doid import.owl
type: Ontology
title: Human Disease Ontology
comment: DOID subset applied to OntONeo ontology.
comment: PERSON: Fernanda Farinelli This owl file represents the necessary entities of DOID that are reused in OntONeo Ontology. This file was created using Ontofox and some intermediary entities were not imported.

definition
type: AnnotationProperty

imported from
type: AnnotationProperty

DO MGI slim
type: AnnotationProperty
comment: DO_MGI_slim
sub property of: subset_property

DO rare slim
type: AnnotationProperty
comment: DO_rare_slim
sub property of: subset_property

NCIthesaurus
type: AnnotationProperty
comment: NCIt
sub property of: subset_property

subset_property
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

in_subset
type: AnnotationProperty

disease of metabolism
type: Class
subclass of: disease
id: DOID:0014667
database_cross_reference: ICD10CM:E88.9
database_cross_reference: ICD9CM:277.9
database_cross_reference: MSH:D008659
database_cross_reference: NCI:C3235
database_cross_reference: SNOMEDCT_US_2016_03_01:154733004
database_cross_reference: SNOMEDCT_US_2016_03_01:190961002
database_cross_reference: SNOMEDCT_US_2016_03_01:267456000
database_cross_reference: SNOMEDCT_US_2016_03_01:30390004
database_cross_reference: SNOMEDCT_US_2016_03_01:75934005
database_cross_reference: UMLS_CUI:C0025517
has_obo_namespace: disease_ontology
has_exact_synonym: metabolic disease
definition: A disease that involving errors in metabolic processes of building or degradation of molecules.
in_subset: NCIthesaurus

sinusitis
type: Class
subclass of: respiratory system disease
id: DOID:0050127
has_alternative_id: DOID:2052
has_alternative_id: DOID:9564
database_cross_reference: ICD10CM:J01
database_cross_reference: ICD10CM:J01.9
database_cross_reference: ICD10CM:J01.90
database_cross_reference: ICD9CM:461
database_cross_reference: ICD9CM:461.9
database_cross_reference: SNOMEDCT_US_2015_03_01:155498004
database_cross_reference: SNOMEDCT_US_2015_03_01:155501004
database_cross_reference: SNOMEDCT_US_2015_03_01:15805002
database_cross_reference: SNOMEDCT_US_2015_03_01:195649005
database_cross_reference: SNOMEDCT_US_2015_03_01:195653007
database_cross_reference: SNOMEDCT_US_2015_03_01:266378004
database_cross_reference: UMLS_CUI:C0149512
has_obo_namespace: disease_ontology
definition: A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip.
imported from: doid.owl
in_subset: NCIthesaurus

congenital adrenal insufficiency
type: Class
subclass of: adrenal gland disease
has_exact_synonym: ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL, PARTIAL OR COMPLETE
id: DOID:0050546
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:613743
has_exact_synonym: P450scc DEFICIENCY
has_obo_namespace: disease_ontology

chorioamnionitis
type: Class
subclass of: placenta disease
creation date: 2012-01-03T01:13:08Z
id: DOID:0050697
has_obo_namespace: disease_ontology
created by: lschriml
definition: A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection.

cardiomyopathy
type: Class
subclass of: heart disease
creation date: 2012-01-03T02:54:11Z
has_exact_synonym: Cardiomyopathies
id: DOID:0050700
database_cross_reference: ICD10CM:I42
database_cross_reference: ICD10CM:I42.9
database_cross_reference: ICD10CM:I51.5
database_cross_reference: ICD9CM:425
database_cross_reference: ICD9CM:425.9
database_cross_reference: MSH:D009202
comment: MSH:D009202 added from NeuroDevNet [WAK].
database_cross_reference: NCI:C34830
database_cross_reference: NCI:C53654
database_cross_reference: SNOMEDCT_US_2016_03_01:155351008
database_cross_reference: SNOMEDCT_US_2016_03_01:155353006
database_cross_reference: SNOMEDCT_US_2016_03_01:195035002
database_cross_reference: SNOMEDCT_US_2016_03_01:195037005
database_cross_reference: SNOMEDCT_US_2016_03_01:20072003
database_cross_reference: SNOMEDCT_US_2016_03_01:266244008
database_cross_reference: SNOMEDCT_US_2016_03_01:266301006
database_cross_reference: SNOMEDCT_US_2016_03_01:57809008
database_cross_reference: SNOMEDCT_US_2016_03_01:85898001
database_cross_reference: SNOMEDCT_US_2016_03_01:89461002
database_cross_reference: SNOMEDCT_US_2016_03_01:89600009
database_cross_reference: UMLS_CUI:C0033141
database_cross_reference: UMLS_CUI:C0036529
database_cross_reference: UMLS_CUI:C0878544
has_obo_namespace: disease_ontology
created by: lschriml
definition: A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.
in_subset: DO FlyBase slim

alcohol dependence
type: Class
subclass of: substance dependence
creation date: 2012-09-05T11:48:42Z
definition: A substance dependence that involves the continued use of alcohol despite problems related to use of the substance.
id: DOID:0050741
database_cross_reference: EFO:0003829
database_cross_reference: KEGG:05034
database_cross_reference: MSH:D010610
database_cross_reference: NCI:C93040
database_cross_reference: OMIM:103780
database_cross_reference: SNOMEDCT_US_2016_03_01:66590003
database_cross_reference: UMLS_CUI:C0001973
has_exact_synonym: alcoholism
has_obo_namespace: disease_ontology
created by: lschriml
in_subset: DO FlyBase slim

Axiom
annotated target: A substance dependence that involves the continued use of alcohol despite problems related to use of the substance.
database_cross_reference: url:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&version=16.07d&ns=NCI_Thesaurus&code=C93040&key=-1381701764&b=1&n=null
annotated source: alcohol dependence
annotated property: definition

nicotine dependence
type: Class
subclass of: substance dependence
creation date: 2012-09-05T11:48:42Z
id: DOID:0050742
database_cross_reference: EFO:0003768
database_cross_reference: ICD10CM:F17
database_cross_reference: ICD10CM:F17.2
database_cross_reference: ICD10CM:F17.20
database_cross_reference: MSH:D014029
database_cross_reference: NCI:C54203
database_cross_reference: OMIM:188890
database_cross_reference: SNOMEDCT_US_2016_03_01:56294008
database_cross_reference: UMLS_CUI:C0028043
has_obo_namespace: disease_ontology
created by: lschriml
has_exact_synonym: tobacco use disorder

Axiom
database_cross_reference: NSH:D014029
annotated target: tobacco use disorder
annotated source: nicotine dependence
annotated property: has_exact_synonym

congenital adrenal hyperplasia
type: Class
subclass of: disease of metabolism
creation date: 2013-12-04T12:52:02Z
id: DOID:0050811
database_cross_reference: ICD10CM:E25
database_cross_reference: ICD10CM:E25.9
database_cross_reference: ICD9CM:255.2
database_cross_reference: OMIM:201710
database_cross_reference: OMIM:201810
database_cross_reference: OMIM:201910
database_cross_reference: OMIM:202010
database_cross_reference: OMIM:202110
database_cross_reference: ORDO:418
database_cross_reference: SNOMEDCT_US_2016_03_01:154706003
database_cross_reference: SNOMEDCT_US_2016_03_01:190510000
database_cross_reference: SNOMEDCT_US_2016_03_01:190519004
database_cross_reference: SNOMEDCT_US_2016_03_01:267395000
database_cross_reference: UMLS_CUI:C0701163
comment: Xref MGI.
has_exact_synonym: adrenal hyperplasia 1
has_exact_synonym: congenital lipoid adrenal hyperplasia
has_obo_namespace: disease_ontology
has_exact_synonym: lipoid CAH
created by: lschriml
definition: A steroid inherited metabolic disorder that is characterized by adrenal insufficiency and variable degrees of hyper or hypo androgeny manifestations resulting from steroidogenic enzyme deficiency.
in_subset: DO MGI slim

endocardium disease
type: Class
subclass of: heart disease
creation date: 2014-02-12T01:53:42Z
id: DOID:0050825
has_obo_namespace: disease_ontology
created by: lschriml
definition: A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart.

tricuspid valve disease
type: Class
subclass of: heart valve disease
creation date: 2014-02-12T02:55:24Z
id: DOID:0050826
has_alternative_id: DOID:13834
database_cross_reference: ICD10CM:I07
database_cross_reference: ICD10CM:I07.9
database_cross_reference: ICD9CM:397.0
has_exact_synonym: RH. tricuspid valve disease
has_exact_synonym: Rheumatic disease of tricuspid valve (disorder)
has_exact_synonym: Rheumatic tricuspid valve disease NOS (disorder)
database_cross_reference: SNOMEDCT_US_2016_03_01:155289000
database_cross_reference: SNOMEDCT_US_2016_03_01:194745002
database_cross_reference: SNOMEDCT_US_2016_03_01:266282000
database_cross_reference: SNOMEDCT_US_2016_03_01:49699002
has_exact_synonym: Tricuspid disease
database_cross_reference: UMLS_CUI:C0264776
has_exact_synonym: disease of tricuspid valve
has_obo_namespace: disease_ontology
created by: lschriml
has_exact_synonym: rheumatic tricuspid valve disease

rheumatic heart disease
type: Class
subclass of: heart valve disease
creation date: 2014-02-12T03:03:38Z
id: DOID:0050827
has_obo_namespace: disease_ontology
created by: lschriml
definition: A heart valve disease that is characterized by repeated inflammation with fibrinous repair. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.It is caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage.

artery disease
type: Class
subclass of: vascular disease
creation date: 2014-02-12T03:08:35Z
id: DOID:0050828
has_obo_namespace: disease_ontology
created by: lschriml
definition: A vascular disease that is located_in an artery.

autoimmune disease of gastrointestinal tract
type: Class
subclass of: hypersensitivity reaction type II disease
id: DOID:0060031
has_obo_namespace: disease_ontology
definition: A hypersensitivity reaction type II disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract.

hypersensitivity reaction disease
type: Class
subclass of: immune system disease
id: DOID:0060056
has_obo_namespace: disease_ontology
definition: An immune system disease that is caused by abnormal immune responses.

gluten allergy
type: Class
subclass of: food allergy
id: DOID:0060057
has_exact_synonym: allergy to gluten
has_obo_namespace: disease_ontology
has_exact_synonym: gluten allergic reaction

inguinal hernia
type: Class
subclass of: gastrointestinal system disease
creation date: 2015-02-25T15:54:50Z
id: DOID:0060320
database_cross_reference: HP:0000023
database_cross_reference: ICD10CM:K40
database_cross_reference: ICD10CM:K40.90
database_cross_reference: ICD9CM:550
database_cross_reference: MSH:D006552
database_cross_reference: NCI:C34690
database_cross_reference: NCI:C34691
database_cross_reference: NCI:C34692
database_cross_reference: SNOMEDCT_US_2016_03_01:155738001
database_cross_reference: SNOMEDCT_US_2016_03_01:155741005
database_cross_reference: SNOMEDCT_US_2016_03_01:155744002
database_cross_reference: SNOMEDCT_US_2016_03_01:196800008
database_cross_reference: SNOMEDCT_US_2016_03_01:196822001
database_cross_reference: SNOMEDCT_US_2016_03_01:196827007
database_cross_reference: SNOMEDCT_US_2016_03_01:196828002
database_cross_reference: SNOMEDCT_US_2016_03_01:261478001
database_cross_reference: SNOMEDCT_US_2016_03_01:261480007
database_cross_reference: SNOMEDCT_US_2016_03_01:266440002
database_cross_reference: SNOMEDCT_US_2016_03_01:266508004
database_cross_reference: SNOMEDCT_US_2016_03_01:266509007
database_cross_reference: SNOMEDCT_US_2016_03_01:266510002
database_cross_reference: SNOMEDCT_US_2016_03_01:286968003
database_cross_reference: SNOMEDCT_US_2016_03_01:286969006
database_cross_reference: SNOMEDCT_US_2016_03_01:396232000
database_cross_reference: SNOMEDCT_US_2016_03_01:44297005
database_cross_reference: SNOMEDCT_US_2016_03_01:65626001
database_cross_reference: SNOMEDCT_US_2016_03_01:73147001
database_cross_reference: UMLS_CUI:C0019294
database_cross_reference: UMLS_CUI:C0019295
database_cross_reference: UMLS_CUI:C0019296
has_obo_namespace: disease_ontology
created by: emitraka
definition: An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

umbilical hernia
type: Class
subclass of: gastrointestinal system disease
creation date: 2015-02-25T15:58:35Z
id: DOID:0060321
database_cross_reference: HP:0001537
database_cross_reference: ICD10CM:Q79.2
database_cross_reference: ICD9CM:756.72
database_cross_reference: MSH:D006554
database_cross_reference: NCI:C98997
database_cross_reference: SNOMEDCT_US_2016_03_01:157007005
database_cross_reference: SNOMEDCT_US_2016_03_01:18735004
database_cross_reference: SNOMEDCT_US_2016_03_01:196854005
database_cross_reference: SNOMEDCT_US_2016_03_01:196872004
database_cross_reference: SNOMEDCT_US_2016_03_01:205516007
database_cross_reference: SNOMEDCT_US_2016_03_01:271017007
database_cross_reference: SNOMEDCT_US_2016_03_01:396347007
database_cross_reference: SNOMEDCT_US_2016_03_01:49324006
database_cross_reference: SNOMEDCT_US_2016_03_01:5867007
database_cross_reference: UMLS_CUI:C0795690
database_cross_reference: UMLS_CUI:C1306503
has_obo_namespace: disease_ontology
created by: emitraka
definition: A intestinal disease characterized by the protrusion by part of the intestine though an opening in the abdominal muscles.

transient neonatal diabetes mellitus
type: Class
subclass of: neonatal diabetes mellitus
creation date: 2015-03-12T16:59:58Z
id: DOID:0060334
database_cross_reference: ICD10CM:P70.2
database_cross_reference: OMIM:601410
database_cross_reference: OMIM:610374
database_cross_reference: OMIM:610582
database_cross_reference: ORDO:99886
has_obo_namespace: disease_ontology
created by: emitraka
definition: A neonatal diabetes mellitus characterized by hyperglycemia during the neonatal period that remits during infancy but recurs in later life in most patients.
imported from: doid.owl
in_subset: DO MGI slim
in_subset: DO rare slim

Zika fever
type: Class
subclass of: viral infectious disease
id: DOID:0060478
database_cross_reference: ICD10CM:A92.8
has_obo_namespace: disease_ontology
definition: A viral infectious disease that has_material_basis in Zika virus, which is transmitted_by Aedes aegypti mosquitoes.

chicken egg allergy
type: Class
subclass of: egg allergy
id: DOID:0060492
has_exact_synonym: Gallus gallus egg allergy
has_obo_namespace: disease_ontology
definition: An egg allergy triggered by Gallus gallus eggs.

shellfish allergy
type: Class
subclass of: food allergy
id: DOID:0060495
has_obo_namespace: disease_ontology
definition: A food allergy triggered by Crustacea or Mollusca.

respiratory allergy
type: Class
subclass of: allergic hypersensitivity disease
id: DOID:0060496
has_exact_synonym: airway allergy
has_obo_namespace: disease_ontology
definition: A hypersensitivity reaction type I disease located in the respiratory tract.

pollen allergy
type: Class
subclass of: respiratory allergy
id: DOID:0060497
has_obo_namespace: disease_ontology
definition: A respiratory allergy triggered by pollen.

Timothy grass allergy
type: Class
subclass of: pollen allergy
id: DOID:0060498
has_obo_namespace: disease_ontology
definition: A pollen allergy triggered by Phleum pratense pollen.

drug allergy
type: Class
subclass of: allergic hypersensitivity disease
id: DOID:0060500
has_obo_namespace: disease_ontology
definition: A hypersensitivity reaction type I disease triggered by a drug.

metal allergy
type: Class
subclass of: allergic hypersensitivity disease
id: DOID:0060501
has_obo_namespace: disease_ontology
definition: A hypersensitivity reaction type I disease triggered by a metal.

gastrointestinal allergy
type: Class
subclass of: allergic hypersensitivity disease
id: DOID:0060502
has_obo_namespace: disease_ontology
definition: A hypersensitivity reaction type I disease located in the gastrointestinal tract.

fruit allergy
type: Class
subclass of: food allergy
id: DOID:0060503
has_obo_namespace: disease_ontology
definition: A food allergy triggered by a plant fruit product.

apple allergy
type: Class
subclass of: fruit allergy
has_exact_synonym: DOID:0060504
id: DOID:0060504
has_exact_synonym: Malus domestica fruit allergy
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Malus domestica plant fruit food product.

apricot allergy
type: Class
subclass of: fruit allergy
id: DOID:0060505
has_exact_synonym: Prunus armeniaca fruit allergy
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Prunus armeniaca plant fruit food product.

cherry allergy
type: Class
subclass of: fruit allergy
id: DOID:0060506
has_exact_synonym: Prunus avium fruit allergy
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Prunus avium plant fruit food product.

Indian plum allergy
type: Class
subclass of: fruit allergy
id: DOID:0060507
has_exact_synonym: Ziziphus mauritiana fruit allergy
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Ziziphus mauritiana plant fruit food product.

orange allery
type: Class
subclass of: fruit allergy
has_exact_synonym: Citrus sinensis fruit allergy
id: DOID:0060508
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Citrus sinensis plant fruit food product.

melon allergy
type: Class
subclass of: fruit allergy
has_exact_synonym: Cucumis melo fruit allergy
id: DOID:0060509
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Cucumis melo plant fruit food product.

peach allergy
type: Class
subclass of: fruit allergy
id: DOID:0060510
has_exact_synonym: Prunus persica fruit allergy
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Prunus persica plant fruit food product.

plum allergy
type: Class
subclass of: fruit allergy
id: DOID:0060511
has_exact_synonym: Prunus domestica fruit allergy
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Prunus domestica plant fruit food product.

tomato allergy
type: Class
subclass of: fruit allergy
id: DOID:0060512
has_exact_synonym: Solanum lycopersicum fruit allergy
has_obo_namespace: disease_ontology
definition: A fruit allergy triggered by Solanum lycopersicum plant fruit food product.

fish allergy
type: Class
subclass of: food allergy
id: DOID:0060513
has_obo_namespace: disease_ontology
definition: A food allergy triggered by fish.

Atlantic cod allergy
type: Class
subclass of: fish allergy
id: DOID:0060514
has_exact_synonym: Gadus morhua fish allergy
has_obo_namespace: disease_ontology
definition: A fish allergy triggered by Gadus morhua.

Atlantic salmon allergy
type: Class
subclass of: fish allergy
id: DOID:0060515
has_exact_synonym: Salmo salar fish allergy
has_obo_namespace: disease_ontology
definition: A fish allergy triggered by Salmo salar.

carp allergy
type: Class
subclass of: fish allergy
has_exact_synonym: Cyprinus carpio fish allergy
id: DOID:0060516
has_obo_namespace: disease_ontology
definition: A fish allergy triggered by Cyprinus carpio.

zebrafish allergy
type: Class
subclass of: fish allergy
id: DOID:0060517
has_exact_synonym: Danio rerio allergy
has_obo_namespace: disease_ontology
definition: A fish allergy triggered by Danio rerio.

rainbow trout allergy
type: Class
subclass of: fish allergy
id: DOID:0060518
has_exact_synonym: Oncorhynchus mykiss allergy
has_obo_namespace: disease_ontology
definition: A fish allergy triggered by Oncorhynchus mykiss.

beta-lactam allergy
type: Class
subclass of: drug allergy
id: DOID:0060519
has_obo_namespace: disease_ontology
definition: A drug allergy triggered by a beta-lactam (β-lactam).

penicillin allergy
type: Class
subclass of: beta-lactam allergy
id: DOID:0060520
has_obo_namespace: disease_ontology
definition: A beta-lactam allergy triggered by penicillin.

cow milk allergy
type: Class
subclass of: milk allergy
has_exact_synonym: Bos taurus milk allergy
id: DOID:0060521
has_obo_namespace: disease_ontology
definition: A milk allergy triggered by Bos taurus milk.

goat milk allergy
type: Class
subclass of: milk allergy
has_exact_synonym: Capra hircus milk allergy
id: DOID:0060522
has_obo_namespace: disease_ontology
definition: A milk allergy triggered by Capra hircus milk.

mollusc allergy
type: Class
subclass of: shellfish allergy
id: DOID:0060523
has_obo_namespace: disease_ontology
definition: A shellfish allergy triggered by Mollusca.

crustacean allergy
type: Class
subclass of: shellfish allergy
id: DOID:0060524
has_obo_namespace: disease_ontology
definition: A shellfish allergy triggered by Crustacea.

brown shrimp allergy
type: Class
subclass of: crustacean allergy
id: DOID:0060525
has_exact_synonym: Farfantepenaeus aztecus allergy
has_obo_namespace: disease_ontology
definition: A crustacean allergy triggered by Farfantepenaeus aztecus.

green mud crab allergy
type: Class
subclass of: crustacean allergy
id: DOID:0060526
has_exact_synonym: Scylla paramamosain allergy
has_obo_namespace: disease_ontology
definition: A crustacean allergy triggered by Scylla paramamosain.

Indian prawn allergy
type: Class
subclass of: crustacean allergy
id: DOID:0060527
has_exact_synonym: Fenneropenaeus indicus allergy
has_obo_namespace: disease_ontology
definition: A crustacean allergy triggered by Fenneropenaeus indicus.

tiger prawn allergy
type: Class
subclass of: crustacean allergy
id: DOID:0060528
has_exact_synonym: Penaeus monodon allergy
has_obo_namespace: disease_ontology
definition: A crustacean allergy triggered by Penaeus monodon.

white shrimp allergy
type: Class
subclass of: crustacean allergy
id: DOID:0060529
has_exact_synonym: Litopenaeus vannamei allergy
has_obo_namespace: disease_ontology
definition: A crustacean allergy triggered by Litopenaeus vannamei.

snail allergy
type: Class
subclass of: mollusc allergy
id: DOID:0060530
has_obo_namespace: disease_ontology
definition: A mollusc allergy triggered by snails.

horned turban snail allergy
type: Class
subclass of: snail allergy
id: DOID:0060531
has_exact_synonym: Turbo cornutus allergy
has_obo_namespace: disease_ontology
definition: A snail allergy triggered by Turbo cornutus.

latex allergy
type: Class
subclass of: allergic hypersensitivity disease
id: DOID:0060532
has_obo_namespace: disease_ontology
definition: A hypersensitivity reaction type I disease triggered by latex.

bone disease
type: Class
subclass of: musculoskeletal system disease
id: DOID:0080001
has_alternative_id: DOID:1290
database_cross_reference: ICD10CM:M89.9
database_cross_reference: MSH:D001847
database_cross_reference: SNOMEDCT_US_2016_03_01:156814002
database_cross_reference: SNOMEDCT_US_2016_03_01:203524000
database_cross_reference: SNOMEDCT_US_2016_03_01:268126004
database_cross_reference: SNOMEDCT_US_2016_03_01:274145000
database_cross_reference: SNOMEDCT_US_2016_03_01:308147009
database_cross_reference: SNOMEDCT_US_2016_03_01:76069003
database_cross_reference: UMLS_CUI:C0005940
has_obo_namespace: disease_ontology
has_related_synonym: skeletal disease
definition: A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.

bone development disease
type: Class
subclass of: bone disease
id: DOID:0080006
has_obo_namespace: disease_ontology
definition: A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.

physical disorder
type: Class
subclass of: disease
id: DOID:0080015
has_obo_namespace: disease_ontology
definition: A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

endometritis
type: Class
subclass of: endometrial disease
id: DOID:1002
database_cross_reference: MSH:D004716
database_cross_reference: NCI:C26764
database_cross_reference: SNOMEDCT_US_2016_03_01:155975003
database_cross_reference: SNOMEDCT_US_2016_03_01:198192000
database_cross_reference: SNOMEDCT_US_2016_03_01:266652001
database_cross_reference: SNOMEDCT_US_2016_03_01:266653006
database_cross_reference: SNOMEDCT_US_2016_03_01:78623009
database_cross_reference: UMLS_CUI:C0014179
has_obo_namespace: disease_ontology

endometrial disease
type: Class
subclass of: uterine disease
id: DOID:1005
database_cross_reference: NCI:C3504
database_cross_reference: SNOMEDCT_US_2016_03_01:418632009
database_cross_reference: UMLS_CUI:C0151622
has_obo_namespace: disease_ontology

malignant hypertensive renal disease
type: Class
subclass of: renal hypertension
id: DOID:10177
database_cross_reference: SNOMEDCT_US_2015_03_01:65443008
database_cross_reference: UMLS_CUI:C0155593
has_obo_namespace: disease_ontology
imported from: doid.owl

diabetic peripheral angiopathy
type: Class
subclass of: type 2 diabetes mellitus
id: DOID:10182
database_cross_reference: ICD9CM:250.7
database_cross_reference: SNOMEDCT_US_2015_03_01:127014009
database_cross_reference: SNOMEDCT_US_2015_03_01:190354007
database_cross_reference: SNOMEDCT_US_2015_03_01:190361006
database_cross_reference: SNOMEDCT_US_2015_03_01:267383000
database_cross_reference: SNOMEDCT_US_2015_03_01:267473003
database_cross_reference: SNOMEDCT_US_2015_03_01:982001
database_cross_reference: UMLS_CUI:C0011871
has_obo_namespace: disease_ontology
imported from: doid.owl

bacterial infectious disease
type: Class
subclass of: disease
id: DOID:104
database_cross_reference: ICD10CM:A49
database_cross_reference: ICD10CM:A49.9
database_cross_reference: MSH:D001424
database_cross_reference: NCI:C2890
database_cross_reference: SNOMEDCT_US_2016_03_01:154318005
database_cross_reference: SNOMEDCT_US_2016_03_01:186470002
database_cross_reference: SNOMEDCT_US_2016_03_01:187347000
database_cross_reference: SNOMEDCT_US_2016_03_01:266182006
database_cross_reference: SNOMEDCT_US_2016_03_01:266187000
database_cross_reference: SNOMEDCT_US_2016_03_01:301811001
database_cross_reference: SNOMEDCT_US_2016_03_01:87628006
database_cross_reference: UMLS_CUI:C0004623
has_obo_namespace: disease_ontology
definition: A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.
in_subset: DO FlyBase slim

mild pre-eclampsia
type: Class
subclass of: pre-eclampsia
id: DOID:10590
database_cross_reference: ICD9CM:642.40
database_cross_reference: UMLS_CUI:C0156664
has_obo_namespace: disease_ontology
definition: A pre-eclampsia characterized by the presence of hypertension without evidence of end-organ damage, in a woman who was normotensive before 20 weeks' gestation.
imported from: doid.owl

pre-eclampsia
type: Class
subclass of: hypertension
id: DOID:10591
has_alternative_id: DOID:12684
database_cross_reference: ICD10CM:O13
database_cross_reference: ICD10CM:O14
database_cross_reference: ICD10CM:O14.9
database_cross_reference: ICD10CM:O14.90
database_cross_reference: MSH:D011225
database_cross_reference: MSH:D046110
database_cross_reference: NCI:C34943
database_cross_reference: NCI:C4371
database_cross_reference: NCI:C85021
database_cross_reference: OMIM:189800
database_cross_reference: OMIM:609402
database_cross_reference: OMIM:609403
database_cross_reference: OMIM:609404
database_cross_reference: OMIM:614592
database_cross_reference: ORDO:275555
database_cross_reference: SNOMEDCT_US_2015_03_01:15394000
database_cross_reference: SNOMEDCT_US_2015_03_01:156106005
database_cross_reference: SNOMEDCT_US_2015_03_01:156109003
database_cross_reference: SNOMEDCT_US_2015_03_01:156112000
database_cross_reference: SNOMEDCT_US_2015_03_01:198969004
database_cross_reference: SNOMEDCT_US_2015_03_01:198972006
database_cross_reference: SNOMEDCT_US_2015_03_01:198979002
database_cross_reference: SNOMEDCT_US_2015_03_01:199011002
database_cross_reference: SNOMEDCT_US_2015_03_01:237280005
database_cross_reference: SNOMEDCT_US_2015_03_01:267306006
database_cross_reference: SNOMEDCT_US_2015_03_01:267307002
database_cross_reference: SNOMEDCT_US_2015_03_01:288201007
database_cross_reference: SNOMEDCT_US_2015_03_01:30354006
database_cross_reference: SNOMEDCT_US_2015_03_01:308551004
database_cross_reference: SNOMEDCT_US_2015_03_01:398254007
database_cross_reference: SNOMEDCT_US_2015_03_01:46764007
database_cross_reference: SNOMEDCT_US_2015_03_01:48194001
database_cross_reference: SNOMEDCT_US_2015_03_01:6758009
database_cross_reference: UMLS_CUI:C0032914
database_cross_reference: UMLS_CUI:C0340274
has_obo_namespace: disease_ontology
has_exact_synonym: gestational hypertension
has_exact_synonym: hypertension induced by pregnancy
has_exact_synonym: pre-eclamptic toxaemia
has_exact_synonym: preeclampsia
has_exact_synonym: preeclampsia/eclampsia
has_exact_synonym: pregnancy associated hypertension
has_exact_synonym: pregnancy toxemia
has_exact_synonym: proteinuric hypertension of pregnancy
has_exact_synonym: toxaemia of pregnancy
definition: A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.
imported from: doid.owl
in_subset: DO MGI slim
in_subset: DO rare slim

glucose intolerance
type: Class
subclass of: hyperglycemia
id: DOID:10603
has_exact_synonym: Glucose: [intolerance] or [malabsorption]
database_cross_reference: ICD10CM:R73.09
database_cross_reference: MSH:D018149
has_exact_synonym: Malabsorption of glucose (disorder)
database_cross_reference: NCI:C34646
database_cross_reference: SNOMEDCT_US_2015_03_01:154720005
database_cross_reference: SNOMEDCT_US_2015_03_01:190752008
database_cross_reference: SNOMEDCT_US_2015_03_01:267426009
database_cross_reference: SNOMEDCT_US_2015_03_01:9414007
database_cross_reference: UMLS_CUI:C0271650
has_obo_namespace: disease_ontology
imported from: doid.owl

celiac disease
type: Class
subclass of: autoimmune disease of gastrointestinal tract
id: DOID:10608
database_cross_reference: EFO:0001060
database_cross_reference: ICD10CM:K90.0
database_cross_reference: ICD9CM:579.0
database_cross_reference: MSH:D002446
database_cross_reference: NCI:C26714
database_cross_reference: OMIM:212750
database_cross_reference: OMIM:607202
database_cross_reference: OMIM:609753
database_cross_reference: OMIM:609754
database_cross_reference: OMIM:609755
database_cross_reference: OMIM:611598
database_cross_reference: OMIM:612005
database_cross_reference: OMIM:612006
database_cross_reference: OMIM:612007
database_cross_reference: OMIM:612008
database_cross_reference: OMIM:612009
database_cross_reference: OMIM:612011
database_cross_reference: OMIM:612110
database_cross_reference: ORDO:555
database_cross_reference: SNOMEDCT_US_2016_03_01:155842007
database_cross_reference: SNOMEDCT_US_2016_03_01:197477005
database_cross_reference: SNOMEDCT_US_2016_03_01:197481005
database_cross_reference: SNOMEDCT_US_2016_03_01:23829007
database_cross_reference: SNOMEDCT_US_2016_03_01:266478000
database_cross_reference: SNOMEDCT_US_2016_03_01:396331005
database_cross_reference: UMLS_CUI:C0007570
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].
has_exact_synonym: celiac sprue
has_exact_synonym: coeliac disease
has_obo_namespace: disease_ontology
has_exact_synonym: idiopathic steatorrhea
definition: An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.
in_subset: DO MGI slim

renal hypertension
type: Class
subclass of: secondary hypertension
id: DOID:1073
database_cross_reference: MSH:D006977
database_cross_reference: NCI:C3121
database_cross_reference: SNOMEDCT_US_2015_03_01:194775007
database_cross_reference: SNOMEDCT_US_2015_03_01:28119000
database_cross_reference: UMLS_CUI:C0020544
has_obo_namespace: disease_ontology
imported from: doid.owl

hypertension
type: Class
subclass of: artery disease
id: DOID:10763
database_cross_reference: EFO:0000537
has_exact_synonym: HTN
has_exact_synonym: High blood pressure (& [essential hypertension])
database_cross_reference: ICD10CM:I10
database_cross_reference: ICD10CM:I10-I15
database_cross_reference: ICD9CM:401-405.99
database_cross_reference: ICD9CM:997.91
database_cross_reference: MSH:D006973
database_cross_reference: NCI:C3117
database_cross_reference: SNOMEDCT_US_2016_03_01:155295004
database_cross_reference: SNOMEDCT_US_2016_03_01:155302005
database_cross_reference: SNOMEDCT_US_2016_03_01:194756002
database_cross_reference: SNOMEDCT_US_2016_03_01:194757006
database_cross_reference: SNOMEDCT_US_2016_03_01:194760004
database_cross_reference: SNOMEDCT_US_2016_03_01:194794002
database_cross_reference: SNOMEDCT_US_2016_03_01:195537001
database_cross_reference: SNOMEDCT_US_2016_03_01:266287006
database_cross_reference: SNOMEDCT_US_2016_03_01:38341003
database_cross_reference: UMLS_CUI:C0020538
has_obo_namespace: disease_ontology
has_exact_synonym: hyperpiesia
has_related_synonym: hypertensive disease
has_exact_synonym: vascular hypertensive disorder
definition: An artery disease characterized by chronic elevated blood pressure in the arteries.

chronic frontal sinusitis
type: Class
subclass of: frontal sinusitis
id: DOID:10790
database_cross_reference: ICD10CM:J32.1
database_cross_reference: ICD9CM:473.1
database_cross_reference: NCI:C34473
database_cross_reference: SNOMEDCT_US_2015_03_01:155527004
database_cross_reference: SNOMEDCT_US_2015_03_01:195786002
database_cross_reference: SNOMEDCT_US_2015_03_01:60130002
database_cross_reference: UMLS_CUI:C0008683
has_obo_namespace: disease_ontology
definition: A frontal sinusitis which lasts for 12 weeks or more. This causes steady headache, localized tenderness and intermittent, purulent nasal and postnasal drainage.
imported from: doid.owl

frontal sinusitis
type: Class
subclass of: sinusitis
id: DOID:10791
database_cross_reference: ICD10CM:J32.1
database_cross_reference: MSH:D015522
database_cross_reference: NCI:C34626
database_cross_reference: SNOMEDCT_US_2015_03_01:195786002
database_cross_reference: SNOMEDCT_US_2015_03_01:275485006
database_cross_reference: SNOMEDCT_US_2015_03_01:78737005
database_cross_reference: UMLS_CUI:C0016735
has_obo_namespace: disease_ontology
definition: A sinusitis which involves infection of the frontal sinuses over the eyes in the brow area. This causes pain or pressure in the frontal sinus cavity and headache over the forehead.
imported from: doid.owl

chronic maxillary sinusitis
type: Class
subclass of: maxillary sinusitis
id: DOID:10792
database_cross_reference: ICD10CM:J32.0
database_cross_reference: ICD9CM:473.0
database_cross_reference: NCI:C34477
database_cross_reference: SNOMEDCT_US_2015_03_01:155526008
database_cross_reference: SNOMEDCT_US_2015_03_01:195785003
database_cross_reference: SNOMEDCT_US_2015_03_01:35923002
database_cross_reference: SNOMEDCT_US_2015_03_01:8299006
database_cross_reference: UMLS_CUI:C0008698
has_exact_synonym: chronic antritis
has_obo_namespace: disease_ontology
definition: A maxillary sinusitis which lasts for 12 weeks or more.
imported from: doid.owl

chronic sphenoidal sinusitis
type: Class
subclass of: sphenoid sinusitis
id: DOID:10793
database_cross_reference: ICD10CM:J32.3
database_cross_reference: ICD9CM:473.3
database_cross_reference: NCI:C34480
database_cross_reference: SNOMEDCT_US_2015_03_01:155528009
database_cross_reference: SNOMEDCT_US_2015_03_01:266384001
database_cross_reference: SNOMEDCT_US_2015_03_01:38961000
has_exact_synonym: Sphenoidal sinus-chr.
database_cross_reference: UMLS_CUI:C0008712
has_obo_namespace: disease_ontology
definition: A sphenoid sinusitis which lasts for 12 weeks or more.
imported from: doid.owl

sphenoid sinusitis
type: Class
subclass of: sinusitis
id: DOID:10794
database_cross_reference: ICD10CM:J32.3
database_cross_reference: MSH:D015524
database_cross_reference: NCI:C35031
database_cross_reference: SNOMEDCT_US_2015_03_01:13266007
has_exact_synonym: Sphenoidal sinusitis
database_cross_reference: UMLS_CUI:C0037886
has_obo_namespace: disease_ontology
definition: A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head.
imported from: doid.owl

malignant essential hypertension
type: Class
subclass of: malignant hypertension
subclass of: essential hypertension
has_exact_synonym: Accelerated essential hypertension
id: DOID:10823
database_cross_reference: ICD9CM:401.0
database_cross_reference: NCI:C34802
database_cross_reference: SNOMEDCT_US_2015_03_01:1218009
database_cross_reference: SNOMEDCT_US_2015_03_01:78975002
database_cross_reference: UMLS_CUI:C0024588
has_obo_namespace: disease_ontology
has_exact_synonym: malignant Essential hypertension
has_exact_synonym: malignant essential hypertension (disorder)
imported from: doid.owl

malignant hypertension
type: Class
subclass of: hypertension
id: DOID:10824
database_cross_reference: MSH:D006974
database_cross_reference: NCI:C3118
database_cross_reference: SNOMEDCT_US_2015_03_01:155301003
database_cross_reference: SNOMEDCT_US_2015_03_01:286951002
database_cross_reference: SNOMEDCT_US_2015_03_01:70272006
database_cross_reference: UMLS_CUI:C0020540
has_obo_namespace: disease_ontology
imported from: doid.owl

essential hypertension
type: Class
subclass of: hypertension
id: DOID:10825
database_cross_reference: ICD10CM:I10
database_cross_reference: ICD9CM:401
database_cross_reference: MSH:C562386
database_cross_reference: NCI:C3478
database_cross_reference: OMIM:145500
database_cross_reference: OMIM:603918
database_cross_reference: OMIM:604329
database_cross_reference: OMIM:607329
database_cross_reference: OMIM:608742
database_cross_reference: OMIM:610261
database_cross_reference: OMIM:610262
database_cross_reference: OMIM:610948
database_cross_reference: OMIM:611014
database_cross_reference: ORDO:243761
database_cross_reference: SNOMEDCT_US_2015_03_01:155296003
database_cross_reference: SNOMEDCT_US_2015_03_01:194757006
database_cross_reference: SNOMEDCT_US_2015_03_01:194760004
database_cross_reference: SNOMEDCT_US_2015_03_01:266228004
database_cross_reference: SNOMEDCT_US_2015_03_01:59621000
database_cross_reference: UMLS_CUI:C0085580
has_obo_namespace: disease_ontology
has_exact_synonym: idiopathic hypertension
has_exact_synonym: primary hypertension
definition: A hypertension with no known cause. It is the most common type of hypertension.
imported from: doid.owl
in_subset: DO MGI slim
in_subset: DO rare slim

microcephaly
type: Class
subclass of: congenital nervous system abnormality
id: DOID:10907
database_cross_reference: ICD10CM:Q02
database_cross_reference: ICD9CM:742.1
database_cross_reference: MSH:D008831
has_exact_synonym: Microcephalus
database_cross_reference: NCI:C85874
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:251200
database_cross_reference: OMIM:604321
database_cross_reference: OMIM:604804
database_cross_reference: OMIM:608393
database_cross_reference: OMIM:608716
database_cross_reference: OMIM:612703
database_cross_reference: SNOMEDCT_US_2016_03_01:156893009
database_cross_reference: SNOMEDCT_US_2016_03_01:1829003
database_cross_reference: SNOMEDCT_US_2016_03_01:204030002
database_cross_reference: SNOMEDCT_US_2016_03_01:204031003
database_cross_reference: UMLS_CUI:C0025958
has_obo_namespace: disease_ontology
has_exact_synonym: microencephaly
in_subset: DO FlyBase slim

benign essential hypertension
type: Class
subclass of: essential hypertension
id: DOID:10913
database_cross_reference: ICD9CM:401.1
database_cross_reference: NCI:C3656
database_cross_reference: SNOMEDCT_US_2015_03_01:1201005
database_cross_reference: SNOMEDCT_US_2015_03_01:194758001
database_cross_reference: UMLS_CUI:C0155583
has_exact_synonym: benign Essential hypertension
has_exact_synonym: benign essential hypertension (disorder)
has_obo_namespace: disease_ontology
imported from: doid.owl

fetal erythroblastosis
type: Class
subclass of: anemia
has_exact_synonym: (Haemolytic disease due to rhesus isoimmunisation) or (erythroblastosis fetalis) or (rhesus isoimmunisation of the newborn)
id: DOID:1098
has_exact_synonym: EF - Erythroblastosis foetalis
database_cross_reference: ICD10CM:P55
database_cross_reference: ICD10CM:P55.9
database_cross_reference: ICD9CM:773
database_cross_reference: ICD9CM:773.2
database_cross_reference: MSH:D004899
database_cross_reference: NCI:C101304
database_cross_reference: SNOMEDCT_US_2016_03_01:111468003
database_cross_reference: SNOMEDCT_US_2016_03_01:123307003
database_cross_reference: SNOMEDCT_US_2016_03_01:157130001
database_cross_reference: SNOMEDCT_US_2016_03_01:206429000
database_cross_reference: SNOMEDCT_US_2016_03_01:206430005
database_cross_reference: SNOMEDCT_US_2016_03_01:206431009
database_cross_reference: SNOMEDCT_US_2016_03_01:206436004
database_cross_reference: SNOMEDCT_US_2016_03_01:25121006
database_cross_reference: SNOMEDCT_US_2016_03_01:268878003
database_cross_reference: SNOMEDCT_US_2016_03_01:276577009
database_cross_reference: SNOMEDCT_US_2016_03_01:33130007
database_cross_reference: SNOMEDCT_US_2016_03_01:387705004
database_cross_reference: UMLS_CUI:C0014761
has_obo_namespace: disease_ontology
has_exact_synonym: erythroblastosis fetalis

placenta praevia
type: Class
subclass of: placenta disease
definition: A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.
id: DOID:11060
database_cross_reference: ICD10CM:O44
database_cross_reference: MSH:D010923
database_cross_reference: NCI:C26858
database_cross_reference: SNOMEDCT_US_2016_03_01:157059004
database_cross_reference: SNOMEDCT_US_2016_03_01:198930005
database_cross_reference: SNOMEDCT_US_2016_03_01:36813001
database_cross_reference: UMLS_CUI:C0032046
has_obo_namespace: disease_ontology

secondary hypertension
type: Class
subclass of: hypertension
id: DOID:11130
database_cross_reference: ICD10CM:I15
database_cross_reference: ICD10CM:I15.9
database_cross_reference: ICD9CM:405
database_cross_reference: ICD9CM:405.9
database_cross_reference: NCI:C3657
database_cross_reference: SNOMEDCT_US_2015_03_01:155300002
database_cross_reference: SNOMEDCT_US_2015_03_01:194789002
database_cross_reference: SNOMEDCT_US_2015_03_01:194792003
database_cross_reference: SNOMEDCT_US_2015_03_01:31992008
database_cross_reference: UMLS_CUI:C0155616
has_obo_namespace: disease_ontology
imported from: doid.owl

anemia of prematurity
type: Class
subclass of: neonatal anemia
has_exact_synonym: Anemia of prematurity (disorder)
id: DOID:11243
database_cross_reference: ICD10CM:P61.2
database_cross_reference: ICD9CM:776.6
database_cross_reference: NCI:C97167
database_cross_reference: SNOMEDCT_US_2016_03_01:47100003
database_cross_reference: UMLS_CUI:C0158996
has_obo_namespace: disease_ontology

neonatal anemia
type: Class
subclass of: anemia
has_exact_synonym: ANEMIA NEONATAL
id: DOID:11244
database_cross_reference: MSH:D000751
has_exact_synonym: Neonatal anemia (disorder)
has_exact_synonym: Neonatal anemia, NOS
database_cross_reference: SNOMEDCT_US_2016_03_01:111468003
database_cross_reference: SNOMEDCT_US_2016_03_01:234350007
database_cross_reference: SNOMEDCT_US_2016_03_01:276577009
database_cross_reference: SNOMEDCT_US_2016_03_01:33130007
database_cross_reference: UMLS_CUI:C0002891
has_obo_namespace: disease_ontology

heart disease
type: Class
subclass of: cardiovascular system disease
id: DOID:114
database_cross_reference: ICD10CM:I51.9
database_cross_reference: ICD9CM:429.9
database_cross_reference: MSH:D006331
database_cross_reference: NCI:C3079
database_cross_reference: SNOMEDCT_US_2016_03_01:155263000
database_cross_reference: SNOMEDCT_US_2016_03_01:194707003
database_cross_reference: SNOMEDCT_US_2016_03_01:195152001
database_cross_reference: SNOMEDCT_US_2016_03_01:266275004
database_cross_reference: SNOMEDCT_US_2016_03_01:266311004
database_cross_reference: SNOMEDCT_US_2016_03_01:56265001
database_cross_reference: UMLS_CUI:C0018799
has_obo_namespace: disease_ontology
definition: A cardiovascular system disease that involves the heart.
in_subset: DO FlyBase slim

mitral valve insufficiency
type: Class
subclass of: mitral valve disease
has_exact_synonym: Congenital insufficiency of mitral valve (disorder)
id: DOID:11502
has_alternative_id: DOID:11737
has_alternative_id: DOID:13947
database_cross_reference: ICD10CM:Q23.3
database_cross_reference: ICD9CM:396.3
database_cross_reference: ICD9CM:746.6
database_cross_reference: MSH:D008944
has_exact_synonym: Mitral valve incompetence
database_cross_reference: NCI:C50852
database_cross_reference: NCI:C50888
database_cross_reference: SNOMEDCT_US_2016_03_01:194736003
database_cross_reference: SNOMEDCT_US_2016_03_01:194977007
database_cross_reference: SNOMEDCT_US_2016_03_01:233857005
database_cross_reference: SNOMEDCT_US_2016_03_01:29928006
database_cross_reference: SNOMEDCT_US_2016_03_01:48724000
database_cross_reference: UMLS_CUI:C0026266
database_cross_reference: UMLS_CUI:C0158619
database_cross_reference: UMLS_CUI:C0264774
has_exact_synonym: congenital mitral insufficiency
has_exact_synonym: congenital mitral regurgitation
has_obo_namespace: disease_ontology
has_exact_synonym: mitral regurgitation

hypertensive heart disease
type: Class
subclass of: heart disease
id: DOID:11516
database_cross_reference: ICD10CM:I11
database_cross_reference: ICD10CM:I11.9
database_cross_reference: ICD9CM:402
database_cross_reference: ICD9CM:402.9
database_cross_reference: SNOMEDCT_US_2016_03_01:155297007
database_cross_reference: SNOMEDCT_US_2016_03_01:194769003
database_cross_reference: SNOMEDCT_US_2016_03_01:194772005
database_cross_reference: SNOMEDCT_US_2016_03_01:64715009
database_cross_reference: UMLS_CUI:C0152105
has_obo_namespace: disease_ontology
definition: A heart disease that is caused by high blood pressure.

benign hypertensive renal disease
type: Class
subclass of: renal hypertension
id: DOID:11520
database_cross_reference: ICD9CM:403.1
database_cross_reference: ICD9CM:403.10
database_cross_reference: SNOMEDCT_US_2015_03_01:193003
database_cross_reference: UMLS_CUI:C0155596
has_exact_synonym: benign hypertensive renal disease (disorder)
has_obo_namespace: disease_ontology
has_exact_synonym: hypertensive renal disease, benign
has_exact_synonym: hypertensive renal disease, benign, without mention of renal failure
imported from: doid.owl

nephrosclerosis
type: Class
subclass of: renal hypertension
id: DOID:11664
database_cross_reference: ICD10CM:I12
database_cross_reference: ICD10CM:N26.9
database_cross_reference: ICD9CM:587
database_cross_reference: MSH:D009400
database_cross_reference: SNOMEDCT_US_2015_03_01:194773000
database_cross_reference: SNOMEDCT_US_2015_03_01:197658002
database_cross_reference: SNOMEDCT_US_2015_03_01:197662008
database_cross_reference: SNOMEDCT_US_2015_03_01:32916005
database_cross_reference: UMLS_CUI:C0027719
has_obo_namespace: disease_ontology
has_exact_synonym: renal sclerosis
imported from: doid.owl

lipoatrophic diabetes
type: Class
subclass of: type 2 diabetes mellitus
id: DOID:11712
database_cross_reference: MSH:D003923
database_cross_reference: NCI:C34537
database_cross_reference: SNOMEDCT_US_2015_03_01:127012008
database_cross_reference: SNOMEDCT_US_2015_03_01:408543001
database_cross_reference: SNOMEDCT_US_2015_03_01:71325002
database_cross_reference: UMLS_CUI:C0011859
has_obo_namespace: disease_ontology
definition: A type 2 diabetes that involves severe lipodystrophy in addition to the traditional signs of diabetes.
imported from: doid.owl

gestational diabetes
type: Class
subclass of: diabetes mellitus
id: DOID:11714
database_cross_reference: EFO:0004593
has_exact_synonym: GDM
has_exact_synonym: Gestational diabetes mellitus
database_cross_reference: ICD10CM:O24.4
database_cross_reference: MSH:D016640
has_exact_synonym: Maternal gestational diabetes mellitus
database_cross_reference: NCI:C34942
database_cross_reference: SNOMEDCT_US_2015_03_01:11687002
database_cross_reference: SNOMEDCT_US_2015_03_01:199232003
database_cross_reference: SNOMEDCT_US_2015_03_01:237629002
database_cross_reference: SNOMEDCT_US_2015_03_01:359964007
database_cross_reference: SNOMEDCT_US_2015_03_01:393568003
database_cross_reference: UMLS_CUI:C0085207
has_obo_namespace: disease_ontology
imported from: doid.owl

prediabetes syndrome
type: Class
subclass of: diabetes mellitus
id: DOID:11716
database_cross_reference: ICD10CM:R73.09
database_cross_reference: MSH:D011236
has_exact_synonym: Prediabetes
database_cross_reference: SNOMEDCT_US_2015_03_01:15777000
database_cross_reference: SNOMEDCT_US_2015_03_01:9414007
database_cross_reference: UMLS_CUI:C0362046
has_obo_namespace: disease_ontology
has_exact_synonym: prediabetic state
imported from: doid.owl

neonatal diabetes mellitus
type: Class
subclass of: diabetes mellitus
id: DOID:11717
database_cross_reference: ICD10CM:P70.2
database_cross_reference: ICD9CM:775.1
database_cross_reference: NCI:C99248
database_cross_reference: SNOMEDCT_US_2015_03_01:49817004
database_cross_reference: UMLS_CUI:C0158981
has_exact_synonym: diabetes mellitus syndrome in newborn infant
has_obo_namespace: disease_ontology
imported from: doid.owl

clubfoot
type: Class
subclass of: bone development disease
has_exact_synonym: Congenital equinovarus
has_alternative_id: DOID:0001874
id: DOID:11836
has_exact_synonym: Equinovarus deformity of foot (finding)
database_cross_reference: ICD10CM:Q66.0
database_cross_reference: ICD10CM:Q66.89
database_cross_reference: ICD9CM:754.51
database_cross_reference: MSH:D003025
database_cross_reference: NCI:C84641
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:119800
database_cross_reference: SNOMEDCT_US_2016_03_01:15169008
database_cross_reference: SNOMEDCT_US_2016_03_01:156985005
database_cross_reference: SNOMEDCT_US_2016_03_01:156987002
database_cross_reference: SNOMEDCT_US_2016_03_01:205089003
database_cross_reference: SNOMEDCT_US_2016_03_01:249808002
database_cross_reference: SNOMEDCT_US_2016_03_01:253957000
database_cross_reference: SNOMEDCT_US_2016_03_01:268340009
database_cross_reference: SNOMEDCT_US_2016_03_01:268341008
database_cross_reference: SNOMEDCT_US_2016_03_01:33163000
database_cross_reference: SNOMEDCT_US_2016_03_01:397932003
database_cross_reference: UMLS_CUI:C0009081
has_exact_synonym: congenital clubfoot
has_exact_synonym: congenital talipes equinovarus
has_obo_namespace: disease_ontology
definition: A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

nephrotic syndrome
type: Class
subclass of: nephrosis
id: DOID:1184
database_cross_reference: ICD10CM:N04
database_cross_reference: ICD9CM:581
database_cross_reference: MSH:D009404
database_cross_reference: NCI:C34845
database_cross_reference: OMIM:256300
database_cross_reference: OMIM:256370
database_cross_reference: OMIM:600995
database_cross_reference: OMIM:610725
database_cross_reference: OMIM:614196
database_cross_reference: OMIM:614199
database_cross_reference: OMIM:615008
database_cross_reference: OMIM:615244
database_cross_reference: OMIM:615573
database_cross_reference: OMIM:615861
database_cross_reference: SNOMEDCT_US_2016_03_01:155851004
database_cross_reference: SNOMEDCT_US_2016_03_01:197611005
database_cross_reference: SNOMEDCT_US_2016_03_01:52254009
database_cross_reference: UMLS_CUI:C0027726
comment: Xref MGI.
has_obo_namespace: disease_ontology
has_exact_synonym: finnish congenital nephrosis
in_subset: DO MGI slim

kernicterus due to isoimmunization
type: Class
subclass of: neonatal anemia
id: DOID:12043
database_cross_reference: ICD10CM:P57.0
database_cross_reference: ICD9CM:773.4
has_exact_synonym: Kernicterus - due to isoimm.
has_exact_synonym: Kernicterus due to isoimmunization (disorder)
has_exact_synonym: Kernicterus due to isoimmunization [dup] (disorder)
has_exact_synonym: Kernicterus due to isoimmunization of fetus or newborn
database_cross_reference: NCI:C101270
database_cross_reference: SNOMEDCT_US_2016_03_01:157135006
database_cross_reference: SNOMEDCT_US_2016_03_01:206433007
database_cross_reference: SNOMEDCT_US_2016_03_01:268880009
database_cross_reference: SNOMEDCT_US_2016_03_01:359007
database_cross_reference: UMLS_CUI:C0270204
has_obo_namespace: disease_ontology

allergic hypersensitivity disease
type: Class
subclass of: hypersensitivity reaction disease
id: DOID:1205
database_cross_reference: ICD10CM:T78.40
database_cross_reference: MSH:D006967
database_cross_reference: NCI:C3114
database_cross_reference: SNOMEDCT_US_2016_03_01:106190000
database_cross_reference: SNOMEDCT_US_2016_03_01:127072000
database_cross_reference: SNOMEDCT_US_2016_03_01:157754004
database_cross_reference: SNOMEDCT_US_2016_03_01:157758001
database_cross_reference: SNOMEDCT_US_2016_03_01:212998004
database_cross_reference: SNOMEDCT_US_2016_03_01:212999007
database_cross_reference: SNOMEDCT_US_2016_03_01:21957007
database_cross_reference: SNOMEDCT_US_2016_03_01:257550005
database_cross_reference: SNOMEDCT_US_2016_03_01:269284003
database_cross_reference: SNOMEDCT_US_2016_03_01:269432007
database_cross_reference: SNOMEDCT_US_2016_03_01:274211000
database_cross_reference: SNOMEDCT_US_2016_03_01:282092005
database_cross_reference: SNOMEDCT_US_2016_03_01:418168000
database_cross_reference: SNOMEDCT_US_2016_03_01:418634005
database_cross_reference: SNOMEDCT_US_2016_03_01:418925002
database_cross_reference: SNOMEDCT_US_2016_03_01:421668005
database_cross_reference: SNOMEDCT_US_2016_03_01:421961002
database_cross_reference: SNOMEDCT_US_2016_03_01:91232002
database_cross_reference: UMLS_CUI:C0020517
has_exact_synonym: allergic disease
has_exact_synonym: allergy
has_obo_namespace: disease_ontology
has_exact_synonym: hypersensitivity
has_exact_synonym: hypersensitivity reaction type I disease
definition: An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.

oligohydramnios
type: Class
subclass of: placenta disease
definition: A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.
id: DOID:12215
has_alternative_id: DOID:12595
has_alternative_id: DOID:12596
database_cross_reference: ICD10CM:O41.0
database_cross_reference: ICD10CM:O41.00
database_cross_reference: ICD9CM:658.0
database_cross_reference: MSH:D016104
database_cross_reference: NCI:C92839
has_exact_synonym: Oligohydramnios - delivered
database_cross_reference: SNOMEDCT_US_2016_03_01:156190009
database_cross_reference: SNOMEDCT_US_2016_03_01:157051001
database_cross_reference: SNOMEDCT_US_2016_03_01:199652007
database_cross_reference: SNOMEDCT_US_2016_03_01:199656005
database_cross_reference: SNOMEDCT_US_2016_03_01:59566000
database_cross_reference: UMLS_CUI:C0079924
has_exact_synonym: antepartum oligohydramnios
has_exact_synonym: delivered oligohydramnios
has_obo_namespace: disease_ontology

hepatitis A
type: Class
subclass of: viral infectious disease
has_alternative_id: DOID:12547
id: DOID:12549
database_cross_reference: MSH:D006506
database_cross_reference: NCI:C3096
database_cross_reference: SNOMEDCT_US_2016_03_01:154347003
database_cross_reference: SNOMEDCT_US_2016_03_01:40468003
database_cross_reference: UMLS_CUI:C0019159
has_related_synonym: Viral hepatitis A
has_exact_synonym: Viral hepatitis, type A (disorder)
has_obo_namespace: disease_ontology
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

hiatus hernia
type: Class
subclass of: gastrointestinal system disease
id: DOID:12642
has_exact_synonym: Diaphragmatic - hiatus -hernia
has_exact_synonym: Hiatal hernia (disorder)
has_exact_synonym: Hiatus hernia
database_cross_reference: ICD10CM:K44
database_cross_reference: MSH:D006551
database_cross_reference: NCI:C98945
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:142400
database_cross_reference: SNOMEDCT_US_2016_03_01:155748004
database_cross_reference: SNOMEDCT_US_2016_03_01:196901006
database_cross_reference: SNOMEDCT_US_2016_03_01:196910003
database_cross_reference: SNOMEDCT_US_2016_03_01:196914007
database_cross_reference: SNOMEDCT_US_2016_03_01:236053002
database_cross_reference: SNOMEDCT_US_2016_03_01:266511003
database_cross_reference: SNOMEDCT_US_2016_03_01:309811003
database_cross_reference: SNOMEDCT_US_2016_03_01:3662000
database_cross_reference: SNOMEDCT_US_2016_03_01:84089009
database_cross_reference: UMLS_CUI:C0267725
database_cross_reference: UMLS_CUI:C0376710
database_cross_reference: UMLS_CUI:C3489393
has_obo_namespace: disease_ontology
has_exact_synonym: hiatal hernia

cardiovascular system disease
type: Class
subclass of: disease
id: DOID:1287
has_alternative_id: DOID:73
database_cross_reference: ICD9CM:429.2
database_cross_reference: MSH:D002318
database_cross_reference: NCI:C2931
database_cross_reference: SNOMEDCT_US_2016_03_01:155263000
database_cross_reference: SNOMEDCT_US_2016_03_01:194707003
database_cross_reference: SNOMEDCT_US_2016_03_01:195139006
database_cross_reference: SNOMEDCT_US_2016_03_01:195594006
database_cross_reference: SNOMEDCT_US_2016_03_01:266275004
database_cross_reference: SNOMEDCT_US_2016_03_01:266336005
database_cross_reference: SNOMEDCT_US_2016_03_01:49601007
database_cross_reference: UMLS_CUI:C0007222
has_exact_synonym: disease of subdivision of hemolymphoid system
has_obo_namespace: disease_ontology
definition: A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.

persistent fetal circulation syndrome
type: Class
subclass of: pulmonary hypertension
id: DOID:13042
has_exact_synonym: Fetal circulation
database_cross_reference: ICD10CM:P29.3
database_cross_reference: ICD9CM:747.83
database_cross_reference: MSH:D010547
database_cross_reference: NCI:C85006
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:265380
has_exact_synonym: Persistent fetal circulation
has_exact_synonym: Persistent fetal circulation (disorder)
has_exact_synonym: Persistent fetal circulation syndrome (disorder)
has_exact_synonym: Persistent pulmonary hypertension of the newborn (disorder)
database_cross_reference: SNOMEDCT_US_2015_03_01:204507004
database_cross_reference: SNOMEDCT_US_2015_03_01:206597007
database_cross_reference: SNOMEDCT_US_2015_03_01:233815004
database_cross_reference: SNOMEDCT_US_2015_03_01:35604006
database_cross_reference: UMLS_CUI:C0031190
has_exact_synonym: congenital alveolar capillary dysplasia with misalignment of pulmonary veins
has_obo_namespace: disease_ontology
has_exact_synonym: persistent pulmonary hypertension of the newborn
imported from: doid.owl

acute sphenoidal sinusitis
type: Class
subclass of: sphenoid sinusitis
id: DOID:13046
database_cross_reference: ICD10CM:J01.3
database_cross_reference: ICD10CM:J01.30
database_cross_reference: ICD9CM:461.3
database_cross_reference: SNOMEDCT_US_2015_03_01:155501004
database_cross_reference: SNOMEDCT_US_2015_03_01:266378004
database_cross_reference: SNOMEDCT_US_2015_03_01:77919000
has_exact_synonym: Sphenoidal sinus -acute
database_cross_reference: UMLS_CUI:C0155807
has_obo_namespace: disease_ontology
definition: A sphenoid sinusitis which lasts for less than 4 weeks.
imported from: doid.owl

severe pre-eclampsia
type: Class
subclass of: pre-eclampsia
id: DOID:13129
has_alternative_id: DOID:13130
has_alternative_id: DOID:13131
has_alternative_id: DOID:13132
database_cross_reference: ICD9CM:642.50
has_exact_synonym: Severe pre-eclampsia, with delivery
database_cross_reference: UMLS_CUI:C0156669
has_exact_synonym: antepartum severe pre-eclampsia
has_obo_namespace: disease_ontology
has_exact_synonym: postpartum severe pre-eclampsia
has_exact_synonym: severe preeclampsia
definition: A pre-eclampsia that has_symptom at least one of the following: SBP of 160mm HG or higher or DPB of 110mm HG or higher on 2 occasions at least 6 hours apart, proteinuria more than 5g in a 24-hour collection, pulmonary edema or cyanosis, oliguria, persistent headaches, epigastric pain and/or impaired liver function, thrombocytopenia, oligohydramnios, decreased fetal growth or placental abruption.
imported from: doid.owl

HELLP syndrome
type: Class
subclass of: severe pre-eclampsia
id: DOID:13133
has_exact_synonym: HELLP syndrome (disorder)
database_cross_reference: ICD10CM:O14.2
database_cross_reference: MSH:D017359
database_cross_reference: NCI:C84750
database_cross_reference: SNOMEDCT_US_2015_03_01:199010001
database_cross_reference: SNOMEDCT_US_2015_03_01:95605009
database_cross_reference: UMLS_CUI:C0162739
has_obo_namespace: disease_ontology
has_exact_synonym: syndrome of haemolysis, elevated liver enzymes and low platelet
definition: A severe pre-eclampsia characterized by hemolysis, elevated liver enzyme and low platelet count.
imported from: doid.owl

benign secondary hypertension
type: Class
subclass of: secondary hypertension
id: DOID:13143
database_cross_reference: ICD9CM:405.1
database_cross_reference: NCI:C3658
database_cross_reference: SNOMEDCT_US_2015_03_01:194785008
database_cross_reference: SNOMEDCT_US_2015_03_01:194787000
database_cross_reference: SNOMEDCT_US_2015_03_01:44111003
database_cross_reference: UMLS_CUI:C0155620
has_obo_namespace: disease_ontology
imported from: doid.owl

benign renovascular hypertension
type: Class
subclass of: benign secondary hypertension
id: DOID:13145
database_cross_reference: ICD9CM:405.11
database_cross_reference: UMLS_CUI:C0155621
has_obo_namespace: disease_ontology
imported from: doid.owl

congenital toxoplasmosis
type: Class
subclass of: toxoplasmosis
has_exact_synonym: Congenital toxoplasmosis
has_exact_synonym: Congenital toxoplasmosis (disorder)
id: DOID:13336
database_cross_reference: ICD10CM:P37.1
database_cross_reference: MSH:D014125
database_cross_reference: NCI:C50503
database_cross_reference: SNOMEDCT_US_2016_03_01:157118007
database_cross_reference: SNOMEDCT_US_2016_03_01:206335001
database_cross_reference: SNOMEDCT_US_2016_03_01:268875000
database_cross_reference: SNOMEDCT_US_2016_03_01:73893000
has_exact_synonym: Toxoplasmosis - congen.
database_cross_reference: UMLS_CUI:C0040560
has_obo_namespace: disease_ontology
definition: A toxoplasmosis that involves a reactivated infection of the mother transmitted to the fetus during pregnancy. Spontaneous abortion and stillbirth may occur.

twin-to-twin transfusion syndrome
type: Class
subclass of: neonatal anemia
id: DOID:13576
has_exact_synonym: Fetal blood loss from fetal hemorrhage into co-twin
has_exact_synonym: Fetal hemorrhage into co-twin (disorder)
database_cross_reference: ICD10CM:O43.02
database_cross_reference: ICD10CM:O43.029
database_cross_reference: MSH:D005330
database_cross_reference: NCI:C113824
database_cross_reference: SNOMEDCT_US_2016_03_01:13404009
database_cross_reference: SNOMEDCT_US_2016_03_01:237299001
has_exact_synonym: Twin to twin transfusion
has_exact_synonym: Twin-to-twin blood transfer (disorder)
database_cross_reference: UMLS_CUI:C2909036
has_obo_namespace: disease_ontology

eclampsia
type: Class
subclass of: pre-eclampsia
has_alternative_id: DOID:13592
id: DOID:13593
has_exact_synonym: Eclampsia in puerperium (disorder)
has_exact_synonym: Eclampsia, postpartum
database_cross_reference: ICD10CM:O15
database_cross_reference: ICD10CM:O15.9
database_cross_reference: MSH:D004461
database_cross_reference: NCI:C87167
has_exact_synonym: Postpartum eclampsia
database_cross_reference: SNOMEDCT_US_2015_03_01:156111007
database_cross_reference: SNOMEDCT_US_2015_03_01:15938005
database_cross_reference: SNOMEDCT_US_2015_03_01:198988006
database_cross_reference: SNOMEDCT_US_2015_03_01:198989003
database_cross_reference: SNOMEDCT_US_2015_03_01:198996001
database_cross_reference: UMLS_CUI:C0013537
has_obo_namespace: disease_ontology
definition: A pre-eclampsia characterized by the presence of seizures.
imported from: doid.owl

malignant renovascular hypertension
type: Class
subclass of: malignant secondary hypertension
id: DOID:13730
has_obo_namespace: disease_ontology
imported from: doid.owl

malignant secondary hypertension
type: Class
subclass of: malignant hypertension
subclass of: secondary hypertension
id: DOID:13731
database_cross_reference: ICD9CM:405.0
database_cross_reference: SNOMEDCT_US_2015_03_01:194784007
database_cross_reference: SNOMEDCT_US_2015_03_01:49863005
database_cross_reference: SNOMEDCT_US_2015_03_01:89242004
database_cross_reference: UMLS_CUI:C0155617
has_obo_namespace: disease_ontology
imported from: doid.owl

parasitic infectious disease
type: Class
subclass of: disease
has_alternative_id: DOID:11681
has_alternative_id: DOID:13509
has_alternative_id: DOID:1396
id: DOID:1398
has_alternative_id: DOID:1494
has_alternative_id: DOID:2114
has_alternative_id: DOID:2293
has_alternative_id: DOID:2922
has_alternative_id: DOID:3564
has_alternative_id: DOID:4191
has_alternative_id: DOID:886
has_alternative_id: DOID:948
has_alternative_id: DOID:9639
has_alternative_id: DOID:9644
has_exact_synonym: Ectoparasitic disease
database_cross_reference: ICD10CM:H44.12
database_cross_reference: ICD9CM:360.13
database_cross_reference: NCI:C34587
database_cross_reference: SNOMEDCT_US_2016_03_01:193273005
database_cross_reference: SNOMEDCT_US_2016_03_01:57100005
database_cross_reference: UMLS_CUI:C0014238
has_obo_namespace: disease_ontology
has_exact_synonym: parasitemia
definition: A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host.

acute frontal sinusitis
type: Class
subclass of: frontal sinusitis
id: DOID:14225
database_cross_reference: ICD10CM:J01.1
database_cross_reference: ICD10CM:J01.10
database_cross_reference: ICD9CM:461.1
database_cross_reference: SNOMEDCT_US_2015_03_01:155500003
database_cross_reference: SNOMEDCT_US_2015_03_01:91038008
database_cross_reference: UMLS_CUI:C0155805
has_obo_namespace: disease_ontology
definition: A frontal sinusitis which lasts for less than 4 weeks.
imported from: doid.owl

pulmonary valve insufficiency
type: Class
subclass of: pulmonary valve disease
definition: A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur.
has_alternative_id: DOID:11210
id: DOID:14265
database_cross_reference: MSH:D011665
database_cross_reference: NCI:C50848
database_cross_reference: NCI:C51447
database_cross_reference: NCI:C62436
has_exact_synonym: Pulmonic insufficiency NOS
has_exact_synonym: Pulmonic valve regurgitation (disorder)
comment: Replacing outdated UMLS CUI.
database_cross_reference: SNOMEDCT_US_2015_03_01:91434003
database_cross_reference: UMLS_CUI:C0034088
has_obo_namespace: disease_ontology
has_exact_synonym: pulmonary incompetence
has_exact_synonym: pulmonary incompetence, non-rheumatic (disorder)
has_exact_synonym: pulmonary insufficiency following trauma and surgery
has_exact_synonym: pulmonary regurg.
has_exact_synonym: pulmonary regurgitation
imported from: doid.owl

Ebstein anomaly
type: Class
subclass of: tricuspid valve disease
id: DOID:14289
has_exact_synonym: Ebstein's anomaly
has_exact_synonym: Ebstein's anomaly (disorder) [Ambiguous]
has_exact_synonym: Ebstein's anomaly of common atrioventricular valve (disorder)
has_exact_synonym: Ebstein's anomaly of right atrioventricular valve (disorder)
has_exact_synonym: Ebstein's anomaly of tricuspid valve (disorder)
database_cross_reference: ICD10CM:Q22.5
database_cross_reference: ICD9CM:746.2
database_cross_reference: MSH:D004437
database_cross_reference: NCI:C84681
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:224700
database_cross_reference: SNOMEDCT_US_2016_03_01:1796006
database_cross_reference: SNOMEDCT_US_2016_03_01:204357006
database_cross_reference: UMLS_CUI:C0013481
has_obo_namespace: disease_ontology
definition: A tricuspid valve disease that is a congenital heart defect in which the septal leaflet of the tricuspid valve is displaced towards the apex of the right ventricle of the heart.

hypothyroidism
type: Class
subclass of: endocrine system disease
has_alternative_id: DOID:11630
id: DOID:1459
database_cross_reference: EFO:0004705
database_cross_reference: ICD10CM:E03.9
database_cross_reference: ICD9CM:244.9
database_cross_reference: MSH:D007037
database_cross_reference: NCI:C26800
database_cross_reference: SNOMEDCT_US_2016_03_01:154660000
database_cross_reference: SNOMEDCT_US_2016_03_01:190274003
database_cross_reference: SNOMEDCT_US_2016_03_01:190290003
database_cross_reference: SNOMEDCT_US_2016_03_01:237572004
database_cross_reference: SNOMEDCT_US_2016_03_01:267377003
database_cross_reference: SNOMEDCT_US_2016_03_01:267465007
database_cross_reference: SNOMEDCT_US_2016_03_01:40930008
has_exact_synonym: Thyroid deficiency
has_exact_synonym: Thyroid insufficiency
database_cross_reference: UMLS_CUI:C0020676
has_obo_namespace: disease_ontology
definition: A thyroid gland disease which involves an underproduction of thyroid hormone.

disease of mental health
type: Class
subclass of: disease
definition: A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.
id: DOID:150
database_cross_reference: ICD10CM:F99
database_cross_reference: ICD10CM:F99-F99
database_cross_reference: MSH:D001523
database_cross_reference: NCI:C2893
database_cross_reference: SNOMEDCT_US_2016_03_01:154843007
database_cross_reference: SNOMEDCT_US_2016_03_01:154971002
database_cross_reference: SNOMEDCT_US_2016_03_01:154972009
database_cross_reference: SNOMEDCT_US_2016_03_01:154980002
database_cross_reference: SNOMEDCT_US_2016_03_01:192637001
database_cross_reference: SNOMEDCT_US_2016_03_01:192639003
database_cross_reference: SNOMEDCT_US_2016_03_01:74732009
database_cross_reference: UMLS_CUI:C0004936
has_obo_namespace: disease_ontology

Axiom
annotated target: A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.
database_cross_reference: url:http://en.wikipedia.org/wiki/Mental_disorder
annotated source: disease of mental health
annotated property: definition

respiratory system disease
type: Class
subclass of: disease
id: DOID:1579
has_alternative_id: DOID:3226
database_cross_reference: ICD10CM:J96-J99
database_cross_reference: ICD10CM:J98
database_cross_reference: ICD9CM:510-519.99
database_cross_reference: ICD9CM:519
database_cross_reference: SNOMEDCT_US_2016_03_01:155603009
database_cross_reference: SNOMEDCT_US_2016_03_01:196057004
database_cross_reference: SNOMEDCT_US_2016_03_01:196184000
database_cross_reference: SNOMEDCT_US_2016_03_01:196255004
database_cross_reference: SNOMEDCT_US_2016_03_01:266373008
database_cross_reference: UMLS_CUI:C0029582
has_obo_namespace: disease_ontology
definition: A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm.

renovascular hypertension
type: Class
subclass of: renal hypertension
id: DOID:1591
database_cross_reference: ICD10CM:I15.0
database_cross_reference: MSH:D006978
database_cross_reference: NCI:C85044
has_exact_synonym: Renovascular hypertension (disorder)
database_cross_reference: SNOMEDCT_US_2015_03_01:123799005
database_cross_reference: SNOMEDCT_US_2015_03_01:194790006
database_cross_reference: UMLS_CUI:C0020545
has_obo_namespace: disease_ontology
imported from: doid.owl

congenital heart disease
type: Class
subclass of: heart disease
has_exact_synonym: Congenital Heart Defects
has_exact_synonym: Congenital anomaly of heart
id: DOID:1682
has_exact_synonym: Heart Malformation
has_related_synonym: Heart-congenital defect
database_cross_reference: ICD10CM:Q24.9
database_cross_reference: ICD9CM:746.9
database_cross_reference: MSH:D006330
database_cross_reference: NCI:C34666
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: SNOMEDCT_US_2016_03_01:13213009
database_cross_reference: SNOMEDCT_US_2016_03_01:156911006
database_cross_reference: SNOMEDCT_US_2016_03_01:156926008
database_cross_reference: SNOMEDCT_US_2016_03_01:204405005
database_cross_reference: SNOMEDCT_US_2016_03_01:204413006
database_cross_reference: SNOMEDCT_US_2016_03_01:268315002
database_cross_reference: SNOMEDCT_US_2016_03_01:268318000
database_cross_reference: UMLS_CUI:C0018798
has_exact_synonym: congenital heart defect
has_obo_namespace: disease_ontology
has_exact_synonym: heart defect
in_subset: DO FlyBase slim

musculoskeletal system disease
type: Class
subclass of: disease
id: DOID:17
database_cross_reference: MSH:D009140
database_cross_reference: NCI:C107377
database_cross_reference: SNOMEDCT_US_2016_03_01:156881000
database_cross_reference: SNOMEDCT_US_2016_03_01:268047003
database_cross_reference: SNOMEDCT_US_2016_03_01:268142006
database_cross_reference: SNOMEDCT_US_2016_03_01:274149006
database_cross_reference: SNOMEDCT_US_2016_03_01:928000
database_cross_reference: UMLS_CUI:C0026857
has_obo_namespace: disease_ontology
definition: A disease of anatomical entity that occurs in the muscular and/or skeletal system.

aortic valve stenosis
type: Class
subclass of: aortic valve disease
has_exact_synonym: AS
definition: An aortic valve disease that has_physical_basis_in incomplete opening of the aortic valve.
has_exact_synonym: Aortic stenosis
has_exact_synonym: Congenital aortic valve stenosis
has_alternative_id: DOID:12034
has_alternative_id: DOID:1711
id: DOID:1712
database_cross_reference: ICD10CM:I06.0
database_cross_reference: ICD10CM:Q23.0
database_cross_reference: ICD9CM:395.0
database_cross_reference: ICD9CM:746.3
database_cross_reference: MSH:D001024
database_cross_reference: NCI:C50462
database_cross_reference: OMIM:109730
database_cross_reference: OMIM:614823
database_cross_reference: ORDO:402075
has_exact_synonym: Rheumatic aortic stenosis
database_cross_reference: SNOMEDCT_US_2015_03_01:155282009
database_cross_reference: SNOMEDCT_US_2015_03_01:156922005
database_cross_reference: SNOMEDCT_US_2015_03_01:18546004
database_cross_reference: SNOMEDCT_US_2015_03_01:390722003
database_cross_reference: SNOMEDCT_US_2015_03_01:60573004
database_cross_reference: SNOMEDCT_US_2015_03_01:72011007
database_cross_reference: UMLS_CUI:C0003507
database_cross_reference: UMLS_CUI:C0152417
database_cross_reference: UMLS_CUI:C0155567
has_obo_namespace: disease_ontology
has_exact_synonym: rheumatic aortic valve stenosis
imported from: doid.owl
in_subset: DO MGI slim
in_subset: DO rare slim

mitral valve stenosis
type: Class
subclass of: mitral valve disease
definition: A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart.
id: DOID:1754
database_cross_reference: MSH:D008946
has_exact_synonym: Mitral stenosis
database_cross_reference: NCI:C50654
database_cross_reference: SNOMEDCT_US_2016_03_01:155277002
database_cross_reference: SNOMEDCT_US_2016_03_01:194725005
database_cross_reference: SNOMEDCT_US_2016_03_01:79619009
database_cross_reference: UMLS_CUI:C0026269
has_obo_namespace: disease_ontology

vascular disease
type: Class
subclass of: cardiovascular system disease
has_alternative_id: DOID:0000405
id: DOID:178
has_alternative_id: DOID:2403
has_alternative_id: DOID:2869
has_alternative_id: DOID:324
has_alternative_id: DOID:325
has_alternative_id: DOID:45
database_cross_reference: ICD10CM:I72.9
database_cross_reference: ICD9CM:442.9
database_cross_reference: MSH:D000783
database_cross_reference: MSH:D014652
database_cross_reference: MSH:D020758
database_cross_reference: MSH:D020760
database_cross_reference: NCI:C26693
database_cross_reference: NCI:C35117
database_cross_reference: SNOMEDCT_US_2016_03_01:134342004
database_cross_reference: SNOMEDCT_US_2016_03_01:155425005
database_cross_reference: SNOMEDCT_US_2016_03_01:155428007
database_cross_reference: SNOMEDCT_US_2016_03_01:195292009
database_cross_reference: SNOMEDCT_US_2016_03_01:27550009
database_cross_reference: SNOMEDCT_US_2016_03_01:362727005
database_cross_reference: SNOMEDCT_US_2016_03_01:371029002
database_cross_reference: SNOMEDCT_US_2016_03_01:432119003
database_cross_reference: SNOMEDCT_US_2016_03_01:85659009
database_cross_reference: UMLS_CUI:C0002940
database_cross_reference: UMLS_CUI:C0042373
database_cross_reference: UMLS_CUI:C0752127
database_cross_reference: UMLS_CUI:C0752130
has_obo_namespace: disease_ontology
has_exact_synonym: vascular tissue disease
definition: A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.

urinary system disease
type: Class
subclass of: disease
id: DOID:18
has_alternative_id: DOID:579
database_cross_reference: NCI:C27599
has_exact_synonym: Non-neoplastic urinary tract disease
database_cross_reference: UMLS_CUI:C1335051
has_obo_namespace: disease_ontology
has_exact_synonym: urinary tract disease
definition: A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

diabetic ketoacidosis
type: Class
subclass of: type 2 diabetes mellitus
has_exact_synonym: DIABETES MELLITUS, KETOSIS-PRONE
id: DOID:1837
database_cross_reference: ICD9CM:250.1
database_cross_reference: MSH:D016883
database_cross_reference: NCI:C50530
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:612227
database_cross_reference: SNOMEDCT_US_2015_03_01:154671004
database_cross_reference: SNOMEDCT_US_2015_03_01:190328004
database_cross_reference: SNOMEDCT_US_2015_03_01:24927004
database_cross_reference: SNOMEDCT_US_2015_03_01:267467004
database_cross_reference: SNOMEDCT_US_2015_03_01:420422005
database_cross_reference: UMLS_CUI:C0011880
has_obo_namespace: disease_ontology
has_exact_synonym: ketosis-prone diabetes mellitus
imported from: doid.owl

cannabis dependence
type: Class
subclass of: hallucinogen dependence
definition: A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.
id: DOID:1849
database_cross_reference: ICD10CM:F12.2
database_cross_reference: ICD9CM:304.3
database_cross_reference: MSH:D002189
database_cross_reference: NCI:C34445
database_cross_reference: SNOMEDCT_US_2016_03_01:191835009
database_cross_reference: SNOMEDCT_US_2016_03_01:191836005
database_cross_reference: SNOMEDCT_US_2016_03_01:268766005
database_cross_reference: SNOMEDCT_US_2016_03_01:85005007
database_cross_reference: UMLS_CUI:C0006870
has_obo_namespace: disease_ontology

Axiom
annotated target: A drug dependence that involves the continued use of cannabis despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Cannabis_dependence
annotated source: cannabis dependence
annotated property: definition

hepatitis C
type: Class
subclass of: viral infectious disease
has_alternative_id: DOID:12430
has_alternative_id: DOID:12432
id: DOID:1883
has_alternative_id: DOID:2049
database_cross_reference: EFO:0003047
database_cross_reference: ICD10CM:B19.2
database_cross_reference: ICD10CM:B19.20
database_cross_reference: ICD9CM:070.7
database_cross_reference: MSH:D006526
has_exact_synonym: NANBH
database_cross_reference: NCI:C3098
database_cross_reference: SNOMEDCT_US_2016_03_01:123324009
database_cross_reference: SNOMEDCT_US_2016_03_01:154349000
database_cross_reference: SNOMEDCT_US_2016_03_01:186634008
database_cross_reference: SNOMEDCT_US_2016_03_01:186643004
database_cross_reference: SNOMEDCT_US_2016_03_01:50711007
database_cross_reference: UMLS_CUI:C0019196
has_exact_synonym: Viral hepatitis C
has_exact_synonym: chronic hepatitis C
has_obo_namespace: disease_ontology
has_exact_synonym: hepatitis C infection
has_exact_synonym: hepatitis nonA nonB
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

viral hepatitis
type: Class
subclass of: hepatitis
has_alternative_id: DOID:12548
has_alternative_id: DOID:1331
id: DOID:1884
has_alternative_id: DOID:1885
database_cross_reference: MSH:D006524
database_cross_reference: UMLS_CUI:C0019194
has_exact_synonym: Unspecified viral hepatitis with hepatic coma
has_exact_synonym: Viral hepatitis with hepatic coma (disorder)
has_exact_synonym: animal viral hepatitis
has_obo_namespace: disease_ontology
has_exact_synonym: human viral hepatitis
has_exact_synonym: viral hepatitis with hepatic coma
definition: A hepatitis that involves viral infection causing inflammation of the liver.

supravalvular aortic stenosis
type: Class
subclass of: aortic valve stenosis
id: DOID:1929
database_cross_reference: ICD10CM:Q25.3
database_cross_reference: MSH:D021921
database_cross_reference: NCI:C85176
database_cross_reference: OMIM:185500
database_cross_reference: OMIM:194050
database_cross_reference: SNOMEDCT_US_2015_03_01:204436002
database_cross_reference: SNOMEDCT_US_2015_03_01:268185002
has_exact_synonym: Supra-valvular aortic stenosis
has_exact_synonym: Supravalvar aortic stenosis (disorder)
database_cross_reference: UMLS_CUI:C0003499
has_obo_namespace: disease_ontology
imported from: doid.owl

hepatitis B
type: Class
subclass of: viral infectious disease
has_alternative_id: DOID:12591
has_alternative_id: DOID:12592
has_alternative_id: DOID:2042
id: DOID:2043
has_related_synonym: Serum hepatitis
has_exact_synonym: chronic hepatitis B
has_obo_namespace: disease_ontology
has_exact_synonym: hepatitis B infection
definition: A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.
in_subset: sexually transmitted infectious disease

autoimmune hepatitis
type: Class
subclass of: autoimmune disease of gastrointestinal tract
has_exact_synonym: Autoimmune Hepatitis
has_exact_synonym: Autoimmune chronic active hepatitis
has_exact_synonym: Autoimmune hepatitis
has_exact_synonym: Autoimmune hepatitis (disorder)
id: DOID:2048
has_alternative_id: DOID:4745
database_cross_reference: ICD10CM:K75.4
database_cross_reference: ICD9CM:571.42
database_cross_reference: MSH:D019693
database_cross_reference: NCI:C27029
database_cross_reference: NCI:C27778
database_cross_reference: SNOMEDCT_US_2016_03_01:197284004
database_cross_reference: SNOMEDCT_US_2016_03_01:408335007
database_cross_reference: SNOMEDCT_US_2016_03_01:68784009
database_cross_reference: UMLS_CUI:C0241910
database_cross_reference: UMLS_CUI:C1332355
has_exact_synonym: autoimmune hepatitis with centrilobular necrosis
has_obo_namespace: disease_ontology
definition: An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells.

acute maxillary sinusitis
type: Class
subclass of: maxillary sinusitis
id: DOID:2050
database_cross_reference: ICD10CM:J01.0
database_cross_reference: ICD10CM:J01.00
database_cross_reference: ICD9CM:461.0
database_cross_reference: SNOMEDCT_US_2015_03_01:155499007
database_cross_reference: SNOMEDCT_US_2015_03_01:18714001
database_cross_reference: SNOMEDCT_US_2015_03_01:68272006
database_cross_reference: UMLS_CUI:C0155804
has_exact_synonym: acute antritis
has_obo_namespace: disease_ontology
definition: A maxillary sinusitis which lasts for less than 4 weeks.
imported from: doid.owl

maxillary sinusitis
type: Class
subclass of: sinusitis
id: DOID:2051
database_cross_reference: ICD10CM:J32.0
database_cross_reference: MSH:D015523
database_cross_reference: NCI:C34809
database_cross_reference: SNOMEDCT_US_2015_03_01:275484005
database_cross_reference: SNOMEDCT_US_2015_03_01:88348008
database_cross_reference: UMLS_CUI:C0024959
has_obo_namespace: disease_ontology
definition: A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache.
imported from: doid.owl

hepatitis
type: Class
subclass of: liver disease
has_alternative_id: DOID:12352
has_alternative_id: DOID:14551
has_alternative_id: DOID:1706
has_alternative_id: DOID:1707
id: DOID:2237
has_alternative_id: DOID:2238
database_cross_reference: ICD10CM:K73.9
database_cross_reference: ICD9CM:570
database_cross_reference: ICD9CM:571.4
database_cross_reference: ICD9CM:571.40
database_cross_reference: ICD9CM:571.41
database_cross_reference: MSH:D006521
database_cross_reference: NCI:C82978
database_cross_reference: SNOMEDCT_US_2016_03_01:155808003
database_cross_reference: SNOMEDCT_US_2016_03_01:155813004
database_cross_reference: SNOMEDCT_US_2016_03_01:197268000
database_cross_reference: SNOMEDCT_US_2016_03_01:197278002
database_cross_reference: SNOMEDCT_US_2016_03_01:197288001
database_cross_reference: SNOMEDCT_US_2016_03_01:197289009
database_cross_reference: SNOMEDCT_US_2016_03_01:266536009
database_cross_reference: SNOMEDCT_US_2016_03_01:266539002
database_cross_reference: SNOMEDCT_US_2016_03_01:41889008
database_cross_reference: SNOMEDCT_US_2016_03_01:76783007
database_cross_reference: UMLS_CUI:C0001308
database_cross_reference: UMLS_CUI:C0019189
database_cross_reference: UMLS_CUI:C0149519
has_exact_synonym: acute and subacute liver necrosis
has_exact_synonym: acute and subacute liver necrosis (disorder)
has_exact_synonym: acute and subacute liver necrosis NOS (disorder)
has_exact_synonym: acute and subacute necrosis of liver
has_exact_synonym: acute hepatitis
has_exact_synonym: acute hepatitis (disorder)
has_exact_synonym: acute/subac. necrosis of liver
has_exact_synonym: animal hepatitis
has_exact_synonym: chronic hepatitis
has_exact_synonym: chronic persistent hepatitis
has_obo_namespace: disease_ontology

syndrome
type: Class
subclass of: disease
id: DOID:225
database_cross_reference: MSH:D013577
database_cross_reference: NCI:C28193
database_cross_reference: SNOMEDCT_US_2016_03_01:64572001
database_cross_reference: UMLS_CUI:C0039082
has_obo_namespace: disease_ontology
definition: A disease comprised of a group of signs and symptoms that occur together and characterize a particular abnormality.

female reproductive system disease
type: Class
subclass of: disease
id: DOID:229
database_cross_reference: ICD9CM:629.9
database_cross_reference: MSH:D005831
database_cross_reference: SNOMEDCT_US_2016_03_01:156032001
database_cross_reference: SNOMEDCT_US_2016_03_01:156066005
database_cross_reference: SNOMEDCT_US_2016_03_01:198486002
database_cross_reference: SNOMEDCT_US_2016_03_01:244938009
database_cross_reference: SNOMEDCT_US_2016_03_01:266680004
database_cross_reference: SNOMEDCT_US_2016_03_01:310789003
database_cross_reference: SNOMEDCT_US_2016_03_01:38233001
database_cross_reference: UMLS_CUI:C0017411
has_obo_namespace: disease_ontology
definition: A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes.

anemia
type: Class
subclass of: hematopoietic system disease
id: DOID:2355
database_cross_reference: EFO:0004272
database_cross_reference: ICD10CM:D64.9
database_cross_reference: ICD9CM:285.9
database_cross_reference: MSH:D000740
database_cross_reference: NCI:C2869
comment: PRISM.
database_cross_reference: SNOMEDCT_US_2016_03_01:154786001
database_cross_reference: SNOMEDCT_US_2016_03_01:154812000
database_cross_reference: SNOMEDCT_US_2016_03_01:191277004
database_cross_reference: SNOMEDCT_US_2016_03_01:267531008
database_cross_reference: SNOMEDCT_US_2016_03_01:271737000
database_cross_reference: SNOMEDCT_US_2016_03_01:64593003
database_cross_reference: UMLS_CUI:C0002871
has_exact_synonym: anaemia
has_obo_namespace: disease_ontology
definition: A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.

congenital nervous system abnormality
type: Class
subclass of: physical disorder
id: DOID:2490
database_cross_reference: ICD9CM:742
database_cross_reference: SNOMEDCT_US_2016_03_01:204018008
database_cross_reference: UMLS_CUI:C0158538
has_exact_synonym: congenital neurologic anomaly
has_obo_namespace: disease_ontology

nephrosis
type: Class
subclass of: kidney disease
id: DOID:2527
database_cross_reference: MSH:D009401
database_cross_reference: SNOMEDCT_US_2016_03_01:90708001
database_cross_reference: UMLS_CUI:C0027720
has_obo_namespace: disease_ontology

opiate dependence
type: Class
subclass of: drug dependence
definition: A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.
id: DOID:2559
database_cross_reference: ICD10CM:F11.2
database_cross_reference: ICD9CM:304.0
database_cross_reference: ICD9CM:304.00
database_cross_reference: MSH:D009293
has_exact_synonym: Opioid type dependence
database_cross_reference: SNOMEDCT_US_2016_03_01:191817000
database_cross_reference: SNOMEDCT_US_2016_03_01:191818005
database_cross_reference: SNOMEDCT_US_2016_03_01:192220003
database_cross_reference: SNOMEDCT_US_2016_03_01:75544000
database_cross_reference: UMLS_CUI:C0524662
has_obo_namespace: disease_ontology

Axiom
annotated target: A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Opiate_dependency
annotated source: opiate dependence
annotated property: definition

Axiom
database_cross_reference: ICD9CM_2006:304.0
annotated target: Opioid type dependence
annotated source: opiate dependence
annotated property: has_exact_synonym

morphine dependence
type: Class
subclass of: opiate dependence
definition: An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.
id: DOID:2560
database_cross_reference: MSH:D009021
database_cross_reference: SNOMEDCT_US_2016_03_01:191817000
database_cross_reference: SNOMEDCT_US_2016_03_01:231479000
database_cross_reference: SNOMEDCT_US_2016_03_01:286934009
database_cross_reference: UMLS_CUI:C0026552
has_obo_namespace: disease_ontology

Axiom
annotated target: An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Opioid_dependence
annotated source: morphine dependence
annotated property: definition

barbiturate dependence
type: Class
subclass of: drug dependence
definition: A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance.
id: DOID:2575
database_cross_reference: ICD9CM:304.11
database_cross_reference: SNOMEDCT:231472009
database_cross_reference: UMLS_CUI:C0154482
has_obo_namespace: disease_ontology

Axiom
annotated target: A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Barbiturate_dependence
annotated source: barbiturate dependence
annotated property: definition

endocrine system disease
type: Class
subclass of: disease
id: DOID:28
database_cross_reference: ICD10CM:E34.9
database_cross_reference: ICD9CM:259.9
database_cross_reference: MSH:D004700
database_cross_reference: NCI:C3009
database_cross_reference: SNOMEDCT_US_2016_03_01:118639003
database_cross_reference: SNOMEDCT_US_2016_03_01:127345001
database_cross_reference: SNOMEDCT_US_2016_03_01:154648001
database_cross_reference: SNOMEDCT_US_2016_03_01:154690007
database_cross_reference: SNOMEDCT_US_2016_03_01:154718007
database_cross_reference: SNOMEDCT_US_2016_03_01:190231001
database_cross_reference: SNOMEDCT_US_2016_03_01:190594008
database_cross_reference: SNOMEDCT_US_2016_03_01:267462005
database_cross_reference: SNOMEDCT_US_2016_03_01:267475005
database_cross_reference: SNOMEDCT_US_2016_03_01:267489000
database_cross_reference: SNOMEDCT_US_2016_03_01:362969004
database_cross_reference: SNOMEDCT_US_2016_03_01:67432001
database_cross_reference: UMLS_CUI:C0014130
has_obo_namespace: disease_ontology
definition: A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

immune system disease
type: Class
subclass of: disease
id: DOID:2914
database_cross_reference: EFO:0000540
database_cross_reference: ICD10CM:D89.9
database_cross_reference: ICD9CM:279
database_cross_reference: ICD9CM:279.9
database_cross_reference: SNOMEDCT_US_2016_03_01:154782004
database_cross_reference: SNOMEDCT_US_2016_03_01:191015009
database_cross_reference: SNOMEDCT_US_2016_03_01:191019003
database_cross_reference: SNOMEDCT_US_2016_03_01:191035005
database_cross_reference: UMLS_CUI:C0041806
has_obo_namespace: disease_ontology
definition: A disease of anatomical entity that is located_in the immune system.
in_subset: DO FlyBase slim

cystic kidney disease
type: Class
subclass of: kidney disease
id: DOID:2975
has_exact_synonym: KIDNEY CYST
database_cross_reference: MSH:D052177
database_cross_reference: UMLS_CUI:C0022679
has_obo_namespace: disease_ontology
has_exact_synonym: renal Cyst

food allergy
type: Class
subclass of: allergic hypersensitivity disease
id: DOID:3044
database_cross_reference: MSH:D005512
database_cross_reference: SNOMEDCT_US_2016_03_01:157801005
database_cross_reference: SNOMEDCT_US_2016_03_01:213018006
database_cross_reference: SNOMEDCT_US_2016_03_01:414285001
database_cross_reference: SNOMEDCT_US_2016_03_01:52332009
database_cross_reference: UMLS_CUI:C0016470
has_obo_namespace: disease_ontology
has_exact_synonym: food hypersensitivity
definition: A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system.

uterine disease
type: Class
subclass of: female reproductive system disease
definition: A female reproductive system disease that is located_in the uterus.
id: DOID:345
database_cross_reference: ICD10CM:N85.9
database_cross_reference: ICD9CM:621.9
database_cross_reference: MSH:D014591
database_cross_reference: NCI:C26907
database_cross_reference: SNOMEDCT_US_2016_03_01:12337004
database_cross_reference: SNOMEDCT_US_2016_03_01:156004005
database_cross_reference: SNOMEDCT_US_2016_03_01:156009000
database_cross_reference: SNOMEDCT_US_2016_03_01:198335006
database_cross_reference: SNOMEDCT_US_2016_03_01:237068005
database_cross_reference: UMLS_CUI:C0042131
has_obo_namespace: disease_ontology

intracranial sinus thrombosis
type: Class
subclass of: artery disease
id: DOID:3572
database_cross_reference: MSH:D012851
database_cross_reference: UMLS_CUI:C0037198
has_obo_namespace: disease_ontology
imported from: doid.owl

lateral sinus thrombosis
type: Class
subclass of: intracranial sinus thrombosis
id: DOID:3574
database_cross_reference: MSH:D020227
database_cross_reference: SNOMEDCT_US_2015_03_01:192761004
database_cross_reference: SNOMEDCT_US_2015_03_01:21258007
has_exact_synonym: Thrombosis of lateral venous sinus (disorder)
has_exact_synonym: Thrombosis transverse sinus (disorder)
database_cross_reference: UMLS_CUI:C0270639
has_obo_namespace: disease_ontology
imported from: doid.owl

cavernous sinus thrombosis
type: Class
subclass of: intracranial sinus thrombosis
id: DOID:3575
database_cross_reference: MSH:D020226
database_cross_reference: SNOMEDCT_US_2015_03_01:89980009
has_exact_synonym: Thrombosis of cavernous venous sinus (disorder)
database_cross_reference: UMLS_CUI:C0238454
has_obo_namespace: disease_ontology
imported from: doid.owl

sagittal sinus thrombosis
type: Class
subclass of: intracranial sinus thrombosis
id: DOID:3576
database_cross_reference: MSH:D020225
database_cross_reference: SNOMEDCT_US_2015_03_01:192760003
database_cross_reference: SNOMEDCT_US_2015_03_01:70607008
has_exact_synonym: Thrombosis of superior longitudinal sinus (disorder)
has_exact_synonym: Thrombosis of superior sagittal sinus (disorder)
database_cross_reference: UMLS_CUI:C0338575
has_obo_namespace: disease_ontology
imported from: doid.owl

wheat allergy
type: Class
subclass of: food allergy
id: DOID:3660
database_cross_reference: MSH:D021182
database_cross_reference: SNOMEDCT_US_2016_03_01:420174000
database_cross_reference: UMLS_CUI:C0949570
has_exact_synonym: allergy to wheat
has_obo_namespace: disease_ontology
has_exact_synonym: wheat allergic reaction

placental insufficiency
type: Class
subclass of: placenta disease
definition: A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.
id: DOID:3891
database_cross_reference: MSH:D010927
database_cross_reference: SNOMEDCT_US_2016_03_01:156185006
database_cross_reference: SNOMEDCT_US_2016_03_01:199610002
database_cross_reference: SNOMEDCT_US_2016_03_01:237292005
database_cross_reference: SNOMEDCT_US_2016_03_01:267337006
database_cross_reference: UMLS_CUI:C0032051
has_obo_namespace: disease_ontology

disease
type: Class
id: DOID:4
database_cross_reference: MSH:D004194
database_cross_reference: NCI:C2991
database_cross_reference: SNOMEDCT_US_2015_03_01:64572001
database_cross_reference: UMLS_CUI:C0012634
has_obo_namespace: disease_ontology
definition: A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
imported from: doid.owl

tricuspid valve stenosis
type: Class
subclass of: tricuspid valve disease
id: DOID:4078
database_cross_reference: MSH:D014264
database_cross_reference: NCI:C50783
database_cross_reference: SNOMEDCT_US_2016_03_01:155346002
database_cross_reference: SNOMEDCT_US_2016_03_01:266296006
database_cross_reference: SNOMEDCT_US_2016_03_01:49915006
has_exact_synonym: Tricuspid stenosis
has_exact_synonym: Tricuspid valve stenosis (disorder)
database_cross_reference: UMLS_CUI:C0040963
has_obo_namespace: disease_ontology
definition: A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve.

heart valve disease
type: Class
subclass of: heart disease
id: DOID:4079
has_alternative_id: DOID:989
database_cross_reference: MSH:D006349
database_cross_reference: MSH:D016127
database_cross_reference: NCI:C45525
database_cross_reference: SNOMEDCT_US_2016_03_01:195013005
database_cross_reference: SNOMEDCT_US_2016_03_01:368009
database_cross_reference: SNOMEDCT_US_2016_03_01:398995000
database_cross_reference: UMLS_CUI:C0018824
database_cross_reference: UMLS_CUI:C0079485
has_exact_synonym: Valvular heart disease
has_obo_namespace: disease_ontology
definition: A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right).

tricuspid valve insufficiency
type: Class
subclass of: tricuspid valve disease
id: DOID:4080
database_cross_reference: MSH:D014262
database_cross_reference: NCI:C50842
database_cross_reference: NCI:C50843
database_cross_reference: SNOMEDCT_US_2016_03_01:111287006
database_cross_reference: SNOMEDCT_US_2016_03_01:155347006
database_cross_reference: SNOMEDCT_US_2016_03_01:251009000
database_cross_reference: SNOMEDCT_US_2016_03_01:266298007
has_exact_synonym: Tricuspid incompetence
has_exact_synonym: Tricuspid regurgitation
has_exact_synonym: Tricuspid valve regurgitation (disorder)
database_cross_reference: UMLS_CUI:C0040961
has_obo_namespace: disease_ontology
definition: A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.

liver disease
type: Class
subclass of: gastrointestinal system disease
has_alternative_id: DOID:2164
has_alternative_id: DOID:2165
id: DOID:409
has_alternative_id: DOID:46
database_cross_reference: ICD10CM:K70-K77
database_cross_reference: ICD10CM:K76.9
database_cross_reference: ICD9CM:573.9
database_cross_reference: MSH:D008107
database_cross_reference: NCI:C3196
database_cross_reference: SNOMEDCT_US_2016_03_01:155807008
database_cross_reference: SNOMEDCT_US_2016_03_01:155817003
database_cross_reference: SNOMEDCT_US_2016_03_01:155822003
database_cross_reference: SNOMEDCT_US_2016_03_01:197375001
database_cross_reference: SNOMEDCT_US_2016_03_01:197551000
database_cross_reference: SNOMEDCT_US_2016_03_01:235856003
database_cross_reference: SNOMEDCT_US_2016_03_01:266535008
database_cross_reference: SNOMEDCT_US_2016_03_01:62857009
database_cross_reference: UMLS_CUI:C0023895
has_obo_namespace: disease_ontology
has_exact_synonym: disorder of liver (disorder)
has_exact_synonym: hepatic disorder

syphilis
type: Class
subclass of: bacterial infectious disease
has_alternative_id: DOID:11095
id: DOID:4166
database_cross_reference: ICD10CM:A51.0
database_cross_reference: MSH:D002601
database_cross_reference: SNOMEDCT_US_2016_03_01:266127002
database_cross_reference: SNOMEDCT_US_2016_03_01:58433006
database_cross_reference: UMLS_CUI:C0007939
has_obo_namespace: disease_ontology
has_exact_synonym: syphilitic chancre
definition: A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.
in_subset: gram-negative bacterial infectious disease
in_subset: sexually transmitted infectious disease

hypersensitivity reaction type II disease
type: Class
subclass of: hypersensitivity reaction disease
id: DOID:417
database_cross_reference: ICD9CM:720
database_cross_reference: UMLS_CUI:C0003089
comment: Xref MGI.
has_exact_synonym: autoimmune disease
has_obo_namespace: disease_ontology
definition: An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues.
in_subset: DO MGI slim

hyperglycemia
type: Class
subclass of: disease of metabolism
id: DOID:4195
database_cross_reference: ICD10CM:R73.9
database_cross_reference: MSH:D006943
database_cross_reference: NCI:C26797
database_cross_reference: SNOMEDCT_US_2015_03_01:144187006
database_cross_reference: SNOMEDCT_US_2015_03_01:154719004
database_cross_reference: SNOMEDCT_US_2015_03_01:207289007
database_cross_reference: SNOMEDCT_US_2015_03_01:207643008
database_cross_reference: SNOMEDCT_US_2015_03_01:237598005
database_cross_reference: SNOMEDCT_US_2015_03_01:270004003
database_cross_reference: SNOMEDCT_US_2015_03_01:315299009
database_cross_reference: SNOMEDCT_US_2015_03_01:390730002
database_cross_reference: SNOMEDCT_US_2015_03_01:80394007
database_cross_reference: UMLS_CUI:C0020456
has_obo_namespace: disease_ontology
imported from: doid.owl

milk allergy
type: Class
subclass of: food allergy
id: DOID:4376
database_cross_reference: MSH:D016269
database_cross_reference: UMLS_CUI:C0079840
has_obo_namespace: disease_ontology
has_exact_synonym: milk allergic reaction
definition: A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual.

egg allergy
type: Class
subclass of: food allergy
has_exact_synonym: Allergy to eggs (disorder)
id: DOID:4377
database_cross_reference: MSH:D021181
database_cross_reference: SNOMEDCT_US_2016_03_01:157802003
database_cross_reference: SNOMEDCT_US_2016_03_01:213019003
database_cross_reference: SNOMEDCT_US_2016_03_01:91930004
database_cross_reference: UMLS_CUI:C0559469
has_obo_namespace: disease_ontology
definition: A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms.

peanut allergy
type: Class
subclass of: nut allergy
id: DOID:4378
database_cross_reference: MSH:D021183
database_cross_reference: SNOMEDCT_US_2016_03_01:213021008
database_cross_reference: SNOMEDCT_US_2016_03_01:91935009
database_cross_reference: UMLS_CUI:C0559470
has_exact_synonym: allergy to peanuts
has_obo_namespace: disease_ontology
has_exact_synonym: peanut allergic reaction
definition: A food allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms.

nut allergy
type: Class
subclass of: food allergy
has_exact_synonym: Allergy to nuts (disorder)
has_exact_synonym: Allergy to nuts other than peanuts
id: DOID:4379
database_cross_reference: MSH:D021184
database_cross_reference: SNOMEDCT_US_2016_03_01:395654004
database_cross_reference: SNOMEDCT_US_2016_03_01:91934008
database_cross_reference: UMLS_CUI:C0577620
has_exact_synonym: allergy to nuts
has_obo_namespace: disease_ontology
has_exact_synonym: nut allergic reaction

placenta accreta
type: Class
subclass of: placenta disease
definition: A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.
id: DOID:4744
database_cross_reference: ICD10CM:O43.21
database_cross_reference: MSH:D010921
database_cross_reference: NCI:C26856
database_cross_reference: SNOMEDCT_US_2016_03_01:70129008
database_cross_reference: UMLS_CUI:C0032044
has_obo_namespace: disease_ontology

lymphedema
type: Class
subclass of: lymphatic system disease
id: DOID:4977
has_exact_synonym: Lymphatic edema (morphologic abnormality)
has_exact_synonym: Lymphoedema NOS
database_cross_reference: MSH:D008209
database_cross_reference: NCI:C3207
database_cross_reference: SNOMEDCT_US_2016_03_01:155485008
database_cross_reference: SNOMEDCT_US_2016_03_01:195486001
database_cross_reference: SNOMEDCT_US_2016_03_01:234097001
database_cross_reference: SNOMEDCT_US_2016_03_01:266334008
database_cross_reference: SNOMEDCT_US_2016_03_01:30213001
database_cross_reference: UMLS_CUI:C0024236
has_obo_namespace: disease_ontology

aortic valve prolapse
type: Class
subclass of: aortic valve disease
id: DOID:5232
database_cross_reference: MSH:D001023
database_cross_reference: UMLS_CUI:C0003505
has_obo_namespace: disease_ontology
imported from: doid.owl

human immunodeficiency virus infectious disease
type: Class
subclass of: viral infectious disease
id: DOID:526
has_exact_synonym: HIV infection
has_obo_namespace: disease_ontology
definition: A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.
in_subset: zoonotic infectious disease

pulmonary venoocclusive disease
type: Class
subclass of: pulmonary hypertension
id: DOID:5453
database_cross_reference: MSH:D011668
database_cross_reference: NCI:C85039
comment: OMIM mapping confirmed by DO. [SN].
database_cross_reference: OMIM:265450
database_cross_reference: SNOMEDCT_US_2015_03_01:89420002
database_cross_reference: UMLS_CUI:C0034091
has_obo_namespace: disease_ontology
has_exact_synonym: pulmonary veno-occlusive disease (disorder)
imported from: doid.owl

kidney disease
type: Class
subclass of: urinary system disease
id: DOID:557
database_cross_reference: EFO:0003086
database_cross_reference: ICD10CM:N08
database_cross_reference: ICD10CM:N28.9
database_cross_reference: MSH:D007674
database_cross_reference: NCI:C3149
database_cross_reference: NCI:C34843
database_cross_reference: SNOMEDCT_US_2016_03_01:155871008
database_cross_reference: SNOMEDCT_US_2016_03_01:266612003
database_cross_reference: SNOMEDCT_US_2016_03_01:266624005
database_cross_reference: SNOMEDCT_US_2016_03_01:266627003
database_cross_reference: SNOMEDCT_US_2016_03_01:274108006
database_cross_reference: SNOMEDCT_US_2016_03_01:90708001
database_cross_reference: UMLS_CUI:C0022658
has_obo_namespace: disease_ontology
has_exact_synonym: nephropathy
definition: A urinary system disease that is located_in the kidney.
in_subset: DO FlyBase slim

tricuspid valve prolapse
type: Class
subclass of: tricuspid valve disease
id: DOID:5644
database_cross_reference: MSH:D014263
database_cross_reference: SNOMEDCT_US_2016_03_01:253383003
has_exact_synonym: Tricuspid valve prolapse (disorder)
database_cross_reference: UMLS_CUI:C0040962
has_obo_namespace: disease_ontology

aortic valve insufficiency
type: Class
subclass of: aortic valve disease
definition: An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle.
has_related_synonym: Corrigan's disease
has_alternative_id: DOID:54
has_alternative_id: DOID:55
id: DOID:57
database_cross_reference: ICD10CM:I06.1
database_cross_reference: ICD9CM:395.1
database_cross_reference: ICD9CM:396.3
database_cross_reference: MSH:D001022
database_cross_reference: NCI:C50861
database_cross_reference: NCI:C51223
has_exact_synonym: Rheumatic aortic insufficiency
has_exact_synonym: Rheumatic aortic regurgitation
has_exact_synonym: Rheumatic aortic valve regurgitation
database_cross_reference: SNOMEDCT_US_2015_03_01:155283004
database_cross_reference: SNOMEDCT_US_2015_03_01:194736003
database_cross_reference: SNOMEDCT_US_2015_03_01:60234000
database_cross_reference: SNOMEDCT_US_2015_03_01:78031003
database_cross_reference: UMLS_CUI:C0003504
database_cross_reference: UMLS_CUI:C0155568
database_cross_reference: UMLS_CUI:C0264774
has_exact_synonym: aortic incompetence
has_exact_synonym: aortic insufficiency
has_exact_synonym: aortic regurgitation
has_obo_namespace: disease_ontology
has_exact_synonym: rheumatic aortic valve insufficiency
imported from: doid.owl

rheumatic pulmonary valve disease
type: Class
subclass of: pulmonary valve disease
id: DOID:5748
database_cross_reference: ICD10CM:I09.89
database_cross_reference: ICD9CM:397.1
has_exact_synonym: Rheumatic disease of pulmonary valve
has_exact_synonym: Rheumatic disease of pulmonary valve (disorder)
has_exact_synonym: Rheumatic pulmonary incompetence
has_exact_synonym: Rheumatic pulmonary valve disease NOS (disorder)
database_cross_reference: SNOMEDCT_US_2015_03_01:18687009
database_cross_reference: SNOMEDCT_US_2015_03_01:194747005
database_cross_reference: SNOMEDCT_US_2015_03_01:266283005
database_cross_reference: UMLS_CUI:C0155579
has_obo_namespace: disease_ontology
imported from: doid.owl

pulmonary valve disease
type: Class
subclass of: heart valve disease
id: DOID:5749
database_cross_reference: ICD9CM:424.3
database_cross_reference: NCI:C78579
database_cross_reference: SNOMEDCT_US_2015_03_01:195001000
database_cross_reference: SNOMEDCT_US_2015_03_01:76267008
database_cross_reference: SNOMEDCT_US_2016_03_01:195001000
database_cross_reference: SNOMEDCT_US_2016_03_01:76267008
database_cross_reference: UMLS_CUI:C0034087
has_obo_namespace: disease_ontology
has_exact_synonym: pulmonary valve disorder
imported from: doid.owl

discrete subaortic stenosis
type: Class
subclass of: subvalvular aortic stenosis
id: DOID:5804
database_cross_reference: MSH:D021922
database_cross_reference: UMLS_CUI:C0012628
has_obo_namespace: disease_ontology
imported from: doid.owl

subvalvular aortic stenosis
type: Class
subclass of: aortic valve stenosis
id: DOID:5805
database_cross_reference: MSH:D001020
database_cross_reference: NCI:C85172
database_cross_reference: UMLS_CUI:C0003500
has_obo_namespace: disease_ontology
imported from: doid.owl

congestive heart failure
type: Class
subclass of: heart disease
has_exact_synonym: CHF
has_exact_synonym: Cardiac Failure Congestive
has_exact_synonym: Congestive heart disease
has_alternative_id: DOID:395
id: DOID:6000
database_cross_reference: ICD10CM:I50
database_cross_reference: ICD10CM:I50.9
database_cross_reference: ICD9CM:428
database_cross_reference: ICD9CM:428.0
database_cross_reference: ICD9CM:428.9
database_cross_reference: MSH:D006333
database_cross_reference: NCI:C3080
database_cross_reference: NCI:C50577
database_cross_reference: SNOMEDCT_US_2016_03_01:155374007
database_cross_reference: SNOMEDCT_US_2016_03_01:155375008
database_cross_reference: SNOMEDCT_US_2016_03_01:155377000
database_cross_reference: SNOMEDCT_US_2016_03_01:195108009
database_cross_reference: SNOMEDCT_US_2016_03_01:195117009
database_cross_reference: SNOMEDCT_US_2016_03_01:266248006
database_cross_reference: SNOMEDCT_US_2016_03_01:266308000
database_cross_reference: SNOMEDCT_US_2016_03_01:42343007
database_cross_reference: SNOMEDCT_US_2016_03_01:84114007
database_cross_reference: UMLS_CUI:C0018801
database_cross_reference: UMLS_CUI:C0018802
has_exact_synonym: Weak heart
has_obo_namespace: disease_ontology
definition: A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.

mitral valve disease
type: Class
subclass of: heart valve disease
has_alternative_id: DOID:11505
has_alternative_id: DOID:58
has_alternative_id: DOID:59
id: DOID:61
database_cross_reference: ICD10CM:I05
database_cross_reference: ICD10CM:I05.1
database_cross_reference: ICD10CM:I05.9
database_cross_reference: ICD9CM:394
database_cross_reference: ICD9CM:394.1
database_cross_reference: ICD9CM:424.0
has_exact_synonym: Mitral RH valve dis.
database_cross_reference: NCI:C78446
has_exact_synonym: Rheumatic disease of mitral valve (disorder)
has_exact_synonym: Rheumatic mitral insufficiency
has_exact_synonym: Rheumatic mitral valve changes
has_exact_synonym: Rheumatic mitral valve regurgitation
database_cross_reference: SNOMEDCT_US_2016_03_01:11851006
database_cross_reference: SNOMEDCT_US_2016_03_01:155276006
database_cross_reference: SNOMEDCT_US_2016_03_01:155278007
database_cross_reference: SNOMEDCT_US_2016_03_01:155279004
database_cross_reference: SNOMEDCT_US_2016_03_01:194724009
database_cross_reference: SNOMEDCT_US_2016_03_01:194729004
database_cross_reference: SNOMEDCT_US_2016_03_01:194982000
database_cross_reference: SNOMEDCT_US_2016_03_01:250998008
database_cross_reference: SNOMEDCT_US_2016_03_01:266278002
database_cross_reference: SNOMEDCT_US_2016_03_01:266279005
database_cross_reference: SNOMEDCT_US_2016_03_01:31085000
database_cross_reference: SNOMEDCT_US_2016_03_01:83898004
database_cross_reference: UMLS_CUI:C0026265
database_cross_reference: UMLS_CUI:C0155563
database_cross_reference: UMLS_CUI:C0264765
has_exact_synonym: chronic rheumatic mitral valve (disorder)
has_exact_synonym: disease of mitral valve
has_obo_namespace: disease_ontology
has_exact_synonym: rheumatic disease of mitral valve
has_exact_synonym: rheumatic mitral valve incompetence

primary immunodeficiency disease
type: Class
subclass of: immune system disease
id: DOID:612
database_cross_reference: ICD10CM:D84.9
database_cross_reference: ICD9CM:279.3
database_cross_reference: KEGG:05340
database_cross_reference: MSH:D007153
database_cross_reference: NCI:C3131
database_cross_reference: NCI:C39725
database_cross_reference: OMIM:242850
database_cross_reference: SNOMEDCT_US_2016_03_01:191005003
database_cross_reference: SNOMEDCT_US_2016_03_01:234532001
database_cross_reference: SNOMEDCT_US_2016_03_01:64431000
database_cross_reference: UMLS_CUI:C0021051
comment: Xref MGI.
has_obo_namespace: disease_ontology
has_exact_synonym: hypoimmunity
has_exact_synonym: immune deficiency disorder
has_exact_synonym: immunodeficiency syndrome
definition: An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.
in_subset: DO FlyBase slim
in_subset: DO MGI slim

aortic valve disease
type: Class
subclass of: heart valve disease
has_alternative_id: DOID:56
id: DOID:62
database_cross_reference: ICD9CM:395
database_cross_reference: ICD9CM:424.1
database_cross_reference: MSH:C563178
database_cross_reference: NCI:C78650
database_cross_reference: SNOMEDCT_US_2015_03_01:194988001
database_cross_reference: SNOMEDCT_US_2015_03_01:8722008
database_cross_reference: UMLS_CUI:C1260873
comment: Updating out dated UMLS CUI.
has_obo_namespace: disease_ontology
imported from: doid.owl

pulmonary valve stenosis
type: Class
subclass of: pulmonary valve disease
id: DOID:6420
database_cross_reference: MSH:D011666
database_cross_reference: SNOMEDCT_US_2015_03_01:56786000
database_cross_reference: UMLS_CUI:C0034089
has_obo_namespace: disease_ontology
imported from: doid.owl

pulmonary hypertension
type: Class
subclass of: hypertension
id: DOID:6432
database_cross_reference: ICD10CM:I27.2
database_cross_reference: MSH:D006976
database_cross_reference: NCI:C3120
database_cross_reference: SNOMEDCT_US_2015_03_01:155328008
database_cross_reference: SNOMEDCT_US_2015_03_01:266293003
database_cross_reference: SNOMEDCT_US_2015_03_01:70995007
database_cross_reference: UMLS_CUI:C0020542
has_obo_namespace: disease_ontology
definition: A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.
imported from: doid.owl

premenstrual tension
type: Class
subclass of: female reproductive system disease
id: DOID:727
database_cross_reference: ICD10CM:N94.3
database_cross_reference: ICD9CM:625.4
database_cross_reference: MSH:D011293
database_cross_reference: SNOMEDCT_US_2016_03_01:123076003
database_cross_reference: SNOMEDCT_US_2016_03_01:156026006
database_cross_reference: SNOMEDCT_US_2016_03_01:198407008
database_cross_reference: SNOMEDCT_US_2016_03_01:82639001
database_cross_reference: UMLS_CUI:C0376356
has_obo_namespace: disease_ontology

hematopoietic system disease
type: Class
subclass of: immune system disease
has_exact_synonym: Blood disease
has_exact_synonym: Blood dyscrasia NOS
has_exact_synonym: DISEASE OF THE BLOOD AND BLOOD-FORMING ORGANS
id: DOID:74
has_exact_synonym: Hematological disease
database_cross_reference: ICD10CM:D75.9
database_cross_reference: ICD9CM:280-289.99
database_cross_reference: ICD9CM:289.9
database_cross_reference: MSH:D006402
database_cross_reference: NCI:C26323
database_cross_reference: SNOMEDCT_US_2016_03_01:154785002
database_cross_reference: SNOMEDCT_US_2016_03_01:154842002
database_cross_reference: SNOMEDCT_US_2016_03_01:191124002
database_cross_reference: SNOMEDCT_US_2016_03_01:191402006
database_cross_reference: SNOMEDCT_US_2016_03_01:191446003
database_cross_reference: SNOMEDCT_US_2016_03_01:267552000
database_cross_reference: SNOMEDCT_US_2016_03_01:267573000
database_cross_reference: SNOMEDCT_US_2016_03_01:34093004
database_cross_reference: UMLS_CUI:C0018939
has_exact_synonym: blood disorder
has_exact_synonym: disease of hematopoietic system
has_obo_namespace: disease_ontology
definition: An immune system disease that has_material_basis_in hematopoietic cells.

lymphatic system disease
type: Class
subclass of: immune system disease
has_exact_synonym: Adenopathy
id: DOID:75
has_exact_synonym: Lymphangiopathy, NOS
has_exact_synonym: Lymphatic disease
has_exact_synonym: Lymphatic disorder
database_cross_reference: MSH:D008206
database_cross_reference: SNOMEDCT_US_2016_03_01:111590001
database_cross_reference: SNOMEDCT_US_2016_03_01:155452000
database_cross_reference: SNOMEDCT_US_2016_03_01:234087005
database_cross_reference: SNOMEDCT_US_2016_03_01:266326002
database_cross_reference: SNOMEDCT_US_2016_03_01:3305006
database_cross_reference: SNOMEDCT_US_2016_03_01:362971004
database_cross_reference: UMLS_CUI:C0024228
has_exact_synonym: disease of lympoid system
has_obo_namespace: disease_ontology
has_exact_synonym: disorder of lymph node and lymphatics (disorder)
has_exact_synonym: disorder of lymphatic system
has_exact_synonym: disorder of lymphoid system
has_exact_synonym: lymphatic disorder
has_exact_synonym: lympoid system disease
definition: An immune system disease that is located_in the lymphatic system.

gastrointestinal system disease
type: Class
subclass of: disease
has_alternative_id: DOID:27
id: DOID:77
has_alternative_id: DOID:944
has_exact_synonym: GIT disease
has_exact_synonym: Gastroenteropathy
database_cross_reference: ICD10CM:K92.9
database_cross_reference: ICD9CM:520-579.99
database_cross_reference: MSH:D004066
database_cross_reference: SNOMEDCT_US_2016_03_01:155629009
database_cross_reference: SNOMEDCT_US_2016_03_01:155847001
database_cross_reference: SNOMEDCT_US_2016_03_01:197575000
database_cross_reference: SNOMEDCT_US_2016_03_01:266483008
database_cross_reference: SNOMEDCT_US_2016_03_01:53619000
database_cross_reference: UMLS_CUI:C0012242
has_exact_synonym: alimentary system disease
has_exact_synonym: digestive system disorder
has_obo_namespace: disease_ontology
has_exact_synonym: gastrointestinal disease
has_exact_synonym: gastrointestinal disorder
definition: A disease of anatomical entity that is located_in the gastrointestinal tract.

placenta disease
type: Class
subclass of: uterine disease
definition: A uterine disease that is located_in the placenta.
has_alternative_id: DOID:1815
has_alternative_id: DOID:5366
id: DOID:780
has_alternative_id: DOID:9219
database_cross_reference: ICD10CM:O43
database_cross_reference: ICD10CM:O43.9
database_cross_reference: ICD10CM:O43.90
database_cross_reference: ICD9CM:646.9
database_cross_reference: MSH:D010922
database_cross_reference: MSH:D011248
database_cross_reference: NCI:C26857
database_cross_reference: NCI:C27619
database_cross_reference: NCI:C34941
database_cross_reference: NCI:C35169
database_cross_reference: SNOMEDCT_US_2016_03_01:125586008
database_cross_reference: SNOMEDCT_US_2016_03_01:156069003
database_cross_reference: SNOMEDCT_US_2016_03_01:156097009
database_cross_reference: SNOMEDCT_US_2016_03_01:156123001
database_cross_reference: SNOMEDCT_US_2016_03_01:156131006
database_cross_reference: SNOMEDCT_US_2016_03_01:172422001
database_cross_reference: SNOMEDCT_US_2016_03_01:173300003
database_cross_reference: SNOMEDCT_US_2016_03_01:198881004
database_cross_reference: SNOMEDCT_US_2016_03_01:199152008
database_cross_reference: SNOMEDCT_US_2016_03_01:23288008
database_cross_reference: SNOMEDCT_US_2016_03_01:267293009
database_cross_reference: SNOMEDCT_US_2016_03_01:267311008
database_cross_reference: SNOMEDCT_US_2016_03_01:267314000
database_cross_reference: SNOMEDCT_US_2016_03_01:90821003
database_cross_reference: UMLS_CUI:C0032045
database_cross_reference: UMLS_CUI:C0032962
database_cross_reference: UMLS_CUI:C0151864
database_cross_reference: UMLS_CUI:C1335423
has_obo_namespace: disease_ontology

nervous system disease
type: Class
subclass of: disease
definition: A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.
database_cross_reference: ICD10CM:G00-G99
database_cross_reference: ICD10CM:G98
database_cross_reference: ICD10CM:G98.8
database_cross_reference: ICD9CM:349.9
database_cross_reference: MSH:D009422
database_cross_reference: NCI:C26835
database_cross_reference: SNOMEDCT_US_2016_03_01:118940003
database_cross_reference: SNOMEDCT_US_2016_03_01:154981003
database_cross_reference: SNOMEDCT_US_2016_03_01:155262005
database_cross_reference: SNOMEDCT_US_2016_03_01:192641002
database_cross_reference: SNOMEDCT_US_2016_03_01:267679005
database_cross_reference: SNOMEDCT_US_2016_03_01:286946008
database_cross_reference: UMLS_CUI:C0027765
has_obo_namespace: disease_ontology
id: DOID:863

Axiom
annotated source: nervous system disease
annotated property: definition
annotated target: A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.
database_cross_reference: url:http://en.wikipedia.org/wiki/Nervous_system

migraine
type: Class
subclass of: nervous system disease
definition: A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.
has_alternative_id: DOID:12437
database_cross_reference: EFO:0003821
database_cross_reference: ICD10CM:G43
database_cross_reference: ICD10CM:G43.9
database_cross_reference: ICD10CM:G43.909
database_cross_reference: ICD9CM:346
database_cross_reference: ICD9CM:346.9
database_cross_reference: MSH:D008881
database_cross_reference: NCI:C89715
database_cross_reference: OMIM:157300
database_cross_reference: OMIM:613656
database_cross_reference: SNOMEDCT_US_2016_03_01:155046006
database_cross_reference: SNOMEDCT_US_2016_03_01:155048007
database_cross_reference: SNOMEDCT_US_2016_03_01:193030005
database_cross_reference: SNOMEDCT_US_2016_03_01:193036004
database_cross_reference: SNOMEDCT_US_2016_03_01:193041007
database_cross_reference: SNOMEDCT_US_2016_03_01:267699004
database_cross_reference: SNOMEDCT_US_2016_03_01:37796009
database_cross_reference: UMLS_CUI:C0042331
database_cross_reference: UMLS_CUI:C0149931
has_exact_synonym: migraine disorder
has_exact_synonym: migraine variant
has_exact_synonym: migraine with or without aura
has_obo_namespace: disease_ontology
id: DOID:6364
in_subset: DO MGI slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

Axiom
annotated source: migraine
annotated property: definition
annotated target: A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.
database_cross_reference: url:http://en.wikipedia.org/wiki/Migraine
database_cross_reference: url:http://www.mayoclinic.com/health/migraine-headache/DS00120

epilepsy
type: Class
subclass of: nervous system disease
definition: A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.
database_cross_reference: EFO:0000474
database_cross_reference: ICD10CM:G40.9
database_cross_reference: ICD10CM:G40.909
database_cross_reference: ICD9CM:345.9
database_cross_reference: MSH:D004827
database_cross_reference: NCI:C3020
database_cross_reference: SNOMEDCT_US_2016_03_01:128613002
database_cross_reference: SNOMEDCT_US_2016_03_01:155036009
database_cross_reference: SNOMEDCT_US_2016_03_01:155045005
database_cross_reference: SNOMEDCT_US_2016_03_01:193026007
database_cross_reference: SNOMEDCT_US_2016_03_01:246545002
database_cross_reference: SNOMEDCT_US_2016_03_01:267593008
database_cross_reference: SNOMEDCT_US_2016_03_01:267698007
database_cross_reference: SNOMEDCT_US_2016_03_01:271788002
database_cross_reference: SNOMEDCT_US_2016_03_01:313307000
database_cross_reference: SNOMEDCT_US_2016_03_01:84757009
database_cross_reference: UMLS_CUI:C0014544
has_exact_synonym: epilepsy syndrome
has_exact_synonym: epileptic syndrome
has_obo_namespace: disease_ontology
id: DOID:1826
in_subset: DO FlyBase slim

Axiom
annotated source: epilepsy
annotated property: definition
annotated target: A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.
database_cross_reference: url:http://www.merriam-webster.com/medlineplus/epilepsy

dystonia
type: Class
subclass of: nervous system disease
has_alternative_id: DOID:544
database_cross_reference: ICD10CM:G24
database_cross_reference: ICD10CM:G24.9
database_cross_reference: MSH:D004421
database_cross_reference: MSH:D020821
database_cross_reference: NCI:C34563
database_cross_reference: SNOMEDCT_US_2016_03_01:15802004
database_cross_reference: SNOMEDCT_US_2016_03_01:192863009
database_cross_reference: SNOMEDCT_US_2016_03_01:194478005
database_cross_reference: SNOMEDCT_US_2016_03_01:250068003
database_cross_reference: UMLS_CUI:C0013421
database_cross_reference: UMLS_CUI:C0393593
has_exact_synonym: dystonic disease
has_obo_namespace: disease_ontology
id: DOID:543
in_subset: DO FlyBase slim

hyperthyroidism
type: Class
subclass of: endocrine system disease
id: DOID:7998
database_cross_reference: ICD10CM:E05.9
database_cross_reference: MSH:D006980
database_cross_reference: NCI:C3123
database_cross_reference: OMIM:603373
database_cross_reference: OMIM:609152
database_cross_reference: ORDO:99819
database_cross_reference: SNOMEDCT_US_2016_03_01:154655004
database_cross_reference: SNOMEDCT_US_2016_03_01:190239004
database_cross_reference: SNOMEDCT_US_2016_03_01:267464006
database_cross_reference: SNOMEDCT_US_2016_03_01:34486009
database_cross_reference: UMLS_CUI:C0020550
comment: Xref MGI.
has_obo_namespace: disease_ontology
has_exact_synonym: overactive thyroid
definition: A thyroid gland disease that involves an over production of thyroid hormone.
in_subset: DO MGI slim

pulmonary subvalvular stenosis
type: Class
subclass of: pulmonary valve stenosis
has_exact_synonym: Congenital Infundibular Stenosis
id: DOID:8861
database_cross_reference: ICD10CM:Q24.3
database_cross_reference: ICD9CM:746.83
has_exact_synonym: Infundibular pulmonic stenosis (disorder)
has_exact_synonym: Infundibular pulmonic stenosis, congenital
database_cross_reference: MSH:D011662
database_cross_reference: NCI:C34961
database_cross_reference: SNOMEDCT_US_2015_03_01:204370002
database_cross_reference: SNOMEDCT_US_2015_03_01:3192005
has_exact_synonym: Subvalvular pulmonic stenosis
database_cross_reference: UMLS_CUI:C0034084
has_obo_namespace: disease_ontology
has_exact_synonym: pulmonary infundibular stenosis (disorder)
imported from: doid.owl

chronic ethmoiditis
type: Class
subclass of: ethmoid sinusitis
id: DOID:9312
database_cross_reference: ICD10CM:J32.2
database_cross_reference: ICD9CM:473.2
database_cross_reference: NCI:C34472
database_cross_reference: SNOMEDCT_US_2015_03_01:155528009
database_cross_reference: SNOMEDCT_US_2015_03_01:266384001
database_cross_reference: SNOMEDCT_US_2015_03_01:73237007
database_cross_reference: UMLS_CUI:C0008681
has_exact_synonym: chronic ethmoid sinusitis
has_exact_synonym: chronic ethmoidal sinusitis
has_obo_namespace: disease_ontology
has_exact_synonym: ethmoidal sinusitis - chronic
definition: A ethmoid sinusitis which lasts for 12 weeks or more.
imported from: doid.owl

pain agnosia
type: Class
subclass of: agnosia
definition: An agnosia that is a loss of the ability to perceive and process pain.
created by: lschriml
creation date: 2011-08-22T12:04:56Z
has_exact_synonym: analgesia
has_obo_namespace: disease_ontology
id: DOID:0060145

sexual disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involves the impairment in normal sexual functioning.
has_obo_namespace: disease_ontology
id: DOID:0060043

sexual dysfunction
type: Class
subclass of: sexual disorder
database_cross_reference: ICD10CM:F52.9
database_cross_reference: ICD10CM:R37
database_cross_reference: NCI:C3347
database_cross_reference: SNOMEDCT_US_2016_03_01:225723003
database_cross_reference: SNOMEDCT_US_2016_03_01:231532002
database_cross_reference: SNOMEDCT_US_2016_03_01:39894007
database_cross_reference: SNOMEDCT_US_2016_03_01:56925008
database_cross_reference: SNOMEDCT_US_2016_03_01:65655009
database_cross_reference: UMLS_CUI:C0549622
has_exact_synonym: abnormal sexual function (finding)
has_obo_namespace: disease_ontology
id: DOID:1876

agnosia
type: Class
subclass of: disease of mental health
definition: A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.
has_alternative_id: DOID:4019
database_cross_reference: ICD10CM:R48.1
database_cross_reference: ICD10CM:R48.2
database_cross_reference: MSH:D000377
database_cross_reference: MSH:D001072
database_cross_reference: NCI:C84542
database_cross_reference: SNOMEDCT_US_2016_03_01:158320000
database_cross_reference: SNOMEDCT_US_2016_03_01:158322008
database_cross_reference: SNOMEDCT_US_2016_03_01:192146008
database_cross_reference: SNOMEDCT_US_2016_03_01:206989009
database_cross_reference: SNOMEDCT_US_2016_03_01:206991001
database_cross_reference: SNOMEDCT_US_2016_03_01:250058008
database_cross_reference: SNOMEDCT_US_2016_03_01:271724003
database_cross_reference: SNOMEDCT_US_2016_03_01:42341009
database_cross_reference: SNOMEDCT_US_2016_03_01:68345001
database_cross_reference: SNOMEDCT_US_2016_03_01:6950007
database_cross_reference: UMLS_CUI:C0001816
database_cross_reference: UMLS_CUI:C0003635
has_exact_synonym: Dyspraxia (finding)
has_exact_synonym: Dyspraxia syndrome
has_obo_namespace: disease_ontology
id: DOID:4090

viral infectious disease
type: Class
subclass of: disease
has_alternative_id: DOID:1329
id: DOID:934
has_exact_synonym: Viral Infection
has_exact_synonym: Viral disease
has_exact_synonym: Viral disease (disorder)
has_exact_synonym: Viral infection NOS
has_exact_synonym: Viral infection NOS (disorder)
has_exact_synonym: Viral infection, unspecified (disorder)
has_exact_synonym: Viral: [infection NOS] or [illness]
has_related_synonym: arthropod-borne viruses
has_exact_synonym: virus infection
definition: A disease by infectious agent that results_in infection, has_material_basis_in Viruses.
in_subset: DO FlyBase slim

diabetes mellitus
type: Class
subclass of: disease of metabolism
id: DOID:9351
database_cross_reference: ICD10CM:E08-E13
database_cross_reference: ICD10CM:E11
database_cross_reference: ICD9CM:250
database_cross_reference: MSH:D003920
database_cross_reference: NCI:C2985
database_cross_reference: SNOMEDCT_US_2015_03_01:154671004
database_cross_reference: SNOMEDCT_US_2015_03_01:191044006
database_cross_reference: SNOMEDCT_US_2015_03_01:267467004
database_cross_reference: SNOMEDCT_US_2015_03_01:73211009
database_cross_reference: UMLS_CUI:C0011849
has_obo_namespace: disease_ontology
definition: A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
imported from: doid.owl

type 2 diabetes mellitus
type: Class
subclass of: diabetes mellitus
id: DOID:9352
database_cross_reference: EFO:0001360
database_cross_reference: ICD10CM:E11
database_cross_reference: KEGG:04930
database_cross_reference: MSH:D003924
database_cross_reference: NCI:C26747
has_exact_synonym: NIDDM
database_cross_reference: OMIM:125853
database_cross_reference: OMIM:601283
database_cross_reference: OMIM:601407
database_cross_reference: OMIM:603694
database_cross_reference: OMIM:608036
database_cross_reference: SNOMEDCT_US_2015_03_01:154672006
database_cross_reference: SNOMEDCT_US_2015_03_01:190323008
database_cross_reference: SNOMEDCT_US_2015_03_01:190384004
database_cross_reference: SNOMEDCT_US_2015_03_01:267468009
database_cross_reference: SNOMEDCT_US_2015_03_01:44054006
database_cross_reference: UMLS_CUI:C0011860
has_obo_namespace: disease_ontology
has_exact_synonym: non-insulin-dependent diabetes mellitus
has_exact_synonym: type II diabetes mellitus
definition: A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.
imported from: doid.owl
in_subset: DO MGI slim

acute ethmoiditis
type: Class
subclass of: ethmoid sinusitis
id: DOID:9506
database_cross_reference: ICD10CM:J01.2
database_cross_reference: ICD10CM:J01.20
database_cross_reference: ICD9CM:461.2
database_cross_reference: SNOMEDCT_US_2015_03_01:155501004
database_cross_reference: SNOMEDCT_US_2015_03_01:266378004
database_cross_reference: SNOMEDCT_US_2015_03_01:67832005
database_cross_reference: UMLS_CUI:C0155806
has_exact_synonym: acute ethmoid sinusitis
has_exact_synonym: acute ethmoidal sinusitis
has_obo_namespace: disease_ontology
has_exact_synonym: ethmoidal sinus - acute
definition: A ethmoid sinusitis which lasts for less than 4 weeks.
imported from: doid.owl

ethmoid sinusitis
type: Class
subclass of: sinusitis
id: DOID:9507
database_cross_reference: ICD10CM:J32.2
database_cross_reference: MSH:D015521
database_cross_reference: NCI:C34597
database_cross_reference: SNOMEDCT_US_2015_03_01:18643000
database_cross_reference: UMLS_CUI:C0015029
has_obo_namespace: disease_ontology
has_exact_synonym: ethmoidal sinusitis
has_exact_synonym: ethmoiditis
definition: A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead.
imported from: doid.owl

adrenal gland disease
type: Class
subclass of: endocrine system disease
id: DOID:9553
database_cross_reference: ICD10CM:E27.9
database_cross_reference: ICD9CM:255
database_cross_reference: ICD9CM:255.9
database_cross_reference: MSH:D000307
database_cross_reference: NCI:C26690
database_cross_reference: SNOMEDCT_US_2016_03_01:154704000
database_cross_reference: SNOMEDCT_US_2016_03_01:190532009
database_cross_reference: SNOMEDCT_US_2016_03_01:30171000
database_cross_reference: UMLS_CUI:C0001621
has_obo_namespace: disease_ontology
definition: An endocrine system disease that is located_in the adrenal gland.

type 1 diabetes mellitus
type: Class
subclass of: diabetes mellitus
id: DOID:9744
database_cross_reference: EFO:0001359
database_cross_reference: ICD10CM:E10
has_exact_synonym: IDDM
database_cross_reference: KEGG:04940
database_cross_reference: MSH:D003922
database_cross_reference: NCI:C2986
database_cross_reference: OMIM:125852
database_cross_reference: OMIM:222100
database_cross_reference: OMIM:300136
database_cross_reference: OMIM:600318
database_cross_reference: OMIM:600319
database_cross_reference: OMIM:600320
database_cross_reference: OMIM:600321
database_cross_reference: OMIM:600883
database_cross_reference: OMIM:601208
database_cross_reference: OMIM:601318
database_cross_reference: OMIM:601388
database_cross_reference: OMIM:601666
database_cross_reference: OMIM:601941
database_cross_reference: OMIM:601942
database_cross_reference: OMIM:603266
database_cross_reference: OMIM:605598
database_cross_reference: OMIM:610155
database_cross_reference: OMIM:612520
database_cross_reference: OMIM:612521
database_cross_reference: OMIM:612522
database_cross_reference: OMIM:612622
database_cross_reference: OMIM:613006
database_cross_reference: SNOMEDCT_US_2015_03_01:154673001
database_cross_reference: SNOMEDCT_US_2015_03_01:190322003
database_cross_reference: SNOMEDCT_US_2015_03_01:190362004
database_cross_reference: SNOMEDCT_US_2015_03_01:267469001
database_cross_reference: SNOMEDCT_US_2015_03_01:46635009
database_cross_reference: UMLS_CUI:C0011854
has_obo_namespace: disease_ontology
has_exact_synonym: insulin-dependent diabetes mellitus
has_exact_synonym: type I diabetes mellitus
definition: A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.
imported from: doid.owl
in_subset: DO MGI slim

heart aneurysm
type: Class
subclass of: heart disease
id: DOID:9768
database_cross_reference: ICD10CM:I25.3
database_cross_reference: MSH:D006322
database_cross_reference: SNOMEDCT_US_2016_03_01:155317009
database_cross_reference: SNOMEDCT_US_2016_03_01:194847002
database_cross_reference: SNOMEDCT_US_2016_03_01:65340007
database_cross_reference: UMLS_CUI:C0018789
has_exact_synonym: cardiac aneurysm
has_obo_namespace: disease_ontology

mitral valve prolapse
type: Class
subclass of: mitral valve disease
definition: A mitral valve disease where one or both of the cusps of the mitral valve bulge or collapse backward in the left atrium during systole.
has_exact_synonym: Barlow's syndrome
id: DOID:988
database_cross_reference: MSH:D008945
database_cross_reference: NCI:C50655
database_cross_reference: OMIM:157700
database_cross_reference: OMIM:607829
database_cross_reference: OMIM:610840
database_cross_reference: SNOMEDCT_US_2016_03_01:155386005
database_cross_reference: SNOMEDCT_US_2016_03_01:194977007
database_cross_reference: SNOMEDCT_US_2016_03_01:194980008
database_cross_reference: SNOMEDCT_US_2016_03_01:409712001
database_cross_reference: SNOMEDCT_US_2016_03_01:42069006
database_cross_reference: SNOMEDCT_US_2016_03_01:45023003
database_cross_reference: SNOMEDCT_US_2016_03_01:8074002
database_cross_reference: UMLS_CUI:C0026267
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].
has_obo_namespace: disease_ontology
has_exact_synonym: floppy mitral valve
has_related_synonym: mitral leaflet syndrome
has_related_synonym: myxomatous mitral valve prolapse
has_related_synonym: systolic click-murmur syndrome
in_subset: DO MGI slim

toxoplasmosis
type: Class
subclass of: parasitic infectious disease
has_alternative_id: DOID:13334
has_alternative_id: DOID:13339
has_alternative_id: DOID:13344
id: DOID:9965
database_cross_reference: ICD10CM:B58
database_cross_reference: ICD10CM:B58.9
database_cross_reference: ICD9CM:130
database_cross_reference: ICD9CM:130.9
database_cross_reference: MSH:D014123
database_cross_reference: NCI:C3418
database_cross_reference: SNOMEDCT_US_2016_03_01:154423006
database_cross_reference: SNOMEDCT_US_2016_03_01:187192000
database_cross_reference: SNOMEDCT_US_2016_03_01:187200007
database_cross_reference: SNOMEDCT_US_2016_03_01:187515009
database_cross_reference: SNOMEDCT_US_2016_03_01:266225001
database_cross_reference: SNOMEDCT_US_2016_03_01:276203008
database_cross_reference: SNOMEDCT_US_2016_03_01:9399000
database_cross_reference: UMLS_CUI:C0040558
has_obo_namespace: disease_ontology
has_exact_synonym: disseminated toxoplasmosis
definition: A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

substance dependence
type: Class
subclass of: disease of mental health
definition: A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance.
id: DOID:9973
database_cross_reference: NCI:C35458
database_cross_reference: SNOMEDCT_US_2016_03_01:103326000
database_cross_reference: SNOMEDCT_US_2016_03_01:255338002
database_cross_reference: UMLS_CUI:C0439857
has_obo_namespace: disease_ontology

Axiom
annotated target: A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Drug_dependence
annotated source: substance dependence
annotated property: definition

drug dependence
type: Class
subclass of: substance dependence
definition: A substance dependence that involves the continued use of drugs despite problems related to use of the substance.
id: DOID:9974
database_cross_reference: ICD9CM:304.6
database_cross_reference: ICD9CM:304.60
database_cross_reference: SNOMEDCT_US_2016_03_01:191859004
database_cross_reference: SNOMEDCT_US_2016_03_01:191860009
database_cross_reference: SNOMEDCT_US_2016_03_01:191864000
database_cross_reference: SNOMEDCT_US_2016_03_01:268644006
database_cross_reference: UMLS_CUI:C0029792
has_obo_namespace: disease_ontology

Axiom
annotated target: A substance dependence that involves the continued use of drugs despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Drug_dependence
annotated source: drug dependence
annotated property: definition

cocaine dependence
type: Class
subclass of: drug dependence
definition: A drug dependence that is a psychological dependency on the regular use of cocaine.
id: DOID:9975
database_cross_reference: ICD10CM:F14.2
database_cross_reference: ICD9CM:304.2
database_cross_reference: ICD9CM:304.20
database_cross_reference: MSH:D019970
database_cross_reference: NCI:C34492
database_cross_reference: SNOMEDCT_US_2016_03_01:191829009
database_cross_reference: SNOMEDCT_US_2016_03_01:191830004
database_cross_reference: SNOMEDCT_US_2016_03_01:191834008
database_cross_reference: SNOMEDCT_US_2016_03_01:192254002
database_cross_reference: SNOMEDCT_US_2016_03_01:286934009
database_cross_reference: SNOMEDCT_US_2016_03_01:31956009
database_cross_reference: UMLS_CUI:C0600427
has_obo_namespace: disease_ontology

Axiom
annotated target: A drug dependence that is a psychological dependency on the regular use of cocaine.
database_cross_reference: url:http://en.wikipedia.org/wiki/Cocaine_dependence
annotated source: cocaine dependence
annotated property: definition

heroin dependence
type: Class
subclass of: opiate dependence
definition: An opiate dependence that involves the continued use of heroin despite problems related to use of the substance.
id: DOID:9976
database_cross_reference: MSH:D006556
database_cross_reference: NCI:C34694
database_cross_reference: SNOMEDCT_US_2016_03_01:191817000
database_cross_reference: SNOMEDCT_US_2016_03_01:192220003
database_cross_reference: SNOMEDCT_US_2016_03_01:231477003
database_cross_reference: UMLS_CUI:C0019337
has_obo_namespace: disease_ontology

Axiom
annotated target: An opiate dependence that involves the continued use of heroin despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Opioid_dependence
annotated source: heroin dependence
annotated property: definition

hallucinogen dependence
type: Class
subclass of: drug dependence
definition: A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance.
id: DOID:9977
database_cross_reference: ICD10CM:F16.2
database_cross_reference: ICD9CM:304.5
database_cross_reference: ICD9CM:304.50
database_cross_reference: NCI:C34657
database_cross_reference: SNOMEDCT_US_2016_03_01:191847003
database_cross_reference: SNOMEDCT_US_2016_03_01:191848008
database_cross_reference: SNOMEDCT_US_2016_03_01:191852008
database_cross_reference: SNOMEDCT_US_2016_03_01:268643000
database_cross_reference: SNOMEDCT_US_2016_03_01:38247002
database_cross_reference: UMLS_CUI:C0018528
has_obo_namespace: disease_ontology

Axiom
annotated target: A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance.
database_cross_reference: url:http://en.wikipedia.org/wiki/Hallucinogenic_drugs
annotated source: hallucinogen dependence
annotated property: definition

hypoglycemia
type: Class
subclass of: disease of metabolism
id: DOID:9993
has_exact_synonym: Hypoglycaemia
database_cross_reference: ICD10CM:E16.2
database_cross_reference: ICD9CM:251.2
database_cross_reference: MSH:D007003
database_cross_reference: NCI:C3126
database_cross_reference: SNOMEDCT_US_2015_03_01:154691006
database_cross_reference: SNOMEDCT_US_2015_03_01:154693009
database_cross_reference: SNOMEDCT_US_2015_03_01:190433001
database_cross_reference: SNOMEDCT_US_2015_03_01:190436009
database_cross_reference: SNOMEDCT_US_2015_03_01:237630007
database_cross_reference: SNOMEDCT_US_2015_03_01:271327008
database_cross_reference: SNOMEDCT_US_2015_03_01:302866003
database_cross_reference: SNOMEDCT_US_2015_03_01:66694000
database_cross_reference: UMLS_CUI:C0020615
has_obo_namespace: disease_ontology
imported from: doid.owl

Coronavirus infectious disease
type: Class
subclass of: viral infectious disease
definition: A viral infectious disease that has_material_basis_in Coronavirus.
has_obo_namespace: disease_ontology
id: DOID:0080599

Axiom
annotated source: Coronavirus infectious disease
annotated property: definition
annotated target: A viral infectious disease that has_material_basis_in Coronavirus.
database_cross_reference: url:https://www.cdc.gov/coronavirus/
database_cross_reference: url:https://www.ncbi.nlm.nih.gov/books/NBK7782/
database_cross_reference: url:https://www.who.int/health-topics/coronavirus

COVID-19
type: Class
subclass of: Coronavirus infectious disease
definition: A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2.
has_exact_synonym: 2019 Novel Coronavirus (2019-nCoV)
has_exact_synonym: 2019-nCoV infection
has_exact_synonym: COVID19
has_exact_synonym: SARS-CoV-2 infection
has_exact_synonym: Wuhan coronavirus infection
has_exact_synonym: Wuhan seafood market pneumonia virus infection
has_obo_namespace: disease_ontology
id: DOID:0080600

Axiom
annotated source: COVID-19
annotated property: definition
annotated target: A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2.
database_cross_reference: url:https://www.cdc.gov/coronavirus/2019-ncov/about/index.html
database_cross_reference: url:https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=2697049
database_cross_reference: url:https://www.ncbi.nlm.nih.gov/pubmed/?term=32007143
database_cross_reference: url:https://www.ncbi.nlm.nih.gov/pubmed/?term=32007145
database_cross_reference: url:https://www.who.int/emergencies/diseases/novel-coronavirus-2019

Middle East respiratory syndrome
type: Class
subclass of: Coronavirus infectious disease
definition: A Coronavirus infection that is characterized by severe respiratory illness, including fever, cough, and shortness of breath and that has_material_basis_in MERS-CoV.
has_obo_namespace: disease_ontology
id: DOID:0080642

Axiom
annotated source: Middle East respiratory syndrome
annotated property: definition
annotated target: A Coronavirus infection that is characterized by severe respiratory illness, including fever, cough, and shortness of breath and that has_material_basis_in MERS-CoV.
database_cross_reference: url:https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome
database_cross_reference: url:https://pubmed.ncbi.nlm.nih.gov/23891402/
database_cross_reference: url:https://pubmed.ncbi.nlm.nih.gov/29495250
database_cross_reference: url:https://www.cdc.gov/coronavirus/mers/index.html
database_cross_reference: url:https://www.who.int/news-room/q-a-detail/middle-east-respiratory-syndrome-coronavirus-(mers-cov)