is the medical term for a sensation that exactly resembles that of small insects crawling on (or under) the skin. WEB: https://en.wikipedia.org/wiki/Formication JX, YH hemiparesis AE 10019465 a paresis AE that shows muscle weakness of the entire left or right side of the body. WEB: https://en.wikipedia.org/wiki/Hemiparesis JX, YH 轻偏瘫 immunoglobulin increased AE JX, YH WEB: http://www.webmd.com/a-to-z-guides/immunoglobulins an immunology and allergy investigation result abnormal AE that results in an increased level of an immunoglobulin. micturition disorder AE 10027561 a urinary system AE that shows abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE. JX, YH WEB: http://sideeffects.embl.de/se/C0042035/pt muscle contractions involuntary AE 10028293 JX, YH a muscle twitch AE that has an outcome of contractions involuntary of muscle. 肌肉不自觉收缩 myelopathy AE 10028570 WEB: https://en.wikipedia.org/wiki/Myelopathy 脊髓病 a nervous system AE that describes any neurologic deficit related to the spinal cord. JX, YH optic neuritis retrobulbar AE 10030945 球后视神经炎 a optic neuritis AE that has outcome of optic neuritis in retrobulbar. JX, YH WEB: https://en.wikipedia.org/wiki/Optic_neuritis scotoma AE 10039729 暗点 WEB: https://en.wikipedia.org/wiki/Scotoma a eye AE that is an area of partial alteration in the field of vision consisting of a partially diminished or entirely degenerated visual acuity that is surrounded by a field of normal – or relatively well-preserved – vision. JX, YH autoimmune thyroiditis AE 10049046 https://en.wikipedia.org/wiki/Autoimmune_thyroiditis A thyroiditis AE where the body interprets the thyroid glands and its hormone products T3, T4 and TSH as threats, therefore producing special antibodies that target the thyroid’s cells, thereby destroying it. JX, YH 自我免疫性甲状腺炎 colitis ulcerative AE 10009900 ulcerative colitis AE 溃疡性结肠炎 JX, YH WEB: http://www.webmd.com/ibd-crohns-disease/ulcerative-colitis/ulcerative-colitis-topic-overview a colitis AE that is a disease that causes inflammation and sores (ulcers) in the lining of the large intestine. feces pale AE 10016102 an abnormal stool AE that shows pale or clay-colored stool. faeces pale AE WEB: http://www.healthline.com/symptom/pale-stools 大便苍白 JX, YH lymphoma AE 10025310 JX, YH WEB: https://en.wikipedia.org/wiki/Lymphoma 淋巴瘤 a tumor AE that is a group of blood cell tumors that develop from lymphatic cells. monoparesis AE 10027925 a paresis AE that affects a single limb, usually an arm. 单肢轻瘫 WEB: https://en.wikipedia.org/wiki/Monoplegia JX, YH ophthalmoplegia AE 10030875 a eye AE that refers to weakness (-paresis) or paralysis (-plegia) of one or more extraocular muscles which are responsible for eye movements. WEB: https://en.wikipedia.org/wiki/Ophthalmoparesis 眼肌麻痹 JX, YH pupils unequal AE 10037538 瞳孔不等 JX, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003314.htm a eye AE that has outcome of slight differences in pupil size. quadriplegia AE 10037714 quadriplegia AE is paralysis caused by illness or injury that results in the partial or total loss of use of all four limbs and torso. Tetraplegia JX, YH WEB: https://en.wikipedia.org/wiki/Tetraplegia 四肢麻痹 pleocytosis AE 10035551 a CSF white blood cell count increased AE with more than the normal number of lymphocytes in cerebrospinal fluid (CSF). JX, YH 脑脊液细胞增多 performance status decreased AE 10048919 WEB: https://en.wikipedia.org/wiki/Performance_status 体能下降 JX, YH a behavior and neurological AE that shows an decreased preformance skin mass AE 10067868 a skin AS that shows a mass at the skin. JX, YH skin tumor AE feces discolored AE 10016100 an abnormal stool AE that shows an abnomal color in the feces. faeces discoloured AE WEB: http://www.buzzle.com/articles/stool-colors-and-what-they-mean.html JX, YH ultrasound scan abnormal AE 10061606 JX, YH an investigation result abnormal AE that shows an abnormal ultrasound scan result. WEB: http://www.nhs.uk/conditions/ultrasound-scan/Pages/Introduction.aspx injection site discharge AE 10065600 JX, YH an injection site AE that shows some substance release from an injection site. axillary mass AE 10049021 JX, YH a tumor AE that has an outcome of the presense of a mass that arises from the axillary. 腋窝肿块 WEB: http://www.rightdiagnosis.com/sym/axillary_mass.htm psychomotor retardation AE 10037213 motormental retardation AE psychomotor impairment AE JX, YH a behavioral and neurological AE that involves a slowing-down of thought and a reduction of physical movements in an individual. WEB: https://en.wikipedia.org/wiki/Psychomotor_retardation 精神运动性阻滞 injection site abscess AE 10022044 an abscess AE that occurs at an injection-site. Note that an abscess is a collection of pus that has built up within a tissue of the body. WEB: https://en.wikipedia.org/wiki/Abscess JX, YH injection site ulcer AE 10022105 JX, YH WEB: https://en.wikipedia.org/wiki/Ulcer an ulcer AE that occurs at an injection-site. disseminated BCG infection AE 10069636 a viral infection AE that is caused by a disseminated Bacillus Calmette-Guerin bacterial infection. disseminated Bacillus Calmette-Guerin infection AE JX, YH tetraparesis AE JX, YH quadriparesis AE a paresis AE that shows a muscular weakness affecting all four extremities. WEB: http://www.medilexicon.com/medicaldictionary.php?t=91062 hypomenorrhea AE 10021032 WEB: https://en.wikipedia.org/wiki/Hypomenorrhea hypomenorrhoea AE 月经减少 QL, YH a menstrual disorder AE that shows an extremely light menstrual blood flow menorrhagia AE WEB: https://en.wikipedia.org/wiki/Menorrhagia a menstrual disorder AE that shows a menstrual period with abnormally heavy flow and falls under the larger category of abnormal uterine bleeding (AUB) hypermenorrhea AE QL, YH necrospermia AE 10074729 MP: MP_0009325 QL, YH WEB: https://en.wikipedia.org/wiki/Necrospermia a male reproductive system AE in which spermatozoa in seminal fluid are dead or motionless 死精 subfertility AE 10042391 WEB: https://en.wikipedia.org/wiki/Infertility JX, LW, YH MP: MP_0001921 a reproductive system AE that results in diminished ability to produce live offspring 生育能力下降 infertility AE 10021926 不孕不育 QL, YH WEB: http://www.mayoclinic.org/diseases-conditions/infertility/basics/definition/con-20034770 MP: MP_0001921 a reproductive system AE that results in an inability to conceive for at least one year after trying and having unprotected sex. low estrogen level AE 10015519 WEB: http://www.md-health.com/Low-Estrogen.html hypoestrogenism AE 性激素水平下降 estrogen deficiency AE QL, YH an endocrine investigation result abnormal AE that is characterized by a lower than normal level of estrogen, the primary sex hormone in women WEB: https://en.wikipedia.org/wiki/Hypoestrogenism dysfunctional uterine bleeding AE 10013908 QL, YH 功能性子宫出血 WEB: http://emedicine.medscape.com/article/257007-overview MESH: D008796 a hemorrhage AE that occurs at the uterus, but it is not related to menstruation. The irregular and unpredictable bleeding usually comes from a dysfunctional endometrium. testicular atrophy AE 10043298 睾丸萎缩 WEB: https://en.wikipedia.org/wiki/Testicular_atrophy QL, YH a testicular disorder AE that has a loss of testicular volume pure red cell aplasia AE red-cell aplasia, pure PRCA AE QL, YH WEB: http://emedicine.medscape.com/article/205695-overview MESH: D012010 an aplastic anemia AE that results in the suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. 纯红再障性贫血 paraplegia AE 10033892 WEB: https://en.wikipedia.org/wiki/Paraplegia YH, JX a paralysis AE that shows an impairment in motor or sensory function of the lower extremities. allergic cutaneous vasculitis AE QL, YH WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000874.htm DO: DOID_11450 a cutaneous vasculitis AE that results in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the kin. 皮肤变应性血管炎 melanoplakia AE SNOMEDCT: 84647002 a skin hyperpigmentation AE that shows the occurrence of pigmented patches on the tongue and buccal mucousmembranes. WEB: http://www.medilexicon.com/medicaldictionary.php?t=53725 皮肤黑斑病 QL, YH erythema nodosum AE 10015226 结节性红斑 an erythema AE that showns an erythematous eruption characterized by inflammatory nodules that are usually tender, multiple, and bilateral. Such a symptom is commonly associated with drug reactions or infection. WEB: https://en.wikipedia.org/wiki/Erythema_nodosum erythemanodosum AE QL, YH HPO: HP_0012219 MeSH: D004893 tonic spasm AE QL, YH WEB: http://medical-dictionary.thefreedictionary.com/tonic+spasm 强直性痉挛 a muscle spasm AE that occurs when the contraction of a spasm is sustained or continuing. Such a spasm is generally severe because is is often caused by diseases that affect the central nervous system or brain, such as tetanus, rabies, and cerebral palsy. polymenorrhea AE 10070501 月经频繁 a menstrual disorder AE that results in frequent menses amd the menstrual cycles lasting less than 21 days. HP: HP_0400007 QL, YH shortened menstrual period AE a menstrual disorder AE that shows an outcome of a shortened time of menstrual period 经期缩短 QL, YH short menstrual period AE WEB: http://www.everydayhealth.com/pms/short-periods.aspx prolonged menstrual period AE 经期延长 WEB: http://www.healthline.com/symptom/menstrual-irregularity QL, YH prolonged menstruation AE a menstrual disorder AE that shows an outcome of a prolonged duration of menstrual period neck stiffness AE 10028843 QL, YH musculoskeletal stiffness AE that occurs at the neck and is typically characterized by soreness and difficulty moving the neck, especially when trying to turn the head to the side. WEB: http://www.spine-health.com/conditions/neck-pain/stiff-neck-causes-symptoms-and-treatment 颈项强直 stiffness of the neck AE stiff neck AE premature ovarian failure AE DO: DOID_5426 a female reproductive system AE that occurs at the ovaries where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. WEB: https://www.nlm.nih.gov/medlineplus/prematureovarianfailure.html WEB: http://www.mayoclinic.org/diseases-conditions/premature-ovarian-failure/basics/definition/con-20028351 primary ovarian insufficiency AE QL, YH 卵巢早衰 skin erosion AE 10040840 QL, YH HP: HP_0200041 a skin adverse event that has an outcome of a discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed. arrest of hematopoiesis AE 造血功能障碍 QL, YH WEB: https://en.wikipedia.org/wiki/Haematopoiesis a hematopoietic system AE that has an outcome of an arrest of the formation of blood cellular components. acute arrest of hematopoiesis AE an arrest of hematopoiesis AE that occurs quickly 急性造血功能障碍 WEB: https://en.wikipedia.org/wiki/Haematopoiesis QL, YH scrotum ulcer AE SNOMEDCT: 9750001 QL, YH 阴囊破溃 an ulcer AE that occurs at the scrotum epidermolysis bullosa AE 10014989 WEB: http://www.mayoclinic.org/diseases-conditions/epidermolysis-bullosa/basics/definition/con-20032497 大疱性表皮坏死松解症 QL, YH a skin adverse event that inherited chronic noninflammatory skin disease manifested by vesicles, large bullae (blisters), and skin erosions which often result from trauma. epidermolysis bullosa type eruption AE uterine AE JX, YH a female reproductive system AE that occurs in the uterus WEB: https://en.wikipedia.org/wiki/Uterus endometritis AE 10014791 MW, YH a reproduction system inflammation AE that occurs in the endometrium, the inner lining of the uterus. 子宫内膜炎 WEB: https://en.wikipedia.org/wiki/Endometritis female reproduction system inflammation AE YH, JX an inflammation AE which occurs in the female reproduction system placentitis AE 10014791 WEB: https://en.wikipedia.org/wiki/Placenta a reproduction system inflammation AE that occurs in the placenta. 胎盘炎 JX, YH dystocia AE a female reproductive system AE that occurs when the baby does not exit the pelvis during childbirth due to being physically blocked, even though the uterus is contracting normally. JX, YH obstructed labour AE WEB: https://en.wikipedia.org/wiki/Obstructed_labour 难产 obstructed labor AE mycotic pneumonia AE WEB: https://en.wikipedia.org/wiki/Fungal_pneumonia 真菌性肺炎 JX, YH a pneumonia AE that is caused by a mycotic infection serositis AE 10058556 JX, YH WEB: https://en.wikipedia.org/wiki/Serositis an inflammation AE that refers to inflammation of the serous tissues of the body, the tissues lining the lungs (pleura), heart (pericardium), and the inner lining of the abdomen (peritoneum) and organs within. 浆膜炎 metritis AE 10066270 a female reproduction system inflammation AE that occurs in the wall of the uterus. 子宫炎 WEB: https://en.wikipedia.org/wiki/Metritis JX, YH purulent abscess AE JX, YH Note: based on the website: https://www.quora.com/What-is-a-purulent-abscess, it appears that the words purulent abscess are actually redundant. Purulent means pus. Abscess is a space or pocket in the body filled with pus. 化脓性脓肿 an abscess AE where the abscess is filled with pus. tetanus AE 10043376 破伤风 WEB: https://en.wikipedia.org/wiki/Tetanus lockjaw AE JX, YH a clostridial infection AE that results in muscle spasms. rectal abscess AE 10048947 JX, YH a abscess AE that shows a collection of pus found near the rectum. 直肠脓肿 WEB: http://www.webmd.com/a-to-z-guides/anal-abscess acute brucellosis AE 急性布氏杆菌病 JX, YH a brucellosis AE that shows an acute disease stage. WEB: https://en.wikipedia.org/wiki/Brucellosis supraclavicular lymphadenopathy AE 锁骨上淋巴结病 a lymphadenopathy AE where the lymphadenopathy occurs in the supraclavicular lymph nodes. WEB: https://en.wikipedia.org/wiki/Lymphadenopathy JX, YH body ache AE a pain AE that shows a person with generalized aches and pains in multiple areas of the body. JX, YH WEB: http://www.everydayhealth.com/symptom-checker/body-aches 体痛 pyelonephritis AE 10037596 肾盂肾炎 WEB: https://en.wikipedia.org/wiki/Pyelonephritis an inflammation AE that occurs in the kidney tissue, calyces, and renal pelvis. JX, YH brucellosis AE 布氏杆菌病 WEB: https://en.wikipedia.org/wiki/Brucellosis Crimean fever AE undulant fever AE Gibraltar fever AE a bacterial infection AE that is caused by the infection with Brucella, a Gram-negative bacterium. The infected animals can be human or a variety of mammal animals. rock fever AE Malta fever AE JX, YH Mediterranean fever AE Maltese fever AE Bang's disease AE parasitic infection AE WEB: https://en.wikipedia.org/wiki/Parasitic_disease YH, JX an infection AE that is caused by a parasite. intestinal helminthiasis AE 肠道蠕虫病 a parasitic infection AE that is caused by a heminth, i.e., a parasitic worm, in the location of intestine. JX, YH WEB: https://en.wikipedia.org/wiki/Helminthiasis liver infiltration AE a liver AE that has an outcome of the diffusion or accumulation of substances in the liver. PubMed: http://www.ncbi.nlm.nih.gov/pubmed/20806348 JX, YH 肝脏浸润 WEB: https://en.wikipedia.org/wiki/Infiltration_(medical) lymphoplasmacytic epididymitis AE 淋巴浆细胞性附睾炎 JX, YH WEB: https://en.wikipedia.org/wiki/Epididymitis an epididymitis AE where the epidiymis is filled up with lymphocytes and plasma cells. WEB: http://www.merriam-webster.com/medical/lymphoplasmacytic epididymitis AE a testicular disorder AE that results in a discomfort or pain of the epidiymis, a curved structure at the back of the testicle in which sperm matures and is stored. JX, YH WEB: https://en.wikipedia.org/wiki/Epididymitis disseminated histiocytic pneumonia AE 弥漫性组织细胞性肺炎 JX, YH PubMed: http://www.ncbi.nlm.nih.gov/pubmed/17882900 a pneumonia AE that results in the dissemination of histiocytes in the lung. WEB: https://en.wikipedia.org/wiki/Pneumonia lymphoplasmacytic myocarditis AE 淋巴浆细胞性心肌炎 a myocarditis AE where the heart muscle is filled with lymphocytes and plasma cells that are not normally seen. JX, YH WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001204/ immune reconstitution inflammatory syndrome AE 10065042 IRIS AE a syndrome AE in which the immune system begins to recover from an immunosuppression or AIDS, but then responds to a previously acquired opportunistic infection with an overwhelming inflammatory response that paradoxically makes the symptoms of infection worse. immune recovery syndrome AE WEB: https://en.wikipedia.org/wiki/Immune_reconstitution_inflammatory_syndrome JX, YH role in cellular and molecular interaction a role that exists in a cellular and molecular interaction NDF-RT: N0000000223 YH bile acid diarrhoea AE 10069703 YH WEB: http://patient.info/health/bile-acid-malabsorptiondiarrhoea-leaflet bile acid malabsorption AE WEB: https://en.wikipedia.org/wiki/Bile_acid_malabsorption WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002596/ a diarrhea AE that occurs when the bile acids are not reabsorbed into the bloodstream and enter the large bowel (colon), which causes abnormally high levels of water and salts in the large bowel and the formation of watery diarrhoea. nutritional disorder AE 营养失调 YH nutrition disorder AE WEB: http://www.who.int/topics/nutrition_disorders/en/ an adverse event that has an outcome of nutrition disorder, which can be caused by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods. malnutrition AE WEB: https://medlineplus.gov/ency/article/000404.htm a nutrional disorder AE that has an outcome of malnutrition, a condition resulting from insufficient nutrients in the body. 营养不良 YH small intestinal bacterial overgrowth AE BLS AE a gastrointestinal disorder AE that has an outcome of the presence of very large numbers of bacteria growing in the small intestine WEB: https://en.wikipedia.org/wiki/Blind_loop_syndrome WEB: https://medlineplus.gov/ency/article/000222.htm small bowel bacterial overgrowth AE SIBO AE BOS AE bacterial overgrowth syndrome AE YH blind loop syndrome AE moon face AE YH an edema face AE where the face has gradually swollen into a rounded shape WEB: http://www.webmd.com/a-to-z-guides/moon-facies activities of daily living impaired AE 10050954 ADL impaired AE a behavioral and neurological AE that has an outcome of impaired daily self care activities. WEB: https://en.wikipedia.org/wiki/Activities_of_daily_living KY, YH antibody test abnormal AE a hematology investigation result abnormal AE that is characterized by an abnomalty in the antibody level in the blood YH, KY antinuclear antibody positive AE YH, KY In most cases, a positive ANA test indicates that your immune system has launched a misdirected attack on your own tissue — in other words, an autoimmune reaction. But some people have positive ANA tests even when they're healthy. Ref: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566 ANA test abnormal AE URL: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566 an antibody test abnormal AE that shows positive antinuclear antibody, which often attack a person's own cell nucleus. autonomic nervous system imbalance AE 10003840 https://medlineplus.gov/autonomicnervoussystemdisorders.html#cat59 A nervous system AE which refers to an imbalance problem in the part of the nervous system that controls involuntary actions KY, YH CSF glucose increased AE 10050763 KY, YH https://en.wikipedia.org/wiki/CSF_glucose A CSF test result abnormal AE with high glucose levels in the cerebrospinal fluid. CSF immunoglobulin increased AE 10064338 KY, YH A CSF test result abnormal AE with high immunoglobin levels in the cerebrospinal fluid. https://labtestsonline.org/understanding/conditions/multiplesclerosis/start/2/ facial palsy AE 10016060 KY, YH http://www.facialpalsy.org.uk/about-facial-palsy/what-is-facial-palsy/1395/ A palsy AE with temporary or permanent weakness of the facial muscles on one or both sides of the face. intervertebral disc degeneration AE 10061246 KY, YH https://www.ncbi.nlm.nih.gov/pubmed/16915105 A bone AE that refers to structural failure in a disc and advanced signs of aging. lumbar puncture abnormal AE 10025000 A behavioral and neurological test abnormal AE result that has an abnormal outcome in lumbar puncture involving pain or numbness to the legs, lower back pain, headaches, risk of infection, or risk of bleeding in the spinal canal. KY, YH http://www.hopkinsmedicine.org/healthlibrary/test_procedures/neurological/lumbar_puncture_lp_92,p07666/ palsy AE A paralysis AE accompanied by involuntary tremors. 麻痹 KY, YH WEB: https://en.oxforddictionaries.com/definition/palsy WEB: https://en.wikipedia.org/wiki/Palsy neurological examination abnormal AE 10056832 KY, YH A behavioral and neurological test abnormal AE that involves an abnormal outcome in the series of simple questions and noninvasive tests in a neurological examination that provides crucial information about the nervous system. http://www.healthcommunities.com/brain-nerve-tests/what-is-a-neuro-exam.shtml paralysis flaccid AE 10033809 A paralysis AE characterized by extreme muscle weakness and loss of muscle tone. http://www.brainandspinalcord.org/flaccid-paralysis/ KY, YH 弛缓性麻痹 peroneal nerve palsy AE 10034701 https://medlineplus.gov/ency/article/000791.htm A paralysis AE on the peroneal nerve leading to loss of movement or sensation on the foot and leg and may lead to complete weakness or paralysis of the foot or leg. KY, YH optic hyperesthesia AE 光过敏 YH, Jiahao Wang WEB: http://medical-dictionary.thefreedictionary.com/optic+hyperesthesia A hyperaesthesia AE that occurs at the optic area, reflected by an abnormal sensitivity to light. asphyxia AE 10003497 10003502 窒息 An abnormal respiration AE that shows a severely deficient supply of oxygen to the body that arises from abnormal breathing. WEB: https://en.wikipedia.org/wiki/Asphyxia asphyxiation AE YH, Jiahao Wang myotonia AE 10061533 肌强直 WEB: https://en.wikipedia.org/wiki/Myotonia An muscle AE showing delayed relaxation (prolonged contraction) of the skeletal muscles after voluntary contraction or electrical stimulation YH, Jiahao Wang neck myotonia AE An myotonia AE that occurs in the neck. YH, Jiahao Wang WEB: https://en.wikipedia.org/wiki/Myotonia 颈项强直 abdominal distress AE 10000062 https://en.wikipedia.org/wiki/Distress_(medicine) NG, YH a behavioral and neurological AE that refers to any pain or discomfort in the abdomen. color blindness AE 10010016 https://en.wikipedia.org/wiki/Color_blindness NG, YH A blindness AE that refers to the reduced ability to distinguish between colors that are obvious to the rest of the population dystonia AE 10013983 http://www.webmd.com/brain/dystonia-causes-types-symptoms-and-treatments#1 a behavioral and neurological AE that is characterized by involuntary muscle contractions that cause abnormal posture and slow, repetitive movements NG, YH exciteness AE 10015627 a behavioral and neurological AE that is characterized by potentially impulsive or poorly controlled activity NG, YH lightheadedness AE 10024492 https://en.wikipedia.org/wiki/Lightheadedness a dizziness AE that creates a feeling of a light head caused by a temporary decrease in blood to the brain NG, YH mood disorder AE 10027952 mood problem https://en.wikipedia.org/wiki/Mood_disorder a psychiatric disorder AE that is characterized by an elevation or lowering of a person's mood NG, YH oligomenorrhea AE 10030294 a menstrual disorder AE that is characterized by infrequent menstrual periods NG, YH https://en.wikipedia.org/wiki/Oligomenorrhea ototoxicity AE 10033109 an ear AE that refers to ear poisoning resulting from exposure to drugs or chemicals that damage the inner ear https://en.wikipedia.org/wiki/Ototoxicity NG, YH periarteritis AE 10034462 an inflammation AE that leads to swelling around the blood vessel wall http://medical-dictionary.thefreedictionary.com/periarteritis NG, YH skin papilloma AE 10033722 https://en.wikipedia.org/wiki/Papilloma NG, YH a tumor AE that is benign and characterized by a small wart-like growth on the skin tingling AE 10043876 http://www.mayoclinic.org/symptom-checker/numbness-or-tingling-in-hands-adult/related-factors/itt-20009075 a paresthesia AE characterized by unusual prickling sensations in any part of the body NG, YH Grade 1 diarrhea AE CTCAE: E10573 MW, EO a diarrhea AE that has 4 stools per day over baseline; mild increase in ostomy output compared to baseline. Grade 2 diarrhea AE CTCAE: E10574 MW, EO a diarrhea AE that has increased of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline. Grade 3 diarrhea AE CTCAE: E10575 MW, EO a diarrhea AE that has increased of >=7 stools per day over baseline; incontinence; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL genetic epilepsy with febrile seizures plus AE https://www.ncbi.nlm.nih.gov/pubmed/25917466 BY, YH An epileptic seizure AE that is a complex autosomal dominant disorder usually caused by mutations in SCN1A (a voltage-gated sodium channel). One third of patients have febrile seizures only; two thirds have a variety of epilepsy syndromes, both focal and generalized. GEFS+ AE Grade 1 nausea AE CTCAE: E10879 MW, EO a nausea AE that has Loss of appetite without alteration in eating habits Grade 2 nausea AE CTCAE: E10880 MW, EO a nausea AE that has oral intake decreased without significant weight loss, dehydration or malnutrition Grade 3 nausea AE CTCAE: E10881 MW, EO a nausea AE that has inadequate oral caloric or fluid intake; tube feeding, TPN, or hospitalization indicated Bordetella pertussis infection AE A bacterial infection AE that is induced by the bacterium Bordetella pertussis, which causes an acute respiratory infection marked by severe, spasmodic coughing episodes during the paroxysmal phase. BY, YH https://www.ncbi.nlm.nih.gov/books/NBK7813/ infectious thyroiditis AE 10071250 https://en.wikipedia.org/wiki/Thyroiditis YH A thyroiditis AE that is caused by an infection with a pathogen (e.g., bacterium or virus). ulcer A disorder material entity that forms an open sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. https://en.wikipedia.org/wiki/Ulcer YH central nervous system toxicity AE 10071215 https://www.ncbi.nlm.nih.gov/pubmed/24275175 A neurotoxicity that occurs at the central nervous system. This type of neurotoxity manifests as altered thought content resulting in psychosis or confusion. BY, YH poliomyelitis AE 10036012 infantile paralysis AE http://www.who.int/biologicals/areas/vaccines/polio/en/ BY, YH A paralysis AE that results from infection with any one of the three related poliovirus types (referred to as types P1, P2, and P3) and that attacks the body's nervous system. polio AE graft rejection AE 10018650 BY, YH An immune system AE where a transplant recipient's immune system attacks the transplanted organ or tissue. https://medlineplus.gov/ency/article/000815.htm transplant rejection AE periarteritis nodosa AE 10034462 A vasculitis AE that affects medium-sized and small muscular arteries, resulting in microaneurysm formation, aneurysmal rupture with hemorrhage, thrombosis, and, consequently, organ ischemia or infarction. polyarteritis nodosa AE http://emedicine.medscape.com/article/330717-overview BY, YH panarteritis nodosa AE rigors AE 10039177 BY, YH http://patient.info/doctor/rigors An abnormal reflex AE characterized by episodes of shaking or exaggerated shivering which can occur with a high fever. lymphoproliferative disorder AE 10061232 An immunology AE in which cells of the lymphatic system grow excessively. It is a AE of the lymphoid cells and of cells from the reticuloendothelial system that usually occur in people with compromised immune systems. http://www.medicinenet.com/script/main/art.asp?articlekey=7859 BY. YH localized rash AE 10062705 BY, YH A rash AE where the rash is present on only one area of the body, which is usually caused by cellulitis, contat dermatitis, and poison ivy. http://www.everydayhealth.com/symptom-checker/localized-rash hereditary neuropathy with liability to pressure palsies AE 10069382 https://ghr.nlm.nih.gov/condition/hereditary-neuropathy-with-liability-to-pressure-palsies A neuropathy AE that is characterized by recurrent episodes of numbness, tingling, and loss of muscle function in the region associated with the affected nerve, usually an arm, hand, leg, or foot. HNPP AE BY, YH Rubella infection AE 10018206 three-day measles AE http://bodyandhealth.canada.com/channel/childhood-vaccinations/related-conditions/rubella BY, YH A viral infection AE that is caused by a Rubella virus. This contagious AE leads to symptoms that can include a low-grade fever, sore throat, and a red rash that starts on the face and spreads to the rest of the body. german measles AE vaccine-associated paralytic poliomyelitis AE 10076716 A poliomyelitis AE that is associated with oral poliovirus vaccine (OPV) that occurs among healthy OPV recipients and their contacts. It is clinically indistinguishable from poliomyelitis caused by wild-type polio virus, which causes temporary or permanent paralysis. VAPP AE https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321898/ BY, YH severe myoclonic epilepsy of infancy AE 10073677 https://www.dravetfoundation.org/what-is-dravet-syndrome/ SMEI AE BY, YH A seizure AE that is a rare, catastrophic, lifelong form of epilepsy that begins in the first year of life with frequent and/or prolonged seizures. dravet syndrome AE nontuberculous mycobacteria infection AE NTM infection AE http://www.lung.org/lung-health-and-diseases/lung-disease-lookup/nontuberculosis-mycobacteria/learn-about-ntm.html BY. YH A bacterial infection AE that is caused by exposure to environmental sources of nontuberculous mycobacteria (NTM), which leads to NTM entering the lungs, causing inflammation in the respiratory system. This AE can lead to progressive lung infection characterized by cough, shortness of breath, fatigue, and weight loss. X-linked agammaglobulinemia AE Congenital Agammaglobulinemia AE https://en.wikipedia.org/wiki/X-linked_agammaglobulinemia XLA AE http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/agammaglobulinemia-x-linked-autosomal-recessive/ BY. YH https://ghr.nlm.nih.gov/condition/x-linked-agammaglobulinemia Bruton’s Agammaglobulinemia AE An immunodeficiency AE that affects the immune system and results in the lack of the ability for the body to generate mature B cells, which manifests as a complete or near-complete lack of proteins called gamma globulins, including antibodies, in their bloodstream. This AE occurs almost exclusively in males. This AE also increases susceptibility to infections. Yellow Fever vaccine-associated viscerotropic disease AE 10069197 BY, YH https://www.cdc.gov/travel-training/local/HistoryEpidemiologyandVaccination/page27412.html A multi-organ failure AE that is associated with administration of a Yellow Fever vaccine. This happens when vaccine virus proliferates in multiple organs, causing multiple organ dysfunction syndrome or multiorgan failure and death. Grade 3 duodenal ulcer AE A duodenal ulcer AE that alters GI function and requiresTPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL. CTCAE: E10614 anal hemorrhage AE 10055226 NCIt: C78168 An anus AE that bleed from the anal region. CTCAE: E10470 Grade 2 anal hemorrhage AE An anal hemorrhage AE that has moderate symptoms; medical intervention or minor cauterization indicated. CTCAE: E10472 acute thyroiditis AE 10043780 https://en.wikipedia.org/wiki/Thyroiditis A thyroiditis AE where the thyroiditis inflammation has an acute process. YH Grade 3 anal hemorrhage AE An anal hemorrhage AE that has transfusion, radiologic, endoscopic, or elective operative intervention indicated. CTCAE: E10473 colonic stenosis AE 10010004 CTCAE: E10550 NCIt: C78243 A gastrointestinal disorder AE that has a narrowing of the lumen of the colon. Grade 2 colonic stenosis AE CTCAE: E10552 A colonic stenosis AE that altered GI function. Grade 3 colonic stenosis AE CTCAE: E10553 A colonic stenosis AE that alters GI function and requires tube feeding or hospitalization. esophageal perforation AE 10055472 CTCAE: E10665 An esophagus AE that has a rupture in the wall of the esophagus. NCIt: C50693 Grade 2 mucosal inflammation AE A mucosal inflammation AE that has moderate pain which is not interfering with oral intake but modified diet indicated. CTCAE: E10874 Grade 3 mucosal inflammation AE CTCAE: E10875 A mucosal inflammation AE that is interfering with oral intake. oral dysesthesia AE 10054520 A dysesthesia AE that has burning or tingling sensation on the lips, tongue or entire mouth. NCIt: C62545 CTCAE: E10894 Grade 3 Oral dysesthesia AE An oral dysesthesia AE that has disabling pain, requires tube feeding and TPN. CTCAE: E10897 Grade 2 Oral dysesthesia AE An oral dysesthesia AE that has m oderate pain and is interfering with oral intake. CTCAE: E10896 Grade 1 Oral dysesthesia AE An oral dysesthesia AE that has mild discomfort but is not interfering with oral intake. CTCAE: E10895 Grade 3 periodontal disease AE CTCAE: E10938 A periodontal disease AE that has spontaneous bleeding, severe bone loss with or without tooth loss and osteonecrosis of maxilla or mandible. Grade 2 periodontal disease AE CTCAE: E10937 A periodontal disease AE that has moderate gingival recession or gingivitis, multiple sites of bleeding on probing and moderate bone loss. Grade 1 periodontal disease AE A periodontal disease AE that has gingival recession or gingivitis, limited bleeding on probing and mild local bone loss. CTCAE: E10936 rectal necrosis AE 10065709 CTCAE: E10967 NCIt: C78585 A necrosis AE that there the ecrotic process occurring in the rectal wall. Grade 3 rectal necrosis AE A rectal necrosis AE that requires tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated. CTCAE: E10968 salivary duct inflammation AE 10056681 An inflammation AE that has inflammation of the salivary duct. CTCAE: E10470 NCIt: C78600 Grade 3 salivary duct inflammation AE CTCAE: E11006 A salivary duct inflammation AE that has acute salivary gland necrosis; severe secretion-induced symptoms (e.g., thick saliva/oral secretions or gagging); tube feeding or TPN indicated; limiting self care ADL; disabling Grade 2 salivary duct inflammation AE A salivary duct inflammation AE that has thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL CTCAE: E11005 Grade 1 salivary duct inflammation AE A salivary duct inflammation AE that has slightly thickened saliva; slightly altered taste (e.g., metallic) CTCAE: E11004 small intestinal mucositis AE 10065710 NCIt: C78613 An inflammation AE that has inflammation of the mucous membrane of the small intestine. CTCAE: E11015 Grade 3 small intestinal mucositis AE CTCAE: E11018 A small intestinal mucositis AE that has severe pain and is interfering with oral intake; tube feeding, TPN or hospitalization indicated. Grade 3 small intestine ulcer AE CTCAE: E11041 A small intestine ulcer AE that has altered GI function, requires TPN indicated. Elective operative or endoscopic intervention indicated; limiting self care ADL; disablingoperative intervention Grade 2 small intestine ulcer AE CTCAE: E11040 A small intestine ulcer AE that has altered GI function. tooth development disorder AE 10044030 CTCAE: E11048 A tooth disorder AE that has a pathological process of the teeth occurring during tooth development. NCIt: C35596 Grade 3 tooth development disorder AE CTCAE: E11051 A tooth development disorder AE that has maldevelopment with impairment not surgically correctable. Grade 2 tooth development disorder AE A tooth development disorder AE that has impairment correctable with oral surgery CTCAE: E11050 Grade 1 tooth development disorder AE A tooth development disorder AE that has hypoplasia of tooth or enamel. CTCAE: E11049 Grade 3 cecitis AE CTCAE: E11059 A digestive system AE that has abdominal pain, fever, change in bowel habits with ileus and peritoneal signs. chronic thyroiditis AE 10043781 https://en.wikipedia.org/wiki/Thyroiditis YH A thyroiditis AE where the thyroiditis inflammation has a chronic process. chronic fibrous thyroiditis AE 10043782 http://www.healthfrom.com/Disease/view-3435.html chronic thyroiditis wood AE invasive fibrous thyroiditis AE chronic sclerosing thyroiditis AE A chronic thyroiditis AE that shows a lot of dense fibrous tissue. Riedel's thyroiditis AE YH Riedel goiter AE fibrous chronic thyroiditis AE radition thyroiditis AE 10063885 https://en.wikipedia.org/wiki/Radiation-induced_thyroiditis YH An acute thyroiditis AE that shows a form of painful, acute thyroiditis resulting from radioactive therapy to treat hyperthyroidism or from radiation to treat head and neck cancer or lymphoma. Hashimoto's thyroiditis AE 10069432 https://en.wikipedia.org/wiki/Autoimmune_thyroiditis An autoimmune thyroiditis AE where the thyroid gland is gradually destroyed. chronic lymphocytic thyroiditis AE JX, YH Hashimoto's disease AE atrophic thyroiditis AE 10077172 https://link.springer.com/chapter/10.1007%2F978-1-60327-285-8_42 An autoimmune thyroiditis AE that shows an organ-specific autoimmune disease characterized by thyroid autoantibodies, functional hypothyroidism, and absence of goiter. YH postpartum thyroiditis AE https://en.wikipedia.org/wiki/Postpartum_thyroiditis A thyroiditis AE that occurs after pregnancy and may involve hyperthyroidism, hypothyroidism or the two sequentially. YH disorder A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf injection site a medical intervention site that is used for injection of a substance. YH, SS, ZX obsolete class has_specified_input has_specified_output