format-version: 1.2 data-version: releases/2024-01-31 subsetdef: 1_STAR "" subsetdef: 2_STAR "" subsetdef: 3_STAR "" subsetdef: abnormal_slim "" subsetdef: absent_slim "" subsetdef: attribute_slim "" subsetdef: cell_quality "" subsetdef: common_anatomy "" subsetdef: disposition_slim "" subsetdef: efo_slim "" subsetdef: gocheck_do_not_annotate "" subsetdef: gocheck_do_not_manually_annotate "" subsetdef: goslim_agr "" subsetdef: goslim_candida "" subsetdef: goslim_chembl "" subsetdef: goslim_drosophila "" subsetdef: goslim_flybase_ribbon "" subsetdef: goslim_generic "" subsetdef: goslim_metagenomics "" subsetdef: goslim_mouse "" subsetdef: goslim_pir "" subsetdef: goslim_plant "" subsetdef: goslim_pombe "" subsetdef: goslim_prokaryote "" subsetdef: goslim_yeast "" subsetdef: hpo_slim "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology "" subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam "" subsetdef: mpath_slim "" subsetdef: prokaryote_subset "" subsetdef: relational_slim "" subsetdef: ro-eco "" subsetdef: RO:0002259 "" subsetdef: scalar_slim "" subsetdef: term_scheduled_for_obsoletion "" subsetdef: ubprop:upper_level "" subsetdef: upper_level "" subsetdef: value_slim "" synonymtypedef: blast_name "" synonymtypedef: BRAND_NAME "" synonymtypedef: common_name "" synonymtypedef: genbank_common_name "" synonymtypedef: INN "" synonymtypedef: IUPAC_NAME "" synonymtypedef: synonym "" ontology: phipo property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-07-09T13:43:00Z" xsd:string property_value: dc-description "Ontology of species-neutral phenotypes observed in pathogen-host interactions." xsd:string property_value: dc-title "Pathogen Host Interactions Phenotype Ontology" xsd:string property_value: dcterms-license "https://creativecommons.org/licenses/by/3.0/" xsd:string property_value: owl:versionInfo "2024-01-31" xsd:string [Term] id: BFO:0000001 name: entity property_value: BFO:0000179 "entity" xsd:string property_value: BFO:0000180 "Entity" xsd:string property_value: IAO:0000112 "Julius Caesar" xsd:string property_value: IAO:0000112 "the Second World War" xsd:string property_value: IAO:0000112 "Verdi’s Requiem" xsd:string property_value: IAO:0000112 "your body mass index" xsd:string property_value: IAO:0000116 "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string property_value: IAO:0000116 "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000004", comment="per discussion with Barry Smith", http://www.w3.org/2000/01/rdf-schema#seeAlso="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"} property_value: IAO:0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/001-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] is_a: BFO:0000001 ! entity disjoint_from: BFO:0000003 ! occurrent relationship: part_of BFO:0000002 {all_only="true"} ! continuant property_value: BFO:0000179 "continuant" xsd:string property_value: BFO:0000180 "Continuant" xsd:string property_value: IAO:0000116 "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string property_value: IAO:0000116 "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000007"} property_value: IAO:0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000601 "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000601 "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} property_value: IAO:0000602 "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} property_value: IAO:0000602 "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] is_a: BFO:0000001 ! entity relationship: part_of BFO:0000003 {all_only="true"} ! occurrent property_value: BFO:0000179 "occurrent" xsd:string property_value: BFO:0000180 "Occurrent" xsd:string property_value: IAO:0000116 "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string property_value: IAO:0000116 "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string property_value: IAO:0000116 "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000006", comment="per discussion with Barry Smith"} property_value: IAO:0000116 "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000012"} property_value: IAO:0000600 "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/077-002"} property_value: IAO:0000601 "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"} property_value: IAO:0000601 "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"} property_value: IAO:0000602 "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"} property_value: IAO:0000602 "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000004 {all_only="true"} ! independent continuant property_value: BFO:0000179 "ic" xsd:string property_value: BFO:0000180 "IndependentContinuant" xsd:string property_value: IAO:0000112 "a chair" xsd:string property_value: IAO:0000112 "a heart" xsd:string property_value: IAO:0000112 "a leg" xsd:string property_value: IAO:0000112 "a molecule" xsd:string property_value: IAO:0000112 "a spatial region" xsd:string property_value: IAO:0000112 "an atom" xsd:string property_value: IAO:0000112 "an orchestra." xsd:string property_value: IAO:0000112 "an organism" xsd:string property_value: IAO:0000112 "the bottom right portion of a human torso" xsd:string property_value: IAO:0000112 "the interior of your mouth" xsd:string property_value: IAO:0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000601 "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} property_value: IAO:0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} property_value: IAO:0000602 "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"} comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. is_a: BFO:0000003 ! occurrent property_value: BFO:0000179 "process" xsd:string property_value: BFO:0000180 "Process" xsd:string property_value: IAO:0000112 "a process of cell-division, \\ a beating of the heart" xsd:string property_value: IAO:0000112 "a process of meiosis" xsd:string property_value: IAO:0000112 "a process of sleeping" xsd:string property_value: IAO:0000112 "the course of a disease" xsd:string property_value: IAO:0000112 "the flight of a bird" xsd:string property_value: IAO:0000112 "the life of an organism" xsd:string property_value: IAO:0000112 "your process of aging." xsd:string property_value: IAO:0000116 "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string property_value: IAO:0000602 "(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000016 name: disposition is_a: BFO:0000017 ! realizable entity disjoint_from: BFO:0000023 ! role property_value: BFO:0000179 "disposition" xsd:string property_value: BFO:0000180 "Disposition" xsd:string property_value: IAO:0000112 "an atom of element X has the disposition to decay to an atom of element Y" xsd:string property_value: IAO:0000112 "certain people have a predisposition to colon cancer" xsd:string property_value: IAO:0000112 "children are innately disposed to categorize objects in certain ways." xsd:string property_value: IAO:0000112 "the cell wall is disposed to filter chemicals in endocytosis and exocytosis" xsd:string property_value: IAO:0000116 "BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type." xsd:string property_value: IAO:0000600 "b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"} property_value: IAO:0000601 "If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"} property_value: IAO:0000602 "(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"} property_value: IAO:0000602 "(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000017 name: realizable entity def: "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." [] is_a: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000019 ! quality relationship: part_of BFO:0000017 {all_only="true"} ! realizable entity property_value: BFO:0000179 "realizable" xsd:string property_value: BFO:0000180 "RealizableEntity" xsd:string property_value: IAO:0000112 "the disposition of this piece of metal to conduct electricity." xsd:string property_value: IAO:0000112 "the disposition of your blood to coagulate" xsd:string property_value: IAO:0000112 "the function of your reproductive organs" xsd:string property_value: IAO:0000112 "the role of being a doctor" xsd:string property_value: IAO:0000112 "the role of this boundary to delineate where Utah and Colorado meet" xsd:string property_value: IAO:0000600 "To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"} property_value: IAO:0000601 "All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"} property_value: IAO:0000602 "(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"} property_value: IAO:0000602 "(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000019 {all_only="true"} ! quality [Term] id: BFO:0000020 name: specifically dependent continuant def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." [] def: "b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/131-004"} def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"} comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000020 {all_only="true"} ! specifically dependent continuant property_value: BFO:0000179 "sdc" xsd:string property_value: BFO:0000180 "SpecificallyDependentContinuant" xsd:string property_value: IAO:0000112 "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string property_value: IAO:0000112 "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string property_value: IAO:0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string property_value: IAO:0000112 "the disposition of this fish to decay" xsd:string property_value: IAO:0000112 "the function of this heart: to pump blood" xsd:string property_value: IAO:0000112 "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string property_value: IAO:0000112 "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string property_value: IAO:0000112 "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string property_value: IAO:0000112 "the role of being a doctor" xsd:string property_value: IAO:0000112 "the shape of this hole." xsd:string property_value: IAO:0000112 "the smell of this portion of mozzarella" xsd:string property_value: IAO:0000116 "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000005", comment="per discussion with Barry Smith"} property_value: IAO:0000602 "(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/131-004"} property_value: IAO:0000602 "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000023 name: role def: "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." [] is_a: CHEBI:50906 ! role equivalent_to: CHEBI:50906 ! role [Term] id: BFO:0000031 name: generically dependent continuant def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." [] def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"} is_a: BFO:0000002 ! continuant property_value: BFO:0000179 "gdc" xsd:string property_value: BFO:0000180 "GenericallyDependentContinuant" xsd:string property_value: IAO:0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity." xsd:string property_value: IAO:0000112 "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop" xsd:string property_value: IAO:0000112 "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule." xsd:string property_value: IAO:0000602 "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000034 name: function is_a: BFO:0000016 ! disposition [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant property_value: BFO:0000179 "material" xsd:string property_value: BFO:0000180 "MaterialEntity" xsd:string property_value: IAO:0000112 "a flame" xsd:string property_value: IAO:0000112 "a forest fire" xsd:string property_value: IAO:0000112 "a human being" xsd:string property_value: IAO:0000112 "a hurricane" xsd:string property_value: IAO:0000112 "a photon" xsd:string property_value: IAO:0000112 "a puff of smoke" xsd:string property_value: IAO:0000112 "a sea wave" xsd:string property_value: IAO:0000112 "a tornado" xsd:string property_value: IAO:0000112 "an aggregate of human beings." xsd:string property_value: IAO:0000112 "an energy wave" xsd:string property_value: IAO:0000112 "an epidemic" xsd:string property_value: IAO:0000112 "the undetached arm of a human being" xsd:string property_value: IAO:0000116 "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string property_value: IAO:0000116 "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string property_value: IAO:0000116 "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string property_value: IAO:0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} property_value: IAO:0000601 "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} property_value: IAO:0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} property_value: IAO:0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: CARO:0000000 name: anatomical entity def: "A part of a multicellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a multicellular organism with granularity above the level of a protein complex." [] is_a: BFO:0000040 ! material entity disjoint_from: IDO:0000528 ! pathogen property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CHEBI:100147 name: nalidixic acid namespace: chebi_ontology alt_id: CHEBI:7456 def: "A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species." [] subset: 3_STAR synonym: "1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid" RELATED [ChemIDplus] synonym: "1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure" RELATED [ChemIDplus] synonym: "1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid" RELATED [ChemIDplus] synonym: "1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid" RELATED [ChemIDplus] synonym: "1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid" RELATED [ChEMBL] synonym: "3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one" RELATED [ChemIDplus] synonym: "acide nalidixique" RELATED INN [ChemIDplus] synonym: "acido nalidixico" RELATED INN [ChemIDplus] synonym: "acidum nalidixicum" RELATED INN [ChemIDplus] synonym: "NALIDIXIC ACID" EXACT [ChEMBL] synonym: "Nalidixic acid" EXACT [KEGG_COMPOUND] synonym: "nalidixic acid" RELATED INN [ChemIDplus] xref: CAS:389-08-2 {source="ChemIDplus"} xref: CAS:389-08-2 {source="KEGG COMPOUND"} xref: Drug_Central:1875 {source="DrugCentral"} xref: DrugBank:DB00779 xref: KEGG:C05079 xref: KEGG:D00183 xref: LINCS:LSM-5590 xref: Patent:BE612258 xref: Patent:US3590036 xref: PDBeChem:NIX xref: PMID:11321869 {source="Europe PMC"} xref: PMID:12002106 {source="Europe PMC"} xref: PMID:12399485 {source="Europe PMC"} xref: PMID:12702698 {source="Europe PMC"} xref: PMID:14107587 {source="Europe PMC"} xref: PMID:16107187 {source="Europe PMC"} xref: PMID:16423473 {source="Europe PMC"} xref: PMID:16667857 {source="Europe PMC"} xref: PMID:16803589 {source="Europe PMC"} xref: PMID:17132068 {source="Europe PMC"} xref: PMID:17631104 {source="Europe PMC"} xref: PMID:18788798 {source="Europe PMC"} xref: PMID:19071706 {source="Europe PMC"} xref: PMID:28166217 {source="Europe PMC"} xref: Reaxys:750515 {source="Reaxys"} xref: VSDB:1880 xref: Wikipedia:Nalidixic_Acid is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:73537 ! 1,8-naphthyridine derivative is_a: CHEBI:86324 ! quinolone antibiotic relationship: is_conjugate_acid_of CHEBI:62070 ! nalidixic acid anion relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H12N2O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MHWLWQUZZRMNGJ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "232.23530" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "232.08479" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCn1cc(C(O)=O)c(=O)c2ccc(C)nc12" xsd:string [Term] id: CHEBI:10022 name: deoxynivalenol namespace: chebi_ontology def: "A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination." [] subset: 3_STAR synonym: "3alpha,7alpha,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one" EXACT IUPAC_NAME [IUPAC] synonym: "3alpha,7alpha,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one" RELATED [ChemIDplus] synonym: "4-Deoxynivalenol" RELATED [ChemIDplus] synonym: "4-Desoxynivalenol" RELATED [ChemIDplus] synonym: "Dehydronivalenol" RELATED [ChemIDplus] synonym: "Desoxynivalenol" RELATED [ChemIDplus] synonym: "DON" RELATED [KEGG_COMPOUND] synonym: "Vomitoxin" RELATED [KEGG_COMPOUND] xref: CAS:51481-10-8 {source="ChemIDplus"} xref: CAS:51481-10-8 {source="KEGG COMPOUND"} xref: Chemspider:36584 xref: KEGG:C09747 xref: KNApSAcK:C00003201 xref: LIPID_MAPS_instance:LMPR0103180002 {source="LIPID MAPS"} xref: PMID:28780485 {source="Europe PMC"} xref: PMID:30284112 {source="Europe PMC"} xref: PMID:30714884 {source="Europe PMC"} xref: PMID:30760085 {source="Europe PMC"} xref: PMID:30802751 {source="Europe PMC"} xref: PMID:30806951 {source="Europe PMC"} xref: PMID:30841652 {source="Europe PMC"} xref: PMID:31394401 {source="Europe PMC"} xref: PMID:31817218 {source="Europe PMC"} xref: PMID:31867960 {source="Europe PMC"} xref: PMID:31960350 {source="Europe PMC"} xref: PMID:32218143 {source="Europe PMC"} xref: PMID:32260237 {source="Europe PMC"} xref: PMID:32560237 {source="Europe PMC"} xref: PMID:32745571 {source="Europe PMC"} xref: PMID:32805342 {source="Europe PMC"} xref: PMID:32851525 {source="Europe PMC"} xref: PMID:32880717 {source="Europe PMC"} xref: PMID:32930227 {source="Europe PMC"} xref: Wikipedia:Vomitoxin is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:2468 ! secondary alpha-hydroxy ketone is_a: CHEBI:27136 ! triol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:51689 ! enone is_a: CHEBI:55517 ! trichothecene property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H20O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LINOMUASTDIRTM-QGRHZQQGSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "296.319" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "296.12599" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12O[C@]3([H])C=C(C)C(=O)[C@@H](O)[C@]3(CO)[C@@](C)(C[C@H]1O)[C@]21CO1" xsd:string [Term] id: CHEBI:10023 name: voriconazole namespace: chebi_ontology alt_id: CHEBI:127308 def: "A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4." [] subset: 3_STAR synonym: "(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol" EXACT IUPAC_NAME [IUPAC] synonym: "(alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol" RELATED [ChemIDplus] synonym: "(R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol" RELATED [ChEBI] synonym: "VCZ" RELATED [DrugBank] synonym: "Vfend" RELATED BRAND_NAME [ChEBI] synonym: "voriconazol" RELATED INN [WHO_MedNet] synonym: "voriconazole" EXACT [UniProt] synonym: "voriconazole" RELATED INN [WHO_MedNet] synonym: "voriconazole" RELATED INN [ChemIDplus] synonym: "voriconazolum" RELATED INN [WHO_MedNet] xref: Beilstein:7694998 {source="Beilstein"} xref: CAS:137234-62-9 {source="KEGG DRUG"} xref: CAS:137234-62-9 {source="ChemIDplus"} xref: CAS:137234-62-9 {source="KEGG COMPOUND"} xref: CAS:137234-62-9 {source="DrugBank"} xref: Drug_Central:2846 {source="DrugCentral"} xref: DrugBank:DB00582 xref: KEGG:C07622 xref: KEGG:D00578 xref: LINCS:LSM-5244 xref: Patent:EP440372 xref: Patent:US5278175 xref: PMID:12940129 {source="Europe PMC"} xref: PMID:22718362 {source="Europe PMC"} xref: PMID:23392902 {source="Europe PMC"} xref: PMID:23527908 {source="Europe PMC"} xref: PMID:23766489 {source="Europe PMC"} xref: PMID:24102553 {source="Europe PMC"} xref: Wikipedia:Voriconazole is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:38582 ! difluorobenzene is_a: CHEBI:39447 ! pyrimidines is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H14F3N5O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BCEHBSKCWLPMDN-MGPLVRAMSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "349.31050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "349.11504" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F" xsd:string [Term] id: CHEBI:100241 name: ciprofloxacin namespace: chebi_ontology alt_id: CHEBI:102718 alt_id: CHEBI:3717 alt_id: CHEBI:41638 def: "A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively." [] subset: 3_STAR synonym: "1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID" RELATED [PDBeChem] synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid" RELATED [ChEMBL] synonym: "Ciprofloxacin" EXACT [KEGG_COMPOUND] synonym: "ciprofloxacin" EXACT [ChEMBL] synonym: "ciprofloxacin" RELATED INN [ChemIDplus] synonym: "ciprofloxacine" RELATED INN [ChemIDplus] synonym: "ciprofloxacino" RELATED INN [ChemIDplus] synonym: "ciprofloxacinum" RELATED INN [ChemIDplus] xref: Beilstein:3568352 {source="Beilstein"} xref: CAS:85721-33-1 {source="ChemIDplus"} xref: CAS:85721-33-1 {source="KEGG COMPOUND"} xref: Drug_Central:659 {source="DrugCentral"} xref: DrugBank:DB00537 xref: HMDB:HMDB0014677 xref: KEGG:C05349 xref: KEGG:D00186 xref: LINCS:LSM-5226 xref: Patent:DE3142854 xref: Patent:US4670444 xref: PDBeChem:CPF xref: PMID:10397494 {source="ChEMBL"} xref: PMID:10737746 {source="ChEMBL"} xref: Reaxys:3568352 {source="Reaxys"} xref: VSDB:1763 xref: Wikipedia:Ciprofloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:36709 ! aminoquinoline is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:51454 ! cyclopropanes is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_conjugate_base_of CHEBI:192486 ! ciprofloxacin(1+) relationship: is_tautomer_of CHEBI:192484 ! ciprofloxacin zwitterion relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H18FN3O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYSWGUAQZAJSOK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "331.34150" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "331.13322" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O" xsd:string [Term] id: CHEBI:100246 name: norfloxacin namespace: chebi_ontology alt_id: CHEBI:7629 def: "A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase." [] subset: 3_STAR synonym: "1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure" RELATED [ChemIDplus] synonym: "1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "NFLX" RELATED [KEGG_DRUG] synonym: "norfloxacin" RELATED INN [KEGG_DRUG] synonym: "norfloxacine" RELATED INN [ChemIDplus] synonym: "norfloxacino" RELATED INN [ChemIDplus] synonym: "norfloxacinum" RELATED INN [ChemIDplus] xref: Beilstein:567897 {source="Beilstein"} xref: CAS:70458-96-7 {source="ChemIDplus"} xref: CAS:70458-96-7 {source="KEGG COMPOUND"} xref: Drug_Central:1967 {source="DrugCentral"} xref: DrugBank:DB01059 xref: Gmelin:1576626 {source="Gmelin"} xref: HMDB:HMDB0015192 xref: KEGG:C06687 xref: KEGG:D00210 xref: LINCS:LSM-5286 xref: Patent:BE863429 xref: Patent:DE2840910 xref: Patent:US4146719 xref: Patent:US4292317 xref: PMID:3317294 {source="Europe PMC"} xref: PMID:3908074 {source="Europe PMC"} xref: PMID:6211142 {source="Europe PMC"} xref: PMID:6224685 {source="Europe PMC"} xref: PMID:6234465 {source="Europe PMC"} xref: PMID:6454381 {source="Europe PMC"} xref: PMID:6461606 {source="Europe PMC"} xref: Reaxys:567897 {source="Reaxys"} xref: VSDB:1831 xref: Wikipedia:Norfloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H18FN3O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OGJPXUAPXNRGGI-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "319.33080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "319.13322" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N1CCNCC1" xsd:string [Term] id: CHEBI:102484 name: sulfisoxazole namespace: chebi_ontology alt_id: CHEBI:9343 def: "A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms." [] subset: 3_STAR synonym: "3,4-Dimethyl-5-sulfanilamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethyl-5-sulfonamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethyl-5-sulphanilamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethyl-5-sulphonamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethylisoxazole-5-sulfanilamide" RELATED [ChemIDplus] synonym: "3,4-Dimethylisoxazole-5-sulphanilamide" RELATED [ChemIDplus] synonym: "4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide" RELATED [NIST_Chemistry_WebBook] synonym: "4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide" RELATED [ChemIDplus] synonym: "4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide" EXACT IUPAC_NAME [IUPAC] synonym: "5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-Sulfanilamido-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-Sulphanilamido-3,4-dimethyl-isoxazole" RELATED [ChemIDplus] synonym: "N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide" RELATED [ChemIDplus] synonym: "N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide" RELATED [ChemIDplus] synonym: "N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide" RELATED [ChemIDplus] synonym: "Sulfadimethylisoxazole" RELATED [DrugBank] synonym: "Sulfafurazol" RELATED [DrugBank] synonym: "sulfafurazole" RELATED INN [KEGG_DRUG] synonym: "sulfafurazolum" RELATED INN [ChemIDplus] synonym: "Sulfaisoxazole" RELATED [DrugBank] synonym: "Sulfasoxazole" RELATED [DrugBank] synonym: "Sulfisonazole" RELATED [DrugBank] synonym: "Sulfisoxasole" RELATED [DrugBank] synonym: "Sulfisoxazol" RELATED [DrugBank] synonym: "Sulfofurazole" RELATED [DrugBank] synonym: "Sulphadimethylisoxazole" RELATED [NIST_Chemistry_WebBook] synonym: "Sulphafurazol" RELATED [DrugBank] synonym: "Sulphafurazole" RELATED [DrugBank] synonym: "Sulphaisoxazole" RELATED [DrugBank] synonym: "Sulphisoxazol" RELATED [DrugBank] synonym: "Sulphofurazole" RELATED [DrugBank] xref: Beilstein:263871 {source="Beilstein"} xref: CAS:127-69-5 {source="ChemIDplus"} xref: CAS:127-69-5 {source="NIST Chemistry WebBook"} xref: Drug_Central:2529 {source="DrugCentral"} xref: DrugBank:DB00263 xref: Gmelin:864477 {source="Gmelin"} xref: KEGG:C07318 xref: KEGG:D00450 xref: LINCS:LSM-3120 xref: Patent:US2430094 xref: PMID:1861917 {source="Europe PMC"} xref: PMID:4960234 {source="Europe PMC"} xref: PMID:7356572 {source="Europe PMC"} xref: Wikipedia:Sulfisoxazole is_a: CHEBI:55373 ! isoxazoles is_a: CHEBI:87228 ! sulfonamide antibiotic relationship: has_functional_parent CHEBI:45373 ! sulfanilamide relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C11H13N3O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NHUHCSRWZMLRLA-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "267.30400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "267.06776" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C" xsd:string [Term] id: CHEBI:10545 name: electron namespace: chebi_ontology def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." [] subset: 3_STAR synonym: "beta" RELATED [IUPAC] synonym: "beta(-)" RELATED [ChEBI] synonym: "beta-particle" RELATED [IUPAC] synonym: "e" RELATED [IUPAC] synonym: "e(-)" RELATED [UniProt] synonym: "e-" RELATED [KEGG_COMPOUND] synonym: "electron" EXACT [KEGG_COMPOUND] synonym: "electron" EXACT IUPAC_NAME [IUPAC] synonym: "electron" EXACT [ChEBI] synonym: "Elektron" RELATED [ChEBI] synonym: "negatron" RELATED [IUPAC] xref: KEGG:C05359 xref: PMID:21614077 {source="Europe PMC"} xref: Wikipedia:Electron is_a: CHEBI:36338 ! lepton property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "0.000548579903" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string [Term] id: CHEBI:10642 name: scyllo-inositol namespace: chebi_ontology alt_id: CHEBI:26614 subset: 3_STAR synonym: "(1r,2r,3r,4r,5r,6r)-cyclohexane-1,2,3,4,5,6-hexol" RELATED [IUPAC] synonym: "1,3,5/2,4,6-cyclohexanehexol" RELATED [IUPAC] synonym: "Cocositol" RELATED [NIST_Chemistry_WebBook] synonym: "Quercinitol" RELATED [ChemIDplus] synonym: "Scyllitol" RELATED [ChemIDplus] synonym: "scyllo-Inositol" EXACT [KEGG_COMPOUND] synonym: "scyllo-inositol" EXACT IUPAC_NAME [IUPAC] synonym: "scyllo-inositol" EXACT [UniProt] xref: Beilstein:2206312 {source="Beilstein"} xref: CAS:488-59-5 {source="ChemIDplus"} xref: CAS:488-59-5 {source="NIST Chemistry WebBook"} xref: CAS:488-59-5 {source="KEGG COMPOUND"} xref: Gmelin:561300 {source="Gmelin"} xref: KEGG:C06153 xref: PMID:24352657 {source="Europe PMC"} xref: Reaxys:2206312 {source="Reaxys"} is_a: CHEBI:24848 ! inositol relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3+,4+,5-,6-" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CDAISMWEOUEBRE-CDRYSYESSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:130181 name: calmodulin antagonist namespace: chebi_ontology def: "An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin." [] subset: 3_STAR xref: PMID:26717596 {source="Europe PMC"} is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:131604 name: Mycoplasma genitalium metabolite namespace: chebi_ontology def: "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium." [] subset: 3_STAR synonym: "Mycoplasma genitalium metabolites" RELATED [ChEBI] is_a: CHEBI:76969 ! bacterial metabolite [Term] id: CHEBI:131605 name: dicarboxylic acid monoester(1-) namespace: chebi_ontology def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a dicarboxylic acid monoester." [] subset: 3_STAR is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:36244 ! dicarboxylic acid monoester [Term] id: CHEBI:131609 name: pneumocandin B0 namespace: chebi_ontology def: "An echinocandin initially isolated as a very minor bioactive fermentation product of Glarea lozoyensis (originally known as Zalerion arboricola). Subsequent random mutagenesis work and optimisation of the fermentation medium permitted the industrial production of pneumocandin B0, which is used as the starting point for the synthesis of the antifungal drug caspofungin." [] subset: 3_STAR synonym: "(10R,12S)-N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide" EXACT IUPAC_NAME [IUPAC] synonym: "L 688,786" RELATED [ChemIDplus] synonym: "L-688,786" RELATED [ChemIDplus] synonym: "L-688786" RELATED [ChemIDplus] synonym: "pneumocandin B(0)" RELATED [ChemIDplus] synonym: "pneumocardin B(0)" RELATED [ChemIDplus] xref: CAS:135575-42-7 {source="ChemIDplus"} xref: PMID:24086376 {source="Europe PMC"} xref: PMID:24270605 {source="Europe PMC"} xref: PMID:25527531 {source="Europe PMC"} xref: Reaxys:9316734 {source="Reaxys"} xref: Wikipedia:Pneumocandin_Bo is_a: CHEBI:24613 ! homodetic cyclic peptide is_a: CHEBI:57248 ! echinocandin relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C50H80N8O17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C50H80N8O17/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(66)52-31-22-35(64)46(71)56-48(73)41-33(62)18-19-57(41)50(75)39(34(63)23-36(51)65)54-47(72)40(43(68)42(67)28-14-16-29(60)17-15-28)55-45(70)32-21-30(61)24-58(32)49(74)38(27(4)59)53-44(31)69/h14-17,25-27,30-35,38-43,46,59-64,67-68,71H,5-13,18-24H2,1-4H3,(H2,51,65)(H,52,66)(H,53,69)(H,54,72)(H,55,70)(H,56,73)/t25-,26+,27+,30+,31-,32-,33-,34+,35+,38-,39-,40-,41-,42-,43-,46+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DQXPFAADCTZLNL-FXDJFZINSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1065.216" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1064.56414" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@]12(N(C[C@@H](C1)O)C([C@H]([C@@H](C)O)NC(=O)[C@](C[C@H]([C@@H](O)NC([C@@H]3[C@H](CCN3C([C@H]([C@@H](CC(N)=O)O)NC(=O)[C@H]([C@@H]([C@H](C4=CC=C(C=C4)O)O)O)NC2=O)=O)O)=O)O)(NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)[H])=O)[H]" xsd:string [Term] id: CHEBI:131871 name: hydroxy polyunsaturated fatty acid anion namespace: chebi_ontology def: "Any polyunsaturated fatty acid anion carrying one or more hydroxy substituents." [] subset: 3_STAR synonym: "a hydroxy polyunsaturated fatty acid" RELATED [UniProt] synonym: "hydroxy polyunsaturated fatty acid anions" RELATED [ChEBI] synonym: "hydroxy PUFA" RELATED [SUBMITTER] is_a: CHEBI:59835 ! hydroxy fatty acid anion is_a: CHEBI:76567 ! polyunsaturated fatty acid anion relationship: is_conjugate_base_of CHEBI:140345 ! hydroxy polyunsaturated fatty acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO3R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "61.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.99257" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O*C([O-])=O" xsd:string [Term] id: CHEBI:131927 name: dicarboxylic acids and O-substituted derivatives namespace: chebi_ontology def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." [] subset: 3_STAR synonym: "dicarboxylic acids and derivatives" RELATED [ChEBI] is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:132130 name: hydroxyquinone namespace: chebi_ontology def: "Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group." [] subset: 3_STAR synonym: "hydroxyquinones" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:36141 ! quinone [Term] id: CHEBI:132142 name: 1,4-naphthoquinones namespace: chebi_ontology def: "A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring." [] subset: 3_STAR is_a: CHEBI:25481 ! naphthoquinone is_a: CHEBI:25830 ! p-quinones [Term] id: CHEBI:132155 name: hydroxynaphthoquinone namespace: chebi_ontology def: "Any naphthoquinone in which the naphthaoquinone moiety is substituted by at least one hydroxy group." [] subset: 3_STAR synonym: "hydroxynaphthoquinones" RELATED [ChEBI] xref: Wikipedia:Hydroxynaphthoquinone is_a: CHEBI:132130 ! hydroxyquinone is_a: CHEBI:25481 ! naphthoquinone [Term] id: CHEBI:132157 name: hydroxy-1,4-naphthoquinone namespace: chebi_ontology def: "Any member of the class of 1,4-naphthoquinones in which the naphthoquinone moiety is substituted by at least one hydroxy group." [] subset: 3_STAR synonym: "hydroxy-1,4-naphthoquinones" RELATED [ChEBI] is_a: CHEBI:132142 ! 1,4-naphthoquinones is_a: CHEBI:132155 ! hydroxynaphthoquinone [Term] id: CHEBI:13248 name: anilide namespace: chebi_ontology def: "Any aromatic amide obtained by acylation of aniline." [] subset: 3_STAR synonym: "an anilide" RELATED [UniProt] synonym: "N-phenyl amide" RELATED [ChEBI] synonym: "N-phenyl amides" RELATED [ChEBI] xref: KEGG:C01402 xref: PMID:23535982 {source="Europe PMC"} xref: PMID:23968552 {source="Europe PMC"} xref: PMID:24273122 {source="Europe PMC"} xref: PMID:6205897 {source="Europe PMC"} is_a: CHEBI:22712 ! benzenes is_a: CHEBI:62733 ! aromatic amide relationship: has_functional_parent CHEBI:17296 ! aniline property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6NOR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "120.12860" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04494" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)Nc1ccccc1" xsd:string [Term] id: CHEBI:132717 name: bleaching agent namespace: chebi_ontology def: "A reagent that lightens or whitens a substrate through chemical reaction. Bleaching reactions usually involve oxidative or reductive processes that degrade colour systems. Bleaching can occur by destroying one or more of the double bonds in the conjugated chain, by cleaving the conjugated chain, or by oxidation of one of the other moieties in the conjugated chain. Their reactivity results in many bleaches having strong bactericidal, disinfecting, and sterilising properties." [] subset: 3_STAR xref: Wikipedia:Bleach is_a: CHEBI:33893 ! reagent [Term] id: CHEBI:133011 name: oxytetracycline zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the adjacent tertiary amino group of oxytetracycline; major species at pH 7.3." [] subset: 3_STAR synonym: "(1S,4aS,11S,11aR,12S,12aR)-3-carbamoyl-1-(dimethylazaniumyl)-4a,5,7,11,12-pentahydroxy-11-methyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-2-olate" EXACT IUPAC_NAME [IUPAC] synonym: "oxytetracycline" RELATED [UniProt] xref: MetaCyc:CPD-19255 is_a: CHEBI:144644 ! a tetracycline zwitterion is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:27701 ! oxytetracycline property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H24N2O9" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IWVCMVBTMGNXQD-PXOLEDIWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "460.435" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "460.14818" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@]12([C@](C(=C3C(C=4C(=CC=CC4[C@@]([C@]3([C@@H]1O)[H])(C)O)O)=O)O)(C(C(C(N)=O)=C([C@H]2[NH+](C)C)[O-])=O)O)[H]" xsd:string [Term] id: CHEBI:133135 name: chromenochromene namespace: chebi_ontology def: "Any organic heteroolycyclic compound whose skeleton two ortho-fused chromene rings, and their derivatives." [] subset: 3_STAR synonym: "chromenochromenes" RELATED [ChEBI] is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:133598 name: chlortetracycline(1-) namespace: chebi_ontology def: "An organic anion that is the major structure of chlortetracycline at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "(5S,5aS,6aS,7S,10aS)-9-carbamoyl-4-chloro-7-(dimethylazaniumyl)-5,10a,11-trihydroxy-5-methyl-10,12-dioxo-5,5a,6,6a,7,10,10a,12-octahydrotetracene-1,8-bis(olate)" EXACT IUPAC_NAME [IUPAC] synonym: "7-chlorotetracycline" RELATED [UniProt] xref: MetaCyc:CPD-19258 is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:27644 ! chlortetracycline property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H22ClN2O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/p-1/t7-,8-,15-,21-,22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CYDMQBQPVICBEU-XRNKAMNCSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "477.872" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "477.10702" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC(=C2C(=C1Cl)[C@@]([C@@]3(C(C2=O)=C([C@]4([C@@](C3)([C@@H](C(=C(C4=O)C(N)=O)[O-])[NH+](C)C)[H])O)O)[H])(C)O)[O-]" xsd:string [Term] id: CHEBI:133833 name: benznidazole namespace: chebi_ontology def: "A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease." [] subset: 3_STAR synonym: "2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide" RELATED [ChemIDplus] synonym: "benznidazol" RELATED INN [ChemIDplus] synonym: "benznidazole" RELATED INN [ChemIDplus] synonym: "benznidazole" RELATED INN [KEGG_DRUG] synonym: "benznidazolum" RELATED INN [ChemIDplus] synonym: "N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide" EXACT IUPAC_NAME [IUPAC] synonym: "N-Benzyl-2-nitroimidazol-1-yl-acetamide" RELATED [ChemIDplus] synonym: "N-Benzyl-2-nitroimidazole-1-acetamide" RELATED [ChemIDplus] xref: Beilstein:551486 {source="ChemIDplus"} xref: CAS:22994-85-0 {source="ChemIDplus"} xref: CAS:22994-85-0 {source="KEGG DRUG"} xref: Drug_Central:322 {source="DrugCentral"} xref: KEGG:D02489 xref: PMID:26760092 {source="Europe PMC"} xref: PMID:26760093 {source="Europe PMC"} xref: PMID:26760094 {source="Europe PMC"} xref: PMID:26760095 {source="Europe PMC"} xref: PMID:26974551 {source="Europe PMC"} xref: PMID:26982179 {source="Europe PMC"} xref: PMID:27001816 {source="Europe PMC"} xref: PMID:27067322 {source="Europe PMC"} xref: PMID:27158908 {source="Europe PMC"} xref: PMID:27161638 {source="Europe PMC"} xref: PMID:27223650 {source="Europe PMC"} xref: PMID:27246447 {source="Europe PMC"} xref: PMID:27376278 {source="Europe PMC"} xref: PMID:27487264 {source="Europe PMC"} xref: PMID:27488437 {source="Europe PMC"} xref: PMID:27550362 {source="Europe PMC"} xref: PMID:27619190 {source="Europe PMC"} xref: PMID:27688600 {source="Europe PMC"} xref: Reaxys:551486 {source="Reaxys"} xref: Wikipedia:Benznidazole is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:35716 ! C-nitro compound relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H12N4O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CULUWZNBISUWAS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "260.249" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "260.09094" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C=CC=C1)CNC(CN2C(=NC=C2)[N+]([O-])=O)=O" xsd:string [Term] id: CHEBI:134179 name: volatile organic compound namespace: chebi_ontology def: "Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa." [] subset: 3_STAR synonym: "VOC" RELATED [ChEBI] synonym: "VOCs" RELATED [ChEBI] synonym: "volatile organic compounds" RELATED [ChEBI] xref: Wikipedia:Volatile_organic_compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:135928 name: doripenem namespace: chebi_ontology subset: 2_STAR synonym: "doribax" RELATED [DrugCentral] synonym: "doripenem hydrate" RELATED [DrugCentral] xref: CAS:148016-81-3 {source="DrugCentral"} xref: Drug_Central:4149 {source="DrugCentral"} xref: HMDB:HMDB0041883 is_a: CHEBI:46633 ! carbapenems property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H24N4O6S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AVAACINZEOAHHE-VFZPANTDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "420.507" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "420.11373" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@@H](C3)CNS(N)(=O)=O)=C(N2C1=O)C(O)=O" xsd:string [Term] id: CHEBI:13643 name: glycol namespace: chebi_ontology def: "A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [] subset: 3_STAR synonym: "glycols" EXACT IUPAC_NAME [IUPAC] synonym: "Glykol" RELATED [ChEBI] is_a: CHEBI:23824 ! diol [Term] id: CHEBI:136622 name: aci-nitro compound namespace: chebi_ontology def: "Organonitrogen compounds that have the general structure R(1)(R(2))C=N(O)OH (R(1),R(2) = H, organyl). They are tautomers of C-nitro compounds." [] subset: 3_STAR synonym: "aci-nitro compounds" RELATED [ChEBI] synonym: "oxime N-oxide" RELATED [ChEBI] synonym: "oxime N-oxides" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: has_functional_parent CHEBI:25750 ! oxime relationship: is_tautomer_of CHEBI:35716 ! C-nitro compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNO2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "59.024" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.00073" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(*)(=[N+](O)[O-])*" xsd:string [Term] id: CHEBI:136651 name: S100 calcium-binding protein B inhibitor namespace: chebi_ontology def: "Any inhibitor of S100 calcium-binding protein B." [] subset: 3_STAR synonym: "S100 calcium-binding protein B inhibitors" RELATED [ChEBI] synonym: "S100B inhibitor" RELATED [ChEBI] synonym: "S100B inhibitors" RELATED [ChEBI] xref: Wikipedia:S100B is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:136859 name: pro-agent namespace: chebi_ontology def: "A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent." [] subset: 3_STAR synonym: "pro-agents" RELATED [ChEBI] synonym: "proagent" RELATED [ChEBI] synonym: "proagents" RELATED [ChEBI] xref: PMID:26449612 {source="Europe PMC"} is_a: CHEBI:33232 ! application [Term] id: CHEBI:137419 name: secondary ammonium ion namespace: chebi_ontology def: "An organic cation obtained by protonation of any secondary amino compound; major species at pH 7.3." [] subset: 3_STAR synonym: "a secondary amine" RELATED [UniProt] synonym: "secondary amine(1+)" RELATED [ChEBI] xref: MetaCyc:Secondary-Amines is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:32863 ! secondary amine property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2NR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "16.023" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01872" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*[NH+](*)[H]" xsd:string [Term] id: CHEBI:137598 name: 4-aminosalicylate(1-) namespace: chebi_ontology def: "An aminobenzoate that is the conjugate base of 4-aminosalicylic acid, obtained by deprotonation of the carboxy group. Major miscrospecies at pH 7.3." [] subset: 3_STAR synonym: "4-aminosalicylate" RELATED [UniProt] xref: MetaCyc:CPD-8817 xref: PMID:23118010 {source="SUBMITTER"} xref: Reaxys:3906055 {source="Reaxys"} is_a: CHEBI:22494 ! aminobenzoate is_a: CHEBI:24675 ! hydroxybenzoate relationship: has_functional_parent CHEBI:30762 ! salicylate relationship: is_conjugate_base_of CHEBI:27565 ! 4-aminosalicylic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WUBBRNOQWQTFEX-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "152.128" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "152.03532" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(N)C=C(O)C(C([O-])=O)=C1" xsd:string [Term] id: CHEBI:137982 name: tertiary ammonium ion namespace: chebi_ontology def: "An organic cation obtained by protonation of the amino group of any tertiary amino compound." [] subset: 3_STAR synonym: "a tertiary amine" RELATED [UniProt] synonym: "tertiary amine(1+)" RELATED [ChEBI] synonym: "tertiary ammonium ions" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:50996 ! tertiary amino compound property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HNR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "15.015" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01090" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH+](*)(*)*" xsd:string [Term] id: CHEBI:138015 name: endocrine disruptor namespace: chebi_ontology def: "Any compound that can disrupt the functions of the endocrine (hormone) system" [] subset: 3_STAR synonym: "endocrine disrupting chemical" RELATED [ChEBI] synonym: "endocrine disrupting chemicals" RELATED [ChEBI] synonym: "endocrine disrupting compound" RELATED [ChEBI] synonym: "endocrine disrupting compounds" RELATED [ChEBI] synonym: "endocrine disruptors" RELATED [ChEBI] synonym: "endocrine-disrupting chemical" RELATED [ChEBI] synonym: "endocrine-disrupting chemicals" RELATED [ChEBI] synonym: "hormonally active agent" RELATED [ChEBI] synonym: "hormonally active agents" RELATED [ChEBI] xref: PMID:27929035 {source="Europe PMC"} xref: PMID:28356401 {source="Europe PMC"} xref: PMID:28526231 {source="Europe PMC"} xref: Wikipedia:Endocrine_disruptor is_a: CHEBI:51061 ! hormone receptor modulator [Term] id: CHEBI:138103 name: inorganic acid namespace: chebi_ontology def: "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." [] subset: 3_STAR synonym: "inorganic acids" RELATED [ChEBI] synonym: "mineral acid" RELATED [ChEBI] synonym: "mineral acids" RELATED [ChEBI] xref: Wikipedia:Mineral_acid is_a: CHEBI:39141 ! Bronsted acid [Term] id: CHEBI:138675 name: gas molecular entity namespace: chebi_ontology def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." [] subset: 3_STAR synonym: "gas molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entity" RELATED [ChEBI] xref: Wikipedia:https\://en.wikipedia.org/wiki/Gas is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:138856 name: oxolinic acid namespace: chebi_ontology alt_id: CHEBI:44731 alt_id: CHEBI:7848 def: "A quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the treatment of bacterial infections in cattle, pigs and poultry." [] subset: 3_STAR synonym: "1-Ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-Ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylic acid" RELATED [ChemIDplus] synonym: "5-Ethyl-5,8-dihydro-8-oxo-1,3-dioxolo(4,5-g)quinoline-7-carboxylic acid" RELATED [ChemIDplus] synonym: "5-ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "acide oxolinique" RELATED INN [ChemIDplus] synonym: "acido oxolinico" RELATED INN [WHO_MedNet] synonym: "acidum oxolinicum" RELATED INN [ChemIDplus] synonym: "OA" RELATED [KEGG_DRUG] synonym: "oxolinic acid" RELATED INN [KEGG_DRUG] synonym: "oxolinic acid" RELATED INN [WHO_MedNet] xref: Beilstein:620635 {source="Beilstein"} xref: CAS:14698-29-4 {source="ChemIDplus"} xref: CAS:14698-29-4 {source="KEGG COMPOUND"} xref: Drug_Central:2024 {source="DrugCentral"} xref: Gmelin:2609419 {source="Gmelin"} xref: KEGG:C11342 xref: KEGG:D02301 xref: LINCS:LSM-5811 xref: Patent:US3287458 xref: PDBeChem:OXI xref: PMID:1245092 {source="Europe PMC"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:19596082 {source="Europe PMC"} xref: PMID:20151406 {source="Europe PMC"} xref: PMID:22670590 {source="Europe PMC"} xref: PMID:23353085 {source="Europe PMC"} xref: PMID:23773949 {source="Europe PMC"} xref: PMID:23816421 {source="Europe PMC"} xref: PMID:26678217 {source="Europe PMC"} xref: PMID:26920300 {source="Europe PMC"} xref: PMID:29438107 {source="Europe PMC"} xref: PMID:4616804 {source="Europe PMC"} xref: Reaxys:620635 {source="Reaxys"} xref: VSDB:1879 xref: Wikipedia:Oxolinic_acid is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:86324 ! quinolone antibiotic relationship: is_conjugate_acid_of CHEBI:59066 ! oxolinate relationship: RO:0000087 CHEBI:23924 ! has role enzyme inhibitor relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H11NO5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KYGZCKSPAKDVKC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "261.23010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "261.06372" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCn1cc(C(O)=O)c(=O)c2cc3OCOc3cc12" xsd:string [Term] id: CHEBI:13941 name: carbamate namespace: chebi_ontology subset: 3_STAR synonym: "Carbamat" RELATED [ChEBI] synonym: "carbamate" EXACT [UniProt] synonym: "carbamate" EXACT IUPAC_NAME [IUPAC] synonym: "carbamate ion" RELATED [ChemIDplus] synonym: "carbamic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Karbamat" RELATED [ChEBI] xref: Beilstein:3903503 {source="Beilstein"} xref: CAS:302-11-4 {source="ChemIDplus"} xref: Gmelin:239604 {source="Gmelin"} is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.03212" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.00910" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([O-])=O" xsd:string [Term] id: CHEBI:139492 name: sensitiser namespace: chebi_ontology def: "A chemical compound that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the compound." [] subset: 3_STAR synonym: "sensitisers" RELATED [ChEBI] synonym: "sensitizer" RELATED [ChEBI] synonym: "sensitizers" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:139512 name: EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor namespace: chebi_ontology def: "An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of enoyl-[acyl-carrier-protein] reductase (NADH), EC 1.3.1.9." [] subset: 3_STAR synonym: "acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitor" RELATED [ChEBI] synonym: "acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.9 inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.9 inhibitors" RELATED [ChEBI] synonym: "enoyl-[acyl carrier protein] reductase inhibitor" RELATED [ChEBI] synonym: "enoyl-[acyl carrier protein] reductase inhibitors" RELATED [ChEBI] synonym: "enoyl-ACP reductase inhibitor" RELATED [ChEBI] synonym: "enoyl-ACP reductase inhibitors" RELATED [ChEBI] synonym: "ENR inhibitor" RELATED [ChEBI] synonym: "ENR inhibitors" RELATED [ChEBI] synonym: "NADH-enoyl acyl carrier protein reductase inhibitor" RELATED [ChEBI] synonym: "NADH-enoyl acyl carrier protein reductase inhibitors" RELATED [ChEBI] synonym: "NADH-specific enoyl-ACP reductase inhibitor" RELATED [ChEBI] synonym: "NADH-specific enoyl-ACP reductase inhibitors" RELATED [ChEBI] xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase is_a: CHEBI:76857 ! EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor [Term] id: CHEBI:139588 name: alpha-hydroxy ketone namespace: chebi_ontology def: "An alpha-oxyketone that has a hydroxy group as the alpha-oxy moiety." [] subset: 3_STAR synonym: "alpha-hydroxy ketones" RELATED [ChEBI] synonym: "alpha-hydroxy-ketone" RELATED [ChEBI] synonym: "alpha-hydroxy-ketones" RELATED [ChEBI] synonym: "alpha-hydroxyketone" RELATED [ChEBI] synonym: "alpha-hydroxyketones" RELATED [ChEBI] xref: PMID:15326516 {source="Europe PMC"} xref: PMID:19908854 {source="Europe PMC"} xref: PMID:20382022 {source="Europe PMC"} xref: PMID:23295224 {source="Europe PMC"} is_a: CHEBI:30879 ! alcohol is_a: CHEBI:52396 ! alpha-oxyketone [Term] id: CHEBI:139592 name: tertiary alpha-hydroxy ketone namespace: chebi_ontology def: "An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups." [] subset: 3_STAR synonym: "tertiary alpha-hydroxy ketones" RELATED [ChEBI] synonym: "tertiary alpha-hydroxy-ketone" RELATED [ChEBI] synonym: "tertiary alpha-hydroxy-ketones" RELATED [ChEBI] synonym: "tertiary alpha-hydroxyketone" RELATED [ChEBI] synonym: "tertiary alpha-hydroxyketones" RELATED [ChEBI] is_a: CHEBI:139588 ! alpha-hydroxy ketone is_a: CHEBI:26878 ! tertiary alcohol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2HO2R3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "57.028" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "56.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C(=O)*)(O)(*)*" xsd:string [Term] id: CHEBI:140190 name: calcium-dependent antibiotics namespace: chebi_ontology def: "Any antimicrobial agent whose activity is dependent on the presence of calcium ions." [] subset: 3_STAR synonym: "Ca(2+)-dependent antibiotic" RELATED [ChEBI] synonym: "Ca(2+)-dependent antibiotics" RELATED [ChEBI] synonym: "Ca-dependent antibiotic" RELATED [ChEBI] synonym: "Ca-dependent antibiotics" RELATED [ChEBI] synonym: "calcium-dependent antibiotic" RELATED [ChEBI] xref: PMID:18489906 {source="Europe PMC"} xref: PMID:22711659 {source="Europe PMC"} xref: PMID:29108098 {source="Europe PMC"} xref: PMID:29434326 {source="Europe PMC"} is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:140325 name: secondary carboxamide namespace: chebi_ontology def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1)." [] subset: 3_STAR synonym: "secondary carboxamides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNOR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "43.025" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.00581" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(*)=O)(*)[H]" xsd:string [Term] id: CHEBI:140326 name: tertiary carboxamide namespace: chebi_ontology def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a secondary amine; formula RC(=O)NHR(1)R(2)." [] subset: 3_STAR synonym: "tertiary carboxamides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "42.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(*)=O)(*)*" xsd:string [Term] id: CHEBI:140345 name: hydroxy polyunsaturated fatty acid namespace: chebi_ontology def: "Any polyunsaturated fatty acid carrying one or more hydroxy substituents." [] subset: 3_STAR is_a: CHEBI:24654 ! hydroxy fatty acid is_a: CHEBI:26208 ! polyunsaturated fatty acid relationship: is_conjugate_acid_of CHEBI:131871 ! hydroxy polyunsaturated fatty acid anion [Term] id: CHEBI:140921 name: Hedgehog signaling pathway inhibitor namespace: chebi_ontology def: "Any pathway inhibitor that inhibits the Hedgehog signalling pathway." [] subset: 3_STAR synonym: "Hedgehog pathway inhibitor" RELATED [ChEBI] synonym: "Hedgehog pathway inhibitors" RELATED [ChEBI] synonym: "Hedgehog signaling pathway inhibitors" RELATED [ChEBI] xref: Wikipedia:Hedgehog_pathway_inhibitors is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:140922 name: glioma-associated oncogene inhibitor namespace: chebi_ontology def: "An inhibitor of any of the glioma-associated oncogene (GLI) proteins." [] subset: 3_STAR synonym: "GLI inhibitor" RELATED [ChEBI] synonym: "GLI inhibitors" RELATED [ChEBI] synonym: "glioma-associated oncogene inhibitors" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor [Term] id: CHEBI:141153 name: quinone outside inhibitor namespace: chebi_ontology def: "A mitochondrial cytochrome-bc1 complex inhibitor that acts at the Quinone 'outer' (Qo) binding site of the cytochrome-bc1 complex." [] subset: 3_STAR synonym: "Qo inhibitor" RELATED [ChEBI] synonym: "Qo inhibitors" RELATED [ChEBI] synonym: "QOI" RELATED [ChEBI] synonym: "QOIs" RELATED [ChEBI] synonym: "quinone outside inhibitors" RELATED [ChEBI] xref: Wikipedia:QoI is_a: CHEBI:24127 ! fungicide is_a: CHEBI:38499 ! mitochondrial cytochrome-bc1 complex inhibitor [Term] id: CHEBI:141498 name: hemiaminal ether namespace: chebi_ontology def: "An organic amino compound that is a hemiaminal in which the hydrogen atom of the hydroxy group has been replaced by an organyl group. General formula: R2C(OR')NR2 ( R =/= H ). Also known as alpha-amino ethers." [] subset: 3_STAR synonym: "alpha-amino ether" RELATED [ChEBI] synonym: "alpha-amino ethers" RELATED [ChEBI] synonym: "hemiaminal ethers" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound is_a: CHEBI:50047 ! organic amino compound relationship: has_functional_parent CHEBI:73080 ! hemiaminal property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "42.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(O*)(*)*)(*)*" xsd:string [Term] id: CHEBI:142513 name: oxime anion namespace: chebi_ontology def: "A organic ion resulting from the deprotonation of the hydroxy group of any oxime." [] subset: 3_STAR synonym: "oximate" RELATED [ChEBI] synonym: "oximates" RELATED [ChEBI] synonym: "oxime anion" EXACT [ChEBI] synonym: "oxime anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:25750 ! oxime property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "42.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(*)(=N[O-])*" xsd:string [Term] id: CHEBI:142708 name: tigecycline(1+) namespace: chebi_ontology def: "An ammonium ion that is the conjugate acid of tigecycline; major species at pH 7.3." [] subset: 3_STAR synonym: "(1S,4aS,11aR,12aS)-8-[2-(tert-butylammonio)acetamido]-3-carbamoyl-10-(dimethylamino)-1-(dimethylammonio)-4a,5,7-trihydroxy-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-2-olate" EXACT IUPAC_NAME [IUPAC] synonym: "tigecycline" RELATED [UniProt] xref: MetaCyc:CPD-19260 {source="WebElements"} xref: PMID:16128584 {source="SUBMITTER"} is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:149836 ! tigecycline property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C29H40N5O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/p+1/t12-,14-,21-,29-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FPZLLRFZJZRHSY-HJYUBDRYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "586.658" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "586.28714" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(C(=C([C@H]([C@@]2(C[C@@]3(CC4=C(C=C(C(=C4C(C3=C([C@]12O)O)=O)O)NC(C[NH2+]C(C)(C)C)=O)N(C)C)[H])[H])[NH+](C)C)[O-])C(=O)N)=O" xsd:string [Term] id: CHEBI:144644 name: a tetracycline zwitterion namespace: chebi_ontology subset: 2_STAR synonym: "a tetracycline" RELATED [UniProt] is_a: CHEBI:26895 ! tetracyclines property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H17N2O7R5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "409.370" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "409.10358" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12=C(C=C(C(=C1C(C=3[C@]([C@@H]([C@]4([C@@H](C([O-])=C(C([C@@]4(O)C3O)=O)C(N)=O)[NH+](C)C)[H])*)(C2(*)*)[H])=O)O)*)*" xsd:string [Term] id: CHEBI:145555 name: macropolylide namespace: chebi_ontology def: "Macrolides (macrocyclic lactones) in which the macrocyclic ring contains more than one ester linkage. Macropolylides include macrodiolides, macrotriolides, macrotetrolides and macropentolides, each containing di-, tri-, tetra-, and penta- ester linkages, respectively, in one macrocyclic ring. Macrocyclic lactones containing nitrogen in their skeletons (azamacrolides and macrolide lactams) and also containing oxazole or thiazole in their skeletons are known in nature." [] subset: 3_STAR synonym: "macropolylides" RELATED [ChEBI] is_a: CHEBI:25106 ! macrolide [Term] id: CHEBI:145556 name: macrodiolide namespace: chebi_ontology def: "A macropolylide which contains two ester linkages in one macrocyclic ring." [] subset: 3_STAR synonym: "macrodiolides" RELATED [ChEBI] xref: PMID:17446696 {source="Europe PMC"} xref: PMID:29624065 {source="Europe PMC"} xref: PMID:29671776 {source="Europe PMC"} xref: PMID:31247219 {source="Europe PMC"} is_a: CHEBI:145555 ! macropolylide [Term] id: CHEBI:145565 name: macrolide lactam namespace: chebi_ontology def: "A macrolide in which the macrocyclic lactone ring includes an amide group." [] subset: 3_STAR synonym: "macrolide lactams" RELATED [ChEBI] xref: PMID:11678663 {source="Europe PMC"} xref: PMID:12227772 {source="Europe PMC"} xref: PMID:15248618 {source="Europe PMC"} xref: PMID:17378533 {source="Europe PMC"} xref: PMID:31226284 {source="Europe PMC"} is_a: CHEBI:24995 ! lactam is_a: CHEBI:25106 ! macrolide [Term] id: CHEBI:145790 name: mupirocin(1-) namespace: chebi_ontology def: "A monocarboxylic acid anion that is the conjugate base of mupirocin obtained by the deprotonation of the carboxy group; major microspecies at pH 7.3." [] subset: 3_STAR synonym: "9-({(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-({(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoyl}oxy)nonanoate" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:7025 ! mupirocin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H43O9" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/p-1/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MINDHVHHQZYEEK-HBBNESRFSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "499.622" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "499.29126" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H]1([C@@H]([C@H](CO[C@H]1C\\C(=C\\C(OCCCCCCCCC([O-])=O)=O)\\C)C[C@]2([C@](O2)([H])[C@@H](C)[C@H](C)O)[H])O)O" xsd:string [Term] id: CHEBI:146260 name: spectinomycin(1+) namespace: chebi_ontology def: "A secondary ammonium ion derived from spectinomycin by protonation of the secondary amino group located between the two alcoholic hydroxy groups." [] subset: 3_STAR synonym: "spectinomycin" RELATED [UniProt] is_a: CHEBI:137419 ! secondary ammonium ion relationship: is_conjugate_acid_of CHEBI:9215 ! spectinomycin relationship: is_conjugate_base_of CHEBI:77315 ! spectinomycin(2+) property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H25N2O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/p+1/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UNFWWIHTNXNPBV-WXKVUWSESA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "333.360" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "333.16563" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H]12[C@H](O[C@@]3(O[C@H](C)CC([C@@]3(O1)O)=O)[H])[C@H]([C@H]([NH2+]C)[C@@H]([C@@H]2NC)O)O" xsd:string [Term] id: CHEBI:146295 name: pyranobenzodioxin namespace: chebi_ontology def: "Any organic heterotricyclic compound whose core skeleton consists of a benzodioxin ring that is ortho-fused to a pyran ring." [] subset: 3_STAR synonym: "pyranobenzodioxins" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:149552 name: emetic namespace: chebi_ontology def: "Any agent that induces nausea and vomiting." [] subset: 3_STAR synonym: "emetics" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:149553 name: anticoronaviral agent namespace: chebi_ontology def: "Any antiviral agent which inhibits the activity of coronaviruses." [] subset: 3_STAR synonym: "anti-coronaviral agent" RELATED [ChEBI] synonym: "anti-coronaviral agents" RELATED [ChEBI] synonym: "anti-coronavirus agent" RELATED [ChEBI] synonym: "anti-coronavirus agents" RELATED [ChEBI] synonym: "anticoronaviral agent" EXACT [ChEBI] synonym: "anticoronaviral agents" RELATED [ChEBI] synonym: "anticoronaviral drug" RELATED [ChEBI] synonym: "anticoronaviral drugs" RELATED [ChEBI] synonym: "anticoronavirus agent" RELATED [ChEBI] synonym: "anticoronavirus agents" RELATED [ChEBI] synonym: "anticoronviral agent" RELATED [ChEBI] synonym: "anticoronviral agents" RELATED [ChEBI] xref: Wikipedia:Coronavirus is_a: CHEBI:22587 ! antiviral agent [Term] id: CHEBI:149836 name: tigecycline namespace: chebi_ontology alt_id: CHEBI:29696 alt_id: CHEBI:473970 def: "Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms." [] subset: 3_STAR synonym: "(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide" RELATED [ChemIDplus] synonym: "(4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide" EXACT IUPAC_NAME [IUPAC] xref: CAS:220620-09-7 {source="ChemIDplus"} xref: CAS:220620-09-7 {source="KEGG COMPOUND"} xref: Drug_Central:2661 {source="DrugCentral"} xref: DrugBank:DB00560 xref: KEGG:C12012 xref: KEGG:D01079 xref: PMID:17194827 {source="ChEMBL"} xref: PMID:17210772 {source="ChEMBL"} xref: PMID:17220399 {source="ChEMBL"} xref: PMID:17307973 {source="ChEMBL"} xref: PMID:17353238 {source="ChEMBL"} xref: PMID:17353249 {source="ChEMBL"} xref: Reaxys:8379453 {source="Reaxys"} is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines relationship: is_conjugate_base_of CHEBI:142708 ! tigecycline(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C29H39N5O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FPZLLRFZJZRHSY-HJYUBDRYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "585.64870" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "585.27986" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12Cc3c(cc(NC(=O)CNC(C)(C)C)c(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C" xsd:string [Term] id: CHEBI:15022 name: electron donor namespace: chebi_ontology def: "A molecular entity that can transfer an electron to another molecular entity." [] subset: 3_STAR synonym: "donneur d'electron" RELATED [IUPAC] synonym: "electron donor" EXACT IUPAC_NAME [IUPAC] synonym: "Elektronendonator" RELATED [ChEBI] is_a: CHEBI:17891 ! donor [Term] id: CHEBI:15138 name: sulfide(2-) namespace: chebi_ontology def: "A divalent inorganic anion obtained by removal of both protons from hydrogen sulfide." [] subset: 3_STAR synonym: "S(2-)" RELATED [IUPAC] synonym: "sulfanediide" EXACT IUPAC_NAME [IUPAC] synonym: "Sulfide" RELATED [ChemIDplus] synonym: "sulfide(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "sulphide" RELATED [ChEBI] xref: CAS:18496-25-8 {source="ChemIDplus"} xref: UM-BBD_compID:c0569 {source="UM-BBD"} is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:29919 ! hydrosulfide property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/S/q-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCKMPCXJQFINFW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "32.06600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97317" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S--]" xsd:string [Term] id: CHEBI:15339 name: acceptor namespace: chebi_ontology alt_id: CHEBI:13699 alt_id: CHEBI:2377 def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." [] subset: 3_STAR synonym: "A" RELATED [KEGG_COMPOUND] synonym: "accepteur" RELATED [ChEBI] synonym: "Acceptor" EXACT [KEGG_COMPOUND] synonym: "Akzeptor" RELATED [ChEBI] synonym: "Hydrogen-acceptor" RELATED [KEGG_COMPOUND] synonym: "Oxidized donor" RELATED [KEGG_COMPOUND] xref: KEGG:C00028 xref: KEGG:C16722 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:15354 name: choline namespace: chebi_ontology alt_id: CHEBI:13985 alt_id: CHEBI:23212 alt_id: CHEBI:3665 alt_id: CHEBI:41524 def: "A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function." [] subset: 3_STAR synonym: "2-hydroxy-N,N,N-trimethylethanaminium" EXACT IUPAC_NAME [IUPAC] synonym: "Bilineurine" RELATED [KEGG_COMPOUND] synonym: "Choline" EXACT [KEGG_COMPOUND] synonym: "choline" EXACT [UniProt] synonym: "CHOLINE ION" RELATED [PDBeChem] synonym: "N,N,N-trimethylethanol-ammonium" RELATED [ChEBI] synonym: "N-trimethylethanolamine" RELATED [ChEBI] synonym: "trimethylethanolamine" RELATED [ChEBI] xref: Beilstein:1736748 {source="Beilstein"} xref: CAS:62-49-7 {source="ChemIDplus"} xref: CAS:62-49-7 {source="KEGG COMPOUND"} xref: Drug_Central:3097 {source="DrugCentral"} xref: DrugBank:DB00122 xref: ECMDB:ECMDB00097 xref: Gmelin:324597 {source="Gmelin"} xref: HMDB:HMDB0000097 xref: KEGG:C00114 xref: KEGG:D07690 xref: KNApSAcK:C00007298 xref: MetaCyc:CHOLINE xref: PDBeChem:CHT xref: PMID:10930630 {source="Europe PMC"} xref: PMID:12826235 {source="Europe PMC"} xref: PMID:12946691 {source="Europe PMC"} xref: PMID:14972364 {source="Europe PMC"} xref: PMID:16210714 {source="Europe PMC"} xref: PMID:17087106 {source="Europe PMC"} xref: PMID:17283071 {source="Europe PMC"} xref: PMID:17344490 {source="Europe PMC"} xref: PMID:18204095 {source="Europe PMC"} xref: PMID:18230680 {source="Europe PMC"} xref: PMID:18786517 {source="Europe PMC"} xref: PMID:18786520 {source="Europe PMC"} xref: PMID:19246089 {source="Europe PMC"} xref: PMID:20038853 {source="Europe PMC"} xref: PMID:20446114 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:22961562 {source="Europe PMC"} xref: PMID:23095202 {source="Europe PMC"} xref: PMID:23616508 {source="Europe PMC"} xref: PMID:23637565 {source="Europe PMC"} xref: PMID:23733158 {source="Europe PMC"} xref: PMID:6420466 {source="Europe PMC"} xref: PMID:7590654 {source="Europe PMC"} xref: PMID:9517478 {source="Europe PMC"} xref: Reaxys:1736748 {source="Reaxys"} xref: Wikipedia:Choline xref: YMDB:YMDB00227 is_a: CHEBI:23217 ! cholines relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter relationship: RO:0000087 CHEBI:33284 ! has role nutrient relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H14NO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OEYIOHPDSNJKLS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "104.17080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "104.10699" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[N+](C)(C)CCO" xsd:string [Term] id: CHEBI:15366 name: acetic acid namespace: chebi_ontology alt_id: CHEBI:22169 alt_id: CHEBI:2387 alt_id: CHEBI:40486 def: "A simple monocarboxylic acid containing two carbons." [] subset: 3_STAR synonym: "ACETIC ACID" EXACT [PDBeChem] synonym: "Acetic acid" EXACT [KEGG_COMPOUND] synonym: "acetic acid" EXACT IUPAC_NAME [IUPAC] synonym: "acide acetique" RELATED [ChemIDplus] synonym: "AcOH" RELATED [ChEBI] synonym: "CH3-COOH" RELATED [IUPAC] synonym: "CH3CO2H" RELATED [ChEBI] synonym: "E 260" RELATED [ChEBI] synonym: "E-260" RELATED [ChEBI] synonym: "E260" RELATED [ChEBI] synonym: "Essigsaeure" RELATED [ChEBI] synonym: "Ethanoic acid" RELATED [KEGG_COMPOUND] synonym: "ethoic acid" RELATED [ChEBI] synonym: "Ethylic acid" RELATED [ChemIDplus] synonym: "HOAc" RELATED [ChEBI] synonym: "INS No. 260" RELATED [ChEBI] synonym: "MeCO2H" RELATED [ChEBI] synonym: "MeCOOH" RELATED [ChEBI] synonym: "Methanecarboxylic acid" RELATED [ChemIDplus] xref: Beilstein:506007 {source="Beilstein"} xref: CAS:64-19-7 {source="ChemIDplus"} xref: CAS:64-19-7 {source="NIST Chemistry WebBook"} xref: CAS:64-19-7 {source="KEGG COMPOUND"} xref: Drug_Central:4211 {source="DrugCentral"} xref: Gmelin:1380 {source="Gmelin"} xref: HMDB:HMDB0000042 xref: KEGG:C00033 xref: KEGG:D00010 xref: KNApSAcK:C00001176 xref: LIPID_MAPS_instance:LMFA01010002 {source="LIPID MAPS"} xref: MetaCyc:ACET xref: PDBeChem:ACT xref: PDBeChem:ACY xref: PMID:12005138 {source="Europe PMC"} xref: PMID:15107950 {source="Europe PMC"} xref: PMID:16630552 {source="Europe PMC"} xref: PMID:16774200 {source="Europe PMC"} xref: PMID:17190852 {source="Europe PMC"} xref: PMID:19416101 {source="Europe PMC"} xref: PMID:19469536 {source="Europe PMC"} xref: PMID:22153255 {source="Europe PMC"} xref: PMID:22173419 {source="Europe PMC"} xref: PPDB:1333 xref: Reaxys:506007 {source="Reaxys"} xref: Wikipedia:Acetic_acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:30089 ! acetate relationship: RO:0000087 CHEBI:48356 ! has role protic solvent relationship: RO:0000087 CHEBI:64049 ! has role food acidity regulator relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QTBSBXVTEAMEQO-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.05200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.02113" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(O)=O" xsd:string [Term] id: CHEBI:15369 name: actinomycin namespace: chebi_ontology alt_id: CHEBI:13723 alt_id: CHEBI:22220 alt_id: CHEBI:2445 def: "A large group of antibiotics isolated from various species of Streptomyces and characterised by having a substituted phenoxazine ring linked to two cyclic heterodetic peptides." [] subset: 3_STAR synonym: "Actinomycin" EXACT [KEGG_COMPOUND] synonym: "actinomycins" RELATED [ChEBI] xref: CAS:1402-38-6 {source="KEGG COMPOUND"} xref: CAS:1402-38-6 {source="ChemIDplus"} xref: KEGG:C01775 is_a: CHEBI:23239 ! chromopeptide [Term] id: CHEBI:15693 name: aldose namespace: chebi_ontology alt_id: CHEBI:13755 alt_id: CHEBI:22305 alt_id: CHEBI:2561 def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." [] subset: 3_STAR synonym: "Aldose" EXACT [KEGG_COMPOUND] synonym: "aldoses" RELATED [ChEBI] synonym: "an aldose" RELATED [UniProt] xref: KEGG:C01370 xref: Wikipedia:Aldose is_a: CHEBI:35381 ! monosaccharide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4O2(CH2O)n" xsd:string [Term] id: CHEBI:15705 name: L-alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:13072 alt_id: CHEBI:13243 alt_id: CHEBI:13797 alt_id: CHEBI:21224 alt_id: CHEBI:6175 def: "Any alpha-amino acid having L-configuration at the alpha-carbon." [] subset: 3_STAR synonym: "L-2-Amino acid" RELATED [KEGG_COMPOUND] synonym: "L-alpha-amino acid" EXACT [IUPAC] synonym: "L-alpha-amino acids" EXACT IUPAC_NAME [IUPAC] synonym: "L-alpha-amino acids" RELATED [ChEBI] synonym: "L-Amino acid" RELATED [KEGG_COMPOUND] xref: KEGG:C00151 is_a: CHEBI:33704 ! alpha-amino acid relationship: is_conjugate_acid_of CHEBI:59814 ! L-alpha-amino acid anion relationship: is_tautomer_of CHEBI:59869 ! L-alpha-amino acid zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H]([*])C(O)=O" xsd:string [Term] id: CHEBI:15734 name: primary alcohol namespace: chebi_ontology alt_id: CHEBI:13676 alt_id: CHEBI:14887 alt_id: CHEBI:26262 alt_id: CHEBI:57489 alt_id: CHEBI:8406 def: "A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [] subset: 3_STAR synonym: "1-Alcohol" RELATED [KEGG_COMPOUND] synonym: "a primary alcohol" RELATED [UniProt] synonym: "Primary alcohol" EXACT [KEGG_COMPOUND] synonym: "primary alcohols" RELATED [ChEBI] xref: KEGG:C00226 is_a: CHEBI:30879 ! alcohol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3OR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "31.034" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.01839" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(O)([H])[H]" xsd:string [Term] id: CHEBI:15740 name: formate namespace: chebi_ontology alt_id: CHEBI:14276 alt_id: CHEBI:24081 def: "A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects." [] subset: 3_STAR synonym: "aminate" RELATED [ChEBI] synonym: "formate" EXACT IUPAC_NAME [IUPAC] synonym: "formate" EXACT [UniProt] synonym: "formiate" RELATED [ChEBI] synonym: "formic acid, ion(1-)" RELATED [ChemIDplus] synonym: "formylate" RELATED [ChEBI] synonym: "HCO2 anion" RELATED [NIST_Chemistry_WebBook] synonym: "hydrogen carboxylate" RELATED [ChEBI] synonym: "methanoate" RELATED [ChEBI] xref: Beilstein:1901205 {source="Beilstein"} xref: CAS:71-47-6 {source="ChemIDplus"} xref: CAS:71-47-6 {source="NIST Chemistry WebBook"} xref: Gmelin:1006 {source="Gmelin"} xref: HMDB:HMDB0000142 xref: KEGG:C00058 xref: MetaCyc:FORMATE xref: PMID:17190852 {source="Europe PMC"} xref: PMID:3946945 {source="Europe PMC"} xref: Reaxys:1901205 {source="Reaxys"} xref: UM-BBD_compID:c0106 {source="UM-BBD"} xref: Wikipedia:Formate is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:30751 ! formic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDAGIHXWWSANSR-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01744" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99820" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([O-])=O" xsd:string [Term] id: CHEBI:15841 name: polypeptide namespace: chebi_ontology alt_id: CHEBI:14860 alt_id: CHEBI:8314 def: "A peptide containing ten or more amino acid residues." [] subset: 3_STAR synonym: "polipeptido" RELATED [ChEBI] synonym: "Polypeptid" RELATED [ChEBI] synonym: "Polypeptide" EXACT [KEGG_COMPOUND] synonym: "polypeptides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00403 is_a: CHEBI:16670 ! peptide is_a: CHEBI:33839 ! macromolecule property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H6N2O3R2(C2H2NOR)n" xsd:string [Term] id: CHEBI:15940 name: nicotinic acid namespace: chebi_ontology alt_id: CHEBI:25538 alt_id: CHEBI:44319 alt_id: CHEBI:7559 def: "A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group." [] subset: 3_STAR synonym: "3-carboxylpyridine" RELATED [ChemIDplus] synonym: "3-carboxypyridine" RELATED [NIST_Chemistry_WebBook] synonym: "3-pyridinecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "3-Pyridylcarboxylic acid" RELATED [HMDB] synonym: "acide nicotinique" RELATED INN [WHO_MedNet] synonym: "acido nicotinico" RELATED INN [WHO_MedNet] synonym: "acidum nicotinicum" RELATED INN [WHO_MedNet] synonym: "anti-pellagra vitamin" RELATED [NIST_Chemistry_WebBook] synonym: "beta-pyridinecarboxylic acid" RELATED [ChEBI] synonym: "m-pyridinecarboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Niacin" RELATED [KEGG_COMPOUND] synonym: "Niacor" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Niaspan" RELATED BRAND_NAME [KEGG_DRUG] synonym: "NICOTINIC ACID" EXACT [PDBeChem] synonym: "Nicotinic acid" EXACT [KEGG_COMPOUND] synonym: "nicotinic acid" EXACT IUPAC_NAME [IUPAC] synonym: "nicotinic acid" RELATED INN [WHO_MedNet] synonym: "Nicotinsaure" RELATED [ChemIDplus] synonym: "Nikotinsaeure" RELATED [ChEBI] synonym: "P.P. factor" RELATED [NIST_Chemistry_WebBook] synonym: "pellagra preventive factor" RELATED [NIST_Chemistry_WebBook] synonym: "PP factor" RELATED [NIST_Chemistry_WebBook] synonym: "pyridine-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "pyridine-beta-carboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "pyridine-carboxylique-3" RELATED [ChemIDplus] synonym: "vitamin B3" RELATED [ChEBI] xref: AGR:IND607088605 {source="Europe PMC"} xref: Beilstein:109591 {source="Beilstein"} xref: CAS:59-67-6 {source="KEGG COMPOUND"} xref: CAS:59-67-6 {source="ChemIDplus"} xref: CAS:59-67-6 {source="NIST Chemistry WebBook"} xref: Chemspider:913 xref: Drug_Central:2835 {source="DrugCentral"} xref: DrugBank:DB00627 xref: FooDB:FDB001014 xref: Gmelin:3340 {source="Gmelin"} xref: HMDB:HMDB0001488 xref: KEGG:C00253 xref: KEGG:D00049 xref: KNApSAcK:C00000208 xref: LINCS:LSM-4676 xref: MetaCyc:NIACINE xref: PDBeChem:NIO xref: PMID:10540864 {source="Europe PMC"} xref: PMID:113218 {source="Europe PMC"} xref: PMID:12563315 {source="Europe PMC"} xref: PMID:12789870 {source="Europe PMC"} xref: PMID:135660 {source="Europe PMC"} xref: PMID:14550884 {source="Europe PMC"} xref: PMID:15037193 {source="Europe PMC"} xref: PMID:15183629 {source="Europe PMC"} xref: PMID:15205990 {source="Europe PMC"} xref: PMID:15311728 {source="Europe PMC"} xref: PMID:15627518 {source="Europe PMC"} xref: PMID:15651982 {source="Europe PMC"} xref: PMID:16018787 {source="Europe PMC"} xref: PMID:16172771 {source="Europe PMC"} xref: PMID:16322787 {source="Europe PMC"} xref: PMID:16400392 {source="Europe PMC"} xref: PMID:16449845 {source="Europe PMC"} xref: PMID:16767301 {source="Europe PMC"} xref: PMID:16877271 {source="Europe PMC"} xref: PMID:16945375 {source="Europe PMC"} xref: PMID:18037924 {source="Europe PMC"} xref: PMID:182198 {source="Europe PMC"} xref: PMID:186078 {source="Europe PMC"} xref: PMID:18993152 {source="Europe PMC"} xref: PMID:18996527 {source="Europe PMC"} xref: PMID:19369827 {source="Europe PMC"} xref: PMID:19592242 {source="Europe PMC"} xref: PMID:19678716 {source="Europe PMC"} xref: PMID:19779335 {source="Europe PMC"} xref: PMID:20979384 {source="Europe PMC"} xref: PMID:21632263 {source="Europe PMC"} xref: PMID:22116693 {source="Europe PMC"} xref: PMID:22155410 {source="Europe PMC"} xref: PMID:22229411 {source="Europe PMC"} xref: PMID:22366213 {source="Europe PMC"} xref: PMID:22458880 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:24029555 {source="Europe PMC"} xref: PMID:24568240 {source="Europe PMC"} xref: PMID:24675661 {source="Europe PMC"} xref: PMID:24848081 {source="Europe PMC"} xref: PMID:24975217 {source="Europe PMC"} xref: PMID:25040591 {source="Europe PMC"} xref: PMID:25241762 {source="Europe PMC"} xref: PMID:25429652 {source="Europe PMC"} xref: PMID:32954525 {source="Europe PMC"} xref: PMID:33273654 {source="Europe PMC"} xref: PMID:33932650 {source="Europe PMC"} xref: PMID:34066686 {source="Europe PMC"} xref: PMID:34085526 {source="Europe PMC"} xref: PMID:34117670 {source="Europe PMC"} xref: PMID:4033386 {source="Europe PMC"} xref: PMID:4259917 {source="Europe PMC"} xref: PMID:582105 {source="Europe PMC"} xref: PMID:699281 {source="Europe PMC"} xref: PMID:7217784 {source="Europe PMC"} xref: PMID:7581845 {source="Europe PMC"} xref: PMID:8306147 {source="Europe PMC"} xref: PMID:8423912 {source="Europe PMC"} xref: PMID:8679452 {source="Europe PMC"} xref: PMID:9107536 {source="Europe PMC"} xref: Reaxys:109591 {source="Reaxys"} xref: Wikipedia:Niacin is_a: CHEBI:176839 ! vitamin B3 is_a: CHEBI:26416 ! pyridine alkaloid is_a: CHEBI:26420 ! pyridinemonocarboxylic acid relationship: is_conjugate_acid_of CHEBI:32544 ! nicotinate relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent relationship: RO:0000087 CHEBI:35679 ! has role antilipemic drug relationship: RO:0000087 CHEBI:50247 ! has role antidote relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite relationship: RO:0000087 CHEBI:84264 ! has role EC 3.5.1.19 (nicotinamidase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H5NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PVNIIMVLHYAWGP-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "123.10944" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "123.03203" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1cccnc1" xsd:string [Term] id: CHEBI:15986 name: polynucleotide namespace: chebi_ontology alt_id: CHEBI:13672 alt_id: CHEBI:14859 alt_id: CHEBI:8312 def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." [] subset: 3_STAR synonym: "Polynucleotide" EXACT [KEGG_COMPOUND] synonym: "polynucleotides" RELATED [ChEBI] xref: KEGG:C00419 is_a: CHEBI:33695 ! information biomacromolecule is_a: CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_part CHEBI:50319 ! nucleotide residue property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(C5H8O6PR)n.C10H17O10PR2" xsd:string [Term] id: CHEBI:16040 name: cytosine namespace: chebi_ontology alt_id: CHEBI:14066 alt_id: CHEBI:23531 alt_id: CHEBI:4072 alt_id: CHEBI:41732 def: "An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4." [] subset: 3_STAR synonym: "4-amino-2(1H)-pyrimidinone" RELATED [NIST_Chemistry_WebBook] synonym: "4-amino-2-hydroxypyrimidine" RELATED [NIST_Chemistry_WebBook] synonym: "4-aminopyrimidin-2(1H)-one" EXACT IUPAC_NAME [IUPAC] synonym: "C" RELATED [ChEBI] synonym: "Cyt" RELATED [CBN] synonym: "Cytosin" RELATED [ChEBI] synonym: "Cytosine" EXACT [KEGG_COMPOUND] synonym: "cytosine" EXACT [UniProt] synonym: "Zytosin" RELATED [ChEBI] xref: Beilstein:2637 {source="Beilstein"} xref: CAS:71-30-7 {source="KEGG COMPOUND"} xref: CAS:71-30-7 {source="NIST Chemistry WebBook"} xref: CAS:71-30-7 {source="ChemIDplus"} xref: Gmelin:82472 {source="Gmelin"} xref: HMDB:HMDB0000630 xref: KEGG:C00380 xref: KNApSAcK:C00001498 xref: MetaCyc:CYTOSINE xref: PDBeChem:CYT xref: PMID:14253484 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:7877593 {source="Europe PMC"} xref: Reaxys:2637 {source="Reaxys"} xref: Wikipedia:Cytosine is_a: CHEBI:26432 ! pyrimidine nucleobase is_a: CHEBI:38337 ! pyrimidone is_a: CHEBI:38338 ! aminopyrimidine relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H5N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OPTASPLRGRRNAP-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "111.10212" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "111.04326" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1cc[nH]c(=O)n1" xsd:string [Term] id: CHEBI:16042 name: halide anion namespace: chebi_ontology alt_id: CHEBI:14384 alt_id: CHEBI:5605 def: "A monoatomic monoanion resulting from the addition of an electron to any halogen atom." [] subset: 3_STAR synonym: "a halide anion" RELATED [UniProt] synonym: "Halide" RELATED [KEGG_COMPOUND] synonym: "halide anions" RELATED [ChEBI] synonym: "halide ions" EXACT IUPAC_NAME [IUPAC] synonym: "halide(1-)" RELATED [ChEBI] synonym: "halides" RELATED [ChEBI] synonym: "halogen anion" RELATED [ChEBI] synonym: "HX" RELATED [KEGG_COMPOUND] xref: KEGG:C00462 is_a: CHEBI:33429 ! monoatomic monoanion is_a: CHEBI:79389 ! monovalent inorganic anion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "X" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "0.0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*-]" xsd:string [Term] id: CHEBI:16134 name: ammonia namespace: chebi_ontology alt_id: CHEBI:13405 alt_id: CHEBI:13406 alt_id: CHEBI:13407 alt_id: CHEBI:13771 alt_id: CHEBI:22533 alt_id: CHEBI:44269 alt_id: CHEBI:44284 alt_id: CHEBI:44404 alt_id: CHEBI:7434 def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." [] subset: 3_STAR synonym: "[NH3]" RELATED [MolBase] synonym: "AMMONIA" EXACT [PDBeChem] synonym: "Ammonia" EXACT [KEGG_COMPOUND] synonym: "ammonia" EXACT IUPAC_NAME [IUPAC] synonym: "ammoniac" RELATED [ChEBI] synonym: "Ammoniak" RELATED [ChemIDplus] synonym: "amoniaco" RELATED [ChEBI] synonym: "azane" EXACT IUPAC_NAME [IUPAC] synonym: "NH3" RELATED [KEGG_COMPOUND] synonym: "NH3" RELATED [UniProt] synonym: "NH3" RELATED [IUPAC] synonym: "R-717" RELATED [ChEBI] synonym: "spirit of hartshorn" RELATED [ChemIDplus] xref: Beilstein:3587154 {source="Beilstein"} xref: CAS:7664-41-7 {source="ChemIDplus"} xref: CAS:7664-41-7 {source="NIST Chemistry WebBook"} xref: CAS:7664-41-7 {source="KEGG COMPOUND"} xref: Drug_Central:4625 {source="DrugCentral"} xref: Gmelin:79 {source="Gmelin"} xref: HMDB:HMDB0000051 xref: KEGG:C00014 xref: KEGG:D02916 xref: KNApSAcK:C00007267 xref: MetaCyc:AMMONIA xref: MolBase:930 xref: PDBeChem:NH3 xref: PMID:110589 {source="Europe PMC"} xref: PMID:11139349 {source="Europe PMC"} xref: PMID:11540049 {source="Europe PMC"} xref: PMID:11746427 {source="Europe PMC"} xref: PMID:11783653 {source="Europe PMC"} xref: PMID:13753780 {source="Europe PMC"} xref: PMID:14663195 {source="Europe PMC"} xref: PMID:15092448 {source="Europe PMC"} xref: PMID:15094021 {source="Europe PMC"} xref: PMID:15554424 {source="Europe PMC"} xref: PMID:15969015 {source="Europe PMC"} xref: PMID:16008360 {source="Europe PMC"} xref: PMID:16050680 {source="Europe PMC"} xref: PMID:16348008 {source="Europe PMC"} xref: PMID:16349403 {source="Europe PMC"} xref: PMID:16614889 {source="Europe PMC"} xref: PMID:16664306 {source="Europe PMC"} xref: PMID:16842901 {source="Europe PMC"} xref: PMID:17025297 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17569513 {source="Europe PMC"} xref: PMID:17737668 {source="Europe PMC"} xref: PMID:18670398 {source="Europe PMC"} xref: PMID:22002069 {source="Europe PMC"} xref: PMID:22081570 {source="Europe PMC"} xref: PMID:22088435 {source="Europe PMC"} xref: PMID:22100291 {source="Europe PMC"} xref: PMID:22130175 {source="Europe PMC"} xref: PMID:22150211 {source="Europe PMC"} xref: PMID:22240068 {source="Europe PMC"} xref: PMID:22290316 {source="Europe PMC"} xref: PMID:22342082 {source="Europe PMC"} xref: PMID:22385337 {source="Europe PMC"} xref: PMID:22443779 {source="Europe PMC"} xref: PMID:22560242 {source="Europe PMC"} xref: Reaxys:3587154 {source="Reaxys"} xref: Wikipedia:Ammonia is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:35107 ! azane is_a: CHEBI:37176 ! mononuclear parent hydride relationship: is_conjugate_acid_of CHEBI:29337 ! azanide relationship: is_conjugate_base_of CHEBI:28938 ! ammonium relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor relationship: RO:0000087 CHEBI:78433 ! has role refrigerant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H3N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3N/h1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "17.03056" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.02655" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]N([H])[H]" xsd:string [Term] id: CHEBI:16136 name: hydrogen sulfide namespace: chebi_ontology alt_id: CHEBI:13356 alt_id: CHEBI:14414 alt_id: CHEBI:24639 alt_id: CHEBI:43058 alt_id: CHEBI:45489 alt_id: CHEBI:5787 def: "A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen." [] subset: 3_STAR synonym: "[SH2]" RELATED [MolBase] synonym: "acide sulfhydrique" RELATED [ChemIDplus] synonym: "dihydridosulfur" EXACT IUPAC_NAME [IUPAC] synonym: "dihydrogen monosulfide" RELATED [NIST_Chemistry_WebBook] synonym: "dihydrogen sulfide" RELATED [NIST_Chemistry_WebBook] synonym: "dihydrogen(sulfide)" EXACT IUPAC_NAME [IUPAC] synonym: "H2S" RELATED [IUPAC] synonym: "H2S" RELATED [KEGG_COMPOUND] synonym: "hydrogen monosulfide" RELATED [NIST_Chemistry_WebBook] synonym: "Hydrogen sulfide" EXACT [KEGG_COMPOUND] synonym: "hydrogen sulfide" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen sulphide" RELATED [ChemIDplus] synonym: "Hydrogen-sulfide" RELATED [KEGG_COMPOUND] synonym: "hydrogene sulfure" RELATED [ChemIDplus] synonym: "HYDROSULFURIC ACID" RELATED [PDBeChem] synonym: "Schwefelwasserstoff" RELATED [ChemIDplus] synonym: "sulfane" EXACT IUPAC_NAME [IUPAC] synonym: "Sulfide" RELATED [KEGG_COMPOUND] synonym: "sulfure d'hydrogene" RELATED [ChEBI] xref: Beilstein:3535004 {source="Beilstein"} xref: CAS:7783-06-4 {source="NIST Chemistry WebBook"} xref: CAS:7783-06-4 {source="ChemIDplus"} xref: CAS:7783-06-4 {source="KEGG COMPOUND"} xref: Drug_Central:4260 {source="DrugCentral"} xref: Gmelin:303 {source="Gmelin"} xref: KEGG:C00283 xref: KNApSAcK:C00007266 xref: MolBase:1709 xref: PDBeChem:H2S xref: PMID:11788560 {source="Europe PMC"} xref: PMID:14654297 {source="Europe PMC"} xref: PMID:15003943 {source="Europe PMC"} xref: PMID:15607739 {source="Europe PMC"} xref: PMID:16446402 {source="Europe PMC"} xref: PMID:18098324 {source="Europe PMC"} xref: PMID:18524810 {source="Europe PMC"} xref: PMID:18948540 {source="Europe PMC"} xref: PMID:19695225 {source="Europe PMC"} xref: PMID:22004989 {source="Europe PMC"} xref: PMID:22378060 {source="Europe PMC"} xref: PMID:22448627 {source="Europe PMC"} xref: PMID:22473176 {source="Europe PMC"} xref: PMID:22486842 {source="Europe PMC"} xref: PMID:22520971 {source="Europe PMC"} xref: PMID:22787557 {source="Europe PMC"} xref: UM-BBD_compID:c0239 {source="UM-BBD"} xref: Wikipedia:Hydrogen_sulfide is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:33405 ! hydracid is_a: CHEBI:33535 ! sulfur hydride is_a: CHEBI:37176 ! mononuclear parent hydride relationship: is_conjugate_acid_of CHEBI:29919 ! hydrosulfide relationship: is_conjugate_base_of CHEBI:30488 ! sulfonium relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent relationship: RO:0000087 CHEBI:50902 ! has role genotoxin relationship: RO:0000087 CHEBI:62488 ! has role signalling molecule relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2S/h1H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RWSOTUBLDIXVET-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "34.08188" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "33.98772" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S[H]" xsd:string [Term] id: CHEBI:16150 name: benzoate namespace: chebi_ontology alt_id: CHEBI:13879 alt_id: CHEBI:22717 def: "The simplest member of the class of benzoates that is the conjugate base of benzoic acid, comprising a benzoic acid core with a proton missing to give a charge of -1." [] subset: 3_STAR synonym: "Benzenecarboxylate" RELATED [HMDB] synonym: "Benzeneformate" RELATED [HMDB] synonym: "Benzenemethanoate" RELATED [HMDB] synonym: "benzoate" EXACT IUPAC_NAME [IUPAC] synonym: "benzoate" EXACT [UniProt] synonym: "benzoate anion" RELATED [NIST_Chemistry_WebBook] synonym: "benzoic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Phenylcarboxylate" RELATED [HMDB] synonym: "Phenylformate" RELATED [HMDB] xref: Beilstein:1862486 {source="Beilstein"} xref: CAS:766-76-7 {source="NIST Chemistry WebBook"} xref: CAS:766-76-7 {source="ChemIDplus"} xref: Gmelin:2945 {source="Gmelin"} xref: HMDB:HMDB0001870 xref: KEGG:C00180 xref: MetaCyc:BENZOATE xref: Reaxys:1862486 {source="Reaxys"} xref: UM-BBD_compID:c0121 {source="UM-BBD"} is_a: CHEBI:22718 ! benzoates relationship: is_conjugate_base_of CHEBI:30746 ! benzoic acid relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H5O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WPYMKLBDIGXBTP-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "121.11340" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "121.02950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)c1ccccc1" xsd:string [Term] id: CHEBI:161680 name: aztreonam namespace: chebi_ontology alt_id: CHEBI:2960 alt_id: CHEBI:41008 def: "A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking." [] subset: 3_STAR synonym: "(2S,3S)-3-{(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(2-carboxypropan-2-yloxy)imino]acetamido}-2-methyl-4-oxoazetidine-1-sulfonate" EXACT IUPAC_NAME [IUPAC] synonym: "(Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid" RELATED [ChemIDplus] synonym: "Azactam" RELATED BRAND_NAME [DrugBank] synonym: "AZT" RELATED [ChEBI] synonym: "aztreonam" RELATED INN [ChEBI] synonym: "aztreonamum" RELATED INN [ChemIDplus] synonym: "Primbactam" RELATED BRAND_NAME [DrugBank] xref: Beilstein:3577211 {source="Beilstein"} xref: CAS:78110-38-0 {source="ChemIDplus"} xref: Drug_Central:279 {source="DrugCentral"} xref: DrugBank:DB00355 xref: KEGG:C06840 xref: KEGG:D00240 xref: Patent:NL8100571 xref: PDBeChem:AZR xref: PMID:1384868 {source="Europe PMC"} xref: PMID:15123864 {source="Europe PMC"} xref: PMID:24119095 {source="Europe PMC"} xref: PMID:24176390 {source="Europe PMC"} xref: PMID:24369293 {source="Europe PMC"} xref: PMID:25049240 {source="Europe PMC"} xref: PMID:25091537 {source="Europe PMC"} xref: PMID:25295210 {source="Europe PMC"} xref: PMID:28543395 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:3577211 {source="Reaxys"} xref: Wikipedia:Aztreonam is_a: CHEBI:50695 ! monobactam is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50696 ! has role EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H17N5O8S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WZPBZJONDBGPKJ-VEHQQRBSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "435.43300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "435.05185" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\\c2csc([NH3+])n2)C(=O)N1S([O-])(=O)=O" xsd:string [Term] id: CHEBI:16189 name: sulfate namespace: chebi_ontology alt_id: CHEBI:15135 alt_id: CHEBI:45687 alt_id: CHEBI:9335 def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." [] subset: 3_STAR synonym: "[SO4](2-)" RELATED [IUPAC] synonym: "SO4(2-)" RELATED [IUPAC] synonym: "Sulfate" EXACT [KEGG_COMPOUND] synonym: "sulfate" EXACT [UniProt] synonym: "sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "Sulfate anion(2-)" RELATED [HMDB] synonym: "Sulfate dianion" RELATED [HMDB] synonym: "SULFATE ION" RELATED [PDBeChem] synonym: "Sulfate(2-)" RELATED [HMDB] synonym: "Sulfuric acid ion(2-)" RELATED [HMDB] synonym: "sulphate" RELATED [ChEBI] synonym: "sulphate ion" RELATED [ChEBI] synonym: "tetraoxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3648446 {source="Beilstein"} xref: CAS:14808-79-8 {source="ChemIDplus"} xref: CAS:14808-79-8 {source="NIST Chemistry WebBook"} xref: Gmelin:2120 {source="Gmelin"} xref: HMDB:HMDB0001448 xref: KEGG:C00059 xref: KEGG:D05963 xref: MetaCyc:SULFATE xref: PDBeChem:SO4 xref: PMID:11200094 {source="Europe PMC"} xref: PMID:11452993 {source="Europe PMC"} xref: PMID:11581495 {source="Europe PMC"} xref: PMID:11798107 {source="Europe PMC"} xref: PMID:12166931 {source="Europe PMC"} xref: PMID:12668033 {source="Europe PMC"} xref: PMID:14597181 {source="Europe PMC"} xref: PMID:15093386 {source="Europe PMC"} xref: PMID:15984785 {source="Europe PMC"} xref: PMID:16186560 {source="Europe PMC"} xref: PMID:16345535 {source="Europe PMC"} xref: PMID:16347366 {source="Europe PMC"} xref: PMID:16348007 {source="Europe PMC"} xref: PMID:16483812 {source="Europe PMC"} xref: PMID:16534979 {source="Europe PMC"} xref: PMID:16656509 {source="Europe PMC"} xref: PMID:16742508 {source="Europe PMC"} xref: PMID:16742518 {source="Europe PMC"} xref: PMID:17120760 {source="Europe PMC"} xref: PMID:17420092 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17709180 {source="Europe PMC"} xref: PMID:18398178 {source="Europe PMC"} xref: PMID:18815700 {source="Europe PMC"} xref: PMID:18846414 {source="Europe PMC"} xref: PMID:19047345 {source="Europe PMC"} xref: PMID:19244483 {source="Europe PMC"} xref: PMID:19544990 {source="Europe PMC"} xref: PMID:19628332 {source="Europe PMC"} xref: PMID:19812358 {source="Europe PMC"} xref: PMID:30398859 {source="Europe PMC"} xref: Reaxys:3648446 {source="Reaxys"} xref: Wikipedia:Sulfate is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06360" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95283" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S([O-])(=O)=O" xsd:string [Term] id: CHEBI:16199 name: urea namespace: chebi_ontology alt_id: CHEBI:15292 alt_id: CHEBI:27218 alt_id: CHEBI:46379 alt_id: CHEBI:9888 def: "A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O)." [] subset: 3_STAR synonym: "1728" RELATED [PPDB] synonym: "Carbamide" RELATED [KEGG_COMPOUND] synonym: "carbamide" RELATED INN [ChEBI] synonym: "carbonyldiamide" RELATED [NIST_Chemistry_WebBook] synonym: "E927b" RELATED [ChEBI] synonym: "H2NC(O)NH2" RELATED [ChEBI] synonym: "Harnstoff" RELATED [NIST_Chemistry_WebBook] synonym: "Karbamid" RELATED [ChEBI] synonym: "ur" RELATED [IUPAC] synonym: "UREA" EXACT [PDBeChem] synonym: "Urea" EXACT [KEGG_COMPOUND] synonym: "urea" EXACT [UniProt] synonym: "urea" EXACT IUPAC_NAME [IUPAC] synonym: "uree" RELATED [ChEBI] xref: Beilstein:635724 {source="Beilstein"} xref: CAS:57-13-6 {source="ChemIDplus"} xref: CAS:57-13-6 {source="NIST Chemistry WebBook"} xref: CAS:57-13-6 {source="KEGG COMPOUND"} xref: Drug_Central:4264 {source="DrugCentral"} xref: DrugBank:DB03904 xref: ECMDB:ECMDB04172 xref: Gmelin:1378 {source="Gmelin"} xref: HMDB:HMDB0000294 xref: KEGG:C00086 xref: KEGG:D00023 xref: KNApSAcK:C00007314 xref: MetaCyc:UREA xref: PDBeChem:URE xref: PMID:18037357 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PPDB:1728 xref: Reaxys:635724 {source="Reaxys"} xref: UM-BBD_compID:c0165 {source="UM-BBD"} xref: Wikipedia:Urea xref: YMDB:YMDB00003 is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:64708 ! one-carbon compound relationship: has_functional_parent CHEBI:28976 ! carbonic acid relationship: is_tautomer_of CHEBI:48376 ! carbamimidic acid relationship: RO:0000087 CHEBI:33287 ! has role fertilizer relationship: RO:0000087 CHEBI:64577 ! has role flour treatment agent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XSQUKJJJFZCRTK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.05534" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.03236" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(N)=O" xsd:string [Term] id: CHEBI:16215 name: phosphonate(2-) namespace: chebi_ontology alt_id: CHEBI:14820 alt_id: CHEBI:39856 alt_id: CHEBI:8154 def: "A divalent inorganic anion obtained by removal of both protons from phosphonic acid" [] subset: 3_STAR synonym: "[PHO3](2-)" RELATED [IUPAC] synonym: "hydridotrioxidophosphate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydridotrioxophosphate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "PHO3(2-)" RELATED [IUPAC] synonym: "PHOSPHONATE" RELATED [PDBeChem] synonym: "Phosphonate" RELATED [KEGG_COMPOUND] synonym: "phosphonate" RELATED [UniProt] synonym: "phosphonate" RELATED [IUPAC] xref: Gmelin:1618 {source="Gmelin"} xref: KEGG:C06701 xref: MetaCyc:PHOSPHONATE xref: PDBeChem:2PO is_a: CHEBI:33461 ! phosphorus oxoanion is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:33462 ! phosphonate(1-) property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O3P/c1-4(2)3/h4H,(H2,1,2,3)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ABLZXFCXXLZCGV-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "79.97990" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.96743" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]P([O-])([O-])=O" xsd:string [Term] id: CHEBI:16240 name: hydrogen peroxide namespace: chebi_ontology alt_id: CHEBI:13354 alt_id: CHEBI:13355 alt_id: CHEBI:24637 alt_id: CHEBI:44812 alt_id: CHEBI:5586 def: "An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond." [] subset: 3_STAR synonym: "[OH(OH)]" RELATED [MolBase] synonym: "bis(hydridooxygen)(O--O)" EXACT IUPAC_NAME [IUPAC] synonym: "dihydrogen dioxide" RELATED [IUPAC] synonym: "dihydrogen peroxide" EXACT IUPAC_NAME [IUPAC] synonym: "dihydrogen(peroxide)" EXACT IUPAC_NAME [IUPAC] synonym: "dioxidane" EXACT IUPAC_NAME [IUPAC] synonym: "H2O2" RELATED [UniProt] synonym: "H2O2" RELATED [KEGG_COMPOUND] synonym: "HOOH" RELATED [IUPAC] synonym: "HYDROGEN PEROXIDE" EXACT [PDBeChem] synonym: "Hydrogen peroxide" EXACT [KEGG_COMPOUND] synonym: "hydrogen peroxide" EXACT IUPAC_NAME [IUPAC] synonym: "Oxydol" RELATED [KEGG_COMPOUND] synonym: "perhydrol" RELATED [MetaCyc] xref: Beilstein:3587191 {source="Beilstein"} xref: CAS:7722-84-1 {source="KEGG COMPOUND"} xref: CAS:7722-84-1 {source="NIST Chemistry WebBook"} xref: CAS:7722-84-1 {source="ChemIDplus"} xref: Drug_Central:3281 {source="DrugCentral"} xref: Gmelin:509 {source="Gmelin"} xref: HMDB:HMDB0003125 xref: KEGG:C00027 xref: KEGG:D00008 xref: MetaCyc:HYDROGEN-PEROXIDE xref: MolBase:932 xref: PDBeChem:PEO xref: PMID:10455187 {source="Europe PMC"} xref: PMID:10557015 {source="Europe PMC"} xref: PMID:10849784 {source="Europe PMC"} xref: PMID:11033421 {source="Europe PMC"} xref: PMID:11105916 {source="Europe PMC"} xref: PMID:11318558 {source="Europe PMC"} xref: PMID:11387393 {source="Europe PMC"} xref: PMID:11809417 {source="Europe PMC"} xref: PMID:11864786 {source="Europe PMC"} xref: PMID:11893576 {source="Europe PMC"} xref: PMID:12867293 {source="Europe PMC"} xref: PMID:12934880 {source="Europe PMC"} xref: PMID:14679422 {source="Europe PMC"} xref: PMID:15028418 {source="Europe PMC"} xref: PMID:15133946 {source="Europe PMC"} xref: PMID:15298493 {source="Europe PMC"} xref: PMID:16337875 {source="Europe PMC"} xref: PMID:16463018 {source="Europe PMC"} xref: PMID:16864869 {source="Europe PMC"} xref: PMID:17020896 {source="Europe PMC"} xref: PMID:17179007 {source="Europe PMC"} xref: PMID:17610934 {source="Europe PMC"} xref: PMID:17948137 {source="Europe PMC"} xref: PMID:18179203 {source="Europe PMC"} xref: PMID:18182702 {source="Europe PMC"} xref: PMID:18306736 {source="Europe PMC"} xref: PMID:18443210 {source="Europe PMC"} xref: PMID:18592736 {source="Europe PMC"} xref: PMID:19107210 {source="Europe PMC"} xref: PMID:19229032 {source="Europe PMC"} xref: PMID:19297450 {source="Europe PMC"} xref: PMID:19509065 {source="Europe PMC"} xref: PMID:26352695 {source="Europe PMC"} xref: PMID:26365231 {source="Europe PMC"} xref: PMID:7548021 {source="Europe PMC"} xref: PMID:7581816 {source="Europe PMC"} xref: PMID:8048546 {source="Europe PMC"} xref: PMID:8375042 {source="Europe PMC"} xref: PMID:8451754 {source="Europe PMC"} xref: PMID:9051670 {source="Europe PMC"} xref: PMID:9100841 {source="Europe PMC"} xref: PMID:9168257 {source="Europe PMC"} xref: PMID:9202721 {source="Europe PMC"} xref: PMID:9558114 {source="Europe PMC"} xref: PPDB:387 xref: Reaxys:3587191 {source="Reaxys"} xref: Wikipedia:Hydrogen_peroxide is_a: CHEBI:24837 ! inorganic peroxide is_a: CHEBI:26523 ! reactive oxygen species relationship: is_conjugate_acid_of CHEBI:29192 ! hydrogenperoxide(1-) relationship: RO:0000087 CHEBI:132717 ! has role bleaching agent relationship: RO:0000087 CHEBI:149552 ! has role emetic relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:48219 ! has role disinfectant relationship: RO:0000087 CHEBI:50902 ! has role genotoxin relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:59163 ! has role biomarker relationship: RO:0000087 CHEBI:63490 ! has role explosive relationship: RO:0000087 CHEBI:65259 ! has role GABA antagonist relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O2/c1-2/h1-2H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MHAJPDPJQMAIIY-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "34.01468" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.00548" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OO[H]" xsd:string [Term] id: CHEBI:16247 name: phospholipid namespace: chebi_ontology alt_id: CHEBI:14816 alt_id: CHEBI:26063 alt_id: CHEBI:8150 def: "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." [] subset: 3_STAR synonym: "a phospholipid derivative" RELATED [UniProt] synonym: "Phospholipid" EXACT [KEGG_COMPOUND] synonym: "phospholipids" RELATED [ChEBI] xref: KEGG:C00865 is_a: CHEBI:18059 ! lipid is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester relationship: is_conjugate_acid_of CHEBI:62643 ! anionic phospholipid [Term] id: CHEBI:16313 name: D-proline namespace: chebi_ontology alt_id: CHEBI:13008 alt_id: CHEBI:21070 alt_id: CHEBI:42012 alt_id: CHEBI:42129 alt_id: CHEBI:42213 alt_id: CHEBI:4226 alt_id: CHEBI:45156 def: "The D-enantiomer of proline." [] subset: 3_STAR synonym: "(2R)-pyrrolidine-2-carboxylic acid" RELATED [IUPAC] synonym: "(R)-2-Carboxypyrrolidine" RELATED [HMDB] synonym: "(R)-pyrrolidine-2-carboxylic acid" RELATED [ChEBI] synonym: "D-Prolin" RELATED [ChEBI] synonym: "D-PROLINE" EXACT [PDBeChem] synonym: "D-Proline" EXACT [KEGG_COMPOUND] synonym: "D-proline" EXACT IUPAC_NAME [IUPAC] synonym: "DPR" RELATED [PDBeChem] xref: Beilstein:80811 {source="Beilstein"} xref: CAS:344-25-2 {source="ChemIDplus"} xref: CAS:344-25-2 {source="KEGG COMPOUND"} xref: DrugBank:DB02853 xref: Gmelin:833984 {source="Gmelin"} xref: HMDB:HMDB0003411 xref: KEGG:C00763 xref: MetaCyc:D-PROLINE xref: PDBeChem:DPR xref: PMID:19023642 {source="Europe PMC"} xref: PMID:20023020 {source="Europe PMC"} xref: PMID:20959625 {source="Europe PMC"} xref: PMID:21374575 {source="Europe PMC"} xref: PMID:21563681 {source="Europe PMC"} xref: PMID:22475019 {source="Europe PMC"} xref: PMID:22479580 {source="Europe PMC"} xref: Reaxys:80811 {source="Reaxys"} xref: Wikipedia:D-proline is_a: CHEBI:16733 ! D-alpha-amino acid is_a: CHEBI:26271 ! proline relationship: is_conjugate_acid_of CHEBI:32867 ! D-prolinate relationship: is_conjugate_base_of CHEBI:32868 ! D-prolinium relationship: is_enantiomer_of CHEBI:17203 ! L-proline relationship: is_tautomer_of CHEBI:57726 ! D-proline zwitterion relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "115.13050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "115.06333" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)[C@H]1CCCN1" xsd:string [Term] id: CHEBI:16385 name: organic sulfide namespace: chebi_ontology alt_id: CHEBI:13694 alt_id: CHEBI:26960 alt_id: CHEBI:9340 def: "Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers." [] subset: 3_STAR synonym: "organic sulfides" RELATED [ChEBI] synonym: "RSR" RELATED [IUPAC] synonym: "Sulfide" RELATED [KEGG_COMPOUND] synonym: "sulfides" EXACT IUPAC_NAME [IUPAC] synonym: "Thioether" RELATED [KEGG_COMPOUND] synonym: "thioethers" RELATED [IUPAC] xref: KEGG:C00297 is_a: CHEBI:26822 ! sulfide is_a: CHEBI:33261 ! organosulfur compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "SR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "32.066" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97207" xsd:string [Term] id: CHEBI:164200 name: triclosan namespace: chebi_ontology alt_id: CHEBI:29697 alt_id: CHEBI:47700 def: "An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes." [] subset: 3_STAR synonym: "2,4,4'-Trichloro-2'-hydroxydiphenyl ether" RELATED [ChemIDplus] synonym: "5-Chloro-2-(2,4-dichloro-phenoxy)-phenol" RELATED [ChEMBL] synonym: "5-chloro-2-(2,4-dichlorophenoxy)phenol" EXACT IUPAC_NAME [IUPAC] synonym: "Triclosan" EXACT [KEGG_COMPOUND] synonym: "triclosan" RELATED INN [ChemIDplus] synonym: "triclosan" RELATED INN [WHO_MedNet] synonym: "triclosanum" RELATED INN [ChemIDplus] xref: Beilstein:2057142 {source="Beilstein"} xref: CAS:3380-34-5 {source="KEGG COMPOUND"} xref: CAS:3380-34-5 {source="ChemIDplus"} xref: Drug_Central:3631 {source="DrugCentral"} xref: DrugBank:DB08604 xref: KEGG:C12059 xref: KEGG:D06226 xref: LINCS:LSM-2929 xref: Patent:NL6401526 xref: Patent:US3506720 xref: Patent:US3629477 xref: PDBeChem:TCL xref: PMID:11175846 {source="Europe PMC"} xref: PMID:11418506 {source="Europe PMC"} xref: PMID:15269185 {source="Europe PMC"} xref: PMID:17567585 {source="Europe PMC"} xref: PMID:18837732 {source="Europe PMC"} xref: PMID:18937596 {source="Europe PMC"} xref: PMID:19388793 {source="Europe PMC"} xref: PMID:21094257 {source="Europe PMC"} xref: PMID:21166831 {source="Europe PMC"} xref: PMID:21833630 {source="Europe PMC"} xref: PMID:22105314 {source="Europe PMC"} xref: PMID:22561896 {source="Europe PMC"} xref: PMID:22746545 {source="Europe PMC"} xref: PMID:23146048 {source="Europe PMC"} xref: PMID:23161706 {source="Europe PMC"} xref: PMID:23192912 {source="Europe PMC"} xref: PMID:23282071 {source="Europe PMC"} xref: PMID:23313217 {source="Europe PMC"} xref: PMID:23320506 {source="Europe PMC"} xref: PMID:23368947 {source="Europe PMC"} xref: PMID:23435526 {source="Europe PMC"} xref: PMID:23561013 {source="Europe PMC"} xref: PMID:23592331 {source="Europe PMC"} xref: PMID:23614034 {source="Europe PMC"} xref: PMID:23648333 {source="Europe PMC"} xref: PMID:23791346 {source="Europe PMC"} xref: PMID:23831729 {source="Europe PMC"} xref: PMID:23890965 {source="Europe PMC"} xref: PMID:23927454 {source="Europe PMC"} xref: PMID:24079913 {source="Europe PMC"} xref: PMID:25179274 {source="Europe PMC"} xref: PMID:28236114 {source="Europe PMC"} xref: PMID:28339349 {source="Europe PMC"} xref: PMID:28632490 {source="Europe PMC"} xref: PMID:28741979 {source="Europe PMC"} xref: PMID:29030459 {source="Europe PMC"} xref: PMID:29067681 {source="Europe PMC"} xref: PMID:29100157 {source="Europe PMC"} xref: PMID:29109308 {source="Europe PMC"} xref: PMID:29111213 {source="Europe PMC"} xref: PMID:29111444 {source="Europe PMC"} xref: PMID:29131715 {source="Europe PMC"} xref: PMID:29150338 {source="Europe PMC"} xref: PMID:29154092 {source="Europe PMC"} xref: PMID:29172042 {source="Europe PMC"} xref: PMID:29175687 {source="Europe PMC"} xref: PMID:29197580 {source="Europe PMC"} xref: PMID:29205483 {source="Europe PMC"} xref: PMID:29214481 {source="Europe PMC"} xref: PMID:29232866 {source="Europe PMC"} xref: PMID:29277667 {source="Europe PMC"} xref: PMID:29332277 {source="Europe PMC"} xref: PMID:29340711 {source="Europe PMC"} xref: PMID:29348637 {source="Europe PMC"} xref: Reaxys:2057142 {source="Reaxys"} xref: Wikipedia:Triclosan is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:33853 ! phenols is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:83403 ! monochlorobenzenes relationship: RO:0000087 CHEBI:139512 ! has role EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor relationship: RO:0000087 CHEBI:24127 ! has role fungicide relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:38068 ! has role antimalarial relationship: RO:0000087 CHEBI:50683 ! has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor relationship: RO:0000087 CHEBI:77853 ! has role persistent organic pollutant relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H7Cl3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XEFQLINVKFYRCS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "289.54200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "287.95116" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl" xsd:string [Term] id: CHEBI:16541 name: protein polypeptide chain namespace: chebi_ontology alt_id: CHEBI:8526 def: "A naturally occurring polypeptide synthesized at the ribosome." [] subset: 3_STAR synonym: "a protein" RELATED [UniProt] synonym: "polypeptide chain" RELATED [ChEBI] synonym: "Protein" RELATED [KEGG_COMPOUND] synonym: "protein polypeptide chains" RELATED [ChEBI] xref: KEGG:C00017 is_a: CHEBI:15841 ! polypeptide relationship: has_part CHEBI:33700 ! proteinogenic amino-acid residue [Term] id: CHEBI:16646 name: carbohydrate namespace: chebi_ontology alt_id: CHEBI:15131 alt_id: CHEBI:23008 alt_id: CHEBI:9318 def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." [] subset: 3_STAR synonym: "a carbohydrate" RELATED [UniProt] synonym: "carbohidrato" RELATED [IUPAC] synonym: "carbohidratos" RELATED [IUPAC] synonym: "carbohydrate" EXACT IUPAC_NAME [IUPAC] synonym: "carbohydrates" EXACT IUPAC_NAME [IUPAC] synonym: "glucide" RELATED [ChEBI] synonym: "glucides" RELATED [ChEBI] synonym: "glucido" RELATED [ChEBI] synonym: "glucidos" RELATED [ChEBI] synonym: "hydrates de carbone" RELATED [ChEBI] synonym: "Kohlenhydrat" RELATED [ChEBI] synonym: "Kohlenhydrate" RELATED [ChEBI] synonym: "saccharide" RELATED [IUPAC] synonym: "saccharides" RELATED [IUPAC] synonym: "saccharidum" RELATED [ChEBI] xref: Wikipedia:Carbohydrate is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16670 name: peptide namespace: chebi_ontology alt_id: CHEBI:14753 alt_id: CHEBI:25906 alt_id: CHEBI:7990 def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." [] subset: 3_STAR synonym: "Peptid" RELATED [ChEBI] synonym: "Peptide" EXACT [KEGG_COMPOUND] synonym: "peptides" EXACT IUPAC_NAME [IUPAC] synonym: "peptido" RELATED [ChEBI] synonym: "peptidos" RELATED [ChEBI] xref: KEGG:C00012 is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:50047 ! organic amino compound relationship: has_part CHEBI:33708 ! amino-acid residue relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(C2H2NOR)nC2H3NOR" xsd:string [Term] id: CHEBI:16704 name: uridine namespace: chebi_ontology alt_id: CHEBI:15296 alt_id: CHEBI:27227 alt_id: CHEBI:46386 alt_id: CHEBI:46391 alt_id: CHEBI:46460 alt_id: CHEBI:9893 def: "A ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N(1)-glycosidic bond." [] subset: 3_STAR synonym: "1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione" RELATED [ChEBI] synonym: "1-beta-D-ribofuranosyluracil" RELATED [HMDB] synonym: "beta-Uridine" RELATED [HMDB] synonym: "u" RELATED [ChEBI] synonym: "Urd" RELATED [CBN] synonym: "Uridin" RELATED [ChemIDplus] synonym: "URIDINE" EXACT [PDBeChem] synonym: "Uridine" EXACT [KEGG_COMPOUND] synonym: "uridine" EXACT IUPAC_NAME [IUPAC] synonym: "uridine" EXACT [UniProt] xref: Beilstein:754904 {source="Beilstein"} xref: CAS:58-96-8 {source="ChemIDplus"} xref: CAS:58-96-8 {source="KEGG COMPOUND"} xref: DrugBank:DB02745 xref: ECMDB:ECMDB00296 xref: Gmelin:397474 {source="Gmelin"} xref: HMDB:HMDB0000296 xref: KEGG:C00299 xref: KNApSAcK:C00019674 xref: MetaCyc:URIDINE xref: PDBeChem:URI xref: PMID:12084455 {source="Europe PMC"} xref: PMID:15621516 {source="Europe PMC"} xref: PMID:16839635 {source="Europe PMC"} xref: PMID:17190852 {source="Europe PMC"} xref: PMID:22392515 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: Reaxys:754904 {source="Reaxys"} xref: Wikipedia:Uridine xref: YMDB:YMDB00127 is_a: CHEBI:27242 ! uridines relationship: RO:0000087 CHEBI:49103 ! has role drug metabolite relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12N2O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DRTQHJPVMGBUCF-XVFCMESISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "244.20146" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "244.06954" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:16705 name: 6-aminopenicillanic acid namespace: chebi_ontology alt_id: CHEBI:20705 alt_id: CHEBI:2172 def: "A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and pharmacologic characteristics." [] subset: 3_STAR synonym: "(+)-6-aminopenicillanic acid" RELATED [ChEBI] synonym: "(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6-amino-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "6-Aminopenicillamine acid" RELATED [ChemIDplus] synonym: "6-Aminopenicillanate" RELATED [KEGG_COMPOUND] synonym: "6-Aminopenicillanic acid" EXACT [KEGG_COMPOUND] synonym: "6-APA" RELATED [ChEBI] synonym: "6-Apa" RELATED [ChemIDplus] synonym: "6-Aps" RELATED [ChemIDplus] synonym: "6beta-aminopenicillanic acid" RELATED [ChEBI] synonym: "Aminopenicillanic acid" RELATED [ChemIDplus] synonym: "Penicin" RELATED [ChemIDplus] synonym: "Penin" RELATED [ChemIDplus] synonym: "Phenacyl 6-aminopenicillinate" RELATED [ChemIDplus] xref: Beilstein:15080 {source="Beilstein"} xref: Beilstein:959078 {source="Beilstein"} xref: CAS:551-16-6 {source="ChemIDplus"} xref: CAS:551-16-6 {source="KEGG COMPOUND"} xref: Gmelin:1876702 {source="Gmelin"} xref: KEGG:C02954 xref: Patent:US2941995 xref: PDBeChem:X1E xref: PMID:12569987 {source="Europe PMC"} xref: PMID:1384868 {source="Europe PMC"} xref: PMID:14687482 {source="Europe PMC"} xref: PMID:1701026 {source="Europe PMC"} xref: PMID:20970923 {source="Europe PMC"} xref: PMID:21614893 {source="Europe PMC"} xref: PMID:24293403 {source="Europe PMC"} xref: PMID:24389703 {source="Europe PMC"} xref: PMID:24631718 {source="Europe PMC"} xref: PMID:25057428 {source="Europe PMC"} xref: PMID:26852849 {source="Europe PMC"} xref: PMID:26986755 {source="Europe PMC"} xref: PMID:6166603 {source="Europe PMC"} xref: Reaxys:15080 {source="Reaxys"} xref: Wikipedia:6-APA is_a: CHEBI:25865 ! penicillanic acids relationship: has_functional_parent CHEBI:37806 ! penicillanic acid relationship: is_conjugate_base_of CHEBI:30938 ! 6-aminopenicillanate relationship: is_tautomer_of CHEBI:57869 ! 6-aminopenicillanic acid zwitterion relationship: RO:0000087 CHEBI:50904 ! has role allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H12N2O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H12N2O3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,9H2,1-2H3,(H,12,13)/t3-,4+,6-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NGHVIOIJCVXTGV-ALEPSDHESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "216.260" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "216.05686" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C([C@H]1C(S[C@@]2([C@@H](C(N12)=O)N)[H])(C)C)(O)=O" xsd:string [Term] id: CHEBI:16716 name: benzene namespace: chebi_ontology alt_id: CHEBI:13876 alt_id: CHEBI:22703 alt_id: CHEBI:3025 alt_id: CHEBI:41187 def: "A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system." [] subset: 3_STAR synonym: "[6]annulene" RELATED [NIST_Chemistry_WebBook] synonym: "Benzen" RELATED [IUPAC] synonym: "BENZENE" EXACT [PDBeChem] synonym: "Benzene" EXACT [KEGG_COMPOUND] synonym: "benzene" EXACT IUPAC_NAME [IUPAC] synonym: "benzene" EXACT [UniProt] synonym: "benzene" EXACT [ChEBI] synonym: "Benzine" RELATED [UM-BBD] synonym: "Benzol" RELATED [ChemIDplus] synonym: "benzole" RELATED [NIST_Chemistry_WebBook] synonym: "Bicarburet of hydrogen" RELATED [ChemIDplus] synonym: "Coal naphtha" RELATED [ChemIDplus] synonym: "cyclohexatriene" RELATED [UM-BBD] synonym: "Mineral naphtha" RELATED [ChemIDplus] synonym: "Phene" RELATED [ChemIDplus] synonym: "phenyl hydride" RELATED [UM-BBD] synonym: "Pyrobenzol" RELATED [ChemIDplus] synonym: "Pyrobenzole" RELATED [ChemIDplus] xref: Beilstein:969212 {source="Beilstein"} xref: CAS:71-43-2 {source="ChemIDplus"} xref: CAS:71-43-2 {source="NIST Chemistry WebBook"} xref: CAS:71-43-2 {source="KEGG COMPOUND"} xref: Gmelin:1671 {source="Gmelin"} xref: HMDB:HMDB0001505 xref: KEGG:C01407 xref: PDBeChem:BNZ xref: PMID:11684179 {source="Europe PMC"} xref: PMID:11993966 {source="Europe PMC"} xref: PMID:12857942 {source="Europe PMC"} xref: PMID:14677922 {source="Europe PMC"} xref: PMID:15468289 {source="Europe PMC"} xref: PMID:15935818 {source="Europe PMC"} xref: PMID:16161967 {source="Europe PMC"} xref: PMID:17373369 {source="Europe PMC"} xref: PMID:18072742 {source="Europe PMC"} xref: PMID:18407866 {source="Europe PMC"} xref: PMID:18409691 {source="Europe PMC"} xref: PMID:18836923 {source="Europe PMC"} xref: PMID:19228219 {source="Europe PMC"} xref: PMID:21325737 {source="Europe PMC"} xref: PMID:23088855 {source="Europe PMC"} xref: PMID:23222815 {source="Europe PMC"} xref: PMID:23534829 {source="Europe PMC"} xref: PMID:6353911 {source="Europe PMC"} xref: PMID:8124204 {source="Europe PMC"} xref: Reaxys:969212 {source="Reaxys"} xref: UM-BBD_compID:c0142 {source="UM-BBD"} xref: Wikipedia:Benzene is_a: CHEBI:134179 ! volatile organic compound is_a: CHEBI:22712 ! benzenes is_a: CHEBI:33842 ! aromatic annulene relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H6/c1-2-4-6-5-3-1/h1-6H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UHOVQNZJYSORNB-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "78.11184" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "78.04695" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccccc1" xsd:string [Term] id: CHEBI:167164 name: mineral nutrient namespace: chebi_ontology def: "A mineral that is an inorganic nutrient which must be ingested and absorbed in adequate amounts to satisfy a wide range of essential metabolic and/or structural functions in the human body." [] subset: 3_STAR synonym: "mineral nutrient" EXACT [ChEBI] synonym: "mineral nutrients" RELATED [ChEBI] synonym: "nutrient mineral" RELATED [ChEBI] synonym: "nutrient minerals" RELATED [ChEBI] xref: Wikipedia:Mineral_(nutrient) is_a: CHEBI:46662 ! mineral relationship: RO:0000087 CHEBI:33284 ! has role nutrient [Term] id: CHEBI:167183 name: piscicide namespace: chebi_ontology def: "A substance which is poisonous to fish and is primarily used to eliminate dominant species of fish in water." [] subset: 3_STAR synonym: "piscicides" RELATED [ChEBI] xref: Wikipedia:Piscicide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:16733 name: D-alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:12909 alt_id: CHEBI:13625 alt_id: CHEBI:20906 alt_id: CHEBI:4097 subset: 3_STAR synonym: "D-alpha-amino acid" EXACT [ChEBI] synonym: "D-alpha-amino acids" EXACT IUPAC_NAME [IUPAC] synonym: "D-alpha-amino acids" RELATED [ChEBI] synonym: "D-Amino acid" RELATED [KEGG_COMPOUND] xref: KEGG:C00405 is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid relationship: is_conjugate_acid_of CHEBI:60895 ! D-alpha-amino acid anion relationship: is_tautomer_of CHEBI:59871 ! D-alpha-amino acid zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H]([*])C(O)=O" xsd:string [Term] id: CHEBI:167559 name: glycan namespace: chebi_ontology def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." [] subset: 3_STAR synonym: "glycans" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16914 name: salicylic acid namespace: chebi_ontology alt_id: CHEBI:26597 alt_id: CHEBI:45521 alt_id: CHEBI:9006 def: "A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves." [] subset: 3_STAR synonym: "2-carboxyphenol" RELATED [NIST_Chemistry_WebBook] synonym: "2-HYDROXYBENZOIC ACID" RELATED [PDBeChem] synonym: "2-hydroxybenzoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "o-carboxyphenol" RELATED [NIST_Chemistry_WebBook] synonym: "o-Hydroxybenzoic acid" RELATED [KEGG_COMPOUND] synonym: "o-hydroxybenzoic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Salicylic acid" EXACT [KEGG_COMPOUND] xref: Beilstein:774890 {source="Beilstein"} xref: CAS:69-72-7 {source="ChemIDplus"} xref: CAS:69-72-7 {source="NIST Chemistry WebBook"} xref: CAS:69-72-7 {source="KEGG COMPOUND"} xref: Drug_Central:2416 {source="DrugCentral"} xref: DrugBank:DB00936 xref: Gmelin:3418 {source="Gmelin"} xref: HMDB:HMDB0001895 xref: KEGG:C00805 xref: KEGG:D00097 xref: KNApSAcK:C00000206 xref: LINCS:LSM-4763 xref: MetaCyc:CPD-110 xref: PDBeChem:SAL xref: PMID:11016405 {source="Europe PMC"} xref: PMID:12865403 {source="Europe PMC"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:19400653 {source="Europe PMC"} xref: PMID:19816125 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:29079364 {source="Europe PMC"} xref: PMID:32807953 {source="Europe PMC"} xref: PMID:3425858 {source="Europe PMC"} xref: Reaxys:774890 {source="Reaxys"} xref: Wikipedia:Salicylic_Acid is_a: CHEBI:25389 ! monohydroxybenzoic acid relationship: is_conjugate_acid_of CHEBI:30762 ! salicylate relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:37848 ! has role plant hormone relationship: RO:0000087 CHEBI:50176 ! has role keratolytic drug relationship: RO:0000087 CHEBI:73181 ! has role EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YGSDEFSMJLZEOE-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "138.12070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "138.03169" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1ccccc1O" xsd:string [Term] id: CHEBI:16976 name: hygromycin B namespace: chebi_ontology alt_id: CHEBI:14426 alt_id: CHEBI:24752 alt_id: CHEBI:43202 alt_id: CHEBI:5821 subset: 3_STAR synonym: "(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-beta-D-talopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "Antibiotic A-396-II" RELATED [KEGG_COMPOUND] synonym: "HYGROMYCIN B" EXACT [PDBeChem] synonym: "Hygromycin B" EXACT [KEGG_COMPOUND] synonym: "O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N(3)-methyl-D-streptamine" RELATED [ChEBI] xref: Beilstein:6755837 {source="Beilstein"} xref: CAS:31282-04-9 {source="ChemIDplus"} xref: CAS:31282-04-9 {source="KEGG COMPOUND"} xref: KEGG:C01925 xref: PDBeChem:HYG is_a: CHEBI:24753 ! hygromycin is_a: CHEBI:71989 ! ortho ester relationship: is_conjugate_base_of CHEBI:57971 ! hygromycin B(3+) relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H37N3O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6?,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GRRNUXAQVGOGFE-NZSRVPFOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "527.52010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "527.23264" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3O[C@@]4(O[C@H](C(N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O" xsd:string [Term] id: CHEBI:17029 name: chitin namespace: chebi_ontology alt_id: CHEBI:13962 alt_id: CHEBI:23099 alt_id: CHEBI:3596 def: "An aminoglycan consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [] subset: 3_STAR synonym: "(1->4)-2-acetamido-2-deoxy-beta-D-glucan" EXACT IUPAC_NAME [IUPAC] synonym: "[1,4-(N-Acetyl-beta-D-glucosaminyl)]n" RELATED [KEGG_COMPOUND] synonym: "[4)-beta-D-GlcpNAc(1->]n" RELATED [IUPAC] synonym: "beta-1,4-Poly-N-acetyl-D-glucosamine" RELATED [KEGG_COMPOUND] synonym: "Chitin" EXACT [KEGG_COMPOUND] synonym: "chitin" EXACT [IUPAC] synonym: "chitin" EXACT [UniProt] xref: CAS:1398-61-4 {source="KEGG COMPOUND"} xref: KEGG:C00461 xref: KEGG:G10483 is_a: CHEBI:21638 ! N-acylglucosamine is_a: CHEBI:22506 ! aminoglycan relationship: RO:0000087 CHEBI:73336 ! has role vulnerary relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O(C8H13NO5)n" xsd:string [Term] id: CHEBI:17076 name: streptomycin namespace: chebi_ontology alt_id: CHEBI:15119 alt_id: CHEBI:26784 alt_id: CHEBI:45745 alt_id: CHEBI:9284 def: "A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class" [] subset: 3_STAR synonym: "2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside" RELATED [ChemIDplus] synonym: "[2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}" RELATED [IUPAC] synonym: "Kantrex" RELATED BRAND_NAME [DrugBank] synonym: "N,N'''-[(1R,2R,3S,4R,5R,6S)-4-{5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranosyloxy}-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine" EXACT IUPAC_NAME [IUPAC] synonym: "SM" RELATED [KEGG_DRUG] synonym: "streomycin" RELATED [ChEBI] synonym: "STREPTOMYCIN" EXACT [PDBeChem] synonym: "streptomycin" RELATED INN [KEGG_DRUG] xref: Beilstein:74498 {source="Beilstein"} xref: CAS:57-92-1 {source="KEGG COMPOUND"} xref: CAS:57-92-1 {source="ChemIDplus"} xref: Drug_Central:2481 {source="DrugCentral"} xref: DrugBank:DB01082 xref: HMDB:HMDB0015214 xref: KEGG:C00413 xref: KEGG:D08531 xref: MetaCyc:STREPTOMYCIN xref: PDBeChem:SRY xref: Pesticides:streptomycin {source="Alan Wood's Pesticides"} xref: PMID:11228320 {source="Europe PMC"} xref: PMID:11905029 {source="Europe PMC"} xref: PMID:12118520 {source="Europe PMC"} xref: PMID:13030054 {source="Europe PMC"} xref: PMID:13116094 {source="Europe PMC"} xref: PMID:13136149 {source="Europe PMC"} xref: PMID:13596285 {source="Europe PMC"} xref: PMID:13691614 {source="Europe PMC"} xref: PMID:13985260 {source="Europe PMC"} xref: PMID:13990247 {source="Europe PMC"} xref: PMID:14623118 {source="Europe PMC"} xref: PMID:14828344 {source="Europe PMC"} xref: PMID:14852338 {source="Europe PMC"} xref: PMID:14939639 {source="Europe PMC"} xref: PMID:15081082 {source="Europe PMC"} xref: PMID:15137533 {source="Europe PMC"} xref: PMID:15207172 {source="Europe PMC"} xref: PMID:15686853 {source="Europe PMC"} xref: PMID:15736038 {source="Europe PMC"} xref: PMID:16904706 {source="Europe PMC"} xref: PMID:17105735 {source="Europe PMC"} xref: PMID:17238915 {source="Europe PMC"} xref: PMID:17429930 {source="Europe PMC"} xref: PMID:18173084 {source="Europe PMC"} xref: PMID:18916143 {source="Europe PMC"} xref: PMID:19052412 {source="Europe PMC"} xref: PMID:19335957 {source="Europe PMC"} xref: PMID:21350946 {source="Europe PMC"} xref: PMID:21362244 {source="Europe PMC"} xref: PMID:21593257 {source="Europe PMC"} xref: PMID:21937264 {source="Europe PMC"} xref: PMID:22101040 {source="Europe PMC"} xref: Reaxys:74498 {source="Reaxys"} xref: Wikipedia:Streptomycin is_a: CHEBI:26788 ! streptomycins is_a: CHEBI:87113 ! antibiotic antifungal drug is_a: CHEBI:87114 ! antibiotic fungicide relationship: has_functional_parent CHEBI:27405 ! streptidine relationship: is_conjugate_base_of CHEBI:58007 ! streptomycin(3+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H39N7O12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCSJYZPVAKXKNQ-HZYVHMACSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "581.57434" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "581.26567" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@@H](O[C@@H](C)[C@]1(O)C=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]1NC(N)=N" xsd:string [Term] id: CHEBI:17087 name: ketone namespace: chebi_ontology alt_id: CHEBI:13427 alt_id: CHEBI:13646 alt_id: CHEBI:24974 alt_id: CHEBI:6127 alt_id: CHEBI:8742 def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." [] subset: 3_STAR synonym: "a ketone" RELATED [UniProt] synonym: "cetone" RELATED [ChEBI] synonym: "Keton" RELATED [ChEBI] synonym: "Ketone" EXACT [KEGG_COMPOUND] synonym: "ketones" EXACT IUPAC_NAME [IUPAC] synonym: "ketones" RELATED [ChEBI] synonym: "R-CO-R'" RELATED [KEGG_COMPOUND] xref: KEGG:C01450 xref: Wikipedia:Ketone is_a: CHEBI:36586 ! carbonyl compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "COR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "28.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C([*])=O" xsd:string [Term] id: CHEBI:17137 name: hydrogensulfite namespace: chebi_ontology alt_id: CHEBI:13367 alt_id: CHEBI:5598 subset: 3_STAR synonym: "[SO2(OH)](-)" RELATED [IUPAC] synonym: "Bisulfite" RELATED [KEGG_COMPOUND] synonym: "bisulfite" RELATED [ChemIDplus] synonym: "bisulphite" RELATED [ChemIDplus] synonym: "HSO3(-)" RELATED [IUPAC] synonym: "HSO3-" RELATED [KEGG_COMPOUND] synonym: "Hydrogen sulfite" RELATED [KEGG_COMPOUND] synonym: "hydrogen sulfite(1-)" RELATED [ChemIDplus] synonym: "hydrogen(trioxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogensulfite(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxosulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxosulfate(IV)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrosulfite anion" RELATED [ChemIDplus] synonym: "hydroxidodioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "monohydrogentrioxosulfate" EXACT IUPAC_NAME [IUPAC] xref: CAS:15181-46-1 {source="KEGG COMPOUND"} xref: CAS:15181-46-1 {source="ChemIDplus"} xref: Gmelin:1455 {source="Gmelin"} xref: KEGG:C11481 xref: PDBeChem:SO3 is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_acid_of CHEBI:17359 ! sulfite relationship: is_conjugate_base_of CHEBI:48854 ! sulfurous acid relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96519" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS([O-])=O" xsd:string [Term] id: CHEBI:17154 name: nicotinamide namespace: chebi_ontology alt_id: CHEBI:14645 alt_id: CHEBI:25521 alt_id: CHEBI:44258 alt_id: CHEBI:7556 def: "A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group." [] subset: 3_STAR synonym: "3-carbamoylpyridine" RELATED [ChemIDplus] synonym: "3-pyridinecarboxamide" RELATED [NIST_Chemistry_WebBook] synonym: "beta-pyridinecarboxamide" RELATED [ChemIDplus] synonym: "beta-pyridinecarboxamide" RELATED [NIST_Chemistry_WebBook] synonym: "m-(aminocarbonyl)pyridine" RELATED [ChemIDplus] synonym: "niacin" RELATED [ChEBI] synonym: "Niacinamide" RELATED [KEGG_COMPOUND] synonym: "niamide" RELATED [ChemIDplus] synonym: "Nicotinamid" RELATED [ChEBI] synonym: "nicotinamida" RELATED INN [WHO_MedNet] synonym: "nicotinamide" EXACT [UniProt] synonym: "nicotinamide" RELATED INN [WHO_MedNet] synonym: "nicotinamidum" RELATED INN [WHO_MedNet] synonym: "nicotine acid amide" RELATED [ChemIDplus] synonym: "nicotine amide" RELATED [ChemIDplus] synonym: "nicotinic acid amide" RELATED [ChemIDplus] synonym: "nicotinic amide" RELATED [ChemIDplus] synonym: "Nicotinsaeureamid" RELATED [ChEBI] synonym: "nicotylamide" RELATED [ChemIDplus] synonym: "Nikotinamid" RELATED [ChemIDplus] synonym: "Nikotinsaeureamid" RELATED [ChEBI] synonym: "pyridine-3-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "pyridine-3-carboxylic acid amide" RELATED [ChemIDplus] synonym: "vitamin B3" RELATED [ChemIDplus] synonym: "Vitamin PP" RELATED [KEGG_COMPOUND] xref: Beilstein:383619 {source="Beilstein"} xref: CAS:98-92-0 {source="ChemIDplus"} xref: CAS:98-92-0 {source="NIST Chemistry WebBook"} xref: CAS:98-92-0 {source="KEGG COMPOUND"} xref: Drug_Central:1906 {source="DrugCentral"} xref: DrugBank:DB02701 xref: FooDB:FDB012485 xref: Gmelin:3336 {source="Gmelin"} xref: HMDB:HMDB0001406 xref: KEGG:C00153 xref: KEGG:D00036 xref: KNApSAcK:C00000209 xref: LINCS:LSM-5428 xref: MetaCyc:NIACINAMIDE xref: Patent:US2904552 xref: Patent:US2993051 xref: PDBeChem:NCA xref: PMID:10884473 {source="Europe PMC"} xref: PMID:11355130 {source="Europe PMC"} xref: PMID:11814060 {source="Europe PMC"} xref: PMID:12014919 {source="Europe PMC"} xref: PMID:12487919 {source="Europe PMC"} xref: PMID:12519385 {source="Europe PMC"} xref: PMID:12709297 {source="Europe PMC"} xref: PMID:12782109 {source="Europe PMC"} xref: PMID:12890690 {source="Europe PMC"} xref: PMID:14729974 {source="Europe PMC"} xref: PMID:14757966 {source="Europe PMC"} xref: PMID:14871431 {source="Europe PMC"} xref: PMID:15497767 {source="Europe PMC"} xref: PMID:15563975 {source="Europe PMC"} xref: PMID:15780941 {source="Europe PMC"} xref: PMID:15807725 {source="Europe PMC"} xref: PMID:15834926 {source="Europe PMC"} xref: PMID:15995937 {source="Europe PMC"} xref: PMID:16029679 {source="Europe PMC"} xref: PMID:16209160 {source="Europe PMC"} xref: PMID:16596767 {source="Europe PMC"} xref: PMID:16766489 {source="Europe PMC"} xref: PMID:16871361 {source="Europe PMC"} xref: PMID:17021258 {source="Europe PMC"} xref: PMID:17129213 {source="Europe PMC"} xref: PMID:18234191 {source="Europe PMC"} xref: PMID:18316796 {source="Europe PMC"} xref: PMID:18368629 {source="Europe PMC"} xref: PMID:18373238 {source="Europe PMC"} xref: PMID:18389009 {source="Europe PMC"} xref: PMID:18514428 {source="Europe PMC"} xref: PMID:18930755 {source="Europe PMC"} xref: PMID:18987186 {source="Europe PMC"} xref: PMID:19212411 {source="Europe PMC"} xref: PMID:19539713 {source="Europe PMC"} xref: PMID:19544437 {source="Europe PMC"} xref: PMID:2026685 {source="Europe PMC"} xref: PMID:21503886 {source="Europe PMC"} xref: PMID:21891976 {source="Europe PMC"} xref: PMID:21918528 {source="Europe PMC"} xref: PMID:21926578 {source="Europe PMC"} xref: PMID:22067079 {source="Europe PMC"} xref: PMID:22160932 {source="Europe PMC"} xref: PMID:22207684 {source="Europe PMC"} xref: PMID:22232263 {source="Europe PMC"} xref: PMID:22281243 {source="Europe PMC"} xref: PMID:22359146 {source="Europe PMC"} xref: PMID:22361740 {source="Europe PMC"} xref: PMID:22407380 {source="Europe PMC"} xref: PMID:22456321 {source="Europe PMC"} xref: PMID:22536229 {source="Europe PMC"} xref: PMID:22543086 {source="Europe PMC"} xref: PMID:22626821 {source="Europe PMC"} xref: PMID:22699421 {source="Europe PMC"} xref: PMID:22709272 {source="Europe PMC"} xref: PMID:22763693 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: PMID:23016598 {source="Europe PMC"} xref: PMID:23028781 {source="Europe PMC"} xref: PMID:23043891 {source="Europe PMC"} xref: PMID:23047329 {source="Europe PMC"} xref: PMID:24027187 {source="Europe PMC"} xref: PMID:24077178 {source="Europe PMC"} xref: PMID:24559077 {source="Europe PMC"} xref: PMID:24635573 {source="Europe PMC"} xref: PMID:25504347 {source="Europe PMC"} xref: PMID:25561219 {source="Europe PMC"} xref: PMID:31710686 {source="Europe PMC"} xref: PMID:32249824 {source="Europe PMC"} xref: PMID:33196157 {source="Europe PMC"} xref: PMID:33471934 {source="Europe PMC"} xref: PMID:8620561 {source="Europe PMC"} xref: PMID:8767167 {source="Europe PMC"} xref: PMID:9518388 {source="Europe PMC"} xref: Reaxys:383619 {source="Reaxys"} xref: Wikipedia:Nicotinamide is_a: CHEBI:176839 ! vitamin B3 is_a: CHEBI:25529 ! pyridinecarboxamide is_a: CHEBI:26416 ! pyridine alkaloid relationship: has_functional_parent CHEBI:15940 ! nicotinic acid relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:22586 ! has role antioxidant relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:62913 ! has role EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent relationship: RO:0000087 CHEBI:71181 ! has role Sir2 inhibitor relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DFPAKSUCGFBDDF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "122.12472" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "122.04801" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)c1cccnc1" xsd:string [Term] id: CHEBI:171664 name: antiamoebic agent namespace: chebi_ontology def: "An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae." [] subset: 3_STAR synonym: "amebicide" RELATED [ChEBI] synonym: "amebicides" RELATED [ChEBI] synonym: "amoebicide" RELATED [ChEBI] synonym: "amoebicides" RELATED [ChEBI] synonym: "anti-amoebic agent" RELATED [ChEBI] synonym: "anti-amoebic agents" RELATED [ChEBI] synonym: "anti-amoebic drug" RELATED [ChEBI] synonym: "anti-amoebic drugs" RELATED [ChEBI] synonym: "antiamoebic" RELATED [ChEBI] synonym: "antiamoebic agents" RELATED [ChEBI] synonym: "antiamoebic drug" RELATED [ChEBI] synonym: "antiamoebic drugs" RELATED [ChEBI] synonym: "antiamoebics" RELATED [ChEBI] is_a: CHEBI:35442 ! antiparasitic agent [Term] id: CHEBI:17203 name: L-proline namespace: chebi_ontology alt_id: CHEBI:13154 alt_id: CHEBI:184637 alt_id: CHEBI:21373 alt_id: CHEBI:42067 alt_id: CHEBI:45040 alt_id: CHEBI:45100 alt_id: CHEBI:45159 alt_id: CHEBI:6286 def: "Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles." [] subset: 3_STAR synonym: "(-)-(S)-proline" RELATED [NIST_Chemistry_WebBook] synonym: "(-)-2-pyrrolidinecarboxylic acid" RELATED [ChemIDplus] synonym: "(-)-proline" RELATED [ChemIDplus] synonym: "(2S)-pyrrolidine-2-carboxylic acid" RELATED [IUPAC] synonym: "(S)-2-carboxypyrrolidine" RELATED [DrugBank] synonym: "(S)-2-pyrrolidinecarboxylic acid" RELATED [ChemIDplus] synonym: "(S)-pyrrolidine-2-carboxylic acid" RELATED [ChEBI] synonym: "2-Pyrrolidinecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "L-(-)-proline" RELATED [NIST_Chemistry_WebBook] synonym: "L-alpha-pyrrolidinecarboxylic acid" RELATED [ChemIDplus] synonym: "L-Prolin" RELATED [ChEBI] synonym: "L-Proline" EXACT [KEGG_COMPOUND] synonym: "L-proline" EXACT IUPAC_NAME [IUPAC] synonym: "L-pyrrolidine-2-carboxylic acid" RELATED [ChemIDplus] synonym: "P" RELATED [ChEBI] synonym: "prolina" RELATED [ChemIDplus] synonym: "PROLINE" RELATED [PDBeChem] synonym: "proline" RELATED INN [ChemIDplus] synonym: "prolinum" RELATED [ChemIDplus] xref: Beilstein:80810 {source="Beilstein"} xref: CAS:147-85-3 {source="NIST Chemistry WebBook"} xref: CAS:147-85-3 {source="ChemIDplus"} xref: CAS:147-85-3 {source="KEGG COMPOUND"} xref: Drug_Central:4125 {source="DrugCentral"} xref: DrugBank:DB00172 xref: Gmelin:50152 {source="Gmelin"} xref: HMDB:HMDB0000162 xref: KEGG:C00148 xref: KEGG:D00035 xref: KNApSAcK:C00001388 xref: MetaCyc:PRO xref: PDBeChem:PRO xref: PMID:11076505 {source="Europe PMC"} xref: PMID:12770004 {source="Europe PMC"} xref: PMID:14975886 {source="Europe PMC"} xref: PMID:15576824 {source="Europe PMC"} xref: PMID:15838615 {source="Europe PMC"} xref: PMID:15894682 {source="Europe PMC"} xref: PMID:15973048 {source="Europe PMC"} xref: PMID:16033917 {source="Europe PMC"} xref: PMID:16190672 {source="Europe PMC"} xref: PMID:16501220 {source="Europe PMC"} xref: PMID:16656443 {source="Europe PMC"} xref: PMID:16657874 {source="Europe PMC"} xref: PMID:16668324 {source="Europe PMC"} xref: PMID:17127472 {source="Europe PMC"} xref: PMID:17608428 {source="Europe PMC"} xref: PMID:18551589 {source="Europe PMC"} xref: PMID:18802692 {source="Europe PMC"} xref: PMID:18973300 {source="Europe PMC"} xref: PMID:19215998 {source="Europe PMC"} xref: PMID:19580280 {source="Europe PMC"} xref: PMID:19656302 {source="Europe PMC"} xref: PMID:19688381 {source="Europe PMC"} xref: PMID:19811425 {source="Europe PMC"} xref: PMID:22139509 {source="Europe PMC"} xref: PMID:22201772 {source="Europe PMC"} xref: PMID:22451406 {source="Europe PMC"} xref: PMID:22475019 {source="Europe PMC"} xref: PMID:22482728 {source="Europe PMC"} xref: PMID:22491679 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: Reaxys:80810 {source="Reaxys"} xref: Wikipedia:L-proline is_a: CHEBI:24318 ! glutamine family amino acid is_a: CHEBI:26271 ! proline relationship: is_conjugate_acid_of CHEBI:32862 ! L-prolinate relationship: is_conjugate_base_of CHEBI:32864 ! L-prolinium relationship: is_enantiomer_of CHEBI:16313 ! D-proline relationship: is_tautomer_of CHEBI:60039 ! L-proline zwitterion relationship: RO:0000087 CHEBI:23366 ! has role compatible osmolytes relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "115.13050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "115.06333" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)[C@@H]1CCCN1" xsd:string [Term] id: CHEBI:17234 name: glucose namespace: chebi_ontology alt_id: CHEBI:14313 alt_id: CHEBI:24277 alt_id: CHEBI:33929 alt_id: CHEBI:5418 def: "An aldohexose used as a source of energy and metabolic intermediate." [] subset: 3_STAR synonym: "DL-glucose" RELATED [ChEBI] synonym: "Glc" RELATED [JCBN] synonym: "gluco-hexose" EXACT IUPAC_NAME [IUPAC] synonym: "Glucose" EXACT [KEGG_COMPOUND] synonym: "glucose" EXACT IUPAC_NAME [IUPAC] synonym: "Glukose" RELATED [ChEBI] xref: CAS:50-99-7 {source="KEGG COMPOUND"} xref: KEGG:C00293 xref: Wikipedia:Glucose is_a: CHEBI:33917 ! aldohexose relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string [Term] id: CHEBI:17296 name: aniline namespace: chebi_ontology alt_id: CHEBI:13834 alt_id: CHEBI:22561 alt_id: CHEBI:2732 alt_id: CHEBI:40796 def: "A primary arylamine in which an amino functional group is substituted for one of the benzene hydrogens." [] subset: 3_STAR synonym: "aminobenzene" RELATED [ChemIDplus] synonym: "aminophen" RELATED [ChemIDplus] synonym: "Anilin" RELATED [NIST_Chemistry_WebBook] synonym: "ANILINE" EXACT [PDBeChem] synonym: "Aniline" EXACT [KEGG_COMPOUND] synonym: "aniline" EXACT [UniProt] synonym: "aniline" EXACT IUPAC_NAME [IUPAC] synonym: "Benzenamine" RELATED [KEGG_COMPOUND] synonym: "benzeneamine" RELATED [NIST_Chemistry_WebBook] synonym: "kyanol" RELATED [NIST_Chemistry_WebBook] synonym: "Phenylamine" RELATED [KEGG_COMPOUND] xref: Beilstein:605631 {source="Beilstein"} xref: CAS:62-53-3 {source="NIST Chemistry WebBook"} xref: CAS:62-53-3 {source="ChemIDplus"} xref: CAS:62-53-3 {source="KEGG COMPOUND"} xref: DrugBank:DB06728 xref: Gmelin:2796 {source="Gmelin"} xref: HMDB:HMDB0003012 xref: KEGG:C00292 xref: MetaCyc:ANILINE xref: PDBeChem:ANL xref: PMID:11304127 {source="Europe PMC"} xref: PMID:17135213 {source="Europe PMC"} xref: PMID:23821252 {source="Europe PMC"} xref: PMID:3779628 {source="Europe PMC"} xref: PMID:6205897 {source="Europe PMC"} xref: Reaxys:605631 {source="Reaxys"} xref: Wikipedia:Aniline is_a: CHEBI:22562 ! anilines is_a: CHEBI:50471 ! primary arylamine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H7N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H7N/c7-6-4-2-1-3-5-6/h1-5H,7H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PAYRUJLWNCNPSJ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "93.12650" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "93.05785" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ccccc1" xsd:string [Term] id: CHEBI:173084 name: ferroptosis inhibitor namespace: chebi_ontology def: "Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." [] subset: 3_STAR synonym: "ferroptosis inhibitors" RELATED [ChEBI] xref: PMID:32015325 {source="SUBMITTER"} xref: PMID:32256352 {source="Europe PMC"} xref: PMID:32413317 {source="Europe PMC"} xref: PMID:33495651 {source="Europe PMC"} xref: Wikipedia:Ferroptosis is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:17334 name: penicillin namespace: chebi_ontology alt_id: CHEBI:14742 alt_id: CHEBI:25869 alt_id: CHEBI:7961 def: "Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6." [] subset: 3_STAR synonym: "Penicillin" EXACT [KEGG_COMPOUND] synonym: "penicillins" EXACT IUPAC_NAME [IUPAC] synonym: "penicillins" RELATED [ChEBI] xref: KEGG:C00395 xref: PMID:11851248 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:1502708 {source="Europe PMC"} xref: PMID:16033609 {source="Europe PMC"} xref: PMID:7061385 {source="Europe PMC"} xref: PMID:7798534 {source="Europe PMC"} xref: Wikipedia:Penicillin is_a: CHEBI:25865 ! penicillanic acids relationship: has_functional_parent CHEBI:16705 ! 6-aminopenicillanic acid relationship: is_conjugate_acid_of CHEBI:51356 ! penicillinate anion relationship: RO:0000087 CHEBI:50904 ! has role allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11N2O4SR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "243.26000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "243.04395" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC([*])=O)C(O)=O" xsd:string [Term] id: CHEBI:17359 name: sulfite namespace: chebi_ontology alt_id: CHEBI:15139 alt_id: CHEBI:45548 def: "A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3)." [] subset: 3_STAR synonym: "[SO3](2-)" RELATED [IUPAC] synonym: "SO3" RELATED [ChEBI] synonym: "SO3(2-)" RELATED [IUPAC] synonym: "sulfite" EXACT IUPAC_NAME [IUPAC] synonym: "sulfite" EXACT [UniProt] synonym: "SULFITE ION" RELATED [PDBeChem] synonym: "sulphite" RELATED [ChEBI] synonym: "trioxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "trioxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "trioxosulfate(IV)" EXACT IUPAC_NAME [IUPAC] xref: CAS:14265-45-3 {source="ChemIDplus"} xref: Gmelin:1449 {source="Gmelin"} xref: PDBeChem:SO3 is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:17137 ! hydrogensulfite property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "80.06420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.95791" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S([O-])=O" xsd:string [Term] id: CHEBI:17418 name: valeric acid namespace: chebi_ontology alt_id: CHEBI:113448 alt_id: CHEBI:27263 alt_id: CHEBI:27264 alt_id: CHEBI:43606 alt_id: CHEBI:44803 alt_id: CHEBI:7980 def: "A straight-chain saturated fatty acid containing five carbon atoms." [] subset: 3_STAR synonym: "1-butanecarboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "1-butanecarboxylic acid" RELATED [ChemIDplus] synonym: "CH3-[CH2]3-COOH" RELATED [IUPAC] synonym: "n-BuCOOH" RELATED [ChEBI] synonym: "n-Pentanoate" RELATED [KEGG_COMPOUND] synonym: "n-pentanoic acid" RELATED [ChemIDplus] synonym: "n-Valeric acid" RELATED [KEGG_COMPOUND] synonym: "n-valeric acid" RELATED [ChemIDplus] synonym: "Pentanoate" RELATED [KEGG_COMPOUND] synonym: "PENTANOIC ACID" RELATED [PDBeChem] synonym: "Pentanoic acid" RELATED [KEGG_COMPOUND] synonym: "pentanoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "pentoic acid" RELATED [ChEBI] synonym: "propylacetic acid" RELATED [ChemIDplus] synonym: "Valerate" RELATED [KEGG_COMPOUND] synonym: "Valerianic acid" RELATED [KEGG_COMPOUND] synonym: "Valeriansaeure" RELATED [ChEBI] synonym: "Valeric acid" EXACT [KEGG_COMPOUND] synonym: "valeric acid, normal" RELATED [ChemIDplus] xref: Beilstein:969454 {source="Beilstein"} xref: CAS:109-52-4 {source="ChemIDplus"} xref: CAS:109-52-4 {source="NIST Chemistry WebBook"} xref: CAS:109-52-4 {source="KEGG COMPOUND"} xref: DrugBank:DB02406 xref: Gmelin:26714 {source="Gmelin"} xref: HMDB:HMDB0000892 xref: KEGG:C00803 xref: KNApSAcK:C00001208 xref: LIPID_MAPS_instance:LMFA01010005 {source="LIPID MAPS"} xref: PDBeChem:LEA xref: PMID:20507156 {source="Europe PMC"} xref: PPDB:3130 xref: Reaxys:969454 {source="Reaxys"} xref: Wikipedia:Valeric_acid is_a: CHEBI:26666 ! short-chain fatty acid is_a: CHEBI:39418 ! straight-chain saturated fatty acid relationship: is_conjugate_acid_of CHEBI:31011 ! valerate relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NQPDZGIKBAWPEJ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "102.13170" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.06808" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCC(O)=O" xsd:string [Term] id: CHEBI:17478 name: aldehyde namespace: chebi_ontology alt_id: CHEBI:13432 alt_id: CHEBI:13753 alt_id: CHEBI:13805 alt_id: CHEBI:13806 alt_id: CHEBI:22291 alt_id: CHEBI:2554 alt_id: CHEBI:8750 def: "A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group." [] subset: 3_STAR synonym: "aldehido" RELATED [ChEBI] synonym: "aldehidos" RELATED [ChEBI] synonym: "Aldehyd" RELATED [ChEBI] synonym: "Aldehyde" EXACT [KEGG_COMPOUND] synonym: "aldehyde" EXACT [ChEBI] synonym: "aldehyde" EXACT IUPAC_NAME [IUPAC] synonym: "aldehydes" EXACT IUPAC_NAME [IUPAC] synonym: "aldehydes" RELATED [ChEBI] synonym: "aldehydum" RELATED [ChEBI] synonym: "an aldehyde" RELATED [UniProt] synonym: "RC(=O)H" RELATED [IUPAC] synonym: "RCHO" RELATED [KEGG_COMPOUND] xref: KEGG:C00071 is_a: CHEBI:36586 ! carbonyl compound relationship: has_part CHEBI:42485 ! formyl group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHOR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "29.01800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([*])=O" xsd:string [Term] id: CHEBI:17489 name: 3',5'-cyclic AMP namespace: chebi_ontology alt_id: CHEBI:11673 alt_id: CHEBI:1325 alt_id: CHEBI:19827 alt_id: CHEBI:41588 def: "A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase." [] subset: 3_STAR synonym: "3',5'-Cyclic AMP" EXACT [KEGG_COMPOUND] synonym: "adenosine 3',5'-(hydrogen phosphate)" EXACT IUPAC_NAME [IUPAC] synonym: "adenosine 3',5'-cyclic monophosphate" RELATED [NIST_Chemistry_WebBook] synonym: "Adenosine 3',5'-cyclic phosphate" RELATED [KEGG_COMPOUND] synonym: "Adenosine 3',5'-phosphate" RELATED [KEGG_COMPOUND] synonym: "ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE" RELATED [PDBeChem] synonym: "cAMP" RELATED [KEGG_COMPOUND] synonym: "Cyclic adenylic acid" RELATED [KEGG_COMPOUND] synonym: "Cyclic AMP" RELATED [KEGG_COMPOUND] xref: Beilstein:52645 {source="Beilstein"} xref: CAS:60-92-4 {source="KEGG COMPOUND"} xref: CAS:60-92-4 {source="NIST Chemistry WebBook"} xref: CAS:60-92-4 {source="ChemIDplus"} xref: DrugBank:DB02527 xref: HMDB:HMDB0000058 xref: KEGG:C00575 xref: KNApSAcK:C00001497 xref: MetaCyc:CAMP xref: PDBeChem:CMP xref: PMID:16295522 {source="Europe PMC"} xref: PMID:18372334 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: Reaxys:52645 {source="Reaxys"} xref: Wikipedia:Cyclic_AMP is_a: CHEBI:19834 ! 3',5'-cyclic purine nucleotide is_a: CHEBI:61296 ! adenyl ribonucleotide relationship: is_conjugate_acid_of CHEBI:58165 ! 3',5'-cyclic AMP(1-) relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H12N5O6P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IVOMOUWHDPKRLL-KQYNXXCUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "329.20614" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "329.05252" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O" xsd:string [Term] id: CHEBI:17499 name: hydrogen donor namespace: chebi_ontology alt_id: CHEBI:13233 alt_id: CHEBI:15018 alt_id: CHEBI:8785 def: "A molecular entity that can undergo oxidation by the loss of hydrogen atom(s)." [] subset: 3_STAR synonym: "AH2" RELATED [UniProt] synonym: "AH2" RELATED [KEGG_COMPOUND] synonym: "Donor" RELATED [KEGG_COMPOUND] synonym: "Hydrogen-donor" RELATED [KEGG_COMPOUND] synonym: "Reduced acceptor" RELATED [KEGG_COMPOUND] xref: KEGG:C00030 is_a: CHEBI:15022 ! electron donor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "RH2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "2.016" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "2.01565" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*([H])[H]" xsd:string [Term] id: CHEBI:17514 name: cyanide namespace: chebi_ontology alt_id: CHEBI:14038 alt_id: CHEBI:3969 alt_id: CHEBI:41780 def: "A pseudohalide anion that is the conjugate base of hydrogen cyanide." [] subset: 3_STAR synonym: "CN(-)" RELATED [IUPAC] synonym: "CN-" RELATED [KEGG_COMPOUND] synonym: "Cyanide" EXACT [KEGG_COMPOUND] synonym: "Cyanide" EXACT [ChEBI] synonym: "cyanide" EXACT IUPAC_NAME [IUPAC] synonym: "CYANIDE ION" RELATED [PDBeChem] synonym: "nitridocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "Prussiate" RELATED [KEGG_COMPOUND] synonym: "Zyanid" RELATED [ChEBI] xref: Beilstein:1900509 {source="Beilstein"} xref: CAS:57-12-5 {source="ChemIDplus"} xref: CAS:57-12-5 {source="NIST Chemistry WebBook"} xref: CAS:57-12-5 {source="KEGG COMPOUND"} xref: Gmelin:89 {source="Gmelin"} xref: HMDB:HMDB0002084 xref: KEGG:C00177 xref: MetaCyc:CPD-13584 xref: PDBeChem:CYN xref: PMID:11386635 {source="Europe PMC"} xref: PMID:14871577 {source="Europe PMC"} xref: PMID:17554165 {source="Europe PMC"} xref: PMID:7839575 {source="Europe PMC"} xref: Reaxys:1900509 {source="Reaxys"} xref: Wikipedia:Cyanide is_a: CHEBI:36828 ! pseudohalide anion relationship: is_conjugate_base_of CHEBI:18407 ! hydrogen cyanide relationship: is_conjugate_base_of CHEBI:36856 ! hydrogen isocyanide relationship: RO:0000087 CHEBI:38500 ! has role EC 1.9.3.1 (cytochrome c oxidase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CN" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CN/c1-2/q-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XFXPMWWXUTWYJX-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "26.01740" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "26.00362" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C-]#N" xsd:string [Term] id: CHEBI:17522 name: alditol namespace: chebi_ontology alt_id: CHEBI:13754 alt_id: CHEBI:22298 alt_id: CHEBI:2556 def: "A carbohydrate that is an acyclic polyol having the general formula HOCH2[CH(OH)]nCH2OH (formally derivable from an aldose by reduction of the carbonyl group)." [] subset: 3_STAR synonym: "Alditol" EXACT [KEGG_COMPOUND] synonym: "alditol" EXACT [UniProt] synonym: "alditols" RELATED [ChEBI] synonym: "Glycitol" RELATED [KEGG_COMPOUND] synonym: "Sugar alcohol" RELATED [KEGG_COMPOUND] xref: KEGG:C00717 xref: Wikipedia:Glycerin is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:26191 ! polyol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(CH2O)nC2H6O2" xsd:string [Term] id: CHEBI:17544 name: hydrogencarbonate namespace: chebi_ontology alt_id: CHEBI:13363 alt_id: CHEBI:22863 alt_id: CHEBI:40961 alt_id: CHEBI:5589 def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." [] subset: 3_STAR synonym: "[CO2(OH)](-)" RELATED [IUPAC] synonym: "Acid carbonate" RELATED [KEGG_COMPOUND] synonym: "Bicarbonate" RELATED [KEGG_COMPOUND] synonym: "BICARBONATE ION" RELATED [PDBeChem] synonym: "HCO3(-)" RELATED [IUPAC] synonym: "HCO3-" RELATED [KEGG_COMPOUND] synonym: "hydrogen carbonate" RELATED [PDBeChem] synonym: "hydrogen(trioxidocarbonate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND] synonym: "hydrogencarbonate" EXACT [UniProt] synonym: "hydrogencarbonate" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogencarbonate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentrioxocarbonate(IV)" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidodioxidocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3903504 {source="Beilstein"} xref: CAS:71-52-3 {source="ChemIDplus"} xref: Gmelin:49249 {source="Gmelin"} xref: HMDB:HMDB0000595 xref: KEGG:C00288 xref: MetaCyc:HCO3 xref: PDBeChem:BCT xref: PMID:17215880 {source="Europe PMC"} xref: PMID:17505962 {source="Europe PMC"} xref: PMID:18439416 {source="Europe PMC"} xref: PMID:28732801 {source="Europe PMC"} xref: PMID:29150416 {source="Europe PMC"} xref: PMID:29460248 {source="Europe PMC"} xref: PMID:29466234 {source="Europe PMC"} xref: PMID:4208463 {source="Europe PMC"} xref: Wikipedia:Bicarbonate is_a: CHEBI:35604 ! carbon oxoanion relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "61.01684" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.99312" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([O-])=O" xsd:string [Term] id: CHEBI:17568 name: uracil namespace: chebi_ontology alt_id: CHEBI:15288 alt_id: CHEBI:27210 alt_id: CHEBI:46375 alt_id: CHEBI:9882 def: "A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription." [] subset: 3_STAR synonym: "2,4(1H,3H)-pyrimidinedione" RELATED [NIST_Chemistry_WebBook] synonym: "2,4-Dioxopyrimidine" RELATED [HMDB] synonym: "2,4-Pyrimidinedione" RELATED [HMDB] synonym: "pyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC] synonym: "U" RELATED [ChEBI] synonym: "Ura" RELATED [CBN] synonym: "URACIL" EXACT [PDBeChem] synonym: "Uracil" EXACT [KEGG_COMPOUND] synonym: "uracil" EXACT [UniProt] synonym: "Urazil" RELATED [ChEBI] xref: Beilstein:606623 {source="Beilstein"} xref: CAS:66-22-8 {source="NIST Chemistry WebBook"} xref: CAS:66-22-8 {source="KEGG COMPOUND"} xref: CAS:66-22-8 {source="ChemIDplus"} xref: DrugBank:DB03419 xref: Gmelin:2896 {source="Gmelin"} xref: HMDB:HMDB0000300 xref: KEGG:C00106 xref: KEGG:D00027 xref: KNApSAcK:C00001513 xref: MetaCyc:URACIL xref: PDBeChem:URA xref: PMID:11279060 {source="Europe PMC"} xref: PMID:12855717 {source="Europe PMC"} xref: PMID:15274295 {source="Europe PMC"} xref: PMID:16834123 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:18533995 {source="Europe PMC"} xref: PMID:18815805 {source="Europe PMC"} xref: PMID:19175333 {source="Europe PMC"} xref: PMID:22020693 {source="Europe PMC"} xref: PMID:22074393 {source="Europe PMC"} xref: PMID:22120518 {source="Europe PMC"} xref: PMID:22171528 {source="Europe PMC"} xref: PMID:22237209 {source="Europe PMC"} xref: PMID:22299724 {source="Europe PMC"} xref: PMID:22356544 {source="Europe PMC"} xref: PMID:22447672 {source="Europe PMC"} xref: PMID:22483865 {source="Europe PMC"} xref: PMID:22567906 {source="Europe PMC"} xref: PMID:22685418 {source="Europe PMC"} xref: PMID:3654008 {source="Europe PMC"} xref: Reaxys:606623 {source="Reaxys"} xref: Wikipedia:Uracil is_a: CHEBI:26432 ! pyrimidine nucleobase is_a: CHEBI:38337 ! pyrimidone relationship: is_tautomer_of CHEBI:43254 ! (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one relationship: RO:0000087 CHEBI:50266 ! has role prodrug relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H4N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ISAKRJDGNUQOIC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "112.08684" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "112.02728" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=c1cc[nH]c(=O)[nH]1" xsd:string [Term] id: CHEBI:17608 name: D-aldohexose namespace: chebi_ontology alt_id: CHEBI:12990 alt_id: CHEBI:21038 def: "Any D-aldose having a chain of six carbon atoms in the molecule." [] subset: 3_STAR synonym: "D-aldohexoses" RELATED [ChEBI] is_a: CHEBI:33917 ! aldohexose is_a: CHEBI:4194 ! D-hexose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string [Term] id: CHEBI:17630 name: kanamycin A namespace: chebi_ontology alt_id: CHEBI:14487 alt_id: CHEBI:24945 alt_id: CHEBI:24947 alt_id: CHEBI:43482 alt_id: CHEBI:6106 subset: 3_STAR synonym: "(1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside" RELATED [ChemIDplus] synonym: "4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside" RELATED [ChemIDplus] synonym: "KANAMYCIN A" EXACT [PDBeChem] synonym: "Kanamycin A" EXACT [KEGG_COMPOUND] synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine" RELATED [ChemIDplus] xref: Beilstein:61647 {source="Beilstein"} xref: CAS:59-01-8 {source="KEGG COMPOUND"} xref: CAS:59-01-8 {source="ChemIDplus"} xref: Drug_Central:1519 {source="DrugCentral"} xref: DrugBank:DB01172 xref: Gmelin:2044856 {source="Gmelin"} xref: KEGG:C01822 xref: LINCS:LSM-5261 xref: PDBeChem:KAN xref: PMID:22907688 {source="Europe PMC"} xref: PMID:24336356 {source="Europe PMC"} xref: PMID:24566637 {source="Europe PMC"} xref: VSDB:1921 xref: Wikipedia:Kanamycin is_a: CHEBI:24951 ! kanamycins relationship: is_conjugate_base_of CHEBI:58214 ! kanamycin A(4+) relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H36N4O11" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SBUJHOSQTJFQJX-NOAMYHISSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "484.49860" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "484.23806" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:17634 name: D-glucose namespace: chebi_ontology alt_id: CHEBI:12965 alt_id: CHEBI:20999 def: "A glucose with D-configuration." [] subset: 3_STAR synonym: "D(+)-glucose" RELATED [ChemIDplus] synonym: "D-(+)-glucose" RELATED [NIST_Chemistry_WebBook] synonym: "D-gluco-hexose" EXACT IUPAC_NAME [IUPAC] synonym: "D-glucose" EXACT IUPAC_NAME [IUPAC] synonym: "dextrose" RELATED [NIST_Chemistry_WebBook] synonym: "grape sugar" RELATED [ChemIDplus] synonym: "Traubenzucker" RELATED [ChemIDplus] xref: CAS:50-99-7 {source="NIST Chemistry WebBook"} xref: CAS:50-99-7 {source="ChemIDplus"} is_a: CHEBI:17234 ! glucose is_a: CHEBI:17608 ! D-aldohexose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string [Term] id: CHEBI:176497 name: geroprotector namespace: chebi_ontology def: "Any compound that supports healthy aging, slows the biological aging process, or extends lifespan." [] subset: 3_STAR synonym: "anti-aging agent" RELATED [ChEBI] synonym: "anti-aging agents" RELATED [ChEBI] synonym: "anti-aging drug" RELATED [ChEBI] synonym: "anti-aging drugs" RELATED [ChEBI] synonym: "geroprotective agent" RELATED [ChEBI] synonym: "geroprotective agents" RELATED [ChEBI] synonym: "geroprotectors" RELATED [ChEBI] xref: PMID:23372317 {source="Europe PMC"} xref: PMID:28580190 {source="Europe PMC"} xref: PMID:30885572 {source="Europe PMC"} xref: PMID:33144142 {source="Europe PMC"} xref: PMID:33973253 {source="Europe PMC"} xref: PMID:34606237 {source="Europe PMC"} xref: Wikipedia:Geroprotector is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:17658 name: tylosin namespace: chebi_ontology alt_id: CHEBI:15275 alt_id: CHEBI:27172 alt_id: CHEBI:46150 alt_id: CHEBI:9787 def: "A macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae." [] subset: 3_STAR synonym: "[(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-3-(dimethylamino)-beta-D-glucopyranosyloxy]-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "tilosina" RELATED INN [ChemIDplus] synonym: "Tylan" RELATED [ChemIDplus] synonym: "Tylocine" RELATED [ChemIDplus] synonym: "Tylosin" EXACT [KEGG_COMPOUND] synonym: "tylosin" RELATED INN [ChemIDplus] synonym: "Tylosin A" RELATED [ChemIDplus] synonym: "tylosine" RELATED INN [ChemIDplus] synonym: "tylosinum" RELATED INN [ChemIDplus] xref: CAS:1401-69-0 {source="ChemIDplus"} xref: CAS:1401-69-0 {source="KEGG COMPOUND"} xref: HMDB:HMDB0034108 xref: KEGG:C01457 xref: KEGG:D02490 xref: LIPID_MAPS_instance:LMPK04000004 {source="LIPID MAPS"} xref: MetaCyc:TYLOSIN xref: Patent:US2004082524 xref: PDBeChem:TYK xref: PMID:18836909 {source="Europe PMC"} xref: PMID:23013044 {source="Europe PMC"} xref: PMID:23352520 {source="Europe PMC"} xref: PMID:23397987 {source="Europe PMC"} xref: PMID:23398744 {source="Europe PMC"} xref: PMID:23928021 {source="Europe PMC"} xref: PMID:23985521 {source="Europe PMC"} xref: PMID:24063615 {source="Europe PMC"} xref: PMID:24113548 {source="Europe PMC"} xref: PMID:24201036 {source="Europe PMC"} xref: PMID:24270892 {source="Europe PMC"} xref: PMID:24393633 {source="Europe PMC"} xref: PMID:7867337 {source="Europe PMC"} xref: Reaxys:4651020 {source="Reaxys"} xref: Wikipedia:Tylosin is_a: CHEBI:17478 ! aldehyde is_a: CHEBI:25022 ! leucomycin is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:51689 ! enone is_a: CHEBI:63353 ! disaccharide derivative is_a: CHEBI:63367 ! monosaccharide derivative relationship: has_functional_parent CHEBI:29700 ! tylactone relationship: is_conjugate_base_of CHEBI:77047 ! tylosin(1+) relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C46H77NO17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WBPYTXDJUQJLPQ-VMXQISHHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "916.10010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "915.51915" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\\C=C\\C(\\C)=C\\[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC" xsd:string [Term] id: CHEBI:176839 name: vitamin B3 namespace: chebi_ontology def: "Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms)." [] subset: 3_STAR synonym: "vitamin B-3" RELATED [ChEBI] synonym: "vitamin B3" EXACT [ChEBI] synonym: "vitamin B3 vitamer" RELATED [ChEBI] synonym: "vitamin B3 vitamers" RELATED [ChEBI] synonym: "vitamins B3" RELATED [ChEBI] is_a: CHEBI:75769 ! B vitamin [Term] id: CHEBI:17698 name: chloramphenicol namespace: chebi_ontology alt_id: CHEBI:13965 alt_id: CHEBI:23106 alt_id: CHEBI:23108 alt_id: CHEBI:3603 alt_id: CHEBI:47327 def: "An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions." [] subset: 3_STAR synonym: "(-)-chloramphenicol" RELATED [ChEBI] synonym: "2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide" EXACT IUPAC_NAME [IUPAC] synonym: "Amphicol" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Chloramex" RELATED BRAND_NAME [ChemIDplus] synonym: "CHLORAMPHENICOL" EXACT [PDBeChem] synonym: "Chloramphenicol" EXACT [KEGG_COMPOUND] synonym: "chloramphenicol" EXACT [UniProt] synonym: "chloramphenicol" RELATED INN [WHO_MedNet] synonym: "chloramphenicolum" RELATED INN [WHO_MedNet] synonym: "chlornitromycin" RELATED [ChEBI] synonym: "Chlorocid" RELATED BRAND_NAME [ChemIDplus] synonym: "Chlorocol" RELATED BRAND_NAME [ChemIDplus] synonym: "Chloromycetin" RELATED BRAND_NAME [ChemIDplus] synonym: "cloramfenicol" RELATED INN [WHO_MedNet] synonym: "D-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide" RELATED [ChemIDplus] synonym: "D-(-)-threo-1-p-nitrophenyl-2-dichloroacetylamino-1,3-propanediol" RELATED [ChemIDplus] synonym: "Econochlor" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Fenicol" RELATED BRAND_NAME [ChemIDplus] synonym: "Globenicol" RELATED BRAND_NAME [ChemIDplus] synonym: "Halomycetin" RELATED BRAND_NAME [ChemIDplus] synonym: "laevomycetinum" RELATED [ChemIDplus] synonym: "levomicetina" RELATED [ChemIDplus] synonym: "levomycetin" RELATED [ChemIDplus] synonym: "Oleomycetin" RELATED BRAND_NAME [ChemIDplus] synonym: "Sificetina" RELATED BRAND_NAME [ChemIDplus] xref: Beilstein:2225532 {source="Beilstein"} xref: CAS:56-75-7 {source="NIST Chemistry WebBook"} xref: CAS:56-75-7 {source="ChemIDplus"} xref: Chemspider:5744 xref: Drug_Central:589 {source="DrugCentral"} xref: DrugBank:DB00446 xref: HMDB:HMDB0014589 xref: KEGG:C00918 xref: KEGG:D00104 xref: LINCS:LSM-5256 xref: MetaCyc:CHLORAMPHENICOL xref: Patent:GB795131 xref: Patent:GB796901 xref: Patent:US2483871 xref: Patent:US2483884 xref: Patent:US2483892 xref: Patent:US2839577 xref: PDBeChem:CLM xref: Pesticides:chloramphenicol {source="Alan Wood's Pesticides"} xref: PMID:11468347 {source="Europe PMC"} xref: PMID:12217690 {source="Europe PMC"} xref: PMID:16659995 {source="Europe PMC"} xref: PMID:16897441 {source="Europe PMC"} xref: PMID:17217404 {source="Europe PMC"} xref: PMID:17692887 {source="Europe PMC"} xref: PMID:17963326 {source="Europe PMC"} xref: PMID:18559535 {source="Europe PMC"} xref: PMID:18657290 {source="Europe PMC"} xref: PMID:18794387 {source="Europe PMC"} xref: PMID:23142491 {source="Europe PMC"} xref: PMID:23317719 {source="Europe PMC"} xref: PMID:23395526 {source="Europe PMC"} xref: PMID:23494278 {source="Europe PMC"} xref: PMID:23512826 {source="Europe PMC"} xref: PMID:23698443 {source="Europe PMC"} xref: PMID:657786 {source="Europe PMC"} xref: PMID:6653106 {source="Europe PMC"} xref: PMID:7040026 {source="Europe PMC"} xref: VSDB:1835 xref: Wikipedia:Chloramphenicol is_a: CHEBI:23824 ! diol is_a: CHEBI:35716 ! C-nitro compound is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:37622 ! carboxamide relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C11H12Cl2N2O5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WIIZWVCIJKGZOK-RKDXNWHRSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "323.130" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "322.01233" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C([C@H]([C@H](NC(C(Cl)Cl)=O)CO)O)C=CC(=C1)[N+]([O-])=O" xsd:string [Term] id: CHEBI:17790 name: methanol namespace: chebi_ontology alt_id: CHEBI:14588 alt_id: CHEBI:25227 alt_id: CHEBI:44080 alt_id: CHEBI:44553 alt_id: CHEBI:6816 def: "The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group." [] subset: 3_STAR synonym: "carbinol" RELATED [ChemIDplus] synonym: "CH3OH" RELATED [ChEBI] synonym: "MeOH" RELATED [ChEBI] synonym: "METHANOL" EXACT [PDBeChem] synonym: "Methanol" EXACT [KEGG_COMPOUND] synonym: "methanol" EXACT [UniProt] synonym: "methanol" EXACT IUPAC_NAME [IUPAC] synonym: "Methyl alcohol" RELATED [KEGG_COMPOUND] synonym: "Methylalkohol" RELATED [NIST_Chemistry_WebBook] synonym: "spirit of wood" RELATED [HMDB] synonym: "wood alcohol" RELATED [ChemIDplus] synonym: "wood naphtha" RELATED [ChemIDplus] synonym: "wood spirit" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:1098229 {source="Beilstein"} xref: CAS:67-56-1 {source="KEGG COMPOUND"} xref: CAS:67-56-1 {source="NIST Chemistry WebBook"} xref: CAS:67-56-1 {source="ChemIDplus"} xref: Gmelin:449 {source="Gmelin"} xref: HMDB:HMDB0001875 xref: KEGG:C00132 xref: KEGG:D02309 xref: MetaCyc:METOH xref: PDBeChem:MOH xref: PMID:11141607 {source="Europe PMC"} xref: PMID:11430978 {source="Europe PMC"} xref: PMID:11489599 {source="Europe PMC"} xref: PMID:11680737 {source="Europe PMC"} xref: PMID:11684179 {source="Europe PMC"} xref: PMID:14012711 {source="Europe PMC"} xref: PMID:14678513 {source="Europe PMC"} xref: PMID:14760634 {source="Europe PMC"} xref: PMID:15172721 {source="Europe PMC"} xref: PMID:15906011 {source="Europe PMC"} xref: PMID:16705261 {source="Europe PMC"} xref: PMID:17451998 {source="Europe PMC"} xref: PMID:17733096 {source="Europe PMC"} xref: PMID:19064074 {source="Europe PMC"} xref: PMID:19850112 {source="Europe PMC"} xref: PMID:20314698 {source="Europe PMC"} xref: Reaxys:1098229 {source="Reaxys"} xref: UM-BBD_compID:c0132 {source="UM-BBD"} xref: Wikipedia:Methanol is_a: CHEBI:134179 ! volatile organic compound is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:50584 ! alkyl alcohol is_a: CHEBI:64708 ! one-carbon compound relationship: is_conjugate_acid_of CHEBI:52090 ! methoxide relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite relationship: RO:0000087 CHEBI:33292 ! has role fuel relationship: RO:0000087 CHEBI:48360 ! has role amphiprotic solvent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4O/c1-2/h2H,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OKKJLVBELUTLKV-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "32.04186" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.02621" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO" xsd:string [Term] id: CHEBI:17792 name: organohalogen compound namespace: chebi_ontology alt_id: CHEBI:13444 alt_id: CHEBI:36684 alt_id: CHEBI:8767 def: "A compound containing at least one carbon-halogen bond (where X is a halogen atom)." [] subset: 3_STAR synonym: "organic halide" RELATED [KEGG_COMPOUND] synonym: "organic halides" RELATED [ChEBI] synonym: "organohalogen compounds" RELATED [ChEBI] synonym: "RX" RELATED [UniProt] synonym: "RX" RELATED [KEGG_COMPOUND] xref: KEGG:C01322 xref: MetaCyc:Organohalogen-Compounds is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:37578 ! halide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "RX" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "**" xsd:string [Term] id: CHEBI:17822 name: serine namespace: chebi_ontology alt_id: CHEBI:15081 alt_id: CHEBI:26648 alt_id: CHEBI:9116 def: "An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group." [] subset: 3_STAR synonym: "2-amino-3-hydroxypropanoic acid" RELATED [IUPAC] synonym: "2-Amino-3-hydroxypropionic acid" RELATED [KEGG_COMPOUND] synonym: "3-Hydroxyalanine" RELATED [KEGG_COMPOUND] synonym: "Serin" RELATED [ChEBI] synonym: "Serine" EXACT [KEGG_COMPOUND] synonym: "serine" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:1721402 {source="Beilstein"} xref: CAS:302-84-1 {source="NIST Chemistry WebBook"} xref: CAS:302-84-1 {source="ChemIDplus"} xref: CAS:302-84-1 {source="KEGG COMPOUND"} xref: Gmelin:26429 {source="Gmelin"} xref: KEGG:C00716 xref: KNApSAcK:C00001393 xref: Reaxys:1721402 {source="Reaxys"} xref: Wikipedia:Serine is_a: CHEBI:26167 ! polar amino acid is_a: CHEBI:33704 ! alpha-amino acid relationship: has_part CHEBI:24712 ! hydroxymethyl group relationship: is_conjugate_acid_of CHEBI:32845 ! serinate relationship: is_conjugate_base_of CHEBI:32846 ! serinium relationship: is_tautomer_of CHEBI:35243 ! serine zwitterion relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "105.09262" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "105.04259" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CO)C(O)=O" xsd:string [Term] id: CHEBI:17833 name: gentamycin namespace: chebi_ontology alt_id: CHEBI:14293 alt_id: CHEBI:24206 alt_id: CHEBI:24212 alt_id: CHEBI:5306 def: "Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp." [] subset: 3_STAR synonym: "4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)pentopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)heptopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "Gentamicin" RELATED [KEGG_COMPOUND] synonym: "gentamycins" RELATED [ChEBI] xref: CAS:1403-66-3 {source="KEGG COMPOUND"} xref: DrugBank:DB00798 xref: KEGG:C00505 is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:17883 name: hydrogen chloride namespace: chebi_ontology alt_id: CHEBI:13364 alt_id: CHEBI:24635 alt_id: CHEBI:5590 def: "A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms." [] subset: 3_STAR synonym: "[HCl]" RELATED [IUPAC] synonym: "chlorane" EXACT IUPAC_NAME [IUPAC] synonym: "chloridohydrogen" EXACT IUPAC_NAME [IUPAC] synonym: "chlorure d'hydrogene" RELATED [ChEBI] synonym: "Chlorwasserstoff" RELATED [ChEBI] synonym: "cloruro de hidrogeno" RELATED [ChEBI] synonym: "HCl" RELATED [KEGG_COMPOUND] synonym: "hydrochloric acid" RELATED [ChemIDplus] synonym: "Hydrochloride" RELATED [KEGG_COMPOUND] synonym: "Hydrogen chloride" EXACT [KEGG_COMPOUND] synonym: "hydrogen chloride" EXACT IUPAC_NAME [IUPAC] synonym: "Hydrogenchlorid" RELATED [ChEBI] synonym: "Wasserstoffchlorid" RELATED [ChEBI] xref: CAS:7647-01-0 {source="ChemIDplus"} xref: CAS:7647-01-0 {source="NIST Chemistry WebBook"} xref: CAS:7647-01-0 {source="KEGG COMPOUND"} xref: Drug_Central:4568 {source="DrugCentral"} xref: Gmelin:322 {source="Gmelin"} xref: HMDB:HMDB0002306 xref: KEGG:C01327 xref: KEGG:D02057 xref: MetaCyc:HCL xref: PMID:15823700 {source="Europe PMC"} xref: PMID:17492841 {source="Europe PMC"} xref: PMID:22804993 {source="Europe PMC"} xref: Reaxys:1098214 {source="Reaxys"} xref: Wikipedia:HCl xref: Wikipedia:Hydrochloric_acid is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:18140 ! hydrogen halide is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:37176 ! mononuclear parent hydride relationship: is_conjugate_acid_of CHEBI:17996 ! chloride relationship: is_conjugate_base_of CHEBI:50315 ! chloronium relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "ClH" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HCl" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH/h1H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VEXZGXHMUGYJMC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "36.46064" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "35.97668" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cl[H]" xsd:string [Term] id: CHEBI:17891 name: donor namespace: chebi_ontology alt_id: CHEBI:14202 alt_id: CHEBI:4697 def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." [] subset: 3_STAR synonym: "Donator" RELATED [ChEBI] synonym: "donneur" RELATED [ChEBI] synonym: "Donor" EXACT [KEGG_COMPOUND] xref: KEGG:C01351 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:17925 name: alpha-D-glucose namespace: chebi_ontology alt_id: CHEBI:10242 alt_id: CHEBI:12318 alt_id: CHEBI:22386 alt_id: CHEBI:40557 alt_id: CHEBI:42802 def: "D-Glucopyranose having alpha-configuration at the anomeric centre." [] subset: 3_STAR synonym: "alpha-D-Glc" RELATED [ChEBI] synonym: "alpha-D-glucopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "ALPHA-D-GLUCOSE" EXACT [PDBeChem] synonym: "alpha-D-Glucose" EXACT [KEGG_COMPOUND] synonym: "alpha-D-glucose" EXACT [UniProt] synonym: "alpha-dextrose" RELATED [ChemIDplus] synonym: "WURCS=2.0/1,1,0/[a2122h-1a_1-5]/1/" RELATED [GlyTouCan] xref: Beilstein:1281608 {source="Beilstein"} xref: Beilstein:5730158 {source="Beilstein"} xref: CAS:492-62-6 {source="KEGG COMPOUND"} xref: CAS:492-62-6 {source="NIST Chemistry WebBook"} xref: CAS:492-62-6 {source="ChemIDplus"} xref: GlyGen:G58161NS xref: GlyTouCan:G58161NS xref: Gmelin:329225 {source="Gmelin"} xref: KEGG:C00267 xref: KNApSAcK:C00001122 xref: PDBeChem:GLC xref: PMID:19443021 {source="Europe PMC"} xref: PMID:25568069 {source="Europe PMC"} xref: PMID:31537530 {source="Europe PMC"} is_a: CHEBI:4167 ! D-glucopyranose relationship: is_enantiomer_of CHEBI:37630 ! alpha-L-glucose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-DVKNGEFBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:17996 name: chloride namespace: chebi_ontology alt_id: CHEBI:13291 alt_id: CHEBI:13970 alt_id: CHEBI:3616 alt_id: CHEBI:3731 alt_id: CHEBI:48804 def: "A halide anion formed when chlorine picks up an electron to form an an anion." [] subset: 3_STAR synonym: "Chloride" EXACT [KEGG_COMPOUND] synonym: "chloride" EXACT [UniProt] synonym: "chloride" EXACT IUPAC_NAME [IUPAC] synonym: "CHLORIDE ION" RELATED [PDBeChem] synonym: "Chloride ion" RELATED [KEGG_COMPOUND] synonym: "Chloride(1-)" RELATED [ChemIDplus] synonym: "chloride(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "Chlorine anion" RELATED [NIST_Chemistry_WebBook] synonym: "Cl(-)" RELATED [IUPAC] synonym: "Cl-" RELATED [KEGG_COMPOUND] xref: Beilstein:3587171 {source="Beilstein"} xref: CAS:16887-00-6 {source="ChemIDplus"} xref: CAS:16887-00-6 {source="NIST Chemistry WebBook"} xref: CAS:16887-00-6 {source="KEGG COMPOUND"} xref: Gmelin:14910 {source="Gmelin"} xref: KEGG:C00115 xref: KEGG:C00698 xref: PDBeChem:CL xref: UM-BBD_compID:c0884 {source="UM-BBD"} is_a: CHEBI:16042 ! halide anion is_a: CHEBI:33432 ! monoatomic chlorine relationship: is_conjugate_base_of CHEBI:17883 ! hydrogen chloride relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH/h1H/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VEXZGXHMUGYJMC-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "35.45270" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96940" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cl-]" xsd:string [Term] id: CHEBI:18059 name: lipid namespace: chebi_ontology alt_id: CHEBI:14517 alt_id: CHEBI:25054 alt_id: CHEBI:6486 def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." [] subset: 3_STAR synonym: "Lipid" EXACT [KEGG_COMPOUND] synonym: "lipids" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C01356 is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:18133 name: hexose namespace: chebi_ontology alt_id: CHEBI:14399 alt_id: CHEBI:24590 alt_id: CHEBI:5709 def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." [] subset: 3_STAR synonym: "Hexose" EXACT [KEGG_COMPOUND] synonym: "hexoses" RELATED [ChEBI] synonym: "WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/" RELATED [GlyTouCan] xref: GlyGen:G70994MS xref: GlyTouCan:G70994MS xref: KEGG:C00738 is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:18140 name: hydrogen halide namespace: chebi_ontology alt_id: CHEBI:13368 alt_id: CHEBI:37140 alt_id: CHEBI:5599 subset: 3_STAR synonym: "hydrogen halide" EXACT [IUPAC] synonym: "hydrogen halides" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen halides" RELATED [ChEBI] is_a: CHEBI:33405 ! hydracid relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HX" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1.008" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.00783" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*[H]" xsd:string [Term] id: CHEBI:18154 name: polysaccharide namespace: chebi_ontology alt_id: CHEBI:14864 alt_id: CHEBI:26205 alt_id: CHEBI:8322 def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." [] subset: 3_STAR synonym: "Glycan" RELATED [KEGG_COMPOUND] synonym: "Glycane" RELATED [ChEBI] synonym: "glycans" RELATED [IUPAC] synonym: "Glykan" RELATED [ChEBI] synonym: "Glykane" RELATED [ChEBI] synonym: "polisacarido" RELATED [ChEBI] synonym: "polisacaridos" RELATED [IUPAC] synonym: "Polysaccharide" EXACT [KEGG_COMPOUND] synonym: "polysaccharides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00420 is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:18208 name: benzylpenicillin namespace: chebi_ontology alt_id: CHEBI:14743 alt_id: CHEBI:25866 alt_id: CHEBI:45073 alt_id: CHEBI:7962 def: "A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [ChEBI] synonym: "2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "6-(2-phenylacetamido)penicillanic acid" RELATED [ChemIDplus] synonym: "bencilpenicilina" RELATED INN [ChemIDplus] synonym: "bensylpenicillin" RELATED [ChEBI] synonym: "benzyl benicillin" RELATED [ChEBI] synonym: "Benzylpenicillin" EXACT [KEGG_COMPOUND] synonym: "benzylpenicillin" RELATED INN [KEGG_DRUG] synonym: "benzylpenicilline" RELATED INN [ChemIDplus] synonym: "benzylpenicillinic acid" RELATED [ChemIDplus] synonym: "benzylpenicillinum" RELATED INN [ChemIDplus] synonym: "free penicillin II" RELATED [ChemIDplus] synonym: "PCG" RELATED [ChEBI] synonym: "PENICILLIN G" RELATED [PDBeChem] synonym: "Penicillin G" RELATED [KEGG_COMPOUND] synonym: "PG" RELATED [ChEBI] xref: Beilstein:44740 {source="Beilstein"} xref: CAS:61-33-6 {source="ChemIDplus"} xref: CAS:61-33-6 {source="KEGG COMPOUND"} xref: Drug_Central:2082 {source="DrugCentral"} xref: DrugBank:DB01053 xref: Gmelin:781913 {source="Gmelin"} xref: HMDB:HMDB0015186 xref: KEGG:C05551 xref: KEGG:D02336 xref: LINCS:LSM-3229 xref: Patent:US3024169 xref: PDBeChem:PNN xref: PMID:10930630 {source="Europe PMC"} xref: PMID:11431418 {source="Europe PMC"} xref: PMID:11906332 {source="Europe PMC"} xref: PMID:12569987 {source="Europe PMC"} xref: PMID:12850488 {source="Europe PMC"} xref: PMID:1384868 {source="Europe PMC"} xref: PMID:16033609 {source="Europe PMC"} xref: PMID:1709917 {source="Europe PMC"} xref: PMID:2083978 {source="Europe PMC"} xref: PMID:24485692 {source="Europe PMC"} xref: PMID:24631718 {source="Europe PMC"} xref: PMID:25998949 {source="Europe PMC"} xref: PMID:27731424 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:29355985 {source="Europe PMC"} xref: PMID:6161899 {source="Europe PMC"} xref: PMID:7602118 {source="Europe PMC"} xref: PMID:7716788 {source="Europe PMC"} xref: Reaxys:44740 {source="Reaxys"} xref: Wikipedia:Benzylpenicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51354 ! benzylpenicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:53000 ! has role epitope relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H18N2O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JGSARLDLIJGVTE-MBNYWOFBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "334.392" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "334.09873" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N12C([C@H]([C@]1(SC([C@@H]2C(O)=O)(C)C)[H])NC(CC3=CC=CC=C3)=O)=O" xsd:string [Term] id: CHEBI:18254 name: ribonucleoside namespace: chebi_ontology alt_id: CHEBI:13014 alt_id: CHEBI:13015 alt_id: CHEBI:13685 alt_id: CHEBI:21085 alt_id: CHEBI:26560 alt_id: CHEBI:4240 alt_id: CHEBI:8844 def: "Any nucleoside where the sugar component is D-ribose." [] subset: 3_STAR synonym: "a ribonucleoside" RELATED [UniProt] synonym: "Ribonucleoside" EXACT [KEGG_COMPOUND] synonym: "ribonucleosides" RELATED [ChEBI] xref: KEGG:C00911 is_a: CHEBI:33838 ! nucleoside is_a: CHEBI:47019 ! dihydroxytetrahydrofuran property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O4R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "133.123" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "133.05008" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:18257 name: ornithine namespace: chebi_ontology alt_id: CHEBI:7784 def: "An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5." [] subset: 3_STAR synonym: "2,5-Diaminopentanoic acid" RELATED [KEGG_COMPOUND] synonym: "2,5-diaminopentanoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "2,5-Diaminovaleric acid" RELATED [KEGG_COMPOUND] synonym: "DL-Ornithine" RELATED [ChemIDplus] synonym: "Orn" RELATED [IUPAC] synonym: "Ornithine" EXACT [KEGG_COMPOUND] synonym: "ornithine" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:1722296 {source="Beilstein"} xref: CAS:616-07-9 {source="ChemIDplus"} xref: Gmelin:847696 {source="Gmelin"} xref: KEGG:C01602 xref: KNApSAcK:C00001384 xref: PMID:15449570 {source="Europe PMC"} xref: PMID:17190852 {source="Europe PMC"} xref: PMID:22264337 {source="Europe PMC"} xref: Reaxys:1722296 {source="Reaxys"} is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid relationship: is_conjugate_acid_of CHEBI:32964 ! ornithinate relationship: is_conjugate_base_of CHEBI:46912 ! ornithinium(1+) relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H12N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "132.16106" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "132.08988" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCCC(N)C(O)=O" xsd:string [Term] id: CHEBI:18282 name: nucleobase namespace: chebi_ontology alt_id: CHEBI:13873 alt_id: CHEBI:25598 alt_id: CHEBI:2995 def: "That part of DNA or RNA that may be involved in pairing." [] subset: 3_STAR synonym: "Base" RELATED [KEGG_COMPOUND] synonym: "nucleobases" RELATED [ChEBI] xref: KEGG:C00701 xref: Wikipedia:Nucleobase is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:18291 name: manganese atom namespace: chebi_ontology alt_id: CHEBI:13382 alt_id: CHEBI:25153 alt_id: CHEBI:6681 subset: 3_STAR synonym: "25Mn" RELATED [IUPAC] synonym: "Mangan" RELATED [NIST_Chemistry_WebBook] synonym: "Manganese" RELATED [KEGG_COMPOUND] synonym: "manganese" EXACT IUPAC_NAME [IUPAC] synonym: "manganese" RELATED [ChEBI] synonym: "manganeso" RELATED [ChEBI] synonym: "manganum" RELATED [ChEBI] synonym: "Mn" RELATED [IUPAC] synonym: "Mn" RELATED [UniProt] xref: CAS:7439-96-5 {source="KEGG COMPOUND"} xref: CAS:7439-96-5 {source="ChemIDplus"} xref: KEGG:C00034 xref: WebElements:Mn is_a: CHEBI:33352 ! manganese group element atom relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Mn" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Mn" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PWHULOQIROXLJO-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "54.93805" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "54.93804" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Mn]" xsd:string [Term] id: CHEBI:18310 name: alkane namespace: chebi_ontology alt_id: CHEBI:13435 alt_id: CHEBI:22317 alt_id: CHEBI:2576 def: "An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms." [] subset: 3_STAR synonym: "alcane" RELATED [IUPAC] synonym: "alcanes" RELATED [IUPAC] synonym: "alcano" RELATED [IUPAC] synonym: "alcanos" RELATED [IUPAC] synonym: "Alkan" RELATED [ChEBI] synonym: "Alkane" EXACT [KEGG_COMPOUND] synonym: "alkane" EXACT IUPAC_NAME [IUPAC] synonym: "alkanes" EXACT IUPAC_NAME [IUPAC] synonym: "an alkane" RELATED [UniProt] synonym: "RH" RELATED [KEGG_COMPOUND] xref: KEGG:C01371 is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:33653 ! aliphatic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "15.035" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.02348" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[*]" xsd:string [Term] id: CHEBI:18320 name: 1,4-dithiothreitol namespace: chebi_ontology alt_id: CHEBI:11174 alt_id: CHEBI:23854 alt_id: CHEBI:4664 def: "The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol." [] subset: 3_STAR synonym: "(R*,R*)-1,4-dimercapto-2,3-butanediol" RELATED [NIST_Chemistry_WebBook] synonym: "1,4-Dithiothreitol" EXACT [KEGG_COMPOUND] synonym: "1,4-dithiothreitol" EXACT [UniProt] synonym: "Cleland's reagent" RELATED [NIST_Chemistry_WebBook] synonym: "Dithiothreitol" RELATED [KEGG_COMPOUND] synonym: "Dithiotreitol" RELATED [ChemIDplus] synonym: "DL-threo-1,4-Dimercapto-2,3-butanediol" RELATED [ChemIDplus] synonym: "DTL" RELATED [ChEBI] synonym: "DTT" RELATED [ChEBI] synonym: "rac-Dithiothreitol" RELATED [ChemIDplus] synonym: "rel-(2R,3R)-1,4-disulfanylbutane-2,3-diol" EXACT IUPAC_NAME [IUPAC] synonym: "threo-1,4-Dimercapto-2,3-butanediol" RELATED [KEGG_COMPOUND] xref: Beilstein:8144556 {source="Beilstein"} xref: CAS:3483-12-3 {source="ChemIDplus"} xref: CAS:3483-12-3 {source="NIST Chemistry WebBook"} xref: CAS:3483-12-3 {source="KEGG COMPOUND"} xref: DrugBank:DB04447 xref: KEGG:C00265 xref: LINCS:LSM-36870 xref: PMID:16901854 {source="Europe PMC"} xref: PMID:18022205 {source="Europe PMC"} xref: PMID:23673948 {source="Europe PMC"} xref: PMID:24124079 {source="Europe PMC"} xref: PMID:7592847 {source="Europe PMC"} is_a: CHEBI:23853 ! dithiol is_a: CHEBI:25189 ! 1,4-dimercaptobutane-2,3-diol relationship: RO:0000087 CHEBI:38161 ! has role chelator relationship: RO:0000087 CHEBI:63247 ! has role reducing agent relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H10O2S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VHJLVAABSRFDPM-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "154.25100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "154.01222" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(CS)C(O)CS" xsd:string [Term] id: CHEBI:18367 name: phosphate(3-) namespace: chebi_ontology alt_id: CHEBI:14791 alt_id: CHEBI:45024 alt_id: CHEBI:7793 def: "A phosphate ion that is the conjugate base of hydrogenphosphate." [] subset: 3_STAR synonym: "[PO4](3-)" RELATED [IUPAC] synonym: "Orthophosphate" RELATED [KEGG_COMPOUND] synonym: "Phosphate" RELATED [KEGG_COMPOUND] synonym: "phosphate" EXACT IUPAC_NAME [IUPAC] synonym: "PHOSPHATE ION" RELATED [PDBeChem] synonym: "PO4(3-)" RELATED [IUPAC] synonym: "tetraoxidophosphate(3-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxophosphate(3-)" EXACT IUPAC_NAME [IUPAC] synonym: "tetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3903772 {source="Beilstein"} xref: CAS:14265-44-2 {source="KEGG COMPOUND"} xref: CAS:14265-44-2 {source="ChemIDplus"} xref: Gmelin:1997 {source="Gmelin"} xref: KEGG:C00009 xref: PDBeChem:PO4 {source="ChEBI"} xref: Reaxys:3903772 {source="Reaxys"} is_a: CHEBI:35780 ! phosphate ion is_a: CHEBI:79387 ! trivalent inorganic anion relationship: is_conjugate_base_of CHEBI:43474 ! hydrogenphosphate property_value: http://purl.obolibrary.org/obo/chebi/charge "-3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-K" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "94.97136" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "94.95507" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]P([O-])([O-])=O" xsd:string [Term] id: CHEBI:18375 name: nucleoside 3',5'-cyclic phosphate namespace: chebi_ontology alt_id: CHEBI:1331 alt_id: CHEBI:14672 alt_id: CHEBI:19833 def: "A ribosyl or deoxyribosyl derivative of a pyrimidine or purine base in which C-3 and C-5 of the ribose ring are engaged in formation of a cyclic mono-, di-, tri- or tetra-phosphate." [] subset: 3_STAR synonym: "nucleoside 3',5'-cyclic phosphates" RELATED [ChEBI] is_a: CHEBI:23447 ! cyclic nucleotide relationship: is_conjugate_acid_of CHEBI:58464 ! nucleoside 3',5'-cyclic phosphate anion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H7O5PR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "178.07980" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "178.00311" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OP1(=O)OC[C@H]2O[C@@H]([*])[C@H]([*])[C@@H]2O1" xsd:string [Term] id: CHEBI:18379 name: nitrile namespace: chebi_ontology alt_id: CHEBI:13212 alt_id: CHEBI:13426 alt_id: CHEBI:13660 alt_id: CHEBI:25547 alt_id: CHEBI:7584 def: "A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it." [] subset: 3_STAR synonym: "a nitrile" RELATED [UniProt] synonym: "Nitril" RELATED [ChEBI] synonym: "Nitrile" EXACT [KEGG_COMPOUND] synonym: "nitrile" EXACT [IUPAC] synonym: "nitriles" EXACT IUPAC_NAME [IUPAC] synonym: "nitrilos" RELATED [IUPAC] synonym: "R-CN" RELATED [KEGG_COMPOUND] xref: KEGG:C00726 is_a: CHEBI:23424 ! cyanides relationship: has_part CHEBI:48819 ! cyano group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "26.01740" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "26.00307" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C#N" xsd:string [Term] id: CHEBI:18407 name: hydrogen cyanide namespace: chebi_ontology alt_id: CHEBI:13362 alt_id: CHEBI:5786 def: "A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom" [] subset: 3_STAR synonym: "[CHN]" RELATED [IUPAC] synonym: "Blausaeure" RELATED [ChEBI] synonym: "Cyanwasserstoff" RELATED [NIST_Chemistry_WebBook] synonym: "formonitrile" RELATED [IUPAC] synonym: "HCN" RELATED [KEGG_COMPOUND] synonym: "hydridonitridocarbon" EXACT IUPAC_NAME [IUPAC] synonym: "hydrocyanic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Hydrogen cyanide" EXACT [KEGG_COMPOUND] synonym: "hydrogen cyanide" EXACT [IUPAC] synonym: "hydrogen cyanide" EXACT [UniProt] synonym: "hydrogen(nitridocarbonate)" EXACT IUPAC_NAME [IUPAC] synonym: "methanenitrile" EXACT IUPAC_NAME [IUPAC] xref: CAS:74-90-8 {source="ChemIDplus"} xref: CAS:74-90-8 {source="NIST Chemistry WebBook"} xref: CAS:74-90-8 {source="KEGG COMPOUND"} xref: HMDB:HMDB0060292 xref: KEGG:C01326 xref: KNApSAcK:C00007569 xref: MetaCyc:HCN xref: PMID:19849830 {source="Europe PMC"} xref: PMID:26700190 {source="Europe PMC"} xref: PMID:26778429 {source="Europe PMC"} xref: PMID:26823582 {source="Europe PMC"} xref: PMID:26940198 {source="Europe PMC"} xref: PMID:27123778 {source="Europe PMC"} xref: Reaxys:1718793 {source="Reaxys"} xref: Wikipedia:Hydrogen_cyanide is_a: CHEBI:33405 ! hydracid is_a: CHEBI:64708 ! one-carbon compound relationship: is_conjugate_acid_of CHEBI:17514 ! cyanide relationship: is_tautomer_of CHEBI:36856 ! hydrogen isocyanide relationship: RO:0000087 CHEBI:64909 ! has role poison relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHN" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CHN/c1-2/h1H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LELOWRISYMNNSU-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "27.02530" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.01090" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C#N" xsd:string [Term] id: CHEBI:184376 name: streptidine(2+) namespace: chebi_ontology def: "A guanidinium ion obtained by protonation of both guanidino groups of streptidine; major species at pH 7.3." [] subset: 3_STAR synonym: "streptidine" RELATED [UniProt] synonym: "streptidine dication" RELATED [ChEBI] synonym: "{[(1R,2s,3S,4R,5r,6S)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diazanediyl}bis(aminomethaniminium)" RELATED [IUPAC] synonym: "{[(1R,2s,3S,4R,5r,6S)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diimino}bis(aminomethaniminium)" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:60251 ! guanidinium ion relationship: is_conjugate_acid_of CHEBI:27405 ! streptidine property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H20N6O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H18N6O4/c9-7(10)13-1-3(15)2(14-8(11)12)5(17)6(18)4(1)16/h1-6,15-18H,(H4,9,10,13)(H4,11,12,14)/p+2/t1-,2+,3-,4+,5-,6-" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MSXMXWJPFIDEMT-FAEUDGQSSA-P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "264.285" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "264.15351" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=[NH2+])N[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](NC(N)=[NH2+])[C@@H]1O" xsd:string [Term] id: CHEBI:184381 name: bacitracin A zwitterion namespace: chebi_ontology subset: 2_STAR synonym: "bacitracin A" RELATED [UniProt] xref: MetaCyc:CPD-19353 {source="SUBMITTER"} is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:28669 ! bacitracin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C66H103N17O16S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CLKOFPXJLQSYAH-ABRJDSQDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1422.710" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1421.74894" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H]1(C(N[C@H](CC=2C=CC=CC2)C(=O)N[C@H](C(N[C@@H](C(N[C@H](C(NCCCC[C@@H](C(N[C@@H](C(N1)=O)CCC[NH3+])=O)NC([C@@H](NC([C@H](NC([C@@H](NC([C@H]3N=C(SC3)[C@H]([C@H](CC)C)[NH3+])=O)CC(C)C)=O)CCC([O-])=O)=O)[C@@H](C)CC)=O)=O)CC(N)=O)=O)CC(=O)[O-])=O)CC4=CNC=N4)=O)[C@@H](C)CC" xsd:string [Term] id: CHEBI:18946 name: delta-lactone namespace: chebi_ontology def: "A lactone having a six-membered lactone ring." [] subset: 3_STAR synonym: "1,5-lactone" RELATED [ChEBI] synonym: "1,5-lactones" RELATED [ChEBI] synonym: "delta-lactona" RELATED [ChEBI] synonym: "delta-lactonas" RELATED [ChEBI] synonym: "delta-lactone" EXACT [ChEBI] synonym: "delta-lactones" RELATED [ChEBI] is_a: CHEBI:25000 ! lactone [Term] id: CHEBI:190303 name: inorganic potassium salt namespace: chebi_ontology def: "A potassium salt that lacks C-H bonds" [] subset: 2_STAR is_a: CHEBI:167164 ! mineral nutrient is_a: CHEBI:24839 ! inorganic salt is_a: CHEBI:26218 ! potassium salt [Term] id: CHEBI:190509 name: imipenem zwitterion namespace: chebi_ontology def: "Zwitterionic form of imipenem having an anionic carboxy group and a protonated methaneimidamido group; major species at pH 7.3." [] subset: 3_STAR synonym: "(5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminiomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "imipenem" RELATED [UniProt] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:471744 ! imipenem property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H17N3O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H17N3O4S/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/t6-,7-,9-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZSKVGTPCRGIANV-ZXFLCMHBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "299.350" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "299.09398" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=[NH2+])NCCSC1=C(N2C(=O)[C@]([H])([C@@H](C)O)[C@@]2([H])C1)C([O-])=O" xsd:string [Term] id: CHEBI:19129 name: 11alpha-hydroxy steroid namespace: chebi_ontology subset: 3_STAR synonym: "11alpha-hydroxy steroids" RELATED [ChEBI] is_a: CHEBI:36841 ! 11-hydroxy steroid [Term] id: CHEBI:192484 name: ciprofloxacin zwitterion namespace: chebi_ontology def: "A zwitterion formed from ciprofloxacin by transfer of a proton from the carboxy to the amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: MetaCyc:CPD-12843 xref: PMID:11202360 {source="SUBMITTER"} xref: PMID:12084502 {source="SUBMITTER"} xref: PMID:21368411 {source="Europe PMC"} xref: PMID:9303400 {source="SUBMITTER"} is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:100241 ! ciprofloxacin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H18FN3O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYSWGUAQZAJSOK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "331.347" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "331.13322" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)C1=CN(C2CC2)C2=CC(N3CC[NH2+]CC3)=C(F)C=C2C1=O" xsd:string [Term] id: CHEBI:192486 name: ciprofloxacin(1+) namespace: chebi_ontology def: "A secondary ammonium ion that is the conjugate acid of ciprofloxacin resulting from the protonation of the NH group; major species at acidic pH." [] subset: 3_STAR synonym: "4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazin-1-ium" EXACT IUPAC_NAME [IUPAC] synonym: "ciprofloxacin cation" RELATED [ChEBI] xref: PMID:35371545 {source="Europe PMC"} is_a: CHEBI:137419 ! secondary ammonium ion relationship: is_conjugate_acid_of CHEBI:100241 ! ciprofloxacin property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H19FN3O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)/p+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYSWGUAQZAJSOK-UHFFFAOYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "332.355" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "332.14050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)C1=CN(C2CC2)C2=CC(N3CC[NH2+]CC3)=C(F)C=C2C1=O" xsd:string [Term] id: CHEBI:192979 name: nystatin A2 namespace: chebi_ontology subset: 3_STAR synonym: "(1R,3S,7R,9R,11R,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,7,9,11,17,37-heptahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "nystatin A2" EXACT [ChemIDplus] xref: CAS:65086-32-0 {source="ChemIDplus"} xref: PMID:15504830 {source="Europe PMC"} is_a: CHEBI:59676 ! nystatins property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C47H75NO16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C47H75NO16/c1-28-18-15-13-11-9-7-5-6-8-10-12-14-16-21-36(63-46-44(57)41(48)43(56)31(4)62-46)25-38-40(45(58)59)37(53)27-47(60,64-38)26-33(50)20-17-19-32(49)22-34(51)23-35(52)24-39(54)61-30(3)29(2)42(28)55/h5-6,8,10-16,18,21,28-38,40-44,46,49-53,55-57,60H,7,9,17,19-20,22-27,48H2,1-4H3,(H,58,59)/b6-5+,10-8+,13-11+,14-12+,18-15+,21-16+/t28-,29-,30-,31+,32+,33-,34+,35+,36-,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RALQCAVZSAUESR-XTEMEEEFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "910.108" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "909.50859" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\CC\\C=C\\C=C\\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CCC[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2" xsd:string [Term] id: CHEBI:194135 name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid namespace: chebi_ontology def: "An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively." [] subset: 3_STAR synonym: "9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:46920 ! N-methylpiperazine is_a: CHEBI:47881 ! 3-oxo monocarboxylic acid is_a: CHEBI:53665 ! oxazinoquinoline property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H20FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GSDSWSVVBLHKDQ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "361.373" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "361.14378" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1COC2=C(N3CCN(C)CC3)C(F)=CC3=C2N1C=C(C(O)=O)C3=O" xsd:string [Term] id: CHEBI:19834 name: 3',5'-cyclic purine nucleotide namespace: chebi_ontology subset: 3_STAR synonym: "3',5'-cyclic purine nucleotides" RELATED [ChEBI] is_a: CHEBI:18375 ! nucleoside 3',5'-cyclic phosphate is_a: CHEBI:36982 ! cyclic purine nucleotide [Term] id: CHEBI:204928 name: cefotaxime namespace: chebi_ontology alt_id: CHEBI:112504 alt_id: CHEBI:3497 alt_id: CHEBI:41475 def: "A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups." [] subset: 3_STAR synonym: "(6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "(6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "(6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "3-(acetoxymethyl)-7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "cefotaxima" RELATED INN [ChemIDplus] synonym: "cefotaxime" RELATED INN [KEGG_DRUG] synonym: "cefotaximum" RELATED INN [ChemIDplus] synonym: "Cephotaxime" RELATED [ChemIDplus] xref: Beilstein:1096643 {source="Beilstein"} xref: CAS:63527-52-6 {source="ChemIDplus"} xref: CAS:63527-52-6 {source="KEGG DRUG"} xref: CAS:63527-52-6 {source="KEGG COMPOUND"} xref: CAS:63527-52-6 {source="DrugBank"} xref: Drug_Central:546 {source="DrugCentral"} xref: DrugBank:DB00493 xref: KEGG:C06885 xref: KEGG:D07647 xref: Patent:DE2556736 xref: Patent:DE2702501 xref: Patent:US4098888 xref: Patent:US4152432 xref: PDBeChem:CE3 xref: PMID:10866367 {source="ChEMBL"} xref: PMID:11034276 {source="Europe PMC"} xref: PMID:11061623 {source="Europe PMC"} xref: PMID:11677129 {source="ChEMBL"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:1384868 {source="Europe PMC"} xref: PMID:14512220 {source="Europe PMC"} xref: PMID:1502708 {source="Europe PMC"} xref: PMID:15164972 {source="Europe PMC"} xref: PMID:15361989 {source="Europe PMC"} xref: PMID:15969234 {source="Europe PMC"} xref: PMID:1635063 {source="ChEMBL"} xref: PMID:17006042 {source="Europe PMC"} xref: PMID:17386217 {source="Europe PMC"} xref: PMID:18611527 {source="Europe PMC"} xref: PMID:19741292 {source="Europe PMC"} xref: PMID:21425867 {source="Europe PMC"} xref: PMID:24038683 {source="Europe PMC"} xref: PMID:24211456 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:9131470 {source="Europe PMC"} xref: Reaxys:1096643 {source="Reaxys"} xref: Wikipedia:Cefotaxime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether is_a: CHEBI:38418 ! 1,3-thiazoles relationship: is_conjugate_acid_of CHEBI:53670 ! cefotaxime(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H17N5O7S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GPRBEKHLDVQUJE-QSWIMTSFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "455.46500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "455.05694" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O" xsd:string [Term] id: CHEBI:20854 name: ATP synthase inhibitor namespace: chebi_ontology def: "A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase." [] subset: 3_STAR is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:73216 ! EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor [Term] id: CHEBI:209807 name: cefoxitin namespace: chebi_ontology alt_id: CHEBI:3500 alt_id: CHEBI:41436 alt_id: CHEBI:471714 alt_id: CHEBI:658070 def: "A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase." [] subset: 3_STAR synonym: "(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "(6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "3-[(carbamoyloxy)methyl]-7alpha-methoxy-7beta-[(thiophen-2-yl)acetamido]-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Cefoxitin" EXACT [ChemIDplus] synonym: "cefoxitin" RELATED INN [KEGG_DRUG] synonym: "cefoxitina" RELATED INN [ChemIDplus] synonym: "cefoxitine" RELATED INN [ChemIDplus] synonym: "cefoxitinum" RELATED INN [ChemIDplus] synonym: "ceftoxitin" RELATED INN [ChemIDplus] synonym: "Cephoxitin" RELATED [ChemIDplus] synonym: "CFX" RELATED [KEGG_DRUG] synonym: "Rephoxitin" RELATED [ChemIDplus] xref: Beilstein:4216947 {source="Beilstein"} xref: CAS:35607-66-0 {source="ChemIDplus"} xref: CAS:35607-66-0 {source="KEGG COMPOUND"} xref: Drug_Central:550 {source="DrugCentral"} xref: DrugBank:DB01331 xref: HMDB:HMDB0015426 xref: KEGG:C06887 xref: KEGG:D02345 xref: LINCS:LSM-5786 xref: Patent:DE2129675 xref: Patent:DE2203653 xref: Patent:US4297488 xref: PDBeChem:CFX xref: PMID:12569987 {source="Europe PMC"} xref: PMID:17043131 {source="ChEMBL"} xref: PMID:17178800 {source="ChEMBL"} xref: PMID:17220412 {source="ChEMBL"} xref: PMID:17353248 {source="ChEMBL"} xref: PMID:17387156 {source="ChEMBL"} xref: PMID:17923492 {source="ChEMBL"} xref: PMID:18056283 {source="ChEMBL"} xref: PMID:18070972 {source="ChEMBL"} xref: PMID:2083978 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:8360877 {source="ChEMBL"} xref: Reaxys:4216947 {source="Reaxys"} xref: Wikipedia:Cefoxitin is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:55429 ! cephamycin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_conjugate_acid_of CHEBI:53655 ! cefoxitin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H17N3O7S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WZOZEZRFJCJXNZ-ZBFHGGJFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "427.45200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "427.05079" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)Cc1cccs1)OC)C(O)=O" xsd:string [Term] id: CHEBI:21638 name: N-acylglucosamine namespace: chebi_ontology subset: 3_STAR synonym: "N-acylglucosamine" EXACT [ChEBI] synonym: "N-acylglucosamines" RELATED [ChEBI] is_a: CHEBI:21656 ! N-acyl-hexosamine is_a: CHEBI:24271 ! glucosamines [Term] id: CHEBI:21656 name: N-acyl-hexosamine namespace: chebi_ontology subset: 3_STAR synonym: "N-acyl-hexosamine" EXACT [ChEBI] synonym: "N-acyl-hexosamines" RELATED [ChEBI] is_a: CHEBI:24586 ! hexosamine [Term] id: CHEBI:21731 name: N-glycosyl compound namespace: chebi_ontology def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond." [] subset: 3_STAR synonym: "glycosylamine" EXACT IUPAC_NAME [IUPAC] synonym: "glycosylamines" RELATED [IUPAC] synonym: "N-glycoside" RELATED [ChEBI] synonym: "N-glycosides" RELATED [ChEBI] synonym: "N-glycosyl compounds" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:63161 ! glycosyl compound [Term] id: CHEBI:22153 name: acaricide namespace: chebi_ontology def: "A substance used to destroy pests of the subclass Acari (mites and ticks)." [] subset: 3_STAR synonym: "acaricides" RELATED [ChEBI] synonym: "Akarizid" RELATED [ChEBI] synonym: "Akarizide" RELATED [ChEBI] synonym: "miticide" RELATED [ChEBI] xref: Wikipedia:Acaricide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:22160 name: acetamides namespace: chebi_ontology def: "Compounds with the general formula RNHC(=O)CH3." [] subset: 3_STAR is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:22221 name: acyl group namespace: chebi_ontology def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." [] subset: 3_STAR synonym: "acyl group" EXACT [IUPAC] synonym: "acyl groups" RELATED [ChEBI] synonym: "alkanoyl" EXACT IUPAC_NAME [IUPAC] synonym: "alkanoyl group" RELATED [ChEBI] synonym: "groupe acyle" RELATED [IUPAC] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:22314 name: alkali metal atom namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal" RELATED [ChEBI] synonym: "alkali metals" EXACT IUPAC_NAME [IUPAC] synonym: "Alkalimetall" RELATED [ChEBI] synonym: "Alkalimetalle" RELATED [ChEBI] synonym: "metal alcalin" RELATED [ChEBI] synonym: "metal alcalino" RELATED [ChEBI] synonym: "metales alcalinos" RELATED [ChEBI] synonym: "metaux alcalins" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom is_a: CHEBI:33521 ! metal atom is_a: CHEBI:33559 ! s-block element atom [Term] id: CHEBI:22315 name: alkaloid namespace: chebi_ontology def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." [] subset: 3_STAR synonym: "alcaloide" RELATED [ChEBI] synonym: "alcaloides" RELATED [ChEBI] synonym: "Alkaloid" EXACT [ChEBI] synonym: "Alkaloide" RELATED [ChEBI] synonym: "alkaloids" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Alkaloid is_a: CHEBI:35352 ! organonitrogen compound relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:22323 name: alkyl group namespace: chebi_ontology def: "A univalent group -CnH2n+1 derived from an alkane by removal of a hydrogen atom from any carbon atom." [] subset: 3_STAR synonym: "alkyl group" EXACT IUPAC_NAME [IUPAC] synonym: "alkyl groups" EXACT IUPAC_NAME [IUPAC] synonym: "groupe alkyle" RELATED [IUPAC] synonym: "grupo alquilo" RELATED [IUPAC] synonym: "grupos alquilo" RELATED [IUPAC] is_a: CHEBI:33248 ! hydrocarbyl group relationship: is_substituent_group_from CHEBI:18310 ! alkane [Term] id: CHEBI:22390 name: alpha-D-glucoside namespace: chebi_ontology subset: 3_STAR synonym: "alpha-D-glucoside" EXACT [ChEBI] synonym: "alpha-D-glucosides" RELATED [ChEBI] synonym: "an alpha-D-glucoside" RELATED [UniProt] is_a: CHEBI:35436 ! D-glucoside is_a: CHEBI:60979 ! alpha-glucoside relationship: has_functional_parent CHEBI:17925 ! alpha-D-glucose [Term] id: CHEBI:22478 name: amino alcohol namespace: chebi_ontology def: "An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group." [] subset: 3_STAR synonym: "amino alcohols" RELATED [ChEBI] synonym: "aminoalcohol" RELATED [ChEBI] synonym: "aminoalcohols" RELATED [ChEBI] is_a: CHEBI:30879 ! alcohol is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:22479 name: amino cyclitol glycoside namespace: chebi_ontology subset: 3_STAR synonym: "amino cyclitol glycoside" EXACT [ChEBI] synonym: "amino cyclitol glycosides" RELATED [ChEBI] is_a: CHEBI:23451 ! cyclitol is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:22494 name: aminobenzoate namespace: chebi_ontology subset: 3_STAR synonym: "aminobenzoates" RELATED [ChEBI] is_a: CHEBI:22718 ! benzoates relationship: is_conjugate_base_of CHEBI:22495 ! aminobenzoic acid [Term] id: CHEBI:22495 name: aminobenzoic acid namespace: chebi_ontology subset: 3_STAR synonym: "Aminobenzoesaeure" RELATED [ChEBI] synonym: "aminobenzoic acid" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:22723 ! benzoic acids is_a: CHEBI:33856 ! aromatic amino acid relationship: is_conjugate_acid_of CHEBI:22494 ! aminobenzoate property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H7NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "137.136" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "137.04768" xsd:string [Term] id: CHEBI:22506 name: aminoglycan namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycans" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:65212 ! polysaccharide derivative [Term] id: CHEBI:22507 name: aminoglycoside antibiotic namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycoside antibiotics" RELATED [ChEBI] is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:47779 ! aminoglycoside [Term] id: CHEBI:22562 name: anilines namespace: chebi_ontology def: "Any aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:33860 ! aromatic amine [Term] id: CHEBI:22563 name: anion namespace: chebi_ontology def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." [] subset: 3_STAR synonym: "Anion" EXACT [ChEBI] synonym: "anion" EXACT IUPAC_NAME [IUPAC] synonym: "anion" EXACT [ChEBI] synonym: "Anionen" RELATED [ChEBI] synonym: "aniones" RELATED [ChEBI] synonym: "anions" RELATED [IUPAC] is_a: CHEBI:24870 ! ion [Term] id: CHEBI:22565 name: ansamycin namespace: chebi_ontology def: "A class of macrocyclic lactams that consist of an aromatic (phenyl or naphthyl) or quinonoid (benzoquinone or naphthoquinone) moiety that is bridged by an aliphatic chain." [] subset: 3_STAR xref: Wikipedia:Ansamycin is_a: CHEBI:24995 ! lactam is_a: CHEBI:26188 ! polyketide is_a: CHEBI:51026 ! macrocycle [Term] id: CHEBI:22586 name: antioxidant namespace: chebi_ontology def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." [] subset: 3_STAR synonym: "antioxidants" RELATED [ChEBI] synonym: "antioxydant" RELATED [ChEBI] synonym: "antoxidant" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22587 name: antiviral agent namespace: chebi_ontology def: "A substance that destroys or inhibits replication of viruses." [] subset: 3_STAR synonym: "anti-viral agent" RELATED [ChEBI] synonym: "anti-viral agents" RELATED [ChEBI] synonym: "antiviral" RELATED [ChEBI] synonym: "antiviral agents" RELATED [ChEBI] synonym: "antivirals" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:22601 name: arabinoside namespace: chebi_ontology subset: 3_STAR synonym: "arabinoside" EXACT [ChEBI] synonym: "arabinosides" RELATED [ChEBI] is_a: CHEBI:35312 ! pentoside [Term] id: CHEBI:22645 name: arenecarboxamide namespace: chebi_ontology def: "A monocarboxylic acid amide in which the amide linkage is bonded directly to an arene ring system." [] subset: 3_STAR synonym: "arenecarboxamides" RELATED [ChEBI] is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:62733 ! aromatic amide [Term] id: CHEBI:22695 name: base namespace: chebi_ontology def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." [] subset: 3_STAR synonym: "Base" EXACT [ChEBI] synonym: "base" EXACT [ChEBI] synonym: "base" EXACT IUPAC_NAME [IUPAC] synonym: "Base1" RELATED [KEGG_COMPOUND] synonym: "Base2" RELATED [KEGG_COMPOUND] synonym: "Basen" RELATED [ChEBI] synonym: "bases" RELATED [ChEBI] synonym: "Nucleobase" RELATED [KEGG_COMPOUND] xref: KEGG:C00701 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22702 name: benzamides namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22645 ! arenecarboxamide [Term] id: CHEBI:22712 name: benzenes namespace: chebi_ontology def: "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound [Term] id: CHEBI:22713 name: arenesulfonate oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "arenesulfonates" RELATED [ChEBI] is_a: CHEBI:33554 ! organosulfonate oxoanion relationship: is_conjugate_base_of CHEBI:33555 ! arenesulfonic acid [Term] id: CHEBI:22715 name: benzimidazoles namespace: chebi_ontology def: "An organic heterocyclic compound containing a benzene ring fused to an imidazole ring." [] subset: 3_STAR is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:22718 name: benzoates namespace: chebi_ontology def: "A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid." [] subset: 3_STAR synonym: "benzoate anion" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:91007 ! aromatic carboxylate [Term] id: CHEBI:22723 name: benzoic acids namespace: chebi_ontology def: "Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:33859 ! aromatic carboxylic acid [Term] id: CHEBI:22727 name: benzopyran namespace: chebi_ontology subset: 3_STAR synonym: "benzopyrans" RELATED [ChEBI] xref: Wikipedia:Benzopyran is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:22728 name: benzopyrrole namespace: chebi_ontology subset: 3_STAR synonym: "benzopyrroles" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38180 ! polycyclic heteroarene [Term] id: CHEBI:22888 name: biphenyls namespace: chebi_ontology def: "Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound is_a: CHEBI:36820 ! ring assembly is_a: CHEBI:64459 ! biaryl [Term] id: CHEBI:22907 name: bleomycin namespace: chebi_ontology alt_id: CHEBI:584977 def: "A glycopeptide produced by the bacterium Streptomyces verticillus. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2." [] subset: 3_STAR xref: DrugBank:DB00290 xref: Wikipedia:Bleomycin is_a: CHEBI:23089 ! chelate-forming peptide is_a: CHEBI:24396 ! glycopeptide [Term] id: CHEBI:22917 name: phytogenic insecticide namespace: chebi_ontology def: "An insecticide compound naturally occurring in plants." [] subset: 3_STAR synonym: "botanical insecticide" RELATED [ChEBI] synonym: "botanical insecticides" RELATED [ChEBI] synonym: "phytogenic insecticides" RELATED [ChEBI] is_a: CHEBI:24852 ! insecticide [Term] id: CHEBI:22944 name: butanediols namespace: chebi_ontology def: "A diol that is a butanediol or a derivative of a butanediol." [] subset: 3_STAR is_a: CHEBI:23824 ! diol [Term] id: CHEBI:22986 name: calcium ionophore namespace: chebi_ontology subset: 3_STAR synonym: "calcium ionophores" RELATED [ChEBI] is_a: CHEBI:24869 ! ionophore [Term] id: CHEBI:23003 name: carbamate ester namespace: chebi_ontology def: "Any ester of carbamic acid or its N-substituted derivatives." [] subset: 3_STAR synonym: "carbamate esters" RELATED [ChEBI] synonym: "carbamates" RELATED [ChEBI] xref: Wikipedia:Carbamate is_a: CHEBI:33308 ! carboxylic ester relationship: has_functional_parent CHEBI:28616 ! carbamic acid [Term] id: CHEBI:23004 name: carbamoyl group namespace: chebi_ontology def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." [] subset: 3_STAR synonym: "-C(O)NH2" RELATED [ChEBI] synonym: "-CONH2" RELATED [IUPAC] synonym: "aminocarbonyl" RELATED [IUPAC] synonym: "carbamoyl" EXACT IUPAC_NAME [IUPAC] synonym: "carbamyl" RELATED [ChEBI] synonym: "carbamyl group" RELATED [ChEBI] synonym: "carboxamide" RELATED [IUPAC] xref: PMID:24168430 {source="Europe PMC"} is_a: CHEBI:27207 ! univalent carboacyl group relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.03272" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.01364" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(N)=O" xsd:string [Term] id: CHEBI:23007 name: carbohydrate-containing antibiotic namespace: chebi_ontology def: "Any carbohydrate derivative that exhibits antibiotic activity." [] subset: 3_STAR is_a: CHEBI:63299 ! carbohydrate derivative relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:23018 name: EC 4.2.1.1 (carbonic anhydrase) inhibitor namespace: chebi_ontology def: "An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule." [] subset: 3_STAR synonym: "anhydrase inhibitor" RELATED [ChEBI] synonym: "anhydrase inhibitors" RELATED [ChEBI] synonym: "carbonate anhydrase inhibitor" RELATED [ChEBI] synonym: "carbonate anhydrase inhibitors" RELATED [ChEBI] synonym: "carbonate dehydratase inhibitor" RELATED [ChEBI] synonym: "carbonate dehydratase inhibitors" RELATED [ChEBI] synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitor" RELATED [ChEBI] synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitors" RELATED [ChEBI] synonym: "carbonate hydro-lyase inhibitor" RELATED [ChEBI] synonym: "carbonate hydro-lyase inhibitors" RELATED [ChEBI] synonym: "carbonic acid anhydrase inhibitor" RELATED [ChEBI] synonym: "carbonic acid anhydrase inhibitors" RELATED [ChEBI] synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitor" RELATED [ChEBI] synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitors" RELATED [ChEBI] synonym: "carbonic anhydrase A inhibitor" RELATED [ChEBI] synonym: "carbonic anhydrase A inhibitors" RELATED [ChEBI] synonym: "carbonic anhydrase inhibitor" RELATED [ChEBI] synonym: "carbonic anhydrase inhibitors" RELATED [ChEBI] synonym: "carboxyanhydrase inhibitor" RELATED [ChEBI] synonym: "carboxyanhydrase inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.1 (carbonic anhydrase) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.1 inhibitor" RELATED [ChEBI] synonym: "EC 4.2.1.1 inhibitors" RELATED [ChEBI] xref: Wikipedia:Carbonic_anhydrase_inhibitor is_a: CHEBI:76907 ! EC 4.2.1.* (hydro-lyases) inhibitor [Term] id: CHEBI:23019 name: carbonyl group namespace: chebi_ontology subset: 3_STAR synonym: ">C=O" RELATED [IUPAC] synonym: "carbonyl" EXACT IUPAC_NAME [IUPAC] synonym: "carbonyl group" EXACT [ChEBI] synonym: "carbonyl group" EXACT [UniProt] is_a: CHEBI:51422 ! organodiyl group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C(*)*" xsd:string [Term] id: CHEBI:23066 name: cephalosporin namespace: chebi_ontology alt_id: CHEBI:3538 def: "A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy." [] subset: 3_STAR synonym: "cephalosphorin" RELATED [ChEBI] synonym: "cephalosphorins" RELATED [ChEBI] synonym: "Cephalosporin" EXACT [KEGG_COMPOUND] synonym: "cephalosporins" RELATED [ChEBI] xref: KEGG:C00875 xref: PMID:10069359 {source="Europe PMC"} xref: PMID:11936371 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:24269048 {source="Europe PMC"} xref: PMID:3320614 {source="Europe PMC"} xref: PMID:6762896 {source="Europe PMC"} xref: PMID:8426246 {source="Europe PMC"} xref: Wikipedia:Cephalosporin is_a: CHEBI:38311 ! cephem relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H5NO3SR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "183.18500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "182.99901" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC([*])=C(N1C(=O)[C@H]2[*])C(O)=O" xsd:string [Term] id: CHEBI:23089 name: chelate-forming peptide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25903 ! peptide antibiotic relationship: RO:0000087 CHEBI:38161 ! has role chelator [Term] id: CHEBI:23114 name: chloride salt namespace: chebi_ontology subset: 3_STAR synonym: "chloride salts" RELATED [ChEBI] synonym: "chlorides" RELATED [ChEBI] is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:33958 ! halide salt relationship: has_part CHEBI:17996 ! chloride [Term] id: CHEBI:23116 name: chlorine atom namespace: chebi_ontology subset: 3_STAR synonym: "17Cl" RELATED [IUPAC] synonym: "Chlor" RELATED [ChEBI] synonym: "chlore" RELATED [ChEBI] synonym: "chlorine" EXACT IUPAC_NAME [IUPAC] synonym: "chlorine" RELATED [ChEBI] synonym: "chlorum" RELATED [ChEBI] synonym: "Cl" RELATED [IUPAC] synonym: "cloro" RELATED [ChEBI] xref: WebElements:Cl is_a: CHEBI:24473 ! halogen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cl" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZAMOUSCENKQFHK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "35.45270" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96885" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cl]" xsd:string [Term] id: CHEBI:23117 name: chlorine molecular entity namespace: chebi_ontology def: "A halogen molecular entity containing one or more atoms of chlorine." [] subset: 3_STAR is_a: CHEBI:24471 ! halogen molecular entity relationship: has_part CHEBI:23116 ! chlorine atom [Term] id: CHEBI:23132 name: chlorobenzenes namespace: chebi_ontology def: "Any organochlorine compound containing a benzene ring which is substituted by one or more chlorines." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:36683 ! organochlorine compound [Term] id: CHEBI:23213 name: choline ester namespace: chebi_ontology alt_id: CHEBI:3666 subset: 3_STAR synonym: "choline esters" RELATED [ChEBI] is_a: CHEBI:35701 ! ester relationship: has_functional_parent CHEBI:15354 ! choline [Term] id: CHEBI:23217 name: cholines namespace: chebi_ontology def: "A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof." [] subset: 3_STAR is_a: CHEBI:35267 ! quaternary ammonium ion [Term] id: CHEBI:23232 name: chromenes namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38443 ! 1-benzopyran [Term] id: CHEBI:23239 name: chromopeptide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25903 ! peptide antibiotic [Term] id: CHEBI:23357 name: cofactor namespace: chebi_ontology def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." [] subset: 3_STAR synonym: "cofactor" EXACT [IUPAC] synonym: "cofactors" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Cofactor_(biochemistry) is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:23366 name: compatible osmolytes namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25728 ! osmolyte [Term] id: CHEBI:23367 name: molecular entity namespace: chebi_ontology def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [] subset: 3_STAR synonym: "entidad molecular" RELATED [IUPAC] synonym: "entidades moleculares" RELATED [IUPAC] synonym: "entite moleculaire" RELATED [IUPAC] synonym: "molecular entities" RELATED [IUPAC] synonym: "molecular entity" EXACT IUPAC_NAME [IUPAC] synonym: "molekulare Entitaet" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:23377 name: copper molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "copper compounds" RELATED [ChEBI] synonym: "copper molecular entities" RELATED [ChEBI] synonym: "copper molecular entity" EXACT [ChEBI] is_a: CHEBI:33745 ! copper group molecular entity relationship: has_part CHEBI:28694 ! copper atom [Term] id: CHEBI:23378 name: copper cation namespace: chebi_ontology subset: 3_STAR synonym: "copper cation" EXACT IUPAC_NAME [IUPAC] synonym: "copper cations" RELATED [ChEBI] synonym: "Cu cation" RELATED [UniProt] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:37404 ! elemental copper relationship: RO:0000087 CHEBI:23357 ! has role cofactor property_value: http://purl.obolibrary.org/obo/chebi/formula "Cu" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "63.546" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.92960" xsd:string [Term] id: CHEBI:23403 name: coumarins namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26004 ! phenylpropanoid is_a: CHEBI:38445 ! chromenone [Term] id: CHEBI:23414 name: copper(II) sulfate namespace: chebi_ontology def: "A metal sulfate compound having copper(2+) as the metal ion." [] subset: 3_STAR synonym: "copper sulfate" RELATED [ChemIDplus] synonym: "copper(2+) sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "Copper(II) sulfate" EXACT [KEGG_COMPOUND] synonym: "copper(II) sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "Cupric sulfate" RELATED [ChemIDplus] synonym: "cupric sulfate anhydrous" RELATED [ChemIDplus] synonym: "CuSO4" RELATED [IUPAC] xref: CAS:7758-98-7 {source="ChemIDplus"} xref: CAS:7758-98-7 {source="KEGG COMPOUND"} xref: Gmelin:8294 {source="Gmelin"} xref: KEGG:C18713 xref: PMID:10469300 {source="Europe PMC"} xref: PMID:29079364 {source="Europe PMC"} xref: PMID:8566016 {source="Europe PMC"} xref: PPDB:178 xref: Wikipedia:Copper(II)_sulfate is_a: CHEBI:51336 ! metal sulfate relationship: has_part CHEBI:29036 ! copper(2+) relationship: RO:0000087 CHEBI:139492 ! has role sensitiser relationship: RO:0000087 CHEBI:149552 ! has role emetic relationship: RO:0000087 CHEBI:33287 ! has role fertilizer property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CuO4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cu.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ARUVKPQLZAKDPS-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "159.60960" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "158.88133" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cu++].[O-]S([O-])(=O)=O" xsd:string [Term] id: CHEBI:23424 name: cyanides namespace: chebi_ontology def: "Salts and C-organyl derivatives of hydrogen cyanide, HC#N." [] subset: 3_STAR synonym: "cyanides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35352 ! organonitrogen compound relationship: has_parent_hydride CHEBI:18407 ! hydrogen cyanide [Term] id: CHEBI:23443 name: cyclic amide namespace: chebi_ontology alt_id: CHEBI:3990 subset: 3_STAR synonym: "cyclic amide" EXACT [ChEBI] synonym: "cyclic amides" RELATED [ChEBI] is_a: CHEBI:32988 ! amide [Term] id: CHEBI:23447 name: cyclic nucleotide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic nucleotides" RELATED [ChEBI] is_a: CHEBI:36976 ! nucleotide [Term] id: CHEBI:23449 name: cyclic peptide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic peptides" RELATED [ChEBI] synonym: "Cyclopeptid" RELATED [ChEBI] synonym: "peptide cyclique" RELATED [IUPAC] synonym: "peptido ciclico" RELATED [IUPAC] synonym: "Zyklopeptid" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:23451 name: cyclitol namespace: chebi_ontology def: "A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom." [] subset: 3_STAR synonym: "cyclitols" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:23503 name: 4-amino-1,2-oxazolidin-3-one namespace: chebi_ontology def: "A member of the class of oxazolidines that is isoxazoldin-3-one which is substituted at position 4 by an amino group." [] subset: 3_STAR synonym: "4-amino-1,2-oxazolidin-3-one" EXACT IUPAC_NAME [IUPAC] synonym: "cycloserine" RELATED [ChEBI] xref: CAS:68-39-3 {source="KEGG COMPOUND"} xref: KEGG:C06682 is_a: CHEBI:26649 ! serine derivative is_a: CHEBI:38329 ! oxazolidines is_a: CHEBI:50994 ! primary amino compound is_a: CHEBI:75606 ! hydroxamic acid ester property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYDCUQKUCUHJBH-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "102.09190" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.04293" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC1CONC1=O" xsd:string [Term] id: CHEBI:23636 name: deoxyribonucleoside namespace: chebi_ontology subset: 3_STAR synonym: "deoxyribonucleosides" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside [Term] id: CHEBI:23643 name: depsipeptide namespace: chebi_ontology def: "A natural or synthetic compound having a sequence of amino and hydroxy carboxylic acid residues (usually alpha-amino and alpha-hydroxy acids), commonly but not necessarily regularly alternating." [] subset: 3_STAR synonym: "Depsipeptid" RELATED [ChEBI] synonym: "depsipeptides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:23666 name: diamine namespace: chebi_ontology def: "Any polyamine that contains two amino groups." [] subset: 3_STAR synonym: "diamines" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:88061 ! polyamine [Term] id: CHEBI:23677 name: diazole namespace: chebi_ontology def: "An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring." [] subset: 3_STAR synonym: "diazoles" RELATED [ChEBI] is_a: CHEBI:68452 ! azole [Term] id: CHEBI:23697 name: dichlorobenzene namespace: chebi_ontology def: "Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions." [] subset: 3_STAR synonym: "Dichlorbenzol" RELATED [ChEBI] synonym: "dichlorobenzene" EXACT IUPAC_NAME [IUPAC] synonym: "dichlorobenzene" EXACT [ChEBI] synonym: "dichlorobenzenes" RELATED [ChEBI] is_a: CHEBI:23132 ! chlorobenzenes [Term] id: CHEBI:23763 name: pyrroline namespace: chebi_ontology def: "Any organic heteromonocyclic compound with a structure based on a dihydropyrrole." [] subset: 3_STAR synonym: "dihydropyrrole" RELATED [ChemIDplus] synonym: "pyrroline" EXACT [ChemIDplus] synonym: "pyrrolines" RELATED [ChEBI] xref: CAS:28350-87-0 {source="ChemIDplus"} xref: Wikipedia:Pyrroline is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H7N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "69.105" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "69.05785" xsd:string [Term] id: CHEBI:23765 name: quinolone namespace: chebi_ontology subset: 3_STAR synonym: "quinolones" RELATED [ChEBI] is_a: CHEBI:26513 ! quinolines [Term] id: CHEBI:23824 name: diol namespace: chebi_ontology def: "A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols." [] subset: 3_STAR synonym: "diols" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Diol is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:23849 name: diterpenoid namespace: chebi_ontology def: "Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." [] subset: 3_STAR synonym: "C20 isoprenoids" RELATED [LIPID_MAPS] synonym: "diterpenoides" RELATED [ChEBI] synonym: "diterpenoids" EXACT IUPAC_NAME [IUPAC] xref: LIPID_MAPS_class:LMPR0104 {source="LIPID MAPS"} is_a: CHEBI:26873 ! terpenoid relationship: has_parent_hydride CHEBI:35190 ! diterpene [Term] id: CHEBI:23853 name: dithiol namespace: chebi_ontology subset: 3_STAR synonym: "dithiols" RELATED [ChEBI] is_a: CHEBI:29256 ! thiol [Term] id: CHEBI:23870 name: dodecyl group namespace: chebi_ontology subset: 3_STAR synonym: "CH3-[CH2]11-" RELATED [IUPAC] synonym: "Dod" RELATED [CBN] synonym: "dodecan-1-yl" RELATED [ChEBI] synonym: "dodecyl" EXACT IUPAC_NAME [IUPAC] synonym: "lauryl" RELATED [ChEBI] is_a: CHEBI:22323 ! alkyl group relationship: is_substituent_group_from CHEBI:28817 ! dodecane property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H25" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "169.32690" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "169.19563" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCC*" xsd:string [Term] id: CHEBI:23872 name: dodecyl sulfate namespace: chebi_ontology subset: 3_STAR synonym: "dodecyl sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "dodecyl sulfate" EXACT [UniProt] xref: Beilstein:1820003 {source="Beilstein"} xref: DrugBank:DB03967 xref: Gmelin:336103 {source="Gmelin"} xref: UM-BBD_compID:c0563 {source="UM-BBD"} is_a: CHEBI:58958 ! organosulfate oxoanion relationship: is_conjugate_base_of CHEBI:45599 ! dodecyl hydrogen sulfate relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H25O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H26O4S/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15/h2-12H2,1H3,(H,13,14,15)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MOTZDAYCYVMXPC-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "265.39050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "265.14790" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCOS([O-])(=O)=O" xsd:string [Term] id: CHEBI:23888 name: drug namespace: chebi_ontology def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." [] subset: 3_STAR synonym: "drugs" RELATED [ChEBI] synonym: "medicine" RELATED [ChEBI] is_a: CHEBI:52217 ! pharmaceutical [Term] id: CHEBI:23905 name: monoatomic anion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:24867 ! monoatomic ion [Term] id: CHEBI:23906 name: monoatomic cation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic cations" RELATED [ChEBI] is_a: CHEBI:24867 ! monoatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:23924 name: enzyme inhibitor namespace: chebi_ontology def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." [] subset: 3_STAR synonym: "enzyme inhibitor" EXACT IUPAC_NAME [IUPAC] synonym: "enzyme inhibitors" RELATED [ChEBI] synonym: "inhibidor enzimatico" RELATED [ChEBI] synonym: "inhibidores enzimaticos" RELATED [ChEBI] synonym: "inhibiteur enzymatique" RELATED [ChEBI] synonym: "inhibiteurs enzymatiques" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:23953 name: erythromycins namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25105 ! macrolide antibiotic relationship: has_functional_parent CHEBI:23955 ! erythronolide [Term] id: CHEBI:23955 name: erythronolide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:23981 name: ethanolamines namespace: chebi_ontology subset: 3_STAR synonym: "ethanolamine" RELATED [ChEBI] is_a: CHEBI:22478 ! amino alcohol [Term] id: CHEBI:24061 name: fluorine atom namespace: chebi_ontology subset: 3_STAR synonym: "9F" RELATED [IUPAC] synonym: "F" RELATED [IUPAC] synonym: "Fluor" RELATED [ChemIDplus] synonym: "fluor" RELATED [ChEBI] synonym: "fluorine" EXACT IUPAC_NAME [IUPAC] synonym: "fluorine" RELATED [ChEBI] synonym: "fluorum" RELATED [ChEBI] xref: CAS:7782-41-4 {source="ChemIDplus"} xref: WebElements:F is_a: CHEBI:24473 ! halogen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "F" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/F" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YCKRFDGAMUMZLT-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "18.99840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[F]" xsd:string [Term] id: CHEBI:24062 name: fluorine molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "fluorine compounds" RELATED [ChEBI] synonym: "fluorine molecular entities" RELATED [ChEBI] synonym: "fluorine molecular entity" EXACT [ChEBI] is_a: CHEBI:24471 ! halogen molecular entity relationship: has_part CHEBI:24061 ! fluorine atom [Term] id: CHEBI:24068 name: fluoroamino acid namespace: chebi_ontology def: "An organofluorine compound that consists of an amino acid substituted by a fluoro group." [] subset: 3_STAR synonym: "fluoroamino acids" RELATED [ChEBI] is_a: CHEBI:24470 ! haloamino acid is_a: CHEBI:37143 ! organofluorine compound [Term] id: CHEBI:24079 name: formamides namespace: chebi_ontology def: "Amides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H)." [] subset: 3_STAR is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:24127 name: fungicide namespace: chebi_ontology def: "A substance used to destroy fungal pests." [] subset: 3_STAR synonym: "fungicides" RELATED [ChEBI] is_a: CHEBI:25944 ! pesticide is_a: CHEBI:35718 ! antifungal agent [Term] id: CHEBI:24129 name: furans namespace: chebi_ontology def: "Compounds containing at least one furan ring." [] subset: 3_STAR synonym: "oxacyclopenta-2,4-dienes" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:24271 name: glucosamines namespace: chebi_ontology def: "Any hexosamine that is glucose in which at least one of the hydroxy groups has been replaced by an amino group." [] subset: 3_STAR is_a: CHEBI:24586 ! hexosamine [Term] id: CHEBI:24278 name: glucoside namespace: chebi_ontology subset: 3_STAR synonym: "glucosides" RELATED [ChEBI] is_a: CHEBI:35313 ! hexoside [Term] id: CHEBI:24318 name: glutamine family amino acid namespace: chebi_ontology def: "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." [] subset: 3_STAR synonym: "glutamine family amino acids" RELATED [ChEBI] xref: PMID:20716061 {source="Europe PMC"} is_a: CHEBI:15705 ! L-alpha-amino acid is_a: CHEBI:83813 ! proteinogenic amino acid [Term] id: CHEBI:24396 name: glycopeptide namespace: chebi_ontology alt_id: CHEBI:24395 alt_id: CHEBI:5478 def: "Any carbohydrate derivative that consists of glycan moieties covalently attached to the side chains of the amino acid residues that constitute the peptide." [] subset: 3_STAR synonym: "glycopeptides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:16670 ! peptide is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:24400 name: glycoside namespace: chebi_ontology def: "A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively." [] subset: 3_STAR synonym: "glycosides" EXACT IUPAC_NAME [IUPAC] synonym: "glycosides" RELATED [ChEBI] synonym: "O-glycoside" RELATED [ChEBI] synonym: "O-glycosides" RELATED [ChEBI] is_a: CHEBI:63161 ! glycosyl compound [Term] id: CHEBI:24431 name: chemical entity namespace: chebi_ontology def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [] subset: 3_STAR synonym: "chemical entity" EXACT [UniProt] is_a: BFO:0000040 ! material entity [Term] id: CHEBI:24432 name: biological role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a biological context." [] subset: 3_STAR synonym: "biological function" RELATED [ChEBI] is_a: BFO:0000023 ! role is_a: CHEBI:50906 ! role [Term] id: CHEBI:24433 name: group namespace: chebi_ontology def: "A defined linked collection of atoms or a single atom within a molecular entity." [] subset: 3_STAR synonym: "group" EXACT IUPAC_NAME [IUPAC] synonym: "groupe" RELATED [IUPAC] synonym: "grupo" RELATED [IUPAC] synonym: "grupos" RELATED [IUPAC] synonym: "Gruppe" RELATED [ChEBI] synonym: "Rest" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:33250 ! atom [Term] id: CHEBI:24436 name: guanidines namespace: chebi_ontology def: "Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas." [] subset: 3_STAR is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:24470 name: haloamino acid namespace: chebi_ontology def: "Any non-proteinogenic amino acid carrying at least one halo group." [] subset: 3_STAR synonym: "haloamino acids" RELATED [ChEBI] is_a: CHEBI:83820 ! non-proteinogenic amino acid [Term] id: CHEBI:24471 name: halogen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "halogen compounds" RELATED [ChEBI] synonym: "halogen molecular entities" RELATED [ChEBI] synonym: "halogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:24473 ! halogen [Term] id: CHEBI:24473 name: halogen namespace: chebi_ontology subset: 3_STAR synonym: "group 17 elements" RELATED [ChEBI] synonym: "group VII elements" RELATED [ChEBI] synonym: "halogen" EXACT IUPAC_NAME [IUPAC] synonym: "Halogene" RELATED [ChEBI] synonym: "halogene" RELATED [ChEBI] synonym: "halogenes" RELATED [ChEBI] synonym: "halogeno" RELATED [ChEBI] synonym: "halogenos" RELATED [ChEBI] synonym: "halogens" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:24531 name: heterocyclic antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24532 ! organic heterocyclic compound relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:24532 name: organic heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." [] subset: 3_STAR synonym: "organic heterocycle" RELATED [ChEBI] synonym: "organic heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33832 ! organic cyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:24533 name: heterodetic cyclic peptide namespace: chebi_ontology def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." [] subset: 3_STAR synonym: "heterodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC] synonym: "heterodetic cyclic peptides" RELATED [ChEBI] synonym: "peptide cyclique heterodetique" RELATED [IUPAC] synonym: "peptido ciclico heterodetico" RELATED [IUPAC] is_a: CHEBI:23449 ! cyclic peptide [Term] id: CHEBI:24583 name: hexitol namespace: chebi_ontology subset: 3_STAR synonym: "hexitol" EXACT [ChEBI] synonym: "hexitols" RELATED [ChEBI] is_a: CHEBI:17522 ! alditol [Term] id: CHEBI:24586 name: hexosamine namespace: chebi_ontology def: "Any 6-carbon amino monosaccharide with at least one alcoholic hydroxy group replaced by an amino group." [] subset: 3_STAR synonym: "hexosamine" EXACT [ChEBI] synonym: "hexosamines" RELATED [ChEBI] is_a: CHEBI:60926 ! amino monosaccharide [Term] id: CHEBI:24613 name: homodetic cyclic peptide namespace: chebi_ontology def: "A homodetic cyclic peptide is a cyclic peptide in which the ring consists solely of amino-acid residues in peptide linkages." [] subset: 3_STAR synonym: "homodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC] synonym: "homodetic cyclic peptides" RELATED [ChEBI] synonym: "peptide cyclique homodetique" RELATED [IUPAC] synonym: "peptido ciclico homodetico" RELATED [IUPAC] is_a: CHEBI:23449 ! cyclic peptide [Term] id: CHEBI:24621 name: hormone namespace: chebi_ontology def: "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." [] subset: 3_STAR synonym: "endocrine" RELATED [ChEBI] synonym: "hormones" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:24628 name: imidazolidine-2,4-dione namespace: chebi_ontology def: "An imidazolidinone with oxo groups at position 2 and 4." [] subset: 3_STAR is_a: CHEBI:55370 ! imidazolidinone [Term] id: CHEBI:24632 name: hydrocarbon namespace: chebi_ontology def: "A compound consisting of carbon and hydrogen only." [] subset: 3_STAR synonym: "hidrocarburo" RELATED [IUPAC] synonym: "hidrocarburos" RELATED [IUPAC] synonym: "hydrocarbon" EXACT IUPAC_NAME [IUPAC] synonym: "hydrocarbons" EXACT IUPAC_NAME [IUPAC] synonym: "hydrocarbure" RELATED [IUPAC] synonym: "Kohlenwasserstoff" RELATED [ChEBI] synonym: "Kohlenwasserstoffe" RELATED [ChEBI] is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:24648 name: hydroxamic acid anion namespace: chebi_ontology def: "An oxoanion resulting from the removal of a proton from the hydroxy group of any hydroxamic acid." [] subset: 3_STAR synonym: "hydroxamate" RELATED [ChEBI] synonym: "hydroxamates" RELATED [ChEBI] synonym: "hydroxamic acid anions" RELATED [ChEBI] synonym: "hydroxamic anion" RELATED [ChEBI] synonym: "hydroxamic anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion relationship: is_conjugate_base_of CHEBI:24650 ! hydroxamic acid [Term] id: CHEBI:24650 name: hydroxamic acid namespace: chebi_ontology def: "A compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides." [] subset: 3_STAR synonym: "hydroxamic acids" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxamic acids" RELATED [ChEBI] synonym: "N-hydroxy amide" RELATED [ChEBI] synonym: "N-hydroxy amides" RELATED [ChEBI] synonym: "N-hydroxy-amide" RELATED [ChEBI] synonym: "N-hydroxy-amides" RELATED [ChEBI] synonym: "N-hydroxyamide" RELATED [ChEBI] synonym: "N-hydroxyamides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide relationship: is_conjugate_acid_of CHEBI:24648 ! hydroxamic acid anion [Term] id: CHEBI:24651 name: hydroxides namespace: chebi_ontology def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." [] subset: 3_STAR is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:43176 ! hydroxy group [Term] id: CHEBI:24654 name: hydroxy fatty acid namespace: chebi_ontology def: "Any fatty acid carrying one or more hydroxy substituents." [] subset: 3_STAR synonym: "hydroxy fatty acids" RELATED [LIPID_MAPS] xref: LIPID_MAPS_class:LMFA0105 {source="LIPID MAPS"} xref: PMID:18296335 {source="Europe PMC"} xref: PMID:6419288 {source="Europe PMC"} xref: PMID:8274032 {source="Europe PMC"} is_a: CHEBI:35366 ! fatty acid is_a: CHEBI:35868 ! hydroxy monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:59835 ! hydroxy fatty acid anion [Term] id: CHEBI:24669 name: hydroxy carboxylic acid namespace: chebi_ontology def: "Any carboxylic acid with at least one hydroxy group." [] subset: 3_STAR synonym: "hydroxy carboxylic acids" RELATED [ChEBI] synonym: "hydroxycarboxylic acid" RELATED [ChEBI] synonym: "hydroxycarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:24675 name: hydroxybenzoate namespace: chebi_ontology def: "Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent." [] subset: 3_STAR synonym: "hydroxybenzoates" RELATED [ChEBI] is_a: CHEBI:22718 ! benzoates is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:24676 ! hydroxybenzoic acid [Term] id: CHEBI:24676 name: hydroxybenzoic acid namespace: chebi_ontology alt_id: CHEBI:50778 def: "Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring." [] subset: 3_STAR synonym: "hydroxybenzoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxybenzoic acids" RELATED [ChEBI] is_a: CHEBI:22723 ! benzoic acids is_a: CHEBI:33853 ! phenols relationship: has_functional_parent CHEBI:30746 ! benzoic acid relationship: is_conjugate_acid_of CHEBI:24675 ! hydroxybenzoate property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "138.121" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "138.03169" xsd:string [Term] id: CHEBI:2468 name: secondary alpha-hydroxy ketone namespace: chebi_ontology def: "An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing one hydrogen and one organyl group. Secondary alpha-hydroxy ketones are also known as acyloins, and are formally derived from reductive coupling of two carboxylic acid groups." [] subset: 3_STAR synonym: "acyloin" RELATED [ChEBI] synonym: "acyloins" RELATED [ChEBI] synonym: "secondary alpha-hydroxy ketones" RELATED [ChEBI] synonym: "secondary alpha-hydroxy-ketone" RELATED [ChEBI] synonym: "secondary alpha-hydroxy-ketones" RELATED [ChEBI] synonym: "secondary alpha-hydroxyketone" RELATED [ChEBI] synonym: "secondary alpha-hydroxyketones" RELATED [ChEBI] xref: Wikipedia:Acyloin is_a: CHEBI:139588 ! alpha-hydroxy ketone is_a: CHEBI:35681 ! secondary alcohol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H2O2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "58.036" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "58.00548" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C(=O)*)(O)([H])*" xsd:string [Term] id: CHEBI:24712 name: hydroxymethyl group namespace: chebi_ontology subset: 3_STAR synonym: "-CH2-OH" RELATED [IUPAC] synonym: "hydroxymethyl" EXACT IUPAC_NAME [IUPAC] synonym: "serine side-chain" RELATED [ChEBI] is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group relationship: is_substituent_group_from CHEBI:17790 ! methanol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "31.03392" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.01839" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(*)O" xsd:string [Term] id: CHEBI:24753 name: hygromycin namespace: chebi_ontology subset: 3_STAR synonym: "hygromycins" RELATED [ChEBI] is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:24780 name: imidazoles namespace: chebi_ontology def: "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [] subset: 3_STAR is_a: CHEBI:23677 ! diazole [Term] id: CHEBI:24782 name: imide namespace: chebi_ontology subset: 3_STAR synonym: "imide" EXACT [ChEBI] synonym: "imides" RELATED [ChEBI] is_a: CHEBI:33257 ! secondary amide [Term] id: CHEBI:24797 name: indole phytoalexin namespace: chebi_ontology subset: 3_STAR synonym: "indole phytoalexins" RELATED [ChEBI] is_a: CHEBI:24828 ! indoles relationship: RO:0000087 CHEBI:26115 ! has role phytoalexin [Term] id: CHEBI:24828 name: indoles namespace: chebi_ontology def: "Any compound containing an indole skeleton." [] subset: 3_STAR is_a: CHEBI:22728 ! benzopyrrole [Term] id: CHEBI:24833 name: oxoacid namespace: chebi_ontology def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [] subset: 3_STAR synonym: "oxacids" RELATED [ChEBI] synonym: "oxiacids" RELATED [ChEBI] synonym: "oxo acid" RELATED [ChEBI] synonym: "oxoacid" EXACT IUPAC_NAME [IUPAC] synonym: "oxoacids" EXACT IUPAC_NAME [IUPAC] synonym: "oxy-acids" RELATED [ChEBI] synonym: "oxyacids" RELATED [ChEBI] is_a: CHEBI:24651 ! hydroxides relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid [Term] id: CHEBI:24834 name: inorganic anion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36914 ! inorganic ion [Term] id: CHEBI:24835 name: inorganic molecular entity namespace: chebi_ontology def: "A molecular entity that contains no carbon." [] subset: 3_STAR synonym: "anorganische Verbindungen" RELATED [ChEBI] synonym: "inorganic compounds" RELATED [ChEBI] synonym: "inorganic entity" RELATED [ChEBI] synonym: "inorganic molecular entities" RELATED [ChEBI] synonym: "inorganics" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24836 name: inorganic oxide namespace: chebi_ontology subset: 3_STAR synonym: "inorganic oxides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25741 ! oxide [Term] id: CHEBI:24837 name: inorganic peroxide namespace: chebi_ontology def: "Compounds of structure ROOR' in which R and R' are inorganic groups." [] subset: 3_STAR synonym: "inorganic peroxide" EXACT [ChEBI] synonym: "inorganic peroxides" RELATED [ChEBI] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:25940 ! peroxides [Term] id: CHEBI:24839 name: inorganic salt namespace: chebi_ontology subset: 3_STAR synonym: "anorganisches Salz" RELATED [ChEBI] synonym: "inorganic salts" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24866 ! salt [Term] id: CHEBI:24840 name: inorganic sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "inorganic sulfate salts" RELATED [ChEBI] synonym: "inorganic sulfates" RELATED [ChEBI] is_a: CHEBI:24839 ! inorganic salt is_a: CHEBI:35175 ! sulfate salt [Term] id: CHEBI:24848 name: inositol namespace: chebi_ontology def: "Any cyclohexane-1,2,3,4,5,6-hexol." [] subset: 3_STAR synonym: "1,2,3,4,5,6-cyclohexanehexol" RELATED [ChEBI] synonym: "inositol" EXACT [IUBMB] synonym: "inositols" EXACT IUPAC_NAME [IUPAC] synonym: "inositols" RELATED [ChEBI] is_a: CHEBI:23451 ! cyclitol is_a: CHEBI:37206 ! hexol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CDAISMWEOUEBRE-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC1C(O)C(O)C(O)C(O)C1O" xsd:string [Term] id: CHEBI:24852 name: insecticide namespace: chebi_ontology def: "Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects." [] subset: 3_STAR synonym: "insecticides" RELATED [ChEBI] xref: Wikipedia:Insecticide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:24859 name: iodine atom namespace: chebi_ontology def: "Chemical element with atomic number 53." [] subset: 3_STAR synonym: "53I" RELATED [IUPAC] synonym: "I" RELATED [ChEBI] synonym: "Iod" RELATED [ChEBI] synonym: "iode" RELATED [ChEBI] synonym: "iodine" EXACT IUPAC_NAME [IUPAC] synonym: "iodine" RELATED [ChEBI] synonym: "iodium" RELATED [ChEBI] synonym: "J" RELATED [ChEBI] synonym: "Jod" RELATED [ChEBI] synonym: "yodo" RELATED [ChEBI] xref: WebElements:I is_a: CHEBI:24473 ! halogen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "I" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/I" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZCYVEMRRCGMTRW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "126.90447" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "126.90447" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[I]" xsd:string [Term] id: CHEBI:24860 name: iodine molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "iodine compounds" RELATED [ChEBI] synonym: "iodine molecular entities" RELATED [ChEBI] synonym: "iodine molecular entity" EXACT [ChEBI] is_a: CHEBI:24471 ! halogen molecular entity relationship: has_part CHEBI:24859 ! iodine atom [Term] id: CHEBI:24866 name: salt namespace: chebi_ontology def: "A salt is an assembly of cations and anions." [] subset: 3_STAR synonym: "ionic compound" RELATED [ChEBI] synonym: "ionic compounds" RELATED [ChEBI] synonym: "sal" RELATED [ChEBI] synonym: "sales" RELATED [ChEBI] synonym: "salt" EXACT IUPAC_NAME [IUPAC] synonym: "salts" RELATED [ChEBI] synonym: "Salz" RELATED [ChEBI] synonym: "Salze" RELATED [ChEBI] synonym: "sel" RELATED [ChEBI] synonym: "sels" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:22563 ! anion relationship: has_part CHEBI:36916 ! cation [Term] id: CHEBI:24867 name: monoatomic ion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:33238 ! monoatomic entity [Term] id: CHEBI:24868 name: organic salt namespace: chebi_ontology subset: 3_STAR synonym: "organic salts" RELATED [ChEBI] synonym: "organisches Salz" RELATED [ChEBI] is_a: CHEBI:24866 ! salt [Term] id: CHEBI:24869 name: ionophore namespace: chebi_ontology def: "A compound which can carry specific ions through membranes of cells or organelles." [] subset: 3_STAR synonym: "ionophore" EXACT IUPAC_NAME [IUPAC] synonym: "ionophores" RELATED [ChEBI] xref: Wikipedia:Ionophore is_a: CHEBI:38632 ! membrane transport modulator [Term] id: CHEBI:24870 name: ion namespace: chebi_ontology def: "A molecular entity having a net electric charge." [] subset: 3_STAR synonym: "Ion" EXACT [ChEBI] synonym: "ion" EXACT IUPAC_NAME [IUPAC] synonym: "ion" EXACT [ChEBI] synonym: "Ionen" RELATED [ChEBI] synonym: "iones" RELATED [ChEBI] synonym: "ions" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24897 name: isoindoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22728 ! benzopyrrole [Term] id: CHEBI:24913 name: isoprenoid namespace: chebi_ontology def: "Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives." [] subset: 3_STAR synonym: "isoprenoid" EXACT [ChEBI] synonym: "isoprenoids" EXACT IUPAC_NAME [IUPAC] synonym: "isoprenoids" RELATED [ChEBI] xref: LIPID_MAPS_class:LMPR01 {source="LIPID MAPS"} xref: PMID:12769708 {source="Europe PMC"} xref: PMID:19219049 {source="Europe PMC"} is_a: CHEBI:18059 ! lipid [Term] id: CHEBI:24951 name: kanamycins namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:24995 name: lactam namespace: chebi_ontology def: "Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [] subset: 3_STAR synonym: "lactam" EXACT [IUPAC] synonym: "lactams" EXACT IUPAC_NAME [IUPAC] synonym: "lactams" RELATED [ChEBI] synonym: "Laktam" RELATED [ChEBI] synonym: "Laktame" RELATED [ChEBI] is_a: CHEBI:23443 ! cyclic amide is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:25000 name: lactone namespace: chebi_ontology def: "Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [] subset: 3_STAR synonym: "Lacton" RELATED [ChEBI] synonym: "lactona" RELATED [IUPAC] synonym: "lactonas" RELATED [IUPAC] synonym: "lactone" EXACT IUPAC_NAME [IUPAC] synonym: "lactones" EXACT IUPAC_NAME [IUPAC] synonym: "Lakton" RELATED [ChEBI] synonym: "Laktone" RELATED [ChEBI] is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:25022 name: leucomycin namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:25061 name: lipopeptide antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:46895 ! lipopeptide [Term] id: CHEBI:25105 name: macrolide antibiotic namespace: chebi_ontology def: "A macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity." [] subset: 3_STAR synonym: "macrolide antibiotics" RELATED [ChEBI] synonym: "Makrolidantibiotika" RELATED [ChEBI] is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:25106 name: macrolide namespace: chebi_ontology def: "A macrocyclic lactone with a ring of twelve or more members derived from a polyketide." [] subset: 3_STAR synonym: "macrolide" EXACT [ChEBI] synonym: "macrolides" EXACT IUPAC_NAME [IUPAC] synonym: "macrolides" RELATED [ChEBI] synonym: "Makrolid" RELATED [ChEBI] xref: Wikipedia:Macrolide is_a: CHEBI:26188 ! polyketide is_a: CHEBI:63944 ! macrocyclic lactone [Term] id: CHEBI:25154 name: manganese molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "manganese compounds" RELATED [ChEBI] synonym: "manganese molecular entities" RELATED [ChEBI] synonym: "manganese molecular entity" EXACT [ChEBI] is_a: CHEBI:33743 ! manganese group molecular entity relationship: has_part CHEBI:18291 ! manganese atom [Term] id: CHEBI:25189 name: 1,4-dimercaptobutane-2,3-diol namespace: chebi_ontology def: "A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group." [] subset: 3_STAR synonym: "1,4-dimercapto-2,3-butanediol" RELATED [ChemIDplus] synonym: "1,4-dimercaptobutane-2,3-diol" EXACT [ChemIDplus] synonym: "1,4-disulfanylbutane-2,3-diol" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:8141671 {source="Beilstein"} xref: CAS:7634-42-6 {source="ChemIDplus"} is_a: CHEBI:13643 ! glycol is_a: CHEBI:22944 ! butanediols is_a: CHEBI:29256 ! thiol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H10O2S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VHJLVAABSRFDPM-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "154.25300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "154.01222" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(CS)C(O)CS" xsd:string [Term] id: CHEBI:25212 name: metabolite namespace: chebi_ontology alt_id: CHEBI:26619 alt_id: CHEBI:35220 def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." [] subset: 3_STAR synonym: "metabolite" EXACT IUPAC_NAME [IUPAC] synonym: "metabolites" RELATED [ChEBI] synonym: "primary metabolites" RELATED [ChEBI] synonym: "secondary metabolites" RELATED [ChEBI] is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:25213 name: metal cation namespace: chebi_ontology subset: 3_STAR synonym: "a metal cation" RELATED [UniProt] synonym: "metal cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:25248 name: methyl ester namespace: chebi_ontology def: "Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol." [] subset: 3_STAR synonym: "carboxylic acid methyl ester" RELATED [ChEBI] synonym: "carboxylic acid methyl esters" RELATED [ChEBI] is_a: CHEBI:33308 ! carboxylic ester relationship: has_functional_parent CHEBI:17790 ! methanol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3O2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "59.044" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.01330" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC([*])=O" xsd:string [Term] id: CHEBI:25355 name: mitochondrial respiratory-chain inhibitor namespace: chebi_ontology subset: 3_STAR synonym: "mitochondrial electron transport chain inhibitors" RELATED [ChEBI] synonym: "mitochondrial electron-transport chain inhibitor" RELATED [ChEBI] synonym: "mitochondrial respiratory chain inhibitors" RELATED [ChEBI] is_a: CHEBI:38497 ! respiratory-chain inhibitor [Term] id: CHEBI:25367 name: molecule namespace: chebi_ontology def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." [] subset: 3_STAR synonym: "molecula" RELATED [IUPAC] synonym: "molecule" EXACT [IUPAC] synonym: "molecules" RELATED [IUPAC] synonym: "Molekuel" RELATED [ChEBI] synonym: "neutral molecular compounds" RELATED [IUPAC] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:25384 name: monocarboxylic acid namespace: chebi_ontology def: "An oxoacid containing a single carboxy group." [] subset: 3_STAR synonym: "monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion [Term] id: CHEBI:25388 name: monohydroxybenzoate namespace: chebi_ontology def: "A hydroxybenzoate carrying a single hydroxy substituent at unspecified position." [] subset: 3_STAR synonym: "monohydroxybenzoates" RELATED [ChEBI] is_a: CHEBI:24675 ! hydroxybenzoate relationship: is_conjugate_base_of CHEBI:25389 ! monohydroxybenzoic acid [Term] id: CHEBI:25389 name: monohydroxybenzoic acid namespace: chebi_ontology def: "Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring." [] subset: 3_STAR synonym: "monohydroxybenzoic acids" RELATED [ChEBI] is_a: CHEBI:24676 ! hydroxybenzoic acid relationship: is_conjugate_acid_of CHEBI:25388 ! monohydroxybenzoate [Term] id: CHEBI:25414 name: monoatomic monocation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic monocations" RELATED [ChEBI] synonym: "monovalent inorganic cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*+]" xsd:string [Term] id: CHEBI:25435 name: mutagen namespace: chebi_ontology def: "An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution." [] subset: 3_STAR synonym: "mutagene" RELATED [ChEBI] synonym: "mutagenes" RELATED [ChEBI] synonym: "mutagenic agent" RELATED [ChEBI] synonym: "mutageno" RELATED [ChEBI] synonym: "mutagenos" RELATED [ChEBI] synonym: "mutagens" RELATED [ChEBI] xref: Wikipedia:Mutagen is_a: CHEBI:50902 ! genotoxin [Term] id: CHEBI:25442 name: mycotoxin namespace: chebi_ontology def: "Poisonous substance produced by fungi." [] subset: 3_STAR synonym: "fungal toxins" RELATED [ChEBI] synonym: "mycotoxins" RELATED [ChEBI] is_a: CHEBI:27026 ! toxin is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:25471 name: naphthalenemonosulfonate namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25478 ! naphthalenesulfonate [Term] id: CHEBI:25477 name: naphthalenes namespace: chebi_ontology def: "Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound is_a: CHEBI:36785 ! carbobicyclic compound [Term] id: CHEBI:25478 name: naphthalenesulfonate namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:22713 ! arenesulfonate oxoanion [Term] id: CHEBI:25481 name: naphthoquinone namespace: chebi_ontology def: "A polycyclic aromatic ketone metabolite of naphthalene." [] subset: 3_STAR synonym: "naphthoquinones" RELATED [ChEBI] is_a: CHEBI:36141 ! quinone [Term] id: CHEBI:25491 name: nematicide namespace: chebi_ontology def: "A substance used to destroy pests of the phylum Nematoda (roundworms)." [] subset: 3_STAR synonym: "nematicides" RELATED [ChEBI] synonym: "nematocide" RELATED [ChEBI] synonym: "nematocides" RELATED [ChEBI] xref: Wikipedia:Nematicide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:25512 name: neurotransmitter namespace: chebi_ontology def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." [] subset: 3_STAR synonym: "neurotransmitters" RELATED [ChEBI] xref: Wikipedia:Neurotransmitter is_a: CHEBI:33280 ! molecular messenger [Term] id: CHEBI:25529 name: pyridinecarboxamide namespace: chebi_ontology def: "A member of the class of pyridines that is a substituted pyridine in which at least one of the substituents is a carboxamide or N-substituted caraboxamide group." [] subset: 3_STAR synonym: "pyridinecarboxamides" RELATED [ChEBI] is_a: CHEBI:26421 ! pyridines is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:25555 name: nitrogen atom namespace: chebi_ontology subset: 3_STAR synonym: "7N" RELATED [IUPAC] synonym: "azote" RELATED [IUPAC] synonym: "N" RELATED [IUPAC] synonym: "nitrogen" EXACT IUPAC_NAME [IUPAC] synonym: "nitrogen" RELATED [ChEBI] synonym: "nitrogeno" RELATED [ChEBI] synonym: "Stickstoff" RELATED [ChEBI] xref: WebElements:N is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "14.007" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string [Term] id: CHEBI:25558 name: organonitrogen heterocyclic antibiotic namespace: chebi_ontology subset: 3_STAR synonym: "organonitrogen heterocyclic antibiotics" RELATED [ChEBI] is_a: CHEBI:24531 ! heterocyclic antibiotic is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:25585 name: nonmetal atom namespace: chebi_ontology subset: 3_STAR synonym: "Nichtmetall" RELATED [ChEBI] synonym: "Nichtmetalle" RELATED [ChEBI] synonym: "no metal" RELATED [ChEBI] synonym: "no metales" RELATED [ChEBI] synonym: "non-metal" RELATED [ChEBI] synonym: "non-metaux" RELATED [ChEBI] synonym: "nonmetal" EXACT IUPAC_NAME [IUPAC] synonym: "nonmetal" RELATED [ChEBI] synonym: "nonmetals" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:25605 name: nucleoside antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:25608 name: nucleoside phosphate namespace: chebi_ontology def: "A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates." [] subset: 3_STAR synonym: "NMP" RELATED [KEGG_COMPOUND] synonym: "Nucleoside monophosphate" RELATED [KEGG_COMPOUND] synonym: "nucleoside phosphates" RELATED [ChEBI] xref: KEGG:C01329 is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester is_a: CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_functional_parent CHEBI:33838 ! nucleoside [Term] id: CHEBI:25675 name: oligomycin namespace: chebi_ontology def: "Any of the 26-membered ring macrolides produced by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases." [] subset: 3_STAR synonym: "oligomycins" RELATED [ChEBI] xref: Wikipedia:Oligomycin is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:72600 ! spiroketal relationship: RO:0000087 CHEBI:20854 ! has role ATP synthase inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C43H64O10R5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "740.964" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "740.44995" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H]1([C@H](CC([C@]2(O1)C([C@@H]3OC(C=C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C([C@@]([C@@H](O)[C@H](C)CC=CC=C[C@@H](CC[C@@H]([C@H]3C)O2)CC)(*)C)=O)=O)(*)*)=*)C)C[C@H](O)*" xsd:string [Term] id: CHEBI:25676 name: oligopeptide namespace: chebi_ontology alt_id: CHEBI:7755 def: "A peptide containing a relatively small number of amino acids." [] subset: 3_STAR synonym: "Oligopeptid" RELATED [ChEBI] synonym: "oligopeptides" EXACT IUPAC_NAME [IUPAC] synonym: "oligopeptido" RELATED [ChEBI] xref: Wikipedia:Oligopeptide is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:25693 name: organic heteromonocyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic heteromonocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33670 ! heteromonocyclic compound [Term] id: CHEBI:25696 name: organic anion namespace: chebi_ontology def: "Any organic ion with a net negative charge." [] subset: 3_STAR synonym: "organic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:25699 ! organic ion [Term] id: CHEBI:25697 name: organic cation namespace: chebi_ontology def: "Any organic ion with a net positive charge." [] subset: 3_STAR synonym: "organic cations" RELATED [ChEBI] is_a: CHEBI:25699 ! organic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:25698 name: ether namespace: chebi_ontology def: "An organooxygen compound with formula ROR, where R is not hydrogen." [] subset: 3_STAR synonym: "ether" EXACT IUPAC_NAME [IUPAC] synonym: "ethers" EXACT IUPAC_NAME [IUPAC] synonym: "ethers" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "OR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]O[*]" xsd:string [Term] id: CHEBI:25699 name: organic ion namespace: chebi_ontology subset: 3_STAR synonym: "organic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:25703 name: organic phosphate namespace: chebi_ontology subset: 3_STAR synonym: "organic phosphate" EXACT [ChEBI] synonym: "organic phosphate ester" RELATED [ChEBI] synonym: "organic phosphate esters" RELATED [ChEBI] synonym: "organic phosphates" RELATED [ChEBI] synonym: "organophosphate ester" RELATED [ChEBI] synonym: "organophosphate esters" RELATED [ChEBI] xref: Wikipedia:Organophosphate is_a: CHEBI:25710 ! organophosphorus compound is_a: CHEBI:26020 ! phosphate [Term] id: CHEBI:25704 name: organic sulfate namespace: chebi_ontology def: "Compounds of the general formula SO3HOR where R is an organyl group" [] subset: 3_STAR synonym: "organic sulfates" RELATED [ChEBI] is_a: CHEBI:26820 ! sulfates relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion [Term] id: CHEBI:2571 name: aliphatic alcohol namespace: chebi_ontology def: "An alcohol derived from an aliphatic compound." [] subset: 3_STAR synonym: "Aliphatic alcohol" EXACT [KEGG_COMPOUND] synonym: "aliphatic alcohols" RELATED [ChEBI] synonym: "an aliphatic alcohol" RELATED [UniProt] xref: KEGG:C02525 is_a: CHEBI:30879 ! alcohol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HOR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "17.007" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O*" xsd:string [Term] id: CHEBI:25710 name: organophosphorus compound namespace: chebi_ontology def: "An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters." [] subset: 3_STAR synonym: "organophosphorus compound" EXACT [ChEBI] synonym: "organophosphorus compounds" RELATED [ChEBI] xref: Wikipedia:Organophosphorus_compound is_a: CHEBI:26082 ! phosphorus molecular entity is_a: CHEBI:33285 ! heteroorganic entity [Term] id: CHEBI:25728 name: osmolyte namespace: chebi_ontology def: "A solute used by a cell under water stress to maintain cell volume." [] subset: 3_STAR synonym: "osmolytes" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:25741 name: oxide namespace: chebi_ontology def: "An oxide is a chemical compound of oxygen with other chemical elements." [] subset: 3_STAR synonym: "oxide" EXACT [ChEBI] synonym: "oxides" RELATED [ChEBI] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:25750 name: oxime namespace: chebi_ontology def: "Compounds of structure R2C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes." [] subset: 3_STAR synonym: "oxime" EXACT [IUPAC] synonym: "oximes" EXACT IUPAC_NAME [IUPAC] synonym: "oximes" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity is_a: CHEBI:51143 ! nitrogen molecular entity relationship: is_conjugate_acid_of CHEBI:142513 ! oxime anion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNOR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "43.02470" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.00581" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O\\N=C(\\[*])[*]" xsd:string [Term] id: CHEBI:25754 name: oxo carboxylic acid namespace: chebi_ontology def: "Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule." [] subset: 3_STAR synonym: "oxo acids" RELATED [IUPAC] synonym: "oxo carboxylic acids" EXACT IUPAC_NAME [IUPAC] synonym: "oxo carboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35903 ! oxo carboxylic acid anion [Term] id: CHEBI:2580 name: unsaturated fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion containing at least one C-C unsaturated bond; formed by deprotonation of the carboxylic acid moiety." [] subset: 3_STAR is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:27208 ! unsaturated fatty acid [Term] id: CHEBI:25805 name: oxygen atom namespace: chebi_ontology subset: 3_STAR synonym: "8O" RELATED [IUPAC] synonym: "O" RELATED [IUPAC] synonym: "oxigeno" RELATED [ChEBI] synonym: "oxygen" EXACT IUPAC_NAME [IUPAC] synonym: "oxygen" RELATED [ChEBI] synonym: "oxygene" RELATED [ChEBI] synonym: "Sauerstoff" RELATED [ChEBI] xref: KEGG:C00007 xref: WebElements:O is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QVGXLLKOCUKJST-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O]" xsd:string [Term] id: CHEBI:25806 name: oxygen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "oxygen molecular entities" RELATED [ChEBI] synonym: "oxygen molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:25805 ! oxygen atom [Term] id: CHEBI:25807 name: organooxygen heterocyclic antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24531 ! heterocyclic antibiotic [Term] id: CHEBI:25830 name: p-quinones namespace: chebi_ontology def: "A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring." [] subset: 3_STAR synonym: "p-quinone" RELATED [ChEBI] synonym: "para-quinones" RELATED [ChEBI] is_a: CHEBI:36141 ! quinone [Term] id: CHEBI:25865 name: penicillanic acids namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:35992 ! penams [Term] id: CHEBI:25900 name: aldopentose phosphate namespace: chebi_ontology subset: 3_STAR synonym: "aldopentose phosphate" EXACT [ChEBI] synonym: "aldopentose phosphates" RELATED [ChEBI] is_a: CHEBI:35131 ! aldose phosphate is_a: CHEBI:84055 ! pentose phosphate [Term] id: CHEBI:25901 name: pentose namespace: chebi_ontology def: "A five-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldopentose) or a ketone group at position 2 (ketopentose)." [] subset: 3_STAR synonym: "pentose" EXACT [ChEBI] synonym: "pentoses" RELATED [ChEBI] is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:25903 name: peptide antibiotic namespace: chebi_ontology def: "A chemically diverse class of peptides that exhibit antimicrobial properties." [] subset: 3_STAR synonym: "peptide antibiotics" RELATED [ChEBI] xref: MetaCyc:Peptide-Antibiotics xref: PMID:33398258 {source="Europe PMC"} is_a: CHEBI:16670 ! peptide relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:25940 name: peroxides namespace: chebi_ontology def: "Compounds of structure ROOR'." [] subset: 3_STAR synonym: "a peroxide" RELATED [UniProt] is_a: CHEBI:25741 ! oxide relationship: has_part CHEBI:29369 ! peroxy group relationship: RO:0000087 CHEBI:63248 ! has role oxidising agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "31.999" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]OO[*]" xsd:string [Term] id: CHEBI:25944 name: pesticide namespace: chebi_ontology def: "Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests." [] subset: 3_STAR synonym: "pesticide" EXACT IUPAC_NAME [IUPAC] synonym: "pesticides" RELATED [ChEBI] synonym: "Pestizid" RELATED [ChEBI] synonym: "Pestizide" RELATED [ChEBI] xref: Wikipedia:Pesticide is_a: CHEBI:33232 ! application [Term] id: CHEBI:26004 name: phenylpropanoid namespace: chebi_ontology def: "Any organic aromatic compound with a structure based on a phenylpropane skeleton. The class includes naturally occurring phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules as well as their semi-synthetic and synthetic analogues. Phenylpropanoids are also precursors of lignin." [] subset: 3_STAR synonym: "phenylpropanoids" RELATED [ChEBI] xref: Wikipedia:Phenylpropanoid is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:26020 name: phosphate namespace: chebi_ontology def: "Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom." [] subset: 3_STAR synonym: "phosphates" EXACT IUPAC_NAME [IUPAC] synonym: "phosphates" RELATED [ChEBI] is_a: CHEBI:26079 ! phosphoric acid derivative [Term] id: CHEBI:26045 name: phosphite ion namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33461 ! phosphorus oxoanion [Term] id: CHEBI:26069 name: phosphonic acids namespace: chebi_ontology def: "HP(=O)(OH)2 (phosphonic acid) and its P-substituted derivatives." [] subset: 3_STAR synonym: "phosphonic acids" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives [Term] id: CHEBI:26078 name: phosphoric acid namespace: chebi_ontology def: "A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom." [] subset: 3_STAR synonym: "[PO(OH)3]" RELATED [IUPAC] synonym: "acide phosphorique" RELATED [ChEBI] synonym: "acidum phosphoricum" RELATED [ChEBI] synonym: "H3PO4" RELATED [IUPAC] synonym: "Orthophosphoric acid" RELATED [KEGG_COMPOUND] synonym: "orthophosphoric acid" RELATED [NIST_Chemistry_WebBook] synonym: "Phosphate" RELATED [KEGG_COMPOUND] synonym: "Phosphoric acid" EXACT [KEGG_COMPOUND] synonym: "phosphoric acid" EXACT [IUPAC] synonym: "Phosphorsaeure" RELATED [ChEBI] synonym: "Phosphorsaeureloesungen" RELATED [ChEBI] synonym: "tetraoxophosphoric acid" EXACT IUPAC_NAME [IUPAC] synonym: "trihydrogen tetraoxophosphate(3-)" EXACT IUPAC_NAME [IUPAC] synonym: "trihydroxidooxidophosphorus" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:1921286 {source="Beilstein"} xref: CAS:7664-38-2 {source="NIST Chemistry WebBook"} xref: CAS:7664-38-2 {source="KEGG COMPOUND"} xref: CAS:7664-38-2 {source="ChemIDplus"} xref: Drug_Central:4478 {source="DrugCentral"} xref: Gmelin:2000 {source="Gmelin"} xref: HMDB:HMDB0002142 xref: KEGG:C00009 xref: KEGG:D05467 xref: KNApSAcK:C00007408 xref: PMID:11455380 {source="Europe PMC"} xref: PMID:15630224 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17518491 {source="Europe PMC"} xref: PMID:22282755 {source="Europe PMC"} xref: PMID:22333268 {source="Europe PMC"} xref: PMID:22381614 {source="Europe PMC"} xref: PMID:22401268 {source="Europe PMC"} xref: Reaxys:1921286 {source="Reaxys"} xref: Wikipedia:Phosphoric_Acid is_a: CHEBI:59698 ! phosphoric acids relationship: is_conjugate_acid_of CHEBI:39745 ! dihydrogenphosphate relationship: RO:0000087 CHEBI:33287 ! has role fertilizer relationship: RO:0000087 CHEBI:46787 ! has role solvent relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H3O4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "97.99520" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "97.97690" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP(=O)(O[H])O[H]" xsd:string [Term] id: CHEBI:26079 name: phosphoric acid derivative namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:36359 ! phosphorus oxoacid derivative relationship: has_functional_parent CHEBI:26078 ! phosphoric acid [Term] id: CHEBI:26082 name: phosphorus molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "phosphorus molecular entities" RELATED [ChEBI] is_a: CHEBI:33302 ! pnictogen molecular entity relationship: has_part CHEBI:28659 ! phosphorus atom [Term] id: CHEBI:26094 name: benzenedicarboxylic acid namespace: chebi_ontology def: "A member of the class of benzoic acids in that consists of benzene substituted by two carboxy groups (A closed class)." [] subset: 3_STAR synonym: "benzenedicarboxylic acid" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:22723 ! benzoic acids is_a: CHEBI:35692 ! dicarboxylic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "166.131" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.02661" xsd:string [Term] id: CHEBI:26115 name: phytoalexin namespace: chebi_ontology def: "A toxin made by a plant that acts against an organism attacking it." [] subset: 3_STAR synonym: "phytoalexins" RELATED [ChEBI] is_a: CHEBI:38231 ! phytotoxin [Term] id: CHEBI:26130 name: biological pigment namespace: chebi_ontology def: "An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light." [] subset: 3_STAR synonym: "pigments" RELATED [ChEBI] is_a: CHEBI:52208 ! biophysical role [Term] id: CHEBI:26144 name: piperazines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26151 name: piperidines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26155 name: plant growth regulator namespace: chebi_ontology def: "A chemical, natural or artificial, that can affect the rate of growth of a plant." [] subset: 3_STAR synonym: "plant growth regulators" RELATED [ChEBI] is_a: CHEBI:39317 ! growth regulator [Term] id: CHEBI:26167 name: polar amino acid namespace: chebi_ontology alt_id: CHEBI:8283 def: "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." [] subset: 3_STAR synonym: "polar amino acid" EXACT [ChEBI] synonym: "polar amino acids" RELATED [ChEBI] synonym: "polar amino-acid" RELATED [ChEBI] synonym: "polar amino-acids" RELATED [ChEBI] xref: MetaCyc:Polar-amino-acids xref: PMID:12016058 {source="Europe PMC"} is_a: CHEBI:33709 ! amino acid relationship: is_tautomer_of CHEBI:62031 ! polar amino acid zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(C(*)N)=O" xsd:string [Term] id: CHEBI:26177 name: polyene antibiotic namespace: chebi_ontology def: "A family of antibiotics containing a conjugated polyene moiety, usuallly isolated from some species of Streptomyces." [] subset: 3_STAR synonym: "polyene antibiotics" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:26188 name: polyketide namespace: chebi_ontology def: "Natural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides." [] subset: 3_STAR synonym: "polyketide" EXACT [ChEBI] synonym: "polyketides" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:26191 name: polyol namespace: chebi_ontology def: "A compound that contains two or more hydroxy groups." [] subset: 3_STAR synonym: "polyols" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:26195 name: polyphenol namespace: chebi_ontology def: "Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group." [] subset: 3_STAR synonym: "polyphenols" RELATED [ChEBI] xref: Wikipedia:Polyphenol is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:26199 name: polyprenol namespace: chebi_ontology alt_id: CHEBI:8317 def: "Any member of the class of prenols possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of more than one isoprene units." [] subset: 3_STAR synonym: "polyprenols" RELATED [ChEBI] xref: KEGG:C06081 is_a: CHEBI:26244 ! prenols property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(C5H8)nC10H18O" xsd:string [Term] id: CHEBI:26208 name: polyunsaturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome." [] subset: 3_STAR synonym: "polyunsaturated fatty acids" RELATED [ChEBI] synonym: "PUFA" RELATED [ChEBI] synonym: "PUFAs" RELATED [ChEBI] xref: PMID:14977874 {source="Europe PMC"} xref: PMID:16380690 {source="Europe PMC"} xref: PMID:17891522 {source="Europe PMC"} is_a: CHEBI:27208 ! unsaturated fatty acid relationship: is_conjugate_acid_of CHEBI:76567 ! polyunsaturated fatty acid anion [Term] id: CHEBI:26216 name: potassium atom namespace: chebi_ontology subset: 3_STAR synonym: "19K" RELATED [IUPAC] synonym: "K" RELATED [IUPAC] synonym: "Kalium" RELATED [ChemIDplus] synonym: "kalium" RELATED [IUPAC] synonym: "potasio" RELATED [ChEBI] synonym: "potassium" EXACT IUPAC_NAME [IUPAC] synonym: "potassium" RELATED [ChEBI] xref: CAS:7440-09-7 {source="ChemIDplus"} xref: DrugBank:DB01345 xref: KEGG:C00238 xref: WebElements:K is_a: CHEBI:22314 ! alkali metal atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "K" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/K" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZLMJMSJWJFRBEC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "39.09830" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "38.96371" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[K]" xsd:string [Term] id: CHEBI:26217 name: potassium molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "potassium molecular entities" RELATED [ChEBI] synonym: "potassium molecular entity" EXACT [ChEBI] is_a: CHEBI:33296 ! alkali metal molecular entity relationship: has_part CHEBI:26216 ! potassium atom [Term] id: CHEBI:26218 name: potassium salt namespace: chebi_ontology def: "Any alkali metal salt having potassium(1+) as the cation." [] subset: 3_STAR synonym: "Kaliumsalz" RELATED [ChEBI] synonym: "Kaliumsalze" RELATED [ChEBI] synonym: "potassium salts" RELATED [ChEBI] is_a: CHEBI:26217 ! potassium molecular entity is_a: CHEBI:35479 ! alkali metal salt relationship: has_part CHEBI:29103 ! potassium(1+) [Term] id: CHEBI:26244 name: prenols namespace: chebi_ontology def: "Any alcohol possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of one or more isoprene units (biogenetic precursors of the isoprenoids)." [] subset: 3_STAR synonym: "prenols" EXACT IUPAC_NAME [IUPAC] xref: PMID:3113948 {source="Europe PMC"} xref: PMID:4207873 {source="Europe PMC"} is_a: CHEBI:24913 ! isoprenoid is_a: CHEBI:30879 ! alcohol [Term] id: CHEBI:26271 name: proline namespace: chebi_ontology def: "An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2." [] subset: 3_STAR synonym: "DL-Proline" RELATED [KEGG_COMPOUND] synonym: "Hpro" RELATED [IUPAC] synonym: "Prolin" RELATED [ChEBI] synonym: "prolina" RELATED [ChEBI] synonym: "proline" EXACT [ChEBI] synonym: "proline" EXACT IUPAC_NAME [IUPAC] synonym: "pyrrolidine-2-carboxylic acid" RELATED [IUPAC] xref: Beilstein:80809 {source="Beilstein"} xref: CAS:609-36-9 {source="KEGG COMPOUND"} xref: CAS:609-36-9 {source="NIST Chemistry WebBook"} xref: CAS:609-36-9 {source="ChemIDplus"} xref: Gmelin:26927 {source="Gmelin"} xref: KEGG:C16435 xref: PMID:16534801 {source="Europe PMC"} xref: PMID:21400017 {source="Europe PMC"} xref: PMID:21903295 {source="Europe PMC"} xref: PMID:22264337 {source="Europe PMC"} xref: PMID:22280966 {source="Europe PMC"} xref: PMID:22770225 {source="Europe PMC"} xref: Reaxys:80809 {source="Reaxys"} xref: Wikipedia:Proline is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:38260 ! pyrrolidines relationship: is_conjugate_acid_of CHEBI:32871 ! prolinate relationship: is_conjugate_base_of CHEBI:32872 ! prolinium relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "115.13050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "115.06333" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)C1CCCN1" xsd:string [Term] id: CHEBI:26273 name: proline derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of proline by a heteroatom. The definition normally excludes peptides containing proline residues." [] subset: 3_STAR synonym: "proline derivatives" RELATED [ChEBI] is_a: CHEBI:83821 ! amino acid derivative relationship: has_functional_parent CHEBI:26271 ! proline [Term] id: CHEBI:2634 name: amidine namespace: chebi_ontology def: "Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine." [] subset: 3_STAR synonym: "amidine" EXACT [IUPAC] synonym: "Amidines" RELATED [KEGG_COMPOUND] synonym: "amidines" EXACT IUPAC_NAME [IUPAC] synonym: "amidines" RELATED [ChEBI] is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:2637 name: amikacin namespace: chebi_ontology def: "An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group." [] subset: 3_STAR synonym: "(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide" EXACT IUPAC_NAME [IUPAC] synonym: "1-N-(L(-)-gamma-amino-alpha-hydroxybutyryl)kanamycin A" RELATED [ChemIDplus] synonym: "Amikacin" EXACT [KEGG_COMPOUND] synonym: "amikacin" RELATED INN [ChemIDplus] synonym: "amikacina" RELATED INN [ChemIDplus] synonym: "amikacine" RELATED INN [ChemIDplus] synonym: "amikacinum" RELATED INN [ChemIDplus] synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine" RELATED [ChemIDplus] xref: Beilstein:5915117 {source="Beilstein"} xref: CAS:37517-28-5 {source="ChemIDplus"} xref: CAS:37517-28-5 {source="KEGG COMPOUND"} xref: Drug_Central:157 {source="DrugCentral"} xref: DrugBank:DB00479 xref: HMDB:HMDB0014622 xref: KEGG:C06820 xref: KEGG:D02543 xref: LINCS:LSM-5935 xref: MetaCyc:CPD-14197 xref: Patent:DE2234315 xref: Patent:US3781268 xref: PMID:11744283 {source="Europe PMC"} xref: PMID:15305513 {source="Europe PMC"} xref: PMID:17365906 {source="Europe PMC"} xref: PMID:19495517 {source="Europe PMC"} xref: PMID:19752274 {source="Europe PMC"} xref: PMID:20195673 {source="Europe PMC"} xref: PMID:25296102 {source="Europe PMC"} xref: PMID:25327505 {source="Europe PMC"} xref: PMID:25339395 {source="Europe PMC"} xref: PMID:25630642 {source="Europe PMC"} xref: PMID:8622103 {source="Europe PMC"} xref: PMID:8622117 {source="Europe PMC"} xref: PMID:9327246 {source="Europe PMC"} xref: Reaxys:5915117 {source="Reaxys"} xref: Wikipedia:Amikacin is_a: CHEBI:22390 ! alpha-D-glucoside is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:47779 ! aminoglycoside relationship: has_functional_parent CHEBI:17630 ! kanamycin A relationship: is_conjugate_base_of CHEBI:84739 ! amikacin(4+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:61015 ! has role nephrotoxin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H43N5O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LKCWBDHBTVXHDL-RMDFUYIESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "585.60272" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "585.28574" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O" xsd:string [Term] id: CHEBI:26395 name: purine nucleotide namespace: chebi_ontology def: "Any nucleotide that has a purine nucleobase." [] subset: 3_STAR synonym: "purine nucleotides" RELATED [ChEBI] is_a: CHEBI:26401 ! purines is_a: CHEBI:36976 ! nucleotide [Term] id: CHEBI:26400 name: purine ribonucleotide namespace: chebi_ontology def: "Any ribonucleotide that has a purine nucleobase." [] subset: 3_STAR synonym: "purine ribonucleotides" RELATED [ChEBI] is_a: CHEBI:26395 ! purine nucleotide is_a: CHEBI:26561 ! ribonucleotide [Term] id: CHEBI:26401 name: purines namespace: chebi_ontology alt_id: CHEBI:13678 def: "A class of imidazopyrimidines that consists of purine and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:35875 ! imidazopyrimidine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5N4R7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "116.080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.01230" xsd:string [Term] id: CHEBI:26416 name: pyridine alkaloid namespace: chebi_ontology subset: 3_STAR synonym: "pyridine alkaloids" RELATED [ChEBI] is_a: CHEBI:22315 ! alkaloid is_a: CHEBI:26421 ! pyridines [Term] id: CHEBI:26420 name: pyridinemonocarboxylic acid namespace: chebi_ontology def: "A monocarboxylic acid in which the carboxy group is attached to a pyridine (or substituted pyridine) ring." [] subset: 3_STAR synonym: "pyridinemonocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:26421 ! pyridines is_a: CHEBI:33859 ! aromatic carboxylic acid relationship: is_conjugate_acid_of CHEBI:38181 ! pyridinemonocarboxylate [Term] id: CHEBI:26421 name: pyridines namespace: chebi_ontology def: "Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26432 name: pyrimidine nucleobase namespace: chebi_ontology def: "A nucleobase whose skeleton is derived from pyrimidine." [] subset: 3_STAR synonym: "a pyrimidine nucleobase" RELATED [UniProt] synonym: "pyrimidine bases" RELATED [ChEBI] synonym: "pyrimidine nucleobase" EXACT [ChEBI] synonym: "pyrimidine nucleobases" RELATED [ChEBI] is_a: CHEBI:18282 ! nucleobase is_a: CHEBI:39447 ! pyrimidines property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4HN2R4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "77.064" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "77.01397" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N1C(=C(C(=NC1=*)*)*)*" xsd:string [Term] id: CHEBI:26440 name: pyrimidine nucleoside namespace: chebi_ontology subset: 3_STAR synonym: "N-D-Ribosylpyrimidine" RELATED [KEGG_COMPOUND] synonym: "pyrimidine nucleosides" RELATED [ChEBI] xref: KEGG:C03169 is_a: CHEBI:33838 ! nucleoside is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:26455 name: pyrroles namespace: chebi_ontology def: "An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton." [] subset: 3_STAR is_a: CHEBI:68452 ! azole [Term] id: CHEBI:26469 name: quaternary nitrogen compound namespace: chebi_ontology def: "A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen." [] subset: 3_STAR is_a: CHEBI:35352 ! organonitrogen compound relationship: has_part CHEBI:35267 ! quaternary ammonium ion [Term] id: CHEBI:26509 name: quinoline alkaloid namespace: chebi_ontology subset: 3_STAR synonym: "quinoline alkaloids" RELATED [ChEBI] is_a: CHEBI:22315 ! alkaloid [Term] id: CHEBI:26512 name: quinolinemonocarboxylic acid namespace: chebi_ontology def: "Any aromatic carboxylic acid that contains a quinoline moiety that is substituted by one carboxy substituent." [] subset: 3_STAR synonym: "quinolinemonocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:26513 ! quinolines is_a: CHEBI:33859 ! aromatic carboxylic acid relationship: is_conjugate_acid_of CHEBI:38773 ! quinolinemonocarboxylate [Term] id: CHEBI:26513 name: quinolines namespace: chebi_ontology def: "A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring." [] subset: 3_STAR is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26523 name: reactive oxygen species namespace: chebi_ontology def: "Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [] subset: 3_STAR synonym: "ROS" RELATED [ChEBI] xref: Wikipedia:Reactive_oxygen_species is_a: CHEBI:25806 ! oxygen molecular entity [Term] id: CHEBI:26561 name: ribonucleotide namespace: chebi_ontology subset: 3_STAR synonym: "ribonucleotides" RELATED [ChEBI] is_a: CHEBI:26562 ! ribose phosphate is_a: CHEBI:36976 ! nucleotide [Term] id: CHEBI:26562 name: ribose phosphate namespace: chebi_ontology subset: 3_STAR synonym: "ribose phosphate" EXACT [ChEBI] synonym: "ribose phosphates" RELATED [ChEBI] is_a: CHEBI:25900 ! aldopentose phosphate [Term] id: CHEBI:26580 name: rifamycins namespace: chebi_ontology subset: 3_STAR synonym: "rifamycin" RELATED [ChEBI] xref: Wikipedia:Rifamycin is_a: CHEBI:22565 ! ansamycin is_a: CHEBI:39270 ! naphthofuran [Term] id: CHEBI:26588 name: 1,3,5-triazines namespace: chebi_ontology def: "Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure." [] subset: 3_STAR synonym: "s-triazines" RELATED [ChEBI] is_a: CHEBI:38102 ! triazines [Term] id: CHEBI:26607 name: saturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess." [] subset: 3_STAR synonym: "saturated fatty acid" EXACT [ChEBI] synonym: "saturated fatty acids" RELATED [ChEBI] synonym: "SFA" RELATED [ChEBI] synonym: "SFAs" RELATED [ChEBI] xref: PMID:16492686 {source="Europe PMC"} xref: PMID:19763019 {source="Europe PMC"} xref: PMID:20237329 {source="Europe PMC"} is_a: CHEBI:35366 ! fatty acid [Term] id: CHEBI:26649 name: serine derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of serine by a heteroatom. The definition normally excludes peptides containing serine residues." [] subset: 3_STAR synonym: "serine derivatives" RELATED [ChEBI] is_a: CHEBI:83821 ! amino acid derivative relationship: has_functional_parent CHEBI:17822 ! serine [Term] id: CHEBI:26658 name: sesquiterpenoid namespace: chebi_ontology def: "Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." [] subset: 3_STAR synonym: "sesquiterpenoides" RELATED [ChEBI] synonym: "sesquiterpenoids" RELATED [ChEBI] xref: LIPID_MAPS_class:LMPR0103 {source="LIPID MAPS"} is_a: CHEBI:26873 ! terpenoid relationship: has_parent_hydride CHEBI:35189 ! sesquiterpene [Term] id: CHEBI:26666 name: short-chain fatty acid namespace: chebi_ontology def: "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." [] subset: 3_STAR synonym: "SCFA" RELATED [ChEBI] synonym: "SCFAs" RELATED [ChEBI] synonym: "short-chain fatty acids" RELATED [ChEBI] xref: PMID:16633129 {source="Europe PMC"} xref: PMID:16870803 {source="Europe PMC"} xref: PMID:18203540 {source="Europe PMC"} xref: PMID:20148677 {source="Europe PMC"} is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:58951 ! short-chain fatty acid anion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2OR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "45.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string [Term] id: CHEBI:26708 name: sodium atom namespace: chebi_ontology subset: 3_STAR synonym: "11Na" RELATED [IUPAC] synonym: "Na" RELATED [IUPAC] synonym: "Natrium" RELATED [ChemIDplus] synonym: "natrium" RELATED [IUPAC] synonym: "sodio" RELATED [ChemIDplus] synonym: "sodium" EXACT IUPAC_NAME [IUPAC] synonym: "sodium" RELATED [ChEBI] xref: CAS:7440-23-5 {source="ChemIDplus"} xref: Gmelin:16221 {source="Gmelin"} xref: KEGG:C01330 xref: WebElements:Na is_a: CHEBI:22314 ! alkali metal atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Na" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Na" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KEAYESYHFKHZAL-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "22.98977" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "22.98977" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na]" xsd:string [Term] id: CHEBI:26710 name: sodium chloride namespace: chebi_ontology def: "An inorganic chloride salt having sodium(1+) as the counterion." [] subset: 3_STAR synonym: "chlorure de sodium" RELATED [ChEBI] synonym: "cloruro sodico" RELATED [ChEBI] synonym: "common salt" RELATED [ChemIDplus] synonym: "halite" RELATED [NIST_Chemistry_WebBook] synonym: "Kochsalz" RELATED [ChEBI] synonym: "NaCl" RELATED [IUPAC] synonym: "natrii chloridum" RELATED [ChEBI] synonym: "Natriumchlorid" RELATED [NIST_Chemistry_WebBook] synonym: "rock salt" RELATED [ChemIDplus] synonym: "salt" RELATED [ChemIDplus] synonym: "sodium chloride" EXACT [ChEBI] synonym: "sodium chloride" EXACT IUPAC_NAME [IUPAC] synonym: "table salt" RELATED [ChemIDplus] xref: Beilstein:3534976 {source="Beilstein"} xref: CAS:7647-14-5 {source="ChemIDplus"} xref: CAS:7647-14-5 {source="NIST Chemistry WebBook"} xref: CAS:7647-14-5 {source="KEGG COMPOUND"} xref: Gmelin:13673 {source="Gmelin"} xref: KEGG:C13563 xref: KEGG:D02056 xref: MetaCyc:NACL xref: PPDB:595 xref: Reaxys:3534976 {source="Reaxys"} xref: Wikipedia:Sodium_Chloride is_a: CHEBI:36093 ! inorganic chloride is_a: CHEBI:38702 ! inorganic sodium salt relationship: RO:0000087 CHEBI:149552 ! has role emetic relationship: RO:0000087 CHEBI:79314 ! has role flame retardant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "ClNa" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH.Na/h1H;/q;+1/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FAPWRFPIFSIZLT-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "58.44247" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "57.95862" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na+].[Cl-]" xsd:string [Term] id: CHEBI:26712 name: sodium molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sodium compounds" RELATED [ChEBI] synonym: "sodium molecular entities" RELATED [ChEBI] is_a: CHEBI:33296 ! alkali metal molecular entity relationship: has_part CHEBI:26708 ! sodium atom [Term] id: CHEBI:26714 name: sodium salt namespace: chebi_ontology def: "Any alkali metal salt having sodium(1+) as the cation." [] subset: 3_STAR synonym: "Natriumsalz" RELATED [ChEBI] synonym: "Natriumsalze" RELATED [ChEBI] synonym: "sodium salts" RELATED [ChEBI] is_a: CHEBI:26712 ! sodium molecular entity is_a: CHEBI:35479 ! alkali metal salt relationship: has_part CHEBI:29101 ! sodium(1+) [Term] id: CHEBI:26739 name: sphingolipid namespace: chebi_ontology def: "Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone." [] subset: 3_STAR synonym: "sphingolipids" RELATED [ChEBI] is_a: CHEBI:18059 ! lipid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:2676 name: amoxicillin namespace: chebi_ontology alt_id: CHEBI:133770 def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid" RELATED [ChemIDplus] synonym: "6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-amino-p-hydroxybenzylpenicillin" RELATED [ChemIDplus] synonym: "Amolin" RELATED BRAND_NAME [DrugBank] synonym: "Amopenixin" RELATED BRAND_NAME [DrugBank] synonym: "amoxicilina" RELATED INN [ChemIDplus] synonym: "Amoxicillin" EXACT [KEGG_COMPOUND] synonym: "amoxicillin" RELATED INN [KEGG_DRUG] synonym: "Amoxicillin anhydrous" RELATED [KEGG_COMPOUND] synonym: "amoxicilline" RELATED INN [ChemIDplus] synonym: "amoxicillinum" RELATED INN [ChemIDplus] synonym: "amoxycilin" RELATED [ChEBI] synonym: "amoxycillin" RELATED [ChemIDplus] synonym: "AMPC" RELATED BRAND_NAME [DrugBank] synonym: "AX" RELATED [ChEBI] synonym: "Clamoxyl" RELATED BRAND_NAME [ChemIDplus] synonym: "Moxal" RELATED BRAND_NAME [DrugBank] synonym: "p-hydroxyampicillin" RELATED [ChemIDplus] xref: Beilstein:4274654 {source="Beilstein"} xref: CAS:26787-78-0 {source="ChemIDplus"} xref: CAS:26787-78-0 {source="KEGG COMPOUND"} xref: Drug_Central:192 {source="DrugCentral"} xref: DrugBank:DB01060 xref: HMDB:HMDB0015193 xref: KEGG:C06827 xref: KEGG:D07452 xref: LINCS:LSM-5654 xref: Patent:DE1942693 xref: Patent:GB1241844 xref: Patent:GB978178 xref: Patent:US3192198 xref: PMID:10930630 {source="Europe PMC"} xref: PMID:11431418 {source="Europe PMC"} xref: PMID:11906332 {source="Europe PMC"} xref: PMID:12569987 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:12850488 {source="Europe PMC"} xref: PMID:16033609 {source="Europe PMC"} xref: PMID:2083978 {source="Europe PMC"} xref: PMID:24595455 {source="Europe PMC"} xref: PMID:24631718 {source="Europe PMC"} xref: PMID:24759068 {source="Europe PMC"} xref: PMID:25998949 {source="Europe PMC"} xref: PMID:27731424 {source="Europe PMC"} xref: PMID:28987997 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:4274654 {source="Reaxys"} xref: VSDB:1741 xref: Wikipedia:Amoxicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51256 ! amoxicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H19N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSQZJLSUYDQPKJ-NJBDSQKTSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "365.40400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "365.10454" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O" xsd:string [Term] id: CHEBI:26761 name: steroid antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:35341 ! steroid is_a: CHEBI:49319 ! carbocyclic antibiotic [Term] id: CHEBI:26775 name: stilbene namespace: chebi_ontology subset: 3_STAR synonym: "1,1'-(1,2-ethenediyl)bis[benzene]" RELATED [NIST_Chemistry_WebBook] synonym: "1,1'-(1,2-ethenediyl)bisbenzene" RELATED [ChemIDplus] synonym: "1,1'-(1,2-ethenediyl)dibenzene" RELATED [ChemIDplus] synonym: "1,1'-(ethene-1,2-diyl)dibenzene" EXACT IUPAC_NAME [IUPAC] synonym: "1,1'-ethene-1,2-diyldibenzene" RELATED [ChEBI] synonym: "1,2-diphenylethylene" RELATED [NIST_Chemistry_WebBook] synonym: "alpha,beta-diphenylethylene" RELATED [NIST_Chemistry_WebBook] synonym: "stilbene" EXACT [ChemIDplus] xref: Beilstein:1904445 {source="ChemIDplus"} xref: CAS:588-59-0 {source="NIST Chemistry WebBook"} xref: CAS:588-59-0 {source="ChemIDplus"} xref: Gmelin:67845 {source="Gmelin"} xref: Wikipedia:Stilbene is_a: CHEBI:22712 ! benzenes is_a: CHEBI:78840 ! olefinic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H12/c1-3-7-13(8-4-1)11-12-14-9-5-2-6-10-14/h1-12H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJANXHGTPQOBST-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.24508" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.09390" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=C([H])c1ccccc1)c1ccccc1" xsd:string [Term] id: CHEBI:26776 name: stilbenoid namespace: chebi_ontology def: "Any olefinic compound characterised by a 1,2-diphenylethylene backbone." [] subset: 3_STAR synonym: "stilbenes" RELATED [ChEBI] synonym: "stilbenoids" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:26788 name: streptomycins namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:26816 name: carbohydrate phosphate namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate phosphates" RELATED [ChEBI] is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:26819 name: sulfuric ester namespace: chebi_ontology def: "An ester of an alcohol and sulfuric acid." [] subset: 3_STAR synonym: "sulfate ester" RELATED [ChEBI] synonym: "sulfuric acid ester" RELATED [ChEBI] synonym: "sulfuric acid esters" RELATED [ChEBI] is_a: CHEBI:35701 ! ester is_a: CHEBI:37826 ! sulfuric acid derivative property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]OS(=O)(=O)O[*]" xsd:string [Term] id: CHEBI:2682 name: amphotericin B namespace: chebi_ontology alt_id: CHEBI:106303 alt_id: CHEBI:566395 def: "A macrolide antibiotic used to treat potentially life-threatening fungal infections." [] subset: 3_STAR synonym: "(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "amfotericina B" RELATED INN [ChemIDplus] synonym: "AMPH-B" RELATED [DrugBank] synonym: "amphotericin B" RELATED INN [KEGG_DRUG] synonym: "Amphotericine B" RELATED [DrugBank] synonym: "amphotericine B" RELATED INN [ChemIDplus] synonym: "amphotericinum B" RELATED INN [ChemIDplus] synonym: "Liposomal Amphotericin B" RELATED [DrugBank] xref: Beilstein:4645978 {source="Beilstein"} xref: CAS:1397-89-3 {source="ChemIDplus"} xref: CAS:1397-89-3 {source="DrugBank"} xref: CAS:1397-89-3 {source="KEGG COMPOUND"} xref: CAS:1397-89-3 {source="KEGG DRUG"} xref: Drug_Central:197 {source="DrugCentral"} xref: DrugBank:DB00681 xref: KEGG:C06573 xref: KEGG:D00203 xref: LIPID_MAPS_instance:LMPK06000002 {source="LIPID MAPS"} xref: Patent:US2908611 xref: PMID:11429202 {source="Europe PMC"} xref: PMID:11930683 {source="Europe PMC"} xref: PMID:15793154 {source="Europe PMC"} xref: PMID:16120633 {source="Europe PMC"} xref: PMID:16793999 {source="Europe PMC"} xref: PMID:1732516 {source="ChEMBL"} xref: PMID:17507115 {source="ChEMBL"} xref: PMID:33846129 {source="Europe PMC"} xref: Reaxys:4645978 {source="Reaxys"} xref: Wikipedia:Amphotericin_B is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:26177 ! polyene antibiotic is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: RO:0000087 CHEBI:171664 ! has role antiamoebic agent relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C47H73NO17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "APKFDSVGJQXUKY-INPOYWNPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "924.07900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "923.48785" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2" xsd:string [Term] id: CHEBI:26820 name: sulfates namespace: chebi_ontology def: "Salts and esters of sulfuric acid" [] subset: 3_STAR synonym: "sulfates" EXACT [ChEBI] synonym: "sulfuric acid derivative" RELATED [ChEBI] synonym: "sulphates" RELATED [ChEBI] is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26822 name: sulfide namespace: chebi_ontology def: "Any sulfur molecular entity that involves either covalently bonded or anionic sulfur." [] subset: 3_STAR synonym: "sulphides" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:26830 name: sulfonium compound namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:26833 name: sulfur atom namespace: chebi_ontology subset: 3_STAR synonym: "16S" RELATED [IUPAC] synonym: "azufre" RELATED [ChEBI] synonym: "Elemental sulfur" RELATED [KEGG_COMPOUND] synonym: "S" RELATED [KEGG_COMPOUND] synonym: "S" RELATED [IUPAC] synonym: "Schwefel" RELATED [ChEBI] synonym: "soufre" RELATED [ChEBI] synonym: "sulfur" EXACT IUPAC_NAME [IUPAC] synonym: "sulfur" RELATED [ChEBI] synonym: "sulfur" RELATED [UniProt] synonym: "sulphur" RELATED [ChEBI] synonym: "theion" RELATED [IUPAC] xref: CAS:7704-34-9 {source="ChemIDplus"} xref: CAS:7704-34-9 {source="NIST Chemistry WebBook"} xref: KEGG:C00087 xref: KEGG:D06527 xref: PPDB:605 xref: WebElements:S is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NINIDFKCEFEMDL-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "32.06600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97207" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S]" xsd:string [Term] id: CHEBI:26835 name: sulfur molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sulfur molecular entities" RELATED [ChEBI] synonym: "sulfur molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:26833 ! sulfur atom [Term] id: CHEBI:26836 name: sulfuric acid namespace: chebi_ontology def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." [] subset: 3_STAR synonym: "[S(OH)2O2]" RELATED [MolBase] synonym: "[SO2(OH)2]" RELATED [IUPAC] synonym: "Acide sulfurique" RELATED [ChemIDplus] synonym: "Acido sulfurico" RELATED [ChemIDplus] synonym: "Acidum sulfuricum" RELATED [ChemIDplus] synonym: "dihydrogen tetraoxosulfate" EXACT IUPAC_NAME [IUPAC] synonym: "dihydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC] synonym: "H2SO4" RELATED [IUPAC] synonym: "hydrogen tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] synonym: "Schwefelsaeureloesungen" RELATED [ChemIDplus] synonym: "Sulfuric acid" EXACT [KEGG_COMPOUND] synonym: "sulfuric acid" EXACT IUPAC_NAME [IUPAC] synonym: "sulfuric acid" EXACT [ChEBI] synonym: "sulphuric acid" RELATED [MolBase] synonym: "tetraoxosulfuric acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:7664-93-9 {source="ChemIDplus"} xref: CAS:7664-93-9 {source="KEGG COMPOUND"} xref: CAS:7664-93-9 {source="NIST Chemistry WebBook"} xref: Gmelin:2122 {source="Gmelin"} xref: KEGG:C00059 xref: KEGG:D05963 xref: KNApSAcK:C00007530 xref: MolBase:4 xref: PMID:13568755 {source="Europe PMC"} xref: PMID:16122922 {source="Europe PMC"} xref: PMID:19397353 {source="Europe PMC"} xref: PMID:22047659 {source="Europe PMC"} xref: PMID:22136045 {source="Europe PMC"} xref: PMID:22204399 {source="Europe PMC"} xref: PMID:22267186 {source="Europe PMC"} xref: PMID:22296037 {source="Europe PMC"} xref: PMID:22364556 {source="Europe PMC"} xref: PMID:22435616 {source="Europe PMC"} xref: PPDB:606 xref: Reaxys:2037554 {source="Reaxys"} xref: Wikipedia:Sulfuric_acid is_a: CHEBI:33402 ! sulfur oxoacid relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate relationship: RO:0000087 CHEBI:35223 ! has role catalyst property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "98.07948" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "97.96738" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OS(=O)(=O)O[H]" xsd:string [Term] id: CHEBI:26873 name: terpenoid namespace: chebi_ontology def: "Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group." [] subset: 3_STAR synonym: "Terpenoid" EXACT [ChEBI] synonym: "terpenoide" RELATED [IUPAC] synonym: "terpenoides" RELATED [IUPAC] synonym: "terpenoids" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Terpenoid is_a: CHEBI:24913 ! isoprenoid relationship: has_parent_hydride CHEBI:35186 ! terpene [Term] id: CHEBI:26878 name: tertiary alcohol namespace: chebi_ontology def: "A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it." [] subset: 3_STAR synonym: "tertiary alcohol" EXACT [ChEBI] synonym: "tertiary alcohols" RELATED [ChEBI] is_a: CHEBI:30879 ! alcohol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H7OR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "71.09780" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "71.04969" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(C[*])(C[*])C[*]" xsd:string [Term] id: CHEBI:26888 name: tetrachlorobenzene namespace: chebi_ontology def: "Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions." [] subset: 3_STAR synonym: "Tetrachlorbenzol" RELATED [ChEBI] synonym: "tetrachlorobenzene" EXACT IUPAC_NAME [IUPAC] xref: CAS:12408-10-5 {source="ChemIDplus"} is_a: CHEBI:23132 ! chlorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H2Cl4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "215.892" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "213.89106" xsd:string [Term] id: CHEBI:26895 name: tetracyclines namespace: chebi_ontology def: "A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups." [] subset: 3_STAR is_a: CHEBI:26188 ! polyketide relationship: has_parent_hydride CHEBI:32600 ! tetracene relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:26912 name: oxolanes namespace: chebi_ontology def: "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:26959 name: thiocarboxylic ester namespace: chebi_ontology def: "An ester in which one or both oxygens of an ester group have been replaced by divalent sulfur." [] subset: 3_STAR synonym: "thiocarboxylic esters" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:35701 ! ester [Term] id: CHEBI:26979 name: organic heterotricyclic compound namespace: chebi_ontology def: "An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms." [] subset: 3_STAR synonym: "heterotricyclic compounds" RELATED [ChEBI] synonym: "organic heterotricyclic compounds" RELATED [ChEBI] is_a: CHEBI:36688 ! heterotricyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound is_a: CHEBI:51959 ! organic tricyclic compound [Term] id: CHEBI:27026 name: toxin namespace: chebi_ontology def: "Poisonous substance produced by a biological organism such as a microbe, animal or plant." [] subset: 3_STAR synonym: "toxin" EXACT IUPAC_NAME [IUPAC] synonym: "toxins" RELATED [ChEBI] xref: Wikipedia:Toxin is_a: CHEBI:25212 ! metabolite is_a: CHEBI:64909 ! poison [Term] id: CHEBI:27027 name: micronutrient namespace: chebi_ontology def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." [] subset: 3_STAR synonym: "micronutrients" RELATED [ChEBI] synonym: "trace elements" RELATED [ChEBI] xref: Wikipedia:Micronutrient is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:27081 name: transition element atom namespace: chebi_ontology def: "An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell." [] subset: 3_STAR synonym: "metal de transicion" RELATED [ChEBI] synonym: "metal de transition" RELATED [ChEBI] synonym: "metales de transicion" RELATED [ChEBI] synonym: "metaux de transition" RELATED [ChEBI] synonym: "transition element" EXACT IUPAC_NAME [IUPAC] synonym: "transition element" RELATED [ChEBI] synonym: "transition elements" RELATED [ChEBI] synonym: "transition metal" RELATED [ChEBI] synonym: "transition metals" RELATED [ChEBI] synonym: "Uebergangselement" RELATED [ChEBI] synonym: "Uebergangsmetalle" RELATED [ChEBI] is_a: CHEBI:33521 ! metal atom [Term] id: CHEBI:27096 name: trichlorobenzene namespace: chebi_ontology def: "Any member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions." [] subset: 3_STAR synonym: "Trichlorbenzol" RELATED [ChEBI] synonym: "trichlorobenzene" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Trichlorobenzene is_a: CHEBI:23132 ! chlorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H3Cl3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "181.447" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "179.93003" xsd:string [Term] id: CHEBI:27136 name: triol namespace: chebi_ontology def: "A chemical compound containing three hydroxy groups." [] subset: 3_STAR synonym: "triols" RELATED [ChEBI] is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:27171 name: organic heterobicyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterobicyclic compounds" RELATED [ChEBI] synonym: "organic heterobicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33672 ! heterobicyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:27207 name: univalent carboacyl group namespace: chebi_ontology def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "univalent acyl group" RELATED [ChEBI] synonym: "univalent carboacyl groups" RELATED [ChEBI] synonym: "univalent carboxylic acyl groups" RELATED [ChEBI] is_a: CHEBI:37838 ! carboacyl group [Term] id: CHEBI:27208 name: unsaturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing at least one C=C or C#C bond." [] subset: 3_STAR synonym: "alkene acid" RELATED [ChEBI] synonym: "olefinic acid" RELATED [ChEBI] synonym: "unsaturated fatty acids" RELATED [LIPID_MAPS] synonym: "unsaturated fatty acids" RELATED [ChEBI] xref: LIPID_MAPS_class:LMFA0103 {source="LIPID MAPS"} xref: PMID:5322381 {source="Europe PMC"} is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:2580 ! unsaturated fatty acid anion [Term] id: CHEBI:27242 name: uridines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:39446 ! pyrimidine ribonucleosides relationship: has_functional_parent CHEBI:17568 ! uracil [Term] id: CHEBI:27283 name: very long-chain fatty acid namespace: chebi_ontology def: "A fatty acid which has a chain length greater than C22. Very long-chain fatty acids which have a chain length greater than C27 are also known as ultra-long-chain fatty acids." [] subset: 3_STAR synonym: "higher fatty acid" RELATED [ChEBI] synonym: "very long-chain fatty acids" RELATED [ChEBI] synonym: "VLCFA" RELATED [ChEBI] synonym: "VLCFAs" RELATED [ChEBI] xref: LIPID_MAPS_instance:LMFA01010025 {source="LIPID MAPS"} is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:58950 ! very long-chain fatty acid anion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2OR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "45.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string [Term] id: CHEBI:27311 name: volatile oil component namespace: chebi_ontology def: "Any plant metabolite that is found naturally as a component of a volatile oil." [] subset: 3_STAR synonym: "essential oil component" RELATED [ChEBI] synonym: "essential oil components" RELATED [ChEBI] synonym: "ethereal oil component" RELATED [ChEBI] synonym: "ethereal oil components" RELATED [ChEBI] synonym: "volatile oil components" RELATED [ChEBI] xref: Wikipedia:Essential_oil is_a: CHEBI:76924 ! plant metabolite [Term] id: CHEBI:27314 name: water-soluble vitamin (role) namespace: chebi_ontology def: "Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine." [] subset: 3_STAR synonym: "wasserloesliche Vitamine" RELATED [ChEBI] synonym: "water-soluble vitamin" RELATED [ChEBI] synonym: "water-soluble vitamins" RELATED [ChEBI] is_a: CHEBI:33229 ! vitamin (role) [Term] id: CHEBI:27363 name: zinc atom namespace: chebi_ontology subset: 3_STAR synonym: "30Zn" RELATED [IUPAC] synonym: "cinc" RELATED [ChEBI] synonym: "zinc" EXACT IUPAC_NAME [IUPAC] synonym: "zinc" RELATED [ChEBI] synonym: "zincum" RELATED [ChEBI] synonym: "Zink" RELATED [ChEBI] synonym: "Zn" RELATED [IUPAC] synonym: "Zn(II)" RELATED [KEGG_COMPOUND] synonym: "Zn2+" RELATED [KEGG_COMPOUND] xref: CAS:7440-66-6 {source="ChemIDplus"} xref: CAS:7440-66-6 {source="KEGG COMPOUND"} xref: Gmelin:16321 {source="Gmelin"} xref: KEGG:C00038 xref: PDBeChem:ZN xref: WebElements:Zn is_a: CHEBI:33340 ! zinc group element atom relationship: RO:0000087 CHEBI:27027 ! has role micronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Zn" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Zn" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HCHKCACWOHOZIP-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "65.39000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "63.92914" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Zn]" xsd:string [Term] id: CHEBI:27364 name: zinc molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc compounds" RELATED [ChEBI] synonym: "zinc molecular entities" RELATED [ChEBI] is_a: CHEBI:33673 ! zinc group molecular entity relationship: has_part CHEBI:27363 ! zinc atom [Term] id: CHEBI:27369 name: zwitterion namespace: chebi_ontology def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." [] subset: 3_STAR synonym: "compose zwitterionique" RELATED [IUPAC] synonym: "compuestos zwitterionicos" RELATED [IUPAC] synonym: "zwitterion" EXACT IUPAC_NAME [IUPAC] synonym: "zwitteriones" RELATED [IUPAC] synonym: "zwitterionic compounds" RELATED [IUPAC] synonym: "zwitterions" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51151 ! dipolar compound [Term] id: CHEBI:27405 name: streptidine namespace: chebi_ontology alt_id: CHEBI:26781 alt_id: CHEBI:9280 def: "An amino cyclitol that is scyllo-inositol in which the hydroxy groups at positions 1 and 3 are replaced by guanidino groups." [] subset: 3_STAR synonym: "1,1'-(2,4,5,6-Tetrahydroxy-1,3-cyclohexylene)diguanidine" RELATED [ChemIDplus] synonym: "1,1'-[(1R,2s,3S,4R,5r,6S)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine" EXACT IUPAC_NAME [IUPAC] synonym: "1,3-diguanidino-2,4,5,6-cyclohexanetetrol" RELATED [ChEBI] synonym: "N,N'''-[(1R,2s,3S,4R,5r,6S)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine" EXACT IUPAC_NAME [IUPAC] synonym: "N,N'-bis(aminoiminomethyl)streptamine" RELATED [ChEBI] synonym: "N,N'-diamidinostreptamine" RELATED [ChEBI] synonym: "Streptamine, N,N'-bis(aminoiminomethyl)-" RELATED [ChemIDplus] synonym: "streptidin" RELATED [ChemIDplus] synonym: "Streptidine" EXACT [KEGG_COMPOUND] xref: CAS:85-17-6 {source="ChemIDplus"} xref: CAS:85-17-6 {source="KEGG COMPOUND"} xref: HMDB:HMDB0258506 xref: KEGG:C00837 xref: MetaCyc:CPD-10148 xref: PMID:11642734 {source="Europe PMC"} xref: PMID:15736038 {source="Europe PMC"} xref: PMID:16956741 {source="Europe PMC"} xref: PMID:17011831 {source="Europe PMC"} xref: PMID:17609790 {source="Europe PMC"} xref: PMID:6076630 {source="Europe PMC"} xref: Reaxys:2816623 {source="Reaxys"} is_a: CHEBI:24436 ! guanidines is_a: CHEBI:61689 ! amino cyclitol relationship: has_functional_parent CHEBI:10642 ! scyllo-inositol relationship: is_conjugate_base_of CHEBI:184376 ! streptidine(2+) relationship: RO:0000087 CHEBI:25212 ! has role metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H18N6O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H18N6O4/c9-7(10)13-1-3(15)2(14-8(11)12)5(17)6(18)4(1)16/h1-6,15-18H,(H4,9,10,13)(H4,11,12,14)/t1-,2+,3-,4+,5-,6-" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MSXMXWJPFIDEMT-FAEUDGQSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "262.26630" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "262.13895" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=N)N[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@@H]1O" xsd:string [Term] id: CHEBI:27412 name: gentamycin C1 namespace: chebi_ontology alt_id: CHEBI:24209 alt_id: CHEBI:5309 subset: 3_STAR synonym: "(1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-beta-L-lyxo-heptopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "Gentamicin C1" RELATED [KEGG_COMPOUND] synonym: "O-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-ribo-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-D-streptamine" RELATED [ChemIDplus] xref: CAS:25876-10-2 {source="ChemIDplus"} xref: CAS:25876-10-2 {source="KEGG COMPOUND"} xref: KEGG:C07656 is_a: CHEBI:28417 ! gentamycin C property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H43N5O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3/t9?,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CEAZRRDELHUEMR-URQXQFDESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "477.59562" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "477.31625" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CNC(C)[C@@H]1CC[C@@H](N)[C@H](O1)O[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O[C@H]2OC[C@](C)(O)[C@H](NC)[C@H]2O)[C@H]1O" xsd:string [Term] id: CHEBI:27561 name: oxirane namespace: chebi_ontology alt_id: CHEBI:24001 alt_id: CHEBI:4900 def: "A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom." [] subset: 3_STAR synonym: "1,2-Epoxyaethan" RELATED [ChemIDplus] synonym: "1,2-epoxyethane" RELATED [NIST_Chemistry_WebBook] synonym: "Aethylenoxid" RELATED [ChemIDplus] synonym: "Amprolene" RELATED [ChemIDplus] synonym: "Anprolene" RELATED [NIST_Chemistry_WebBook] synonym: "Anproline" RELATED [ChemIDplus] synonym: "Dihydrooxirene" RELATED [ChemIDplus] synonym: "Dimethylene oxide" RELATED [ChemIDplus] synonym: "epoxyethane" RELATED [NIST_Chemistry_WebBook] synonym: "ethene oxide" RELATED [NIST_Chemistry_WebBook] synonym: "Ethylene oxide" RELATED [KEGG_COMPOUND] synonym: "ETO" RELATED [ChemIDplus] synonym: "Oxacyclopropane" RELATED [ChemIDplus] synonym: "Oxane" RELATED [ChemIDplus] synonym: "Oxidoethane" RELATED [ChemIDplus] synonym: "oxirane" EXACT IUPAC_NAME [IUPAC] synonym: "oxyde d'ethylene" RELATED [ChemIDplus] synonym: "Oxyfume" RELATED [ChEBI] xref: Beilstein:102378 {source="Beilstein"} xref: CAS:75-21-8 {source="NIST Chemistry WebBook"} xref: CAS:75-21-8 {source="KEGG COMPOUND"} xref: CAS:75-21-8 {source="ChemIDplus"} xref: Gmelin:676 {source="Gmelin"} xref: HMDB:HMDB0031305 xref: KEGG:C06548 xref: KEGG:D03474 xref: PMID:11437638 {source="Europe PMC"} xref: PMID:24313866 {source="Europe PMC"} xref: PMID:24882394 {source="Europe PMC"} xref: PMID:25005741 {source="Europe PMC"} xref: PMID:3932500 {source="Europe PMC"} xref: Reaxys:102378 {source="Reaxys"} xref: UM-BBD_compID:c0527 {source="UM-BBD"} xref: Wikipedia:Oxirane is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:36389 ! saturated organic heteromonocyclic parent is_a: CHEBI:38104 ! oxacycle relationship: RO:0000087 CHEBI:25435 ! has role mutagen relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4O/c1-2-3-1/h1-2H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IAYPIBMASNFSPL-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.05256" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.02621" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1CO1" xsd:string [Term] id: CHEBI:27565 name: 4-aminosalicylic acid namespace: chebi_ontology alt_id: CHEBI:1789 alt_id: CHEBI:20320 alt_id: CHEBI:41152 def: "An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4." [] subset: 3_STAR synonym: "2-HYDROXY-4-AMINOBENZOIC ACID" RELATED [PDBeChem] synonym: "4-amino-2-hydroxybenzoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "4-Aminosalicylate" RELATED [KEGG_COMPOUND] synonym: "4-Aminosalicylic acid" EXACT [KEGG_COMPOUND] synonym: "Aminosalicylic acid" RELATED [ChemIDplus] synonym: "p-aminosalicylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Para-amino salicylic acid" RELATED [ChemIDplus] synonym: "PAS" RELATED [ChemIDplus] synonym: "Paser" RELATED BRAND_NAME [DrugBank] xref: Beilstein:473071 {source="Beilstein"} xref: CAS:65-49-6 {source="NIST Chemistry WebBook"} xref: CAS:65-49-6 {source="ChemIDplus"} xref: CAS:65-49-6 {source="KEGG COMPOUND"} xref: Drug_Central:2050 {source="DrugCentral"} xref: DrugBank:DB00233 xref: Gmelin:306153 {source="Gmelin"} xref: HMDB:HMDB0014378 xref: KEGG:C02518 xref: KEGG:D00162 xref: LINCS:LSM-5862 xref: Patent:DE50835 xref: Patent:US2844625 xref: Patent:US427564 xref: PDBeChem:BHA xref: PMID:11621575 {source="Europe PMC"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:23118010 {source="Europe PMC"} xref: PMID:24663015 {source="Europe PMC"} xref: PMID:25050392 {source="Europe PMC"} xref: PMID:25421465 {source="Europe PMC"} xref: PMID:25605031 {source="Europe PMC"} xref: PMID:25963985 {source="Europe PMC"} xref: PMID:26004847 {source="Europe PMC"} xref: PMID:26033719 {source="Europe PMC"} xref: PMID:26277036 {source="Europe PMC"} xref: PMID:26596566 {source="Europe PMC"} xref: PMID:26848874 {source="Europe PMC"} xref: PMID:27021327 {source="Europe PMC"} xref: PMID:27491492 {source="Europe PMC"} xref: PMID:27617928 {source="Europe PMC"} xref: PMID:27671064 {source="Europe PMC"} xref: PMID:28011126 {source="Europe PMC"} xref: PMID:28223391 {source="Europe PMC"} xref: PMID:28394286 {source="Europe PMC"} xref: PMID:28408267 {source="Europe PMC"} xref: PMID:28567674 {source="Europe PMC"} xref: PMID:28651968 {source="Europe PMC"} xref: PMID:28717039 {source="Europe PMC"} xref: PMID:28812999 {source="Europe PMC"} xref: Reaxys:473071 {source="Reaxys"} xref: Wikipedia:Aminosalicylic_Acid is_a: CHEBI:22495 ! aminobenzoic acid is_a: CHEBI:33853 ! phenols relationship: has_functional_parent CHEBI:16914 ! salicylic acid relationship: is_conjugate_acid_of CHEBI:137598 ! 4-aminosalicylate(1-) relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H7NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WUBBRNOQWQTFEX-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "153.13540" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "153.04259" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ccc(C(O)=O)c(O)c1" xsd:string [Term] id: CHEBI:27594 name: carbon atom namespace: chebi_ontology alt_id: CHEBI:23009 alt_id: CHEBI:3399 subset: 3_STAR synonym: "6C" RELATED [IUPAC] synonym: "C" RELATED [KEGG_COMPOUND] synonym: "C" RELATED [IUPAC] synonym: "Carbon" RELATED [KEGG_COMPOUND] synonym: "carbon" EXACT IUPAC_NAME [IUPAC] synonym: "carbon" RELATED [ChEBI] synonym: "carbone" RELATED [ChEBI] synonym: "carbonium" RELATED [ChEBI] synonym: "carbono" RELATED [ChEBI] synonym: "Kohlenstoff" RELATED [ChEBI] xref: CAS:7440-44-0 {source="ChemIDplus"} xref: CAS:7440-44-0 {source="KEGG COMPOUND"} xref: KEGG:C06265 xref: WebElements:C is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33306 ! carbon group element atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OKTJSMMVPCPJKN-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "12.01070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "12.00000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C]" xsd:string [Term] id: CHEBI:2762 name: antimycin A namespace: chebi_ontology alt_id: CHEBI:22584 alt_id: CHEBI:40908 def: "A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison." [] subset: 3_STAR synonym: "(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate" EXACT IUPAC_NAME [IUPAC] synonym: "Antimycin A1" RELATED [KEGG_COMPOUND] synonym: "antimycin A1b" RELATED [ChEBI] synonym: "Antipiricullin" RELATED [ChemIDplus] synonym: "Fintrol" RELATED [ChemIDplus] synonym: "Virosin" RELATED [ChemIDplus] xref: Beilstein:72665 {source="Beilstein"} xref: CAS:1397-94-0 {source="ChemIDplus"} xref: CAS:642-15-9 {source="ChemIDplus"} xref: CAS:642-15-9 {source="KEGG COMPOUND"} xref: KEGG:C11339 xref: MetaCyc:CPD-5744 xref: PDBeChem:AY1 xref: PMID:16819166 {source="Europe PMC"} xref: PMID:29790043 {source="Europe PMC"} xref: PMID:30914247 {source="Europe PMC"} xref: PMID:31079230 {source="Europe PMC"} xref: PMID:32662599 {source="Europe PMC"} is_a: CHEBI:145556 ! macrodiolide is_a: CHEBI:22702 ! benzamides is_a: CHEBI:24079 ! formamides is_a: CHEBI:33853 ! phenols relationship: RO:0000087 CHEBI:167183 ! has role piscicide relationship: RO:0000087 CHEBI:25355 ! has role mitochondrial respiratory-chain inhibitor relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C28H40N2O9" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20-,23+,25+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UIFFUZWRFRDZJC-SBOOETFBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "548.633" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "548.27338" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1([C@H]([C@H](OC([C@@H]([C@H]([C@@H](O1)C)OC(CC(C)C)=O)CCCCCC)=O)C)NC(C2=C(C(=CC=C2)NC(=O)[H])O)=O)=O" xsd:string [Term] id: CHEBI:27641 name: cycloheximide namespace: chebi_ontology alt_id: CHEBI:23484 alt_id: CHEBI:4015 def: "A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus." [] subset: 3_STAR synonym: "3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide" RELATED [ChemIDplus] synonym: "4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione" EXACT IUPAC_NAME [IUPAC] synonym: "cicloheximida" RELATED INN [ChemIDplus] synonym: "cicloheximide" RELATED INN [WHO_MedNet] synonym: "cicloheximidum" RELATED INN [ChemIDplus] synonym: "Cycloheximid" RELATED [ChEBI] synonym: "Cycloheximide" EXACT [KEGG_COMPOUND] synonym: "cycloheximide" EXACT [UniProt] synonym: "naramycin" RELATED [ChemIDplus] synonym: "naramycin A" RELATED [ChemIDplus] synonym: "Zykloheximid" RELATED [ChEBI] xref: Beilstein:88868 {source="Beilstein"} xref: CAS:66-81-9 {source="ChemIDplus"} xref: CAS:66-81-9 {source="KEGG COMPOUND"} xref: KEGG:C06685 xref: KEGG:D03625 xref: KNApSAcK:C00047211 xref: LINCS:LSM-2791 xref: PDBeChem:3HE xref: PMID:11972861 {source="Europe PMC"} xref: PMID:16659174 {source="Europe PMC"} xref: PMID:25209664 {source="Europe PMC"} xref: PMID:26715760 {source="Europe PMC"} xref: PMID:27192630 {source="Europe PMC"} xref: PMID:27665925 {source="Europe PMC"} xref: PMID:30154175 {source="Europe PMC"} xref: PMID:30916348 {source="Europe PMC"} xref: PMID:32299921 {source="Europe PMC"} xref: PMID:33101237 {source="Europe PMC"} xref: PPDB:1680 xref: Reaxys:88868 {source="Reaxys"} xref: Wikipedia:Cycloheximide is_a: CHEBI:35356 ! dicarboximide is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:48589 ! piperidones is_a: CHEBI:49318 ! piperidine antibiotic is_a: CHEBI:87114 ! antibiotic fungicide relationship: has_functional_parent CHEBI:5435 ! piperidine-2,6-dione relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:173084 ! has role ferroptosis inhibitor relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H23NO4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YPHMISFOHDHNIV-FSZOTQKASA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "281.352" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "281.16271" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1" xsd:string [Term] id: CHEBI:27644 name: chlortetracycline namespace: chebi_ontology alt_id: CHEBI:23164 alt_id: CHEBI:3653 def: "A member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens." [] subset: 3_STAR synonym: "(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "7-Chlorotetracycline" RELATED [KEGG_COMPOUND] synonym: "Aueromycin" RELATED BRAND_NAME [KEGG_DRUG] synonym: "chlortetracycline" RELATED INN [WHO_MedNet] synonym: "chlortetracyclinum" RELATED INN [WHO_MedNet] synonym: "clortetraciclina" RELATED INN [WHO_MedNet] xref: CAS:57-62-5 {source="ChemIDplus"} xref: CAS:57-62-5 {source="KEGG COMPOUND"} xref: Drug_Central:624 {source="DrugCentral"} xref: HMDB:HMDB0014401 xref: KEGG:C06571 xref: KEGG:D07689 xref: LIPID_MAPS_instance:LMPK07000004 {source="LIPID MAPS"} xref: Patent:US2482055 xref: PDBeChem:CTC xref: PMID:23530364 {source="Europe PMC"} xref: PMID:24845506 {source="Europe PMC"} xref: PMID:25131164 {source="Europe PMC"} xref: PMID:25602656 {source="Europe PMC"} xref: PMID:7150561 {source="Europe PMC"} xref: PMID:7390959 {source="Europe PMC"} xref: PMID:7988792 {source="Europe PMC"} is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:83403 ! monochlorobenzenes relationship: is_conjugate_acid_of CHEBI:133598 ! chlortetracycline(1-) relationship: RO:0000087 CHEBI:22986 ! has role calcium ionophore relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:39442 ! has role fluorescent probe property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H23ClN2O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CYDMQBQPVICBEU-XRNKAMNCSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "478.88000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "478.11429" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)ccc(Cl)c1[C@@]3(C)O" xsd:string [Term] id: CHEBI:27656 name: camptothecin namespace: chebi_ontology alt_id: CHEBI:22997 alt_id: CHEBI:3343 def: "A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer)." [] subset: 3_STAR synonym: "(+)-camptothecin" RELATED [DrugBank] synonym: "(+)-camptothecine" RELATED [DrugBank] synonym: "(4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione" EXACT IUPAC_NAME [IUPAC] synonym: "(S)-(+)-camptothecin" RELATED [DrugBank] synonym: "20(S)-camptothecine" RELATED [ChemIDplus] synonym: "21,22-Secocamptothecin-21-oic acid lactone" RELATED [ChemIDplus] synonym: "Camptothecin" EXACT [KEGG_COMPOUND] synonym: "Camptothecine" RELATED [ChemIDplus] synonym: "CPT" RELATED [DrugBank] synonym: "D-camptothecin" RELATED [DrugBank] xref: Beilstein:6075662 {source="Beilstein"} xref: CAS:7689-03-4 {source="ChemIDplus"} xref: DrugBank:DB04690 xref: KEGG:C01897 xref: KNApSAcK:C00002145 xref: LINCS:LSM-4611 xref: PDBeChem:EHD xref: PMID:11024478 {source="Europe PMC"} xref: PMID:11549373 {source="Europe PMC"} xref: PMID:23344961 {source="Europe PMC"} xref: PMID:23474217 {source="Europe PMC"} xref: PMID:23676007 {source="Europe PMC"} xref: PMID:8965250 {source="Europe PMC"} xref: Reaxys:6075662 {source="Reaxys"} xref: Wikipedia:Camptothecin is_a: CHEBI:18946 ! delta-lactone is_a: CHEBI:26509 ! quinoline alkaloid is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:48626 ! pyranoindolizinoquinoline relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:50276 ! has role EC 5.99.1.2 (DNA topoisomerase) inhibitor relationship: RO:0000087 CHEBI:50902 ! has role genotoxin relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H16N2O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VSJKWCGYPAHWDS-FQEVSTJZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "348.35200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "348.11101" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O" xsd:string [Term] id: CHEBI:27666 name: actinomycin D namespace: chebi_ontology alt_id: CHEBI:22218 alt_id: CHEBI:2446 subset: 3_STAR synonym: "2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis-[(18aS)-10c,14,17-trimethyl-5,8,12,15,18-pentaoxo-6c,13t-di(propan-2-yl)-18ar-hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-9c-yl]-3H-phenoxazine-1,9-dicarboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide" RELATED [ChemIDplus] synonym: "ActD" RELATED [ChEBI] synonym: "actinomycin C1" RELATED [ChEBI] synonym: "Actinomycin D" EXACT [KEGG_COMPOUND] synonym: "actinomycin IV" RELATED [ChemIDplus] synonym: "Dactinomycin" RELATED [KEGG_COMPOUND] xref: Beilstein:4173766 {source="Beilstein"} xref: CAS:50-76-0 {source="ChemIDplus"} xref: CAS:50-76-0 {source="KEGG COMPOUND"} xref: Drug_Central:774 {source="DrugCentral"} xref: DrugBank:DB00970 xref: KEGG:C06770 xref: KEGG:D00214 xref: LINCS:LSM-5783 xref: Wikipedia:Dactinomycin is_a: CHEBI:15369 ! actinomycin relationship: RO:0000087 CHEBI:25435 ! has role mutagen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C62H86N12O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RJURFGZVJUQBHK-IIXSONLDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1255.41700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1254.62847" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C" xsd:string [Term] id: CHEBI:27701 name: oxytetracycline namespace: chebi_ontology alt_id: CHEBI:25811 alt_id: CHEBI:521157 alt_id: CHEBI:596903 alt_id: CHEBI:7871 def: "A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae." [] subset: 3_STAR synonym: "(4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "5-Hydroxytetracycline" RELATED [ChemIDplus] synonym: "oxitetraciclina" RELATED INN [ChemIDplus] synonym: "Oxyterracin" RELATED [ChemIDplus] synonym: "Oxyterracine" RELATED [ChemIDplus] synonym: "Oxytetracyclin" RELATED [ChemIDplus] synonym: "Oxytetracycline (anhydrous)" RELATED [ChemIDplus] synonym: "Oxytetracycline amphoteric" RELATED [ChemIDplus] synonym: "oxytetracyclinum" RELATED INN [ChemIDplus] xref: Beilstein:2686362 {source="Beilstein"} xref: Beilstein:2714587 {source="Beilstein"} xref: BPDB:503 xref: CAS:79-57-2 {source="ChemIDplus"} xref: CAS:79-57-2 {source="KEGG COMPOUND"} xref: Drug_Central:2041 {source="DrugCentral"} xref: DrugBank:DB00595 xref: Gmelin:623487 {source="Gmelin"} xref: HMDB:HMDB0014733 xref: KEGG:C06624 xref: KNApSAcK:C00017127 xref: LIPID_MAPS_instance:LMPK07000005 {source="LIPID MAPS"} xref: Pesticides:oxytetracycline {source="Alan Wood's Pesticides"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:17386724 {source="Europe PMC"} xref: PMID:17638695 {source="ChEMBL"} xref: PMID:17870541 {source="ChEMBL"} xref: PMID:1833366 {source="Europe PMC"} xref: PMID:21136283 {source="Europe PMC"} xref: PMID:21488905 {source="Europe PMC"} xref: PMID:22013404 {source="Europe PMC"} xref: PMID:24247133 {source="Europe PMC"} xref: PMID:24281679 {source="Europe PMC"} xref: PMID:24290103 {source="Europe PMC"} xref: PMID:24362004 {source="Europe PMC"} xref: PMID:24510709 {source="Europe PMC"} xref: PMID:24607684 {source="Europe PMC"} xref: PMID:24853528 {source="Europe PMC"} xref: PMID:24983832 {source="Europe PMC"} xref: PMID:25019386 {source="Europe PMC"} xref: PMID:25035320 {source="Europe PMC"} xref: PMID:25081007 {source="Europe PMC"} xref: Reaxys:2714587 {source="Reaxys"} xref: VSDB:503 xref: Wikipedia:Oxytetracycline is_a: CHEBI:26895 ! tetracyclines relationship: is_tautomer_of CHEBI:133011 ! oxytetracycline zwitterion relationship: RO:0000087 CHEBI:35472 ! has role anti-inflammatory drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H24N2O9" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IWVCMVBTMGNXQD-PXOLEDIWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "460.43400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "460.14818" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C" xsd:string [Term] id: CHEBI:27780 name: detergent namespace: chebi_ontology alt_id: CHEBI:23648 alt_id: CHEBI:4456 def: "A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions." [] subset: 3_STAR synonym: "detergent" EXACT IUPAC_NAME [IUPAC] synonym: "Detergents" RELATED [KEGG_COMPOUND] xref: KEGG:C01689 is_a: CHEBI:33232 ! application is_a: CHEBI:35195 ! surfactant [Term] id: CHEBI:27822 name: 2-aminobenzimidazole namespace: chebi_ontology alt_id: CHEBI:1016 alt_id: CHEBI:19467 def: "A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group." [] subset: 3_STAR synonym: "1H-benzimidazol-2-amine" EXACT IUPAC_NAME [IUPAC] synonym: "2-Aminobenzimidazole" EXACT [KEGG_COMPOUND] synonym: "2-aminobenzimidazole" EXACT [UniProt] synonym: "2-Iminobenzimidazoline" RELATED [ChemIDplus] synonym: "Benzimidazol-2-ylamine" RELATED [ChemIDplus] xref: Beilstein:116525 {source="Beilstein"} xref: CAS:934-32-7 {source="NIST Chemistry WebBook"} xref: CAS:934-32-7 {source="ChemIDplus"} xref: CAS:934-32-7 {source="KEGG COMPOUND"} xref: KEGG:C10901 xref: PDBeChem:AX7 xref: PMID:22076761 {source="Europe PMC"} xref: PMID:22488868 {source="Europe PMC"} xref: PMID:22958065 {source="Europe PMC"} xref: PMID:24098350 {source="Europe PMC"} xref: Reaxys:116525 {source="Reaxys"} is_a: CHEBI:22715 ! benzimidazoles relationship: RO:0000087 CHEBI:83399 ! has role marine xenobiotic metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H7N3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H7N3/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H3,8,9,10)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JWYUFVNJZUSCSM-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "133.15070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "133.06400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1nc2ccccc2[nH]1" xsd:string [Term] id: CHEBI:27881 name: resveratrol namespace: chebi_ontology alt_id: CHEBI:11685 alt_id: CHEBI:1366 alt_id: CHEBI:19867 def: "A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups." [] subset: 3_STAR synonym: "3,4',5-Trihydroxystilbene" RELATED [KEGG_COMPOUND] synonym: "5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol" EXACT IUPAC_NAME [IUPAC] synonym: "Resveratrol" EXACT [KEGG_COMPOUND] xref: Beilstein:1912433 {source="Beilstein"} xref: CAS:501-36-0 {source="KEGG COMPOUND"} xref: DrugBank:DB02709 xref: KEGG:C03582 xref: LINCS:LSM-2557 xref: PMID:12939617 {source="Europe PMC"} xref: PMID:16461283 {source="Europe PMC"} is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:33572 ! resorcinols is_a: CHEBI:36027 ! stilbenol relationship: RO:0000087 CHEBI:140922 ! has role glioma-associated oncogene inhibitor relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:22586 ! has role antioxidant relationship: RO:0000087 CHEBI:26115 ! has role phytoalexin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H12O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LUKBXSAWLPMMSZ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "228.24328" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "228.07864" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=C([H])c1cc(O)cc(O)c1)c1ccc(O)cc1" xsd:string [Term] id: CHEBI:27902 name: tetracycline namespace: chebi_ontology alt_id: CHEBI:26894 alt_id: CHEBI:45729 alt_id: CHEBI:9474 def: "A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria." [] subset: 3_STAR synonym: "(4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide" RELATED [ChemIDplus] synonym: "(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "Abramycin" RELATED [ChemIDplus] synonym: "Achromycin" RELATED [ChEBI] synonym: "Anhydrotetracycline" RELATED [DrugBank] synonym: "Deschlorobiomycin" RELATED [ChemIDplus] synonym: "Liquamycin" RELATED [ChemIDplus] synonym: "Tetracyclin" RELATED [ChEBI] synonym: "TETRACYCLINE" EXACT [PDBeChem] synonym: "Tetracycline" EXACT [KEGG_COMPOUND] synonym: "tetracycline" EXACT [ChEBI] synonym: "tetracycline" RELATED INN [ChemIDplus] synonym: "tetracyclinum" RELATED INN [ChemIDplus] synonym: "Tetrazyklin" RELATED [ChEBI] synonym: "Tsiklomitsin" RELATED [ChemIDplus] xref: Beilstein:2230417 {source="Beilstein"} xref: CAS:60-54-8 {source="ChemIDplus"} xref: CAS:60-54-8 {source="KEGG COMPOUND"} xref: Drug_Central:2611 {source="DrugCentral"} xref: DrugBank:DB00759 xref: Gmelin:1103368 {source="Gmelin"} xref: KEGG:C06570 xref: KEGG:D00201 xref: MetaCyc:CPD0-1414 xref: Patent:US2699054 xref: Patent:US2712517 xref: Patent:US2886595 xref: Patent:US3005023 xref: Patent:US3019173 xref: Patent:US3301899 xref: PDBeChem:TAC xref: PMID:11061623 {source="Europe PMC"} xref: PMID:11550419 {source="Europe PMC"} xref: PMID:11744940 {source="Europe PMC"} xref: PMID:12934399 {source="Europe PMC"} xref: PMID:14585720 {source="Europe PMC"} xref: PMID:15825421 {source="Europe PMC"} xref: PMID:15913752 {source="Europe PMC"} xref: PMID:16443056 {source="Europe PMC"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:16749547 {source="Europe PMC"} xref: PMID:17251127 {source="Europe PMC"} xref: PMID:17260506 {source="Europe PMC"} xref: PMID:18326855 {source="Europe PMC"} xref: PMID:18406588 {source="Europe PMC"} xref: PMID:19032078 {source="Europe PMC"} xref: PMID:19112759 {source="Europe PMC"} xref: PMID:19136803 {source="Europe PMC"} xref: PMID:25286144 {source="Europe PMC"} xref: PMID:26876942 {source="Europe PMC"} xref: Reaxys:2230417 {source="Reaxys"} xref: VSDB:1739 xref: Wikipedia:Tetracycline is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines relationship: is_conjugate_acid_of CHEBI:71392 ! tetracycline(1-) relationship: is_conjugate_acid_of CHEBI:77932 ! tetracycline zwitterion relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H24N2O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OFVLGDICTFRJMM-WESIUVDSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "444.43460" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "444.15327" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C" xsd:string [Term] id: CHEBI:27933 name: beta-lactam antibiotic namespace: chebi_ontology alt_id: CHEBI:10427 alt_id: CHEBI:22844 def: "An organonitrogen heterocyclic antibiotic that contains a beta-lactam ring." [] subset: 3_STAR synonym: "beta-Lactam antibiotics" RELATED [KEGG_COMPOUND] synonym: "beta-lactam antibiotics" RELATED [ChEBI] xref: KEGG:C03438 xref: PMID:19254642 {source="Europe PMC"} xref: PMID:22594007 {source="Europe PMC"} xref: Wikipedia:Beta-lactam_antibiotic is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:35627 ! beta-lactam [Term] id: CHEBI:27955 name: streptamine namespace: chebi_ontology alt_id: CHEBI:26779 alt_id: CHEBI:9277 def: "An amino cyclitol consisting of scyllo-inositol with the hydroxy groups at positions 1 and 3 replaced by unsubstituted amino groups." [] subset: 3_STAR synonym: "(1R,2r,3S,4R,5s,6S)-4,6-diaminocyclohexane-1,2,3,5-tetrol" EXACT IUPAC_NAME [IUPAC] synonym: "1,3-diamino-1,3-dideoxy-scyllo-inositol" EXACT IUPAC_NAME [IUPAC] synonym: "Streptamine" EXACT [KEGG_COMPOUND] xref: Beilstein:26714 {source="Beilstein"} xref: CAS:488-52-8 {source="ChemIDplus"} xref: CAS:488-52-8 {source="KEGG COMPOUND"} xref: KEGG:C01854 xref: Reaxys:2802452 {source="Reaxys"} is_a: CHEBI:61689 ! amino cyclitol relationship: has_functional_parent CHEBI:10642 ! scyllo-inositol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H14N2O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H14N2O4/c7-1-3(9)2(8)5(11)6(12)4(1)10/h1-6,9-12H,7-8H2/t1-,2+,3-,4+,5-,6-" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ANLMVXSIPASBFL-FAEUDGQSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "178.18640" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "178.09536" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H]1[C@H](O)[C@@H](N)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:28001 name: vancomycin namespace: chebi_ontology alt_id: CHEBI:27276 alt_id: CHEBI:49941 alt_id: CHEBI:9931 def: "A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile." [] subset: 3_STAR synonym: "(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid" RELATED [ChEBI] synonym: "(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):C(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]" RELATED [JCBN] synonym: "(3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Vancocin" RELATED BRAND_NAME [KEGG_DRUG] synonym: "vancomicin" RELATED [ChEBI] synonym: "vancomicina" RELATED INN [ChemIDplus] synonym: "VANCOMYCIN" EXACT [PDBeChem] synonym: "Vancomycin" EXACT [KEGG_COMPOUND] synonym: "vancomycin" RELATED INN [ChemIDplus] synonym: "vancomycine" RELATED INN [ChemIDplus] synonym: "vancomycinum" RELATED INN [ChemIDplus] xref: Beilstein:3132 {source="Beilstein"} xref: CAS:1404-90-6 {source="ChemIDplus"} xref: CAS:1404-90-6 {source="KEGG COMPOUND"} xref: Drug_Central:2807 {source="DrugCentral"} xref: DrugBank:DB00512 xref: KEGG:C06689 xref: KEGG:D00212 xref: KNApSAcK:C00016052 xref: MetaCyc:CPD-12245 xref: Patent:US3067099 xref: PDBeChem:VAN xref: PMID:11028184 {source="Europe PMC"} xref: PMID:11408222 {source="Europe PMC"} xref: PMID:11688538 {source="Europe PMC"} xref: PMID:11864951 {source="Europe PMC"} xref: PMID:11886013 {source="Europe PMC"} xref: PMID:11980329 {source="Europe PMC"} xref: PMID:12019070 {source="Europe PMC"} xref: PMID:12541895 {source="Europe PMC"} xref: PMID:12852813 {source="Europe PMC"} xref: PMID:13370625 {source="Europe PMC"} xref: PMID:13521912 {source="Europe PMC"} xref: PMID:14605050 {source="Europe PMC"} xref: PMID:14702667 {source="Europe PMC"} xref: PMID:15047516 {source="Europe PMC"} xref: PMID:15081082 {source="Europe PMC"} xref: PMID:15465645 {source="Europe PMC"} xref: PMID:15590714 {source="Europe PMC"} xref: PMID:15792257 {source="Europe PMC"} xref: PMID:16183423 {source="Europe PMC"} xref: PMID:16184232 {source="Europe PMC"} xref: PMID:16420976 {source="Europe PMC"} xref: PMID:16596002 {source="Europe PMC"} xref: PMID:16720708 {source="Europe PMC"} xref: PMID:17027219 {source="Europe PMC"} xref: PMID:17184835 {source="Europe PMC"} xref: PMID:17299012 {source="Europe PMC"} xref: PMID:17594206 {source="Europe PMC"} xref: PMID:18030187 {source="Europe PMC"} xref: PMID:18159039 {source="Europe PMC"} xref: PMID:18162343 {source="Europe PMC"} xref: PMID:18260149 {source="Europe PMC"} xref: PMID:18361944 {source="Europe PMC"} xref: PMID:18462092 {source="Europe PMC"} xref: PMID:18582342 {source="Europe PMC"} xref: PMID:18817166 {source="Europe PMC"} xref: PMID:18983037 {source="Europe PMC"} xref: PMID:19107100 {source="Europe PMC"} xref: PMID:19830166 {source="Europe PMC"} xref: PMID:20956604 {source="Europe PMC"} xref: PMID:21109901 {source="Europe PMC"} xref: PMID:21458937 {source="Europe PMC"} xref: PMID:21466775 {source="Europe PMC"} xref: PMID:21664803 {source="Europe PMC"} xref: PMID:21719238 {source="Europe PMC"} xref: PMID:21951032 {source="Europe PMC"} xref: PMID:22011388 {source="Europe PMC"} xref: PMID:22015328 {source="Europe PMC"} xref: PMID:22027450 {source="Europe PMC"} xref: PMID:22124537 {source="Europe PMC"} xref: Reaxys:3132 {source="Reaxys"} xref: Wikipedia:Vancomycin is_a: CHEBI:24396 ! glycopeptide relationship: has_functional_parent CHEBI:47724 ! vancomycin aglycone relationship: is_conjugate_base_of CHEBI:76842 ! vancomycin(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C66H75Cl2N9O24" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYPYJXKWCTUITO-LYRMYLQWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1449.25336" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1447.43020" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C(O)=O)c3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1)c(Cl)c2" xsd:string [Term] id: CHEBI:28077 name: rifampicin namespace: chebi_ontology alt_id: CHEBI:26577 alt_id: CHEBI:45308 alt_id: CHEBI:8858 def: "A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)." [] subset: 3_STAR synonym: "(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate" EXACT IUPAC_NAME [IUPAC] synonym: "3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV" RELATED [ChemIDplus] synonym: "RFP" RELATED [DrugBank] synonym: "rifamcin" RELATED [ChEBI] synonym: "Rifampicin" EXACT [KEGG_COMPOUND] synonym: "rifampicin" RELATED INN [KEGG_DRUG] synonym: "rifampicina" RELATED INN [DrugBank] synonym: "rifampicinum" RELATED INN [DrugBank] synonym: "Rifampin" RELATED [KEGG_COMPOUND] xref: Beilstein:5723476 {source="Beilstein"} xref: CAS:13292-46-1 {source="ChemIDplus"} xref: CAS:13292-46-1 {source="KEGG COMPOUND"} xref: DrugBank:DB01045 xref: HMDB:HMDB0015179 xref: KEGG:C06688 xref: KEGG:D00211 xref: Patent:NL6509961 xref: Patent:US3342810 xref: PDBeChem:RFP xref: PMID:11600355 {source="Europe PMC"} xref: PMID:14665784 {source="Europe PMC"} xref: PMID:14670633 {source="Europe PMC"} xref: PMID:15331348 {source="Europe PMC"} xref: PMID:15383168 {source="Europe PMC"} xref: PMID:15705662 {source="Europe PMC"} xref: PMID:16159084 {source="Europe PMC"} xref: PMID:16515773 {source="Europe PMC"} xref: PMID:17828712 {source="Europe PMC"} xref: PMID:18332862 {source="Europe PMC"} xref: PMID:19386087 {source="Europe PMC"} xref: PMID:19458074 {source="Europe PMC"} xref: PMID:19723399 {source="Europe PMC"} xref: PMID:24718527 {source="Europe PMC"} xref: PMID:25720500 {source="Europe PMC"} xref: PMID:26725427 {source="Europe PMC"} xref: PMID:26819743 {source="Europe PMC"} xref: PMID:27082586 {source="Europe PMC"} xref: PMID:27143080 {source="Europe PMC"} xref: PMID:27182275 {source="Europe PMC"} xref: PMID:27242224 {source="Europe PMC"} xref: PMID:27470132 {source="Europe PMC"} xref: PMID:27569735 {source="Europe PMC"} xref: PMID:27617596 {source="Europe PMC"} xref: PMID:27640793 {source="Europe PMC"} xref: PMID:27755552 {source="Europe PMC"} xref: PMID:27795624 {source="Europe PMC"} xref: PMID:27883163 {source="Europe PMC"} xref: PMID:27965540 {source="Europe PMC"} xref: PMID:27993874 {source="Europe PMC"} xref: PMID:28081169 {source="Europe PMC"} xref: PMID:28118809 {source="Europe PMC"} xref: PMID:28181840 {source="Europe PMC"} xref: PMID:28184157 {source="Europe PMC"} xref: PMID:28207542 {source="Europe PMC"} xref: PMID:28262820 {source="Europe PMC"} xref: Reaxys:5723476 {source="Reaxys"} xref: Wikipedia:Rifampicin is_a: CHEBI:26580 ! rifamycins is_a: CHEBI:38532 ! hydrazone is_a: CHEBI:46847 ! N-iminopiperazine is_a: CHEBI:46920 ! N-methylpiperazine is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:72588 ! semisynthetic derivative relationship: is_tautomer_of CHEBI:71365 ! rifampicin zwitterion relationship: RO:0000087 CHEBI:171664 ! has role antiamoebic agent relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug relationship: RO:0000087 CHEBI:37416 ! has role EC 2.7.7.6 (RNA polymerase) inhibitor relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:48422 ! has role angiogenesis inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77318 ! has role pregnane X receptor agonist property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C43H58N4O12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JQXXHWHPUNPDRT-WLSIYKJHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "822.94020" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "822.40512" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\\C=N\\N1CCN(C)CC1)c(O)c4c3C2=O" xsd:string [Term] id: CHEBI:28079 name: beta-L-arabinoside namespace: chebi_ontology alt_id: CHEBI:10422 alt_id: CHEBI:22818 subset: 3_STAR synonym: "beta-L-Arabinoside" EXACT [KEGG_COMPOUND] synonym: "beta-L-arabinosides" RELATED [ChEBI] xref: KEGG:C02761 is_a: CHEBI:22601 ! arabinoside [Term] id: CHEBI:28084 name: 3-(carbamoyloxymethyl)cephalosporin namespace: chebi_ontology alt_id: CHEBI:1462 alt_id: CHEBI:19970 subset: 3_STAR synonym: "3-(carbamoyloxymethyl)cephalosporins" RELATED [ChEBI] synonym: "3-Carbamoyloxymethylcephem" RELATED [KEGG_COMPOUND] xref: KEGG:C03674 is_a: CHEBI:23066 ! cephalosporin [Term] id: CHEBI:28098 name: kanamycin B namespace: chebi_ontology alt_id: CHEBI:14489 alt_id: CHEBI:24948 alt_id: CHEBI:24949 alt_id: CHEBI:6107 subset: 3_STAR synonym: "(1R,2S,3S,4R,6S)-4,6-diamino-3-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "2'-amino-2'-deoxykanamycin" RELATED [ChemIDplus] synonym: "Bekanamycin" RELATED [KEGG_COMPOUND] synonym: "Kanamycin B" EXACT [KEGG_COMPOUND] synonym: "Nebramycin factor 5" RELATED [KEGG_COMPOUND] synonym: "Nebramycin V" RELATED [ChemIDplus] synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->6))-2-deoxy-D-streptamine" RELATED [ChemIDplus] xref: Beilstein:61646 {source="Beilstein"} xref: CAS:4696-76-8 {source="KEGG COMPOUND"} xref: CAS:4696-76-8 {source="ChemIDplus"} xref: Drug_Central:1520 {source="DrugCentral"} xref: KEGG:C00825 xref: KEGG:D07497 xref: KNApSAcK:C00018692 xref: PDBeChem:9CS is_a: CHEBI:24951 ! kanamycins relationship: is_conjugate_base_of CHEBI:58549 ! kanamycin B(5+) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H37N5O10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SKKLOUVUUNMCJE-FQSMHNGLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "483.51390" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "483.25404" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:28201 name: rotenone namespace: chebi_ontology alt_id: CHEBI:26583 alt_id: CHEBI:8897 def: "A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica)." [] subset: 3_STAR synonym: "(-)-cis-rotenone" RELATED [ChemIDplus] synonym: "(-)-rotenone" RELATED [ChemIDplus] synonym: "(12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano[3,4-b]furano [2,3-h]chroman-6-one" RELATED [ChEBI] synonym: "(2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one" EXACT IUPAC_NAME [IUPAC] synonym: "5'beta-rotenone" RELATED [NIST_Chemistry_WebBook] synonym: "[2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one" RELATED [NIST_Chemistry_WebBook] synonym: "barbasco" RELATED [ChemIDplus] synonym: "canex" RELATED [ChemIDplus] synonym: "dactinol" RELATED [ChemIDplus] synonym: "Derris" RELATED [ChEBI] synonym: "noxfire" RELATED [ChemIDplus] synonym: "paraderil" RELATED [ChemIDplus] synonym: "Rotenone" EXACT [KEGG_COMPOUND] synonym: "tubatoxin" RELATED [ChemIDplus] xref: Beilstein:99070 {source="Beilstein"} xref: BPDB:587 xref: CAS:83-79-4 {source="ChemIDplus"} xref: CAS:83-79-4 {source="NIST Chemistry WebBook"} xref: CAS:83-79-4 {source="KEGG COMPOUND"} xref: DrugBank:DB11457 xref: FooDB:FDB012837 xref: HMDB:HMDB0034436 xref: KEGG:C07593 xref: KNApSAcK:C00002568 xref: LINCS:LSM-5260 xref: LIPID_MAPS_instance:LMPK12060007 {source="LIPID MAPS"} xref: Patent:CN102007944 xref: Patent:CN102090406 xref: PDBeChem:970 xref: PMID:14976342 {source="Europe PMC"} xref: PMID:15043430 {source="Europe PMC"} xref: PMID:15790535 {source="Europe PMC"} xref: PMID:17077549 {source="Europe PMC"} xref: PMID:19013527 {source="Europe PMC"} xref: PMID:32972993 {source="Europe PMC"} xref: PMID:33402167 {source="Europe PMC"} xref: PMID:33901458 {source="Europe PMC"} xref: PMID:33961406 {source="Europe PMC"} xref: Reaxys:99070 {source="Reaxys"} xref: VSDB:587 xref: Wikipedia:Rotenone is_a: CHEBI:38164 ! organic heteropentacyclic compound is_a: CHEBI:72581 ! rotenones relationship: RO:0000087 CHEBI:167183 ! has role piscicide relationship: RO:0000087 CHEBI:22917 ! has role phytogenic insecticide relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:38498 ! has role mitochondrial NADH:ubiquinone reductase inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H22O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JUVIOZPCNVVQFO-HBGVWJBISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "394.423" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "394.14164" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(CC2=C3O[C@]4([H])COC5=C(C=C(OC)C(OC)=C5)[C@]4([H])C(=O)C3=CC=C2O1)C(C)=C" xsd:string [Term] id: CHEBI:28240 name: dichloroacetate namespace: chebi_ontology alt_id: CHEBI:23694 def: "A monocarboxylic acid anion that is the conjugate base of dichloroacetic acid." [] subset: 3_STAR synonym: "dichloracetate" RELATED [ChemIDplus] synonym: "dichloroacetate" EXACT IUPAC_NAME [IUPAC] synonym: "dichloroacetate ion" RELATED [ChemIDplus] synonym: "dichloroacetic acid ion(1-)" RELATED [ChemIDplus] xref: Beilstein:3903873 {source="ChemIDplus"} xref: CAS:13425-80-4 {source="ChemIDplus"} xref: Gmelin:200685 {source="Gmelin"} xref: MetaCyc:CPD-9674 xref: PMID:21153705 {source="Europe PMC"} xref: Reaxys:3903873 {source="Reaxys"} xref: UM-BBD_compID:c0012 {source="UM-BBD"} is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: has_functional_parent CHEBI:30089 ! acetate relationship: is_conjugate_base_of CHEBI:36386 ! dichloroacetic acid relationship: RO:0000087 CHEBI:176497 ! has role geroprotector property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2HCl2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JXTHNDFMNIQAHM-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "127.93400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "126.93591" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)C(Cl)Cl" xsd:string [Term] id: CHEBI:28306 name: semicarbazide namespace: chebi_ontology alt_id: CHEBI:26644 alt_id: CHEBI:9102 def: "A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine." [] subset: 3_STAR synonym: "Aminoharnstoff" RELATED [ChEBI] synonym: "Aminourea" RELATED [KEGG_COMPOUND] synonym: "Carbamidsaeurehydrazid" RELATED [ChEBI] synonym: "Carbamoylhydrazine" RELATED [KEGG_COMPOUND] synonym: "carbamylhydrazine" RELATED [ChemIDplus] synonym: "carbazamide" RELATED [ChemIDplus] synonym: "Hydrazinecarboxamide" RELATED [KEGG_COMPOUND] synonym: "hydrazinecarboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "Semicarbazide" EXACT [KEGG_COMPOUND] synonym: "Semikarbazid" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:506319 {source="Beilstein"} xref: CAS:57-56-7 {source="KEGG COMPOUND"} xref: CAS:57-56-7 {source="ChemIDplus"} xref: CAS:57-56-7 {source="NIST Chemistry WebBook"} xref: Gmelin:100758 {source="Gmelin"} xref: KEGG:C02077 xref: MetaCyc:SEMICARBAZIDE xref: PMID:11958526 {source="Europe PMC"} xref: PMID:17499072 {source="Europe PMC"} xref: PMID:23194563 {source="Europe PMC"} xref: PMID:23683401 {source="Europe PMC"} xref: Reaxys:506319 {source="Reaxys"} xref: Wikipedia:Semicarbazide is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:35363 ! carbohydrazide is_a: CHEBI:47857 ! ureas is_a: CHEBI:64708 ! one-carbon compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH5N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH5N3O/c2-1(5)4-3/h3H2,(H3,2,4,5)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DUIOPKIIICUYRZ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "75.07002" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "75.04326" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NNC(N)=O" xsd:string [Term] id: CHEBI:28368 name: novobiocin namespace: chebi_ontology alt_id: CHEBI:25597 alt_id: CHEBI:44505 alt_id: CHEBI:7644 def: "A coumarin-derived antibiotic obtained from Streptomyces niveus." [] subset: 3_STAR synonym: "N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide" RELATED [ChEBI] synonym: "Novobiocin" EXACT [KEGG_COMPOUND] synonym: "novobiocina" RELATED INN [DrugBank] synonym: "novobiocine" RELATED INN [DrugBank] synonym: "novobiocinum" RELATED INN [DrugBank] xref: CAS:303-81-1 {source="ChemIDplus"} xref: CAS:303-81-1 {source="KEGG COMPOUND"} xref: Drug_Central:1974 {source="DrugCentral"} xref: DrugBank:DB01051 xref: HMDB:HMDB0015185 xref: KEGG:C05080 xref: KNApSAcK:C00002487 xref: LINCS:LSM-5910 xref: Patent:WO2012049521 xref: Patent:WO2012103487 xref: PDBeChem:NOV xref: PMID:17132020 {source="Europe PMC"} xref: PMID:18418407 {source="Europe PMC"} xref: PMID:19282394 {source="Europe PMC"} xref: PMID:19762445 {source="Europe PMC"} xref: PMID:20325309 {source="Europe PMC"} xref: PMID:21388139 {source="Europe PMC"} xref: PMID:22897434 {source="Europe PMC"} xref: PMID:26844397 {source="Europe PMC"} xref: PMID:26926630 {source="Europe PMC"} xref: PMID:27829510 {source="Europe PMC"} xref: PMID:27914946 {source="Europe PMC"} xref: PMID:28246042 {source="Europe PMC"} xref: PMID:28316592 {source="Europe PMC"} xref: PMID:9687383 {source="Europe PMC"} xref: Reaxys:1445842 {source="Reaxys"} is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:25698 ! ether is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:33853 ! phenols is_a: CHEBI:35313 ! hexoside is_a: CHEBI:37912 ! hydroxycoumarin is_a: CHEBI:63367 ! monosaccharide derivative relationship: is_conjugate_acid_of CHEBI:71339 ! novobiocin(1-) relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:62868 ! has role hepatoprotective agent relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C31H36N2O11" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YJQPYGGHQPGBLI-KGSXXDOSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "612.62430" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "612.23191" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C" xsd:string [Term] id: CHEBI:28417 name: gentamycin C namespace: chebi_ontology alt_id: CHEBI:14294 alt_id: CHEBI:24208 alt_id: CHEBI:5308 subset: 3_STAR synonym: "Gentamicin C" RELATED [KEGG_COMPOUND] xref: CAS:11097-82-8 {source="KEGG COMPOUND"} xref: KEGG:C01918 is_a: CHEBI:17833 ! gentamycin relationship: is_conjugate_base_of CHEBI:75616 ! gentamicin C(5+) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H37N5O7R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "447.527" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "447.26930" xsd:string [Term] id: CHEBI:28545 name: valinomycin namespace: chebi_ontology alt_id: CHEBI:27269 alt_id: CHEBI:66347 alt_id: CHEBI:9924 def: "A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains." [] subset: 3_STAR synonym: "(3R,6R,9S,12S,15R,18R,21S,24S,27R,30R,33S,36S)-3,6,9,15,18,21,27,30,33-nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone" EXACT IUPAC_NAME [IUPAC] synonym: "Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)" RELATED [ChemIDplus] synonym: "cyclo[-D-O-Val-D-Val-L-O-Ala-L-Val]3" RELATED [ChEBI] synonym: "Valinomycin" EXACT [KEGG_COMPOUND] xref: Beilstein:78657 {source="ChemIDplus"} xref: Beilstein:78657 {source="Beilstein"} xref: CAS:2001-95-8 {source="ChemIDplus"} xref: CAS:2001-95-8 {source="KEGG COMPOUND"} xref: KEGG:C06684 xref: PMID:10603383 {source="Europe PMC"} xref: PMID:18633285 {source="Europe PMC"} xref: PMID:19347893 {source="Europe PMC"} xref: PMID:22683555 {source="Europe PMC"} xref: PMID:7590182 {source="Europe PMC"} xref: Reaxys:78657 {source="Reaxys"} xref: Wikipedia:Valinomycin is_a: CHEBI:35213 ! cyclodepsipeptide is_a: CHEBI:51026 ! macrocycle relationship: RO:0000087 CHEBI:22587 ! has role antiviral agent relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite relationship: RO:0000087 CHEBI:88227 ! has role potassium ionophore property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C54H90N6O18" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FCFNRCROJUBPLU-DNDCDFAISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1111.32180" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1110.63116" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C" xsd:string [Term] id: CHEBI:28600 name: farnesol namespace: chebi_ontology alt_id: CHEBI:24013 alt_id: CHEBI:24014 alt_id: CHEBI:4978 def: "A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1." [] subset: 3_STAR synonym: "3,7,11-trimethyl-2,6,10-dodecatrien-1-ol" RELATED [ChemIDplus] synonym: "3,7,11-trimethyl-2,6,10-dodecatrienol" RELATED [NIST_Chemistry_WebBook] synonym: "3,7,11-trimethyldodeca-2,6,10-trien-1-ol" EXACT IUPAC_NAME [IUPAC] synonym: "Farnesol" EXACT [KEGG_COMPOUND] synonym: "farnesyl alcohol" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:1763926 {source="Beilstein"} xref: CAS:4602-84-0 {source="NIST Chemistry WebBook"} xref: CAS:4602-84-0 {source="ChemIDplus"} xref: CAS:4602-84-0 {source="KEGG COMPOUND"} xref: DrugBank:DB02509 xref: HMDB:HMDB0004305 xref: KEGG:C01493 xref: KNApSAcK:C00003132 xref: LINCS:LSM-5398 xref: PMID:17640272 {source="Europe PMC"} xref: PMID:19402910 {source="Europe PMC"} xref: PMID:23902158 {source="Europe PMC"} xref: PMID:24987733 {source="Europe PMC"} xref: Reaxys:1763926 {source="Reaxys"} is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:26199 ! polyprenol is_a: CHEBI:36757 ! farnesane sesquiterpenoid relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H26O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CRDAMVZIKSXKFV-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "222.36634" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "222.19837" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(CO)=C(C)CCC([H])=C(C)CCC=C(C)C" xsd:string [Term] id: CHEBI:28616 name: carbamic acid namespace: chebi_ontology alt_id: CHEBI:22504 alt_id: CHEBI:23002 alt_id: CHEBI:3386 alt_id: CHEBI:44573 def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." [] subset: 3_STAR synonym: "Aminoameisensaeure" RELATED [ChEBI] synonym: "Aminoformic acid" RELATED [KEGG_COMPOUND] synonym: "Carbamate" RELATED [KEGG_COMPOUND] synonym: "CARBAMIC ACID" EXACT [PDBeChem] synonym: "Carbamic acid" EXACT [KEGG_COMPOUND] synonym: "carbamic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Carbamidsaeure" RELATED [ChEBI] xref: Beilstein:1734754 {source="Beilstein"} xref: CAS:463-77-4 {source="KEGG COMPOUND"} xref: CAS:463-77-4 {source="ChemIDplus"} xref: DrugBank:DB04261 xref: Gmelin:130345 {source="Gmelin"} xref: KEGG:C01563 xref: PDBeChem:OUT xref: Wikipedia:Carbamic_acid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:64708 ! one-carbon compound relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "61.04006" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "61.01638" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(O)=O" xsd:string [Term] id: CHEBI:28659 name: phosphorus atom namespace: chebi_ontology alt_id: CHEBI:26080 alt_id: CHEBI:8168 subset: 3_STAR synonym: "15P" RELATED [IUPAC] synonym: "fosforo" RELATED [ChEBI] synonym: "P" RELATED [IUPAC] synonym: "P" RELATED [KEGG_COMPOUND] synonym: "Phosphor" RELATED [ChEBI] synonym: "phosphore" RELATED [ChEBI] synonym: "Phosphorus" RELATED [KEGG_COMPOUND] synonym: "phosphorus" EXACT IUPAC_NAME [IUPAC] synonym: "phosphorus" RELATED [ChEBI] xref: CAS:7723-14-0 {source="ChemIDplus"} xref: CAS:7723-14-0 {source="KEGG COMPOUND"} xref: Gmelin:16235 {source="Gmelin"} xref: KEGG:C06262 xref: WebElements:P is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OAICVXFJPJFONN-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "30.97376" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.97376" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[P]" xsd:string [Term] id: CHEBI:28669 name: bacitracin namespace: chebi_ontology alt_id: CHEBI:22684 alt_id: CHEBI:2970 def: "A mixture of at least nine closely related homodetic cyclic peptides produced by Bacillus subtilis and B. licheniformis, which is particularly active against Gram-positive bacteria." [] subset: 3_STAR synonym: "Baciim" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Bacitracin" EXACT [KEGG_COMPOUND] synonym: "bacitracin" RELATED INN [WHO_MedNet] synonym: "bacitracina" RELATED INN [WHO_MedNet] synonym: "bacitracine" RELATED INN [WHO_MedNet] synonym: "bacitracins" RELATED [ChEBI] synonym: "bacitracinum" RELATED INN [WHO_MedNet] xref: CAS:1405-87-4 {source="KEGG COMPOUND"} xref: CAS:1405-87-4 {source="ChemIDplus"} xref: DrugBank:DB00626 xref: KEGG:C01667 xref: KEGG:D00128 xref: PMID:22114686 {source="Europe PMC"} xref: Wikipedia:Bacitracin is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:35862 ! bacitracin A relationship: is_tautomer_of CHEBI:184381 ! bacitracin A zwitterion relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent property_value: http://purl.obolibrary.org/obo/chebi/formula "C63H98N14O14S" xsd:string [Term] id: CHEBI:28694 name: copper atom namespace: chebi_ontology alt_id: CHEBI:23376 alt_id: CHEBI:3874 subset: 3_STAR synonym: "29Cu" RELATED [IUPAC] synonym: "cobre" RELATED [ChEBI] synonym: "Copper" RELATED [KEGG_COMPOUND] synonym: "copper" EXACT IUPAC_NAME [IUPAC] synonym: "copper" RELATED [ChEBI] synonym: "Cu" RELATED [ChEBI] synonym: "Cu" RELATED [IUPAC] synonym: "cuivre" RELATED [ChEBI] synonym: "cuprum" RELATED [IUPAC] synonym: "Kupfer" RELATED [ChEBI] xref: CAS:7440-50-8 {source="ChemIDplus"} xref: CAS:7440-50-8 {source="KEGG COMPOUND"} xref: Gmelin:16269 {source="Gmelin"} xref: KEGG:C00070 xref: WebElements:Cu is_a: CHEBI:33366 ! copper group element atom is_a: CHEBI:88184 ! metal allergen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Cu" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cu" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RYGMFSIKBFXOCR-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "63.54600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.92960" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cu]" xsd:string [Term] id: CHEBI:28817 name: dodecane namespace: chebi_ontology alt_id: CHEBI:25464 alt_id: CHEBI:41713 alt_id: CHEBI:4675 def: "A straight-chain alkane with 12 carbon atoms. It has been isolated from the essential oils of various plants including Zingiber officinale (ginger)." [] subset: 3_STAR synonym: "Bihexyl" RELATED [HMDB] synonym: "CH3-[CH2]10-CH3" RELATED [IUPAC] synonym: "Dihexyl" RELATED [HMDB] synonym: "DODECANE" EXACT [PDBeChem] synonym: "Dodecane" EXACT [KEGG_COMPOUND] synonym: "dodecane" EXACT IUPAC_NAME [IUPAC] synonym: "dodecane" EXACT [UniProt] synonym: "Dodekan" RELATED [ChEBI] synonym: "n-Dodecane" RELATED [KEGG_COMPOUND] xref: Beilstein:1697175 {source="ChemIDplus"} xref: CAS:112-40-3 {source="ChemIDplus"} xref: CAS:112-40-3 {source="KEGG COMPOUND"} xref: CAS:112-40-3 {source="NIST Chemistry WebBook"} xref: DrugBank:DB02771 xref: Gmelin:201408 {source="Gmelin"} xref: HMDB:HMDB0031444 xref: KEGG:C08374 xref: KNApSAcK:C00001248 xref: LIPID_MAPS_instance:LMFA11000004 {source="LIPID MAPS"} xref: MetaCyc:CPD-9290 xref: PDBeChem:D12 xref: PMID:24493301 {source="Europe PMC"} xref: Reaxys:1697175 {source="Reaxys"} xref: Wikipedia:Dodecane is_a: CHEBI:18310 ! alkane relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H26" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H26/c1-3-5-7-9-11-12-10-8-6-4-2/h3-12H2,1-2H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SNRUBQQJIBEYMU-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "170.33484" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "170.20345" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCC" xsd:string [Term] id: CHEBI:28864 name: tobramycin namespace: chebi_ontology alt_id: CHEBI:19849 alt_id: CHEBI:45933 alt_id: CHEBI:9610 def: "A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring." [] subset: 3_STAR synonym: "(1S,2S,3R,4S,6R)-4,6-diamino-3-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "3'-Deoxykanamycin B" RELATED [KEGG_COMPOUND] synonym: "Nebramycin 6" RELATED [ChemIDplus] synonym: "Nebramycin factir 6" RELATED [KEGG_COMPOUND] synonym: "O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine" RELATED [ChemIDplus] synonym: "Tobracin (TN)" RELATED [KEGG_DRUG] synonym: "Tobramycin" EXACT [KEGG_COMPOUND] synonym: "Tobrex (TN)" RELATED [KEGG_DRUG] xref: CAS:32986-56-4 {source="ChemIDplus"} xref: CAS:32986-56-4 {source="KEGG COMPOUND"} xref: Drug_Central:2684 {source="DrugCentral"} xref: DrugBank:DB00684 xref: KEGG:C00397 xref: KEGG:D00063 xref: LINCS:LSM-6534 xref: PDBeChem:TOY xref: PMID:11000679 {source="Europe PMC"} xref: PMID:11072877 {source="Europe PMC"} xref: PMID:11459219 {source="Europe PMC"} xref: PMID:11478352 {source="Europe PMC"} xref: PMID:14961139 {source="Europe PMC"} xref: PMID:15813341 {source="Europe PMC"} xref: PMID:16205136 {source="Europe PMC"} xref: PMID:16239129 {source="Europe PMC"} xref: PMID:16478137 {source="Europe PMC"} xref: PMID:16650821 {source="Europe PMC"} xref: PMID:17150225 {source="Europe PMC"} xref: PMID:18331849 {source="Europe PMC"} xref: PMID:19072156 {source="Europe PMC"} xref: PMID:19220547 {source="Europe PMC"} xref: PMID:19340717 {source="Europe PMC"} xref: PMID:19465435 {source="Europe PMC"} xref: PMID:20000576 {source="Europe PMC"} xref: PMID:20884302 {source="Europe PMC"} xref: PMID:20938669 {source="Europe PMC"} xref: PMID:21275493 {source="Europe PMC"} xref: PMID:21343445 {source="Europe PMC"} xref: PMID:21357290 {source="Europe PMC"} xref: PMID:21396748 {source="Europe PMC"} xref: PMID:21414310 {source="Europe PMC"} xref: PMID:21429824 {source="Europe PMC"} xref: PMID:21438171 {source="Europe PMC"} xref: PMID:21530479 {source="Europe PMC"} xref: PMID:21592592 {source="Europe PMC"} xref: PMID:21726492 {source="Europe PMC"} xref: PMID:21756818 {source="Europe PMC"} xref: PMID:21796931 {source="Europe PMC"} xref: PMID:21815282 {source="Europe PMC"} xref: Reaxys:1357507 {source="Reaxys"} xref: Wikipedia:Tobramycin is_a: CHEBI:22479 ! amino cyclitol glycoside relationship: has_functional_parent CHEBI:28098 ! kanamycin B relationship: is_conjugate_base_of CHEBI:73678 ! tobramycin(5+) relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H37N5O9" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NLVFBUXFDBBNBW-PBSUHMDJSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "467.51450" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "467.25913" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O" xsd:string [Term] id: CHEBI:28866 name: tetracosanoic acid namespace: chebi_ontology alt_id: CHEBI:25467 alt_id: CHEBI:26892 alt_id: CHEBI:6458 def: "A C24 straight-chain saturated fatty acid." [] subset: 3_STAR synonym: "CH3-[CH2]22-COOH" RELATED [IUPAC] synonym: "Lignoceric acid" RELATED [KEGG_COMPOUND] synonym: "Lignozerinsaeure" RELATED [ChEBI] synonym: "n-tetracosanoic acid" RELATED [ChEBI] synonym: "tetracosanic acid" RELATED [ChEBI] synonym: "Tetracosanoic acid" EXACT [KEGG_COMPOUND] synonym: "tetracosanoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Tetracosansaeure" RELATED [ChEBI] synonym: "tetracosoic acid" RELATED [ChEBI] synonym: "tetraeicosanoic acid" RELATED [ChEBI] synonym: "tetraicosanoic acid" RELATED [ChEBI] xref: Beilstein:1728237 {source="Beilstein"} xref: CAS:557-59-5 {source="ChemIDplus"} xref: CAS:557-59-5 {source="KEGG COMPOUND"} xref: CAS:557-59-5 {source="NIST Chemistry WebBook"} xref: Gmelin:107095 {source="Gmelin"} xref: HMDB:HMDB0002003 xref: KEGG:C08320 xref: KNApSAcK:C00001223 xref: LIPID_MAPS_instance:LMFA01010024 {source="LIPID MAPS"} xref: MetaCyc:TETRACOSANOATE xref: PMID:21781003 {source="Europe PMC"} xref: PMID:23019902 {source="Europe PMC"} xref: PMID:23157011 {source="Europe PMC"} xref: PMID:23394615 {source="Europe PMC"} xref: PMID:23871298 {source="Europe PMC"} xref: PMID:24491713 {source="Europe PMC"} xref: PMID:3174658 {source="Europe PMC"} xref: Reaxys:1728237 {source="Reaxys"} xref: Wikipedia:Lignoceric_acid is_a: CHEBI:27283 ! very long-chain fatty acid is_a: CHEBI:39418 ! straight-chain saturated fatty acid relationship: is_conjugate_acid_of CHEBI:31014 ! tetracosanoate relationship: RO:0000087 CHEBI:27311 ! has role volatile oil component relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83146 ! has role Daphnia tenebrosa metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H48O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QZZGJDVWLFXDLK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "368.63670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "368.36543" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCCCCCCCCCCCCC(O)=O" xsd:string [Term] id: CHEBI:28868 name: fatty acid anion namespace: chebi_ontology alt_id: CHEBI:13634 alt_id: CHEBI:24022 alt_id: CHEBI:4985 def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." [] subset: 3_STAR synonym: "a fatty acid" RELATED [UniProt] synonym: "acido graso anionico" RELATED [ChEBI] synonym: "acidos grasos anionicos" RELATED [ChEBI] synonym: "Alkanate" RELATED [KEGG_COMPOUND] synonym: "anion de l'acide gras" RELATED [ChEBI] synonym: "Fatty acid anion" EXACT [KEGG_COMPOUND] synonym: "fatty acid anions" RELATED [ChEBI] synonym: "Fettsaeureanion" RELATED [ChEBI] synonym: "Fettsaeureanionen" RELATED [ChEBI] xref: KEGG:C02403 xref: PMID:18628202 {source="Europe PMC"} is_a: CHEBI:18059 ! lipid is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:35366 ! fatty acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.00950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string [Term] id: CHEBI:28909 name: iprodione namespace: chebi_ontology alt_id: CHEBI:24871 alt_id: CHEBI:8902 def: "An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide." [] subset: 3_STAR synonym: "3-(3,5-dichlorophenyl)-1-(1-methylethyl)carbamoylhydantoin" RELATED [NIST_Chemistry_WebBook] synonym: "3-(3,5-dichlorophenyl)-2,4-dioxo-N-(propan-2-yl)-imidazolidine-1-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide" RELATED [UM-BBD] synonym: "3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide" RELATED [ChemIDplus] synonym: "3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxoimidazolidine-1-carboxamide" RELATED [IUPAC] synonym: "3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide" RELATED [ChemIDplus] synonym: "3-(3,5-dichlorophenyl)hydantoin-1-carboxylic acid isopropylamide" RELATED [ChemIDplus] synonym: "Iprodione" EXACT [KEGG_COMPOUND] synonym: "Rovral" RELATED BRAND_NAME [ChEBI] synonym: "Rovral" RELATED [KEGG_COMPOUND] synonym: "Rovrol" RELATED [KEGG_COMPOUND] xref: Beilstein:895003 {source="Beilstein"} xref: CAS:36734-19-7 {source="KEGG COMPOUND"} xref: CAS:36734-19-7 {source="ChemIDplus"} xref: CAS:36734-19-7 {source="NIST Chemistry WebBook"} xref: HMDB:HMDB0031795 xref: KEGG:C11208 xref: Patent:CN103053579 xref: Patent:CN103392726 xref: Patent:DE2149923 xref: Patent:US3755350 xref: Pesticides:iprodione {source="Alan Wood's Pesticides"} xref: PMID:11451425 {source="Europe PMC"} xref: PMID:22115616 {source="Europe PMC"} xref: PMID:22262495 {source="Europe PMC"} xref: PPDB:403 xref: Reaxys:895003 {source="Reaxys"} xref: UM-BBD_compID:c0635 {source="UM-BBD"} xref: Wikipedia:Iprodione is_a: CHEBI:24628 ! imidazolidine-2,4-dione is_a: CHEBI:47857 ! ureas is_a: CHEBI:87068 ! imidazole fungicide is_a: CHEBI:87197 ! dichlorophenyl dicarboximide fungicide relationship: RO:0000087 CHEBI:25491 ! has role nematicide relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H13Cl2N3O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H13Cl2N3O3/c1-7(2)16-12(20)17-6-11(19)18(13(17)21)10-4-8(14)3-9(15)5-10/h3-5,7H,6H2,1-2H3,(H,16,20)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONUFESLQCSAYKA-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "330.16700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "329.03340" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)NC(=O)N1CC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1" xsd:string [Term] id: CHEBI:28915 name: fosfomycin namespace: chebi_ontology alt_id: CHEBI:24100 alt_id: CHEBI:42503 alt_id: CHEBI:8159 def: "A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus." [] subset: 3_STAR synonym: "(-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid" RELATED [ChemIDplus] synonym: "(1R,2S)-epoxypropylphosphonic acid" RELATED [MetaCyc] synonym: "(2R-cis)-(3-Methyloxiranyl)phosphonic acid" RELATED [ChemIDplus] synonym: "1R-cis-(1,2-epoxypropyl)phosphonic acid" RELATED [ChEBI] synonym: "[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid" EXACT IUPAC_NAME [IUPAC] synonym: "cis-(1R,2S)-epoxypropylphosphonic acid" RELATED [MetaCyc] synonym: "FCM" RELATED [KEGG_DRUG] synonym: "fosfomicina" RELATED INN [ChemIDplus] synonym: "FOSFOMYCIN" EXACT [PDBeChem] synonym: "fosfomycin" RELATED INN [KEGG_DRUG] synonym: "fosfomycine" RELATED INN [ChemIDplus] synonym: "fosfomycinum" RELATED INN [ChemIDplus] synonym: "L-cis-1,2-epoxypropylphosphonic acid" RELATED [MetaCyc] synonym: "Phosphomycin" RELATED [ChemIDplus] synonym: "phosphonemycin" RELATED [MetaCyc] synonym: "Phosphonomycin" RELATED [KEGG_COMPOUND] xref: CAS:23155-02-4 {source="ChemIDplus"} xref: CAS:23155-02-4 {source="KEGG COMPOUND"} xref: Drug_Central:1243 {source="DrugCentral"} xref: DrugBank:DB00828 xref: KEGG:C06454 xref: KEGG:D04253 xref: KNApSAcK:C00000789 xref: MetaCyc:CPD0-1113 xref: PDBeChem:FCN xref: PMID:105327 {source="Europe PMC"} xref: PMID:17124631 {source="Europe PMC"} xref: PMID:19308743 {source="Europe PMC"} xref: PMID:2660079 {source="Europe PMC"} xref: PMID:288976 {source="Europe PMC"} xref: PMID:3464490 {source="Europe PMC"} xref: PMID:3900889 {source="Europe PMC"} xref: PMID:488578 {source="Europe PMC"} xref: PMID:614140 {source="Europe PMC"} xref: PMID:6348659 {source="Europe PMC"} xref: PMID:6796449 {source="Europe PMC"} xref: PMID:7030849 {source="Europe PMC"} xref: PMID:7224844 {source="Europe PMC"} xref: PMID:740308 {source="Europe PMC"} xref: PMID:9309262 {source="Europe PMC"} xref: Reaxys:1680831 {source="Reaxys"} is_a: CHEBI:26069 ! phosphonic acids is_a: CHEBI:32955 ! epoxide relationship: has_functional_parent CHEBI:44976 ! phosphonic acid relationship: is_conjugate_acid_of CHEBI:62247 ! (1R,2S)-epoxypropylphosphonate(1-) relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:78379 ! has role EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7O4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YMDXZJFXQJVXBF-STHAYSLISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "138.05900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "138.00820" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H]1O[C@@H]1P(O)(O)=O" xsd:string [Term] id: CHEBI:28938 name: ammonium namespace: chebi_ontology alt_id: CHEBI:22534 alt_id: CHEBI:49783 alt_id: CHEBI:7435 def: "An onium cation obtained by protonation of ammonia." [] subset: 3_STAR synonym: "[NH4](+)" RELATED [MolBase] synonym: "ammonium" EXACT IUPAC_NAME [IUPAC] synonym: "ammonium" EXACT [ChEBI] synonym: "ammonium cation" RELATED [ChemIDplus] synonym: "ammonium ion" RELATED [PDBeChem] synonym: "Ammonium(1+)" RELATED [ChemIDplus] synonym: "azanium" EXACT IUPAC_NAME [IUPAC] synonym: "NH4(+)" RELATED [UniProt] synonym: "NH4(+)" RELATED [IUPAC] synonym: "NH4+" RELATED [KEGG_COMPOUND] xref: CAS:14798-03-9 {source="NIST Chemistry WebBook"} xref: CAS:14798-03-9 {source="ChemIDplus"} xref: Gmelin:84 {source="Gmelin"} xref: KEGG:C01342 xref: MetaCyc:AMMONIUM xref: MolBase:929 xref: PDBeChem:NH4 xref: PMID:11319011 {source="Europe PMC"} xref: PMID:11341317 {source="Europe PMC"} xref: PMID:12096804 {source="Europe PMC"} xref: PMID:14512268 {source="Europe PMC"} xref: PMID:14879753 {source="Europe PMC"} xref: PMID:16345391 {source="Europe PMC"} xref: PMID:16903292 {source="Europe PMC"} xref: PMID:17392693 {source="Europe PMC"} xref: PMID:18515490 {source="Europe PMC"} xref: PMID:19199063 {source="Europe PMC"} xref: PMID:19596600 {source="Europe PMC"} xref: PMID:19682559 {source="Europe PMC"} xref: PMID:19716251 {source="Europe PMC"} xref: PMID:21993530 {source="Europe PMC"} xref: PMID:22265469 {source="Europe PMC"} xref: PMID:22524020 {source="Europe PMC"} xref: PMID:22562341 {source="Europe PMC"} xref: PMID:22631217 {source="Europe PMC"} xref: Reaxys:16093784 {source="Reaxys"} xref: Wikipedia:Ammonium is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:50313 ! onium cation is_a: CHEBI:60242 ! monovalent inorganic cation relationship: is_conjugate_acid_of CHEBI:16134 ! ammonia relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H4N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3N/h1H3/p+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "18.03850" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.03383" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N+]([H])([H])[H]" xsd:string [Term] id: CHEBI:28963 name: amino sugar namespace: chebi_ontology alt_id: CHEBI:22481 alt_id: CHEBI:22530 alt_id: CHEBI:2662 def: "Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." [] subset: 3_STAR synonym: "amino sugars" RELATED [ChEBI] synonym: "aminosugar" RELATED [ChEBI] synonym: "Aminosugars" RELATED [KEGG_COMPOUND] xref: KEGG:C05383 xref: PMID:18424273 {source="Europe PMC"} xref: PMID:9056391 {source="Europe PMC"} is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:28965 name: dicarboxylic acid dianion namespace: chebi_ontology alt_id: CHEBI:13632 alt_id: CHEBI:23688 alt_id: CHEBI:23689 alt_id: CHEBI:38711 def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." [] subset: 3_STAR synonym: "a dicarboxylate" RELATED [UniProt] synonym: "dicarboxylate" RELATED [ChEBI] synonym: "dicarboxylates" RELATED [ChEBI] synonym: "dicarboxylic acid dianion" EXACT [ChEBI] synonym: "dicarboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:35693 ! dicarboxylic acid anion is_a: CHEBI:38716 ! carboxylic acid dianion property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2O4R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "88.019" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "87.97966" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[*]C([O-])=O" xsd:string [Term] id: CHEBI:28971 name: ampicillin namespace: chebi_ontology alt_id: CHEBI:22536 alt_id: CHEBI:2683 alt_id: CHEBI:40648 alt_id: CHEBI:45042 def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID" RELATED [PDBeChem] synonym: "(2S,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [PDBeChem] synonym: "6-(D-(2-amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid" RELATED [ChemIDplus] synonym: "6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "ABPC" RELATED [ChEBI] synonym: "aminobenzylpenicillin" RELATED [DrugBank] synonym: "AMP" RELATED [ChEBI] synonym: "ampicilina" RELATED INN [ChemIDplus] synonym: "Ampicillin" EXACT [KEGG_COMPOUND] synonym: "ampicillin" RELATED INN [ChemIDplus] synonym: "ampicillin acid" RELATED [DrugBank] synonym: "ampicillin anhydrous" RELATED [DrugBank] synonym: "ampicilline" RELATED INN [ChemIDplus] synonym: "ampicillinum" RELATED INN [ChemIDplus] synonym: "Anhydrous ampicillin" RELATED [KEGG_COMPOUND] synonym: "AP" RELATED [ChEBI] synonym: "D-(-)-6-(alpha-aminophenylacetamido)penicillanic acid" RELATED [ChemIDplus] synonym: "D-(-)-ampicillin" RELATED [ChemIDplus] xref: Beilstein:4300240 {source="Beilstein"} xref: CAS:69-53-4 {source="ChemIDplus"} xref: Drug_Central:198 {source="DrugCentral"} xref: DrugBank:DB00415 xref: HMDB:HMDB0014559 xref: KEGG:C06574 xref: KEGG:D00204 xref: LINCS:LSM-5761 xref: Patent:GB902703 xref: Patent:US2985648 xref: Patent:US3157640 xref: PDB:1H8S xref: PDBeChem:AIC xref: PDBeChem:PN1 xref: PMID:10930630 {source="Europe PMC"} xref: PMID:12562703 {source="Europe PMC"} xref: PMID:12569987 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:14139119 {source="Europe PMC"} xref: PMID:14455820 {source="Europe PMC"} xref: PMID:15768449 {source="Europe PMC"} xref: PMID:16033609 {source="Europe PMC"} xref: PMID:18611716 {source="Europe PMC"} xref: PMID:19967069 {source="Europe PMC"} xref: PMID:2083978 {source="Europe PMC"} xref: PMID:23568176 {source="Europe PMC"} xref: PMID:23861268 {source="Europe PMC"} xref: PMID:24474427 {source="Europe PMC"} xref: PMID:24666465 {source="Europe PMC"} xref: PMID:25998949 {source="Europe PMC"} xref: PMID:28543395 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:6176550 {source="Europe PMC"} xref: PMID:8020088 {source="Europe PMC"} xref: PMID:9433938 {source="Europe PMC"} xref: Reaxys:4300240 {source="Reaxys"} xref: VSDB:1849 xref: Wikipedia:Ampicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:50658 ! ampicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H19N3O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AVKUERGKIZMTKX-NJBDSQKTSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "349.40500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "349.10963" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O" xsd:string [Term] id: CHEBI:28976 name: carbonic acid namespace: chebi_ontology alt_id: CHEBI:13351 alt_id: CHEBI:23017 alt_id: CHEBI:23744 alt_id: CHEBI:3401 subset: 3_STAR synonym: "[CO(OH)2]" RELATED [IUPAC] synonym: "Carbonic acid" EXACT [KEGG_COMPOUND] synonym: "carbonic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Dihydrogen carbonate" RELATED [KEGG_COMPOUND] synonym: "dihydroxidooxidocarbon" EXACT IUPAC_NAME [IUPAC] synonym: "H2CO3" RELATED [KEGG_COMPOUND] synonym: "H2CO3" RELATED [IUPAC] synonym: "Koehlensaeure" RELATED [ChEBI] xref: CAS:463-79-6 {source="ChemIDplus"} xref: CAS:463-79-6 {source="KEGG COMPOUND"} xref: Gmelin:25554 {source="Gmelin"} xref: KEGG:C01353 xref: PDBeChem:CO3 is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36961 ! chalcocarbonic acid relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "62.02478" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.00039" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(O)=O" xsd:string [Term] id: CHEBI:29007 name: ceftriaxone namespace: chebi_ontology alt_id: CHEBI:23059 alt_id: CHEBI:3513 alt_id: CHEBI:446214 def: "A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "ceftriaxona" RELATED INN [ChemIDplus] synonym: "ceftriaxone" RELATED INN [KEGG_DRUG] synonym: "ceftriaxonum" RELATED INN [ChemIDplus] synonym: "rocephin" RELATED [ChEBI] xref: Beilstein:6495519 {source="Beilstein"} xref: CAS:73384-59-5 {source="ChemIDplus"} xref: CAS:73384-59-5 {source="KEGG COMPOUND"} xref: CAS:73384-59-5 {source="KEGG DRUG"} xref: Drug_Central:564 {source="DrugCentral"} xref: DrugBank:DB01212 xref: HMDB:HMDB0015343 xref: KEGG:C06683 xref: KEGG:D07659 xref: MetaCyc:CPD-12294 xref: Patent:GB2022090 xref: Patent:US4327210 xref: PMID:11067716 {source="Europe PMC"} xref: PMID:11285492 {source="Europe PMC"} xref: PMID:11431418 {source="Europe PMC"} xref: PMID:11432680 {source="Europe PMC"} xref: PMID:11529382 {source="Europe PMC"} xref: PMID:11605716 {source="Europe PMC"} xref: PMID:11642230 {source="Europe PMC"} xref: PMID:11760218 {source="Europe PMC"} xref: PMID:11815759 {source="Europe PMC"} xref: PMID:11856984 {source="Europe PMC"} xref: PMID:11875753 {source="Europe PMC"} xref: PMID:11985490 {source="Europe PMC"} xref: PMID:12146884 {source="Europe PMC"} xref: PMID:12426628 {source="Europe PMC"} xref: PMID:12569987 {source="Europe PMC"} xref: PMID:12711894 {source="Europe PMC"} xref: PMID:12797390 {source="Europe PMC"} xref: PMID:12830336 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:12868545 {source="Europe PMC"} xref: PMID:1384868 {source="Europe PMC"} xref: PMID:15091234 {source="Europe PMC"} xref: PMID:15106316 {source="Europe PMC"} xref: PMID:15225244 {source="Europe PMC"} xref: PMID:15499067 {source="Europe PMC"} xref: PMID:15828439 {source="Europe PMC"} xref: PMID:15846537 {source="Europe PMC"} xref: PMID:15880392 {source="Europe PMC"} xref: PMID:15886468 {source="Europe PMC"} xref: PMID:16082406 {source="Europe PMC"} xref: PMID:16118675 {source="Europe PMC"} xref: PMID:16161754 {source="Europe PMC"} xref: PMID:16185184 {source="Europe PMC"} xref: PMID:16602117 {source="Europe PMC"} xref: PMID:16640341 {source="ChEMBL"} xref: PMID:16734965 {source="Europe PMC"} xref: PMID:17129840 {source="Europe PMC"} xref: PMID:17173674 {source="Europe PMC"} xref: PMID:17216959 {source="Europe PMC"} xref: PMID:17226043 {source="Europe PMC"} xref: PMID:17347554 {source="Europe PMC"} xref: PMID:17367972 {source="Europe PMC"} xref: PMID:17592517 {source="Europe PMC"} xref: PMID:18246742 {source="Europe PMC"} xref: PMID:18473104 {source="Europe PMC"} xref: PMID:18484523 {source="Europe PMC"} xref: PMID:18611641 {source="Europe PMC"} xref: PMID:18676229 {source="Europe PMC"} xref: PMID:18773080 {source="Europe PMC"} xref: PMID:18977704 {source="Europe PMC"} xref: PMID:19008722 {source="Europe PMC"} xref: PMID:19367098 {source="Europe PMC"} xref: PMID:19423473 {source="Europe PMC"} xref: PMID:19496200 {source="Europe PMC"} xref: PMID:19625514 {source="Europe PMC"} xref: PMID:19649758 {source="Europe PMC"} xref: PMID:21425867 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:6495519 {source="Reaxys"} xref: Wikipedia:Ceftriaxone is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether is_a: CHEBI:38418 ! 1,3-thiazoles is_a: CHEBI:39410 ! 1,2,4-triazines relationship: is_conjugate_acid_of CHEBI:53658 ! ceftriaxone(1-) relationship: RO:0000087 CHEBI:35625 ! has role EC 3.5.2.6 (beta-lactamase) inhibitor relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H18N8O7S3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VAAUVRVFOQPIGI-SPQHTLEESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "554.58000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "554.04606" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(CSc3nc(=O)c(=O)[nH]n3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O" xsd:string [Term] id: CHEBI:29013 name: fusidic acid namespace: chebi_ontology alt_id: CHEBI:24133 alt_id: CHEBI:42742 alt_id: CHEBI:5201 def: "A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum." [] subset: 3_STAR synonym: "(2Z)-2-[(17Z)-16beta-acetoxy-3alpha,11alpha-dihydroxy-4alpha,8alpha,10,14beta-tetramethyl-5alpha,9beta,13alpha-gonan-17-ylidene]-6-methylhept-5-enoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "fucidic acid" RELATED [ChEBI] synonym: "Fucidin acid" RELATED [ChemIDplus] synonym: "Fusidic acid" EXACT [KEGG_COMPOUND] synonym: "Fusidine" RELATED [ChemIDplus] synonym: "Ramycin" RELATED [ChemIDplus] xref: Beilstein:2197692 {source="Beilstein"} xref: Beilstein:5672885 {source="Beilstein"} xref: CAS:6990-06-3 {source="ChemIDplus"} xref: Drug_Central:1261 {source="DrugCentral"} xref: DrugBank:DB02703 xref: HMDB:HMDB0015570 xref: KEGG:C06694 xref: KEGG:D04281 xref: KNApSAcK:C00023903 xref: LIPID_MAPS_instance:LMPR0106040001 {source="LIPID MAPS"} xref: MetaCyc:CPD0-1606 xref: PDBeChem:FUA xref: PMID:11412963 {source="Europe PMC"} xref: PMID:12937375 {source="Europe PMC"} xref: PMID:13899435 {source="Europe PMC"} xref: PMID:13996455 {source="Europe PMC"} xref: PMID:15843024 {source="Europe PMC"} xref: PMID:17082187 {source="Europe PMC"} xref: PMID:20797618 {source="Europe PMC"} xref: PMID:22066960 {source="Europe PMC"} xref: PMID:22100514 {source="Europe PMC"} xref: PMID:22197537 {source="Europe PMC"} xref: PMID:22290345 {source="Europe PMC"} xref: PMID:22308410 {source="Europe PMC"} xref: PMID:22354299 {source="Europe PMC"} xref: PMID:22612900 {source="Europe PMC"} xref: PMID:22645663 {source="Europe PMC"} xref: PMID:22888356 {source="Europe PMC"} xref: PMID:23102978 {source="Europe PMC"} xref: PMID:23114758 {source="Europe PMC"} xref: PMID:23147726 {source="Europe PMC"} xref: PMID:8624493 {source="Europe PMC"} xref: Reaxys:2197692 {source="Reaxys"} xref: VSDB:1776 xref: Wikipedia:Fusidic_acid is_a: CHEBI:19129 ! 11alpha-hydroxy steroid is_a: CHEBI:26761 ! steroid antibiotic is_a: CHEBI:35915 ! sterol ester is_a: CHEBI:36835 ! 3alpha-hydroxy steroid is_a: CHEBI:47891 ! steroid acid is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid relationship: has_parent_hydride CHEBI:35515 ! 5alpha-cholestane relationship: is_conjugate_acid_of CHEBI:71321 ! fusidate relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77194 ! has role EC 2.7.1.33 (pantothenate kinase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C31H48O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IECPWNUMDGFDKC-MZJAQBGESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "516.70920" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "516.34509" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\\C([C@H](C[C@]34C)OC(C)=O)=C(/CCC=C(C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C" xsd:string [Term] id: CHEBI:29036 name: copper(2+) namespace: chebi_ontology alt_id: CHEBI:20882 alt_id: CHEBI:23380 alt_id: CHEBI:49550 def: "An ion of copper carrying a double positive charge." [] subset: 3_STAR synonym: "COPPER (II) ION" RELATED [PDBeChem] synonym: "copper(2+)" EXACT IUPAC_NAME [IUPAC] synonym: "copper(2+) ion" EXACT IUPAC_NAME [IUPAC] synonym: "copper(II) cation" EXACT IUPAC_NAME [IUPAC] synonym: "copper(II) cation" RELATED [ChEBI] synonym: "copper, ion (Cu2+)" RELATED [ChemIDplus] synonym: "Cu(2+)" RELATED [UniProt] synonym: "Cu(II)" RELATED [ChEBI] synonym: "Cu2+" RELATED [ChEBI] synonym: "cupric ion" RELATED [ChEBI] xref: CAS:15158-11-9 {source="ChemIDplus"} xref: Gmelin:6855 {source="Gmelin"} xref: PDBeChem:CU xref: PMID:23900424 {source="Europe PMC"} xref: PMID:24168430 {source="Europe PMC"} xref: Reaxys:3587177 {source="Reaxys"} is_a: CHEBI:23378 ! copper cation is_a: CHEBI:30412 ! monoatomic dication is_a: CHEBI:60240 ! divalent metal cation property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Cu" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Cu/q+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JPVYNHNXODAKFH-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "63.54600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.92850" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cu++]" xsd:string [Term] id: CHEBI:29067 name: carboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13626 alt_id: CHEBI:13945 alt_id: CHEBI:23026 alt_id: CHEBI:58657 def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a carboxylate" RELATED [UniProt] synonym: "carboxylic acid anions" RELATED [ChEBI] synonym: "carboxylic anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.00950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string [Term] id: CHEBI:29101 name: sodium(1+) namespace: chebi_ontology alt_id: CHEBI:26717 alt_id: CHEBI:49766 alt_id: CHEBI:9175 def: "A monoatomic monocation obtained from sodium." [] subset: 3_STAR synonym: "Na(+)" RELATED [UniProt] synonym: "Na(+)" RELATED [IUPAC] synonym: "Na+" RELATED [KEGG_COMPOUND] synonym: "sodium cation" EXACT IUPAC_NAME [IUPAC] synonym: "SODIUM ION" RELATED [PDBeChem] synonym: "sodium(1+)" EXACT IUPAC_NAME [IUPAC] synonym: "sodium(1+) ion" EXACT IUPAC_NAME [IUPAC] synonym: "sodium(I) cation" EXACT IUPAC_NAME [IUPAC] xref: CAS:17341-25-2 {source="ChemIDplus"} xref: CAS:17341-25-2 {source="NIST Chemistry WebBook"} xref: Gmelin:15196 {source="Gmelin"} xref: KEGG:C01330 xref: PDBeChem:NA is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37246 ! elemental sodium is_a: CHEBI:60242 ! monovalent inorganic cation relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Na" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Na/q+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FKNQFGJONOIPTF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "22.98977" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "22.98922" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na+]" xsd:string [Term] id: CHEBI:29103 name: potassium(1+) namespace: chebi_ontology alt_id: CHEBI:26219 alt_id: CHEBI:49685 alt_id: CHEBI:8345 def: "A monoatomic monocation obtained from potassium." [] subset: 3_STAR synonym: "K(+)" RELATED [UniProt] synonym: "K(+)" RELATED [IUPAC] synonym: "K+" RELATED [KEGG_COMPOUND] synonym: "potassium cation" EXACT IUPAC_NAME [IUPAC] synonym: "POTASSIUM ION" RELATED [PDBeChem] synonym: "potassium(1+)" EXACT IUPAC_NAME [IUPAC] synonym: "potassium(1+) ion" EXACT IUPAC_NAME [IUPAC] synonym: "potassium(I) cation" EXACT IUPAC_NAME [IUPAC] xref: CAS:24203-36-9 {source="NIST Chemistry WebBook"} xref: Gmelin:15203 {source="Gmelin"} xref: KEGG:C00238 xref: KEGG:D08403 xref: PDBeChem:K is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37247 ! elemental potassium is_a: CHEBI:60242 ! monovalent inorganic cation relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "K" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/K/q+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NPYPAHLBTDXSSS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "39.09830" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "38.96316" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[K+]" xsd:string [Term] id: CHEBI:29192 name: hydrogenperoxide(1-) namespace: chebi_ontology subset: 3_STAR synonym: "[HO2](-)" RELATED [ChEBI] synonym: "dioxidanide" EXACT IUPAC_NAME [IUPAC] synonym: "HO2(-)" RELATED [IUPAC] synonym: "HOO anion" RELATED [NIST_Chemistry_WebBook] synonym: "HOO(-)" RELATED [ChEBI] synonym: "hydrogen(peroxide)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogendioxide(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogenperoxide(1-)" EXACT [IUPAC] xref: CAS:14691-59-9 {source="ChemIDplus"} xref: CAS:14691-59-9 {source="NIST Chemistry WebBook"} xref: Gmelin:507 {source="Gmelin"} is_a: CHEBI:33693 ! oxygen hydride relationship: is_conjugate_base_of CHEBI:16240 ! hydrogen peroxide property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O2/c1-2/h1-2H/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MHAJPDPJQMAIIY-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "33.00674" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.99820" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]O[O-]" xsd:string [Term] id: CHEBI:29214 name: sulfonic acid namespace: chebi_ontology subset: 3_STAR synonym: "[SHO2(OH)]" RELATED [IUPAC] synonym: "acide sulfonique" RELATED [ChEBI] synonym: "HSHO3" RELATED [IUPAC] synonym: "hydridohydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC] synonym: "sulfonic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Sulfonsaeure" RELATED [ChEBI] synonym: "sulphonic acid" RELATED [ChEBI] xref: Gmelin:1404640 {source="Gmelin"} is_a: CHEBI:33402 ! sulfur oxoacid relationship: is_conjugate_acid_of CHEBI:33543 ! sulfonate relationship: is_tautomer_of CHEBI:48854 ! sulfurous acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "82.08008" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.97247" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S(O)(=O)=O" xsd:string [Term] id: CHEBI:29256 name: thiol namespace: chebi_ontology alt_id: CHEBI:13443 alt_id: CHEBI:13696 alt_id: CHEBI:17366 alt_id: CHEBI:26969 alt_id: CHEBI:8766 alt_id: CHEBI:9556 def: "An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety." [] subset: 3_STAR synonym: "a thiol" RELATED [UniProt] synonym: "Mercaptan" RELATED [KEGG_COMPOUND] synonym: "mercaptans" RELATED [ChEBI] synonym: "Merkaptan" RELATED [ChEBI] synonym: "RSH" RELATED [IUPAC] synonym: "Thiol" EXACT [KEGG_COMPOUND] synonym: "thiols" EXACT IUPAC_NAME [IUPAC] synonym: "thiols" RELATED [ChEBI] xref: KEGG:C00145 xref: Wikipedia:Thiol is_a: CHEBI:33261 ! organosulfur compound relationship: has_part CHEBI:29917 ! thiol group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HSR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "33.07300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.97990" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "S[*]" xsd:string [Term] id: CHEBI:29258 name: dihydrogenphosphite namespace: chebi_ontology def: "A monovalent inorganic anion obtained by deprotonation of phosphorous acid." [] subset: 3_STAR synonym: "[PO(OH)2] (-)" RELATED [IUPAC] synonym: "dihydrogen phosphite" RELATED [ChEBI] synonym: "dihydrogen(trioxidophosphate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "dihydrogenphosphite" EXACT IUPAC_NAME [IUPAC] synonym: "dihydroxidooxidophosphate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "H2PO3(-)" RELATED [IUPAC] xref: Gmelin:558293 {source="Gmelin"} is_a: CHEBI:26045 ! phosphite ion is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:29259 ! hydrogenphosphite relationship: is_conjugate_base_of CHEBI:36361 ! phosphorous acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3P/c1-4(2)3/h1-2H/q-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BLBIZNCSZLTDPW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "80.98784" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.97470" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP([O-])O[H]" xsd:string [Term] id: CHEBI:29259 name: hydrogenphosphite namespace: chebi_ontology def: "A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid." [] subset: 3_STAR synonym: "[PO2(OH)](2-)" RELATED [IUPAC] synonym: "HPO3(2-)" RELATED [IUPAC] synonym: "hydrogen phosphite" RELATED [IUPAC] synonym: "hydrogen(trioxidophosphate)(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogenphosphite" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidodioxidophosphate(2-)" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:323302 {source="Gmelin"} is_a: CHEBI:26045 ! phosphite ion is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_acid_of CHEBI:45064 ! phosphite(3-) relationship: is_conjugate_base_of CHEBI:29258 ! dihydrogenphosphite property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/HO3P/c1-4(2)3/h1H/q-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GBHRVZIGDIUCJB-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "79.97990" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.96743" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP([O-])[O-]" xsd:string [Term] id: CHEBI:29277 name: dinitride(2-) namespace: chebi_ontology subset: 3_STAR synonym: "diazenediide" EXACT IUPAC_NAME [IUPAC] synonym: "dinitride(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "N2(2-)" RELATED [IUPAC] xref: Gmelin:1565041 {source="Gmelin"} is_a: CHEBI:33266 ! diatomic nitrogen relationship: is_conjugate_base_of CHEBI:30103 ! diazenide property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/N2/c1-2/q-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BZZJUZUZJRQHLZ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01348" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "28.00725" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[N-]=[N-]" xsd:string [Term] id: CHEBI:29281 name: alkyl sulfate namespace: chebi_ontology alt_id: CHEBI:13810 alt_id: CHEBI:22325 alt_id: CHEBI:2583 subset: 3_STAR synonym: "alkyl sulfates" RELATED [ChEBI] is_a: CHEBI:25704 ! organic sulfate is_a: CHEBI:26819 ! sulfuric ester relationship: is_conjugate_acid_of CHEBI:83414 ! alkyl sulfate(1-) [Term] id: CHEBI:29337 name: azanide namespace: chebi_ontology subset: 3_STAR synonym: "amide" EXACT IUPAC_NAME [IUPAC] synonym: "azanide" EXACT IUPAC_NAME [IUPAC] synonym: "dihydridonitrate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "NH2(-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-) relationship: is_conjugate_base_of CHEBI:16134 ! ammonia property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2N/h1H2/q-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HYGWNUKOUCZBND-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "16.02262" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01927" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N-][H]" xsd:string [Term] id: CHEBI:29340 name: hydridonitrate(2-) namespace: chebi_ontology def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." [] subset: 3_STAR synonym: "azanediide" EXACT IUPAC_NAME [IUPAC] synonym: "hydridonitrate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "imide" RELATED [IUPAC] synonym: "NH(2-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:29337 ! azanide property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HN" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/HN/h1H/q-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DZQYTNGKSBCIOE-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "15.01468" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[N--][H]" xsd:string [Term] id: CHEBI:29347 name: monocarboxylic acid amide namespace: chebi_ontology alt_id: CHEBI:13211 alt_id: CHEBI:22207 alt_id: CHEBI:25383 alt_id: CHEBI:6977 def: "A carboxamide derived from a monocarboxylic acid." [] subset: 3_STAR synonym: "monocarboxylic acid amides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "42.01680" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N([*])C([*])=O" xsd:string [Term] id: CHEBI:29369 name: peroxy group namespace: chebi_ontology subset: 3_STAR synonym: "-OO-" RELATED [IUPAC] synonym: "peroxy" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33246 ! inorganic group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "31.99880" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O(O*)*" xsd:string [Term] id: CHEBI:29534 name: avermectin B1a namespace: chebi_ontology subset: 3_STAR synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "abamectin component B1a" RELATED [ChemIDplus] synonym: "Avermectin B1a" EXACT [KEGG_COMPOUND] xref: Beilstein:3645625 {source="Beilstein"} xref: BPDB:8 xref: CAS:65195-55-3 {source="KEGG COMPOUND"} xref: CAS:65195-55-3 {source="ChemIDplus"} xref: KEGG:C11983 xref: LIPID_MAPS_instance:LMPK04000024 {source="LIPID MAPS"} xref: MetaCyc:CPD-12963 xref: VSDB:8 is_a: CHEBI:50344 ! avermectin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C48H72O14" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RRZXIRBKKLTSOM-XPNPUAGNSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "873.07690" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "872.49221" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H](C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](C\\C=C(C)\\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\\C=C\\C=C4/CO[C@@H]5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)C=C[C@@H]1C" xsd:string [Term] id: CHEBI:29537 name: avermectin B1b namespace: chebi_ontology subset: 3_STAR synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-6'-(propan-2-yl)-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside" RELATED [IUPAC] synonym: "abamectin component B1b" RELATED [ChemIDplus] synonym: "Avermectin B1b" EXACT [KEGG_COMPOUND] xref: Beilstein:8399072 {source="Beilstein"} xref: CAS:65195-56-4 {source="KEGG COMPOUND"} xref: CAS:65195-56-4 {source="ChemIDplus"} xref: KEGG:C11967 xref: LIPID_MAPS_instance:LMPK04000020 {source="LIPID MAPS"} xref: MetaCyc:CPD-12964 is_a: CHEBI:50344 ! avermectin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C47H70O14" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C47H70O14/c1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h11-14,16-18,24-25,27,29-30,32-44,48-49,51H,15,19-23H2,1-10H3/b12-11+,26-14+,31-13+/t25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZFUKERYTFURFGA-PVVXTEPVSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "859.05030" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "858.47656" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C\\C=C(C)\\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\\C=C\\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(O2)O[C@]([H])(C(C)C)[C@@H](C)C=C1)[C@]34O" xsd:string [Term] id: CHEBI:2955 name: azithromycin namespace: chebi_ontology alt_id: CHEBI:46596 def: "A macrolide antibiotic useful for the treatment of bacterial infections." [] subset: 3_STAR synonym: "(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one" RELATED [ChemIDplus] synonym: "Azenil" RELATED BRAND_NAME [DrugBank] synonym: "Azifast" RELATED BRAND_NAME [ChEBI] synonym: "Azigram" RELATED BRAND_NAME [ChEBI] synonym: "Azimakrol" RELATED BRAND_NAME [ChEBI] synonym: "azithromycine" RELATED INN [ChemIDplus] synonym: "azithromycinum" RELATED INN [ChemIDplus] synonym: "azitromicina" RELATED INN [WHO_MedNet] synonym: "Azitromin" RELATED BRAND_NAME [ChEBI] synonym: "Hemomycin" RELATED BRAND_NAME [DrugBank] synonym: "Zithromax" RELATED BRAND_NAME [DrugBank] synonym: "Zmax" RELATED BRAND_NAME [DrugBank] xref: Beilstein:5387583 {source="Beilstein"} xref: CAS:83905-01-5 {source="ChemIDplus"} xref: Drug_Central:276 {source="DrugCentral"} xref: DrugBank:DB00207 xref: HMDB:HMDB0014352 xref: KEGG:C06838 xref: KEGG:D07486 xref: LINCS:LSM-5821 xref: Patent:BE892357 xref: Patent:US4517359 xref: PDBeChem:ZIT xref: PMID:15143799 {source="Europe PMC"} xref: PMID:18253999 {source="Europe PMC"} xref: Reaxys:5387583 {source="Reaxys"} xref: Reaxys:8820027 {source="Reaxys"} xref: Wikipedia:Azithromycin is_a: CHEBI:25105 ! macrolide antibiotic relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C38H72N2O12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MQTOSJVFKKJCRP-BICOPXKESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "748.98450" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "748.50853" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O" xsd:string [Term] id: CHEBI:29687 name: teicoplanin namespace: chebi_ontology def: "A complex mixture of related natural products isolated from the fermentation broth of a strain of Actinoplanes teichomyceticus comprising five major components (teicoplanin A2-1 through A2-5), a hydrolysis component (teicoplanin A3-1), and four minor components (teicoplanin RS-1 through RS-4). An antibiotic with a similar spectrum of activity to vancomycin, it is used to treat serious Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis." [] subset: 3_STAR synonym: "antibiotic 8327A" RELATED [ChemIDplus] synonym: "Targocid" RELATED BRAND_NAME [KEGG_DRUG] synonym: "teicoplanin" RELATED INN [ChemIDplus] synonym: "teicoplanina" RELATED INN [ChemIDplus] synonym: "teicoplanine" RELATED INN [WHO_MedNet] synonym: "teicoplaninum" RELATED INN [ChemIDplus] xref: CAS:61036-62-2 {source="KEGG DRUG"} xref: CAS:61036-62-2 {source="ChemIDplus"} xref: DrugBank:DB06149 xref: KEGG:C15820 xref: KEGG:D02142 xref: PMID:1416858 {source="Europe PMC"} xref: PMID:24506456 {source="Europe PMC"} xref: PMID:24693468 {source="Europe PMC"} xref: PMID:25190719 {source="Europe PMC"} xref: PMID:25218156 {source="Europe PMC"} xref: PMID:25224001 {source="Europe PMC"} xref: PMID:25358800 {source="Europe PMC"} xref: PMID:25616054 {source="Europe PMC"} xref: PMID:25726436 {source="Europe PMC"} xref: Reaxys:8196734 {source="Reaxys"} xref: Wikipedia:Teicoplanin is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:34995 ! teicoplanin A2-1 relationship: has_part CHEBI:34996 ! teicoplanin A2-3 relationship: has_part CHEBI:34997 ! teicoplanin A2-4 relationship: has_part CHEBI:34998 ! teicoplanin A2-5 relationship: has_part CHEBI:34999 ! teicoplanin A3-1 relationship: has_part CHEBI:85251 ! teicoplanin A2-2 relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string [Term] id: CHEBI:29688 name: telithromycin namespace: chebi_ontology alt_id: CHEBI:46029 subset: 2_STAR synonym: "(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside" RELATED [PDBeChem] synonym: "HMR 3647" RELATED [DrugCentral] synonym: "HMR-3647" RELATED [KEGG_COMPOUND] synonym: "HMR3647" RELATED [KEGG_COMPOUND] synonym: "RU 66647" RELATED [DrugCentral] synonym: "RU-66647" RELATED [KEGG_COMPOUND] synonym: "RU66647" RELATED [KEGG_COMPOUND] synonym: "TELITHROMYCIN" EXACT [PDBeChem] synonym: "Telithromycin" EXACT [KEGG_COMPOUND] xref: CAS:191114-48-4 {source="KEGG COMPOUND"} xref: Drug_Central:2581 {source="DrugCentral"} xref: KEGG:C12009 xref: KEGG:D01078 xref: PDBeChem:TEL is_a: CHEBI:28963 ! amino sugar property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C43H65N5O10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29+,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LJVAJPDWBABPEJ-MMEUOAQYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "812.00390" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "811.47314" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@]12[C@](N(C(O1)=O)CCCCN3C=C(N=C3)C=4C=CC=NC4)([C@@H](C)C(=O)[C@H](C)C[C@](OC)(C)[C@@H]([C@H](C([C@](C(O[C@@H]2CC)=O)(C)[H])=O)C)O[C@]5([C@H](O)[C@@H](N(C)C)C[C@H](O5)C)[H])[H]" xsd:string [Term] id: CHEBI:29699 name: tunicamycin namespace: chebi_ontology def: "A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety." [] subset: 3_STAR synonym: "Tunicamycin" EXACT [KEGG_COMPOUND] xref: CAS:11089-65-9 {source="ChemIDplus"} xref: CAS:11089-65-9 {source="KEGG COMPOUND"} xref: KEGG:C12063 xref: PMID:11478581 {source="Europe PMC"} xref: PMID:11514096 {source="Europe PMC"} xref: PMID:11732194 {source="Europe PMC"} xref: PMID:11798249 {source="Europe PMC"} xref: PMID:12093793 {source="Europe PMC"} xref: PMID:12106388 {source="Europe PMC"} xref: PMID:12136966 {source="Europe PMC"} xref: PMID:12232600 {source="Europe PMC"} xref: PMID:12232799 {source="Europe PMC"} xref: PMID:12515321 {source="Europe PMC"} xref: PMID:160437 {source="Europe PMC"} xref: PMID:1624425 {source="Europe PMC"} xref: PMID:3018444 {source="Europe PMC"} xref: PMID:315774 {source="Europe PMC"} xref: PMID:34700340 {source="Europe PMC"} xref: PMID:34979291 {source="Europe PMC"} xref: PMID:35233582 {source="Europe PMC"} xref: PMID:35370192 {source="Europe PMC"} xref: PMID:4624615 {source="Europe PMC"} xref: PMID:4630978 {source="Europe PMC"} xref: PMID:5103138 {source="Europe PMC"} xref: PMID:5103535 {source="Europe PMC"} xref: PMID:5168706 {source="Europe PMC"} xref: PMID:6153524 {source="Europe PMC"} xref: PMID:6813319 {source="Europe PMC"} xref: PMID:6975776 {source="Europe PMC"} xref: PMID:6992777 {source="Europe PMC"} xref: PMID:701277 {source="Europe PMC"} xref: PMID:7142115 {source="Europe PMC"} xref: PMID:7144800 {source="Europe PMC"} xref: PMID:7766032 {source="Europe PMC"} xref: Wikipedia:Tunicamycin is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:64228 ! tunicamycin A0 relationship: has_part CHEBI:64245 ! tunicamycin A1 relationship: has_part CHEBI:64246 ! tunicamycin A2 relationship: has_part CHEBI:64248 ! tunicamycin B1 relationship: has_part CHEBI:64250 ! tunicamycin B2 relationship: has_part CHEBI:64255 ! tunicamycin B3 relationship: has_part CHEBI:64256 ! tunicamycin C1 relationship: has_part CHEBI:64257 ! tunicamycin C2 relationship: has_part CHEBI:64271 ! tunicamycin D1 relationship: has_part CHEBI:64272 ! tunicamycin D2 relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:64237 ! has role EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C25H38N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "650.587" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "650.22828" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](OC2O[C@H]([*]O)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC([*])=O)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:29700 name: tylactone namespace: chebi_ontology alt_id: CHEBI:76805 def: "A 16-membererd macrolide that is the aglycone of the antibiotic 5-O-beta-D-mycaminosyltylactone." [] subset: 3_STAR synonym: "(4R,5S,6S,7S,9R,11E,13E,15S,16R)-7,16-diethyl-4,6-dihydroxy-5,9,13,15-tetramethyloxacyclohexadeca-11,13-diene-2,10-dione" EXACT IUPAC_NAME [IUPAC] synonym: "20-Deoxo-12,13-desepoxy-12,13-dehydrorosaranolide" RELATED [ChemIDplus] synonym: "20-deoxo-23-deoxytylonolide" RELATED [ChemIDplus] synonym: "20-Dsdr" RELATED [ChemIDplus] synonym: "Protylonolide" RELATED [KEGG_COMPOUND] synonym: "Tylactone" EXACT [KEGG_COMPOUND] synonym: "tylactone" EXACT [UniProt] xref: CAS:74758-60-4 {source="ChemIDplus"} xref: CAS:74758-60-4 {source="KEGG COMPOUND"} xref: KEGG:C12000 xref: MetaCyc:CPD-15948 {source="SUBMITTER"} xref: PMID:3733529 {source="Europe PMC"} xref: PMID:6511663 {source="Europe PMC"} xref: PMID:6735923 {source="Europe PMC"} xref: PMID:6833128 {source="Europe PMC"} xref: PMID:7118724 {source="Europe PMC"} xref: Reaxys:5765520 {source="Reaxys"} is_a: CHEBI:23824 ! diol is_a: CHEBI:25106 ! macrolide is_a: CHEBI:51689 ! enone relationship: RO:0000087 CHEBI:25212 ! has role metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H38O5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H38O5/c1-7-18-12-15(4)19(24)10-9-14(3)11-16(5)21(8-2)28-22(26)13-20(25)17(6)23(18)27/h9-11,15-18,20-21,23,25,27H,7-8,12-13H2,1-6H3/b10-9+,14-11+/t15-,16+,17+,18+,20-,21-,23-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YJSXTLYNFBFHAT-HJOMEYPASA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "394.54480" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "394.27192" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1C[C@@H](C)C(=O)\\C=C\\C(\\C)=C\\[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O" xsd:string [Term] id: CHEBI:29785 name: nitro group namespace: chebi_ontology subset: 3_STAR synonym: "-NO2" RELATED [IUPAC] synonym: "nitro" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33246 ! inorganic group is_a: CHEBI:51144 ! nitrogen group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "46.00550" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "45.99290" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*[N+](=O)[O-]" xsd:string [Term] id: CHEBI:29917 name: thiol group namespace: chebi_ontology alt_id: CHEBI:26821 alt_id: CHEBI:29916 subset: 3_STAR synonym: "-SH" RELATED [IUPAC] synonym: "HS-" RELATED [IUPAC] synonym: "mercapto group" RELATED [ChEBI] synonym: "Mercaptogruppe" RELATED [ChEBI] synonym: "Merkaptogruppe" RELATED [ChEBI] synonym: "sulfanyl" EXACT IUPAC_NAME [IUPAC] synonym: "sulfhydryl group" RELATED [ChEBI] synonym: "Sulfhydrylgruppe" RELATED [ChEBI] synonym: "sulphydryl group" RELATED [ChEBI] synonym: "thiol" EXACT IUPAC_NAME [IUPAC] synonym: "thiol group" EXACT [UniProt] synonym: "Thiolgruppe" RELATED [ChEBI] is_a: CHEBI:33246 ! inorganic group relationship: is_substituent_group_from CHEBI:16136 ! hydrogen sulfide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HS" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "33.074" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.97990" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*S[H]" xsd:string [Term] id: CHEBI:29919 name: hydrosulfide namespace: chebi_ontology subset: 3_STAR synonym: "HS anion" RELATED [NIST_Chemistry_WebBook] synonym: "HS(-)" RELATED [IUPAC] synonym: "hydrogen sulfide" RELATED [UniProt] synonym: "hydrogen(sulfide)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrosulfide" EXACT [IUPAC] synonym: "sulfanide" EXACT IUPAC_NAME [IUPAC] xref: CAS:15035-72-0 {source="ChemIDplus"} xref: CAS:15035-72-0 {source="NIST Chemistry WebBook"} xref: Gmelin:24766 {source="Gmelin"} is_a: CHEBI:33535 ! sulfur hydride relationship: is_conjugate_acid_of CHEBI:15138 ! sulfide(2-) relationship: is_conjugate_base_of CHEBI:16136 ! hydrogen sulfide relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HS" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2S/h1H2/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RWSOTUBLDIXVET-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "33.07394" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.98044" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S-][H]" xsd:string [Term] id: CHEBI:29922 name: sulfo group namespace: chebi_ontology subset: 3_STAR synonym: "-S(O)2(OH)" RELATED [IUPAC] synonym: "hydroxydioxo-lambda(6)-sulfanyl" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxysulfonyl" EXACT IUPAC_NAME [IUPAC] synonym: "sulfo" EXACT IUPAC_NAME [IUPAC] synonym: "SULFO GROUP" EXACT [PDBeChem] xref: PDBeChem:SFO is_a: CHEBI:33246 ! inorganic group relationship: is_substituent_group_from CHEBI:29214 ! sulfonic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96464" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "S(=O)(O)(*)=O" xsd:string [Term] id: CHEBI:30089 name: acetate namespace: chebi_ontology alt_id: CHEBI:13704 alt_id: CHEBI:22165 alt_id: CHEBI:40480 def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." [] subset: 3_STAR synonym: "acetate" EXACT [UniProt] synonym: "acetate" EXACT IUPAC_NAME [IUPAC] synonym: "ACETATE ION" RELATED [PDBeChem] synonym: "acetic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Azetat" RELATED [ChEBI] synonym: "CH3-COO(-)" RELATED [IUPAC] synonym: "Ethanoat" RELATED [ChEBI] synonym: "ethanoate" RELATED [ChEBI] synonym: "MeCO2 anion" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:1901470 {source="Beilstein"} xref: CAS:71-50-1 {source="ChemIDplus"} xref: CAS:71-50-1 {source="NIST Chemistry WebBook"} xref: DrugBank:DB03166 xref: Gmelin:1379 {source="Gmelin"} xref: KEGG:C00033 xref: MetaCyc:ACET xref: PDBeChem:ACT xref: PMID:17190852 {source="Europe PMC"} xref: PMID:22211106 {source="Europe PMC"} xref: PMID:22371380 {source="Europe PMC"} xref: Reaxys:1901470 {source="Reaxys"} xref: UM-BBD_compID:c0050 {source="UM-BBD"} xref: Wikipedia:Acetate is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:15366 ! acetic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QTBSBXVTEAMEQO-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "59.04402" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.01385" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC([O-])=O" xsd:string [Term] id: CHEBI:30096 name: diazene namespace: chebi_ontology subset: 3_STAR synonym: "diazene" EXACT IUPAC_NAME [IUPAC] synonym: "Diimide" RELATED [NIST_Chemistry_WebBook] synonym: "HN=NH" RELATED [IUPAC] xref: CAS:3618-05-1 {source="NIST Chemistry WebBook"} xref: CAS:3618-05-1 {source="ChemIDplus"} xref: KEGG:C05360 is_a: CHEBI:35106 ! nitrogen hydride relationship: is_conjugate_acid_of CHEBI:30103 ! diazenide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2N2/c1-2/h1-2H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RAABOESOVLLHRU-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "30.02936" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.02180" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N=N" xsd:string [Term] id: CHEBI:30103 name: diazenide namespace: chebi_ontology subset: 3_STAR synonym: "diazenide" EXACT IUPAC_NAME [IUPAC] synonym: "N=NH(-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride relationship: is_conjugate_acid_of CHEBI:29277 ! dinitride(2-) relationship: is_conjugate_base_of CHEBI:30096 ! diazene property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HN2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/HN2/c1-2/h1H/q-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XSCXGOPPNHTWEF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "29.02142" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.01452" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N=[N-]" xsd:string [Term] id: CHEBI:30106 name: azo group namespace: chebi_ontology subset: 3_STAR synonym: "-N=N-" RELATED [IUPAC] synonym: "azo" RELATED [IUPAC] synonym: "diazene-1,2-diyl" RELATED [IUPAC] synonym: "diazenediyl" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33246 ! inorganic group relationship: is_substituent_group_from CHEBI:30096 ! diazene property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01348" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "28.00615" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(=N/*)\\*" xsd:string [Term] id: CHEBI:3015 name: benomyl namespace: chebi_ontology def: "A member of the class of benzimidazoles that is the methyl ester of [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamic acid. A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops." [] subset: 3_STAR synonym: "1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat" RELATED [ChemIDplus] synonym: "1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester" RELATED [ChemIDplus] synonym: "1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol" RELATED [ChemIDplus] synonym: "Benlate" RELATED [KEGG_COMPOUND] synonym: "Benomyl" EXACT [KEGG_COMPOUND] synonym: "Methyl 1-(butylamino)carbonyl-1H-benzimidazol-2-ylcarbamate" RELATED [HMDB] synonym: "Methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate" RELATED [HMDB] synonym: "methyl [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamate" EXACT IUPAC_NAME [IUPAC] synonym: "Methyl N-(1-butylcarbamoyl-2-benzimidazole)carbamate" RELATED [HMDB] xref: Beilstein:825455 {source="Beilstein"} xref: CAS:17804-35-2 {source="ChemIDplus"} xref: CAS:17804-35-2 {source="NIST Chemistry WebBook"} xref: CAS:17804-35-2 {source="KEGG COMPOUND"} xref: HMDB:HMDB0031767 xref: KEGG:C10896 xref: Pesticides:benomyl {source="Alan Wood's Pesticides"} xref: PMID:15813220 {source="Europe PMC"} xref: PMID:16903866 {source="Europe PMC"} xref: PMID:19049291 {source="Europe PMC"} xref: PMID:24693254 {source="Europe PMC"} xref: PMID:24782104 {source="Europe PMC"} xref: PMID:25045800 {source="Europe PMC"} xref: PMID:25104429 {source="Europe PMC"} xref: PMID:25145128 {source="Europe PMC"} xref: PPDB:66 xref: Reaxys:825455 {source="Reaxys"} xref: Wikipedia:Benomyl is_a: CHEBI:62733 ! aromatic amide is_a: CHEBI:87036 ! benzimidazole fungicide is_a: CHEBI:87064 ! benzimidazolylcarbamate fungicide relationship: RO:0000087 CHEBI:22153 ! has role acaricide relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug relationship: RO:0000087 CHEBI:61951 ! has role microtubule-destabilising agent relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H18N4O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RIOXQFHNBCKOKP-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "290.31770" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "290.13789" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCNC(=O)n1c(NC(=O)OC)nc2ccccc12" xsd:string [Term] id: CHEBI:30256 name: thiocarbonyl group namespace: chebi_ontology subset: 3_STAR synonym: ">C=S" RELATED [IUPAC] synonym: "carbonothioyl" EXACT IUPAC_NAME [IUPAC] synonym: "thiocarbonyl" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51422 ! organodiyl group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CS" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.07670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.97207" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "S=C(*)*" xsd:string [Term] id: CHEBI:30347 name: ethylenediamine namespace: chebi_ontology def: "An alkane-alpha,omega-diamine in which the alkane is ethane." [] subset: 3_STAR synonym: "1,2-ethanediamine" RELATED [IUPAC] synonym: "en" RELATED [IUPAC] synonym: "ethane-1,2-diamine" EXACT IUPAC_NAME [IUPAC] synonym: "ethylenediamine" EXACT [IUPAC] xref: Beilstein:605263 {source="Beilstein"} xref: CAS:107-15-3 {source="NIST Chemistry WebBook"} xref: CAS:107-15-3 {source="ChemIDplus"} xref: Gmelin:1098 {source="Gmelin"} xref: HMDB:HMDB0031225 xref: KEGG:D01114 xref: MetaCyc:CPD-3682 xref: PDBeChem:EDN xref: PMID:21616561 {source="Europe PMC"} xref: PMID:3692019 {source="Europe PMC"} xref: PMID:7070713 {source="Europe PMC"} xref: Reaxys:605263 {source="Reaxys"} xref: Wikipedia:Ethylenediamine is_a: CHEBI:35411 ! alkane-alpha,omega-diamine relationship: has_parent_hydride CHEBI:42266 ! ethane relationship: RO:0000087 CHEBI:51373 ! has role GABA agonist property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H8N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H8N2/c3-1-2-4/h1-4H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PIICEJLVQHRZGT-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.09840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.06875" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCN" xsd:string [Term] id: CHEBI:30412 name: monoatomic dication namespace: chebi_ontology alt_id: CHEBI:23856 alt_id: CHEBI:4665 subset: 3_STAR synonym: "Divalent cation" RELATED [KEGG_COMPOUND] synonym: "divalent inorganic cations" RELATED [ChEBI] synonym: "monoatomic dications" RELATED [ChEBI] xref: KEGG:C00572 is_a: CHEBI:23906 ! monoatomic cation property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*++]" xsd:string [Term] id: CHEBI:30488 name: sulfonium namespace: chebi_ontology subset: 3_STAR synonym: "[SH3](+)" RELATED [ChEBI] synonym: "H3S(+)" RELATED [IUPAC] synonym: "H3S+" RELATED [NIST_Chemistry_WebBook] synonym: "sulfanium" EXACT IUPAC_NAME [IUPAC] synonym: "sulfonium" EXACT IUPAC_NAME [IUPAC] synonym: "sulphonium" RELATED [ChEBI] synonym: "trihydridosulfur(1+)" EXACT IUPAC_NAME [IUPAC] xref: CAS:18155-21-0 {source="NIST Chemistry WebBook"} xref: CAS:18155-21-0 {source="ChemIDplus"} xref: Gmelin:307 {source="Gmelin"} is_a: CHEBI:26830 ! sulfonium compound is_a: CHEBI:33535 ! sulfur hydride is_a: CHEBI:50313 ! onium cation relationship: is_conjugate_acid_of CHEBI:16136 ! hydrogen sulfide property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2S/h1H2/p+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RWSOTUBLDIXVET-UHFFFAOYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "35.08982" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.99500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][S+]([H])[H]" xsd:string [Term] id: CHEBI:30746 name: benzoic acid namespace: chebi_ontology alt_id: CHEBI:22722 alt_id: CHEBI:3029 alt_id: CHEBI:41051 def: "A compound comprising a benzene ring core carrying a carboxylic acid substituent." [] subset: 3_STAR synonym: "acide benzoique" RELATED [ChEBI] synonym: "Aromatic carboxylic acid" RELATED [KEGG_COMPOUND] synonym: "Benzenecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "Benzeneformic acid" RELATED [HMDB] synonym: "Benzenemethanoic acid" RELATED [HMDB] synonym: "Benzoesaeure" RELATED [ChEBI] synonym: "BENZOIC ACID" EXACT [PDBeChem] synonym: "Benzoic acid" EXACT [KEGG_COMPOUND] synonym: "benzoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Dracylic acid" RELATED [KEGG_COMPOUND] synonym: "E210" RELATED [ChEBI] synonym: "Phenylcarboxylic acid" RELATED [HMDB] synonym: "Phenylformic acid" RELATED [KEGG_COMPOUND] xref: Beilstein:636131 {source="Beilstein"} xref: CAS:65-85-0 {source="KEGG COMPOUND"} xref: CAS:65-85-0 {source="NIST Chemistry WebBook"} xref: CAS:65-85-0 {source="ChemIDplus"} xref: Drug_Central:4664 {source="DrugCentral"} xref: DrugBank:DB03793 xref: Gmelin:2946 {source="Gmelin"} xref: HMDB:HMDB0001870 xref: KEGG:C00180 xref: KEGG:C00539 xref: KEGG:D00038 xref: KNApSAcK:C00000207 xref: LINCS:LSM-37118 xref: MetaCyc:BENZOATE xref: PDBeChem:BEZ xref: PMID:16728954 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:18314336 {source="Europe PMC"} xref: PPDB:1475 xref: Reaxys:636131 {source="Reaxys"} xref: Wikipedia:Benzoic_Acid xref: YMDB:YMDB02301 is_a: CHEBI:22723 ! benzoic acids relationship: is_conjugate_acid_of CHEBI:16150 ! benzoate relationship: RO:0000087 CHEBI:64996 ! has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor relationship: RO:0000087 CHEBI:65001 ! has role EC 3.1.1.3 (triacylglycerol lipase) inhibitor relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WPYMKLBDIGXBTP-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "122.12130" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "122.03678" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1ccccc1" xsd:string [Term] id: CHEBI:30751 name: formic acid namespace: chebi_ontology alt_id: CHEBI:24082 alt_id: CHEBI:42460 alt_id: CHEBI:5145 def: "The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects." [] subset: 3_STAR synonym: "Acide formique" RELATED [ChemIDplus] synonym: "Ameisensaeure" RELATED [ChemIDplus] synonym: "aminic acid" RELATED [ChemIDplus] synonym: "bilorin" RELATED [ChemIDplus] synonym: "FORMIC ACID" EXACT [PDBeChem] synonym: "Formic acid" EXACT [KEGG_COMPOUND] synonym: "formic acid" EXACT IUPAC_NAME [IUPAC] synonym: "formylic acid" RELATED [ChemIDplus] synonym: "H-COOH" RELATED [IUPAC] synonym: "HCO2H" RELATED [ChEBI] synonym: "HCOOH" RELATED [NIST_Chemistry_WebBook] synonym: "hydrogen carboxylic acid" RELATED [ChemIDplus] synonym: "Methanoic acid" RELATED [KEGG_COMPOUND] synonym: "methoic acid" RELATED [ChEBI] xref: Beilstein:1209246 {source="Beilstein"} xref: BPDB:1749 xref: CAS:64-18-6 {source="NIST Chemistry WebBook"} xref: CAS:64-18-6 {source="ChemIDplus"} xref: CAS:64-18-6 {source="KEGG COMPOUND"} xref: DrugBank:DB01942 xref: Gmelin:1008 {source="Gmelin"} xref: HMDB:HMDB0000142 xref: KEGG:C00058 xref: KNApSAcK:C00001182 xref: LIPID_MAPS_instance:LMFA01010040 {source="LIPID MAPS"} xref: MetaCyc:FORMATE xref: Patent:CN101481304 xref: PDBeChem:FMT xref: PMID:12591956 {source="Europe PMC"} xref: PMID:14637377 {source="Europe PMC"} xref: PMID:15811469 {source="Europe PMC"} xref: PMID:16120414 {source="Europe PMC"} xref: PMID:16185830 {source="Europe PMC"} xref: PMID:16222862 {source="Europe PMC"} xref: PMID:16230297 {source="Europe PMC"} xref: PMID:16445901 {source="Europe PMC"} xref: PMID:16465784 {source="Europe PMC"} xref: PMID:18034701 {source="Europe PMC"} xref: PMID:18397576 {source="Europe PMC"} xref: PMID:22080171 {source="Europe PMC"} xref: PMID:22280475 {source="Europe PMC"} xref: PMID:22304812 {source="Europe PMC"} xref: PMID:22385261 {source="Europe PMC"} xref: PMID:22447125 {source="Europe PMC"} xref: PMID:22483350 {source="Europe PMC"} xref: PMID:22499553 {source="Europe PMC"} xref: PMID:22540994 {source="Europe PMC"} xref: PMID:22606986 {source="Europe PMC"} xref: PMID:22622393 {source="Europe PMC"} xref: PMID:3946945 {source="Europe PMC"} xref: PMID:7361809 {source="Europe PMC"} xref: Reaxys:1209246 {source="Reaxys"} xref: Wikipedia:Formic_acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:15740 ! formate relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:48356 ! has role protic solvent relationship: RO:0000087 CHEBI:74783 ! has role astringent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDAGIHXWWSANSR-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "46.02538" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "46.00548" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(O)=O" xsd:string [Term] id: CHEBI:30762 name: salicylate namespace: chebi_ontology alt_id: CHEBI:15061 alt_id: CHEBI:26595 def: "A monohydroxybenzoate that is the conjugate base of salicylic acid." [] subset: 3_STAR synonym: "2-hydroxybenzoate" EXACT IUPAC_NAME [IUPAC] synonym: "2-hydroxybenzoic acid ion(1-)" RELATED [ChemIDplus] synonym: "o-hydroxybenzoate" RELATED [ChemIDplus] synonym: "sal" RELATED [IUPAC] synonym: "Salicylate" EXACT [KEGG_COMPOUND] synonym: "salicylate" EXACT [UniProt] xref: Beilstein:3605209 {source="Beilstein"} xref: CAS:63-36-5 {source="ChemIDplus"} xref: Gmelin:3417 {source="Gmelin"} xref: KEGG:C00805 xref: PMID:16669002 {source="Europe PMC"} xref: PMID:16934829 {source="Europe PMC"} xref: Reaxys:3605209 {source="Reaxys"} xref: UM-BBD_compID:c0043 {source="UM-BBD"} is_a: CHEBI:25388 ! monohydroxybenzoate relationship: is_conjugate_base_of CHEBI:16914 ! salicylic acid relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H5O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YGSDEFSMJLZEOE-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "137.11280" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "137.02442" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Oc1ccccc1C([O-])=O" xsd:string [Term] id: CHEBI:30802 name: isophthalic acid namespace: chebi_ontology def: "A benzenedicarboxylic acid that is benzene substituted by carboxy groups at position 1 and 3. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and terephthalic acids." [] subset: 3_STAR synonym: "benzene-1,3-dicarboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "IPA" RELATED [NIST_Chemistry_WebBook] synonym: "m-benzenedicarboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "meta-benzenedicarboxylic acid" RELATED [ChEBI] xref: Beilstein:1909332 {source="Beilstein"} xref: CAS:121-91-5 {source="NIST Chemistry WebBook"} xref: CAS:121-91-5 {source="ChemIDplus"} xref: Gmelin:27618 {source="Gmelin"} xref: MetaCyc:CPD0-1267 xref: PMID:24101250 {source="Europe PMC"} xref: Reaxys:1909332 {source="Reaxys"} xref: Wikipedia:Isophthalic_acid is_a: CHEBI:26094 ! benzenedicarboxylic acid relationship: is_conjugate_acid_of CHEBI:30804 ! isophthalate(1-) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QQVIHTHCMHWDBS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "166.13084" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.02661" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1cccc(c1)C(O)=O" xsd:string [Term] id: CHEBI:30803 name: isophthalate(2-) namespace: chebi_ontology subset: 3_STAR synonym: "1,3-benzenedicarboxylate" RELATED [ChEBI] synonym: "benzene-1,3-dicarboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "isophthalate" RELATED [IUPAC] synonym: "isophthalate" RELATED [UniProt] xref: Beilstein:3906186 {source="Beilstein"} xref: Gmelin:328933 {source="Gmelin"} is_a: CHEBI:28965 ! dicarboxylic acid dianion relationship: is_conjugate_base_of CHEBI:30804 ! isophthalate(1-) property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H4O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QQVIHTHCMHWDBS-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "164.11496" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "164.01206" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)c1cccc(c1)C([O-])=O" xsd:string [Term] id: CHEBI:30804 name: isophthalate(1-) namespace: chebi_ontology def: "A dicarboxylic acid monoanion that is the conjugate base of isophthalic acid." [] subset: 3_STAR synonym: "3-carboxybenzoate" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen isophthalate" RELATED [IUPAC] xref: Gmelin:1947083 {source="Gmelin"} xref: MetaCyc:CPD0-1267 is_a: CHEBI:35695 ! dicarboxylic acid monoanion relationship: is_conjugate_acid_of CHEBI:30803 ! isophthalate(2-) relationship: is_conjugate_base_of CHEBI:30802 ! isophthalic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H5O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QQVIHTHCMHWDBS-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "165.12290" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.01933" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1cccc(c1)C([O-])=O" xsd:string [Term] id: CHEBI:30879 name: alcohol namespace: chebi_ontology alt_id: CHEBI:13804 alt_id: CHEBI:22288 alt_id: CHEBI:2553 def: "A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." [] subset: 3_STAR synonym: "Alcohol" EXACT [KEGG_COMPOUND] synonym: "alcohols" EXACT IUPAC_NAME [IUPAC] synonym: "an alcohol" RELATED [UniProt] xref: KEGG:C00069 is_a: CHEBI:33822 ! organic hydroxy compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HOR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "17.007" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[*]" xsd:string [Term] id: CHEBI:30911 name: glucitol namespace: chebi_ontology alt_id: CHEBI:15093 alt_id: CHEBI:26724 alt_id: CHEBI:26726 alt_id: CHEBI:33795 alt_id: CHEBI:33796 alt_id: CHEBI:9201 subset: 3_STAR synonym: "glucitol" EXACT IUPAC_NAME [IUPAC] synonym: "gulitol" RELATED [ChEBI] synonym: "rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol" RELATED [IUPAC] synonym: "Sorbitol" RELATED [KEGG_COMPOUND] xref: Beilstein:1721909 {source="Beilstein"} xref: Gmelin:83165 {source="Gmelin"} xref: Wikipedia:Sorbitol is_a: CHEBI:24583 ! hexitol relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H14O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "182.172" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "182.07904" xsd:string [Term] id: CHEBI:30938 name: 6-aminopenicillanate namespace: chebi_ontology alt_id: CHEBI:12207 alt_id: CHEBI:20704 subset: 3_STAR synonym: "(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:604420 {source="Gmelin"} xref: KEGG:C02954 is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_acid_of CHEBI:16705 ! 6-aminopenicillanic acid relationship: is_conjugate_base_of CHEBI:57869 ! 6-aminopenicillanic acid zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H11N2O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H12N2O3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,9H2,1-2H3,(H,12,13)/p-1/t3-,4+,6-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NGHVIOIJCVXTGV-ALEPSDHESA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "215.25062" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "215.04959" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(N)C(=O)N2[C@]1([H])SC(C)(C)[C@]2([H])C([O-])=O" xsd:string [Term] id: CHEBI:31011 name: valerate namespace: chebi_ontology alt_id: CHEBI:14751 alt_id: CHEBI:25890 def: "A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals." [] subset: 3_STAR synonym: "CH3-[CH2]3-COO(-)" RELATED [IUPAC] synonym: "n-propylacetate" RELATED [ChEBI] synonym: "pentanoate" EXACT IUPAC_NAME [IUPAC] synonym: "pentanoate" RELATED [UniProt] synonym: "pentanoic acid, ion(1-)" RELATED [ChemIDplus] xref: Beilstein:3903735 {source="Beilstein"} xref: CAS:10023-74-2 {source="ChemIDplus"} xref: Gmelin:325619 {source="Gmelin"} xref: PMID:17314444 {source="Europe PMC"} xref: PMID:18783570 {source="Europe PMC"} xref: Reaxys:3903735 {source="Reaxys"} is_a: CHEBI:58951 ! short-chain fatty acid anion is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion relationship: is_conjugate_base_of CHEBI:17418 ! valeric acid relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-2-3-4-5(6)7/h2-4H2,1H3,(H,6,7)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NQPDZGIKBAWPEJ-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "101.12376" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.06080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCC([O-])=O" xsd:string [Term] id: CHEBI:31014 name: tetracosanoate namespace: chebi_ontology def: "A straight-chain saturated fatty acid anion that is the conjugate base of tetracosanoic acid (lignoceric acid), formed by deprotonation of the carboxy group." [] subset: 3_STAR synonym: "CH3-[CH2]22-COO(-)" RELATED [IUPAC] synonym: "Lignocerat" RELATED [ChEBI] synonym: "lignocerate" RELATED [CBN] synonym: "n-tetracosanoate" RELATED [ChEBI] synonym: "tetracosanate" RELATED [ChEBI] synonym: "Tetracosanoat" RELATED [ChEBI] synonym: "tetracosanoate" EXACT [UniProt] synonym: "tetracosanoate" EXACT IUPAC_NAME [IUPAC] synonym: "tetracosoate" RELATED [ChEBI] synonym: "tetraeicosanoate" RELATED [ChEBI] xref: Gmelin:373325 {source="Gmelin"} xref: MetaCyc:TETRACOSANOATE is_a: CHEBI:58950 ! very long-chain fatty acid anion is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion is_a: CHEBI:78128 ! fatty acid anion 24:0 is_a: CHEBI:83955 ! 2-saturated fatty acid anion relationship: is_conjugate_base_of CHEBI:28866 ! tetracosanoic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H47O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QZZGJDVWLFXDLK-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "367.62880" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "367.35815" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCCCCCCCCCCCCC([O-])=O" xsd:string [Term] id: CHEBI:31286 name: bifonazole namespace: chebi_ontology def: "A racemate comprising equimolar amounts of R- and S-bifonazole. It is a broad spectrum antifungal drug used for the treatment of fungal skin and nail infections." [] subset: 3_STAR synonym: "(+-)-1-(p,alpha-Diphenylbenzyl)imidazole" RELATED [ChemIDplus] synonym: "(+-)-bifonazole" RELATED [ChEBI] synonym: "(+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole" RELATED [DrugBank] synonym: "(RS)-bifonazole" RELATED [ChEBI] synonym: "1-((4-Biphenylyl)phenylmethyl)-1H-imidazole" RELATED [DrugBank] synonym: "1-(alpha-(4-Biphenylyl)benzyl)imidazole" RELATED [ChemIDplus] synonym: "bifonazol" RELATED INN [DrugBank] synonym: "bifonazole" RELATED INN [WHO_MedNet] synonym: "bifonazole" RELATED INN [KEGG_DRUG] synonym: "bifonazolum" RELATED INN [DrugBank] synonym: "Mycospor" RELATED BRAND_NAME [KEGG_DRUG] synonym: "rac-1-[biphenyl-4-yl(phenyl)methyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] synonym: "rac-bifonazole" RELATED [ChEBI] synonym: "racemic bifonazole" RELATED [ChEBI] xref: CAS:60628-96-8 {source="ChemIDplus"} xref: CAS:60628-96-8 {source="KEGG DRUG"} xref: DrugBank:DB04794 xref: HMDB:HMDB0015583 xref: KEGG:D01775 xref: PMID:21746947 {source="Europe PMC"} xref: PMID:23066185 {source="Europe PMC"} xref: PMID:23283047 {source="Europe PMC"} xref: PMID:23467055 {source="Europe PMC"} xref: PMID:23586591 {source="Europe PMC"} xref: PMID:24215461 {source="Europe PMC"} xref: PMID:24849495 {source="Europe PMC"} xref: Reaxys:618427 {source="Reaxys"} xref: Wikipedia:Bifonazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87069 ! imidazole antifungal drug relationship: has_part CHEBI:78693 ! (R)-bifonazole relationship: has_part CHEBI:78694 ! (S)-bifonazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H18N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "310.39170" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "310.14700" xsd:string [Term] id: CHEBI:31577 name: ethylenediamine derivative namespace: chebi_ontology def: "Any organic amino compound that is a derivative of ethylenediamine." [] subset: 3_STAR synonym: "ethylenediamine derivatives" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: has_functional_parent CHEBI:30347 ! ethylenediamine [Term] id: CHEBI:31927 name: nystatin A3 namespace: chebi_ontology subset: 3_STAR synonym: "(1S,3R,4R,7R,9R,11R,15S,16S,17R,18S,19E,21E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-17-[(2,6-dideoxy-L-ribo-hexopyranosyl)oxy]-1,3,4,7,9,11,37-heptahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "nystatin A3" EXACT [KEGG_COMPOUND] xref: CAS:62997-67-5 {source="ChemIDplus"} xref: HMDB:HMDB0242303 xref: KEGG:C12156 xref: LIPID_MAPS_instance:LMPK06000005 {source="LIPID MAPS"} xref: PMID:15504830 {source="Europe PMC"} xref: PMID:27803316 {source="Europe PMC"} xref: PMID:3182406 {source="Europe PMC"} xref: PMID:468732 {source="Europe PMC"} is_a: CHEBI:59676 ! nystatins property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H85NO20" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H85NO20/c1-29-18-16-14-12-10-8-6-7-9-11-13-15-17-19-37(72-52-49(65)46(54)48(64)33(5)71-52)25-42-45(51(66)67)41(61)28-53(68,74-42)27-40(60)38(58)21-20-34(55)22-35(56)23-36(57)24-43(62)69-31(3)30(2)50(29)73-44-26-39(59)47(63)32(4)70-44/h6-7,9,11-19,29-42,44-50,52,55-61,63-65,68H,8,10,20-28,54H2,1-5H3,(H,66,67)/b7-6+,11-9+,14-12+,15-13+,18-16+,19-17+/t29-,30-,31-,32-,33+,34+,35+,36+,37-,38+,39+,40+,41-,42-,44?,45+,46-,47-,48+,49-,50+,52-,53+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IKYMLQOHQLVORI-PLAPNZKPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1056.250" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1055.56649" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\CC\\C=C\\C=C\\[C@H](C)[C@@H](OC3C[C@@H](O)[C@@H](O)[C@H](C)O3)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2" xsd:string [Term] id: CHEBI:32066 name: Prothionamide namespace: chebi_ontology alt_id: CHEBI:93717 subset: 2_STAR synonym: "2-Propylisonicotinylthioamide" RELATED [DrugCentral] synonym: "2-Propylthioisonicotinamide" RELATED [DrugCentral] synonym: "Prothionamide" EXACT [KEGG_COMPOUND] synonym: "prothionamide" EXACT [DrugCentral] synonym: "protionamid" RELATED [DrugCentral] xref: CAS:14222-60-7 {source="KEGG COMPOUND"} xref: CAS:14222-60-7 {source="DrugCentral"} xref: Drug_Central:2314 {source="DrugCentral"} xref: KEGG:D01195 xref: LINCS:LSM-4210 is_a: CHEBI:26421 ! pyridines property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12N2S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VRDIULHPQTYCLN-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.271" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.07212" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCC1=NC=CC(=C1)C(=S)N" xsd:string [Term] id: CHEBI:32158 name: streptomycin sulfate namespace: chebi_ontology subset: 2_STAR synonym: "Streptomycin sulfate" EXACT [KEGG_COMPOUND] xref: BPDB:2472 xref: CAS:3810-74-0 {source="KEGG COMPOUND"} xref: KEGG:D01350 is_a: CHEBI:38012 ! aminoglycoside sulfate salt relationship: has_functional_parent CHEBI:17076 ! streptomycin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "2C21H39N7O12.3H2O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C42H84N14O36S3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;;;/m00.../s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QTENRWWVYAAPBI-YCRXJPFRSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1457.389" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1456.43348" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS(=O)(O)=O.[C@@H]1([C@H](O[C@@H]2[C@H]([C@@H]([C@@H](NC(=N)N)[C@@H]([C@H]2O)O)O)NC(N)=N)O[C@H]([C@@]1(C=O)O)C)O[C@H]3[C@H]([C@@H]([C@@H](O)[C@@H](O3)CO)O)NC.OS(=O)(O)=O.OS(=O)(O)=O.[C@@H]1([C@H](O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)NC(=N)N)O)NC(N)=N)O[C@H]([C@@]1(C=O)O)C)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC" xsd:string [Term] id: CHEBI:32161 name: sulfadimethoxine namespace: chebi_ontology def: "A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position." [] subset: 3_STAR synonym: "2,4-dimethoxy-6-sulfanilamido-1,3-diazine" RELATED [ChemIDplus] synonym: "2,6-dimethoxy-4-(p-aminobenzenesulfonamido)pyrimidine" RELATED [ChemIDplus] synonym: "2,6-dimethoxy-4-sulfanilamidopyrimidine" RELATED [ChemIDplus] synonym: "4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide" RELATED [ChemIDplus] synonym: "4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide" EXACT IUPAC_NAME [IUPAC] synonym: "6-sulfanilamido-2,4-dimethoxypyrimidine" RELATED [ChemIDplus] synonym: "Abcid (TN)" RELATED [KEGG_DRUG] synonym: "Agribon (TN)" RELATED [KEGG_DRUG] synonym: "N(1)-(2,6-dimethoxy-4-pyrimidinyl)sulfanilamide" RELATED [ChemIDplus] synonym: "Sulfadimethoxine" EXACT [KEGG_DRUG] synonym: "sulfadimethoxinum" RELATED INN [ChemIDplus] synonym: "Sulfadimethoxydiazine" RELATED [ChemIDplus] synonym: "sulfadimetoxina" RELATED INN [ChemIDplus] synonym: "Sulphadimethoxine" RELATED [ChemIDplus] xref: Beilstein:306856 {source="Beilstein"} xref: CAS:122-11-2 {source="ChemIDplus"} xref: CAS:122-11-2 {source="KEGG DRUG"} xref: Drug_Central:2501 {source="DrugCentral"} xref: DrugBank:DB06150 xref: Gmelin:677830 {source="Gmelin"} xref: HMDB:HMDB0015621 xref: KEGG:D01142 xref: LINCS:LSM-5790 xref: PMID:11431418 {source="Europe PMC"} xref: PMID:12038137 {source="Europe PMC"} xref: PMID:13831481 {source="Europe PMC"} xref: PMID:13840927 {source="Europe PMC"} xref: PMID:14435331 {source="Europe PMC"} xref: PMID:14437387 {source="Europe PMC"} xref: PMID:16001847 {source="Europe PMC"} xref: PMID:16390193 {source="Europe PMC"} xref: PMID:18574183 {source="Europe PMC"} xref: PMID:19927815 {source="Europe PMC"} xref: Reaxys:306856 {source="Reaxys"} xref: VSDB:1833 xref: Wikipedia:Sulfadimethoxine is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39447 ! pyrimidines is_a: CHEBI:48975 ! substituted aniline is_a: CHEBI:87228 ! sulfonamide antibiotic relationship: has_functional_parent CHEBI:45373 ! sulfanilamide relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H14N4O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZZORFUFYDOWNEF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "310.33012" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "310.07358" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1" xsd:string [Term] id: CHEBI:32544 name: nicotinate namespace: chebi_ontology alt_id: CHEBI:14650 alt_id: CHEBI:22851 alt_id: CHEBI:25530 def: "A pyridinemonocarboxylate that is the conjugate base of nicotinic acid, arising from deprotonation of the carboxy group; major species at pH 7.3." [] subset: 3_STAR synonym: "3-pyridinecarboxylate" RELATED [ChEBI] synonym: "nicotinate" EXACT [UniProt] synonym: "pyridine-3-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3539722 {source="Beilstein"} xref: Gmelin:327384 {source="Gmelin"} xref: KEGG:C00253 xref: MetaCyc:NIACINE xref: PMID:17190852 {source="Europe PMC"} xref: PMID:21742010 {source="Europe PMC"} xref: PMID:21953179 {source="Europe PMC"} xref: Reaxys:3539722 {source="Reaxys"} is_a: CHEBI:176839 ! vitamin B3 is_a: CHEBI:38181 ! pyridinemonocarboxylate relationship: is_conjugate_base_of CHEBI:15940 ! nicotinic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H4NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PVNIIMVLHYAWGP-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "122.10150" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "122.02475" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)c1cccnc1" xsd:string [Term] id: CHEBI:32588 name: potassium chloride namespace: chebi_ontology def: "A metal chloride salt with a K(+) counterion." [] subset: 3_STAR synonym: "[KCl]" RELATED [MolBase] synonym: "Kaliumchlorid" RELATED [ChEBI] synonym: "Kaon-Cl 10" RELATED BRAND_NAME [KEGG_DRUG] synonym: "KCl" RELATED [IUPAC] synonym: "Klor-con" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Klotrix" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Monopotassium chloride" RELATED [DrugBank] synonym: "muriate of potash" RELATED [NIST_Chemistry_WebBook] synonym: "potassium chloride" EXACT IUPAC_NAME [IUPAC] synonym: "sylvite" RELATED [ChEBI] xref: CAS:7447-40-7 {source="NIST Chemistry WebBook"} xref: CAS:7447-40-7 {source="ChemIDplus"} xref: DrugBank:DB00761 xref: KEGG:D02060 xref: MetaCyc:KCL xref: MolBase:881 xref: Reaxys:3534978 {source="Reaxys"} xref: Wikipedia:Potassium_Chloride is_a: CHEBI:190303 ! inorganic potassium salt is_a: CHEBI:36093 ! inorganic chloride relationship: RO:0000087 CHEBI:33287 ! has role fertilizer property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "ClK" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH.K/h1H;/q;+1/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WCUXLLCKKVVCTQ-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.55100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.93256" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cl-].[K+]" xsd:string [Term] id: CHEBI:32600 name: tetracene namespace: chebi_ontology def: "An acene that consists of four ortho-fused benzene rings in a rectilinear arrangement." [] subset: 3_STAR synonym: "2,3-benzanthracene" RELATED [NIST_Chemistry_WebBook] synonym: "benz[b]anthracene" RELATED [NIST_Chemistry_WebBook] synonym: "naphthacene" RELATED [IUPAC] synonym: "tetracene" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:1909299 {source="Beilstein"} xref: CAS:92-24-0 {source="NIST Chemistry WebBook"} xref: CAS:92-24-0 {source="ChemIDplus"} xref: Gmelin:306993 {source="Gmelin"} xref: PMID:11493061 {source="Europe PMC"} xref: PMID:24655187 {source="Europe PMC"} xref: Reaxys:1909299 {source="Reaxys"} xref: Wikipedia:Tetracene is_a: CHEBI:35297 ! acene is_a: CHEBI:51270 ! tetracenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H12/c1-2-6-14-10-18-12-16-8-4-3-7-15(16)11-17(18)9-13(14)5-1/h1-12H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IFLREYGFSNHWGE-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "228.28788" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "228.09390" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2cc3cc4ccccc4cc3cc2c1" xsd:string [Term] id: CHEBI:32845 name: serinate namespace: chebi_ontology def: "An alpha-amino-acid anion that is the conjugate base of serine." [] subset: 3_STAR synonym: "2-amino-3-hydroxypropanoate" RELATED [IUPAC] synonym: "serinate" EXACT IUPAC_NAME [IUPAC] synonym: "serine anion" RELATED [JCBN] xref: Gmelin:324692 {source="Gmelin"} is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:17822 ! serine relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "104.08468" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "104.03532" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CO)C([O-])=O" xsd:string [Term] id: CHEBI:32846 name: serinium namespace: chebi_ontology def: "An alpha-amino-acid cation that is the conjugate acid of serine." [] subset: 3_STAR synonym: "1-carboxy-2-hydroxyethanaminium" RELATED [IUPAC] synonym: "serine cation" RELATED [JCBN] synonym: "serinium" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:1925675 {source="Gmelin"} is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:17822 ! serine relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H8NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/p+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "106.10056" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "106.04987" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CO)C(O)=O" xsd:string [Term] id: CHEBI:32862 name: L-prolinate namespace: chebi_ontology def: "An optically active form of prolinate having L-configuration." [] subset: 3_STAR synonym: "(2S)-pyrrolidine-2-carboxylate" RELATED [IUPAC] synonym: "L-prolinate" EXACT IUPAC_NAME [IUPAC] synonym: "L-proline anion" RELATED [JCBN] xref: Beilstein:4307988 {source="Beilstein"} xref: Gmelin:82610 {source="Gmelin"} xref: Reaxys:4307988 {source="Reaxys"} is_a: CHEBI:32871 ! prolinate is_a: CHEBI:59814 ! L-alpha-amino acid anion relationship: is_conjugate_base_of CHEBI:17203 ! L-proline relationship: is_enantiomer_of CHEBI:32867 ! D-prolinate relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p-1/t4-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "114.12250" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "114.05605" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[C@@H]1CCCN1" xsd:string [Term] id: CHEBI:32863 name: secondary amine namespace: chebi_ontology alt_id: CHEBI:26618 alt_id: CHEBI:9078 def: "A compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "R2NH" RELATED [IUPAC] synonym: "Secondary amine" EXACT [KEGG_COMPOUND] synonym: "secondary amines" EXACT IUPAC_NAME [IUPAC] synonym: "sekundaeres Amin" RELATED [ChEBI] xref: KEGG:C02324 is_a: CHEBI:32952 ! amine is_a: CHEBI:50995 ! secondary amino compound relationship: is_conjugate_base_of CHEBI:137419 ! secondary ammonium ion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HNR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "15.01460" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01090" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]N([*])[*]" xsd:string [Term] id: CHEBI:32864 name: L-prolinium namespace: chebi_ontology def: "An optically active form of prolinium having L-configuration." [] subset: 3_STAR synonym: "(2S)-2-carboxypyrrolidinium" RELATED [IUPAC] synonym: "L-proline cation" RELATED [JCBN] synonym: "L-prolinium" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:363493 {source="Gmelin"} is_a: CHEBI:32872 ! prolinium relationship: is_conjugate_acid_of CHEBI:17203 ! L-proline relationship: is_enantiomer_of CHEBI:32868 ! D-prolinium relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p+1/t4-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "116.13840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.07060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)[C@@H]1CCC[NH2+]1" xsd:string [Term] id: CHEBI:32867 name: D-prolinate namespace: chebi_ontology def: "An optically active form of prolinate having D-configuration." [] subset: 3_STAR synonym: "(2R)-pyrrolidine-2-carboxylate" RELATED [IUPAC] synonym: "D-prolinate" EXACT IUPAC_NAME [IUPAC] synonym: "D-proline anion" RELATED [JCBN] xref: Gmelin:533350 {source="Gmelin"} is_a: CHEBI:32871 ! prolinate relationship: is_conjugate_base_of CHEBI:16313 ! D-proline relationship: is_enantiomer_of CHEBI:32862 ! L-prolinate relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p-1/t4-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "114.12250" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "114.05605" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[C@H]1CCCN1" xsd:string [Term] id: CHEBI:32868 name: D-prolinium namespace: chebi_ontology def: "An optically active form of prolinium having D-configuration." [] subset: 3_STAR synonym: "(2R)-2-carboxypyrrolidinium" RELATED [IUPAC] synonym: "D-proline cation" RELATED [JCBN] synonym: "D-prolinium" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:363492 {source="Gmelin"} is_a: CHEBI:32872 ! prolinium relationship: is_conjugate_acid_of CHEBI:16313 ! D-proline relationship: is_enantiomer_of CHEBI:32864 ! L-prolinium relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p+1/t4-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "116.13840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.07060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)[C@H]1CCC[NH2+]1" xsd:string [Term] id: CHEBI:32871 name: prolinate namespace: chebi_ontology def: "An alpha-amino-acid anion that is the conjugate base of proline, arising from deprotonation of the carboxy group." [] subset: 3_STAR synonym: "pro(-)" RELATED [IUPAC] synonym: "prolinate" EXACT IUPAC_NAME [IUPAC] synonym: "proline anion" RELATED [JCBN] synonym: "pyrrolidine-2-carboxylate" RELATED [IUPAC] xref: Beilstein:5387795 {source="Beilstein"} xref: Gmelin:50151 {source="Gmelin"} xref: Reaxys:5387795 {source="Reaxys"} is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:26271 ! proline property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "114.12256" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "114.05605" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)C1CCCN1" xsd:string [Term] id: CHEBI:32872 name: prolinium namespace: chebi_ontology def: "An alpha-amino-acid cation that is the conjugate acid of proline, arising from protonation of the amino group." [] subset: 3_STAR synonym: "2-carboxypyrrolidinium" RELATED [IUPAC] synonym: "H2pro(+)" RELATED [IUPAC] synonym: "proline cation" RELATED [JCBN] synonym: "prolinium" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:26271 ! proline property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/p+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-UHFFFAOYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "116.13840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.07060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)C1CCC[NH2+]1" xsd:string [Term] id: CHEBI:32876 name: tertiary amine namespace: chebi_ontology alt_id: CHEBI:26879 alt_id: CHEBI:9458 def: "A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "R3N" RELATED [IUPAC] synonym: "tertiaeres Amin" RELATED [ChEBI] synonym: "Tertiary amine" EXACT [KEGG_COMPOUND] synonym: "tertiary amines" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C02196 is_a: CHEBI:32952 ! amine is_a: CHEBI:50996 ! tertiary amino compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "NR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "14.00670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N([*])[*]" xsd:string [Term] id: CHEBI:32877 name: primary amine namespace: chebi_ontology alt_id: CHEBI:26263 alt_id: CHEBI:26265 alt_id: CHEBI:8407 alt_id: CHEBI:8409 def: "A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group." [] subset: 3_STAR synonym: "primaeres Amin" RELATED [ChEBI] synonym: "Primary amine" EXACT [KEGG_COMPOUND] synonym: "primary amines" EXACT IUPAC_NAME [IUPAC] synonym: "Primary monoamine" RELATED [KEGG_COMPOUND] synonym: "R-NH2" RELATED [IUPAC] synonym: "RCH2NH2" RELATED [KEGG_COMPOUND] xref: KEGG:C00375 xref: KEGG:C00893 xref: KEGG:C02580 is_a: CHEBI:32952 ! amine is_a: CHEBI:50994 ! primary amino compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2NR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "16.02260" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01872" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[*]" xsd:string [Term] id: CHEBI:32952 name: amine namespace: chebi_ontology alt_id: CHEBI:13814 alt_id: CHEBI:22474 alt_id: CHEBI:2641 def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "Amin" RELATED [ChEBI] synonym: "Amine" EXACT [KEGG_COMPOUND] synonym: "amines" EXACT IUPAC_NAME [IUPAC] synonym: "Substituted amine" RELATED [KEGG_COMPOUND] xref: KEGG:C00706 is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:32955 name: epoxide namespace: chebi_ontology alt_id: CHEBI:13828 alt_id: CHEBI:23930 alt_id: CHEBI:4812 def: "Any cyclic ether in which the oxygen atom forms part of a 3-membered ring." [] subset: 3_STAR synonym: "Alkene oxide" RELATED [KEGG_COMPOUND] synonym: "an epoxide" RELATED [UniProt] synonym: "Epoxide" EXACT [KEGG_COMPOUND] synonym: "epoxides" EXACT IUPAC_NAME [IUPAC] synonym: "epoxides" RELATED [ChEBI] synonym: "Olefin oxide" RELATED [KEGG_COMPOUND] xref: KEGG:C00722 xref: PMID:10891060 {source="Europe PMC"} xref: Wikipedia:Epoxide is_a: CHEBI:37407 ! cyclic ether relationship: has_parent_hydride CHEBI:27561 ! oxirane property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2OR4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "40.02080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "39.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C1([*])OC1([*])[*]" xsd:string [Term] id: CHEBI:32964 name: ornithinate namespace: chebi_ontology alt_id: CHEBI:11448 alt_id: CHEBI:19370 subset: 3_STAR synonym: "2,5-diaminopentanoate" EXACT IUPAC_NAME [IUPAC] synonym: "ornithinate" EXACT IUPAC_NAME [IUPAC] synonym: "ornithine anion" RELATED [JCBN] xref: Gmelin:1242186 {source="Gmelin"} is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: has_functional_parent CHEBI:31011 ! valerate relationship: is_conjugate_base_of CHEBI:18257 ! ornithine property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H11N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "131.15312" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "131.08260" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCCC(N)C([O-])=O" xsd:string [Term] id: CHEBI:32988 name: amide namespace: chebi_ontology alt_id: CHEBI:22473 alt_id: CHEBI:2633 def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "Amide" EXACT [KEGG_COMPOUND] synonym: "amides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00241 is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:33173 name: benzimidazolide namespace: chebi_ontology subset: 3_STAR synonym: "benzimidazol-1-ide" EXACT IUPAC_NAME [IUPAC] synonym: "bim" RELATED [IUPAC] synonym: "bzim" RELATED [IUPAC] xref: Beilstein:3904522 {source="Beilstein"} xref: Gmelin:326519 {source="Gmelin"} is_a: CHEBI:50335 ! organic nitrogen anion relationship: is_conjugate_base_of CHEBI:41275 ! 1H-benzimidazole property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H5N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H5N2/c1-2-4-7-6(3-1)8-5-9-7/h1-5H/q-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KLTWGRFNJPLFDA-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "117.12808" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "117.04582" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2[n-]cnc2c1" xsd:string [Term] id: CHEBI:33229 name: vitamin (role) namespace: chebi_ontology alt_id: CHEBI:10004 alt_id: CHEBI:27305 def: "A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term \"vitamines\" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines." [] subset: 3_STAR synonym: "vitamin" RELATED [ChEBI] synonym: "vitamina" RELATED [ChEBI] synonym: "vitaminas" RELATED [ChEBI] synonym: "vitamine" RELATED [ChEBI] synonym: "vitamines" RELATED [ChEBI] synonym: "vitamins" RELATED [ChEBI] synonym: "vitaminum" RELATED [ChEBI] xref: Wikipedia:Vitamin is_a: CHEBI:27027 ! micronutrient is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:33231 name: antitubercular agent namespace: chebi_ontology def: "A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis." [] subset: 3_STAR synonym: "antitubercular" RELATED [ChEBI] synonym: "antitubercular agents" RELATED [ChEBI] synonym: "antitubercular drug" RELATED [ChEBI] synonym: "antitubercular drugs" RELATED [ChEBI] synonym: "tuberculostatic agent" RELATED [ChEBI] is_a: CHEBI:64912 ! antimycobacterial drug [Term] id: CHEBI:33232 name: application namespace: chebi_ontology def: "Intended use of the molecular entity or part thereof by humans." [] subset: 3_STAR is_a: BFO:0000023 ! role is_a: CHEBI:50906 ! role [Term] id: CHEBI:33233 name: fundamental particle namespace: chebi_ontology def: "A particle not known to have substructure." [] subset: 3_STAR synonym: "elementary particle" EXACT IUPAC_NAME [IUPAC] synonym: "elementary particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:33238 name: monoatomic entity namespace: chebi_ontology def: "A monoatomic entity is a molecular entity consisting of a single atom." [] subset: 3_STAR synonym: "atomic entity" RELATED [ChEBI] synonym: "monoatomic entities" RELATED [ChEBI] is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33240 name: coordination entity namespace: chebi_ontology def: "An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands)." [] subset: 3_STAR synonym: "coordination compounds" RELATED [ChEBI] synonym: "coordination entities" EXACT IUPAC_NAME [IUPAC] synonym: "coordination entity" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33241 name: oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_functional_parent CHEBI:24833 ! oxoacid [Term] id: CHEBI:33242 name: inorganic hydride namespace: chebi_ontology subset: 3_STAR synonym: "inorganic hydrides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:33245 name: organic fundamental parent namespace: chebi_ontology def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." [] subset: 3_STAR synonym: "organic fundamental parents" RELATED [ChEBI] synonym: "organic parent hydrides" RELATED [ChEBI] is_a: CHEBI:37175 ! organic hydride is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33246 name: inorganic group namespace: chebi_ontology def: "Any substituent group which does not contain carbon." [] subset: 3_STAR synonym: "inorganic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:33247 name: organic group namespace: chebi_ontology def: "Any substituent group or skeleton containing carbon." [] subset: 3_STAR synonym: "organic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group relationship: is_substituent_group_from CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33248 name: hydrocarbyl group namespace: chebi_ontology def: "A univalent group formed by removing a hydrogen atom from a hydrocarbon." [] subset: 3_STAR synonym: "groupe hydrocarbyle" RELATED [IUPAC] synonym: "grupo hidrocarbilo" RELATED [IUPAC] synonym: "grupos hidrocarbilo" RELATED [IUPAC] synonym: "hydrocarbyl group" EXACT [IUPAC] synonym: "hydrocarbyl groups" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33249 ! organyl group relationship: is_substituent_group_from CHEBI:24632 ! hydrocarbon [Term] id: CHEBI:33249 name: organyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." [] subset: 3_STAR synonym: "groupe organyle" RELATED [IUPAC] synonym: "grupo organilo" RELATED [IUPAC] synonym: "grupos organilo" RELATED [IUPAC] synonym: "organyl group" EXACT IUPAC_NAME [IUPAC] synonym: "organyl groups" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51447 ! organic univalent group [Term] id: CHEBI:33250 name: atom namespace: chebi_ontology alt_id: CHEBI:22671 alt_id: CHEBI:23907 def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." [] subset: 3_STAR synonym: "atom" EXACT IUPAC_NAME [IUPAC] synonym: "atome" RELATED [IUPAC] synonym: "atomo" RELATED [IUPAC] synonym: "atoms" RELATED [ChEBI] synonym: "atomus" RELATED [ChEBI] synonym: "element" RELATED [ChEBI] synonym: "elements" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: has_part CHEBI:10545 ! electron relationship: has_part CHEBI:33252 ! atomic nucleus [Term] id: CHEBI:33252 name: atomic nucleus namespace: chebi_ontology def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." [] subset: 3_STAR synonym: "Atomkern" RELATED [ChEBI] synonym: "Kern" RELATED [ChEBI] synonym: "noyau" RELATED [IUPAC] synonym: "noyau atomique" RELATED [ChEBI] synonym: "nuclei" RELATED [ChEBI] synonym: "nucleo" RELATED [IUPAC] synonym: "nucleo atomico" RELATED [ChEBI] synonym: "nucleus" EXACT IUPAC_NAME [IUPAC] synonym: "nucleus atomi" RELATED [ChEBI] is_a: CHEBI:36347 ! nuclear particle relationship: has_part CHEBI:33253 ! nucleon [Term] id: CHEBI:33253 name: nucleon namespace: chebi_ontology def: "Heavy nuclear particle: proton or neutron." [] subset: 3_STAR synonym: "nucleon" EXACT [IUPAC] synonym: "nucleon" EXACT IUPAC_NAME [IUPAC] synonym: "nucleons" RELATED [ChEBI] synonym: "Nukleon" RELATED [ChEBI] synonym: "Nukleonen" RELATED [ChEBI] is_a: CHEBI:36339 ! baryon is_a: CHEBI:36347 ! nuclear particle [Term] id: CHEBI:33256 name: primary amide namespace: chebi_ontology def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "primary amide" EXACT [IUPAC] synonym: "primary amides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:32988 ! amide [Term] id: CHEBI:33257 name: secondary amide namespace: chebi_ontology def: "A derivative of two oxoacids RkE(=O)l(OH)m (l =/= 0) in which two acyl groups are attached to the amino or substituted amino group." [] subset: 3_STAR synonym: "secondary amide" EXACT IUPAC_NAME [IUPAC] synonym: "secondary amides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:32988 ! amide [Term] id: CHEBI:33259 name: elemental molecular entity namespace: chebi_ontology def: "A molecular entity all atoms of which have the same atomic number." [] subset: 3_STAR synonym: "homoatomic entity" RELATED [ChEBI] synonym: "homoatomic molecular entities" RELATED [ChEBI] synonym: "homoatomic molecular entity" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:33261 name: organosulfur compound namespace: chebi_ontology alt_id: CHEBI:23010 alt_id: CHEBI:25714 def: "An organosulfur compound is a compound containing at least one carbon-sulfur bond." [] subset: 3_STAR synonym: "organosulfur compound" EXACT [ChEBI] synonym: "organosulfur compounds" RELATED [ChEBI] xref: Wikipedia:Organosulfur_compounds is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:33266 name: diatomic nitrogen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33267 ! elemental nitrogen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "28.013" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "28.00615" xsd:string [Term] id: CHEBI:33267 name: elemental nitrogen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33465 ! elemental pnictogen is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:33273 name: polyatomic anion namespace: chebi_ontology def: "An anion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36358 ! polyatomic ion [Term] id: CHEBI:33280 name: molecular messenger namespace: chebi_ontology subset: 3_STAR synonym: "chemical messenger" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33281 name: antimicrobial agent namespace: chebi_ontology alt_id: CHEBI:22582 def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." [] subset: 3_STAR synonym: "antibiotic" RELATED [ChEBI] synonym: "antibiotics" RELATED [ChEBI] synonym: "Antibiotika" RELATED [ChEBI] synonym: "Antibiotikum" RELATED [ChEBI] synonym: "antibiotique" RELATED [IUPAC] synonym: "antimicrobial" RELATED [ChEBI] synonym: "antimicrobial agents" RELATED [ChEBI] synonym: "antimicrobials" RELATED [ChEBI] synonym: "microbicide" RELATED [ChEBI] synonym: "microbicides" RELATED [ChEBI] xref: PMID:12964249 {source="Europe PMC"} xref: PMID:22117953 {source="Europe PMC"} xref: PMID:22439833 {source="Europe PMC"} xref: PMID:22849268 {source="Europe PMC"} xref: PMID:22849276 {source="Europe PMC"} xref: PMID:22958833 {source="Europe PMC"} is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33282 name: antibacterial agent namespace: chebi_ontology def: "A substance (or active part thereof) that kills or slows the growth of bacteria." [] subset: 3_STAR synonym: "antibacterial agents" RELATED [ChEBI] synonym: "antibacterials" RELATED [ChEBI] synonym: "bactericide" RELATED [ChEBI] synonym: "bactericides" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:33284 name: nutrient namespace: chebi_ontology def: "A nutrient is a food component that an organism uses to survive and grow." [] subset: 3_STAR synonym: "nutrients" RELATED [ChEBI] is_a: CHEBI:78295 ! food component [Term] id: CHEBI:33285 name: heteroorganic entity namespace: chebi_ontology def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." [] subset: 3_STAR synonym: "heteroorganic entities" RELATED [ChEBI] synonym: "organoelement compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33286 name: agrochemical namespace: chebi_ontology def: "An agrochemical is a substance that is used in agriculture or horticulture." [] subset: 3_STAR synonym: "agrichemical" RELATED [ChEBI] synonym: "agrichemicals" RELATED [ChEBI] synonym: "agricultural chemicals" RELATED [ChEBI] synonym: "agrochemicals" RELATED [ChEBI] xref: Wikipedia:Agrochemical is_a: CHEBI:33232 ! application [Term] id: CHEBI:33287 name: fertilizer namespace: chebi_ontology def: "A fertilizer is any substance that is added to soil or water to assist the growth of plants." [] subset: 3_STAR synonym: "fertiliser" RELATED [ChEBI] synonym: "fertilizers" RELATED [ChEBI] is_a: CHEBI:33286 ! agrochemical [Term] id: CHEBI:33292 name: fuel namespace: chebi_ontology def: "An energy-rich substance that can be transformed with release of usable energy." [] subset: 3_STAR is_a: CHEBI:33232 ! application [Term] id: CHEBI:33296 name: alkali metal molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of an alkali metal." [] subset: 3_STAR synonym: "alkali metal molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:22314 ! alkali metal atom [Term] id: CHEBI:33300 name: pnictogen namespace: chebi_ontology def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." [] subset: 3_STAR synonym: "group 15 elements" RELATED [ChEBI] synonym: "group V elements" RELATED [ChEBI] synonym: "nitrogenoideos" RELATED [ChEBI] synonym: "nitrogenoides" RELATED [ChEBI] synonym: "pnictogene" RELATED [ChEBI] synonym: "pnictogenes" RELATED [ChEBI] synonym: "pnictogens" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33302 name: pnictogen molecular entity namespace: chebi_ontology def: "A p-block molecular entity containing any pnictogen." [] subset: 3_STAR synonym: "pnictogen molecular entities" RELATED [ChEBI] synonym: "pnictogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33300 ! pnictogen [Term] id: CHEBI:33303 name: chalcogen namespace: chebi_ontology def: "Any p-block element belonging to the group 16 family of the periodic table." [] subset: 3_STAR synonym: "anfigeno" RELATED [ChEBI] synonym: "anfigenos" RELATED [ChEBI] synonym: "calcogeno" RELATED [ChEBI] synonym: "calcogenos" RELATED [ChEBI] synonym: "chalcogen" EXACT IUPAC_NAME [IUPAC] synonym: "chalcogene" RELATED [ChEBI] synonym: "chalcogenes" RELATED [ChEBI] synonym: "chalcogens" EXACT IUPAC_NAME [IUPAC] synonym: "Chalkogen" RELATED [ChEBI] synonym: "Chalkogene" RELATED [ChEBI] synonym: "group 16 elements" RELATED [ChEBI] synonym: "group VI elements" RELATED [ChEBI] xref: PMID:17084588 {source="Europe PMC"} is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33304 name: chalcogen molecular entity namespace: chebi_ontology def: "Any p-block molecular entity containing a chalcogen." [] subset: 3_STAR synonym: "chalcogen compounds" RELATED [ChEBI] synonym: "chalcogen molecular entities" RELATED [ChEBI] synonym: "chalcogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33303 ! chalcogen [Term] id: CHEBI:33306 name: carbon group element atom namespace: chebi_ontology subset: 3_STAR synonym: "carbon group element" RELATED [ChEBI] synonym: "carbon group elements" RELATED [ChEBI] synonym: "carbonoides" RELATED [ChEBI] synonym: "cristallogene" RELATED [ChEBI] synonym: "cristallogenes" RELATED [ChEBI] synonym: "group 14 elements" EXACT IUPAC_NAME [IUPAC] synonym: "group IV elements" RELATED [ChEBI] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33308 name: carboxylic ester namespace: chebi_ontology alt_id: CHEBI:13204 alt_id: CHEBI:23028 alt_id: CHEBI:3408 def: "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." [] subset: 3_STAR synonym: "a carboxylic ester" RELATED [UniProt] synonym: "carboxylic acid esters" RELATED [ChEBI] synonym: "Carboxylic ester" EXACT [KEGG_COMPOUND] synonym: "carboxylic esters" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C02391 xref: Wikipedia:Ester is_a: CHEBI:35701 ! ester is_a: CHEBI:36586 ! carbonyl compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)O[*]" xsd:string [Term] id: CHEBI:33318 name: main group element atom namespace: chebi_ontology def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." [] subset: 3_STAR synonym: "Hauptgruppenelement" RELATED [ChEBI] synonym: "Hauptgruppenelemente" RELATED [ChEBI] synonym: "main group element" RELATED [ChEBI] synonym: "main group elements" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33338 name: aryl group namespace: chebi_ontology def: "A group derived from an arene by removal of a hydrogen atom from a ring carbon atom." [] subset: 3_STAR synonym: "aryl groups" EXACT IUPAC_NAME [IUPAC] synonym: "Arylgruppe" RELATED [ChEBI] synonym: "groupe aryle" RELATED [IUPAC] synonym: "grupos arilo" RELATED [IUPAC] is_a: CHEBI:33248 ! hydrocarbyl group relationship: is_substituent_group_from CHEBI:33658 ! arene [Term] id: CHEBI:33340 name: zinc group element atom namespace: chebi_ontology subset: 3_STAR synonym: "group 12 elements" EXACT IUPAC_NAME [IUPAC] synonym: "zinc group element" RELATED [ChEBI] synonym: "zinc group elements" RELATED [ChEBI] is_a: CHEBI:33561 ! d-block element atom [Term] id: CHEBI:33352 name: manganese group element atom namespace: chebi_ontology subset: 3_STAR synonym: "group 7 elements" EXACT IUPAC_NAME [IUPAC] synonym: "manganese group element" RELATED [ChEBI] synonym: "manganese group elements" RELATED [ChEBI] is_a: CHEBI:33561 ! d-block element atom [Term] id: CHEBI:33366 name: copper group element atom namespace: chebi_ontology subset: 3_STAR synonym: "coinage metals" RELATED [ChEBI] synonym: "copper group element" RELATED [ChEBI] synonym: "copper group elements" RELATED [ChEBI] synonym: "group 11 elements" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33561 ! d-block element atom [Term] id: CHEBI:33402 name: sulfur oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "oxoacids of sulfur" RELATED [ChEBI] synonym: "sulfur oxoacids" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33484 ! chalcogen oxoacid [Term] id: CHEBI:33405 name: hydracid namespace: chebi_ontology def: "A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [] subset: 3_STAR synonym: "hydracid" EXACT IUPAC_NAME [IUPAC] synonym: "hydracids" RELATED [ChEBI] is_a: CHEBI:33608 ! hydrogen molecular entity relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid [Term] id: CHEBI:33408 name: pnictogen oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen oxoacids" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:33302 ! pnictogen molecular entity relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid [Term] id: CHEBI:33424 name: sulfur oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfur oxoacid derivative" EXACT [ChEBI] synonym: "sulfur oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33241 ! oxoacid derivative [Term] id: CHEBI:33429 name: monoatomic monoanion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic monoanions" RELATED [ChEBI] is_a: CHEBI:23905 ! monoatomic anion is_a: CHEBI:36830 ! monoanion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*-]" xsd:string [Term] id: CHEBI:33431 name: elemental chlorine namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:33434 ! elemental halogen [Term] id: CHEBI:33432 name: monoatomic chlorine namespace: chebi_ontology subset: 3_STAR synonym: "atomic chlorine" RELATED [ChEBI] is_a: CHEBI:33431 ! elemental chlorine is_a: CHEBI:33433 ! monoatomic halogen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "35.453" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96885" xsd:string [Term] id: CHEBI:33433 name: monoatomic halogen namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic halogens" RELATED [ChEBI] is_a: CHEBI:33238 ! monoatomic entity [Term] id: CHEBI:33434 name: elemental halogen namespace: chebi_ontology subset: 3_STAR synonym: "elemental halogen" EXACT [ChEBI] synonym: "elemental halogens" RELATED [ChEBI] is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33447 name: phospho sugar namespace: chebi_ontology alt_id: CHEBI:15132 alt_id: CHEBI:25406 alt_id: CHEBI:26086 alt_id: CHEBI:9320 def: "Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid." [] subset: 3_STAR synonym: "monosaccharide phosphates" RELATED [ChEBI] synonym: "phospho sugar" EXACT [ChEBI] synonym: "phospho sugars" RELATED [ChEBI] synonym: "phosphorylated sugar" RELATED [ChEBI] synonym: "phosphorylated sugars" RELATED [ChEBI] synonym: "phosphosugar" RELATED [ChEBI] synonym: "phosphosugars" RELATED [ChEBI] xref: KEGG:C00934 xref: PMID:18186488 {source="Europe PMC"} is_a: CHEBI:26816 ! carbohydrate phosphate is_a: CHEBI:63367 ! monosaccharide derivative [Term] id: CHEBI:33457 name: phosphorus oxoacid namespace: chebi_ontology def: "A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons." [] subset: 3_STAR synonym: "oxoacids of phosphorus" RELATED [ChEBI] synonym: "Oxosaeure des Phosphors" RELATED [ChEBI] synonym: "phosphorus oxoacid" EXACT [ChEBI] synonym: "phosphorus oxoacids" RELATED [ChEBI] is_a: CHEBI:33408 ! pnictogen oxoacid is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives [Term] id: CHEBI:33459 name: pnictogen oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen oxoanion" EXACT [ChEBI] synonym: "pnictogen oxoanions" RELATED [ChEBI] is_a: CHEBI:33302 ! pnictogen molecular entity is_a: CHEBI:35406 ! oxoanion [Term] id: CHEBI:33461 name: phosphorus oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "oxoanions of phosphorus" RELATED [ChEBI] synonym: "phosphorus oxoanion" EXACT [ChEBI] synonym: "phosphorus oxoanions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion is_a: CHEBI:26082 ! phosphorus molecular entity is_a: CHEBI:33459 ! pnictogen oxoanion [Term] id: CHEBI:33462 name: phosphonate(1-) namespace: chebi_ontology def: "A monovalent inorganic anion obtained by deprotonation of one of the two OH groups in phosphonic acid." [] subset: 3_STAR synonym: "[PHO2(OH)](-)" RELATED [IUPAC] synonym: "hydridohydroxidodioxidophosphate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen phosphonate" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogenphosphonate" RELATED [IUPAC] xref: PDBeChem:78T is_a: CHEBI:33461 ! phosphorus oxoanion is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:16215 ! phosphonate(2-) relationship: is_conjugate_base_of CHEBI:44976 ! phosphonic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O3P/c1-4(2)3/h4H,(H2,1,2,3)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ABLZXFCXXLZCGV-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "80.987" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.97470" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]P([O-])(O[H])=O" xsd:string [Term] id: CHEBI:33465 name: elemental pnictogen namespace: chebi_ontology subset: 3_STAR synonym: "elemental pnictogen" EXACT [ChEBI] synonym: "elemental pnictogens" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33259 ! elemental molecular entity is_a: CHEBI:33302 ! pnictogen molecular entity [Term] id: CHEBI:33482 name: sulfur oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "oxoanions of sulfur" RELATED [ChEBI] synonym: "sulfur oxoanion" EXACT [ChEBI] synonym: "sulfur oxoanions" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33485 ! chalcogen oxoanion [Term] id: CHEBI:33484 name: chalcogen oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoacid" EXACT [ChEBI] synonym: "chalcogen oxoacids" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid [Term] id: CHEBI:33485 name: chalcogen oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoanion" EXACT [ChEBI] synonym: "chalcogen oxoanions" RELATED [ChEBI] is_a: CHEBI:35406 ! oxoanion [Term] id: CHEBI:33497 name: transition element molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of a transition element." [] subset: 3_STAR synonym: "transition element molecular entities" RELATED [ChEBI] synonym: "transition metal molecular entity" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:27081 ! transition element atom [Term] id: CHEBI:33504 name: alkali metal cation namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal cations" RELATED [ChEBI] is_a: CHEBI:25213 ! metal cation [Term] id: CHEBI:33515 name: transition element cation namespace: chebi_ontology subset: 3_STAR synonym: "transition element cations" RELATED [ChEBI] synonym: "transition metal cation" RELATED [ChEBI] is_a: CHEBI:25213 ! metal cation [Term] id: CHEBI:33521 name: metal atom namespace: chebi_ontology alt_id: CHEBI:25217 alt_id: CHEBI:6788 def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." [] subset: 3_STAR synonym: "elemental metal" RELATED [ChEBI] synonym: "elemental metals" RELATED [ChEBI] synonym: "metal element" RELATED [ChEBI] synonym: "metal elements" RELATED [ChEBI] synonym: "metals" RELATED [ChEBI] xref: KEGG:C00050 xref: PMID:21784043 {source="Europe PMC"} xref: Wikipedia:Metal is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33535 name: sulfur hydride namespace: chebi_ontology subset: 3_STAR synonym: "hydrides of sulfur" RELATED [ChEBI] synonym: "sulfur hydride" EXACT [ChEBI] synonym: "sulfur hydrides" RELATED [ChEBI] synonym: "sulphur hydrides" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:36902 ! chalcogen hydride [Term] id: CHEBI:33543 name: sulfonate namespace: chebi_ontology def: "The sulfur oxoanion formed by deprotonation of sulfonic acid." [] subset: 3_STAR synonym: "[SHO3](-)" RELATED [IUPAC] synonym: "hydridotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "SHO3(-)" RELATED [IUPAC] synonym: "sulfonates" RELATED [ChEBI] xref: Gmelin:971569 {source="Gmelin"} is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_base_of CHEBI:29214 ! sulfonic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96519" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S([O-])(=O)=O" xsd:string [Term] id: CHEBI:33551 name: organosulfonic acid namespace: chebi_ontology def: "An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon." [] subset: 3_STAR synonym: "organosulfonic acids" RELATED [ChEBI] synonym: "sulfonic acids" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:33552 ! sulfonic acid derivative is_a: CHEBI:64709 ! organic acid relationship: has_part CHEBI:29922 ! sulfo group relationship: has_part CHEBI:33249 ! organyl group relationship: is_conjugate_acid_of CHEBI:33554 ! organosulfonate oxoanion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3SR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96464" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS([*])(=O)=O" xsd:string [Term] id: CHEBI:33552 name: sulfonic acid derivative namespace: chebi_ontology subset: 3_STAR synonym: "derivatives of sulfonic acid" RELATED [ChEBI] synonym: "sulfonic acid derivative" EXACT [ChEBI] synonym: "sulfonic acid derivatives" RELATED [ChEBI] is_a: CHEBI:33424 ! sulfur oxoacid derivative relationship: has_functional_parent CHEBI:29214 ! sulfonic acid [Term] id: CHEBI:33554 name: organosulfonate oxoanion namespace: chebi_ontology def: "An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid." [] subset: 3_STAR synonym: "organosulfonate" RELATED [ChEBI] synonym: "organosulfonate oxoanions" RELATED [ChEBI] synonym: "organosulfonates" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: has_functional_parent CHEBI:33543 ! sulfonate relationship: is_conjugate_base_of CHEBI:33551 ! organosulfonic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O3SR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "80.064" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.95681" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*S([O-])(=O)=O" xsd:string [Term] id: CHEBI:33555 name: arenesulfonic acid namespace: chebi_ontology def: "Organic derivatives of sulfonic acid in which the sulfo group is linked directly to carbon of an aryl group." [] subset: 3_STAR synonym: "arenesulfonic acids" RELATED [ChEBI] synonym: "arylsulfonic acid" RELATED [ChEBI] synonym: "arylsulfonic acids" RELATED [ChEBI] is_a: CHEBI:33551 ! organosulfonic acid relationship: has_part CHEBI:33338 ! aryl group relationship: is_conjugate_acid_of CHEBI:22713 ! arenesulfonate oxoanion [Term] id: CHEBI:33558 name: alpha-amino-acid anion namespace: chebi_ontology def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." [] subset: 3_STAR synonym: "alpha-amino acid anions" RELATED [ChEBI] synonym: "alpha-amino-acid anion" EXACT [ChEBI] synonym: "alpha-amino-acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33559 name: s-block element atom namespace: chebi_ontology subset: 3_STAR synonym: "s-block element" RELATED [ChEBI] synonym: "s-block elements" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33560 name: p-block element atom namespace: chebi_ontology def: "Any main group element atom belonging to the p-block of the periodic table." [] subset: 3_STAR synonym: "p-block element" RELATED [ChEBI] synonym: "p-block elements" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom [Term] id: CHEBI:33561 name: d-block element atom namespace: chebi_ontology subset: 3_STAR synonym: "d-block element" RELATED [ChEBI] synonym: "d-block elements" RELATED [ChEBI] is_a: CHEBI:27081 ! transition element atom [Term] id: CHEBI:33570 name: benzenediols namespace: chebi_ontology alt_id: CHEBI:22705 alt_id: CHEBI:22711 subset: 3_STAR is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:33572 name: resorcinols namespace: chebi_ontology def: "Any benzenediol in which the two hydroxy groups are meta to one another." [] subset: 3_STAR is_a: CHEBI:33570 ! benzenediols [Term] id: CHEBI:33575 name: carboxylic acid namespace: chebi_ontology alt_id: CHEBI:13428 alt_id: CHEBI:13627 alt_id: CHEBI:23027 def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." [] subset: 3_STAR synonym: "acide carboxylique" RELATED [IUPAC] synonym: "acides carboxyliques" RELATED [IUPAC] synonym: "acido carboxilico" RELATED [IUPAC] synonym: "acidos carboxilicos" RELATED [IUPAC] synonym: "Carbonsaeure" RELATED [ChEBI] synonym: "Carbonsaeuren" RELATED [ChEBI] synonym: "carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acids" EXACT IUPAC_NAME [IUPAC] synonym: "Karbonsaeure" RELATED [ChEBI] synonym: "RC(=O)OH" RELATED [IUPAC] xref: PMID:17147560 {source="Europe PMC"} xref: PMID:18433345 {source="Europe PMC"} xref: Wikipedia:Carboxylic_acid is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36586 ! carbonyl compound is_a: CHEBI:64709 ! organic acid relationship: has_part CHEBI:46883 ! carboxy group relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01740" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string [Term] id: CHEBI:33579 name: main group molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." [] subset: 3_STAR synonym: "main group compounds" RELATED [ChEBI] synonym: "main group molecular entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:33318 ! main group element atom [Term] id: CHEBI:33582 name: carbon group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "carbon group molecular entities" RELATED [ChEBI] synonym: "carbon group molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33306 ! carbon group element atom [Term] id: CHEBI:33595 name: cyclic compound namespace: chebi_ontology def: "Any molecule that consists of a series of atoms joined together to form a ring." [] subset: 3_STAR synonym: "cyclic compounds" RELATED [ChEBI] xref: Wikipedia:Cyclic_compound is_a: CHEBI:25367 ! molecule [Term] id: CHEBI:33597 name: homocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of the same element only." [] subset: 3_STAR synonym: "homocyclic compound" EXACT IUPAC_NAME [IUPAC] synonym: "homocyclic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "isocyclic compounds" RELATED [IUPAC] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33598 name: carbocyclic compound namespace: chebi_ontology def: "A homocyclic compound in which all of the ring members are carbon atoms." [] subset: 3_STAR synonym: "carbocycle" RELATED [ChEBI] synonym: "carbocyclic compound" EXACT IUPAC_NAME [IUPAC] synonym: "carbocyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33597 ! homocyclic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33599 name: spiro compound namespace: chebi_ontology def: "A compound having one atom as the only common member of two rings." [] subset: 3_STAR synonym: "spiro compound" EXACT IUPAC_NAME [IUPAC] synonym: "spiro compounds" EXACT IUPAC_NAME [IUPAC] synonym: "spiro-fused compounds" RELATED [IUPAC] synonym: "spirocycle" RELATED [ChEBI] synonym: "spirocycles" RELATED [ChEBI] synonym: "spirocyclic compound" RELATED [ChEBI] synonym: "spirocyclic compounds" RELATED [ChEBI] synonym: "spirofused compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound [Term] id: CHEBI:33608 name: hydrogen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "hydrogen compounds" RELATED [ChEBI] synonym: "hydrogen molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: has_part CHEBI:49637 ! hydrogen atom [Term] id: CHEBI:33635 name: polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33636 name: bicyclic compound namespace: chebi_ontology def: "A molecule that features two fused rings." [] subset: 3_STAR synonym: "bicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33637 name: ortho-fused compound namespace: chebi_ontology def: "A polycyclic compound in which two rings have two, and only two, atoms in common. Such compounds have n common faces and 2n common atoms." [] subset: 3_STAR synonym: "ortho-fused compounds" RELATED [ChEBI] synonym: "ortho-fused polycyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35293 ! fused compound [Term] id: CHEBI:33641 name: olefin namespace: chebi_ontology def: "Acyclic and cyclic hydrocarbons having one or more carbon-carbon double bonds, apart from the formal ones in aromatic compounds. The class olefins subsumes alkenes and cycloalkenes and the corresponding polyenes." [] subset: 3_STAR synonym: "olefin" EXACT IUPAC_NAME [IUPAC] synonym: "olefins" EXACT IUPAC_NAME [IUPAC] synonym: "olefins" RELATED [ChEBI] is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:33653 name: aliphatic compound namespace: chebi_ontology def: "Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds." [] subset: 3_STAR synonym: "aliphatic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33655 name: aromatic compound namespace: chebi_ontology def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." [] subset: 3_STAR synonym: "aromatic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "aromatic molecular entity" EXACT IUPAC_NAME [IUPAC] synonym: "aromatics" RELATED [ChEBI] synonym: "aromatische Verbindungen" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33658 name: arene namespace: chebi_ontology def: "Any monocyclic or polycyclic aromatic hydrocarbon." [] subset: 3_STAR synonym: "arene" EXACT IUPAC_NAME [IUPAC] synonym: "arenes" EXACT IUPAC_NAME [IUPAC] synonym: "aromatic hydrocarbons" RELATED [IUPAC] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33663 ! cyclic hydrocarbon [Term] id: CHEBI:33659 name: organic aromatic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic aromatic compounds" RELATED [ChEBI] is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33661 name: monocyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "monocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33662 name: annulene namespace: chebi_ontology def: "A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms." [] subset: 3_STAR synonym: "annulene" EXACT IUPAC_NAME [IUPAC] synonym: "annulenes" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33664 ! monocyclic hydrocarbon [Term] id: CHEBI:33663 name: cyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR synonym: "cyclic hydrocarbon" EXACT [ChEBI] synonym: "cyclic hydrocarbons" RELATED [ChEBI] is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:33598 ! carbocyclic compound [Term] id: CHEBI:33664 name: monocyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR synonym: "monocyclic hydrocarbon" EXACT [ChEBI] synonym: "monocyclic hydrocarbons" EXACT IUPAC_NAME [IUPAC] synonym: "monocyclic hydrocarbons" RELATED [ChEBI] is_a: CHEBI:33663 ! cyclic hydrocarbon [Term] id: CHEBI:33666 name: polycyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic hydrocarbon" EXACT IUPAC_NAME [IUPAC] synonym: "polycyclic hydrocarbons" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33663 ! cyclic hydrocarbon is_a: CHEBI:35294 ! carbopolycyclic compound [Term] id: CHEBI:33670 name: heteromonocyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heteromonocyclic compound" EXACT IUPAC_NAME [IUPAC] synonym: "heteromonocyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33661 ! monocyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33671 name: heteropolycyclic compound namespace: chebi_ontology def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." [] subset: 3_STAR synonym: "heteropolycyclic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "polyheterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33672 name: heterobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." [] subset: 3_STAR synonym: "heterobicyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33673 name: zinc group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc group molecular entities" RELATED [ChEBI] is_a: CHEBI:33676 ! d-block molecular entity relationship: has_part CHEBI:33340 ! zinc group element atom [Term] id: CHEBI:33674 name: s-block molecular entity namespace: chebi_ontology def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." [] subset: 3_STAR synonym: "s-block compounds" RELATED [ChEBI] synonym: "s-block molecular entities" RELATED [ChEBI] synonym: "s-block molecular entity" EXACT [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33559 ! s-block element atom [Term] id: CHEBI:33675 name: p-block molecular entity namespace: chebi_ontology def: "A main group molecular entity that contains one or more atoms of a p-block element." [] subset: 3_STAR synonym: "p-block compounds" RELATED [ChEBI] synonym: "p-block molecular entities" RELATED [ChEBI] synonym: "p-block molecular entitiy" RELATED [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: has_part CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33676 name: d-block molecular entity namespace: chebi_ontology def: "A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element." [] subset: 3_STAR synonym: "d-block compounds" RELATED [ChEBI] synonym: "d-block molecular entities" RELATED [ChEBI] synonym: "d-block molecular entity" EXACT [ChEBI] is_a: CHEBI:33497 ! transition element molecular entity relationship: has_part CHEBI:33561 ! d-block element atom [Term] id: CHEBI:33692 name: hydrides namespace: chebi_ontology def: "Hydrides are chemical compounds of hydrogen with other chemical elements." [] subset: 3_STAR is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33693 name: oxygen hydride namespace: chebi_ontology subset: 3_STAR synonym: "hydrides of oxygen" RELATED [ChEBI] synonym: "oxygen hydride" EXACT [ChEBI] synonym: "oxygen hydrides" RELATED [ChEBI] is_a: CHEBI:36902 ! chalcogen hydride [Term] id: CHEBI:33694 name: biomacromolecule namespace: chebi_ontology def: "A macromolecule formed by a living organism." [] subset: 3_STAR synonym: "biomacromolecules" RELATED [ChEBI] synonym: "biopolymer" EXACT IUPAC_NAME [IUPAC] synonym: "Biopolymere" RELATED [ChEBI] synonym: "biopolymers" RELATED [ChEBI] is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33695 name: information biomacromolecule namespace: chebi_ontology subset: 3_STAR synonym: "genetically encoded biomacromolecules" RELATED [ChEBI] synonym: "genetically encoded biopolymers" RELATED [ChEBI] synonym: "information biomacromolecules" RELATED [ChEBI] synonym: "information biopolymers" RELATED [ChEBI] synonym: "information macromolecule" RELATED [ChEBI] synonym: "information macromolecules" RELATED [ChEBI] is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:33696 name: nucleic acid namespace: chebi_ontology def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." [] subset: 3_STAR synonym: "acide nucleique" RELATED [ChEBI] synonym: "acides nucleiques" RELATED [ChEBI] synonym: "acido nucleico" RELATED [ChEBI] synonym: "acidos nucleicos" RELATED [ChEBI] synonym: "NA" RELATED [ChEBI] synonym: "nucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "Nukleinsaeure" RELATED [ChEBI] synonym: "Nukleinsaeuren" RELATED [ChEBI] is_a: CHEBI:15986 ! polynucleotide relationship: has_part CHEBI:33791 ! canonical nucleoside residue relationship: has_part CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:33697 name: ribonucleic acid namespace: chebi_ontology def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." [] subset: 3_STAR synonym: "pentosenucleic acids" RELATED [ChemIDplus] synonym: "ribonucleic acid" EXACT [IUPAC] synonym: "ribonucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "ribonucleic acids" RELATED [ChEBI] synonym: "Ribonukleinsaeure" RELATED [ChEBI] synonym: "ribose nucleic acid" RELATED [ChEBI] synonym: "RNA" RELATED [UniProt] synonym: "RNA" RELATED [IUPAC] synonym: "RNS" RELATED [ChEBI] synonym: "yeast nucleic acid" RELATED [ChEBI] xref: CAS:63231-63-0 {source="ChemIDplus"} is_a: CHEBI:33696 ! nucleic acid relationship: has_part CHEBI:33792 ! canonical ribonucleoside residue relationship: has_part CHEBI:50299 ! canonical ribonucleotide residue [Term] id: CHEBI:33700 name: proteinogenic amino-acid residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical amino-acid residue" RELATED [ChEBI] synonym: "canonical amino-acid residues" RELATED [ChEBI] synonym: "common amino acid residues" RELATED [ChEBI] synonym: "proteinogenic amino-acid residues" RELATED [ChEBI] synonym: "standard amino acid residues" RELATED [ChEBI] synonym: "standard amino-acid residues" RELATED [ChEBI] is_a: CHEBI:33710 ! alpha-amino-acid residue [Term] id: CHEBI:33702 name: polyatomic cation namespace: chebi_ontology def: "A cation consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic cations" RELATED [ChEBI] is_a: CHEBI:36358 ! polyatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:33703 name: amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "amino acid cation" RELATED [ChEBI] synonym: "amino-acid cation" EXACT [ChEBI] synonym: "amino-acid cations" RELATED [ChEBI] is_a: CHEBI:33702 ! polyatomic cation [Term] id: CHEBI:33704 name: alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:10208 alt_id: CHEBI:13779 alt_id: CHEBI:22442 alt_id: CHEBI:2642 def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." [] subset: 3_STAR synonym: "alpha-amino acid" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-amino acids" RELATED [JCBN] synonym: "alpha-amino acids" RELATED [ChEBI] synonym: "alpha-amino carboxylic acids" RELATED [IUPAC] synonym: "Amino acid" RELATED [KEGG_COMPOUND] synonym: "Amino acids" RELATED [KEGG_COMPOUND] xref: KEGG:C00045 xref: KEGG:C05167 is_a: CHEBI:33709 ! amino acid relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion relationship: is_tautomer_of CHEBI:78608 ! alpha-amino acid zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([*])C(O)=O" xsd:string [Term] id: CHEBI:33708 name: amino-acid residue namespace: chebi_ontology def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." [] subset: 3_STAR synonym: "amino acid residue" RELATED [ChEBI] synonym: "amino-acid residue" EXACT IUPAC_NAME [IUPAC] synonym: "amino-acid residues" RELATED [JCBN] is_a: CHEBI:33247 ! organic group relationship: is_substituent_group_from CHEBI:33709 ! amino acid [Term] id: CHEBI:33709 name: amino acid namespace: chebi_ontology alt_id: CHEBI:13815 alt_id: CHEBI:22477 def: "A carboxylic acid containing one or more amino groups." [] subset: 3_STAR synonym: "amino acids" RELATED [ChEBI] synonym: "Aminocarbonsaeure" RELATED [ChEBI] synonym: "Aminokarbonsaeure" RELATED [ChEBI] synonym: "Aminosaeure" RELATED [ChEBI] xref: Wikipedia:Amino_acid is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion [Term] id: CHEBI:3371 name: capreomycin namespace: chebi_ontology subset: 2_STAR synonym: "Capreomycin" EXACT [KEGG_COMPOUND] synonym: "capreomycins" RELATED [ChEBI] xref: CAS:11003-38-6 {source="KEGG COMPOUND"} xref: KEGG:C01790 xref: KEGG:D07607 is_a: CHEBI:25903 ! peptide antibiotic property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C25H43N14O7R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "522.519" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "522.24113" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC1NC(CC=N1)[C@@H]1NC(=O)\\C(NC(=O)[C@@H](CN[*])NC(=O)[C@@H](C[*])NC(=O)[C@@H](N)CNC1=O)=C\\NC(N)=O" xsd:string [Term] id: CHEBI:33710 name: alpha-amino-acid residue namespace: chebi_ontology subset: 3_STAR synonym: "alpha-amino-acid residues" RELATED [ChEBI] is_a: CHEBI:33708 ! amino-acid residue relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33719 name: alpha-amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "alpha-amino acid cations" RELATED [ChEBI] synonym: "alpha-amino-acid cation" EXACT [ChEBI] synonym: "alpha-amino-acid cations" RELATED [ChEBI] is_a: CHEBI:33703 ! amino-acid cation [Term] id: CHEBI:33743 name: manganese group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "manganese group molecular entities" RELATED [ChEBI] synonym: "manganese group molecular entity" EXACT [ChEBI] is_a: CHEBI:33676 ! d-block molecular entity relationship: has_part CHEBI:33352 ! manganese group element atom [Term] id: CHEBI:33745 name: copper group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "copper group molecular entities" RELATED [ChEBI] synonym: "copper group molecular entity" EXACT [ChEBI] is_a: CHEBI:33676 ! d-block molecular entity relationship: has_part CHEBI:33366 ! copper group element atom [Term] id: CHEBI:33791 name: canonical nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleoside residues" RELATED [ChEBI] synonym: "common nucleoside residues" RELATED [CBN] synonym: "nucleoside residue" RELATED [CBN] synonym: "standard nucleoside residues" RELATED [ChEBI] is_a: CHEBI:50320 ! nucleoside residue [Term] id: CHEBI:33792 name: canonical ribonucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleoside residues" RELATED [ChEBI] synonym: "common ribonucleoside residue" RELATED [CBN] synonym: "common ribonucleoside residues" RELATED [CBN] synonym: "N" RELATED [CBN] synonym: "Nuc" RELATED [CBN] synonym: "standard ribonucleoside residues" RELATED [ChEBI] is_a: CHEBI:33791 ! canonical nucleoside residue [Term] id: CHEBI:33822 name: organic hydroxy compound namespace: chebi_ontology alt_id: CHEBI:64710 def: "An organic compound having at least one hydroxy group attached to a carbon atom." [] subset: 3_STAR synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC] synonym: "organic alcohol" RELATED [ChEBI] synonym: "organic hydroxy compounds" RELATED [ChEBI] is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33832 name: organic cyclic compound namespace: chebi_ontology def: "Any organic molecule that consists of atoms connected in the form of a ring." [] subset: 3_STAR synonym: "organic cyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:33833 name: heteroarene namespace: chebi_ontology def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." [] subset: 3_STAR synonym: "hetarenes" RELATED [IUPAC] synonym: "heteroarenes" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:33836 name: benzenoid aromatic compound namespace: chebi_ontology subset: 3_STAR synonym: "benzenoid aromatic compounds" RELATED [ChEBI] synonym: "benzenoid compound" RELATED [ChEBI] is_a: CHEBI:33598 ! carbocyclic compound is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:33838 name: nucleoside namespace: chebi_ontology alt_id: CHEBI:13661 alt_id: CHEBI:25611 alt_id: CHEBI:7647 def: "An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents." [] subset: 3_STAR synonym: "a nucleoside" RELATED [UniProt] synonym: "Nucleoside" EXACT [KEGG_COMPOUND] synonym: "nucleosides" EXACT IUPAC_NAME [IUPAC] synonym: "nucleosides" RELATED [ChEBI] xref: KEGG:C00801 xref: Wikipedia:Nucleoside is_a: CHEBI:21731 ! N-glycosyl compound is_a: CHEBI:26912 ! oxolanes is_a: CHEBI:61120 ! nucleobase-containing molecular entity property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8O3R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "116.115" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.04734" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H]1([C@H]([C@@H](*)[C@@H](O1)*)O)CO" xsd:string [Term] id: CHEBI:33839 name: macromolecule namespace: chebi_ontology def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [] subset: 3_STAR synonym: "macromolecule" EXACT IUPAC_NAME [IUPAC] synonym: "macromolecules" RELATED [ChEBI] synonym: "polymer" RELATED [ChEBI] synonym: "polymer molecule" RELATED [IUPAC] synonym: "polymers" RELATED [ChEBI] xref: Wikipedia:Macromolecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:33842 name: aromatic annulene namespace: chebi_ontology subset: 3_STAR synonym: "aromatic annulenes" RELATED [ChEBI] is_a: CHEBI:33662 ! annulene is_a: CHEBI:33847 ! monocyclic arene [Term] id: CHEBI:33847 name: monocyclic arene namespace: chebi_ontology def: "A monocyclic aromatic hydrocarbon." [] subset: 3_STAR synonym: "monocyclic arenes" RELATED [ChEBI] is_a: CHEBI:33658 ! arene [Term] id: CHEBI:33848 name: polycyclic arene namespace: chebi_ontology def: "A polycyclic aromatic hydrocarbon." [] subset: 3_STAR synonym: "PAH" RELATED [ChEBI] synonym: "PAHs" RELATED [ChEBI] synonym: "polycyclic arenes" RELATED [ChEBI] synonym: "polycyclic aromatic hydrocarbons" RELATED [ChEBI] xref: PMID:15198916 {source="Europe PMC"} xref: PMID:25679824 {source="Europe PMC"} xref: Wikipedia:Polycyclic_aromatic_hydrocarbon is_a: CHEBI:33658 ! arene is_a: CHEBI:33666 ! polycyclic hydrocarbon relationship: RO:0000087 CHEBI:138015 ! has role endocrine disruptor relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent [Term] id: CHEBI:33853 name: phenols namespace: chebi_ontology alt_id: CHEBI:13664 alt_id: CHEBI:13825 alt_id: CHEBI:25969 alt_id: CHEBI:2857 def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." [] subset: 3_STAR synonym: "a phenol" RELATED [UniProt] synonym: "arenols" RELATED [IUPAC] synonym: "Aryl alcohol" RELATED [KEGG_COMPOUND] synonym: "phenols" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C15584 xref: MetaCyc:Phenols xref: Wikipedia:Phenols is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6HOR5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "89.072" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=C(C(=C(C(=C1*)*)*)*)*)O" xsd:string [Term] id: CHEBI:33856 name: aromatic amino acid namespace: chebi_ontology alt_id: CHEBI:13820 alt_id: CHEBI:22623 alt_id: CHEBI:2835 def: "An amino acid whose structure includes an aromatic ring." [] subset: 3_STAR synonym: "Aromatic amino acid" EXACT [KEGG_COMPOUND] synonym: "aromatic amino acids" RELATED [ChEBI] xref: KEGG:C01021 xref: Wikipedia:Aromatic_amino_acid is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33709 ! amino acid relationship: is_conjugate_acid_of CHEBI:63473 ! aromatic amino-acid anion relationship: is_tautomer_of CHEBI:76042 ! aromatic amino-acid zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "88.085" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string [Term] id: CHEBI:33859 name: aromatic carboxylic acid namespace: chebi_ontology alt_id: CHEBI:13817 alt_id: CHEBI:13821 alt_id: CHEBI:2830 def: "Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring." [] subset: 3_STAR synonym: "aromatic carboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:33659 ! organic aromatic compound relationship: is_conjugate_acid_of CHEBI:91007 ! aromatic carboxylate [Term] id: CHEBI:33860 name: aromatic amine namespace: chebi_ontology alt_id: CHEBI:13827 alt_id: CHEBI:22622 alt_id: CHEBI:22646 alt_id: CHEBI:2834 alt_id: CHEBI:2863 def: "An amino compound in which the amino group is linked directly to an aromatic system." [] subset: 3_STAR synonym: "aromatic amines" RELATED [ChEBI] synonym: "aryl amine" RELATED [ChEBI] synonym: "aryl amines" RELATED [ChEBI] synonym: "arylamine" RELATED [ChEBI] synonym: "arylamines" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:33861 name: transition element coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "transition element coordination entities" RELATED [ChEBI] synonym: "transition metal coordination compounds" RELATED [ChEBI] synonym: "transition metal coordination entities" RELATED [ChEBI] is_a: CHEBI:33240 ! coordination entity is_a: CHEBI:33497 ! transition element molecular entity [Term] id: CHEBI:33893 name: reagent namespace: chebi_ontology def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." [] subset: 3_STAR synonym: "reactif" RELATED [IUPAC] synonym: "reactivo" RELATED [IUPAC] synonym: "reagent" EXACT IUPAC_NAME [IUPAC] synonym: "reagents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:33917 name: aldohexose namespace: chebi_ontology alt_id: CHEBI:2558 def: "A hexose with a (potential) aldehyde group at one end." [] subset: 3_STAR synonym: "aldohexose" EXACT [ChEBI] synonym: "aldohexoses" RELATED [ChEBI] is_a: CHEBI:15693 ! aldose is_a: CHEBI:18133 ! hexose [Term] id: CHEBI:3392 name: carbendazim namespace: chebi_ontology def: "A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables." [] subset: 3_STAR synonym: "1H-benzimidazol-2-ylcarbamic acid methyl ester" RELATED [ChEBI] synonym: "2-(Methoxy-carbonylamino)-benzimidazol" RELATED [ChemIDplus] synonym: "2-(methoxycarbonylamino)-benzimidazole" RELATED [ChemIDplus] synonym: "2-(methoxycarbonylamino)benzimidazole" RELATED [ChEBI] synonym: "2-benzimidazolecarbamic acid methyl ester" RELATED [ChEBI] synonym: "BMC" RELATED [ChEBI] synonym: "Carbendazim" EXACT [KEGG_COMPOUND] synonym: "carbendazim" EXACT [UniProt] synonym: "carbendazime" RELATED [ChemIDplus] synonym: "MBC" RELATED [ChEBI] synonym: "Mecarzole" RELATED [KEGG_COMPOUND] synonym: "methyl 1H-benzimidazol-2-ylcarbamate" EXACT IUPAC_NAME [IUPAC] synonym: "methyl 2-benzimidazolecarbamate" RELATED [ChemIDplus] synonym: "methyl benzimidazol-2-ylcarbamate" RELATED [ChemIDplus] xref: CAS:10605-21-7 {source="KEGG COMPOUND"} xref: CAS:10605-21-7 {source="ChemIDplus"} xref: HMDB:HMDB0031769 xref: KEGG:C10897 xref: Patent:US3010968 xref: Pesticides:carbendazim {source="Alan Wood's Pesticides"} xref: PMID:20833408 {source="Europe PMC"} xref: PMID:21315898 {source="Europe PMC"} xref: PMID:22077925 {source="Europe PMC"} xref: PMID:22903170 {source="Europe PMC"} xref: PPDB:116 xref: Reaxys:649044 {source="Reaxys"} xref: Wikipedia:Carbendazim is_a: CHEBI:87036 ! benzimidazole fungicide is_a: CHEBI:87064 ! benzimidazolylcarbamate fungicide relationship: has_functional_parent CHEBI:27822 ! 2-aminobenzimidazole relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug relationship: RO:0000087 CHEBI:61951 ! has role microtubule-destabilising agent relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H9N3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TWFZGCMQGLPBSX-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "191.18670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "191.06948" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)Nc1nc2ccccc2[nH]1" xsd:string [Term] id: CHEBI:3393 name: carbenicillin namespace: chebi_ontology def: "A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6beta-(2-carboxy-2-phenylacetamido)-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-carboxybenzylpencillin" RELATED [ChemIDplus] synonym: "alpha-phenyl(carboxymethylpenicillin)" RELATED [ChemIDplus] synonym: "carbenicilina" RELATED INN [DrugBank] synonym: "carbenicillin" RELATED INN [KEGG_DRUG] synonym: "carbenicilline" RELATED INN [DrugBank] synonym: "carbenicillinum" RELATED INN [DrugBank] synonym: "carboxybenzylpenicillin" RELATED [DrugBank] synonym: "CBPC" RELATED [ChEBI] synonym: "N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid" RELATED [ChemIDplus] xref: Beilstein:1230663 {source="Beilstein"} xref: CAS:4697-36-3 {source="KEGG COMPOUND"} xref: CAS:4697-36-3 {source="ChemIDplus"} xref: Drug_Central:492 {source="DrugCentral"} xref: DrugBank:DB00578 xref: HMDB:HMDB0014717 xref: KEGG:C06869 xref: KEGG:D07614 xref: Patent:US3142673 xref: PMID:12569987 {source="Europe PMC"} xref: PMID:22648337 {source="Europe PMC"} xref: PMID:6176550 {source="Europe PMC"} xref: Reaxys:1230663 {source="Reaxys"} xref: Wikipedia:Carbenicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51897 ! carbenicillin(2-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H18N2O6S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25)/t9?,10-,11+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FPPNZSSZRUTDAP-UWFZAAFLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "378.40070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "378.08856" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C(C(O)=O)c1ccccc1)C(O)=O" xsd:string [Term] id: CHEBI:33937 name: macronutrient namespace: chebi_ontology def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." [] subset: 3_STAR synonym: "macronutrients" RELATED [ChEBI] is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:33958 name: halide salt namespace: chebi_ontology subset: 3_STAR synonym: "halide salts" RELATED [ChEBI] synonym: "halides" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:37578 ! halide relationship: has_part CHEBI:16042 ! halide anion [Term] id: CHEBI:34043 name: 1,2-phenylenediamine namespace: chebi_ontology def: "A phenylenediamine in which the two amino groups are ortho to each other." [] subset: 3_STAR synonym: "1,2-Diaminobenzene" RELATED [KEGG_COMPOUND] synonym: "2-Aminoaniline" RELATED [ChemIDplus] synonym: "2-Phenylene diamine" RELATED [KEGG_COMPOUND] synonym: "benzene-1,2-diamine" EXACT IUPAC_NAME [IUPAC] synonym: "o-Phenylenediamine" RELATED [KEGG_COMPOUND] synonym: "OPDA" RELATED [ChemIDplus] synonym: "phenylene-1,2-dimaine" RELATED [ChEBI] xref: Beilstein:606074 {source="Beilstein"} xref: CAS:95-54-5 {source="KEGG COMPOUND"} xref: CAS:95-54-5 {source="ChemIDplus"} xref: CAS:95-54-5 {source="NIST Chemistry WebBook"} xref: KEGG:C14402 xref: PMID:23099167 {source="Europe PMC"} xref: PMID:23172354 {source="Europe PMC"} xref: PMID:23220522 {source="Europe PMC"} xref: PMID:23232561 {source="Europe PMC"} xref: PMID:23245188 {source="Europe PMC"} xref: PMID:23317160 {source="Europe PMC"} xref: PMID:23323634 {source="Europe PMC"} xref: PMID:23364618 {source="Europe PMC"} xref: PMID:23452313 {source="Europe PMC"} xref: PMID:2420897 {source="Europe PMC"} xref: PMID:9025914 {source="Europe PMC"} xref: Reaxys:606074 {source="Reaxys"} xref: Wikipedia:O-Phenylenediamine is_a: CHEBI:51402 ! phenylenediamine relationship: has_parent_hydride CHEBI:16716 ! benzene relationship: RO:0000087 CHEBI:17499 ! has role hydrogen donor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H8N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8N2/c7-5-3-1-2-4-6(5)8/h1-4H,7-8H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GEYOCULIXLDCMW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "108.14120" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "108.06875" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ccccc1N" xsd:string [Term] id: CHEBI:3405 name: carboxin namespace: chebi_ontology def: "An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment." [] subset: 3_STAR synonym: "2,3-Dihydro-5-carboxanilido-6-methyl-1,4-oxathiin" RELATED [ChemIDplus] synonym: "2,3-Dihydro-6-methyl-1,4-oxathiin-5-carboxanilide" RELATED [NIST_Chemistry_WebBook] synonym: "2,3-Dihydro-6-methyl-5-phenylcarbamoyl-1,4-oxathiin" RELATED [ChemIDplus] synonym: "2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "5,6-Dihydro-2-methyl-1,4-oxathiin-3-carboxanilide" RELATED [ChemIDplus] synonym: "5,6-Dihydro-2-methyl-3-carboxanilido-1,4-oxathiin" RELATED [ChemIDplus] synonym: "5,6-Dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide" RELATED [ChemIDplus] synonym: "5-Carboxanilido-2,3-dihydro-6-methyl-1,4-oxathiin" RELATED [ChemIDplus] synonym: "Carbathiin" RELATED [ChemIDplus] synonym: "Carboxine" RELATED [ChemIDplus] synonym: "oxatin" RELATED [MetaCyc] xref: Beilstein:983249 {source="ChemIDplus"} xref: CAS:5234-68-4 {source="NIST Chemistry WebBook"} xref: CAS:5234-68-4 {source="ChemIDplus"} xref: CAS:5234-68-4 {source="KEGG COMPOUND"} xref: KEGG:C11255 xref: LINCS:LSM-25660 xref: MetaCyc:CPD0-1366 xref: Patent:EP0042182 xref: PDBeChem:CBE xref: Pesticides:carboxin {source="Alan Wood's Pesticides"} xref: PMID:21228470 {source="Europe PMC"} xref: PMID:23047320 {source="Europe PMC"} xref: PMID:23261124 {source="Europe PMC"} xref: PMID:24119086 {source="Europe PMC"} xref: PMID:24785712 {source="Europe PMC"} xref: PMID:30724184 {source="Europe PMC"} xref: PMID:34065659 {source="Europe PMC"} xref: PMID:35182799 {source="Europe PMC"} xref: PMID:5386172 {source="Europe PMC"} xref: PMID:5487095 {source="Europe PMC"} xref: PMID:974232 {source="Europe PMC"} xref: PPDB:122 xref: Reaxys:983249 {source="Reaxys"} is_a: CHEBI:13248 ! anilide is_a: CHEBI:140325 ! secondary carboxamide is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38106 ! organosulfur heterocyclic compound is_a: CHEBI:51751 ! enamide is_a: CHEBI:87015 ! anilide fungicide relationship: RO:0000087 CHEBI:83072 ! has role EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H13NO2S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H13NO2S/c1-9-11(16-8-7-15-9)12(14)13-10-5-3-2-4-6-10/h2-6H,7-8H2,1H3,(H,13,14)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GYSSRZJIHXQEHQ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "235.300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "235.06670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1=C(SCCO1)C(=O)NC1=CC=CC=C1" xsd:string [Term] id: CHEBI:34608 name: captan namespace: chebi_ontology def: "A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops." [] subset: 3_STAR synonym: "1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide" RELATED [ChemIDplus] synonym: "2-[(trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione" EXACT IUPAC_NAME [IUPAC] synonym: "3a,4,7,7a-Tetrahydro-2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione" RELATED [ChemIDplus] synonym: "3a,4,7,7a-tetrahydro-N-(trichloromethanesulphenyl)phthalimide" RELATED [ChemIDplus] synonym: "Amercide" RELATED BRAND_NAME [ChemIDplus] synonym: "Bangton" RELATED BRAND_NAME [ChemIDplus] synonym: "Captab" RELATED BRAND_NAME [ChemIDplus] synonym: "Captadin" RELATED BRAND_NAME [ChemIDplus] synonym: "Captaf" RELATED BRAND_NAME [ChemIDplus] synonym: "captane" RELATED [ChemIDplus] synonym: "Captanex" RELATED BRAND_NAME [ChemIDplus] synonym: "Captex" RELATED BRAND_NAME [ChemIDplus] synonym: "ENT 26,538" RELATED [ChemIDplus] synonym: "Hexacap" RELATED BRAND_NAME [ChemIDplus] synonym: "Kaptan" RELATED BRAND_NAME [ChemIDplus] synonym: "Malipur" RELATED BRAND_NAME [ChemIDplus] synonym: "Merpan" RELATED BRAND_NAME [ChemIDplus] synonym: "N-(trichloromethylmercapto)-Delta(4)-tetrahydrophthalimide" RELATED [ChemIDplus] synonym: "N-[(trichloromethyl)thio]tetrahydrophthalimide" RELATED [ChemIDplus] synonym: "N-trichloromethylmercapto-4-cyclohexene-1,2-dicarboximide" RELATED [ChemIDplus] synonym: "N-trichloromethylthio-3a,4,7,7a-tetrahydrophthalimide" RELATED [ChemIDplus] synonym: "N-trichloromethylthiocyclohex-4-ene-1,2-dicarboximide" RELATED [ChemIDplus] synonym: "Neracid" RELATED BRAND_NAME [ChemIDplus] synonym: "Orthocide" RELATED BRAND_NAME [ChemIDplus] synonym: "Osocide" RELATED BRAND_NAME [ChemIDplus] synonym: "SR 406" RELATED [ChemIDplus] synonym: "SR406" RELATED [ChemIDplus] synonym: "Vanicide" RELATED BRAND_NAME [ChemIDplus] synonym: "Venturin" RELATED BRAND_NAME [NIST_Chemistry_WebBook] synonym: "Vondcaptan" RELATED BRAND_NAME [NIST_Chemistry_WebBook] synonym: "Zenecal" RELATED BRAND_NAME [NIST_Chemistry_WebBook] xref: CAS:133-06-2 {source="KEGG COMPOUND"} xref: CAS:133-06-2 {source="ChemIDplus"} xref: CAS:133-06-2 {source="NIST Chemistry WebBook"} xref: KEGG:C14438 xref: Patent:US2553771 xref: Patent:US2653155 xref: Patent:US2713058 xref: Pesticides:captan {source="Alan Wood's Pesticides"} xref: PMID:20433167 {source="Europe PMC"} xref: PMID:20569196 {source="Europe PMC"} xref: PMID:21121628 {source="Europe PMC"} xref: PMID:21381057 {source="Europe PMC"} xref: PMID:21381058 {source="Europe PMC"} xref: PMID:23692481 {source="Europe PMC"} xref: PMID:23742211 {source="Europe PMC"} xref: PMID:6578186 {source="Europe PMC"} xref: PMID:9530801 {source="Europe PMC"} xref: PPDB:114 xref: Wikipedia:Captan is_a: CHEBI:24897 ! isoindoles is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:87198 ! phthalimide fungicide relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H8Cl3NO2S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H8Cl3NO2S/c10-9(11,12)16-13-7(14)5-3-1-2-4-6(5)8(13)15/h1-2,5-6H,3-4H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LDVVMCZRFWMZSG-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "300.58900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "298.93413" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "ClC(Cl)(Cl)SN1C(=O)C2CC=CCC2C1=O" xsd:string [Term] id: CHEBI:34653 name: Congo Red namespace: chebi_ontology def: "An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0." [] subset: 3_STAR synonym: "Congo red" EXACT [KEGG_COMPOUND] synonym: "Direct red 28" RELATED [KEGG_COMPOUND] synonym: "disodium 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(4-aminonaphthalene-1-sulphonate)" RELATED [ChemIDplus] synonym: "disodium 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate)" EXACT IUPAC_NAME [IUPAC] synonym: "Kongorot" RELATED [ChemIDplus] synonym: "Sodium diphenyldiazo-bis-alpha-naphthylaminesulfonate" RELATED [KEGG_COMPOUND] xref: Beilstein:3894858 {source="Beilstein"} xref: Beilstein:741468 {source="Beilstein"} xref: CAS:573-58-0 {source="KEGG COMPOUND"} xref: CAS:573-58-0 {source="ChemIDplus"} xref: Gmelin:135213 {source="Gmelin"} xref: KEGG:C14078 is_a: CHEBI:48960 ! bis(azo) compound relationship: has_functional_parent CHEBI:38217 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) relationship: has_part CHEBI:38216 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C32H22N6Na2O6S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C32H22N6O6S2.2Na" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IQFVPQOLBLOTPF-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "696.667" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "696.08376" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC(C2=CC=C(N=NC3=CC(=C4C(=C3N)C=CC=C4)S([O-])(=O)=O)C=C2)=CC=C1N=NC5=CC(=C6C(=C5N)C=CC=C6)S([O-])(=O)=O.[Na+].[Na+]" xsd:string [Term] id: CHEBI:3478 name: cefaclor namespace: chebi_ontology alt_id: CHEBI:472656 def: "A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid" RELATED [ChemIDplus] synonym: "7beta-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "CCL" RELATED [KEGG_DRUG] synonym: "Cefaclor" EXACT [KEGG_COMPOUND] synonym: "cefaclor" EXACT [ChEMBL] synonym: "Cefaclor anhydrous" RELATED [ChemIDplus] synonym: "cefaclorum" RELATED INN [DrugBank] synonym: "Cephaclor" RELATED [ChemIDplus] xref: Beilstein:3632473 {source="Beilstein"} xref: CAS:53994-73-3 {source="ChemIDplus"} xref: CAS:53994-73-3 {source="KEGG COMPOUND"} xref: CAS:53994-73-3 {source="DrugBank"} xref: CAS:53994-73-3 {source="KEGG DRUG"} xref: Drug_Central:525 {source="DrugCentral"} xref: DrugBank:DB00833 xref: HMDB:HMDB0014971 xref: KEGG:C06877 xref: KEGG:D00256 xref: LINCS:LSM-5368 xref: Patent:DE2408698 xref: Patent:US3925372 xref: PMID:10230635 {source="ChEMBL"} xref: PMID:10930630 {source="Europe PMC"} xref: PMID:11963587 {source="Europe PMC"} xref: PMID:12485718 {source="Europe PMC"} xref: PMID:12569987 {source="Europe PMC"} xref: PMID:15812119 {source="Europe PMC"} xref: PMID:18969055 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:3632473 {source="Reaxys"} xref: Wikipedia:Cefaclor is_a: CHEBI:23066 ! cephalosporin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H14ClN3O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QYIYFLOTGYLRGG-GPCCPHFNSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "367.80700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "367.03935" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(Cl)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O" xsd:string [Term] id: CHEBI:3499 name: cefotetan namespace: chebi_ontology alt_id: CHEBI:558729 def: "A semi-synthetic second-generation cephamycin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl, methoxy and {[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino groups at the 3, 7alpha, and 7beta positions, respectively, of the cephem skeleton. It is resistant to a wide range of beta-lactamases and is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms." [] subset: 3_STAR synonym: "(6R,7S)-7-(4-(carbamoylcarboxymethylene)-1,3-dithiethane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5- yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- carboxylic acid" RELATED [ChemIDplus] synonym: "(6R,7S)-7-({[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "7beta-({[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino)-7alpha-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Cefotetan" EXACT [KEGG_COMPOUND] synonym: "cefotetan" EXACT [ChEMBL] synonym: "cefotetan" RELATED INN [ChemIDplus] synonym: "cefotetanum" RELATED INN [ChemIDplus] xref: Beilstein:5697364 {source="Beilstein"} xref: CAS:69712-56-7 {source="KEGG COMPOUND"} xref: CAS:69712-56-7 {source="ChemIDplus"} xref: Drug_Central:547 {source="DrugCentral"} xref: DrugBank:DB01330 xref: KEGG:C06886 xref: KEGG:D00260 xref: LINCS:LSM-5961 xref: Patent:DE2824559 xref: Patent:US4263432 xref: PMID:17664321 {source="ChEMBL"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:5697364 {source="Reaxys"} xref: Wikipedia:Cefotetan is_a: CHEBI:55429 ! cephamycin relationship: is_conjugate_acid_of CHEBI:59358 ! cefotetan(2-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H17N7O8S4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SRZNHPXWXCNNDU-IXOPCIAXSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "575.61900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "575.00215" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@]2(NC(=O)C1SC(S1)=C(C(N)=O)C(O)=O)OC)C(O)=O" xsd:string [Term] id: CHEBI:34994 name: teicoplanin A2 namespace: chebi_ontology def: "Any of the glycopeptides whose structure consists of teicoplanin A3-1 in which the hydroxy group of the di(aryloxy)-substituted phenol moiety has been converted to the corresponding 2-acylamino-2-deoxy-beta-D-glucoside. Members of the class differ only in the nature of the acyl group." [] subset: 3_STAR synonym: "teicoplanin A2-*" RELATED [ChEBI] xref: KEGG:C13781 is_a: CHEBI:22160 ! acetamides is_a: CHEBI:24396 ! glycopeptide is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51026 ! macrocycle is_a: CHEBI:83403 ! monochlorobenzenes relationship: has_functional_parent CHEBI:34999 ! teicoplanin A3-1 relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C79H78Cl2N9O33R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1752.414" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1750.40791" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]3NC(=O)[C@H]4NC(=O)[C@@H](Cc5ccc(Oc6cc3cc(Oc3ccc1cc3Cl)c6O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC([*])=O)c(Cl)c5)NC(=O)[C@H](N)c1ccc(O)c(Oc3cc(O)cc4c3)c1)c1ccc(O)c(c1)-c1c(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)cc(O)cc1[C@H](NC2=O)C(O)=O" xsd:string [Term] id: CHEBI:34995 name: teicoplanin A2-1 namespace: chebi_ontology def: "A teicoplanin A2 that has (4Z)-dec-4-enoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "(Z)-34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((1-oxo-4-decenyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "(Z)-34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(1-oxo-4-decenyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 1" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-1" EXACT [KEGG_COMPOUND] xref: CAS:91032-34-7 {source="ChemIDplus"} xref: CAS:91032-34-7 {source="KEGG COMPOUND"} xref: KEGG:C13587 xref: Reaxys:6261779 {source="Reaxys"} is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C88H95Cl2N9O33" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C88H95Cl2N9O33/c1-3-4-5-6-7-8-9-10-60(108)131-78-75(114)72(111)57(31-100)127-85(78)99-67-55-26-40-27-56(67)126-52-18-14-38(24-47(52)90)77(132-87-68(92-34(2)103)73(112)70(109)58(32-101)129-87)69-84(121)97-66(86(122)123)45-29-42(105)30-54(128-88-76(115)74(113)71(110)59(33-102)130-88)61(45)44-23-37(13-15-49(44)106)63(81(118)98-69)95-83(120)65(40)96-82(119)64-39-21-41(104)28-43(22-39)124-53-25-36(12-16-50(53)107)62(91)80(117)93-48(79(116)94-64)20-35-11-17-51(125-55)46(89)19-35/h7-8,11-19,21-30,48,57-59,62-66,68-78,85,87-88,99-102,104-107,109-115H,3-6,9-10,20,31-33,91H2,1-2H3,(H,92,103)(H,93,117)(H,94,116)(H,95,120)(H,96,119)(H,97,121)(H,98,118)(H,122,123)/b8-7-/t48-,57-,58-,59-,62-,63-,64+,65-,66+,68-,69+,70-,71-,72-,73-,74+,75+,76+,77-,78-,85-,87+,88+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGSMSXWFVXNLOG-UCNABHHISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1877.64200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1875.54093" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCC\\C=C/CCC(=O)O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1Nc1c2Oc3ccc(C[C@H]4NC(=O)[C@H](N)c5ccc(O)c(Oc6cc(O)cc(c6)[C@H](NC4=O)C(=O)N[C@@H]4c(c2)cc1Oc1ccc(cc1Cl)[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)[C@@H]1NC(=O)[C@H](NC4=O)c2ccc(O)c(c2)-c2c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)cc(O)cc2[C@H](NC1=O)C(O)=O)c5)cc3Cl" xsd:string [Term] id: CHEBI:34996 name: teicoplanin A2-3 namespace: chebi_ontology def: "A teicoplanin A2 that has decanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 3" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-3" EXACT [KEGG_COMPOUND] xref: CAS:91032-36-9 {source="ChemIDplus"} xref: CAS:91032-36-9 {source="KEGG COMPOUND"} xref: KEGG:C13588 xref: Reaxys:6995259 {source="Reaxys"} is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C88H97Cl2N9O33" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C88H97Cl2N9O33/c1-3-4-5-6-7-8-9-10-60(108)94-68-74(113)71(110)58(32-101)129-87(68)132-78-55-26-40-27-56(78)126-52-18-14-38(24-47(52)90)77(131-86-67(92-34(2)103)73(112)70(109)57(31-100)128-86)69-84(121)98-66(85(122)123)45-29-42(105)30-54(127-88-76(115)75(114)72(111)59(33-102)130-88)61(45)44-23-37(13-15-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-21-41(104)28-43(22-39)124-53-25-36(12-16-50(53)107)62(91)80(117)93-48(79(116)95-64)20-35-11-17-51(125-55)46(89)19-35/h11-19,21-30,48,57-59,62-77,86-88,100-102,104-107,109-115H,3-10,20,31-33,91H2,1-2H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/t48-,57-,58-,59-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71-,72-,73-,74-,75+,76+,77-,86+,87+,88+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BJNLLBUOHPVGFT-PKMGYIMSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1879.65800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1877.55658" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1Oc1c2Oc3ccc(C[C@H]4NC(=O)[C@H](N)c5ccc(O)c(Oc6cc(O)cc(c6)[C@H](NC4=O)C(=O)N[C@@H]4c(c2)cc1Oc1ccc(cc1Cl)[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)[C@@H]1NC(=O)[C@H](NC4=O)c2ccc(O)c(c2)-c2c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)cc(O)cc2[C@H](NC1=O)C(O)=O)c5)cc3Cl" xsd:string [Term] id: CHEBI:34997 name: teicoplanin A2-4 namespace: chebi_ontology def: "A teicoplanin A2 that has 8-methyldecanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((8-methyl-1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(8-methyl-1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 4" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-4" EXACT [KEGG_COMPOUND] xref: CAS:91032-37-0 {source="ChemIDplus"} xref: CAS:91032-37-0 {source="KEGG COMPOUND"} xref: KEGG:C13610 xref: Reaxys:6261978 {source="Reaxys"} is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C89H99Cl2N9O33" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C89H99Cl2N9O33/c1-4-34(2)9-7-5-6-8-10-61(109)95-69-75(114)72(111)59(32-102)130-88(69)133-79-56-26-41-27-57(79)127-53-18-14-39(24-48(53)91)78(132-87-68(93-35(3)104)74(113)71(110)58(31-101)129-87)70-85(122)99-67(86(123)124)46-29-43(106)30-55(128-89-77(116)76(115)73(112)60(33-103)131-89)62(46)45-23-38(13-15-50(45)107)64(82(119)100-70)97-84(121)66(41)98-83(120)65-40-21-42(105)28-44(22-40)125-54-25-37(12-16-51(54)108)63(92)81(118)94-49(80(117)96-65)20-36-11-17-52(126-56)47(90)19-36/h11-19,21-30,34,49,58-60,63-78,87-89,101-103,105-108,110-116H,4-10,20,31-33,92H2,1-3H3,(H,93,104)(H,94,118)(H,95,109)(H,96,117)(H,97,121)(H,98,120)(H,99,122)(H,100,119)(H,123,124)/t34?,49-,58-,59-,60-,63-,64-,65+,66-,67+,68-,69-,70+,71-,72-,73-,74-,75-,76+,77+,78-,87+,88+,89+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KSPOYQQCANXEDC-WNTLLCOUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1893.68500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1891.57223" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC(C)CCCCCCC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1Oc1c2Oc3ccc(C[C@H]4NC(=O)[C@H](N)c5ccc(O)c(Oc6cc(O)cc(c6)[C@H](NC4=O)C(=O)N[C@@H]4c(c2)cc1Oc1ccc(cc1Cl)[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)[C@@H]1NC(=O)[C@H](NC4=O)c2ccc(O)c(c2)-c2c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)cc(O)cc2[C@H](NC1=O)C(O)=O)c5)cc3Cl" xsd:string [Term] id: CHEBI:34998 name: teicoplanin A2-5 namespace: chebi_ontology def: "A teicoplanin A2 that has 9-methyldecanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((9-methyl-1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(9-methyl-1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 5" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-5" EXACT [KEGG_COMPOUND] xref: CAS:91032-38-1 {source="ChemIDplus"} xref: CAS:91032-38-1 {source="KEGG COMPOUND"} xref: KEGG:C13612 xref: Reaxys:6995322 {source="Reaxys"} xref: Reaxys:7509352 {source="Reaxys"} is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C89H99Cl2N9O33" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C89H99Cl2N9O33/c1-34(2)9-7-5-4-6-8-10-61(109)95-69-75(114)72(111)59(32-102)130-88(69)133-79-56-26-41-27-57(79)127-53-18-14-39(24-48(53)91)78(132-87-68(93-35(3)104)74(113)71(110)58(31-101)129-87)70-85(122)99-67(86(123)124)46-29-43(106)30-55(128-89-77(116)76(115)73(112)60(33-103)131-89)62(46)45-23-38(13-15-50(45)107)64(82(119)100-70)97-84(121)66(41)98-83(120)65-40-21-42(105)28-44(22-40)125-54-25-37(12-16-51(54)108)63(92)81(118)94-49(80(117)96-65)20-36-11-17-52(126-56)47(90)19-36/h11-19,21-30,34,49,58-60,63-78,87-89,101-103,105-108,110-116H,4-10,20,31-33,92H2,1-3H3,(H,93,104)(H,94,118)(H,95,109)(H,96,117)(H,97,121)(H,98,120)(H,99,122)(H,100,119)(H,123,124)/t49-,58-,59-,60-,63-,64-,65+,66-,67+,68-,69-,70+,71-,72-,73-,74-,75-,76+,77+,78-,87+,88+,89+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FHBQKTSCJKPYIO-RLDSMAAISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1893.68500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1891.57223" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)CCCCCCCC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1Oc1c2Oc3ccc(C[C@H]4NC(=O)[C@H](N)c5ccc(O)c(Oc6cc(O)cc(c6)[C@H](NC4=O)C(=O)N[C@@H]4c(c2)cc1Oc1ccc(cc1Cl)[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)[C@@H]1NC(=O)[C@H](NC4=O)c2ccc(O)c(c2)-c2c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)cc(O)cc2[C@H](NC1=O)C(O)=O)c5)cc3Cl" xsd:string [Term] id: CHEBI:34999 name: teicoplanin A3-1 namespace: chebi_ontology def: "A glycopeptide consisting of a macropolycyclic heptapeptide in which a phenolic hydroxy group has been converted to its alpha-D-mannoside while a secondary alcohol group has been converted to the corresponding 2-acetamido-2-deoxy-beta-D-glucoside." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teicoplanin A3-1" EXACT [KEGG_COMPOUND] xref: CAS:93616-27-4 {source="KEGG COMPOUND"} xref: CAS:93616-27-4 {source="ChemIDplus"} xref: KEGG:C13613 xref: PMID:1416858 {source="Europe PMC"} xref: Reaxys:6267420 {source="Reaxys"} is_a: CHEBI:22160 ! acetamides is_a: CHEBI:24396 ! glycopeptide is_a: CHEBI:26191 ! polyol is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51026 ! macrocycle is_a: CHEBI:83403 ! monochlorobenzenes relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C72H68Cl2N8O28" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C72H68Cl2N8O28/c1-24(85)76-55-60(93)58(91)47(22-83)108-71(55)110-63-28-5-9-42(37(74)15-28)106-46-18-30-17-45(57(46)90)105-41-8-2-25(10-36(41)73)11-38-64(96)78-52(29-12-31(86)19-33(13-29)104-43-16-26(3-7-40(43)89)50(75)65(97)77-38)67(99)80-53(30)68(100)79-51-27-4-6-39(88)34(14-27)49-35(54(70(102)103)81-69(101)56(63)82-66(51)98)20-32(87)21-44(49)107-72-62(95)61(94)59(92)48(23-84)109-72/h2-10,12-21,38,47-48,50-56,58-63,71-72,83-84,86-95H,11,22-23,75H2,1H3,(H,76,85)(H,77,97)(H,78,96)(H,79,100)(H,80,99)(H,81,101)(H,82,98)(H,102,103)/t38-,47-,48-,50-,51-,52+,53-,54+,55-,56+,58-,59-,60-,61+,62+,63-,71+,72+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SUFIXUDUKRJOBH-JSMFNTJWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1564.25300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1562.35201" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]3NC(=O)[C@H]4NC(=O)[C@@H](Cc5ccc(Oc6cc3cc(Oc3ccc1cc3Cl)c6O)c(Cl)c5)NC(=O)[C@H](N)c1ccc(O)c(Oc3cc(O)cc4c3)c1)c1ccc(O)c(c1)-c1c(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)cc(O)cc1[C@H](NC2=O)C(O)=O" xsd:string [Term] id: CHEBI:35014 name: thiophanate-methyl namespace: chebi_ontology def: "A member of the class of thioureas that is the dimethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould." [] subset: 3_STAR synonym: "1,2-Bis(3-(methoxycarbonyl)-2-thioureido)benzene" RELATED [ChemIDplus] synonym: "1,2-Bis(methoxycarbonylthioureido)benzene" RELATED [ChemIDplus] synonym: "1,2-Di-(3-methoxycarbonyl-2-thioureido)benzene" RELATED [ChemIDplus] synonym: "1,2-Di-(3-methoxycarbonyl-2-thioureido)benzene" RELATED [KEGG_COMPOUND] synonym: "dimethyl (1,2-phenylenedicarbamothioyl)biscarbamate" EXACT IUPAC_NAME [IUPAC] synonym: "dimethyl 4,4'-(o-phenylene)bis(3-thioallophanate)" RELATED [Alan_Wood's_Pesticides] synonym: "dimethyl N,N'-[1,2-phenylenebis(azanediylcarbonothioyl)]dicarbamate" RELATED [Alan_Wood's_Pesticides] synonym: "dimethyl N,N'-[1,2-phenylenebis(iminocarbonothioyl)]bis[carbamate]" RELATED [Alan_Wood's_Pesticides] synonym: "Methyl thiophanate" RELATED [ChemIDplus] synonym: "Methylthiofanate" RELATED [ChemIDplus] synonym: "Methylthiophanate" RELATED [ChemIDplus] synonym: "o-Bis(3-methoxycarbonyl-2-thioureido)benzene" RELATED [ChemIDplus] xref: CAS:23564-05-8 {source="ChemIDplus"} xref: CAS:23564-05-8 {source="KEGG COMPOUND"} xref: KEGG:C14432 xref: Pesticides:thiophanate-methyl {source="Alan Wood's Pesticides"} xref: PMID:22057426 {source="Europe PMC"} xref: PMID:22667099 {source="Europe PMC"} xref: PMID:23242258 {source="Europe PMC"} xref: PMID:23775824 {source="Europe PMC"} xref: PMID:23978278 {source="Europe PMC"} xref: PMID:24256946 {source="Europe PMC"} xref: PMID:24366405 {source="Europe PMC"} xref: PPDB:640 xref: Reaxys:937942 {source="Reaxys"} is_a: CHEBI:51276 ! thioureas is_a: CHEBI:87037 ! benzimidazole precursor fungicide is_a: CHEBI:87061 ! carbamate fungicide relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H14N4O4S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H14N4O4S2/c1-19-11(17)15-9(21)13-7-5-3-4-6-8(7)14-10(22)16-12(18)20-2/h3-6H,1-2H3,(H2,13,15,17,21)(H2,14,16,18,22)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QGHREAKMXXNCOA-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "342.39400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "342.04565" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC" xsd:string [Term] id: CHEBI:3504 name: cefpodoxime namespace: chebi_ontology alt_id: CHEBI:606443 def: "A third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "cefpodoxima" RELATED INN [ChemIDplus] synonym: "cefpodoxime" RELATED INN [ChemIDplus] synonym: "cefpodoximum" RELATED INN [ChemIDplus] xref: Beilstein:6021381 {source="Beilstein"} xref: CAS:80210-62-4 {source="KEGG COMPOUND"} xref: CAS:80210-62-4 {source="ChemIDplus"} xref: DrugBank:DB01416 xref: KEGG:C08114 xref: KEGG:D07650 xref: PMID:20606336 {source="Europe PMC"} xref: PMID:20821175 {source="Europe PMC"} xref: PMID:21395603 {source="Europe PMC"} xref: PMID:21420838 {source="Europe PMC"} xref: PMID:21455420 {source="Europe PMC"} xref: PMID:21509928 {source="Europe PMC"} xref: PMID:21569093 {source="Europe PMC"} xref: PMID:21667000 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:6021381 {source="Reaxys"} xref: VSDB:2968 xref: Wikipedia:Cefpodoxime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:33575 ! carboxylic acid relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17N5O6S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WYUSVOMTXWRGEK-HBWVYFAYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "427.45500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "427.06203" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(COC)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O" xsd:string [Term] id: CHEBI:3505 name: cefpodoxime proxetil namespace: chebi_ontology def: "The 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pharyngitis, and sinusitis." [] subset: 3_STAR synonym: "(RS)-1-((isopropoxycarbonyl)oxy)ethyl (+)-(6R,7R)-7-(2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate" RELATED [ChemIDplus] synonym: "1-{[(propan-2-yloxy)carbonyl]oxy}ethyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "1-{[(propan-2-yloxy)carbonyl]oxy}ethyl 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "cefpodoxime 1-(isopropyloxycarbonyloxy)ethyl ester" RELATED [ChEBI] xref: Beilstein:8174918 {source="Beilstein"} xref: CAS:87239-81-4 {source="ChemIDplus"} xref: CAS:87239-81-4 {source="KEGG COMPOUND"} xref: Drug_Central:555 {source="DrugCentral"} xref: DrugBank:DB01416 xref: KEGG:C08115 xref: KEGG:D00920 xref: Patent:EP49118 xref: Patent:US4486425 is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:33575 ! carboxylic acid relationship: has_functional_parent CHEBI:3504 ! cefpodoxime relationship: has_functional_parent CHEBI:417636 ! 4-{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl}-thiazol-2-yl-ammonium relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50266 ! has role prodrug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H27N5O9S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LTINZAODLRIQIX-FBXRGJNPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "557.59700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "557.12502" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(COC)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(=O)OC(C)OC(=O)OC(C)C" xsd:string [Term] id: CHEBI:3508 name: ceftazidime namespace: chebi_ontology def: "A third-generation cephalosporin antibiotic bearing pyridinium-1-ylmethyl and {[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido groups at positions 3 and 7, respectively, of the cephem skeleton." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-(pyridinium-1-ylmethyl)-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "CAZ" RELATED [KEGG_DRUG] synonym: "ceftazidima" RELATED INN [DrugBank] synonym: "ceftazidime" RELATED INN [KEGG_DRUG] synonym: "Ceftazidime anhydrous" RELATED [ChemIDplus] synonym: "ceftazidimum" RELATED INN [DrugBank] xref: Beilstein:5475149 {source="Beilstein"} xref: CAS:72558-82-8 {source="KEGG DRUG"} xref: CAS:72558-82-8 {source="KEGG COMPOUND"} xref: CAS:72558-82-8 {source="ChemIDplus"} xref: DrugBank:DB00438 xref: KEGG:C06889 xref: KEGG:D07654 xref: Patent:DE2921316 xref: Patent:US4258041 xref: PMID:11252323 {source="Europe PMC"} xref: PMID:11284241 {source="Europe PMC"} xref: PMID:11591698 {source="Europe PMC"} xref: PMID:11605815 {source="Europe PMC"} xref: PMID:11815759 {source="Europe PMC"} xref: PMID:12048030 {source="Europe PMC"} xref: PMID:12120880 {source="Europe PMC"} xref: PMID:12523657 {source="Europe PMC"} xref: PMID:12767750 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:1384868 {source="Europe PMC"} xref: PMID:14961139 {source="Europe PMC"} xref: PMID:15528892 {source="Europe PMC"} xref: PMID:15618675 {source="Europe PMC"} xref: PMID:15687217 {source="Europe PMC"} xref: PMID:15913752 {source="Europe PMC"} xref: PMID:16092041 {source="Europe PMC"} xref: PMID:16501927 {source="Europe PMC"} xref: PMID:16956383 {source="Europe PMC"} xref: PMID:18611568 {source="Europe PMC"} xref: PMID:18926104 {source="Europe PMC"} xref: PMID:19810175 {source="Europe PMC"} xref: PMID:1991925 {source="Europe PMC"} xref: PMID:2068466 {source="Europe PMC"} xref: PMID:24089577 {source="Europe PMC"} xref: PMID:2570956 {source="Europe PMC"} xref: PMID:28543395 {source="Europe PMC"} xref: Reaxys:5475149 {source="Reaxys"} xref: Wikipedia:Ceftazidime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether relationship: is_conjugate_acid_of CHEBI:53676 ! ceftazidime(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50696 ! has role EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H22N6O7S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ORFOPKXBNMVMKC-DWVKKRMSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "546.57600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "546.09914" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(C[n+]3ccccc3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C(O)=O)\\c1csc(N)n1)C([O-])=O" xsd:string [Term] id: CHEBI:35106 name: nitrogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "nitrogen hydrides" RELATED [ChEBI] is_a: CHEBI:35881 ! pnictogen hydride is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35107 name: azane namespace: chebi_ontology def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." [] subset: 3_STAR synonym: "azanes" RELATED [ChEBI] is_a: CHEBI:35106 ! nitrogen hydride [Term] id: CHEBI:35117 name: manganese coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "manganese coordination compounds" RELATED [ChEBI] synonym: "manganese coordination entities" RELATED [ChEBI] synonym: "manganese coordination entity" EXACT [ChEBI] is_a: CHEBI:25154 ! manganese molecular entity is_a: CHEBI:33861 ! transition element coordination entity [Term] id: CHEBI:35131 name: aldose phosphate namespace: chebi_ontology subset: 3_STAR synonym: "aldose phosphates" RELATED [ChEBI] is_a: CHEBI:33447 ! phospho sugar [Term] id: CHEBI:3515 name: cefuroxime namespace: chebi_ontology def: "A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain." [] subset: 3_STAR synonym: "(6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "3-[(carbamoyloxy)methyl]-7beta-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Cefuroxim" RELATED [ChemIDplus] synonym: "Cefuroxime" EXACT [KEGG_COMPOUND] synonym: "cefuroxime" RELATED INN [ChemIDplus] synonym: "cefuroximo" RELATED INN [ChemIDplus] synonym: "cefuroximum" RELATED INN [ChemIDplus] synonym: "Cephuroxime" RELATED [ChemIDplus] synonym: "Sharox" RELATED BRAND_NAME [ChemIDplus] synonym: "Zinacef Danmark" RELATED BRAND_NAME [ChemIDplus] xref: CAS:55268-75-2 {source="KEGG COMPOUND"} xref: CAS:55268-75-2 {source="ChemIDplus"} xref: Drug_Central:565 {source="DrugCentral"} xref: DrugBank:DB01112 xref: KEGG:C06894 xref: KEGG:D00262 xref: MetaCyc:CPD0-2069 xref: Patent:DE2439880 xref: Patent:DE2706413 xref: Patent:US3974153 xref: Patent:US4267320 xref: PMID:11168076 {source="Europe PMC"} xref: PMID:11322179 {source="Europe PMC"} xref: PMID:11581233 {source="Europe PMC"} xref: PMID:12141712 {source="Europe PMC"} xref: PMID:12235459 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:12898829 {source="Europe PMC"} xref: PMID:14658923 {source="Europe PMC"} xref: PMID:15052582 {source="Europe PMC"} xref: PMID:15828440 {source="Europe PMC"} xref: PMID:16341950 {source="Europe PMC"} xref: PMID:17111749 {source="Europe PMC"} xref: PMID:17113884 {source="Europe PMC"} xref: PMID:17261579 {source="Europe PMC"} xref: PMID:17366015 {source="Europe PMC"} xref: PMID:17676080 {source="Europe PMC"} xref: PMID:18208759 {source="Europe PMC"} xref: PMID:18611587 {source="Europe PMC"} xref: PMID:18795089 {source="Europe PMC"} xref: PMID:18931469 {source="Europe PMC"} xref: PMID:19069618 {source="Europe PMC"} xref: PMID:19142482 {source="Europe PMC"} xref: PMID:19411164 {source="Europe PMC"} xref: PMID:21425867 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:5783190 {source="Reaxys"} xref: Wikipedia:Cefuroxime is_a: CHEBI:24129 ! furans is_a: CHEBI:28084 ! 3-(carbamoyloxymethyl)cephalosporin is_a: CHEBI:36816 ! oxime O-ether property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H16N4O8S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JFPVXVDWJQMJEE-IZRZKJBUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "424.38640" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "424.06888" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1ccco1)C(O)=O" xsd:string [Term] id: CHEBI:35175 name: sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "sulfate salts" RELATED [ChEBI] synonym: "sulfates" RELATED [ChEBI] synonym: "sulphate salts" RELATED [ChEBI] synonym: "sulphates" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:26820 ! sulfates [Term] id: CHEBI:35186 name: terpene namespace: chebi_ontology def: "A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2]." [] subset: 3_STAR synonym: "Terpen" RELATED [ChEBI] synonym: "terpene" EXACT [IUPAC] synonym: "terpenes" EXACT IUPAC_NAME [IUPAC] synonym: "terpenes" RELATED [IUPAC] synonym: "terpeno" RELATED [IUPAC] synonym: "terpenos" RELATED [IUPAC] is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:24913 ! isoprenoid [Term] id: CHEBI:35189 name: sesquiterpene namespace: chebi_ontology def: "A C15 terpene." [] subset: 3_STAR synonym: "Sesquiterpen" RELATED [ChEBI] synonym: "sesquiterpenes" EXACT IUPAC_NAME [IUPAC] synonym: "sesquiterpenes" RELATED [IUPAC] synonym: "sesquiterpeno" RELATED [IUPAC] synonym: "sesquiterpenos" RELATED [IUPAC] is_a: CHEBI:35186 ! terpene [Term] id: CHEBI:35190 name: diterpene namespace: chebi_ontology def: "A C20 terpene." [] subset: 3_STAR synonym: "Diterpen" RELATED [ChEBI] synonym: "diterpenes" EXACT IUPAC_NAME [IUPAC] synonym: "diterpenes" RELATED [IUPAC] synonym: "diterpeno" RELATED [IUPAC] synonym: "diterpenos" RELATED [IUPAC] is_a: CHEBI:35186 ! terpene [Term] id: CHEBI:35195 name: surfactant namespace: chebi_ontology def: "A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces." [] subset: 3_STAR synonym: "surface active agent" RELATED [IUPAC] synonym: "surfactant" EXACT IUPAC_NAME [IUPAC] synonym: "surfactants" RELATED [ChEBI] is_a: CHEBI:63046 ! emulsifier [Term] id: CHEBI:35213 name: cyclodepsipeptide namespace: chebi_ontology def: "A depsipeptide in which the amino and hydroxy carboxylic acid residues are connected in a ring." [] subset: 3_STAR synonym: "Cyclodepsipeptid" RELATED [ChEBI] synonym: "cyclodepsipeptides" EXACT IUPAC_NAME [IUPAC] synonym: "Zyklodepsipeptid" RELATED [ChEBI] is_a: CHEBI:23643 ! depsipeptide is_a: CHEBI:25000 ! lactone [Term] id: CHEBI:35221 name: antimetabolite namespace: chebi_ontology def: "A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [] subset: 3_STAR synonym: "antimetabolite" EXACT IUPAC_NAME [IUPAC] synonym: "antimetabolites" RELATED [ChEBI] xref: Wikipedia:Antimetabolite is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:35222 name: inhibitor namespace: chebi_ontology def: "A substance that diminishes the rate of a chemical reaction." [] subset: 3_STAR synonym: "inhibidor" RELATED [ChEBI] synonym: "inhibiteur" RELATED [ChEBI] synonym: "inhibitor" EXACT IUPAC_NAME [IUPAC] synonym: "inhibitors" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:35223 name: catalyst namespace: chebi_ontology def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." [] subset: 3_STAR synonym: "catalizador" RELATED [ChEBI] synonym: "catalyseur" RELATED [ChEBI] synonym: "catalyst" EXACT IUPAC_NAME [IUPAC] synonym: "Katalysator" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:35238 name: amino acid zwitterion namespace: chebi_ontology def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." [] subset: 3_STAR synonym: "amino acid zwitterion" EXACT [ChEBI] is_a: CHEBI:27369 ! zwitterion [Term] id: CHEBI:35243 name: serine zwitterion namespace: chebi_ontology def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of serine." [] subset: 3_STAR synonym: "2-ammonio-3-hydroxypropanoate" EXACT IUPAC_NAME [IUPAC] synonym: "serine zwitterion" EXACT [IUPAC] xref: Beilstein:3935647 {source="Beilstein"} xref: Gmelin:2060272 {source="Gmelin"} is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_tautomer_of CHEBI:17822 ! serine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MTCFGRXMJLQNBG-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "105.09262" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "105.04259" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CO)C([O-])=O" xsd:string [Term] id: CHEBI:35267 name: quaternary ammonium ion namespace: chebi_ontology alt_id: CHEBI:26470 alt_id: CHEBI:8693 def: "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." [] subset: 3_STAR synonym: "a quaternary ammonium" RELATED [UniProt] synonym: "Quaternary amine" RELATED [KEGG_COMPOUND] synonym: "quaternary ammonium ion" EXACT IUPAC_NAME [IUPAC] synonym: "quaternary ammonium ions" RELATED [ChEBI] xref: KEGG:C06703 is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "NR4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "14.00670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*][N+]([*])([*])[*]" xsd:string [Term] id: CHEBI:35274 name: ammonium ion derivative namespace: chebi_ontology def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." [] subset: 3_STAR synonym: "ammonium ion derivatives" RELATED [ChEBI] synonym: "azanium ion derivative" RELATED [ChEBI] synonym: "azanium ion derivatives" RELATED [ChEBI] is_a: CHEBI:33702 ! polyatomic cation is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_parent_hydride CHEBI:28938 ! ammonium [Term] id: CHEBI:35275 name: S-glycosyl compound namespace: chebi_ontology alt_id: CHEBI:22048 alt_id: CHEBI:33577 def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and a S atom bound to a carbon atom, thus creating a C-S bond." [] subset: 3_STAR synonym: "S-glycoside" RELATED [ChEBI] synonym: "S-glycosides" RELATED [ChEBI] synonym: "S-glycosyl compound" EXACT [ChEBI] synonym: "S-glycosyl compounds" RELATED [ChEBI] synonym: "thioglycoside" RELATED [JCBN] synonym: "thioglycosides" RELATED [JCBN] is_a: CHEBI:59793 ! monothioacetal is_a: CHEBI:63161 ! glycosyl compound is_a: CHEBI:73754 ! thiosugar [Term] id: CHEBI:35276 name: ammonium compound namespace: chebi_ontology def: "Compounds (NH4(+))Y(-) and derivatives, in which one or more of the hydrogens bonded to nitrogen have been replaced with univalent groups." [] subset: 3_STAR synonym: "ammonium compounds" RELATED [ChEBI] synonym: "ammonium compounds" RELATED [IUPAC] synonym: "azanium compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_part CHEBI:35274 ! ammonium ion derivative [Term] id: CHEBI:35281 name: onium betaine namespace: chebi_ontology def: "Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." [] subset: 3_STAR synonym: "betaines" EXACT IUPAC_NAME [IUPAC] synonym: "onium betaines" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion [Term] id: CHEBI:35285 name: iminium betaine namespace: chebi_ontology subset: 3_STAR synonym: "iminium betaines" RELATED [ChEBI] is_a: CHEBI:26469 ! quaternary nitrogen compound is_a: CHEBI:35281 ! onium betaine [Term] id: CHEBI:35286 name: iminium ion namespace: chebi_ontology def: "Cations of structure R2C=N(+)R2." [] subset: 3_STAR synonym: "iminium cations" RELATED [ChEBI] synonym: "iminium ion" EXACT [ChEBI] synonym: "iminium ions" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation [Term] id: CHEBI:35293 name: fused compound namespace: chebi_ontology subset: 3_STAR synonym: "fused compounds" RELATED [ChEBI] synonym: "fused polycyclic compounds" RELATED [ChEBI] synonym: "fused-ring polycyclic compound" RELATED [ChEBI] synonym: "fused-ring polycyclic compounds" RELATED [ChEBI] synonym: "polycyclic fused-ring compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound [Term] id: CHEBI:35294 name: carbopolycyclic compound namespace: chebi_ontology def: "A polyclic compound in which all of the ring members are carbon atoms." [] subset: 3_STAR synonym: "carbopolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33598 ! carbocyclic compound is_a: CHEBI:35295 ! homopolycyclic compound [Term] id: CHEBI:35295 name: homopolycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "homopolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33597 ! homocyclic compound is_a: CHEBI:33635 ! polycyclic compound [Term] id: CHEBI:35296 name: ortho-fused polycyclic arene namespace: chebi_ontology subset: 3_STAR synonym: "ortho-fused polycyclic arenes" RELATED [ChEBI] is_a: CHEBI:33848 ! polycyclic arene is_a: CHEBI:35427 ! ortho-fused polycyclic hydrocarbon [Term] id: CHEBI:35297 name: acene namespace: chebi_ontology def: "A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement." [] subset: 3_STAR synonym: "Acen" RELATED [ChEBI] synonym: "acene" EXACT [IUPAC] synonym: "acenes" EXACT IUPAC_NAME [IUPAC] synonym: "Azen" RELATED [ChEBI] synonym: "polyacenes" RELATED [ChEBI] xref: Wikipedia:Acene is_a: CHEBI:35296 ! ortho-fused polycyclic arene is_a: CHEBI:51269 ! acenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H8.(C4H2)n" xsd:string [Term] id: CHEBI:35312 name: pentoside namespace: chebi_ontology subset: 3_STAR synonym: "pentoside" EXACT [ChEBI] synonym: "pentosides" RELATED [ChEBI] is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:35313 name: hexoside namespace: chebi_ontology subset: 3_STAR synonym: "hexoside" EXACT [ChEBI] synonym: "hexosides" RELATED [ChEBI] is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:3534 name: cephalexin namespace: chebi_ontology def: "A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid" RELATED [ChemIDplus] synonym: "7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid" RELATED [ChemIDplus] synonym: "7beta-[(2R)-2-amino-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Cefalexin" RELATED [KEGG_COMPOUND] synonym: "cefalexina" RELATED INN [ChemIDplus] synonym: "cefalexine" RELATED INN [ChemIDplus] synonym: "cefalexinum" RELATED INN [ChemIDplus] synonym: "Celexin" RELATED [ChemIDplus] synonym: "Cepastar" RELATED [ChemIDplus] synonym: "Cepexin" RELATED [ChemIDplus] synonym: "Cephacillin" RELATED [ChemIDplus] synonym: "Ceporexin" RELATED [ChemIDplus] synonym: "CEX" RELATED [KEGG_DRUG] xref: Beilstein:965503 {source="Beilstein"} xref: CAS:15686-71-2 {source="KEGG COMPOUND"} xref: CAS:15686-71-2 {source="ChemIDplus"} xref: Drug_Central:571 {source="DrugCentral"} xref: DrugBank:DB00567 xref: HMDB:HMDB0014707 xref: KEGG:C06895 xref: KEGG:D00263 xref: LINCS:LSM-5957 xref: Patent:US3275626 xref: Patent:US3507861 xref: PMID:10930630 {source="Europe PMC"} xref: PMID:12569987 {source="Europe PMC"} xref: PMID:12833570 {source="Europe PMC"} xref: PMID:1384868 {source="Europe PMC"} xref: PMID:2083978 {source="Europe PMC"} xref: PMID:22559990 {source="Europe PMC"} xref: PMID:23061564 {source="Europe PMC"} xref: PMID:23457080 {source="Europe PMC"} xref: PMID:23545436 {source="Europe PMC"} xref: PMID:23688276 {source="Europe PMC"} xref: PMID:23811740 {source="Europe PMC"} xref: PMID:24268227 {source="Europe PMC"} xref: PMID:24548092 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:4238892 {source="Reaxys"} xref: VSDB:1791 xref: Wikipedia:Cefalexin is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_conjugate_acid_of CHEBI:59392 ! cephalexin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H17N3O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZAIPMKNFIOOWCQ-UEKVPHQBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "347.38900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "347.09398" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O" xsd:string [Term] id: CHEBI:35341 name: steroid namespace: chebi_ontology alt_id: CHEBI:13687 alt_id: CHEBI:26768 alt_id: CHEBI:9263 def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." [] subset: 3_STAR synonym: "a steroid" RELATED [UniProt] synonym: "Steroid" EXACT [KEGG_COMPOUND] synonym: "steroids" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00377 xref: MetaCyc:Steroids is_a: CHEBI:18059 ! lipid is_a: CHEBI:51958 ! organic polycyclic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "259.450" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "259.24258" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCCC4)C" xsd:string [Term] id: CHEBI:35350 name: hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:24748 alt_id: CHEBI:5814 subset: 3_STAR synonym: "hydroxy steroids" RELATED [ChEBI] synonym: "Hydroxysteroid" RELATED [KEGG_COMPOUND] synonym: "hydroxysteroids" RELATED [ChEBI] xref: KEGG:C02159 is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:35341 ! steroid [Term] id: CHEBI:35352 name: organonitrogen compound namespace: chebi_ontology def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." [] subset: 3_STAR synonym: "organonitrogen compounds" EXACT IUPAC_NAME [IUPAC] synonym: "organonitrogens" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35356 name: dicarboximide namespace: chebi_ontology def: "An imide in which the two acyl substituents on nitrogen are carboacyl groups." [] subset: 3_STAR synonym: "dicarboximides" RELATED [ChEBI] is_a: CHEBI:24782 ! imide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2NO2R3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "70.027" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "69.99290" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N(C([*])=O)C([*])=O" xsd:string [Term] id: CHEBI:35358 name: sulfonamide namespace: chebi_ontology def: "An amide of a sulfonic acid RS(=O)2NR'2." [] subset: 3_STAR synonym: "sulfonamides" EXACT IUPAC_NAME [IUPAC] synonym: "sulfonamides" RELATED [ChEBI] xref: PMID:11498380 {source="Europe PMC"} xref: PMID:2434548 {source="Europe PMC"} xref: PMID:26811268 {source="Europe PMC"} xref: PMID:26832216 {source="Europe PMC"} xref: Wikipedia:Sulfonamide is_a: CHEBI:33256 ! primary amide is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:33552 ! sulfonic acid derivative property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "NO2SR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "78.07100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "77.96497" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]S(=O)(=O)N([*])[*]" xsd:string [Term] id: CHEBI:35359 name: carboxamidine namespace: chebi_ontology def: "Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom." [] subset: 3_STAR synonym: "Amidines" RELATED [KEGG_COMPOUND] synonym: "carboxamidines" EXACT IUPAC_NAME [IUPAC] synonym: "carboxamidines" RELATED [ChEBI] xref: KEGG:C06060 is_a: CHEBI:2634 ! amidine is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:35362 name: hydrazide namespace: chebi_ontology def: "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC)." [] subset: 3_STAR synonym: "hydrazides" EXACT IUPAC_NAME [IUPAC] synonym: "hydrazides" RELATED [ChEBI] is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35363 name: carbohydrazide namespace: chebi_ontology def: "A hydrazide consisting of hydrazine carrying one or more carboacyl groups." [] subset: 3_STAR synonym: "carbohydrazides" EXACT IUPAC_NAME [IUPAC] synonym: "carbohydrazides" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:35362 ! hydrazide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CN2OR4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "56.024" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "56.00106" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(*)=O)(N(*)*)*" xsd:string [Term] id: CHEBI:35366 name: fatty acid namespace: chebi_ontology alt_id: CHEBI:13633 alt_id: CHEBI:24024 alt_id: CHEBI:4984 def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." [] subset: 3_STAR synonym: "acide gras" RELATED [ChEBI] synonym: "acides gras" RELATED [ChemIDplus] synonym: "acido graso" RELATED [ChEBI] synonym: "acidos grasos" RELATED [ChEBI] synonym: "Fatty acid" EXACT [KEGG_COMPOUND] synonym: "fatty acids" EXACT IUPAC_NAME [IUPAC] synonym: "fatty acids" RELATED [ChEBI] synonym: "Fettsaeure" RELATED [ChEBI] synonym: "Fettsaeuren" RELATED [ChEBI] xref: KEGG:C00162 xref: PMID:14287444 {source="Europe PMC"} xref: PMID:14300208 {source="Europe PMC"} xref: PMID:14328676 {source="Europe PMC"} xref: Wikipedia:Fatty_acid is_a: CHEBI:18059 ! lipid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:28868 ! fatty acid anion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01740" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string [Term] id: CHEBI:35381 name: monosaccharide namespace: chebi_ontology alt_id: CHEBI:25407 alt_id: CHEBI:6984 def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." [] subset: 3_STAR synonym: "monosacarido" RELATED [ChEBI] synonym: "monosacaridos" RELATED [IUPAC] synonym: "Monosaccharid" RELATED [ChEBI] synonym: "Monosaccharide" EXACT [KEGG_COMPOUND] synonym: "monosaccharides" EXACT IUPAC_NAME [IUPAC] synonym: "Monosacharid" RELATED [ChEBI] xref: KEGG:C06698 is_a: CHEBI:16646 ! carbohydrate [Term] id: CHEBI:35406 name: oxoanion namespace: chebi_ontology alt_id: CHEBI:33274 alt_id: CHEBI:33436 def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." [] subset: 3_STAR synonym: "oxoacid anions" RELATED [ChEBI] synonym: "oxoanion" EXACT [ChEBI] synonym: "oxoanions" RELATED [ChEBI] is_a: CHEBI:25741 ! oxide is_a: CHEBI:33273 ! polyatomic anion [Term] id: CHEBI:35410 name: primary diamine namespace: chebi_ontology alt_id: CHEBI:26264 alt_id: CHEBI:8408 def: "A primary diamine is a compound derived from a hydrocarbon by replacing two hydrogen atoms by amino groups." [] subset: 3_STAR synonym: "Primary diamine" EXACT [KEGG_COMPOUND] synonym: "primary diamines" EXACT IUPAC_NAME [IUPAC] synonym: "primary diamines" RELATED [ChEBI] xref: KEGG:C02311 is_a: CHEBI:23666 ! diamine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H4N2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "32.045" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.03745" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[*]N" xsd:string [Term] id: CHEBI:35411 name: alkane-alpha,omega-diamine namespace: chebi_ontology alt_id: CHEBI:10204 alt_id: CHEBI:13775 alt_id: CHEBI:13808 alt_id: CHEBI:22316 alt_id: CHEBI:2577 def: "A primary diamine that is ethane or a higher alkane in which a hydrogen of each of the terminal methyl groups has been replaced by an amino group. H2NCH2(CH2)nCH2NH2, where n = 0, 1, 2, etc." [] subset: 3_STAR synonym: "Alkane-alpha,omega-diamine" EXACT [KEGG_COMPOUND] synonym: "alkane-alpha,omega-diamines" RELATED [ChEBI] synonym: "alpha,omega-Diamine" RELATED [KEGG_COMPOUND] xref: KEGG:C02896 xref: KEGG:C03687 is_a: CHEBI:35410 ! primary diamine is_a: CHEBI:46687 ! diazaalkane relationship: is_conjugate_base_of CHEBI:70977 ! alkane-alpha,omega-diammonium(2+) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(CH2)n.C2H8N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H4N2(CH2)n" xsd:string [Term] id: CHEBI:35427 name: ortho-fused polycyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR synonym: "ortho-fused polycyclic hydrocarbon" EXACT [ChEBI] synonym: "ortho-fused polycyclic hydrocarbons" RELATED [ChEBI] is_a: CHEBI:33637 ! ortho-fused compound [Term] id: CHEBI:35436 name: D-glucoside namespace: chebi_ontology alt_id: CHEBI:21009 alt_id: CHEBI:4173 def: "Any glucoside in which the glycoside group is derived from D-glucose." [] subset: 3_STAR synonym: "a D-glucoside" RELATED [UniProt] synonym: "D-Glucoside" EXACT [KEGG_COMPOUND] synonym: "D-glucosides" RELATED [ChEBI] xref: KEGG:C01798 is_a: CHEBI:24278 ! glucoside property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H11O6R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "179.148" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "179.05556" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H]1(OC([C@H](O)[C@H]([C@@H]1O)O)O*)CO" xsd:string [Term] id: CHEBI:35441 name: antiinfective agent namespace: chebi_ontology def: "A substance used in the prophylaxis or therapy of infectious diseases." [] subset: 3_STAR synonym: "anti-infective agents" RELATED [ChEBI] synonym: "anti-infective drugs" RELATED [ChEBI] synonym: "antiinfective agents" RELATED [ChEBI] synonym: "antiinfective drug" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35442 name: antiparasitic agent namespace: chebi_ontology def: "A substance used to treat or prevent parasitic infections." [] subset: 3_STAR synonym: "antiparasitic drugs" RELATED [ChEBI] synonym: "antiparasitics" RELATED [ChEBI] synonym: "parasiticides" RELATED [ChEBI] xref: Wikipedia:Antiparasitic is_a: CHEBI:35441 ! antiinfective agent [Term] id: CHEBI:35443 name: anthelminthic drug namespace: chebi_ontology def: "Substance intended to kill parasitic worms (helminths)." [] subset: 3_STAR synonym: "anthelminthic" EXACT IUPAC_NAME [IUPAC] synonym: "anthelminthics" RELATED [ChEBI] synonym: "anthelmintic" RELATED [IUPAC] synonym: "anthelmintics" RELATED [ChEBI] synonym: "antihelminth" RELATED [ChEBI] synonym: "antihelmintico" RELATED [ChEBI] synonym: "vermifuge" RELATED [ChEBI] is_a: CHEBI:35442 ! antiparasitic agent [Term] id: CHEBI:35444 name: antinematodal drug namespace: chebi_ontology def: "A substance used in the treatment or control of nematode infestations." [] subset: 3_STAR synonym: "antinematodal agent" RELATED [ChEBI] synonym: "antinematodal drugs" RELATED [ChEBI] synonym: "antinematodals" RELATED [ChEBI] is_a: CHEBI:25491 ! nematicide is_a: CHEBI:35443 ! anthelminthic drug [Term] id: CHEBI:35470 name: central nervous system drug namespace: chebi_ontology def: "A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system." [] subset: 3_STAR synonym: "central nervous system agents" RELATED [ChEBI] synonym: "CNS agent" RELATED [ChEBI] synonym: "CNS drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35472 name: anti-inflammatory drug namespace: chebi_ontology def: "A substance that reduces or suppresses inflammation." [] subset: 3_STAR synonym: "anti-inflammatory drugs" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory drug" RELATED [ChEBI] synonym: "antiinflammatory drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:67079 ! anti-inflammatory agent [Term] id: CHEBI:35475 name: non-steroidal anti-inflammatory drug namespace: chebi_ontology def: "An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." [] subset: 3_STAR synonym: "non-steroidal anti-inflammatory agent" RELATED [ChEBI] synonym: "non-steroidal anti-inflammatory drugs" RELATED [ChEBI] synonym: "NSAID" RELATED [ChEBI] synonym: "NSAIDs" RELATED [ChEBI] xref: Wikipedia:Non-steroidal_anti-inflammatory_drug is_a: CHEBI:35472 ! anti-inflammatory drug is_a: CHEBI:35842 ! antirheumatic drug [Term] id: CHEBI:35479 name: alkali metal salt namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal salts" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:33296 ! alkali metal molecular entity [Term] id: CHEBI:35488 name: central nervous system depressant namespace: chebi_ontology def: "A loosely defined group of drugs that tend to reduce the activity of the central nervous system." [] subset: 3_STAR synonym: "central nervous system depressants" RELATED [ChEBI] synonym: "CNS depressants" RELATED [ChEBI] is_a: CHEBI:35470 ! central nervous system drug [Term] id: CHEBI:35489 name: organic disulfide namespace: chebi_ontology def: "Compounds of structure RSSR in which R and R' are organic groups." [] subset: 3_STAR synonym: "an organic disulfide" RELATED [UniProt] synonym: "disulfides" EXACT IUPAC_NAME [IUPAC] synonym: "organic disulfides" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:48343 ! disulfide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "S2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "64.13000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "63.94414" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]SS[*]" xsd:string [Term] id: CHEBI:35496 name: fluorobenzenes namespace: chebi_ontology def: "Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:37143 ! organofluorine compound [Term] id: CHEBI:35497 name: androgen antagonist namespace: chebi_ontology def: "A compound which inhibits or antagonises the biosynthesis or actions of androgens." [] subset: 3_STAR synonym: "antiandrogen" RELATED [ChEBI] xref: Wikipedia:Antiandrogen is_a: CHEBI:49020 ! hormone antagonist [Term] id: CHEBI:35498 name: diuretic namespace: chebi_ontology def: "An agent that promotes the excretion of urine through its effects on kidney function." [] subset: 3_STAR synonym: "diuretics" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35507 name: natural product fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "natural product fundamental parents" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:35508 name: steroid fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "steroid fundamental parents" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:35507 ! natural product fundamental parent [Term] id: CHEBI:35515 name: 5alpha-cholestane namespace: chebi_ontology alt_id: CHEBI:20650 def: "The 5alpha-stereoisomer of cholestane." [] subset: 3_STAR synonym: "(5alpha)-cholestane" RELATED [NIST_Chemistry_WebBook] synonym: "5alpha-cholestane" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-cholestane" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:2051806 {source="Beilstein"} xref: CAS:481-21-0 {source="NIST Chemistry WebBook"} xref: CAS:481-21-0 {source="ChemIDplus"} xref: HMDB:HMDB0041632 xref: Reaxys:2051806 {source="Reaxys"} is_a: CHEBI:35516 ! cholestane property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H48" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H48/c1-19(2)9-8-10-20(3)23-14-15-24-22-13-12-21-11-6-7-17-26(21,4)25(22)16-18-27(23,24)5/h19-25H,6-18H2,1-5H3/t20-,21-,22+,23-,24+,25+,26+,27-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XIIAYQZJNBULGD-XWLABEFZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "372.67002" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "372.37560" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCCC(C)C" xsd:string [Term] id: CHEBI:35516 name: cholestane namespace: chebi_ontology subset: 3_STAR synonym: "cholestane" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:5334741 {source="Beilstein"} xref: CAS:14982-53-7 {source="NIST Chemistry WebBook"} xref: CAS:14982-53-7 {source="ChemIDplus"} xref: LIPID_MAPS_instance:LMST01010000 {source="LIPID MAPS"} xref: Wikipedia:Cholestane is_a: CHEBI:35508 ! steroid fundamental parent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H48" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H48/c1-19(2)9-8-10-20(3)23-14-15-24-22-13-12-21-11-6-7-17-26(21,4)25(22)16-18-27(23,24)5/h19-25H,6-18H2,1-5H3/t20-,21?,22+,23-,24+,25+,26+,27-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XIIAYQZJNBULGD-LDHZKLTISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "372.67002" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "372.37560" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C" xsd:string [Term] id: CHEBI:35526 name: hypoglycemic agent namespace: chebi_ontology def: "A drug which lowers the blood glucose level." [] subset: 3_STAR synonym: "antidiabetic" RELATED [ChEBI] synonym: "antihyperglycemic" RELATED [ChEBI] synonym: "antihyperglycemic agent" RELATED [ChEBI] synonym: "antihyperglycemic agents" RELATED [ChEBI] synonym: "antihyperglycemic drug" RELATED [ChEBI] synonym: "antihyperglycemic drugs" RELATED [ChEBI] synonym: "antihyperglycemics" RELATED [ChEBI] synonym: "hypoglycemic agents" RELATED [ChEBI] synonym: "hypoglycemic drug" RELATED [ChEBI] synonym: "hypoglycemic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35550 name: 1H-1,2,4-triazole namespace: chebi_ontology subset: 3_STAR synonym: "1H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] synonym: "s-Triazole" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:104767 {source="Beilstein"} xref: CAS:288-88-0 {source="NIST Chemistry WebBook"} xref: Gmelin:122679 {source="Gmelin"} is_a: CHEBI:35560 ! 1,2,4-triazole relationship: is_tautomer_of CHEBI:35561 ! 3H-1,2,4-triazole relationship: is_tautomer_of CHEBI:46077 ! 4H-1,2,4-triazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3N3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H3N3/c1-3-2-5-4-1/h1-2H,(H,3,4,5)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NSPMIYGKQJPBQR-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "69.06544" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "69.03270" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1nc[nH]n1" xsd:string [Term] id: CHEBI:35552 name: heterocyclic organic fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "heterocyclic fundamental parent" RELATED [ChEBI] synonym: "heterocyclic organic fundamental parents" RELATED [ChEBI] synonym: "heterocyclic parent hydrides" EXACT IUPAC_NAME [IUPAC] synonym: "organic heterocyclic fundamental parents" RELATED [ChEBI] is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:35554 name: cardiovascular drug namespace: chebi_ontology def: "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." [] subset: 3_STAR synonym: "cardiovascular agent" RELATED [ChEBI] synonym: "cardiovascular drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35555 name: mancude organic heteromonocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "mancude organic heteromonocyclic parents" RELATED [ChEBI] synonym: "mancude-ring organic heteromonocyclic parents" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:35571 ! mancude organic heterocyclic parent [Term] id: CHEBI:35560 name: 1,2,4-triazole namespace: chebi_ontology subset: 3_STAR synonym: "1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] xref: DrugBank:DB03594 is_a: CHEBI:38597 ! triazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3N3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "69.065" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "69.03270" xsd:string [Term] id: CHEBI:35561 name: 3H-1,2,4-triazole namespace: chebi_ontology subset: 3_STAR synonym: "3H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:506536 {source="Beilstein"} xref: Gmelin:362238 {source="Gmelin"} is_a: CHEBI:35560 ! 1,2,4-triazole relationship: is_tautomer_of CHEBI:35550 ! 1H-1,2,4-triazole relationship: is_tautomer_of CHEBI:46077 ! 4H-1,2,4-triazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3N3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H3N3/c1-3-2-5-4-1/h1H,2H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FFGRBWANQMLTQI-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "69.06544" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "69.03270" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1N=CN=N1" xsd:string [Term] id: CHEBI:35568 name: mancude ring namespace: chebi_ontology def: "Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds." [] subset: 3_STAR synonym: "mancude rings" RELATED [ChEBI] synonym: "mancude-ring systems" EXACT IUPAC_NAME [IUPAC] synonym: "mancunide-ring systems" RELATED [IUPAC] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:35570 name: mancude organic heterobicyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "mancude organic heterobicyclic parents" RELATED [ChEBI] synonym: "mancude-ring organic heterobicyclic parents" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:35571 ! mancude organic heterocyclic parent [Term] id: CHEBI:35571 name: mancude organic heterocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "mancude organic heterocyclic parents" RELATED [ChEBI] synonym: "mancude-ring organic heterocyclic parents" RELATED [ChEBI] is_a: CHEBI:35552 ! heterocyclic organic fundamental parent is_a: CHEBI:35573 ! organic mancude parent [Term] id: CHEBI:35573 name: organic mancude parent namespace: chebi_ontology subset: 3_STAR synonym: "organic mancude parents" RELATED [ChEBI] synonym: "organic mancude-ring parents" RELATED [ChEBI] is_a: CHEBI:33245 ! organic fundamental parent is_a: CHEBI:35568 ! mancude ring [Term] id: CHEBI:35604 name: carbon oxoanion namespace: chebi_ontology def: "A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." [] subset: 3_STAR synonym: "carbon oxoanion" EXACT [ChEBI] synonym: "carbon oxoanions" RELATED [ChEBI] synonym: "oxocarbon anion" RELATED [ChEBI] synonym: "oxocarbon anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35605 name: carbon oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "carbon oxoacids" RELATED [ChEBI] synonym: "oxoacids of carbon" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35610 name: antineoplastic agent namespace: chebi_ontology def: "A substance that inhibits or prevents the proliferation of neoplasms." [] subset: 3_STAR synonym: "anticancer agent" RELATED [ChEBI] synonym: "anticancer agents" RELATED [ChEBI] synonym: "antineoplastic" RELATED [ChEBI] synonym: "antineoplastic agents" RELATED [ChEBI] synonym: "cytostatic" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35618 name: aromatic ether namespace: chebi_ontology def: "Any ether in which the oxygen is attached to at least one aryl substituent." [] subset: 3_STAR is_a: CHEBI:25698 ! ether is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:35620 name: vasodilator agent namespace: chebi_ontology def: "A drug used to cause dilation of the blood vessels." [] subset: 3_STAR synonym: "vasodilator" RELATED [ChEBI] synonym: "vasodilator agents" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:35622 name: thiazolidines namespace: chebi_ontology subset: 3_STAR synonym: "thiazolidine" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:35623 name: anticonvulsant namespace: chebi_ontology def: "A drug used to prevent seizures or reduce their severity." [] subset: 3_STAR synonym: "anti-convulsant" RELATED [ChEBI] synonym: "anti-convulsants" RELATED [ChEBI] synonym: "anti-convulsive agent" RELATED [ChEBI] synonym: "anti-convulsive agents" RELATED [ChEBI] synonym: "anticonvulsants" RELATED [ChEBI] synonym: "anticonvulsive agent" RELATED [ChEBI] synonym: "anticonvulsive agents" RELATED [ChEBI] synonym: "antiepileptic" RELATED [ChEBI] synonym: "antiepileptics" RELATED [ChEBI] synonym: "Antiepileptika" RELATED [ChEBI] synonym: "Antiepileptikum" RELATED [ChEBI] synonym: "antiepileptique" RELATED [ChEBI] synonym: "antiepileptiques" RELATED [ChEBI] synonym: "Antikonvulsiva" RELATED [ChEBI] synonym: "Antikonvulsivum" RELATED [ChEBI] is_a: CHEBI:35488 ! central nervous system depressant [Term] id: CHEBI:35625 name: EC 3.5.2.6 (beta-lactamase) inhibitor namespace: chebi_ontology def: "An EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor that interferes with the action of beta-lactamase (EC 3.5.2.6)." [] subset: 3_STAR synonym: "ampicillinase inhibitor" RELATED [ChEBI] synonym: "ampicillinase inhibitors" RELATED [ChEBI] synonym: "beta-lactam hydrolase inhibitor" RELATED [ChEBI] synonym: "beta-lactam hydrolase inhibitors" RELATED [ChEBI] synonym: "beta-lactamase (EC 3.5.2.6) inhibitor" RELATED [ChEBI] synonym: "beta-lactamase (EC 3.5.2.6) inhibitors" RELATED [ChEBI] synonym: "beta-lactamase A, B, C inhibitor" RELATED [ChEBI] synonym: "beta-lactamase A, B, C inhibitors" RELATED [ChEBI] synonym: "beta-lactamase AME I inhibitor" RELATED [ChEBI] synonym: "beta-lactamase AME I inhibitors" RELATED [ChEBI] synonym: "beta-lactamase I-III inhibitor" RELATED [ChEBI] synonym: "beta-lactamase I-III inhibitors" RELATED [ChEBI] synonym: "beta-lactamase inhibitor" RELATED [ChEBI] synonym: "beta-lactamase inhibitors" RELATED [ChEBI] synonym: "cephalosporin-beta-lactamase inhibitor" RELATED [ChEBI] synonym: "cephalosporin-beta-lactamase inhibitors" RELATED [ChEBI] synonym: "cephalosporinase inhibitor" RELATED [ChEBI] synonym: "cephalosporinase inhibitors" RELATED [ChEBI] synonym: "EC 3.5.2.6 (beta-lactamase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.2.6 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.2.6 inhibitors" RELATED [ChEBI] synonym: "exopenicillinase inhibitor" RELATED [ChEBI] synonym: "exopenicillinase inhibitors" RELATED [ChEBI] synonym: "neutrapen inhibitor" RELATED [ChEBI] synonym: "neutrapen inhibitors" RELATED [ChEBI] synonym: "penicillin amido-beta-lactamhydrolase inhibitor" RELATED [ChEBI] synonym: "penicillin amido-beta-lactamhydrolase inhibitors" RELATED [ChEBI] synonym: "penicillin beta-lactamase inhibitor" RELATED [ChEBI] synonym: "penicillin beta-lactamase inhibitors" RELATED [ChEBI] synonym: "penicillinase I, II inhibitor" RELATED [ChEBI] synonym: "penicillinase I, II inhibitors" RELATED [ChEBI] synonym: "penicillinase inhibitor" RELATED [ChEBI] synonym: "penicillinase inhibitors" RELATED [ChEBI] is_a: CHEBI:76808 ! EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor [Term] id: CHEBI:35627 name: beta-lactam namespace: chebi_ontology alt_id: CHEBI:10426 alt_id: CHEBI:13203 alt_id: CHEBI:22845 def: "A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon." [] subset: 3_STAR synonym: "a beta-lactam" RELATED [UniProt] synonym: "beta-Lactam" EXACT [KEGG_COMPOUND] synonym: "beta-lactams" RELATED [ChEBI] xref: KEGG:C01866 xref: Wikipedia:Beta-lactam is_a: CHEBI:24995 ! lactam property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H2NOR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "68.054" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "68.01364" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(C(N(*)C1*)=O)*" xsd:string [Term] id: CHEBI:35674 name: antihypertensive agent namespace: chebi_ontology def: "Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism." [] subset: 3_STAR synonym: "antihypertensive" RELATED [ChEBI] synonym: "antihypertensive agents" RELATED [ChEBI] synonym: "antihypertensive drug" RELATED [ChEBI] synonym: "antihypertensive drugs" RELATED [ChEBI] xref: Wikipedia:Antihypertensive_drug is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:35679 name: antilipemic drug namespace: chebi_ontology def: "A substance used to treat hyperlipidemia (an excess of lipids in the blood)." [] subset: 3_STAR synonym: "antihyperlipemic" RELATED [ChEBI] synonym: "antihyperlipemics" RELATED [ChEBI] synonym: "antihyperlipidaemic agent" RELATED [ChEBI] synonym: "antihyperlipidaemic agents" RELATED [ChEBI] synonym: "antihyperlipidaemic drug" RELATED [ChEBI] synonym: "antihyperlipidaemic drugs" RELATED [ChEBI] synonym: "antihyperlipidemic" RELATED [ChEBI] synonym: "antihyperlipidemic agent" RELATED [ChEBI] synonym: "antihyperlipidemic agents" RELATED [ChEBI] synonym: "antihyperlipidemic drug" RELATED [ChEBI] synonym: "antihyperlipidemic drugs" RELATED [ChEBI] synonym: "antihyperlipidemics" RELATED [ChEBI] synonym: "antilipemic" RELATED [ChEBI] synonym: "antilipemic drugs" RELATED [ChEBI] synonym: "antilipemics" RELATED [ChEBI] synonym: "hypolipidemic agent" RELATED [ChEBI] synonym: "hypolipidemic agents" RELATED [ChEBI] synonym: "lipid-lowering agent" RELATED [ChEBI] synonym: "lipid-lowering agents" RELATED [ChEBI] synonym: "lipid-lowering drug" RELATED [ChEBI] synonym: "lipid-lowering drugs" RELATED [ChEBI] xref: Wikipedia:Hypolipidemic_agent is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35681 name: secondary alcohol namespace: chebi_ontology alt_id: CHEBI:13425 alt_id: CHEBI:13686 alt_id: CHEBI:26617 alt_id: CHEBI:58662 alt_id: CHEBI:8741 alt_id: CHEBI:9077 def: "A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it." [] subset: 3_STAR synonym: "a secondary alcohol" RELATED [UniProt] synonym: "R-CHOH-R'" RELATED [KEGG_COMPOUND] synonym: "Secondary alcohol" EXACT [KEGG_COMPOUND] synonym: "secondary alcohols" RELATED [ChEBI] xref: KEGG:C00432 xref: KEGG:C01612 is_a: CHEBI:30879 ! alcohol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2OR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "30.026" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.01056" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(*)O" xsd:string [Term] id: CHEBI:35689 name: tetrazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains four N atoms and one C atom." [] subset: 3_STAR is_a: CHEBI:68452 ! azole [Term] id: CHEBI:35692 name: dicarboxylic acid namespace: chebi_ontology alt_id: CHEBI:23692 alt_id: CHEBI:36172 alt_id: CHEBI:4501 def: "Any carboxylic acid containing two carboxy groups." [] subset: 3_STAR synonym: "Dicarboxylic acid" EXACT [KEGG_COMPOUND] synonym: "dicarboxylic acids" RELATED [ChEBI] xref: KEGG:C02028 is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion [Term] id: CHEBI:35693 name: dicarboxylic acid anion namespace: chebi_ontology subset: 3_STAR synonym: "dicarboxylic acid anion" EXACT [ChEBI] synonym: "dicarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid [Term] id: CHEBI:35695 name: dicarboxylic acid monoanion namespace: chebi_ontology def: "Any dicarboxylic acid anion that is a monoanion obtained by the deprotonation of only one of the carboxy groups of the dicarboxylic acid." [] subset: 3_STAR synonym: "dicarboxylic acid monoanions" RELATED [ChEBI] is_a: CHEBI:35693 ! dicarboxylic acid anion [Term] id: CHEBI:35701 name: ester namespace: chebi_ontology alt_id: CHEBI:23960 alt_id: CHEBI:4859 def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." [] subset: 3_STAR synonym: "Ester" EXACT [KEGG_COMPOUND] synonym: "esters" RELATED [ChEBI] xref: KEGG:C00287 xref: Wikipedia:Ester is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35703 name: xenobiotic namespace: chebi_ontology alt_id: CHEBI:10074 alt_id: CHEBI:27333 def: "A xenobiotic (Greek, xenos \"foreign\"; bios \"life\") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means." [] subset: 3_STAR synonym: "Xenobiotic" EXACT [KEGG_COMPOUND] synonym: "xenobiotic" EXACT IUPAC_NAME [IUPAC] synonym: "xenobiotic compounds" RELATED [ChEBI] synonym: "xenobiotics" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C06708 xref: Wikipedia:Xenobiotic is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:35705 name: immunosuppressive agent namespace: chebi_ontology def: "An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response." [] subset: 3_STAR synonym: "immunosuppressant" RELATED [ChEBI] synonym: "immunosuppressive agents" RELATED [ChEBI] synonym: "inmunosupresor" RELATED [ChEBI] is_a: CHEBI:50846 ! immunomodulator [Term] id: CHEBI:35715 name: nitro compound namespace: chebi_ontology def: "A compound having a nitro group, -NO2 (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, C-nitro compounds are usually implied)." [] subset: 3_STAR synonym: "nitro compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_part CHEBI:29785 ! nitro group [Term] id: CHEBI:35716 name: C-nitro compound namespace: chebi_ontology def: "A nitro compound having the nitro group (-NO2) attached to a carbon atom." [] subset: 3_STAR synonym: "C-nitro compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35715 ! nitro compound is_a: CHEBI:72695 ! organic molecule relationship: is_tautomer_of CHEBI:136622 ! aci-nitro compound [Term] id: CHEBI:35718 name: antifungal agent namespace: chebi_ontology def: "An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce." [] subset: 3_STAR synonym: "antifungal" RELATED [ChEBI] synonym: "antifungal agents" RELATED [ChEBI] synonym: "antifungal drug" RELATED [ChEBI] synonym: "antifungal drugs" RELATED [ChEBI] synonym: "antifungals" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:35720 name: enrofloxacin namespace: chebi_ontology def: "A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets." [] subset: 3_STAR synonym: "1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Baytril" RELATED [ChemIDplus] synonym: "Enrofloxacin" EXACT [ChemIDplus] xref: CAS:93106-60-6 {source="ChemIDplus"} xref: Drug_Central:1017 {source="DrugCentral"} xref: HMDB:HMDB0029861 xref: KEGG:D02473 xref: LINCS:LSM-3709 xref: Patent:KR20130080422 xref: Patent:RU2491922 xref: Patent:US4659603 xref: PMID:15967281 {source="Europe PMC"} xref: PMID:19376344 {source="Europe PMC"} xref: PMID:24380725 {source="Europe PMC"} xref: PMID:26963935 {source="Europe PMC"} xref: PMID:8828132 {source="Europe PMC"} xref: Reaxys:5307824 {source="Reaxys"} xref: VSDB:1762 xref: Wikipedia:Enrofloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46845 ! N-alkylpiperazine is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:51454 ! cyclopropanes relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H22FN3O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SPFYMRJSYKOXGV-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "359.395" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "359.16452" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)F)N4CCN(CC4)CC" xsd:string [Term] id: CHEBI:35727 name: triazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms." [] subset: 3_STAR synonym: "triazole compounds" RELATED [ChEBI] is_a: CHEBI:68452 ! azole [Term] id: CHEBI:35757 name: monocarboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13657 alt_id: CHEBI:25382 alt_id: CHEBI:3407 def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a monocarboxylate" RELATED [UniProt] synonym: "Carboxylate" RELATED [KEGG_COMPOUND] synonym: "Monocarboxylate" RELATED [KEGG_COMPOUND] synonym: "monocarboxylates" RELATED [ChEBI] synonym: "monocarboxylic acid anions" RELATED [ChEBI] xref: KEGG:C00060 is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.01000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string [Term] id: CHEBI:35780 name: phosphate ion namespace: chebi_ontology def: "A phosphorus oxoanion that is the conjugate base of phosphoric acid." [] subset: 3_STAR synonym: "phosphate" RELATED [ChEBI] synonym: "phosphate ions" RELATED [ChEBI] synonym: "Pi" RELATED [ChEBI] is_a: CHEBI:33461 ! phosphorus oxoanion relationship: is_conjugate_base_of CHEBI:26078 ! phosphoric acid relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:35785 name: sphingoid namespace: chebi_ontology def: "Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds." [] subset: 3_STAR synonym: "Spd" RELATED [CBN] synonym: "sphingoid" EXACT [CBN] synonym: "sphingoid base" RELATED [CBN] synonym: "sphingoid bases" RELATED [LIPID_MAPS] synonym: "sphingoids" RELATED [ChEBI] xref: LIPID_MAPS_class:LMSP01 {source="LIPID MAPS"} is_a: CHEBI:26739 ! sphingolipid relationship: is_conjugate_base_of CHEBI:83876 ! cationic sphingoid [Term] id: CHEBI:35790 name: oxazole namespace: chebi_ontology def: "An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom." [] subset: 3_STAR synonym: "oxazole" EXACT [ChEBI] synonym: "oxazoles" RELATED [ChEBI] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:68452 ! azole [Term] id: CHEBI:35816 name: leprostatic drug namespace: chebi_ontology def: "A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions." [] subset: 3_STAR synonym: "leprostatic" RELATED [ChEBI] synonym: "leprostatic agent" RELATED [ChEBI] synonym: "leprostatic drugs" RELATED [ChEBI] is_a: CHEBI:64912 ! antimycobacterial drug [Term] id: CHEBI:35819 name: branched-chain fatty acid namespace: chebi_ontology alt_id: CHEBI:22919 alt_id: CHEBI:3166 def: "Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids." [] subset: 3_STAR synonym: "BCFA" RELATED [ChEBI] synonym: "BCFAs" RELATED [ChEBI] synonym: "Branched chain fatty acid" RELATED [KEGG_COMPOUND] synonym: "branched fatty acid" RELATED [ChEBI] synonym: "branched fatty acids" RELATED [ChEBI] synonym: "branched-chain fatty acids" RELATED [ChEBI] xref: KEGG:C05996 xref: PMID:18318842 {source="Europe PMC"} is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:58955 ! branched-chain fatty acid anion [Term] id: CHEBI:35820 name: antiprotozoal drug namespace: chebi_ontology def: "Any antimicrobial drug which is used to treat or prevent protozoal infections." [] subset: 3_STAR synonym: "antiprotozoal agent" RELATED [ChEBI] synonym: "antiprotozoal agents" RELATED [ChEBI] synonym: "antiprotozoal drugs" RELATED [ChEBI] xref: Wikipedia:Antiprotozoal_agent is_a: CHEBI:35442 ! antiparasitic agent is_a: CHEBI:36043 ! antimicrobial drug [Term] id: CHEBI:35842 name: antirheumatic drug namespace: chebi_ontology def: "A drug used to treat rheumatoid arthritis." [] subset: 3_STAR synonym: "anti-rheumatic drugs" RELATED [ChEBI] synonym: "antirheumatic agent" RELATED [ChEBI] synonym: "antirheumatic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35850 name: sulfone namespace: chebi_ontology def: "An organosulfur compound having the structure RS(=O)2R (R =/= H)." [] subset: 3_STAR synonym: "sulfone" EXACT [ChEBI] synonym: "sulfones" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound [Term] id: CHEBI:35856 name: lipoxygenase inhibitor namespace: chebi_ontology def: "A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes." [] subset: 3_STAR synonym: "lipooxygenase inhibitor" RELATED [ChEBI] synonym: "lipoxygenase inhibitors" RELATED [ChEBI] is_a: CHEBI:76837 ! EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor [Term] id: CHEBI:35862 name: bacitracin A namespace: chebi_ontology def: "A homodetic cyclic peptide consisting of (4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid attached head-to-tail to L-leucyl,D-glutamyl, L-lysyl, D-ornityl, L-isoleucyl, D-phenylalanyl, L-histidyl. D-aspartyl and L-asparaginyl residues coupled in sequence and cyclised by condensation of the side-chain amino group of the L-lysyl residue with the C-terminal carboxylic acid group. It is the major component of bacitracin." [] subset: 3_STAR synonym: "Bacitracin A2a" RELATED [ChemIDplus] synonym: "Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-l-leucine)-" RELATED [ChemIDplus] synonym: "N-({(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-L-leucyl-D-alpha-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]-L-isoleucinamide" EXACT IUPAC_NAME [IUPAC] xref: CAS:22601-59-8 {source="ChemIDplus"} xref: CAS:22601-59-8 {source="KEGG COMPOUND"} xref: KEGG:C15482 xref: Reaxys:8969478 {source="Reaxys"} is_a: CHEBI:15841 ! polypeptide is_a: CHEBI:24613 ! homodetic cyclic peptide relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C66H103N17O16S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CLKOFPXJLQSYAH-ABRJDSQDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1422.69300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1421.74894" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H](C)[C@H](N)C1=N[C@@H](CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC1=O)[C@@H](C)CC" xsd:string [Term] id: CHEBI:35868 name: hydroxy monocarboxylic acid namespace: chebi_ontology def: "Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent." [] subset: 3_STAR synonym: "hydroxy acid" RELATED [ChEBI] synonym: "hydroxy monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:24669 ! hydroxy carboxylic acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:36059 ! hydroxy monocarboxylic acid anion [Term] id: CHEBI:35871 name: oxo monocarboxylic acid namespace: chebi_ontology def: "Any monocarboxylic acid having at least one additional oxo functional group." [] subset: 3_STAR synonym: "oxo monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:25754 ! oxo carboxylic acid relationship: is_conjugate_acid_of CHEBI:35902 ! oxo monocarboxylic acid anion [Term] id: CHEBI:35875 name: imidazopyrimidine namespace: chebi_ontology subset: 3_STAR synonym: "imidazopyrimidines" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:35881 name: pnictogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen hydride" EXACT [ChEBI] synonym: "pnictogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33302 ! pnictogen molecular entity [Term] id: CHEBI:35902 name: oxo monocarboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:35178 alt_id: CHEBI:35901 subset: 3_STAR synonym: "oxo monocarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:35903 ! oxo carboxylic acid anion relationship: is_conjugate_base_of CHEBI:35871 ! oxo monocarboxylic acid [Term] id: CHEBI:35903 name: oxo carboxylic acid anion namespace: chebi_ontology def: "Any carboxylic acid anion containing at least one oxo group." [] subset: 3_STAR synonym: "oxo carboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:25754 ! oxo carboxylic acid [Term] id: CHEBI:35915 name: sterol ester namespace: chebi_ontology alt_id: CHEBI:13220 alt_id: CHEBI:15115 alt_id: CHEBI:26770 alt_id: CHEBI:26772 alt_id: CHEBI:9268 alt_id: CHEBI:9269 def: "A steroid ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of a sterol." [] subset: 3_STAR synonym: "3-hydroxysteroid ester" RELATED [ChEBI] synonym: "3-hydroxysteroid esters" RELATED [ChEBI] synonym: "a sterol ester" RELATED [UniProt] synonym: "Sterol ester" EXACT [KEGG_COMPOUND] synonym: "Steryl ester" RELATED [KEGG_COMPOUND] xref: KEGG:C01958 is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:47880 ! steroid ester property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H30O2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "302.452" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "302.22458" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCC(C4)OC(*)=O)C" xsd:string [Term] id: CHEBI:35942 name: neurotransmitter agent namespace: chebi_ontology def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." [] subset: 3_STAR synonym: "neurotransmitter agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:35973 name: 3-oxo monocarboxylic acid anion namespace: chebi_ontology def: "An oxo monocarboxylic acid anion having the oxo group located at the 3-position (R = H or organyl group)." [] subset: 3_STAR synonym: "3-oxo monocarboxylic acid anions" RELATED [ChEBI] synonym: "a 3-oxo acid" RELATED [UniProt] is_a: CHEBI:35902 ! oxo monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:47881 ! 3-oxo monocarboxylic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H2O3R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "86.046" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "86.00039" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C([O-])=O)C(*)=O" xsd:string [Term] id: CHEBI:35983 name: 7-oxo monocarboxylic acid namespace: chebi_ontology subset: 3_STAR synonym: "7-oxo monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:35871 ! oxo monocarboxylic acid [Term] id: CHEBI:35992 name: penams namespace: chebi_ontology def: "Natural and synthetic antibiotics containing the 4-thia-1-azabicyclo[3.2.0]heptan-7-one structure, generally assumed to have the 5R configuration unless otherwise specified." [] subset: 3_STAR synonym: "penams" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:27933 ! beta-lactam antibiotic is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:36027 name: stilbenol namespace: chebi_ontology def: "Any stilbenoid with at least one phenolic group." [] subset: 3_STAR synonym: "stilbenol" EXACT [ChEBI] is_a: CHEBI:26776 ! stilbenoid is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:36043 name: antimicrobial drug namespace: chebi_ontology def: "A drug used to treat or prevent microbial infections." [] subset: 3_STAR synonym: "antimicrobial drugs" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent is_a: CHEBI:35441 ! antiinfective agent [Term] id: CHEBI:36047 name: antibacterial drug namespace: chebi_ontology def: "A drug used to treat or prevent bacterial infections." [] subset: 3_STAR synonym: "antibacterial drugs" RELATED [ChEBI] xref: Wikipedia:Antibacterial is_a: CHEBI:33282 ! antibacterial agent is_a: CHEBI:36043 ! antimicrobial drug [Term] id: CHEBI:36059 name: hydroxy monocarboxylic acid anion namespace: chebi_ontology def: "Any monocarboxylic acid anion carrying at least one hydroxy substituent." [] subset: 3_STAR synonym: "hydroxy monocarboxylic acid anions" RELATED [ChEBI] synonym: "hydroxymonocarboxylic acid anion" RELATED [ChEBI] synonym: "hydroxymonocarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:35868 ! hydroxy monocarboxylic acid [Term] id: CHEBI:36080 name: protein namespace: chebi_ontology alt_id: CHEBI:13677 alt_id: CHEBI:14911 def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." [] subset: 3_STAR synonym: "proteins" EXACT IUPAC_NAME [IUPAC] is_a: PR:000000001 ! protein equivalent_to: PR:000000001 ! protein [Term] id: CHEBI:36093 name: inorganic chloride namespace: chebi_ontology subset: 3_STAR synonym: "inorganic chloride salt" RELATED [ChEBI] synonym: "inorganic chloride salts" RELATED [ChEBI] synonym: "inorganic chlorides" RELATED [ChEBI] is_a: CHEBI:23114 ! chloride salt is_a: CHEBI:24839 ! inorganic salt [Term] id: CHEBI:36141 name: quinone namespace: chebi_ontology alt_id: CHEBI:13684 alt_id: CHEBI:26517 def: "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included)." [] subset: 3_STAR synonym: "Chinon" RELATED [ChEBI] synonym: "quinone" EXACT [IUPAC] synonym: "quinones" EXACT IUPAC_NAME [IUPAC] synonym: "quinones" RELATED [ChEBI] xref: Wikipedia:Quinone is_a: CHEBI:3992 ! cyclic ketone [Term] id: CHEBI:36233 name: disaccharide namespace: chebi_ontology alt_id: CHEBI:23844 alt_id: CHEBI:4654 def: "A compound in which two monosaccharides are joined by a glycosidic bond." [] subset: 3_STAR synonym: "disacarido" RELATED [ChEBI] synonym: "disacaridos" RELATED [IUPAC] synonym: "Disaccharid" RELATED [ChEBI] synonym: "Disaccharide" EXACT [KEGG_COMPOUND] synonym: "disaccharides" EXACT IUPAC_NAME [IUPAC] synonym: "Disacharid" RELATED [ChEBI] xref: KEGG:C01911 is_a: CHEBI:50699 ! oligosaccharide [Term] id: CHEBI:36244 name: dicarboxylic acid monoester namespace: chebi_ontology def: "A monoester of a dicarboxylic acid." [] subset: 3_STAR synonym: "dicarboxylic acid monoesters" RELATED [ChEBI] is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:131605 ! dicarboxylic acid monoester(1-) [Term] id: CHEBI:36335 name: trypanocidal drug namespace: chebi_ontology def: "A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida." [] subset: 3_STAR synonym: "antitrypanosomal agent" RELATED [ChEBI] synonym: "antitrypanosomal agents" RELATED [ChEBI] synonym: "antitrypanosomal drug" RELATED [ChEBI] synonym: "antitrypanosomal drugs" RELATED [ChEBI] synonym: "trypanocidal drugs" RELATED [ChEBI] synonym: "trypanocide" RELATED [ChEBI] synonym: "trypanosomicidal agents" RELATED [ChEBI] is_a: CHEBI:35820 ! antiprotozoal drug [Term] id: CHEBI:36336 name: naphthalenesulfonic acid namespace: chebi_ontology subset: 3_STAR synonym: "naphthalenesulfonic acids" RELATED [ChEBI] is_a: CHEBI:25477 ! naphthalenes is_a: CHEBI:33555 ! arenesulfonic acid [Term] id: CHEBI:36338 name: lepton namespace: chebi_ontology def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." [] subset: 3_STAR synonym: "leptons" RELATED [ChEBI] is_a: CHEBI:33233 ! fundamental particle is_a: CHEBI:36340 ! fermion [Term] id: CHEBI:36339 name: baryon namespace: chebi_ontology def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." [] subset: 3_STAR synonym: "baryons" RELATED [ChEBI] is_a: CHEBI:36340 ! fermion is_a: CHEBI:36344 ! hadron [Term] id: CHEBI:36340 name: fermion namespace: chebi_ontology def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." [] subset: 3_STAR synonym: "fermion" EXACT IUPAC_NAME [IUPAC] synonym: "fermions" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36342 name: subatomic particle namespace: chebi_ontology def: "A particle smaller than an atom." [] subset: 3_STAR synonym: "subatomic particles" RELATED [ChEBI] xref: Wikipedia:Subatomic_particle [Term] id: CHEBI:36343 name: composite particle namespace: chebi_ontology def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." [] subset: 3_STAR synonym: "composite particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36344 name: hadron namespace: chebi_ontology def: "Hadron is a subatomic particle which experiences the strong force." [] subset: 3_STAR synonym: "hadrons" RELATED [ChEBI] is_a: CHEBI:36343 ! composite particle [Term] id: CHEBI:36347 name: nuclear particle namespace: chebi_ontology def: "A nucleus or any of its constituents in any of their energy states." [] subset: 3_STAR synonym: "nuclear particle" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36357 name: polyatomic entity namespace: chebi_ontology def: "Any molecular entity consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:24433 ! group [Term] id: CHEBI:36358 name: polyatomic ion namespace: chebi_ontology def: "An ion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:36359 name: phosphorus oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "phosphorus oxoacid derivative" EXACT [ChEBI] is_a: CHEBI:33241 ! oxoacid derivative is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives relationship: has_functional_parent CHEBI:33457 ! phosphorus oxoacid [Term] id: CHEBI:36360 name: phosphorus oxoacids and derivatives namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26082 ! phosphorus molecular entity [Term] id: CHEBI:36361 name: phosphorous acid namespace: chebi_ontology alt_id: CHEBI:26081 alt_id: CHEBI:29196 subset: 3_STAR synonym: "[P(OH)3]" RELATED [IUPAC] synonym: "H3PO3" RELATED [NIST_Chemistry_WebBook] synonym: "H3PO3" RELATED [IUPAC] synonym: "P(OH)3" RELATED [IUPAC] synonym: "phosphite" RELATED [UniProt] synonym: "phosphorige Saeure" RELATED [ChEBI] synonym: "phosphorous acid" EXACT [IUPAC] synonym: "trihydrogen trioxophosphate(3-)" EXACT IUPAC_NAME [IUPAC] synonym: "trihydroxidophosphorus" EXACT IUPAC_NAME [IUPAC] synonym: "trioxophosphoric(3-) acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:10294-56-1 {source="ChemIDplus"} xref: CAS:10294-56-1 {source="NIST Chemistry WebBook"} xref: Gmelin:164068 {source="Gmelin"} is_a: CHEBI:33457 ! phosphorus oxoacid relationship: is_conjugate_acid_of CHEBI:29258 ! dihydrogenphosphite relationship: is_tautomer_of CHEBI:44976 ! phosphonic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H3O3P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O3P/c1-4(2)3/h1-3H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OJMIONKXNSYLSR-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "81.99578" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.98198" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP(O[H])O[H]" xsd:string [Term] id: CHEBI:36386 name: dichloroacetic acid namespace: chebi_ontology alt_id: CHEBI:23695 alt_id: CHEBI:4502 alt_id: CHEBI:49918 def: "An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis." [] subset: 3_STAR synonym: "2,2-dichloroacetic acid" RELATED [ChemIDplus] synonym: "bichloracetic acid" RELATED [NIST_Chemistry_WebBook] synonym: "dichloracetic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Dichloressigsaeure" RELATED [ChEBI] synonym: "DICHLORO-ACETIC ACID" RELATED [PDBeChem] synonym: "Dichloroacetate" RELATED [KEGG_COMPOUND] synonym: "dichloroacetic acid" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:1098596 {source="ChemIDplus"} xref: CAS:79-43-6 {source="NIST Chemistry WebBook"} xref: CAS:79-43-6 {source="ChemIDplus"} xref: CAS:79-43-6 {source="KEGG COMPOUND"} xref: Drug_Central:862 {source="DrugCentral"} xref: DrugBank:DB08809 xref: Gmelin:2477 {source="Gmelin"} xref: KEGG:C11149 xref: LINCS:LSM-5314 xref: MetaCyc:CPD-9674 xref: PDBeChem:TF4 xref: PMID:24112699 {source="Europe PMC"} xref: Reaxys:1098596 {source="Reaxys"} xref: Wikipedia:Dichloroacetic_acid is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:36683 ! organochlorine compound relationship: has_functional_parent CHEBI:15366 ! acetic acid relationship: is_conjugate_acid_of CHEBI:28240 ! dichloroacetate relationship: RO:0000087 CHEBI:74783 ! has role astringent relationship: RO:0000087 CHEBI:76507 ! has role marine metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H2Cl2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JXTHNDFMNIQAHM-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "128.94148" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "127.94318" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)C(Cl)Cl" xsd:string [Term] id: CHEBI:36388 name: saturated organic heterocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "saturated heterocyclic parent hydride" RELATED [ChEBI] synonym: "saturated heterocyclic parent hydrides" RELATED [ChEBI] synonym: "saturated organic heterocyclic parents" RELATED [ChEBI] is_a: CHEBI:35552 ! heterocyclic organic fundamental parent [Term] id: CHEBI:36389 name: saturated organic heteromonocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "saturated heteromonocyclic parent hydride" RELATED [ChEBI] synonym: "saturated heteromonocyclic parent hydrides" RELATED [ChEBI] synonym: "saturated organic heteromonocyclic parents" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:36388 ! saturated organic heterocyclic parent [Term] id: CHEBI:3639 name: chlorothalonil namespace: chebi_ontology def: "A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops." [] subset: 3_STAR synonym: "1,3-Dicyanotetrachlorobenzene" RELATED [ChemIDplus] synonym: "2,4,5,6-Tetrachloro-3-cyanobenzonitrile" RELATED [ChemIDplus] synonym: "2,4,5,6-tetrachlorobenzene-1,3-dicarbonitrile" EXACT IUPAC_NAME [IUPAC] synonym: "Chlorothalonil" EXACT [KEGG_COMPOUND] synonym: "chlorothalonil" EXACT [UniProt] synonym: "Daconil" RELATED BRAND_NAME [KEGG_COMPOUND] synonym: "m-TCPN" RELATED [ChemIDplus] synonym: "m-Tetrachlorophthalonitrile" RELATED [ChemIDplus] synonym: "meta-TCPN" RELATED [ChemIDplus] synonym: "meta-Tetrachlorophthalodinitrile" RELATED [ChemIDplus] synonym: "Tetrachloroisophthalonitrile" RELATED [KEGG_COMPOUND] synonym: "TPN" RELATED [KEGG_COMPOUND] xref: Beilstein:1978326 {source="Beilstein"} xref: CAS:1897-45-6 {source="NIST Chemistry WebBook"} xref: CAS:1897-45-6 {source="KEGG COMPOUND"} xref: KEGG:C11037 xref: Patent:US3290353 xref: Patent:US3652637 xref: Pesticides:chlorothalonil {source="Alan Wood's Pesticides"} xref: PMID:11016668 {source="Europe PMC"} xref: PMID:14575671 {source="Europe PMC"} xref: PMID:17482661 {source="Europe PMC"} xref: PMID:23116300 {source="Europe PMC"} xref: PMID:23866729 {source="Europe PMC"} xref: PMID:24455968 {source="Europe PMC"} xref: PMID:24984836 {source="Europe PMC"} xref: PMID:24990551 {source="Europe PMC"} xref: PPDB:150 xref: Reaxys:1978326 {source="Reaxys"} xref: Wikipedia:Chlorothalonil is_a: CHEBI:26888 ! tetrachlorobenzene is_a: CHEBI:51308 ! dinitrile is_a: CHEBI:87034 ! aromatic fungicide relationship: has_functional_parent CHEBI:38218 ! isophthalonitrile relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8Cl4N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8Cl4N2/c9-5-3(1-13)6(10)8(12)7(11)4(5)2-14" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CRQQGFGUEAVUIL-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "265.90988" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "263.88156" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Clc1c(Cl)c(C#N)c(Cl)c(C#N)c1Cl" xsd:string [Term] id: CHEBI:36563 name: zinc group coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc group coordination compounds" RELATED [ChEBI] synonym: "zinc group coordination entities" RELATED [ChEBI] is_a: CHEBI:33240 ! coordination entity is_a: CHEBI:33673 ! zinc group molecular entity [Term] id: CHEBI:36566 name: zinc coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc coordination compounds" RELATED [ChEBI] synonym: "zinc coordination entities" RELATED [ChEBI] is_a: CHEBI:27364 ! zinc molecular entity is_a: CHEBI:36563 ! zinc group coordination entity [Term] id: CHEBI:36586 name: carbonyl compound namespace: chebi_ontology def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." [] subset: 3_STAR synonym: "carbonyl compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36587 ! organic oxo compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23019 ! carbonyl group [Term] id: CHEBI:36587 name: organic oxo compound namespace: chebi_ontology def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." [] subset: 3_STAR synonym: "organic oxo compounds" RELATED [ChEBI] synonym: "oxo compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:72695 ! organic molecule relationship: has_part CHEBI:46629 ! oxo group [Term] id: CHEBI:36622 name: benzimidazole namespace: chebi_ontology def: "A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings." [] subset: 3_STAR synonym: "Benzimidazol" RELATED [ChEBI] synonym: "benzimidazole" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Benzimidazole is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:35570 ! mancude organic heterobicyclic parent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "118.136" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "118.05310" xsd:string [Term] id: CHEBI:36623 name: 4H-benzimidazole namespace: chebi_ontology subset: 3_STAR synonym: "4H-benzimidazole" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36622 ! benzimidazole relationship: is_tautomer_of CHEBI:36639 ! 2H-benzimidazole relationship: is_tautomer_of CHEBI:36641 ! 3aH-benzimidazole relationship: is_tautomer_of CHEBI:41275 ! 1H-benzimidazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-3,5H,4H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VSTRESXSGAUGKC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "118.13602" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "118.05310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1C=CC=C2N=CN=C12" xsd:string [Term] id: CHEBI:36624 name: naphthyridine namespace: chebi_ontology def: "Any one of eight organic heterobicyclic compounds that have a naphthalene skeleton in which two of the carbons are replaced by nitrogens. A 'closed' class." [] subset: 3_STAR synonym: "naphthyridine" EXACT IUPAC_NAME [IUPAC] xref: Wikipedia:Naphthyridine is_a: CHEBI:35570 ! mancude organic heterobicyclic parent is_a: CHEBI:50893 ! azaarene is_a: CHEBI:52362 ! ortho-fused heteroarene property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "130.147" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "130.05310" xsd:string [Term] id: CHEBI:36628 name: 1,8-naphthyridine namespace: chebi_ontology def: "A naphthyridine in which the nitrogens are situated at positions 1 and 8." [] subset: 3_STAR synonym: "1,8-diazanaphthalene" RELATED [NIST_Chemistry_WebBook] synonym: "1,8-naphthyridine" EXACT IUPAC_NAME [IUPAC] synonym: "1,8-pyridopyridine" RELATED [NIST_Chemistry_WebBook] synonym: "napy" RELATED [IUPAC] xref: Beilstein:109347 {source="Beilstein"} xref: CAS:254-60-4 {source="NIST Chemistry WebBook"} xref: CAS:254-60-4 {source="ChemIDplus"} xref: Gmelin:27124 {source="Gmelin"} xref: Reaxys:109347 {source="Reaxys"} is_a: CHEBI:36624 ! naphthyridine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H6N2/c1-3-7-4-2-6-10-8(7)9-5-1/h1-6H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FLBAYUMRQUHISI-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "130.14660" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "130.05310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1cnc2ncccc2c1" xsd:string [Term] id: CHEBI:36639 name: 2H-benzimidazole namespace: chebi_ontology subset: 3_STAR synonym: "2H-benzimidazole" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36622 ! benzimidazole relationship: is_tautomer_of CHEBI:36623 ! 4H-benzimidazole relationship: is_tautomer_of CHEBI:36641 ! 3aH-benzimidazole relationship: is_tautomer_of CHEBI:41275 ! 1H-benzimidazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-4H,5H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NLMVLMCSXDIGSW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "118.13602" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "118.05310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1N=c2ccccc2=N1" xsd:string [Term] id: CHEBI:36641 name: 3aH-benzimidazole namespace: chebi_ontology subset: 3_STAR synonym: "3aH-benzimidazole" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:36622 ! benzimidazole relationship: is_tautomer_of CHEBI:36623 ! 4H-benzimidazole relationship: is_tautomer_of CHEBI:36639 ! 2H-benzimidazole relationship: is_tautomer_of CHEBI:41275 ! 1H-benzimidazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-6H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VRKAZVNMMPXRKG-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "118.13602" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "118.05310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC2N=CN=C2C=C1" xsd:string [Term] id: CHEBI:36683 name: organochlorine compound namespace: chebi_ontology def: "An organochlorine compound is a compound containing at least one carbon-chlorine bond." [] subset: 3_STAR synonym: "an organochlorine molecule" RELATED [UniProt] synonym: "chloroorganic compounds" RELATED [ChEBI] synonym: "chlororganische Verbindungen" RELATED [ChEBI] synonym: "organochloride" RELATED [ChEBI] synonym: "organochloride compound" RELATED [ChEBI] synonym: "organochloride compounds" RELATED [ChEBI] synonym: "organochlorides" RELATED [ChEBI] synonym: "organochlorine compound" EXACT [ChEBI] synonym: "organochlorine compounds" RELATED [ChEBI] xref: MetaCyc:Chlorides xref: Wikipedia:Organochloride is_a: CHEBI:17792 ! organohalogen compound is_a: CHEBI:23117 ! chlorine molecular entity property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "ClR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "35.453" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96885" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*Cl" xsd:string [Term] id: CHEBI:36688 name: heterotricyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterotricyclic compound" EXACT [ChEBI] synonym: "heterotricyclic compounds" EXACT IUPAC_NAME [IUPAC] synonym: "heterotricyclic compounds" RELATED [ChEBI] is_a: CHEBI:33671 ! heteropolycyclic compound [Term] id: CHEBI:36700 name: phosphocholines namespace: chebi_ontology def: "Any compound having phosphocholine as part of its structure." [] subset: 3_STAR synonym: "choline phosphates" RELATED [ChEBI] synonym: "O-phosphocholines" RELATED [ChEBI] synonym: "phosphorylcholines" RELATED [ChEBI] is_a: CHEBI:23213 ! choline ester is_a: CHEBI:23217 ! cholines is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester [Term] id: CHEBI:36709 name: aminoquinoline namespace: chebi_ontology def: "Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups." [] subset: 3_STAR synonym: "aminoquinoline" EXACT [ChEBI] synonym: "aminoquinolines" RELATED [ChEBI] is_a: CHEBI:26513 ! quinolines is_a: CHEBI:33860 ! aromatic amine [Term] id: CHEBI:36756 name: farnesane namespace: chebi_ontology def: "A sesquiterpene that is dodecane substituted by methyl groups at positions 2, 6 and 10." [] subset: 3_STAR synonym: "2,6,10-trimethyldodecane" EXACT IUPAC_NAME [IUPAC] synonym: "Farnesan" RELATED [NIST_Chemistry_WebBook] synonym: "farnesane" EXACT [NIST_Chemistry_WebBook] xref: Beilstein:1719672 {source="Beilstein"} xref: CAS:3891-98-3 {source="NIST Chemistry WebBook"} xref: CAS:3891-98-3 {source="ChemIDplus"} xref: LIPID_MAPS_instance:LMPR0103010000 {source="LIPID MAPS"} xref: MetaCyc:CPD-8764 xref: Patent:US2008098645 xref: Patent:US7399323 xref: Reaxys:1719672 {source="Reaxys"} is_a: CHEBI:18310 ! alkane is_a: CHEBI:35189 ! sesquiterpene relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H32" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H32/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h13-15H,6-12H2,1-5H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YFHFHLSMISYUAQ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "212.41458" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "212.25040" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC(C)CCCC(C)CCCC(C)C" xsd:string [Term] id: CHEBI:36757 name: farnesane sesquiterpenoid namespace: chebi_ontology subset: 3_STAR synonym: "farnesane sesquiterpenoid" EXACT [ChEBI] synonym: "farnesane sesquiterpenoids" RELATED [ChEBI] is_a: CHEBI:26658 ! sesquiterpenoid relationship: has_parent_hydride CHEBI:36756 ! farnesane [Term] id: CHEBI:36785 name: carbobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which all the ring atoms are carbon." [] subset: 3_STAR synonym: "carbobicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:35294 ! carbopolycyclic compound [Term] id: CHEBI:36816 name: oxime O-ether namespace: chebi_ontology def: "O-organyl oximes R2C=NOR' (R' =/= H)." [] subset: 3_STAR synonym: "O-substituted oximes" RELATED [ChEBI] synonym: "oxime ether" RELATED [ChEBI] synonym: "oxime ethers" RELATED [ChEBI] synonym: "oxime O-ether" EXACT [IUPAC] synonym: "oxime O-ethers" EXACT IUPAC_NAME [IUPAC] synonym: "oxime O-ethers" RELATED [ChEBI] is_a: CHEBI:25698 ! ether is_a: CHEBI:35352 ! organonitrogen compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "42.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]O\\N=C(/[*])[*]" xsd:string [Term] id: CHEBI:36820 name: ring assembly namespace: chebi_ontology def: "Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved." [] subset: 3_STAR synonym: "ring assemblies" EXACT IUPAC_NAME [IUPAC] synonym: "ring assembly" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:36823 name: pseudohalo group namespace: chebi_ontology subset: 3_STAR synonym: "halogenoid group" RELATED [ChEBI] synonym: "pseudohalide group" EXACT IUPAC_NAME [IUPAC] synonym: "pseudohalido group" RELATED [ChEBI] synonym: "pseudohalo groups" RELATED [ChEBI] synonym: "pseudohalogen group" RELATED [IUPAC] is_a: CHEBI:24433 ! group [Term] id: CHEBI:36828 name: pseudohalide anion namespace: chebi_ontology subset: 3_STAR synonym: "pseudohalide anions" RELATED [ChEBI] synonym: "pseudohalide ions" EXACT IUPAC_NAME [IUPAC] synonym: "pseudohalides" RELATED [ChEBI] synonym: "pseudohalogen anion" RELATED [ChEBI] synonym: "pseudohalogen ion" RELATED [ChEBI] is_a: CHEBI:36829 ! polyatomic monoanion [Term] id: CHEBI:36829 name: polyatomic monoanion namespace: chebi_ontology subset: 3_STAR synonym: "polyatomic monoanions" RELATED [ChEBI] is_a: CHEBI:33273 ! polyatomic anion is_a: CHEBI:36830 ! monoanion [Term] id: CHEBI:36830 name: monoanion namespace: chebi_ontology subset: 3_STAR synonym: "monoanions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string [Term] id: CHEBI:36834 name: 3-hydroxy steroid namespace: chebi_ontology def: "Any hydroxy steroid carrying a hydroxy group at position 3." [] subset: 3_STAR synonym: "3-hydroxy steroids" RELATED [ChEBI] is_a: CHEBI:35350 ! hydroxy steroid [Term] id: CHEBI:36835 name: 3alpha-hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:71194 def: "A 3-hydroxy steroid in which the 3-hydroxy substituent is in the alpha-position." [] subset: 3_STAR synonym: "3alpha-hydroxy steroids" RELATED [ChEBI] synonym: "3alpha-hydroxysteroid" RELATED [ChEBI] synonym: "3alpha-hydroxysteroids" RELATED [ChEBI] synonym: "a 3alpha-hydroxysteroid" RELATED [UniProt] xref: MetaCyc:3-alpha-Hydroxysteroids xref: PMID:11514561 {source="SUBMITTER"} is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:36834 ! 3-hydroxy steroid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31OR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "275.450" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "275.23749" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CC[C@H](C4)O)C" xsd:string [Term] id: CHEBI:36841 name: 11-hydroxy steroid namespace: chebi_ontology subset: 3_STAR synonym: "11-hydroxy steroids" RELATED [ChEBI] is_a: CHEBI:35350 ! hydroxy steroid [Term] id: CHEBI:36856 name: hydrogen isocyanide namespace: chebi_ontology subset: 3_STAR synonym: "CNH" RELATED [ChEBI] synonym: "HN(+)#C(-)" RELATED [IUPAC] synonym: "HNC" RELATED [NIST_Chemistry_WebBook] synonym: "hydrogen isocyanide" EXACT [NIST_Chemistry_WebBook] synonym: "hydroisocyanic acid" RELATED [ChEBI] synonym: "nitriliomethanide" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:2069401 {source="Beilstein"} xref: CAS:6914-07-4 {source="NIST Chemistry WebBook"} xref: Gmelin:113 {source="Gmelin"} is_a: CHEBI:33405 ! hydracid relationship: is_conjugate_acid_of CHEBI:17514 ! cyanide relationship: is_tautomer_of CHEBI:18407 ! hydrogen cyanide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHN" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CHN/c1-2/h2H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QIUBLANJVAOHHY-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "27.02538" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.01090" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C-]#[NH+]" xsd:string [Term] id: CHEBI:36902 name: chalcogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen hydride" EXACT [ChEBI] synonym: "chalcogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36914 name: inorganic ion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic ions" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36915 name: inorganic cation namespace: chebi_ontology subset: 3_STAR synonym: "inorganic cations" RELATED [ChEBI] is_a: CHEBI:36914 ! inorganic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:36916 name: cation namespace: chebi_ontology alt_id: CHEBI:23058 alt_id: CHEBI:3473 def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." [] subset: 3_STAR synonym: "Cation" EXACT [KEGG_COMPOUND] synonym: "cation" EXACT IUPAC_NAME [IUPAC] synonym: "cation" EXACT [ChEBI] synonym: "cationes" RELATED [ChEBI] synonym: "cations" RELATED [ChEBI] synonym: "Kation" RELATED [ChEBI] synonym: "Kationen" RELATED [ChEBI] xref: KEGG:C01373 is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36961 name: chalcocarbonic acid namespace: chebi_ontology subset: 3_STAR synonym: "chalcocarbonic acid" EXACT [ChEBI] synonym: "chalcocarbonic acids" EXACT IUPAC_NAME [IUPAC] synonym: "chalcocarbonic acids" RELATED [ChEBI] is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:36962 name: organochalcogen compound namespace: chebi_ontology def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." [] subset: 3_STAR synonym: "organochalcogen compound" EXACT [ChEBI] synonym: "organochalcogen compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36963 name: organooxygen compound namespace: chebi_ontology def: "An organochalcogen compound containing at least one carbon-oxygen bond." [] subset: 3_STAR synonym: "organooxygen compound" EXACT [ChEBI] synonym: "organooxygen compounds" RELATED [ChEBI] xref: PMID:17586126 {source="Europe PMC"} is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:36976 name: nucleotide namespace: chebi_ontology alt_id: CHEBI:13215 alt_id: CHEBI:13663 alt_id: CHEBI:7656 def: "A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid." [] subset: 3_STAR synonym: "Nucleotide" EXACT [KEGG_COMPOUND] synonym: "nucleotides" RELATED [ChEBI] xref: KEGG:C00215 xref: Wikipedia:Nucleotide is_a: CHEBI:25608 ! nucleoside phosphate [Term] id: CHEBI:36982 name: cyclic purine nucleotide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic purine nucleotides" RELATED [ChEBI] is_a: CHEBI:23447 ! cyclic nucleotide is_a: CHEBI:26395 ! purine nucleotide [Term] id: CHEBI:36988 name: 5'-deoxyribonucleoside namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:23636 ! deoxyribonucleoside [Term] id: CHEBI:37022 name: amino-acid anion namespace: chebi_ontology subset: 3_STAR synonym: "amino acid anions" RELATED [ChEBI] synonym: "amino-acid anion" EXACT [ChEBI] synonym: "amino-acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion is_a: CHEBI:35352 ! organonitrogen compound relationship: is_conjugate_base_of CHEBI:33709 ! amino acid [Term] id: CHEBI:37142 name: organoiodine compound namespace: chebi_ontology def: "An organoiodine compound is a compound containing at least one carbon-iodine bond." [] subset: 3_STAR synonym: "organoiodine compound" EXACT [ChEBI] synonym: "organoiodine compounds" RELATED [ChEBI] xref: MetaCyc:Organoiodine-Compounds xref: Wikipedia:Organoiodine_compound is_a: CHEBI:17792 ! organohalogen compound is_a: CHEBI:24860 ! iodine molecular entity property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "IR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "126.904" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "126.90447" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*I" xsd:string [Term] id: CHEBI:37143 name: organofluorine compound namespace: chebi_ontology def: "An organofluorine compound is a compound containing at least one carbon-fluorine bond." [] subset: 3_STAR synonym: "fluoroorganic compound" RELATED [ChEBI] synonym: "fluoroorganic compounds" RELATED [ChEBI] synonym: "fluoroorganics" RELATED [ChEBI] synonym: "fluororganische Verbindungen" RELATED [ChEBI] synonym: "organofluorine compound" EXACT [ChEBI] synonym: "organofluorine compounds" RELATED [ChEBI] xref: MetaCyc:Fluorides is_a: CHEBI:17792 ! organohalogen compound is_a: CHEBI:24062 ! fluorine molecular entity property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "FR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "18.998" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*F" xsd:string [Term] id: CHEBI:37153 name: EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor namespace: chebi_ontology alt_id: CHEBI:62670 def: "Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16)." [] subset: 3_STAR synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor" RELATED [ChEBI] synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors" RELATED [ChEBI] synonym: "Aspergillus awamori acid protein phosphatase inhibitor" RELATED [ChEBI] synonym: "Aspergillus awamori acid protein phosphatase inhibitors" RELATED [ChEBI] synonym: "BCKDH phosphatase inhibitor" RELATED [ChEBI] synonym: "BCKDH phosphatase inhibitors" RELATED [ChEBI] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor" RELATED [ChEBI] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors" RELATED [ChEBI] synonym: "calcineurin inhibitor" RELATED [ChEBI] synonym: "calcineurin inhibitors" RELATED [ChEBI] synonym: "casein phosphatase inhibitor" RELATED [ChEBI] synonym: "casein phosphatase inhibitors" RELATED [ChEBI] synonym: "EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.3.16 inhibitor" RELATED [ChEBI] synonym: "EC 3.1.3.16 inhibitors" RELATED [ChEBI] synonym: "HMG-CoA reductase phosphatase inhibitor" RELATED [ChEBI] synonym: "HMG-CoA reductase phosphatase inhibitors" RELATED [ChEBI] synonym: "phosphatase 2A inhibitor" RELATED [ChEBI] synonym: "phosphatase 2A inhibitors" RELATED [ChEBI] synonym: "phosphatase 2B inhibitor" RELATED [ChEBI] synonym: "phosphatase 2B inhibitors" RELATED [ChEBI] synonym: "phosphatase C-II inhibitor" RELATED [ChEBI] synonym: "phosphatase C-II inhibitors" RELATED [ChEBI] synonym: "phosphatase H-II inhibitor" RELATED [ChEBI] synonym: "phosphatase H-II inhibitors" RELATED [ChEBI] synonym: "phosphatase I inhibitor" RELATED [ChEBI] synonym: "phosphatase I inhibitors" RELATED [ChEBI] synonym: "phosphatase IB inhibitor" RELATED [ChEBI] synonym: "phosphatase IB inhibitors" RELATED [ChEBI] synonym: "phosphatase II inhibitor" RELATED [ChEBI] synonym: "phosphatase II inhibitors" RELATED [ChEBI] synonym: "phosphatase III inhibitor" RELATED [ChEBI] synonym: "phosphatase III inhibitors" RELATED [ChEBI] synonym: "phosphatase IV inhibitor" RELATED [ChEBI] synonym: "phosphatase IV inhibitors" RELATED [ChEBI] synonym: "phosphatase SP inhibitor" RELATED [ChEBI] synonym: "phosphatase SP inhibitors" RELATED [ChEBI] synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitor" RELATED [ChEBI] synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitors" RELATED [ChEBI] synonym: "phosphoprotein phosphatase inhibitor" RELATED [ChEBI] synonym: "phosphoprotein phosphatase inhibitors" RELATED [ChEBI] synonym: "phosphoprotein phosphohydrolase inhibitor" RELATED [ChEBI] synonym: "phosphoprotein phosphohydrolase inhibitors" RELATED [ChEBI] synonym: "phosphopyruvate dehydrogenase phosphatase inhibitor" RELATED [ChEBI] synonym: "phosphopyruvate dehydrogenase phosphatase inhibitors" RELATED [ChEBI] synonym: "phosphospectrin phosphatase inhibitor" RELATED [ChEBI] synonym: "phosphospectrin phosphatase inhibitors" RELATED [ChEBI] synonym: "polycation modulated (PCM-) phosphatase inhibitor" RELATED [ChEBI] synonym: "polycation modulated (PCM-) phosphatase inhibitors" RELATED [ChEBI] synonym: "protein D phosphatase inhibitor" RELATED [ChEBI] synonym: "protein D phosphatase inhibitors" RELATED [ChEBI] synonym: "protein phosphatase inhibitor" RELATED [ChEBI] synonym: "protein phosphatase inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-1 inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-1 inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-2A inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-2A inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-2B inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-2B inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-2C inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-2C inhibitors" RELATED [ChEBI] synonym: "protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors" RELATED [ChEBI] synonym: "protein serine/threonine phosphatase inhibitor" RELATED [ChEBI] synonym: "protein serine/threonine phosphatase inhibitors" RELATED [ChEBI] synonym: "serine/threonine specific protein phosphatase inhibitor" RELATED [ChEBI] synonym: "serine/threonine specific protein phosphatase inhibitors" RELATED [ChEBI] xref: Wikipedia:Phosphoprotein_phosphatase xref: Wikipedia:Protein_serine/threonine_phosphatase is_a: CHEBI:76775 ! EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor [Term] id: CHEBI:37175 name: organic hydride namespace: chebi_ontology subset: 3_STAR synonym: "organic hydrides" RELATED [ChEBI] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37176 name: mononuclear parent hydride namespace: chebi_ontology subset: 3_STAR synonym: "mononuclear hydride" RELATED [ChEBI] synonym: "mononuclear hydrides" RELATED [IUPAC] synonym: "mononuclear parent hydrides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37206 name: hexol namespace: chebi_ontology def: "A polyol that contains 6 hydroxy groups." [] subset: 3_STAR synonym: "hexol" EXACT IUPAC_NAME [IUPAC] synonym: "hexols" RELATED [ChEBI] is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:37246 name: elemental sodium namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26712 ! sodium molecular entity [Term] id: CHEBI:37247 name: elemental potassium namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26217 ! potassium molecular entity [Term] id: CHEBI:3732 name: clarithromycin namespace: chebi_ontology alt_id: CHEBI:41676 alt_id: CHEBI:442148 alt_id: CHEBI:670147 def: "The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis." [] subset: 3_STAR synonym: "6-O-methylerythromycin" RELATED [ChemIDplus] synonym: "6-O-methylerythromycin A" RELATED [ChemIDplus] synonym: "CLA" RELATED [DrugBank] synonym: "CLARITHROMYCIN" EXACT [PDBeChem] synonym: "Clarithromycin" EXACT [KEGG_COMPOUND] synonym: "clarithromycin" RELATED INN [ChemIDplus] synonym: "clarithromycina" RELATED INN [ChemIDplus] synonym: "clarithromycine" RELATED INN [ChemIDplus] synonym: "clarithromycinum" RELATED INN [ChemIDplus] synonym: "O(6)-methylerythromycin" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3581974 {source="Beilstein"} xref: CAS:81103-11-9 {source="ChemIDplus"} xref: CAS:81103-11-9 {source="KEGG COMPOUND"} xref: Drug_Central:668 {source="DrugCentral"} xref: DrugBank:DB01211 xref: KEGG:C06912 xref: KEGG:D00276 xref: LINCS:LSM-5606 xref: LIPID_MAPS_instance:LMPK04000014 {source="LIPID MAPS"} xref: Patent:EP41355 xref: Patent:US4331803 xref: PDBeChem:CTY xref: PMID:16387493 {source="ChEMBL"} xref: Reaxys:3581974 {source="Reaxys"} is_a: CHEBI:25105 ! macrolide antibiotic relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C38H69NO13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AGOYDEPGAOXOCK-KCBOHYOISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "747.95340" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "747.47689" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)OC" xsd:string [Term] id: CHEBI:37404 name: elemental copper namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:23377 ! copper molecular entity [Term] id: CHEBI:37407 name: cyclic ether namespace: chebi_ontology alt_id: CHEBI:37406 def: "Any ether in which the oxygen atom forms part of a ring." [] subset: 3_STAR synonym: "cyclic ether" EXACT [IUPAC] synonym: "cyclic ethers" EXACT IUPAC_NAME [IUPAC] synonym: "cyclic ethers" RELATED [ChEBI] synonym: "epoxy compounds" EXACT IUPAC_NAME [IUPAC] synonym: "epoxy compounds" RELATED [ChEBI] is_a: CHEBI:25698 ! ether is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:37416 name: EC 2.7.7.6 (RNA polymerase) inhibitor namespace: chebi_ontology def: "An EC 2.7.7.* (nucleotidyltransferase) inhibitor that interferes with the action of RNA polymerase (EC 2.7.7.6)." [] subset: 3_STAR synonym: "C ribonucleic acid formation factors inhibitor" RELATED [ChEBI] synonym: "C ribonucleic acid formation factors inhibitors" RELATED [ChEBI] synonym: "C RNA formation factors inhibitor" RELATED [ChEBI] synonym: "C RNA formation factors inhibitors" RELATED [ChEBI] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitor" RELATED [ChEBI] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitors" RELATED [ChEBI] synonym: "directed RNA polymerase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "DNA-dependent RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "DNA-dependent RNA polymerase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent RNA polymerase inhibitors" RELATED [ChEBI] synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "DNA-directed RNA polymerase inhibitor" RELATED [ChEBI] synonym: "DNA-directed RNA polymerase inhibitors" RELATED [ChEBI] synonym: "EC 2.7.7.6 (RNA polymerase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.7.6 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.7.6 inhibitors" RELATED [ChEBI] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [ChEBI] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [ChEBI] synonym: "ribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "ribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "ribonucleate polymerase inhibitor" RELATED [ChEBI] synonym: "ribonucleate polymerase inhibitors" RELATED [ChEBI] synonym: "ribonucleic acid nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "ribonucleic acid nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "ribonucleic acid polymerase inhibitor" RELATED [ChEBI] synonym: "ribonucleic acid polymerase inhibitors" RELATED [ChEBI] synonym: "ribonucleic acid transcriptase inhibitor" RELATED [ChEBI] synonym: "ribonucleic acid transcriptase inhibitors" RELATED [ChEBI] synonym: "ribonucleic polymerase inhibitor" RELATED [ChEBI] synonym: "ribonucleic polymerase inhibitors" RELATED [ChEBI] synonym: "ribonucleic transcriptase inhibitor" RELATED [ChEBI] synonym: "ribonucleic transcriptase inhibitors" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "RNA polymerase (EC 2.7.7.6) inhibitor" RELATED [ChEBI] synonym: "RNA polymerase (EC 2.7.7.6) inhibitors" RELATED [ChEBI] synonym: "RNA polymerase I inhibitor" RELATED [ChEBI] synonym: "RNA polymerase I inhibitors" RELATED [ChEBI] synonym: "RNA polymerase II inhibitor" RELATED [ChEBI] synonym: "RNA polymerase II inhibitors" RELATED [ChEBI] synonym: "RNA polymerase III inhibitor" RELATED [ChEBI] synonym: "RNA polymerase III inhibitors" RELATED [ChEBI] synonym: "RNA polymerase inhibitor" RELATED [ChEBI] synonym: "RNA polymerase inhibitors" RELATED [ChEBI] synonym: "RNA transcriptase inhibitor" RELATED [ChEBI] synonym: "RNA transcriptase inhibitors" RELATED [ChEBI] synonym: "transcriptase inhibitor" RELATED [ChEBI] synonym: "transcriptase inhibitors" RELATED [ChEBI] xref: Wikipedia:RNA_polymerase is_a: CHEBI:76815 ! EC 2.7.7.* (nucleotidyltransferase) inhibitor [Term] id: CHEBI:3745 name: clindamycin namespace: chebi_ontology alt_id: CHEBI:47331 def: "A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic." [] subset: 3_STAR synonym: "7(S)-Chloro-7-deoxylincomycin" RELATED [ChemIDplus] synonym: "7-CDL" RELATED [ChemIDplus] synonym: "Cleocin (TN)" RELATED [KEGG_DRUG] synonym: "Clindamycin" EXACT [KEGG_COMPOUND] synonym: "Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside" RELATED [ChemIDplus] synonym: "methyl 7-chloro-6,7,8-trideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-glycero-alpha-D-galacto-octopyranoside" EXACT IUPAC_NAME [IUPAC] xref: CAS:18323-44-9 {source="ChemIDplus"} xref: CAS:18323-44-9 {source="KEGG COMPOUND"} xref: DrugBank:DB01190 xref: HMDB:HMDB0015321 xref: KEGG:C06914 xref: KEGG:C13684 xref: KEGG:D00277 xref: KEGG:D02132 xref: PMID:11691576 {source="Europe PMC"} xref: PMID:18695329 {source="Europe PMC"} xref: PMID:24310902 {source="Europe PMC"} xref: Reaxys:5624049 {source="Reaxys"} xref: Wikipedia:Clindamycin is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:35275 ! S-glycosyl compound is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:46770 ! pyrrolidinecarboxamide is_a: CHEBI:72588 ! semisynthetic derivative relationship: has_functional_parent CHEBI:6472 ! lincomycin relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H33ClN2O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9?,10-,11+,12?,13+,14-,15-,16-,18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDLRVYVGXIQJDK-NOWPCOIGSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "424.98380" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "424.17987" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC(C(C)Cl)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O" xsd:string [Term] id: CHEBI:3749 name: clofazimine namespace: chebi_ontology alt_id: CHEBI:355347 def: "3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients." [] subset: 3_STAR synonym: "(4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine" RELATED [ChEMBL] synonym: "3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine" RELATED [ChemIDplus] synonym: "3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin" RELATED [ChemIDplus] synonym: "clofazimina" RELATED INN [ChemIDplus] synonym: "clofazimine" RELATED INN [ChemIDplus] synonym: "clofaziminum" RELATED INN [ChemIDplus] synonym: "N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine" RELATED [ChEMBL] synonym: "N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:8168151 {source="Beilstein"} xref: CAS:2030-63-9 {source="ChemIDplus"} xref: CAS:2030-63-9 {source="KEGG COMPOUND"} xref: DrugBank:DB00845 xref: KEGG:C06915 xref: KEGG:D00278 xref: LINCS:LSM-5669 xref: Patent:US2948726 xref: PMID:17210775 {source="ChEMBL"} xref: PMID:3279207 {source="ChEMBL"} is_a: CHEBI:39201 ! phenazines is_a: CHEBI:83403 ! monochlorobenzenes relationship: RO:0000087 CHEBI:35475 ! has role non-steroidal anti-inflammatory drug relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug relationship: RO:0000087 CHEBI:37958 ! has role dye property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H22Cl2N4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WDQPAMHFFCXSNU-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "473.39600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "472.12215" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)N=c1cc2n(-c3ccc(Cl)cc3)c3ccccc3nc2cc1Nc1ccc(Cl)cc1" xsd:string [Term] id: CHEBI:37527 name: acid namespace: chebi_ontology alt_id: CHEBI:13800 alt_id: CHEBI:13801 alt_id: CHEBI:22209 alt_id: CHEBI:2426 def: "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." [] subset: 3_STAR synonym: "Acid" EXACT [KEGG_COMPOUND] synonym: "acid" EXACT IUPAC_NAME [IUPAC] synonym: "acide" RELATED [IUPAC] synonym: "acido" RELATED [ChEBI] synonym: "acids" RELATED [ChEBI] synonym: "Saeure" RELATED [ChEBI] synonym: "Saeuren" RELATED [ChEBI] xref: KEGG:C00174 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:37533 name: azo compound namespace: chebi_ontology def: "Derivatives of diazene with the general structure R-N=N-R'." [] subset: 3_STAR synonym: "azo compounds" EXACT IUPAC_NAME [IUPAC] synonym: "azo compounds" RELATED [ChEBI] is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_parent_hydride CHEBI:30096 ! diazene relationship: has_part CHEBI:30106 ! azo group [Term] id: CHEBI:37577 name: heteroatomic molecular entity namespace: chebi_ontology def: "A molecular entity consisting of two or more chemical elements." [] subset: 3_STAR synonym: "chemical compound" RELATED [ChEBI] synonym: "heteroatomic molecular entities" RELATED [ChEBI] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:37578 name: halide namespace: chebi_ontology def: "Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements." [] subset: 3_STAR synonym: "halides" RELATED [ChEBI] xref: Wikipedia:Halide is_a: CHEBI:24471 ! halogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:37622 name: carboxamide namespace: chebi_ontology alt_id: CHEBI:35354 alt_id: CHEBI:35355 def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." [] subset: 3_STAR synonym: "carboxamides" EXACT IUPAC_NAME [IUPAC] synonym: "carboxamides" RELATED [ChEBI] synonym: "primary carboxamide" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound relationship: has_part CHEBI:23004 ! carbamoyl group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "42.01680" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)N([*])[*]" xsd:string [Term] id: CHEBI:37624 name: L-glucose namespace: chebi_ontology subset: 3_STAR synonym: "L(-)-glucose" RELATED [ChemIDplus] synonym: "L-gluco-hexose" EXACT IUPAC_NAME [IUPAC] synonym: "L-glucose" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:1724626 {source="ChemIDplus"} xref: CAS:921-60-8 {source="ChemIDplus"} is_a: CHEBI:17234 ! glucose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string [Term] id: CHEBI:37627 name: L-glucopyranose namespace: chebi_ontology def: "The L-enantiomer of glucopyranose." [] subset: 3_STAR synonym: "L-glucopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "L-glucopyranose" EXACT [UniProt] synonym: "WURCS=2.0/1,1,0/[a1211h-1x_1-5]/1/" RELATED [GlyTouCan] xref: Beilstein:2206321 {source="Beilstein"} xref: GlyGen:G16038XU xref: GlyTouCan:G16038XU xref: Reaxys:2206321 {source="Reaxys"} is_a: CHEBI:37624 ! L-glucose is_a: CHEBI:37661 ! glucopyranose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-ZZWDRFIYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@H]1O" xsd:string [Term] id: CHEBI:37630 name: alpha-L-glucose namespace: chebi_ontology def: "A L-glucopyranose with an alpha-configuration at the anomeric position." [] subset: 3_STAR synonym: "alpha-L-glucopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "WURCS=2.0/1,1,0/[a1211h-1a_1-5]/1/" RELATED [GlyTouCan] xref: Beilstein:1907372 {source="Beilstein"} xref: GlyGen:G15768VA xref: GlyTouCan:G15768VA xref: Reaxys:1907372 {source="Reaxys"} is_a: CHEBI:37627 ! L-glucopyranose relationship: is_enantiomer_of CHEBI:17925 ! alpha-D-glucose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-MDMQIMBFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@H]1O" xsd:string [Term] id: CHEBI:37661 name: glucopyranose namespace: chebi_ontology subset: 3_STAR synonym: "glucopyranose" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:17234 ! glucose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string [Term] id: CHEBI:37670 name: protease inhibitor namespace: chebi_ontology def: "A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases)." [] subset: 3_STAR synonym: "protease inhibitors" RELATED [ChEBI] xref: Wikipedia:Protease_inhibitor_(biology) is_a: CHEBI:60258 ! EC 3.4.* (hydrolases acting on peptide bond) inhibitor [Term] id: CHEBI:37699 name: protein kinase inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases." [] subset: 3_STAR synonym: "protein kinase inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:37734 name: phosphoric ester namespace: chebi_ontology alt_id: CHEBI:26019 subset: 1_STAR is_a: CHEBI:26079 ! phosphoric acid derivative is_a: CHEBI:35701 ! ester [Term] id: CHEBI:37806 name: penicillanic acid namespace: chebi_ontology def: "A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration." [] subset: 3_STAR synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "penicillanic acid" EXACT [ChemIDplus] xref: Beilstein:4677775 {source="Beilstein"} xref: CAS:87-53-6 {source="ChemIDplus"} xref: Reaxys:4677775 {source="Reaxys"} is_a: CHEBI:25865 ! penicillanic acids property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H11NO3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H11NO3S/c1-8(2)6(7(11)12)9-4(10)3-5(9)13-8/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RBKMMJSQKNKNEV-RITPCOANSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "201.24388" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "201.04596" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CC(=O)N1[C@@H](C(O)=O)C(C)(C)S2" xsd:string [Term] id: CHEBI:37826 name: sulfuric acid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfuric acid derivative" EXACT [ChEBI] synonym: "sulfuric acid derivatives" RELATED [ChEBI] is_a: CHEBI:33424 ! sulfur oxoacid derivative relationship: has_functional_parent CHEBI:26836 ! sulfuric acid [Term] id: CHEBI:37838 name: carboacyl group namespace: chebi_ontology def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "carboacyl groups" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acyl group" EXACT IUPAC_NAME [IUPAC] synonym: "carboxylic acyl groups" RELATED [IUPAC] is_a: CHEBI:22221 ! acyl group relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:37848 name: plant hormone namespace: chebi_ontology alt_id: CHEBI:26158 def: "A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds." [] subset: 3_STAR synonym: "phytohormone" RELATED [ChEBI] synonym: "phytohormones" RELATED [ChEBI] synonym: "plant growth factor" RELATED [ChEBI] synonym: "plant growth factors" RELATED [ChEBI] synonym: "plant growth hormone" RELATED [ChEBI] synonym: "plant growth hormones" RELATED [ChEBI] synonym: "plant hormones" RELATED [ChEBI] xref: Wikipedia:Phytohormone is_a: CHEBI:24621 ! hormone is_a: CHEBI:26155 ! plant growth regulator [Term] id: CHEBI:37852 name: organoammonium sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "organoammonium sulfates" RELATED [ChEBI] is_a: CHEBI:46850 ! organoammonium salt is_a: CHEBI:51337 ! organic sulfate salt [Term] id: CHEBI:37912 name: hydroxycoumarin namespace: chebi_ontology alt_id: CHEBI:24691 alt_id: CHEBI:24692 def: "Any coumarin carrying at least one hydroxy substituent." [] subset: 3_STAR synonym: "hydroxycoumarins" RELATED [ChEBI] is_a: CHEBI:23403 ! coumarins [Term] id: CHEBI:37943 name: colistin namespace: chebi_ontology alt_id: CHEBI:34651 alt_id: CHEBI:472593 alt_id: CHEBI:560465 alt_id: CHEBI:566816 alt_id: CHEBI:596826 alt_id: CHEBI:597111 alt_id: CHEBI:600596 alt_id: CHEBI:659853 def: "A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa." [] subset: 3_STAR synonym: "Colistin" EXACT [ChEMBL] synonym: "colistina" RELATED INN [ChemIDplus] synonym: "colistine" RELATED INN [ChemIDplus] synonym: "colistinum" RELATED INN [ChemIDplus] synonym: "polymyxin E" RELATED [ChemIDplus] xref: CAS:1066-17-7 {source="ChemIDplus"} xref: CAS:1264-72-8 {source="ChemIDplus"} xref: CAS:1264-72-8 {source="KEGG COMPOUND"} xref: DrugBank:DB00803 xref: KEGG:C13768 xref: KEGG:D02138 xref: PMID:15825037 {source="Europe PMC"} xref: PMID:16931410 {source="Europe PMC"} xref: PMID:17145797 {source="ChEMBL"} xref: PMID:17562800 {source="ChEMBL"} xref: PMID:17576842 {source="ChEMBL"} xref: PMID:17606684 {source="ChEMBL"} xref: PMID:17620384 {source="ChEMBL"} xref: PMID:17646423 {source="ChEMBL"} xref: PMID:17846127 {source="ChEMBL"} xref: PMID:17876007 {source="ChEMBL"} xref: PMID:18625681 {source="Europe PMC"} xref: PMID:25322351 {source="Europe PMC"} xref: PMID:26252512 {source="Europe PMC"} xref: PMID:26415906 {source="Europe PMC"} xref: PMID:26488563 {source="Europe PMC"} xref: PMID:26730548 {source="Europe PMC"} xref: PMID:27160031 {source="Europe PMC"} xref: PMID:27411324 {source="Europe PMC"} xref: PMID:27480806 {source="Europe PMC"} xref: PMID:27524102 {source="Europe PMC"} xref: PMID:27552304 {source="Europe PMC"} xref: PMID:27684296 {source="Europe PMC"} xref: PMID:27743779 {source="Europe PMC"} xref: PMID:27790432 {source="Europe PMC"} xref: PMID:27793510 {source="Europe PMC"} xref: PMID:27891118 {source="Europe PMC"} xref: PMID:27917926 {source="Europe PMC"} xref: PMID:28018876 {source="Europe PMC"} xref: PMID:28029008 {source="Europe PMC"} xref: PMID:28215823 {source="Europe PMC"} xref: PMID:28257552 {source="Europe PMC"} xref: PMID:28267594 {source="Europe PMC"} xref: PMID:28267779 {source="Europe PMC"} xref: PMID:28300674 {source="Europe PMC"} xref: PMID:28315729 {source="Europe PMC"} xref: PMID:28321410 {source="Europe PMC"} is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:59062 ! polymyxin relationship: has_part CHEBI:59064 ! colistin A relationship: has_part CHEBI:59673 ! colistin B relationship: RO:0000087 CHEBI:50909 ! has role nephrotoxic agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C52H97N16O13R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1154.428" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1153.74210" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C" xsd:string [Term] id: CHEBI:37948 name: oxaspiro compound namespace: chebi_ontology def: "A spiro compound in which at least one of the cyclic components is an oxygen heterocyle." [] subset: 3_STAR synonym: "oxaspiro compounds" RELATED [ChEBI] is_a: CHEBI:33599 ! spiro compound [Term] id: CHEBI:37958 name: dye namespace: chebi_ontology subset: 3_STAR synonym: "colorante" RELATED [ChEBI] synonym: "colorantes" RELATED [ChEBI] synonym: "dyes" RELATED [ChEBI] synonym: "Farbstoff" RELATED [ChEBI] synonym: "Farbstoffe" RELATED [ChEBI] synonym: "teinture" RELATED [ChEBI] synonym: "teintures" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:38012 name: aminoglycoside sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycoside sulfate salts" RELATED [ChEBI] is_a: CHEBI:37852 ! organoammonium sulfate salt [Term] id: CHEBI:38032 name: carbotricyclic compound namespace: chebi_ontology def: "A carbopolyclic compound comprising of three carbocyclic rings." [] subset: 3_STAR synonym: "carbotricyclic compounds" RELATED [ChEBI] is_a: CHEBI:35294 ! carbopolycyclic compound is_a: CHEBI:51959 ! organic tricyclic compound [Term] id: CHEBI:38068 name: antimalarial namespace: chebi_ontology def: "A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human." [] subset: 3_STAR synonym: "antimalarials" RELATED [ChEBI] is_a: CHEBI:64915 ! antiplasmodial drug [Term] id: CHEBI:38070 name: anti-arrhythmia drug namespace: chebi_ontology def: "A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres." [] subset: 3_STAR synonym: "anti-arrhythmia agent" RELATED [ChEBI] synonym: "antiarrhythmic agent" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:38099 name: thiadiazoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound [Term] id: CHEBI:38101 name: organonitrogen heterocyclic compound namespace: chebi_ontology def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." [] subset: 3_STAR synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI] synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38102 name: triazines namespace: chebi_ontology def: "Compounds based on a triazine skeleton." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:50893 ! azaarene [Term] id: CHEBI:38104 name: oxacycle namespace: chebi_ontology def: "Any organic heterocyclic compound containing at least one ring oxygen atom." [] subset: 3_STAR synonym: "heterocyclic organooxygen compounds" RELATED [ChEBI] synonym: "organooxygen heterocyclic compounds" RELATED [ChEBI] synonym: "oxacycles" RELATED [ChEBI] xref: PMID:17134300 {source="Europe PMC"} is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:38106 name: organosulfur heterocyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterocyclic organosulfur compounds" RELATED [ChEBI] synonym: "organosulfur heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33261 ! organosulfur compound [Term] id: CHEBI:38119 name: brassinin namespace: chebi_ontology subset: 3_STAR synonym: "Brassinine" RELATED [ChemIDplus] synonym: "methyl (1H-indol-3-ylmethyl)carbamodithioate" EXACT IUPAC_NAME [IUPAC] synonym: "methyl (1H-indol-3-ylmethyl)dithiocarbamate" RELATED [IUPAC] xref: Beilstein:3611293 {source="Beilstein"} xref: CAS:105748-59-2 {source="ChemIDplus"} is_a: CHEBI:24797 ! indole phytoalexin is_a: CHEBI:38129 ! dithiocarbamic ester property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C11H12N2S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C11H12N2S2/c1-15-11(14)13-7-8-6-12-10-5-3-2-4-9(8)10/h2-6,12H,7H2,1H3,(H,13,14)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QYKQWFZDEDFELK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "236.35846" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "236.04419" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CSC(=S)NCc1c[nH]c2ccccc12" xsd:string [Term] id: CHEBI:38127 name: thiocarbamic ester namespace: chebi_ontology def: "Any organonitrogen compound with formula RS-C(=X)NH2 where X = O (monothiocarbamic esters) or S (dithiocarbamic esters), or their N-substituted derivatives." [] subset: 3_STAR synonym: "thiocarbamate" RELATED [ChEBI] synonym: "thiocarbamates" RELATED [ChEBI] synonym: "thiocarbamic ester" EXACT [ChEBI] is_a: CHEBI:26959 ! thiocarboxylic ester is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38129 name: dithiocarbamic ester namespace: chebi_ontology def: "Any ester derived from a member of the class of dithiocarbamic acids by formal replacement of the -SH group by -SR, where R is an organyl group." [] subset: 3_STAR synonym: "carbamodithioates" RELATED [ChEBI] synonym: "carbamodithioic esters" RELATED [ChEBI] synonym: "dithiocarbamic ester" EXACT [ChEBI] synonym: "dithiocarbamoates" RELATED [ChEBI] is_a: CHEBI:38127 ! thiocarbamic ester [Term] id: CHEBI:38131 name: lactol namespace: chebi_ontology def: "Cyclic hemiacetals formed by intramolecular addition of a hydroxy group to an aldehydic or ketonic carbonyl group. They are thus 1-oxacycloalkan-2-ols or unsaturated analogues." [] subset: 3_STAR synonym: "lactol" EXACT [IUPAC] synonym: "lactols" EXACT IUPAC_NAME [IUPAC] synonym: "lactols" RELATED [ChEBI] xref: Wikipedia:Lactol is_a: CHEBI:5653 ! hemiacetal [Term] id: CHEBI:38161 name: chelator namespace: chebi_ontology alt_id: CHEBI:23090 alt_id: CHEBI:3585 alt_id: CHEBI:6789 def: "A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate." [] subset: 3_STAR synonym: "Chelating agent" RELATED [KEGG_COMPOUND] synonym: "chelating agents" RELATED [ChEBI] synonym: "chelators" RELATED [ChEBI] synonym: "complexon" RELATED [ChEBI] synonym: "Metal chelator" RELATED [KEGG_COMPOUND] xref: KEGG:C00917 xref: KEGG:C02169 is_a: CHEBI:52214 ! ligand [Term] id: CHEBI:38163 name: organic heterotetracyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic heterotetracyclic compounds" RELATED [ChEBI] is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:38164 name: organic heteropentacyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic heteropentacyclic compounds" RELATED [ChEBI] is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:38166 name: organic heteropolycyclic compound namespace: chebi_ontology alt_id: CHEBI:25429 alt_id: CHEBI:38075 subset: 3_STAR synonym: "organic heteropolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33671 ! heteropolycyclic compound [Term] id: CHEBI:38179 name: monocyclic heteroarene namespace: chebi_ontology subset: 3_STAR synonym: "monocyclic heteroarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene [Term] id: CHEBI:38180 name: polycyclic heteroarene namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic heteroarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene [Term] id: CHEBI:38181 name: pyridinemonocarboxylate namespace: chebi_ontology def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of a pyridinemonocarboxylic acid. A 'closed class'." [] subset: 3_STAR synonym: "pyridinemonocarboxylates" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:26420 ! pyridinemonocarboxylic acid [Term] id: CHEBI:38186 name: isonicotinate namespace: chebi_ontology def: "A pyridinemonocarboxylate resulting from the deprotonation of the carboxy group of isonicotinic acid." [] subset: 3_STAR synonym: "4-picolinate" RELATED [MetaCyc] synonym: "4-pyridinecarboxylate" RELATED [MetaCyc] synonym: "gamma-picolinate" RELATED [MetaCyc] synonym: "pyridine-4-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: MetaCyc:CPD-13335 is_a: CHEBI:38181 ! pyridinemonocarboxylate relationship: is_conjugate_base_of CHEBI:6032 ! isonicotinic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H4NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TWBYWOBDOCUKOW-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "122.104" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "122.02475" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=O)(C=1C=CN=CC1)[O-]" xsd:string [Term] id: CHEBI:38215 name: calcium channel blocker namespace: chebi_ontology def: "One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools." [] subset: 3_STAR synonym: "calcium channel antagonist" RELATED [ChEBI] synonym: "calcium channel antagonists" RELATED [ChEBI] synonym: "calcium channel blockers" RELATED [ChEBI] is_a: CHEBI:38808 ! calcium channel modulator is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:38216 name: 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) namespace: chebi_ontology subset: 3_STAR synonym: "3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:1838279 {source="Beilstein"} xref: Gmelin:340935 {source="Gmelin"} is_a: CHEBI:25471 ! naphthalenemonosulfonate relationship: is_conjugate_base_of CHEBI:38217 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C32H22N6O6S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C32H24N6O6S2/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HFHIDKQMGIGARX-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "650.68592" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "650.10532" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1c(cc(c2ccccc12)S([O-])(=O)=O)N=Nc1ccc(cc1)-c1ccc(cc1)N=Nc1cc(c2ccccc2c1N)S([O-])(=O)=O" xsd:string [Term] id: CHEBI:38217 name: 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) namespace: chebi_ontology alt_id: CHEBI:291121 subset: 3_STAR synonym: "3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid)" EXACT IUPAC_NAME [IUPAC] synonym: "congo red" RELATED [ChEMBL] xref: Beilstein:741249 {source="Beilstein"} xref: Gmelin:287844 {source="Gmelin"} is_a: CHEBI:36336 ! naphthalenesulfonic acid relationship: is_conjugate_acid_of CHEBI:38216 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C32H24N6O6S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C32H24N6O6S2/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HFHIDKQMGIGARX-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "652.70180" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "652.11987" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1c(cc(c2ccccc12)S(O)(=O)=O)N=Nc1ccc(cc1)-c1ccc(cc1)N=Nc1cc(c2ccccc2c1N)S(O)(=O)=O" xsd:string [Term] id: CHEBI:38218 name: isophthalonitrile namespace: chebi_ontology subset: 3_STAR synonym: "1,3-Benzenedicarbonitrile" RELATED [NIST_Chemistry_WebBook] synonym: "1,3-Dicyanobenzene" RELATED [ChemIDplus] synonym: "3-Cyanobenzonitrile" RELATED [ChemIDplus] synonym: "benzene-1,3-dicarbonitrile" EXACT IUPAC_NAME [IUPAC] synonym: "IPN" RELATED [NIST_Chemistry_WebBook] synonym: "Isophthalodinitrile" RELATED [NIST_Chemistry_WebBook] synonym: "m-Dicyanobenzene" RELATED [ChemIDplus] xref: Beilstein:2038364 {source="Beilstein"} xref: CAS:626-17-5 {source="ChemIDplus"} xref: CAS:626-17-5 {source="NIST Chemistry WebBook"} is_a: CHEBI:18379 ! nitrile relationship: has_functional_parent CHEBI:30802 ! isophthalic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H4N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H4N2/c9-5-7-2-1-3-8(4-7)6-10/h1-4H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LAQPNDIUHRHNCV-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "128.13084" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "128.03745" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N#Cc1cccc(c1)C#N" xsd:string [Term] id: CHEBI:38231 name: phytotoxin namespace: chebi_ontology def: "Any toxin produced by a plant." [] subset: 3_STAR synonym: "phytotoxins" RELATED [ChEBI] is_a: CHEBI:27026 ! toxin is_a: CHEBI:76924 ! plant metabolite [Term] id: CHEBI:38260 name: pyrrolidines namespace: chebi_ontology alt_id: CHEBI:26922 alt_id: CHEBI:38191 def: "Any of a class of heterocyclic amines having a saturated five-membered ring." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38261 name: imidazolidines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38304 ! diazolidine [Term] id: CHEBI:38295 name: azabicycloalkane namespace: chebi_ontology subset: 3_STAR synonym: "azabicycloalkanes" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38298 name: benzodioxoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:38304 name: diazolidine namespace: chebi_ontology subset: 3_STAR synonym: "diazolidines" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38311 name: cephem namespace: chebi_ontology subset: 3_STAR synonym: "cephems" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:27933 ! beta-lactam antibiotic is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:38313 name: diazines namespace: chebi_ontology def: "Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure)." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38314 name: pyrazines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38313 ! diazines [Term] id: CHEBI:38329 name: oxazolidines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:38337 name: pyrimidone namespace: chebi_ontology def: "A pyrimidine carrying one or more oxo substituents." [] subset: 3_STAR synonym: "pyrimidones" RELATED [ChEBI] is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:38338 name: aminopyrimidine namespace: chebi_ontology def: "A member of the class of pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives." [] subset: 3_STAR synonym: "aminopyrimidines" RELATED [ChEBI] is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:38418 name: 1,3-thiazoles namespace: chebi_ontology alt_id: CHEBI:26949 alt_id: CHEBI:38417 subset: 3_STAR synonym: "1,3-thiazoles" EXACT [ChEBI] is_a: CHEBI:48901 ! thiazoles [Term] id: CHEBI:38443 name: 1-benzopyran namespace: chebi_ontology subset: 3_STAR synonym: "1-benzopyrans" RELATED [ChEBI] is_a: CHEBI:22727 ! benzopyran [Term] id: CHEBI:38445 name: chromenone namespace: chebi_ontology subset: 3_STAR synonym: "chromenones" RELATED [ChEBI] is_a: CHEBI:23232 ! chromenes [Term] id: CHEBI:38496 name: electron-transport chain inhibitor namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:38497 name: respiratory-chain inhibitor namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:38496 ! electron-transport chain inhibitor [Term] id: CHEBI:38498 name: mitochondrial NADH:ubiquinone reductase inhibitor namespace: chebi_ontology subset: 3_STAR synonym: "mitochondrial complex I inhibitor" RELATED [ChEBI] synonym: "mitochondrial complex I inhibitors" RELATED [ChEBI] synonym: "mitochondrial NADH dehydrogenase inhibitor" RELATED [ChEBI] is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:38503 ! EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor [Term] id: CHEBI:38499 name: mitochondrial cytochrome-bc1 complex inhibitor namespace: chebi_ontology subset: 3_STAR synonym: "mitochondrial complex III inhibitor" RELATED [ChEBI] synonym: "mitochondrial complex III inhibitors" RELATED [ChEBI] is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:38502 ! cytochrome-bc1 complex inhibitor [Term] id: CHEBI:38500 name: EC 1.9.3.1 (cytochrome c oxidase) inhibitor namespace: chebi_ontology alt_id: CHEBI:38501 alt_id: CHEBI:62966 def: "An EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor that interferes with the action of cytochrome c oxidase (EC 1.9.3.1)." [] subset: 3_STAR synonym: "CcO inhibitor" RELATED [ChEBI] synonym: "complex IV (mitochondrial electron transport) inhibitor" RELATED [ChEBI] synonym: "complex IV (mitochondrial electron transport) inhibitors" RELATED [ChEBI] synonym: "cytochrome a3 inhibitor" RELATED [ChEBI] synonym: "cytochrome a3 inhibitors" RELATED [ChEBI] synonym: "cytochrome aa3 inhibitor" RELATED [ChEBI] synonym: "cytochrome aa3 inhibitors" RELATED [ChEBI] synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitor" RELATED [ChEBI] synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitors" RELATED [ChEBI] synonym: "cytochrome c oxidase inhibitor" RELATED [ChEBI] synonym: "cytochrome c oxidase inhibitors" RELATED [ChEBI] synonym: "cytochrome oxidase inhibitor" RELATED [ChEBI] synonym: "cytochrome oxidase inhibitors" RELATED [ChEBI] synonym: "cytochrome-c oxidase inhibitor" RELATED [ChEBI] synonym: "cytochrome-c oxidase inhibitors" RELATED [ChEBI] synonym: "EC 1.9.3.1 (cytochrome c oxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.3.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.9.3.1 inhibitors" RELATED [ChEBI] synonym: "ferrocytochrome c oxidase inhibitor" RELATED [ChEBI] synonym: "ferrocytochrome c oxidase inhibitors" RELATED [ChEBI] synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitor" RELATED [ChEBI] synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitors" RELATED [ChEBI] synonym: "indophenol oxidase inhibitor" RELATED [ChEBI] synonym: "indophenol oxidase inhibitors" RELATED [ChEBI] synonym: "indophenolase inhibitor" RELATED [ChEBI] synonym: "indophenolase inhibitors" RELATED [ChEBI] synonym: "mitochondrial complex IV inhibitor" RELATED [ChEBI] synonym: "mitochondrial complex IV inhibitors" RELATED [ChEBI] synonym: "mitochondrial cytochrome-c oxidase inhibitors" RELATED [ChEBI] synonym: "NADH cytochrome c oxidase inhibitor" RELATED [ChEBI] synonym: "NADH cytochrome c oxidase inhibitors" RELATED [ChEBI] synonym: "Warburg's respiratory enzyme inhibitor" RELATED [ChEBI] synonym: "Warburg's respiratory enzyme inhibitors" RELATED [ChEBI] xref: PMID:12969439 {source="Europe PMC"} xref: Wikipedia:Cytochrome_c_oxidase is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:76870 ! EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor [Term] id: CHEBI:38502 name: cytochrome-bc1 complex inhibitor namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:38497 ! respiratory-chain inhibitor [Term] id: CHEBI:38503 name: EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor namespace: chebi_ontology def: "A respiratory-chain inhibitor that interferes with the action of the the enzyme NADH:ubiquinone reductase (H(+)-translocating), EC 1.6.5.3." [] subset: 3_STAR synonym: "coenzyme Q reductase" RELATED [ChEBI] synonym: "complex 1 dehydrogenase inhibitor" RELATED [ChEBI] synonym: "complex I (electron transport chain) inhibitors" RELATED [ChEBI] synonym: "complex I (mitochondrial electron transport) inhibitors" RELATED [ChEBI] synonym: "complex I (NADH:Q1 oxidoreductase) inhibitors" RELATED [ChEBI] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "DPNH-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "DPNH-ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitors" RELATED [ChEBI] synonym: "EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitors" RELATED [ChEBI] synonym: "EC 1.6.5.3 inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.3 inhibitors" RELATED [ChEBI] synonym: "electron transfer complex I inhibitor" RELATED [ChEBI] synonym: "electron transfer complex I inhibitors" RELATED [ChEBI] synonym: "mitochondrial electron transport complex 1 inhibitor" RELATED [ChEBI] synonym: "mitochondrial electron transport complex I inhibitor" RELATED [ChEBI] synonym: "mitochondrial electron transport complex I inhibitors" RELATED [ChEBI] synonym: "NADH coenzyme Q1 reductase inhibitor" RELATED [ChEBI] synonym: "NADH coenzyme Q1 reductase inhibitors" RELATED [ChEBI] synonym: "NADH dehydrogenase (ubiquinone) inhibitor" RELATED [ChEBI] synonym: "NADH dehydrogenase (ubiquinone) inhibitors" RELATED [ChEBI] synonym: "NADH-coenzyme Q oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "NADH-coenzyme Q reductase inhibitors" RELATED [ChEBI] synonym: "NADH-CoQ oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH-CoQ oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH-CoQ reductase inhibitor" RELATED [ChEBI] synonym: "NADH-CoQ reductase inhibitors" RELATED [ChEBI] synonym: "NADH-Q6 oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH-ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone reductase inhibitors" RELATED [ChEBI] synonym: "NADH-ubiquinone-1 reductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone-1 reductase inhibitors" RELATED [ChEBI] synonym: "NADH2 dehydrogenase (ubiquinone) inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone oxidoreductase complex inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase (H(+)-translocating) inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase (H(+)-translocating) inhibitors" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase (H+-translocating) inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitors" RELATED [ChEBI] synonym: "type 1 dehydrogenase inhibitor" RELATED [ChEBI] synonym: "type 1 dehydrogenase inhibitors" RELATED [ChEBI] synonym: "ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "ubiquinone reductase inhibitors" RELATED [ChEBI] xref: Wikipedia:NADH_dehydrogenase_(ubiquinone) is_a: CHEBI:38497 ! respiratory-chain inhibitor is_a: CHEBI:76866 ! EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor [Term] id: CHEBI:38532 name: hydrazone namespace: chebi_ontology def: "Compounds having the structure R2C=NNR2, formally derived from aldehydes or ketones by replacing =O by =NNH2 (or substituted analogues)." [] subset: 3_STAR synonym: "hydrazones" EXACT IUPAC_NAME [IUPAC] synonym: "hydrazones" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38582 name: difluorobenzene namespace: chebi_ontology def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying two fluorine atoms." [] subset: 3_STAR synonym: "Difluorbenzol" RELATED [ChEBI] synonym: "difluorobenzene" EXACT IUPAC_NAME [IUPAC] synonym: "difluorobenzenes" RELATED [ChEBI] is_a: CHEBI:35496 ! fluorobenzenes [Term] id: CHEBI:38584 name: 1,3-difluorobenzene namespace: chebi_ontology def: "A difluorobenzene carrying fluoro groups at positions 1 and 3." [] subset: 3_STAR synonym: "1,3-Difluorbenzol" RELATED [ChEBI] synonym: "1,3-difluorobenzene" EXACT IUPAC_NAME [IUPAC] synonym: "m-difluorobenzene" RELATED [ChemIDplus] synonym: "meta-difluorobenzene" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:1904537 {source="Beilstein"} xref: CAS:372-18-9 {source="ChemIDplus"} xref: CAS:372-18-9 {source="NIST Chemistry WebBook"} xref: Gmelin:200891 {source="Gmelin"} xref: Patent:CN101607874 xref: Patent:CN1634895 xref: Patent:CN1765887 xref: PMID:15535712 {source="Europe PMC"} xref: PMID:22707282 {source="Europe PMC"} xref: Reaxys:1904537 {source="Reaxys"} is_a: CHEBI:38582 ! difluorobenzene property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H4F2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H4F2/c7-5-2-1-3-6(8)4-5/h1-4H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UEMGWPRHOOEKTA-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "114.09277" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "114.02811" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Fc1cccc(F)c1" xsd:string [Term] id: CHEBI:38597 name: triazole namespace: chebi_ontology subset: 3_STAR synonym: "triazole" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35555 ! mancude organic heteromonocyclic parent is_a: CHEBI:35727 ! triazoles property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3N3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "69.065" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "69.03270" xsd:string [Term] id: CHEBI:38623 name: EC 1.4.3.4 (monoamine oxidase) inhibitor namespace: chebi_ontology def: "An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4)." [] subset: 3_STAR synonym: "adrenalin oxidase inhibitor" RELATED [ChEBI] synonym: "adrenalin oxidase inhibitors" RELATED [ChEBI] synonym: "adrenaline oxidase inhibitor" RELATED [ChEBI] synonym: "adrenaline oxidase inhibitors" RELATED [ChEBI] synonym: "amine oxidase (flavin-containing) inhibitor" RELATED [ChEBI] synonym: "amine oxidase (flavin-containing) inhibitors" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitor" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitors" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) inhibitor" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.3.4 (monoamine oxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.3.4 inhibitor" RELATED [ChEBI] synonym: "EC 1.4.3.4 inhibitors" RELATED [ChEBI] synonym: "epinephrine oxidase inhibitor" RELATED [ChEBI] synonym: "epinephrine oxidase inhibitors" RELATED [ChEBI] synonym: "MAO A inhibitor" RELATED [ChEBI] synonym: "MAO A inhibitors" RELATED [ChEBI] synonym: "MAO B inhibitor" RELATED [ChEBI] synonym: "MAO B inhibitors" RELATED [ChEBI] synonym: "MAO inhibitor" RELATED [ChEBI] synonym: "MAO inhibitors" RELATED [ChEBI] synonym: "MAO-A inhibitor" RELATED [ChEBI] synonym: "MAO-A inhibitors" RELATED [ChEBI] synonym: "MAO-B inhibitor" RELATED [ChEBI] synonym: "MAO-B inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase (EC 1.4.3.4) inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase (EC 1.4.3.4) inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase A inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase A inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase B inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase B inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase inhibitors" RELATED [ChEBI] synonym: "monoamine:O2 oxidoreductase (deaminating) inhibitor" RELATED [ChEBI] synonym: "monoamine:O2 oxidoreductase (deaminating) inhibitors" RELATED [ChEBI] synonym: "serotonin deaminase inhibitor" RELATED [ChEBI] synonym: "serotonin deaminase inhibitors" RELATED [ChEBI] synonym: "tyraminase inhibitor" RELATED [ChEBI] synonym: "tyraminase inhibitors" RELATED [ChEBI] synonym: "tyramine oxidase inhibitor" RELATED [ChEBI] synonym: "tyramine oxidase inhibitors" RELATED [ChEBI] xref: Wikipedia:Monoamine_oxidase_inhibitor is_a: CHEBI:76861 ! EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor [Term] id: CHEBI:38632 name: membrane transport modulator namespace: chebi_ontology def: "Any agent that affects the transport of molecular entities across a biological membrane." [] subset: 3_STAR synonym: "membrane transport modulators" RELATED [ChEBI] is_a: CHEBI:52208 ! biophysical role [Term] id: CHEBI:38700 name: organic sodium salt namespace: chebi_ontology subset: 3_STAR synonym: "organic sodium salt" EXACT [ChEBI] synonym: "organic sodium salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:26714 ! sodium salt [Term] id: CHEBI:38702 name: inorganic sodium salt namespace: chebi_ontology subset: 3_STAR synonym: "inorganic sodium salts" RELATED [ChEBI] is_a: CHEBI:24839 ! inorganic salt is_a: CHEBI:26714 ! sodium salt [Term] id: CHEBI:38716 name: carboxylic acid dianion namespace: chebi_ontology def: "Any dianion containing at least one carboxy group." [] subset: 3_STAR synonym: "carboxylic acid dianion" EXACT [ChEBI] synonym: "carboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:38773 name: quinolinemonocarboxylate namespace: chebi_ontology def: "A monocarboxylic acid anion that is the monoanion obtained by the deprotonation of the carboxy group attached to the quinoline skeleton" [] subset: 3_STAR synonym: "quinolinemonocarboxylates" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:26512 ! quinolinemonocarboxylic acid [Term] id: CHEBI:38785 name: morpholines namespace: chebi_ontology def: "Any compound containing morpholine as part of its structure." [] subset: 3_STAR is_a: CHEBI:46952 ! oxazinane [Term] id: CHEBI:38808 name: calcium channel modulator namespace: chebi_ontology def: "A membrane transport modulator that is able to regulate intracellular calcium levels." [] subset: 3_STAR synonym: "calcium channel modulators" RELATED [ChEBI] is_a: CHEBI:38632 ! membrane transport modulator [Term] id: CHEBI:38922 name: dibenzofurans namespace: chebi_ontology def: "Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof." [] subset: 3_STAR is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:39141 name: Bronsted acid namespace: chebi_ontology def: "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." [] subset: 3_STAR synonym: "acide de Bronsted" RELATED [IUPAC] synonym: "Bronsted acid" EXACT IUPAC_NAME [IUPAC] synonym: "Bronsted-Saeure" RELATED [ChEBI] synonym: "donneur d'hydron" RELATED [IUPAC] synonym: "hydron donor" RELATED [IUPAC] is_a: CHEBI:17891 ! donor is_a: CHEBI:37527 ! acid [Term] id: CHEBI:39142 name: Bronsted base namespace: chebi_ontology def: "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." [] subset: 3_STAR synonym: "accepteur d'hydron" RELATED [IUPAC] synonym: "base de Bronsted" RELATED [IUPAC] synonym: "Bronsted base" EXACT IUPAC_NAME [IUPAC] synonym: "Bronsted-Base" RELATED [ChEBI] synonym: "hydron acceptor" RELATED [IUPAC] is_a: CHEBI:15339 ! acceptor is_a: CHEBI:22695 ! base [Term] id: CHEBI:39144 name: Lewis base namespace: chebi_ontology def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." [] subset: 3_STAR synonym: "base de Lewis" RELATED [IUPAC] synonym: "donneur d'une paire d'electrons" RELATED [ChEBI] synonym: "electron donor" RELATED [ChEBI] synonym: "Lewis base" EXACT IUPAC_NAME [IUPAC] synonym: "Lewis-Base" RELATED [ChEBI] is_a: CHEBI:17891 ! donor is_a: CHEBI:22695 ! base [Term] id: CHEBI:39146 name: trichostatin namespace: chebi_ontology subset: 3_STAR synonym: "trichostatin" EXACT [ChEBI] synonym: "trichostatins" RELATED [ChEBI] is_a: CHEBI:49319 ! carbocyclic antibiotic [Term] id: CHEBI:39157 name: trichostatic acid namespace: chebi_ontology subset: 3_STAR synonym: "(+-)-7-(4-(dimethylamino)phenyl)-4,6-dimethyl-7-oxo-2,4-heptadienoic acid" RELATED [ChemIDplus] synonym: "(2E,4E)-7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxohepta-2,4-dienoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "trichostatic acid" EXACT [ChemIDplus] xref: Beilstein:2386556 {source="Beilstein"} xref: CAS:114127-17-2 {source="ChemIDplus"} is_a: CHEBI:35983 ! 7-oxo monocarboxylic acid is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H21NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H21NO3/c1-12(5-10-16(19)20)11-13(2)17(21)14-6-8-15(9-7-14)18(3)4/h5-11,13H,1-4H3,(H,19,20)/b10-5+,12-11+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VKEITMNFEJHFCX-WKWSCTOISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "287.35358" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "287.15214" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C(=O)c1ccc(cc1)N(C)C)\\C=C(C)\\C=C\\C(O)=O" xsd:string [Term] id: CHEBI:39158 name: (R)-trichostatic acid namespace: chebi_ontology subset: 3_STAR synonym: "(+)-trichostatic acid" RELATED [ChEBI] synonym: "(+)-Trichostatsaeure" RELATED [ChEBI] synonym: "(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxohepta-2,4-dienoic acid" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:5284073 {source="Beilstein"} xref: Beilstein:6893749 {source="Beilstein"} is_a: CHEBI:39157 ! trichostatic acid relationship: is_enantiomer_of CHEBI:39159 ! (S)-trichostatic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H21NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H21NO3/c1-12(5-10-16(19)20)11-13(2)17(21)14-6-8-15(9-7-14)18(3)4/h5-11,13H,1-4H3,(H,19,20)/b10-5+,12-11+/t13-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VKEITMNFEJHFCX-QEQCGCAPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "287.35358" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "287.15214" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](C(=O)c1ccc(cc1)N(C)C)\\C=C(C)\\C=C\\C(O)=O" xsd:string [Term] id: CHEBI:39159 name: (S)-trichostatic acid namespace: chebi_ontology subset: 3_STAR synonym: "(-)-trichostatic acid" RELATED [ChEBI] synonym: "(-)-Trichostatsaeure" RELATED [ChEBI] synonym: "(2E,4E,6S)-7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxohepta-2,4-dienoic acid" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:5284074 {source="Beilstein"} is_a: CHEBI:39157 ! trichostatic acid relationship: is_enantiomer_of CHEBI:39158 ! (R)-trichostatic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H21NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H21NO3/c1-12(5-10-16(19)20)11-13(2)17(21)14-6-8-15(9-7-14)18(3)4/h5-11,13H,1-4H3,(H,19,20)/b10-5+,12-11+/t13-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VKEITMNFEJHFCX-LEJRBOCMSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "287.35358" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "287.15214" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H](C(=O)c1ccc(cc1)N(C)C)\\C=C(C)\\C=C\\C(O)=O" xsd:string [Term] id: CHEBI:39201 name: phenazines namespace: chebi_ontology def: "Any organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives." [] subset: 3_STAR is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:39208 name: antibiotic insecticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24852 ! insecticide is_a: CHEBI:39215 ! antibiotic pesticide [Term] id: CHEBI:39209 name: macrolide insecticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39221 ! macrolide pesticide relationship: RO:0000087 CHEBI:39208 ! has role antibiotic insecticide [Term] id: CHEBI:39213 name: avermectin insecticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39209 ! macrolide insecticide is_a: CHEBI:39220 ! avermectin pesticide [Term] id: CHEBI:39214 name: abamectin namespace: chebi_ontology def: "Mixture of 80% avermectin B1a and 20% avermectin B1b." [] subset: 3_STAR synonym: "Abamectin" EXACT [ChemIDplus] synonym: "Agri-Mek" RELATED [ChemIDplus] synonym: "avermectin B1" RELATED [ChemIDplus] synonym: "Avid" RELATED [ChemIDplus] synonym: "MK 936" RELATED [ChemIDplus] synonym: "Zephyr" RELATED [ChemIDplus] xref: CAS:71751-41-2 {source="ChemIDplus"} is_a: CHEBI:39213 ! avermectin insecticide is_a: CHEBI:39219 ! avermectin acaricide is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:29534 ! avermectin B1a relationship: has_part CHEBI:29537 ! avermectin B1b relationship: RO:0000087 CHEBI:39217 ! has role antibiotic nematicide [Term] id: CHEBI:39215 name: antibiotic pesticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25944 ! pesticide is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:39216 name: antibiotic acaricide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:22153 ! acaricide is_a: CHEBI:39215 ! antibiotic pesticide [Term] id: CHEBI:39217 name: antibiotic nematicide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25491 ! nematicide is_a: CHEBI:39215 ! antibiotic pesticide [Term] id: CHEBI:39218 name: macrolide acaricide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39221 ! macrolide pesticide relationship: RO:0000087 CHEBI:39216 ! has role antibiotic acaricide [Term] id: CHEBI:39219 name: avermectin acaricide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39218 ! macrolide acaricide is_a: CHEBI:39220 ! avermectin pesticide [Term] id: CHEBI:39220 name: avermectin pesticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39221 ! macrolide pesticide [Term] id: CHEBI:39221 name: macrolide pesticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25105 ! macrolide antibiotic [Term] id: CHEBI:39230 name: emamectin namespace: chebi_ontology def: "A mixture of emamectin B1a (major component) and emamectin B1b (minor component)." [] subset: 3_STAR synonym: "(4''R)- 4''-deoxy-4''-(methylamino)avermectin B1" RELATED [ChemIDplus] synonym: "4''-epi-methylamino-4''-deoxyavermectin B1" RELATED [ChemIDplus] synonym: "emamectin" EXACT [ChemIDplus] xref: CAS:119791-41-2 {source="ChemIDplus"} xref: CAS:137335-79-6 {source="ChemIDplus"} is_a: CHEBI:39213 ! avermectin insecticide relationship: has_part CHEBI:39231 ! emamectin B1a relationship: has_part CHEBI:39232 ! emamectin B1b [Term] id: CHEBI:39231 name: emamectin B1a namespace: chebi_ontology subset: 3_STAR synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylamino)-alpha-L-arabino-hexopyranosyl]-alpha-L-arabino-hexopyranoside" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:8671728 {source="Beilstein"} is_a: CHEBI:50346 ! emamectins property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C49H75NO13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C49H75NO13/c1-12-26(2)44-29(5)18-19-48(63-44)24-35-21-34(62-48)17-16-28(4)43(27(3)14-13-15-33-25-56-46-42(51)30(6)20-36(47(52)59-35)49(33,46)53)60-40-23-38(55-11)45(32(8)58-40)61-39-22-37(54-10)41(50-9)31(7)57-39/h13-16,18-20,26-27,29,31-32,34-46,50-51,53H,12,17,21-25H2,1-11H3/b14-13+,28-16+,33-15+/t26-,27-,29-,31-,32-,34+,35-,36-,37-,38-,39-,40-,41-,42+,43-,44+,45-,46+,48+,49+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CXEGAUYXQAKHKJ-NSBHKLITSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "886.11874" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "885.52384" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C\\C=C(C)\\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](NC)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\\C=C\\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(O2)O[C@]([H])([C@@H](C)CC)[C@@H](C)C=C1)[C@]34O" xsd:string [Term] id: CHEBI:39232 name: emamectin B1b namespace: chebi_ontology subset: 3_STAR synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-6'-(propan-2-yl)-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylamino)-alpha-L-arabino-hexopyranosyl]-alpha-L-arabino-hexopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylamino)-alpha-L-arabino-hexopyranosyl]-alpha-L-arabino-hexopyranoside" RELATED [IUPAC] is_a: CHEBI:50346 ! emamectins property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C48H73NO13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C48H73NO13/c1-25(2)42-28(5)17-18-47(62-42)23-34-20-33(61-47)16-15-27(4)43(26(3)13-12-14-32-24-55-45-41(50)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-11)44(31(8)57-39)60-38-21-36(53-10)40(49-9)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,16,20-24H2,1-11H3/b13-12+,27-15+,32-14+/t26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,47+,48+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DXIOOXFZLKCVHK-UTAOKEBVSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "872.09216" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "871.50819" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C\\C=C(C)\\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](NC)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\\C=C\\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(O2)O[C@]([H])(C(C)C)[C@@H](C)C=C1)[C@]34O" xsd:string [Term] id: CHEBI:39270 name: naphthofuran namespace: chebi_ontology subset: 3_STAR synonym: "naphthofurans" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:39317 name: growth regulator namespace: chebi_ontology def: "Any chemical substance that inhibits the life-cycle of an organism." [] subset: 3_STAR synonym: "growth regulators" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:39410 name: 1,2,4-triazines namespace: chebi_ontology def: "Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure." [] subset: 3_STAR xref: PMID:20194696 {source="Europe PMC"} is_a: CHEBI:38102 ! triazines [Term] id: CHEBI:39418 name: straight-chain saturated fatty acid namespace: chebi_ontology def: "Any saturated fatty acid lacking a side-chain." [] subset: 3_STAR synonym: "straight-chain saturated fatty acid" EXACT [ChEBI] synonym: "straight-chain saturated fatty acids" RELATED [ChEBI] xref: PMID:15644336 {source="Europe PMC"} is_a: CHEBI:26607 ! saturated fatty acid is_a: CHEBI:59202 ! straight-chain fatty acid relationship: is_conjugate_acid_of CHEBI:58954 ! straight-chain saturated fatty acid anion [Term] id: CHEBI:39430 name: dioxolane namespace: chebi_ontology subset: 3_STAR synonym: "dioxolanes" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:39442 name: fluorescent probe namespace: chebi_ontology def: "A role played by a fluorescent molecular entity used to study the microscopic environment by fluorescence spectroscopy." [] subset: 3_STAR is_a: CHEBI:50406 ! probe [Term] id: CHEBI:39446 name: pyrimidine ribonucleosides namespace: chebi_ontology alt_id: CHEBI:13784 alt_id: CHEBI:26445 alt_id: CHEBI:7263 subset: 3_STAR is_a: CHEBI:18254 ! ribonucleoside is_a: CHEBI:26440 ! pyrimidine nucleoside [Term] id: CHEBI:39447 name: pyrimidines namespace: chebi_ontology alt_id: CHEBI:13681 alt_id: CHEBI:26448 def: "Any compound having a pyrimidine as part of its structure." [] subset: 3_STAR is_a: CHEBI:38313 ! diazines [Term] id: CHEBI:39474 name: polyazaalkane namespace: chebi_ontology def: "Any azaalkane in which two or more carbons in the chain are replaced by nitrogen." [] subset: 3_STAR synonym: "polyazaalkanes" RELATED [ChEBI] is_a: CHEBI:46686 ! azaalkane is_a: CHEBI:88061 ! polyamine [Term] id: CHEBI:39745 name: dihydrogenphosphate namespace: chebi_ontology alt_id: CHEBI:29137 alt_id: CHEBI:39739 def: "A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated." [] subset: 3_STAR synonym: "[PO2(OH)2](-)" RELATED [IUPAC] synonym: "dihydrogen(tetraoxidophosphate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "dihydrogenphosphate" EXACT IUPAC_NAME [IUPAC] synonym: "DIHYDROGENPHOSPHATE ION" RELATED [PDBeChem] synonym: "dihydrogentetraoxophosphate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "dihydrogentetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC] synonym: "dihydroxidodioxidophosphate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "H2PO4(-)" RELATED [IUPAC] xref: DrugBank:DB02831 xref: Gmelin:1999 {source="Gmelin"} xref: PDBeChem:2HP is_a: CHEBI:35780 ! phosphate ion is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:43474 ! hydrogenphosphate property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "96.98724" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.96962" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP([O-])(=O)O[H]" xsd:string [Term] id: CHEBI:3992 name: cyclic ketone namespace: chebi_ontology subset: 3_STAR synonym: "Cyclic ketone" EXACT [KEGG_COMPOUND] synonym: "cyclic ketones" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C02019 is_a: CHEBI:17087 ! ketone [Term] id: CHEBI:40009 name: D-cycloserine namespace: chebi_ontology alt_id: CHEBI:4030 def: "A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis)." [] subset: 3_STAR synonym: "(+)-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "(+)-cycloserine" RELATED [ChEBI] synonym: "(4R)-4-aminoisoxazolidin-3-one" EXACT IUPAC_NAME [IUPAC] synonym: "(R)-4-AMINO-ISOXAZOLIDIN-3-ONE" RELATED [PDBeChem] synonym: "alpha-Cycloserine" RELATED [NIST_Chemistry_WebBook] synonym: "cicloserina" RELATED INN [ChemIDplus] synonym: "cyclo-D-serine" RELATED [ChemIDplus] synonym: "cycloserine" RELATED INN [ChemIDplus] synonym: "cycloserine" RELATED INN [WHO_MedNet] synonym: "cycloserinum" RELATED INN [ChemIDplus] synonym: "D-(+)-cycloserine" RELATED [ChEBI] synonym: "D-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "D-4-amino-3-isoxazolidone" RELATED [ChemIDplus] synonym: "D-Cycloserine" EXACT [KEGG_COMPOUND] synonym: "D-Cycloserine" EXACT [ChemIDplus] synonym: "DCS" RELATED [ChemIDplus] synonym: "orientomycin" RELATED [ChemIDplus] synonym: "PA 94" RELATED [ChemIDplus] synonym: "PA-94" RELATED [ChemIDplus] synonym: "Ro-1-9213" RELATED [ChemIDplus] synonym: "Seromycin" RELATED BRAND_NAME [ChemIDplus] xref: Beilstein:80798 {source="Beilstein"} xref: CAS:68-41-7 {source="NIST Chemistry WebBook"} xref: CAS:68-41-7 {source="ChemIDplus"} xref: Drug_Central:759 {source="DrugCentral"} xref: DrugBank:DB00260 xref: HMDB:HMDB0014405 xref: KEGG:D00877 xref: LINCS:LSM-5932 xref: LIPID_MAPS_instance:LMPK14000007 {source="LIPID MAPS"} xref: MetaCyc:CPD-2482 xref: Patent:US2772280 xref: Patent:US2840565 xref: PDBeChem:4AX xref: PMID:12076471 {source="Europe PMC"} xref: PMID:17707326 {source="Europe PMC"} xref: PMID:18316423 {source="Europe PMC"} xref: PMID:18486041 {source="Europe PMC"} xref: PMID:18930757 {source="Europe PMC"} xref: PMID:22234379 {source="Europe PMC"} xref: PMID:22368237 {source="Europe PMC"} xref: PMID:22632472 {source="Europe PMC"} xref: PMID:22892161 {source="Europe PMC"} xref: PMID:23174090 {source="Europe PMC"} xref: PMID:23416058 {source="Europe PMC"} xref: PMID:23438729 {source="Europe PMC"} xref: PMID:23523746 {source="Europe PMC"} xref: PMID:23542909 {source="Europe PMC"} xref: PMID:23656850 {source="Europe PMC"} xref: PMID:23685206 {source="Europe PMC"} xref: PMID:4555420 {source="Europe PMC"} xref: PMID:5006234 {source="Europe PMC"} xref: Reaxys:80798 {source="Reaxys"} xref: Wikipedia:Cycloserine is_a: CHEBI:23503 ! 4-amino-1,2-oxazolidin-3-one is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic relationship: is_conjugate_base_of CHEBI:75929 ! D-cycloserine(1+) relationship: is_enantiomer_of CHEBI:75592 ! L-cycloserine relationship: is_tautomer_of CHEBI:74159 ! D-cycloserine zwitterion relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35221 ! has role antimetabolite relationship: RO:0000087 CHEBI:64571 ! has role NMDA receptor agonist property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYDCUQKUCUHJBH-UWTATZPHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "102.09190" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.04293" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(N)CONC1=O" xsd:string [Term] id: CHEBI:4031 name: cyclosporin A namespace: chebi_ontology alt_id: CHEBI:63586 alt_id: CHEBI:91802 def: "A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle." [] subset: 3_STAR synonym: "(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)" RELATED [ChEBI] synonym: "1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]" RELATED [JCBN] synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" EXACT IUPAC_NAME [IUPAC] synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" RELATED [ChEBI] synonym: "Antibiotic S 7481F1" RELATED [ChemIDplus] synonym: "Ciclosporin" RELATED [KEGG_COMPOUND] synonym: "ciclosporin" RELATED INN [KEGG_DRUG] synonym: "ciclosporina" RELATED INN [ChemIDplus] synonym: "ciclosporine" RELATED INN [ChemIDplus] synonym: "ciclosporinum" RELATED INN [ChemIDplus] synonym: "Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)" RELATED [ChemIDplus] synonym: "Cyclosporin A" EXACT [KEGG_COMPOUND] synonym: "cyclosporin A" EXACT [UniProt] synonym: "Cyclosporine" RELATED [ChemIDplus] synonym: "Cyclosporine" RELATED [KEGG_COMPOUND] synonym: "Gengraf" RELATED BRAND_NAME [DrugBank] synonym: "Neoral" RELATED BRAND_NAME [DrugBank] synonym: "Sandimmune" RELATED BRAND_NAME [DrugBank] xref: Beilstein:3647785 {source="Beilstein"} xref: CAS:59865-13-3 {source="ChemIDplus"} xref: CAS:59865-13-3 {source="KEGG COMPOUND"} xref: Chemspider:4447449 xref: Drug_Central:760 {source="DrugCentral"} xref: DrugBank:DB00091 xref: HMDB:HMDB0250682 xref: KEGG:C05086 xref: KEGG:D00184 xref: KNApSAcK:C00001517 xref: LINCS:LSM-1703 xref: LIPID_MAPS_instance:LMPK14000003 {source="LIPID MAPS"} xref: MetaCyc:CPD-20532 xref: Patent:US4117118 xref: PMID:11058832 {source="Europe PMC"} xref: PMID:11069928 {source="Europe PMC"} xref: PMID:11079273 {source="Europe PMC"} xref: PMID:11080188 {source="Europe PMC"} xref: PMID:11238591 {source="Europe PMC"} xref: PMID:11256490 {source="Europe PMC"} xref: PMID:11278005 {source="Europe PMC"} xref: PMID:11315347 {source="Europe PMC"} xref: PMID:11370709 {source="Europe PMC"} xref: PMID:11406057 {source="Europe PMC"} xref: PMID:11426833 {source="Europe PMC"} xref: PMID:11442023 {source="Europe PMC"} xref: PMID:11481617 {source="Europe PMC"} xref: PMID:11493684 {source="Europe PMC"} xref: PMID:11529914 {source="Europe PMC"} xref: PMID:11557554 {source="Europe PMC"} xref: PMID:11564166 {source="Europe PMC"} xref: PMID:11676831 {source="Europe PMC"} xref: PMID:11870366 {source="Europe PMC"} xref: PMID:12021257 {source="Europe PMC"} xref: PMID:12050171 {source="Europe PMC"} xref: PMID:12603598 {source="Europe PMC"} xref: PMID:12761440 {source="Europe PMC"} xref: PMID:12929192 {source="Europe PMC"} xref: PMID:12950728 {source="Europe PMC"} xref: PMID:14521916 {source="Europe PMC"} xref: PMID:14621732 {source="Europe PMC"} xref: PMID:14638917 {source="Europe PMC"} xref: PMID:14672695 {source="Europe PMC"} xref: PMID:14682659 {source="Europe PMC"} xref: PMID:14743390 {source="Europe PMC"} xref: PMID:15030555 {source="Europe PMC"} xref: PMID:15175101 {source="Europe PMC"} xref: PMID:15210365 {source="Europe PMC"} xref: PMID:15306697 {source="Europe PMC"} xref: PMID:15383526 {source="Europe PMC"} xref: PMID:15541012 {source="Europe PMC"} xref: PMID:15613074 {source="Europe PMC"} xref: PMID:15626898 {source="Europe PMC"} xref: PMID:15657176 {source="Europe PMC"} xref: PMID:1566062 {source="Europe PMC"} xref: PMID:15711594 {source="Europe PMC"} xref: PMID:15811524 {source="Europe PMC"} xref: PMID:15962181 {source="Europe PMC"} xref: PMID:16372476 {source="Europe PMC"} xref: PMID:16404634 {source="Europe PMC"} xref: PMID:16724420 {source="Europe PMC"} xref: PMID:16801218 {source="Europe PMC"} xref: PMID:16898534 {source="Europe PMC"} xref: PMID:17032751 {source="Europe PMC"} xref: PMID:17083576 {source="Europe PMC"} xref: PMID:17117422 {source="Europe PMC"} xref: PMID:17192032 {source="Europe PMC"} xref: PMID:17220244 {source="Europe PMC"} xref: PMID:17229932 {source="Europe PMC"} xref: PMID:17265451 {source="Europe PMC"} xref: PMID:17446460 {source="Europe PMC"} xref: PMID:17603747 {source="Europe PMC"} xref: PMID:18076075 {source="Europe PMC"} xref: PMID:18171316 {source="Europe PMC"} xref: PMID:18191430 {source="Europe PMC"} xref: PMID:18217899 {source="Europe PMC"} xref: PMID:18259730 {source="Europe PMC"} xref: PMID:18299432 {source="Europe PMC"} xref: PMID:18359899 {source="Europe PMC"} xref: PMID:18583716 {source="Europe PMC"} xref: PMID:18597363 {source="Europe PMC"} xref: PMID:18790203 {source="Europe PMC"} xref: PMID:18818682 {source="Europe PMC"} xref: PMID:18931077 {source="Europe PMC"} xref: PMID:18975184 {source="Europe PMC"} xref: PMID:19282398 {source="Europe PMC"} xref: PMID:19589783 {source="Europe PMC"} xref: PMID:21752960 {source="Europe PMC"} xref: PMID:23620378 {source="Europe PMC"} xref: PMID:24134630 {source="Europe PMC"} xref: PMID:31144214 {source="Europe PMC"} xref: PMID:34561200 {source="Europe PMC"} xref: PMID:34561814 {source="Europe PMC"} xref: Reaxys:3647785 {source="Reaxys"} xref: VSDB:1765 xref: Wikipedia:Ciclosporin is_a: CHEBI:24613 ! homodetic cyclic peptide relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:35842 ! has role antirheumatic drug relationship: RO:0000087 CHEBI:37153 ! has role EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor relationship: RO:0000087 CHEBI:49167 ! has role anti-asthmatic drug relationship: RO:0000087 CHEBI:50177 ! has role dermatologic drug relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C62H111N11O12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PMATZTZNYRCHOR-CGLBZJNRSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1202.61120" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1201.84137" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\\C=C\\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C" xsd:string [Term] id: CHEBI:404903 name: ertapenem namespace: chebi_ontology alt_id: CHEBI:471574 def: "Meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract." [] subset: 3_STAR synonym: "(1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid" RELATED [ChEBI] synonym: "(4R,5S,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "(4R,5S,6S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "ERTAPENEM" EXACT [ChEMBL] synonym: "ertapenem" RELATED INN [KEGG_DRUG] xref: Beilstein:9025520 {source="Beilstein"} xref: CAS:153832-46-3 {source="KEGG DRUG"} xref: CAS:153832-46-3 {source="ChemIDplus"} xref: Drug_Central:1046 {source="DrugCentral"} xref: DrugBank:DB00303 xref: KEGG:D07908 xref: Patent:US5478820 xref: Patent:WO9315078 xref: Wikipedia:Ertapenem is_a: CHEBI:46634 ! carbapenemcarboxylic acid is_a: CHEBI:46770 ! pyrrolidinecarboxamide relationship: is_conjugate_acid_of CHEBI:60071 ! ertapenem(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H25N3O7S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H25N3O7S/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32)/t9-,10-,13+,14+,15-,16-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JUZNIMUFDBIJCM-ANEDZVCMSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "475.51500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "475.14132" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(CN[C@@]([H])(C1)C(=O)Nc1cccc(c1)C(O)=O)SC1=C(N2C(=O)[C@]([H])([C@@H](C)O)[C@@]2([H])[C@H]1C)C(O)=O" xsd:string [Term] id: CHEBI:40909 name: azoxystrobin namespace: chebi_ontology def: "An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture." [] subset: 3_STAR synonym: "(alphaE)-2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-alpha-(methoxymethylene) benzeneacetic acid methyl ester" RELATED [ChEBI] synonym: "methyl (2E)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyprop-2-enoate" EXACT IUPAC_NAME [IUPAC] synonym: "methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylate" RELATED [ChEBI] xref: Beilstein:8350244 {source="Beilstein"} xref: CAS:131860-33-8 {source="KEGG COMPOUND"} xref: CAS:131860-33-8 {source="ChemIDplus"} xref: KEGG:C18558 xref: Patent:EP382375 xref: Patent:US5395837 xref: PDBeChem:AZO xref: Pesticides:azoxystrobin {source="Alan Wood's Pesticides"} xref: PMID:20818521 {source="Europe PMC"} xref: PMID:21153804 {source="Europe PMC"} xref: PMID:21671616 {source="Europe PMC"} xref: PMID:21777591 {source="Europe PMC"} xref: PMID:21884765 {source="Europe PMC"} xref: PMID:22092932 {source="Europe PMC"} xref: PMID:22224459 {source="Europe PMC"} xref: PMID:22278367 {source="Europe PMC"} xref: PMID:24125711 {source="Europe PMC"} xref: PMID:24405376 {source="Europe PMC"} xref: PMID:24700092 {source="Europe PMC"} xref: PMID:24726979 {source="Europe PMC"} xref: PMID:25011117 {source="Europe PMC"} xref: PMID:25090100 {source="Europe PMC"} xref: PMID:25196149 {source="Europe PMC"} xref: PPDB:54 xref: Reaxys:8350244 {source="Reaxys"} xref: Wikipedia:Azoxystrobin is_a: CHEBI:18379 ! nitrile is_a: CHEBI:47985 ! enol ether is_a: CHEBI:48535 ! aryloxypyrimidine is_a: CHEBI:86484 ! methoxyacrylate strobilurin antifungal agent relationship: RO:0000087 CHEBI:141153 ! has role quinone outside inhibitor relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H17N3O5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H17N3O5/c1-27-13-17(22(26)28-2)16-8-4-6-10-19(16)30-21-11-20(24-14-25-21)29-18-9-5-3-7-15(18)12-23/h3-11,13-14H,1-2H3/b17-13+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WFDXOXNFNRHQEC-GHRIWEEISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "403.38750" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "403.11682" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO\\C=C(\\C(=O)OC)c1ccccc1Oc1cc(Oc2ccccc2C#N)ncn1" xsd:string [Term] id: CHEBI:41032 name: 5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazol-1-ium namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:81783 ! tricyclazole [Term] id: CHEBI:41275 name: 1H-benzimidazole namespace: chebi_ontology alt_id: CHEBI:3028 alt_id: CHEBI:41272 def: "The 1H-tautomer of benzimidazole." [] subset: 3_STAR synonym: "1,3-benzodiazole" RELATED [ChemIDplus] synonym: "1,3-diazaindene" RELATED [ChemIDplus] synonym: "1H-benzimidazole" EXACT IUPAC_NAME [IUPAC] synonym: "azindole" RELATED [ChemIDplus] synonym: "BENZIMIDAZOLE" RELATED [PDBeChem] synonym: "Benzimidazole" RELATED [KEGG_COMPOUND] synonym: "benzimidazole" RELATED [IUPAC] synonym: "benzoglyoxaline" RELATED [ChemIDplus] synonym: "Hbim" RELATED [IUPAC] synonym: "Hbzim" RELATED [IUPAC] synonym: "o-benzimidazole" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:109682 {source="Beilstein"} xref: CAS:51-17-2 {source="NIST Chemistry WebBook"} xref: CAS:51-17-2 {source="ChemIDplus"} xref: CAS:51-17-2 {source="KEGG COMPOUND"} xref: DrugBank:DB02962 xref: Gmelin:3106 {source="Gmelin"} xref: KEGG:C02009 xref: MetaCyc:BENZIMIDAZOLE xref: PDBeChem:BZI xref: PMID:24152176 {source="Europe PMC"} xref: PMID:8070089 {source="Europe PMC"} xref: Reaxys:109682 {source="Reaxys"} xref: Wikipedia:Benzimidazole is_a: CHEBI:36622 ! benzimidazole is_a: CHEBI:38180 ! polycyclic heteroarene relationship: is_conjugate_acid_of CHEBI:33173 ! benzimidazolide relationship: is_tautomer_of CHEBI:36623 ! 4H-benzimidazole relationship: is_tautomer_of CHEBI:36639 ! 2H-benzimidazole relationship: is_tautomer_of CHEBI:36641 ! 3aH-benzimidazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-5H,(H,8,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HYZJCKYKOHLVJF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "118.13602" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "118.05310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2[nH]cnc2c1" xsd:string [Term] id: CHEBI:41609 name: carbonate namespace: chebi_ontology alt_id: CHEBI:29201 alt_id: CHEBI:41605 subset: 3_STAR synonym: "[CO3](2-)" RELATED [IUPAC] synonym: "carbonate" EXACT [IUPAC] synonym: "CARBONATE ION" RELATED [PDBeChem] synonym: "CO3(2-)" RELATED [ChEBI] synonym: "Karbonat" RELATED [ChEBI] synonym: "trioxidocarbonate(2-)" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:3600898 {source="Beilstein"} xref: CAS:3812-32-6 {source="ChemIDplus"} xref: Gmelin:1559 {source="Gmelin"} xref: PDBeChem:CO3 is_a: CHEBI:35604 ! carbon oxoanion relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.00890" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.98584" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([O-])=O" xsd:string [Term] id: CHEBI:4167 name: D-glucopyranose namespace: chebi_ontology def: "A glucopyranose having D-configuration." [] subset: 3_STAR synonym: "D-Glc" RELATED [ChEBI] synonym: "D-Glcp" RELATED [ChEBI] synonym: "D-glucopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "D-Glucose" RELATED [KEGG_COMPOUND] synonym: "D-glucose" RELATED [UniProt] synonym: "Dextrose" RELATED [KEGG_COMPOUND] synonym: "Glc-OH" RELATED [ChEBI] synonym: "Glucose" RELATED [KEGG_COMPOUND] synonym: "glucose" RELATED [ChEBI] synonym: "Grape sugar" RELATED [KEGG_COMPOUND] synonym: "WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/" RELATED [GlyTouCan] xref: Beilstein:1281604 {source="Beilstein"} xref: CAS:2280-44-6 {source="ChemIDplus"} xref: GlyGen:G15021LG xref: GlyTouCan:G15021LG xref: Gmelin:83256 {source="Gmelin"} xref: HMDB:HMDB0000122 xref: KEGG:C00031 xref: KEGG:D00009 xref: KNApSAcK:C00001122 xref: MetaCyc:D-Glucose xref: PMID:15987845 {source="Europe PMC"} xref: PMID:16901854 {source="Europe PMC"} xref: PMID:17336832 {source="Europe PMC"} xref: PMID:17439666 {source="Europe PMC"} xref: PMID:17928662 {source="Europe PMC"} xref: PMID:19913595 {source="Europe PMC"} xref: PMID:26812026 {source="Europe PMC"} xref: PMID:32619908 {source="Europe PMC"} xref: PMID:7524207 {source="Europe PMC"} xref: PMID:9140037 {source="Europe PMC"} xref: PMID:9501190 {source="Europe PMC"} xref: PMID:9506998 {source="Europe PMC"} xref: PMID:9545565 {source="Europe PMC"} xref: Reaxys:1281604 {source="Reaxys"} xref: Wikipedia:Glucose is_a: CHEBI:17634 ! D-glucose is_a: CHEBI:37661 ! glucopyranose relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-GASJEMHNSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:417636 name: 4-\{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl\}-thiazol-2-yl-ammonium namespace: chebi_ontology subset: 2_STAR is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:33575 ! carboxylic acid relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:4194 name: D-hexose namespace: chebi_ontology def: "A hexose that has D-configuration at position 5." [] subset: 3_STAR synonym: "D-hexopyranose" EXACT IUPAC_NAME [IUPAC] synonym: "D-Hexose" EXACT [KEGG_COMPOUND] synonym: "D-hexose" EXACT [UniProt] synonym: "D-hexoses" RELATED [ChEBI] xref: KEGG:C00738 is_a: CHEBI:18133 ! hexose property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string [Term] id: CHEBI:41948 name: eflornithine namespace: chebi_ontology alt_id: CHEBI:41946 alt_id: CHEBI:4761 def: "A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2." [] subset: 3_STAR synonym: "2,5-diamino-2-(difluoromethyl)pentanoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "2-(difluoromethyl)ornithine" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-(Difluoromethyl)-DL-ornithine" RELATED [DrugCentral] synonym: "ALPHA-DIFLUOROMETHYLORNITHINE" RELATED [PDBeChem] synonym: "alpha-difluoromethylornithine" RELATED [ChemIDplus] synonym: "DFMO" RELATED [ChemIDplus] synonym: "DL-Ornithine, 2-(difluoromethyl)-" RELATED [KEGG_COMPOUND] synonym: "Eflornithine" EXACT [KEGG_COMPOUND] xref: Beilstein:2250529 {source="ChemIDplus"} xref: CAS:67037-37-0 {source="ChemIDplus"} xref: CAS:67037-37-0 {source="KEGG COMPOUND"} xref: CAS:70052-12-9 {source="ChemIDplus"} xref: Drug_Central:990 {source="DrugCentral"} xref: DrugBank:DB03856 xref: KEGG:C07997 xref: KEGG:D07883 xref: PDBeChem:DMO xref: PMID:16541214 {source="Europe PMC"} xref: PMID:23771434 {source="Europe PMC"} xref: PMID:24144414 {source="Europe PMC"} xref: Reaxys:2250529 {source="Reaxys"} xref: Wikipedia:Eflornithine is_a: CHEBI:24068 ! fluoroamino acid is_a: CHEBI:33704 ! alpha-amino acid relationship: has_functional_parent CHEBI:18257 ! ornithine relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12F2N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VLCYCQAOQCDTCN-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "182.16850" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "182.08668" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCCC(N)(C(F)F)C(O)=O" xsd:string [Term] id: CHEBI:42266 name: ethane namespace: chebi_ontology alt_id: CHEBI:23975 alt_id: CHEBI:42260 def: "An alkane comprising of two carbon atoms." [] subset: 3_STAR synonym: "Aethan" RELATED [ChEBI] synonym: "bimethyl" RELATED [NIST_Chemistry_WebBook] synonym: "C2H6" RELATED [ChEBI] synonym: "CH3-CH3" RELATED [IUPAC] synonym: "dimethyl" RELATED [NIST_Chemistry_WebBook] synonym: "Ethan" RELATED [ChEBI] synonym: "ETHANE" EXACT [PDBeChem] synonym: "ethane" EXACT IUPAC_NAME [IUPAC] synonym: "ethyl hydride" RELATED [NIST_Chemistry_WebBook] synonym: "methylmethane" RELATED [NIST_Chemistry_WebBook] synonym: "R-170" RELATED [ChEBI] xref: Beilstein:1730716 {source="Beilstein"} xref: CAS:74-84-0 {source="ChemIDplus"} xref: CAS:74-84-0 {source="NIST Chemistry WebBook"} xref: Gmelin:212 {source="Gmelin"} xref: PMID:12826252 {source="Europe PMC"} xref: PMID:14664856 {source="Europe PMC"} xref: PMID:16236899 {source="Europe PMC"} xref: Reaxys:1730716 {source="Reaxys"} xref: Wikipedia:Ethane is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:18310 ! alkane relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:78433 ! has role refrigerant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H6/c1-2/h1-2H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OTMSDBZUPAUEDD-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "30.06904" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.04695" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC" xsd:string [Term] id: CHEBI:42355 name: erythromycin A namespace: chebi_ontology alt_id: CHEBI:112506 alt_id: CHEBI:23950 alt_id: CHEBI:28672 alt_id: CHEBI:42352 alt_id: CHEBI:4841 alt_id: CHEBI:4843 def: "An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively." [] subset: 3_STAR synonym: "(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-6-[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione" EXACT IUPAC_NAME [IUPAC] synonym: "(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione" RELATED [IUPAC] synonym: "3''-O-demethylerythromycin" RELATED [ChemIDplus] synonym: "Abomacetin" RELATED [KEGG_COMPOUND] synonym: "eritromicina" RELATED INN [ChemIDplus] synonym: "erthromycin" RELATED [ChEBI] synonym: "ERYTHROMYCIN" RELATED [ChEMBL] synonym: "Erythromycin" RELATED [ChEMBL] synonym: "Erythromycin" RELATED [KEGG_COMPOUND] synonym: "erythromycin" EXACT IUPAC_NAME [IUPAC] synonym: "erythromycin" RELATED INN [ChemIDplus] synonym: "ERYTHROMYCIN A" EXACT [PDBeChem] synonym: "Erythromycin A" EXACT [ChEMBL] synonym: "Erythromycin A" EXACT [KEGG_COMPOUND] synonym: "Erythromycin C" RELATED [KEGG_COMPOUND] synonym: "erythromycine" RELATED INN [ChemIDplus] synonym: "erythromycinum" RELATED INN [ChemIDplus] xref: Beilstein:75000 {source="Beilstein"} xref: Beilstein:75279 {source="Beilstein"} xref: CAS:114-07-8 {source="ChemIDplus"} xref: CAS:114-07-8 {source="KEGG COMPOUND"} xref: CAS:1675-02-1 {source="ChemIDplus"} xref: Drug_Central:1048 {source="DrugCentral"} xref: DrugBank:DB00199 xref: KEGG:C01912 xref: KEGG:D00140 xref: LINCS:LSM-3416 xref: LIPID_MAPS_instance:LMPK04000006 {source="LIPID MAPS"} xref: MetaCyc:CPD-13804 xref: Patent:US2823203 xref: PDBeChem:ERY xref: Reaxys:75279 {source="Reaxys"} is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:48923 ! erythromycin relationship: has_functional_parent CHEBI:48848 ! erythronolide A relationship: is_conjugate_base_of CHEBI:64268 ! erythromycin A(1+) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C37H67NO13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ULGZDMOVFRHVEP-RWJQBGPGSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "733.92680" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "733.46124" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O" xsd:string [Term] id: CHEBI:42485 name: formyl group namespace: chebi_ontology alt_id: CHEBI:24089 alt_id: CHEBI:42480 subset: 3_STAR synonym: "-CH(O)" RELATED [IUPAC] synonym: "-CHO" RELATED [IUPAC] synonym: "aldehyde group" EXACT IUPAC_NAME [IUPAC] synonym: "carbaldehyde" EXACT IUPAC_NAME [IUPAC] synonym: "Fo" RELATED [CBN] synonym: "formyl" EXACT IUPAC_NAME [IUPAC] synonym: "FORMYL GROUP" EXACT [PDBeChem] synonym: "H-CO-" RELATED [IUPAC] synonym: "methanoyl" RELATED [IUPAC] xref: PDBeChem:FOR is_a: CHEBI:27207 ! univalent carboacyl group relationship: is_substituent_group_from CHEBI:30751 ! formic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "29.01804" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(*)=O" xsd:string [Term] id: CHEBI:43176 name: hydroxy group namespace: chebi_ontology alt_id: CHEBI:24706 alt_id: CHEBI:43171 subset: 3_STAR synonym: "-OH" RELATED [IUPAC] synonym: "hydroxy" EXACT IUPAC_NAME [IUPAC] synonym: "HYDROXY GROUP" EXACT [PDBeChem] synonym: "hydroxy group" EXACT [UniProt] synonym: "hydroxyl" RELATED [ChEBI] synonym: "hydroxyl group" RELATED [ChEBI] xref: PDBeChem:OH is_a: CHEBI:33246 ! inorganic group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "17.00734" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*O[H]" xsd:string [Term] id: CHEBI:43254 name: (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:38337 ! pyrimidone relationship: is_tautomer_of CHEBI:17568 ! uracil [Term] id: CHEBI:43474 name: hydrogenphosphate namespace: chebi_ontology alt_id: CHEBI:29139 alt_id: CHEBI:43470 def: "A phosphate ion that is the conjugate base of dihydrogenphosphate." [] subset: 3_STAR synonym: "[P(OH)O3](2-)" RELATED [MolBase] synonym: "[PO3(OH)](2-)" RELATED [IUPAC] synonym: "HPO4(2-)" RELATED [IUPAC] synonym: "hydrogen phosphate" RELATED [ChEBI] synonym: "hydrogen(tetraoxidophosphate)(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogenphosphate" EXACT IUPAC_NAME [IUPAC] synonym: "HYDROGENPHOSPHATE ION" RELATED [PDBeChem] synonym: "hydrogentetraoxophosphate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidotrioxidophosphate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "INORGANIC PHOSPHATE GROUP" RELATED [PDBeChem] synonym: "phosphate" RELATED [UniProt] xref: Gmelin:1998 {source="Gmelin"} xref: MolBase:1628 xref: PDBeChem:PI xref: PDBeChem:PO4 is_a: CHEBI:35780 ! phosphate ion is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_acid_of CHEBI:18367 ! phosphate(3-) relationship: is_conjugate_base_of CHEBI:39745 ! dihydrogenphosphate relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "95.97930" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.96234" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OP([O-])([O-])=O" xsd:string [Term] id: CHEBI:43968 name: meropenem namespace: chebi_ontology def: "A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively." [] subset: 3_STAR synonym: "(1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-YLTHIO]-6-[(R)-1-HYDROXYETHYL]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLIC ACID" RELATED [PDBeChem] synonym: "(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "(6S)-2-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-1beta-methyl-2,3-didehydro-1-carbapenam-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Antibiotic SM 7338" RELATED [DrugBank] synonym: "MEPM" RELATED [ChEBI] synonym: "Meropenem" EXACT [ChemIDplus] synonym: "meropenem" RELATED INN [ChEBI] synonym: "meropenem anhydrous" RELATED [ChemIDplus] synonym: "meropenemum" RELATED INN [DrugBank] xref: Beilstein:6826115 {source="Beilstein"} xref: CAS:96036-03-2 {source="ChemIDplus"} xref: Drug_Central:1709 {source="DrugCentral"} xref: DrugBank:DB00760 xref: LINCS:LSM-5208 xref: Patent:EP126587 xref: Patent:US4943569 xref: PDBeChem:MER xref: PMID:10776838 {source="Europe PMC"} xref: PMID:11069213 {source="Europe PMC"} xref: PMID:18611786 {source="Europe PMC"} xref: PMID:18645546 {source="Europe PMC"} xref: PMID:28343819 {source="Europe PMC"} xref: PMID:28371721 {source="Europe PMC"} xref: PMID:28583381 {source="Europe PMC"} xref: PMID:28669829 {source="Europe PMC"} xref: PMID:28677407 {source="Europe PMC"} xref: PMID:7588092 {source="Europe PMC"} xref: Wikipedia:Meropenem is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:46634 ! carbapenemcarboxylic acid is_a: CHEBI:46770 ! pyrrolidinecarboxamide is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H25N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DMJNNHOOLUXYBV-PQTSNVLCSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "383.46300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "383.15149" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O" xsd:string [Term] id: CHEBI:44137 name: tiamulin namespace: chebi_ontology alt_id: CHEBI:29695 def: "A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae." [] subset: 3_STAR synonym: "(3aS,4R,5S,6S,8R,9R,9aR,10R)-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl {[2-(diethylamino)ethyl]sulfanyl}acetate" EXACT IUPAC_NAME [IUPAC] synonym: "tiamulin" RELATED INN [WHO_MedNet] synonym: "tiamulina" RELATED INN [WHO_MedNet] synonym: "tiamuline" RELATED INN [WHO_MedNet] synonym: "tiamulinum" RELATED INN [WHO_MedNet] xref: CAS:55297-95-5 {source="ChemIDplus"} xref: CAS:55297-95-5 {source="KEGG COMPOUND"} xref: KEGG:C12065 xref: KEGG:D06127 xref: Patent:DE2248237 xref: Patent:US3919290 xref: PDBeChem:MUL xref: PMID:15013817 {source="Europe PMC"} xref: PMID:16253666 {source="Europe PMC"} xref: PMID:25592328 {source="Europe PMC"} xref: PMID:3170319 {source="Europe PMC"} xref: PMID:3686511 {source="Europe PMC"} xref: Reaxys:7348837 {source="Reaxys"} xref: Wikipedia:Tiamulin is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:38032 ! carbotricyclic compound is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:52557 ! tetracyclic diterpenoid is_a: CHEBI:72588 ! semisynthetic derivative relationship: has_functional_parent CHEBI:8269 ! Pleuromutilin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C28H47NO4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UURAUHCOJAIIRQ-QGLSALSOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "493.74200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "493.32258" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@]23CCC(=O)[C@H]2[C@@]1(C)[C@H](C)CC3" xsd:string [Term] id: CHEBI:44976 name: phosphonic acid namespace: chebi_ontology alt_id: CHEBI:26067 def: "A phosphorus oxoacid that consists of a single pentavalent phosphorus covalently bound via single bonds to a single hydrogen and two hydroxy groups and via a double bond to an oxygen. The parent of the class of phosphonic acids." [] subset: 3_STAR synonym: "(HO)2HPO" RELATED [NIST_Chemistry_WebBook] synonym: "[PHO(OH)2]" RELATED [IUPAC] synonym: "dihydrogen hydridotrioxophosphate(2-)" EXACT IUPAC_NAME [IUPAC] synonym: "H2PHO3" RELATED [IUPAC] synonym: "H3PO3" RELATED [ChEBI] synonym: "HPO(OH)2" RELATED [IUPAC] synonym: "hydridodihydroxidooxidophosphorus" EXACT IUPAC_NAME [IUPAC] synonym: "hydridotrioxophosphoric(2-) acid" EXACT IUPAC_NAME [IUPAC] synonym: "Phosphite" RELATED [KEGG_COMPOUND] synonym: "Phosphonate" RELATED [KEGG_COMPOUND] synonym: "Phosphonic acid" EXACT [KEGG_COMPOUND] synonym: "phosphonic acid" EXACT [ChEBI] synonym: "Phosphonsaeure" RELATED [ChEBI] xref: CAS:13598-36-2 {source="NIST Chemistry WebBook"} xref: CAS:13598-36-2 {source="ChemIDplus"} xref: CAS:13598-36-2 {source="KEGG COMPOUND"} xref: Gmelin:1619 {source="Gmelin"} xref: KEGG:C06701 xref: PDBeChem:PHS xref: Reaxys:1209272 {source="Reaxys"} xref: Wikipedia:Phosphonic_acid is_a: CHEBI:26069 ! phosphonic acids is_a: CHEBI:33457 ! phosphorus oxoacid relationship: is_conjugate_acid_of CHEBI:33462 ! phosphonate(1-) relationship: is_tautomer_of CHEBI:36361 ! phosphorous acid relationship: RO:0000087 CHEBI:24127 ! has role fungicide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H3O3P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O3P/c1-4(2)3/h4H,(H2,1,2,3)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ABLZXFCXXLZCGV-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "81.99580" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.98198" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OP(O)=O" xsd:string [Term] id: CHEBI:45064 name: phosphite(3-) namespace: chebi_ontology alt_id: CHEBI:29197 alt_id: CHEBI:45060 def: "A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid." [] subset: 3_STAR synonym: "[PO3](3-)" RELATED [IUPAC] synonym: "Phosphit" RELATED [ChEBI] synonym: "phosphite" RELATED [IUPAC] synonym: "PHOSPHITE ION" RELATED [PDBeChem] synonym: "PO3(3-)" RELATED [IUPAC] synonym: "trioxidophosphate(3-)" EXACT IUPAC_NAME [IUPAC] synonym: "trioxophosphate(3-)" EXACT IUPAC_NAME [IUPAC] synonym: "trioxophosphate(III)" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:68617 {source="Gmelin"} xref: PDBeChem:PO3 is_a: CHEBI:26045 ! phosphite ion is_a: CHEBI:79387 ! trivalent inorganic anion relationship: is_conjugate_base_of CHEBI:29259 ! hydrogenphosphite property_value: http://purl.obolibrary.org/obo/chebi/charge "-3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O3P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/O3P/c1-4(2)3/q-3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AQSJGOWTSHOLKH-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "78.97196" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "78.96015" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]P([O-])[O-]" xsd:string [Term] id: CHEBI:45081 name: pentamidine namespace: chebi_ontology alt_id: CHEBI:45077 alt_id: CHEBI:7976 def: "A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease." [] subset: 3_STAR synonym: "1,5-bis(4-amidinophenoxy)pentane" RELATED [ChEBI] synonym: "4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide" RELATED [ChemIDplus] synonym: "4,4'-(pentamethylenedioxy)dibenzamidine" RELATED [ChemIDplus] synonym: "4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide" EXACT IUPAC_NAME [IUPAC] synonym: "4,4'-Diamidinodiphenoxypentane" RELATED [DrugBank] synonym: "p,p'-(pentamethylenedioxy)dibenzamidine" RELATED [ChemIDplus] synonym: "pentamidin" RELATED [DrugCentral] synonym: "Pentamidine" EXACT [KEGG_COMPOUND] synonym: "pentamidine" RELATED INN [KEGG_DRUG] xref: Beilstein:3159790 {source="ChemIDplus"} xref: CAS:100-33-4 {source="KEGG COMPOUND"} xref: CAS:100-33-4 {source="ChemIDplus"} xref: Drug_Central:2090 {source="DrugCentral"} xref: DrugBank:DB00738 xref: HMDB:HMDB0014876 xref: KEGG:C07420 xref: KEGG:D08333 xref: LINCS:LSM-4540 xref: Patent:EP975608 xref: Patent:GB507565 xref: Patent:US2006235001 xref: Patent:US2008167296 xref: Patent:US2008214569 xref: Patent:US2394003 xref: Patent:US7115665 xref: PDBeChem:PNT xref: PMID:10415905 {source="Europe PMC"} xref: PMID:10917591 {source="Europe PMC"} xref: PMID:11438428 {source="Europe PMC"} xref: PMID:11584934 {source="Europe PMC"} xref: PMID:14603035 {source="Europe PMC"} xref: PMID:15711592 {source="Europe PMC"} xref: PMID:18346045 {source="Europe PMC"} xref: PMID:18971316 {source="Europe PMC"} xref: PMID:19966562 {source="Europe PMC"} xref: PMID:20144237 {source="Europe PMC"} xref: PMID:20599360 {source="Europe PMC"} xref: PMID:22046004 {source="Europe PMC"} xref: PMID:22093811 {source="Europe PMC"} xref: PMID:22200378 {source="Europe PMC"} xref: PMID:22327112 {source="Europe PMC"} xref: PMID:26052915 {source="Europe PMC"} xref: PMID:26117647 {source="Europe PMC"} xref: PMID:26295040 {source="Europe PMC"} xref: PMID:26344166 {source="Europe PMC"} xref: PMID:26418240 {source="Europe PMC"} xref: PMID:26431253 {source="Europe PMC"} xref: PMID:26515653 {source="Europe PMC"} xref: PMID:26606757 {source="Europe PMC"} xref: PMID:26648589 {source="Europe PMC"} xref: PMID:26734860 {source="Europe PMC"} xref: PMID:26824946 {source="Europe PMC"} xref: PMID:26828608 {source="Europe PMC"} xref: PMID:26882015 {source="Europe PMC"} xref: PMID:26903605 {source="Europe PMC"} xref: PMID:26938448 {source="Europe PMC"} xref: PMID:27011917 {source="Europe PMC"} xref: PMID:27135970 {source="Europe PMC"} xref: PMID:27164533 {source="Europe PMC"} xref: PMID:27214074 {source="Europe PMC"} xref: PMID:27297108 {source="Europe PMC"} xref: PMID:27353022 {source="Europe PMC"} xref: PMID:27357655 {source="Europe PMC"} xref: PMID:27600039 {source="Europe PMC"} xref: PMID:27729250 {source="Europe PMC"} xref: PMID:28074607 {source="Europe PMC"} xref: PMID:28167598 {source="Europe PMC"} xref: PMID:28263303 {source="Europe PMC"} xref: PMID:7542607 {source="Europe PMC"} xref: PMID:7690919 {source="Europe PMC"} xref: PMID:8841838 {source="Europe PMC"} xref: Reaxys:3159790 {source="Reaxys"} xref: Wikipedia:Pentamidine is_a: CHEBI:35359 ! carboxamidine is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:46786 ! diether relationship: is_conjugate_base_of CHEBI:64383 ! pentamidinium(2+) relationship: RO:0000087 CHEBI:130181 ! has role calmodulin antagonist relationship: RO:0000087 CHEBI:136651 ! has role S100 calcium-binding protein B inhibitor relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug relationship: RO:0000087 CHEBI:60643 ! has role NMDA receptor antagonist relationship: RO:0000087 CHEBI:63673 ! has role chemokine receptor 5 antagonist relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent relationship: RO:0000087 CHEBI:76395 ! has role EC 2.3.1.48 (histone acetyltransferase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H24N4O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XDRYMKDFEDOLFX-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "340.420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "340.18993" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(CCCOC1=CC=C(C=C1)C(N)=N)COC2=CC=C(C=C2)C(N)=N" xsd:string [Term] id: CHEBI:4511 name: dicloxacillin namespace: chebi_ontology def: "A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6beta-{[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carboxamido}-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "dicloxacilina" RELATED INN [DrugBank] synonym: "Dicloxacillin" EXACT [KEGG_COMPOUND] synonym: "dicloxacilline" RELATED INN [DrugBank] synonym: "dicloxacillinum" RELATED INN [DrugBank] xref: Beilstein:1233662 {source="Beilstein"} xref: CAS:3116-76-5 {source="KEGG COMPOUND"} xref: Drug_Central:866 {source="DrugCentral"} xref: DrugBank:DB00485 xref: KEGG:C06950 xref: KEGG:D02348 xref: LINCS:LSM-5234 xref: Patent:GB978299 xref: Patent:US3239507 xref: PMID:26962156 {source="Europe PMC"} xref: PMID:28721014 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:29105855 {source="Europe PMC"} xref: PMID:29253094 {source="Europe PMC"} xref: PMID:29504695 {source="Europe PMC"} xref: Reaxys:1233662 {source="Reaxys"} xref: Wikipedia:Dicloxacillin is_a: CHEBI:17334 ! penicillin is_a: CHEBI:23697 ! dichlorobenzene relationship: is_conjugate_acid_of CHEBI:52017 ! dicloxacillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H17Cl2N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YFAGHNZHGGCZAX-JKIFEVAISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "470.32600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "469.02660" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1c(Cl)cccc1Cl)C(O)=O" xsd:string [Term] id: CHEBI:4520 name: diethofencarb namespace: chebi_ontology def: "A carbamate ester that is the isopropyl ester of (3,4-diethoxyphenyl)carbamic acid. A fungicide with strong activity against Botrytis cinerea and benzimidazole-resistant strains of Botryis spp." [] subset: 3_STAR synonym: "1-Methylethyl (3,4-diethoxyphenyl)carbamate" RELATED [ChemIDplus] synonym: "1-methylethyl N-(3,4-diethoxyphenyl)carbamate" RELATED [Alan_Wood's_Pesticides] synonym: "isopropyl (3,4-diethoxyphenyl)carbamate" RELATED [IUPAC] synonym: "Isopropyl 3,4-diethoxycarbanilate" RELATED [ChemIDplus] synonym: "propan-2-yl (3,4-diethoxyphenyl)carbamate" EXACT IUPAC_NAME [IUPAC] xref: CAS:87130-20-9 {source="ChemIDplus"} xref: CAS:87130-20-9 {source="NIST Chemistry WebBook"} xref: CAS:87130-20-9 {source="KEGG COMPOUND"} xref: KEGG:C11077 xref: Pesticides:diethofencarb {source="Alan Wood's Pesticides"} xref: PMID:21174194 {source="Europe PMC"} xref: PMID:21763813 {source="Europe PMC"} xref: PMID:22921656 {source="Europe PMC"} xref: PMID:23404952 {source="Europe PMC"} xref: PMID:23597988 {source="Europe PMC"} xref: PMID:23760810 {source="Europe PMC"} xref: PMID:24679760 {source="Europe PMC"} xref: PMID:24817605 {source="Europe PMC"} xref: PMID:24861738 {source="Europe PMC"} xref: PMID:24973804 {source="Europe PMC"} xref: PPDB:228 xref: Reaxys:8393454 {source="Reaxys"} is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:87066 ! carbanilate fungicide relationship: has_functional_parent CHEBI:17296 ! aniline relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H21NO4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H21NO4/c1-5-17-12-8-7-11(9-13(12)18-6-2)15-14(16)19-10(3)4/h7-10H,5-6H2,1-4H3,(H,15,16)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LNJNFVJKDJYTEU-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "267.32080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "267.14706" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCOc1ccc(NC(=O)OC(C)C)cc1OCC" xsd:string [Term] id: CHEBI:45285 name: pyrazinecarboxamide namespace: chebi_ontology alt_id: CHEBI:45281 alt_id: CHEBI:8656 def: "A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis." [] subset: 3_STAR synonym: "2-carbamylpyrazine" RELATED [ChemIDplus] synonym: "2-pyrazinecarboxamide" RELATED [ChemIDplus] synonym: "pyrazinamida" RELATED INN [WHO_MedNet] synonym: "Pyrazinamide" RELATED [KEGG_COMPOUND] synonym: "pyrazinamide" RELATED [UniProt] synonym: "pyrazinamide" RELATED INN [WHO_MedNet] synonym: "pyrazinamidum" RELATED INN [WHO_MedNet] synonym: "pyrazine carboxamide" RELATED [NIST_Chemistry_WebBook] synonym: "PYRAZINE-2-CARBOXAMIDE" RELATED [PDBeChem] synonym: "pyrazine-2-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "pyrazineamide" RELATED [NIST_Chemistry_WebBook] synonym: "Pyrazinoic acid amide" RELATED [KEGG_COMPOUND] xref: Beilstein:112306 {source="Beilstein"} xref: CAS:98-96-4 {source="ChemIDplus"} xref: CAS:98-96-4 {source="NIST Chemistry WebBook"} xref: CAS:98-96-4 {source="KEGG COMPOUND"} xref: Drug_Central:2328 {source="DrugCentral"} xref: DrugBank:DB00339 xref: Gmelin:279021 {source="Gmelin"} xref: HMDB:HMDB0014483 xref: KEGG:C01956 xref: KEGG:D00144 xref: LINCS:LSM-5425 xref: PDBeChem:PZA xref: PMID:14977529 {source="Europe PMC"} xref: PMID:18517115 {source="Europe PMC"} xref: PMID:18604033 {source="Europe PMC"} xref: Reaxys:112306 {source="Reaxys"} xref: Wikipedia:Pyrazinamide is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:38314 ! pyrazines is_a: CHEBI:83628 ! N-acylammonia relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:50266 ! has role prodrug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H5N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IPEHBUMCGVEMRF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "123.11282" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "123.04326" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)c1cnccn1" xsd:string [Term] id: CHEBI:45367 name: rifabutin namespace: chebi_ontology alt_id: CHEBI:45364 alt_id: CHEBI:8857 subset: 3_STAR synonym: "1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV" RELATED [ChemIDplus] synonym: "4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S" RELATED [ChemIDplus] synonym: "4-N-isobutylspiropiperidylrifamycin S" RELATED [ChemIDplus] synonym: "Mycobutin (TN)" RELATED [KEGG_DRUG] synonym: "Rifabutin" EXACT [KEGG_DRUG] synonym: "Rifabutin" EXACT [KEGG_COMPOUND] xref: CAS:72559-06-9 {source="ChemIDplus"} xref: CAS:72559-06-9 {source="KEGG COMPOUND"} xref: Drug_Central:2376 {source="DrugCentral"} xref: DrugBank:DB00615 xref: KEGG:C07235 xref: KEGG:D00424 xref: KNApSAcK:C00027872 xref: Wikipedia:Rifabutin is_a: CHEBI:26580 ! rifamycins relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C46H62N4O11" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ATEBXHFBFRCZMA-VXTBVIBXSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "847.00484" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "846.44151" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C)c(O)c4C(=O)C(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC5(CCN(CC5)CC(C)C)N=C1c4c3C2=O" xsd:string [Term] id: CHEBI:45373 name: sulfanilamide namespace: chebi_ontology alt_id: CHEBI:45370 alt_id: CHEBI:9333 def: "A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position." [] subset: 3_STAR synonym: "4-aminobenzene sulfonic acid amide" RELATED [ChEBI] synonym: "4-aminobenzenesulfonamide" EXACT IUPAC_NAME [IUPAC] synonym: "4-azanylbenzenesulfonamide" RELATED [IUPAC] synonym: "p-aminobenzenesulfamide" RELATED [NIST_Chemistry_WebBook] synonym: "p-aminobenzenesulfonamide" RELATED [NIST_Chemistry_WebBook] synonym: "para-aminobenzenesulfonamide" RELATED [ChEBI] synonym: "Prontosil album" RELATED [KEGG_COMPOUND] synonym: "SA" RELATED [ChEBI] synonym: "Streptocide" RELATED [NIST_Chemistry_WebBook] synonym: "Sulfamine" RELATED [KEGG_COMPOUND] synonym: "sulfamine" RELATED [NIST_Chemistry_WebBook] synonym: "SULFANILAMIDE" EXACT [PDBeChem] synonym: "Sulfanilamide" EXACT [KEGG_COMPOUND] synonym: "sulphanilamide" RELATED [ChEBI] xref: Beilstein:511852 {source="Beilstein"} xref: CAS:63-74-1 {source="NIST Chemistry WebBook"} xref: CAS:63-74-1 {source="KEGG COMPOUND"} xref: CAS:63-74-1 {source="ChemIDplus"} xref: Drug_Central:2521 {source="DrugCentral"} xref: DrugBank:DB00259 xref: Gmelin:83068 {source="Gmelin"} xref: HMDB:HMDB0014404 xref: KEGG:C07458 xref: KEGG:D08543 xref: LINCS:LSM-6524 xref: PDBeChem:SAN xref: PMID:22214209 {source="Europe PMC"} xref: PMID:22342371 {source="Europe PMC"} xref: PMID:22974493 {source="Europe PMC"} xref: PMID:23061287 {source="Europe PMC"} xref: PMID:23065453 {source="Europe PMC"} xref: PMID:23122138 {source="Europe PMC"} xref: PMID:23294218 {source="Europe PMC"} xref: PMID:23476893 {source="Europe PMC"} xref: PMID:23561569 {source="Europe PMC"} xref: PMID:2420897 {source="Europe PMC"} xref: PMID:9639594 {source="Europe PMC"} xref: Reaxys:511852 {source="Reaxys"} xref: VSDB:1924 xref: Wikipedia:Sulfanilamide is_a: CHEBI:48975 ! substituted aniline is_a: CHEBI:87228 ! sulfonamide antibiotic relationship: RO:0000087 CHEBI:23018 ! has role EC 4.2.1.1 (carbonic anhydrase) inhibitor relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H8N2O2S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FDDDEECHVMSUSB-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "172.20600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "172.03065" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ccc(cc1)S(N)(=O)=O" xsd:string [Term] id: CHEBI:45599 name: dodecyl hydrogen sulfate namespace: chebi_ontology alt_id: CHEBI:32953 alt_id: CHEBI:45595 subset: 3_STAR synonym: "dodecyl hydrogen sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "DODECYL SULFATE" RELATED [PDBeChem] synonym: "lauryl sulfuric acid" RELATED [ChemIDplus] synonym: "monododecyl hydrogen sulfate" RELATED [ChemIDplus] synonym: "sulfuric acid, monododecyl ester" RELATED [ChemIDplus] xref: Beilstein:1710530 {source="ChemIDplus"} xref: CAS:151-41-7 {source="ChemIDplus"} xref: Gmelin:220505 {source="Gmelin"} xref: PDBeChem:SDS is_a: CHEBI:29281 ! alkyl sulfate relationship: is_conjugate_acid_of CHEBI:23872 ! dodecyl sulfate property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H26O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H26O4S/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15/h2-12H2,1H3,(H,13,14,15)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MOTZDAYCYVMXPC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "266.39844" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "266.15518" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCOS(O)(=O)=O" xsd:string [Term] id: CHEBI:45615 name: salicylhydroxamic acid namespace: chebi_ontology alt_id: CHEBI:9007 def: "A hydroxamic acid that is N-hydroxybenzamide carrying a phenolic hydroxy group at position 2." [] subset: 3_STAR synonym: "2-Hydroxybenzhydroxamic acid" RELATED [ChemIDplus] synonym: "2-Hydroxybenzohydroxamic acid" RELATED [ChemIDplus] synonym: "N,2-dihydroxybenzamide" EXACT IUPAC_NAME [IUPAC] synonym: "o-Hydroxybenzohydroxamic acid" RELATED [ChemIDplus] synonym: "Salicylohydroximic acid" RELATED [ChemIDplus] synonym: "SHAM" RELATED [ChEBI] xref: CAS:89-73-6 {source="ChemIDplus"} xref: CAS:89-73-6 {source="KEGG COMPOUND"} xref: DrugBank:DB03819 xref: KEGG:C11343 xref: MetaCyc:CPD-6543 xref: Patent:CN101519365 xref: PDBeChem:SHA xref: PMID:16667326 {source="Europe PMC"} xref: PMID:1847381 {source="Europe PMC"} xref: PMID:22554042 {source="Europe PMC"} xref: PMID:23416493 {source="Europe PMC"} xref: PMID:24603484 {source="Europe PMC"} xref: PMID:24888389 {source="Europe PMC"} xref: PMID:2543361 {source="Europe PMC"} xref: Reaxys:1210520 {source="Reaxys"} xref: Wikipedia:Salicylhydroxamic_acid is_a: CHEBI:24650 ! hydroxamic acid is_a: CHEBI:33853 ! phenols relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug relationship: RO:0000087 CHEBI:50635 ! has role EC 3.5.1.5 (urease) inhibitor relationship: RO:0000087 CHEBI:79093 ! has role EC 1.11.2.2 (myeloperoxidase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H7NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HBROZNQEVUILML-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "153.13540" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "153.04259" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "ONC(=O)c1ccccc1O" xsd:string [Term] id: CHEBI:45696 name: hydrogensulfate namespace: chebi_ontology alt_id: CHEBI:29199 alt_id: CHEBI:45693 subset: 3_STAR synonym: "[SO3(OH)](-)" RELATED [IUPAC] synonym: "HSO4(-)" RELATED [IUPAC] synonym: "HYDROGEN SULFATE" RELATED [PDBeChem] synonym: "hydrogen(tetraoxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogensulfate" EXACT [IUPAC] synonym: "hydrogensulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentetraoxosulfate(1-)" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogentetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC] synonym: "hydroxidotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC] xref: Gmelin:2121 {source="Gmelin"} is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HO4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "97.07154" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.96010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OS([O-])(=O)=O" xsd:string [Term] id: CHEBI:45924 name: trimethoprim namespace: chebi_ontology alt_id: CHEBI:45921 alt_id: CHEBI:9731 def: "An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge." [] subset: 3_STAR synonym: "2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine" RELATED [NIST_Chemistry_WebBook] synonym: "5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine" EXACT IUPAC_NAME [IUPAC] synonym: "5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine" RELATED [NIST_Chemistry_WebBook] synonym: "Proloprim" RELATED [ChemIDplus] synonym: "TRIMETHOPRIM" EXACT [PDBeChem] synonym: "Trimethoprim" EXACT [KEGG_COMPOUND] synonym: "Trimpex" RELATED [ChemIDplus] xref: Beilstein:625127 {source="Beilstein"} xref: CAS:738-70-5 {source="ChemIDplus"} xref: CAS:738-70-5 {source="NIST Chemistry WebBook"} xref: CAS:738-70-5 {source="KEGG COMPOUND"} xref: Drug_Central:2755 {source="DrugCentral"} xref: DrugBank:DB00440 xref: Gmelin:808843 {source="Gmelin"} xref: HMDB:HMDB0014583 xref: KEGG:C01965 xref: KEGG:D00145 xref: LINCS:LSM-5246 xref: PDBeChem:TOP xref: PMID:10423629 {source="Europe PMC"} xref: PMID:10969053 {source="Europe PMC"} xref: PMID:11051625 {source="Europe PMC"} xref: PMID:14629008 {source="Europe PMC"} xref: PMID:15203044 {source="Europe PMC"} xref: PMID:16311012 {source="Europe PMC"} xref: PMID:18816075 {source="Europe PMC"} xref: PMID:25111783 {source="Europe PMC"} xref: PMID:25361939 {source="Europe PMC"} xref: PMID:26546758 {source="Europe PMC"} xref: PMID:26566149 {source="Europe PMC"} xref: PMID:26942256 {source="Europe PMC"} xref: PMID:26987772 {source="Europe PMC"} xref: PMID:28166217 {source="Europe PMC"} xref: PMID:7602118 {source="Europe PMC"} xref: PMID:8911701 {source="Europe PMC"} xref: Reaxys:625127 {source="Reaxys"} xref: VSDB:1745 xref: Wikipedia:Trimethoprim is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:51683 ! methoxybenzenes relationship: RO:0000087 CHEBI:35498 ! has role diuretic relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50683 ! has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H18N4O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IEDVJHCEMCRBQM-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "290.318" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "290.13789" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1(CC=2C(=NC(N)=NC2)N)C=C(C(OC)=C(C1)OC)OC" xsd:string [Term] id: CHEBI:45979 name: thiabendazole namespace: chebi_ontology alt_id: CHEBI:45977 alt_id: CHEBI:9526 def: "A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium." [] subset: 3_STAR synonym: "2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE" RELATED [PDBeChem] synonym: "2-(1,3-thiazol-4-yl)-1H-benzimidazole" EXACT IUPAC_NAME [IUPAC] synonym: "2-(1,3-thiazol-4-yl)benzimidazole" RELATED [Alan_Wood's_Pesticides] synonym: "2-(4-thiazolyl)-1H-benzimidazole" RELATED [Alan_Wood's_Pesticides] synonym: "2-(thiazol-4-yl)benzimidazole" RELATED [Alan_Wood's_Pesticides] synonym: "4-(2-benzimidazolyl)thiazole" RELATED [ChemIDplus] synonym: "Equizole" RELATED BRAND_NAME [ChemIDplus] synonym: "Mintezol" RELATED BRAND_NAME [KEGG_DRUG] synonym: "MK 360" RELATED [ChemIDplus] synonym: "TBZ" RELATED [ChemIDplus] synonym: "Thiabendazole" EXACT [KEGG_COMPOUND] synonym: "Thibenzole" RELATED BRAND_NAME [ChemIDplus] synonym: "Tiabendazole" RELATED [KEGG_COMPOUND] xref: Beilstein:611403 {source="Beilstein"} xref: CAS:148-79-8 {source="ChemIDplus"} xref: CAS:148-79-8 {source="NIST Chemistry WebBook"} xref: Drug_Central:2621 {source="DrugCentral"} xref: DrugBank:DB00730 xref: HMDB:HMDB0014868 xref: KEGG:D00372 xref: LINCS:LSM-3741 xref: MetaCyc:THIABENDAZOLE xref: Patent:US3017415 xref: PDBeChem:TMG xref: Pesticides:thiabendazole {source="Alan Wood's Pesticides"} xref: PMID:11226373 {source="Europe PMC"} xref: PMID:13900465 {source="Europe PMC"} xref: PMID:23790859 {source="Europe PMC"} xref: PMID:9009055 {source="Europe PMC"} xref: PPDB:629 xref: Reaxys:611403 {source="Reaxys"} xref: VSDB:629 xref: Wikipedia:Thiabendazole is_a: CHEBI:38418 ! 1,3-thiazoles is_a: CHEBI:87036 ! benzimidazole fungicide relationship: has_parent_hydride CHEBI:41275 ! 1H-benzimidazole relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H7N3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WJCNZQLZVWNLKY-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "201.24800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "201.03607" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1nc(cs1)-c1nc2ccccc2[nH]1" xsd:string [Term] id: CHEBI:46024 name: trichostatin A namespace: chebi_ontology alt_id: CHEBI:39145 alt_id: CHEBI:46022 subset: 3_STAR synonym: "(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide" RELATED [ChemIDplus] synonym: "(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide" EXACT IUPAC_NAME [IUPAC] synonym: "TRICHOSTATIN A" EXACT [PDBeChem] synonym: "TSA" RELATED [ChemIDplus] xref: Beilstein:5291761 {source="Beilstein"} xref: CAS:58880-19-6 {source="ChemIDplus"} xref: DrugBank:DB04297 xref: HMDB:HMDB0259177 xref: KNApSAcK:C00016002 xref: PDBeChem:TSN xref: PMID:10490031 {source="Europe PMC"} xref: PMID:15346199 {source="Europe PMC"} xref: PMID:16010430 {source="Europe PMC"} xref: PMID:18285338 {source="Europe PMC"} xref: PMID:19038231 {source="Europe PMC"} xref: PMID:21504214 {source="Europe PMC"} xref: PMID:25075551 {source="Europe PMC"} xref: PMID:27454931 {source="Europe PMC"} xref: PMID:30395713 {source="Europe PMC"} xref: PMID:31755702 {source="Europe PMC"} xref: PMID:32880591 {source="Europe PMC"} xref: PMID:33983895 {source="Europe PMC"} xref: PMID:34086940 {source="Europe PMC"} xref: Wikipedia:Trichostatin_A is_a: CHEBI:24650 ! hydroxamic acid is_a: CHEBI:39146 ! trichostatin is_a: CHEBI:86478 ! antibiotic antifungal agent relationship: has_functional_parent CHEBI:39158 ! (R)-trichostatic acid relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:61115 ! has role EC 3.5.1.98 (histone deacetylase) inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H22N2O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RTKIYFITIVXBLE-QEQCGCAPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "302.36826" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "302.16304" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](C(=O)c1ccc(cc1)N(C)C)\\C=C(C)\\C=C\\C(=O)NO" xsd:string [Term] id: CHEBI:46077 name: 4H-1,2,4-triazole namespace: chebi_ontology alt_id: CHEBI:35548 alt_id: CHEBI:46076 subset: 3_STAR synonym: "1,2,4-TRIAZOLE" RELATED [PDBeChem] synonym: "4H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:605619 {source="Beilstein"} xref: CAS:63598-71-0 {source="NIST Chemistry WebBook"} xref: CAS:63598-71-0 {source="ChemIDplus"} xref: Gmelin:323206 {source="Gmelin"} xref: PDBeChem:TRI is_a: CHEBI:35560 ! 1,2,4-triazole relationship: is_tautomer_of CHEBI:35550 ! 1H-1,2,4-triazole relationship: is_tautomer_of CHEBI:35561 ! 3H-1,2,4-triazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3N3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H3N3/c1-3-2-5-4-1/h1-2H,(H,3,4,5)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NSPMIYGKQJPBQR-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "69.06544" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "69.03270" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1nnc[nH]1" xsd:string [Term] id: CHEBI:46081 name: fluconazole namespace: chebi_ontology alt_id: CHEBI:46079 alt_id: CHEBI:5099 def: "A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis." [] subset: 3_STAR synonym: "2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol" RELATED [ChemIDplus] synonym: "2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol" EXACT IUPAC_NAME [IUPAC] synonym: "2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL" RELATED [PDBeChem] synonym: "Biozole" RELATED BRAND_NAME [ChEBI] synonym: "Diflucan" RELATED BRAND_NAME [ChEBI] synonym: "Elazor" RELATED [ChemIDplus] synonym: "fluconazol" RELATED INN [ChemIDplus] synonym: "fluconazole" EXACT [UniProt] synonym: "fluconazole" RELATED INN [ChemIDplus] synonym: "fluconazole" RELATED INN [WHO_MedNet] synonym: "fluconazolum" RELATED INN [ChemIDplus] synonym: "Triflucan" RELATED BRAND_NAME [ChEBI] xref: Beilstein:4269710 {source="Beilstein"} xref: CAS:86386-73-4 {source="ChemIDplus"} xref: Drug_Central:1187 {source="DrugCentral"} xref: DrugBank:DB00196 xref: HMDB:HMDB0014342 xref: KEGG:D00322 xref: LINCS:LSM-2106 xref: Patent:GB2099818 xref: Patent:US4404216 xref: PDBeChem:TPF xref: PMID:11366931 {source="Europe PMC"} xref: PMID:16822276 {source="Europe PMC"} xref: PMID:23171950 {source="Europe PMC"} xref: PMID:23793863 {source="Europe PMC"} xref: Reaxys:7311650 {source="Reaxys"} xref: Wikipedia:Fluconazole is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:38582 ! difluorobenzene is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: has_functional_parent CHEBI:38584 ! 1,3-difluorobenzene relationship: has_parent_hydride CHEBI:35550 ! 1H-1,2,4-triazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H12F2N6O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RFHAOTPXVQNOHP-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "306.27080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "306.10407" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F" xsd:string [Term] id: CHEBI:46416 name: virginiamycin S1 namespace: chebi_ontology alt_id: CHEBI:9998 def: "A cyclodepsipeptide that is N-(3-hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine in which the carboxy group of the 2-phenylglycine moiety has undergone formal intramolecular condensation with the hydroxy group of the N-(3-hydroxypicolinoyl)-L-threonyl to give the corresponding 19-membered ring lactone. It is one of the two major components of the antibacterial drug virginiamycin, produced by Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others." [] subset: 3_STAR synonym: "N-((3-hydroxy-2-pyridinyl)carbonyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine rho-lactone" RELATED [ChemIDplus] synonym: "N-(3-hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine rho-lactone" RELATED [ChemIDplus] synonym: "N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-benzyl-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxypyridine-2-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "virginiamycin factor S" RELATED [ChemIDplus] synonym: "Virginiamycin S1" EXACT [KEGG_COMPOUND] synonym: "virginiamycin S1" EXACT [ChemIDplus] xref: CAS:23152-29-6 {source="KEGG COMPOUND"} xref: CAS:23152-29-6 {source="ChemIDplus"} xref: DrugBank:DB04805 xref: KEGG:C11269 xref: PDBeChem:VRS xref: PMID:1493906 {source="Europe PMC"} xref: PMID:22934408 {source="Europe PMC"} xref: PMID:3097264 {source="Europe PMC"} xref: PMID:4142724 {source="Europe PMC"} xref: Reaxys:3647647 {source="Reaxys"} xref: Wikipedia:Virginiamycin_S1 is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:35213 ! cyclodepsipeptide relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C43H49N7O10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C43H49N7O10/c1-4-29-40(56)49-21-12-17-30(49)41(57)48(3)32(23-26-13-7-5-8-14-26)42(58)50-22-19-28(51)24-31(50)37(53)47-35(27-15-9-6-10-16-27)43(59)60-25(2)34(38(54)45-29)46-39(55)36-33(52)18-11-20-44-36/h5-11,13-16,18,20,25,29-32,34-35,52H,4,12,17,19,21-24H2,1-3H3,(H,45,54)(H,46,55)(H,47,53)/t25-,29-,30+,31+,32+,34+,35+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FEPMHVLSLDOMQC-IYPFLVAKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "823.89010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "823.35409" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O)c1ccccc1" xsd:string [Term] id: CHEBI:46577 name: dextrofloxacin namespace: chebi_ontology def: "The (R)-enantiomer of ofloxacin." [] subset: 3_STAR synonym: "(+)-ofloxacin" RELATED [ChEBI] synonym: "(3R)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "(R)-(+)-ofloxacin" RELATED [ChEBI] synonym: "(R)-ofloxacin" RELATED [ChEBI] synonym: "D-levofloxacin" RELATED [DrugBank] synonym: "D-ofloxacin" RELATED [ChemIDplus] synonym: "dextrofloxacine" RELATED [PDBeChem] synonym: "DR 3354" RELATED [ChEBI] synonym: "DR-3354" RELATED [ChEBI] synonym: "DR3354" RELATED [ChEBI] synonym: "R-(+)-ofloxacin" RELATED [ChEBI] synonym: "R-ofloxacin" RELATED [ChemIDplus] xref: CAS:100986-86-5 {source="ChemIDplus"} xref: DrugBank:DB03034 xref: PDBeChem:XED xref: PMID:15769740 {source="Europe PMC"} xref: PMID:17870541 {source="Europe PMC"} xref: PMID:17937485 {source="Europe PMC"} xref: PMID:1992111 {source="Europe PMC"} xref: PMID:2079448 {source="Europe PMC"} xref: PMID:25069865 {source="Europe PMC"} xref: PMID:26179954 {source="Europe PMC"} xref: PMID:2824776 {source="Europe PMC"} xref: PMID:29513966 {source="Europe PMC"} xref: PMID:32208173 {source="Europe PMC"} xref: PMID:7478164 {source="Europe PMC"} is_a: CHEBI:194135 ! 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_enantiomer_of CHEBI:63598 ! levofloxacin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H20FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GSDSWSVVBLHKDQ-SNVBAGLBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "361.373" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "361.14378" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H]1COC2=C(N3CCN(C)CC3)C(F)=CC3=C2N1C=C(C(O)=O)C3=O" xsd:string [Term] id: CHEBI:46629 name: oxo group namespace: chebi_ontology alt_id: CHEBI:29353 alt_id: CHEBI:44607 subset: 3_STAR synonym: "=O" RELATED [IUPAC] synonym: "oxo" EXACT IUPAC_NAME [IUPAC] synonym: "OXO GROUP" EXACT [PDBeChem] xref: PDBeChem:O is_a: CHEBI:33246 ! inorganic group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=*" xsd:string [Term] id: CHEBI:46633 name: carbapenems namespace: chebi_ontology def: "The class of beta-lactam antibiotics that whose members have a carbapenem skeleton which is variously substituted at positions 3, 4, and 6." [] subset: 3_STAR xref: PMID:18076336 {source="Europe PMC"} xref: PMID:19199922 {source="Europe PMC"} xref: PMID:19610642 {source="Europe PMC"} xref: PMID:19617229 {source="Europe PMC"} xref: PMID:19929840 {source="Europe PMC"} xref: PMID:21859938 {source="Europe PMC"} xref: Wikipedia:Carbapenem is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:27933 ! beta-lactam antibiotic relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H4NO3R3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "150.112" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "150.01912" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C([*])C(=O)N1C(C(O)=O)=C([*])C2[*]" xsd:string [Term] id: CHEBI:46634 name: carbapenemcarboxylic acid namespace: chebi_ontology subset: 3_STAR synonym: "carbapenemcarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:46633 ! carbapenems [Term] id: CHEBI:46662 name: mineral namespace: chebi_ontology def: "In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals')." [] subset: 3_STAR synonym: "mineral" EXACT [ChEBI] synonym: "Minerale" RELATED [ChEBI] synonym: "minerales" RELATED [ChEBI] synonym: "minerals" RELATED [ChEBI] synonym: "mineraux" RELATED [ChEBI] xref: Wikipedia:Mineral is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:46686 name: azaalkane namespace: chebi_ontology subset: 3_STAR synonym: "azaalkanes" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:46687 name: diazaalkane namespace: chebi_ontology subset: 3_STAR synonym: "diazaalkanes" RELATED [ChEBI] is_a: CHEBI:39474 ! polyazaalkane [Term] id: CHEBI:46733 name: oxabicycloalkane namespace: chebi_ontology subset: 3_STAR synonym: "oxabicycloalkanes" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:46761 name: dipeptide namespace: chebi_ontology alt_id: CHEBI:23835 alt_id: CHEBI:4634 def: "Any molecule that contains two amino-acid residues connected by peptide linkages." [] subset: 3_STAR synonym: "Dipeptid" RELATED [ChEBI] synonym: "Dipeptide" EXACT [KEGG_COMPOUND] synonym: "dipeptides" RELATED [ChEBI] xref: KEGG:C00107 is_a: CHEBI:25676 ! oligopeptide relationship: is_tautomer_of CHEBI:90799 ! dipeptide zwitterion [Term] id: CHEBI:46770 name: pyrrolidinecarboxamide namespace: chebi_ontology subset: 3_STAR synonym: "pyrrolidinecarboxamides" RELATED [ChEBI] is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:38260 ! pyrrolidines [Term] id: CHEBI:46774 name: polyether namespace: chebi_ontology def: "Any ether that contains more than one ether linkage." [] subset: 3_STAR synonym: "polyether" EXACT [ChEBI] synonym: "polyethers" RELATED [ChEBI] is_a: CHEBI:25698 ! ether [Term] id: CHEBI:46786 name: diether namespace: chebi_ontology def: "A polyether in which the number of ether linkages is 2." [] subset: 3_STAR synonym: "diether" EXACT [ChEBI] synonym: "diethers" RELATED [ChEBI] is_a: CHEBI:46774 ! polyether [Term] id: CHEBI:46787 name: solvent namespace: chebi_ontology def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." [] subset: 3_STAR synonym: "Loesungsmittel" RELATED [ChEBI] synonym: "solvant" RELATED [ChEBI] synonym: "solvents" RELATED [ChEBI] xref: Wikipedia:Solvent is_a: CHEBI:33232 ! application is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:46812 name: 1,3-oxazoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:35790 ! oxazole [Term] id: CHEBI:46844 name: N-acylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-acylpiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:32988 ! amide [Term] id: CHEBI:46845 name: N-alkylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-alkylpiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:50996 ! tertiary amino compound [Term] id: CHEBI:46847 name: N-iminopiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-iminopiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines [Term] id: CHEBI:46848 name: N-arylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-arylpiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:50996 ! tertiary amino compound [Term] id: CHEBI:46850 name: organoammonium salt namespace: chebi_ontology subset: 3_STAR synonym: "organoammonium salts" RELATED [ChEBI] is_a: CHEBI:35276 ! ammonium compound [Term] id: CHEBI:46883 name: carboxy group namespace: chebi_ontology alt_id: CHEBI:23025 alt_id: CHEBI:41420 subset: 3_STAR synonym: "-C(O)OH" RELATED [IUPAC] synonym: "-CO2H" RELATED [ChEBI] synonym: "-COOH" RELATED [IUPAC] synonym: "carboxy" EXACT IUPAC_NAME [IUPAC] synonym: "CARBOXY GROUP" EXACT [PDBeChem] synonym: "carboxyl group" RELATED [ChEBI] xref: PDBeChem:FMT is_a: CHEBI:33249 ! organyl group property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01744" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(=O)O" xsd:string [Term] id: CHEBI:46895 name: lipopeptide namespace: chebi_ontology def: "A compound consisting of a peptide with attached lipid." [] subset: 3_STAR synonym: "lipopeptides" RELATED [ChEBI] synonym: "LP" RELATED [ChEBI] xref: PMID:19889045 {source="Europe PMC"} xref: PMID:20545290 {source="Europe PMC"} xref: PMID:23131643 {source="Europe PMC"} xref: PMID:23318669 {source="Europe PMC"} xref: Wikipedia:Lipopeptide is_a: CHEBI:16670 ! peptide is_a: CHEBI:18059 ! lipid [Term] id: CHEBI:46912 name: ornithinium(1+) namespace: chebi_ontology subset: 3_STAR synonym: "2,5-diammoniopentanoate" EXACT IUPAC_NAME [IUPAC] synonym: "ornithine monocation" RELATED [JCBN] synonym: "ornithinium" EXACT IUPAC_NAME [IUPAC] synonym: "ornithinium(1+)" EXACT [JCBN] is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:18257 ! ornithine relationship: is_conjugate_base_of CHEBI:46913 ! ornithinium(2+) relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H13N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "133.16900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "133.09715" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]CCCC([NH3+])C([O-])=O" xsd:string [Term] id: CHEBI:46913 name: ornithinium(2+) namespace: chebi_ontology subset: 3_STAR synonym: "1-carboxybutane-1,4-diaminium" EXACT IUPAC_NAME [IUPAC] synonym: "ornithine dication" RELATED [JCBN] synonym: "ornithinediium" EXACT IUPAC_NAME [IUPAC] synonym: "ornithinium(2+)" EXACT [JCBN] is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:46912 ! ornithinium(1+) property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H14N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AHLPHDHHMVZTML-UHFFFAOYSA-P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "134.17694" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "134.10443" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]CCCC([NH3+])C(O)=O" xsd:string [Term] id: CHEBI:46920 name: N-methylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-methylpiperazines" RELATED [ChEBI] is_a: CHEBI:46845 ! N-alkylpiperazine [Term] id: CHEBI:46942 name: oxanes namespace: chebi_ontology def: "Any organic heteromonocyclic compoundthat is oxane or its substituted derivatives." [] subset: 3_STAR synonym: "tetrahydropyrans" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:46952 name: oxazinane namespace: chebi_ontology subset: 3_STAR synonym: "oxazinanes" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:47017 name: tetrahydrofuranol namespace: chebi_ontology subset: 3_STAR synonym: "tetrahydrofuranols" RELATED [ChEBI] is_a: CHEBI:26912 ! oxolanes [Term] id: CHEBI:47019 name: dihydroxytetrahydrofuran namespace: chebi_ontology subset: 3_STAR synonym: "dihydroxytetrahydrofurans" RELATED [ChEBI] is_a: CHEBI:47017 ! tetrahydrofuranol [Term] id: CHEBI:471744 name: imipenem namespace: chebi_ontology alt_id: CHEBI:5879 def: "A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup." [] subset: 3_STAR synonym: "(5R,6S)-3-((2-(Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid" RELATED [ChemIDplus] synonym: "(5R,6S)-3-(2-Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "(5R,6S)-6-((R)-1-Hydroxyethyl)-3-(2-(iminomethylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure" RELATED [ChemIDplus] synonym: "(5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Imipenem" EXACT [KEGG_COMPOUND] synonym: "Imipenem anhydrous" RELATED [KEGG_COMPOUND] synonym: "imipenemum" RELATED [ChemIDplus] synonym: "N-formimidoyl thienamycin" RELATED [Patent] synonym: "N-formimidoylthienamycin" RELATED [ChemIDplus] xref: Beilstein:434624 {source="Beilstein"} xref: CAS:64221-86-9 {source="ChemIDplus"} xref: CAS:64221-86-9 {source="KEGG COMPOUND"} xref: Drug_Central:1426 {source="DrugCentral"} xref: DrugBank:DB01598 xref: KEGG:C06665 xref: KEGG:D04515 xref: LINCS:LSM-6568 xref: Patent:BE848545 xref: Patent:US4194047 xref: PMID:1384868 {source="Europe PMC"} xref: PMID:17361077 {source="Europe PMC"} xref: PMID:24112243 {source="Europe PMC"} xref: PMID:24247132 {source="Europe PMC"} xref: PMID:2457043 {source="Europe PMC"} xref: PMID:24903189 {source="Europe PMC"} xref: PMID:25216543 {source="Europe PMC"} xref: PMID:25351714 {source="Europe PMC"} xref: PMID:9131470 {source="Europe PMC"} xref: Reaxys:434624 {source="Reaxys"} xref: Wikipedia:Imipenem is_a: CHEBI:46633 ! carbapenems is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_tautomer_of CHEBI:190509 ! imipenem zwitterion relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H17N3O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H17N3O4S/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/t6-,7-,9-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZSKVGTPCRGIANV-ZXFLCMHBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "299.34720" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "299.09398" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=N)NCCSC1=C(N2C(=O)[C@]([H])([C@@H](C)O)[C@@]2([H])C1)C(O)=O" xsd:string [Term] id: CHEBI:472657 name: cefixime namespace: chebi_ontology alt_id: CHEBI:3487 def: "A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections." [] subset: 3_STAR synonym: "(-)-cefixim" RELATED [ChemIDplus] synonym: "(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "7beta-{(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido}-3-ethenyl-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "cefixima" RELATED INN [ChemIDplus] synonym: "cefixime" RELATED INN [ChemIDplus] synonym: "cefiximum" RELATED INN [ChemIDplus] xref: Beilstein:6025058 {source="Beilstein"} xref: CAS:79350-37-1 {source="KEGG COMPOUND"} xref: CAS:79350-37-1 {source="ChemIDplus"} xref: Drug_Central:537 {source="DrugCentral"} xref: DrugBank:DB00671 xref: KEGG:C06881 xref: KEGG:D00258 xref: Patent:EP30630 xref: Patent:US4409214 xref: PMID:17116681 {source="ChEMBL"} xref: PMID:29017833 {source="Europe PMC"} is_a: CHEBI:23066 ! cephalosporin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H15N5O7S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OKBVVJOGVLARMR-QSWIMTSFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "453.45000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "453.04129" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC(O)=O)\\c1csc(N)n1)C(O)=O" xsd:string [Term] id: CHEBI:473992 name: nystatin A1 namespace: chebi_ontology alt_id: CHEBI:31926 def: "A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species." [] subset: 3_STAR synonym: "(1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "nystatin A1" EXACT [LIPID_MAPS] xref: Beilstein:12153125 {source="Beilstein"} xref: CAS:34786-70-4 {source="ChemIDplus"} xref: HMDB:HMDB0242564 xref: KEGG:C12155 xref: LIPID_MAPS_instance:LMPK06000004 {source="LIPID MAPS"} xref: PMID:1086913 {source="Europe PMC"} xref: PMID:12230565 {source="Europe PMC"} xref: PMID:15034898 {source="Europe PMC"} xref: PMID:19362643 {source="Europe PMC"} xref: PMID:2010357 {source="Europe PMC"} xref: PMID:24231162 {source="Europe PMC"} xref: PMID:24924305 {source="Europe PMC"} xref: PMID:25082221 {source="Europe PMC"} xref: PMID:26233316 {source="Europe PMC"} xref: PMID:27379602 {source="Europe PMC"} xref: PMID:28488115 {source="Europe PMC"} xref: PMID:28555391 {source="Europe PMC"} xref: PMID:30206268 {source="Europe PMC"} xref: PMID:31924510 {source="Europe PMC"} xref: PMID:32038598 {source="Europe PMC"} xref: PMID:33932153 {source="Europe PMC"} xref: PMID:34275291 {source="Europe PMC"} xref: PMID:34938275 {source="Europe PMC"} xref: PMID:6331301 {source="Europe PMC"} xref: PMID:9188800 {source="Europe PMC"} xref: VSDB:2985 is_a: CHEBI:59676 ! nystatins property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C47H75NO17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VQOXZBDYSJBXMA-NQTDYLQESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "926.107" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "925.50350" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\CC\\C=C\\C=C\\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2" xsd:string [Term] id: CHEBI:474053 name: cefazolin namespace: chebi_ontology alt_id: CHEBI:3482 def: "A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively." [] subset: 3_STAR synonym: "(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Cefamezin" RELATED [ChemIDplus] synonym: "cefazolin" RELATED INN [ChemIDplus] synonym: "cefazolina" RELATED INN [ChemIDplus] synonym: "cefazoline" RELATED INN [ChemIDplus] synonym: "cefazolinum" RELATED INN [ChemIDplus] synonym: "Cephamezine" RELATED [ChemIDplus] synonym: "Cephazolidin" RELATED [ChemIDplus] synonym: "Cephazolin" RELATED [ChemIDplus] synonym: "Cephazoline" RELATED [ChemIDplus] synonym: "CEZ" RELATED [ChEBI] xref: Beilstein:4169371 {source="Beilstein"} xref: CAS:25953-19-9 {source="KEGG DRUG"} xref: CAS:25953-19-9 {source="ChemIDplus"} xref: CAS:25953-19-9 {source="DrugBank"} xref: CAS:25953-19-9 {source="KEGG COMPOUND"} xref: Drug_Central:530 {source="DrugCentral"} xref: DrugBank:DB01327 xref: HMDB:HMDB0015422 xref: KEGG:C06880 xref: KEGG:D02299 xref: LINCS:LSM-34744 xref: Patent:US3516997 xref: PMID:12569987 {source="Europe PMC"} xref: PMID:2083978 {source="Europe PMC"} xref: PMID:22011388 {source="Europe PMC"} xref: PMID:23702270 {source="Europe PMC"} xref: PMID:24462449 {source="Europe PMC"} xref: PMID:28543395 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:6176550 {source="Europe PMC"} xref: Reaxys:4169371 {source="Reaxys"} xref: VSDB:1910 xref: Wikipedia:Cefazolin is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:35689 ! tetrazoles is_a: CHEBI:38099 ! thiadiazoles is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_conjugate_acid_of CHEBI:53657 ! cefazolin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H14N8O4S3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MLYYVTUWGNIJIB-BXKDBHETSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "454.511" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "454.03001" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@]12(N(C(=C(CS1)CSC3=NN=C(S3)C)C(=O)O)C([C@H]2NC(=O)CN4C=NN=N4)=O)[H]" xsd:string [Term] id: CHEBI:474180 name: caspofungin namespace: chebi_ontology alt_id: CHEBI:599509 def: "A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall." [] subset: 3_STAR synonym: "(10R,12S)-N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide" EXACT IUPAC_NAME [IUPAC] synonym: "(4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide" RELATED [ChemIDplus] synonym: "1-[(4R,5S)-5-[(2-aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0" RELATED [ChEBI] synonym: "Caspofungin" EXACT [ChEMBL] synonym: "caspofungin" RELATED INN [ChemIDplus] xref: Beilstein:8471798 {source="Beilstein"} xref: CAS:162808-62-0 {source="KEGG DRUG"} xref: CAS:162808-62-0 {source="ChemIDplus"} xref: Drug_Central:2977 {source="DrugCentral"} xref: DrugBank:DB00520 xref: KEGG:D07626 xref: Patent:US5378804 xref: Patent:WO9421677 xref: PMID:24270605 {source="Europe PMC"} is_a: CHEBI:24613 ! homodetic cyclic peptide is_a: CHEBI:57248 ! echinocandin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: has_functional_parent CHEBI:131609 ! pneumocandin B0 property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C52H88N10O15" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C52H88N10O15/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JYIKNQVWKBUSNH-WVDDFWQHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1093.315" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1092.64306" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@]12(N(C[C@@H](C1)O)C([C@H]([C@@H](C)O)NC(=O)[C@](C[C@H]([C@@H](NCCN)NC([C@@H]3[C@H](CCN3C([C@H]([C@@H](CCN)O)NC(=O)[C@H]([C@@H]([C@H](C4=CC=C(C=C4)O)O)O)NC2=O)=O)O)=O)O)(NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)[H])=O)[H]" xsd:string [Term] id: CHEBI:47518 name: (2S,4R)-ketoconazole namespace: chebi_ontology def: "A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration." [] subset: 3_STAR synonym: "(2S,4R)-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" RELATED [ChEBI] synonym: "(2S,4R)-ketoconazole" EXACT [UniProt] synonym: "1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE" RELATED [PDBeChem] synonym: "1-acetyl-4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:5488107 {source="Beilstein"} xref: PDBeChem:KLN is_a: CHEBI:86411 ! cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine relationship: is_enantiomer_of CHEBI:48336 ! (2R,4S)-ketoconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H28Cl2N4O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XMAYWYJOQHXEEK-ZEQKJWHPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "531.43048" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "530.14876" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1" xsd:string [Term] id: CHEBI:47519 name: ketoconazole namespace: chebi_ontology alt_id: CHEBI:6126 def: "A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole." [] subset: 3_STAR synonym: "(+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine" RELATED [ChemIDplus] synonym: "cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine" RELATED [ChemIDplus] synonym: "Fungarest" RELATED BRAND_NAME [DrugBank] synonym: "Fungoral" RELATED BRAND_NAME [DrugBank] synonym: "ketoconazol" RELATED INN [WHO_MedNet] synonym: "ketoconazole" RELATED INN [ChemIDplus] synonym: "ketoconazole" RELATED INN [WHO_MedNet] synonym: "ketoconazolum" RELATED INN [ChemIDplus] synonym: "Ketoderm" RELATED BRAND_NAME [DrugBank] synonym: "Ketoisdin" RELATED BRAND_NAME [DrugBank] synonym: "Nizoral" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Panfungol" RELATED BRAND_NAME [DrugBank] synonym: "rac-1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" EXACT IUPAC_NAME [IUPAC] synonym: "Xolegel" RELATED BRAND_NAME [KEGG_DRUG] xref: Beilstein:4303081 {source="ChemIDplus"} xref: CAS:65277-42-1 {source="ChemIDplus"} xref: CAS:65277-42-1 {source="KEGG DRUG"} xref: DrugBank:DB01026 xref: Gmelin:1713206 {source="Gmelin"} xref: HMDB:HMDB0012242 xref: KEGG:D00351 xref: Patent:DE2804096 xref: Patent:US4144346 is_a: CHEBI:60911 ! racemate is_a: CHEBI:87069 ! imidazole antifungal drug is_a: CHEBI:87071 ! conazole antifungal drug relationship: has_part CHEBI:47518 ! (2S,4R)-ketoconazole relationship: has_part CHEBI:48336 ! (2R,4S)-ketoconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H28Cl2N4O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "531.43048" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "530.14876" xsd:string [Term] id: CHEBI:47724 name: vancomycin aglycone namespace: chebi_ontology def: "A peptide antibiotic that is vancomycin lacking the disaccharide moiety." [] subset: 3_STAR synonym: "(1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37,48-hexahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Aglucovancomycin B" RELATED [ChemIDplus] synonym: "Balhimycin aglycon" RELATED [ChemIDplus] xref: CAS:82198-76-3 {source="ChemIDplus"} xref: MetaCyc:CPD-15745 xref: PMID:11470430 {source="Europe PMC"} xref: PMID:14649827 {source="Europe PMC"} xref: PMID:15785812 {source="Europe PMC"} xref: PMID:22177724 {source="Europe PMC"} xref: Reaxys:6049255 {source="Reaxys"} is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:37407 ! cyclic ether relationship: is_conjugate_acid_of CHEBI:77981 ! vancomycin aglycone(1-) relationship: is_tautomer_of CHEBI:75954 ! vancomycin aglycone zwitterion relationship: RO:0000087 CHEBI:25212 ! has role metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H52Cl2N8O17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H52Cl2N8O17/c1-19(2)10-29(57-3)47(71)62-42-44(68)21-5-8-33(27(54)12-21)79-35-14-23-15-36(46(35)70)80-34-9-6-22(13-28(34)55)45(69)43-52(76)61-41(53(77)78)26-16-24(64)17-32(66)38(26)25-11-20(4-7-31(25)65)39(49(73)63-43)60-50(74)40(23)59-48(72)30(18-37(56)67)58-51(42)75/h4-9,11-17,19,29-30,39-45,57,64-66,68-70H,10,18H2,1-3H3,(H2,56,67)(H,58,75)(H,59,72)(H,60,74)(H,61,76)(H,62,71)(H,63,73)(H,77,78)/t29-,30+,39-,40-,41+,42-,43+,44-,45-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JHIKFOISFAQTJQ-YZANBJIASA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1143.92900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1142.28275" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C(O)=O)c3O)c(Cl)c2" xsd:string [Term] id: CHEBI:47779 name: aminoglycoside namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycosides" RELATED [ChEBI] is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:47811 name: penamcarboxylate namespace: chebi_ontology subset: 3_STAR synonym: "penamcarboxylates" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:35992 ! penams [Term] id: CHEBI:478164 name: cefepime namespace: chebi_ontology alt_id: CHEBI:3486 alt_id: CHEBI:473919 def: "A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidinium-1-yl)methyl]-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "cefepima" RELATED INN [ChemIDplus] synonym: "Cefepime" EXACT [KEGG_COMPOUND] synonym: "cefepime" EXACT [ChEMBL] synonym: "cefepime" RELATED INN [ChemIDplus] synonym: "cefepimum" RELATED INN [ChemIDplus] synonym: "CFPM" RELATED [ChEBI] xref: Beilstein:7453587 {source="Beilstein"} xref: CAS:88040-23-7 {source="KEGG COMPOUND"} xref: Drug_Central:535 {source="DrugCentral"} xref: DrugBank:DB01413 xref: KEGG:C08111 xref: KEGG:D02376 xref: Patent:DE3307550 xref: Patent:US4406899 xref: PMID:11084674 {source="Europe PMC"} xref: PMID:11179650 {source="Europe PMC"} xref: PMID:11191931 {source="Europe PMC"} xref: PMID:11260566 {source="Europe PMC"} xref: PMID:11280610 {source="Europe PMC"} xref: PMID:11303846 {source="Europe PMC"} xref: PMID:11306793 {source="Europe PMC"} xref: PMID:11328792 {source="Europe PMC"} xref: PMID:11431192 {source="Europe PMC"} xref: PMID:11442796 {source="Europe PMC"} xref: PMID:11864944 {source="Europe PMC"} xref: PMID:11910959 {source="Europe PMC"} xref: PMID:11964152 {source="Europe PMC"} xref: PMID:12848746 {source="Europe PMC"} xref: PMID:14628573 {source="Europe PMC"} xref: PMID:14642333 {source="Europe PMC"} xref: PMID:15303411 {source="Europe PMC"} xref: PMID:15494381 {source="Europe PMC"} xref: PMID:15830071 {source="Europe PMC"} xref: PMID:15978309 {source="Europe PMC"} xref: PMID:15980347 {source="Europe PMC"} xref: PMID:16207962 {source="Europe PMC"} xref: PMID:16650951 {source="Europe PMC"} xref: PMID:16705389 {source="Europe PMC"} xref: PMID:16930923 {source="Europe PMC"} xref: PMID:17042189 {source="Europe PMC"} xref: PMID:17214092 {source="Europe PMC"} xref: PMID:17323865 {source="Europe PMC"} xref: PMID:17448937 {source="Europe PMC"} xref: PMID:17625777 {source="Europe PMC"} xref: PMID:18025111 {source="Europe PMC"} xref: PMID:18154532 {source="Europe PMC"} xref: PMID:18651542 {source="Europe PMC"} xref: PMID:18673128 {source="Europe PMC"} xref: PMID:18717040 {source="Europe PMC"} xref: PMID:19053894 {source="Europe PMC"} xref: PMID:19304881 {source="Europe PMC"} xref: PMID:21425867 {source="Europe PMC"} xref: PMID:28543395 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:7453587 {source="Reaxys"} xref: Wikipedia:Cefepime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether relationship: is_conjugate_base_of CHEBI:59349 ! cefepime(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H24N6O5S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HVFLCNVBZFFHBT-ZKDACBOMSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "480.56100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "480.12496" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(C[N+]3(C)CCCC3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C([O-])=O" xsd:string [Term] id: CHEBI:47857 name: ureas namespace: chebi_ontology alt_id: CHEBI:27220 alt_id: CHEBI:36947 subset: 3_STAR synonym: "urea derivatives" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide relationship: has_functional_parent CHEBI:16199 ! urea [Term] id: CHEBI:47867 name: indicator namespace: chebi_ontology def: "Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc." [] subset: 3_STAR synonym: "Indikator" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:47880 name: steroid ester namespace: chebi_ontology alt_id: CHEBI:26762 subset: 3_STAR synonym: "steroid esters" RELATED [ChEBI] xref: KEGG:C15506 is_a: CHEBI:35341 ! steroid is_a: CHEBI:35701 ! ester [Term] id: CHEBI:47881 name: 3-oxo monocarboxylic acid namespace: chebi_ontology alt_id: CHEBI:13600 alt_id: CHEBI:1619 alt_id: CHEBI:35949 subset: 3_STAR synonym: "3-Keto acid" RELATED [KEGG_COMPOUND] synonym: "3-Oxo acid" RELATED [KEGG_COMPOUND] synonym: "3-oxo monocarboxylic acids" RELATED [ChEBI] synonym: "3-oxomonocarboxylic acid" RELATED [ChEBI] synonym: "3-oxomonocarboxylic acids" RELATED [ChEBI] xref: KEGG:C01656 is_a: CHEBI:35871 ! oxo monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:35973 ! 3-oxo monocarboxylic acid anion property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H2O3R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "86.046" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "86.00039" xsd:string [Term] id: CHEBI:47891 name: steroid acid namespace: chebi_ontology def: "Any steroid substituted by at least one carboxy group." [] subset: 3_STAR synonym: "steroid acids" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:64709 ! organic acid relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion [Term] id: CHEBI:47956 name: thiocarboxamide namespace: chebi_ontology def: "Any primary amide having its amide oxygen replaced by sulfur." [] subset: 3_STAR synonym: "thioamide" RELATED [ChEBI] synonym: "thiocarboxamides" RELATED [ChEBI] synonym: "thionoamide" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide [Term] id: CHEBI:47985 name: enol ether namespace: chebi_ontology def: "Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage." [] subset: 3_STAR synonym: "enol ether" EXACT [ChEBI] synonym: "enol ethers" RELATED [ChEBI] is_a: CHEBI:25698 ! ether is_a: CHEBI:78840 ! olefinic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2OR4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "40.02080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "39.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]\\C([*])=C(\\[*])O[*]" xsd:string [Term] id: CHEBI:48001 name: protein synthesis inhibitor namespace: chebi_ontology def: "A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein." [] subset: 3_STAR synonym: "protein synthesis antagonist" RELATED [ChEBI] synonym: "protein synthesis antagonists" RELATED [ChEBI] synonym: "protein synthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:48080 name: brefeldin A namespace: chebi_ontology def: "A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity." [] subset: 3_STAR synonym: "(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one" EXACT IUPAC_NAME [IUPAC] synonym: "ascotoxin" RELATED [ChemIDplus] synonym: "Brefeldin A" EXACT [ChemIDplus] synonym: "cyanein" RELATED [ChemIDplus] synonym: "decumbin" RELATED [ChemIDplus] xref: Beilstein:25191 {source="Beilstein"} xref: Beilstein:5282047 {source="Beilstein"} xref: CAS:20350-15-6 {source="ChemIDplus"} is_a: CHEBI:25105 ! macrolide antibiotic relationship: RO:0000087 CHEBI:76964 ! has role Penicillium metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H24O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KQNZDYYTLMIZCT-KQPMLPITSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "280.35936" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "280.16746" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C[C@H](O)C[C@@]1([H])[C@H](O)\\C=C\\C(=O)O[C@@H](C)CCC\\C=C\\2" xsd:string [Term] id: CHEBI:4811 name: epoxiconazole namespace: chebi_ontology def: "A racemate composed of equimolar amounts of (2S,3R)- and (2R,3S)-epoxiconazole. A broad-spectrum fungicide for control of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes. Epoxiconazole is moderately toxic to birds, honeybees, earthworms and most aquatic organisms." [] subset: 3_STAR synonym: "(2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole" RELATED [Alan_Wood's_Pesticides] synonym: "rac-1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] synonym: "rel-1-[[(2R,3S)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole" RELATED [Alan_Wood's_Pesticides] xref: CAS:133855-98-8 {source="KEGG COMPOUND"} xref: CAS:133855-98-8 {source="ChemIDplus"} xref: KEGG:C11229 xref: Pesticides:epoxiconazole {source="Alan Wood's Pesticides"} xref: PMID:24274332 {source="Europe PMC"} xref: PMID:24364671 {source="Europe PMC"} xref: PMID:24550150 {source="Europe PMC"} xref: Reaxys:8150613 {source="Reaxys"} xref: Wikipedia:Epoxiconazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: has_part CHEBI:83759 ! (2S,3R)-epoxiconazole relationship: has_part CHEBI:83761 ! (2R,3S)-epoxiconazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H13ClFN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "329.75600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "329.07312" xsd:string [Term] id: CHEBI:48121 name: polyene namespace: chebi_ontology def: "An olefin that contains more than one carbon-carbon double bond." [] subset: 3_STAR synonym: "polyenes" RELATED [ChEBI] is_a: CHEBI:33641 ! olefin [Term] id: CHEBI:48132 name: tetracenomycin namespace: chebi_ontology def: "A polyketide based on a tetracene ring structure." [] subset: 3_STAR synonym: "tetracenomycins" RELATED [ChEBI] is_a: CHEBI:26188 ! polyketide relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:48154 name: sulfur oxide namespace: chebi_ontology subset: 3_STAR synonym: "oxides of sulfur" RELATED [ChEBI] synonym: "Schwefeloxide" RELATED [ChEBI] synonym: "sulfur oxides" RELATED [ChEBI] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:48219 name: disinfectant namespace: chebi_ontology def: "An antimicrobial agent that is applied to non-living objects to destroy harmful microorganisms or to inhibit their activity." [] subset: 3_STAR synonym: "desinfectant" RELATED [ChEBI] synonym: "Desinfektionsmittel" RELATED [ChEBI] synonym: "disinfectants" RELATED [ChEBI] synonym: "disinfecting agent" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:48336 name: (2R,4S)-ketoconazole namespace: chebi_ontology def: "A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2R,4S)-configuration." [] subset: 3_STAR synonym: "(2R,4S)-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" RELATED [ChEBI] synonym: "(2R,4S)-ketoconazole" EXACT [UniProt] synonym: "1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:4241048 {source="Beilstein"} xref: LINCS:LSM-5430 xref: PDBeChem:KKK xref: Reaxys:4241048 {source="Reaxys"} is_a: CHEBI:86411 ! cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine relationship: is_enantiomer_of CHEBI:47518 ! (2S,4R)-ketoconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H28Cl2N4O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XMAYWYJOQHXEEK-OZXSUGGESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "531.43100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "530.14876" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)N1CCN(CC1)c1ccc(OC[C@H]2CO[C@@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1" xsd:string [Term] id: CHEBI:48339 name: 1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine namespace: chebi_ontology def: "A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively." [] subset: 3_STAR synonym: "1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:634785 {source="Beilstein"} xref: DrugBank:DB01026 xref: LINCS:LSM-5148 is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:25698 ! ether is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:46844 ! N-acylpiperazine is_a: CHEBI:46848 ! N-arylpiperazine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H28Cl2N4O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XMAYWYJOQHXEEK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "531.43048" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "530.14876" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)N1CCN(CC1)c1ccc(OCC2COC(Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1" xsd:string [Term] id: CHEBI:48343 name: disulfide namespace: chebi_ontology def: "Compounds of structure RSSR'." [] subset: 3_STAR synonym: "disulfides" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:48354 name: polar solvent namespace: chebi_ontology def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." [] subset: 3_STAR synonym: "polar solvent" EXACT IUPAC_NAME [IUPAC] synonym: "polar solvents" RELATED [ChEBI] is_a: CHEBI:46787 ! solvent [Term] id: CHEBI:48355 name: non-polar solvent namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:46787 ! solvent [Term] id: CHEBI:48356 name: protic solvent namespace: chebi_ontology def: "A polar solvent that is capable of acting as a hydron (proton) donor." [] subset: 3_STAR synonym: "protogenic solvent" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:39141 ! Bronsted acid is_a: CHEBI:48354 ! polar solvent [Term] id: CHEBI:48359 name: protophilic solvent namespace: chebi_ontology def: "Solvent that is capable of acting as a hydron (proton) acceptor." [] subset: 3_STAR synonym: "HBA solvent" RELATED [ChEBI] synonym: "hydrogen bond acceptor solvent" RELATED [ChEBI] synonym: "protophilic solvent" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:39142 ! Bronsted base is_a: CHEBI:48354 ! polar solvent [Term] id: CHEBI:48360 name: amphiprotic solvent namespace: chebi_ontology def: "Self-ionizing solvent possessing both characteristics of Bronsted acids and bases." [] subset: 3_STAR synonym: "amphiprotic solvent" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:48356 ! protic solvent is_a: CHEBI:48359 ! protophilic solvent [Term] id: CHEBI:48376 name: carbamimidic acid namespace: chebi_ontology subset: 3_STAR synonym: "carbamimic acid" RELATED [ChemIDplus] synonym: "carbamimidic acid" EXACT IUPAC_NAME [IUPAC] synonym: "carbonamidimidic acid" RELATED [IUPAC] synonym: "H2N-C(=NH)-OH" RELATED [IUPAC] synonym: "H2N-C(OH)=NH" RELATED [IUPAC] synonym: "HO-C(=NH)-NH2" RELATED [IUPAC] synonym: "Isoharnstoff" RELATED [ChEBI] synonym: "isourea" RELATED [ChemIDplus] synonym: "pseudourea" RELATED [ChemIDplus] xref: Beilstein:773698 {source="Beilstein"} xref: CAS:4744-36-9 {source="ChemIDplus"} is_a: CHEBI:48379 ! isourea is_a: CHEBI:64708 ! one-carbon compound relationship: is_tautomer_of CHEBI:16199 ! urea property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XSQUKJJJFZCRTK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.05534" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.03236" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(O)=N" xsd:string [Term] id: CHEBI:48377 name: imidic acid namespace: chebi_ontology def: "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH)." [] subset: 3_STAR synonym: "imidic acid" EXACT [ChEBI] synonym: "imidic acids" EXACT IUPAC_NAME [IUPAC] synonym: "imidic acids" RELATED [ChEBI] synonym: "imino acids" RELATED [IUPAC] is_a: CHEBI:33241 ! oxoacid derivative is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:48378 name: carboximidic acid namespace: chebi_ontology subset: 3_STAR synonym: "carboximidic acid" EXACT [ChEBI] synonym: "carboximidic acids" EXACT IUPAC_NAME [IUPAC] synonym: "carboximidic acids" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:48377 ! imidic acid [Term] id: CHEBI:48379 name: isourea namespace: chebi_ontology def: "A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives." [] subset: 3_STAR synonym: "isoureas" EXACT IUPAC_NAME [IUPAC] synonym: "isoureas" RELATED [ChEBI] is_a: CHEBI:48378 ! carboximidic acid [Term] id: CHEBI:48422 name: angiogenesis inhibitor namespace: chebi_ontology alt_id: CHEBI:67170 def: "An agent and endogenous substances that antagonize or inhibit the development of new blood vessels." [] subset: 3_STAR synonym: "angiogenesis antagonist" RELATED [ChEBI] synonym: "angiostatic agents" RELATED [ChEBI] synonym: "anti-angiogenic agent" RELATED [ChEBI] xref: Wikipedia:Angiogenesis_inhibitor is_a: CHEBI:23888 ! drug [Term] id: CHEBI:48535 name: aryloxypyrimidine namespace: chebi_ontology subset: 3_STAR synonym: "aryloxypyrimidines" RELATED [ChEBI] is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:48589 name: piperidones namespace: chebi_ontology subset: 3_STAR synonym: "piperidone" RELATED [ChEBI] is_a: CHEBI:26151 ! piperidines is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:48626 name: pyranoindolizinoquinoline namespace: chebi_ontology subset: 3_STAR synonym: "pyranoindolizinoquinolines" RELATED [ChEBI] is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38164 ! organic heteropentacyclic compound [Term] id: CHEBI:48705 name: agonist namespace: chebi_ontology def: "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." [] subset: 3_STAR synonym: "agonist" EXACT IUPAC_NAME [IUPAC] synonym: "agonista" RELATED [ChEBI] synonym: "agoniste" RELATED [ChEBI] synonym: "agonists" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:48706 name: antagonist namespace: chebi_ontology def: "Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances." [] subset: 3_STAR synonym: "antagonist" EXACT IUPAC_NAME [IUPAC] synonym: "antagonista" RELATED [ChEBI] synonym: "antagoniste" RELATED [ChEBI] synonym: "antagonists" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:4877 name: ethambutol namespace: chebi_ontology alt_id: CHEBI:133410 alt_id: CHEBI:659237 alt_id: CHEBI:678172 def: "An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone." [] subset: 3_STAR synonym: "(+)-2,2'-(ethylenediimino)di-1-butanol" RELATED [ChemIDplus] synonym: "(+)-ethambutol" RELATED [ChEBI] synonym: "(+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine" RELATED [ChemIDplus] synonym: "(+)-S,S-ethambutol" RELATED [ChemIDplus] synonym: "(2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol" EXACT IUPAC_NAME [IUPAC] synonym: "(2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol" RELATED [ChEBI] synonym: "(S,S)-ethambutol" RELATED [ChEBI] synonym: "EMB" RELATED [ChEBI] synonym: "etambutol" RELATED INN [ChemIDplus] synonym: "Ethambutol" EXACT [KEGG_COMPOUND] synonym: "ethambutol" RELATED INN [ChemIDplus] synonym: "ethambutolum" RELATED INN [ChemIDplus] synonym: "S,S-Ethambutol" RELATED [ChEMBL] xref: Beilstein:6312870 {source="Beilstein"} xref: CAS:74-55-5 {source="ChemIDplus"} xref: CAS:74-55-5 {source="KEGG COMPOUND"} xref: Drug_Central:1073 {source="DrugCentral"} xref: DrugBank:DB00330 xref: KEGG:C06984 xref: KEGG:D07925 xref: PMID:10649975 {source="ChEMBL"} xref: PMID:10891117 {source="ChEMBL"} xref: PMID:10966749 {source="ChEMBL"} xref: PMID:12182855 {source="ChEMBL"} xref: PMID:14695841 {source="ChEMBL"} xref: PMID:14698152 {source="ChEMBL"} xref: PMID:15225698 {source="ChEMBL"} xref: PMID:16005211 {source="ChEMBL"} xref: PMID:16759086 {source="ChEMBL"} xref: PMID:16870429 {source="ChEMBL"} xref: PMID:17210775 {source="ChEMBL"} xref: PMID:17239593 {source="ChEMBL"} xref: PMID:17276683 {source="ChEMBL"} xref: PMID:17315960 {source="ChEMBL"} xref: PMID:17331717 {source="ChEMBL"} xref: PMID:17562368 {source="ChEMBL"} xref: PMID:17851083 {source="ChEMBL"} xref: PMID:17888665 {source="ChEMBL"} xref: PMID:19524332 {source="ChEMBL"} xref: PMID:19648006 {source="ChEMBL"} xref: PMID:3934384 {source="ChEMBL"} xref: Reaxys:6312870 {source="Reaxys"} xref: Wikipedia:Ethambutol is_a: CHEBI:23981 ! ethanolamines is_a: CHEBI:31577 ! ethylenediamine derivative relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H24N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AEUTYOVWOVBAKS-UWVGGRQHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "204.30980" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "204.18378" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H](CO)NCCN[C@@H](CC)CO" xsd:string [Term] id: CHEBI:48819 name: cyano group namespace: chebi_ontology alt_id: CHEBI:36824 alt_id: CHEBI:48818 subset: 3_STAR synonym: "-C#N" RELATED [IUPAC] synonym: "-CN" RELATED [IUPAC] synonym: "carbonitrile group" RELATED [ChEBI] synonym: "CYANIDE GROUP" RELATED [PDBeChem] synonym: "cyanido" EXACT IUPAC_NAME [IUPAC] synonym: "cyano" EXACT IUPAC_NAME [IUPAC] synonym: "NC-" RELATED [IUPAC] xref: PDBeChem:CYN is_a: CHEBI:36823 ! pseudohalo group relationship: is_substituent_group_from CHEBI:18407 ! hydrogen cyanide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CN" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "26.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "26.00307" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(#N)*" xsd:string [Term] id: CHEBI:48848 name: erythronolide A namespace: chebi_ontology subset: 3_STAR synonym: "(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-4,6,7,12,13-pentahydroxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione" EXACT IUPAC_NAME [IUPAC] synonym: "Erythronolid A" RELATED [ChEBI] xref: Beilstein:4570921 {source="Beilstein"} xref: CAS:26754-37-0 {source="ChemIDplus"} is_a: CHEBI:23955 ! erythronolide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H38O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H38O8/c1-8-14-21(7,28)18(25)11(3)15(22)10(2)9-20(6,27)17(24)12(4)16(23)13(5)19(26)29-14/h10-14,16-18,23-25,27-28H,8-9H2,1-7H3/t10-,11+,12+,13-,14-,16+,17-,18-,20-,21-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YVTFLQUPRIIRFE-QUMKBVJLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "418.52162" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "418.25667" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O" xsd:string [Term] id: CHEBI:4885 name: ethionamide namespace: chebi_ontology def: "A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide." [] subset: 3_STAR synonym: "2-ethyl-4-thiopyridylamide" RELATED [ChEBI] synonym: "2-ethylpyridine-4-carbothioamide" EXACT IUPAC_NAME [IUPAC] synonym: "ETH" RELATED [DrugBank] synonym: "Ethinamide" RELATED [DrugBank] synonym: "Ethionamide" EXACT [KEGG_COMPOUND] synonym: "ethionamide" EXACT [UniProt] synonym: "ethionamidum" RELATED INN [ChemIDplus] synonym: "Ethioniamide" RELATED [DrugBank] synonym: "Ethylisothiamide" RELATED [DrugBank] synonym: "Ethyonomide" RELATED [DrugBank] synonym: "Etionamid" RELATED [DrugBank] synonym: "etionamida" RELATED INN [ChemIDplus] synonym: "Etionamide" RELATED [DrugBank] synonym: "Etioniamid" RELATED [DrugBank] synonym: "ETP" RELATED [DrugBank] synonym: "Trecator" RELATED BRAND_NAME [ChemIDplus] xref: Beilstein:116474 {source="Beilstein"} xref: CAS:536-33-4 {source="NIST Chemistry WebBook"} xref: CAS:536-33-4 {source="ChemIDplus"} xref: CAS:536-33-4 {source="KEGG COMPOUND"} xref: Drug_Central:1083 {source="DrugCentral"} xref: DrugBank:DB00609 xref: HMDB:HMDB0014747 xref: KEGG:C07665 xref: KEGG:D00591 xref: LINCS:LSM-5620 xref: Patent:GB800250 xref: PMID:14651620 {source="Europe PMC"} xref: PMID:15673755 {source="Europe PMC"} xref: PMID:15850780 {source="Europe PMC"} xref: Reaxys:116474 {source="Reaxys"} xref: Wikipedia:Ethionamide is_a: CHEBI:26421 ! pyridines is_a: CHEBI:47956 ! thiocarboxamide relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35679 ! has role antilipemic drug relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug relationship: RO:0000087 CHEBI:50185 ! has role fatty acid synthesis inhibitor relationship: RO:0000087 CHEBI:50266 ! has role prodrug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H10N2S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AEOCXXJPGCBFJA-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "166.24448" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.05647" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCc1cc(ccn1)C(N)=S" xsd:string [Term] id: CHEBI:48854 name: sulfurous acid namespace: chebi_ontology alt_id: CHEBI:26837 alt_id: CHEBI:9344 subset: 3_STAR synonym: "[SO(OH)2]" RELATED [IUPAC] synonym: "acide sulfureux" RELATED [ChEBI] synonym: "acido sulfuroso" RELATED [ChEBI] synonym: "dihydrogen trioxosulfate" EXACT IUPAC_NAME [IUPAC] synonym: "dihydroxidooxidosulfur" EXACT IUPAC_NAME [IUPAC] synonym: "H2SO3" RELATED [IUPAC] synonym: "S(O)(OH)2" RELATED [IUPAC] synonym: "schweflige Saeure" RELATED [ChemIDplus] synonym: "Sulfite" RELATED [KEGG_COMPOUND] synonym: "Sulfurous acid" EXACT [KEGG_COMPOUND] synonym: "sulfurous acid" EXACT IUPAC_NAME [IUPAC] synonym: "sulphurous acid" RELATED [ChemIDplus] synonym: "trioxosulfuric acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:7782-99-2 {source="ChemIDplus"} xref: Gmelin:1458 {source="Gmelin"} xref: KEGG:C00094 xref: KNApSAcK:C00019662 xref: PDBeChem:SO3 xref: UM-BBD_compID:c0348 {source="UM-BBD"} is_a: CHEBI:33402 ! sulfur oxoacid relationship: is_conjugate_acid_of CHEBI:17137 ! hydrogensulfite relationship: is_tautomer_of CHEBI:29214 ! sulfonic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "82.08008" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.97247" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS(O)=O" xsd:string [Term] id: CHEBI:48891 name: thiazolidinone namespace: chebi_ontology subset: 3_STAR synonym: "thiazolidinones" RELATED [ChEBI] is_a: CHEBI:35622 ! thiazolidines [Term] id: CHEBI:48901 name: thiazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom." [] subset: 3_STAR synonym: "thiazole" RELATED [ChEBI] is_a: CHEBI:38106 ! organosulfur heterocyclic compound is_a: CHEBI:68452 ! azole [Term] id: CHEBI:48908 name: triazolobenzothiazole namespace: chebi_ontology subset: 3_STAR synonym: "triazolobenzothiazoles" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:48923 name: erythromycin namespace: chebi_ontology def: "Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus)." [] subset: 3_STAR synonym: "eritromicina" RELATED [ChEBI] synonym: "erthromycin" RELATED [ChEBI] synonym: "erythromycine" RELATED [ChEBI] xref: DrugBank:DB00199 xref: HMDB:HMDB0014344 xref: Patent:US2653899 xref: Wikipedia:Erythromycin is_a: CHEBI:23953 ! erythromycins relationship: is_conjugate_acid_of CHEBI:64290 ! erythromycin cation relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:48960 name: bis(azo) compound namespace: chebi_ontology def: "Any azo compound containing two -N=N- groups." [] subset: 3_STAR synonym: "bis(azo) compound" EXACT IUPAC_NAME [IUPAC] synonym: "bis(azo) compounds" RELATED [ChEBI] is_a: CHEBI:37533 ! azo compound [Term] id: CHEBI:48975 name: substituted aniline namespace: chebi_ontology subset: 3_STAR synonym: "substituted anilines" RELATED [ChEBI] is_a: CHEBI:22562 ! anilines [Term] id: CHEBI:49020 name: hormone antagonist namespace: chebi_ontology def: "A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." [] subset: 3_STAR synonym: "hormone antagonists" RELATED [ChEBI] is_a: CHEBI:48706 ! antagonist is_a: CHEBI:51061 ! hormone receptor modulator [Term] id: CHEBI:49103 name: drug metabolite namespace: chebi_ontology subset: 3_STAR synonym: "drug metabolites" RELATED [ChEBI] is_a: CHEBI:76967 ! human xenobiotic metabolite [Term] id: CHEBI:49167 name: anti-asthmatic drug namespace: chebi_ontology def: "A drug used to treat asthma." [] subset: 3_STAR synonym: "anti-asthmatic agent" RELATED [ChEBI] synonym: "anti-asthmatic agents" RELATED [ChEBI] synonym: "anti-asthmatic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:65023 ! anti-asthmatic agent [Term] id: CHEBI:49318 name: piperidine antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:26151 ! piperidines [Term] id: CHEBI:49319 name: carbocyclic antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33598 ! carbocyclic compound relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:49637 name: hydrogen atom namespace: chebi_ontology alt_id: CHEBI:24634 alt_id: CHEBI:49636 subset: 3_STAR synonym: "1H" RELATED [IUPAC] synonym: "H" RELATED [IUPAC] synonym: "hidrogeno" RELATED [ChEBI] synonym: "hydrogen" EXACT IUPAC_NAME [IUPAC] synonym: "hydrogen" RELATED [ChEBI] synonym: "hydrogene" RELATED [ChEBI] synonym: "Wasserstoff" RELATED [ChEBI] xref: WebElements:H is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33559 ! s-block element atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YZCKVEUIGOORGS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1.00794" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.00783" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]" xsd:string [Term] id: CHEBI:4998 name: fenarimol namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union." [] subset: 3_STAR synonym: "(+-)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol" RELATED [ChemIDplus] synonym: "(+-)-fenarimol" RELATED [HMDB] synonym: "(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol" RELATED [NIST_Chemistry_WebBook] synonym: "(RS)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol" RELATED [Alan_Wood's_Pesticides] synonym: "2,4'-dichloro-alpha(pyrimidin-5-yl)benzhydryl alcohol" RELATED [NIST_Chemistry_WebBook] synonym: "alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol" RELATED [Alan_Wood's_Pesticides] synonym: "EL 222" RELATED BRAND_NAME [NIST_Chemistry_WebBook] synonym: "fenarimol" EXACT [ChEBI] synonym: "rac-(2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol" EXACT IUPAC_NAME [IUPAC] synonym: "rac-(R)-(2-chlorophenyl)(4-chlorophenyl)(pyrimidin-5-yl)methanol" RELATED [Alan_Wood's_Pesticides] synonym: "rac-fenarimol" RELATED [ChEBI] synonym: "Rimidin" RELATED BRAND_NAME [NIST_Chemistry_WebBook] synonym: "Rubigan" RELATED BRAND_NAME [NIST_Chemistry_WebBook] xref: CAS:60168-88-9 {source="ChemIDplus"} xref: CAS:60168-88-9 {source="NIST Chemistry WebBook"} xref: CAS:60168-88-9 {source="KEGG COMPOUND"} xref: CAS:60168-88-9 {source="Alan Wood's Pesticides"} xref: HMDB:HMDB0040599 xref: KEGG:C11226 xref: Patent:US3818009 xref: Patent:US3869456 xref: Patent:US3887708 xref: Pesticides:fenarimol {source="Alan Wood's Pesticides"} xref: PMID:12146625 {source="Europe PMC"} xref: PMID:14700530 {source="Europe PMC"} xref: PMID:15866470 {source="Europe PMC"} xref: PMID:18372651 {source="Europe PMC"} xref: PMID:22955670 {source="Europe PMC"} xref: PMID:23664474 {source="Europe PMC"} xref: PMID:8637508 {source="Europe PMC"} xref: Reaxys:5972869 {source="Reaxys"} xref: Wikipedia:Fenarimol is_a: CHEBI:60911 ! racemate is_a: CHEBI:87207 ! pyrimidine fungicide relationship: has_part CHEBI:83688 ! (R)-fenarimol relationship: has_part CHEBI:83689 ! (S)-fenarimol relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H12Cl2N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "331.19600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "330.03267" xsd:string [Term] id: CHEBI:50010 name: 4,4'-bis(\{4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl\}amino)stilbene-2,2'-disulfonic acid namespace: chebi_ontology def: "An organosulfonic acid comprising stilbene having 4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino groups at the 4 and 4'-positions and sulfo groups at the 2- and 2'-positions." [] subset: 3_STAR synonym: "2,2'-ethene-1,2-diylbis[5-({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonic acid]" EXACT IUPAC_NAME [IUPAC] synonym: "4,4'-bis((4-(bis(2-hydroxyethyl)amino)-6-anilino-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulphonic acid" RELATED [ChemIDplus] synonym: "4,4'-bis((4-anilino-6-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulfonic acid" RELATED [ChemIDplus] synonym: "4,4'-bis((4-anilino-6-(bis(2-hydroxyethyl)amino)-s-triazin-2-yl)amino)-2,2'-stilbenedisulfonic acid" RELATED [ChemIDplus] synonym: "C.I. Fluorescent brightening agent 28" RELATED [ChemIDplus] synonym: "Calcofluor M2R" RELATED [ChemIDplus] synonym: "Calcofluor White M2R" RELATED [ChemIDplus] xref: Beilstein:604239 {source="Beilstein"} xref: CAS:4404-43-7 {source="ChemIDplus"} xref: PMID:11015407 {source="Europe PMC"} xref: PMID:15038150 {source="Europe PMC"} xref: PMID:17252623 {source="Europe PMC"} xref: PMID:2580370 {source="Europe PMC"} xref: PMID:3061981 {source="Europe PMC"} xref: PMID:7181601 {source="Europe PMC"} xref: Reaxys:8385272 {source="Reaxys"} is_a: CHEBI:26588 ! 1,3,5-triazines is_a: CHEBI:33551 ! organosulfonic acid relationship: has_parent_hydride CHEBI:26775 ! stilbene relationship: is_conjugate_acid_of CHEBI:50012 ! 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonate relationship: RO:0000087 CHEBI:51217 ! has role fluorochrome property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C40H44N12O10S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C40H44N12O10S2/c53-21-17-51(18-22-54)39-47-35(41-29-7-3-1-4-8-29)45-37(49-39)43-31-15-13-27(33(25-31)63(57,58)59)11-12-28-14-16-32(26-34(28)64(60,61)62)44-38-46-36(42-30-9-5-2-6-10-30)48-40(50-38)52(19-23-55)20-24-56/h1-16,25-26,53-56H,17-24H2,(H,57,58,59)(H,60,61,62)(H2,41,43,45,47,49)(H2,42,44,46,48,50)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CNGYZEMWVAWWOB-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "916.98424" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "916.27448" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=C([H])c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S(O)(=O)=O)c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S(O)(=O)=O" xsd:string [Term] id: CHEBI:50011 name: Calcofluor White namespace: chebi_ontology subset: 3_STAR synonym: "4,4'-bis((2-anilino-4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-6-yl)amino)stilbene-2,2'-disulfonic acid, disodium salt" RELATED [ChemIDplus] synonym: "4,4'-bis((4-anilino-6-bis(2-hydroxyethyl)amino-s-triazin-2-yl)amino)-2,2'-stilbenedisulfonic acid, disodium salt" RELATED [ChemIDplus] synonym: "C.I. 40622" RELATED [ChEBI] synonym: "C.I. Fluorescent Brightening Agent 28, disodium salt" RELATED [ChemIDplus] synonym: "Calcofluor White LRP" RELATED [ChemIDplus] synonym: "Calcofluor White M 2R" RELATED [ChemIDplus] synonym: "Calcofluor White ST" RELATED [ChemIDplus] synonym: "Cellufluor" RELATED [ChemIDplus] synonym: "disodium 2,2'-ethene-1,2-diylbis[5-({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]" EXACT IUPAC_NAME [IUPAC] synonym: "disodium 4,4'-bis(6-anilino-(4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulphonate" RELATED [ChemIDplus] synonym: "Fluorescent Brightener 28" RELATED [ChemIDplus] xref: Beilstein:8385272 {source="Beilstein"} xref: CAS:4193-55-9 {source="ChemIDplus"} is_a: CHEBI:38700 ! organic sodium salt relationship: has_part CHEBI:50012 ! 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonate property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C40H42N12Na2O10S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C40H44N12O10S2.2Na/c53-21-17-51(18-22-54)39-47-35(41-29-7-3-1-4-8-29)45-37(49-39)43-31-15-13-27(33(25-31)63(57,58)59)11-12-28-14-16-32(26-34(28)64(60,61)62)44-38-46-36(42-30-9-5-2-6-10-30)48-40(50-38)52(19-23-55)20-24-56;;/h1-16,25-26,53-56H,17-24H2,(H,57,58,59)(H,60,61,62)(H2,41,43,45,47,49)(H2,42,44,46,48,50);;/q;2*+1/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YJHDFAAFYNRKQE-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "960.94790" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "960.23837" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na+].[Na+].[H]C(=C([H])c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S([O-])(=O)=O)c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S([O-])(=O)=O" xsd:string [Term] id: CHEBI:50012 name: 4,4'-bis(\{4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl\}amino)stilbene-2,2'-disulfonate namespace: chebi_ontology def: "An arenesulfonate arising from deprotonation of the sulfo groups of 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonic acid." [] subset: 3_STAR synonym: "2,2'-ethene-1,2-diylbis[5-({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:22713 ! arenesulfonate oxoanion relationship: has_parent_hydride CHEBI:26775 ! stilbene relationship: is_conjugate_base_of CHEBI:50010 ! 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C40H42N12O10S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C40H44N12O10S2/c53-21-17-51(18-22-54)39-47-35(41-29-7-3-1-4-8-29)45-37(49-39)43-31-15-13-27(33(25-31)63(57,58)59)11-12-28-14-16-32(26-34(28)64(60,61)62)44-38-46-36(42-30-9-5-2-6-10-30)48-40(50-38)52(19-23-55)20-24-56/h1-16,25-26,53-56H,17-24H2,(H,57,58,59)(H,60,61,62)(H2,41,43,45,47,49)(H2,42,44,46,48,50)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CNGYZEMWVAWWOB-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "914.96836" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "914.25993" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=C([H])c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S([O-])(=O)=O)c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S([O-])(=O)=O" xsd:string [Term] id: CHEBI:50047 name: organic amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "organic amino compounds" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: has_parent_hydride CHEBI:16134 ! ammonia relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base [Term] id: CHEBI:50103 name: excitatory amino acid agonist namespace: chebi_ontology def: "An agent that binds to and activates excitatory amino acid receptors." [] subset: 3_STAR synonym: "excitatory amino acid agonists" RELATED [ChEBI] synonym: "excitatory amino acid receptor agonist" RELATED [ChEBI] synonym: "excitatory amino acid receptor agonists" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:50160 name: steroid acid anion namespace: chebi_ontology def: "Any anion formed by loss of a proton from a steroid acid." [] subset: 3_STAR synonym: "steroid acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid [Term] id: CHEBI:50176 name: keratolytic drug namespace: chebi_ontology def: "A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases." [] subset: 3_STAR synonym: "desquamating agent" RELATED [ChEBI] synonym: "keratolytic agent" RELATED [ChEBI] synonym: "keratolytic drugs" RELATED [ChEBI] synonym: "skin-peeling agent" RELATED [ChEBI] is_a: CHEBI:50177 ! dermatologic drug [Term] id: CHEBI:50177 name: dermatologic drug namespace: chebi_ontology def: "A drug used to treat or prevent skin disorders or for the routine care of skin." [] subset: 3_STAR synonym: "dermatologic agent" RELATED [ChEBI] synonym: "dermatologic drugs" RELATED [ChEBI] synonym: "dermatological agent" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50183 name: P450 inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances." [] subset: 3_STAR synonym: "CYP2D6 inhibitor" RELATED [ChEBI] synonym: "CYP2D6 inhibitors" RELATED [ChEBI] synonym: "cytochrome P450 inhibitor" RELATED [ChEBI] synonym: "cytochrome P450 inhibitors" RELATED [ChEBI] synonym: "P450 inhibitors" RELATED [ChEBI] is_a: CHEBI:76898 ! EC 1.14.14.1 (unspecific monooxygenase) inhibitor [Term] id: CHEBI:50185 name: fatty acid synthesis inhibitor namespace: chebi_ontology def: "Any pathway inhibitor that inhibits the synthesis of fatty acids." [] subset: 3_STAR synonym: "fatty acid synthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:50247 name: antidote namespace: chebi_ontology def: "Any protective agent counteracting or neutralizing the action of poisons." [] subset: 3_STAR synonym: "antidotes" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:50248 name: hematologic agent namespace: chebi_ontology def: "Drug that acts on blood and blood-forming organs and those that affect the hemostatic system." [] subset: 3_STAR synonym: "hematologic agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50249 name: anticoagulant namespace: chebi_ontology def: "An agent that prevents blood clotting." [] subset: 3_STAR synonym: "anticoagulante" RELATED [ChEBI] synonym: "anticoagulants" RELATED [ChEBI] is_a: CHEBI:50248 ! hematologic agent [Term] id: CHEBI:50266 name: prodrug namespace: chebi_ontology def: "A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug." [] subset: 3_STAR synonym: "Prodrugs" RELATED [ChEBI] xref: PMID:23993918 {source="Europe PMC"} xref: PMID:23998799 {source="Europe PMC"} xref: PMID:24329110 {source="Europe PMC"} xref: PMID:24628402 {source="Europe PMC"} xref: PMID:24709544 {source="Europe PMC"} xref: PMID:25144792 {source="Europe PMC"} xref: PMID:25157234 {source="Europe PMC"} xref: PMID:25269430 {source="Europe PMC"} xref: PMID:25391982 {source="Europe PMC"} xref: PMID:25591121 {source="Europe PMC"} xref: PMID:25620096 {source="Europe PMC"} xref: PMID:25795057 {source="Europe PMC"} xref: PMID:26028253 {source="Europe PMC"} xref: PMID:26184144 {source="Europe PMC"} xref: PMID:28070577 {source="Europe PMC"} xref: PMID:28215138 {source="Europe PMC"} xref: PMID:28219047 {source="Europe PMC"} xref: PMID:28259775 {source="Europe PMC"} xref: PMID:28319647 {source="Europe PMC"} xref: PMID:28329729 {source="Europe PMC"} xref: PMID:28334528 {source="Europe PMC"} xref: Wikipedia:Prodrug is_a: CHEBI:136859 ! pro-agent is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50267 name: protective agent namespace: chebi_ontology def: "Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent." [] subset: 3_STAR synonym: "chemoprotectant" RELATED [ChEBI] synonym: "chemoprotectants" RELATED [ChEBI] synonym: "chemoprotective agent" RELATED [ChEBI] synonym: "chemoprotective agents" RELATED [ChEBI] synonym: "protective agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50276 name: EC 5.99.1.2 (DNA topoisomerase) inhibitor namespace: chebi_ontology def: "A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA." [] subset: 3_STAR synonym: "DNA topoisomerase inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.2 (DNA topoisomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.2 (topoisomerase I) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.2 (topoisomerase I) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.2 inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.2 inhibitors" RELATED [ChEBI] synonym: "topoisomerase I (EC 5.99.1.2) inhibitor" RELATED [ChEBI] synonym: "topoisomerase I (EC 5.99.1.2) inhibitors" RELATED [ChEBI] synonym: "topoisomerase I inhibitor" RELATED [ChEBI] synonym: "topoisomerase I inhibitors" RELATED [ChEBI] synonym: "type I DNA topoisomerase inhibitor" RELATED [ChEBI] synonym: "type I DNA topoisomerase inhibitors" RELATED [ChEBI] is_a: CHEBI:70727 ! topoisomerase inhibitor [Term] id: CHEBI:50297 name: canonical nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleotide residues" RELATED [ChEBI] is_a: CHEBI:50319 ! nucleotide residue [Term] id: CHEBI:50299 name: canonical ribonucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleotide residues" RELATED [ChEBI] is_a: CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:50312 name: onium compound namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:50313 name: onium cation namespace: chebi_ontology def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." [] subset: 3_STAR synonym: "onium cations" EXACT IUPAC_NAME [IUPAC] synonym: "onium cations" RELATED [ChEBI] synonym: "onium ion" RELATED [ChEBI] synonym: "onium ions" RELATED [ChEBI] is_a: CHEBI:50312 ! onium compound [Term] id: CHEBI:50315 name: chloronium namespace: chebi_ontology subset: 3_STAR synonym: "[ClH2](+)" RELATED [IUPAC] synonym: "chloranium" EXACT IUPAC_NAME [IUPAC] synonym: "chloronium" EXACT IUPAC_NAME [IUPAC] synonym: "H2Cl(+)" RELATED [IUPAC] xref: Gmelin:331 {source="Gmelin"} is_a: CHEBI:50313 ! onium cation relationship: is_conjugate_acid_of CHEBI:17883 ! hydrogen chloride property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "ClH2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/ClH2/h1H2/q+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IGJWHVUMEJASKV-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "37.46858" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "36.98395" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][Cl+][H]" xsd:string [Term] id: CHEBI:50319 name: nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleotide residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50320 name: nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleoside residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50325 name: proteinogenic amino-acid side-chain group namespace: chebi_ontology def: "A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid." [] subset: 3_STAR synonym: "canonical amino-acid side-chain" RELATED [ChEBI] synonym: "canonical amino-acid side-chains" RELATED [ChEBI] synonym: "proteinogenic amino-acid side-chain" RELATED [ChEBI] synonym: "proteinogenic amino-acid side-chain groups" RELATED [ChEBI] synonym: "proteinogenic amino-acid side-chains" RELATED [ChEBI] is_a: CHEBI:33249 ! organyl group [Term] id: CHEBI:50335 name: organic nitrogen anion namespace: chebi_ontology subset: 3_STAR synonym: "organic nitrogen anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:50344 name: avermectin namespace: chebi_ontology def: "Any of the macrolides obtained as fermentation products from the bacterium Streptomyces avermitilis and consisting of a 16-membered macrocyclic backbone that is fused both benzofuran and spiroketal functions and contains a disaccharide substituent. They have significant anthelmintic and insecticidal properties." [] subset: 3_STAR synonym: "avermectin" EXACT [ChEBI] synonym: "avermectins" RELATED [ChEBI] xref: PMID:22039784 {source="Europe PMC"} xref: PMID:22039799 {source="Europe PMC"} xref: PMID:22542398 {source="Europe PMC"} xref: PMID:23165468 {source="Europe PMC"} xref: PMID:8688633 {source="Europe PMC"} xref: Wikipedia:Avermectin is_a: CHEBI:25106 ! macrolide is_a: CHEBI:59779 ! cyclic ketal relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:50346 name: emamectins namespace: chebi_ontology subset: 3_STAR synonym: "emamectin" RELATED [ChEBI] is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:50406 name: probe namespace: chebi_ontology def: "A role played by a molecular entity used to study the microscopic environment." [] subset: 3_STAR is_a: CHEBI:33232 ! application [Term] id: CHEBI:50471 name: primary arylamine namespace: chebi_ontology def: "A primary amine formally derived from ammonia by replacing one hydrogen atom by an aryl group. R-NH2 where R is an aryl group." [] subset: 3_STAR synonym: "an arylamine" RELATED [UniProt] synonym: "primary arylamine" EXACT [ChEBI] is_a: CHEBI:32877 ! primary amine is_a: CHEBI:33860 ! aromatic amine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H2NR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "16.023" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01872" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]N(*)[H]" xsd:string [Term] id: CHEBI:50492 name: thiocarbonyl compound namespace: chebi_ontology def: "Any compound containing the thiocarbonyl group, C=S." [] subset: 3_STAR synonym: "thiocarbonyl compounds" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound relationship: has_part CHEBI:30256 ! thiocarbonyl group [Term] id: CHEBI:50525 name: phenolate anion namespace: chebi_ontology def: "An organic anion arising from deprotonation of the OH function of a phenol compound." [] subset: 3_STAR synonym: "phenolate anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion [Term] id: CHEBI:50533 name: protein denaturant namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33232 ! application [Term] id: CHEBI:50584 name: alkyl alcohol namespace: chebi_ontology alt_id: CHEBI:22937 alt_id: CHEBI:50581 def: "An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position." [] subset: 3_STAR synonym: "alkyl alcohols" RELATED [ChEBI] synonym: "hydroxyalkane" RELATED [ChEBI] synonym: "hydroxyalkanes" RELATED [ChEBI] is_a: CHEBI:2571 ! aliphatic alcohol [Term] id: CHEBI:50635 name: EC 3.5.1.5 (urease) inhibitor namespace: chebi_ontology def: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of urease (EC 3.5.1.5), reducing hydrolysis." [] subset: 3_STAR synonym: "EC 3.5.1.5 (urease) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.5 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.5 inhibitors" RELATED [ChEBI] synonym: "urea amidohydrolase inhibitor" RELATED [ChEBI] synonym: "urea amidohydrolase inhibitors" RELATED [ChEBI] synonym: "urease (EC 3.5.1.5) inhibitor" RELATED [ChEBI] synonym: "urease (EC 3.5.1.5) inhibitors" RELATED [ChEBI] synonym: "urease inhibitor" RELATED [ChEBI] synonym: "urease inhibitors" RELATED [ChEBI] is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:50658 name: ampicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "ampicillinate" RELATED [ChEBI] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:28971 ! ampicillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H18N3O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/p-1/t9-,10-,11+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AVKUERGKIZMTKX-NJBDSQKTSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "348.39794" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "348.10235" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C([O-])=O" xsd:string [Term] id: CHEBI:50683 name: EC 1.5.1.3 (dihydrofolate reductase) inhibitor namespace: chebi_ontology def: "An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3)." [] subset: 3_STAR synonym: "7,8-dihydrofolate reductase inhibitor" RELATED [ChEBI] synonym: "7,8-dihydrofolate reductase inhibitors" RELATED [ChEBI] synonym: "DHFR inhibitor" RELATED [ChEBI] synonym: "DHFR inhibitors" RELATED [ChEBI] synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitor" RELATED [ChEBI] synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitors" RELATED [ChEBI] synonym: "dihydrofolate reductase inhibitor" RELATED [ChEBI] synonym: "dihydrofolate reductase inhibitors" RELATED [ChEBI] synonym: "dihydrofolic acid reductase inhibitor" RELATED [ChEBI] synonym: "dihydrofolic acid reductase inhibitors" RELATED [ChEBI] synonym: "dihydrofolic reductase inhibitor" RELATED [ChEBI] synonym: "dihydrofolic reductase inhibitors" RELATED [ChEBI] synonym: "EC 1.5.1.3 (dihydrofolate reductase) inhibitors" RELATED [ChEBI] synonym: "EC 1.5.1.3 inhibitor" RELATED [ChEBI] synonym: "EC 1.5.1.3 inhibitors" RELATED [ChEBI] synonym: "folic acid reductase inhibitor" RELATED [ChEBI] synonym: "folic acid reductase inhibitors" RELATED [ChEBI] synonym: "folic reductase inhibitor" RELATED [ChEBI] synonym: "folic reductase inhibitors" RELATED [ChEBI] synonym: "NADPH-dihydrofolate reductase inhibitor" RELATED [ChEBI] synonym: "NADPH-dihydrofolate reductase inhibitors" RELATED [ChEBI] synonym: "tetrahydrofolate dehydrogenase inhibitor" RELATED [ChEBI] synonym: "tetrahydrofolate dehydrogenase inhibitors" RELATED [ChEBI] xref: Wikipedia:Dihydrofolate_reductase_inhibitor is_a: CHEBI:73913 ! antifolate is_a: CHEBI:76863 ! EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor [Term] id: CHEBI:50685 name: antitrichomonal drug namespace: chebi_ontology def: "A drug used to treat trichomonas infections." [] subset: 3_STAR synonym: "antitrichomonal agent" RELATED [ChEBI] is_a: CHEBI:35820 ! antiprotozoal drug [Term] id: CHEBI:50694 name: minocycline namespace: chebi_ontology alt_id: CHEBI:44053 alt_id: CHEBI:6939 def: "A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5." [] subset: 3_STAR synonym: "(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" RELATED [PDBeChem] synonym: "(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "7-Dimethylamino-6-demethyl-6-deoxytetracycline" RELATED [ChemIDplus] synonym: "minociclina" RELATED INN [DrugBank] synonym: "minociclinum" RELATED INN [DrugBank] synonym: "Minocycline" EXACT [KEGG_COMPOUND] synonym: "minocycline" RELATED INN [ChemIDplus] synonym: "minomycin" RELATED [ChEBI] xref: Beilstein:3077644 {source="Beilstein"} xref: CAS:10118-90-8 {source="ChemIDplus"} xref: CAS:10118-90-8 {source="KEGG COMPOUND"} xref: Chemspider:16735907 xref: Drug_Central:1813 {source="DrugCentral"} xref: DrugBank:DB01017 xref: HMDB:HMDB0015152 xref: KEGG:C07225 xref: KEGG:D05045 xref: KNApSAcK:C00018686 xref: LIPID_MAPS_instance:LMPK07000002 {source="LIPID MAPS"} xref: Patent:US3226436 xref: Patent:WO2008104734 xref: PDBeChem:MIY xref: PMID:22330257 {source="Europe PMC"} xref: PMID:28709717 {source="Europe PMC"} xref: PMID:31630007 {source="Europe PMC"} xref: PMID:31719236 {source="Europe PMC"} xref: PMID:31733348 {source="Europe PMC"} xref: PMID:33568043 {source="Europe PMC"} xref: PMID:34232283 {source="Europe PMC"} xref: PMID:34636517 {source="Europe PMC"} xref: Reaxys:3077644 {source="Reaxys"} is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines is_a: CHEBI:48132 ! tetracenomycin relationship: is_conjugate_acid_of CHEBI:71337 ! minocycline(1-) relationship: is_tautomer_of CHEBI:77906 ! minocycline zwitterion relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27N3O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYKFCLLONBREIL-KVUCHLLUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "457.47650" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "457.18490" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12Cc3c(ccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C" xsd:string [Term] id: CHEBI:50695 name: monobactam namespace: chebi_ontology def: "Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotic. It lacks the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized." [] subset: 3_STAR synonym: "monobactams" RELATED [ChEBI] is_a: CHEBI:27933 ! beta-lactam antibiotic [Term] id: CHEBI:50696 name: EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of peptidoglycan glycosyltransferase (EC 2.4.1.129)." [] subset: 3_STAR synonym: "[poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitor" RELATED [ChEBI] synonym: "[poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitors" RELATED [ChEBI] synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.129 inhibitor" RELATED [ChEBI] synonym: "EC 2.4.1.129 inhibitors" RELATED [ChEBI] synonym: "PBP3 inhibitor" RELATED [ChEBI] synonym: "penicillin binding protein 1B inhibitor" RELATED [ChEBI] synonym: "penicillin binding protein 1B inhibitors" RELATED [ChEBI] synonym: "penicillin binding protein 3 inhibitor" RELATED [ChEBI] synonym: "penicillin binding protein 3 inhibitors" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitor" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitors" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase inhibitor" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase inhibitors" RELATED [ChEBI] synonym: "peptidoglycan transglycosylase inhibitor" RELATED [ChEBI] synonym: "peptidoglycan transglycosylase inhibitors" RELATED [ChEBI] synonym: "PG-II inhibitor" RELATED [ChEBI] synonym: "PG-II inhibitors" RELATED [ChEBI] synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitor" RELATED [ChEBI] synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor [Term] id: CHEBI:50699 name: oligosaccharide namespace: chebi_ontology alt_id: CHEBI:25679 alt_id: CHEBI:35319 alt_id: CHEBI:7758 def: "A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues." [] subset: 3_STAR synonym: "O-glycosylglycoside" RELATED [ChEBI] synonym: "O-glycosylglycosides" RELATED [ChEBI] synonym: "oligosacarido" RELATED [ChEBI] synonym: "oligosacaridos" RELATED [IUPAC] synonym: "Oligosaccharide" EXACT [KEGG_COMPOUND] synonym: "oligosaccharides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00930 is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:167559 ! glycan [Term] id: CHEBI:50733 name: nutraceutical namespace: chebi_ontology def: "A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance." [] subset: 3_STAR synonym: "Dietary Supplement" RELATED [ChEBI] synonym: "Food Supplementation" RELATED [ChEBI] synonym: "Nutritional supplement" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50750 name: EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor namespace: chebi_ontology alt_id: CHEBI:132229 alt_id: CHEBI:50234 def: "A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands." [] subset: 3_STAR synonym: "DNA gyrase inhibitor" RELATED [ChEBI] synonym: "DNA gyrase inhibitors" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitors" RELATED [ChEBI] synonym: "DNA topoisomerase II inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase II inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.3 inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.3 inhibitors" RELATED [ChEBI] synonym: "inhibitor of type II topoisomerase" RELATED [ChEBI] synonym: "inhibitors of type II topoisomerase" RELATED [ChEBI] synonym: "topoisomerase II inhibitor" RELATED [ChEBI] synonym: "topoisomerase II inhibitors" RELATED [ChEBI] synonym: "topoisomerase-II inhibitor" RELATED [ChEBI] synonym: "topoisomerase-II inhibitors" RELATED [ChEBI] synonym: "type II DNA topoisomerase inhibitor" RELATED [ChEBI] synonym: "type II DNA topoisomerase inhibitors" RELATED [ChEBI] is_a: CHEBI:70727 ! topoisomerase inhibitor [Term] id: CHEBI:50845 name: doxycycline namespace: chebi_ontology alt_id: CHEBI:42135 alt_id: CHEBI:4713 def: "Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis." [] subset: 3_STAR synonym: "(4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" RELATED [PDBeChem] synonym: "(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "5-hydroxy-alpha-6-deoxytetracycline" RELATED [ChemIDplus] synonym: "6alpha-deoxy-5-oxytetracycline" RELATED [ChemIDplus] synonym: "doxiciclina" RELATED INN [ChemIDplus] synonym: "Doxycyclin" RELATED [ChEBI] synonym: "Doxycycline" EXACT [KEGG_COMPOUND] synonym: "doxycycline" RELATED INN [KEGG_DRUG] synonym: "doxycycline (anhydrous)" RELATED [ChemIDplus] synonym: "doxycyclinum" RELATED INN [ChemIDplus] synonym: "Jenacyclin" RELATED BRAND_NAME [DrugBank] synonym: "Supracyclin" RELATED BRAND_NAME [DrugBank] synonym: "Vibramycin" RELATED BRAND_NAME [DrugBank] xref: Beilstein:3041790 {source="Beilstein"} xref: CAS:564-25-0 {source="KEGG COMPOUND"} xref: CAS:564-25-0 {source="ChemIDplus"} xref: Chemspider:10469369 xref: Drug_Central:961 {source="DrugCentral"} xref: DrugBank:DB00254 xref: HMDB:HMDB0014399 xref: KEGG:C06973 xref: KEGG:D07876 xref: KNApSAcK:C00017127 xref: LIPID_MAPS_instance:LMPK07000001 {source="LIPID MAPS"} xref: MetaCyc:CPD-19256 xref: Patent:US3019260 xref: Patent:US3200149 xref: PDBeChem:DXT xref: PMCID:PMC8464303 {source="Europe PMC"} xref: PMCID:PMC8466018 {source="Europe PMC"} xref: PMID:11477376 {source="Europe PMC"} xref: PMID:11850258 {source="Europe PMC"} xref: PMID:11891205 {source="Europe PMC"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:16651635 {source="Europe PMC"} xref: PMID:19630297 {source="Europe PMC"} xref: PMID:23698443 {source="Europe PMC"} xref: PMID:24134630 {source="Europe PMC"} xref: PMID:34128838 {source="Europe PMC"} xref: PMID:34228348 {source="Europe PMC"} xref: PMID:34318509 {source="Europe PMC"} xref: PMID:34338231 {source="Europe PMC"} xref: PMID:34355683 {source="Europe PMC"} xref: PMID:34551605 {source="Europe PMC"} xref: PMID:34577552 {source="Europe PMC"} xref: Reaxys:3041790 {source="Reaxys"} xref: VSDB:1840 xref: Wikipedia:Doxycycline is_a: CHEBI:26895 ! tetracyclines relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:38068 ! has role antimalarial relationship: RO:0000087 CHEBI:50846 ! has role immunomodulator relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H24N2O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JBIWCJUYHHGXTC-AKNGSSGZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "444.43464" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "444.15327" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12[C@@H](C)c3cccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]2O" xsd:string [Term] id: CHEBI:50846 name: immunomodulator namespace: chebi_ontology def: "Biologically active substance whose activity affects or plays a role in the functioning of the immune system." [] subset: 3_STAR synonym: "Biomodulator" RELATED [ChEBI] synonym: "Immune factor" RELATED [ChEBI] synonym: "Immunologic factor" RELATED [ChEBI] synonym: "Immunological factor" RELATED [ChEBI] synonym: "immunomodulators" RELATED [ChEBI] xref: Wikipedia:Immunotherapy is_a: CHEBI:23888 ! drug is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:50847 name: immunological adjuvant namespace: chebi_ontology def: "A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity." [] subset: 3_STAR synonym: "Immunoactivator" RELATED [ChEBI] synonym: "Immunoadjuvant" RELATED [ChEBI] synonym: "Immunologic adjuvant" RELATED [ChEBI] synonym: "Immunopotentiator" RELATED [ChEBI] synonym: "Immunostimulant" RELATED [ChEBI] xref: Wikipedia:Immunologic_adjuvant is_a: CHEBI:50846 ! immunomodulator is_a: CHEBI:60809 ! adjuvant [Term] id: CHEBI:50860 name: organic molecular entity namespace: chebi_ontology alt_id: CHEBI:25700 alt_id: CHEBI:33244 def: "Any molecular entity that contains carbon." [] subset: 3_STAR synonym: "organic compounds" RELATED [ChEBI] synonym: "organic entity" RELATED [ChEBI] synonym: "organic molecular entities" RELATED [ChEBI] is_a: CHEBI:33582 ! carbon group molecular entity relationship: has_part CHEBI:27594 ! carbon atom [Term] id: CHEBI:50893 name: azaarene namespace: chebi_ontology subset: 3_STAR synonym: "azaarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:50902 name: genotoxin namespace: chebi_ontology def: "A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells." [] subset: 3_STAR synonym: "genotoxic agent" RELATED [ChEBI] synonym: "genotoxic agents" RELATED [ChEBI] synonym: "genotoxins" RELATED [ChEBI] xref: Wikipedia:Genotoxicity is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50903 name: carcinogenic agent namespace: chebi_ontology def: "A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities." [] subset: 3_STAR synonym: "agente carcinogeno" RELATED [ChEBI] synonym: "cancerigene" RELATED [ChEBI] synonym: "cancerogene" RELATED [ChEBI] synonym: "carcinogen" RELATED [ChEBI] synonym: "carcinogene" RELATED [ChEBI] synonym: "carcinogenic agents" RELATED [ChEBI] synonym: "carcinogeno" RELATED [ChEBI] synonym: "carcinogens" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50904 name: allergen namespace: chebi_ontology def: "A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy." [] subset: 3_STAR synonym: "alergeno" RELATED [ChEBI] synonym: "allergene" RELATED [ChEBI] synonym: "allergenic agent" RELATED [ChEBI] xref: Wikipedia:Allergen is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50906 name: role namespace: chebi_ontology def: "A role is particular behaviour which a material entity may exhibit." [] subset: 3_STAR is_a: BFO:0000023 ! role [Term] id: CHEBI:50908 name: hepatotoxic agent namespace: chebi_ontology def: "A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals." [] subset: 3_STAR synonym: "agente hepatotoxico" RELATED [ChEBI] synonym: "hepatotoxic agents" RELATED [ChEBI] synonym: "hepatotoxicant" RELATED [ChEBI] synonym: "hepatotoxicants" RELATED [ChEBI] synonym: "hepatotoxin" RELATED [ChEBI] synonym: "hepatotoxins" RELATED [ChEBI] synonym: "hepatoxic agent" RELATED [ChEBI] synonym: "hepatoxicant" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50909 name: nephrotoxic agent namespace: chebi_ontology def: "A role played by a chemical compound exihibiting itself through the ability to induce damage to the kidney in animals." [] subset: 3_STAR synonym: "agente nefrotoxico" RELATED [ChEBI] synonym: "nephrotoxicant" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50910 name: neurotoxin namespace: chebi_ontology alt_id: CHEBI:50911 def: "A poison that interferes with the functions of the nervous system." [] subset: 3_STAR synonym: "agente neurotoxico" RELATED [ChEBI] synonym: "nerve poison" RELATED [ChEBI] synonym: "nerve poisons" RELATED [ChEBI] synonym: "neurotoxic agent" RELATED [ChEBI] synonym: "neurotoxic agents" RELATED [ChEBI] synonym: "neurotoxicant" RELATED [ChEBI] synonym: "neurotoxins" RELATED [ChEBI] xref: Wikipedia:Neurotoxin is_a: CHEBI:52209 ! aetiopathogenetic role is_a: CHEBI:64909 ! poison [Term] id: CHEBI:50994 name: primary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." [] subset: 3_STAR synonym: "primary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion [Term] id: CHEBI:50995 name: secondary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "secondary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:50996 name: tertiary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "tertiary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_base_of CHEBI:137982 ! tertiary ammonium ion [Term] id: CHEBI:5100 name: flucytosine namespace: chebi_ontology def: "An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections." [] subset: 3_STAR synonym: "4-amino-5-fluoropyrimidin-2(1H)-one" EXACT IUPAC_NAME [IUPAC] synonym: "5-FC" RELATED [KEGG_DRUG] synonym: "5-Fluorocystosine" RELATED [ChemIDplus] synonym: "5-Fluorocytosine" RELATED [ChemIDplus] synonym: "Ancobon (TN)" RELATED [KEGG_DRUG] synonym: "Ancotil" RELATED BRAND_NAME [ChemIDplus] synonym: "flucytosina" RELATED INN [WHO_MedNet] synonym: "flucytosine" RELATED INN [WHO_MedNet] synonym: "flucytosinum" RELATED INN [WHO_MedNet] xref: CAS:2022-85-7 {source="KEGG DRUG"} xref: CAS:2022-85-7 {source="ChemIDplus"} xref: Drug_Central:1188 {source="DrugCentral"} xref: DrugBank:DB01099 xref: HMDB:HMDB0015231 xref: KEGG:D00323 xref: LINCS:LSM-5878 xref: Patent:US2802005 xref: Patent:US2945038 xref: Patent:US3040026 xref: PDBeChem:1LD xref: PMID:11519290 {source="Europe PMC"} xref: PMID:14871609 {source="Europe PMC"} xref: PMID:18731030 {source="Europe PMC"} xref: PMID:23576540 {source="Europe PMC"} xref: PMID:25649231 {source="Europe PMC"} xref: PMID:26201447 {source="Europe PMC"} xref: PMID:28166217 {source="Europe PMC"} xref: Wikipedia:Flucytosine is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38337 ! pyrimidone is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:60783 ! nucleoside analogue is_a: CHEBI:87205 ! pyrimidine antifungal drug relationship: has_functional_parent CHEBI:16040 ! cytosine relationship: RO:0000087 CHEBI:50266 ! has role prodrug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H4FN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XRECTZIEBJDKEO-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "129.09250" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "129.03384" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1nc(=O)[nH]cc1F" xsd:string [Term] id: CHEBI:51026 name: macrocycle namespace: chebi_ontology def: "A cyclic compound containing nine or more atoms as part of the cyclic system." [] subset: 3_STAR synonym: "macrocycle" EXACT IUPAC_NAME [IUPAC] synonym: "macrocycles" RELATED [ChEBI] synonym: "Makrocyclen" RELATED [ChEBI] synonym: "makrocyclische Verbindungen" RELATED [ChEBI] synonym: "Makrozyklen" RELATED [ChEBI] synonym: "makrozyklische Verbindungen" RELATED [ChEBI] xref: Wikipedia:Macrocycle is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:51061 name: hormone receptor modulator namespace: chebi_ontology def: "A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." [] subset: 3_STAR synonym: "hormone receptor modulators" RELATED [ChEBI] is_a: CHEBI:90710 ! receptor modulator [Term] id: CHEBI:51086 name: chemical role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a chemical context." [] subset: 3_STAR is_a: BFO:0000023 ! role is_a: CHEBI:50906 ! role [Term] id: CHEBI:51121 name: fluorescent dye namespace: chebi_ontology subset: 3_STAR synonym: "fluorescent dyes" RELATED [ChEBI] is_a: CHEBI:37958 ! dye [Term] id: CHEBI:51143 name: nitrogen molecular entity namespace: chebi_ontology alt_id: CHEBI:25556 alt_id: CHEBI:7594 subset: 3_STAR synonym: "nitrogen compounds" RELATED [ChEBI] synonym: "nitrogen molecular entities" RELATED [ChEBI] synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND] xref: KEGG:C06061 is_a: CHEBI:33302 ! pnictogen molecular entity relationship: has_part CHEBI:25555 ! nitrogen atom [Term] id: CHEBI:51144 name: nitrogen group namespace: chebi_ontology subset: 3_STAR synonym: "nitrogen group" EXACT [ChEBI] synonym: "nitrogen groups" RELATED [ChEBI] synonym: "nitrogen-containing group" RELATED [ChEBI] synonym: "nitrogenous group" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:51151 name: dipolar compound namespace: chebi_ontology def: "An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." [] subset: 3_STAR synonym: "dipolar compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:51208 name: mecillinam namespace: chebi_ontology def: "A penicillin in which the 6beta substituent is [(azepan-1-yl)methylidene]amino; an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6beta-{[(azepan-1-yl)methylidene]amino}-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "amdinocillin" RELATED [ChemIDplus] synonym: "Coactin" RELATED BRAND_NAME [DrugBank] synonym: "mecilinamo" RELATED INN [ChemIDplus] synonym: "mecillinam" RELATED INN [ChemIDplus] synonym: "mecillinamum" RELATED INN [ChemIDplus] synonym: "penicillin HX" RELATED [ChemIDplus] xref: Beilstein:1223657 {source="Beilstein"} xref: CAS:32887-01-7 {source="ChemIDplus"} xref: DrugBank:DB01163 xref: LINCS:LSM-5528 xref: Patent:DE2055531 xref: Patent:US3957764 xref: Reaxys:1223657 {source="Reaxys"} is_a: CHEBI:17334 ! penicillin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H23N3O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H23N3O3S/c1-15(2)11(14(20)21)18-12(19)10(13(18)22-15)16-9-17-7-5-3-4-6-8-17/h9-11,13H,3-8H2,1-2H3,(H,20,21)/t10-,11+,13-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BWWVAEOLVKTZFQ-NTZNESFSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "325.42754" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.14601" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@]12[H])N1CCCCCC1" xsd:string [Term] id: CHEBI:51217 name: fluorochrome namespace: chebi_ontology def: "A fluorescent dye used to stain biological specimens." [] subset: 3_STAR synonym: "fluorochromes" RELATED [ChEBI] is_a: CHEBI:51121 ! fluorescent dye [Term] id: CHEBI:51256 name: amoxicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:6077298 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:2676 ! amoxicillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H18N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/p-1/t9-,10-,11+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSQZJLSUYDQPKJ-NJBDSQKTSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "364.39734" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "364.09727" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C([O-])=O" xsd:string [Term] id: CHEBI:51269 name: acenes namespace: chebi_ontology def: "Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound [Term] id: CHEBI:51270 name: tetracenes namespace: chebi_ontology def: "Compounds containing a tetracene skeleton." [] subset: 3_STAR synonym: "naphthacenes" RELATED [ChEBI] is_a: CHEBI:51269 ! acenes [Term] id: CHEBI:51276 name: thioureas namespace: chebi_ontology def: "Compounds of general formula RR'NC(=S)NR''R'''." [] subset: 3_STAR is_a: CHEBI:50492 ! thiocarbonyl compound [Term] id: CHEBI:51308 name: dinitrile namespace: chebi_ontology def: "A dinitrile is a compound containing two nitrile groups." [] subset: 3_STAR synonym: "dinitrile" EXACT [ChEBI] synonym: "dinitriles" RELATED [ChEBI] is_a: CHEBI:18379 ! nitrile [Term] id: CHEBI:51336 name: metal sulfate namespace: chebi_ontology def: "Sulfate salts where the cation is a metal ion." [] subset: 3_STAR synonym: "metal sulfates" RELATED [ChEBI] is_a: CHEBI:24840 ! inorganic sulfate salt [Term] id: CHEBI:51337 name: organic sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "organic sulfate salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:35175 ! sulfate salt [Term] id: CHEBI:51354 name: benzylpenicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "penicillin G" RELATED [UniProt] xref: Beilstein:3915298 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:18208 ! benzylpenicillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H17N2O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/p-1/t11-,12+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JGSARLDLIJGVTE-MBNYWOFBSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "333.38326" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "333.09145" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc1ccccc1)C([O-])=O" xsd:string [Term] id: CHEBI:51356 name: penicillinate anion namespace: chebi_ontology alt_id: CHEBI:58108 def: "Any anion formed by loss of a proton from the carboxy group of a penicillin." [] subset: 3_STAR synonym: "a penicillin" RELATED [UniProt] synonym: "penicillin anion" RELATED [ChEBI] synonym: "penicillin anions" RELATED [ChEBI] is_a: CHEBI:47811 ! penamcarboxylate relationship: is_conjugate_base_of CHEBI:17334 ! penicillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H10N2O4SR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "242.25200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "242.03613" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC([*])=O)C([O-])=O" xsd:string [Term] id: CHEBI:51373 name: GABA agonist namespace: chebi_ontology def: "A drug that binds to and activates gamma-aminobutyric acid receptors." [] subset: 3_STAR synonym: "GABA agonists" RELATED [ChEBI] synonym: "GABA receptor agonist" RELATED [ChEBI] synonym: "GABA receptor agonists" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor agonist" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor agonists" RELATED [ChEBI] is_a: CHEBI:51374 ! GABA agent [Term] id: CHEBI:51374 name: GABA agent namespace: chebi_ontology def: "A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems." [] subset: 3_STAR is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:51402 name: phenylenediamine namespace: chebi_ontology def: "A benzene substituted with two amino groups." [] subset: 3_STAR synonym: "benzenediamine" EXACT IUPAC_NAME [IUPAC] synonym: "diaminobenzene" RELATED [ChEBI] is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:35410 ! primary diamine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H8N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "108.141" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "108.06875" xsd:string [Term] id: CHEBI:51422 name: organodiyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." [] subset: 3_STAR synonym: "organodiyl groups" RELATED [ChEBI] is_a: CHEBI:51446 ! organic divalent group [Term] id: CHEBI:51446 name: organic divalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51447 name: organic univalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51454 name: cyclopropanes namespace: chebi_ontology def: "Cyclopropane and its derivatives formed by substitution." [] subset: 3_STAR is_a: CHEBI:33598 ! carbocyclic compound [Term] id: CHEBI:51683 name: methoxybenzenes namespace: chebi_ontology def: "Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups." [] subset: 3_STAR synonym: "methoxybenzene" RELATED [ChEBI] is_a: CHEBI:22712 ! benzenes is_a: CHEBI:35618 ! aromatic ether [Term] id: CHEBI:51689 name: enone namespace: chebi_ontology def: "An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position." [] subset: 3_STAR synonym: "enones" RELATED [ChEBI] xref: Wikipedia:Enone is_a: CHEBI:51721 ! alpha,beta-unsaturated ketone is_a: CHEBI:78840 ! olefinic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3OR4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "52.03150" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "51.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]\\C([*])=C(\\[*])C([*])=O" xsd:string [Term] id: CHEBI:51702 name: enoate ester namespace: chebi_ontology def: "An alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position." [] subset: 3_STAR synonym: "enoate" RELATED [ChEBI] synonym: "enoate esters" RELATED [ChEBI] synonym: "enoates" RELATED [ChEBI] is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester is_a: CHEBI:78840 ! olefinic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3O2R4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "68.03090" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "67.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]\\C([*])=C(\\[*])C(=O)O[*]" xsd:string [Term] id: CHEBI:51721 name: alpha,beta-unsaturated ketone namespace: chebi_ontology def: "A ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) or R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] subset: 3_STAR synonym: "alpha,beta-unsaturated ketones" RELATED [ChEBI] is_a: CHEBI:17087 ! ketone [Term] id: CHEBI:51737 name: alpha,beta-unsaturated carboxylic ester namespace: chebi_ontology def: "A carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) or R(1)C#C-C(=O)OR(2) (R(2) =/= H) in which the ester C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] subset: 3_STAR synonym: "alpha,beta-unsaturated carboxylic esters" RELATED [ChEBI] is_a: CHEBI:33308 ! carboxylic ester [Term] id: CHEBI:51750 name: alpha,beta-unsaturated carboxylic acid amide namespace: chebi_ontology def: "A monocarboxylic amide of general formula R(1)R(2)C=CR(3)-C(=O)NR(4)R(5) or R(1)C#C-C(=O)NR(2)R(3) in which the amide C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] subset: 3_STAR synonym: "alpha,beta-unsaturated amide" RELATED [ChEBI] synonym: "alpha,beta-unsaturated carboxamide" RELATED [ChEBI] synonym: "alpha,beta-unsaturated monocarboxylic acid amide" RELATED [ChEBI] synonym: "alpha,beta-unsaturated monocarboxylic acid amides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:51751 name: enamide namespace: chebi_ontology def: "An alpha,beta-unsaturated carboxylic acid amide of general formula R(1)R(2)C=CR(3)-C(=O)NR(4)R(5) in which the amide C=O function is conjugated to a C=C double bond at the alpha,beta position." [] subset: 3_STAR synonym: "enamides" RELATED [ChEBI] is_a: CHEBI:51750 ! alpha,beta-unsaturated carboxylic acid amide is_a: CHEBI:78840 ! olefinic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3NOR5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "66.03820" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "65.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]\\C([*])=C(\\[*])C(=O)N([*])[*]" xsd:string [Term] id: CHEBI:51811 name: ticarcillin(2-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-carboxylato-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "6beta-{[(2R)-2-carboxylato-2-thiophen-3-ylacetyl]amino}-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:5780670 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:9587 ! ticarcillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H14N2O6S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/p-2/t7-,8-,9+,12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OHKOGUYZJXTSFX-KZFFXBSXSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "382.41354" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "382.03043" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@]([H])(C([O-])=O)c1ccsc1)C([O-])=O" xsd:string [Term] id: CHEBI:51867 name: methyl ketone namespace: chebi_ontology def: "A ketone of formula RC(=O)CH3 (R =/= H)." [] subset: 3_STAR synonym: "methyl ketones" RELATED [ChEBI] is_a: CHEBI:17087 ! ketone [Term] id: CHEBI:51897 name: carbenicillin(2-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[carboxylato(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "6beta-(2-carboxylato-2-phenylacetamido)-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:5394984 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:3393 ! carbenicillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H16N2O6S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25)/p-2/t9?,10-,11+,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FPPNZSSZRUTDAP-UWFZAAFLSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "376.38482" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "376.07400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C(C([O-])=O)c1ccccc1)C([O-])=O" xsd:string [Term] id: CHEBI:5195 name: furazolidone namespace: chebi_ontology def: "A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera." [] subset: 3_STAR synonym: "3-(5'-Nitrofurfuralamino)-2-oxazolidone" RELATED [ChemIDplus] synonym: "3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone" RELATED [ChemIDplus] synonym: "3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone" RELATED [ChemIDplus] synonym: "3-[(5-Nitrofurylidene)amino]-2-oxazolidone" RELATED [ChemIDplus] synonym: "3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone" RELATED [ChemIDplus] synonym: "3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one" EXACT IUPAC_NAME [IUPAC] synonym: "5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine" RELATED [NIST_Chemistry_WebBook] synonym: "Furazolidona" RELATED INN [ChemIDplus] synonym: "Furazolidone" EXACT [KEGG_COMPOUND] synonym: "furazolidone" RELATED INN [WHO_MedNet] synonym: "Furazolidonum" RELATED INN [ChemIDplus] synonym: "Furoxone" RELATED [KEGG_DRUG] synonym: "FZL" RELATED [ChEBI] synonym: "N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone" RELATED [ChemIDplus] synonym: "N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one" RELATED [NIST_Chemistry_WebBook] synonym: "N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one" RELATED [ChemIDplus] synonym: "Nitrofurazolidone" RELATED [DrugBank] synonym: "Nitrofurazolidonum" RELATED [DrugBank] xref: Beilstein:384794 {source="Beilstein"} xref: CAS:67-45-8 {source="NIST Chemistry WebBook"} xref: CAS:67-45-8 {source="ChemIDplus"} xref: CAS:67-45-8 {source="KEGG DRUG"} xref: CAS:67-45-8 {source="KEGG COMPOUND"} xref: CAS:67-45-8 {source="DrugBank"} xref: Drug_Central:1257 {source="DrugCentral"} xref: DrugBank:DB00614 xref: HMDB:HMDB0014752 xref: KEGG:C07999 xref: KEGG:D00830 xref: LINCS:LSM-6543 xref: Patent:GB735136 xref: Patent:US2742462 xref: Patent:US2759931 xref: Patent:US2927110 xref: PMID:10735922 {source="Europe PMC"} xref: PMID:14500876 {source="Europe PMC"} xref: PMID:15666977 {source="Europe PMC"} xref: PMID:16225499 {source="Europe PMC"} xref: PMID:17422910 {source="Europe PMC"} xref: PMID:21817887 {source="Europe PMC"} xref: PMID:22024820 {source="Europe PMC"} xref: PMID:22177019 {source="Europe PMC"} xref: PMID:22221615 {source="Europe PMC"} xref: PMID:22226073 {source="Europe PMC"} xref: PMID:22228494 {source="Europe PMC"} xref: PMID:22240115 {source="Europe PMC"} xref: PMID:22249086 {source="Europe PMC"} xref: PMID:22260837 {source="Europe PMC"} xref: PMID:22362365 {source="Europe PMC"} xref: PMID:22759325 {source="Europe PMC"} xref: PMID:22829809 {source="Europe PMC"} xref: PMID:22868168 {source="Europe PMC"} xref: PMID:22877600 {source="Europe PMC"} xref: PMID:23112108 {source="Europe PMC"} xref: PMID:23151414 {source="Europe PMC"} xref: PMID:23153221 {source="Europe PMC"} xref: PMID:23261742 {source="Europe PMC"} xref: PMID:23279258 {source="Europe PMC"} xref: PMID:23285433 {source="Europe PMC"} xref: PMID:23376004 {source="Europe PMC"} xref: PMID:23403439 {source="Europe PMC"} xref: PMID:23418857 {source="Europe PMC"} xref: PMID:23429422 {source="Europe PMC"} xref: PMID:23461927 {source="Europe PMC"} xref: Reaxys:384794 {source="Reaxys"} xref: Wikipedia:Furazolidone is_a: CHEBI:38329 ! oxazolidines is_a: CHEBI:87230 ! nitrofuran antibiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:38623 ! has role EC 1.4.3.4 (monoamine oxidase) inhibitor relationship: RO:0000087 CHEBI:50685 ! has role antitrichomonal drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H7N3O5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PLHJDBGFXBMTGZ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "225.15830" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "225.03857" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-][N+](=O)c1ccc(C=NN2CCOC2=O)o1" xsd:string [Term] id: CHEBI:51958 name: organic polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:51959 name: organic tricyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic tricyclic compounds" RELATED [ChEBI] is_a: CHEBI:51958 ! organic polycyclic compound [Term] id: CHEBI:52017 name: dicloxacillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "6beta-{[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carboxamido}-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:4773354 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:4511 ! dicloxacillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H16Cl2N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/p-1/t13-,14+,17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YFAGHNZHGGCZAX-JKIFEVAISA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "469.31800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "468.01932" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1c(Cl)cccc1Cl)C([O-])=O" xsd:string [Term] id: CHEBI:52064 name: methicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "6beta-(2,6-dimethoxybenzamido)-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "6beta-(2,6-dimethoxybenzamido)penicillanate" RELATED [ChEBI] xref: Beilstein:4770226 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:6827 ! methicillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H19N2O6S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H20N2O6S/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23)/p-1/t11-,12+,15-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RJQXTJLFIWVMTO-TYNCELHUSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "379.40800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "379.09693" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(OC)cccc1OC)C([O-])=O" xsd:string [Term] id: CHEBI:52090 name: methoxide namespace: chebi_ontology def: "An organic anion that is the conjugate base of methanol." [] subset: 3_STAR synonym: "methoxide ion" RELATED [ChEBI] xref: Reaxys:1839368 {source="Reaxys"} is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:17790 ! methanol relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3O/c1-2/h1H3/q-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBTOZLQBSIZIKS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "31.03390" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.01894" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[O-]" xsd:string [Term] id: CHEBI:52132 name: oxacillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "2,2-dimethyl-6beta-(5-methyl-3-phenyl-1,2-oxazole-4-carboxamido)penam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanate" RELATED [ChEBI] xref: Beilstein:4278284 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:7809 ! oxacillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H18N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H19N3O5S/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26)/p-1/t13-,14+,17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UWYHMGVUTGAWSP-JKIFEVAISA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "400.42800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "400.09727" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1ccccc1)C([O-])=O" xsd:string [Term] id: CHEBI:52206 name: biochemical role namespace: chebi_ontology def: "A biological role played by the molecular entity or part thereof within a biochemical context." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52208 name: biophysical role namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52209 name: aetiopathogenetic role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." [] subset: 3_STAR synonym: "etiopathogenetic agent" RELATED [ChEBI] synonym: "etiopathogenetic role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52210 name: pharmacological role namespace: chebi_ontology def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52211 name: physiological role namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52214 name: ligand namespace: chebi_ontology def: "Any molecule or ion capable of binding to a central metal atom to form coordination complexes." [] subset: 3_STAR synonym: "ligands" RELATED [ChEBI] xref: Wikipedia:Ligand is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:52217 name: pharmaceutical namespace: chebi_ontology alt_id: CHEBI:33293 alt_id: CHEBI:33294 def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." [] subset: 3_STAR synonym: "farmaco" RELATED [ChEBI] synonym: "medicament" RELATED [ChEBI] synonym: "pharmaceuticals" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:52362 name: ortho-fused heteroarene namespace: chebi_ontology def: "An ortho-fused compound in which at least one of the rings contains at least one heteroatom." [] subset: 3_STAR synonym: "ortho-fused heteroarenes" RELATED [ChEBI] is_a: CHEBI:33637 ! ortho-fused compound is_a: CHEBI:38180 ! polycyclic heteroarene [Term] id: CHEBI:52395 name: oxyketone namespace: chebi_ontology def: "A compound with the general formula R2C=O (R=/=H) where one or more of the R groups contains an oxy (-O-) group." [] subset: 3_STAR synonym: "oxyketones" RELATED [ChEBI] is_a: CHEBI:17087 ! ketone [Term] id: CHEBI:52396 name: alpha-oxyketone namespace: chebi_ontology def: "An oxyketone with the general formula R2C(=O) (R=/=H) where one or more of the R groups contains an oxy (-O-) group and the oxy and carbonyl groups are bonded to the same carbon atom." [] subset: 3_STAR synonym: "alpha-oxyketones" RELATED [ChEBI] is_a: CHEBI:52395 ! oxyketone [Term] id: CHEBI:52433 name: piperacillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "6beta-{(2R)-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:5369991 {source="Beilstein"} is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:8232 ! piperacillin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H26N5O7S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27N5O7S/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34)/p-1/t13-,14-,15+,20-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IVBHGBMCVLDMKU-GXNBUGAJSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "516.54700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "516.15584" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)N1CCN(CC)C(=O)C1=O)c1ccccc1)C([O-])=O" xsd:string [Term] id: CHEBI:52440 name: cephalosporin carboxylic acid anion namespace: chebi_ontology subset: 3_STAR synonym: "cephalosporin carboxylate" RELATED [ChEBI] synonym: "cephalosporin carboxylates" RELATED [ChEBI] synonym: "cephalosporin carboxylic acid anions" RELATED [ChEBI] synonym: "cephalosporincarboxylate" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:52492 name: mancozeb namespace: chebi_ontology def: "A mixture composed from maneb and zineb, which is used as a broad-spectrum contact fungicide." [] subset: 3_STAR synonym: "Dithane" RELATED BRAND_NAME [ChemIDplus] synonym: "ethylenebis(dithiocarbamic acid) manganese zinc complex" RELATED [ChemIDplus] synonym: "Karamate" RELATED BRAND_NAME [ChemIDplus] synonym: "Mancofol" RELATED BRAND_NAME [ChemIDplus] synonym: "Mancomix" RELATED BRAND_NAME [ChemIDplus] synonym: "Mancozeb" EXACT [KEGG_COMPOUND] synonym: "Manzate" RELATED BRAND_NAME [ChemIDplus] synonym: "Manzeb" RELATED BRAND_NAME [ChemIDplus] synonym: "Manzin" RELATED BRAND_NAME [ChemIDplus] synonym: "Novozir" RELATED BRAND_NAME [ChemIDplus] synonym: "Othane" RELATED BRAND_NAME [ChemIDplus] synonym: "Penncozeb" RELATED BRAND_NAME [ChemIDplus] xref: Beilstein:8188972 {source="Beilstein"} xref: CAS:8018-01-7 {source="ChemIDplus"} xref: CAS:8018-01-7 {source="KEGG COMPOUND"} xref: KEGG:C15225 xref: Pesticides:mancozeb {source="Alan Wood's Pesticides"} xref: PMID:22369882 {source="Europe PMC"} xref: PMID:23024109 {source="Europe PMC"} xref: PMID:23103283 {source="Europe PMC"} xref: PMID:23242257 {source="Europe PMC"} xref: PMID:23436297 {source="Europe PMC"} xref: PMID:23542819 {source="Europe PMC"} xref: PMID:24041529 {source="Europe PMC"} xref: PMID:24360436 {source="Europe PMC"} xref: PMID:24499300 {source="Europe PMC"} xref: PMID:24518345 {source="Europe PMC"} xref: PMID:24530807 {source="Europe PMC"} xref: PMID:24764117 {source="Europe PMC"} xref: Reaxys:13196351 {source="Reaxys"} xref: Reaxys:8188972 {source="Reaxys"} xref: Wikipedia:Mancozeb is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:52497 ! maneb relationship: has_part CHEBI:52498 ! zineb relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:52497 name: maneb namespace: chebi_ontology def: "A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab." [] subset: 3_STAR synonym: "[{2-[(sulfanylcarbothioyl)amino]ethyl}carbamodithioato(2-)-kappa(2)S,S']manganese" EXACT IUPAC_NAME [IUPAC] synonym: "manganese ethane-1,2-diyldicarbamodithioate" RELATED [IUPAC] xref: Beilstein:3747585 {source="Beilstein"} xref: CAS:12427-38-2 {source="ChemIDplus"} xref: CAS:12427-38-2 {source="KEGG COMPOUND"} xref: KEGG:C15231 xref: Pesticides:maneb {source="Alan Wood's Pesticides"} xref: PMID:18605226 {source="Europe PMC"} xref: PMID:20188092 {source="Europe PMC"} xref: PMID:20430411 {source="Europe PMC"} xref: PMID:21314462 {source="Europe PMC"} xref: PMID:21402726 {source="Europe PMC"} xref: PMID:23764462 {source="Europe PMC"} xref: PMID:24936438 {source="Europe PMC"} xref: PMID:25275677 {source="Europe PMC"} xref: PPDB:426 xref: Reaxys:3747585 {source="Reaxys"} xref: Wikipedia:Maneb is_a: CHEBI:60027 ! polymer relationship: has_part CHEBI:35117 ! manganese coordination entity relationship: has_part CHEBI:83060 ! dithiocarbamate salt relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(C4H6MnN2S4)n" xsd:string [Term] id: CHEBI:52498 name: zineb namespace: chebi_ontology def: "A polymeric complex of zinc with the ethylene bis(dithiocarbamate) anionic ligand. Formerly used as an agricultural fungicide for the control of downy mildews and rusts, its use is no longer permitted in the US or the EU." [] subset: 3_STAR synonym: "[{2-[(sulfanylcarbothioyl)amino]ethyl}carbamodithioato(2-)-kappa(2)S,S']zinc" EXACT IUPAC_NAME [IUPAC] synonym: "zinc ethane-1,2-diyldicarbamodithioate" RELATED [IUPAC] xref: Beilstein:4165797 {source="Beilstein"} xref: CAS:12122-67-7 {source="KEGG COMPOUND"} xref: CAS:12122-67-7 {source="ChemIDplus"} xref: KEGG:C15232 xref: Patent:CN1648120 xref: Patent:US2690448 xref: Pesticides:zineb {source="Alan Wood's Pesticides"} xref: PMID:22155123 {source="Europe PMC"} xref: PMID:23871785 {source="Europe PMC"} xref: PMID:465777 {source="Europe PMC"} xref: PPDB:683 xref: Reaxys:4165797 {source="Reaxys"} xref: Wikipedia:Zineb is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:36566 ! zinc coordination entity is_a: CHEBI:83060 ! dithiocarbamate salt relationship: has_part CHEBI:77308 ! ethylenebis(dithiocarbamate) relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H6N2S4Zn" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H8N2S4.Zn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AMHNZOICSMBGDH-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "275.77300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.87052" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Zn++].[S-]C(=S)NCCNC([S-])=S" xsd:string [Term] id: CHEBI:52549 name: sordarin namespace: chebi_ontology def: "An antifungal metabolite of Sordaria araneosa that inhibits protein synthesis. It has a tetracyclic diterpene glycoside structure." [] subset: 3_STAR synonym: "(1R,3aR,4S,4aR,7R,7aR,8aS)-8a-{[(6-deoxy-4-O-methyl-beta-D-altropyranosyl)oxy]methyl}-4-formyl-7-methyl-3-(propan-2-yl)-4,4a,5,6,7,7a,8,8a-octahydro-1,4-methano-s-indacene-3a(1H)-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Antibiotic SL-2266" RELATED [ChemIDplus] synonym: "sordarin B" RELATED [SUBMITTER] xref: CAS:11076-17-8 {source="ChemIDplus"} xref: CAS:11076-17-8 {source="SUBMITTER"} is_a: CHEBI:24400 ! glycoside is_a: CHEBI:52557 ! tetracyclic diterpenoid is_a: CHEBI:63367 ! monosaccharide derivative relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H40O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H40O8/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32)/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OGGVRVMISBQNMQ-YPBSLCSMSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "492.603" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "492.27232" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@]12([C@]3([C@](C[C@@]1([C@]4([H])CC[C@H]([C@]4(C3)[H])C)C=O)(C=C2C(C)C)[H])CO[C@]5([C@H]([C@@H]([C@@H]([C@H](O5)C)OC)O)O)[H])C(O)=O" xsd:string [Term] id: CHEBI:52557 name: tetracyclic diterpenoid namespace: chebi_ontology def: "A diterpenoid with a tetracyclic skeleton." [] subset: 3_STAR synonym: "tetracyclic diterpenoids" RELATED [ChEBI] is_a: CHEBI:23849 ! diterpenoid [Term] id: CHEBI:52646 name: leptomycin B namespace: chebi_ontology def: "A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17." [] subset: 3_STAR synonym: "(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "antibiotic ATS 1287B" RELATED [ChEBI] synonym: "Antibiotic CI 940" RELATED [ChemIDplus] synonym: "Antibiotic CL 1957A" RELATED [ChemIDplus] synonym: "Antibiotic PD 114720" RELATED [ChEBI] synonym: "ATS 1287B" RELATED [ChEBI] synonym: "LMB" RELATED [ChEBI] xref: Beilstein:7958583 {source="Beilstein"} xref: Beilstein:8299374 {source="Beilstein"} xref: CAS:87081-35-4 {source="ChemIDplus"} xref: PMID:10421839 {source="Europe PMC"} xref: PMID:10430904 {source="Europe PMC"} xref: PMID:11134317 {source="Europe PMC"} xref: PMID:12468543 {source="Europe PMC"} xref: PMID:16964287 {source="Europe PMC"} xref: PMID:6874586 {source="Europe PMC"} xref: PMID:9683540 {source="Europe PMC"} xref: Reaxys:8299374 {source="Reaxys"} is_a: CHEBI:140345 ! hydroxy polyunsaturated fatty acid is_a: CHEBI:52651 ! leptomycin relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H48O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YACHGFWEQXFSBS-XYERBDPFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "540.73060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "540.34509" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC\\C(\\C=C\\[C@@H]1OC(=O)C=C[C@@H]1C)=C\\[C@H](C)C\\C=C\\C(\\C)=C\\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\\C(C)=C\\C(O)=O" xsd:string [Term] id: CHEBI:52651 name: leptomycin namespace: chebi_ontology def: "A complex, very long chain, polyunsaturated fatty acid whose core structure comprises 8-oxononadeca-2,10,12,16,18-pentaenoic acid having methyl substituents at positions 3, 5, 7, 9, 11 and 15 and a 3,6-dihydropyran-6-one-2-yl group at position 19." [] subset: 3_STAR synonym: "leptomycins" RELATED [ChEBI] xref: CAS:88026-21-5 {source="ChemIDplus"} xref: PMID:6874586 {source="Europe PMC"} is_a: CHEBI:24654 ! hydroxy fatty acid is_a: CHEBI:25000 ! lactone is_a: CHEBI:26208 ! polyunsaturated fatty acid is_a: CHEBI:27283 ! very long-chain fatty acid is_a: CHEBI:35819 ! branched-chain fatty acid is_a: CHEBI:59644 ! oxo fatty acid is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid relationship: has_functional_parent CHEBI:28866 ! tetracosanoic acid [Term] id: CHEBI:52726 name: proteasome inhibitor namespace: chebi_ontology def: "A drug that blocks the action of proteasomes, cellular complexes that break down proteins." [] subset: 3_STAR synonym: "proteasome inhibitors" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:5280 name: gatifloxacin namespace: chebi_ontology alt_id: CHEBI:101712 def: "A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes." [] subset: 3_STAR synonym: "1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "AM 1155" RELATED [KEGG_COMPOUND] synonym: "gatifloxacin" RELATED INN [KEGG_DRUG] synonym: "gatifloxacine" RELATED INN [WHO_MedNet] synonym: "gatifloxacino" RELATED INN [WHO_MedNet] synonym: "gatifloxacinum" RELATED INN [WHO_MedNet] xref: Beilstein:7445861 {source="Beilstein"} xref: CAS:112811-59-3 {source="DrugBank"} xref: CAS:112811-59-3 {source="KEGG COMPOUND"} xref: CAS:112811-59-3 {source="ChemIDplus"} xref: Drug_Central:1280 {source="DrugCentral"} xref: DrugBank:DB01044 xref: Gmelin:2281206 {source="Gmelin"} xref: KEGG:C07661 xref: KEGG:D08011 xref: LINCS:LSM-5139 xref: Patent:EP230295 xref: Patent:US4980470 xref: PMID:10737746 {source="ChEMBL"} xref: PMID:12190308 {source="ChEMBL"} xref: PMID:12620077 {source="ChEMBL"} xref: PMID:12873512 {source="ChEMBL"} xref: PMID:12904069 {source="ChEMBL"} xref: PMID:15125930 {source="ChEMBL"} xref: PMID:15745831 {source="ChEMBL"} xref: PMID:15911273 {source="ChEMBL"} xref: PMID:16078842 {source="ChEMBL"} xref: PMID:16337791 {source="ChEMBL"} xref: PMID:16554151 {source="ChEMBL"} xref: PMID:16759086 {source="ChEMBL"} xref: PMID:17043111 {source="ChEMBL"} xref: PMID:17043131 {source="ChEMBL"} xref: PMID:17064062 {source="ChEMBL"} xref: PMID:17116666 {source="ChEMBL"} xref: PMID:17116668 {source="ChEMBL"} xref: PMID:17157008 {source="ChEMBL"} xref: PMID:17220425 {source="ChEMBL"} xref: PMID:17261623 {source="ChEMBL"} xref: PMID:17276057 {source="ChEMBL"} xref: PMID:17296740 {source="ChEMBL"} xref: PMID:17325221 {source="ChEMBL"} xref: PMID:17387152 {source="ChEMBL"} xref: PMID:17804222 {source="ChEMBL"} xref: PMID:17933535 {source="ChEMBL"} xref: PMID:17960928 {source="ChEMBL"} xref: PMID:18078756 {source="ChEMBL"} xref: PMID:18304818 {source="ChEMBL"} xref: PMID:26963935 {source="Europe PMC"} xref: PMID:7473575 {source="ChEMBL"} xref: Reaxys:7445861 {source="Reaxys"} xref: Wikipedia:Gatifloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:86324 ! quinolone antibiotic relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H22FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUBOMFCQGDBHNK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "375.39410" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "375.15943" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1" xsd:string [Term] id: CHEBI:52898 name: azamacrocycle namespace: chebi_ontology def: "A cyclic macromolecule containing one or more nitrogen atoms in place of carbon either as the divalent group NH for the group CH2 or a single trivalent nitrogen atom for the group CH." [] subset: 3_STAR synonym: "aza macrocycle" RELATED [SUBMITTER] synonym: "aza macrocyclic compound" RELATED [SUBMITTER] synonym: "aza-macrocycle" RELATED [SUBMITTER] synonym: "azamacrocycles" RELATED [ChEBI] is_a: CHEBI:51026 ! macrocycle [Term] id: CHEBI:53000 name: epitope namespace: chebi_ontology def: "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." [] subset: 3_STAR synonym: "antigenic determinant" RELATED [ChEBI] synonym: "epitope function" RELATED [ChEBI] synonym: "epitope role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:53559 name: topoisomerase IV inhibitor namespace: chebi_ontology def: "A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands." [] subset: 3_STAR synonym: "topoisomerase IV inhibitors" RELATED [ChEBI] is_a: CHEBI:70727 ! topoisomerase inhibitor [Term] id: CHEBI:53628 name: 2,6-dideoxy-alpha-D-glucoside namespace: chebi_ontology def: "An alpha-D-glucoside deoxygenated at C-2 and C-6." [] subset: 3_STAR is_a: CHEBI:22390 ! alpha-D-glucoside [Term] id: CHEBI:53634 name: neomycin C namespace: chebi_ontology def: "A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine C." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] xref: CAS:66-86-4 {source="ChemIDplus"} xref: CAS:66-86-4 {source="KEGG COMPOUND"} xref: KEGG:C15652 xref: PMID:13355298 {source="Europe PMC"} xref: PMID:17206729 {source="Europe PMC"} xref: PMID:19382560 {source="Europe PMC"} xref: PMID:19713992 {source="Europe PMC"} xref: PMID:4907002 {source="Europe PMC"} xref: PMID:5137586 {source="Europe PMC"} xref: PMID:804015 {source="Europe PMC"} xref: PMID:849920 {source="Europe PMC"} xref: PMID:9682160 {source="Europe PMC"} xref: Reaxys:101620 {source="Reaxys"} is_a: CHEBI:47779 ! aminoglycoside relationship: is_conjugate_base_of CHEBI:65077 ! neomycin C(6+) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H46N6O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PGBHMTALBVVCIT-VZXHOKRSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "614.64370" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "614.31229" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:53655 name: cefoxitin(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion having methoxy, 2-thienylacetamido and carbamoyloxymethyl side-groups, formed by proton loss from the carboxy group of the semisynthetic cephamycin antibiotic cefoxitin." [] subset: 3_STAR synonym: "(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "3-[(carbamoyloxy)methyl]-7alpha-methoxy-7beta-[(2-thienylacetyl)amino]-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:4045290 {source="Beilstein"} xref: Reaxys:4045290 {source="Reaxys"} is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:209807 ! cefoxitin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H16N3O7S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/p-1/t14-,16+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WZOZEZRFJCJXNZ-ZBFHGGJFSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "426.44400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "426.04352" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)Cc1cccs1)OC)C([O-])=O" xsd:string [Term] id: CHEBI:53657 name: cefazolin(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups, formed by proton loss from the carboxy group of cefazolin." [] subset: 3_STAR synonym: "(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:4241223 {source="Beilstein"} is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:474053 ! cefazolin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H13N8O4S3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/p-1/t9-,12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MLYYVTUWGNIJIB-BXKDBHETSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "453.49900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "453.02274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(CSc3nnc(C)s3)=C(N1C(=O)[C@H]2NC(=O)Cn1cnnn1)C([O-])=O" xsd:string [Term] id: CHEBI:53658 name: ceftriaxone(1-) namespace: chebi_ontology def: "A cephalosporin carboxylis acid anion having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups, formed by proton loss from the carboxy group of ceftriaxone." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:7066100 {source="Beilstein"} xref: MetaCyc:CPD-12294 xref: Reaxys:7066100 {source="Reaxys"} is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:29007 ! ceftriaxone property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H17N8O7S3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/p-1/b24-8-/t9-,15-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VAAUVRVFOQPIGI-SPQHTLEESA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "553.57200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "553.03878" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(CSc3nc(=O)c(=O)[nH]n3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C([O-])=O" xsd:string [Term] id: CHEBI:53661 name: alexidine namespace: chebi_ontology def: "An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge." [] subset: 3_STAR synonym: "1,1'-Hexamethylenebis(5-(2-ethylhexyl)biguanide)" RELATED [ChemIDplus] synonym: "alexidina" RELATED INN [ChemIDplus] synonym: "alexidine" RELATED INN [ChemIDplus] synonym: "alexidinum" RELATED INN [ChemIDplus] synonym: "bisguadine" RELATED [ChEBI] synonym: "N,N''''-hexane-1,6-diylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)]" EXACT IUPAC_NAME [IUPAC] synonym: "N,N'-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide" RELATED [ChemIDplus] xref: Beilstein:2404807 {source="Beilstein"} xref: CAS:22573-93-9 {source="ChemIDplus"} xref: Drug_Central:113 {source="DrugCentral"} xref: LINCS:LSM-4432 xref: Patent:CN101624356 xref: PMID:10848923 {source="Europe PMC"} xref: PMID:22152633 {source="Europe PMC"} xref: PMID:22495680 {source="Europe PMC"} xref: PMID:23492900 {source="Europe PMC"} xref: PMID:23970139 {source="Europe PMC"} xref: PMID:24139264 {source="Europe PMC"} xref: PMID:265389 {source="Europe PMC"} xref: PMID:381628 {source="Europe PMC"} xref: Reaxys:2404807 {source="Reaxys"} xref: Wikipedia:Alexidine is_a: CHEBI:53662 ! biguanides relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H56N10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H56N10/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LFVVNPBBFUSSHL-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "508.78980" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "508.46894" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC" xsd:string [Term] id: CHEBI:53662 name: biguanides namespace: chebi_ontology alt_id: CHEBI:35529 def: "A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton." [] subset: 3_STAR is_a: CHEBI:24436 ! guanidines relationship: RO:0000087 CHEBI:35526 ! has role hypoglycemic agent [Term] id: CHEBI:53665 name: oxazinoquinoline namespace: chebi_ontology def: "Any organic heterotricyclic compound based on a skeleton comprised of an oxazine ring fused onto a quinoline system." [] subset: 3_STAR synonym: "oxazinoquinolines" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound [Term] id: CHEBI:53670 name: cefotaxime(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups, formed by proton loss from the carboxy group of the cephalosporin cefotaxime." [] subset: 3_STAR synonym: "(6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "3-(acetoxymethyl)-7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:8174207 {source="Beilstein"} xref: Gmelin:1794119 {source="Gmelin"} xref: Reaxys:8174207 {source="Reaxys"} is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:204928 ! cefotaxime property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H16N5O7S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/p-1/b20-9-/t10-,14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GPRBEKHLDVQUJE-QSWIMTSFSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "454.45800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "454.04966" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C([O-])=O" xsd:string [Term] id: CHEBI:53676 name: ceftazidime(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion formed by proton loss from the carboxy group of ceftazidime, a cephalosporin having 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino and 3-pyridinium-1-ylmethyl side-groups." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxylatopropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxylatopropan-2-yl)oxy]imino}acetyl]amino}-3-(pyridinium-1-ylmethyl)-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:6630563 {source="Beilstein"} xref: Gmelin:1795652 {source="Gmelin"} xref: Reaxys:6630563 {source="Reaxys"} is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:3508 ! ceftazidime property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H21N6O7S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/p-1/b26-13-/t14-,18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ORFOPKXBNMVMKC-DWVKKRMSSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "545.56800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "545.09186" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(C[n+]3ccccc3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C([O-])=O)\\c1csc(N)n1)C([O-])=O" xsd:string [Term] id: CHEBI:5385 name: gliotoxin namespace: chebi_ontology def: "A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi." [] subset: 3_STAR synonym: "(3R,5aS,6S,10aR)-6-hydroxy-3-(hydroxymethyl)-2-methyl-2,3,6,10-tetrahydro-5aH-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione" EXACT IUPAC_NAME [IUPAC] synonym: "Aspergillin" RELATED [ChemIDplus] xref: Beilstein:50675 {source="ChemIDplus"} xref: CAS:67-99-2 {source="ChemIDplus"} xref: CAS:67-99-2 {source="KEGG COMPOUND"} xref: KEGG:C10595 xref: KNApSAcK:C00002340 xref: PMID:16020669 {source="Europe PMC"} xref: PMID:23832115 {source="Europe PMC"} xref: PMID:24368570 {source="Europe PMC"} xref: PMID:24847038 {source="Europe PMC"} xref: PMID:25062268 {source="Europe PMC"} xref: PMID:25494483 {source="Europe PMC"} xref: PMID:25766143 {source="Europe PMC"} xref: PMID:25816130 {source="Europe PMC"} xref: PMID:25982450 {source="Europe PMC"} xref: PPDB:2793 xref: Reaxys:50675 {source="Reaxys"} xref: Wikipedia:Gliotoxin is_a: CHEBI:35489 ! organic disulfide is_a: CHEBI:38163 ! organic heterotetracyclic compound is_a: CHEBI:46761 ! dipeptide is_a: CHEBI:64130 ! pyrazinoindole relationship: RO:0000087 CHEBI:25442 ! has role mycotoxin relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:52726 ! has role proteasome inhibitor relationship: RO:0000087 CHEBI:64133 ! has role EC 2.5.1.58 (protein farnesyltransferase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H14N2O4S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FIVPIPIDMRVLAY-RBJBARPLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "326.39100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "326.03950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12[C@@H](O)C=CC=C1C[C@@]13SS[C@@](CO)(N(C)C1=O)C(=O)N23" xsd:string [Term] id: CHEBI:5435 name: piperidine-2,6-dione namespace: chebi_ontology def: "A dicarboximide that is piperidine which is substituted by oxo groups at positions 2 and 6." [] subset: 3_STAR synonym: "2,6-Diketopiperidine" RELATED [KEGG_COMPOUND] synonym: "2,6-piperidinedione" RELATED [ChemIDplus] synonym: "Glutarimide" RELATED [KEGG_COMPOUND] synonym: "Piperidine-2,6-dione" EXACT [KEGG_COMPOUND] synonym: "piperidine-2,6-dione" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:110052 {source="Beilstein"} xref: CAS:1121-89-7 {source="NIST Chemistry WebBook"} xref: CAS:1121-89-7 {source="ChemIDplus"} xref: CAS:1121-89-7 {source="KEGG COMPOUND"} xref: Gmelin:971891 {source="Gmelin"} xref: KEGG:C07275 xref: PMID:10783491 {source="Europe PMC"} xref: Reaxys:110052 {source="Reaxys"} is_a: CHEBI:35356 ! dicarboximide is_a: CHEBI:48589 ! piperidones property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H7NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H7NO2/c7-4-2-1-3-5(8)6-4/h1-3H2,(H,6,7,8)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KNCYXPMJDCCGSJ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "113.11460" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "113.04768" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1CCCC(=O)N1" xsd:string [Term] id: CHEBI:5530 name: gramicidin S namespace: chebi_ontology subset: 3_STAR synonym: "1,10-anhydro(L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithine)" EXACT IUPAC_NAME [IUPAC] synonym: "Cyclo(L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl)" RELATED [ChemIDplus] synonym: "gramicidin" RELATED [ChEBI] synonym: "Gramicidin C" RELATED [ChemIDplus] synonym: "Gramicidin S" EXACT [KEGG_COMPOUND] synonym: "Gramicin S 1" RELATED [ChemIDplus] synonym: "Gramicin S-A" RELATED [ChEBI] xref: CAS:113-73-5 {source="ChemIDplus"} xref: CAS:113-73-5 {source="KEGG COMPOUND"} xref: KEGG:C11218 is_a: CHEBI:24613 ! homodetic cyclic peptide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C60H92N12O10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C60H92N12O10/c1-35(2)31-43-53(75)67-45(33-39-19-11-9-12-20-39)59(81)71-29-17-25-47(71)55(77)70-50(38(7)8)58(80)64-42(24-16-28-62)52(74)66-44(32-36(3)4)54(76)68-46(34-40-21-13-10-14-22-40)60(82)72-30-18-26-48(72)56(78)69-49(37(5)6)57(79)63-41(23-15-27-61)51(73)65-43/h9-14,19-22,35-38,41-50H,15-18,23-34,61-62H2,1-8H3,(H,63,79)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,76)(H,69,78)(H,70,77)/t41-,42-,43-,44-,45+,46+,47-,48-,49-,50-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IUAYMJGZBVDSGL-XNNAEKOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1141.44736" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1140.70594" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@]1([H])CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC2=O)C(C)C)C(C)C" xsd:string [Term] id: CHEBI:55346 name: anidulafungin namespace: chebi_ontology def: "A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis." [] subset: 3_STAR synonym: "anidulafungin" RELATED INN [ChemIDplus] synonym: "anidulafungina" RELATED INN [WHO_MedNet] synonym: "anidulafungine" RELATED INN [WHO_MedNet] synonym: "anidulafunginum" RELATED INN [WHO_MedNet] synonym: "Eraxis" RELATED BRAND_NAME [KEGG_DRUG] synonym: "N-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-4''-(pentyloxy)-1,1':4',1''-terphenyl-4-carboxamide" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:7408417 {source="Beilstein"} xref: CAS:166663-25-8 {source="KEGG DRUG"} xref: CAS:166663-25-8 {source="ChemIDplus"} xref: CAS:166663-25-8 {source="DrugBank"} xref: DrugBank:DB00362 xref: KEGG:D03211 xref: PMID:15482216 {source="Europe PMC"} xref: PMID:16770294 {source="Europe PMC"} xref: PMID:17316149 {source="Europe PMC"} xref: PMID:19072176 {source="Europe PMC"} xref: PMID:19113794 {source="Europe PMC"} xref: PMID:19877739 {source="Europe PMC"} xref: PMID:19877740 {source="Europe PMC"} xref: PMID:19877741 {source="Europe PMC"} xref: PMID:19877742 {source="Europe PMC"} xref: PMID:24165173 {source="Europe PMC"} xref: PMID:24955796 {source="Europe PMC"} xref: PMID:25473029 {source="Europe PMC"} xref: Reaxys:7408417 {source="Reaxys"} xref: Wikipedia:Anidulafungin is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:52898 ! azamacrocycle is_a: CHEBI:57248 ! echinocandin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:87113 ! antibiotic antifungal drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C58H73N7O17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JHVAMHSQVVQIOT-MFAJLEFUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1140.23690" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1139.50629" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCOc1ccc(cc1)-c1ccc(cc1)-c1ccc(cc1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@@H](C)O" xsd:string [Term] id: CHEBI:55370 name: imidazolidinone namespace: chebi_ontology def: "An imidazolidine containing one or more oxo groups." [] subset: 3_STAR synonym: "imidazolidinones" RELATED [ChEBI] is_a: CHEBI:38261 ! imidazolidines [Term] id: CHEBI:55373 name: isoxazoles namespace: chebi_ontology alt_id: CHEBI:46813 def: "Oxazoles in which the N and O atoms are adjacent." [] subset: 3_STAR synonym: "1,2-oxazoles" RELATED [ChEBI] synonym: "isoxazoles" EXACT [ChEBI] is_a: CHEBI:35790 ! oxazole [Term] id: CHEBI:55374 name: oxazolidinone namespace: chebi_ontology def: "An oxazolidine containing one or more oxo groups." [] subset: 3_STAR synonym: "oxazolidinedione" RELATED [ChEBI] synonym: "oxazolidinediones" RELATED [ChEBI] synonym: "oxazolidinones" RELATED [ChEBI] is_a: CHEBI:38329 ! oxazolidines [Term] id: CHEBI:55429 name: cephamycin namespace: chebi_ontology def: "Any member of the cephamycin sub-group of cephem antibiotics, differing from cephalosporins in possessing a methoxy group at the 7alpha-position of the cephem nucleus, and in being resistant to beta-lactamase." [] subset: 3_STAR synonym: "cephamycins" RELATED [ChEBI] xref: PMID:1107228 {source="Europe PMC"} is_a: CHEBI:38311 ! cephem property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H7NO4SR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "213.212" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "213.00958" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N12C([C@](*)(C1=O)OC)SCC(=C2C(O)=O)*" xsd:string [Term] id: CHEBI:55517 name: trichothecene namespace: chebi_ontology def: "Any one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain." [] subset: 3_STAR synonym: "trichothecenes" RELATED [ChEBI] is_a: CHEBI:26658 ! sesquiterpenoid is_a: CHEBI:32955 ! epoxide is_a: CHEBI:38166 ! organic heteropolycyclic compound relationship: RO:0000087 CHEBI:25442 ! has role mycotoxin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17O2R5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "229.29430" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "229.12285" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12O[C@]3([H])[C@H]([*])[C@@H]([*])[C@@](C)(C33CO3)C1(C[*])C([*])C([*])C(C)=C2" xsd:string [Term] id: CHEBI:5653 name: hemiacetal namespace: chebi_ontology def: "A compound having the general formula RR'C(OH)OR'' (R'' =/= H)." [] subset: 3_STAR synonym: "Hemiacetal" EXACT [KEGG_COMPOUND] synonym: "hemiacetals" EXACT IUPAC_NAME [IUPAC] synonym: "hemiacetals" RELATED [ChEBI] is_a: CHEBI:30879 ! alcohol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "46.025" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "46.00548" xsd:string [Term] id: CHEBI:5686 name: heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of at least two different elements." [] subset: 3_STAR synonym: "compuesto heterociclico" RELATED [IUPAC] synonym: "compuestos heterociclicos" RELATED [IUPAC] synonym: "heterocycle" RELATED [ChEBI] synonym: "Heterocyclic compound" EXACT [KEGG_COMPOUND] synonym: "heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:57248 name: echinocandin namespace: chebi_ontology def: "Any one of a family of large lipopeptides that are inhibitors of the enzyme 1,3-beta-glucan synthase, thus damaging fungal cell walls. Echinocandins are fungicidal against most Candida spp and fungistatic against Aspergillus spp." [] subset: 3_STAR synonym: "echinocandins" RELATED [ChEBI] is_a: CHEBI:46895 ! lipopeptide is_a: CHEBI:86478 ! antibiotic antifungal agent [Term] id: CHEBI:57726 name: D-proline zwitterion namespace: chebi_ontology def: "A D-alpha-amino acid zwitterion that is D-proline in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." [] subset: 3_STAR synonym: "(2R)-pyrrolidinium-2-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "D-proline" RELATED [UniProt] xref: MetaCyc:D-PROLINE is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion relationship: is_tautomer_of CHEBI:16313 ! D-proline property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-SCSAIBSYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "115.13050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "115.06333" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[C@H]1CCC[NH2+]1" xsd:string [Term] id: CHEBI:57869 name: 6-aminopenicillanic acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of 6-aminopenicillanic acid arising from migration of a proton from the carboxy group to the 6-amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-azaniumyl-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [ChEBI] synonym: "6-aminopenicillanate" RELATED [UniProt] synonym: "6-azaniumyl-2,2-dimethylpenam-3alpha-carboxylate" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_conjugate_acid_of CHEBI:30938 ! 6-aminopenicillanate relationship: is_tautomer_of CHEBI:16705 ! 6-aminopenicillanic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H12N2O3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H12N2O3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,9H2,1-2H3,(H,12,13)/t3-,4+,6-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NGHVIOIJCVXTGV-ALEPSDHESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "216.25700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "216.05686" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2[NH3+])C([O-])=O" xsd:string [Term] id: CHEBI:57971 name: hygromycin B(3+) namespace: chebi_ontology def: "An ammonium ion that is the trication of hygromycin B arising from protonation of the three amino groups; major species at pH 7.3." [] subset: 3_STAR synonym: "(1R,2S,3R,5S,6R)-3-azaniumyl-2,6-dihydroxy-5-(methylazaniumyl)cyclohexyl O-6-azaniumyl-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-beta-D-talopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "hygromycin B" RELATED [UniProt] synonym: "hygromycin B trication" RELATED [ChEBI] is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:16976 ! hygromycin B property_value: http://purl.obolibrary.org/obo/chebi/charge "+3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H40N3O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/p+3/t5-,6?,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GRRNUXAQVGOGFE-NZSRVPFOSA-Q" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "530.54390" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "530.25447" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H]1C[C@@H]([NH3+])[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3O[C@@]4(O[C@H](C([NH3+])CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O" xsd:string [Term] id: CHEBI:58007 name: streptomycin(3+) namespace: chebi_ontology def: "Trication of streptomycin arising from protonation of the guanidino and secondary amino groups." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,5R,6S)-2,4-bis{[amino(iminio)methyl]amino}-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-[2-deoxy-2-(methylammonio)-alpha-L-glucopyranosyl]-3-C-formyl-alpha-L-lyxofuranoside" EXACT IUPAC_NAME [IUPAC] synonym: "streptomycin" RELATED [UniProt] synonym: "streptomycin trication" RELATED [ChEBI] is_a: CHEBI:60251 ! guanidinium ion relationship: is_conjugate_acid_of CHEBI:17076 ! streptomycin property_value: http://purl.obolibrary.org/obo/chebi/charge "+3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H42N7O12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/p+3/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCSJYZPVAKXKNQ-HZYVHMACSA-Q" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "584.59790" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "584.28750" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@@H](O[C@@H](C)[C@]1(O)C=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](NC(N)=[NH2+])[C@@H](O)[C@@H]1NC(N)=[NH2+]" xsd:string [Term] id: CHEBI:58165 name: 3',5'-cyclic AMP(1-) namespace: chebi_ontology def: "An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3." [] subset: 3_STAR synonym: "3',5'-cyclic AMP" RELATED [UniProt] synonym: "3',5'-cyclic AMP anion" RELATED [ChEBI] synonym: "adenosine 3',5'-cyclic monophosphate" RELATED [ChEBI] synonym: "adenosine 3',5'-cyclic monophosphate anion" RELATED [ChEBI] synonym: "adenosine 3',5'-cyclic monophosphate(1-)" RELATED [ChEBI] synonym: "adenosine 3',5'-phosphate" EXACT IUPAC_NAME [IUPAC] xref: PMID:7870041 {source="Europe PMC"} xref: PMID:7870042 {source="Europe PMC"} xref: Reaxys:3720459 {source="Reaxys"} is_a: CHEBI:58945 ! organophosphate oxoanion relationship: is_conjugate_base_of CHEBI:17489 ! 3',5'-cyclic AMP relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H11N5O6P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IVOMOUWHDPKRLL-KQYNXXCUSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "328.19800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "328.04524" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O" xsd:string [Term] id: CHEBI:582124 name: myriocin namespace: chebi_ontology def: "An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity." [] subset: 3_STAR synonym: "(2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid" RELATED [ChEBI] synonym: "(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid" RELATED [ChEBI] synonym: "(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "antibiotic ISP-1" RELATED [ChEBI] synonym: "antibiotic ISP-I" RELATED [ChEBI] synonym: "ISP-1" RELATED [KEGG_COMPOUND] synonym: "ISP-I" RELATED [ChEBI] synonym: "thermozymocidin" RELATED [ChemIDplus] xref: AGR:IND607305181 {source="Europe PMC"} xref: Beilstein:5113331 {source="Beilstein"} xref: CAS:35891-70-4 {source="ChemIDplus"} xref: KEGG:C19914 xref: KNApSAcK:C00016936 xref: LIPID_MAPS_instance:LMFA01060203 {source="LIPID MAPS"} xref: PDBeChem:VRP xref: PMID:15679316 {source="ChEMBL"} xref: PMID:21456524 {source="Europe PMC"} xref: PMID:23178537 {source="Europe PMC"} xref: PMID:23659342 {source="Europe PMC"} xref: PMID:23802886 {source="Europe PMC"} xref: PMID:23957439 {source="Europe PMC"} xref: PMID:24141140 {source="Europe PMC"} xref: PMID:24395529 {source="Europe PMC"} xref: PMID:24456332 {source="Europe PMC"} xref: PMID:27621809 {source="Europe PMC"} xref: PMID:28621883 {source="Europe PMC"} xref: PMID:30123648 {source="Europe PMC"} xref: PMID:30883241 {source="Europe PMC"} xref: PMID:31447688 {source="Europe PMC"} xref: PMID:31639005 {source="Europe PMC"} xref: PMID:31701696 {source="Europe PMC"} xref: PMID:32091078 {source="Europe PMC"} xref: PMID:32212314 {source="Europe PMC"} xref: PMID:32435178 {source="Europe PMC"} xref: PMID:32954686 {source="Europe PMC"} xref: PMID:33378044 {source="Europe PMC"} xref: PMID:33441497 {source="Europe PMC"} xref: PMID:33482299 {source="Europe PMC"} xref: PMID:33558761 {source="Europe PMC"} xref: PMID:33731109 {source="Europe PMC"} xref: PMID:34324668 {source="Europe PMC"} xref: PMID:4694226 {source="Europe PMC"} xref: PMID:5076310 {source="Europe PMC"} xref: PMID:8020136 {source="Europe PMC"} xref: Reaxys:5113331 {source="Reaxys"} xref: Wikipedia:Myriocin is_a: CHEBI:35785 ! sphingoid is_a: CHEBI:35868 ! hydroxy monocarboxylic acid is_a: CHEBI:59755 ! alpha-amino fatty acid relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:59647 ! has role EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H39NO6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZZIKIHCNFWXKDY-GNTQXERDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "401.544" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "401.27774" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCC(=O)CCCCCC\\C=C\\C[C@@H](O)[C@H](O)[C@@](N)(CO)C(O)=O" xsd:string [Term] id: CHEBI:58214 name: kanamycin A(4+) namespace: chebi_ontology def: "A quadruply-charged organic cation arising from protonation of the four amino groups of kanamycin A; major species at pH 7.3." [] subset: 3_STAR synonym: "(1S,2R,3R,4S,6R)-4,6-diazaniumyl-3-(6-azaniumyl-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-azaniumyl-3-deoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "kanamycin A" RELATED [UniProt] synonym: "kanamycin A tetracation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:17630 ! kanamycin A relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H40N4O11" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/p+4/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SBUJHOSQTJFQJX-NOAMYHISSA-R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "488.53040" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "488.26716" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C[C@H]1O[C@H](O[C@@H]2[C@@H]([NH3+])C[C@@H]([NH3+])[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H]([NH3+])[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:5827 name: hymexazol namespace: chebi_ontology def: "A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces, Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals." [] subset: 3_STAR synonym: "3-Hydroxy-5-methylisoxazole" RELATED [ChemIDplus] synonym: "5-methyl-1,2-oxazol-3(2H)-one" EXACT IUPAC_NAME [IUPAC] synonym: "5-Methyl-3(2H)-isoxazolone" RELATED [ChemIDplus] synonym: "5-Methyl-3-hydroxyisoxazole" RELATED [ChemIDplus] synonym: "5-Methylisoxazol-3-ol" RELATED [ChemIDplus] synonym: "F 319" RELATED [ChemIDplus] synonym: "F-319" RELATED [ChemIDplus] synonym: "Hydroxyisoxazole" RELATED [ChemIDplus] synonym: "Hymexazole" RELATED [ChemIDplus] synonym: "NSC 217971" RELATED [ChemIDplus] synonym: "SF-6505" RELATED [ChemIDplus] xref: CAS:10004-44-1 {source="KEGG COMPOUND"} xref: CAS:10004-44-1 {source="ChemIDplus"} xref: KEGG:C11103 xref: Pesticides:hymexazol {source="Alan Wood's Pesticides"} xref: PMID:21959994 {source="Europe PMC"} xref: PMID:22307860 {source="Europe PMC"} xref: PPDB:388 xref: Reaxys:606046 {source="Reaxys"} is_a: CHEBI:55373 ! isoxazoles is_a: CHEBI:74818 ! heteroaryl hydroxy compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H5NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H5NO2/c1-3-2-4(6)5-7-3/h2H,1H3,(H,5,6)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KGVPNLBXJKTABS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "99.08800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "99.03203" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cc(O)no1" xsd:string [Term] id: CHEBI:58464 name: nucleoside 3',5'-cyclic phosphate anion namespace: chebi_ontology def: "The conjugate base of a nucleoside 3',5'-cyclic phosphate." [] subset: 3_STAR synonym: "a nucleoside 3',5'-cyclic phosphate" RELATED [UniProt] synonym: "nucleoside 3',5'-cyclic phosphate anions" RELATED [ChEBI] is_a: CHEBI:58945 ! organophosphate oxoanion relationship: is_conjugate_base_of CHEBI:18375 ! nucleoside 3',5'-cyclic phosphate property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H6O5PR2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "177.07190" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "176.99528" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]P1(=O)OC[C@H]2O[C@@H]([*])[C@H]([*])[C@@H]2O1" xsd:string [Term] id: CHEBI:58549 name: kanamycin B(5+) namespace: chebi_ontology def: "An organic cation that is the pentacation of kanamycin B, obtained by protonation of the primary amino groups." [] subset: 3_STAR synonym: "(1R,2S,3S,4R,6S)-4,6-diammmonio-3-(3-ammonio-3-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 2,6-diammmonio-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "kanamycin B" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:28098 ! kanamycin B property_value: http://purl.obolibrary.org/obo/chebi/charge "+5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H42N5O10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2/p+5/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SKKLOUVUUNMCJE-FQSMHNGLSA-S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "488.55360" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "488.29042" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C[C@H]1O[C@H](O[C@@H]2[C@@H]([NH3+])C[C@@H]([NH3+])[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H]([NH3+])[C@H]3O)[C@H]2O)[C@H]([NH3+])[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:58945 name: organophosphate oxoanion namespace: chebi_ontology def: "An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated." [] subset: 3_STAR synonym: "organophosphate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:26079 ! phosphoric acid derivative [Term] id: CHEBI:58950 name: very long-chain fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion with a chain length greater than C22." [] subset: 3_STAR synonym: "a very long-chain fatty acid" RELATED [UniProt] synonym: "very long-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:27283 ! very long-chain fatty acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string [Term] id: CHEBI:58951 name: short-chain fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)." [] subset: 3_STAR synonym: "a short-chain fatty acid" RELATED [UniProt] synonym: "short-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:26666 ! short-chain fatty acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string [Term] id: CHEBI:58953 name: saturated fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion in which there is no C-C unsaturation." [] subset: 3_STAR synonym: "saturated fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion [Term] id: CHEBI:58954 name: straight-chain saturated fatty acid anion namespace: chebi_ontology def: "Any saturated fatty acid anion lacking a carbon side-chain." [] subset: 3_STAR synonym: "straight-chain saturated fatty acid anions" RELATED [ChEBI] is_a: CHEBI:58953 ! saturated fatty acid anion relationship: is_conjugate_base_of CHEBI:39418 ! straight-chain saturated fatty acid [Term] id: CHEBI:58955 name: branched-chain fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion with a carbon side-chain or isopropyl termination." [] subset: 3_STAR synonym: "branched-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:35819 ! branched-chain fatty acid [Term] id: CHEBI:58958 name: organosulfate oxoanion namespace: chebi_ontology def: "An organic anion of general formula RS(=O)2O(-) where R is an organyl group." [] subset: 3_STAR synonym: "organosulfate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:33482 ! sulfur oxoanion relationship: has_functional_parent CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S(=O)(=O)O[*]" xsd:string [Term] id: CHEBI:59062 name: polymyxin namespace: chebi_ontology def: "Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria." [] subset: 3_STAR synonym: "polymixin" RELATED [ChEBI] synonym: "polymycin" RELATED [ChEBI] synonym: "polymyxins" RELATED [ChEBI] is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:46895 ! lipopeptide relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:59064 name: colistin A namespace: chebi_ontology def: "A polymyxin having a (6R)-6-methyloctanoyl group at the amino terminus." [] subset: 3_STAR synonym: "4,10-anhydro{N-[(6R)-6-methyloctanoyl]-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-leucyl-L-leucyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-threonine}" EXACT IUPAC_NAME [IUPAC] synonym: "Colistin A" EXACT [ChemIDplus] synonym: "Colistin IV" RELATED [ChemIDplus] synonym: "Polymixin E1" RELATED [ChemIDplus] synonym: "Polymyxin E1" RELATED [ChemIDplus] xref: Beilstein:8609559 {source="Beilstein"} xref: CAS:7722-44-3 {source="ChemIDplus"} xref: PMID:13058849 {source="Europe PMC"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:16931410 {source="Europe PMC"} xref: PMID:18625681 {source="Europe PMC"} xref: PMID:25249467 {source="Europe PMC"} xref: PMID:25609230 {source="Europe PMC"} xref: PMID:25832483 {source="Europe PMC"} xref: Reaxys:8609559 {source="Reaxys"} is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:59062 ! polymyxin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H100N16O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H100N16O13/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77)/t30-,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XDJYMJULXQKGMM-RVYUQJQSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1169.46050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1168.76558" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O" xsd:string [Term] id: CHEBI:59066 name: oxolinate namespace: chebi_ontology def: "Conjugate base of oxolinic acid." [] subset: 3_STAR synonym: "5-ethyl-8-oxo-5,8-dihydro-2H-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "5-ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylate" RELATED [IUPAC] xref: Beilstein:3563086 {source="Beilstein"} xref: PMID:776048 {source="Europe PMC"} is_a: CHEBI:38773 ! quinolinemonocarboxylate relationship: is_conjugate_base_of CHEBI:138856 ! oxolinic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H10NO5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KYGZCKSPAKDVKC-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "260.22220" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "260.05645" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCn1cc(C([O-])=O)c(=O)c2cc3OCOc3cc12" xsd:string [Term] id: CHEBI:59107 name: EC 3.4.24.* (metalloendopeptidase) inhibitor namespace: chebi_ontology alt_id: CHEBI:76786 def: "Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a metalloendopeptidase (EC 3.4.24.*)." [] subset: 3_STAR synonym: "EC 3.4.24.* (metalloendopeptidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.* inhibitor" RELATED [ChEBI] synonym: "EC 3.4.24.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of metalloendopeptidases" RELATED [ChEBI] synonym: "inhibitor of metalloendopeptidases (EC 3.4.24.*)" RELATED [ChEBI] synonym: "inhibitors of metalloendopeptidases" RELATED [ChEBI] synonym: "inhibitors of metalloendopeptidases (EC 3.4.24.*)" RELATED [ChEBI] synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitor" RELATED [ChEBI] synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitors" RELATED [ChEBI] synonym: "metalloendopeptidase inhibitors" RELATED [ChEBI] is_a: CHEBI:37670 ! protease inhibitor [Term] id: CHEBI:59163 name: biomarker namespace: chebi_ontology def: "A substance used as an indicator of a biological state." [] subset: 3_STAR synonym: "biological marker" RELATED [ChEBI] is_a: CHEBI:47867 ! indicator [Term] id: CHEBI:59202 name: straight-chain fatty acid namespace: chebi_ontology def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." [] subset: 3_STAR synonym: "straight-chain fatty acids" RELATED [ChEBI] is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:59203 ! straight-chain fatty acid anion [Term] id: CHEBI:59203 name: straight-chain fatty acid anion namespace: chebi_ontology def: "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." [] subset: 3_STAR synonym: "straight-chain FA anion" RELATED [ChEBI] synonym: "straight-chain FA anions" RELATED [ChEBI] synonym: "straight-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:59202 ! straight-chain fatty acid [Term] id: CHEBI:59285 name: EC 1.14.13.132 (squalene monooxygenase) inhibitor namespace: chebi_ontology def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132)." [] subset: 3_STAR synonym: "EC 1.14.13.132 (squalene monooxygenase) inhibitors" RELATED [ChEBI] synonym: "squalene 2,3-oxidocyclase inhibitor" RELATED [ChEBI] synonym: "squalene 2,3-oxidocyclase inhibitors" RELATED [ChEBI] synonym: "squalene epoxidase inhibitor" RELATED [ChEBI] synonym: "squalene epoxidase inhibitors" RELATED [ChEBI] synonym: "squalene hydroxylase inhibitor" RELATED [ChEBI] synonym: "squalene hydroxylase inhibitors" RELATED [ChEBI] synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitor" RELATED [ChEBI] synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitors" RELATED [ChEBI] synonym: "squalene monooxygenase inhibitor" RELATED [ChEBI] synonym: "squalene monooxygenase inhibitors" RELATED [ChEBI] synonym: "squalene oxydocyclase inhibitor" RELATED [ChEBI] synonym: "squalene oxydocyclase inhibitors" RELATED [ChEBI] synonym: "squalene-2,3-epoxidase inhibitor" RELATED [ChEBI] synonym: "squalene-2,3-epoxidase inhibitors" RELATED [ChEBI] synonym: "squalene-2,3-epoxide cyclase inhibitor" RELATED [ChEBI] synonym: "squalene-2,3-epoxide cyclase inhibitors" RELATED [ChEBI] is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor [Term] id: CHEBI:59349 name: cefepime(1+) namespace: chebi_ontology def: "The conjugate acid of cefepime." [] subset: 3_STAR synonym: "1-{[(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidinium" EXACT IUPAC_NAME [IUPAC] synonym: "7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidinium-1-yl)methyl]-3,4-didehydrocepham-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "cefepime conjugate acid" RELATED [ChEBI] xref: Beilstein:5196242 {source="Beilstein"} is_a: CHEBI:23066 ! cephalosporin relationship: is_conjugate_acid_of CHEBI:478164 ! cefepime property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H25N6O5S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/p+1/b23-12-/t13-,17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HVFLCNVBZFFHBT-ZKDACBOMSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "481.56900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "481.13224" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(C[N+]3(C)CCCC3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O" xsd:string [Term] id: CHEBI:59358 name: cefotetan(2-) namespace: chebi_ontology def: "The dianion formed by removal of a proton from each of the carboxylic acid groups of cefotetan." [] subset: 3_STAR synonym: "(6R,7S)-7-({[4-(2-amino-1-carboxylato-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "7beta-({[4-(2-amino-1-carboxylato-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino)-7alpha-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "cefotetan dianion" RELATED [ChEBI] xref: Beilstein:5701969 {source="Beilstein"} is_a: CHEBI:28965 ! dicarboxylic acid dianion relationship: is_conjugate_base_of CHEBI:3499 ! cefotetan property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H15N7O8S4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/p-2/b12-6-/t13?,15-,17+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SRZNHPXWXCNNDU-IXOPCIAXSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "573.60300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "572.98759" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@]2(NC(=O)C1SC(S1)=C(C(N)=O)C([O-])=O)OC)C([O-])=O" xsd:string [Term] id: CHEBI:59392 name: cephalexin(1-) namespace: chebi_ontology def: "The anion resulting from the removal of a proton from the carboxylic acid group of cephalexin." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "7beta-[(2R)-2-amino-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "cefalexin anion" RELATED [ChEBI] synonym: "cefalexin(1-)" RELATED [ChEBI] synonym: "cephalexin anion" RELATED [ChEBI] xref: Beilstein:8358366 {source="Beilstein"} is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:3534 ! cephalexin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H16N3O4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/p-1/t10-,11-,15-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZAIPMKNFIOOWCQ-UEKVPHQBSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "346.38100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "346.08670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C([O-])=O" xsd:string [Term] id: CHEBI:59517 name: DNA synthesis inhibitor namespace: chebi_ontology def: "Any substance that inhibits the synthesis of DNA." [] subset: 3_STAR synonym: "DNA synthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:59635 name: organophosphonate oxoanion namespace: chebi_ontology def: "An organic phosphonic acid derivative in which one or more oxygen atoms of the phosphonate group(s) has been deprotonated." [] subset: 3_STAR synonym: "organophosphonate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives [Term] id: CHEBI:59644 name: oxo fatty acid namespace: chebi_ontology def: "Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group." [] subset: 3_STAR synonym: "oxo fatty acids" RELATED [ChEBI] xref: PMID:6434570 {source="Europe PMC"} xref: PMID:8454196 {source="Europe PMC"} xref: PMID:8638935 {source="Europe PMC"} is_a: CHEBI:25754 ! oxo carboxylic acid is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:59836 ! oxo fatty acid anion [Term] id: CHEBI:59647 name: EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of serine palmitoyltransferase (EC 2.3.1.50)." [] subset: 3_STAR synonym: "3-oxosphinganine synthetase inhibitor" RELATED [ChEBI] synonym: "3-oxosphinganine synthetase inhibitors" RELATED [ChEBI] synonym: "acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitor" RELATED [ChEBI] synonym: "acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.50 inhibitor" RELATED [ChEBI] synonym: "EC 2.3.1.50 inhibitors" RELATED [ChEBI] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitor" RELATED [ChEBI] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitors" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase (EC 2.3.1.50) inhibitor" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase (EC 2.3.1.50) inhibitors" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase inhibitor" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase inhibitors" RELATED [ChEBI] synonym: "serine palmitoyltransferase inhibitor" RELATED [ChEBI] synonym: "serine palmitoyltransferase inhibitors" RELATED [ChEBI] synonym: "SPT inhibitor" RELATED [ChEBI] synonym: "SPT inhibitors" RELATED [ChEBI] xref: Wikipedia:Serine_C-palmitoyltransferase is_a: CHEBI:76878 ! EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor [Term] id: CHEBI:59650 name: amino fatty acid namespace: chebi_ontology def: "A fatty acid containing at least one amino substituent." [] subset: 3_STAR synonym: "amino FA" RELATED [ChEBI] synonym: "amino fatty acids" RELATED [ChEBI] synonym: "carboxylated base" RELATED [ChEBI] synonym: "carboxylated bases" RELATED [ChEBI] synonym: "lipoamino acid" RELATED [ChEBI] synonym: "lipoamino acids" RELATED [ChEBI] is_a: CHEBI:32952 ! amine is_a: CHEBI:33709 ! amino acid is_a: CHEBI:60690 ! nitrogen-containing fatty acid relationship: is_conjugate_acid_of CHEBI:61007 ! amino fatty acid anion [Term] id: CHEBI:59668 name: nikkomycin namespace: chebi_ontology def: "A class of nucleoside-peptide antibiotics which inhibit fungal chitin biosynthesis by inhibiting chitin synthase. Generally consist of a heterocyclic moiety (usually a nucleobase), an amino hexuronic acid and an amino acid containing a pyridine ring." [] subset: 3_STAR synonym: "nikkomycins" RELATED [ChEBI] is_a: CHEBI:36988 ! 5'-deoxyribonucleoside relationship: RO:0000087 CHEBI:25605 ! has role nucleoside antibiotic relationship: RO:0000087 CHEBI:59672 ! has role EC 2.4.1.16 (chitin synthase) inhibitor [Term] id: CHEBI:59672 name: EC 2.4.1.16 (chitin synthase) inhibitor namespace: chebi_ontology def: "A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of chitin synthase (EC 2.4.1.16)." [] subset: 3_STAR synonym: "chitin synthase (EC 2.4.1.16) inhibitor" RELATED [ChEBI] synonym: "chitin synthase (EC 2.4.1.16) inhibitors" RELATED [ChEBI] synonym: "chitin synthase inhibitor" RELATED [ChEBI] synonym: "chitin synthase inhibitors" RELATED [ChEBI] synonym: "chitin synthesis inhibitor" RELATED [ChEBI] synonym: "chitin synthesis inhibitors" RELATED [ChEBI] synonym: "chitin synthetase inhibitor" RELATED [ChEBI] synonym: "chitin synthetase inhibitors" RELATED [ChEBI] synonym: "chitin-UDP acetyl-glucosaminyl transferase inhibitor" RELATED [ChEBI] synonym: "chitin-UDP acetyl-glucosaminyl transferase inhibitors" RELATED [ChEBI] synonym: "chitin-UDP N-acetylglucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "chitin-UDP N-acetylglucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.16 (chitin synthase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.16 inhibitor" RELATED [ChEBI] synonym: "EC 2.4.1.16 inhibitors" RELATED [ChEBI] synonym: "trans-N-acetylglucosaminosylase inhibitor" RELATED [ChEBI] synonym: "trans-N-acetylglucosaminosylase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Chitin_synthase is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor [Term] id: CHEBI:59673 name: colistin B namespace: chebi_ontology def: "A polymyxin having a 6-methylheptanoyl group at the amino terminus." [] subset: 3_STAR synonym: "4,10-anhydro[N-(6-methylheptanoyl)-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-leucyl-L-leucyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-threonine]" EXACT IUPAC_NAME [IUPAC] synonym: "polymyxin E2" RELATED [ChEBI] xref: Beilstein:8185577 {source="Beilstein"} xref: CAS:7239-48-7 {source="ChemIDplus"} xref: PMID:16931410 {source="Europe PMC"} xref: PMID:18625681 {source="Europe PMC"} is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:59062 ! polymyxin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C52H98N16O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C52H98N16O13/c1-27(2)11-9-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-28(3)4)66-50(79)39(26-29(5)6)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KNIWPHSUTGNZST-SSWRVQTPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1155.43390" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1154.74993" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O" xsd:string [Term] id: CHEBI:59676 name: nystatins namespace: chebi_ontology def: "A class of polyene antifungal antibiotics produced by Streptomyces noursei, and other Streptomyces species." [] subset: 3_STAR xref: Patent:US2832719 xref: Patent:US3517100 xref: PMID:12230565 {source="Europe PMC"} xref: PMID:15504830 {source="Europe PMC"} xref: PMID:1793301 {source="Europe PMC"} is_a: CHEBI:22507 ! aminoglycoside antibiotic is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:26191 ! polyol is_a: CHEBI:36244 ! dicarboxylic acid monoester is_a: CHEBI:48121 ! polyene is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:59698 name: phosphoric acids namespace: chebi_ontology def: "Compounds containing one or more phosphoric acid units." [] subset: 3_STAR is_a: CHEBI:33457 ! phosphorus oxoacid [Term] id: CHEBI:59740 name: nucleophilic reagent namespace: chebi_ontology def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." [] subset: 3_STAR synonym: "nucleophile" RELATED [ChEBI] synonym: "nucleophiles" RELATED [ChEBI] synonym: "nucleophilic reagents" RELATED [ChEBI] is_a: CHEBI:33893 ! reagent is_a: CHEBI:39144 ! Lewis base [Term] id: CHEBI:59755 name: alpha-amino fatty acid namespace: chebi_ontology def: "A fatty acid with an amino substituent at position C-2." [] subset: 3_STAR synonym: "a-amino fatty acid" RELATED [ChEBI] synonym: "a-amino fatty acids" RELATED [ChEBI] synonym: "alpha-amino FA" RELATED [ChEBI] synonym: "alpha-amino fatty acids" RELATED [ChEBI] xref: PMID:3279209 {source="Europe PMC"} is_a: CHEBI:59650 ! amino fatty acid is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid [Term] id: CHEBI:59769 name: acetal namespace: chebi_ontology def: "An organooxygen compound having the structure RR'C(OR'')(OR''') (R'', R''' =/= H). Mixed acetals have R'' and R''' groups which differ." [] subset: 3_STAR synonym: "acetals" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:59770 name: cyclic acetal namespace: chebi_ontology def: "An acetal in the molecule of which the acetal carbon and one or both oxygen atoms thereon are members of a ring." [] subset: 3_STAR synonym: "cyclic acetals" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:59769 ! acetal [Term] id: CHEBI:59772 name: hemiketal namespace: chebi_ontology def: "A hemiacetal having the structure RR(1)C(OH)OR(2) (R, R(1), R(2) =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group." [] subset: 3_STAR synonym: "hemiketals" RELATED [ChEBI] is_a: CHEBI:5653 ! hemiacetal property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2R3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "45.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(*)(O)(O*)*" xsd:string [Term] id: CHEBI:59777 name: ketal namespace: chebi_ontology def: "An acetal of formula R2C(OR)2 (R =/= H) derived from a ketone by replacement of the oxo group by two hydrocarbyloxy groups. The class name 'ketals', once abandoned by IUPAC, has been reinstated as a subclass of acetals." [] subset: 3_STAR synonym: "ketals" RELATED [ChEBI] is_a: CHEBI:59769 ! acetal [Term] id: CHEBI:59779 name: cyclic ketal namespace: chebi_ontology def: "A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring." [] subset: 3_STAR synonym: "cyclic ketals" RELATED [ChEBI] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:59777 ! ketal [Term] id: CHEBI:59780 name: cyclic hemiketal namespace: chebi_ontology def: "A hemiacetal having the structure R2C(OH)OR (R =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group. The term 'cyclic hemiketals', once abandoned by IUPAC, has been reinstated as a subclass of hemiacetals." [] subset: 3_STAR synonym: "cyclic hemiketals" RELATED [ChEBI] is_a: CHEBI:38131 ! lactol is_a: CHEBI:59772 ! hemiketal [Term] id: CHEBI:59792 name: thioacetal namespace: chebi_ontology def: "The sulfur analogue of 'acetal'. The term includes monothioacetals having the structure R2C(OR')(SR') (subclass monothioketals, R =/= H); and dithioacetals having the structure R2C(SR')2 (subclass dithioketals, R =/= H, R' =/= H)." [] subset: 3_STAR synonym: "thioacetals" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound [Term] id: CHEBI:59793 name: monothioacetal namespace: chebi_ontology def: "A thioacetal having the structure R2C(OR')(SR'). The term includes monothioketals, R =/= H, as a subclass." [] subset: 3_STAR synonym: "monothioacetals" RELATED [ChEBI] synonym: "thioacetal" RELATED [ChEBI] is_a: CHEBI:59792 ! thioacetal property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "COSR4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.07500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.96699" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]OC([*])([*])S[*]" xsd:string [Term] id: CHEBI:59814 name: L-alpha-amino acid anion namespace: chebi_ontology def: "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." [] subset: 3_STAR synonym: "L-alpha-amino carboxylate" RELATED [ChEBI] is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:15705 ! L-alpha-amino acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "73.051" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.01638" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H](C(=O)[O-])(N)*" xsd:string [Term] id: CHEBI:59831 name: enyne namespace: chebi_ontology def: "An acetylenic and an olefinic compound containing a carbon chain that contains a carbon-carbon double bond and a carbon-carbon triple bond." [] subset: 3_STAR synonym: "enynes" RELATED [ChEBI] is_a: CHEBI:73474 ! acetylenic compound is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:59835 name: hydroxy fatty acid anion namespace: chebi_ontology def: "The conjugate base of any hydroxy fatty acid, formed by deprotonation of the carboxylic acid moiety." [] subset: 3_STAR synonym: "hydroxy fatty acid anions" RELATED [ChEBI] synonym: "OH-FA anion" RELATED [ChEBI] synonym: "OH-FA-anions" RELATED [ChEBI] synonym: "OH-fatty acid anion" RELATED [ChEBI] synonym: "OH-fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:24654 ! hydroxy fatty acid [Term] id: CHEBI:59836 name: oxo fatty acid anion namespace: chebi_ontology def: "A fatty acid anion carrying one or more oxo substituents" [] subset: 3_STAR synonym: "oxo fatty acid anions" RELATED [ChEBI] synonym: "oxo-FA anion" RELATED [ChEBI] synonym: "oxo-FA anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion is_a: CHEBI:35903 ! oxo carboxylic acid anion relationship: is_conjugate_base_of CHEBI:59644 ! oxo fatty acid [Term] id: CHEBI:59864 name: depigmentation drug namespace: chebi_ontology def: "Any drug used to depigment skin, normally by decreasing the excretion of melanin from melanocytes." [] subset: 3_STAR synonym: "depigmentation agent" RELATED [ChEBI] synonym: "depigmentation agents" RELATED [ChEBI] synonym: "depigmentation drugs" RELATED [ChEBI] synonym: "depigmentor" RELATED [ChEBI] synonym: "depigmentors" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:59869 name: L-alpha-amino acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group." [] subset: 3_STAR synonym: "an L-alpha-amino acid" RELATED [UniProt] synonym: "L-alpha-amino acid zwitterions" RELATED [ChEBI] is_a: CHEBI:78608 ! alpha-amino acid zwitterion relationship: is_tautomer_of CHEBI:15705 ! L-alpha-amino acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H]([*])C([O-])=O" xsd:string [Term] id: CHEBI:59871 name: D-alpha-amino acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group." [] subset: 3_STAR synonym: "a D-alpha-amino acid" RELATED [UniProt] synonym: "D-alpha-amino acid zwitterions" RELATED [ChEBI] is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_tautomer_of CHEBI:16733 ! D-alpha-amino acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H]([*])C([O-])=O" xsd:string [Term] id: CHEBI:59999 name: chemical substance namespace: chebi_ontology def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." [] subset: 3_STAR synonym: "Chemische Substanz" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:60004 name: mixture namespace: chebi_ontology def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." [] subset: 3_STAR synonym: "Mischung" RELATED [ChEBI] is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:600103 name: daptomycin namespace: chebi_ontology alt_id: CHEBI:29570 alt_id: CHEBI:321017 alt_id: CHEBI:478132 alt_id: CHEBI:478255 def: "A polypeptide comprising N-decanoyltryptophan, asparagine, aspartic acid, threonine, glycine, ornithine, aspartic acid, D-alanine, aspartic acid, glycine, D-serine, threo-3-methylglutamic acid and 3-anthraniloylalanine (also known as kynurinine) coupled in sequence and lactonised by condensation of the carboxylic acid group of the 3-anthraniloylalanine with the alcohol group of the threonine residue." [] subset: 3_STAR synonym: "Cidecin" RELATED BRAND_NAME [ChemIDplus] synonym: "Cubicin" RELATED BRAND_NAME [ChemIDplus] synonym: "daptomicina" RELATED INN [ChemIDplus] synonym: "Daptomycin" EXACT [KEGG_COMPOUND] synonym: "daptomycin" EXACT [ChEMBL] synonym: "daptomycin" RELATED INN [ChemIDplus] synonym: "daptomycine" RELATED INN [ChemIDplus] synonym: "daptomycinum" RELATED INN [ChemIDplus] synonym: "LY 146032" RELATED [ChemIDplus] synonym: "N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone" RELATED [ChEBI] synonym: "N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone" RELATED [ChemIDplus] synonym: "N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine" EXACT IUPAC_NAME [IUPAC] xref: CAS:103060-53-3 {source="KEGG COMPOUND"} xref: CAS:103060-53-3 {source="ChemIDplus"} xref: DrugBank:DB00080 xref: KEGG:C12013 xref: KEGG:D01080 xref: PMID:14622998 {source="ChEMBL"} xref: PMID:15227539 {source="Europe PMC"} xref: PMID:15271343 {source="Europe PMC"} xref: PMID:15500379 {source="Europe PMC"} xref: PMID:15815985 {source="Europe PMC"} xref: PMID:15870461 {source="Europe PMC"} xref: PMID:16311632 {source="Europe PMC"} xref: PMID:17402833 {source="Europe PMC"} xref: PMID:18360590 {source="Europe PMC"} xref: PMID:18989686 {source="Europe PMC"} xref: PMID:19015332 {source="Europe PMC"} xref: PMID:19303806 {source="Europe PMC"} xref: PMID:19875242 {source="Europe PMC"} xref: PMID:20522545 {source="Europe PMC"} xref: Wikipedia:Daptomycin is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:25061 ! lipopeptide antibiotic is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:140190 ! has role calcium-dependent antibiotics relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C72H101N17O26" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DOAKLVKFURWEDJ-RWDRXURGSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1620.67060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1619.71037" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](CC(=O)c2ccccc2N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)CNC1=O)[C@H](C)CC(O)=O" xsd:string [Term] id: CHEBI:60027 name: polymer namespace: chebi_ontology def: "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." [] subset: 3_STAR synonym: "Kunststoff" RELATED [ChEBI] synonym: "Polymer" EXACT [ChEBI] xref: Wikipedia:Polymer is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:33839 ! macromolecule [Term] id: CHEBI:60039 name: L-proline zwitterion namespace: chebi_ontology alt_id: CHEBI:58054 def: "The zwitterion formed from L-proline by proton transfer from the carboxy group to the ring nitrogen. It is the predominant species at physiological pH." [] subset: 3_STAR synonym: "(2S)-pyrrolidinium-2-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "L-proline" RELATED [UniProt] xref: MetaCyc:PRO is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_tautomer_of CHEBI:17203 ! L-proline property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ONIBWKKTOPOVIA-BYPYZUCNSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "115.13050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "115.06333" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[C@@H]1CCC[NH2+]1" xsd:string [Term] id: CHEBI:600520 name: micafungin namespace: chebi_ontology alt_id: CHEBI:473847 alt_id: CHEBI:530001 alt_id: CHEBI:533643 alt_id: CHEBI:533785 def: "A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy." [] subset: 3_STAR synonym: "5-[(1S,2S)-2-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl}-1,2-dihydroxyethyl]-2-hydroxyphenyl hydrogen sulfate" EXACT IUPAC_NAME [IUPAC] synonym: "5.1:6-anhydro{(4R,5R)-4,5-dihydroxy-N(2)-(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)-L-ornithyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonyl-(3R)-3-hydroxy-L-glutaminyl-(3S,4S)-3-hydroxy-4-methyl-L-proline}" EXACT IUPAC_NAME [IUPAC] synonym: "micafungin" RELATED INN [ChemIDplus] synonym: "micafungin" RELATED INN [KEGG_DRUG] synonym: "Mycamine" RELATED [ChemIDplus] xref: Beilstein:9610508 {source="Beilstein"} xref: CAS:235114-32-6 {source="KEGG DRUG"} xref: CAS:235114-32-6 {source="ChemIDplus"} xref: DrugBank:DB01141 xref: KEGG:D08218 xref: PMID:17194830 {source="ChEMBL"} xref: PMID:17307974 {source="ChEMBL"} xref: PMID:17325217 {source="ChEMBL"} xref: PMID:17325225 {source="ChEMBL"} xref: PMID:17420211 {source="ChEMBL"} xref: PMID:17785512 {source="ChEMBL"} is_a: CHEBI:57248 ! echinocandin is_a: CHEBI:87113 ! antibiotic antifungal drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C56H71N9O23S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85)/t25-,26+,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PIEUQSKUWLMALL-YABMTYFHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1270.27400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1269.43835" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCOc1ccc(cc1)-c1cc(no1)-c1ccc(cc1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c1ccc(O)c(OS(O)(=O)=O)c1)[C@H](O)CC(N)=O" xsd:string [Term] id: CHEBI:60071 name: ertapenem(1-) namespace: chebi_ontology def: "The mono-anion resulting from the removal of a proton from one of the carboxyic acid groups of ertapenem." [] subset: 3_STAR xref: Beilstein:8177331 {source="Beilstein"} is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:404903 ! ertapenem property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H24N3O7S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H25N3O7S/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32)/p-1/t9-,10-,13+,14+,15-,16-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JUZNIMUFDBIJCM-ANEDZVCMSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "474.50700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "474.13404" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(C[NH2+][C@@]([H])(C1)C(=O)Nc1cccc(c1)C([O-])=O)SC1=C(N2C(=O)[C@]([H])([C@@H](C)O)[C@@]2([H])[C@H]1C)C([O-])=O" xsd:string [Term] id: CHEBI:60240 name: divalent metal cation namespace: chebi_ontology def: "A metal cation with a valence of two." [] subset: 3_STAR synonym: "a divalent metal cation" RELATED [UniProt] is_a: CHEBI:25213 ! metal cation is_a: CHEBI:64641 ! divalent inorganic cation [Term] id: CHEBI:60242 name: monovalent inorganic cation namespace: chebi_ontology def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." [] subset: 3_STAR synonym: "a monovalent cation" RELATED [UniProt] is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:60251 name: guanidinium ion namespace: chebi_ontology def: "R = C or H. The iminium ion resulting from the protonation of one of the imine nitrogens of guanidine or its derivatives." [] subset: 3_STAR synonym: "diaminomethaniminium ion" RELATED [ChEBI] synonym: "diaminomethaniminium ions" RELATED [ChEBI] synonym: "guanidinium ions" RELATED [ChEBI] is_a: CHEBI:35286 ! iminium ion property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHN3R5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "55.039" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "55.01705" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=[N+]([H])*)(N(*)*)N(*)*" xsd:string [Term] id: CHEBI:60258 name: EC 3.4.* (hydrolases acting on peptide bond) inhibitor namespace: chebi_ontology alt_id: CHEBI:76763 def: "A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*)." [] subset: 3_STAR synonym: "EC 3.4.* (hydrolase acting on peptide bond) inhibitor" RELATED [ChEBI] synonym: "EC 3.4.* (hydrolase acting on peptide bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.* (hydrolases acting on peptide bond) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.* (peptidase) inhibitor" RELATED [ChEBI] synonym: "EC 3.4.* (peptidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.* inhibitor" RELATED [ChEBI] synonym: "EC 3.4.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI] synonym: "inhibitors of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI] synonym: "peptidase inhibitors" RELATED [ChEBI] synonym: "protease inhibitor" RELATED [ChEBI] synonym: "protease inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:6030 name: isoniazide namespace: chebi_ontology def: "A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine." [] subset: 3_STAR synonym: "4-pyridinecarbohydrazide" RELATED [ChEBI] synonym: "Isoniazid" RELATED [KEGG_COMPOUND] synonym: "isoniazid" RELATED [UniProt] synonym: "isonicotinic acid hydrazide" RELATED [NIST_Chemistry_WebBook] synonym: "isonicotinic hydrazide" RELATED [ChEBI] synonym: "isonicotinohydrazide" RELATED [NIST_Chemistry_WebBook] synonym: "isonicotinoylhydrazide" RELATED [IUPAC] synonym: "Isonicotinsaeurehydrazid" RELATED [ChEBI] synonym: "pyridine-4-carbohydrazide" EXACT IUPAC_NAME [IUPAC] synonym: "pyridine-4-carboxylic acid hydrazide" RELATED [ChEBI] xref: Beilstein:119374 {source="Beilstein"} xref: CAS:54-85-3 {source="KEGG COMPOUND"} xref: CAS:54-85-3 {source="NIST Chemistry WebBook"} xref: CAS:54-85-3 {source="ChemIDplus"} xref: Drug_Central:1497 {source="DrugCentral"} xref: DrugBank:DB00951 xref: Gmelin:82804 {source="Gmelin"} xref: KEGG:C07054 xref: KEGG:D00346 xref: LINCS:LSM-6682 xref: MetaCyc:ISONIAZIDE xref: PMID:15013786 {source="Europe PMC"} xref: PMID:18220565 {source="Europe PMC"} xref: PMID:19183459 {source="Europe PMC"} xref: PMID:445303 {source="Europe PMC"} xref: Reaxys:119374 {source="Reaxys"} xref: Wikipedia:Isoniazid is_a: CHEBI:35363 ! carbohydrazide relationship: has_functional_parent CHEBI:6032 ! isonicotinic acid relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:88188 ! has role drug allergen property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H7N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QRXWMOHMRWLFEY-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "137.13930" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "137.05891" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NNC(=O)c1ccncc1" xsd:string [Term] id: CHEBI:6032 name: isonicotinic acid namespace: chebi_ontology def: "A pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring." [] subset: 3_STAR synonym: "4-carboxypyridine" RELATED [NIST_Chemistry_WebBook] synonym: "4-pyridinecarboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "gamma-picolinic acid" RELATED [NIST_Chemistry_WebBook] synonym: "gamma-pyridinecarboxylic acid" RELATED [ChemIDplus] synonym: "Isonicotinic acid" EXACT [KEGG_COMPOUND] synonym: "isonicotinic acid" EXACT IUPAC_NAME [IUPAC] synonym: "p-pyridinecarboxylic acid" RELATED [ChemIDplus] synonym: "pyridine-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC] xref: Beilstein:109599 {source="Beilstein"} xref: CAS:55-22-1 {source="NIST Chemistry WebBook"} xref: CAS:55-22-1 {source="ChemIDplus"} xref: CAS:55-22-1 {source="KEGG COMPOUND"} xref: Gmelin:68876 {source="Gmelin"} xref: HMDB:HMDB0060665 xref: KEGG:C07446 xref: PMID:13115353 {source="Europe PMC"} xref: PMID:22537922 {source="Europe PMC"} xref: PMID:23832340 {source="Europe PMC"} xref: PMID:23929452 {source="Europe PMC"} xref: Reaxys:109599 {source="Reaxys"} xref: Wikipedia:Isonicotinic_Acid is_a: CHEBI:26420 ! pyridinemonocarboxylic acid relationship: is_conjugate_acid_of CHEBI:38186 ! isonicotinate relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H5NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TWBYWOBDOCUKOW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "123.10940" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "123.03203" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1ccncc1" xsd:string [Term] id: CHEBI:60334 name: peptide anion namespace: chebi_ontology def: "An anion formed by deprotonation of at least one peptide carboxy group." [] subset: 3_STAR synonym: "peptide anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion [Term] id: CHEBI:60466 name: peptide zwitterion namespace: chebi_ontology def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." [] subset: 3_STAR synonym: "a peptide" RELATED [UniProt] synonym: "peptide zwitterions" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:16670 ! peptide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R(C2H2NOR)n" xsd:string [Term] id: CHEBI:60600 name: amide fungicide namespace: chebi_ontology def: "Compounds that contain an amide group as a key feature of their structure and which have been used as fungicides." [] subset: 3_STAR synonym: "amide fungicides" RELATED [ChEBI] is_a: CHEBI:87012 ! amide antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:60643 name: NMDA receptor antagonist namespace: chebi_ontology alt_id: CHEBI:60797 def: "Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs." [] subset: 3_STAR synonym: "N-methyl-D-aspartate receptor antagonist" RELATED [ChEBI] synonym: "N-methyl-D-aspartate receptor antagonists" RELATED [ChEBI] synonym: "NMDA receptor antagonists" RELATED [ChEBI] synonym: "NMDAR antagonist" RELATED [ChEBI] synonym: "NMDAR antagonists" RELATED [ChEBI] is_a: CHEBI:60798 ! excitatory amino acid antagonist [Term] id: CHEBI:60690 name: nitrogen-containing fatty acid namespace: chebi_ontology def: "Any fatty acid containing nitrogen as either a substituent or a replacement for a methylene carbon." [] subset: 3_STAR synonym: "N-containing fatty acid" RELATED [ChEBI] synonym: "N-containing fatty acids" RELATED [ChEBI] synonym: "nitrogen-containing fatty acids" RELATED [ChEBI] is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:61008 ! nitrogen-containing fatty acid anion [Term] id: CHEBI:6076 name: itraconazole namespace: chebi_ontology def: "An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis." [] subset: 3_STAR synonym: "2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one" EXACT IUPAC_NAME [IUPAC] synonym: "Itraconazole" EXACT [KEGG_DRUG] synonym: "itraconazole" EXACT [UniProt] synonym: "Itrizole (TN)" RELATED [KEGG_DRUG] synonym: "Oriconazole" RELATED [ChemIDplus] synonym: "Sporanox (TN)" RELATED [KEGG_DRUG] xref: CAS:84625-61-6 {source="KEGG DRUG"} xref: CAS:84625-61-6 {source="ChemIDplus"} xref: DrugBank:DB01167 xref: KEGG:D00350 xref: Patent:EP6711 xref: Patent:US4267179 xref: PMID:11219548 {source="Europe PMC"} xref: PMID:11403818 {source="Europe PMC"} xref: PMID:11422002 {source="Europe PMC"} xref: PMID:15521894 {source="Europe PMC"} xref: PMID:19025521 {source="Europe PMC"} xref: PMID:20400651 {source="Europe PMC"} xref: PMID:25326091 {source="Europe PMC"} xref: VSDB:1853 xref: Wikipedia:Itraconazole is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: RO:0000087 CHEBI:140921 ! has role Hedgehog signaling pathway inhibitor relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C35H38Cl2N8O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VHVPQPYKVGDNFY-ZPGVKDDISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "705.63300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "704.23931" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OC[C@H]3CO[C@@](Cn4cncn4)(O3)c3ccc(Cl)cc3Cl)cc2)c1=O" xsd:string [Term] id: CHEBI:60783 name: nucleoside analogue namespace: chebi_ontology def: "An analogue of a nucleoside, being an N-glycosyl compound in which the nitrogen-containing moiety is a modified nucleotide base. They are commonly used as antiviral products to prevent viral replication in infected cells." [] subset: 3_STAR synonym: "nucleoside analogues" RELATED [ChEBI] is_a: CHEBI:21731 ! N-glycosyl compound [Term] id: CHEBI:60798 name: excitatory amino acid antagonist namespace: chebi_ontology def: "Any substance which inhibits the action of receptors for excitatory amino acids." [] subset: 3_STAR synonym: "EAA receptor antagonist" RELATED [ChEBI] synonym: "EAA receptor antagonists" RELATED [ChEBI] synonym: "excitatory amino acid antagonists" RELATED [ChEBI] synonym: "excitatory amino acid receptor antagonist" RELATED [ChEBI] synonym: "excitatory amino acid receptor antagonists" RELATED [ChEBI] is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:60809 name: adjuvant namespace: chebi_ontology def: "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." [] subset: 3_STAR synonym: "adjuvants" RELATED [ChEBI] is_a: CHEBI:52217 ! pharmaceutical [Term] id: CHEBI:60832 name: tubulin modulator namespace: chebi_ontology def: "Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules." [] subset: 3_STAR synonym: "tubulin modulators" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:60895 name: D-alpha-amino acid anion namespace: chebi_ontology def: "Any alpha-amino acid anion in which the parent amino acid has D-configuration." [] subset: 3_STAR synonym: "D-alpha-amino acid anions" RELATED [ChEBI] synonym: "D-alpha-amino carboxylate" RELATED [ChEBI] is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:16733 ! D-alpha-amino acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "73.051" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.01638" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H](C(=O)[O-])(N)*" xsd:string [Term] id: CHEBI:60911 name: racemate namespace: chebi_ontology def: "A racemate is an equimolar mixture of a pair of enantiomers." [] subset: 3_STAR synonym: "melange racemique" RELATED [ChEBI] synonym: "racemates" RELATED [ChEBI] synonym: "racemic mixture" RELATED [ChEBI] is_a: CHEBI:60004 ! mixture [Term] id: CHEBI:60915 name: diastereoisomeric mixture namespace: chebi_ontology def: "A mixture composed of two or more diastereoisomers (stereoisomers not related as mirror images)." [] subset: 3_STAR synonym: "diastereomeric mixture" RELATED [ChEBI] is_a: CHEBI:60004 ! mixture [Term] id: CHEBI:60926 name: amino monosaccharide namespace: chebi_ontology def: "Any amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group." [] subset: 3_STAR synonym: "amino monosaccharides" RELATED [ChEBI] is_a: CHEBI:28963 ! amino sugar [Term] id: CHEBI:60979 name: alpha-glucoside namespace: chebi_ontology def: "A glucoside in which the anomeric carbon of the glycosidic bond is in an alpha configuration" [] subset: 3_STAR synonym: "alpha-glucosides" RELATED [ChEBI] is_a: CHEBI:24278 ! glucoside [Term] id: CHEBI:61007 name: amino fatty acid anion namespace: chebi_ontology def: "A nitrogen-containing fatty acid anion arising from deprotonation of the carboxy group of any amino fatty acid." [] subset: 3_STAR synonym: "amino FA anion" RELATED [ChEBI] synonym: "amino FA anions" RELATED [ChEBI] synonym: "amino fatty acid anions" RELATED [ChEBI] synonym: "NH2-FA anion" RELATED [ChEBI] synonym: "NH2-FA anions" RELATED [ChEBI] synonym: "NH2-fatty acid anion" RELATED [ChEBI] synonym: "NH2-fatty acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion is_a: CHEBI:61008 ! nitrogen-containing fatty acid anion relationship: is_conjugate_base_of CHEBI:59650 ! amino fatty acid [Term] id: CHEBI:61008 name: nitrogen-containing fatty acid anion namespace: chebi_ontology def: "A fatty acid anion arising from deprotonation of the carboxylic acid group of any nitrogen-containing fatty acid." [] subset: 3_STAR synonym: "N-containing FA anion" RELATED [ChEBI] synonym: "N-containing FA anions" RELATED [ChEBI] synonym: "N-containing fatty acid anions" RELATED [ChEBI] synonym: "nitrogen-containing FA anion" RELATED [ChEBI] synonym: "nitrogen-containing FA anions" RELATED [ChEBI] synonym: "nitrogen-containing fatty acid anion" EXACT [ChEBI] synonym: "nitrogen-containing fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:60690 ! nitrogen-containing fatty acid [Term] id: CHEBI:61015 name: nephrotoxin namespace: chebi_ontology def: "A poison that interferes with the function of the kidneys." [] subset: 3_STAR synonym: "nephrotoxins" RELATED [ChEBI] is_a: CHEBI:50909 ! nephrotoxic agent is_a: CHEBI:64909 ! poison [Term] id: CHEBI:61115 name: EC 3.5.1.98 (histone deacetylase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98)." [] subset: 3_STAR synonym: "EC 3.5.1.98 (histone deacetylase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.98 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.98 inhibitors" RELATED [ChEBI] synonym: "HDAC inhibitor" RELATED [ChEBI] synonym: "HDAC inhibitors" RELATED [ChEBI] synonym: "HDACi" RELATED [ChEBI] synonym: "HDACis" RELATED [ChEBI] synonym: "HDI" RELATED [ChEBI] synonym: "HDIs" RELATED [ChEBI] synonym: "histone amidohydrolase inhibitor" RELATED [ChEBI] synonym: "histone amidohydrolase inhibitors" RELATED [ChEBI] synonym: "histone deacetylase (EC 3.5.1.98) inhibitor" RELATED [ChEBI] synonym: "histone deacetylase (EC 3.5.1.98) inhibitors" RELATED [ChEBI] synonym: "histone deacetylase inhibitor" RELATED [ChEBI] synonym: "histone deacetylase inhibitors" RELATED [ChEBI] xref: Wikipedia:Histone_deacetylase_inhibitor is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:61120 name: nucleobase-containing molecular entity namespace: chebi_ontology def: "Any compound that has a nucleobase as a part." [] subset: 3_STAR synonym: "nucleobase-containing compound" RELATED [SUBMITTER] synonym: "nucleobase-containing compounds" RELATED [ChEBI] synonym: "nucleobase-containing molecular entities" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_functional_parent CHEBI:18282 ! nucleobase [Term] id: CHEBI:61293 name: adenyl nucleotide namespace: chebi_ontology def: "A nucleotide having adenine as the base." [] subset: 3_STAR synonym: "adenine nucleotide" RELATED [SUBMITTER] is_a: CHEBI:26395 ! purine nucleotide [Term] id: CHEBI:61296 name: adenyl ribonucleotide namespace: chebi_ontology def: "A purine riboncleotide where adenine is the purine." [] subset: 3_STAR synonym: "adenine ribonucleotide" RELATED [SUBMITTER] is_a: CHEBI:26400 ! purine ribonucleotide is_a: CHEBI:61293 ! adenyl nucleotide [Term] id: CHEBI:61689 name: amino cyclitol namespace: chebi_ontology def: "Any cyclitol having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." [] subset: 3_STAR synonym: "amino cyclitols" RELATED [ChEBI] synonym: "aminocyclitol" RELATED [ChEBI] synonym: "aminocyclitols" RELATED [ChEBI] is_a: CHEBI:23451 ! cyclitol [Term] id: CHEBI:61739 name: aureobasidin A namespace: chebi_ontology def: "A cyclodepsipeptide antibiotic, which is isolated from the filamentous fungus Aureobasidium pullulans R106 and is toxic to yeast at low concentrations (0.1-0.5 ug/ml)." [] subset: 3_STAR synonym: "(3R,6S,9S,12S,15S,21S,24S,29aS)-21,24-dibenzyl-15-[(2R)-butan-2-yl]-9-isobutyl-6,12,18-triisopropyl-5,11,23-trimethyl-3-[(2R)-3-methylbutan-2-yl]octadecahydro-1H,15H-pyrrolo[1,2-m][1,4,7,10,13,16,19,22,25]oxaoctaazacycloheptacosine-1,4,7,10,13,16,19,22,25-nonone" EXACT IUPAC_NAME [IUPAC] synonym: "(3S,6S,9S,12S,15S,18S,21S,24R,27S)-12,24-bis[(2R)-butan-2-yl]-15-(2-hydroxypropan-2-yl)-4,10,16,22-tetramethyl-18-(2-methylpropyl)-3,6-bis(phenylmethyl)-9,21-di(propan-2-yl)-13-oxa-1,4,7,10,16,19,22,25-octazabicyclo[25.3.0]triacontane-2,5,8,11,14,17,20,23,26-nonone" RELATED [SUBMITTER] synonym: "Antibiotic R106I" RELATED [ChEBI] synonym: "basifungin" RELATED INN [ChemIDplus] synonym: "N-((2R,3R)-2-hydroxy-3-methylvaleryl)-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl-L- alloisoleucyl-N-methyl-L-valyl-L-leucyl-3-hydroxy-N-methyl- L-valine alpha1-lactone" RELATED [ChemIDplus] xref: CAS:127785-64-2 {source="SUBMITTER"} is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:35213 ! cyclodepsipeptide relationship: RO:0000087 CHEBI:61774 ! has role inositol phosphorylceramide synthase inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C60H92N8O10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C60H92N8O10/c1-17-39(12)51-55(72)63-47(36(6)7)53(70)61-44(32-41-25-20-18-21-26-41)56(73)65(14)46(33-42-27-22-19-23-28-42)58(75)68-30-24-29-45(68)52(69)64-48(40(13)35(4)5)59(76)66(15)49(37(8)9)54(71)62-43(31-34(2)3)57(74)67(16)50(38(10)11)60(77)78-51/h18-23,25-28,34-40,43-51H,17,24,29-33H2,1-16H3,(H,61,70)(H,62,71)(H,63,72)(H,64,69)/t39-,40-,43+,44+,45+,46+,47?,48-,49+,50+,51+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YHSKJPXGXIYLHB-OTNPUQRPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1085.42010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1084.69364" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)C(NC1=O)C(C)C)[C@H](C)C(C)C" xsd:string [Term] id: CHEBI:61774 name: inositol phosphorylceramide synthase inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of inositol phosphorylceramide synthase." [] subset: 3_STAR xref: PMID:17420564 {source="Europe PMC"} xref: PMID:17420565 {source="Europe PMC"} xref: PMID:19644518 {source="Europe PMC"} xref: PMID:19644519 {source="Europe PMC"} xref: PMID:19662087 {source="Europe PMC"} is_a: CHEBI:76881 ! EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor [Term] id: CHEBI:61951 name: microtubule-destabilising agent namespace: chebi_ontology def: "Any substance that interacts with tubulin to inhibit polymerisation of microtubules." [] subset: 3_STAR synonym: "microtubule destabilising agent" RELATED [ChEBI] synonym: "microtubule destabilising agents" RELATED [ChEBI] synonym: "microtubule destabilising role" RELATED [ChEBI] synonym: "microtubule destabilizing role" RELATED [SUBMITTER] synonym: "microtubule-destabilising agents" RELATED [ChEBI] synonym: "microtubule-destabilizing agent" RELATED [ChEBI] synonym: "microtubule-destabilizing agents" RELATED [ChEBI] xref: PMID:17099073 {source="Europe PMC"} is_a: CHEBI:60832 ! tubulin modulator is_a: CHEBI:64911 ! antimitotic [Term] id: CHEBI:62031 name: polar amino acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." [] subset: 2_STAR synonym: "a polar amino acid" RELATED [UniProt] xref: MetaCyc:Polar-amino-acids {source="SUBMITTER"} is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_tautomer_of CHEBI:26167 ! polar amino acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C([O-])=O)(*)[NH3+]" xsd:string [Term] id: CHEBI:62070 name: nalidixic acid anion namespace: chebi_ontology def: "A monocarboxylic acid anion that is the conjugate base of nalidixic acid; major species at pH 7.3." [] subset: 3_STAR synonym: "1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "nalidixate" RELATED [ChEBI] synonym: "nalidixate anion" RELATED [ChEBI] synonym: "nalidixate(1-)" RELATED [ChEBI] synonym: "nalidixylate" RELATED [SUBMITTER] xref: PMID:10793679 {source="Europe PMC"} xref: PMID:16107187 {source="Europe PMC"} xref: PMID:375215 {source="Europe PMC"} xref: PMID:6283318 {source="Europe PMC"} xref: PMID:673862 {source="Europe PMC"} xref: PMID:766016 {source="Europe PMC"} xref: PMID:785214 {source="Europe PMC"} xref: PMID:8893520 {source="Europe PMC"} xref: Reaxys:3556893 {source="Reaxys"} is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:100147 ! nalidixic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H11N2O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MHWLWQUZZRMNGJ-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "231.22730" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "231.07752" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCn1cc(C([O-])=O)c(=O)c2ccc(C)nc12" xsd:string [Term] id: CHEBI:62220 name: pyocyanine(1+) namespace: chebi_ontology def: "An organic cation resulting from the protonation of pyocyanin." [] subset: 3_STAR synonym: "1-hydroxy-5-methylphenazin-5-ium" EXACT IUPAC_NAME [IUPAC] synonym: "5-methylphenazin-1(5H)-one" RELATED [MetaCyc] synonym: "pyocyanin" RELATED [UniProt] synonym: "pyocyanin(1+)" RELATED [ChEBI] xref: MetaCyc:CPD-12847 {source="SUBMITTER"} xref: PMID:14210570 {source="Europe PMC"} xref: PMID:1500199 {source="Europe PMC"} xref: PMID:17253782 {source="SUBMITTER"} xref: PMID:19869911 {source="Europe PMC"} xref: PMID:2106495 {source="Europe PMC"} xref: PMID:2422042 {source="Europe PMC"} xref: PMID:2547716 {source="Europe PMC"} xref: PMID:3028961 {source="Europe PMC"} xref: PMID:3150520 {source="Europe PMC"} xref: PMID:415847 {source="Europe PMC"} xref: PMID:4202997 {source="Europe PMC"} xref: PMID:4977219 {source="Europe PMC"} xref: PMID:6243619 {source="Europe PMC"} xref: PMID:6774217 {source="Europe PMC"} xref: PMID:6782436 {source="Europe PMC"} xref: PMID:9078238 {source="Europe PMC"} xref: Reaxys:3908208 {source="Reaxys"} is_a: CHEBI:25697 ! organic cation is_a: CHEBI:39201 ! phenazines relationship: is_conjugate_acid_of CHEBI:8653 ! pyocyanine property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H11N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3/p+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YNCMLFHHXWETLD-UHFFFAOYSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "211.23920" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "211.08659" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[n+]1c2ccccc2nc2c(O)cccc12" xsd:string [Term] id: CHEBI:62247 name: (1R,2S)-epoxypropylphosphonate(1-) namespace: chebi_ontology def: "An organophosphonate oxoanion obtained by deprotonation of one of the two phosphonate OH groups of (1R,2S)-epoxypropylphosphonic acid; major species at pH 7.3." [] subset: 3_STAR synonym: "(1R,2S)-epoxypropylphosphonate" RELATED [UniProt] synonym: "fosfomycin" RELATED [SUBMITTER] synonym: "fosfomycin(1-)" RELATED [ChEBI] synonym: "hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate" EXACT IUPAC_NAME [IUPAC] xref: MetaCyc:CPD0-1113 xref: PMID:18656958 {source="SUBMITTER"} is_a: CHEBI:59635 ! organophosphonate oxoanion relationship: is_conjugate_acid_of CHEBI:62419 ! (1R,2S)-epoxypropylphosphonate(2-) relationship: is_conjugate_base_of CHEBI:28915 ! fosfomycin relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6O4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/p-1/t2-,3+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YMDXZJFXQJVXBF-STHAYSLISA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "137.05110" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "137.00092" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H]1O[C@@H]1P(O)([O-])=O" xsd:string [Term] id: CHEBI:623918 name: nikkomycin Z namespace: chebi_ontology alt_id: CHEBI:109145 alt_id: CHEBI:621961 def: "A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase." [] subset: 3_STAR synonym: "(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-beta-D-allo-furanuronic acid" RELATED [ChEBI] synonym: "(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]acetic acid" RELATED [ChEBI] synonym: "Neopolyoxin C" RELATED [ChemIDplus] synonym: "Nikkomycin" RELATED [ChemIDplus] xref: Beilstein:4303204 {source="Beilstein"} xref: CAS:59456-70-1 {source="ChemIDplus"} xref: PMID:10888330 {source="ChEMBL"} xref: PMID:12205060 {source="Europe PMC"} xref: PMID:12729648 {source="ChEMBL"} xref: PMID:1992114 {source="ChEMBL"} xref: PMID:19930628 {source="Europe PMC"} xref: PMID:20931236 {source="Europe PMC"} xref: PMID:22203603 {source="Europe PMC"} xref: Reaxys:4303204 {source="Reaxys"} is_a: CHEBI:59668 ! nikkomycin relationship: has_functional_parent CHEBI:16704 ! uridine relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H25N5O10" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12-,13-,14-,15+,16+,18+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WWJFFVUVFNBJTN-VHDFTHOZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "495.44000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "495.16014" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)[C@H](NC(=O)[C@@H](N)[C@H](C)[C@H](O)c1ccc(O)cn1)C(O)=O" xsd:string [Term] id: CHEBI:62419 name: (1R,2S)-epoxypropylphosphonate(2-) namespace: chebi_ontology def: "An organophosphonate oxoanion obtained by deprotonation of the two phosphonate OH groups of (1R,2S)-epoxypropylphosphonic acid." [] subset: 3_STAR synonym: "(1R,2S)-epoxypropylphosphonate" RELATED [ChEBI] synonym: "(1R,2S)-epoxypropylphosphonate dianion" RELATED [ChEBI] synonym: "[(2R,3S)-3-methyloxiran-2-yl]phosphonate" EXACT IUPAC_NAME [IUPAC] synonym: "fosfomycin" RELATED [ChEBI] synonym: "fosfomycin dianion" RELATED [ChEBI] synonym: "fosfomycin(2-)" RELATED [ChEBI] xref: PMID:10681332 {source="Europe PMC"} xref: PMID:18656958 {source="Europe PMC"} xref: PMID:3637200 {source="Europe PMC"} xref: PMID:3782953 {source="Europe PMC"} xref: PMID:3900283 {source="Europe PMC"} xref: PMID:6357073 {source="Europe PMC"} xref: PMID:6440482 {source="Europe PMC"} xref: PMID:6725145 {source="Europe PMC"} xref: PMID:6739142 {source="Europe PMC"} xref: PMID:832538 {source="Europe PMC"} is_a: CHEBI:71285 ! organophosphonate(2-) relationship: is_conjugate_base_of CHEBI:62247 ! (1R,2S)-epoxypropylphosphonate(1-) property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H5O4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/p-2/t2-,3+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YMDXZJFXQJVXBF-STHAYSLISA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "136.04320" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "135.99364" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H]1O[C@@H]1P([O-])([O-])=O" xsd:string [Term] id: CHEBI:62488 name: signalling molecule namespace: chebi_ontology def: "A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell." [] subset: 3_STAR synonym: "signal molecule" RELATED [ChEBI] synonym: "signal molecules" RELATED [ChEBI] synonym: "signaling molecule" RELATED [ChEBI] synonym: "signaling molecules" RELATED [ChEBI] synonym: "signalling molecules" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger [Term] id: CHEBI:62643 name: anionic phospholipid namespace: chebi_ontology def: "Any organophosphate oxoanion that is a negatively charged phospholipid, e.g. phosphatidylserine(1-), phosphatidate(2-), phosphatidylglycerol(1-)." [] subset: 3_STAR synonym: "anionic phospholipids" RELATED [ChEBI] synonym: "phospholipid anion" RELATED [ChEBI] synonym: "phospholipid anions" RELATED [ChEBI] is_a: CHEBI:58945 ! organophosphate oxoanion relationship: is_conjugate_base_of CHEBI:16247 ! phospholipid [Term] id: CHEBI:62733 name: aromatic amide namespace: chebi_ontology def: "An amide in which the amide linkage is bonded directly to an aromatic system." [] subset: 3_STAR synonym: "aromatic amides" RELATED [ChEBI] is_a: CHEBI:32988 ! amide is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:62868 name: hepatoprotective agent namespace: chebi_ontology def: "Any compound that is able to prevent damage to the liver." [] subset: 3_STAR synonym: "antihepatotoxic agent" RELATED [ChEBI] synonym: "hepatoprotective agents" RELATED [ChEBI] synonym: "hepatoprotector" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:62872 name: EC 1.2.3.1 (aldehyde oxidase) inhibitor namespace: chebi_ontology def: "An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1)." [] subset: 3_STAR synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitor" RELATED [ChEBI] synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitors" RELATED [ChEBI] synonym: "aldehyde oxidase inhibitor" RELATED [ChEBI] synonym: "aldehyde oxidase inhibitors" RELATED [ChEBI] synonym: "aldehyde:oxygen oxidoreductase inhibitor" RELATED [ChEBI] synonym: "aldehyde:oxygen oxidoreductase inhibitors" RELATED [ChEBI] synonym: "EC 1.2.3.1 (aldehyde oxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.3.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.2.3.1 inhibitors" RELATED [ChEBI] synonym: "quinoline oxidase inhibitor" RELATED [ChEBI] synonym: "quinoline oxidase inhibitors" RELATED [ChEBI] synonym: "retinal oxidase inhibitor" RELATED [ChEBI] synonym: "retinal oxidase inhibitors" RELATED [ChEBI] synonym: "retinoic acid synthase inhibitor" RELATED [ChEBI] synonym: "retinoic acid synthase inhibitors" RELATED [ChEBI] xref: Wikipedia:Aldehyde_oxidase is_a: CHEBI:76853 ! EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor [Term] id: CHEBI:62913 name: EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD(+) ADP-ribosyltransferase (EC 2.4.2.30)." [] subset: 3_STAR synonym: "ADP-ribosyltransferase (polymerising) inhibitor" RELATED [ChEBI] synonym: "ADP-ribosyltransferase (polymerising) inhibitors" RELATED [ChEBI] synonym: "ADP-ribosyltransferase (polymerizing) inhibitor" RELATED [ChEBI] synonym: "ADP-ribosyltransferase (polymerizing) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.2.30 inhibitor" RELATED [ChEBI] synonym: "EC 2.4.2.30 inhibitors" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitor" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitors" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase inhibitor" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase inhibitors" RELATED [ChEBI] synonym: "NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor" RELATED [ChEBI] synonym: "NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors" RELATED [ChEBI] synonym: "NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor" RELATED [ChEBI] synonym: "NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors" RELATED [ChEBI] synonym: "PARP" RELATED [ChEBI] synonym: "PARPs" RELATED [ChEBI] synonym: "poly(adenosine diphosphate ribose) polymerase inhibitor" RELATED [ChEBI] synonym: "poly(adenosine diphosphate ribose) polymerase inhibitors" RELATED [ChEBI] synonym: "poly(ADP-ribose) polymerase inhibitor" RELATED [ChEBI] synonym: "poly(ADP-ribose) polymerase inhibitors" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthase inhibitor" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthase inhibitors" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthetase inhibitor" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthetase inhibitors" RELATED [ChEBI] xref: Wikipedia:PARP_inhibitor is_a: CHEBI:76790 ! EC 2.4.2.* (pentosyltransferase) inhibitor [Term] id: CHEBI:63046 name: emulsifier namespace: chebi_ontology def: "The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability." [] subset: 3_STAR synonym: "emulgent" RELATED [ChEBI] synonym: "emulgents" RELATED [ChEBI] synonym: "emulsifiers" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63161 name: glycosyl compound namespace: chebi_ontology def: "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." [] subset: 3_STAR synonym: "glycosyl compounds" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:63247 name: reducing agent namespace: chebi_ontology def: "The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species." [] subset: 3_STAR synonym: "reducer" RELATED [ChEBI] synonym: "reducers" RELATED [ChEBI] synonym: "reducing agents" RELATED [ChEBI] synonym: "reductant" RELATED [ChEBI] synonym: "reductants" RELATED [ChEBI] xref: Wikipedia:Reducing_agent is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63248 name: oxidising agent namespace: chebi_ontology def: "A substance that removes electrons from another reactant in a redox reaction." [] subset: 3_STAR synonym: "oxidant" RELATED [ChEBI] synonym: "oxidants" RELATED [ChEBI] synonym: "oxidiser" RELATED [ChEBI] synonym: "oxidisers" RELATED [ChEBI] synonym: "oxidising agents" RELATED [ChEBI] synonym: "oxidizer" RELATED [ChEBI] synonym: "oxidizers" RELATED [ChEBI] synonym: "oxidizing agent" RELATED [ChEBI] synonym: "oxidizing agents" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63299 name: carbohydrate derivative namespace: chebi_ontology def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." [] subset: 3_STAR synonym: "carbohydrate derivatives" RELATED [ChEBI] synonym: "derivatised carbohydrate" RELATED [ChEBI] synonym: "derivatised carbohydrates" RELATED [ChEBI] synonym: "derivatized carbohydrate" RELATED [ChEBI] synonym: "derivatized carbohydrates" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives relationship: has_functional_parent CHEBI:16646 ! carbohydrate [Term] id: CHEBI:63353 name: disaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a disaccharide." [] subset: 3_STAR synonym: "disaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:36233 ! disaccharide [Term] id: CHEBI:63367 name: monosaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a monosaccharide." [] subset: 3_STAR synonym: "monosaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:35381 ! monosaccharide [Term] id: CHEBI:63409 name: pentose derivative namespace: chebi_ontology def: "A monosaccharide derivative that is formally obtained from a pentose." [] subset: 3_STAR synonym: "pentose derivatives" RELATED [ChEBI] is_a: CHEBI:63367 ! monosaccharide derivative relationship: has_functional_parent CHEBI:25901 ! pentose [Term] id: CHEBI:63473 name: aromatic amino-acid anion namespace: chebi_ontology def: "An aromatic amino acid whose alpha-carboxylic acid group is ionized (non-protonated)." [] subset: 3_STAR synonym: "aromatic amino-acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33856 ! aromatic amino acid [Term] id: CHEBI:63490 name: explosive namespace: chebi_ontology def: "A substance capable of undergoing rapid and highly exothermic decomposition." [] subset: 3_STAR synonym: "explosive compound" RELATED [ChEBI] synonym: "explosive compounds" RELATED [ChEBI] synonym: "explosive material" RELATED [ChEBI] synonym: "explosives" RELATED [ChEBI] synonym: "explosives chemical" RELATED [ChEBI] synonym: "explosives chemicals" RELATED [ChEBI] xref: Wikipedia:Explosive_material is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63598 name: levofloxacin namespace: chebi_ontology alt_id: CHEBI:6440 def: "An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase." [] subset: 3_STAR synonym: "(-)-Ofloxacin" RELATED [ChemIDplus] synonym: "(-)-ofloxacin" RELATED [ChEBI] synonym: "(3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid" RELATED [ChEBI] synonym: "(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "(S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid" RELATED [ChEBI] synonym: "(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid" RELATED [ChemIDplus] synonym: "(S)-ofloxacin" RELATED [ChemIDplus] synonym: "DR 3355" RELATED [ChEBI] synonym: "DR-3355" RELATED [ChEBI] synonym: "L-ofloxacin" RELATED [DrugBank] synonym: "levofloxacin" RELATED INN [KEGG_DRUG] synonym: "levofloxacine" RELATED INN [ChemIDplus] synonym: "levofloxacino" RELATED INN [ChemIDplus] synonym: "levofloxacinum" RELATED INN [ChemIDplus] synonym: "Ofloxacin S-(-)-form" RELATED [KEGG_COMPOUND] synonym: "S-(-)-ofloxacin" RELATED [ChEBI] xref: CAS:100986-85-4 {source="KEGG COMPOUND"} xref: CAS:100986-85-4 {source="ChemIDplus"} xref: Drug_Central:1569 {source="DrugCentral"} xref: DrugBank:DB01137 xref: HMDB:HMDB0001929 xref: KEGG:C07660 xref: KEGG:D08120 xref: LINCS:LSM-5270 xref: PDBeChem:LFX xref: PMID:10803495 {source="Europe PMC"} xref: PMID:11141388 {source="Europe PMC"} xref: PMID:11181130 {source="Europe PMC"} xref: PMID:11249554 {source="Europe PMC"} xref: PMID:11558453 {source="Europe PMC"} xref: PMID:11898264 {source="Europe PMC"} xref: PMID:11975700 {source="Europe PMC"} xref: PMID:14581720 {source="Europe PMC"} xref: PMID:15969945 {source="Europe PMC"} xref: PMID:17549677 {source="Europe PMC"} xref: PMID:19212411 {source="Europe PMC"} xref: PMID:20596531 {source="Europe PMC"} xref: PMID:2079448 {source="Europe PMC"} xref: PMID:21075586 {source="Europe PMC"} xref: PMID:21965436 {source="Europe PMC"} xref: PMID:21974858 {source="Europe PMC"} xref: PMID:22088660 {source="Europe PMC"} xref: PMID:22221614 {source="Europe PMC"} xref: PMID:23965305 {source="Europe PMC"} xref: PMID:26792525 {source="Europe PMC"} xref: PMID:27050128 {source="Europe PMC"} xref: PMID:34323366 {source="Europe PMC"} xref: PMID:34824229 {source="Europe PMC"} xref: PMID:36076992 {source="Europe PMC"} xref: PMID:36102678 {source="Europe PMC"} xref: PMID:36119964 {source="Europe PMC"} xref: PMID:36135690 {source="Europe PMC"} xref: PMID:36314364 {source="Europe PMC"} xref: PMID:36328279 {source="Europe PMC"} xref: PMID:8656585 {source="Europe PMC"} xref: PMID:8957581 {source="Europe PMC"} xref: PMID:9068926 {source="Europe PMC"} xref: PMID:9624783 {source="Europe PMC"} xref: Reaxys:5385660 {source="Reaxys"} xref: VSDB:1899 xref: Wikipedia:Levofloxacin is_a: CHEBI:194135 ! 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_enantiomer_of CHEBI:46577 ! dextrofloxacin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H20FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GSDSWSVVBLHKDQ-JTQLQIEISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "361.373" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "361.14378" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H]1COC2=C(N3CCN(C)CC3)C(F)=CC3=C2N1C=C(C(O)=O)C3=O" xsd:string [Term] id: CHEBI:63607 name: linezolid namespace: chebi_ontology alt_id: CHEBI:6477 def: "An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex." [] subset: 3_STAR synonym: "Linezolid" EXACT [KEGG_COMPOUND] synonym: "linezolid" RELATED INN [KEGG_DRUG] synonym: "N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide" RELATED [ChemIDplus] synonym: "N-({(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide" EXACT IUPAC_NAME [IUPAC] xref: CAS:165800-03-3 {source="KEGG COMPOUND"} xref: CAS:165800-03-3 {source="ChemIDplus"} xref: Drug_Central:1584 {source="DrugCentral"} xref: DrugBank:DB00601 xref: KEGG:C08146 xref: KEGG:D00947 xref: LINCS:LSM-5750 xref: Patent:US5688792 xref: Patent:WO957271 xref: PDBeChem:ZLD xref: PMID:21740298 {source="Europe PMC"} xref: PMID:21815204 {source="Europe PMC"} xref: PMID:21899392 {source="Europe PMC"} xref: PMID:22037854 {source="Europe PMC"} xref: PMID:22064533 {source="Europe PMC"} xref: PMID:22064542 {source="Europe PMC"} xref: PMID:22110086 {source="Europe PMC"} xref: PMID:22134348 {source="Europe PMC"} xref: PMID:22139199 {source="Europe PMC"} xref: PMID:22214776 {source="Europe PMC"} xref: PMID:22230331 {source="Europe PMC"} xref: PMID:22247123 {source="Europe PMC"} xref: Reaxys:7496939 {source="Reaxys"} xref: Wikipedia:Linezolid is_a: CHEBI:22160 ! acetamides is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38785 ! morpholines is_a: CHEBI:55374 ! oxazolidinone relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H20FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TYZROVQLWOKYKF-ZDUSSCGKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "337.34610" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "337.14378" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCOCC2)c(F)c1" xsd:string [Term] id: CHEBI:63611 name: moxifloxacin namespace: chebi_ontology alt_id: CHEBI:7007 def: "A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents." [] subset: 3_STAR synonym: "1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Moxifloxacin" EXACT [KEGG_COMPOUND] synonym: "moxifloxacin" RELATED INN [ChemIDplus] xref: CAS:151096-09-2 {source="ChemIDplus"} xref: CAS:151096-09-2 {source="KEGG COMPOUND"} xref: Drug_Central:1854 {source="DrugCentral"} xref: DrugBank:DB00218 xref: KEGG:C07663 xref: KEGG:D08237 xref: LINCS:LSM-5746 xref: Patent:EP550903 xref: Reaxys:8365827 {source="Reaxys"} xref: VSDB:2983 xref: Wikipedia:Moxifloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51454 ! cyclopropanes is_a: CHEBI:63697 ! pyrrolidinopiperidine is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_conjugate_base_of CHEBI:63699 ! moxifloxacinium(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H24FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FABPRXSRWADJSP-MEDUHNTESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "401.43140" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "401.17508" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCN[C@]1([H])CN(C2)c1c(F)cc2c(c1OC)n(cc(C(O)=O)c2=O)C1CC1" xsd:string [Term] id: CHEBI:63673 name: chemokine receptor 5 antagonist namespace: chebi_ontology def: "An antogonist that blocks chemokine receptor 5 (CCR5)." [] subset: 3_STAR synonym: "C-C chemokine receptor 5 antagonist" RELATED [ChEBI] synonym: "C-C chemokine receptor 5 antagonists" RELATED [ChEBI] synonym: "CCR-5 antagonist" RELATED [ChEBI] synonym: "CCR-5 antagonists" RELATED [ChEBI] synonym: "CCR5 antagonist" RELATED [ChEBI] synonym: "CCR5 antagonists" RELATED [ChEBI] synonym: "chemokine receptor 5 antagonists" RELATED [ChEBI] xref: Wikipedia:CCR5 is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:63697 name: pyrrolidinopiperidine namespace: chebi_ontology def: "Any organic heterobicyclic compound containing ortho-fused pyrrolidine and piperidine rings." [] subset: 3_STAR is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:63699 name: moxifloxacinium(1+) namespace: chebi_ontology def: "An organic cation obtained by protonation of moxifloxacin." [] subset: 3_STAR synonym: "moxifloxacin cation" RELATED [ChEBI] synonym: "moxifloxacin(1+)" RELATED [ChEBI] synonym: "moxifloxacinium" RELATED [ChEBI] synonym: "moxifloxacinium cation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:63611 ! moxifloxacin property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H25FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/p+1/t11-,16+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FABPRXSRWADJSP-MEDUHNTESA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "402.43930" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "402.18236" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H+].[H][C@@]12CCCN[C@]1([H])CN(C2)c1c(F)cc2c(c1OC)n(cc(C(O)=O)c2=O)C1CC1" xsd:string [Term] id: CHEBI:63726 name: neuroprotective agent namespace: chebi_ontology def: "Any compound that can be used for the treatment of neurodegenerative disorders." [] subset: 3_STAR synonym: "neuroprotectant" RELATED [ChEBI] synonym: "neuroprotectants" RELATED [ChEBI] synonym: "neuroprotective agents" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:63944 name: macrocyclic lactone namespace: chebi_ontology alt_id: CHEBI:50333 def: "Any lactone in which the cyclic carboxylic ester group forms a part of a cyclic macromolecule." [] subset: 3_STAR synonym: "macrocyclic lactones" RELATED [ChEBI] is_a: CHEBI:25000 ! lactone is_a: CHEBI:51026 ! macrocycle [Term] id: CHEBI:63951 name: estrogen receptor agonist namespace: chebi_ontology def: "An agonist at the estrogen receptor." [] subset: 3_STAR synonym: "estrogen receptor agonists" RELATED [ChEBI] is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:64047 name: food additive namespace: chebi_ontology def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." [] subset: 3_STAR synonym: "food additives" RELATED [ChEBI] xref: Wikipedia:Food_additive is_a: CHEBI:33232 ! application is_a: CHEBI:78295 ! food component [Term] id: CHEBI:64049 name: food acidity regulator namespace: chebi_ontology def: "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." [] subset: 3_STAR synonym: "acidity regulator" RELATED [ChEBI] synonym: "acidity regulators" RELATED [ChEBI] synonym: "food acidity regulators" RELATED [ChEBI] synonym: "pH control agent" RELATED [ChEBI] synonym: "pH control agents" RELATED [ChEBI] xref: Wikipedia:Acidity_regulator is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:64130 name: pyrazinoindole namespace: chebi_ontology def: "An organic heterotricyclic compound comprising a pyrazine ring fused to an indole ring system." [] subset: 3_STAR synonym: "pyrazinoindoles" RELATED [ChEBI] is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:64133 name: EC 2.5.1.58 (protein farnesyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein farnesyltransferase (EC 2.5.1.58), one of the three enzymes in the prenyltransferase group." [] subset: 3_STAR synonym: "EC 2.5.1.58 (protein farnesyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.58 inhibitor" RELATED [ChEBI] synonym: "EC 2.5.1.58 inhibitors" RELATED [ChEBI] synonym: "farnesyl transferase inhibitor" RELATED [ChEBI] synonym: "farnesyl transferase inhibitors" RELATED [ChEBI] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitor" RELATED [ChEBI] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitors" RELATED [ChEBI] synonym: "farnesyltransferase inhibitor" RELATED [ChEBI] synonym: "farnesyltransferase inhibitors" RELATED [ChEBI] synonym: "FTase inhibitor" RELATED [ChEBI] synonym: "FTase inhibitors" RELATED [ChEBI] synonym: "protein farnesyltransferase (EC 2.5.1.58) inhibitor" RELATED [ChEBI] synonym: "protein farnesyltransferase (EC 2.5.1.58) inhibitors" RELATED [ChEBI] synonym: "protein farnesyltransferase inhibitor" RELATED [ChEBI] synonym: "protein farnesyltransferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Farnesyltransferase is_a: CHEBI:76663 ! EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor [Term] id: CHEBI:64228 name: tunicamycin A0 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by an 11-methyldodec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-11-methyldodec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(11-methyldodec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] synonym: "tunicamycin I" RELATED [ChEBI] xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C36H58N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C36H58N4O16/c1-17(2)11-9-7-5-4-6-8-10-12-22(44)38-25-29(49)26(46)20(53-35(25)56-34-24(37-18(3)42)28(48)27(47)21(16-41)54-34)15-19(43)32-30(50)31(51)33(55-32)40-14-13-23(45)39-36(40)52/h10,12-14,17,19-21,24-35,41,43,46-51H,4-9,11,15-16H2,1-3H3,(H,37,42)(H,38,44)(H,39,45,52)/b12-10+/t19-,20-,21-,24-,25-,26+,27-,28-,29-,30+,31-,32-,33-,34-,35+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FIIRBPHYBLFBSD-MZPZZZQLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "802.86290" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "802.38478" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCC(C)C)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64237 name: EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor namespace: chebi_ontology def: "An EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor that interferes with the action of any UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15), preventing formation of N-acetylglucosamine lipid intermediates and glycosylation of newly synthesised glycoproteins." [] subset: 3_STAR synonym: "chitobiosylpyrophosphoryldolichol synthase inhibitor" RELATED [ChEBI] synonym: "chitobiosylpyrophosphoryldolichol synthase inhibitors" RELATED [ChEBI] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.8.15 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.8.15 inhibitors" RELATED [ChEBI] synonym: "GlcNAc-1-P transferase inhibitor" RELATED [ChEBI] synonym: "GlcNAc-1-P transferase inhibitors" RELATED [ChEBI] synonym: "N-acetylglucosamine phosphotransferase inhibitor" RELATED [ChEBI] synonym: "N-acetylglucosamine transferase inhibitors" RELATED [ChEBI] synonym: "N-acetylglucosamine-1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "N-acetylglucosamine-1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitors" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitors" RELATED [ChEBI] synonym: "uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76816 ! EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor [Term] id: CHEBI:64245 name: tunicamycin A1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 12-methyltridec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-12-methyltridec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(12-methyltridec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] synonym: "tunicamycin A1" EXACT [UniProt] synonym: "tunicamycin C" RELATED [ChEBI] synonym: "tunicamycin II" RELATED [ChEBI] xref: PMID:7061468 {source="Europe PMC"} xref: Reaxys:8183793 {source="Reaxys"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C37H60N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C37H60N4O16/c1-18(2)12-10-8-6-4-5-7-9-11-13-23(45)39-26-30(50)27(47)21(54-36(26)57-35-25(38-19(3)43)29(49)28(48)22(17-42)55-35)16-20(44)33-31(51)32(52)34(56-33)41-15-14-24(46)40-37(41)53/h11,13-15,18,20-22,25-36,42,44,47-52H,4-10,12,16-17H2,1-3H3,(H,38,43)(H,39,45)(H,40,46,53)/b13-11+/t20-,21-,22-,25-,26-,27+,28-,29-,30-,31+,32-,33-,34-,35-,36+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YJQCOFNZVFGCAF-LLXUUZRASA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "816.88950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "816.40043" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCC(C)C)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64246 name: tunicamycin A2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a tetradec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]tetradec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(tetradec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] synonym: "tunicamycin III" RELATED [ChEBI] xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C37H60N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C37H60N4O16/c1-3-4-5-6-7-8-9-10-11-12-13-14-23(45)39-26-30(50)27(47)21(54-36(26)57-35-25(38-19(2)43)29(49)28(48)22(18-42)55-35)17-20(44)33-31(51)32(52)34(56-33)41-16-15-24(46)40-37(41)53/h13-16,20-22,25-36,42,44,47-52H,3-12,17-18H2,1-2H3,(H,38,43)(H,39,45)(H,40,46,53)/b14-13+/t20-,21-,22-,25-,26-,27+,28-,29-,30-,31+,32-,33-,34-,35-,36+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MMDMXWRRAOLMDC-ZNZAGFTISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "816.88950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "816.40043" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCCCC)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64248 name: tunicamycin B1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a pentadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]pentadec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(pentadec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] synonym: "tunicamycin IV" RELATED [ChEBI] xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C38H62N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C38H62N4O16/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(2)44)30(50)29(49)23(19-43)56-36)18-21(45)34-32(52)33(53)35(57-34)42-17-16-25(47)41-38(42)54/h14-17,21-23,26-37,43,45,48-53H,3-13,18-19H2,1-2H3,(H,39,44)(H,40,46)(H,41,47,54)/b15-14+/t21-,22-,23-,26-,27-,28+,29-,30-,31-,32+,33-,34-,35-,36-,37+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QYVMTFXNKNWWFX-YGTZKZKGSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "830.91610" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "830.41608" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCCCCC)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64250 name: tunicamycin B2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 13-methyltetradec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-13-methyltetradec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(13-methyltetradec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] synonym: "tunicamycin A" RELATED [ChEBI] synonym: "tunicamycin V" RELATED [ChEBI] xref: PMID:7061468 {source="Europe PMC"} xref: Reaxys:5711197 {source="Reaxys"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C38H62N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C38H62N4O16/c1-19(2)13-11-9-7-5-4-6-8-10-12-14-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(3)44)30(50)29(49)23(18-43)56-36)17-21(45)34-32(52)33(53)35(57-34)42-16-15-25(47)41-38(42)54/h12,14-16,19,21-23,26-37,43,45,48-53H,4-11,13,17-18H2,1-3H3,(H,39,44)(H,40,46)(H,41,47,54)/b14-12+/t21-,22-,23-,26-,27-,28+,29-,30-,31-,32+,33-,34-,35-,36-,37+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MEYZYGMYMLNUHJ-DIRMKAHISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "830.91610" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "830.41608" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCCC(C)C)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64255 name: tunicamycin B3 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by an 13-methyltetradecanoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-13-methyltetradecanamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(13-methyltetradecanamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] synonym: "tunicamycin VI" RELATED [ChEBI] xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C38H64N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C38H64N4O16/c1-19(2)13-11-9-7-5-4-6-8-10-12-14-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(3)44)30(50)29(49)23(18-43)56-36)17-21(45)34-32(52)33(53)35(57-34)42-16-15-25(47)41-38(42)54/h15-16,19,21-23,26-37,43,45,48-53H,4-14,17-18H2,1-3H3,(H,39,44)(H,40,46)(H,41,47,54)/t21-,22-,23-,26-,27-,28+,29-,30-,31-,32+,33-,34-,35-,36-,37+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XAFNQFHOQPRGAK-KTVOANSYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "832.93200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "832.43173" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)CCCCCCCCCCCC(C)C)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64256 name: tunicamycin C1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 14-methylpentadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-14-methylpentadec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(14-methylpentadec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] synonym: "corynetoxin U-16I" RELATED [ChemIDplus] synonym: "tunicamycin B" RELATED [ChEBI] synonym: "tunicamycin VII" RELATED [ChEBI] xref: CAS:66081-36-5 {source="ChemIDplus"} xref: Chemspider:27471426 xref: MetaCyc:CPD-19373 xref: PMID:29844049 {source="Europe PMC"} xref: PMID:29973921 {source="Europe PMC"} xref: PMID:30445836 {source="Europe PMC"} xref: PMID:33636028 {source="Europe PMC"} xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:76507 ! has role marine metabolite relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C39H64N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C39H64N4O16/c1-20(2)14-12-10-8-6-4-5-7-9-11-13-15-25(47)41-28-32(52)29(49)23(56-38(28)59-37-27(40-21(3)45)31(51)30(50)24(19-44)57-37)18-22(46)35-33(53)34(54)36(58-35)43-17-16-26(48)42-39(43)55/h13,15-17,20,22-24,27-38,44,46,49-54H,4-12,14,18-19H2,1-3H3,(H,40,45)(H,41,47)(H,42,48,55)/b15-13+/t22-,23-,24-,27-,28-,29+,30-,31-,32-,33+,34-,35-,36-,37-,38+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZOCXUHJGZXXIGQ-NPXWYGMKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "844.94270" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "844.43173" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCCCC(C)C)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64257 name: tunicamycin C2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a hexadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]hexadec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(hexadec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C39H64N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C39H64N4O16/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-25(47)41-28-32(52)29(49)23(56-38(28)59-37-27(40-21(2)45)31(51)30(50)24(20-44)57-37)19-22(46)35-33(53)34(54)36(58-35)43-18-17-26(48)42-39(43)55/h15-18,22-24,27-38,44,46,49-54H,3-14,19-20H2,1-2H3,(H,40,45)(H,41,47)(H,42,48,55)/b16-15+/t22-,23-,24-,27-,28-,29+,30-,31-,32-,33+,34-,35-,36-,37-,38+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NKDRZEIENXWUCE-VDIUWDQWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "844.94270" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "844.43173" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCCCCCC)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64268 name: erythromycin A(1+) namespace: chebi_ontology def: "An erythromycin cation that is the conjugate acid of erythromycin A, arising from protonation of the tertiary amino group on the 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residue; major species at pH 7.3." [] subset: 3_STAR synonym: "erythromycin A" RELATED [UniProt] synonym: "erythromycin A cation" RELATED [ChEBI] xref: MetaCyc:CPD-13804 {source="SUBMITTER"} is_a: CHEBI:64290 ! erythromycin cation relationship: is_conjugate_acid_of CHEBI:42355 ! erythromycin A relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C37H68NO13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/p+1/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ULGZDMOVFRHVEP-RWJQBGPGSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "734.93470" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "734.46852" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)[NH+](C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O" xsd:string [Term] id: CHEBI:64271 name: tunicamycin D1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a heptadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]heptadec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(heptadec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C40H66N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C40H66N4O16/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-26(48)42-29-33(53)30(50)24(57-39(29)60-38-28(41-22(2)46)32(52)31(51)25(21-45)58-38)20-23(47)36-34(54)35(55)37(59-36)44-19-18-27(49)43-40(44)56/h16-19,23-25,28-39,45,47,50-55H,3-15,20-21H2,1-2H3,(H,41,46)(H,42,48)(H,43,49,56)/b17-16+/t23-,24-,25-,28-,29-,30+,31-,32-,33-,34+,35-,36-,37-,38-,39+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYGXSHBNTGWENQ-YTXMDVFISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "858.96920" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "858.44738" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCCCCCCC)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64272 name: tunicamycin D2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 15-methylhexadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "(2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-15-methylhexadec-2-enamide" EXACT IUPAC_NAME [IUPAC] synonym: "(5'R)-5'-[2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1<->1)-2,6-dideoxy-2-(15-methylhexadec-2-enamido)-beta-D-galactopyranos-6-yl]uridine" EXACT IUPAC_NAME [IUPAC] xref: PMID:7061468 {source="Europe PMC"} is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C40H66N4O16" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C40H66N4O16/c1-21(2)15-13-11-9-7-5-4-6-8-10-12-14-16-26(48)42-29-33(53)30(50)24(57-39(29)60-38-28(41-22(3)46)32(52)31(51)25(20-45)58-38)19-23(47)36-34(54)35(55)37(59-36)44-18-17-27(49)43-40(44)56/h14,16-18,21,23-25,28-39,45,47,50-55H,4-13,15,19-20H2,1-3H3,(H,41,46)(H,42,48)(H,43,49,56)/b16-14+/t23-,24-,25-,28-,29-,30+,31-,32-,33-,34+,35-,36-,37-,38-,39+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XCEPHNBEHQJSSB-LGJGITPNSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "858.96920" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "858.44738" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@](O)(C[C@H]1O[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC(=O)\\C=C\\CCCCCCCCCCCC(C)C)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" xsd:string [Term] id: CHEBI:64290 name: erythromycin cation namespace: chebi_ontology def: "An organic cation obtained by protonation of any erythromycin." [] subset: 3_STAR synonym: "erythromycin cation" EXACT [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_base_of CHEBI:48923 ! erythromycin [Term] id: CHEBI:64355 name: posaconazole namespace: chebi_ontology def: "An N-arylpiperazine that consists of piperazine carrying two 4-substituted phenyl groups at positions 1 and 4. A triazole antifungal drug." [] subset: 3_STAR synonym: "2,5-anhydro-1,3,4-trideoxy-2-(2,4-difluorophenyl)-4-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol" EXACT IUPAC_NAME [IUPAC] synonym: "Noxafil" RELATED BRAND_NAME [DrugBank] synonym: "posaconazole" EXACT [UniProt] synonym: "posaconazole" RELATED INN [KEGG_DRUG] synonym: "Sch 56592" RELATED [ChemIDplus] synonym: "SCH56592" RELATED [ChEBI] synonym: "Schering 56592" RELATED [ChEBI] xref: CAS:171228-49-2 {source="KEGG DRUG"} xref: CAS:171228-49-2 {source="ChemIDplus"} xref: Drug_Central:3483 {source="DrugCentral"} xref: DrugBank:DB01263 xref: KEGG:D02555 xref: Patent:US5661151 xref: Patent:WO9517407 xref: PMID:21762211 {source="Europe PMC"} xref: PMID:21967490 {source="Europe PMC"} xref: PMID:22058198 {source="Europe PMC"} xref: PMID:22176629 {source="Europe PMC"} xref: PMID:22215361 {source="Europe PMC"} xref: PMID:22215487 {source="Europe PMC"} xref: PMID:22286158 {source="Europe PMC"} xref: PMID:22290952 {source="Europe PMC"} xref: PMID:22303909 {source="Europe PMC"} xref: PMID:22324990 {source="Europe PMC"} xref: PMID:22330929 {source="Europe PMC"} xref: PMID:22380765 {source="Europe PMC"} xref: PMID:22391464 {source="Europe PMC"} xref: PMID:22391534 {source="Europe PMC"} xref: PMID:22427614 {source="Europe PMC"} xref: Reaxys:8379448 {source="Reaxys"} xref: Wikipedia:Posaconazole is_a: CHEBI:26912 ! oxolanes is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C37H42F2N8O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RAGOYPUPXAKGKH-XAKZXMRKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "700.77740" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "700.32971" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OC[C@@H]3CO[C@](Cn4cncn4)(C3)c3ccc(F)cc3F)cc2)c1=O" xsd:string [Term] id: CHEBI:64383 name: pentamidinium(2+) namespace: chebi_ontology def: "A carboxamidinium ion obtained by protonation of both amindino groups of pentamidine." [] subset: 3_STAR synonym: "[pentane-1,5-diylbis(oxy-4,1-phenylene)]bis(aminomethaniminium)" EXACT IUPAC_NAME [IUPAC] synonym: "pentamidine dication" RELATED [ChEBI] synonym: "pentamidine(2+)" RELATED [ChEBI] synonym: "pentamidinium cation" RELATED [ChEBI] synonym: "pentamidinium dication" RELATED [ChEBI] is_a: CHEBI:77718 ! carboxamidinium ion relationship: is_conjugate_acid_of CHEBI:45081 ! pentamidine property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H26N4O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)/p+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XDRYMKDFEDOLFX-UHFFFAOYSA-P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "342.43420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "342.20448" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=[NH2+])c1ccc(OCCCCCOc2ccc(cc2)C(N)=[NH2+])cc1" xsd:string [Term] id: CHEBI:64459 name: biaryl namespace: chebi_ontology def: "An organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond." [] subset: 3_STAR synonym: "biaryls" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:64571 name: NMDA receptor agonist namespace: chebi_ontology def: "An excitatory amino acid agonist which binds to NMDA receptors and triggers a response." [] subset: 3_STAR synonym: "N-methyl-D-aspartate receptor agonist" RELATED [ChEBI] synonym: "N-methyl-D-aspartate receptor agonists" RELATED [ChEBI] synonym: "NMDA receptor agonists" RELATED [ChEBI] synonym: "NMDAR agonist" RELATED [ChEBI] synonym: "NMDAR agonists" RELATED [ChEBI] is_a: CHEBI:50103 ! excitatory amino acid agonist [Term] id: CHEBI:64577 name: flour treatment agent namespace: chebi_ontology def: "A food additive which is added to flour or dough to improve baking quality and/or colour." [] subset: 3_STAR synonym: "dough improver" RELATED [ChEBI] synonym: "dough improvers" RELATED [ChEBI] synonym: "flour treatment agent" EXACT [ChEBI] synonym: "improving agent" RELATED [ChEBI] synonym: "improving agents" RELATED [ChEBI] xref: Wikipedia:Flour_treatment_agent is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:64641 name: divalent inorganic cation namespace: chebi_ontology def: "An inorganic cation with a valency of two." [] subset: 3_STAR is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:64708 name: one-carbon compound namespace: chebi_ontology def: "An organic molecular entity containing a single carbon atom (C1)." [] subset: 3_STAR synonym: "one-carbon compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:64709 name: organic acid namespace: chebi_ontology def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." [] subset: 3_STAR synonym: "organic acids" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:6472 name: lincomycin namespace: chebi_ontology def: "A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis." [] subset: 3_STAR synonym: "Cillimycin" RELATED [ChemIDplus] synonym: "lincomicina" RELATED INN [ChemIDplus] synonym: "Lincomycin" EXACT [KEGG_COMPOUND] synonym: "lincomycin" RELATED INN [WHO_MedNet] synonym: "lincomycine" RELATED INN [ChemIDplus] synonym: "lincomycinum" RELATED INN [ChemIDplus] synonym: "methyl 6,8-dideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-erythro-alpha-D-galacto-octopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside" RELATED [NIST_Chemistry_WebBook] xref: CAS:154-21-2 {source="KEGG COMPOUND"} xref: CAS:154-21-2 {source="ChemIDplus"} xref: Drug_Central:1582 {source="DrugCentral"} xref: DrugBank:DB01627 xref: HMDB:HMDB0015564 xref: KEGG:C06812 xref: KEGG:C14002 xref: KEGG:D00223 xref: KEGG:D02346 xref: LINCS:LSM-5602 xref: PMID:24324587 {source="Europe PMC"} xref: Reaxys:707677 {source="Reaxys"} xref: Wikipedia:Lincomycin is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:35275 ! S-glycosyl compound is_a: CHEBI:46770 ! pyrrolidinecarboxamide is_a: CHEBI:84186 ! L-proline derivative relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H34N2O6S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OJMMVQQUTAEWLP-KIDUDLJLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "406.53700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "406.21376" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O" xsd:string [Term] id: CHEBI:64909 name: poison namespace: chebi_ontology def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." [] subset: 3_STAR synonym: "poisonous agent" RELATED [ChEBI] synonym: "poisonous agents" RELATED [ChEBI] synonym: "poisonous substance" RELATED [ChEBI] synonym: "poisonous substances" RELATED [ChEBI] synonym: "poisons" RELATED [ChEBI] synonym: "toxic agent" RELATED [ChEBI] synonym: "toxic agents" RELATED [ChEBI] synonym: "toxic substance" RELATED [ChEBI] synonym: "toxic substances" RELATED [ChEBI] xref: Wikipedia:Poison is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:64911 name: antimitotic namespace: chebi_ontology def: "Any compound that inhibits cell division (mitosis)." [] subset: 3_STAR synonym: "antimitotics" RELATED [ChEBI] synonym: "mitosis inhibitor" RELATED [ChEBI] synonym: "mitosis inhibitors" RELATED [ChEBI] synonym: "mitotic inhibitor" RELATED [ChEBI] synonym: "mitotic inhibitors" RELATED [ChEBI] xref: Wikipedia:Mitotic_inhibitor is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:64912 name: antimycobacterial drug namespace: chebi_ontology def: "A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy." [] subset: 3_STAR synonym: "antimycobacterial agent" RELATED [ChEBI] synonym: "antimycobacterial agents" RELATED [ChEBI] synonym: "antimycobacterial drugs" RELATED [ChEBI] synonym: "antimycobacterials" RELATED [ChEBI] synonym: "antimycobacterium" RELATED [ChEBI] is_a: CHEBI:36047 ! antibacterial drug [Term] id: CHEBI:64915 name: antiplasmodial drug namespace: chebi_ontology def: "An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria." [] subset: 3_STAR synonym: "antiplasmodial agent" RELATED [ChEBI] synonym: "antiplasmodial agents" RELATED [ChEBI] synonym: "antiplasmodial drugs" RELATED [ChEBI] synonym: "antiplasmodium agent" RELATED [ChEBI] synonym: "antiplasmodium agents" RELATED [ChEBI] synonym: "antiplasmodium drug" RELATED [ChEBI] synonym: "antiplasmodium drugs" RELATED [ChEBI] is_a: CHEBI:35820 ! antiprotozoal drug [Term] id: CHEBI:64933 name: melanin synthesis inhibitor namespace: chebi_ontology def: "A depigmentation agent which inhibits the synthesis of melanin." [] subset: 3_STAR synonym: "melanin biosynthesis inhibitor" RELATED [ChEBI] synonym: "melanin biosynthesis inhibitors" RELATED [ChEBI] synonym: "melanin synthesis inhibitors" RELATED [ChEBI] synonym: "melanogenesis inhibitor" RELATED [ChEBI] synonym: "melanogenesis inhibitors" RELATED [ChEBI] is_a: CHEBI:59864 ! depigmentation drug [Term] id: CHEBI:64946 name: anti-HIV agent namespace: chebi_ontology def: "An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus." [] subset: 3_STAR synonym: "anti-AIDS agent" RELATED [ChEBI] synonym: "anti-AIDS agents" RELATED [ChEBI] synonym: "anti-HIV agents" RELATED [ChEBI] is_a: CHEBI:22587 ! antiviral agent [Term] id: CHEBI:64996 name: EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor namespace: chebi_ontology def: "A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33)." [] subset: 3_STAR synonym: "15-lipoxygenase inhibitor" RELATED [ChEBI] synonym: "15-lipoxygenase inhibitors" RELATED [ChEBI] synonym: "15-LOX inhibitor" RELATED [ChEBI] synonym: "15-LOX inhibitors" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitor" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitors" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase inhibitor" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase inhibitors" RELATED [ChEBI] synonym: "arachidonate:oxygen 15-oxidoreductase inhibitor" RELATED [ChEBI] synonym: "arachidonate:oxygen 15-oxidoreductase inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.33 inhibitor" RELATED [ChEBI] synonym: "EC 1.13.11.33 inhibitors" RELATED [ChEBI] synonym: "linoleic acid omega(6)-lipoxygenase inhibitor" RELATED [ChEBI] synonym: "linoleic acid omega(6)-lipoxygenase inhibitors" RELATED [ChEBI] synonym: "omega(6) lipoxygenase inhibitor" RELATED [ChEBI] synonym: "omega(6) lipoxygenase inhibitors" RELATED [ChEBI] xref: Wikipedia:ALOX15 is_a: CHEBI:35856 ! lipoxygenase inhibitor [Term] id: CHEBI:65001 name: EC 3.1.1.3 (triacylglycerol lipase) inhibitor namespace: chebi_ontology def: "Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3)." [] subset: 3_STAR synonym: "butyrinase inhibitor" RELATED [ChEBI] synonym: "butyrinase inhibitors" RELATED [ChEBI] synonym: "cacordase inhibitor" RELATED [ChEBI] synonym: "cacordase inhibitors" RELATED [ChEBI] synonym: "capalase L inhibitor" RELATED [ChEBI] synonym: "capalase L inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.3 (triacylglycerol lipase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.3 inhibitor" RELATED [ChEBI] synonym: "EC 3.1.1.3 inhibitors" RELATED [ChEBI] synonym: "GEH inhibitor" RELATED [ChEBI] synonym: "GEH inhibitors" RELATED [ChEBI] synonym: "glycerol ester hydrolase inhibitor" RELATED [ChEBI] synonym: "glycerol ester hydrolase inhibitors" RELATED [ChEBI] synonym: "glycerol-ester hydrolase inhibitor" RELATED [ChEBI] synonym: "glycerol-ester hydrolase inhibitors" RELATED [ChEBI] synonym: "heparin releasable hepatic lipase inhibitor" RELATED [ChEBI] synonym: "heparin releasable hepatic lipase inhibitors" RELATED [ChEBI] synonym: "hepatic lipase inhibitor" RELATED [ChEBI] synonym: "hepatic lipase inhibitors" RELATED [ChEBI] synonym: "hepatic monoacylglycerol acyltransferase inhibitor" RELATED [ChEBI] synonym: "hepatic monoacylglycerol acyltransferase inhibitors" RELATED [ChEBI] synonym: "lipase inhibitor" RELATED [ChEBI] synonym: "lipase inhibitors" RELATED [ChEBI] synonym: "lipazin inhibitor" RELATED [ChEBI] synonym: "lipazin inhibitors" RELATED [ChEBI] synonym: "liver lipase inhibitor" RELATED [ChEBI] synonym: "liver lipase inhibitors" RELATED [ChEBI] synonym: "pancreatic lipase inhibitor" RELATED [ChEBI] synonym: "pancreatic lipase inhibitors" RELATED [ChEBI] synonym: "pancreatic triacylglycerol lipase inhibitor" RELATED [ChEBI] synonym: "pancreatic triacylglycerol lipase inhibitors" RELATED [ChEBI] synonym: "post-heparin plasma protamine-resistant lipase inhibitor" RELATED [ChEBI] synonym: "post-heparin plasma protamine-resistant lipase inhibitors" RELATED [ChEBI] synonym: "PPL inhibitor" RELATED [ChEBI] synonym: "PPL inhibitors" RELATED [ChEBI] synonym: "salt-resistant post-heparin lipase inhibitor" RELATED [ChEBI] synonym: "salt-resistant post-heparin lipase inhibitors" RELATED [ChEBI] synonym: "steapsin inhibitor" RELATED [ChEBI] synonym: "steapsin inhibitors" RELATED [ChEBI] synonym: "triacetinase inhibitor" RELATED [ChEBI] synonym: "triacetinase inhibitors" RELATED [ChEBI] synonym: "triacylglycerol ester hydrolase inhibitor" RELATED [ChEBI] synonym: "triacylglycerol ester hydrolase inhibitors" RELATED [ChEBI] synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitor" RELATED [ChEBI] synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitors" RELATED [ChEBI] synonym: "triacylglycerol lipase inhibitor" RELATED [ChEBI] synonym: "triacylglycerol lipase inhibitors" RELATED [ChEBI] synonym: "tributyrase inhibitor" RELATED [ChEBI] synonym: "tributyrase inhibitors" RELATED [ChEBI] synonym: "tributyrin esterase inhibitor" RELATED [ChEBI] synonym: "tributyrin esterase inhibitors" RELATED [ChEBI] synonym: "tributyrinase inhibitor" RELATED [ChEBI] synonym: "tributyrinase inhibitors" RELATED [ChEBI] synonym: "triglyceridase inhibitor" RELATED [ChEBI] synonym: "triglyceridase inhibitors" RELATED [ChEBI] synonym: "triglyceride hydrolase inhibitor" RELATED [ChEBI] synonym: "triglyceride hydrolase inhibitors" RELATED [ChEBI] synonym: "triglyceride lipase inhibitor" RELATED [ChEBI] synonym: "triglyceride lipase inhibitors" RELATED [ChEBI] synonym: "triolein hydrolase inhibitor" RELATED [ChEBI] synonym: "triolein hydrolase inhibitors" RELATED [ChEBI] synonym: "Tween hydrolase inhibitor" RELATED [ChEBI] synonym: "Tween hydrolase inhibitors" RELATED [ChEBI] synonym: "tween-hydrolysing esterase inhibitor" RELATED [ChEBI] synonym: "tween-hydrolyzing esterase inhibitors" RELATED [ChEBI] synonym: "Tweenase inhibitor" RELATED [ChEBI] synonym: "Tweenase inhibitors" RELATED [ChEBI] synonym: "Tweenesterase inhibitor" RELATED [ChEBI] synonym: "Tweenesterase inhibitors" RELATED [ChEBI] is_a: CHEBI:76773 ! EC 3.1.1.* (carboxylic ester hydrolase) inhibitor [Term] id: CHEBI:65023 name: anti-asthmatic agent namespace: chebi_ontology def: "Any compound that has anti-asthmatic effects." [] subset: 3_STAR synonym: "anti-asthmatic agents" RELATED [ChEBI] synonym: "antiasthmatic agent" RELATED [ChEBI] synonym: "antiasthmatic agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:65076 name: neamine(4+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the four free amino groups of neamine; major species at pH 7.3." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-diazaniumyl-2,3-dihydroxycyclohexyl 2,6-diazaniumyl-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "neamine" RELATED [UniProt] synonym: "neaminium tetracation" RELATED [ChEBI] synonym: "neaminium(4+)" RELATED [ChEBI] xref: PMID:17206729 {source="SUBMITTER"} is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:7489 ! neamine property_value: http://purl.obolibrary.org/obo/chebi/charge "+4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H30N4O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/p+4/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SYJXFKPQNSDJLI-HKEUSBCWSA-R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "326.38980" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "326.21434" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C[C@H]1O[C@H](O[C@@H]2[C@@H]([NH3+])C[C@@H]([NH3+])[C@H](O)[C@H]2O)[C@H]([NH3+])[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:65077 name: neomycin C(6+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the six free amino groups of neomycin C; major species at pH 7.3." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-diammmonio-2-{[3-O-(2,6-diammmonio-2,6-dideoxy-alpha-D-glucopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diammmonio-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "neomycin C" RELATED [UniProt] xref: PMID:17206729 {source="SUBMITTER"} is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:53634 ! neomycin C property_value: http://purl.obolibrary.org/obo/chebi/charge "+6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H52N6O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/p+6/t5-,6+,7-,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PGBHMTALBVVCIT-VZXHOKRSSA-T" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "620.692" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "620.35594" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H]1([C@H]([C@@H]([C@@H]([NH3+])[C@@H](O[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)O[C@H]3[C@@H]([C@H](C[C@H]([C@@H]3O)[NH3+])[NH3+])O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C[NH3+])O)O)[NH3+])O1)O)O)C[NH3+]" xsd:string [Term] id: CHEBI:65212 name: polysaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is any derivative of a polysaccharide." [] subset: 3_STAR synonym: "polysaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:18154 ! polysaccharide [Term] id: CHEBI:65255 name: food preservative namespace: chebi_ontology def: "Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes." [] subset: 3_STAR synonym: "food preservatives" RELATED [ChEBI] is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:65256 name: antimicrobial food preservative namespace: chebi_ontology def: "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." [] subset: 3_STAR synonym: "antimicrobial food preservatives" RELATED [ChEBI] synonym: "antimicrobial preservative" RELATED [ChEBI] synonym: "antimicrobial preservatives" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent is_a: CHEBI:65255 ! food preservative [Term] id: CHEBI:65259 name: GABA antagonist namespace: chebi_ontology def: "A compound that inhibits the action of gamma-aminobutyric acid." [] subset: 3_STAR synonym: "GABA antagonists" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor antagonist" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor antagonists" RELATED [ChEBI] xref: Wikipedia:GABA_antagonist is_a: CHEBI:48706 ! antagonist is_a: CHEBI:51374 ! GABA agent [Term] id: CHEBI:65296 name: primary ammonium ion namespace: chebi_ontology def: "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." [] subset: 3_STAR synonym: "a primary amine" RELATED [UniProt] synonym: "substituted ammonium" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:50994 ! primary amino compound property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "H3NR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "17.031" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.02655" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][*]" xsd:string [Term] id: CHEBI:67079 name: anti-inflammatory agent namespace: chebi_ontology def: "Any compound that has anti-inflammatory effects." [] subset: 3_STAR synonym: "anti-inflammatory agents" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:6827 name: methicillin namespace: chebi_ontology def: "A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6beta-(2,6-dimethoxybenzamido)-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "6beta-(2,6-dimethoxybenzamido)penicillanic acid" RELATED [ChEBI] synonym: "Methicillin" EXACT [KEGG_COMPOUND] synonym: "meticilina" RELATED INN [ChemIDplus] synonym: "meticillin" RELATED INN [ChemIDplus] synonym: "meticilline" RELATED INN [ChemIDplus] synonym: "meticillinum" RELATED INN [ChemIDplus] xref: Beilstein:966227 {source="Beilstein"} xref: CAS:61-32-5 {source="ChemIDplus"} xref: CAS:61-32-5 {source="KEGG COMPOUND"} xref: Drug_Central:1744 {source="DrugCentral"} xref: DrugBank:DB01603 xref: KEGG:C07177 xref: PMID:11969119 {source="Europe PMC"} xref: PMID:12569987 {source="Europe PMC"} xref: PMID:24405901 {source="Europe PMC"} xref: PMID:24433925 {source="Europe PMC"} xref: PMID:26962156 {source="Europe PMC"} xref: Reaxys:966227 {source="Reaxys"} xref: Wikipedia:Meticillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:52064 ! methicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H20N2O6S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H20N2O6S/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23)/t11-,12+,15-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RJQXTJLFIWVMTO-TYNCELHUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "380.41500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "380.10421" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(OC)cccc1OC)C(O)=O" xsd:string [Term] id: CHEBI:68452 name: azole namespace: chebi_ontology def: "Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen." [] subset: 3_STAR synonym: "azoles" RELATED [ChEBI] xref: Wikipedia:Azole is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38179 ! monocyclic heteroarene [Term] id: CHEBI:68481 name: mTOR inhibitor namespace: chebi_ontology def: "A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer." [] subset: 3_STAR synonym: "mammalian target of rapamycin inhibitor" RELATED [ChEBI] synonym: "mammalian target of rapamycin inhibitors" RELATED [ChEBI] synonym: "mTOR inhibitors" RELATED [ChEBI] xref: Wikipedia:MTOR_inhibitors is_a: CHEBI:37699 ! protein kinase inhibitor [Term] id: CHEBI:68495 name: apoptosis inducer namespace: chebi_ontology def: "Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms." [] subset: 3_STAR synonym: "apoptosis inducers" RELATED [ChEBI] synonym: "Type I cell-death inducer" RELATED [ChEBI] synonym: "Type I cell-death inducers" RELATED [ChEBI] synonym: "Type I programmed cell-death inducer" RELATED [ChEBI] synonym: "Type I programmed cell-death inducers" RELATED [ChEBI] is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:69136 name: latrunculin A namespace: chebi_ontology alt_id: CHEBI:43626 def: "A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes." [] subset: 3_STAR synonym: "(+)-latrunculin A" RELATED [ChEBI] synonym: "(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one" EXACT IUPAC_NAME [IUPAC] synonym: "(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one" RELATED [PDBeChem] synonym: "LAT-A" RELATED [ChemIDplus] synonym: "LatA" RELATED [ChEBI] synonym: "LATRUNCULIN A" EXACT [PDBeChem] synonym: "NSC 613011" RELATED [ChemIDplus] xref: CAS:76343-93-6 {source="ChemIDplus"} xref: PDBeChem:LAR xref: PMID:10859320 {source="Europe PMC"} xref: PMID:12087066 {source="Europe PMC"} xref: PMID:17897856 {source="Europe PMC"} xref: PMID:19528469 {source="Europe PMC"} xref: PMID:20677927 {source="Europe PMC"} xref: PMID:22492972 {source="Europe PMC"} xref: PMID:22498812 {source="Europe PMC"} xref: PMID:3200109 {source="Europe PMC"} xref: PMID:3556584 {source="Europe PMC"} xref: PMID:9250716 {source="Europe PMC"} xref: Reaxys:4239363 {source="Reaxys"} is_a: CHEBI:25106 ! macrolide is_a: CHEBI:46733 ! oxabicycloalkane is_a: CHEBI:48891 ! thiazolidinone is_a: CHEBI:59780 ! cyclic hemiketal relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:70728 ! has role actin polymerisation inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H31NO5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DDVBPZROPPMBLW-IZGXTMSKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "421.55000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "421.19229" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\\C=C/C=C/CC\\C(C)=C/C(=O)O2)O1" xsd:string [Term] id: CHEBI:6923 name: miconazole namespace: chebi_ontology alt_id: CHEBI:108917 def: "A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes." [] subset: 3_STAR synonym: "(+-)-miconazole" RELATED [ChEBI] synonym: "(RS)-miconazole" RELATED [ChEBI] synonym: "1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole" RELATED [ChemIDplus] synonym: "1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole" RELATED [ChEMBL] synonym: "Daktarin IV" RELATED [ChemIDplus] synonym: "Miconazole" EXACT [KEGG_DRUG] synonym: "Monistat IV (TN)" RELATED [KEGG_DRUG] synonym: "rac-1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] synonym: "rac-miconazole" RELATED [ChEBI] xref: CAS:22916-47-8 {source="ChemIDplus"} xref: CAS:22916-47-8 {source="KEGG DRUG"} xref: DrugBank:DB01110 xref: KEGG:D00416 xref: PMID:11922774 {source="Europe PMC"} xref: PMID:15187422 {source="Europe PMC"} xref: PMID:15778703 {source="Europe PMC"} xref: PMID:16608920 {source="Europe PMC"} xref: PMID:24389479 {source="Europe PMC"} xref: PMID:24533891 {source="Europe PMC"} xref: PMID:24550099 {source="Europe PMC"} xref: PMID:24629000 {source="Europe PMC"} xref: PMID:24842191 {source="Europe PMC"} xref: PMID:24852893 {source="Europe PMC"} xref: PMID:24919490 {source="Europe PMC"} xref: PMID:25070654 {source="Europe PMC"} xref: PMID:25084742 {source="Europe PMC"} xref: PMID:25179092 {source="Europe PMC"} xref: PMID:8683405 {source="Europe PMC"} xref: Reaxys:965511 {source="Reaxys"} xref: Wikipedia:Miconazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87069 ! imidazole antifungal drug is_a: CHEBI:87071 ! conazole antifungal drug relationship: has_part CHEBI:82894 ! (R)-miconazole relationship: has_part CHEBI:82897 ! (S)-miconazole relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:82891 ! has role glucocorticoid receptor antagonist [Term] id: CHEBI:7025 name: mupirocin namespace: chebi_ontology alt_id: CHEBI:44038 def: "An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections." [] subset: 3_STAR synonym: "9-({(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-({(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl)tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoyl}oxy)nonanoic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Bactroban" RELATED BRAND_NAME [ChemIDplus] synonym: "Centany" RELATED BRAND_NAME [ChemIDplus] synonym: "mupirocin" RELATED INN [WHO_MedNet] synonym: "mupirocina" RELATED INN [WHO_MedNet] synonym: "mupirocine" RELATED INN [WHO_MedNet] synonym: "mupirocinum" RELATED INN [WHO_MedNet] synonym: "Pseudomonic acid A" RELATED [ChemIDplus] xref: CAS:12650-69-0 {source="KEGG COMPOUND"} xref: CAS:12650-69-0 {source="ChemIDplus"} xref: Drug_Central:1857 {source="DrugCentral"} xref: DrugBank:DB00410 xref: HMDB:HMDB0014554 xref: KEGG:D01076 xref: Patent:DE2227739 xref: Patent:US3977943 xref: Patent:US4071536 xref: PMID:22500807 {source="Europe PMC"} xref: PMID:23337107 {source="Europe PMC"} xref: PMID:23535880 {source="Europe PMC"} xref: PMID:23543635 {source="Europe PMC"} xref: PMID:24625190 {source="Europe PMC"} xref: PMID:3101012 {source="Europe PMC"} xref: Wikipedia:Mupirocin is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:27136 ! triol is_a: CHEBI:32955 ! epoxide is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:46942 ! oxanes is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester relationship: is_conjugate_acid_of CHEBI:145790 ! mupirocin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H44O9" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MINDHVHHQZYEEK-HBBNESRFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "500.62220" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "500.29853" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]1CO[C@@H](C\\C(C)=C\\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:70727 name: topoisomerase inhibitor namespace: chebi_ontology def: "An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA)." [] subset: 3_STAR synonym: "topoisomerase inhibitors" RELATED [ChEBI] xref: Wikipedia:Topoisomerase is_a: CHEBI:76830 ! EC 5.99.1.* (miscellaneous isomerase) inhibitor [Term] id: CHEBI:70728 name: actin polymerisation inhibitor namespace: chebi_ontology def: "Any substance that inhibits the polymerisation of the protein actin." [] subset: 3_STAR synonym: "actin polymerisation inhibitors" RELATED [ChEBI] synonym: "actin polymerization inhibitor" RELATED [ChEBI] synonym: "actin polymerization inhibitors" RELATED [ChEBI] synonym: "inhibitor of actin polymerization" RELATED [ChEBI] synonym: "inhibitors of actin polymerization" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor [Term] id: CHEBI:70977 name: alkane-alpha,omega-diammonium(2+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the amino groups of any alkane-alpha,omega-diamine; major species at pH 7.3." [] subset: 3_STAR synonym: "an alkane-alpha,omega-diamine" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:35411 ! alkane-alpha,omega-diamine property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(CH2)n.C2H10N2" xsd:string [Term] id: CHEBI:71181 name: Sir2 inhibitor namespace: chebi_ontology def: "An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir2." [] subset: 3_STAR synonym: "Sir2 inhibitors" RELATED [ChEBI] xref: Wikipedia:Sir2 is_a: CHEBI:61115 ! EC 3.5.1.98 (histone deacetylase) inhibitor [Term] id: CHEBI:71285 name: organophosphonate(2-) namespace: chebi_ontology def: "An organophosphonate oxoanion obtained by deprotonation of both phosphonate OH groups of any phosphonic acid." [] subset: 3_STAR synonym: "organic phosphonate" RELATED [UniProt] synonym: "organophosphonate" RELATED [ChEBI] synonym: "organophosphonate dianion" RELATED [ChEBI] is_a: CHEBI:59635 ! organophosphonate oxoanion property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O3PR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "78.972" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "78.95851" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]P([O-])([*])=O" xsd:string [Term] id: CHEBI:71300 name: EC 2.* (transferase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)" [] subset: 3_STAR synonym: "EC 2 inhibitor" RELATED [ChEBI] synonym: "EC 2 inhibitors" RELATED [ChEBI] synonym: "EC 2.* (transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.* inhibitor" RELATED [ChEBI] synonym: "EC 2.* inhibitors" RELATED [ChEBI] synonym: "transferase inhibitor" RELATED [ChEBI] synonym: "transferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Transferase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:71321 name: fusidate namespace: chebi_ontology def: "A steroid acid anion that is the conjugate base of fusidic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3." [] subset: 3_STAR synonym: "(2Z)-2-[(17Z)-16beta-acetoxy-3alpha,11alpha-dihydroxy-4alpha,8alpha,10,14beta-tetramethyl-5alpha,9beta,13alpha-gonan-17-ylidene]-6-methylhept-5-enoate" EXACT IUPAC_NAME [IUPAC] synonym: "fusidate" EXACT [UniProt] synonym: "fusidine" RELATED [MetaCyc] synonym: "ramycin" RELATED [MetaCyc] xref: MetaCyc:CPD0-1606 {source="SUBMITTER"} is_a: CHEBI:50160 ! steroid acid anion relationship: is_conjugate_base_of CHEBI:29013 ! fusidic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C31H47O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/p-1/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IECPWNUMDGFDKC-MZJAQBGESA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "515.70130" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "515.33781" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\\C([C@H](C[C@]34C)OC(C)=O)=C(/CCC=C(C)C)C([O-])=O)[C@@]1(C)CC[C@@H](O)[C@H]2C" xsd:string [Term] id: CHEBI:71337 name: minocycline(1-) namespace: chebi_ontology def: "An organic anion that is the conjugate base of minocycline, obtained by deprotonation of the two enolic hydroxy groups and protonation of the non-aromatic tertiary amino group." [] subset: 3_STAR synonym: "(1S,4aS,11aR,12aS)-3-carbamoyl-10-(dimethylamino)-1-(dimethylazaniumyl)-4a,7-dihydroxy-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracene-2,5-diolate" EXACT IUPAC_NAME [IUPAC] synonym: "minocycline anion" RELATED [ChEBI] xref: PMID:20212112 {source="SUBMITTER"} is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:50694 ! minocycline relationship: is_conjugate_base_of CHEBI:77906 ! minocycline zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H26N3O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/p-1/t9-,11-,17-,23-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYKFCLLONBREIL-KVUCHLLUSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "456.46840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "456.17762" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12Cc3c(ccc(O)c3C(=O)C1=C([O-])[C@]1(O)C(=O)C(C(N)=O)=C([O-])[C@@H]([NH+](C)C)[C@]1([H])C2)N(C)C" xsd:string [Term] id: CHEBI:71339 name: novobiocin(1-) namespace: chebi_ontology def: "An organic anion that is the conjugate base of novobiocin." [] subset: 3_STAR synonym: "novobiocin" RELATED [UniProt] synonym: "novobiocin anion" RELATED [ChEBI] xref: PMID:20212112 {source="SUBMITTER"} is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:28368 ! novobiocin property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C31H35N2O11" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/p-1/t23-,25+,26-,29-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YJQPYGGHQPGBLI-KGSXXDOSSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "611.61640" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "611.22463" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c([O-])c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C" xsd:string [Term] id: CHEBI:71365 name: rifampicin zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 5-hydroxy group to the tertiary amino group of rifampicin." [] subset: 3_STAR synonym: "(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-acetoxy-6,9,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-4-ium-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-5-olate" EXACT IUPAC_NAME [IUPAC] synonym: "rifampicin" RELATED [UniProt] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:28077 ! rifampicin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C43H58N4O12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JQXXHWHPUNPDRT-WLSIYKJHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "822.94020" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "822.40512" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C)c([O-])c4c(O)c(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\\C=N\\N1CC[NH+](C)CC1)c(O)c4c3C2=O" xsd:string [Term] id: CHEBI:71392 name: tetracycline(1-) namespace: chebi_ontology def: "An organic anion that is the conjugate base of tetracycline obtained by deprotonation of the two enolic hydroxy groups and protonation of the tertiary amino group." [] subset: 3_STAR synonym: "(1S,4aS,11S,11aS,12aS)-3-carbamoyl-1-(dimethylazaniumyl)-4a,7,11-trihydroxy-11-methyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracene-2,5-diolate" EXACT IUPAC_NAME [IUPAC] synonym: "tetracycline anion" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:27902 ! tetracycline relationship: is_conjugate_base_of CHEBI:77932 ! tetracycline zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H23N2O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/p-1/t9-,10-,15-,21+,22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OFVLGDICTFRJMM-WESIUVDSSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "443.42660" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "443.14599" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C([O-])[C@]1(O)C(=O)C(C(N)=O)=C([O-])[C@H]2[NH+](C)C" xsd:string [Term] id: CHEBI:71415 name: nitrofurantoin namespace: chebi_ontology alt_id: CHEBI:7591 def: "An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA." [] subset: 3_STAR synonym: "1-((5-Nitrofurfurylidene)amino)hydantoin" RELATED [ChemIDplus] synonym: "1-(5-Nitro-2-furfurylidenamino)hydantoin" RELATED [ChemIDplus] synonym: "1-(5-Nitro-2-furfurylideneamino)hydantoin" RELATED [ChemIDplus] synonym: "1-[(5-Nitrofurfurylidene)amino]hydantoin" RELATED [NIST_Chemistry_WebBook] synonym: "1-{[(5-nitro-2-furyl)methylene]amino}imidazolidine-2,4-dione" EXACT IUPAC_NAME [IUPAC] synonym: "5-Nitrofurantoin" RELATED [NIST_Chemistry_WebBook] synonym: "N-(5-Nitrofurfurylidene)-1-aminohydantoin" RELATED [ChemIDplus] synonym: "nitrofurantoin" RELATED INN [KEGG_DRUG] synonym: "nitrofurantoina" RELATED INN [ChemIDplus] synonym: "nitrofurantoine" RELATED INN [ChemIDplus] synonym: "nitrofurantoinum" RELATED INN [ChemIDplus] xref: CAS:67-20-9 {source="KEGG COMPOUND"} xref: CAS:67-20-9 {source="ChemIDplus"} xref: CAS:67-20-9 {source="NIST Chemistry WebBook"} xref: Drug_Central:1949 {source="DrugCentral"} xref: DrugBank:DB00698 xref: KEGG:C07268 xref: KEGG:D00439 xref: Patent:US2610181 xref: Patent:US2898335 xref: Patent:US2927110 xref: Patent:WO2006019844 xref: Patent:WO2008103673 xref: Patent:WO2010065110 xref: PMID:21567157 {source="Europe PMC"} xref: PMID:22240115 {source="Europe PMC"} xref: PMID:22252772 {source="Europe PMC"} xref: PMID:22252808 {source="Europe PMC"} xref: PMID:22285235 {source="Europe PMC"} xref: PMID:22332195 {source="Europe PMC"} xref: PMID:22508296 {source="Europe PMC"} xref: PMID:22535452 {source="Europe PMC"} xref: PMID:22552451 {source="Europe PMC"} xref: PMID:22722224 {source="Europe PMC"} xref: PMID:22779302 {source="Europe PMC"} xref: PMID:22787489 {source="Europe PMC"} xref: PMID:22836745 {source="Europe PMC"} xref: PMID:22857139 {source="Europe PMC"} xref: PMID:22869929 {source="Europe PMC"} xref: PMID:22876623 {source="Europe PMC"} xref: PMID:22923965 {source="Europe PMC"} xref: PMID:22929632 {source="Europe PMC"} xref: PMID:22977056 {source="Europe PMC"} xref: PMID:23016316 {source="Europe PMC"} xref: PMID:23109011 {source="Europe PMC"} xref: PMID:23113731 {source="Europe PMC"} xref: PMID:23114172 {source="Europe PMC"} xref: Reaxys:8132135 {source="Reaxys"} xref: Wikipedia:Nitrofurantoin is_a: CHEBI:24628 ! imidazolidine-2,4-dione is_a: CHEBI:87230 ! nitrofuran antibiotic relationship: has_functional_parent CHEBI:28306 ! semicarbazide relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6N4O5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NXFQHRVNIOXGAQ-YCRREMRBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "238.157" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "238.03382" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(N(/N=C/C=2OC(=CC2)[N+]([O-])=O)CC(N1)=O)=O" xsd:string [Term] id: CHEBI:71543 name: rotenoid namespace: chebi_ontology def: "Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds." [] subset: 3_STAR synonym: "rotenoids" RELATED [ChEBI] xref: Wikipedia:Rotenoids is_a: CHEBI:72544 ! flavonoids is_a: CHEBI:72579 ! tetrahydrochromenochromene [Term] id: CHEBI:71629 name: nisin namespace: chebi_ontology def: "A type-A lantibiotic containing 34 amino acid residues (including lanthionine (Lan), methyllanthionine (MeLan), didehydroalanine (Dha) and didehydroaminobutyric acid (Dhb)) and five thioether bridges. It is obtained by fermentation of the bacterium Lactococcus lactis and shows particular activity against Clostridium botulinum. It is used in the production of various processed foods to suppress Gram-positive spoilage and pathogenic bacteria and so extend shelf life." [] subset: 3_STAR synonym: "E234" RELATED [ChEBI] synonym: "EINECS 215-807-5" RELATED [ChemIDplus] synonym: "N-{[(1S,4S,7S,8S,11R,14S,17R,20S)-7-{[N(2)-({(3R,9S,12S,15S,21S,22S)-21-[(N(2)-{[(6R,9S,10S,15aS)-10-({[(3R,6S,12S,15S)-12-[(2S)-butan-2-yl]-6-isobutyl-15-{[(2Z)-2-(L-isoleucylamino)but-2-enoyl]amino}-9-methylene-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetraazacyclohexadecan-3-yl]carbonyl}amino)-9-methyl-1,4,11-trioxododecahydro-1H,9H-pyrrolo[2,1-i][1,4,7,10]thiatriazacyclotridecin-6-yl]carbonyl}-L-lysyl)amino]-12-isobutyl-15,22-dimethyl-9-[2-(methylsulfanyl)ethyl]-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexaazacyclodocosan-3-yl}carbonyl)-L-asparaginyl-L-methionyl-L-lysyl]amino}-14-(1H-imidazol-5-ylmethyl)-4,8,20-trimethyl-3,6,12,15,21-pentaoxo-9,19-dithia-2,5,13,16,22-pentaazabicyclo[9.9.2]docos-17-yl]carbonyl}-L-seryl-L-isoleucyl-L-histidyl-N-(3-{[(1S)-5-amino-1-carboxypentyl]amino}-3-oxoprop-1-en-2-yl)-L-valinamide" EXACT IUPAC_NAME [IUPAC] synonym: "NSC 112903" RELATED [ChemIDplus] synonym: "NSC-112903" RELATED [ChemIDplus] xref: CAS:1414-45-5 {source="ChemIDplus"} xref: Patent:US2935503 xref: PMID:16247668 {source="Europe PMC"} xref: PMID:21294231 {source="Europe PMC"} xref: PMID:22265294 {source="Europe PMC"} xref: PMID:22691226 {source="Europe PMC"} xref: PMID:22850391 {source="Europe PMC"} xref: Reaxys:8188142 {source="Reaxys"} xref: Wikipedia:Nisin is_a: CHEBI:51026 ! macrocycle is_a: CHEBI:71645 ! type A lantibiotic relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C143H230N42O37S7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C143H230N42O37S7/c1-24-69(11)105(148)135(213)162-82(27-4)118(196)174-94-58-225-59-95(175-123(201)89(48-67(7)8)169-115(193)74(16)158-138(216)107(70(12)25-2)180-132(94)210)133(211)184-112-79(21)229-61-96(160-104(190)56-152-134(212)100-38-34-44-185(100)142(112)220)128(206)164-84(36-29-32-42-145)120(198)182-109-76(18)226-60-97(161-103(189)55-151-117(195)85(39-45-223-22)165-122(200)88(47-66(5)6)168-113(191)72(14)156-102(188)54-153-136(109)214)129(207)171-92(51-101(147)187)125(203)166-86(40-46-224-23)119(197)163-83(35-28-31-41-144)121(199)183-110-77(19)228-63-99-130(208)170-90(49-80-52-149-64-154-80)124(202)176-98(62-227-78(20)111(141(219)177-99)181-116(194)75(17)159-140(110)218)131(209)173-93(57-186)127(205)179-108(71(13)26-3)139(217)172-91(50-81-53-150-65-155-81)126(204)178-106(68(9)10)137(215)157-73(15)114(192)167-87(143(221)222)37-30-33-43-146/h27,52-53,64-72,75-79,83-100,105-112,186H,15-16,24-26,28-51,54-63,144-146,148H2,1-14,17-23H3,(H2,147,187)(H,149,154)(H,150,155)(H,151,195)(H,152,212)(H,153,214)(H,156,188)(H,157,215)(H,158,216)(H,159,218)(H,160,190)(H,161,189)(H,162,213)(H,163,197)(H,164,206)(H,165,200)(H,166,203)(H,167,192)(H,168,191)(H,169,193)(H,170,208)(H,171,207)(H,172,217)(H,173,209)(H,174,196)(H,175,201)(H,176,202)(H,177,219)(H,178,204)(H,179,205)(H,180,210)(H,181,194)(H,182,198)(H,183,199)(H,184,211)(H,221,222)/b82-27-/t69-,70-,71-,72-,75-,76-,77-,78-,79-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94+,95-,96-,97-,98-,99?,100-,105-,106-,107-,108-,109+,110+,111+,112+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NVNLLIYOARQCIX-IPGQQNLLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "3354.07100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "3351.54520" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H](C)[C@H](N)C(=O)N\\C(=C/C)C(=O)N[C@@H]1CSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H]1[C@H](C)SC[C@H](NC(=O)CNC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1[C@H](C)SC[C@H](NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1[C@H](C)SCC2NC(=O)[C@H](NC(=O)[C@H](C)NC1=O)[C@H](C)SC[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC2=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(C)C)C(=O)NC(=C)C(=O)N[C@@H](CCCCN)C(O)=O" xsd:string [Term] id: CHEBI:71644 name: lantibiotic namespace: chebi_ontology def: "A class of peptide antibiotic characterised by the presence of the rare thioether amino acids lanthionine or methyllanthionine, as well as the unsaturated amino acids dehydroalanine and 2-aminoisobutyric acid. In contrast to classical peptide antibiotics, lantibiotics are synthesised from precursor genes using the ribosomal pathway and the characteristic rare amino acids are introduced by posttranslational modification procedues into the lantibiotic precursor peptides ('prepeptides'). Lantibiotics are subdivided into two types: type A have long, flexible structures, while type B have rigid, globular structures." [] subset: 3_STAR synonym: "lantibiotics" RELATED [ChEBI] xref: PMID:10584332 {source="Europe PMC"} xref: PMID:10826980 {source="Europe PMC"} xref: PMID:10931442 {source="Europe PMC"} xref: PMID:11348686 {source="Europe PMC"} xref: PMID:12369187 {source="Europe PMC"} xref: PMID:15700960 {source="Europe PMC"} xref: PMID:16917798 {source="Europe PMC"} xref: PMID:17506681 {source="Europe PMC"} xref: PMID:18220976 {source="Europe PMC"} xref: PMID:19149587 {source="Europe PMC"} xref: PMID:19275538 {source="Europe PMC"} xref: PMID:19393544 {source="Europe PMC"} xref: PMID:21464591 {source="Europe PMC"} xref: PMID:21960309 {source="Europe PMC"} xref: PMID:22329892 {source="Europe PMC"} xref: PMID:8264800 {source="Europe PMC"} xref: PMID:8688628 {source="Europe PMC"} xref: PMID:8775975 {source="Europe PMC"} xref: PMID:9891793 {source="Europe PMC"} xref: Wikipedia:Lantibiotics is_a: CHEBI:15841 ! polypeptide is_a: CHEBI:25903 ! peptide antibiotic [Term] id: CHEBI:71645 name: type A lantibiotic namespace: chebi_ontology def: "Any lantibiotic which has which has a long, flexible structure." [] subset: 3_STAR synonym: "type 1 lantibiotic" RELATED [ChEBI] synonym: "type 1 lantibiotics" RELATED [ChEBI] synonym: "type A lantibiotics" RELATED [ChEBI] synonym: "type-A lantibiotic" RELATED [ChEBI] synonym: "type-A lantibiotics" RELATED [ChEBI] xref: PMID:18848642 {source="Europe PMC"} xref: PMID:21517737 {source="Europe PMC"} is_a: CHEBI:71644 ! lantibiotic [Term] id: CHEBI:71989 name: ortho ester namespace: chebi_ontology def: "Any organooxygen compound that has the general formula RC(OR(1))(OR(2))(OR(3)), where R(1), R(2), R(3) =/= H." [] subset: 3_STAR synonym: "ortho esters" RELATED [ChEBI] synonym: "ortho-ester" RELATED [ChEBI] synonym: "ortho-esters" RELATED [ChEBI] synonym: "orthoester" RELATED [ChEBI] synonym: "orthoesters" RELATED [ChEBI] xref: Wikipedia:Orthoester is_a: CHEBI:36963 ! organooxygen compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO3R4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "60.00890" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.98474" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(O[*])(O[*])O[*]" xsd:string [Term] id: CHEBI:72316 name: virulence factor namespace: chebi_ontology def: "Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host." [] subset: 3_STAR synonym: "virulence factors" RELATED [ChEBI] xref: PMID:22851449 {source="Europe PMC"} xref: Wikipedia:Virulence_factor is_a: CHEBI:27026 ! toxin [Term] id: CHEBI:72544 name: flavonoids namespace: chebi_ontology def: "Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them." [] subset: 3_STAR synonym: "flavonoid" RELATED [ChEBI] xref: Wikipedia:Flavonoids is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72579 name: tetrahydrochromenochromene namespace: chebi_ontology def: "Any chromenochromene resulting from the formal cis-fusion of two dihydro chromene rings, together with their substituted derivatives." [] subset: 3_STAR synonym: "tetrahydrochromenochromenes" RELATED [ChEBI] is_a: CHEBI:133135 ! chromenochromene [Term] id: CHEBI:72581 name: rotenones namespace: chebi_ontology def: "Members of the class of rotenoid which consists of a 6a,12a-dihydrochromeno[3,4-b]chromen-12(6H)-one skeleton and its substituted products." [] subset: 3_STAR is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:71543 ! rotenoid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16O3R12" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "240.16940" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "239.98474" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]c1c([*])c([*])c2C(=O)C3([*])c4c([*])c([*])c([*])c([*])c4OC([*])([*])C3([*])Oc2c1[*]" xsd:string [Term] id: CHEBI:72588 name: semisynthetic derivative namespace: chebi_ontology def: "Any organic molecular entity derived from a natural product by partial chemical synthesis." [] subset: 3_STAR synonym: "semi-synthetic compound" RELATED [ChEBI] synonym: "semi-synthetic compounds" RELATED [ChEBI] synonym: "semi-synthetic derivative" RELATED [ChEBI] synonym: "semi-synthetic derivatives" RELATED [ChEBI] synonym: "semisynthetic compound" RELATED [ChEBI] synonym: "semisynthetic compounds" RELATED [ChEBI] synonym: "semisynthetic derivatives" RELATED [ChEBI] xref: Wikipedia:Semisynthesis is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72600 name: spiroketal namespace: chebi_ontology def: "A cyclic ketal in which the ketal carbon is the only common atom of two rings." [] subset: 3_STAR synonym: "spiroacetal" RELATED [ChEBI] synonym: "spiroacetals" RELATED [ChEBI] synonym: "spiroketals" RELATED [ChEBI] xref: PMID:19262920 {source="Europe PMC"} xref: PMID:20024126 {source="Europe PMC"} xref: PMID:21076755 {source="Europe PMC"} xref: PMID:21604735 {source="Europe PMC"} xref: PMID:21860857 {source="Europe PMC"} xref: PMID:22421755 {source="Europe PMC"} is_a: CHEBI:37948 ! oxaspiro compound is_a: CHEBI:59779 ! cyclic ketal [Term] id: CHEBI:72695 name: organic molecule namespace: chebi_ontology def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." [] subset: 3_STAR synonym: "organic compound" RELATED [ChEBI] synonym: "organic compounds" RELATED [ChEBI] synonym: "organic molecules" RELATED [ChEBI] is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72768 name: aryl hydrocarbon receptor agonist namespace: chebi_ontology def: "An agonist that binds to and activates aryl hydrocarbon receptors (AhRs)." [] subset: 3_STAR synonym: "AHR agonist" RELATED [ChEBI] synonym: "AhR agonist" RELATED [ChEBI] synonym: "AHR agonists" RELATED [ChEBI] synonym: "AhR agonists" RELATED [ChEBI] synonym: "aryl hydrocarbon receptor agonists" RELATED [ChEBI] is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:73080 name: hemiaminal namespace: chebi_ontology def: "Any organic amino compound that has an amino group and a hydroxy group attached to the same carbon atom. Hemiaminals are intermediates in the formation of imines by addition of an amine to an aldehyde or ketone; those derived from primary amines are particularly unstable." [] subset: 3_STAR synonym: "carbinolamine" RELATED [ChEBI] synonym: "carbinolamines" RELATED [ChEBI] synonym: "hemiaminals" RELATED [ChEBI] xref: Wikipedia:Hemiaminal is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:50047 ! organic amino compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNOR4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "43.025" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.00581" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])([*])N([*])[*]" xsd:string [Term] id: CHEBI:73181 name: EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor namespace: chebi_ontology def: "An EC 1.11.1.* (peroxidases) inhibitor that inhibits the action of L-ascorbate peroxidase (EC 1.11.1.11)." [] subset: 3_STAR synonym: "ascorbate peroxidase inhibitor" RELATED [ChEBI] synonym: "ascorbate peroxidase inhibitors" RELATED [ChEBI] synonym: "ascorbic acid peroxidase inhibitor" RELATED [ChEBI] synonym: "ascorbic acid peroxidase inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.11 (L-ascorbate peroxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.11 inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1.11 inhibitors" RELATED [ChEBI] synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitor" RELATED [ChEBI] synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitors" RELATED [ChEBI] synonym: "L-ascorbate peroxidase inhibitor" RELATED [ChEBI] synonym: "L-ascorbate peroxidase inhibitors" RELATED [ChEBI] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitor" RELATED [ChEBI] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitors" RELATED [ChEBI] synonym: "L-ascorbic acid peroxidase inhibitor" RELATED [ChEBI] synonym: "L-ascorbic acid peroxidase inhibitors" RELATED [ChEBI] synonym: "L-ascorbic acid-specific peroxidase inhibitor" RELATED [ChEBI] synonym: "L-ascorbic acid-specific peroxidase inhibitors" RELATED [ChEBI] xref: Wikipedia:L-ascorbate_peroxidase is_a: CHEBI:75381 ! EC 1.11.1.* (peroxidases) inhibitor [Term] id: CHEBI:73216 name: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor namespace: chebi_ontology alt_id: CHEBI:76765 def: "Any hydrolase inhibitor that interferes with the action of a hydrolase which acts on acid anhydrides (EC 3.6.*.*)." [] subset: 3_STAR synonym: "acid anhydride hydrolase inhibitor" RELATED [ChEBI] synonym: "acid anhydride hydrolase inhibitors" RELATED [ChEBI] synonym: "EC 3.6 inhibitor" RELATED [ChEBI] synonym: "EC 3.6 inhibitors" RELATED [ChEBI] synonym: "EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.* inhibitor" RELATED [ChEBI] synonym: "EC 3.6.* inhibitors" RELATED [ChEBI] synonym: "EC 3.6.*.* inhibitor" RELATED [ChEBI] synonym: "EC 3.6.*.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [ChEBI] synonym: "inhibitors of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:73336 name: vulnerary namespace: chebi_ontology def: "A drug used in treating and healing of wounds." [] subset: 3_STAR synonym: "vulneraries" RELATED [ChEBI] synonym: "wound-healing agent" RELATED [ChEBI] synonym: "wound-healing agents" RELATED [ChEBI] synonym: "wound-healing drug" RELATED [ChEBI] synonym: "wound-healing drugs" RELATED [ChEBI] xref: Wikipedia:Wound_healing is_a: CHEBI:23888 ! drug [Term] id: CHEBI:73474 name: acetylenic compound namespace: chebi_ontology def: "Any organic molecule containing a C#C bond." [] subset: 3_STAR synonym: "acetylenic compounds" RELATED [ChEBI] synonym: "C#C containing compound" RELATED [ChEBI] synonym: "C#C containing compounds" RELATED [ChEBI] synonym: "C#C-containing compound" RELATED [ChEBI] synonym: "C#C-containing compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "24.021" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "24.00000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C#C[*]" xsd:string [Term] id: CHEBI:73537 name: 1,8-naphthyridine derivative namespace: chebi_ontology def: "Any naphthyridine derivative that is a derivative of 1,8-naphthyridine." [] subset: 3_STAR synonym: "1,8-naphthyridine derivatives" RELATED [ChEBI] is_a: CHEBI:73539 ! naphthyridine derivative relationship: has_parent_hydride CHEBI:36628 ! 1,8-naphthyridine [Term] id: CHEBI:73539 name: naphthyridine derivative namespace: chebi_ontology def: "Any organonitrogen heterocyclic compound that is a derivative of a naphthyridine." [] subset: 3_STAR synonym: "naphthyridine derivatives" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound relationship: has_parent_hydride CHEBI:36624 ! naphthyridine [Term] id: CHEBI:73678 name: tobramycin(5+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the five amino groups of tobramycin." [] subset: 3_STAR synonym: "(1S,2S,3R,4S,6R)-4,6-diazaniumyl-3-[(2,6-diazaniumyl-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-azaniumyl-3-deoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "tobramycin" RELATED [UniProt] xref: PMID:22383337 {source="SUBMITTER"} is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:28864 ! tobramycin property_value: http://purl.obolibrary.org/obo/chebi/charge "+5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H42N5O9" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/p+5/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NLVFBUXFDBBNBW-PBSUHMDJSA-S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "472.55420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "472.29551" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C[C@H]1O[C@H](O[C@@H]2[C@@H]([NH3+])C[C@@H]([NH3+])[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H]([NH3+])[C@H]3O)[C@H]2O)[C@H]([NH3+])C[C@@H]1O" xsd:string [Term] id: CHEBI:73754 name: thiosugar namespace: chebi_ontology def: "A carbohydrate derivative in which one or more of the oxygens or hydroxy groups of the parent carbohydrate is replaced by sulfur or -SR, where R can be hydrogen or any group." [] subset: 3_STAR synonym: "thiosugars" RELATED [ChEBI] xref: PMID:16240117 {source="Europe PMC"} xref: PMID:23330717 {source="Europe PMC"} is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:73913 name: antifolate namespace: chebi_ontology def: "An antimetabolite that impairs the action of folic acids" [] subset: 3_STAR synonym: "antifolates" RELATED [ChEBI] synonym: "folic acid antagonist" RELATED [ChEBI] synonym: "folic acid antagonists" RELATED [ChEBI] xref: Wikipedia:Antifolate is_a: CHEBI:35221 ! antimetabolite [Term] id: CHEBI:74159 name: D-cycloserine zwitterion namespace: chebi_ontology def: "A zwitterion resulting from the transfer of a proton from the ring nitrogen to the primary amino group of D-cycloserine. The major species at pH 7.3." [] subset: 3_STAR synonym: "(+)-4-amino-3-isoxazolidinone zwitterion" RELATED [ChEBI] synonym: "(4R)-4-aminoisoxazolidin-3-one zwitterion" RELATED [ChEBI] synonym: "(4R)-4-ammonio-3-oxo-1,2-oxazolidin-2-ide" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-cycloserine zwitterion" RELATED [ChEBI] synonym: "cycloserine zwitterion" RELATED [ChEBI] synonym: "D-4-amino-3-isoxazolidinone zwitterion" RELATED [ChEBI] xref: MetaCyc:CPD-2482 {source="SUBMITTER"} xref: PMID:20086163 {source="SUBMITTER"} xref: PMID:23529730 {source="SUBMITTER"} is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:40009 ! D-cycloserine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYDCUQKUCUHJBH-UWTATZPHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "102.09190" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.04293" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1([NH3+])CO[N-]C1=O" xsd:string [Term] id: CHEBI:7451 name: naftifine namespace: chebi_ontology def: "A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections." [] subset: 3_STAR synonym: "(2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine" EXACT IUPAC_NAME [IUPAC] synonym: "(E)-N-cinnamyl-N-methyl-1-naphthalenemethylamine" RELATED [ChemIDplus] synonym: "naftifin" RELATED [ChemIDplus] synonym: "naftifina" RELATED INN [WHO_MedNet] synonym: "naftifine" RELATED INN [KEGG_DRUG] synonym: "naftifine" RELATED INN [WHO_MedNet] synonym: "naftifinum" RELATED INN [WHO_MedNet] synonym: "trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine" RELATED [ChEBI] xref: CAS:65472-88-0 {source="ChemIDplus"} xref: CAS:65472-88-0 {source="KEGG COMPOUND"} xref: Drug_Central:1872 {source="DrugCentral"} xref: DrugBank:DB00735 xref: HMDB:HMDB0014873 xref: KEGG:C08071 xref: KEGG:D08245 xref: Patent:BE853976 xref: Patent:US4282251 xref: PMID:18212112 {source="Europe PMC"} xref: PMID:24196340 {source="Europe PMC"} xref: PMID:25294700 {source="Europe PMC"} xref: PMID:6388170 {source="Europe PMC"} xref: Reaxys:2983617 {source="Reaxys"} xref: Wikipedia:Naftifine is_a: CHEBI:25477 ! naphthalenes is_a: CHEBI:32876 ! tertiary amine is_a: CHEBI:87127 ! allylamine antifungal drug relationship: RO:0000087 CHEBI:59285 ! has role EC 1.14.13.132 (squalene monooxygenase) inhibitor relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H21N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OZGNYLLQHRPOBR-DHZHZOJOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "287.39810" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "287.16740" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C\\C=C\\c1ccccc1)Cc1cccc2ccccc12" xsd:string [Term] id: CHEBI:74783 name: astringent namespace: chebi_ontology def: "A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions." [] subset: 3_STAR synonym: "adstringent" RELATED [ChEBI] synonym: "adstringents" RELATED [ChEBI] synonym: "astringents" RELATED [ChEBI] xref: Wikipedia:Astringent is_a: CHEBI:23888 ! drug [Term] id: CHEBI:74818 name: heteroaryl hydroxy compound namespace: chebi_ontology def: "Any organic aromatic compound having one or more hydroxy groups attached to a heteroarene ring." [] subset: 3_STAR synonym: "hetaryl hydroxy compound" RELATED [ChEBI] synonym: "hetaryl hydroxy compounds" RELATED [ChEBI] synonym: "heteroaromatic hydroxy compound" RELATED [ChEBI] synonym: "heteroaromatic hydroxy compounds" RELATED [ChEBI] synonym: "heteroaryl hydroxy compounds" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:7489 name: neamine namespace: chebi_ontology alt_id: CHEBI:46591 alt_id: CHEBI:481318 def: "2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "2-desoxy-4-O-(2,6-diamino-2,6-didesoxy-alpha-D-glucopyranosyl)-D-streptamin" RELATED [ChemIDplus] synonym: "4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine" RELATED [ChemIDplus] synonym: "Neamine" EXACT [KEGG_COMPOUND] synonym: "neamine" EXACT [ChEMBL] synonym: "Neomycin A" RELATED [KEGG_COMPOUND] xref: CAS:3947-65-7 {source="KEGG COMPOUND"} xref: CAS:3947-65-7 {source="ChemIDplus"} xref: DrugBank:DB04808 xref: KEGG:C01441 xref: PDBeChem:XXX xref: PMID:1008820 {source="Europe PMC"} xref: PMID:16361562 {source="Europe PMC"} xref: PMID:16870442 {source="ChEMBL"} xref: PMID:16942021 {source="ChEMBL"} xref: PMID:17317190 {source="ChEMBL"} xref: PMID:17416529 {source="ChEMBL"} xref: PMID:19276260 {source="Europe PMC"} xref: PMID:20000576 {source="Europe PMC"} xref: PMID:21135992 {source="Europe PMC"} xref: Reaxys:26714 {source="Reaxys"} is_a: CHEBI:47779 ! aminoglycoside is_a: CHEBI:53628 ! 2,6-dideoxy-alpha-D-glucoside relationship: is_conjugate_base_of CHEBI:65076 ! neamine(4+) relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H26N4O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SYJXFKPQNSDJLI-HKEUSBCWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "322.35800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "322.18523" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:7507 name: neomycin namespace: chebi_ontology def: "A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections." [] subset: 3_STAR synonym: "Neomycin" EXACT [KEGG_COMPOUND] xref: CAS:1404-04-2 {source="KEGG COMPOUND"} xref: DrugBank:DB00994 xref: KEGG:C00384 xref: KEGG:D08260 is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic relationship: has_part CHEBI:53634 ! neomycin C relationship: has_part CHEBI:7489 ! neamine relationship: has_part CHEBI:7508 ! framycetin [Term] id: CHEBI:7508 name: framycetin namespace: chebi_ontology alt_id: CHEBI:44577 def: "A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "Fradiomycin B" RELATED [KEGG_COMPOUND] synonym: "framicetina" RELATED INN [ChemIDplus] synonym: "Framycetin" EXACT [ChemIDplus] synonym: "Framycetin" EXACT [KEGG_COMPOUND] synonym: "framycetine" RELATED INN [ChemIDplus] synonym: "framycetinum" RELATED INN [ChemIDplus] synonym: "Neomycin B" RELATED [KEGG_COMPOUND] xref: Beilstein:101621 {source="Beilstein"} xref: CAS:119-04-0 {source="ChemIDplus"} xref: CAS:119-04-0 {source="KEGG COMPOUND"} xref: Drug_Central:1896 {source="DrugCentral"} xref: DrugBank:DB00452 xref: KEGG:C01737 xref: KEGG:D05140 xref: LINCS:LSM-5787 xref: MetaCyc:CPD-14142 xref: PDBeChem:NMY xref: PMID:25129497 {source="Europe PMC"} xref: PMID:25230155 {source="Europe PMC"} xref: PMID:25450807 {source="Europe PMC"} xref: PMID:25588492 {source="Europe PMC"} xref: PMID:8548964 {source="Europe PMC"} xref: Reaxys:101621 {source="Reaxys"} xref: VSDB:1783 is_a: CHEBI:47779 ! aminoglycoside relationship: is_conjugate_base_of CHEBI:87835 ! framycetin(6+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H46N6O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PGBHMTALBVVCIT-VCIWKGPPSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "614.64370" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "614.31229" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:7528 name: netilmycin namespace: chebi_ontology subset: 3_STAR synonym: "(1S,2S,3R,4S,6R)-4-amino-3-[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yloxy]-6-(ethylamino)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "1-N-Ethylsisomicin" RELATED [ChemIDplus] synonym: "Netilmicin" RELATED [KEGG_COMPOUND] synonym: "O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-N(1)-ethyl-D-streptamine" RELATED [ChemIDplus] xref: CAS:56391-56-1 {source="KEGG COMPOUND"} xref: CAS:56391-56-1 {source="ChemIDplus"} xref: DrugBank:DB00955 xref: KEGG:C07657 xref: KEGG:D08268 is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic is_a: CHEBI:28079 ! beta-L-arabinoside is_a: CHEBI:63367 ! monosaccharide derivative relationship: has_functional_parent CHEBI:27955 ! streptamine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H41N5O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H41N5O7/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)15(28)17(13)33-20-21(2,29)18(25-3)14(27)9-30-20/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3/t11-,12+,13-,14+,15+,16-,17+,18-,19-,20-,21-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZBGPYVZLYBDXKO-HILBYHGXSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "475.57974" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "475.30060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN[C@@H]1C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@H](O)[C@@H](NC)[C@@]1(C)O" xsd:string [Term] id: CHEBI:75282 name: ergosterol biosynthesis inhibitor namespace: chebi_ontology def: "Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol." [] subset: 3_STAR synonym: "ergosterol biosynthesis inhibitors" RELATED [ChEBI] xref: PMID:12604527 {source="Europe PMC"} xref: PMID:19835945 {source="Europe PMC"} is_a: CHEBI:83317 ! sterol biosynthesis inhibitor [Term] id: CHEBI:75283 name: miltefosine namespace: chebi_ontology def: "A phospholipid that is the hexadecyl monoester of phosphocholine." [] subset: 3_STAR synonym: "Hexadecylphosphocholine" RELATED [ChemIDplus] synonym: "Hexadecylphosphorylcholine" RELATED [ChemIDplus] synonym: "miltefosina" RELATED INN [ChemIDplus] synonym: "miltefosine" RELATED INN [WHO_MedNet] synonym: "miltefosine" RELATED INN [KEGG_DRUG] synonym: "miltefosinum" RELATED INN [ChemIDplus] synonym: "monohexadecylphosphocholine" RELATED [ChEBI] synonym: "monohexadecylphosphorylcholine" RELATED [ChEBI] xref: CAS:58066-85-6 {source="KEGG DRUG"} xref: CAS:58066-85-6 {source="ChemIDplus"} xref: Drug_Central:1810 {source="DrugCentral"} xref: KEGG:D02494 xref: PMID:22385017 {source="Europe PMC"} xref: PMID:22935677 {source="Europe PMC"} xref: PMID:22995097 {source="Europe PMC"} xref: PMID:23136856 {source="Europe PMC"} xref: PMID:23165465 {source="Europe PMC"} xref: PMID:23199340 {source="Europe PMC"} xref: PMID:23239091 {source="Europe PMC"} xref: PMID:23243111 {source="Europe PMC"} xref: PMID:23434530 {source="Europe PMC"} xref: PMID:23434716 {source="Europe PMC"} xref: PMID:23468121 {source="Europe PMC"} xref: PMID:23601234 {source="Europe PMC"} xref: PMID:23673723 {source="Europe PMC"} xref: PMID:23723490 {source="Europe PMC"} xref: PMID:23729024 {source="Europe PMC"} xref: PMID:23738749 {source="Europe PMC"} xref: PMID:23740007 {source="Europe PMC"} xref: PMID:23811261 {source="Europe PMC"} xref: PMID:23811637 {source="Europe PMC"} xref: PMID:23861311 {source="Europe PMC"} xref: PMID:23871798 {source="Europe PMC"} xref: PMID:23890327 {source="Europe PMC"} xref: PMID:23930349 {source="Europe PMC"} xref: Reaxys:3690495 {source="Reaxys"} xref: Wikipedia:Miltefosine is_a: CHEBI:16247 ! phospholipid is_a: CHEBI:36700 ! phosphocholines relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:37699 ! has role protein kinase inhibitor relationship: RO:0000087 CHEBI:50846 ! has role immunomodulator relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H46NO4P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PQLXHQMOHUQAKB-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "407.56800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "407.31645" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C" xsd:string [Term] id: CHEBI:75381 name: EC 1.11.1.* (peroxidases) inhibitor namespace: chebi_ontology def: "An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any of the peroxidases (EC 1.11.1.*)." [] subset: 3_STAR synonym: "EC 1.11.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1 inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.* (peroxidase) inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1.* (peroxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.* (peroxidases) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of peroxidases" RELATED [ChEBI] synonym: "inhibitors of peroxidases" RELATED [ChEBI] synonym: "peroxidases inhibitors" RELATED [ChEBI] xref: Wikipedia:Peroxidases is_a: CHEBI:76738 ! EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor [Term] id: CHEBI:75592 name: L-cycloserine namespace: chebi_ontology def: "A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora." [] subset: 3_STAR synonym: "(-)-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "(-)-4-aminoisoxazolidin-3-one" RELATED [ChEBI] synonym: "(-)-cycloserine" RELATED [ChEBI] synonym: "(4S)-4-amino-1,2-oxazolidin-3-one" EXACT IUPAC_NAME [IUPAC] synonym: "(4S)-4-aminoisoxazolidin-3-one" RELATED [IUPAC] synonym: "(S)-(-)-cycloserine" RELATED [ChemIDplus] synonym: "(S)-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "(S)-4-amino-isoxazolidin-3-one" RELATED [ChEBI] synonym: "cyclo-L-serine" RELATED [ChemIDplus] synonym: "L-4-aminoisoxazolidin-3-one" RELATED [ChEBI] synonym: "L-CS" RELATED [ChEBI] synonym: "levcicloserina" RELATED INN [ChemIDplus] synonym: "levcycloserine" RELATED INN [WHO_MedNet] synonym: "levcycloserine" RELATED INN [ChemIDplus] synonym: "levcycloserinum" RELATED INN [ChemIDplus] xref: CAS:339-72-0 {source="ChemIDplus"} xref: DrugBank:DB00260 xref: HMDB:HMDB0014405 xref: KEGG:D04706 xref: LINCS:LSM-5639 xref: MetaCyc:CPD-2483 xref: PMID:19932170 {source="Europe PMC"} xref: PMID:3430071 {source="Europe PMC"} xref: PMID:3771514 {source="Europe PMC"} xref: PMID:4150977 {source="Europe PMC"} xref: PMID:638858 {source="Europe PMC"} xref: PMID:6501090 {source="Europe PMC"} xref: PMID:6723595 {source="Europe PMC"} xref: PMID:7353584 {source="Europe PMC"} xref: PMID:8556395 {source="Europe PMC"} xref: Reaxys:80799 {source="Reaxys"} is_a: CHEBI:23503 ! 4-amino-1,2-oxazolidin-3-one relationship: is_enantiomer_of CHEBI:40009 ! D-cycloserine relationship: RO:0000087 CHEBI:35623 ! has role anticonvulsant relationship: RO:0000087 CHEBI:59647 ! has role EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor relationship: RO:0000087 CHEBI:64946 ! has role anti-HIV agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYDCUQKUCUHJBH-REOHCLBHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "102.09190" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.04293" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(N)CONC1=O" xsd:string [Term] id: CHEBI:75596 name: EC 5.* (isomerase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*)." [] subset: 3_STAR synonym: "EC 5.* (isomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.* inhibitor" RELATED [ChEBI] synonym: "EC 5.* inhibitors" RELATED [ChEBI] synonym: "EC 5.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 5.*.*.* inhibitors" RELATED [ChEBI] synonym: "isomerase (EC 5.*) inhibitor" RELATED [ChEBI] synonym: "isomerase (EC 5.*) inhibitors" RELATED [ChEBI] synonym: "isomerase inhibitor" RELATED [ChEBI] synonym: "isomerase inhibitors" RELATED [ChEBI] is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:75606 name: hydroxamic acid ester namespace: chebi_ontology def: "A carboxamide that is a hydroxamic acid in which the hydrogen of the hydroxy group is replaced by an organyl group." [] subset: 3_STAR synonym: "hydroxamate ester" RELATED [ChEBI] synonym: "hydroxamate esters" RELATED [ChEBI] synonym: "hydroxamic acid esters" RELATED [ChEBI] synonym: "RC(O)NHOR'" RELATED [ChEBI] synonym: "RCONHOR'" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide relationship: has_functional_parent CHEBI:24650 ! hydroxamic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNO2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "59.02410" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.00073" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)NO[*]" xsd:string [Term] id: CHEBI:75616 name: gentamicin C(5+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the five amino groups of any gentamicin C." [] subset: 3_STAR synonym: "gentamicin C" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:28417 ! gentamycin C property_value: http://purl.obolibrary.org/obo/chebi/charge "+5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H42N5O7R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "452.567" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "452.30842" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H]([NH3+])C[C@H]([NH3+])[C@@H](O[C@H]3O[C@@H](CC[C@H]3[NH3+])[C@@H]([*])[NH2+][*])[C@@H]2O)OC[C@]1(C)O" xsd:string [Term] id: CHEBI:7566 name: Nifurtimox namespace: chebi_ontology subset: 2_STAR synonym: "Bayer 2502" RELATED [DrugCentral] synonym: "lampit" RELATED [DrugCentral] synonym: "Nifurtimox" EXACT [KEGG_COMPOUND] xref: CAS:23256-30-6 {source="KEGG COMPOUND"} xref: Drug_Central:1929 {source="DrugCentral"} xref: KEGG:C08002 xref: KEGG:D00833 is_a: CHEBI:87230 ! nitrofuran antibiotic property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H13N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ARFHIAQFJWUCFH-IZZDOVSWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "287.294" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "287.05759" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1CS(=O)(=O)CCN1\\N=C\\c1ccc(o1)[N+]([O-])=O" xsd:string [Term] id: CHEBI:75763 name: eukaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." [] subset: 3_STAR synonym: "eukaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:75767 name: animal metabolite namespace: chebi_ontology alt_id: CHEBI:77721 alt_id: CHEBI:77743 def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." [] subset: 3_STAR synonym: "animal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:75768 name: mammalian metabolite namespace: chebi_ontology alt_id: CHEBI:77464 alt_id: CHEBI:77744 def: "Any animal metabolite produced during a metabolic reaction in mammals." [] subset: 3_STAR synonym: "mammalian metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:75769 name: B vitamin namespace: chebi_ontology def: "Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such)." [] subset: 3_STAR synonym: "B vitamins" RELATED [ChEBI] synonym: "B-group vitamin" RELATED [ChEBI] synonym: "B-group vitamins" RELATED [ChEBI] synonym: "vitamin B" RELATED [ChEBI] xref: MetaCyc:B-vitamins xref: PMID:22743781 {source="Europe PMC"} xref: PMID:23093174 {source="Europe PMC"} xref: PMID:23238962 {source="Europe PMC"} xref: PMID:23449527 {source="Europe PMC"} xref: PMID:23462586 {source="Europe PMC"} xref: PMID:23690582 {source="Europe PMC"} xref: Wikipedia:B_vitamin is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound relationship: RO:0000087 CHEBI:27314 ! has role water-soluble vitamin (role) relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical [Term] id: CHEBI:75771 name: mouse metabolite namespace: chebi_ontology def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." [] subset: 3_STAR synonym: "mouse metabolites" RELATED [ChEBI] synonym: "Mus musculus metabolite" RELATED [ChEBI] synonym: "Mus musculus metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:75772 name: Saccharomyces cerevisiae metabolite namespace: chebi_ontology alt_id: CHEBI:76949 alt_id: CHEBI:76951 def: "Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." [] subset: 3_STAR synonym: "baker's yeast metabolite" RELATED [ChEBI] synonym: "baker's yeast metabolites" RELATED [ChEBI] synonym: "baker's yeast secondary metabolite" RELATED [ChEBI] synonym: "baker's yeast secondary metabolites" RELATED [ChEBI] synonym: "S. cerevisiae metabolite" RELATED [ChEBI] synonym: "S. cerevisiae metabolites" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolite" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [ChEBI] is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:75787 name: prokaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." [] subset: 3_STAR synonym: "prokaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:75929 name: D-cycloserine(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of D-cycloserine, obtained by protonation of the amino group." [] subset: 3_STAR synonym: "(4R)-3-oxo-1,2-oxazolidin-4-aminium" EXACT IUPAC_NAME [IUPAC] synonym: "D-cycloserine" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:40009 ! D-cycloserine property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/p+1/t2-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYDCUQKUCUHJBH-UWTATZPHSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "103.09990" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "103.05020" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H]1CONC1=O" xsd:string [Term] id: CHEBI:75954 name: vancomycin aglycone zwitterion namespace: chebi_ontology def: "A peptide zwitterion obtained by transfer of a proton from the carboxy to the amino group of vancomycin aglycone." [] subset: 3_STAR xref: MetaCyc:CPD-15745 {source="SUBMITTER"} xref: PMID:11470430 {source="SUBMITTER"} is_a: CHEBI:60466 ! peptide zwitterion relationship: is_conjugate_acid_of CHEBI:77981 ! vancomycin aglycone(1-) relationship: is_tautomer_of CHEBI:47724 ! vancomycin aglycone property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H52Cl2N8O17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H52Cl2N8O17/c1-19(2)10-29(57-3)47(71)62-42-44(68)21-5-8-33(27(54)12-21)79-35-14-23-15-36(46(35)70)80-34-9-6-22(13-28(34)55)45(69)43-52(76)61-41(53(77)78)26-16-24(64)17-32(66)38(26)25-11-20(4-7-31(25)65)39(49(73)63-43)60-50(74)40(23)59-48(72)30(18-37(56)67)58-51(42)75/h4-9,11-17,19,29-30,39-45,57,64-66,68-70H,10,18H2,1-3H3,(H2,56,67)(H,58,75)(H,59,72)(H,60,74)(H,61,76)(H,62,71)(H,63,73)(H,77,78)/t29-,30+,39-,40-,41+,42-,43+,44-,45-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JHIKFOISFAQTJQ-YZANBJIASA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1143.92900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1142.28275" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C([O-])=O)c3O)c(Cl)c2" xsd:string [Term] id: CHEBI:76042 name: aromatic amino-acid zwitterion namespace: chebi_ontology def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid." [] subset: 3_STAR synonym: "an aromatic amino-acid" RELATED [UniProt] synonym: "aromatic amino-acid zwitterions" RELATED [ChEBI] xref: MetaCyc:Aromatic-Amino-Acids {source="SUBMITTER"} is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_tautomer_of CHEBI:33856 ! aromatic amino acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C([*])C([O-])=O" xsd:string [Term] id: CHEBI:76206 name: xenobiotic metabolite namespace: chebi_ontology def: "Any metabolite produced by metabolism of a xenobiotic compound." [] subset: 3_STAR synonym: "xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76395 name: EC 2.3.1.48 (histone acetyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48)." [] subset: 3_STAR synonym: "acetyl-CoA:histone acetyltransferase inhibitor" RELATED [ChEBI] synonym: "acetyl-CoA:histone acetyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.48 (histone acetyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.48 inhibitor" RELATED [ChEBI] synonym: "EC 2.3.1.48 inhibitors" RELATED [ChEBI] synonym: "HAT inhibitor" RELATED [ChEBI] synonym: "HAT inhibitors" RELATED [ChEBI] synonym: "histone acetokinase inhibitor" RELATED [ChEBI] synonym: "histone acetokinase inhibitors" RELATED [ChEBI] synonym: "histone acetylase inhibitor" RELATED [ChEBI] synonym: "histone acetylase inhibitors" RELATED [ChEBI] synonym: "histone acetyltransferase (EC 2.3.1.48) inhibitor" RELATED [ChEBI] synonym: "histone acetyltransferase (EC 2.3.1.48) inhibitors" RELATED [ChEBI] synonym: "histone acetyltransferase inhibitor" RELATED [ChEBI] synonym: "histone acetyltransferase inhibitors" RELATED [ChEBI] synonym: "histone transacetylase inhibitor" RELATED [ChEBI] synonym: "histone transacetylase inhibitors" RELATED [ChEBI] synonym: "nucleosome-histone acetyltransferase inhibitor" RELATED [ChEBI] synonym: "nucleosome-histone acetyltransferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Histone_acetyltransferase is_a: CHEBI:76878 ! EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor [Term] id: CHEBI:76507 name: marine metabolite namespace: chebi_ontology alt_id: CHEBI:77078 def: "Any metabolite produced during a metabolic reaction in marine macro- and microorganisms." [] subset: 3_STAR synonym: "marine metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76567 name: polyunsaturated fatty acid anion namespace: chebi_ontology def: "Any unsaturated fatty acid anion containing more than one C-C unsaturated bond. Major species at pH 7.3." [] subset: 3_STAR synonym: "polyunsaturated fatty acid anions" RELATED [ChEBI] synonym: "PUFA" RELATED [SUBMITTER] is_a: CHEBI:2580 ! unsaturated fatty acid anion relationship: is_conjugate_base_of CHEBI:26208 ! polyunsaturated fatty acid [Term] id: CHEBI:7660 name: nystatin namespace: chebi_ontology def: "A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections." [] subset: 3_STAR synonym: "Barstatin 100" RELATED BRAND_NAME [ChemIDplus] synonym: "Biofanal" RELATED BRAND_NAME [ChemIDplus] synonym: "Candex" RELATED BRAND_NAME [ChemIDplus] synonym: "Diastatin" RELATED BRAND_NAME [ChemIDplus] synonym: "Fungicidin" RELATED BRAND_NAME [ChemIDplus] synonym: "Herniocid" RELATED BRAND_NAME [ChemIDplus] synonym: "Korostatin" RELATED BRAND_NAME [ChemIDplus] synonym: "Mycostatin" RELATED BRAND_NAME [KEGG_DRUG] synonym: "nystatin" RELATED INN [WHO_MedNet] synonym: "nystatina" RELATED INN [WHO_MedNet] synonym: "nystatine" RELATED INN [WHO_MedNet] synonym: "nystatinum" RELATED INN [WHO_MedNet] synonym: "Nystex" RELATED BRAND_NAME [ChemIDplus] synonym: "Nystop" RELATED BRAND_NAME [ChemIDplus] xref: CAS:1400-61-9 {source="ChemIDplus"} xref: Drug_Central:1977 {source="DrugCentral"} xref: DrugBank:DB00646 xref: KEGG:C06572 xref: KEGG:D00202 xref: LIPID_MAPS_instance:LMPK06000001 {source="LIPID MAPS"} xref: PMID:10427694 {source="Europe PMC"} xref: PMID:12987085 {source="Europe PMC"} xref: PMID:16374455 {source="Europe PMC"} xref: PMID:16740372 {source="Europe PMC"} xref: PMID:17422416 {source="Europe PMC"} xref: PMID:18551578 {source="Europe PMC"} xref: PMID:33141477 {source="Europe PMC"} xref: PMID:33279513 {source="Europe PMC"} xref: PMID:33387388 {source="Europe PMC"} xref: PMID:33389775 {source="Europe PMC"} xref: PMID:34033502 {source="Europe PMC"} xref: PMID:34160701 {source="Europe PMC"} xref: PMID:34657217 {source="Europe PMC"} xref: PMID:34714482 {source="Europe PMC"} xref: PMID:34738720 {source="Europe PMC"} xref: PMID:34946737 {source="Europe PMC"} xref: PMID:35178173 {source="Europe PMC"} xref: PMID:35195155 {source="Europe PMC"} xref: PMID:35299602 {source="Europe PMC"} xref: PMID:35549875 {source="Europe PMC"} xref: Wikipedia:Nystatin is_a: CHEBI:22507 ! aminoglycoside antibiotic is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:26191 ! polyol is_a: CHEBI:36244 ! dicarboxylic acid monoester is_a: CHEBI:48121 ! polyene is_a: CHEBI:60004 ! mixture is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: has_part CHEBI:192979 ! nystatin A2 relationship: has_part CHEBI:31927 ! nystatin A3 relationship: has_part CHEBI:473992 ! nystatin A1 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C47H75NO17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "926.107" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "925.50350" xsd:string [Term] id: CHEBI:76661 name: EC 2.3.* (acyltransferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor that interferes with the action of an acyltransferase (EC 2.3.*.*)." [] subset: 3_STAR synonym: "acyltransferase inhibitor" RELATED [ChEBI] synonym: "acyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.3.* (acyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.* inhibitor" RELATED [ChEBI] synonym: "EC 2.3.* inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76662 name: EC 2.4.* (glycosyltransferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor inhibiting the action of a glycosyltransferase (EC 2.4.*.*)." [] subset: 3_STAR synonym: "EC 2.4.* (glycosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.* inhibitor" RELATED [ChEBI] synonym: "EC 2.4.* inhibitors" RELATED [ChEBI] synonym: "glycosyltransferase (EC 2.4.*) inhibitor" RELATED [ChEBI] synonym: "glycosyltransferase (EC 2.4.*) inhibitors" RELATED [ChEBI] synonym: "glycosyltransferase inhibitor" RELATED [ChEBI] synonym: "glycosyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76663 name: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*)." [] subset: 3_STAR synonym: "alkyl/aryl (non-methyl) transferase inhibitor" RELATED [ChEBI] synonym: "alkyl/aryl (non-methyl) transferase inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.5.1.* inhibitors" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase inhibitor" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase inhibitors" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase inhibitor" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76834 ! EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor [Term] id: CHEBI:76668 name: EC 2.7.* (P-containing group transferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*)." [] subset: 3_STAR synonym: "EC 2.7.* (P-containing group transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitor" RELATED [ChEBI] synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.* inhibitors" RELATED [ChEBI] synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitor" RELATED [ChEBI] synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitors" RELATED [ChEBI] synonym: "phosphorus-containing group transferase inhibitor" RELATED [ChEBI] synonym: "phosphorus-containing group transferase inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76697 name: EC 5.99.* (other isomerases) inhibitor namespace: chebi_ontology def: "An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*)." [] subset: 3_STAR synonym: "EC 5.99.* (miscellaneous isomerases) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.* (miscellaneous isomerases) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.* (other isomerase) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.* (other isomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.* (other isomerases) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.* inhibitor" RELATED [ChEBI] synonym: "EC 5.99.* inhibitors" RELATED [ChEBI] is_a: CHEBI:75596 ! EC 5.* (isomerase) inhibitor [Term] id: CHEBI:76710 name: EC 4.* (lyase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor which interferes with the action of a lyase (EC 4.*.*.*). Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation." [] subset: 3_STAR synonym: "EC 4.* (lyase) inhibitors" RELATED [ChEBI] synonym: "EC 4.* inhibitor" RELATED [ChEBI] synonym: "EC 4.* inhibitors" RELATED [ChEBI] synonym: "EC 4.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 4.*.*.* inhibitors" RELATED [ChEBI] synonym: "lyase (EC 4.*) inhibitor" RELATED [ChEBI] synonym: "lyase (EC 4.*) inhibitorS" RELATED [ChEBI] synonym: "lyase inhibitor" RELATED [ChEBI] synonym: "lyase inhibitors" RELATED [ChEBI] xref: Wikipedia:Lyase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76712 name: EC 4.2.* (C-O lyase) inhibitor namespace: chebi_ontology def: "A lyase inhibitor which inhibits the action of a C-O lyase (EC 4.2.*.*)." [] subset: 3_STAR synonym: "C-O lyase (EC 4.2.*) inhibitor" RELATED [ChEBI] synonym: "C-O lyase (EC 4.2.*) inhibitors" RELATED [ChEBI] synonym: "C-O lyase inhibitor" RELATED [ChEBI] synonym: "C-O lyase inhibitors" RELATED [ChEBI] synonym: "EC 4.2.* (C-O lyase) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.* inhibitor" RELATED [ChEBI] synonym: "EC 4.2.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76710 ! EC 4.* (lyase) inhibitor [Term] id: CHEBI:76725 name: EC 1.* (oxidoreductase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." [] subset: 3_STAR synonym: "EC 1.* (oxidoreductase) inhibitors" RELATED [ChEBI] synonym: "EC 1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase (EC 1.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase (EC 1.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase inhibitor" RELATED [ChEBI] synonym: "oxidoreductase inhibitors" RELATED [ChEBI] xref: Wikipedia:Oxidoreductase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76727 name: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the aldehyde or oxo group of donors (EC 1.2.*.*)." [] subset: 3_STAR synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor" RELATED [ChEBI] synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.* inhibitor" RELATED [ChEBI] synonym: "EC 1.2.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76729 name: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*)." [] subset: 3_STAR synonym: "EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.3.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76730 name: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH2 group of donors (EC 1.4.*.*)." [] subset: 3_STAR synonym: "EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor" EXACT [ChEBI] synonym: "EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.* inhibitor" RELATED [ChEBI] synonym: "EC 1.4.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH2 group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH2 group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH2 group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH2 group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donor inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donor inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76731 name: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*)." [] subset: 3_STAR synonym: "EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors" RELATED [ChEBI] synonym: "EC 1.5.* inhibitor" RELATED [ChEBI] synonym: "EC 1.5.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76733 name: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on NADH or NADPH (EC 1.6.*.*)." [] subset: 3_STAR synonym: "EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on NADH or NADPH" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on NADH or NADPH" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76736 name: EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on a heme group of donors (EC 1.9.*.*)." [] subset: 3_STAR synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitor" RELATED [ChEBI] synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.* (oxidoreductase acting on donor heme group) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.* inhibitor" RELATED [ChEBI] synonym: "EC 1.9.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76738 name: EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on peroxide as donors (EC 1.11.*.*)." [] subset: 3_STAR synonym: "EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitor" RELATED [ChEBI] synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.* inhibitor" RELATED [ChEBI] synonym: "EC 1.11.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76740 name: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases), EC 1.13.*.*." [] subset: 3_STAR synonym: "EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors" RELATED [ChEBI] synonym: "EC 1.13.* inhibitor" RELATED [ChEBI] synonym: "EC 1.13.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76741 name: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.14.*.*)." [] subset: 3_STAR synonym: "EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.* inhibitor" RELATED [ChEBI] synonym: "EC 1.14.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76759 name: EC 3.* (hydrolase) inhibitor namespace: chebi_ontology def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." [] subset: 3_STAR synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.* inhibitors" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI] synonym: "hydrolase inhibitor" RELATED [ChEBI] synonym: "hydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Hydrolase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76760 name: EC 3.1.* (ester hydrolase) inhibitor namespace: chebi_ontology def: "A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*)." [] subset: 3_STAR synonym: "EC 3.1.* (ester hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.1.* inhibitors" RELATED [ChEBI] synonym: "ester hydrolase (EC 3.1.*) inhibitor" RELATED [ChEBI] synonym: "ester hydrolase (EC 3.1.*) inhibitors" RELATED [ChEBI] synonym: "ester hydrolase inhibitor" RELATED [ChEBI] synonym: "ester hydrolase inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:76764 name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor namespace: chebi_ontology def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." [] subset: 3_STAR synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:76773 name: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*)." [] subset: 3_STAR synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitor" RELATED [ChEBI] synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.* (carboxylic ester hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.1.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor [Term] id: CHEBI:76775 name: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*)." [] subset: 3_STAR synonym: "EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.1.3.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of phosphoric monoester hydrolase" RELATED [ChEBI] synonym: "inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI] synonym: "inhibitors of phosphoric monoester hydrolase" RELATED [ChEBI] synonym: "inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase inhibitor" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase inhibitors" RELATED [ChEBI] is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor [Term] id: CHEBI:76789 name: EC 2.4.1.* (hexosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any hexosyltransferase (EC 2.4.1.*)." [] subset: 3_STAR synonym: "EC 2.4.1.* (hexosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.4.1.* inhibitors" RELATED [ChEBI] synonym: "hexosyltransferase (EC 2.4.1.*) inhibitor" RELATED [ChEBI] synonym: "hexosyltransferase (EC 2.4.1.*) inhibitors" RELATED [ChEBI] synonym: "hexosyltransferase inhibitor" RELATED [ChEBI] synonym: "hexosyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76662 ! EC 2.4.* (glycosyltransferase) inhibitor [Term] id: CHEBI:76790 name: EC 2.4.2.* (pentosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any pentosyltransferase (EC 2.4.2.*)." [] subset: 3_STAR synonym: "EC 2.4.2.* (pentosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.2.* inhibitor" RELATED [ChEBI] synonym: "EC 2.4.2.* inhibitors" RELATED [ChEBI] synonym: "pentosyltransferase (EC 2.4.2.*) inhibitor" RELATED [ChEBI] synonym: "pentosyltransferase (EC 2.4.2.*) inhibitors" RELATED [ChEBI] synonym: "pentosyltransferase inhibitor" RELATED [ChEBI] synonym: "pentosyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76662 ! EC 2.4.* (glycosyltransferase) inhibitor [Term] id: CHEBI:76807 name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." [] subset: 3_STAR synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitors" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor [Term] id: CHEBI:76808 name: EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*)." [] subset: 3_STAR synonym: "EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.2.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.2.* inhibitors" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitor" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitors" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase inhibitor" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase inhibitors" RELATED [ChEBI] is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor [Term] id: CHEBI:76812 name: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*)." [] subset: 3_STAR synonym: "EC 2.7.11.* (protein-serine/threonine kinase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.11.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.11.* inhibitors" RELATED [ChEBI] synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitor" RELATED [ChEBI] synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitors" RELATED [ChEBI] synonym: "protein-serine/threonine kinase inhibitor" RELATED [ChEBI] synonym: "protein-serine/threonine kinase inhibitors" RELATED [ChEBI] is_a: CHEBI:37699 ! protein kinase inhibitor [Term] id: CHEBI:76815 name: EC 2.7.7.* (nucleotidyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*)." [] subset: 3_STAR synonym: "EC 2.7.7.* (nucleotidyltransferase) inhibitors" RELATED [ChEBI] synonym: "inhibitor of nucleotidyltransferases" RELATED [ChEBI] synonym: "inhibitor of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI] synonym: "inhibitors of nucleotidyltransferases" RELATED [ChEBI] synonym: "inhibitors of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI] synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitor" RELATED [ChEBI] synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitors" RELATED [ChEBI] synonym: "nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "nucleotidyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:76816 name: EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with any enzyme in the EC 2.7.8.* (transferases for other substituted phosphate groups) category." [] subset: 3_STAR synonym: "EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.8.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.8.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:76830 name: EC 5.99.1.* (miscellaneous isomerase) inhibitor namespace: chebi_ontology def: "An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class." [] subset: 3_STAR synonym: "EC 5.99.1.* (miscellaneous isomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.* inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76697 ! EC 5.99.* (other isomerases) inhibitor [Term] id: CHEBI:76834 name: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor namespace: chebi_ontology def: "An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*)." [] subset: 3_STAR synonym: "EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.* inhibitor" RELATED [ChEBI] synonym: "EC 2.5.* inhibitors" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76837 name: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor namespace: chebi_ontology def: "An EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor that inhibits the action of any oxidoreductase incorporating 2 atoms of oxygen (EC 1.13.11.*)." [] subset: 3_STAR synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor" RELATED [ChEBI] synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.* inhibitor" RELATED [ChEBI] synonym: "EC 1.13.11.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76740 ! EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor [Term] id: CHEBI:76838 name: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor namespace: chebi_ontology def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*)." [] subset: 3_STAR synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor" RELATED [ChEBI] synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.* inhibitor" RELATED [ChEBI] synonym: "EC 1.14.14.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor [Term] id: CHEBI:76841 name: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor namespace: chebi_ontology def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using NADH or NADPH as one donor (EC 1.14.13.*)." [] subset: 3_STAR synonym: "EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.* inhibitor" RELATED [ChEBI] synonym: "EC 1.14.13.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor [Term] id: CHEBI:76842 name: vancomycin(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of vancomycin, obtained by deprotonation of the carboxy group and protonation of the two amino functions; major species at pH 7.3." [] subset: 3_STAR synonym: "vancomycin" RELATED [UniProt] xref: MetaCyc:CPD-12245 {source="SUBMITTER"} is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:28001 ! vancomycin property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C66H76Cl2N9O24" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/p+1/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYPYJXKWCTUITO-LYRMYLQWSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1450.26100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1448.43748" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C([O-])=O)c3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1)c(Cl)c2" xsd:string [Term] id: CHEBI:76853 name: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.2.3.*)." [] subset: 3_STAR synonym: "EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.2.3.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76727 ! EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor [Term] id: CHEBI:76857 name: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.3.1.*)." [] subset: 3_STAR synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor [Term] id: CHEBI:76861 name: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.4.3.*)." [] subset: 3_STAR synonym: "EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.4.3.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76730 ! EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor [Term] id: CHEBI:76863 name: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*)." [] subset: 3_STAR synonym: "EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.5.1.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76731 ! EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor [Term] id: CHEBI:76866 name: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using a quinone or similar as acceptor (EC 1.6.5.*)." [] subset: 3_STAR synonym: "EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.6.5.* inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76733 ! EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor [Term] id: CHEBI:76870 name: EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.9.3.*)." [] subset: 3_STAR synonym: "EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.9.3.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76736 ! EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor [Term] id: CHEBI:76878 name: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor namespace: chebi_ontology def: "An EC 2.3.* (acyltransferase) inhibitor that inhibits the action of any acyltransferase transferring groups other than amino-acyl groups (EC 2.3.1.*)." [] subset: 3_STAR synonym: "acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitor" RELATED [ChEBI] synonym: "acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.3.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76661 ! EC 2.3.* (acyltransferase) inhibitor [Term] id: CHEBI:76881 name: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*)." [] subset: 3_STAR synonym: "EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.1.* inhibitors" RELATED [ChEBI] synonym: "phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitor" RELATED [ChEBI] synonym: "phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:76895 name: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor namespace: chebi_ontology def: "An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme that catalyses transmembrane movement of substances (EC 3.6.3.*)." [] subset: 3_STAR synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor" RELATED [ChEBI] synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.6.3.* inhibitors" RELATED [ChEBI] is_a: CHEBI:73216 ! EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor [Term] id: CHEBI:76898 name: EC 1.14.14.1 (unspecific monooxygenase) inhibitor namespace: chebi_ontology def: "An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of an unspecified monooxygenase (EC 1.14.14.1)." [] subset: 3_STAR synonym: "aryl hydrocarbon hydroxylase inhibitor" RELATED [ChEBI] synonym: "aryl hydrocarbon hydroxylase inhibitors" RELATED [ChEBI] synonym: "aryl-4-monooxygenase inhibitor" RELATED [ChEBI] synonym: "aryl-4-monooxygenase inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.1 (unspecific monooxygenase) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.14.14.1 inhibitors" RELATED [ChEBI] synonym: "flavoprotein monooxygenase inhibitor" RELATED [ChEBI] synonym: "flavoprotein monooxygenase inhibitors" RELATED [ChEBI] synonym: "flavoprotein-linked monooxygenase inhibitor" RELATED [ChEBI] synonym: "flavoprotein-linked monooxygenase inhibitors" RELATED [ChEBI] synonym: "microsomal monooxygenase inhibitor" RELATED [ChEBI] synonym: "microsomal monooxygenase inhibitors" RELATED [ChEBI] synonym: "microsomal P-450 inhibitor" RELATED [ChEBI] synonym: "microsomal P-450 inhibitors" RELATED [ChEBI] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor" RELATED [ChEBI] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors" RELATED [ChEBI] synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitor" RELATED [ChEBI] synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitors" RELATED [ChEBI] synonym: "unspecific monooxygenase inhibitor" RELATED [ChEBI] synonym: "unspecific monooxygenase inhibitors" RELATED [ChEBI] synonym: "xenobiotic monooxygenase inhibitor" RELATED [ChEBI] synonym: "xenobiotic monooxygenase inhibitors" RELATED [ChEBI] is_a: CHEBI:76838 ! EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor [Term] id: CHEBI:76907 name: EC 4.2.1.* (hydro-lyases) inhibitor namespace: chebi_ontology def: "An EC 4.2.* (C-O lyase) inhibitor that interferes with the action of any hydro-lyase (EC 4.2.1.*)." [] subset: 3_STAR synonym: "EC 4.2.1.* (hydro-lyase) inhibitor" RELATED [ChEBI] synonym: "EC 4.2.1.* (hydro-lyase) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.* (hydro-lyases) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.* inhibitor" RELATED [ChEBI] synonym: "EC 4.2.1.* inhibitors" RELATED [ChEBI] synonym: "hydro-lyase (EC 4.2.1.*) inhibitor" RELATED [ChEBI] synonym: "hydro-lyase (EC 4.2.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76712 ! EC 4.2.* (C-O lyase) inhibitor [Term] id: CHEBI:76924 name: plant metabolite namespace: chebi_ontology alt_id: CHEBI:75766 alt_id: CHEBI:76925 def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." [] subset: 3_STAR synonym: "plant metabolites" RELATED [ChEBI] synonym: "plant secondary metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76932 name: pathway inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that interferes with one or more steps in a metabolic pathway." [] subset: 3_STAR synonym: "metabolic pathway inhibitor" RELATED [ChEBI] synonym: "metabolic pathway inhibitors" RELATED [ChEBI] synonym: "pathway inhibitors" RELATED [ChEBI] is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76946 name: fungal metabolite namespace: chebi_ontology alt_id: CHEBI:75765 alt_id: CHEBI:76947 def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." [] subset: 3_STAR synonym: "fungal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76964 name: Penicillium metabolite namespace: chebi_ontology alt_id: CHEBI:76205 alt_id: CHEBI:76963 def: "Any fungal metabolite produced during a metabolic reaction in Penicillium." [] subset: 3_STAR synonym: "Penicillium metabolites" RELATED [ChEBI] is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:76967 name: human xenobiotic metabolite namespace: chebi_ontology def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." [] subset: 3_STAR synonym: "human xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:76206 ! xenobiotic metabolite is_a: CHEBI:77746 ! human metabolite [Term] id: CHEBI:76969 name: bacterial metabolite namespace: chebi_ontology alt_id: CHEBI:75760 alt_id: CHEBI:76970 def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." [] subset: 3_STAR is_a: CHEBI:75787 ! prokaryotic metabolite [Term] id: CHEBI:76971 name: Escherichia coli metabolite namespace: chebi_ontology def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." [] subset: 3_STAR synonym: "E.coli metabolite" RELATED [ChEBI] synonym: "E.coli metabolites" RELATED [ChEBI] synonym: "Escherichia coli metabolites" RELATED [ChEBI] is_a: CHEBI:76969 ! bacterial metabolite [Term] id: CHEBI:77047 name: tylosin(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of tylosin, obtained by protonation of the tertiary amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "[(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-3-(dimethylazaniumyl)-beta-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "tylosin" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:17658 ! tylosin property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C46H78NO17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/p+1/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WBPYTXDJUQJLPQ-VMXQISHHSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "917.10750" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "916.52643" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)[NH+](C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\\C=C\\C(\\C)=C\\[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC" xsd:string [Term] id: CHEBI:77053 name: closantel namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections." [] subset: 3_STAR synonym: "5'-chloro-alpha(4)-(p-chlorophenyl)-alpha(4)-cyano-3,5-diiodo-2',4'-salicyloxylidide" RELATED [ChemIDplus] synonym: "closantel" RELATED INN [WHO_MedNet] synonym: "closantelum" RELATED INN [WHO_MedNet] synonym: "Flukiver" RELATED BRAND_NAME [ChEBI] synonym: "R 31,520" RELATED [ChemIDplus] synonym: "R 31520" RELATED [ChemIDplus] synonym: "rac-N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide" EXACT IUPAC_NAME [IUPAC] synonym: "Seponver" RELATED BRAND_NAME [ChEBI] xref: CAS:57808-65-8 {source="ChemIDplus"} xref: CAS:57808-65-8 {source="KEGG DRUG"} xref: KEGG:D03567 xref: Patent:BE839481 xref: Patent:US4005218 xref: PMID:21247019 {source="Europe PMC"} xref: PMID:22916226 {source="Europe PMC"} xref: PMID:23992251 {source="Europe PMC"} xref: PMID:3330516 {source="Europe PMC"} xref: PMID:4054009 {source="Europe PMC"} xref: PMID:7119989 {source="Europe PMC"} xref: PMID:7571353 {source="Europe PMC"} xref: PMID:9138034 {source="Europe PMC"} xref: Reaxys:6249214 {source="Reaxys"} is_a: CHEBI:60911 ! racemate relationship: has_part CHEBI:77056 ! (R)-closantel relationship: has_part CHEBI:77057 ! (S)-closantel relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug [Term] id: CHEBI:77054 name: N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide namespace: chebi_ontology def: "An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively." [] subset: 3_STAR synonym: "N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide" EXACT IUPAC_NAME [IUPAC] xref: LINCS:LSM-4989 xref: VSDB:1809 is_a: CHEBI:18379 ! nitrile is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:33853 ! phenols is_a: CHEBI:37142 ! organoiodine compound is_a: CHEBI:62733 ! aromatic amide is_a: CHEBI:83403 ! monochlorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H14Cl2I2N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JMPFSEBWVLAJKM-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "663.07400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "661.85217" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O" xsd:string [Term] id: CHEBI:77056 name: (R)-closantel namespace: chebi_ontology def: "An N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide that has R configuration." [] subset: 3_STAR synonym: "N-{5-chloro-4-[(R)-(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:77054 ! N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H14Cl2I2N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)/t17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JMPFSEBWVLAJKM-QGZVFWFLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "663.07400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "661.85217" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cc([C@H](C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O" xsd:string [Term] id: CHEBI:77057 name: (S)-closantel namespace: chebi_ontology def: "An N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide that has S configuration." [] subset: 3_STAR synonym: "N-{5-chloro-4-[(S)-(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:77054 ! N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H14Cl2I2N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)/t17-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JMPFSEBWVLAJKM-KRWDZBQOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "663.07400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "661.85217" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cc([C@@H](C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O" xsd:string [Term] id: CHEBI:77102 name: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using a quinone or related compound as acceptor (EC 1.3.5.*)." [] subset: 3_STAR synonym: "EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.5.* inhibitor" RELATED [ChEBI] synonym: "EC 1.3.5.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor [Term] id: CHEBI:77194 name: EC 2.7.1.33 (pantothenate kinase) inhibitor namespace: chebi_ontology def: "An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of pantothenate kinase (EC 2.7.1.33)." [] subset: 3_STAR synonym: "ATP:(R)-pantothenate 4'-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "ATP:(R)-pantothenate 4'-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "ATP:pantothenate 4'-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "ATP:pantothenate 4'-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "D-pantothenate kinase inhibitor" RELATED [ChEBI] synonym: "D-pantothenate kinase inhibitors" RELATED [ChEBI] synonym: "EC 2.7.1.33 (pantothenate kinase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.1.33 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.1.33 inhibitors" RELATED [ChEBI] synonym: "pantothenate kinase (EC 2.7.1.33) inhibitor" RELATED [ChEBI] synonym: "pantothenate kinase (EC 2.7.1.33) inhibitors" RELATED [ChEBI] synonym: "pantothenate kinase (phosphorylating) inhibitor" RELATED [ChEBI] synonym: "pantothenate kinase (phosphorylating) inhibitors" RELATED [ChEBI] synonym: "pantothenic acid kinase inhibitor" RELATED [ChEBI] synonym: "pantothenic acid kinase inhibitors" RELATED [ChEBI] xref: Wikipedia:Pantothenate_kinase is_a: CHEBI:76881 ! EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor [Term] id: CHEBI:77255 name: EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor namespace: chebi_ontology def: "An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83)." [] subset: 3_STAR synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitor" RELATED [ChEBI] synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.83 inhibitor" RELATED [ChEBI] synonym: "EC 3.4.24.83 inhibitors" RELATED [ChEBI] synonym: "lethal toxin inhibitor" RELATED [ChEBI] synonym: "lethal toxin inhibitors" RELATED [ChEBI] xref: Wikipedia:Anthrax_lethal_factor_endopeptidase is_a: CHEBI:59107 ! EC 3.4.24.* (metalloendopeptidase) inhibitor [Term] id: CHEBI:77308 name: ethylenebis(dithiocarbamate) namespace: chebi_ontology def: "A member of the class of dithiocarbamate anions resulting from the deprotonation of both of the dithiocarbamic acid moieties of ethylenebis(dithiocarbamic acid). The major species at pH 7.3." [] subset: 3_STAR synonym: "ethane-1,2-diyldicarbamodithioate" EXACT IUPAC_NAME [IUPAC] synonym: "ethylenebis(dithiocarbamic acid)(2-)" RELATED [ChEBI] is_a: CHEBI:84292 ! dithiocarbamate anions relationship: is_conjugate_base_of CHEBI:83986 ! ethylenebis(dithiocarbamic acid) property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H6N2S4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H8N2S4/c7-3(8)5-1-2-6-4(9)10/h1-2H2,(H2,5,7,8)(H2,6,9,10)/p-2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AWYFNIZYMPNGAI-UHFFFAOYSA-L" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "210.36500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "209.94248" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S-]C(=S)NCCNC([S-])=S" xsd:string [Term] id: CHEBI:7731 name: ofloxacin namespace: chebi_ontology alt_id: CHEBI:100146 def: "A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication." [] subset: 3_STAR synonym: "(+-)-ofloxacin" RELATED [ChEBI] synonym: "(3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid" RELATED [IUPAC] synonym: "DL 8280" RELATED [ChemIDplus] synonym: "DL-8280" RELATED [ChemIDplus] synonym: "Exocin" RELATED BRAND_NAME [ChEBI] synonym: "Floxin" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Gailuoxian" RELATED BRAND_NAME [DrugCentral] synonym: "HOE 280" RELATED [DrugBank] synonym: "HOE-280" RELATED [DrugBank] synonym: "Ocuflox" RELATED BRAND_NAME [ChemIDplus] synonym: "ofloxacin" RELATED INN [WHO_MedNet] synonym: "ofloxacine" RELATED INN [WHO_MedNet] synonym: "ofloxacino" RELATED INN [WHO_MedNet] synonym: "ofloxacinum" RELATED INN [WHO_MedNet] synonym: "OFLX" RELATED [KEGG_DRUG] synonym: "ORF 18489" RELATED [ChemIDplus] synonym: "Oxaldin" RELATED BRAND_NAME [ChemIDplus] synonym: "Prifloxcin" RELATED BRAND_NAME [DrugCentral] synonym: "Prifloxin" RELATED BRAND_NAME [DrugCentral] synonym: "rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid" RELATED [ChEBI] synonym: "rac-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "rac-ofloxacin" RELATED [ChEBI] synonym: "racemic ofloxacin" RELATED [ChEBI] synonym: "Tarivid" RELATED BRAND_NAME [ChemIDplus] synonym: "Visiren" RELATED BRAND_NAME [ChemIDplus] xref: CAS:82419-36-1 {source="ChemIDplus"} xref: CAS:82419-36-1 {source="KEGG COMPOUND"} xref: Drug_Central:1981 {source="DrugCentral"} xref: DrugBank:DB01165 xref: HMDB:HMDB0015296 xref: KEGG:C07321 xref: KEGG:D00453 xref: LINCS:LSM-4370 xref: MetaCyc:CPD-12843 xref: PMID:11710934 {source="Europe PMC"} xref: PMID:11903499 {source="Europe PMC"} xref: PMID:12827054 {source="Europe PMC"} xref: PMID:15008519 {source="Europe PMC"} xref: PMID:15557076 {source="Europe PMC"} xref: PMID:16669862 {source="Europe PMC"} xref: PMID:1804789 {source="Europe PMC"} xref: PMID:19646516 {source="Europe PMC"} xref: PMID:24497308 {source="Europe PMC"} xref: PMID:24550337 {source="Europe PMC"} xref: PMID:3469159 {source="Europe PMC"} xref: PMID:3546152 {source="Europe PMC"} xref: PMID:35897550 {source="Europe PMC"} xref: PMID:36004580 {source="Europe PMC"} xref: PMID:36228398 {source="Europe PMC"} xref: PMID:36268299 {source="Europe PMC"} xref: PMID:6960805 {source="Europe PMC"} xref: PMID:7884650 {source="Europe PMC"} xref: PMID:9228220 {source="Europe PMC"} xref: Reaxys:3657947 {source="Reaxys"} xref: VSDB:1898 xref: Wikipedia:Ofloxacin is_a: CHEBI:60911 ! racemate is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: has_part CHEBI:46577 ! dextrofloxacin relationship: has_part CHEBI:63598 ! levofloxacin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H20FN3O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "361.373" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "361.14378" xsd:string [Term] id: CHEBI:77315 name: spectinomycin(2+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the secondary amino groups of spectinomycin." [] subset: 3_STAR synonym: "(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-N,N',2-trimethyl-4-oxodecahydro-2H-pyrano[2,3-b][1,4]benzodioxine-6,8-diaminium" EXACT IUPAC_NAME [IUPAC] synonym: "spectinomycin dication" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:146260 ! spectinomycin(1+) relationship: is_conjugate_acid_of CHEBI:9215 ! spectinomycin property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H26N2O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/p+2/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UNFWWIHTNXNPBV-WXKVUWSESA-P" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "334.36430" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "334.17290" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@@H]1[C@H](O)[C@H]([NH2+]C)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O" xsd:string [Term] id: CHEBI:77318 name: pregnane X receptor agonist namespace: chebi_ontology def: "An agonist that selectively binds to and activates a pregnane X receptor." [] subset: 3_STAR synonym: "pregnane X receptor agonists" RELATED [ChEBI] synonym: "PXR agonist" RELATED [ChEBI] synonym: "PXR agonists" RELATED [ChEBI] xref: Wikipedia:Pregnane_X_receptor is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:77569 name: trovafloxacin(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of trovafloxacin, obtained by protonation of the primary amino group." [] subset: 3_STAR synonym: "(1R,5S,6s)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5-oxo-5,8-dihydro-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hexan-6-aminium" EXACT IUPAC_NAME [IUPAC] synonym: "trovafloxacin cation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:9763 ! trovafloxacin property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H16F3N4O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/p+1/t10-,11+,16+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WVPSKSLAZQPAKQ-CDMJZVDBSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "417.36070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "417.11690" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H]1[C@@H]2CN(C[C@H]12)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F" xsd:string [Term] id: CHEBI:77615 name: terbinafine(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of terbinafine, obtained by protonation of the amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-aminium" EXACT IUPAC_NAME [IUPAC] synonym: "terbinafine cation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:9448 ! terbinafine property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H26N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/p+1/b9-5+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DOMXUEMWDBAQBQ-WEVVVXLNSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "292.43730" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "292.20598" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+](C\\C=C\\C#CC(C)(C)C)Cc1cccc2ccccc12" xsd:string [Term] id: CHEBI:77718 name: carboxamidinium ion namespace: chebi_ontology def: "Any iminium ion resulting from the protonation of a carboxamidine." [] subset: 3_STAR synonym: "carboxamidinium ions" RELATED [ChEBI] is_a: CHEBI:35286 ! iminium ion [Term] id: CHEBI:77733 name: 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile namespace: chebi_ontology def: "A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group." [] subset: 3_STAR synonym: "2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" EXACT IUPAC_NAME [IUPAC] xref: CAS:52-53-9 {source="KEGG COMPOUND"} xref: KEGG:C07188 xref: KEGG:D02356 xref: LINCS:LSM-1298 is_a: CHEBI:18379 ! nitrile is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:46774 ! polyether is_a: CHEBI:50996 ! tertiary amino compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H38N2O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGTNSNPWRIOYBX-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "454.60160" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "454.28316" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC" xsd:string [Term] id: CHEBI:77734 name: dexverapamil namespace: chebi_ontology def: "A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil." [] subset: 3_STAR synonym: "(+)-(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(+)-(R)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile" RELATED [ChemIDplus] synonym: "(+)-(R)-verapamil" RELATED [ChEBI] synonym: "(+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(+)-3-(3,4-dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile" RELATED [ChEBI] synonym: "(+)-verapamil" RELATED [ChEBI] synonym: "(2R)-(+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" EXACT IUPAC_NAME [IUPAC] synonym: "(R)-(+)-verapamil" RELATED [ChEBI] synonym: "(R)-verapamil" RELATED [ChEBI] synonym: "dexverapamil" RELATED INN [WHO_MedNet] synonym: "dexverapamilo" RELATED INN [WHO_MedNet] synonym: "dexverapamilum" RELATED INN [WHO_MedNet] xref: CAS:38321-02-7 {source="ChemIDplus"} xref: PMID:7636539 {source="Europe PMC"} xref: PMID:8698736 {source="Europe PMC"} xref: PMID:8698738 {source="Europe PMC"} xref: PMID:8698739 {source="Europe PMC"} xref: PMID:8698740 {source="Europe PMC"} xref: PMID:8712693 {source="Europe PMC"} xref: Reaxys:3657914 {source="Reaxys"} is_a: CHEBI:77733 ! 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile relationship: is_conjugate_base_of CHEBI:77737 ! dexverapamil(1+) relationship: is_enantiomer_of CHEBI:77736 ! (S)-verapamil relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H38N2O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3/t27-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGTNSNPWRIOYBX-HHHXNRCGSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "454.60160" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "454.28316" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC" xsd:string [Term] id: CHEBI:77736 name: (S)-verapamil namespace: chebi_ontology def: "A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has S configuration." [] subset: 3_STAR synonym: "(-)-(S)-verapamil" RELATED [ChEBI] synonym: "(-)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(-)-verapamil" RELATED [ChEBI] synonym: "(2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" EXACT IUPAC_NAME [IUPAC] synonym: "(S)-(-)-verapamil" RELATED [ChEBI] xref: Reaxys:5314473 {source="Reaxys"} is_a: CHEBI:77733 ! 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile relationship: is_conjugate_base_of CHEBI:77738 ! (S)-verapamil(1+) relationship: is_enantiomer_of CHEBI:77734 ! dexverapamil property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H38N2O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3/t27-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGTNSNPWRIOYBX-MHZLTWQESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "454.60160" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "454.28316" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(CCN(C)CCC[C@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC" xsd:string [Term] id: CHEBI:77737 name: dexverapamil(1+) namespace: chebi_ontology def: "An ammonium ion resulting from the protonation of the tertiary amino group of dexverapamil." [] subset: 3_STAR synonym: "(4R)-4-cyano-4-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N,5-dimethylhexan-1-aminium" EXACT IUPAC_NAME [IUPAC] synonym: "(R)-verapamil(1+)" RELATED [ChEBI] is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:77734 ! dexverapamil relationship: is_enantiomer_of CHEBI:77738 ! (S)-verapamil(1+) property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H39N2O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3/p+1/t27-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGTNSNPWRIOYBX-HHHXNRCGSA-O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "455.60900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "455.29043" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(CC[NH+](C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC" xsd:string [Term] id: CHEBI:77738 name: (S)-verapamil(1+) namespace: chebi_ontology def: "An ammonium ion resulting from the protonation of the tertiary amino group of (S)-verapamil." [] subset: 3_STAR synonym: "(4S)-4-cyano-4-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N,5-dimethylhexan-1-aminium" EXACT IUPAC_NAME [IUPAC] synonym: "(S)-verapamil(1+)" EXACT [ChEBI] is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:77736 ! (S)-verapamil relationship: is_enantiomer_of CHEBI:77737 ! dexverapamil(1+) [Term] id: CHEBI:77745 name: EC 3.4.24.18 (meprin A) inhibitor namespace: chebi_ontology def: "An EC 3.4.24.* (metalloendopeptidase) inhibitor that inhibits the action of meprin A (EC 3.4.24.18)." [] subset: 3_STAR synonym: "EC 3.4.24.18 (meprin A) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.18 inhibitor" RELATED [ChEBI] synonym: "EC 3.4.24.18 inhibitors" RELATED [ChEBI] synonym: "endopeptidase-2 inhibitor" RELATED [ChEBI] synonym: "endopeptidase-2 inhibitors" RELATED [ChEBI] synonym: "meprin A (EC 3.4.24.18) inhibitor" RELATED [ChEBI] synonym: "meprin A (EC 3.4.24.18) inhibitors" RELATED [ChEBI] synonym: "meprin A inhibitor" RELATED [ChEBI] synonym: "meprin A inhibitors" RELATED [ChEBI] synonym: "meprin inhibitor" RELATED [ChEBI] synonym: "meprin inhibitors" RELATED [ChEBI] synonym: "meprin-a inhibitor" RELATED [ChEBI] synonym: "meprin-a inhibitors" RELATED [ChEBI] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitor" RELATED [ChEBI] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitors" RELATED [ChEBI] synonym: "PABA-peptide hydrolase inhibitor" RELATED [ChEBI] synonym: "PABA-peptide hydrolase inhibitors" RELATED [ChEBI] synonym: "PPH inhibitor" RELATED [ChEBI] synonym: "PPH inhibitors" RELATED [ChEBI] xref: Wikipedia:Meprin_A is_a: CHEBI:59107 ! EC 3.4.24.* (metalloendopeptidase) inhibitor [Term] id: CHEBI:77746 name: human metabolite namespace: chebi_ontology alt_id: CHEBI:75770 alt_id: CHEBI:77123 def: "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." [] subset: 3_STAR synonym: "H. sapiens metabolite" RELATED [ChEBI] synonym: "H. sapiens metabolites" RELATED [ChEBI] synonym: "Homo sapiens metabolite" RELATED [ChEBI] synonym: "Homo sapiens metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:77747 name: EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor namespace: chebi_ontology def: "An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of phospholipid-translocating ATPase (EC 3.6.3.1)." [] subset: 3_STAR synonym: "aminophospholipid-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "aminophospholipid-transporting ATPase inhibitors" RELATED [ChEBI] synonym: "ATP phosphohydrolase (phospholipid-flipping) inhibitor" RELATED [ChEBI] synonym: "ATP phosphohydrolase (phospholipid-flipping) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.1 inhibitor" RELATED [ChEBI] synonym: "EC 3.6.3.1 inhibitors" RELATED [ChEBI] synonym: "flippase inhibitor" RELATED [ChEBI] synonym: "flippase inhibitors" RELATED [ChEBI] synonym: "magnesium-ATPase inhibitor" RELATED [ChEBI] synonym: "magnesium-ATPase inhibitors" RELATED [ChEBI] synonym: "Mg(2)(+)-ATPase inhibitor" RELATED [ChEBI] synonym: "Mg(2)(+)-ATPase inhibitors" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase (EC 3.6.3.1) inhibitor" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase (EC 3.6.3.1) inhibitors" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase inhibitor" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase inhibitors" RELATED [ChEBI] synonym: "phospholipid-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "phospholipid-transporting ATPase inhibitors" RELATED [ChEBI] xref: Wikipedia:Phospholipid-translocating_ATPase is_a: CHEBI:76895 ! EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor [Term] id: CHEBI:77748 name: EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor namespace: chebi_ontology def: "An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44)." [] subset: 3_STAR synonym: "ATP phosphohydrolase (steroid-exporting) inhibitor" RELATED [ChEBI] synonym: "ATP phosphohydrolase (steroid-exporting) inhibitors" RELATED [ChEBI] synonym: "ATP phosphohydrolase (xenobiotic-exporting) inhibitor" RELATED [ChEBI] synonym: "ATP phosphohydrolase (xenobiotic-exporting) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.44 inhibitor" RELATED [ChEBI] synonym: "EC 3.6.3.44 inhibitors" RELATED [ChEBI] synonym: "MDR protein inhibitor" RELATED [ChEBI] synonym: "MDR protein inhibitors" RELATED [ChEBI] synonym: "multidrug-resistance protein inhibitor" RELATED [ChEBI] synonym: "multidrug-resistance protein inhibitors" RELATED [ChEBI] synonym: "P-glycoprotein inhibitor" RELATED [ChEBI] synonym: "P-glycoprotein inhibitors" RELATED [ChEBI] synonym: "PDR protein inhibitor" RELATED [ChEBI] synonym: "PDR protein inhibitors" RELATED [ChEBI] synonym: "pleiotropic-drug-resistance protein inhibitor" RELATED [ChEBI] synonym: "pleiotropic-drug-resistance protein inhibitors" RELATED [ChEBI] synonym: "steroid-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "steroid-transporting ATPase inhibitors" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitors" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase inhibitors" RELATED [ChEBI] xref: Wikipedia:Xenobiotic-transporting_ATPase is_a: CHEBI:76895 ! EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor [Term] id: CHEBI:77853 name: persistent organic pollutant namespace: chebi_ontology def: "Any environmental contaminant that is resistant to environmental degradation through photolytic, biological or chemical processes. Such substances can have significant impact on health and the environment, as they persist in the environment, bioaccumulate in animal tissue and so biomagnify in food chains." [] subset: 3_STAR synonym: "persistent organic pollutants" RELATED [ChEBI] synonym: "POP" RELATED [ChEBI] synonym: "POPs" RELATED [ChEBI] xref: Wikipedia:Persistant_organic_pollutant is_a: CHEBI:78298 ! environmental contaminant [Term] id: CHEBI:77884 name: EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor namespace: chebi_ontology def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14alpha-demethylase)." [] subset: 3_STAR synonym: "cytochrome P450 51 inhibitor" RELATED [ChEBI] synonym: "cytochrome P450 51 inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.70 inhibitor" RELATED [ChEBI] synonym: "EC 1.14.13.70 inhibitors" RELATED [ChEBI] synonym: "lanosterol 14-demethylase inhibitor" RELATED [ChEBI] synonym: "lanosterol 14-demethylase inhibitors" RELATED [ChEBI] synonym: "lanosterol 14alpha-demethylase inhibitor" RELATED [ChEBI] synonym: "lanosterol 14alpha-demethylase inhibitors" RELATED [ChEBI] synonym: "obtusufoliol 14-demethylase inhibitor" RELATED [ChEBI] synonym: "obtusufoliol 14-demethylase inhibitors" RELATED [ChEBI] synonym: "sterol 14-demethylase inhibitor" RELATED [ChEBI] synonym: "sterol 14-demethylase inhibitors" RELATED [ChEBI] synonym: "sterol 14alpha-demethylase inhibitor" RELATED [ChEBI] synonym: "sterol 14alpha-demethylase inhibitors" RELATED [ChEBI] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitor" RELATED [ChEBI] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitors" RELATED [ChEBI] xref: Wikipedia:Sterol_14-demethylase is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor is_a: CHEBI:83734 ! sterol demethylation inhibitor [Term] id: CHEBI:77906 name: minocycline zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of minocycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "(1S,4aS,11aR,12aS)-3-carbamoyl-10-(dimethylamino)-1-(dimethylazaniumyl)-4a,5,7-trihydroxy-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-2-olate" EXACT IUPAC_NAME [IUPAC] synonym: "minocycline" RELATED [UniProt] is_a: CHEBI:144644 ! a tetracycline zwitterion is_a: CHEBI:27369 ! zwitterion relationship: is_conjugate_acid_of CHEBI:71337 ! minocycline(1-) relationship: is_tautomer_of CHEBI:50694 ! minocycline property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27N3O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DYKFCLLONBREIL-KVUCHLLUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "457.47640" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "457.18490" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)c1ccc(O)c2C(=O)C3=C(O)[C@@]4(O)[C@@H](C[C@@H]3Cc12)[C@H]([NH+](C)C)C([O-])=C(C(N)=O)C4=O" xsd:string [Term] id: CHEBI:77932 name: tetracycline zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of tetracycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "(1S,4aS,11S,11aS,12aS)-3-carbamoyl-1-(dimethylazaniumyl)-4a,5,7,11-tetrahydroxy-11-methyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-2-olate" EXACT IUPAC_NAME [IUPAC] synonym: "tetracycline" RELATED [UniProt] is_a: CHEBI:144644 ! a tetracycline zwitterion is_a: CHEBI:27369 ! zwitterion relationship: is_conjugate_acid_of CHEBI:71392 ! tetracycline(1-) relationship: is_conjugate_base_of CHEBI:27902 ! tetracycline relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H24N2O8" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OFVLGDICTFRJMM-WESIUVDSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "444.43460" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "444.15327" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+](C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1[O-])C(=O)c1c(O)cccc1[C@@]3(C)O" xsd:string [Term] id: CHEBI:77941 name: EC 3.5.1.4 (amidase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." [] subset: 3_STAR synonym: "acylamidase inhibitor" RELATED [ChEBI] synonym: "acylamidase inhibitors" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitor" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitors" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [ChEBI] synonym: "amidase inhibitor" RELATED [ChEBI] synonym: "amidase inhibitors" RELATED [ChEBI] synonym: "amidohydrolase inhibitor" RELATED [ChEBI] synonym: "amidohydrolase inhibitors" RELATED [ChEBI] synonym: "deaminase inhibitor" RELATED [ChEBI] synonym: "deaminase inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitors" RELATED [ChEBI] synonym: "fatty acylamidase inhibitor" RELATED [ChEBI] synonym: "fatty acylamidase inhibitors" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitor" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Amidase is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:77981 name: vancomycin aglycone(1-) namespace: chebi_ontology def: "A peptide anion that is the conjugate base of vancomycin aglycone and the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "(1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylazaniumyl)pentanoyl]amino}-48-oxido-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate" EXACT IUPAC_NAME [IUPAC] synonym: "vancomycin aglycone" RELATED [UniProt] is_a: CHEBI:50525 ! phenolate anion is_a: CHEBI:60334 ! peptide anion relationship: is_conjugate_base_of CHEBI:47724 ! vancomycin aglycone relationship: is_conjugate_base_of CHEBI:75954 ! vancomycin aglycone zwitterion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H51Cl2N8O17" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H52Cl2N8O17/c1-19(2)10-29(57-3)47(71)62-42-44(68)21-5-8-33(27(54)12-21)79-35-14-23-15-36(46(35)70)80-34-9-6-22(13-28(34)55)45(69)43-52(76)61-41(53(77)78)26-16-24(64)17-32(66)38(26)25-11-20(4-7-31(25)65)39(49(73)63-43)60-50(74)40(23)59-48(72)30(18-37(56)67)58-51(42)75/h4-9,11-17,19,29-30,39-45,57,64-66,68-70H,10,18H2,1-3H3,(H2,56,67)(H,58,75)(H,59,72)(H,60,74)(H,61,76)(H,62,71)(H,63,73)(H,77,78)/p-1/t29-,30+,39-,40-,41+,42-,43+,44-,45-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JHIKFOISFAQTJQ-YZANBJIASA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1142.92200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1141.27547" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C([O-])=O)c3[O-])c(Cl)c2" xsd:string [Term] id: CHEBI:7809 name: oxacillin namespace: chebi_ontology def: "A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta." [] subset: 3_STAR synonym: "(2S,5R,6R)-3,3-dimethyl-6-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "(5-methyl-3-phenyl-4-isoxazolyl)penicillin" RELATED [ChemIDplus] synonym: "2,2-dimethyl-6beta-(5-methyl-3-phenyl-1,2-oxazole-4-carboxamido)penam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "5-methyl-3-phenyl-4-isoxazolyl-penicillin" RELATED [ChemIDplus] synonym: "6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanic acid" RELATED [ChEBI] synonym: "Oxacillin" EXACT [KEGG_COMPOUND] synonym: "oxazocillin" RELATED [ChemIDplus] xref: Beilstein:1093589 {source="Beilstein"} xref: CAS:66-79-5 {source="KEGG COMPOUND"} xref: CAS:66-79-5 {source="ChemIDplus"} xref: Drug_Central:2006 {source="DrugCentral"} xref: DrugBank:DB00713 xref: HMDB:HMDB0014851 xref: KEGG:C07334 xref: KEGG:D08307 xref: LINCS:LSM-6005 xref: Patent:US2996501 xref: PMID:14010809 {source="Europe PMC"} xref: PMID:20407237 {source="Europe PMC"} xref: PMID:24295979 {source="Europe PMC"} xref: PMID:24936596 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:8566082 {source="Europe PMC"} xref: Reaxys:1093589 {source="Reaxys"} xref: Wikipedia:Oxacillin is_a: CHEBI:17334 ! penicillin relationship: is_conjugate_acid_of CHEBI:52132 ! oxacillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H19N3O5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H19N3O5S/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26)/t13-,14+,17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UWYHMGVUTGAWSP-JKIFEVAISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "401.43600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "401.10454" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1ccccc1)C(O)=O" xsd:string [Term] id: CHEBI:78128 name: fatty acid anion 24:0 namespace: chebi_ontology def: "Any saturated fatty acid anion containing 24 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." [] subset: 3_STAR synonym: "fatty acid 24:0" RELATED [UniProt] is_a: CHEBI:58953 ! saturated fatty acid anion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H47O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "367.62880" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "367.35761" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string [Term] id: CHEBI:78295 name: food component namespace: chebi_ontology def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." [] subset: 3_STAR synonym: "dietary component" RELATED [ChEBI] synonym: "dietary components" RELATED [ChEBI] synonym: "food components" RELATED [ChEBI] is_a: CHEBI:52211 ! physiological role [Term] id: CHEBI:78298 name: environmental contaminant namespace: chebi_ontology def: "Any minor or unwanted substance introduced into the environment that can have undesired effects." [] subset: 3_STAR synonym: "environmental contaminants" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:78379 name: EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7)." [] subset: 3_STAR synonym: "EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.7 inhibitor" RELATED [ChEBI] synonym: "EC 2.5.1.7 inhibitors" RELATED [ChEBI] synonym: "enoylpyruvate transferase inhibitor" RELATED [ChEBI] synonym: "enoylpyruvate transferase inhibitors" RELATED [ChEBI] synonym: "MurA transferase inhibitor" RELATED [ChEBI] synonym: "MurA transferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitor" RELATED [ChEBI] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitors" RELATED [ChEBI] synonym: "pyruvate-UDP-acetylglucosamine transferase inhibitor" RELATED [ChEBI] synonym: "pyruvate-UDP-acetylglucosamine transferase inhibitors" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitor" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitors" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitor" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitors" RELATED [ChEBI] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitors" RELATED [ChEBI] xref: Wikipedia:UDP-N-acetylglucosamine_1-carboxyvinyltransferase is_a: CHEBI:76663 ! EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor [Term] id: CHEBI:78433 name: refrigerant namespace: chebi_ontology def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." [] subset: 3_STAR synonym: "refrigerants" RELATED [ChEBI] xref: Wikipedia:Refrigerant is_a: CHEBI:33232 ! application [Term] id: CHEBI:78608 name: alpha-amino acid zwitterion namespace: chebi_ontology alt_id: CHEBI:83409 def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." [] subset: 3_STAR synonym: "an alpha-amino acid" RELATED [UniProt] xref: MetaCyc:Alpha-Amino-Acids {source="SUBMITTER"} is_a: CHEBI:35238 ! amino acid zwitterion relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C([*])C([O-])=O" xsd:string [Term] id: CHEBI:78616 name: carbohydrates and carbohydrate derivatives namespace: chebi_ontology def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." [] subset: 3_STAR synonym: "carbohydrates and derivatives" RELATED [ChEBI] synonym: "carbohydrates and their derivatives" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:78675 name: fundamental metabolite namespace: chebi_ontology def: "Any metabolite produced by all living cells." [] subset: 3_STAR synonym: "essential metabolite" RELATED [ChEBI] synonym: "essential metabolites" RELATED [ChEBI] synonym: "fundamental metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:78692 name: 1-[biphenyl-4-yl(phenyl)methyl]imidazole namespace: chebi_ontology def: "A member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1." [] subset: 3_STAR synonym: "1-[biphenyl-4-yl(phenyl)methyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] xref: LINCS:LSM-5184 is_a: CHEBI:22888 ! biphenyls is_a: CHEBI:24780 ! imidazoles property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H18N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OCAPBUJLXMYKEJ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "310.39170" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "310.14700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1cn(cn1)C(c1ccccc1)c1ccc(cc1)-c1ccccc1" xsd:string [Term] id: CHEBI:78693 name: (R)-bifonazole namespace: chebi_ontology def: "A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the R-enantiomer of bifonazole." [] subset: 3_STAR synonym: "(-)-bifonazole" RELATED [ChEBI] synonym: "(R)-(-)-bifonazole" RELATED [ChEBI] synonym: "1-[(R)-biphenyl-4-yl(phenyl)methyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] xref: Reaxys:8626154 {source="Reaxys"} is_a: CHEBI:78692 ! 1-[biphenyl-4-yl(phenyl)methyl]imidazole relationship: is_enantiomer_of CHEBI:78694 ! (S)-bifonazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H18N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H/t22-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OCAPBUJLXMYKEJ-JOCHJYFZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "310.39170" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "310.14700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1cn(cn1)[C@H](c1ccccc1)c1ccc(cc1)-c1ccccc1" xsd:string [Term] id: CHEBI:78694 name: (S)-bifonazole namespace: chebi_ontology def: "A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the S-enantiomer of bifonazole." [] subset: 3_STAR synonym: "(+)-bifonazole" RELATED [ChEBI] synonym: "(S)-(+)-bifonazole" RELATED [ChEBI] synonym: "1-[(S)-biphenyl-4-yl(phenyl)methyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] xref: Reaxys:8626153 {source="Reaxys"} is_a: CHEBI:78692 ! 1-[biphenyl-4-yl(phenyl)methyl]imidazole relationship: is_enantiomer_of CHEBI:78693 ! (R)-bifonazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H18N2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H/t22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OCAPBUJLXMYKEJ-QFIPXVFZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "310.39170" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "310.14700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1cn(cn1)[C@@H](c1ccccc1)c1ccc(cc1)-c1ccccc1" xsd:string [Term] id: CHEBI:78696 name: cercosporamide namespace: chebi_ontology def: "A member of the class of dibenzofurans that is a potent broad spectrum antifungal agent isolated from the fungus Cercosporidium henningsii." [] subset: 3_STAR synonym: "(9aS)-8-acetyl-1,3,7-trihydroxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide" EXACT IUPAC_NAME [IUPAC] xref: CAS:131436-22-1 {source="ChemIDplus"} xref: Patent:CN101292039 xref: Patent:EP1914313 xref: Patent:JP2008214336 xref: Patent:KR20080033345 xref: Patent:US2010152467 xref: Patent:WO2007018194 xref: PMID:15302826 {source="Europe PMC"} xref: PMID:21814808 {source="Europe PMC"} xref: PMID:23509154 {source="Europe PMC"} xref: PMID:8289782 {source="Europe PMC"} xref: Reaxys:5485233 {source="Reaxys"} is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:38922 ! dibenzofurans is_a: CHEBI:51867 ! methyl ketone relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:38231 ! has role phytotoxin relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite relationship: RO:0000087 CHEBI:79091 ! has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H13NO7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,19-21H,1-2H3,(H2,17,23)/t16-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GEWLYFZWVLXQME-MRXNPFEDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "331.27690" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "331.06920" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)C1=C(O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O" xsd:string [Term] id: CHEBI:78787 name: dithiocarbamic acids namespace: chebi_ontology def: "Any organic acid in which both oxygens of a carbamic acid have been replaced by sulfur." [] subset: 3_STAR synonym: "dithiocarbamic acid" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:50492 ! thiocarbonyl compound is_a: CHEBI:64709 ! organic acid relationship: is_conjugate_acid_of CHEBI:84292 ! dithiocarbamate anions property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNS2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "91.158" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "90.95504" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "SC(=S)N([*])[*]" xsd:string [Term] id: CHEBI:78840 name: olefinic compound namespace: chebi_ontology def: "Any organic molecular entity that contains at least one C=C bond." [] subset: 3_STAR synonym: "olefinic compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:79020 name: alpha,beta-unsaturated monocarboxylic acid namespace: chebi_ontology def: "A monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C#C bond." [] subset: 3_STAR synonym: "2,3-unsaturated monocarboxylic acid" RELATED [ChEBI] synonym: "2,3-unsaturated monocarboxylic acids" RELATED [ChEBI] synonym: "alpha,beta-unsaturated monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid [Term] id: CHEBI:79091 name: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor namespace: chebi_ontology alt_id: CHEBI:75997 def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24)." [] subset: 3_STAR synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitor" RELATED [ChEBI] synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitors" RELATED [ChEBI] synonym: "c-Jun N-terminal kinase inhibitor" RELATED [ChEBI] synonym: "c-Jun N-terminal kinase inhibitors" RELATED [ChEBI] synonym: "Dp38 inhibitor" RELATED [ChEBI] synonym: "Dp38 inhibitors" RELATED [ChEBI] synonym: "EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.11.24 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.11.24 inhibitors" RELATED [ChEBI] synonym: "ERK inhibitor" RELATED [ChEBI] synonym: "ERK inhibitors" RELATED [ChEBI] synonym: "ERK1 inhibitor" RELATED [ChEBI] synonym: "ERK1 inhibitors" RELATED [ChEBI] synonym: "ERK2 inhibitor" RELATED [ChEBI] synonym: "ERK2 inhibitors" RELATED [ChEBI] synonym: "extracellular signal-regulated kinase inhibitor" RELATED [ChEBI] synonym: "extracellular signal-regulated kinase inhibitors" RELATED [ChEBI] synonym: "JNK inhibitor" RELATED [ChEBI] synonym: "JNK inhibitors" RELATED [ChEBI] synonym: "JNK3alpha1 inhibitor" RELATED [ChEBI] synonym: "JNK3alpha1 inhibitors" RELATED [ChEBI] synonym: "LeMPK3 inhibitor" RELATED [ChEBI] synonym: "LeMPK3 inhibitors" RELATED [ChEBI] synonym: "MAP kinase inhibitor" RELATED [ChEBI] synonym: "MAP kinase inhibitors" RELATED [ChEBI] synonym: "MAP-2 kinase inhibitor" RELATED [ChEBI] synonym: "MAP-2 kinase inhibitors" RELATED [ChEBI] synonym: "MAPK inhibitor" RELATED [ChEBI] synonym: "MAPK inhibitors" RELATED [ChEBI] synonym: "MBP kinase I inhibitor" RELATED [ChEBI] synonym: "MBP kinase I inhibitors" RELATED [ChEBI] synonym: "MBP kinase II inhibitor" RELATED [ChEBI] synonym: "MBP kinase II inhibitors" RELATED [ChEBI] synonym: "MEK inhibitor" RELATED [ChEBI] synonym: "MEK inhibitors" RELATED [ChEBI] synonym: "microtubule-associated protein 2 kinase inhibitor" RELATED [ChEBI] synonym: "microtubule-associated protein 2 kinase inhibitors" RELATED [ChEBI] synonym: "microtubule-associated protein kinase inhibitor" RELATED [ChEBI] synonym: "microtubule-associated protein kinase inhibitors" RELATED [ChEBI] synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitor" RELATED [ChEBI] synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitors" RELATED [ChEBI] synonym: "mitogen-activated protein kinase inhibitor" RELATED [ChEBI] synonym: "mitogen-activated protein kinase inhibitors" RELATED [ChEBI] synonym: "myelin basic protein kinase inhibitor" RELATED [ChEBI] synonym: "myelin basic protein kinase inhibitors" RELATED [ChEBI] synonym: "p38-2 inhibitor" RELATED [ChEBI] synonym: "p38-2 inhibitors" RELATED [ChEBI] synonym: "p38delta inhibitor" RELATED [ChEBI] synonym: "p38delta inhibitors" RELATED [ChEBI] synonym: "p42 mitogen-activated protein kinase inhibitor" RELATED [ChEBI] synonym: "p42 mitogen-activated protein kinase inhibitors" RELATED [ChEBI] synonym: "p42(mapk) inhibitor" RELATED [ChEBI] synonym: "p42(mapk) inhibitors" RELATED [ChEBI] synonym: "p44mpk inhibitor" RELATED [ChEBI] synonym: "p44mpk inhibitors" RELATED [ChEBI] synonym: "PMK-1 inhibitor" RELATED [ChEBI] synonym: "PMK-1 inhibitors" RELATED [ChEBI] synonym: "PMK-2 inhibitor" RELATED [ChEBI] synonym: "PMK-2 inhibitors" RELATED [ChEBI] synonym: "PMK-3 inhibitor" RELATED [ChEBI] synonym: "PMK-3 inhibitors" RELATED [ChEBI] synonym: "pp42 inhibitor" RELATED [ChEBI] synonym: "pp42 inhibitors" RELATED [ChEBI] synonym: "pp44(mapk) inhibitor" RELATED [ChEBI] synonym: "pp44(mapk) inhibitors" RELATED [ChEBI] synonym: "SAPK inhibitor" RELATED [ChEBI] synonym: "SAPK inhibitors" RELATED [ChEBI] synonym: "STK26 inhibitor" RELATED [ChEBI] synonym: "STK26 inhibitors" RELATED [ChEBI] synonym: "stress-activated protein kinase inhibitor" RELATED [ChEBI] synonym: "stress-activated protein kinase inhibitors" RELATED [ChEBI] xref: Wikipedia:MEK_inhibitor xref: Wikipedia:Mitogen-activated_protein_kinase is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor [Term] id: CHEBI:79092 name: EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor namespace: chebi_ontology def: "An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any such enzyme using H2O2 as acceptor and incorporating one oxygen atom of the H2O2 into the product (EC 1.11.2.*)." [] subset: 3_STAR synonym: "EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.2.* inhibitor" RELATED [ChEBI] synonym: "EC 1.11.2.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76738 ! EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor [Term] id: CHEBI:79093 name: EC 1.11.2.2 (myeloperoxidase) inhibitor namespace: chebi_ontology def: "An EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor that interferes with the action of myeloperoxidase (EC 1.11.2.2)." [] subset: 3_STAR synonym: "chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitor" RELATED [ChEBI] synonym: "chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.2.2 (myeloperoxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.2.2 inhibitor" RELATED [ChEBI] synonym: "EC 1.11.2.2 inhibitors" RELATED [ChEBI] synonym: "MPO inhibitor" RELATED [ChEBI] synonym: "MPO inhibitors" RELATED [ChEBI] synonym: "myeloperoxidase (EC 1.11.2.2) inhibitor" RELATED [ChEBI] synonym: "myeloperoxidase (EC 1.11.2.2) inhibitors" RELATED [ChEBI] synonym: "myeloperoxidase inhibitor" RELATED [ChEBI] synonym: "myeloperoxidase inhibitors" RELATED [ChEBI] synonym: "verdoperoxidase inhibitor" RELATED [ChEBI] synonym: "verdoperoxidase inhibitors" RELATED [ChEBI] xref: Wikipedia:Myeloperoxidase is_a: CHEBI:79092 ! EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor [Term] id: CHEBI:79314 name: flame retardant namespace: chebi_ontology def: "Any compound that is added to manufactured materials to inhibit, suppress, or delay the production of flames and so prevent the spread of fire." [] subset: 3_STAR synonym: "flame retardants" RELATED [ChEBI] xref: Wikipedia:Flame_retardant is_a: CHEBI:33232 ! application [Term] id: CHEBI:7934 name: paromomycin namespace: chebi_ontology alt_id: CHEBI:44703 def: "An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside" RELATED [PDBeChem] synonym: "Aminosidin" RELATED [KEGG_COMPOUND] synonym: "aminosidine" RELATED [ChemIDplus] synonym: "Catenulin" RELATED [KEGG_COMPOUND] synonym: "crestomycin" RELATED [ChemIDplus] synonym: "estomycin" RELATED [ChemIDplus] synonym: "Hydroxymycin" RELATED [KEGG_COMPOUND] synonym: "hydroxymycin" RELATED [ChemIDplus] synonym: "Monomycin A" RELATED [KEGG_COMPOUND] synonym: "Neomycin E" RELATED [KEGG_COMPOUND] synonym: "neomycin E" RELATED [ChemIDplus] synonym: "paromomicina" RELATED INN [ChemIDplus] synonym: "PAROMOMYCIN" EXACT [PDBeChem] synonym: "Paromomycin" EXACT [KEGG_COMPOUND] synonym: "paromomycin" RELATED INN [WHO_MedNet] synonym: "Paromomycin I" RELATED [KEGG_COMPOUND] synonym: "paromomycine" RELATED INN [ChemIDplus] synonym: "paromomycinum" RELATED INN [ChemIDplus] synonym: "paucimycin" RELATED [ChemIDplus] synonym: "paucimycinum" RELATED [ChemIDplus] synonym: "R 400" RELATED [ChemIDplus] synonym: "R-400" RELATED [ChEBI] synonym: "Zygomycin A1" RELATED [KEGG_COMPOUND] xref: CAS:7542-37-2 {source="ChemIDplus"} xref: CAS:7542-37-2 {source="KEGG COMPOUND"} xref: Drug_Central:2067 {source="DrugCentral"} xref: DrugBank:DB01421 xref: KEGG:C00832 xref: KEGG:D07467 xref: Patent:US2895876 xref: Patent:US2916485 xref: PDBeChem:PAR xref: PMID:18447603 {source="Europe PMC"} xref: PMID:18947845 {source="Europe PMC"} xref: PMID:8036682 {source="Europe PMC"} xref: Reaxys:72285 {source="Reaxys"} is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic relationship: has_functional_parent CHEBI:27955 ! streptamine relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H45N5O14" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UOZODPSAJZTQNH-LSWIJEOBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "615.62850" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "615.29630" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O" xsd:string [Term] id: CHEBI:79387 name: trivalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of three." [] subset: 3_STAR synonym: "trivalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:79388 name: divalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of two." [] subset: 3_STAR synonym: "divalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:79389 name: monovalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of one." [] subset: 3_STAR synonym: "monovalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:81758 name: cyproconazole namespace: chebi_ontology def: "A diastereoisomeric mixture composed of the enantiomeric pair (2R,3S)- and (2S,3R)-cyproconazole in ratio 1:1 with the enantiomeric pair (2R,3R)- and (2S,3S)-cyproconazole. A broad spectrum fungicide, it is used on cereals and other field crops used to control Septoria, rust, powdery mildew and other diseases." [] subset: 3_STAR synonym: "alpha-(4-chlorophenyl)-alpha-(1-cyclopropylethyl)-1N-1,2,4-triazole-1-ethanol" RELATED [Alan_Wood's_Pesticides] synonym: "rac-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol" EXACT IUPAC_NAME [IUPAC] xref: CAS:94361-06-5 {source="ChemIDplus"} xref: CAS:94361-06-5 {source="KEGG COMPOUND"} xref: KEGG:C18456 xref: Pesticides:cyproconazole {source="Alan Wood's Pesticides"} xref: PMID:23708404 {source="Europe PMC"} xref: PMID:24691702 {source="Europe PMC"} xref: PMID:25182419 {source="Europe PMC"} xref: Reaxys:8324780 {source="Reaxys"} is_a: CHEBI:60915 ! diastereoisomeric mixture is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: has_part CHEBI:83749 ! (2R,3S)-cyproconazole relationship: has_part CHEBI:83750 ! (2S,3S)-cyproconazole relationship: has_part CHEBI:83752 ! (2S,3R)-cyproconazole relationship: has_part CHEBI:83753 ! (2R,3R)-cyproconazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81760 name: difenoconazole namespace: chebi_ontology def: "A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms." [] subset: 3_STAR synonym: "1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] xref: CAS:119446-68-3 {source="KEGG COMPOUND"} xref: CAS:119446-68-3 {source="NIST Chemistry WebBook"} xref: CAS:119446-68-3 {source="ChemIDplus"} xref: KEGG:C18459 xref: Pesticides:difenoconazole {source="Alan Wood's Pesticides"} xref: PMID:24405376 {source="Europe PMC"} xref: PMID:25172726 {source="Europe PMC"} xref: PMID:25306325 {source="Europe PMC"} xref: PPDB:230 xref: Reaxys:9073356 {source="Reaxys"} is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H17Cl2N3O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BQYJATMQXGBDHF-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "406.26300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "405.06470" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1COC(Cn2cncn2)(O1)c1ccc(Oc2ccc(Cl)cc2)cc1Cl" xsd:string [Term] id: CHEBI:81763 name: fludioxonil namespace: chebi_ontology def: "A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria." [] subset: 3_STAR synonym: "4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile" EXACT IUPAC_NAME [IUPAC] xref: CAS:131341-86-1 {source="KEGG COMPOUND"} xref: CAS:131341-86-1 {source="ChemIDplus"} xref: CAS:131341-86-1 {source="NIST Chemistry WebBook"} xref: KEGG:C18462 xref: Pesticides:fludioxonil {source="Alan Wood's Pesticides"} xref: PMID:23052036 {source="Europe PMC"} xref: PMID:23256745 {source="Europe PMC"} xref: PMID:23436777 {source="Europe PMC"} xref: PMID:23799251 {source="Europe PMC"} xref: PMID:24423402 {source="Europe PMC"} xref: PMID:24598029 {source="Europe PMC"} xref: PMID:24635026 {source="Europe PMC"} xref: PPDB:330 xref: Reaxys:8393936 {source="Reaxys"} is_a: CHEBI:18379 ! nitrile is_a: CHEBI:26455 ! pyrroles is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38298 ! benzodioxoles relationship: RO:0000087 CHEBI:35497 ! has role androgen antagonist relationship: RO:0000087 CHEBI:63951 ! has role estrogen receptor agonist relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H6F2N2O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H6F2N2O2/c13-12(14)17-10-3-1-2-8(11(10)18-12)9-6-16-5-7(9)4-15/h1-3,5-6,16H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MUJOIMFVNIBMKC-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "248.185" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "248.03973" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC=C2C(=C1C3=CNC=C3C#N)OC(O2)(F)F" xsd:string [Term] id: CHEBI:81781 name: tebuconazole namespace: chebi_ontology alt_id: CHEBI:83566 def: "A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops." [] subset: 3_STAR synonym: "(RS)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol" RELATED [Alan_Wood's_Pesticides] synonym: "Ethyltrianol" RELATED [ChemIDplus] synonym: "Fenetrazole" RELATED [ChemIDplus] synonym: "rac-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol" EXACT IUPAC_NAME [IUPAC] synonym: "Terbuconazole" RELATED [ChemIDplus] xref: CAS:107534-96-3 {source="KEGG COMPOUND"} xref: CAS:107534-96-3 {source="ChemIDplus"} xref: KEGG:C18489 xref: Pesticides:tebuconazole {source="Alan Wood's Pesticides"} xref: PMID:24200952 {source="Europe PMC"} xref: PMID:24522828 {source="Europe PMC"} xref: PMID:24920897 {source="Europe PMC"} xref: PMID:25300182 {source="Europe PMC"} xref: Reaxys:6686475 {source="Reaxys"} xref: Wikipedia:Tebuconazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: has_part CHEBI:83780 ! (S)-tebuconazole relationship: has_part CHEBI:83781 ! (R)-tebuconazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81783 name: tricyclazole namespace: chebi_ontology def: "A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union." [] subset: 3_STAR synonym: "5-methyl-1,2,4-triazolo[3,4-b]benzothiazole" RELATED [Alan_Wood's_Pesticides] synonym: "5-methyl-striazolo-[3,4-b]benzothiazole" RELATED [ChEBI] synonym: "5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazole" EXACT IUPAC_NAME [IUPAC] synonym: "Blas-T" RELATED BRAND_NAME [ChemIDplus] synonym: "Blascide" RELATED BRAND_NAME [NIST_Chemistry_WebBook] synonym: "Pilarblas" RELATED BRAND_NAME [ChemIDplus] synonym: "Sivic" RELATED BRAND_NAME [NIST_Chemistry_WebBook] synonym: "Tizole" RELATED BRAND_NAME [ChemIDplus] synonym: "Trizole" RELATED BRAND_NAME [ChemIDplus] xref: CAS:41814-78-2 {source="KEGG COMPOUND"} xref: CAS:41814-78-2 {source="NIST Chemistry WebBook"} xref: CAS:41814-78-2 {source="Alan Wood's Pesticides"} xref: CAS:41814-78-2 {source="ChemIDplus"} xref: HMDB:HMDB0031809 xref: KEGG:C18492 xref: PDBeChem:BEA xref: Pesticides:tricyclazole {source="Alan Wood's Pesticides"} xref: PMID:10888518 {source="Europe PMC"} xref: PMID:15996714 {source="Europe PMC"} xref: PMID:18488130 {source="Europe PMC"} xref: PMID:19062069 {source="Europe PMC"} xref: PMID:22933369 {source="Europe PMC"} xref: PMID:23507498 {source="Europe PMC"} xref: PMID:23973553 {source="Europe PMC"} xref: PMID:25335466 {source="Europe PMC"} xref: PPDB:660 xref: Reaxys:980261 {source="Reaxys"} is_a: CHEBI:48908 ! triazolobenzothiazole relationship: is_conjugate_base_of CHEBI:41032 ! 5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazol-1-ium relationship: RO:0000087 CHEBI:64933 ! has role melanin synthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H7N3S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H7N3S/c1-6-3-2-4-7-8(6)12-5-10-11-9(12)13-7/h2-5H,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DQJCHOQLCLEDLL-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "189.23700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "189.03607" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cccc2sc3nncn3c12" xsd:string [Term] id: CHEBI:81822 name: boscalid namespace: chebi_ontology def: "A pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops including fruit, vegetables and ornamentals." [] subset: 3_STAR synonym: "2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide" RELATED [Alan_Wood's_Pesticides] synonym: "2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)pyridine-3-carboxamide" RELATED [Alan_Wood's_Pesticides] synonym: "2-chloro-N-(4'-chlorobiphenyl-2-yl)nicotinamide" EXACT IUPAC_NAME [IUPAC] xref: CAS:188425-85-6 {source="KEGG COMPOUND"} xref: CAS:188425-85-6 {source="ChemIDplus"} xref: KEGG:C18547 xref: Pesticides:boscalid {source="Alan Wood's Pesticides"} xref: PMID:24380616 {source="Europe PMC"} xref: PMID:24711278 {source="Europe PMC"} xref: PMID:24893153 {source="Europe PMC"} xref: PMID:24901961 {source="Europe PMC"} xref: PMID:24936710 {source="Europe PMC"} xref: PPDB:86 xref: Reaxys:10092464 {source="Reaxys"} is_a: CHEBI:22888 ! biphenyls is_a: CHEBI:25529 ! pyridinecarboxamide is_a: CHEBI:83403 ! monochlorobenzenes is_a: CHEBI:87015 ! anilide fungicide relationship: has_functional_parent CHEBI:15940 ! nicotinic acid relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:83072 ! has role EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H12Cl2N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H12Cl2N2O/c19-13-9-7-12(8-10-13)14-4-1-2-6-16(14)22-18(23)15-5-3-11-21-17(15)20/h1-11H,(H,22,23)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WYEMLYFITZORAB-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "343.20700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "342.03267" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Clc1ccc(cc1)-c1ccccc1NC(=O)c1cccnc1Cl" xsd:string [Term] id: CHEBI:81853 name: fenhexamid namespace: chebi_ontology def: "An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol." [] subset: 3_STAR synonym: "2',3'-dichloro-4'-hydroxy-1-methylcyclohexanecarboxanilide" RELATED [ChEBI] synonym: "fenhexamide" RELATED [ChEBI] synonym: "KBR 2738" RELATED [ChemIDplus] synonym: "KBR-2738" RELATED [ChEBI] synonym: "N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexane-1-carboxamide" RELATED [Alan_Wood's_Pesticides] synonym: "N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide" EXACT IUPAC_NAME [IUPAC] synonym: "Teldor" RELATED BRAND_NAME [ChemIDplus] xref: AGR:IND500627165 {source="Europe PMC"} xref: CAS:126833-17-8 {source="KEGG COMPOUND"} xref: CAS:126833-17-8 {source="ChemIDplus"} xref: KEGG:C18593 xref: Patent:EP339418 xref: Patent:US5059623 xref: Pesticides:fenhexamid {source="Alan Wood's Pesticides"} xref: PMID:17390774 {source="Europe PMC"} xref: PMID:19285148 {source="Europe PMC"} xref: PMID:22045588 {source="Europe PMC"} xref: PMID:23052036 {source="Europe PMC"} xref: PMID:23139232 {source="Europe PMC"} xref: PPDB:298 xref: Reaxys:8996658 {source="Reaxys"} is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:33853 ! phenols is_a: CHEBI:62733 ! aromatic amide is_a: CHEBI:87015 ! anilide fungicide relationship: RO:0000087 CHEBI:83316 ! has role EC 1.14.13.72 (methylsterol monooxygenase) inhibitor relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H17Cl2NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H17Cl2NO2/c1-14(7-3-2-4-8-14)13(19)17-9-5-6-10(18)12(16)11(9)15/h5-6,18H,2-4,7-8H2,1H3,(H,17,19)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VDLGAVXLJYLFDH-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "302.19600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "301.06363" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1(CCCCC1)C(=O)Nc1ccc(O)c(Cl)c1Cl" xsd:string [Term] id: CHEBI:81913 name: diniconazole namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts." [] subset: 3_STAR synonym: "(+-)-diniconazole" RELATED [ChEBI] synonym: "(betaE)-beta-[(2,4-dichlorophenyl)methylene]-alpha-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol" RELATED [Alan_Wood's_Pesticides] synonym: "(E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol" RELATED [ChemIDplus] synonym: "(RS)-diniconazole" RELATED [ChEBI] synonym: "1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol" RELATED [NIST_Chemistry_WebBook] synonym: "rac-(1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol" EXACT IUPAC_NAME [IUPAC] synonym: "rac-diniconazole" RELATED [ChEBI] synonym: "racemic diniconazole" RELATED [ChEBI] xref: CAS:83657-24-3 {source="ChemIDplus"} xref: CAS:83657-24-3 {source="NIST Chemistry WebBook"} xref: CAS:83657-24-3 {source="KEGG COMPOUND"} xref: KEGG:C18720 xref: Pesticides:diniconazole {source="Alan Wood's Pesticides"} xref: PMID:18973222 {source="Europe PMC"} xref: PMID:22579069 {source="Europe PMC"} xref: PMID:22667094 {source="Europe PMC"} xref: PMID:23056532 {source="Europe PMC"} xref: PMID:24009183 {source="Europe PMC"} xref: PMID:24009189 {source="Europe PMC"} xref: PMID:24211030 {source="Europe PMC"} xref: PPDB:247 xref: Reaxys:9202976 {source="Reaxys"} is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: has_part CHEBI:83906 ! (S)-diniconazole relationship: has_part CHEBI:83911 ! diniconazole-M relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17Cl2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "326.220" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.07487" xsd:string [Term] id: CHEBI:81917 name: fenpropidin namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-fenpropidin. A systemic fungicide, it is used for the control of foliar diseases in cereals and sugar beet." [] subset: 3_STAR synonym: "(+-)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" RELATED [ChEBI] synonym: "(RS)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" RELATED [ChEBI] synonym: "fenpropidine" RELATED [ChemIDplus] synonym: "Patrol" RELATED BRAND_NAME [ChemIDplus] synonym: "rac-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" EXACT IUPAC_NAME [IUPAC] synonym: "Ro 12-3049" RELATED [ChemIDplus] synonym: "Ro-12-3049" RELATED [NIST_Chemistry_WebBook] xref: AGR:IND91056129 {source="Europe PMC"} xref: CAS:67306-00-7 {source="KEGG COMPOUND"} xref: CAS:67306-00-7 {source="NIST Chemistry WebBook"} xref: CAS:67306-00-7 {source="ChemIDplus"} xref: KEGG:C18726 xref: Pesticides:fenpropidin {source="Alan Wood's Pesticides"} xref: PMID:22078112 {source="Europe PMC"} xref: PMID:2591378 {source="Europe PMC"} xref: PPDB:307 xref: Reaxys:1245248 {source="Reaxys"} is_a: CHEBI:60911 ! racemate relationship: has_part CHEBI:83293 ! (R)-fenpropidin relationship: has_part CHEBI:83294 ! (S)-fenpropidin relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:83319 ! has role EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "273.45610" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.24565" xsd:string [Term] id: CHEBI:81923 name: flutriafol namespace: chebi_ontology def: "A racemate comprising an equimolar mixture of (R)- and (S)-flutriafol. A systemic fungicide, it is used to control fungal diseases in cereal crops." [] subset: 3_STAR synonym: "(+-)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol" RELATED [ChEBI] synonym: "(+-)-flutriafol" RELATED [ChEBI] synonym: "(RS)-2,4'-difluoro-alpha-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol" RELATED [Alan_Wood's_Pesticides] synonym: "alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol" RELATED [Alan_Wood's_Pesticides] synonym: "PP 450" RELATED [NIST_Chemistry_WebBook] synonym: "R 152450" RELATED [NIST_Chemistry_WebBook] synonym: "rac flutriafol" RELATED [ChEBI] synonym: "rac-(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol" RELATED [Alan_Wood's_Pesticides] synonym: "rac-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol" EXACT IUPAC_NAME [IUPAC] xref: CAS:76674-21-0 {source="NIST Chemistry WebBook"} xref: CAS:76674-21-0 {source="KEGG COMPOUND"} xref: CAS:76674-21-0 {source="ChemIDplus"} xref: KEGG:C18734 xref: Patent:EP15756 xref: Pesticides:76674-21-0 {source="Alan Wood's Pesticides"} xref: Pesticides:flutriafol {source="Alan Wood's Pesticides"} xref: PMID:18178235 {source="Europe PMC"} xref: PMID:20533452 {source="Europe PMC"} xref: PMID:21740052 {source="Europe PMC"} xref: PMID:22885544 {source="Europe PMC"} xref: PMID:22983725 {source="Europe PMC"} xref: PMID:23208429 {source="Europe PMC"} xref: PMID:24611465 {source="Europe PMC"} xref: PMID:25300182 {source="Europe PMC"} xref: PMID:25376483 {source="Europe PMC"} xref: Reaxys:7141682 {source="Reaxys"} is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: has_part CHEBI:83708 ! (R)-flutriafol relationship: has_part CHEBI:83709 ! (S)-flutriafol relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H13F2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "301.29070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "301.10267" xsd:string [Term] id: CHEBI:8232 name: piperacillin namespace: chebi_ontology alt_id: CHEBI:472443 alt_id: CHEBI:475140 alt_id: CHEBI:505944 def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6beta-{(2R)-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "Piperacillin" EXACT [KEGG_COMPOUND] synonym: "piperacillin" RELATED INN [KEGG_DRUG] synonym: "Piperacillin anhydrous" RELATED [KEGG_COMPOUND] xref: Beilstein:6081140 {source="Beilstein"} xref: CAS:61477-96-1 {source="KEGG COMPOUND"} xref: CAS:61477-96-1 {source="ChemIDplus"} xref: Drug_Central:2187 {source="DrugCentral"} xref: DrugBank:DB00319 xref: KEGG:C14034 xref: KEGG:D08380 xref: LINCS:LSM-5924 xref: Patent:DE2519400 xref: Patent:US4087424 xref: PMID:1701026 {source="Europe PMC"} xref: PMID:17116662 {source="ChEMBL"} xref: PMID:17158942 {source="ChEMBL"} xref: PMID:17851079 {source="ChEMBL"} xref: PMID:25998949 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: PMID:29148816 {source="Europe PMC"} xref: PMID:7486906 {source="Europe PMC"} xref: Reaxys:6081140 {source="Reaxys"} xref: Wikipedia:Piperacillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:52433 ! piperacillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27N5O7S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27N5O7S/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34)/t13-,14-,15+,20-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IVBHGBMCVLDMKU-GXNBUGAJSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "517.55500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "517.16312" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)N1CCN(CC)C(=O)C1=O)c1ccccc1)C(O)=O" xsd:string [Term] id: CHEBI:8269 name: Pleuromutilin namespace: chebi_ontology subset: 2_STAR synonym: "Pleuromutilin" EXACT [KEGG_COMPOUND] xref: CAS:125-65-5 {source="KEGG COMPOUND"} xref: KEGG:C09169 xref: KNApSAcK:C00003473 is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:38032 ! carbotricyclic compound is_a: CHEBI:3992 ! cyclic ketone property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H34O5" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13?,14-,16+,18-,19-,20+,21-,22-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZRZNJUXESFHSIO-ZXVYJXQESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "378.503" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "378.24062" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1CC[C@@]23CCC(=O)[C@H]2[C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]3C)OC(=O)CO" xsd:string [Term] id: CHEBI:8273 name: plumbagin namespace: chebi_ontology def: "A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively." [] subset: 3_STAR synonym: "2-methyl-5-hydroxy-1,4-naphthoquinone" RELATED [ChemIDplus] synonym: "2-methyljuglone" RELATED [ChEBI] synonym: "5-hydroxy-2-methyl-1,4-naphthalenedione" RELATED [ChemIDplus] synonym: "5-hydroxy-2-methyl-1,4-naphthoquinone" RELATED [ChEBI] synonym: "5-hydroxy-2-methylnaphthalene-1,4-dione" EXACT IUPAC_NAME [IUPAC] synonym: "plumbaein" RELATED [ChEBI] synonym: "Plumbagin" EXACT [KEGG_COMPOUND] synonym: "plumbagine" RELATED [MetaCyc] synonym: "plumbagone" RELATED [ChEBI] xref: Beilstein:1870475 {source="ChemIDplus"} xref: CAS:481-42-5 {source="KEGG COMPOUND"} xref: CAS:481-42-5 {source="ChemIDplus"} xref: Gmelin:959690 {source="Gmelin"} xref: KEGG:C10387 xref: KNApSAcK:C00002852 xref: LINCS:LSM-37061 xref: MetaCyc:CPD-4461 xref: Patent:CN1473468 xref: Patent:IN183682 xref: Patent:IN191797 xref: PDBeChem:90R xref: PMID:14727919 {source="Europe PMC"} xref: PMID:14762525 {source="Europe PMC"} xref: PMID:16078700 {source="Europe PMC"} xref: PMID:16624823 {source="Europe PMC"} xref: PMID:18974148 {source="Europe PMC"} xref: PMID:19748668 {source="Europe PMC"} xref: PMID:20858709 {source="Europe PMC"} xref: PMID:21064184 {source="Europe PMC"} xref: PMID:21559086 {source="Europe PMC"} xref: PMID:21658027 {source="Europe PMC"} xref: PMID:21741707 {source="Europe PMC"} xref: Reaxys:1870475 {source="Reaxys"} xref: Wikipedia:Plumbagin is_a: CHEBI:132157 ! hydroxy-1,4-naphthoquinone is_a: CHEBI:33853 ! phenols relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:50249 ! has role anticoagulant relationship: RO:0000087 CHEBI:50847 ! has role immunological adjuvant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C11H8O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VCMMXZQDRFWYSE-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "188.182" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "188.04734" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1=CC(=O)C2=C(O)C=CC=C2C1=O" xsd:string [Term] id: CHEBI:82891 name: glucocorticoid receptor antagonist namespace: chebi_ontology def: "An antagonist that binds to and deactivates glucocorticoid receptors." [] subset: 3_STAR synonym: "glucocorticoid receptor antagonists" RELATED [ChEBI] is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:82892 name: 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole namespace: chebi_ontology def: "A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group." [] subset: 3_STAR synonym: "1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:25698 ! ether property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H14Cl4N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BYBLEWFAAKGYCD-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "416.12900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "413.98602" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1" xsd:string [Term] id: CHEBI:82894 name: (R)-miconazole namespace: chebi_ontology def: "A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration." [] subset: 3_STAR synonym: "(R)-miconazole" EXACT [UniProt] synonym: "1-[(2R)-2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] xref: Reaxys:9651217 {source="Reaxys"} is_a: CHEBI:82892 ! 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole relationship: is_enantiomer_of CHEBI:82897 ! (S)-miconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H14Cl4N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2/t18-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BYBLEWFAAKGYCD-SFHVURJKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "416.12900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "413.98602" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Clc1ccc(CO[C@@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1" xsd:string [Term] id: CHEBI:82897 name: (S)-miconazole namespace: chebi_ontology def: "A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration." [] subset: 3_STAR synonym: "(S)-miconazole" EXACT [UniProt] synonym: "1-[(2S)-2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC] xref: Reaxys:9651216 {source="Reaxys"} is_a: CHEBI:82892 ! 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole relationship: is_enantiomer_of CHEBI:82894 ! (R)-miconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H14Cl4N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2/t18-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BYBLEWFAAKGYCD-GOSISDBHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "416.12900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "413.98602" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Clc1ccc(CO[C@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1" xsd:string [Term] id: CHEBI:83039 name: crustacean metabolite namespace: chebi_ontology def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." [] subset: 3_STAR synonym: "crustacean metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:83056 name: Daphnia magna metabolite namespace: chebi_ontology def: "A Daphnia metabolite produced by the species Daphnia magna." [] subset: 3_STAR synonym: "Daphnia magna metabolites" RELATED [ChEBI] is_a: CHEBI:83057 ! Daphnia metabolite [Term] id: CHEBI:83057 name: Daphnia metabolite namespace: chebi_ontology def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" [] subset: 3_STAR synonym: "Daphnia metabolites" RELATED [ChEBI] xref: Wikipedia:Daphnia is_a: CHEBI:83039 ! crustacean metabolite [Term] id: CHEBI:83060 name: dithiocarbamate salt namespace: chebi_ontology def: "Any salt derived from a member of the class of dithiocarbamic acids by the formal replacement of the hydrogen of the dithiocarboxy group by a metal." [] subset: 3_STAR synonym: "dithiocarbamate salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt relationship: has_part CHEBI:84292 ! dithiocarbamate anions [Term] id: CHEBI:83072 name: EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor namespace: chebi_ontology def: "An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of succinate dehydrogenase (quinone), EC 1.3.5.1." [] subset: 3_STAR synonym: "complex II inhibitor" RELATED [ChEBI] synonym: "complex II inhibitors" RELATED [ChEBI] synonym: "EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitors" RELATED [ChEBI] synonym: "EC 1.3.5.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.3.5.1 inhibitors" RELATED [ChEBI] synonym: "SDH inhibitor" RELATED [ChEBI] synonym: "SDH inhibitors" RELATED [ChEBI] synonym: "succinate dehydrogenase (ubiquinone) inhibitor" RELATED [ChEBI] synonym: "succinate dehydrogenase (ubiquinone) inhibitors" RELATED [ChEBI] synonym: "succinate dehydrogenase complex inhibitor" RELATED [ChEBI] synonym: "succinate dehydrogenase complex inhibitors" RELATED [ChEBI] synonym: "succinate dehydrogenase inhibitor" RELATED [ChEBI] synonym: "succinate dehydrogenase inhibitors" RELATED [ChEBI] synonym: "succinate:quinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "succinate:quinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "succinate:ubiquinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "succinate:ubiquinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "succinic dehydrogenase inhibitor" RELATED [ChEBI] synonym: "succinic dehydrogenase inhibitors" RELATED [ChEBI] xref: Wikipedia:Succinate_dehydrogenase is_a: CHEBI:77102 ! EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor [Term] id: CHEBI:8309 name: polymyxin B1 namespace: chebi_ontology def: "A polymyxin having a (6R)-6-methyloctanoyl group at the amino terminus." [] subset: 3_STAR synonym: "4,10-anhydro{N-[(6R)-6-methyloctanoyl]-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-phenylalanyl-L-leucyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-threonine}" EXACT IUPAC_NAME [IUPAC] synonym: "polymycin B" RELATED [ChEBI] synonym: "Polymyxin B(1)" RELATED [ChEBI] synonym: "polymyxin B1" EXACT [ChEBI] xref: Beilstein:8609638 {source="Beilstein"} xref: CAS:4135-11-9 {source="ChemIDplus"} xref: PMID:13058849 {source="Europe PMC"} xref: PMID:14212410 {source="Europe PMC"} xref: PMID:1650428 {source="Europe PMC"} xref: PMID:26803416 {source="Europe PMC"} xref: Reaxys:9838039 {source="Reaxys"} is_a: CHEBI:59062 ! polymyxin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C56H98N16O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)/t32-,33-,34-,36+,37+,38+,39+,40+,41+,42+,43-,45+,46+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQVJHHACXVLGBL-GOVYWFKWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1203.47670" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1202.74993" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O" xsd:string [Term] id: CHEBI:83146 name: Daphnia tenebrosa metabolite namespace: chebi_ontology def: "A Daphnia metabolite produced by the species Daphnia tenebrosa." [] subset: 3_STAR synonym: "Daphnia tenebrosa metabolites" RELATED [ChEBI] is_a: CHEBI:83057 ! Daphnia metabolite [Term] id: CHEBI:83291 name: 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine namespace: chebi_ontology def: "A member of the class of piperidines that is N-isobutylpiperidine in which a hydrogen of one of the methyl groups is replaced by a p-tert-butylphenyl group." [] subset: 3_STAR synonym: "1-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)piperidine" RELATED [ChemIDplus] synonym: "1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:26151 ! piperidines is_a: CHEBI:32876 ! tertiary amine property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H31N/c1-16(15-20-12-6-5-7-13-20)14-17-8-10-18(11-9-17)19(2,3)4/h8-11,16H,5-7,12-15H2,1-4H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MGNFYQILYYYUBS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "273.45610" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.24565" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(CN1CCCCC1)Cc1ccc(cc1)C(C)(C)C" xsd:string [Term] id: CHEBI:83293 name: (R)-fenpropidin namespace: chebi_ontology def: "A 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine that has R configuration." [] subset: 3_STAR synonym: "1-[(2R)-3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83291 ! 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine relationship: is_enantiomer_of CHEBI:83294 ! (S)-fenpropidin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H31N/c1-16(15-20-12-6-5-7-13-20)14-17-8-10-18(11-9-17)19(2,3)4/h8-11,16H,5-7,12-15H2,1-4H3/t16-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MGNFYQILYYYUBS-MRXNPFEDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "273.45610" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.24565" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](CN1CCCCC1)Cc1ccc(cc1)C(C)(C)C" xsd:string [Term] id: CHEBI:83294 name: (S)-fenpropidin namespace: chebi_ontology def: "A 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine that has S configuration." [] subset: 3_STAR synonym: "1-[(2S)-3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83291 ! 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine relationship: is_enantiomer_of CHEBI:83293 ! (R)-fenpropidin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H31N/c1-16(15-20-12-6-5-7-13-20)14-17-8-10-18(11-9-17)19(2,3)4/h8-11,16H,5-7,12-15H2,1-4H3/t16-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MGNFYQILYYYUBS-INIZCTEOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "273.45610" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.24565" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H](CN1CCCCC1)Cc1ccc(cc1)C(C)(C)C" xsd:string [Term] id: CHEBI:83297 name: 4-dodecyl-2,6-dimethylmorpholine namespace: chebi_ontology alt_id: CHEBI:83369 def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a dodecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "(2Xi,6Xi)-2,6-dimethyl-4-dodecylmorpholine" EXACT IUPAC_NAME [IUPAC] synonym: "2,6-dimethyl-4-dodecylmorpholine" RELATED [ChemIDplus] synonym: "4-dodecyl-2,6-dimethylmorpholine" EXACT [IUPAC] synonym: "N-dodecyl-2,6-dimethylmorpholine" RELATED [ChEBI] xref: CAS:1704-28-5 {source="ChemIDplus"} xref: PPDB:1128 xref: Reaxys:123296 {source="Reaxys"} is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: has_part CHEBI:23870 ! dodecyl group relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H37NO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H37NO/c1-4-5-6-7-8-9-10-11-12-13-14-19-15-17(2)20-18(3)16-19/h17-18H,4-16H2,1-3H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SBUKOHLFHYSZNG-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "283.49250" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "283.28751" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCN1CC(C)OC(C)C1" xsd:string [Term] id: CHEBI:83316 name: EC 1.14.13.72 (methylsterol monooxygenase) inhibitor namespace: chebi_ontology def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of methylsterol monooxygenase (EC 1.14.13.72)." [] subset: 3_STAR synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitor" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitors" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitor" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitors" RELATED [ChEBI] synonym: "4-methylsterol oxidase inhibitor" RELATED [ChEBI] synonym: "4-methylsterol oxidase inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.72 (ethylsterol monooxygenase) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.72 inhibitor" RELATED [ChEBI] synonym: "EC 1.14.13.72 inhibitors" RELATED [ChEBI] synonym: "methylsterol hydroxylase inhibitor" RELATED [ChEBI] synonym: "methylsterol hydroxylase inhibitors" RELATED [ChEBI] synonym: "methylsterol monooxygenase (EC 1.14.13.72) inhibitor" RELATED [ChEBI] synonym: "methylsterol monooxygenase (EC 1.14.13.72) inhibitors" RELATED [ChEBI] synonym: "methylsterol monooxygenase inhibitor" RELATED [ChEBI] synonym: "methylsterol monooxygenase inhibitors" RELATED [ChEBI] xref: Wikipedia:Methylsterol_monooxygenase is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor [Term] id: CHEBI:83317 name: sterol biosynthesis inhibitor namespace: chebi_ontology def: "Any compound that inhibits the biosynthesis of any sterol." [] subset: 3_STAR synonym: "sterol biosynthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:83319 name: EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor namespace: chebi_ontology def: "An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of Delta(14)-sterol reductase (EC 1.3.1.70)." [] subset: 3_STAR synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitor" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitors" RELATED [ChEBI] synonym: "C-14 sterol reductase inhibitor" RELATED [ChEBI] synonym: "C-14 sterol reductase inhibitors" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase (EC 1.3.1.70) inhibitor" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase (EC 1.3.1.70) inhibitors" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase inhibitor" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.70 inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.70 inhibitors" RELATED [ChEBI] synonym: "sterol C14-reductase inhibitor" RELATED [ChEBI] synonym: "sterol C14-reductase inhibitors" RELATED [ChEBI] xref: Wikipedia:Delta14-sterol_reductase is_a: CHEBI:76857 ! EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor [Term] id: CHEBI:83365 name: 2,6-dimethyl-4-tridecylmorpholine namespace: chebi_ontology def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a tridecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "(2Xi,6Xi)-2,6-dimethyl-4-tridecylmorpholine" EXACT IUPAC_NAME [IUPAC] synonym: "N-tridecyl-2,6-dimethylmorpholine" RELATED [ChEBI] xref: CAS:24602-86-6 {source="ChemIDplus"} xref: CAS:24602-86-6 {source="Alan Wood's Pesticides"} xref: HMDB:HMDB0031810 xref: KEGG:C11285 xref: Reaxys:608429 {source="Reaxys"} is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H39NO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H39NO/c1-4-5-6-7-8-9-10-11-12-13-14-15-20-16-18(2)21-19(3)17-20/h18-19H,4-17H2,1-3H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YTOPFCCWCSOHFV-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "297.51910" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "297.30316" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCCN1CC(C)OC(C)C1" xsd:string [Term] id: CHEBI:83368 name: 2,6-dimethyl-4-undecylmorpholine namespace: chebi_ontology def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by an undecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "(2Xi,6Xi)-2,6-dimethyl-4-undecylmorpholine" EXACT IUPAC_NAME [IUPAC] synonym: "2,6-dimethyl-N-undecylmorpholine" RELATED [ChEBI] is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H35NO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H35NO/c1-4-5-6-7-8-9-10-11-12-13-18-14-16(2)19-17(3)15-18/h16-17H,4-15H2,1-3H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LVHAEMOCOJOUOD-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "269.46590" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "269.27186" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCN1CC(C)OC(C)C1" xsd:string [Term] id: CHEBI:83370 name: 2,6-dimethyl-4-tetradecylmorpholine namespace: chebi_ontology def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a tetradecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "(2Xi,6Xi)-2,6-dimethyl-4-tetradecylmorpholine" EXACT IUPAC_NAME [IUPAC] synonym: "N-tetradecyl-2,6-dimethylmorpholine" RELATED [ChEBI] xref: Reaxys:8344499 {source="Reaxys"} is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H41NO" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H41NO/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-21-17-19(2)22-20(3)18-21/h19-20H,4-18H2,1-3H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RHIAIJKBSAWEJK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "311.54560" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "311.31881" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCCCN1CC(C)OC(C)C1" xsd:string [Term] id: CHEBI:83399 name: marine xenobiotic metabolite namespace: chebi_ontology def: "Any metabolite produced by metabolism of a xenobiotic compound in marine macro- and microorganisms." [] subset: 3_STAR synonym: "marine xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:76206 ! xenobiotic metabolite is_a: CHEBI:76507 ! marine metabolite [Term] id: CHEBI:83403 name: monochlorobenzenes namespace: chebi_ontology def: "Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine." [] subset: 3_STAR is_a: CHEBI:23132 ! chlorobenzenes [Term] id: CHEBI:83414 name: alkyl sulfate(1-) namespace: chebi_ontology def: "An organosulfate oxoanion obtained by deprotonation of the sulfo group of any alkyl sulfate; major species at pH 7.3." [] subset: 3_STAR synonym: "alkyl sulfate anion" RELATED [ChEBI] synonym: "an alkyl sulfate" RELATED [UniProt] xref: MetaCyc:Organo-Sulfates {source="SUBMITTER"} is_a: CHEBI:58958 ! organosulfate oxoanion relationship: is_conjugate_base_of CHEBI:29281 ! alkyl sulfate property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "96.064" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S(=O)(=O)O[*]" xsd:string [Term] id: CHEBI:83575 name: monofluorobenzenes namespace: chebi_ontology def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying a single fluorine substitutent." [] subset: 3_STAR synonym: "monofluorobenzenes" EXACT [ChEBI] is_a: CHEBI:35496 ! fluorobenzenes [Term] id: CHEBI:83628 name: N-acylammonia namespace: chebi_ontology def: "A carboxamide obtained by the formal condensation of the carboxy group of any carboxylic acid with ammonia." [] subset: 3_STAR synonym: "a monocarboxylic acid amide" RELATED [UniProt] is_a: CHEBI:37622 ! carboxamide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NOR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.033" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.01364" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([*])=O" xsd:string [Term] id: CHEBI:83686 name: (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol namespace: chebi_ontology def: "A member of the class of pyrimidines that is pyrimidin-5-ylmethanol in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 2-chlorophenyl group while the other is replaced by a 4-chlorophenyl group." [] subset: 3_STAR synonym: "(2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol" EXACT IUPAC_NAME [IUPAC] xref: PPDB:291 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:39447 ! pyrimidines is_a: CHEBI:83403 ! monochlorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H12Cl2N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H12Cl2N2O/c18-14-7-5-12(6-8-14)17(22,13-9-20-11-21-10-13)15-3-1-2-4-16(15)19/h1-11,22H" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NHOWDZOIZKMVAI-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "331.19600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "330.03267" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(c1ccc(Cl)cc1)(c1cncnc1)c1ccccc1Cl" xsd:string [Term] id: CHEBI:83688 name: (R)-fenarimol namespace: chebi_ontology def: "A (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol that has R configuration." [] subset: 3_STAR synonym: "(R)-(2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol" EXACT IUPAC_NAME [IUPAC] xref: PMID:22955670 {source="Europe PMC"} is_a: CHEBI:83686 ! (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol relationship: is_enantiomer_of CHEBI:83689 ! (S)-fenarimol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H12Cl2N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H12Cl2N2O/c18-14-7-5-12(6-8-14)17(22,13-9-20-11-21-10-13)15-3-1-2-4-16(15)19/h1-11,22H/t17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NHOWDZOIZKMVAI-QGZVFWFLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "331.19600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "330.03267" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[C@](c1ccc(Cl)cc1)(c1cncnc1)c1ccccc1Cl" xsd:string [Term] id: CHEBI:83689 name: (S)-fenarimol namespace: chebi_ontology def: "A (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol that has S configuration." [] subset: 3_STAR synonym: "(S)-(2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol" EXACT IUPAC_NAME [IUPAC] xref: PMID:22955670 {source="Europe PMC"} is_a: CHEBI:83686 ! (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol relationship: is_enantiomer_of CHEBI:83688 ! (R)-fenarimol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H12Cl2N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H12Cl2N2O/c18-14-7-5-12(6-8-14)17(22,13-9-20-11-21-10-13)15-3-1-2-4-16(15)19/h1-11,22H/t17-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NHOWDZOIZKMVAI-KRWDZBQOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "331.19600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "330.03267" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[C@@](c1ccc(Cl)cc1)(c1cncnc1)c1ccccc1Cl" xsd:string [Term] id: CHEBI:83707 name: 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol namespace: chebi_ontology def: "A tertiary alcohol that is ethanol in which one of the hydrogens at position 1 is replaced by an p-fluorophenyl group, the other hydrogen at position 1 is replaced by a p-fluorophenyl group, and one of the hydrogens at position 2 is replaced by a 1H-1,2,4-triazol-1-yl group." [] subset: 3_STAR xref: PPDB:353 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83575 ! monofluorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H13F2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H13F2N3O/c17-13-7-5-12(6-8-13)16(22,9-21-11-19-10-20-21)14-3-1-2-4-15(14)18/h1-8,10-11,22H,9H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JWUCHKBSVLQQCO-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "301.29070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "301.10267" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(Cn1cncn1)(c1ccc(F)cc1)c1ccccc1F" xsd:string [Term] id: CHEBI:83708 name: (R)-flutriafol namespace: chebi_ontology def: "A 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol that has R configuration." [] subset: 3_STAR synonym: "(-)-flutriafol" RELATED [ChEBI] synonym: "(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol" EXACT IUPAC_NAME [IUPAC] synonym: "(R)-(-)-flutriafol" RELATED [ChEBI] xref: PMID:21740052 {source="Europe PMC"} xref: PMID:24611465 {source="Europe PMC"} xref: PMID:25300182 {source="Europe PMC"} xref: PMID:25376483 {source="Europe PMC"} xref: PPDB:3114 is_a: CHEBI:83707 ! 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol relationship: is_enantiomer_of CHEBI:83709 ! (S)-flutriafol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H13F2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H13F2N3O/c17-13-7-5-12(6-8-13)16(22,9-21-11-19-10-20-21)14-3-1-2-4-15(14)18/h1-8,10-11,22H,9H2/t16-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JWUCHKBSVLQQCO-MRXNPFEDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "301.29070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "301.10267" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[C@](Cn1cncn1)(c1ccc(F)cc1)c1ccccc1F" xsd:string [Term] id: CHEBI:83709 name: (S)-flutriafol namespace: chebi_ontology def: "A 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol that has R configuration." [] subset: 3_STAR synonym: "(+)-flutriafol" RELATED [ChEBI] synonym: "(1S)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol" EXACT IUPAC_NAME [IUPAC] synonym: "(S)-(+)-flutriafol" RELATED [ChEBI] xref: PMID:21740052 {source="Europe PMC"} xref: PMID:24611465 {source="Europe PMC"} xref: PMID:25300182 {source="Europe PMC"} xref: PMID:25376483 {source="Europe PMC"} xref: PPDB:3115 is_a: CHEBI:83707 ! 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol relationship: is_enantiomer_of CHEBI:83708 ! (R)-flutriafol property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H13F2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H13F2N3O/c17-13-7-5-12(6-8-13)16(22,9-21-11-19-10-20-21)14-3-1-2-4-15(14)18/h1-8,10-11,22H,9H2/t16-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JWUCHKBSVLQQCO-INIZCTEOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "301.29070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "301.10267" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[C@@](Cn1cncn1)(c1ccc(F)cc1)c1ccccc1F" xsd:string [Term] id: CHEBI:83732 name: 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione namespace: chebi_ontology def: "A member of the class of oxazolidinones that is 5-ethenyl-5-methyl-2,4-oxazolidinedione in which the imide hydrogen is replaced by a 3,5-dichlorophenyl group." [] subset: 3_STAR synonym: "3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione" EXACT IUPAC_NAME [IUPAC] xref: PPDB:680 is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:35356 ! dicarboximide is_a: CHEBI:55374 ! oxazolidinone is_a: CHEBI:78840 ! olefinic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9Cl2NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H9Cl2NO3/c1-3-12(2)10(16)15(11(17)18-12)9-5-7(13)4-8(14)6-9/h3-6H,1H2,2H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FSCWZHGZWWDELK-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "286.11100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "284.99595" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1(OC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1)C=C" xsd:string [Term] id: CHEBI:83733 name: (R)-vinclozolin namespace: chebi_ontology def: "A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (R)-enantiomer of vinclozolin." [] subset: 3_STAR synonym: "(5R)-3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione" EXACT IUPAC_NAME [IUPAC] xref: Reaxys:8626241 {source="Reaxys"} is_a: CHEBI:83732 ! 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione relationship: is_enantiomer_of CHEBI:83735 ! (S)-vinclozolin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9Cl2NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H9Cl2NO3/c1-3-12(2)10(16)15(11(17)18-12)9-5-7(13)4-8(14)6-9/h3-6H,1H2,2H3/t12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FSCWZHGZWWDELK-GFCCVEGCSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "286.11100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "284.99595" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@]1(OC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1)C=C" xsd:string [Term] id: CHEBI:83734 name: sterol demethylation inhibitor namespace: chebi_ontology def: "A sterol biosynthesis inhibitor that acts by inhibiting the C14 demethylation step within fungal steroid biosynthesis." [] subset: 3_STAR synonym: "sterol demethylation inhibitors" RELATED [ChEBI] is_a: CHEBI:35718 ! antifungal agent is_a: CHEBI:83317 ! sterol biosynthesis inhibitor [Term] id: CHEBI:83735 name: (S)-vinclozolin namespace: chebi_ontology def: "A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (S)-enantiomer of vinclozolin." [] subset: 3_STAR synonym: "(5S)-3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83732 ! 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione relationship: is_enantiomer_of CHEBI:83733 ! (R)-vinclozolin property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9Cl2NO3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H9Cl2NO3/c1-3-12(2)10(16)15(11(17)18-12)9-5-7(13)4-8(14)6-9/h3-6H,1H2,2H3/t12-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FSCWZHGZWWDELK-LBPRGKRZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "286.11100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "284.99595" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@]1(OC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1)C=C" xsd:string [Term] id: CHEBI:83748 name: 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol namespace: chebi_ontology def: "A tertiary alcohol that is butan-2-ol substituted by a 4-chlorophenyl group at position 2, a cyclopropyl group at position 3 and a 1H-1,2,4-triazol-1-yl group at position 1." [] subset: 3_STAR synonym: "2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol" EXACT IUPAC_NAME [IUPAC] xref: PPDB:198 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:51454 ! cyclopropanes is_a: CHEBI:83403 ! monochlorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H18ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H18ClN3O/c1-11(12-2-3-12)15(20,8-19-10-17-9-18-19)13-4-6-14(16)7-5-13/h4-7,9-12,20H,2-3,8H2,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UFNOUKDBUJZYDE-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "291.77600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "291.11384" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C1CC1)C(O)(Cn1cncn1)c1ccc(Cl)cc1" xsd:string [Term] id: CHEBI:83749 name: (2R,3S)-cyproconazole namespace: chebi_ontology def: "The (2R,3S)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR synonym: "(2R,3S)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83752 ! (2S,3R)-cyproconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H18ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H18ClN3O/c1-11(12-2-3-12)15(20,8-19-10-17-9-18-19)13-4-6-14(16)7-5-13/h4-7,9-12,20H,2-3,8H2,1H3/t11-,15+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UFNOUKDBUJZYDE-XHDPSFHLSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "291.77600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "291.11384" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](C1CC1)[C@](O)(Cn1cncn1)c1ccc(Cl)cc1" xsd:string [Term] id: CHEBI:83750 name: (2S,3S)-cyproconazole namespace: chebi_ontology def: "The (2S,3S)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR synonym: "(2S,3S)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83753 ! (2R,3R)-cyproconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H18ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H18ClN3O/c1-11(12-2-3-12)15(20,8-19-10-17-9-18-19)13-4-6-14(16)7-5-13/h4-7,9-12,20H,2-3,8H2,1H3/t11-,15-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UFNOUKDBUJZYDE-NHYWBVRUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "291.77600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "291.11384" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](C1CC1)[C@@](O)(Cn1cncn1)c1ccc(Cl)cc1" xsd:string [Term] id: CHEBI:83752 name: (2S,3R)-cyproconazole namespace: chebi_ontology def: "The (2S,3R)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR synonym: "(2S,3R)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83749 ! (2R,3S)-cyproconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H18ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H18ClN3O/c1-11(12-2-3-12)15(20,8-19-10-17-9-18-19)13-4-6-14(16)7-5-13/h4-7,9-12,20H,2-3,8H2,1H3/t11-,15+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UFNOUKDBUJZYDE-ABAIWWIYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "291.77600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "291.11384" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H](C1CC1)[C@@](O)(Cn1cncn1)c1ccc(Cl)cc1" xsd:string [Term] id: CHEBI:83753 name: (2R,3R)-cyproconazole namespace: chebi_ontology def: "The (2R,3R)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR synonym: "(2R,3R)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83750 ! (2S,3S)-cyproconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H18ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H18ClN3O/c1-11(12-2-3-12)15(20,8-19-10-17-9-18-19)13-4-6-14(16)7-5-13/h4-7,9-12,20H,2-3,8H2,1H3/t11-,15-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UFNOUKDBUJZYDE-IAQYHMDHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "291.77600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "291.11384" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H](C1CC1)[C@](O)(Cn1cncn1)c1ccc(Cl)cc1" xsd:string [Term] id: CHEBI:83758 name: 1-\{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl\}-1H-1,2,4-triazole namespace: chebi_ontology def: "An epoxide that is oxirane substituted by a 2-chlorophenyl, 4-fluorophenyl and a 1H-1,2,4-triazol-1-ylmethyl groups." [] subset: 3_STAR synonym: "1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:32955 ! epoxide is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83403 ! monochlorobenzenes is_a: CHEBI:83575 ! monofluorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H13ClFN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H13ClFN3O/c18-15-4-2-1-3-14(15)16-17(23-16,9-22-11-20-10-21-22)12-5-7-13(19)8-6-12/h1-8,10-11,16H,9H2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZMYFCFLJBGAQRS-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "329.75600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "329.07312" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Fc1ccc(cc1)C1(Cn2cncn2)OC1c1ccccc1Cl" xsd:string [Term] id: CHEBI:83759 name: (2S,3R)-epoxiconazole namespace: chebi_ontology def: "The (2S,3R)-stereoisomer of 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole." [] subset: 3_STAR synonym: "1-{[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C11229 is_a: CHEBI:83758 ! 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole relationship: is_enantiomer_of CHEBI:83761 ! (2R,3S)-epoxiconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H13ClFN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H13ClFN3O/c18-15-4-2-1-3-14(15)16-17(23-16,9-22-11-20-10-21-22)12-5-7-13(19)8-6-12/h1-8,10-11,16H,9H2/t16-,17-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZMYFCFLJBGAQRS-IAGOWNOFSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "329.75600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "329.07312" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Fc1ccc(cc1)[C@@]1(Cn2cncn2)O[C@@H]1c1ccccc1Cl" xsd:string [Term] id: CHEBI:83761 name: (2R,3S)-epoxiconazole namespace: chebi_ontology def: "The (2R,3S)-stereoisomer of 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole." [] subset: 3_STAR synonym: "1-{[(2R,3S)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:83758 ! 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole relationship: is_enantiomer_of CHEBI:83759 ! (2S,3R)-epoxiconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H13ClFN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H13ClFN3O/c18-15-4-2-1-3-14(15)16-17(23-16,9-22-11-20-10-21-22)12-5-7-13(19)8-6-12/h1-8,10-11,16H,9H2/t16-,17-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZMYFCFLJBGAQRS-IRXDYDNUSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "329.75600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "329.07312" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Fc1ccc(cc1)[C@]1(Cn2cncn2)O[C@H]1c1ccccc1Cl" xsd:string [Term] id: CHEBI:83779 name: 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol namespace: chebi_ontology def: "A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1H-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively." [] subset: 3_STAR synonym: "1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol" EXACT IUPAC_NAME [IUPAC] xref: PPDB:610 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83403 ! monochlorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H22ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H22ClN3O/c1-15(2,3)16(21,10-20-12-18-11-19-20)9-8-13-4-6-14(17)7-5-13/h4-7,11-12,21H,8-10H2,1-3H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PXMNMQRDXWABCY-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "307.81800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "307.14514" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)C(O)(CCc1ccc(Cl)cc1)Cn1cncn1" xsd:string [Term] id: CHEBI:83780 name: (S)-tebuconazole namespace: chebi_ontology def: "The (S)-enantiomer of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol." [] subset: 3_STAR synonym: "(3S)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol" EXACT IUPAC_NAME [IUPAC] xref: Reaxys:5749276 {source="Reaxys"} is_a: CHEBI:83779 ! 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol relationship: is_enantiomer_of CHEBI:83781 ! (R)-tebuconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H22ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H22ClN3O/c1-15(2,3)16(21,10-20-12-18-11-19-20)9-8-13-4-6-14(17)7-5-13/h4-7,11-12,21H,8-10H2,1-3H3/t16-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PXMNMQRDXWABCY-MRXNPFEDSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "307.81800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "307.14514" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)[C@@](O)(CCc1ccc(Cl)cc1)Cn1cncn1" xsd:string [Term] id: CHEBI:83781 name: (R)-tebuconazole namespace: chebi_ontology def: "The (R)-enantiomer of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol." [] subset: 3_STAR synonym: "(3R)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol" EXACT IUPAC_NAME [IUPAC] xref: Reaxys:5749275 {source="Reaxys"} is_a: CHEBI:83779 ! 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol relationship: is_enantiomer_of CHEBI:83780 ! (S)-tebuconazole property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H22ClN3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H22ClN3O/c1-15(2,3)16(21,10-20-12-18-11-19-20)9-8-13-4-6-14(17)7-5-13/h4-7,11-12,21H,8-10H2,1-3H3/t16-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PXMNMQRDXWABCY-INIZCTEOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "307.81800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "307.14514" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)[C@](O)(CCc1ccc(Cl)cc1)Cn1cncn1" xsd:string [Term] id: CHEBI:83811 name: proteinogenic amino acid derivative namespace: chebi_ontology def: "Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom." [] subset: 3_STAR synonym: "canonical amino acid derivative" RELATED [ChEBI] synonym: "canonical amino acid derivatives" RELATED [ChEBI] synonym: "canonical amino-acid derivative" RELATED [ChEBI] synonym: "canonical amino-acid derivatives" RELATED [ChEBI] synonym: "proteinogenic amino acid derivatives" RELATED [ChEBI] synonym: "proteinogenic amino-acid derivative" RELATED [ChEBI] synonym: "proteinogenic amino-acid derivatives" RELATED [ChEBI] is_a: CHEBI:83821 ! amino acid derivative relationship: has_functional_parent CHEBI:83813 ! proteinogenic amino acid [Term] id: CHEBI:83813 name: proteinogenic amino acid namespace: chebi_ontology def: "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." [] subset: 3_STAR synonym: "canonical amino acid" RELATED [ChEBI] synonym: "canonical amino acids" RELATED [ChEBI] synonym: "proteinogenic amino acids" RELATED [ChEBI] xref: Wikipedia:Proteinogenic_amino_acid is_a: CHEBI:33709 ! amino acid [Term] id: CHEBI:83820 name: non-proteinogenic amino acid namespace: chebi_ontology def: "Any amino-acid that is not naturally encoded in the genetic code of any organism." [] subset: 3_STAR synonym: "non-canonical amino acid" RELATED [ChEBI] synonym: "non-canonical amino acids" RELATED [ChEBI] synonym: "non-canonical amino-acid" RELATED [ChEBI] synonym: "non-canonical amino-acids" RELATED [ChEBI] synonym: "non-coded amino acid" RELATED [ChEBI] synonym: "non-coded amino acids" RELATED [ChEBI] synonym: "non-coded amino-acid" RELATED [ChEBI] synonym: "non-coded amino-acids" RELATED [ChEBI] synonym: "non-proteinogenic amino acids" RELATED [ChEBI] synonym: "non-proteinogenic amino-acid" RELATED [ChEBI] synonym: "non-proteinogenic amino-acids" RELATED [ChEBI] xref: Wikipedia:Non-proteinogenic_amino_acids is_a: CHEBI:33709 ! amino acid [Term] id: CHEBI:83821 name: amino acid derivative namespace: chebi_ontology alt_id: CHEBI:25359 def: "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues." [] subset: 3_STAR synonym: "amino acid derivatives" RELATED [ChEBI] synonym: "modified amino acids" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:83876 name: cationic sphingoid namespace: chebi_ontology def: "An organic cation obtained by protonation of the amino function of any sphingoid" [] subset: 3_STAR synonym: "cationic sphingoids" RELATED [ChEBI] synonym: "sphingoid cation" RELATED [ChEBI] synonym: "sphingoid cations" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:35785 ! sphingoid [Term] id: CHEBI:83906 name: (S)-diniconazole namespace: chebi_ontology def: "A (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the (S)-enantiomer of diniconazole." [] subset: 3_STAR synonym: "(+)-diniconazole" RELATED [ChEBI] synonym: "(1E,3S)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol" EXACT IUPAC_NAME [IUPAC] synonym: "diniconazole (+)-form" RELATED [ChemIDplus] synonym: "S-(+)-diniconazole" RELATED [ChEBI] xref: CAS:83657-19-6 {source="ChemIDplus"} xref: PMID:24009183 {source="Europe PMC"} xref: PMID:24211030 {source="Europe PMC"} xref: PMID:30401538 {source="Europe PMC"} xref: Reaxys:9634907 {source="Reaxys"} is_a: CHEBI:83909 ! (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol relationship: is_enantiomer_of CHEBI:83911 ! diniconazole-M property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17Cl2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H17Cl2N3O/c1-15(2,3)14(21)13(20-9-18-8-19-20)6-10-4-5-11(16)7-12(10)17/h4-9,14,21H,1-3H3/b13-6+/t14-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FBOUIAKEJMZPQG-YGLIYXGISA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "326.22100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.07487" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)[C@H](O)C(=C/c1ccc(Cl)cc1Cl)\\n1cncn1" xsd:string [Term] id: CHEBI:83909 name: (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol namespace: chebi_ontology def: "A member of the class of triazoles that is 4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol substituted at position 1 by a 2,4-dichlorophenyl group." [] subset: 3_STAR synonym: "(1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol" EXACT IUPAC_NAME [IUPAC] xref: PPDB:247 is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:78840 ! olefinic compound property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17Cl2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H17Cl2N3O/c1-15(2,3)14(21)13(20-9-18-8-19-20)6-10-4-5-11(16)7-12(10)17/h4-9,14,21H,1-3H3/b13-6+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FBOUIAKEJMZPQG-AWNIVKPZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "326.22100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.07487" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)C(O)C(=C/c1ccc(Cl)cc1Cl)\\n1cncn1" xsd:string [Term] id: CHEBI:83911 name: diniconazole-M namespace: chebi_ontology def: "A (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the active R-enantiomer of diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts." [] subset: 3_STAR synonym: "(-)-diniconazole" RELATED [ChEBI] synonym: "(1E,3R)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol" EXACT IUPAC_NAME [IUPAC] synonym: "(E)-(R)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol" RELATED [Alan_Wood's_Pesticides] synonym: "(R)-diniconazole" RELATED [ChEBI] synonym: "diniconazole (-)" RELATED [ChemIDplus] synonym: "R-(-)-diniconazole" RELATED [ChEBI] xref: CAS:83657-18-5 {source="ChemIDplus"} xref: Pesticides:diniconazole-m {source="Alan Wood's Pesticides"} xref: PMID:23056532 {source="Europe PMC"} xref: PMID:30401538 {source="Europe PMC"} xref: PPDB:2907 xref: Reaxys:7381524 {source="Reaxys"} is_a: CHEBI:83909 ! (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol is_a: CHEBI:87067 ! conazole fungicide relationship: is_enantiomer_of CHEBI:83906 ! (S)-diniconazole relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17Cl2N3O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H17Cl2N3O/c1-15(2,3)14(21)13(20-9-18-8-19-20)6-10-4-5-11(16)7-12(10)17/h4-9,14,21H,1-3H3/b13-6+/t14-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FBOUIAKEJMZPQG-BLXFFLACSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "326.22100" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.07487" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)[C@@H](O)C(=C/c1ccc(Cl)cc1Cl)\\n1cncn1" xsd:string [Term] id: CHEBI:83925 name: non-proteinogenic alpha-amino acid namespace: chebi_ontology def: "Any alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." [] subset: 3_STAR synonym: "non-proteinogenic alpha-amino acids" RELATED [ChEBI] synonym: "non-proteinogenic alpha-amino-acid" RELATED [ChEBI] synonym: "non-proteinogenic alpha-amino-acids" RELATED [ChEBI] is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:83820 ! non-proteinogenic amino acid [Term] id: CHEBI:83955 name: 2-saturated fatty acid anion namespace: chebi_ontology def: "A fatty acid anion obtained by deprotonation of the carboxy group of any 2-saturated fatty acid." [] subset: 3_STAR synonym: "1,2-saturated fatty acid anion" RELATED [ChEBI] synonym: "a 1,2-saturated fatty acid" RELATED [UniProt] is_a: CHEBI:28868 ! fatty acid anion property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H2O2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "58.036" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "58.00548" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)C[*]" xsd:string [Term] id: CHEBI:83986 name: ethylenebis(dithiocarbamic acid) namespace: chebi_ontology def: "A dithiocarbamic acid resulting from the formal addition of a molecule of carbon disulfide to each amino group of ethylenediamine." [] subset: 3_STAR synonym: "ethane-1,2-diyldicarbamodithioic acid" EXACT IUPAC_NAME [IUPAC] synonym: "ethylenebisdithiocarbamic acid" RELATED [ChemIDplus] synonym: "N,N'-(ethylene)bisdithiocarbamic acid" RELATED [ChEBI] synonym: "N,N'-ethanediylbis(dithiocarbamic acid)" RELATED [ChEBI] xref: CAS:111-54-6 {source="ChemIDplus"} xref: Reaxys:1772091 {source="Reaxys"} is_a: CHEBI:78787 ! dithiocarbamic acids relationship: has_functional_parent CHEBI:30347 ! ethylenediamine relationship: is_conjugate_acid_of CHEBI:77308 ! ethylenebis(dithiocarbamate) property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H8N2S4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H8N2S4/c7-3(8)5-1-2-6-4(9)10/h1-2H2,(H2,5,7,8)(H2,6,9,10)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AWYFNIZYMPNGAI-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "212.38000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "211.95703" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "SC(=S)NCCNC(S)=S" xsd:string [Term] id: CHEBI:84002 name: 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one namespace: chebi_ontology def: "A member of the class of triazoles that is 1-hydroxy-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one in which the hydroxyl hydrogen is replaced by a 4-chlorophenyl group." [] subset: 3_STAR synonym: "1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one" EXACT IUPAC_NAME [IUPAC] xref: LINCS:LSM-4424 xref: PPDB:648 is_a: CHEBI:141498 ! hemiaminal ether is_a: CHEBI:17087 ! ketone is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83403 ! monochlorobenzenes property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H16ClN3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WURBVZBTWMNKQT-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "293.74900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "293.09310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1cncn1" xsd:string [Term] id: CHEBI:84003 name: (R)-triadimefon namespace: chebi_ontology def: "A 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one that is the (R)-enantiomer of triadimefon." [] subset: 3_STAR synonym: "(1R)-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one" EXACT IUPAC_NAME [IUPAC] xref: CAS:73804-20-3 {source="ChemIDplus"} xref: Reaxys:20863307 {source="Reaxys"} is_a: CHEBI:84002 ! 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one relationship: is_enantiomer_of CHEBI:84004 ! (S)-triadimefon property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H16ClN3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3/t13-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WURBVZBTWMNKQT-CYBMUJFWSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "293.74900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "293.09310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)C(=O)[C@@H](Oc1ccc(Cl)cc1)n1cncn1" xsd:string [Term] id: CHEBI:84004 name: (S)-triadimefon namespace: chebi_ontology def: "A 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one that is the (S)-enantiomer of triadimefon." [] subset: 3_STAR synonym: "(1S)-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one" EXACT IUPAC_NAME [IUPAC] xref: CAS:89497-67-6 {source="ChemIDplus"} xref: Reaxys:20863308 {source="Reaxys"} is_a: CHEBI:84002 ! 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one relationship: is_enantiomer_of CHEBI:84003 ! (R)-triadimefon property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H16ClN3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3/t13-/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WURBVZBTWMNKQT-ZDUSSCGKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "293.74900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "293.09310" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)C(=O)[C@H](Oc1ccc(Cl)cc1)n1cncn1" xsd:string [Term] id: CHEBI:84055 name: pentose phosphate namespace: chebi_ontology def: "Any phospho sugar that is the phosphate derivative of pentose." [] subset: 3_STAR synonym: "pentose phosphates" RELATED [ChEBI] is_a: CHEBI:33447 ! phospho sugar is_a: CHEBI:63409 ! pentose derivative [Term] id: CHEBI:84087 name: human urinary metabolite namespace: chebi_ontology def: "Any metabolite (endogenous or exogenous) found in human urine samples." [] subset: 3_STAR synonym: "human urinary metabolites" RELATED [ChEBI] is_a: CHEBI:77746 ! human metabolite [Term] id: CHEBI:84186 name: L-proline derivative namespace: chebi_ontology def: "A proteinogenic amino acid derivative resulting from reaction of L-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of L-proline by a heteroatom." [] subset: 3_STAR synonym: "L-proline derivatives" RELATED [ChEBI] is_a: CHEBI:26273 ! proline derivative is_a: CHEBI:83811 ! proteinogenic amino acid derivative relationship: has_functional_parent CHEBI:17203 ! L-proline [Term] id: CHEBI:84264 name: EC 3.5.1.19 (nicotinamidase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of nicotinamidase (EC 3.5.1.19)." [] subset: 3_STAR synonym: "EC 3.5.1.19 (nicotinamidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.19 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.19 inhibitors" RELATED [ChEBI] synonym: "nicotinamidase (EC 3.5.1.19) inhibitor" RELATED [ChEBI] synonym: "nicotinamidase (EC 3.5.1.19) inhibitors" RELATED [ChEBI] synonym: "nicotinamidase inhibitor" RELATED [ChEBI] synonym: "nicotinamidase inhibitors" RELATED [ChEBI] synonym: "nicotinamide amidase inhibitor" RELATED [ChEBI] synonym: "nicotinamide amidase inhibitors" RELATED [ChEBI] synonym: "nicotinamide amidohydrolase inhibitor" RELATED [ChEBI] synonym: "nicotinamide amidohydrolase inhibitors" RELATED [ChEBI] synonym: "nicotinamide deaminase inhibitor" RELATED [ChEBI] synonym: "nicotinamide deaminase inhibitors" RELATED [ChEBI] synonym: "YNDase inhibitor" RELATED [ChEBI] synonym: "YNDase inhibitors" RELATED [ChEBI] xref: Wikipedia:Nicotinamidase is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:84291 name: organic sulfur anion namespace: chebi_ontology def: "An organic anion in which the charge resides on a sulfur atom." [] subset: 3_STAR synonym: "organic sulfur anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:84292 name: dithiocarbamate anions namespace: chebi_ontology def: "Any organic sulfur anion resulting from the removal of a proton from any N-substituted dithiocarbamic acid." [] subset: 3_STAR is_a: CHEBI:84291 ! organic sulfur anion relationship: is_conjugate_base_of CHEBI:78787 ! dithiocarbamic acids property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CNS2R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "90.14800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.94722" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S-]C(=S)N([*])[*]" xsd:string [Term] id: CHEBI:8434 name: prochloraz namespace: chebi_ontology def: "A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables." [] subset: 3_STAR synonym: "N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide" EXACT IUPAC_NAME [IUPAC] xref: CAS:67747-09-5 {source="KEGG COMPOUND"} xref: CAS:67747-09-5 {source="ChemIDplus"} xref: KEGG:C11182 xref: Pesticides:prochloraz {source="Alan Wood's Pesticides"} xref: PMID:24401010 {source="Europe PMC"} xref: PMID:24964350 {source="Europe PMC"} xref: PMID:25163568 {source="Europe PMC"} xref: PPDB:536 xref: Reaxys:8155344 {source="Reaxys"} is_a: CHEBI:27096 ! trichlorobenzene is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:47857 ! ureas is_a: CHEBI:60600 ! amide fungicide is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87068 ! imidazole fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H16Cl3N3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H16Cl3N3O2/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18/h3,5,8-10H,2,4,6-7H2,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TVLSRXXIMLFWEO-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "376.66500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "375.03081" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCN(CCOc1c(Cl)cc(Cl)cc1Cl)C(=O)n1ccnc1" xsd:string [Term] id: CHEBI:84735 name: algal metabolite namespace: chebi_ontology def: "Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae." [] subset: 3_STAR synonym: "algal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:84739 name: amikacin(4+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the four free amino groups of amikacin; major species at pH 7.3." [] subset: 3_STAR synonym: "(1S,2S,3R,4S,6R)-4-azaniumyl-3-[(6-azaniumyl-6-deoxy-alpha-D-glucopyranosyl)oxy]-6-{[(2S)-4-azaniumyl-2-hydroxybutanoyl]amino}-2-hydroxycyclohexyl 3-azaniumyl-3-deoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:2637 ! amikacin property_value: http://purl.obolibrary.org/obo/chebi/charge "+4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H47N5O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/p+4/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LKCWBDHBTVXHDL-RMDFUYIESA-R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "589.63210" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "589.31484" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]CC[C@H](O)C(=O)N[C@@H]1C[C@H]([NH3+])[C@@H](O[C@H]2O[C@H](C[NH3+])[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H]([NH3+])[C@H]1O" xsd:string [Term] id: CHEBI:8489 name: propiconazole namespace: chebi_ontology alt_id: CHEBI:658576 def: "The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds." [] subset: 3_STAR synonym: "(+-)-1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole" RELATED [ChEBI] synonym: "1-{[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole" EXACT IUPAC_NAME [IUPAC] synonym: "Propiconazole" EXACT [KEGG_COMPOUND] xref: CAS:60207-90-1 {source="KEGG COMPOUND"} xref: CAS:60207-90-1 {source="ChemIDplus"} xref: CAS:75881-82-2 {source="NIST Chemistry WebBook"} xref: KEGG:C11121 xref: MetaCyc:CPD-14540 xref: Patent:DE2551560 xref: Patent:US4079062 xref: Pesticides:propiconazole {source="Alan Wood's Pesticides"} xref: PMID:19128860 {source="ChEMBL"} xref: PPDB:551 xref: Reaxys:841361 {source="Reaxys"} xref: Wikipedia:Propiconazole is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H17Cl2N3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "STJLVHWMYQXCPB-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "342.22000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "341.06978" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCC1COC(Cn2cncn2)(O1)c1ccc(Cl)cc1Cl" xsd:string [Term] id: CHEBI:85251 name: teicoplanin A2-2 namespace: chebi_ontology def: "A teicoplanin A2 that has 8-methylnonanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((8-methyl-1-oxononyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(8-methyl-1-oxononyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "teichomycin A2 factor 2" RELATED [ChemIDplus] synonym: "teicoplanin A2-2" EXACT [ChemIDplus] xref: CAS:91032-26-7 {source="ChemIDplus"} xref: Patent:US4542018 xref: PMID:11833531 {source="Europe PMC"} xref: PMID:25095906 {source="Europe PMC"} xref: PMID:25147913 {source="Europe PMC"} xref: Reaxys:7508820 {source="Reaxys"} is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C88H97Cl2N9O33" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C88H97Cl2N9O33/c1-33(2)8-6-4-5-7-9-60(108)94-68-74(113)71(110)58(31-101)129-87(68)132-78-55-25-40-26-56(78)126-52-17-13-38(23-47(52)90)77(131-86-67(92-34(3)103)73(112)70(109)57(30-100)128-86)69-84(121)98-66(85(122)123)45-28-42(105)29-54(127-88-76(115)75(114)72(111)59(32-102)130-88)61(45)44-22-37(12-14-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-20-41(104)27-43(21-39)124-53-24-36(11-15-50(53)107)62(91)80(117)93-48(79(116)95-64)19-35-10-16-51(125-55)46(89)18-35/h10-18,20-29,33,48,57-59,62-77,86-88,100-102,104-107,109-115H,4-9,19,30-32,91H2,1-3H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/t48-,57-,58-,59-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71-,72-,73-,74-,75+,76+,77-,86+,87+,88+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GHOXVFYORXUCPY-PKMGYIMSSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1879.65800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1877.55658" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)CCCCCCC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1Oc1c2Oc3ccc(C[C@H]4NC(=O)[C@H](N)c5ccc(O)c(Oc6cc(O)cc(c6)[C@H](NC4=O)C(=O)N[C@@H]4c(c2)cc1Oc1ccc(cc1Cl)[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)[C@@H]1NC(=O)[C@H](NC4=O)c2ccc(O)c(c2)-c2c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)cc(O)cc2[C@H](NC1=O)C(O)=O)c5)cc3Cl" xsd:string [Term] id: CHEBI:86323 name: conazole antifungal agent namespace: chebi_ontology alt_id: CHEBI:60593 def: "A compound that has a structure that is related to miconazole, contains an azole (imidazole or triazole) moiety, and has significant systemic antifungal properties. They inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function." [] subset: 3_STAR synonym: "azole antibiotic" RELATED [ChEBI] synonym: "azole antibiotics" RELATED [ChEBI] synonym: "conazole antifungal agents" RELATED [ChEBI] is_a: CHEBI:68452 ! azole relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:75282 ! has role ergosterol biosynthesis inhibitor [Term] id: CHEBI:86324 name: quinolone antibiotic namespace: chebi_ontology def: "An organonitrogen heterocyclic antibiotic whose structure contains a quinolone or quinolone-related skeleton." [] subset: 3_STAR synonym: "quinolone antibiotics" RELATED [ChEBI] is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic [Term] id: CHEBI:86327 name: antifungal drug namespace: chebi_ontology def: "Any antifungal agent used to prevent or treat fungal infections in humans or animals." [] subset: 3_STAR synonym: "anti-fungal drug" RELATED [ChEBI] synonym: "anti-fungal drugs" RELATED [ChEBI] synonym: "anti-fungal medication" RELATED [ChEBI] synonym: "anti-fungal medications" RELATED [ChEBI] synonym: "antifungal drugs" RELATED [ChEBI] synonym: "antifungal medication" RELATED [ChEBI] synonym: "antifungal medications" RELATED [ChEBI] synonym: "pharmaceutical fungicide" RELATED [ChEBI] synonym: "pharmaceutical fungicides" RELATED [ChEBI] xref: Wikipedia:Antifungal is_a: CHEBI:35441 ! antiinfective agent is_a: CHEBI:35718 ! antifungal agent [Term] id: CHEBI:86328 name: antifungal agrochemical namespace: chebi_ontology def: "Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties." [] subset: 3_STAR synonym: "agrichemical fungicide" RELATED [ChEBI] synonym: "agrichemical fungicides" RELATED [ChEBI] synonym: "agrochemical fungicide" RELATED [ChEBI] synonym: "agrochemical fungicides" RELATED [ChEBI] synonym: "anti-fungal agrichemical" RELATED [ChEBI] synonym: "anti-fungal agrichemicals" RELATED [ChEBI] synonym: "anti-fungal agrochemical" RELATED [ChEBI] synonym: "anti-fungal agrochemicals" RELATED [ChEBI] synonym: "antifungal agrichemical" RELATED [ChEBI] synonym: "antifungal agrichemicals" RELATED [ChEBI] synonym: "antifungal agrochemicals" RELATED [ChEBI] is_a: CHEBI:24127 ! fungicide is_a: CHEBI:33286 ! agrochemical [Term] id: CHEBI:86411 name: cis-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine namespace: chebi_ontology def: "Either of the two diastereoisomers of 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine in which the imidazol-1-ylmethyl group and the aryloxymethyl group are in a cis relationship to each other - i.e. they are both on the same side of the plane of the dioxolane ring. The antifungal drug ketoconazole is a racemic mixture of the two cis diastereoisomers." [] subset: 3_STAR is_a: CHEBI:48339 ! 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine [Term] id: CHEBI:86420 name: imidazole antifungal agent namespace: chebi_ontology def: "A compound that has significant antifungal properties whose structure contains an imidazole moiety." [] subset: 3_STAR synonym: "imidazole antifungal agents" RELATED [ChEBI] is_a: CHEBI:24780 ! imidazoles relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:86426 name: triazole antifungal agent namespace: chebi_ontology def: "A member of the class of triazole that has significant antifungal properties." [] subset: 3_STAR synonym: "triazole antifungal agents" RELATED [ChEBI] is_a: CHEBI:35727 ! triazoles relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:86478 name: antibiotic antifungal agent namespace: chebi_ontology def: "Heteroorganic entities that are microbial metabolites (or compounds derived from them) which have significant antifungal properties." [] subset: 3_STAR synonym: "antibiotic antifungal agents" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:86482 name: strobilurin antifungal agent namespace: chebi_ontology def: "Any antibiotic antifungal agents whose structure is based on the antifungal agents originally isolated from the fungus Strobilurus tenacellus." [] subset: 3_STAR synonym: "strobilurin antifungal agents" RELATED [ChEBI] xref: Wikipedia:Strobilurin is_a: CHEBI:86478 ! antibiotic antifungal agent [Term] id: CHEBI:86484 name: methoxyacrylate strobilurin antifungal agent namespace: chebi_ontology def: "Any strobilurin antifungal agent that contains a methoxyacrylate group." [] subset: 3_STAR synonym: "methoxyacrylate strobilurin antifungal agents" RELATED [ChEBI] is_a: CHEBI:25248 ! methyl ester is_a: CHEBI:51702 ! enoate ester is_a: CHEBI:86482 ! strobilurin antifungal agent [Term] id: CHEBI:8653 name: pyocyanine namespace: chebi_ontology alt_id: CHEBI:137500 def: "An iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. An antibiotic pigment produced by Pseudomonas aeruginosa." [] subset: 3_STAR synonym: "5-methylphenazin-5-ium-1-olate" EXACT IUPAC_NAME [IUPAC] synonym: "pyocyanin" RELATED [ChEBI] xref: CAS:85-66-5 {source="ChemIDplus"} xref: CAS:85-66-5 {source="KEGG COMPOUND"} xref: Chemspider:6558 xref: KEGG:C01748 xref: MetaCyc:CPD-12847 xref: PDBeChem:3J8 xref: PMID:21888766 {source="Europe PMC"} xref: PMID:27322205 {source="Europe PMC"} xref: PMID:27517959 {source="Europe PMC"} xref: PMID:27559393 {source="Europe PMC"} xref: PMID:27940577 {source="Europe PMC"} xref: PMID:28333255 {source="Europe PMC"} xref: PMID:28408162 {source="Europe PMC"} xref: PMID:28558232 {source="Europe PMC"} xref: PMID:28607159 {source="Europe PMC"} xref: PMID:31647218 {source="Europe PMC"} xref: PMID:31981486 {source="Europe PMC"} xref: PMID:32417365 {source="Europe PMC"} xref: PMID:32707314 {source="Europe PMC"} xref: PMID:32763156 {source="Europe PMC"} xref: PMID:33398400 {source="Europe PMC"} xref: PMID:33545813 {source="Europe PMC"} xref: PMID:33578646 {source="Europe PMC"} xref: Reaxys:11862 {source="Reaxys"} xref: Wikipedia:Pyocyanin is_a: CHEBI:35285 ! iminium betaine is_a: CHEBI:39201 ! phenazines relationship: is_conjugate_base_of CHEBI:62220 ! pyocyanine(1+) relationship: RO:0000087 CHEBI:26130 ! has role biological pigment relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:72316 ! has role virulence factor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H10N2O" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YNCMLFHHXWETLD-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "210.236" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "210.07931" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[N+]1=C2C=CC=CC2=NC2=C1C=CC=C2[O-]" xsd:string [Term] id: CHEBI:8674 name: pyrimethanil namespace: chebi_ontology def: "A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6. A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control Botrytis cinerea throughout the winemaking process in grapes, must, fermenting must and wine." [] subset: 3_STAR synonym: "2-Anilino-4,6-dimethylpyrimidine" RELATED [HMDB] synonym: "4,6-Dimethyl-N-phenyl-2-pyrimidinamine" RELATED [HMDB] synonym: "4,6-dimethyl-N-phenylpyrimidin-2-amine" EXACT IUPAC_NAME [IUPAC] synonym: "N-(4,6-dimethylpyrimidin-2-yl)aniline" RELATED [Alan_Wood's_Pesticides] xref: CAS:53112-28-0 {source="KEGG COMPOUND"} xref: CAS:53112-28-0 {source="ChemIDplus"} xref: CAS:53112-28-0 {source="NIST Chemistry WebBook"} xref: HMDB:HMDB0033135 xref: KEGG:C11180 xref: Pesticides:pyrimethanil {source="Alan Wood's Pesticides"} xref: PMID:22949075 {source="Europe PMC"} xref: PMID:23246620 {source="Europe PMC"} xref: PMID:23258318 {source="Europe PMC"} xref: PMID:23410121 {source="Europe PMC"} xref: PMID:23436777 {source="Europe PMC"} xref: PMID:23673061 {source="Europe PMC"} xref: PMID:23993516 {source="Europe PMC"} xref: PMID:24081744 {source="Europe PMC"} xref: PMID:24365971 {source="Europe PMC"} xref: PMID:24380616 {source="Europe PMC"} xref: PMID:24652239 {source="Europe PMC"} xref: PMID:24835131 {source="Europe PMC"} xref: PMID:25145229 {source="Europe PMC"} xref: PMID:25216469 {source="Europe PMC"} xref: PPDB:573 xref: Reaxys:151589 {source="Reaxys"} xref: Wikipedia:Pyrimethanil is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:50995 ! secondary amino compound is_a: CHEBI:87208 ! anilinopyrimidine fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:72768 ! has role aryl hydrocarbon receptor agonist relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H13N3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H13N3/c1-9-8-10(2)14-12(13-9)15-11-6-4-3-5-7-11/h3-8H,1-2H3,(H,13,14,15)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZLIBICFPKPWGIZ-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "199.25170" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "199.11095" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cc(C)nc(Nc2ccccc2)n1" xsd:string [Term] id: CHEBI:87012 name: amide antifungal agent namespace: chebi_ontology def: "A compound that has significant antifungal properties whose structure contains an amide moiety." [] subset: 3_STAR synonym: "amide antifungal agents" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87015 name: anilide fungicide namespace: chebi_ontology def: "Any amide fungicide whose structure contains an anilide group." [] subset: 3_STAR synonym: "anilide fungicides" RELATED [ChEBI] is_a: CHEBI:60600 ! amide fungicide [Term] id: CHEBI:87034 name: aromatic fungicide namespace: chebi_ontology def: "An organic aromatic compound that has been used as a fungicide." [] subset: 3_STAR synonym: "aromatic fungicides" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87036 name: benzimidazole fungicide namespace: chebi_ontology def: "Compounds that contain a benzimidazole moiety as a key feature of their structure and which have been used as fungicides." [] subset: 3_STAR synonym: "benzimidazole fungicides" RELATED [ChEBI] is_a: CHEBI:22715 ! benzimidazoles relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87037 name: benzimidazole precursor fungicide namespace: chebi_ontology def: "Compounds based on 1,2-phenylenediamine in which one or both of the primary amino groups have been derivatised so as to permit subsequent benzimidazole formation, and which have been used as fungicides." [] subset: 3_STAR synonym: "benzimidazole precursor fungicides" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: has_functional_parent CHEBI:34043 ! 1,2-phenylenediamine relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87061 name: carbamate fungicide namespace: chebi_ontology def: "Compounds that contain a carbamate ester moiety as a key feature of their structure and which have been used as fungicides." [] subset: 3_STAR synonym: "carbamate fungicides" RELATED [ChEBI] is_a: CHEBI:23003 ! carbamate ester relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87064 name: benzimidazolylcarbamate fungicide namespace: chebi_ontology def: "Any carbamate fungicide that contains a benzimidazolyl group attached to the nitrogen of the carbamate moiety." [] subset: 3_STAR synonym: "benzimidazolylcarbamate fungicides" RELATED [ChEBI] is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:87061 ! carbamate fungicide [Term] id: CHEBI:87066 name: carbanilate fungicide namespace: chebi_ontology def: "Any carbamate fungicide that has a phenyl or substituted-phenyl group attached to the nitrogen of the carbamate group." [] subset: 3_STAR synonym: "carbanilate fungicides" RELATED [ChEBI] is_a: CHEBI:87061 ! carbamate fungicide [Term] id: CHEBI:87067 name: conazole fungicide namespace: chebi_ontology def: "Any conazole antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "conazole fungicides" RELATED [ChEBI] is_a: CHEBI:86323 ! conazole antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87068 name: imidazole fungicide namespace: chebi_ontology def: "Any imidazole antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "imidazole fungicides" RELATED [ChEBI] is_a: CHEBI:86420 ! imidazole antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87069 name: imidazole antifungal drug namespace: chebi_ontology def: "Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals." [] subset: 3_STAR synonym: "imidazole antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86420 ! imidazole antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87071 name: conazole antifungal drug namespace: chebi_ontology def: "Any conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans." [] subset: 3_STAR synonym: "conazole antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86323 ! conazole antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87100 name: triazole fungicide namespace: chebi_ontology def: "Any triazole antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "triazole fungicides" RELATED [ChEBI] is_a: CHEBI:86426 ! triazole antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87101 name: triazole antifungal drug namespace: chebi_ontology def: "Any triazole antifungal agent that has been used for the treatment of fungal infections in humans or animals." [] subset: 3_STAR synonym: "triazole antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86426 ! triazole antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87113 name: antibiotic antifungal drug namespace: chebi_ontology def: "Any antibiotic antifungal agent used to treat fungal infections in humans or animals." [] subset: 3_STAR synonym: "antibiotic antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86478 ! antibiotic antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87114 name: antibiotic fungicide namespace: chebi_ontology def: "Any antibiotic antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "antibiotic fungicides" RELATED [ChEBI] is_a: CHEBI:86478 ! antibiotic antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87127 name: allylamine antifungal drug namespace: chebi_ontology def: "An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug." [] subset: 3_STAR synonym: "allylamine antifungal drugs" RELATED [ChEBI] xref: PMID:1732066 {source="Europe PMC"} is_a: CHEBI:35352 ! organonitrogen compound relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87132 name: morpholine antifungal agent namespace: chebi_ontology def: "A member of the class of morpholines that has significant antifungal properties." [] subset: 3_STAR synonym: "morpholine antifungal agents" RELATED [ChEBI] is_a: CHEBI:38785 ! morpholines relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87134 name: morpholine fungicide namespace: chebi_ontology def: "Any morpholine antifungal agent used as a fungicide." [] subset: 3_STAR synonym: "morpholine fungicides" RELATED [ChEBI] is_a: CHEBI:87132 ! morpholine antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87185 name: florfenicol namespace: chebi_ontology def: "A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture." [] subset: 3_STAR synonym: "(-)-Florfenicol" RELATED [ChemIDplus] synonym: "2,2-dichloro-N-{(1R,2S)-3-fluoro-1-hydroxy-1-[4-(methanesulfonyl)phenyl]propan-2-yl}acetamide" EXACT IUPAC_NAME [IUPAC] synonym: "D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide" RELATED [ChemIDplus] synonym: "florfenicol" RELATED INN [KEGG_DRUG] synonym: "Nuflor" RELATED BRAND_NAME [KEGG_DRUG] synonym: "Nuflor gold" RELATED BRAND_NAME [ChemIDplus] synonym: "Sch 25298" RELATED [ChemIDplus] synonym: "Sch-25298" RELATED [ChemIDplus] xref: CAS:73231-34-2 {source="KEGG DRUG"} xref: KEGG:D04194 xref: LINCS:LSM-5287 xref: Patent:EP14437 xref: Patent:US4235892 xref: PMID:25287575 {source="Europe PMC"} xref: PMID:25395188 {source="Europe PMC"} xref: PMID:25567063 {source="Europe PMC"} xref: PMID:25572306 {source="Europe PMC"} xref: PMID:25612770 {source="Europe PMC"} xref: PMID:25614968 {source="Europe PMC"} xref: PMID:25618189 {source="Europe PMC"} xref: PMID:25623169 {source="Europe PMC"} xref: PMID:25675893 {source="Europe PMC"} xref: PMID:25686865 {source="Europe PMC"} xref: PMID:25706107 {source="Europe PMC"} xref: PMID:25723132 {source="Europe PMC"} xref: PMID:25744433 {source="Europe PMC"} xref: PMID:25771961 {source="Europe PMC"} xref: PMID:25827198 {source="Europe PMC"} xref: PMID:25830490 {source="Europe PMC"} xref: PMID:25886128 {source="Europe PMC"} xref: PMID:25886555 {source="Europe PMC"} xref: PMID:25891823 {source="Europe PMC"} xref: PMID:25913426 {source="Europe PMC"} xref: PMID:25973625 {source="Europe PMC"} xref: PMID:26025252 {source="Europe PMC"} xref: PMID:26049592 {source="Europe PMC"} xref: Reaxys:4202553 {source="Reaxys"} xref: VSDB:1777 xref: Wikipedia:Florfenicol is_a: CHEBI:140325 ! secondary carboxamide is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:35850 ! sulfone is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:37143 ! organofluorine compound relationship: has_functional_parent CHEBI:36386 ! dichloroacetic acid relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H14Cl2FNO4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AYIRNRDRBQJXIF-NXEZZACHSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "358.21300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "357.00046" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl" xsd:string [Term] id: CHEBI:87195 name: dicarboximide fungicide namespace: chebi_ontology def: "Any dicarboximide antifungal agent used as a fungicide." [] subset: 3_STAR synonym: "dicarboximide fungicides" RELATED [ChEBI] is_a: CHEBI:87200 ! dicarboximide antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87197 name: dichlorophenyl dicarboximide fungicide namespace: chebi_ontology def: "A dicarboximide fungicide in which the nitrogen of the dicarboximide group is substituted by a dichlorophenyl group." [] subset: 3_STAR synonym: "dichlorophenyl dicarboximide fungicides" RELATED [ChEBI] is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:87195 ! dicarboximide fungicide [Term] id: CHEBI:87198 name: phthalimide fungicide namespace: chebi_ontology def: "A dicarboximide fungicide whose structure contains a phthalimide derivative." [] subset: 3_STAR synonym: "phthalimide fungicides" RELATED [ChEBI] is_a: CHEBI:87195 ! dicarboximide fungicide [Term] id: CHEBI:87200 name: dicarboximide antifungal agent namespace: chebi_ontology def: "A compound that has significant antifungal properties whose structure contains a dicarboximide moiety." [] subset: 3_STAR synonym: "dicarboximide antifungal agents" RELATED [ChEBI] is_a: CHEBI:35356 ! dicarboximide relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87204 name: pyrimidine antifungal agent namespace: chebi_ontology def: "A member of the class of pyrimidines that has significant antifungal properties." [] subset: 3_STAR synonym: "pyrimidine antifungal agents" RELATED [ChEBI] is_a: CHEBI:39447 ! pyrimidines relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87205 name: pyrimidine antifungal drug namespace: chebi_ontology def: "Any pyrimidine antifungal agent that has been used for the treatment of fungal infections in humans or animals." [] subset: 3_STAR synonym: "pyrimidine antifungal drugs" RELATED [ChEBI] is_a: CHEBI:87204 ! pyrimidine antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87207 name: pyrimidine fungicide namespace: chebi_ontology def: "Any pyrimidine antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "pyrimidine fungicides" RELATED [ChEBI] is_a: CHEBI:87204 ! pyrimidine antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87208 name: anilinopyrimidine fungicide namespace: chebi_ontology def: "Any pyrimidine fungicide in which the pyrimidine ring is substituted by the nitrogen of an aniline moiety." [] subset: 3_STAR synonym: "anilinopyrimidine fungicides" RELATED [ChEBI] is_a: CHEBI:87207 ! pyrimidine fungicide [Term] id: CHEBI:87209 name: virginiamycin namespace: chebi_ontology def: "A mixture of cyclic polypeptide streptogramin antibiotics produced by Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. The two major components are virginiamycin M1 (also known as pristinamycin IIA) and virginiamycin S1. Virginiamycin has been widely used as a growth promotion agent in livestock and has been to have bacteriostatic activity against Gram-positive organisms such as staphylococci and streptococci." [] subset: 3_STAR synonym: "virginiamicina" RELATED INN [WHO_MedNet] synonym: "virginiamycin" RELATED INN [WHO_MedNet] synonym: "virginiamycine" RELATED INN [WHO_MedNet] synonym: "virginiamycins" RELATED [ChEBI] synonym: "virginiamycinum" RELATED INN [WHO_MedNet] xref: CAS:11006-76-1 {source="ChemIDplus"} xref: CAS:11006-76-1 {source="KEGG DRUG"} xref: HMDB:HMDB0030520 xref: KEGG:D06311 xref: PMID:1493906 {source="Europe PMC"} xref: PMID:21676560 {source="Europe PMC"} xref: PMID:25874109 {source="Europe PMC"} xref: PMID:2907457 {source="Europe PMC"} xref: PMID:39060 {source="Europe PMC"} xref: PMID:4568014 {source="Europe PMC"} xref: PMID:8851577 {source="Europe PMC"} xref: Reaxys:13135027 {source="Reaxys"} xref: Wikipedia:Virginiamycin is_a: CHEBI:60004 ! mixture relationship: has_part CHEBI:46416 ! virginiamycin S1 relationship: has_part CHEBI:9997 ! pristinamycin IIA relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:87211 name: fluoroquinolone antibiotic namespace: chebi_ontology def: "An organonitrogen heterocyclic antibiotic containing a quinolone (or quinolone-like) moiety and which have a fluorine atom attached to the central ring system." [] subset: 3_STAR synonym: "fluoroquinolone antibiotics" RELATED [ChEBI] xref: PMID:24947193 {source="Europe PMC"} xref: PMID:25226071 {source="Europe PMC"} xref: PMID:8386356 {source="Europe PMC"} is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:37143 ! organofluorine compound [Term] id: CHEBI:87228 name: sulfonamide antibiotic namespace: chebi_ontology def: "A class of sulfonamides whose members generally have bacteriostatic antibiotic properties." [] subset: 3_STAR synonym: "sulfonamide antibiotics" RELATED [ChEBI] synonym: "sulfonamide antimicrobial agent" RELATED [ChEBI] synonym: "sulfonamide antimicrobial agents" RELATED [ChEBI] synonym: "sulphonamide antibiotic" RELATED [ChEBI] synonym: "sulphonamide antibiotics" RELATED [ChEBI] xref: PMID:24443047 {source="Europe PMC"} xref: PMID:24928456 {source="Europe PMC"} xref: PMID:25064257 {source="Europe PMC"} xref: PMID:25796473 {source="Europe PMC"} xref: PMID:26177406 {source="Europe PMC"} xref: Wikipedia:Sulfonamide_(medicine) is_a: CHEBI:35358 ! sulfonamide relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:87230 name: nitrofuran antibiotic namespace: chebi_ontology def: "A member of the class of furans in which the furan ring is substituted by a nitro group and which also has significant antibiotic properties." [] subset: 3_STAR synonym: "nitrofuran antibiotics" RELATED [ChEBI] synonym: "nitrofuran antimicrobial agent" RELATED [ChEBI] synonym: "nitrofuran antimicrobial agents" RELATED [ChEBI] xref: AGR:IND44688035 {source="Europe PMC"} xref: PMID:15776153 {source="Europe PMC"} xref: PMID:16999120 {source="Europe PMC"} xref: PMID:17691006 {source="Europe PMC"} xref: PMID:23785991 {source="Europe PMC"} xref: PMID:25437357 {source="Europe PMC"} xref: Wikipedia:Nitrofuran is_a: CHEBI:24129 ! furans is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic is_a: CHEBI:35716 ! C-nitro compound [Term] id: CHEBI:8733 name: Quinupristin-dalfopristin namespace: chebi_ontology subset: 2_STAR synonym: "Quinupristin-dalfopristin" EXACT [KEGG_COMPOUND] xref: CAS:126602-89-9 {source="KEGG COMPOUND"} xref: KEGG:C08034 xref: KEGG:D00854 is_a: CHEBI:50860 ! organic molecular entity property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H67N9O10S.C34H50N4O9S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H67N9O10S.C34H50N4O9S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46;1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65);9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b;10-9+,12-11+,23-18+/t31-,35?,37-,38+,39?,40+,43-,44+,45+;24-,25-,28-,31?,32-/m11/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PPKJUHVNTMYXOD-HVWWIRKTSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "1713.071" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1711.80301" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN(CC)CCS(=O)(=O)[C@@H]1CCN2C1C(=O)O[C@H](C(C)C)[C@H](C)\\C=C\\C(=O)NC\\C=C\\C(C)=C\\[C@@H](O)CC(=O)Cc1nc(co1)C2=O.CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)C2CC(=O)C(CS[C@@H]3CN4CCC3CC4)CN2C(=O)[C@H](Cc2ccc(cc2)N(C)C)N(C)C(=O)[C@@H]2CCCN2C1=O)c1ccccc1" xsd:string [Term] id: CHEBI:87835 name: framycetin(6+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the six amino groups of framycetin; major species at pH 7.3." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-bis(azaniumyl)-2-({3-O-[2,6-bis(azaniumyl)-2,6-dideoxy-beta-L-idopyranosyl]-beta-D-ribofuranosyl}oxy)-3-hydroxycyclohexyl 2,6-bis[(azaniumyl)]-2,6-dideoxy-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] synonym: "neomycin B" RELATED [UniProt] xref: MetaCyc:CPD-14142 {source="SUBMITTER"} xref: PMID:25230155 {source="SUBMITTER"} is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:7508 ! framycetin property_value: http://purl.obolibrary.org/obo/chebi/charge "+6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H52N6O13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/p+6/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PGBHMTALBVVCIT-VCIWKGPPSA-T" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "620.692" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "620.35594" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H]1([C@H]([C@@H]([C@@H]([NH3+])[C@@H](O[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)O[C@H]3[C@@H]([C@H](C[C@H]([C@@H]3O)[NH3+])[NH3+])O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C[NH3+])O)O)[NH3+])O1)O)O)C[NH3+]" xsd:string [Term] id: CHEBI:88061 name: polyamine namespace: chebi_ontology def: "Any organic amino compound that contains two or more amino groups." [] subset: 3_STAR synonym: "polyamines" RELATED [ChEBI] xref: Wikipedia:Polyamine is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:88184 name: metal allergen namespace: chebi_ontology def: "Any metal which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic metal" RELATED [ChEBI] synonym: "allergenic metals" RELATED [ChEBI] synonym: "metal allergens" RELATED [ChEBI] is_a: CHEBI:33521 ! metal atom relationship: RO:0000087 CHEBI:50904 ! has role allergen [Term] id: CHEBI:88187 name: penicillin allergen namespace: chebi_ontology def: "Any penicillin which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic penicillin" RELATED [ChEBI] synonym: "allergenic penicillin compound" RELATED [ChEBI] synonym: "allergenic penicillin compounds" RELATED [ChEBI] synonym: "allergenic penicillins" RELATED [ChEBI] synonym: "penicillin allergens" RELATED [ChEBI] is_a: CHEBI:17334 ! penicillin [Term] id: CHEBI:88188 name: drug allergen namespace: chebi_ontology def: "Any drug which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic drug" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:50904 ! allergen [Term] id: CHEBI:88225 name: beta-lactam antibiotic allergen namespace: chebi_ontology def: "Any beta-lactam antibiotic which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic beta-lactam antibiotic" RELATED [ChEBI] synonym: "allergenic beta-lactam antibiotics" RELATED [ChEBI] synonym: "beta-lactam antibiotic allergens" RELATED [ChEBI] is_a: CHEBI:27933 ! beta-lactam antibiotic relationship: RO:0000087 CHEBI:50904 ! has role allergen [Term] id: CHEBI:88227 name: potassium ionophore namespace: chebi_ontology def: "Any ionophore capable of transportation of potassium ions across membranes." [] subset: 3_STAR synonym: "potassium ionophores" RELATED [ChEBI] xref: PMID:11841304 {source="Europe PMC"} is_a: CHEBI:24869 ! ionophore [Term] id: CHEBI:8984 name: sodium dodecyl sulfate namespace: chebi_ontology def: "An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate." [] subset: 3_STAR synonym: "SDS" RELATED [KEGG_COMPOUND] synonym: "SLS" RELATED [ChemIDplus] synonym: "Sodium dodecyl sulfate" EXACT [KEGG_COMPOUND] synonym: "sodium dodecyl sulphate" RELATED [ChemIDplus] synonym: "sodium dodecylsulfate" RELATED [ChemIDplus] synonym: "Sodium lauryl sulfate" RELATED [KEGG_COMPOUND] synonym: "sodium lauryl sulphate" RELATED [ChemIDplus] xref: Beilstein:3599286 {source="Beilstein"} xref: CAS:151-21-3 {source="ChemIDplus"} xref: CAS:151-21-3 {source="KEGG COMPOUND"} xref: DrugBank:DB00815 xref: Gmelin:117722 {source="Gmelin"} xref: KEGG:C11166 xref: KEGG:D01045 xref: PMID:29079364 {source="Europe PMC"} is_a: CHEBI:38700 ! organic sodium salt relationship: has_part CHEBI:23872 ! dodecyl sulfate relationship: RO:0000087 CHEBI:27780 ! has role detergent relationship: RO:0000087 CHEBI:50533 ! has role protein denaturant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H25NaO4S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DBMJMQXJHONAFJ-UHFFFAOYSA-M" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "288.38027" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "288.13712" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na+].CCCCCCCCCCCCOS([O-])(=O)=O" xsd:string [Term] id: CHEBI:90710 name: receptor modulator namespace: chebi_ontology alt_id: CHEBI:189678 def: "A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors." [] subset: 3_STAR synonym: "receptor modulators" RELATED [ChEBI] xref: Wikipedia:Receptor_modulator is_a: CHEBI:23888 ! drug [Term] id: CHEBI:90799 name: dipeptide zwitterion namespace: chebi_ontology def: "Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3." [] subset: 3_STAR synonym: "a dipeptide" RELATED [UniProt] is_a: CHEBI:60466 ! peptide zwitterion relationship: is_tautomer_of CHEBI:46761 ! dipeptide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H6N2O3R2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "130.102" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "130.03784" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(C(NC(C([O-])=O)*)=O)*" xsd:string [Term] id: CHEBI:91007 name: aromatic carboxylate namespace: chebi_ontology def: "A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3." [] subset: 3_STAR synonym: "an aromatic carboxylate" RELATED [UniProt] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:33859 ! aromatic carboxylic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C([O-])=O" xsd:string [Term] id: CHEBI:9168 name: sirolimus namespace: chebi_ontology alt_id: CHEBI:45276 alt_id: CHEBI:67812 def: "A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent." [] subset: 3_STAR synonym: "(-)-Rapamycin" RELATED [ChemIDplus] synonym: "(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone" RELATED [IUPAC] synonym: "(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone" EXACT IUPAC_NAME [IUPAC] synonym: "Antibiotic AY 22989" RELATED [DrugBank] synonym: "Rapamune" RELATED BRAND_NAME [DrugBank] synonym: "rapamycin" RELATED [ChEBI] synonym: "Sirolimus" EXACT [KEGG_COMPOUND] synonym: "sirolimus" RELATED INN [WHO_MedNet] synonym: "sirolimusum" RELATED INN [WHO_MedNet] xref: CAS:53123-88-9 {source="ChemIDplus"} xref: CAS:53123-88-9 {source="KEGG COMPOUND"} xref: Drug_Central:2446 {source="DrugCentral"} xref: DrugBank:DB00877 xref: HMDB:HMDB0015015 xref: KEGG:C07909 xref: KEGG:D00753 xref: KNApSAcK:C00018055 xref: LIPID_MAPS_instance:LMPK06000003 {source="LIPID MAPS"} xref: PDBeChem:RAP xref: PMID:19587680 {source="Europe PMC"} xref: PMID:22960739 {source="Europe PMC"} xref: PMID:22981852 {source="Europe PMC"} xref: PMID:22984623 {source="Europe PMC"} xref: PMID:24341993 {source="Europe PMC"} xref: PMID:24409289 {source="Europe PMC"} xref: Reaxys:5848501 {source="Reaxys"} xref: Wikipedia:Rapamycin is_a: CHEBI:145565 ! macrolide lactam is_a: CHEBI:25698 ! ether is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:59770 ! cyclic acetal is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:68481 ! has role mTOR inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C51H79NO13" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QFJCIRLUMZQUOT-HPLJOQBZSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "914.17190" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "913.55514" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(CC[C@@H](O)[C@@H](C1)OC)C[C@@H](C)[C@]1([H])CC(=O)[C@H](C)\\C=C(C)\\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\\C=C\\C=C\\C=C(C)\\[C@H](C[C@]2([H])CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@@]2([H])C(=O)O1)OC" xsd:string [Term] id: CHEBI:9212 name: sparfloxacin namespace: chebi_ontology subset: 3_STAR synonym: "5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "Sparfloxacin" EXACT [KEGG_COMPOUND] xref: Beilstein:3658018 {source="ChemIDplus"} xref: CAS:110871-86-8 {source="KEGG COMPOUND"} xref: CAS:110871-86-8 {source="ChemIDplus"} xref: Drug_Central:2466 {source="DrugCentral"} xref: DrugBank:DB01208 xref: KEGG:C07662 xref: KEGG:D00590 xref: LINCS:LSM-5251 xref: Wikipedia:Sparfloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H22F2N4O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DZZWHBIBMUVIIW-DTORHVGOSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "392.39980" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "392.16600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H]1CN(C[C@@H](C)N1)c1c(F)c(N)c2c(c1F)n(cc(C(O)=O)c2=O)C1CC1" xsd:string [Term] id: CHEBI:9215 name: spectinomycin namespace: chebi_ontology alt_id: CHEBI:45551 def: "A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis." [] subset: 3_STAR synonym: "(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one" EXACT IUPAC_NAME [IUPAC] synonym: "Antibiotic 2233wp" RELATED [ChemIDplus] synonym: "espectinomicina" RELATED INN [DrugBank] synonym: "spectinomycin" RELATED INN [KEGG_DRUG] synonym: "spectinomycine" RELATED INN [DrugBank] synonym: "spectinomycinum" RELATED INN [DrugBank] xref: CAS:1695-77-8 {source="KEGG COMPOUND"} xref: CAS:1695-77-8 {source="ChemIDplus"} xref: Drug_Central:2468 {source="DrugCentral"} xref: DrugBank:DB00919 xref: HMDB:HMDB0015055 xref: KEGG:C02078 xref: KEGG:D08526 xref: LINCS:LSM-5298 xref: Patent:US4203903 xref: Patent:WO2005041984 xref: PDBeChem:SCM xref: PMID:23183436 {source="Europe PMC"} xref: PMID:23847609 {source="Europe PMC"} xref: PMID:24020122 {source="Europe PMC"} xref: PMID:24402501 {source="Europe PMC"} xref: PMID:24503209 {source="Europe PMC"} xref: PMID:30033166 {source="Europe PMC"} xref: PMID:32116136 {source="Europe PMC"} xref: Reaxys:2171701 {source="Reaxys"} xref: Wikipedia:Spectinomycin is_a: CHEBI:146295 ! pyranobenzodioxin is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:50995 ! secondary amino compound is_a: CHEBI:59770 ! cyclic acetal is_a: CHEBI:59780 ! cyclic hemiketal relationship: is_conjugate_base_of CHEBI:146260 ! spectinomycin(1+) relationship: is_conjugate_base_of CHEBI:77315 ! spectinomycin(2+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H24N2O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UNFWWIHTNXNPBV-WXKVUWSESA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "332.34960" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "332.15835" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O" xsd:string [Term] id: CHEBI:9242 name: spiroxamine namespace: chebi_ontology alt_id: CHEBI:546779 def: "The spiroketal resulting from the formal condensation of 4-tert-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powdery mildew in the production of cereals, bananas and grapes." [] subset: 3_STAR synonym: "(8-tert-Butyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-ethyl-propyl-amine" RELATED [ChEMBL] synonym: "8-(1,1-dimethylethyl)-N-ethyl-N-propyl-1,4-dioxaspiro(4.5)decane-2-methanamine" RELATED [ChEBI] synonym: "Impulse" RELATED BRAND_NAME [ChEBI] synonym: "KWG4168" RELATED [KEGG_COMPOUND] synonym: "N-[(8-tert-butyl-1,4-dioxaspiro[4.5]dec-2-yl)methyl]-N-ethylpropan-1-amine" EXACT IUPAC_NAME [IUPAC] synonym: "Prosper" RELATED BRAND_NAME [ChEBI] synonym: "Spiroxamine" EXACT [KEGG_COMPOUND] xref: AGR:IND43667533 {source="Europe PMC"} xref: CAS:118134-30-8 {source="KEGG COMPOUND"} xref: CAS:118134-30-8 {source="ChemIDplus"} xref: KEGG:C11124 xref: Patent:DE3735555 xref: Patent:US4851405 xref: Pesticides:spiroxamine {source="Alan Wood's Pesticides"} xref: PMID:16366700 {source="Europe PMC"} xref: PMID:16526469 {source="Europe PMC"} xref: PMID:17804411 {source="ChEMBL"} xref: PMID:19733892 {source="Europe PMC"} xref: PMID:20060629 {source="Europe PMC"} xref: PPDB:599 xref: Reaxys:11342560 {source="Reaxys"} is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:72600 ! spiroketal relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H35NO2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H35NO2/c1-6-12-19(7-2)13-16-14-20-18(21-16)10-8-15(9-11-18)17(3,4)5/h15-16H,6-14H2,1-5H3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PUYXTUJWRLOUCW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "297.47600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "297.26678" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCN(CC)CC1COC2(CCC(CC2)C(C)(C)C)O1" xsd:string [Term] id: CHEBI:9321 name: sulbactam namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide" RELATED [ChemIDplus] synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide" RELATED [IUPAC] synonym: "2,2-dimethyl-1,1-dioxidopenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "penicillanic acid 1,1-dioxide" RELATED [ChEBI] synonym: "penicillanic acid sulfone" RELATED [ChEBI] synonym: "sulbactam" RELATED INN [ChemIDplus] synonym: "sulbactamum" RELATED INN [ChemIDplus] xref: Beilstein:4192832 {source="Beilstein"} xref: CAS:68373-14-8 {source="KEGG COMPOUND"} xref: CAS:68373-14-8 {source="ChemIDplus"} xref: Drug_Central:2492 {source="DrugCentral"} xref: KEGG:C07770 xref: KEGG:C14001 xref: KEGG:D02223 xref: KEGG:D08533 xref: LINCS:LSM-5553 xref: Patent:BE867859 xref: Patent:US4234579 xref: Wikipedia:Sulbactam is_a: CHEBI:25865 ! penicillanic acids property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H11NO5S" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FKENQMMABCRJMK-RITPCOANSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "233.24200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "233.03579" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CC(=O)N1[C@@H](C(O)=O)C(C)(C)S2(=O)=O" xsd:string [Term] id: CHEBI:9448 name: terbinafine namespace: chebi_ontology def: "A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections." [] subset: 3_STAR synonym: "(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine" EXACT IUPAC_NAME [IUPAC] synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine" RELATED [ChemIDplus] synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine" RELATED [ChemIDplus] synonym: "terbinafina" RELATED INN [WHO_MedNet] synonym: "terbinafine" EXACT [WHO_MedNet] synonym: "terbinafine" RELATED INN [KEGG_DRUG] synonym: "terbinafinum" RELATED INN [WHO_MedNet] xref: CAS:91161-71-6 {source="ChemIDplus"} xref: CAS:91161-71-6 {source="KEGG COMPOUND"} xref: Drug_Central:2597 {source="DrugCentral"} xref: DrugBank:DB00857 xref: HMDB:HMDB0014995 xref: KEGG:C08079 xref: KEGG:D02375 xref: MetaCyc:CPD-10571 xref: PMID:23750489 {source="Europe PMC"} xref: PMID:23802806 {source="Europe PMC"} xref: PMID:23841559 {source="Europe PMC"} xref: PMID:23895037 {source="Europe PMC"} xref: PMID:24126579 {source="Europe PMC"} xref: PMID:24352873 {source="Europe PMC"} xref: PMID:24389279 {source="Europe PMC"} xref: PMID:24410098 {source="Europe PMC"} xref: PMID:24447130 {source="Europe PMC"} xref: PMID:24452843 {source="Europe PMC"} xref: PMID:24477462 {source="Europe PMC"} xref: PMID:24490976 {source="Europe PMC"} xref: PMID:24497012 {source="Europe PMC"} xref: PMID:24533442 {source="Europe PMC"} xref: PMID:24563892 {source="Europe PMC"} xref: PMID:24576265 {source="Europe PMC"} xref: PMID:24581620 {source="Europe PMC"} xref: PMID:24588014 {source="Europe PMC"} xref: Reaxys:4256376 {source="Reaxys"} xref: Wikipedia:Terbinafine is_a: CHEBI:25477 ! naphthalenes is_a: CHEBI:32876 ! tertiary amine is_a: CHEBI:59831 ! enyne is_a: CHEBI:87127 ! allylamine antifungal drug relationship: is_conjugate_base_of CHEBI:77615 ! terbinafine(1+) relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor relationship: RO:0000087 CHEBI:59285 ! has role EC 1.14.13.132 (squalene monooxygenase) inhibitor relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H25N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DOMXUEMWDBAQBQ-WEVVVXLNSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "291.42990" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "291.19870" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C\\C=C\\C#CC(C)(C)C)Cc1cccc2ccccc12" xsd:string [Term] id: CHEBI:94759 name: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole namespace: chebi_ontology subset: 2_STAR synonym: "fasinex" RELATED [DrugCentral] xref: CAS:68786-66-3 {source="DrugCentral"} xref: Drug_Central:2734 {source="DrugCentral"} xref: LINCS:LSM-5875 xref: VSDB:1773 is_a: CHEBI:35618 ! aromatic ether property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H9Cl3N2OS" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NQPDXQQQCQDHHW-UHFFFAOYSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "359.659" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "357.95012" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CSC1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl" xsd:string [Term] id: CHEBI:9587 name: ticarcillin namespace: chebi_ontology def: "A penicillin compound having a 6beta-[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6beta-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-2,2-dimethylpenam-3alpha-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "alpha-carboxy-3-thienylmethylpenicillin" RELATED [Patent] synonym: "ticarcilina" RELATED INN [ChemIDplus] synonym: "ticarcillin" RELATED INN [ChemIDplus] synonym: "ticarcilline" RELATED INN [ChemIDplus] synonym: "ticarcillinum" RELATED INN [ChemIDplus] xref: Beilstein:6009447 {source="Beilstein"} xref: CAS:34787-01-4 {source="ChemIDplus"} xref: CAS:34787-01-4 {source="KEGG COMPOUND"} xref: Drug_Central:2656 {source="DrugCentral"} xref: DrugBank:DB01607 xref: KEGG:C07139 xref: KEGG:D08593 xref: Patent:BE646991 xref: Patent:US3282926 xref: PMID:12569987 {source="Europe PMC"} xref: PMID:1384868 {source="Europe PMC"} xref: PMID:23775821 {source="Europe PMC"} xref: PMID:24369293 {source="Europe PMC"} xref: PMID:29017833 {source="Europe PMC"} xref: Reaxys:6009447 {source="Reaxys"} xref: Wikipedia:Ticarcillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51811 ! ticarcillin(2-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H16N2O6S2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OHKOGUYZJXTSFX-KZFFXBSXSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "384.42700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "384.04498" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@]([H])(C(O)=O)c1ccsc1)C(O)=O" xsd:string [Term] id: CHEBI:9665 name: triadimefon namespace: chebi_ontology def: "A racemate comprising equal amounts of (R)- and (S)-triadimefon. A fungicide used to control powdery mildew, rusts and other infections in crops." [] subset: 3_STAR synonym: "(+-)-triadimefon" RELATED [ChEBI] synonym: "(RS)-triadimefon" RELATED [ChEBI] synonym: "1-(1,2,4-Triazoyl-1)-1-(4-chloro-phenoxy)-3,3-dimethylbutanone" RELATED [ChemIDplus] synonym: "1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one" RELATED [ChemIDplus] synonym: "1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butanone" RELATED [NIST_Chemistry_WebBook] synonym: "1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone" RELATED [Alan_Wood's_Pesticides] synonym: "rac-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one" EXACT IUPAC_NAME [IUPAC] synonym: "rac-triadimefon" RELATED [ChEBI] synonym: "racemic triadimefon" RELATED [ChEBI] synonym: "triadimefone" RELATED [MetaCyc] xref: CAS:43121-43-3 {source="ChemIDplus"} xref: CAS:43121-43-3 {source="NIST Chemistry WebBook"} xref: CAS:43121-43-3 {source="KEGG COMPOUND"} xref: KEGG:C11156 xref: MetaCyc:CPD-4061 xref: Pesticides:triadimefon {source="Alan Wood's Pesticides"} xref: PMID:23419873 {source="Europe PMC"} xref: PMID:23876258 {source="Europe PMC"} xref: PMID:24342051 {source="Europe PMC"} xref: PMID:24531054 {source="Europe PMC"} xref: PMID:24846121 {source="Europe PMC"} xref: PMID:24962053 {source="Europe PMC"} xref: PMID:25011125 {source="Europe PMC"} xref: Reaxys:619231 {source="Reaxys"} xref: Wikipedia:Triadimefon is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: has_part CHEBI:84003 ! (R)-triadimefon relationship: has_part CHEBI:84004 ! (S)-triadimefon relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H16ClN3O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "293.74900" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "293.09310" xsd:string [Term] id: CHEBI:9700 name: tridemorph namespace: chebi_ontology def: "A mixture of 4-alkyl-2,6-dimethylmorpholines, where 'alkyl' is a mixture of C11 to C14 homologues of which 60-70% is tridecyl. A systemic fungicide, it is no longer approved for use within the European Union." [] subset: 3_STAR synonym: "BAS 2203F" RELATED [ChemIDplus] synonym: "Calixin" RELATED BRAND_NAME [ChemIDplus] synonym: "Tridemorph" EXACT [KEGG_COMPOUND] synonym: "tridemorphe" RELATED [ChEBI] xref: AGR:IND84012971 {source="Europe PMC"} xref: AGR:IND93043841 {source="Europe PMC"} xref: CAS:81412-43-3 {source="ChemIDplus"} xref: CAS:81412-43-3 {source="Alan Wood's Pesticides"} xref: HMDB:HMDB0031810 xref: KEGG:C11285 xref: Patent:BE614214 xref: Patent:US3468885 xref: Pesticides:tridemorph {source="Alan Wood's Pesticides"} xref: PMID:15092713 {source="Europe PMC"} xref: PMID:1841872 {source="Europe PMC"} xref: PMID:6740510 {source="Europe PMC"} xref: Reaxys:8389338 {source="Reaxys"} xref: Wikipedia:Tridemorph is_a: CHEBI:60004 ! mixture is_a: CHEBI:87134 ! morpholine fungicide relationship: has_part CHEBI:83297 ! 4-dodecyl-2,6-dimethylmorpholine relationship: has_part CHEBI:83365 ! 2,6-dimethyl-4-tridecylmorpholine relationship: has_part CHEBI:83368 ! 2,6-dimethyl-4-undecylmorpholine relationship: has_part CHEBI:83370 ! 2,6-dimethyl-4-tetradecylmorpholine relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:9763 name: trovafloxacin namespace: chebi_ontology def: "A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure." [] subset: 3_STAR synonym: "7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid" EXACT IUPAC_NAME [IUPAC] synonym: "trovafloxacin" RELATED INN [KEGG_DRUG] synonym: "trovafloxacine" RELATED INN [WHO_MedNet] synonym: "trovafloxacino" RELATED INN [WHO_MedNet] synonym: "trovafloxacinum" RELATED INN [WHO_MedNet] xref: CAS:147059-72-1 {source="ChemIDplus"} xref: CAS:147059-72-1 {source="KEGG COMPOUND"} xref: Drug_Central:2777 {source="DrugCentral"} xref: DrugBank:DB00685 xref: HMDB:HMDB0014823 xref: KEGG:C07664 xref: KEGG:D08654 xref: PMID:20022474 {source="Europe PMC"} xref: PMID:20462743 {source="Europe PMC"} xref: PMID:20538741 {source="Europe PMC"} xref: PMID:20655887 {source="Europe PMC"} xref: PMID:21151465 {source="Europe PMC"} xref: PMID:22305082 {source="Europe PMC"} xref: PMID:23727874 {source="Europe PMC"} xref: PMID:24097668 {source="Europe PMC"} xref: PMID:24525298 {source="Europe PMC"} xref: Reaxys:8172628 {source="Reaxys"} xref: Wikipedia:Trovafloxacin is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:33709 ! amino acid is_a: CHEBI:38295 ! azabicycloalkane is_a: CHEBI:38582 ! difluorobenzene is_a: CHEBI:50994 ! primary amino compound is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:73537 ! 1,8-naphthyridine derivative is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_conjugate_base_of CHEBI:77569 ! trovafloxacin(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H15F3N4O3" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16+" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WVPSKSLAZQPAKQ-CDMJZVDBSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "416.35330" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "416.10962" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H]1[C@@H]2CN(C[C@H]12)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)-c1ccc(F)cc1F" xsd:string [Term] id: CHEBI:9948 name: verapamil namespace: chebi_ontology def: "A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine." [] subset: 3_STAR synonym: "rac-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" EXACT IUPAC_NAME [IUPAC] synonym: "Verapamil" EXACT [KEGG_COMPOUND] synonym: "verapamil" RELATED INN [WHO_MedNet] synonym: "verapamil" RELATED INN [ChemIDplus] synonym: "verapamilo" RELATED INN [ChemIDplus] synonym: "verapamilum" RELATED INN [ChemIDplus] xref: Beilstein:2825000 {source="Beilstein"} xref: CAS:52-53-9 {source="ChemIDplus"} xref: CAS:52-53-9 {source="NIST Chemistry WebBook"} xref: CAS:52-53-9 {source="KEGG COMPOUND"} xref: DrugBank:DB00661 xref: HMDB:HMDB0001850 xref: KEGG:C07188 xref: KEGG:D02356 xref: PMID:11142488 {source="Europe PMC"} xref: PMID:11389609 {source="Europe PMC"} xref: PMID:11454724 {source="Europe PMC"} xref: PMID:11975770 {source="Europe PMC"} xref: PMID:12454681 {source="Europe PMC"} xref: PMID:14681337 {source="Europe PMC"} xref: PMID:16545584 {source="Europe PMC"} xref: PMID:17525564 {source="Europe PMC"} xref: PMID:17724247 {source="Europe PMC"} xref: PMID:18093581 {source="Europe PMC"} xref: PMID:18337499 {source="Europe PMC"} xref: PMID:19125880 {source="Europe PMC"} xref: PMID:24532601 {source="Europe PMC"} xref: PMID:24577794 {source="Europe PMC"} xref: PMID:25297337 {source="Europe PMC"} xref: PMID:25331694 {source="Europe PMC"} xref: PMID:25650380 {source="Europe PMC"} xref: PMID:25968157 {source="Europe PMC"} xref: PMID:26046259 {source="Europe PMC"} xref: PMID:26504804 {source="Europe PMC"} xref: PMID:26553277 {source="Europe PMC"} xref: PMID:26567612 {source="Europe PMC"} xref: PMID:8861548 {source="Europe PMC"} xref: Reaxys:2825000 {source="Reaxys"} xref: Wikipedia:Verapamil is_a: CHEBI:60911 ! racemate relationship: has_part CHEBI:77734 ! dexverapamil relationship: has_part CHEBI:77736 ! (S)-verapamil relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent relationship: RO:0000087 CHEBI:35674 ! has role antihypertensive agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:38070 ! has role anti-arrhythmia drug relationship: RO:0000087 CHEBI:38215 ! has role calcium channel blocker relationship: RO:0000087 CHEBI:62872 ! has role EC 1.2.3.1 (aldehyde oxidase) inhibitor relationship: RO:0000087 CHEBI:77255 ! has role EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor relationship: RO:0000087 CHEBI:77745 ! has role EC 3.4.24.18 (meprin A) inhibitor relationship: RO:0000087 CHEBI:77747 ! has role EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H38N2O4" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "454.60160" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "454.28316" xsd:string [Term] id: CHEBI:9986 name: vinclozolin namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp." [] subset: 3_STAR synonym: "(+-)-vinclozolin" RELATED [ChEBI] synonym: "(RS)-vinclozolin" RELATED [ChEBI] synonym: "3-(3,5-Dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione" RELATED [ChemIDplus] synonym: "3-(3,5-Dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione" RELATED [ChemIDplus] synonym: "N-3,5-Dichlorophenyl-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione" RELATED [NIST_Chemistry_WebBook] synonym: "rac-3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione" EXACT IUPAC_NAME [IUPAC] synonym: "rac-vinclozolin" RELATED [ChEBI] synonym: "racemic vinclozolin" RELATED [ChEBI] synonym: "Vinchlozoline" RELATED [ChemIDplus] synonym: "Vinclozoline" RELATED [ChemIDplus] xref: CAS:50471-44-8 {source="ChemIDplus"} xref: CAS:50471-44-8 {source="NIST Chemistry WebBook"} xref: CAS:50471-44-8 {source="KEGG COMPOUND"} xref: KEGG:C10981 xref: Pesticides:vinclozolin {source="Alan Wood's Pesticides"} xref: PMID:24072643 {source="Europe PMC"} xref: PMID:24333988 {source="Europe PMC"} xref: PMID:24388192 {source="Europe PMC"} xref: PMID:24497202 {source="Europe PMC"} xref: PMID:24636578 {source="Europe PMC"} xref: PMID:24995616 {source="Europe PMC"} xref: PMID:25019461 {source="Europe PMC"} xref: PMID:25051444 {source="Europe PMC"} xref: PMID:25111804 {source="Europe PMC"} xref: PMID:25161548 {source="Europe PMC"} xref: PMID:25190560 {source="Europe PMC"} xref: PMID:25324206 {source="Europe PMC"} xref: Reaxys:1080192 {source="Reaxys"} xref: Reaxys:8331312 {source="Reaxys"} xref: Wikipedia:Vinclozolin is_a: CHEBI:60911 ! racemate is_a: CHEBI:87197 ! dichlorophenyl dicarboximide fungicide relationship: has_part CHEBI:83733 ! (R)-vinclozolin relationship: has_part CHEBI:83735 ! (S)-vinclozolin relationship: RO:0000087 CHEBI:35497 ! has role androgen antagonist relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:9997 name: pristinamycin IIA namespace: chebi_ontology alt_id: CHEBI:46395 def: "A macrolide that is (together with pristinamycin IA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organisms including methicillin-resistant Staphylococcus aureus." [] subset: 3_STAR synonym: "(3R,4R,5E,10E,12E,14S)-14-hydroxy-3-isopropyl-4,12-dimethyl-8,9,14,15,24,25-hexahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone" EXACT IUPAC_NAME [IUPAC] synonym: "Mikamycin A" RELATED [KEGG_COMPOUND] synonym: "Ostreogrycin a" RELATED [ChemIDplus] synonym: "Streptogramin A" RELATED [KEGG_COMPOUND] synonym: "Virginiamycin factor M1" RELATED [ChemIDplus] synonym: "Virginiamycin M1" RELATED [KEGG_COMPOUND] xref: CAS:21411-53-0 {source="ChemIDplus"} xref: CAS:21411-53-0 {source="KEGG COMPOUND"} xref: DrugBank:DB01669 xref: KEGG:C11299 xref: PDBeChem:VIR xref: PMID:15480455 {source="Europe PMC"} xref: PMID:24324222 {source="Europe PMC"} xref: PMID:24687494 {source="Europe PMC"} xref: PMID:25223995 {source="Europe PMC"} xref: PMID:3096930 {source="Europe PMC"} xref: PMID:5905315 {source="Europe PMC"} xref: Reaxys:71867 {source="Reaxys"} xref: Wikipedia:Pristinamycin_IIA is_a: CHEBI:140325 ! secondary carboxamide is_a: CHEBI:140326 ! tertiary carboxamide is_a: CHEBI:23763 ! pyrroline is_a: CHEBI:24995 ! lactam is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:46812 ! 1,3-oxazoles is_a: CHEBI:51751 ! enamide relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C28H35N3O7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DAIKHDNSXMZDCU-FQTGFAPKSA-N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "525.59340" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "525.24750" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c2coc(CC(=O)C[C@H](O)\\C=C(/C)\\C=C\\CNC(=O)\\C=C\\[C@H]1C)n2" xsd:string [Term] id: CL:0000000 name: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FBbt:00007002 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: MESH:D002477 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000061 ! anatomical structure disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle relationship: has_part GO:0005634 {gci_filler="PATO:0001407", gci_relation="bearer_of"} ! nucleus relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="bearer_of"} ! nucleus relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: CL:0001061 name: abnormal cell def: "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." [GOC:add, GOC:cg, GOC:wdd] comment: https://github.com/obophenotype/cell-ontology/issues/448 xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: bearer_of PATO:0000460 ! abnormal relationship: bearer_of PATO:0000460 ! abnormal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/terms/date "2017-01-30T18:53:32Z" xsd:dateTime [Term] id: CL:0017505 name: increased nucleus size def: "A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell." [GOC:tfm] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: bearer_of PATO:0000586 ! increased size relationship: bearer_of PATO:0000586 ! increased size property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2009-12-23T10:53:24Z [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_pir subset: goslim_plant synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000045 name: autophagosome assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0070925 ! organelle assembly is_a: GO:1905037 ! autophagosome organization relationship: has_part GO:0019778 ! Atg12 activating enzyme activity relationship: has_part GO:0019786 ! protein-phosphatidylethanolamide deconjugating activity relationship: has_part GO:0061651 ! Atg12 conjugating enzyme activity relationship: has_part GO:0061660 ! Atg12 ligase activity [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005634 ! nucleus relationship: results_in_fission_of GO:0005634 ! nucleus [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: results_in_fusion_of GO:0031965 ! nuclear membrane relationship: results_in_fusion_of GO:0031965 ! nuclear membrane [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0006997 ! nucleus organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0048284 ! organelle fusion intersection_of: results_in_fusion_of GO:0005634 ! nucleus relationship: part_of GO:0006997 ! nucleus organization relationship: results_in_fusion_of GO:0005634 ! nucleus [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! protein-RNA complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0044207 ! translation initiation ternary complex relationship: part_of GO:0006413 ! translational initiation relationship: results_in_assembly_of GO:0044207 ! translation initiation ternary complex [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18737" xsd:anyURI [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: part_of GO:0006952 ! defense response relationship: part_of GO:0006952 ! defense response [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion intersection_of: has_primary_input CHEBI:16670 ! peptide [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002790 ! peptide secretion relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002790 ! peptide secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002790 ! peptide secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: part_of GO:0000003 ! reproduction [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] is_a: BFO:0000015 ! process disjoint_from: GO:0005575 ! cellular_component disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function alt_id: GO:0000496 def: "Binding to a nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "base pairing" NARROW [] is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0003677 name: DNA binding namespace: molecular_function alt_id: GO:0043566 def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003723 name: RNA binding namespace: molecular_function alt_id: GO:0000498 alt_id: GO:0044822 def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast synonym: "base pairing with RNA" NARROW [] synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] synonym: "poly-A RNA binding" RELATED [] xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0004176 name: ATP-dependent peptidase activity namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis." [GOC:mah] synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] xref: Reactome:R-HSA-9698929 "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex" is_a: GO:0008233 ! peptidase activity is_a: GO:0140657 ! ATP-dependent activity intersection_of: GO:0008233 ! peptidase activity intersection_of: has_part GO:0016887 ! ATP hydrolysis activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI [Term] id: GO:0004553 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function alt_id: GO:0016800 def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1.- xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG" xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP" xref: Reactome:R-HSA-9661820 "Bacterial GUSB hydrolyses BDG to BIL" is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0004568 name: chitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.14] synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" RELATED [EC:3.2.1.14] synonym: "chitodextrinase activity" RELATED [EC:3.2.1.14] synonym: "poly-beta-glucosaminidase activity" RELATED [EC:3.2.1.14] synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" RELATED [EC:3.2.1.14] xref: EC:3.2.1.14 xref: MetaCyc:3.2.1.14-RXN xref: Reactome:R-HSA-6786421 "CHIA hydrolyses chitin" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: prokaryote_subset synonym: "carrier" RELATED [] xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion" xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: has_primary_input CHEBI:18059 ! lipid relationship: has_primary_input CHEBI:18059 ! lipid relationship: part_of GO:0006869 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! lipid transport [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Binding to a protein." [GOC:go_curators] subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao1337158144] def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 is_a: BFO:0000040 ! material entity disjoint_from: GO:0008150 ! biological_process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17729" xsd:anyURI [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: prokaryote_subset synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0005622 name: intracellular anatomical structure namespace: cellular_component def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "intracellular" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0110165 ! cellular anatomical entity relationship: part_of CL:0000000 ! cell property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17776" xsd:anyURI [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle disjoint_from: GO:0005737 ! cytoplasm relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope relationship: part_of GO:0005634 ! nucleus relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast subset: prokaryote_subset xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular anatomical structure property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23023" xsd:anyURI [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005776 name: autophagosome namespace: cellular_component def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959] synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959] xref: NIF_Subcellular:sao8663416959 is_a: GO:0005773 ! vacuole [Term] id: GO:0005811 name: lipid droplet namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid particle" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005887 alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast subset: prokaryote_subset synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "integral component of plasma membrane" NARROW [] synonym: "integral to plasma membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "ectoplasm" NARROW [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0071944 ! cell periphery relationship: part_of GO:0071944 ! cell periphery property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26298" xsd:anyURI [Term] id: GO:0006033 name: chitin localization namespace: biological_process def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chitin localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chitin localization" EXACT [] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir synonym: "alcohol metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir synonym: "organic acid metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:64709 ! organic acid relationship: has_primary_input_or_output CHEBI:64709 ! organic acid [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_primary_input_or_output CHEBI:61120 ! nucleobase-containing molecular entity [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_yeast synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid relationship: has_primary_input CHEBI:33697 ! ribonucleic acid [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: prokaryote_subset synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Wikipedia:Translation_(genetics) is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process is_a: GO:0043043 ! peptide biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:16541 ! protein polypeptide chain intersection_of: part_of GO:0010467 ! gene expression relationship: ends_with GO:0006415 ! translational termination relationship: has_part GO:0006414 ! translational elongation relationship: has_primary_output CHEBI:16541 ! protein polypeptide chain relationship: part_of GO:0010467 ! gene expression relationship: starts_with GO:0006413 ! translational initiation [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: goslim_yeast synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0006412 ! translation relationship: starts_with GO:0001677 ! formation of translation initiation ternary complex [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: goslim_yeast synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006415 name: translational termination namespace: biological_process alt_id: GO:0006443 alt_id: GO:0006456 def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly relationship: part_of GO:0006412 ! translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] subset: goslim_yeast synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of amide metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006412 ! translation relationship: regulates GO:0006412 ! translation [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006413 ! translational initiation relationship: regulates GO:0006413 ! translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006414 ! translational elongation relationship: regulates GO:0006414 ! translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006415 ! translational termination relationship: regulates GO:0006415 ! translational termination [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: gocheck_do_not_annotate subset: goslim_yeast synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0016310 ! phosphorylation is_a: GO:0036211 ! protein modification process [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] subset: goslim_pir synonym: "peptide metabolism" EXACT [] is_a: GO:0043603 ! amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:16670 ! peptide relationship: has_primary_input_or_output CHEBI:16670 ! peptide [Term] id: GO:0006520 name: amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast subset: prokaryote_subset synonym: "amino acid and derivative metabolism" RELATED [] synonym: "cellular amino acid and derivative metabolic process" RELATED [] synonym: "cellular amino acid metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:37022 ! amino-acid anion relationship: has_primary_input_or_output CHEBI:37022 ! amino-acid anion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI [Term] id: GO:0006521 name: regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] synonym: "regulation of amino acid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006520 ! amino acid metabolic process relationship: regulates GO:0006520 ! amino acid metabolic process [Term] id: GO:0006553 name: lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine metabolism" EXACT [] xref: Wikipedia:Lysine is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast subset: prokaryote_subset synonym: "lipid metabolism" EXACT [] xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:18059 ! lipid relationship: has_primary_input_or_output CHEBI:18059 ! lipid [Term] id: GO:0006714 name: sesquiterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] synonym: "sesquiterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process alt_id: GO:0016096 def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732] synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:33655 ! aromatic compound relationship: has_primary_input_or_output CHEBI:33655 ! aromatic compound [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:26082 ! phosphorus molecular entity relationship: has_primary_input_or_output CHEBI:26082 ! phosphorus molecular entity [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:26020 ! phosphate relationship: has_primary_input_or_output CHEBI:26020 ! phosphate [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_metagenomics subset: goslim_pir synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:51143 ! nitrogen molecular entity relationship: has_primary_input_or_output CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: prokaryote_subset synonym: "single-organism transport" RELATED [] is_a: GO:0051234 ! establishment of localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20292" xsd:anyURI created_by: jl creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006817 name: phosphate ion transport namespace: biological_process def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "phosphate transport" RELATED [] is_a: GO:0015698 ! inorganic anion transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:35780 ! phosphate ion relationship: has_primary_input CHEBI:35780 ! phosphate ion [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005576 ! extracellular region relationship: occurs_in GO:0005576 ! extracellular region [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport intersection_of: GO:0006865 ! amino acid transport intersection_of: occurs_in GO:0005576 ! extracellular region [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast is_a: GO:0015849 ! organic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:33709 ! amino acid relationship: has_primary_input CHEBI:33709 ! amino acid [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:18059 ! lipid relationship: has_primary_input CHEBI:18059 ! lipid relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: goslim_generic subset: goslim_prokaryote subset: prokaryote_subset synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input PR:000000001 ! protein intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure relationship: part_of GO:0008104 ! protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process alt_id: GO:0016194 alt_id: GO:0016195 def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] subset: goslim_yeast synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0006810 ! transport intersection_of: process_has_causal_agent GO:0070382 ! exocytic vesicle relationship: has_part GO:0099500 ! vesicle fusion to plasma membrane relationship: process_has_causal_agent GO:0070382 ! exocytic vesicle [Term] id: GO:0006897 name: endocytosis namespace: biological_process alt_id: GO:0016193 alt_id: GO:0016196 alt_id: GO:0098701 def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] subset: goslim_yeast synonym: "endocytic import into cell" EXACT [] synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" NARROW [] synonym: "vesicle endocytosis" EXACT [] xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0098657 ! import into cell relationship: has_part GO:0006900 ! vesicle budding from membrane relationship: has_part GO:0010324 ! membrane invagination relationship: has_target_end_location GO:0031410 ! cytoplasmic vesicle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24907" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25268" xsd:anyURI [Term] id: GO:0006900 name: vesicle budding from membrane namespace: biological_process alt_id: GO:0006902 alt_id: GO:1902591 def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "single organism membrane budding" RELATED [GOC:TermGenie] synonym: "single-organism membrane budding" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: part_of GO:0016192 ! vesicle-mediated transport created_by: jl creation_date: 2013-12-19T15:26:17Z [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fusion_of GO:0012506 ! vesicle membrane relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: results_in_fusion_of GO:0012506 ! vesicle membrane [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Wikipedia:Autophagy_(cellular) is_a: GO:0044248 ! cellular catabolic process is_a: GO:0061919 ! process utilizing autophagic mechanism property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25541#issuecomment-1740659745" xsd:anyURI [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response namespace: biological_process alt_id: GO:0002217 alt_id: GO:0042829 def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006996 name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0043226 ! organelle relationship: results_in_organization_of GO:0043226 ! organelle created_by: jl creation_date: 2013-12-19T15:25:51Z [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [] synonym: "nuclear organization" EXACT [] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005634 ! nucleus relationship: results_in_organization_of GO:0005634 ! nucleus [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005635 ! nuclear envelope relationship: part_of GO:0006997 ! nucleus organization relationship: part_of GO:0010256 ! endomembrane system organization relationship: results_in_organization_of GO:0005635 ! nuclear envelope [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl synonym: "plasma membrane organisation" EXACT [] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005886 ! plasma membrane relationship: part_of GO:0010256 ! endomembrane system organization relationship: results_in_organization_of GO:0005886 ! plasma membrane [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "cytoplasm organisation" EXACT [] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005737 ! cytoplasm relationship: results_in_organization_of GO:0005737 ! cytoplasm [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005773 ! vacuole relationship: results_in_organization_of GO:0005773 ! vacuole [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: results_in_transport_to_from_or_in GO:0005773 ! vacuole relationship: results_in_transport_to_from_or_in GO:0005773 ! vacuole [Term] id: GO:0007039 name: protein catabolic process in the vacuole namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] synonym: "vacuolar protein breakdown" RELATED [] synonym: "vacuolar protein catabolic process" RELATED [] synonym: "vacuolar protein catabolism" RELATED [] synonym: "vacuolar protein degradation" RELATED [] is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_pir subset: goslim_plant synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007097 name: nuclear migration namespace: biological_process alt_id: GO:0040023 def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] synonym: "establishment of cell nucleus localization" RELATED [] synonym: "establishment of localization of nucleus" RELATED [] synonym: "establishment of nucleus localisation" RELATED [GOC:mah] synonym: "establishment of nucleus localization" RELATED [] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear movement" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus migration" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] is_a: GO:0046907 ! intracellular transport is_a: GO:0051647 ! nucleus localization is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: has_primary_input GO:0005634 ! nucleus [Term] id: GO:0007127 name: meiosis I namespace: biological_process def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] synonym: "meiosis I nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_I is_a: GO:0061982 ! meiosis I cell cycle process is_a: GO:0140013 ! meiotic nuclear division relationship: ends_during GO:0007134 ! meiotic telophase I [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] synonym: "meiosis II nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0061983 ! meiosis II cell cycle process is_a: GO:0140013 ! meiotic nuclear division [Term] id: GO:0008061 name: chitin binding namespace: molecular_function def: "Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] subset: goslim_drosophila is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0008104 name: protein localization namespace: biological_process alt_id: GO:0008105 alt_id: GO:0016249 alt_id: GO:0034613 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "cellular protein localization" EXACT [] synonym: "channel localizer activity" NARROW [GOC:mah] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] is_a: GO:0070727 ! cellular macromolecule localization intersection_of: GO:0051179 ! localization intersection_of: has_primary_input PR:000000001 ! protein relationship: has_primary_input PR:000000001 ! protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process is_a: BFO:0000015 ! process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24968" xsd:anyURI property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] synonym: "multicellular organism metabolic process" NARROW [] synonym: "single-organism metabolic process" RELATED [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase disjoint_from: GO:0051179 ! localization created_by: jl creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. subset: gocheck_do_not_annotate synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24680" xsd:anyURI [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function alt_id: GO:0070010 alt_id: GO:0070011 def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptidase activity, acting on D-amino acid peptides" NARROW [] synonym: "peptidase activity, acting on L-amino acid peptides" NARROW [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4.-.- xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl" xref: Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl" xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" xref: Reactome:R-HSA-5655483 "USP1 autocleavage" xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0009987 ! cellular process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008283 ! cell population proliferation relationship: positively_regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008283 ! cell population proliferation relationship: negatively_regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008299 name: isoprenoid biosynthetic process namespace: biological_process alt_id: GO:0009241 def: "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid anabolism" EXACT [] synonym: "isoprenoid biosynthesis" EXACT [] synonym: "isoprenoid formation" EXACT [] synonym: "isoprenoid synthesis" EXACT [] synonym: "polyisoprenoid anabolism" NARROW [] synonym: "polyisoprenoid biosynthesis" NARROW [] synonym: "polyisoprenoid biosynthetic process" NARROW [] synonym: "polyisoprenoid formation" NARROW [] synonym: "polyisoprenoid synthesis" NARROW [] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] xref: MetaCyc:POLYISOPRENSYN-PWY is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:18059 ! lipid relationship: has_primary_output CHEBI:18059 ! lipid [Term] id: GO:0008641 name: ubiquitin-like modifier activating enzyme activity namespace: molecular_function alt_id: GO:0008642 def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "small protein activating enzyme activity" NARROW [] is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds is_a: GO:0140096 ! catalytic activity, acting on a protein is_a: GO:0140657 ! ATP-dependent activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14208" xsd:anyURI [Term] id: GO:0008652 name: amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] synonym: "amino acid anabolism" EXACT [] synonym: "amino acid biosynthesis" EXACT [] synonym: "amino acid formation" EXACT [] synonym: "amino acid synthesis" EXACT [] synonym: "cellular amino acid biosynthetic process" EXACT [] xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:37022 ! amino-acid anion relationship: has_primary_output CHEBI:37022 ! amino-acid anion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_agr subset: goslim_chembl subset: goslim_plant synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] synonym: "multicellular organismal catabolic process" NARROW [] synonym: "single-organism catabolic process" RELATED [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process alt_id: GO:0043285 alt_id: GO:0044266 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule catabolic process" RELATED [] synonym: "cellular macromolecule catabolism" RELATED [] synonym: "cellular macromolecule degradation" RELATED [] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] synonym: "multicellular organismal macromolecule catabolic process" NARROW [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901575 ! organic substance catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:33694 ! biomacromolecule relationship: has_primary_input CHEBI:33694 ! biomacromolecule [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33694 ! biomacromolecule relationship: has_primary_output CHEBI:33694 ! biomacromolecule property_value: IAO:0000233 "http://amigo.geneontology.org/amigo/term/GO:0070589" xsd:anyURI [Term] id: GO:0009063 name: amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid breakdown" EXACT [] synonym: "amino acid catabolism" EXACT [] synonym: "amino acid degradation" EXACT [] synonym: "cellular amino acid catabolic process" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:37022 ! amino-acid anion relationship: has_primary_input CHEBI:37022 ! amino-acid anion property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI [Term] id: GO:0009066 name: aspartate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid metabolism" EXACT [] is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process [Term] id: GO:0009067 name: aspartate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid anabolism" EXACT [] synonym: "aspartate family amino acid biosynthesis" EXACT [] synonym: "aspartate family amino acid formation" EXACT [] synonym: "aspartate family amino acid synthesis" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:0170034 ! L-amino acid biosynthetic process is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process [Term] id: GO:0009085 name: lysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine anabolism" EXACT [] synonym: "lysine biosynthesis" EXACT [] synonym: "lysine formation" EXACT [] synonym: "lysine synthesis" EXACT [] xref: MetaCyc:PWY-5097 is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009112 name: nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] synonym: "nucleobase metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:18282 ! nucleobase relationship: has_primary_input_or_output CHEBI:18282 ! nucleobase [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell." [GOC:ai] synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell is_a: GO:0035592 ! establishment of protein localization to extracellular region intersection_of: GO:0046903 ! secretion intersection_of: has_primary_input PR:000000001 ! protein [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process alt_id: GO:0044106 def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] synonym: "cellular amine metabolic process" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:32952 ! amine relationship: has_primary_input_or_output CHEBI:32952 ! amine created_by: jl creation_date: 2009-07-15T11:55:44Z [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:32952 ! amine relationship: has_primary_output CHEBI:32952 ! amine [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:32952 ! amine relationship: has_primary_input CHEBI:32952 ! amine [Term] id: GO:0009403 name: toxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "toxin anabolism" EXACT [] synonym: "toxin biosynthesis" EXACT [] synonym: "toxin formation" EXACT [] synonym: "toxin synthesis" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process [Term] id: GO:0009404 name: toxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] subset: goslim_pir synonym: "toxin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_drosophila subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009626 name: plant-type hypersensitive response namespace: biological_process def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. synonym: "HR" BROAD [] synonym: "HR-PCD" EXACT [] synonym: "plant hypersensitive response" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034050 ! symbiont-induced defense-related programmed cell death is_a: GO:0045087 ! innate immune response [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009847 name: spore germination namespace: biological_process alt_id: GO:0075005 def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] synonym: "spore germination on or near host" NARROW [] is_a: GO:0048869 ! cellular developmental process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24413" xsd:anyURI [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009058 ! biosynthetic process relationship: regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009058 ! biosynthetic process relationship: negatively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009058 ! biosynthetic process relationship: positively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process alt_id: GO:0044252 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008152 ! metabolic process relationship: negatively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process alt_id: GO:0044253 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008152 ! metabolic process relationship: positively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009056 ! catabolic process relationship: regulates GO:0009056 ! catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009056 ! catabolic process relationship: negatively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009056 ! catabolic process relationship: positively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0044763 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: jl creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] subset: goslim_drosophila synonym: "endomembrane organization" EXACT [] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0012505 ! endomembrane system relationship: results_in_organization_of GO:0012505 ! endomembrane system [Term] id: GO:0010324 name: membrane invagination namespace: biological_process alt_id: GO:1902534 def: "The infolding of a membrane." [GOC:tb] subset: goslim_yeast synonym: "single-organism membrane invagination" RELATED [] is_a: GO:0061024 ! membrane organization created_by: jl creation_date: 2013-12-02T13:58:34Z [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. synonym: "gene regulation" RELATED [GOC:cjm] synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010467 ! gene expression relationship: regulates GO:0010467 ! gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI [Term] id: GO:0010549 name: regulation of membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030397 ! membrane disassembly relationship: regulates GO:0030397 ! membrane disassembly [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process relationship: regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006793 ! phosphorus metabolic process relationship: positively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006793 ! phosphorus metabolic process relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022402 ! cell cycle process relationship: regulates GO:0022402 ! cell cycle process [Term] id: GO:0010565 name: regulation of cellular ketone metabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042180 ! cellular ketone metabolic process relationship: regulates GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0010566 name: regulation of ketone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042181 ! ketone biosynthetic process relationship: regulates GO:0042181 ! ketone biosynthetic process [Term] id: GO:0010567 name: regulation of ketone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042182 ! ketone catabolic process relationship: regulates GO:0042182 ! ketone catabolic process [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043170 ! macromolecule metabolic process relationship: positively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043170 ! macromolecule metabolic process relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010608 name: post-transcriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] synonym: "posttranscriptional regulation of gene expression" EXACT [] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010467 ! gene expression relationship: positively_regulates GO:0010467 ! gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. synonym: "gene silencing" RELATED [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010467 ! gene expression relationship: negatively_regulates GO:0010467 ! gene expression property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006996 ! organelle organization relationship: positively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006996 ! organelle organization relationship: negatively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010876 name: lipid localization namespace: biological_process def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] synonym: "lipid localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: has_primary_input CHEBI:18059 ! lipid relationship: has_primary_input CHEBI:18059 ! lipid [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032989 ! cellular anatomical entity morphogenesis [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0022402 ! cell cycle process relationship: negatively_regulates GO:0022402 ! cell cycle process created_by: tb creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010966 name: regulation of phosphate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006817 ! phosphate ion transport relationship: regulates GO:0006817 ! phosphate ion transport created_by: tb creation_date: 2009-05-20T11:42:50Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_prokaryote synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24835" xsd:anyURI [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane relationship: part_of CL:0000000 ! cell [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0031982 ! vesicle relationship: part_of GO:0031982 ! vesicle [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input PR:000000001 ! protein [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:24834 ! inorganic anion relationship: has_primary_input CHEBI:24834 ! inorganic anion [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:25696 ! organic anion relationship: has_primary_input CHEBI:25696 ! organic anion [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:16670 ! peptide relationship: has_primary_input CHEBI:16670 ! peptide [Term] id: GO:0015837 name: amine transport namespace: biological_process def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "amine/polyamine transport" RELATED [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:32952 ! amine relationship: has_primary_input CHEBI:32952 ! amine [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:64709 ! organic acid relationship: has_primary_input CHEBI:64709 ! organic acid [Term] id: GO:0015851 name: nucleobase transport namespace: biological_process def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:18282 ! nucleobase relationship: has_primary_input CHEBI:18282 ! nucleobase [Term] id: GO:0015931 name: nucleobase-containing compound transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity [Term] id: GO:0016020 name: membrane namespace: cellular_component alt_id: GO:0016021 alt_id: GO:0098589 alt_id: GO:0098805 def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "integral component of membrane" NARROW [] synonym: "integral to membrane" NARROW [] synonym: "membrane region" NARROW [] synonym: "region of membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] synonym: "whole membrane" NARROW [] xref: Wikipedia:Biological_membrane xref: Wikipedia:Transmembrane_protein is_a: GO:0110165 ! cellular anatomical entity creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0016042 name: lipid catabolic process namespace: biological_process alt_id: GO:0006724 alt_id: GO:0044240 def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid breakdown" EXACT [] synonym: "lipid catabolism" EXACT [] synonym: "lipid degradation" EXACT [] synonym: "lipolysis" EXACT [] synonym: "multicellular organism lipid catabolic process" NARROW [] synonym: "multicellular organismal lipid catabolic process" NARROW [] xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901575 ! organic substance catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:18059 ! lipid relationship: has_primary_input CHEBI:18059 ! lipid [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis intersection_of: GO:0009987 ! cellular process intersection_of: results_in_organization_of GO:0005575 ! cellular_component relationship: results_in_organization_of GO:0005575 ! cellular_component [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0031982 ! vesicle relationship: results_in_organization_of GO:0031982 ! vesicle [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:64709 ! organic acid relationship: has_primary_output CHEBI:64709 ! organic acid [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:64709 ! organic acid relationship: has_primary_input CHEBI:64709 ! organic acid [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: prokaryote_subset synonym: "RNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:33697 ! ribonucleic acid relationship: has_primary_input_or_output CHEBI:33697 ! ribonucleic acid [Term] id: GO:0016106 name: sesquiterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid anabolism" EXACT [] synonym: "sesquiterpenoid biosynthesis" EXACT [] synonym: "sesquiterpenoid formation" EXACT [] synonym: "sesquiterpenoid synthesis" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016114 name: terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid anabolism" EXACT [] synonym: "terpenoid biosynthesis" EXACT [] synonym: "terpenoid formation" EXACT [] synonym: "terpenoid synthesis" EXACT [] xref: Wikipedia:Terpenoid is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: process_has_causal_agent GO:0031982 ! vesicle relationship: process_has_causal_agent GO:0031982 ! vesicle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25421" xsd:anyURI [Term] id: GO:0016236 name: macroautophagy namespace: biological_process alt_id: GO:0034262 def: "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] synonym: "autophagy" BROAD [] synonym: "selective autophagy" NARROW [] is_a: GO:0006914 ! autophagy property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26115" xsd:anyURI [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016462 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast subset: prokaryote_subset xref: EC:2.-.-.- xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016746 name: acyltransferase activity namespace: molecular_function alt_id: GO:0008415 def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila synonym: "transferase activity, transferring acyl groups" EXACT [] xref: EC:2.3.-.- xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" xref: Reactome:R-HSA-6792572 "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs" xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" is_a: GO:0016740 ! transferase activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20486" xsd:anyURI [Term] id: GO:0016755 name: aminoacyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "transferase activity, transferring amino-acyl groups" EXACT [] xref: EC:2.3.2.- is_a: GO:0016746 ! acyltransferase activity [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7.-.- is_a: GO:0016740 ! transferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast xref: EC:3.-.-.- xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2.-.- xref: Reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan" xref: Reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016817 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6.-.- is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016818 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] xref: EC:3.6.1.- xref: Reactome:R-HSA-9731590 "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP" xref: Reactome:R-HSA-9731613 "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP" xref: Reactome:R-HSA-9731632 "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP" is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6.-.-.- is_a: GO:0003824 ! catalytic activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19380" xsd:anyURI [Term] id: GO:0016877 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.-.-, GOC:mah] synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2.-.- is_a: GO:0016874 ! ligase activity [Term] id: GO:0016887 name: ATP hydrolysis activity namespace: molecular_function alt_id: GO:0004002 alt_id: GO:0042623 def: "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function. synonym: "adenosine 5'-triphosphatase activity" EXACT [] synonym: "adenosine triphosphatase activity" EXACT [] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [] synonym: "ATP monophosphatase activity" RELATED [] synonym: "ATP phosphohydrolase activity" EXACT [] xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70" xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse" xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90" xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE" xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER" xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex" xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" xref: Reactome:R-HSA-917693 "ESCRT Disassembly" xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope" xref: Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP" xref: Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex" xref: RHEA:13065 is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity relationship: part_of GO:0140657 ! ATP-dependent activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19078" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20498" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI [Term] id: GO:0017111 name: ribonucleoside triphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [] synonym: "nucleoside 5-triphosphatase activity" BROAD [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" BROAD [] synonym: "nucleoside triphosphate hydrolase activity" BROAD [] synonym: "nucleoside triphosphate phosphatase activity" BROAD [] synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-triphosphatase activity" BROAD [] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" xref: RHEA:23680 is_a: GO:0016462 ! pyrophosphatase activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21232" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23401" xsd:anyURI [Term] id: GO:0017148 name: negative regulation of translation namespace: biological_process alt_id: GO:0016478 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] synonym: "down regulation of protein biosynthetic process" EXACT [] synonym: "down-regulation of protein biosynthetic process" EXACT [] synonym: "downregulation of protein biosynthetic process" EXACT [] synonym: "inhibition of protein biosynthetic process" NARROW [] synonym: "negative regulation of protein anabolism" EXACT [] synonym: "negative regulation of protein biosynthesis" EXACT [] synonym: "negative regulation of protein biosynthetic process" EXACT [] synonym: "negative regulation of protein formation" EXACT [] synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of amide metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006412 ! translation relationship: negatively_regulates GO:0006412 ! translation [Term] id: GO:0017157 name: regulation of exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006887 ! exocytosis relationship: regulates GO:0006887 ! exocytosis [Term] id: GO:0018130 name: heterocycle biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] synonym: "heterocycle anabolism" EXACT [] synonym: "heterocycle biosynthesis" EXACT [] synonym: "heterocycle formation" EXACT [] synonym: "heterocycle synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:5686 ! heterocyclic compound relationship: has_primary_output CHEBI:5686 ! heterocyclic compound [Term] id: GO:0018904 name: ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [GOC:pr, ISBN:0198506732] subset: goslim_pir synonym: "ether metabolism" EXACT [] synonym: "organic ether metabolic process" EXACT [] synonym: "organic ether metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018995 name: host cellular component namespace: cellular_component def: "Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732] synonym: "host organism" EXACT [] xref: Wikipedia:Host_(biology) is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "regulation of lipid metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006629 ! lipid metabolic process relationship: regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008152 ! metabolic process relationship: regulates GO:0008152 ! metabolic process [Term] id: GO:0019438 name: aromatic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound anabolism" EXACT [] synonym: "aromatic compound biosynthesis" EXACT [] synonym: "aromatic compound formation" EXACT [] synonym: "aromatic compound synthesis" EXACT [] synonym: "aromatic hydrocarbon biosynthesis" NARROW [] synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33655 ! aromatic compound relationship: has_primary_output CHEBI:33655 ! aromatic compound [Term] id: GO:0019439 name: aromatic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound breakdown" EXACT [] synonym: "aromatic compound catabolism" EXACT [] synonym: "aromatic compound degradation" EXACT [] synonym: "aromatic hydrocarbon catabolic process" NARROW [] synonym: "aromatic hydrocarbon catabolism" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044248 ! cellular catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:33655 ! aromatic compound relationship: has_primary_input CHEBI:33655 ! aromatic compound [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 alt_id: GO:0044267 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "cellular protein metabolic process" EXACT [] synonym: "cellular protein metabolism" EXACT [] synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output PR:000000001 ! protein relationship: has_primary_input_or_output PR:000000001 ! protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_pombe synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019751 name: polyol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [PMID:30240188] synonym: "polyhydric alcohol metabolic process" EXACT [] synonym: "polyol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "carboxylic acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:29067 ! carboxylic acid anion relationship: has_primary_input_or_output CHEBI:29067 ! carboxylic acid anion [Term] id: GO:0019755 name: one-carbon compound transport namespace: biological_process def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "one carbon compound transport" EXACT [] is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:64708 ! one-carbon compound relationship: has_primary_input CHEBI:64708 ! one-carbon compound [Term] id: GO:0019777 name: Atg12 transferase activity namespace: molecular_function def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404] synonym: "APG12 conjugating enzyme activity" NARROW [] synonym: "APG12 ligase activity" NARROW [] synonym: "Atg12 conjugating enzyme activity" NARROW [] synonym: "Atg12 ligase activity" NARROW [] xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019778 name: Atg12 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG12 activating enzyme activity" RELATED [GOC:vw] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019786 name: protein-phosphatidylethanolamide deconjugating activity namespace: molecular_function def: "Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328] synonym: "APG8-PE hydrolase" RELATED [] synonym: "APG8-specific protease activity" NARROW [GOC:vw] synonym: "ATG8-PE deconjugation activity" NARROW [] synonym: "ATG8-PE hydrolase activity" NARROW [] synonym: "Atg8-specific peptidase activity" NARROW [] synonym: "Atg8-specific protease activity" EXACT [] is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25472" xsd:anyURI [Term] id: GO:0019787 name: ubiquitin-like protein transferase activity namespace: molecular_function alt_id: GO:0008639 alt_id: GO:0008640 def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: goslim_drosophila subset: goslim_pir synonym: "E2" BROAD [] synonym: "E3" RELATED [GOC:dph] synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] synonym: "small protein conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE" xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated" is_a: GO:0016755 ! aminoacyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24697" xsd:anyURI [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] subset: goslim_chembl synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0009987 ! cellular process [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22929" xsd:anyURI [Term] id: GO:0019954 name: asexual reproduction namespace: biological_process def: "A type of reproduction in which new individuals are produced from a single organism, either from an unfertilized egg or from a single cell or group of cells." [ISBN:0387520546, PMID:22977071, PMID:28779329, PMID:29559496] synonym: "parthenogenesis" RELATED [Wikipedia:Parthenogenesis] xref: Wikipedia:Asexual_reproduction is_a: GO:0000003 ! reproduction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22929" xsd:anyURI [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: results_in_disassembly_of GO:0005575 ! cellular_component disjoint_from: GO:0022607 ! cellular component assembly relationship: results_in_disassembly_of GO:0005575 ! cellular_component [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0044702 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] subset: goslim_generic synonym: "single organism reproductive process" RELATED [] is_a: GO:0008150 ! biological_process intersection_of: GO:0008150 ! biological_process intersection_of: part_of GO:0000003 ! reproduction disjoint_from: GO:0044848 ! biological phase relationship: part_of GO:0000003 ! reproduction created_by: jl creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: results_in_assembly_of GO:0005575 ! cellular_component relationship: part_of GO:0044085 ! cellular component biogenesis relationship: results_in_assembly_of GO:0005575 ! cellular_component [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0022618 name: protein-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl synonym: "ribonucleoprotein complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis relationship: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0030100 name: regulation of endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006897 ! endocytosis relationship: regulates GO:0006897 ! endocytosis [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" RELATED [] xref: NIF_Subcellular:sao885490876 is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process alt_id: GO:0044254 alt_id: GO:0044257 def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_candida subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: prokaryote_subset synonym: "cellular protein breakdown" EXACT [] synonym: "cellular protein catabolic process" EXACT [] synonym: "cellular protein catabolism" EXACT [] synonym: "cellular protein degradation" EXACT [] synonym: "multicellular organismal protein catabolic process" NARROW [] synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input PR:000000001 ! protein relationship: has_primary_input PR:000000001 ! protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0030247 name: polysaccharide binding namespace: molecular_function alt_id: GO:0002506 def: "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah] synonym: "polysaccharide assembly with MHC class II protein complex" NARROW [] is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0030397 name: membrane disassembly namespace: biological_process def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] synonym: "membrane breakdown" EXACT [] synonym: "membrane catabolism" EXACT [] synonym: "membrane degradation" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:0016020 ! membrane relationship: results_in_disassembly_of GO:0016020 ! membrane [Term] id: GO:0030428 name: cell septum namespace: cellular_component def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] subset: goslim_pir synonym: "cross wall" EXACT [] synonym: "septum" BROAD [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0030435 name: sporulation resulting in formation of a cellular spore namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] synonym: "spore biosynthesis" EXACT [] synonym: "spore differentiation" EXACT [] synonym: "spore formation" EXACT [] xref: Wikipedia:Sporogenesis is_a: GO:0043934 ! sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24410" xsd:anyURI [Term] id: GO:0030436 name: asexual sporulation namespace: biological_process def: "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi." [GOC:mah, PMID:9529886] synonym: "asexual reproductive sporulation" EXACT [] synonym: "asexual spore formation" EXACT [] synonym: "mitotic spore formation" EXACT [] synonym: "mitotic sporulation" EXACT [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0043934 ! sporulation property_value: RO:0002161 NCBITaxon:33083 [Term] id: GO:0030447 name: filamentous growth namespace: biological_process def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] subset: goslim_candida is_a: GO:0040007 ! growth [Term] id: GO:0030448 name: hyphal growth namespace: biological_process alt_id: GO:0075061 def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] subset: goslim_candida synonym: "formation of symbiont invasive hypha in host" EXACT [] synonym: "formation of symbiont invasive hypha within host" EXACT [] synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT [] synonym: "invasive hyphal growth" EXACT [] synonym: "symbiont invasive hypha formation within host" EXACT [] is_a: GO:0030447 ! filamentous growth property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19013" xsd:anyURI [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] is_a: GO:0012506 ! vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031323 name: regulation of cellular metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gocheck_do_not_annotate synonym: "regulation of cellular metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044237 ! cellular metabolic process relationship: regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031324 name: negative regulation of cellular metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gocheck_do_not_annotate synonym: "down regulation of cellular metabolic process" EXACT [] synonym: "down-regulation of cellular metabolic process" EXACT [] synonym: "downregulation of cellular metabolic process" EXACT [] synonym: "inhibition of cellular metabolic process" NARROW [] synonym: "negative regulation of cellular metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process relationship: negatively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gocheck_do_not_annotate synonym: "activation of cellular metabolic process" NARROW [] synonym: "positive regulation of cellular metabolism" EXACT [] synonym: "stimulation of cellular metabolic process" NARROW [] synonym: "up regulation of cellular metabolic process" EXACT [] synonym: "up-regulation of cellular metabolic process" EXACT [] synonym: "upregulation of cellular metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044237 ! cellular metabolic process relationship: positively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031326 name: regulation of cellular biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular anabolism" EXACT [] synonym: "regulation of cellular biosynthesis" EXACT [] synonym: "regulation of cellular formation" EXACT [] synonym: "regulation of cellular synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044249 ! cellular biosynthetic process relationship: regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031327 name: negative regulation of cellular biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular biosynthetic process" EXACT [] synonym: "down-regulation of cellular biosynthetic process" EXACT [] synonym: "downregulation of cellular biosynthetic process" EXACT [] synonym: "inhibition of cellular biosynthetic process" NARROW [] synonym: "negative regulation of cellular anabolism" EXACT [] synonym: "negative regulation of cellular biosynthesis" EXACT [] synonym: "negative regulation of cellular formation" EXACT [] synonym: "negative regulation of cellular synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031328 name: positive regulation of cellular biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular biosynthetic process" NARROW [] synonym: "positive regulation of cellular anabolism" EXACT [] synonym: "positive regulation of cellular biosynthesis" EXACT [] synonym: "positive regulation of cellular formation" EXACT [] synonym: "positive regulation of cellular synthesis" EXACT [] synonym: "stimulation of cellular biosynthetic process" NARROW [] synonym: "up regulation of cellular biosynthetic process" EXACT [] synonym: "up-regulation of cellular biosynthetic process" EXACT [] synonym: "upregulation of cellular biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process relationship: positively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031329 name: regulation of cellular catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular breakdown" EXACT [] synonym: "regulation of cellular catabolism" EXACT [] synonym: "regulation of cellular degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044248 ! cellular catabolic process relationship: regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031330 name: negative regulation of cellular catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular catabolic process" EXACT [] synonym: "down-regulation of cellular catabolic process" EXACT [] synonym: "downregulation of cellular catabolic process" EXACT [] synonym: "inhibition of cellular catabolic process" NARROW [] synonym: "negative regulation of cellular breakdown" EXACT [] synonym: "negative regulation of cellular catabolism" EXACT [] synonym: "negative regulation of cellular degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044248 ! cellular catabolic process relationship: negatively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031331 name: positive regulation of cellular catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular catabolic process" NARROW [] synonym: "positive regulation of cellular breakdown" EXACT [] synonym: "positive regulation of cellular catabolism" EXACT [] synonym: "positive regulation of cellular degradation" EXACT [] synonym: "stimulation of cellular catabolic process" NARROW [] synonym: "up regulation of cellular catabolic process" EXACT [] synonym: "up-regulation of cellular catabolic process" EXACT [] synonym: "upregulation of cellular catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044248 ! cellular catabolic process relationship: positively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031333 name: negative regulation of protein-containing complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] synonym: "negative regulation of protein complex assembly" RELATED [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0065003 ! protein-containing complex assembly relationship: negatively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031334 name: positive regulation of protein-containing complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "activation of protein complex assembly" NARROW [] synonym: "positive regulation of protein complex assembly" RELATED [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0065003 ! protein-containing complex assembly relationship: positively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031338 name: regulation of vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006906 ! vesicle fusion relationship: regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031339 name: negative regulation of vesicle fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "down regulation of vesicle fusion" EXACT [] synonym: "down-regulation of vesicle fusion" EXACT [] synonym: "downregulation of vesicle fusion" EXACT [] synonym: "inhibition of vesicle fusion" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006906 ! vesicle fusion relationship: negatively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031340 name: positive regulation of vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "activation of vesicle fusion" NARROW [] synonym: "stimulation of vesicle fusion" NARROW [] synonym: "up regulation of vesicle fusion" EXACT [] synonym: "up-regulation of vesicle fusion" EXACT [] synonym: "upregulation of vesicle fusion" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006906 ! vesicle fusion relationship: positively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0097708 ! intracellular vesicle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process alt_id: GO:0034629 def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "cellular protein complex localisation" RELATED [GOC:mah] synonym: "cellular protein complex localization" RELATED [] synonym: "cellular protein-containing complex localization" RELATED [] synonym: "establishment and maintenance of cellular protein complex localization" RELATED [] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: has_primary_input GO:0032991 ! protein-containing complex relationship: has_primary_input GO:0032991 ! protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: goslim_mouse is_a: GO:0031975 ! envelope relationship: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0031975 name: envelope namespace: cellular_component def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of CL:0000000 ! cell [Term] id: GO:0031982 name: vesicle namespace: cellular_component alt_id: GO:0031988 def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0032179 name: germ tube namespace: cellular_component def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] subset: goslim_pir xref: Wikipedia:Germ_tube is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0032239 name: regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015931 ! nucleobase-containing compound transport relationship: regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032240 name: negative regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0015931 ! nucleobase-containing compound transport relationship: negatively_regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032241 name: positive regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0015931 ! nucleobase-containing compound transport relationship: positively_regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032365 name: intracellular lipid transport namespace: biological_process def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:18059 ! lipid intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure [Term] id: GO:0032368 name: regulation of lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006869 ! lipid transport relationship: regulates GO:0006869 ! lipid transport [Term] id: GO:0032369 name: negative regulation of lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of lipid transport" EXACT [] synonym: "down-regulation of lipid transport" EXACT [] synonym: "downregulation of lipid transport" EXACT [] synonym: "inhibition of lipid transport" NARROW [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051051 ! negative regulation of transport is_a: GO:1905953 ! negative regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006869 ! lipid transport relationship: negatively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032370 name: positive regulation of lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of lipid transport" NARROW [] synonym: "stimulation of lipid transport" NARROW [] synonym: "up regulation of lipid transport" EXACT [] synonym: "up-regulation of lipid transport" EXACT [] synonym: "upregulation of lipid transport" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:1905954 ! positive regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006869 ! lipid transport relationship: positively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032377 name: regulation of intracellular lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032365 ! intracellular lipid transport relationship: regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032378 name: negative regulation of intracellular lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "down regulation of intracellular lipid transport" EXACT [] synonym: "down-regulation of intracellular lipid transport" EXACT [] synonym: "downregulation of intracellular lipid transport" EXACT [] synonym: "inhibition of intracellular lipid transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032387 ! negative regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032365 ! intracellular lipid transport relationship: negatively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032379 name: positive regulation of intracellular lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "activation of intracellular lipid transport" NARROW [] synonym: "stimulation of intracellular lipid transport" NARROW [] synonym: "up regulation of intracellular lipid transport" EXACT [] synonym: "up-regulation of intracellular lipid transport" EXACT [] synonym: "upregulation of intracellular lipid transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032388 ! positive regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032365 ! intracellular lipid transport relationship: positively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0046907 ! intracellular transport relationship: regulates GO:0046907 ! intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0046907 ! intracellular transport relationship: negatively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0046907 ! intracellular transport relationship: positively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032409 name: regulation of transporter activity namespace: biological_process def: "Any process that modulates the activity of a transporter." [GOC:mah] subset: term_scheduled_for_obsoletion is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005215 ! transporter activity relationship: regulates GO:0005215 ! transporter activity [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] subset: term_scheduled_for_obsoletion synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0005215 ! transporter activity relationship: negatively_regulates GO:0005215 ! transporter activity [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] subset: term_scheduled_for_obsoletion synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0005215 ! transporter activity relationship: positively_regulates GO:0005215 ! transporter activity [Term] id: GO:0032502 name: developmental process namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: jl creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0061024 ! membrane organization intersection_of: GO:0015031 ! protein transport intersection_of: occurs_in GO:0016020 ! membrane relationship: occurs_in GO:0016020 ! membrane [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process alt_id: GO:0062103 def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. subset: gocheck_do_not_annotate synonym: "double-stranded RNA biosynthesis" NARROW [] synonym: "double-stranded RNA biosynthetic process" NARROW [] synonym: "dsRNA biosynthesis" NARROW [] synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl] synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33697 ! ribonucleic acid relationship: has_primary_output CHEBI:33697 ! ribonucleic acid [Term] id: GO:0032871 name: regulation of karyogamy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] is_a: GO:1903353 ! regulation of nucleus organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000741 ! karyogamy relationship: regulates GO:0000741 ! karyogamy [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051179 ! localization relationship: regulates GO:0051179 ! localization [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process alt_id: GO:1903827 def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein localization" EXACT [] synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008104 ! protein localization relationship: regulates GO:0008104 ! protein localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI created_by: jl creation_date: 2015-01-20T14:32:14Z [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015849 ! organic acid transport relationship: regulates GO:0015849 ! organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0015849 ! organic acid transport relationship: negatively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0015849 ! organic acid transport relationship: positively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0046903 ! secretion is_a: GO:0140352 ! export from cell [Term] id: GO:0032984 name: protein-containing complex disassembly namespace: biological_process alt_id: GO:0034623 alt_id: GO:0043241 alt_id: GO:0043624 def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] synonym: "cellular macromolecule complex disassembly" RELATED [] synonym: "cellular protein complex disassembly" RELATED [] synonym: "macromolecule complex disassembly" RELATED [] synonym: "protein complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:0032991 ! protein-containing complex relationship: results_in_disassembly_of GO:0032991 ! protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI [Term] id: GO:0032988 name: protein-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "ribonucleoprotein complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:1990904 ! ribonucleoprotein complex relationship: results_in_disassembly_of GO:1990904 ! ribonucleoprotein complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25143" xsd:anyURI [Term] id: GO:0032989 name: cellular anatomical entity morphogenesis namespace: biological_process def: "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular component morphogenesis" EXACT [] synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25496" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26249" xsd:anyURI [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component is_a: PR:000050567 ! protein-containing material entity disjoint_from: GO:0110165 ! cellular anatomical entity [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033037 name: polysaccharide localization namespace: biological_process def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006996 ! organelle organization relationship: regulates GO:0006996 ! organelle organization [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] is_a: GO:0009987 ! cellular process is_a: GO:0043473 ! pigmentation [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006886 ! intracellular protein transport relationship: regulates GO:0006886 ! intracellular protein transport [Term] id: GO:0033238 name: regulation of amine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah] synonym: "regulation of amine metabolism" EXACT [] synonym: "regulation of cellular amine metabolic process" EXACT [] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009308 ! amine metabolic process relationship: regulates GO:0009308 ! amine metabolic process [Term] id: GO:0033239 name: negative regulation of amine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "negative regulation of amine metabolism" EXACT [] synonym: "negative regulation of cellular amine metabolic process" EXACT [] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009308 ! amine metabolic process relationship: negatively_regulates GO:0009308 ! amine metabolic process [Term] id: GO:0033240 name: positive regulation of amine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "positive regulation of amine metabolism" EXACT [] synonym: "positive regulation of cellular amine metabolic process" EXACT [] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009308 ! amine metabolic process relationship: positively_regulates GO:0009308 ! amine metabolic process [Term] id: GO:0033241 name: regulation of amine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "regulation of amine breakdown" EXACT [] synonym: "regulation of amine catabolism" EXACT [] synonym: "regulation of amine degradation" EXACT [] synonym: "regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009310 ! amine catabolic process relationship: regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033242 name: negative regulation of amine catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "negative regulation of amine breakdown" EXACT [] synonym: "negative regulation of amine catabolism" EXACT [] synonym: "negative regulation of amine degradation" EXACT [] synonym: "negative regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009310 ! amine catabolic process relationship: negatively_regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033243 name: positive regulation of amine catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "positive regulation of amine breakdown" EXACT [] synonym: "positive regulation of amine catabolism" EXACT [] synonym: "positive regulation of amine degradation" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009310 ! amine catabolic process relationship: positively_regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0043226 ! organelle relationship: has_target_end_location GO:0043226 ! organelle [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0033673 name: negative regulation of kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] subset: term_scheduled_for_obsoletion synonym: "down regulation of kinase activity" EXACT [] synonym: "down-regulation of kinase activity" EXACT [] synonym: "downregulation of kinase activity" EXACT [] synonym: "inhibition of kinase activity" NARROW [] synonym: "kinase inhibitor" NARROW [] is_a: GO:0042326 ! negative regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051348 ! negative regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016301 ! kinase activity relationship: negatively_regulates GO:0016301 ! kinase activity [Term] id: GO:0033674 name: positive regulation of kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] subset: term_scheduled_for_obsoletion synonym: "kinase activator" NARROW [] synonym: "stimulation of kinase activity" NARROW [] synonym: "up regulation of kinase activity" EXACT [] synonym: "up-regulation of kinase activity" EXACT [] synonym: "upregulation of kinase activity" EXACT [] is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051347 ! positive regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016301 ! kinase activity relationship: positively_regulates GO:0016301 ! kinase activity [Term] id: GO:0034050 name: symbiont-induced defense-related programmed cell death namespace: biological_process def: "Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules." [GOC:pamgo_curators] comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'symbiont-mediated activation of host programmed cell death' ; GO:0052042'. synonym: "host programmed cell death induced by symbiont" EXACT [] synonym: "programmed cell death induced by symbiont" EXACT [] is_a: GO:0012501 ! programmed cell death is_a: GO:0140546 ! defense response to symbiont property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20255" xsd:anyURI [Term] id: GO:0034248 name: regulation of amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] synonym: "regulation of cellular amide metabolic process" EXACT [] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043603 ! amide metabolic process relationship: regulates GO:0043603 ! amide metabolic process [Term] id: GO:0034249 name: negative regulation of amide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "negative regulation of amide metabolism" EXACT [] synonym: "negative regulation of cellular amide metabolic process" EXACT [] is_a: GO:0034248 ! regulation of amide metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043603 ! amide metabolic process relationship: negatively_regulates GO:0043603 ! amide metabolic process [Term] id: GO:0034250 name: positive regulation of amide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "positive regulation of amide metabolism" EXACT [] synonym: "positive regulation of cellular amide metabolic process" EXACT [] is_a: GO:0034248 ! regulation of amide metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043603 ! amide metabolic process relationship: positively_regulates GO:0043603 ! amide metabolic process [Term] id: GO:0034251 name: regulation of amide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "regulation of amide breakdown" EXACT [] synonym: "regulation of amide catabolism" EXACT [] synonym: "regulation of amide degradation" EXACT [] synonym: "regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043605 ! amide catabolic process relationship: regulates GO:0043605 ! amide catabolic process [Term] id: GO:0034252 name: negative regulation of amide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "negative regulation of amide breakdown" EXACT [] synonym: "negative regulation of amide catabolism" EXACT [] synonym: "negative regulation of amide degradation" RELATED [] synonym: "negative regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0034249 ! negative regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043605 ! amide catabolic process relationship: negatively_regulates GO:0043605 ! amide catabolic process [Term] id: GO:0034253 name: positive regulation of amide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "positive regulation of amide breakdown" EXACT [] synonym: "positive regulation of amide catabolism" EXACT [] synonym: "positive regulation of amide degradation" RELATED [] synonym: "positive regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0034250 ! positive regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043605 ! amide catabolic process relationship: positively_regulates GO:0043605 ! amide catabolic process [Term] id: GO:0034293 name: sexual sporulation namespace: biological_process def: "The formation of spores derived from the products of meiosis." [GOC:mah] synonym: "meiotic spore formation" EXACT [] synonym: "meiotic sporulation" EXACT [] synonym: "sexual spore formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0043934 ! sporulation intersection_of: GO:0043934 ! sporulation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle property_value: RO:0002161 NCBITaxon:33083 [Term] id: GO:0034301 name: endospore formation namespace: biological_process def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034308 name: primary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol metabolic process" EXACT [] synonym: "primary alcohol metabolism" EXACT [GOC:mah] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0034309 name: primary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol biosynthetic process" EXACT [] synonym: "primary alcohol anabolism" EXACT [GOC:mah] synonym: "primary alcohol biosynthesis" EXACT [GOC:mah] synonym: "primary alcohol formation" EXACT [GOC:mah] synonym: "primary alcohol synthesis" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0034504 name: protein localization to nucleus namespace: biological_process alt_id: GO:0044744 def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] synonym: "protein localisation to nucleus" EXACT [GOC:mah] synonym: "protein localization in cell nucleus" EXACT [] synonym: "protein localization in nucleus" EXACT [GOC:mah] synonym: "protein targeting to nucleus" RELATED [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0005634 ! nucleus relationship: has_target_end_location GO:0005634 ! nucleus creation_date: 2012-11-07T15:45:54Z [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_chembl synonym: "cellular nitrogen compound metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_primary_output CHEBI:61120 ! nucleobase-containing molecular entity [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_chembl synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity [Term] id: GO:0035592 name: establishment of protein localization to extracellular region namespace: biological_process def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] synonym: "establishment of protein localization in extracellular region" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071692 ! protein localization to extracellular region intersection_of: GO:0045184 ! establishment of protein localization intersection_of: has_target_end_location GO:0005576 ! extracellular region created_by: bf creation_date: 2010-11-09T10:25:08Z [Term] id: GO:0036094 name: small molecule binding namespace: molecular_function def: "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_agr subset: goslim_flybase_ribbon is_a: GO:0005488 ! binding created_by: bf creation_date: 2012-01-17T04:20:34Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process alt_id: GO:0006464 def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote synonym: "cellular protein modification process" EXACT [] synonym: "process resulting in protein modification" EXACT [] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI created_by: bf creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0040020 name: regulation of meiotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] synonym: "regulation of meiosis" BROAD [GOC:vw] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0140013 ! meiotic nuclear division relationship: regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0042127 name: regulation of cell population proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] synonym: "regulation of cell proliferation" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008283 ! cell population proliferation relationship: regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042176 name: regulation of protein catabolic process namespace: biological_process alt_id: GO:1903362 alt_id: GO:2000598 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolic process" EXACT [] synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "regulation of cyclin catabolic process" NARROW [] synonym: "regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "regulation of cyclin degradation" NARROW [GOC:obol] synonym: "regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "regulation of protein breakdown" EXACT [] synonym: "regulation of protein catabolism" EXACT [] synonym: "regulation of protein degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030163 ! protein catabolic process relationship: regulates GO:0030163 ! protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI created_by: kmv creation_date: 2014-08-21T15:05:45Z [Term] id: GO:0042177 name: negative regulation of protein catabolic process namespace: biological_process alt_id: GO:1903363 alt_id: GO:2000599 def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of protein catabolic process" EXACT [] synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein catabolic process" EXACT [] synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein catabolic process" EXACT [] synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of protein catabolic process" NARROW [] synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolic process" EXACT [] synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein breakdown" EXACT [] synonym: "negative regulation of protein catabolism" EXACT [] synonym: "negative regulation of protein degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030163 ! protein catabolic process relationship: negatively_regulates GO:0030163 ! protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0042180 name: cellular ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] subset: goslim_pir synonym: "ketone metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:17087 ! ketone relationship: has_primary_input_or_output CHEBI:17087 ! ketone [Term] id: GO:0042181 name: ketone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone anabolism" EXACT [] synonym: "ketone biosynthesis" EXACT [] synonym: "ketone formation" EXACT [] synonym: "ketone synthesis" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:17087 ! ketone relationship: has_primary_output CHEBI:17087 ! ketone [Term] id: GO:0042182 name: ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone breakdown" EXACT [] synonym: "ketone catabolism" EXACT [] synonym: "ketone degradation" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:17087 ! ketone relationship: has_primary_input CHEBI:17087 ! ketone [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016310 ! phosphorylation relationship: regulates GO:0016310 ! phosphorylation [Term] id: GO:0042326 name: negative regulation of phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] synonym: "down regulation of phosphorylation" EXACT [] synonym: "down-regulation of phosphorylation" EXACT [] synonym: "downregulation of phosphorylation" EXACT [] synonym: "inhibition of phosphorylation" NARROW [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016310 ! phosphorylation relationship: negatively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042327 name: positive regulation of phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] synonym: "activation of phosphorylation" NARROW [] synonym: "stimulation of phosphorylation" NARROW [] synonym: "up regulation of phosphorylation" EXACT [] synonym: "up-regulation of phosphorylation" EXACT [] synonym: "upregulation of phosphorylation" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016310 ! phosphorylation relationship: positively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:32988 ! amide relationship: has_primary_input CHEBI:32988 ! amide [Term] id: GO:0043043 name: peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl] synonym: "peptide anabolism" EXACT [] synonym: "peptide biosynthesis" EXACT [] synonym: "peptide formation" EXACT [] synonym: "peptide synthesis" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:16670 ! peptide relationship: has_primary_output CHEBI:16670 ! peptide [Term] id: GO:0043062 name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: prokaryote_subset synonym: "extracellular structure organisation" EXACT [] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005576 ! extracellular region relationship: results_in_organization_of GO:0005576 ! extracellular region [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process alt_id: GO:0048554 def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: goslim_chembl subset: term_scheduled_for_obsoletion synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003824 ! catalytic activity relationship: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process alt_id: GO:0048553 def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: term_scheduled_for_obsoletion synonym: "down regulation of enzyme activity" EXACT [] synonym: "down regulation of metalloenzyme activity" NARROW [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "down-regulation of metalloenzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "downregulation of metalloenzyme activity" NARROW [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "inhibition of metalloenzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] synonym: "negative regulation of metalloenzyme activity" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003824 ! catalytic activity relationship: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043143 name: regulation of translation by machinery localization namespace: biological_process def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] synonym: "establishment and maintenance of translational machinery localization" EXACT [] synonym: "establishment and maintenance of translational protein localization" EXACT [] synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah] synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb] synonym: "translational protein localization" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0006412 ! translation relationship: part_of GO:0006412 ! translation [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 alt_id: GO:0043283 alt_id: GO:0044259 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] synonym: "multicellular organismal macromolecule metabolic process" NARROW [] synonym: "organismal macromolecule metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:33694 ! biomacromolecule relationship: has_primary_input_or_output CHEBI:33694 ! biomacromolecule property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0043171 name: peptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] synonym: "peptide breakdown" EXACT [] synonym: "peptide catabolism" EXACT [] synonym: "peptide degradation" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:16670 ! peptide relationship: has_primary_input CHEBI:16670 ! peptide [Term] id: GO:0043207 name: response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: prokaryote_subset xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: has_part GO:0016020 ! membrane relationship: has_part GO:0016020 ! membrane [Term] id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_mouse synonym: "biological condensate" RELATED [] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21881" xsd:anyURI [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005622 ! intracellular anatomical structure disjoint_from: GO:0043230 ! extracellular organelle relationship: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0043230 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005576 ! extracellular region relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_pir synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0005622 ! intracellular anatomical structure [Term] id: GO:0043242 name: negative regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "down regulation of protein complex disassembly" EXACT [] synonym: "down-regulation of protein complex disassembly" EXACT [] synonym: "downregulation of protein complex disassembly" EXACT [] synonym: "inhibition of protein complex disassembly" NARROW [] synonym: "negative regulation of protein complex disassembly" RELATED [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032984 ! protein-containing complex disassembly relationship: negatively_regulates GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0043243 name: positive regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "activation of protein complex disassembly" NARROW [] synonym: "positive regulation of protein complex disassembly" RELATED [] synonym: "stimulation of protein complex disassembly" NARROW [] synonym: "up regulation of protein complex disassembly" EXACT [] synonym: "up-regulation of protein complex disassembly" EXACT [] synonym: "upregulation of protein complex disassembly" EXACT [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032984 ! protein-containing complex disassembly relationship: positively_regulates GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0043244 name: regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "regulation of protein complex disassembly" RELATED [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032984 ! protein-containing complex disassembly relationship: regulates GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0043254 name: regulation of protein-containing complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] synonym: "regulation of protein complex assembly" RELATED [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0065003 ! protein-containing complex assembly relationship: regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0043385 name: mycotoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] synonym: "mycotoxin metabolism" EXACT [] is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0043386 name: mycotoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] synonym: "mycotoxin anabolism" EXACT [] synonym: "mycotoxin biosynthesis" EXACT [] synonym: "mycotoxin formation" EXACT [] synonym: "mycotoxin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0043385 ! mycotoxin metabolic process [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: goslim_pir is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:35406 ! oxoanion relationship: has_primary_input_or_output CHEBI:35406 ! oxoanion [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0043476 name: pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl] synonym: "pigment accumulation in response to external stimulus" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0043473 ! pigmentation [Term] id: GO:0043482 name: cellular pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl] is_a: GO:0033059 ! cellular pigmentation is_a: GO:0043476 ! pigment accumulation is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0043549 name: regulation of kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] subset: term_scheduled_for_obsoletion is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016301 ! kinase activity relationship: regulates GO:0016301 ! kinase activity [Term] id: GO:0043603 name: amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] subset: goslim_pir synonym: "amide metabolism" EXACT [] synonym: "cellular amide metabolic process" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:32988 ! amide relationship: has_primary_input_or_output CHEBI:32988 ! amide [Term] id: GO:0043604 name: amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] is_a: GO:0043603 ! amide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:32988 ! amide relationship: has_primary_output CHEBI:32988 ! amide [Term] id: GO:0043605 name: amide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] synonym: "cellular amide catabolic process" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_output CHEBI:32988 ! amide relationship: has_primary_output CHEBI:32988 ! amide [Term] id: GO:0043933 name: protein-containing complex organization namespace: biological_process alt_id: GO:0034600 alt_id: GO:0034621 alt_id: GO:0071822 def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] synonym: "cellular macromolecular complex organization" RELATED [] synonym: "cellular macromolecular complex subunit organisation" RELATED [] synonym: "cellular macromolecular complex subunit organization" RELATED [] synonym: "macromolecular complex organization" RELATED [] synonym: "macromolecular complex subunit organisation" RELATED [] synonym: "macromolecular complex subunit organization" RELATED [] synonym: "protein complex subunit organisation" EXACT [GOC:mah] synonym: "protein complex subunit organization" EXACT [] synonym: "protein-containing complex subunit organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0032991 ! protein-containing complex relationship: results_in_organization_of GO:0032991 ! protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI created_by: mah creation_date: 2010-09-08T10:01:42Z [Term] id: GO:0043934 name: sporulation namespace: biological_process def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] subset: goslim_metagenomics subset: goslim_yeast xref: Wikipedia:Spore is_a: GO:0032502 ! developmental process [Term] id: GO:0043935 name: sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0034293 ! sexual sporulation intersection_of: GO:0030435 ! sporulation resulting in formation of a cellular spore intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0043936 name: asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] synonym: "asexual reproduction resulting in the formation of a cellular spore" EXACT [GOC:di] synonym: "asexual sporulation resulting in the formation of a viable spore" BROAD [GOC:di] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0030436 ! asexual sporulation [Term] id: GO:0044001 name: migration in host namespace: biological_process def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "migration within host" EXACT [] is_a: GO:0051701 ! biological process involved in interaction with host [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044085 ! cellular component biogenesis relationship: regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044088 name: regulation of vacuole organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007033 ! vacuole organization relationship: regulates GO:0007033 ! vacuole organization [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044085 ! cellular component biogenesis relationship: positively_regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044090 name: positive regulation of vacuole organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007033 ! vacuole organization relationship: positively_regulates GO:0007033 ! vacuole organization [Term] id: GO:0044091 name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: has_output GO:0016020 ! membrane relationship: has_output GO:0016020 ! membrane [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: term_scheduled_for_obsoletion is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003674 ! molecular_function relationship: negatively_regulates GO:0003674 ! molecular_function created_by: jl creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: term_scheduled_for_obsoletion is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003674 ! molecular_function relationship: positively_regulates GO:0003674 ! molecular_function created_by: jl creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044111 name: formation of structure involved in a symbiotic process namespace: biological_process alt_id: GO:0044115 alt_id: GO:0044152 def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] synonym: "development during symbiotic interaction" RELATED [GOC:dph] synonym: "development involved in symbiotic interaction" RELATED [] synonym: "development of symbiont during interaction with host" RELATED [GOC:dph] synonym: "development of symbiont involved in interaction with host" RELATED [] synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "development on or near surface of other organism involved in symbiotic interaction" NARROW [] is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20305" xsd:anyURI created_by: jl creation_date: 2009-07-30T02:26:46Z [Term] id: GO:0044114 name: development of symbiont in host namespace: biological_process alt_id: GO:0044122 alt_id: GO:0044124 def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'biological process involved in interaction with host ; GO:0051701. synonym: "development of symbiont in host intercellular space" NARROW [] synonym: "development of symbiont in host vascular tissue" NARROW [] is_a: GO:0044111 ! formation of structure involved in a symbiotic process created_by: jl creation_date: 2009-07-30T03:39:25Z [Term] id: GO:0044207 name: translation initiation ternary complex namespace: cellular_component def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl] synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW [] synonym: "translation initiation (ternary) complex" EXACT [] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005737 ! cytoplasm created_by: jl creation_date: 2009-10-22T02:38:55Z [Term] id: GO:0044237 name: cellular metabolic process namespace: biological_process def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0044248 name: cellular catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl] synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044249 name: cellular biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] synonym: "cellular anabolism" EXACT [] synonym: "cellular biosynthesis" EXACT [] synonym: "cellular formation" EXACT [] synonym: "cellular synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044255 name: cellular lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] subset: goslim_pir synonym: "cellular lipid metabolism" EXACT [] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044270 name: cellular nitrogen compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] synonym: "nitrogen compound breakdown" BROAD [] synonym: "nitrogen compound catabolism" BROAD [] synonym: "nitrogen compound degradation" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] synonym: "nitrogen compound anabolism" BROAD [] synonym: "nitrogen compound biosynthesis" BROAD [] synonym: "nitrogen compound formation" BROAD [] synonym: "nitrogen compound synthesis" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044282 name: small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044281 ! small molecule metabolic process created_by: jl creation_date: 2010-01-26T12:06:10Z [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_prokaryote subset: prokaryote_subset synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process created_by: jl creation_date: 2010-01-26T12:06:49Z [Term] id: GO:0044403 name: biological process involved in symbiotic interaction name: symbiosis, encompassing mutualism through parasitism namespace: biological_process alt_id: GO:0043298 alt_id: GO:0044404 alt_id: GO:0072519 alt_id: GO:0085031 def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, PMID:31257129] def: "An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs." [] subset: goslim_chembl synonym: "commensalism" NARROW [] synonym: "host-pathogen interaction" NARROW [] synonym: "parasitism" NARROW [] synonym: "symbiosis" RELATED [] synonym: "symbiosis, encompassing mutualism through parasitism" RELATED [] synonym: "symbiotic interaction" RELATED [] synonym: "symbiotic interaction between host and organism" RELATED [] synonym: "symbiotic interaction between organisms" RELATED [] synonym: "symbiotic interaction between species" RELATED [] synonym: "symbiotic process" RELATED [] is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms is_a: GO:0051704 ! multi-organism process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14807" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044409 name: entry into host name: symbiont entry into host namespace: biological_process alt_id: GO:0030260 alt_id: GO:0044411 alt_id: GO:0051806 alt_id: GO:0051828 alt_id: GO:0051830 alt_id: GO:0075052 alt_id: GO:0085027 alt_id: GO:0085028 def: "Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:vw] def: "Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [] synonym: "entry into cell of other organism during symbiotic interaction" NARROW [GOC:tb] synonym: "entry into cell of other organism involved in symbiotic interaction" RELATED [] synonym: "entry into host" EXACT [] synonym: "entry into host cell via penetration peg" NARROW [] synonym: "entry into host through host barriers" RELATED [] synonym: "entry into host via a specialized structure during symbiotic interaction" NARROW [] synonym: "entry into host via enzymatic degradation of host anatomical structure" NARROW [] synonym: "entry into host via enzymatic degradation of host cuticle" NARROW [] synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "entry into other organism involved in symbiotic interaction" RELATED [] synonym: "host invasion" EXACT [] synonym: "host penetration" EXACT [GOC:vw] synonym: "invasion into host" EXACT [] synonym: "invasion into other organism" RELATED [] synonym: "invasion of host" EXACT [] synonym: "invasion of other organism" RELATED [] synonym: "invasive growth" RELATED [] synonym: "other organism invasion" RELATED [] synonym: "penetration into host" EXACT [GOC:vw] synonym: "penetration into host via a specialized structure" NARROW [GOC:vw] synonym: "penetration into host via a specialized structure during symbiotic interaction" NARROW [GOC:vw] is_a: GO:0051701 ! biological process involved in interaction with host property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18563" xsd:anyURI property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044419 name: biological process involved in interspecies interaction between organisms namespace: biological_process def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction between organisms" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] is_a: GO:0008150 ! biological_process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0044464 name: obsolete cell part namespace: cellular_component def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602] synonym: "protoplast" RELATED [GOC:mah] is_obsolete: true [Term] id: GO:0044550 name: secondary metabolite biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] subset: goslim_prokaryote synonym: "secondary metabolite biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0019748 ! secondary metabolic process created_by: jl creation_date: 2012-03-29T01:55:18Z [Term] id: GO:0044848 name: biological phase namespace: biological_process def: "A distinct period or stage in a biological process or cycle." [GOC:jl] comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. subset: gocheck_do_not_manually_annotate is_a: GO:0008150 ! biological_process disjoint_from: GO:0050896 ! response to stimulus disjoint_from: GO:0051179 ! localization disjoint_from: GO:0071840 ! cellular component organization or biogenesis created_by: jl creation_date: 2014-07-16T13:12:40Z [Term] id: GO:0044877 name: protein-containing complex binding namespace: molecular_function alt_id: GO:0032403 def: "Binding to a macromolecular complex." [GOC:jl] subset: goslim_chembl synonym: "macromolecular complex binding" RELATED [] synonym: "protein complex binding" EXACT [] is_a: GO:0005488 ! binding created_by: jl creation_date: 2014-12-16T11:38:58Z [Term] id: GO:0045026 name: plasma membrane fusion namespace: biological_process alt_id: GO:0006947 def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" BROAD [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0061025 ! membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fusion_of GO:0005886 ! plasma membrane relationship: results_in_fusion_of GO:0005886 ! plasma membrane [Term] id: GO:0045087 name: innate immune response namespace: biological_process alt_id: GO:0002226 def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] synonym: "innate immunity" EXACT [GOC:pg] synonym: "nonspecific immune response" EXACT [] xref: Wikipedia:Innate_immune_system is_a: GO:0006955 ! immune response is_a: GO:0140546 ! defense response to symbiont property_value: RO:0002161 NCBITaxon_Union:0000023 [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: has_primary_input CHEBI:36080 ! protein [Term] id: GO:0045229 name: external encapsulating structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "external encapsulating structure organisation" EXACT [] synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0045727 name: positive regulation of translation namespace: biological_process alt_id: GO:0045946 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of protein biosynthetic process" NARROW [] synonym: "positive regulation of protein anabolism" EXACT [] synonym: "positive regulation of protein biosynthesis" EXACT [] synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] synonym: "positive regulation of protein formation" EXACT [] synonym: "positive regulation of protein synthesis" EXACT [] synonym: "stimulation of protein biosynthetic process" NARROW [] synonym: "up regulation of protein biosynthetic process" EXACT [] synonym: "up-regulation of protein biosynthetic process" EXACT [] synonym: "upregulation of protein biosynthetic process" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of amide metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006412 ! translation relationship: positively_regulates GO:0006412 ! translation [Term] id: GO:0045730 name: respiratory burst namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732] synonym: "metabolic burst" EXACT [] synonym: "oxidative burst" EXACT [] xref: Wikipedia:Respiratory_burst is_a: GO:0008152 ! metabolic process [Term] id: GO:0045732 name: positive regulation of protein catabolic process namespace: biological_process alt_id: GO:1903364 alt_id: GO:2000600 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "activation of protein catabolic process" NARROW [] synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolic process" EXACT [] synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "positive regulation of cyclin catabolic process" NARROW [] synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol] synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "positive regulation of protein breakdown" EXACT [] synonym: "positive regulation of protein catabolism" EXACT [] synonym: "positive regulation of protein degradation" EXACT [] synonym: "stimulation of protein catabolic process" NARROW [] synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein catabolic process" EXACT [] synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein catabolic process" EXACT [] synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030163 ! protein catabolic process relationship: positively_regulates GO:0030163 ! protein catabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0045763 name: negative regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "down regulation of amino acid metabolic process" EXACT [] synonym: "down-regulation of amino acid metabolic process" EXACT [] synonym: "downregulation of amino acid metabolic process" EXACT [] synonym: "inhibition of amino acid metabolic process" NARROW [] synonym: "negative regulation of amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006520 ! amino acid metabolic process relationship: negatively_regulates GO:0006520 ! amino acid metabolic process [Term] id: GO:0045764 name: positive regulation of amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "activation of amino acid metabolic process" NARROW [] synonym: "positive regulation of amino acid metabolism" EXACT [] synonym: "positive regulation of cellular amino acid metabolic process" EXACT [] synonym: "stimulation of amino acid metabolic process" NARROW [] synonym: "up regulation of amino acid metabolic process" EXACT [] synonym: "up-regulation of amino acid metabolic process" EXACT [] synonym: "upregulation of amino acid metabolic process" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006520 ! amino acid metabolic process relationship: positively_regulates GO:0006520 ! amino acid metabolic process [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007049 ! cell cycle relationship: negatively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007049 ! cell cycle relationship: positively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045806 name: negative regulation of endocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "down regulation of endocytosis" EXACT [] synonym: "down-regulation of endocytosis" EXACT [] synonym: "downregulation of endocytosis" EXACT [] synonym: "inhibition of endocytosis" NARROW [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006897 ! endocytosis relationship: negatively_regulates GO:0006897 ! endocytosis [Term] id: GO:0045807 name: positive regulation of endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "activation of endocytosis" NARROW [] synonym: "stimulation of endocytosis" NARROW [] synonym: "up regulation of endocytosis" EXACT [] synonym: "up-regulation of endocytosis" EXACT [] synonym: "upregulation of endocytosis" EXACT [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006897 ! endocytosis relationship: positively_regulates GO:0006897 ! endocytosis [Term] id: GO:0045833 name: negative regulation of lipid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "down regulation of lipid metabolic process" EXACT [] synonym: "down-regulation of lipid metabolic process" EXACT [] synonym: "downregulation of lipid metabolic process" EXACT [] synonym: "inhibition of lipid metabolic process" NARROW [] synonym: "negative regulation of lipid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006629 ! lipid metabolic process relationship: negatively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045834 name: positive regulation of lipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "activation of lipid metabolic process" NARROW [] synonym: "positive regulation of lipid metabolism" EXACT [] synonym: "stimulation of lipid metabolic process" NARROW [] synonym: "up regulation of lipid metabolic process" EXACT [] synonym: "up-regulation of lipid metabolic process" EXACT [] synonym: "upregulation of lipid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006629 ! lipid metabolic process relationship: positively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045835 name: negative regulation of meiotic nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] synonym: "negative regulation of meiosis" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0140013 ! meiotic nuclear division relationship: negatively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045836 name: positive regulation of meiotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "positive regulation of meiosis" EXACT [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0140013 ! meiotic nuclear division relationship: positively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045900 name: negative regulation of translational elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "down regulation of translational elongation" EXACT [] synonym: "down-regulation of translational elongation" EXACT [] synonym: "downregulation of translational elongation" EXACT [] synonym: "inhibition of translational elongation" NARROW [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006414 ! translational elongation relationship: negatively_regulates GO:0006414 ! translational elongation [Term] id: GO:0045901 name: positive regulation of translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "activation of translational elongation" NARROW [] synonym: "stimulation of translational elongation" NARROW [] synonym: "up regulation of translational elongation" EXACT [] synonym: "up-regulation of translational elongation" EXACT [] synonym: "upregulation of translational elongation" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006414 ! translational elongation relationship: positively_regulates GO:0006414 ! translational elongation [Term] id: GO:0045904 name: negative regulation of translational termination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "down regulation of translational termination" EXACT [] synonym: "down-regulation of translational termination" EXACT [] synonym: "downregulation of translational termination" EXACT [] synonym: "inhibition of translational termination" NARROW [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006415 ! translational termination relationship: negatively_regulates GO:0006415 ! translational termination [Term] id: GO:0045905 name: positive regulation of translational termination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "activation of translational termination" NARROW [] synonym: "stimulation of translational termination" NARROW [] synonym: "up regulation of translational termination" EXACT [] synonym: "up-regulation of translational termination" EXACT [] synonym: "upregulation of translational termination" EXACT [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006415 ! translational termination relationship: positively_regulates GO:0006415 ! translational termination [Term] id: GO:0045920 name: negative regulation of exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "down regulation of exocytosis" EXACT [] synonym: "down-regulation of exocytosis" EXACT [] synonym: "downregulation of exocytosis" EXACT [] synonym: "inhibition of exocytosis" NARROW [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006887 ! exocytosis relationship: negatively_regulates GO:0006887 ! exocytosis [Term] id: GO:0045921 name: positive regulation of exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "activation of exocytosis" NARROW [] synonym: "stimulation of exocytosis" NARROW [] synonym: "up regulation of exocytosis" EXACT [] synonym: "up-regulation of exocytosis" EXACT [] synonym: "upregulation of exocytosis" EXACT [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006887 ! exocytosis relationship: positively_regulates GO:0006887 ! exocytosis [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045936 name: negative regulation of phosphate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "down regulation of phosphate metabolic process" EXACT [] synonym: "down-regulation of phosphate metabolic process" EXACT [] synonym: "downregulation of phosphate metabolic process" EXACT [] synonym: "inhibition of phosphate metabolic process" NARROW [] synonym: "negative regulation of phosphate metabolism" EXACT [] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045937 name: positive regulation of phosphate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "activation of phosphate metabolic process" NARROW [] synonym: "positive regulation of phosphate metabolism" EXACT [] synonym: "stimulation of phosphate metabolic process" NARROW [] synonym: "up regulation of phosphate metabolic process" EXACT [] synonym: "up-regulation of phosphate metabolic process" EXACT [] synonym: "upregulation of phosphate metabolic process" EXACT [] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045947 name: negative regulation of translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "down regulation of translational initiation" EXACT [] synonym: "down-regulation of translational initiation" EXACT [] synonym: "downregulation of translational initiation" EXACT [] synonym: "inhibition of translational initiation" NARROW [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006413 ! translational initiation relationship: negatively_regulates GO:0006413 ! translational initiation [Term] id: GO:0045948 name: positive regulation of translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "activation of translational initiation" NARROW [] synonym: "stimulation of translational initiation" NARROW [] synonym: "up regulation of translational initiation" EXACT [] synonym: "up-regulation of translational initiation" EXACT [] synonym: "upregulation of translational initiation" EXACT [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006413 ! translational initiation relationship: positively_regulates GO:0006413 ! translational initiation [Term] id: GO:0046112 name: nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] synonym: "nucleobase anabolism" EXACT [] synonym: "nucleobase biosynthesis" EXACT [] synonym: "nucleobase formation" EXACT [] synonym: "nucleobase synthesis" EXACT [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:18282 ! nucleobase relationship: has_primary_output CHEBI:18282 ! nucleobase [Term] id: GO:0046113 name: nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] synonym: "nucleobase breakdown" EXACT [] synonym: "nucleobase catabolism" EXACT [] synonym: "nucleobase degradation" EXACT [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:18282 ! nucleobase relationship: has_primary_input CHEBI:18282 ! nucleobase [Term] id: GO:0046165 name: alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] synonym: "alcohol anabolism" EXACT [] synonym: "alcohol biosynthesis" EXACT [] synonym: "alcohol formation" EXACT [] synonym: "alcohol synthesis" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0046173 name: polyol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators] synonym: "polyhydric alcohol biosynthetic process" EXACT [] synonym: "polyol anabolism" EXACT [] synonym: "polyol biosynthesis" EXACT [] synonym: "polyol formation" EXACT [] synonym: "polyol synthesis" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0046394 name: carboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid anabolism" EXACT [] synonym: "carboxylic acid biosynthesis" EXACT [] synonym: "carboxylic acid formation" EXACT [] synonym: "carboxylic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:29067 ! carboxylic acid anion relationship: has_primary_output CHEBI:29067 ! carboxylic acid anion [Term] id: GO:0046395 name: carboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid breakdown" EXACT [] synonym: "carboxylic acid catabolism" EXACT [] synonym: "carboxylic acid degradation" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion relationship: has_primary_input CHEBI:29067 ! carboxylic acid anion [Term] id: GO:0046483 name: heterocycle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732] subset: goslim_pir synonym: "heterocycle metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:5686 ! heterocyclic compound relationship: has_primary_input_or_output CHEBI:5686 ! heterocyclic compound [Term] id: GO:0046700 name: heterocycle catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai] synonym: "heterocycle breakdown" EXACT [] synonym: "heterocycle catabolism" EXACT [] synonym: "heterocycle degradation" EXACT [] is_a: GO:0044248 ! cellular catabolic process is_a: GO:0046483 ! heterocycle metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:5686 ! heterocyclic compound relationship: has_primary_input CHEBI:5686 ! heterocyclic compound [Term] id: GO:0046889 name: positive regulation of lipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "activation of lipid biosynthetic process" NARROW [] synonym: "positive regulation of lipid anabolism" EXACT [] synonym: "positive regulation of lipid biosynthesis" EXACT [] synonym: "positive regulation of lipid formation" EXACT [] synonym: "positive regulation of lipid synthesis" EXACT [] synonym: "positive regulation of lipogenesis" EXACT [GOC:sl] synonym: "stimulation of lipid biosynthetic process" NARROW [] synonym: "up regulation of lipid biosynthetic process" EXACT [] synonym: "up-regulation of lipid biosynthetic process" EXACT [] synonym: "upregulation of lipid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008610 ! lipid biosynthetic process relationship: positively_regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0046890 name: regulation of lipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "regulation of lipid anabolism" EXACT [] synonym: "regulation of lipid biosynthesis" EXACT [] synonym: "regulation of lipid formation" EXACT [] synonym: "regulation of lipid synthesis" EXACT [] synonym: "regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008610 ! lipid biosynthetic process relationship: regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0046907 name: intracellular transport namespace: biological_process alt_id: GO:1902582 def: "The directed movement of substances within a cell." [GOC:ai] synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intracellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0051641 ! cellular localization is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure relationship: occurs_in GO:0005622 ! intracellular anatomical structure created_by: jl creation_date: 2013-12-18T14:04:50Z [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] is_a: GO:0015711 ! organic anion transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion relationship: has_primary_input CHEBI:29067 ! carboxylic acid anion [Term] id: GO:0048029 name: monosaccharide binding namespace: molecular_function def: "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] is_a: GO:0030246 ! carbohydrate binding is_a: GO:0036094 ! small molecule binding [Term] id: GO:0048102 name: autophagic cell death namespace: biological_process def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517] comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not. synonym: "autophagic death" BROAD [] synonym: "autosis" RELATED [PMID:25236395] synonym: "programmed cell death by autophagy" BROAD [GOC:pr] synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm] synonym: "type II programmed cell death" RELATED [GOC:sl] is_a: GO:0012501 ! programmed cell death intersection_of: GO:0012501 ! programmed cell death intersection_of: has_part GO:0016236 ! macroautophagy relationship: has_part GO:0016236 ! macroautophagy [Term] id: GO:0048284 name: organelle fusion namespace: biological_process def: "The creation of a single organelle from two or more organelles." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fusion_of GO:0043226 ! organelle relationship: results_in_fusion_of GO:0043226 ! organelle [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fission_of GO:0043226 ! organelle relationship: results_in_fission_of GO:0043226 ! organelle [Term] id: GO:0048288 name: nuclear membrane fusion involved in karyogamy namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid] synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0000740 ! nuclear membrane fusion intersection_of: GO:0000740 ! nuclear membrane fusion intersection_of: part_of GO:0000741 ! karyogamy relationship: part_of GO:0000741 ! karyogamy [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process alt_id: GO:0043119 def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008150 ! biological_process relationship: positively_regulates GO:0008150 ! biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process alt_id: GO:0043118 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008150 ! biological_process relationship: negatively_regulates GO:0008150 ! biological_process [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process alt_id: GO:0051242 def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009987 ! cellular process relationship: positively_regulates GO:0009987 ! cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process alt_id: GO:0051243 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009987 ! cellular process relationship: negatively_regulates GO:0009987 ! cellular process [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0040007 ! growth intersection_of: GO:0040007 ! growth intersection_of: part_of GO:0032502 ! developmental process relationship: part_of GO:0032502 ! developmental process [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0050657 name: nucleic acid transport namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] is_a: GO:0015931 ! nucleobase-containing compound transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:33696 ! nucleic acid relationship: has_primary_input CHEBI:33696 ! nucleic acid [Term] id: GO:0050658 name: RNA transport namespace: biological_process def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid relationship: has_primary_input CHEBI:33697 ! ribonucleic acid [Term] id: GO:0050708 name: regulation of protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009306 ! protein secretion relationship: regulates GO:0009306 ! protein secretion [Term] id: GO:0050709 name: negative regulation of protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "down regulation of protein secretion" EXACT [] synonym: "down-regulation of protein secretion" EXACT [] synonym: "downregulation of protein secretion" EXACT [] synonym: "inhibition of protein secretion" NARROW [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009306 ! protein secretion relationship: negatively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050714 name: positive regulation of protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "activation of protein secretion" NARROW [] synonym: "stimulation of protein secretion" NARROW [] synonym: "up regulation of protein secretion" EXACT [] synonym: "up-regulation of protein secretion" EXACT [] synonym: "upregulation of protein secretion" EXACT [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009306 ! protein secretion relationship: positively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process alt_id: GO:0048552 def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: goslim_chembl subset: term_scheduled_for_obsoletion synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003824 ! catalytic activity relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009987 ! cellular process relationship: regulates GO:0009987 ! cellular process [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050994 name: regulation of lipid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "regulation of lipid breakdown" EXACT [] synonym: "regulation of lipid catabolism" EXACT [] synonym: "regulation of lipid degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016042 ! lipid catabolic process relationship: regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050995 name: negative regulation of lipid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "down regulation of lipid catabolic process" EXACT [] synonym: "down-regulation of lipid catabolic process" EXACT [] synonym: "downregulation of lipid catabolic process" EXACT [] synonym: "inhibition of lipid catabolic process" NARROW [] synonym: "negative regulation of lipid breakdown" EXACT [] synonym: "negative regulation of lipid catabolism" EXACT [] synonym: "negative regulation of lipid degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016042 ! lipid catabolic process relationship: negatively_regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050996 name: positive regulation of lipid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "activation of lipid catabolic process" NARROW [] synonym: "positive regulation of lipid breakdown" EXACT [] synonym: "positive regulation of lipid catabolism" EXACT [] synonym: "positive regulation of lipid degradation" EXACT [] synonym: "stimulation of lipid catabolic process" NARROW [] synonym: "up regulation of lipid catabolic process" EXACT [] synonym: "up-regulation of lipid catabolic process" EXACT [] synonym: "upregulation of lipid catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016042 ! lipid catabolic process relationship: positively_regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0051046 name: regulation of secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0046903 ! secretion relationship: regulates GO:0046903 ! secretion [Term] id: GO:0051047 name: positive regulation of secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "activation of secretion" NARROW [] synonym: "stimulation of secretion" NARROW [] synonym: "up regulation of secretion" EXACT [] synonym: "up-regulation of secretion" EXACT [] synonym: "upregulation of secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0046903 ! secretion relationship: positively_regulates GO:0046903 ! secretion [Term] id: GO:0051048 name: negative regulation of secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "down regulation of secretion" EXACT [] synonym: "down-regulation of secretion" EXACT [] synonym: "downregulation of secretion" EXACT [] synonym: "inhibition of secretion" NARROW [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0046903 ! secretion relationship: negatively_regulates GO:0046903 ! secretion [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_yeast is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006810 ! transport relationship: regulates GO:0006810 ! transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006810 ! transport relationship: positively_regulates GO:0006810 ! transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006810 ! transport relationship: negatively_regulates GO:0006810 ! transport [Term] id: GO:0051055 name: negative regulation of lipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "down regulation of lipid biosynthetic process" EXACT [] synonym: "down-regulation of lipid biosynthetic process" EXACT [] synonym: "downregulation of lipid biosynthetic process" EXACT [] synonym: "inhibition of lipid biosynthetic process" NARROW [] synonym: "negative regulation of lipid anabolism" EXACT [] synonym: "negative regulation of lipid biosynthesis" EXACT [] synonym: "negative regulation of lipid formation" EXACT [] synonym: "negative regulation of lipid synthesis" EXACT [] synonym: "negative regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008610 ! lipid biosynthetic process relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0051078 name: meiotic nuclear membrane disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf] synonym: "meiotic nuclear envelope breakdown" RELATED [] synonym: "meiotic nuclear envelope catabolism" RELATED [] synonym: "meiotic nuclear envelope degradation" RELATED [] synonym: "meiotic nuclear envelope disassembly" RELATED [] is_a: GO:0051081 ! nuclear membrane disassembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051081 name: nuclear membrane disassembly namespace: biological_process def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai] synonym: "nuclear envelope breakdown" RELATED [] synonym: "nuclear envelope catabolism" RELATED [] synonym: "nuclear envelope degradation" RELATED [] synonym: "nuclear envelope disassembly" RELATED [] is_a: GO:0030397 ! membrane disassembly is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:0031965 ! nuclear membrane relationship: results_in_disassembly_of GO:0031965 ! nuclear membrane [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016043 ! cellular component organization relationship: regulates GO:0016043 ! cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016043 ! cellular component organization relationship: negatively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016043 ! cellular component organization relationship: positively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051169 name: nuclear transport namespace: biological_process def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] subset: goslim_yeast synonym: "nucleus transport" EXACT [] xref: Wikipedia:Nuclear_transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure intersection_of: results_in_transport_to_from_or_in GO:0005634 ! nucleus relationship: results_in_transport_to_from_or_in GO:0005634 ! nucleus [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "regulation of nitrogen metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006807 ! nitrogen compound metabolic process relationship: regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051172 name: negative regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "down regulation of nitrogen metabolic process" EXACT [] synonym: "down-regulation of nitrogen metabolic process" EXACT [] synonym: "downregulation of nitrogen metabolic process" EXACT [] synonym: "inhibition of nitrogen metabolic process" NARROW [] synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "negative regulation of nitrogen metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "activation of nitrogen metabolic process" NARROW [] synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "positive regulation of nitrogen metabolism" EXACT [] synonym: "stimulation of nitrogen metabolic process" NARROW [] synonym: "up regulation of nitrogen metabolic process" EXACT [] synonym: "up-regulation of nitrogen metabolic process" EXACT [] synonym: "upregulation of nitrogen metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006793 ! phosphorus metabolic process relationship: regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0051179 name: localization namespace: biological_process alt_id: GO:1902578 def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] subset: goslim_pir synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] synonym: "single organism localization" RELATED [GOC:TermGenie] synonym: "single-organism localization" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2013-12-18T13:51:04Z [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0015031 ! protein transport relationship: positively_regulates GO:0015031 ! protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015031 ! protein transport relationship: regulates GO:0015031 ! protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0015031 ! protein transport relationship: negatively_regulates GO:0015031 ! protein transport [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI [Term] id: GO:0051236 name: establishment of RNA localization namespace: biological_process def: "The directed movement of RNA to a specific location." [GOC:ai] synonym: "establishment of RNA localisation" EXACT [GOC:mah] synonym: "RNA positioning" EXACT [] synonym: "RNA recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0006403 ! RNA localization [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process alt_id: GO:0032268 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "regulation of cellular protein metabolic process" RELATED [] synonym: "regulation of cellular protein metabolism" RELATED [] synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019538 ! protein metabolic process relationship: regulates GO:0019538 ! protein metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process alt_id: GO:0032270 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolic process" EXACT [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019538 ! protein metabolic process relationship: positively_regulates GO:0019538 ! protein metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process alt_id: GO:0032269 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolic process" EXACT [] synonym: "negative regulation of cellular protein metabolism" EXACT [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019538 ! protein metabolic process relationship: negatively_regulates GO:0019538 ! protein metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016070 ! RNA metabolic process relationship: regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016070 ! RNA metabolic process relationship: negatively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016070 ! RNA metabolic process relationship: positively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process alt_id: GO:0007126 def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_drosophila subset: goslim_yeast synonym: "meiosis" RELATED [] xref: Wikipedia:Meiosis is_a: GO:0007049 ! cell cycle is_a: GO:0022414 ! reproductive process intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140013 ! meiotic nuclear division relationship: has_part GO:0140013 ! meiotic nuclear division relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota relationship: part_of GO:0019953 ! sexual reproduction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24599" xsd:anyURI [Term] id: GO:0051326 name: telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Telophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051327 name: meiotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of meiotic cell cycle" EXACT [] is_a: GO:0000279 ! M phase is_a: GO:0098762 ! meiotic cell cycle phase intersection_of: GO:0000279 ! M phase intersection_of: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate subset: term_scheduled_for_obsoletion synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016740 ! transferase activity relationship: regulates GO:0016740 ! transferase activity [Term] id: GO:0051347 name: positive regulation of transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate subset: term_scheduled_for_obsoletion synonym: "activation of transferase activity" NARROW [] synonym: "stimulation of transferase activity" NARROW [] synonym: "transferase activator" EXACT [] synonym: "up regulation of transferase activity" EXACT [] synonym: "up-regulation of transferase activity" EXACT [] synonym: "upregulation of transferase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016740 ! transferase activity relationship: positively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051348 name: negative regulation of transferase activity namespace: biological_process def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate subset: term_scheduled_for_obsoletion synonym: "down regulation of transferase activity" EXACT [] synonym: "down-regulation of transferase activity" EXACT [] synonym: "downregulation of transferase activity" EXACT [] synonym: "inhibition of transferase activity" NARROW [] synonym: "transferase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016740 ! transferase activity relationship: negatively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051321 ! meiotic cell cycle relationship: regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051321 ! meiotic cell cycle relationship: positively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051321 ! meiotic cell cycle relationship: negatively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051469 name: vesicle fusion with vacuole namespace: biological_process alt_id: GO:0042146 def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] is_a: GO:0006906 ! vesicle fusion is_a: GO:0097576 ! vacuole fusion intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fusion_of GO:0005773 ! vacuole intersection_of: results_in_fusion_of GO:0031982 ! vesicle relationship: results_in_fusion_of GO:0031982 ! vesicle [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: has_primary_input GO:0043226 ! organelle relationship: has_primary_input GO:0043226 ! organelle relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI [Term] id: GO:0051641 name: cellular localization namespace: biological_process alt_id: GO:1902580 def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] subset: goslim_pir synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] synonym: "single-organism cellular localization" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization created_by: jl creation_date: 2013-12-18T14:04:32Z [Term] id: GO:0051647 name: nucleus localization namespace: biological_process def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "cell nucleus localization" EXACT [] synonym: "establishment and maintenance of nucleus localization" EXACT [] synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: has_primary_input GO:0005634 ! nucleus relationship: has_primary_input GO:0005634 ! nucleus [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: has_primary_input GO:0031982 ! vesicle relationship: has_primary_input GO:0031982 ! vesicle [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: occurs_in CL:0000000 ! cell relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms relationship: occurs_in CL:0000000 ! cell relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: has_primary_input GO:0031982 ! vesicle [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: has_primary_input GO:0043226 ! organelle [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: has_target_end_location GO:0016020 ! membrane relationship: has_target_end_location GO:0016020 ! membrane [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: has_primary_input CL:0000000 ! cell relationship: has_primary_input CL:0000000 ! cell [Term] id: GO:0051701 name: biological process involved in interaction with host namespace: biological_process alt_id: GO:0044112 alt_id: GO:0044116 alt_id: GO:0044117 alt_id: GO:0044119 alt_id: GO:0044121 alt_id: GO:0044123 alt_id: GO:0044125 def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] synonym: "growth of symbiont in host" NARROW [] synonym: "growth of symbiont in host cell" NARROW [] synonym: "growth of symbiont in host organelle" NARROW [] synonym: "growth of symbiont in host vacuole" NARROW [] synonym: "interaction with host" EXACT [] is_a: GO:0044403 ! biological process involved in symbiotic interaction property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI [Term] id: GO:0051704 name: multi-organism process def: "A biological process which involves another organism of the same or different species." [] is_a: GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051707 name: response to other organism namespace: biological_process alt_id: GO:0009613 alt_id: GO:0042828 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 alt_id: GO:0007050 alt_id: GO:0071156 alt_id: GO:0071157 alt_id: GO:0071158 alt_id: GO:0071850 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah] synonym: "cell cycle arrest" NARROW [] synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "mitotic cell cycle arrest" NARROW [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "negative regulation of cell cycle arrest" NARROW [] synonym: "positive regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007049 ! cell cycle relationship: regulates GO:0007049 ! cell cycle [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000280 ! nuclear division relationship: regulates GO:0000280 ! nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000280 ! nuclear division relationship: negatively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000280 ! nuclear division relationship: positively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051952 name: regulation of amine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015837 ! amine transport relationship: regulates GO:0015837 ! amine transport [Term] id: GO:0051953 name: negative regulation of amine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amine transport" EXACT [] synonym: "down-regulation of amine transport" EXACT [] synonym: "downregulation of amine transport" EXACT [] synonym: "inhibition of amine transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0015837 ! amine transport relationship: negatively_regulates GO:0015837 ! amine transport [Term] id: GO:0051954 name: positive regulation of amine transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amine transport" NARROW [] synonym: "stimulation of amine transport" NARROW [] synonym: "up regulation of amine transport" EXACT [] synonym: "up-regulation of amine transport" EXACT [] synonym: "upregulation of amine transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0015837 ! amine transport relationship: positively_regulates GO:0015837 ! amine transport [Term] id: GO:0051955 name: regulation of amino acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006865 ! amino acid transport relationship: regulates GO:0006865 ! amino acid transport [Term] id: GO:0051956 name: negative regulation of amino acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amino acid transport" EXACT [] synonym: "down-regulation of amino acid transport" EXACT [] synonym: "downregulation of amino acid transport" EXACT [] synonym: "inhibition of amino acid transport" NARROW [] synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006865 ! amino acid transport relationship: negatively_regulates GO:0006865 ! amino acid transport [Term] id: GO:0051957 name: positive regulation of amino acid transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amino acid transport" NARROW [] synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah] synonym: "stimulation of amino acid transport" NARROW [] synonym: "up regulation of amino acid transport" EXACT [] synonym: "up-regulation of amino acid transport" EXACT [] synonym: "upregulation of amino acid transport" EXACT [] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006865 ! amino acid transport relationship: positively_regulates GO:0006865 ! amino acid transport [Term] id: GO:0055086 name: nucleobase-containing small molecule metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_yeast subset: prokaryote_subset synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043170 ! macromolecule metabolic process relationship: regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051641 ! cellular localization relationship: regulates GO:0051641 ! cellular localization [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016192 ! vesicle-mediated transport relationship: regulates GO:0016192 ! vesicle-mediated transport created_by: dph creation_date: 2009-05-18T02:29:43Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: prokaryote_subset synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0016020 ! membrane relationship: results_in_organization_of GO:0016020 ! membrane created_by: jl creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061025 name: membrane fusion namespace: biological_process alt_id: GO:0006944 alt_id: GO:0044801 def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cellular membrane fusion" EXACT [] synonym: "single-organism membrane fusion" RELATED [] xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: results_in_fusion_of GO:0016020 ! membrane relationship: results_in_fusion_of GO:0016020 ! membrane created_by: jl creation_date: 2010-02-08T02:48:06Z [Term] id: GO:0061650 name: ubiquitin-like protein conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" BROAD [] synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:15:27Z [Term] id: GO:0061651 name: Atg12 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" BROAD [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:17:36Z [Term] id: GO:0061659 name: ubiquitin-like protein ligase activity namespace: molecular_function def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] synonym: "small conjugating protein ligase activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:46:23Z [Term] id: GO:0061660 name: Atg12 ligase activity namespace: molecular_function def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" BROAD [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T13:50:42Z [Term] id: GO:0061695 name: transferase complex, transferring phosphorus-containing groups namespace: cellular_component def: "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] is_a: GO:1990234 ! transferase complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: capable_of GO:0016772 ! transferase activity, transferring phosphorus-containing groups relationship: capable_of GO:0016772 ! transferase activity, transferring phosphorus-containing groups created_by: dph creation_date: 2015-05-06T11:22:38Z [Term] id: GO:0061736 name: engulfment of target by autophagosome namespace: biological_process def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL] is_a: GO:0010324 ! membrane invagination intersection_of: GO:0010324 ! membrane invagination intersection_of: part_of GO:0000045 ! autophagosome assembly relationship: part_of GO:0000045 ! autophagosome assembly created_by: dph creation_date: 2015-09-14T14:10:24Z [Term] id: GO:0061919 name: process utilizing autophagic mechanism namespace: biological_process def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process created_by: dph creation_date: 2017-07-13T19:42:14Z [Term] id: GO:0061951 name: establishment of protein localization to plasma membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw] is_a: GO:0072659 ! protein localization to plasma membrane is_a: GO:0090150 ! establishment of protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: has_target_end_location GO:0005886 ! plasma membrane intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure created_by: dph creation_date: 2017-10-26T12:55:15Z [Term] id: GO:0061982 name: meiosis I cell cycle process namespace: biological_process def: "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397] synonym: "first meiotic cell division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process created_by: dph creation_date: 2018-02-14T22:27:20Z [Term] id: GO:0061983 name: meiosis II cell cycle process namespace: biological_process def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397] synonym: "second meiotic division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process created_by: dph creation_date: 2018-02-14T22:37:44Z [Term] id: GO:0062012 name: regulation of small molecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] synonym: "regulation of small molecule metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044281 ! small molecule metabolic process relationship: regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:11:54Z [Term] id: GO:0062013 name: positive regulation of small molecule metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "positive regulation of small molecule metabolism" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044281 ! small molecule metabolic process relationship: positively_regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:25:10Z [Term] id: GO:0062014 name: negative regulation of small molecule metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "negative regulation of small molecule metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044281 ! small molecule metabolic process relationship: negatively_regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:27:23Z [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 alt_id: GO:0034622 alt_id: GO:0043623 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: prokaryote_subset synonym: "cellular macromolecule complex assembly" RELATED [] synonym: "cellular protein complex assembly" EXACT [] synonym: "cellular protein-containing complex assembly" RELATED [] synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0032991 ! protein-containing complex relationship: results_in_assembly_of GO:0032991 ! protein-containing complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant subset: term_scheduled_for_obsoletion synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003674 ! molecular_function relationship: regulates GO:0003674 ! molecular_function [Term] id: GO:0065010 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: part_of GO:0005576 ! extracellular region [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045184 ! establishment of protein localization relationship: regulates GO:0045184 ! establishment of protein localization [Term] id: GO:0070265 name: obsolete necrotic cell death namespace: biological_process def: "OBSOLETE. A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910] comment: The reason for obsoletion is that this term represent an assay and not a GO process.\n The reason for obsoletion is that this represents a phenotype. synonym: "cellular necrosis" EXACT [GOC:add] synonym: "necrosis" BROAD [GOC:mah] property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24680" xsd:anyURI is_obsolete: true [Term] id: GO:0070382 name: exocytic vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT [] synonym: "exocytotic vesicle" EXACT [GOC:kad] is_a: GO:0030133 ! transport vesicle is_a: GO:0099503 ! secretory vesicle intersection_of: GO:0030133 ! transport vesicle intersection_of: capable_of GO:0099500 ! vesicle fusion to plasma membrane [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization created_by: mah creation_date: 2009-06-16T04:08:29Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0043226 ! organelle relationship: results_in_assembly_of GO:0043226 ! organelle created_by: mah creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0071554 name: cell wall organization or biogenesis namespace: biological_process alt_id: GO:0070882 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular cell wall organization or biogenesis" EXACT [] is_a: GO:0009987 ! cellular process created_by: mah creation_date: 2010-01-13T03:19:38Z [Term] id: GO:0071555 name: cell wall organization namespace: biological_process alt_id: GO:0007047 alt_id: GO:0044234 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah] subset: goslim_candida subset: goslim_pir synonym: "cell wall organisation" EXACT [] synonym: "cell wall organisation in other organism" EXACT [GOC:mah] synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "cell wall organization at cellular level" EXACT [GOC:mah] synonym: "cell wall organization in other organism" EXACT [] synonym: "cellular cell wall organisation" EXACT [] synonym: "cellular cell wall organization" EXACT [] is_a: GO:0045229 ! external encapsulating structure organization is_a: GO:0071554 ! cell wall organization or biogenesis created_by: mah creation_date: 2010-01-13T03:33:07Z [Term] id: GO:0071692 name: protein localization to extracellular region namespace: biological_process def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] synonym: "protein localisation in extracellular region" EXACT [GOC:mah] synonym: "protein localization in extracellular region" EXACT [] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0005576 ! extracellular region relationship: has_target_end_location GO:0005576 ! extracellular region created_by: mah creation_date: 2010-02-25T04:00:13Z [Term] id: GO:0071702 name: organic substance transport namespace: biological_process def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:50860 ! organic molecular entity relationship: has_primary_input CHEBI:50860 ! organic molecular entity created_by: mah creation_date: 2010-03-08T02:15:14Z [Term] id: GO:0071704 name: organic substance metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah] subset: gocheck_do_not_annotate synonym: "organic molecular entity metabolic process" EXACT [] synonym: "organic molecular entity metabolism" EXACT [] synonym: "organic substance metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:50860 ! organic molecular entity relationship: has_primary_input_or_output CHEBI:50860 ! organic molecular entity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI created_by: mah creation_date: 2010-03-08T03:32:18Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:51143 ! nitrogen molecular entity relationship: has_primary_input CHEBI:51143 ! nitrogen molecular entity created_by: mah creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071709 name: membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0016020 ! membrane relationship: part_of GO:0044091 ! membrane biogenesis relationship: results_in_assembly_of GO:0016020 ! membrane created_by: mah creation_date: 2010-03-10T11:19:17Z [Term] id: GO:0071763 name: nuclear membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] synonym: "nuclear membrane organisation" EXACT [GOC:mah] synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0031965 ! nuclear membrane relationship: part_of GO:0006998 ! nuclear envelope organization relationship: results_in_organization_of GO:0031965 ! nuclear membrane created_by: mah creation_date: 2010-03-29T03:59:35Z [Term] id: GO:0071826 name: protein-RNA complex organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organization" EXACT [] synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:1990904 ! ribonucleoprotein complex relationship: results_in_organization_of GO:1990904 ! ribonucleoprotein complex property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25143" xsd:anyURI created_by: mah creation_date: 2010-09-08T10:10:35Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0009987 ! cellular process created_by: mah creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] subset: goslim_flybase_ribbon is_a: GO:0110165 ! cellular anatomical entity created_by: mah creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0072593 name: reactive oxygen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah] synonym: "reactive oxygen species metabolism" EXACT [GOC:mah] synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah] is_a: GO:0044237 ! cellular metabolic process created_by: mah creation_date: 2011-02-11T10:50:06Z [Term] id: GO:0072594 name: establishment of protein localization to organelle namespace: biological_process def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle is_a: GO:0045184 ! establishment of protein localization intersection_of: GO:0045184 ! establishment of protein localization intersection_of: has_target_end_location GO:0043226 ! organelle created_by: mah creation_date: 2011-02-14T01:56:51Z [Term] id: GO:0072657 name: protein localization to membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] subset: prokaryote_subset synonym: "protein localisation in membrane" EXACT [GOC:mah] synonym: "protein localization in membrane" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051668 ! localization within membrane intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0016020 ! membrane created_by: mah creation_date: 2011-02-14T02:35:18Z [Term] id: GO:0072659 name: protein localization to plasma membrane namespace: biological_process alt_id: GO:0072661 alt_id: GO:0090002 def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] subset: goslim_generic subset: goslim_pombe synonym: "protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "protein localization in plasma membrane" RELATED [] synonym: "protein targeting to plasma membrane" RELATED [] synonym: "protein-plasma membrane targeting" RELATED [GOC:mah] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0005886 ! plasma membrane intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure relationship: has_target_end_location GO:0005886 ! plasma membrane relationship: has_target_start_location GO:0005622 ! intracellular anatomical structure created_by: tb creation_date: 2009-07-10T10:29:23Z [Term] id: GO:0072665 name: protein localization to vacuole namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] synonym: "protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0005773 ! vacuole relationship: has_target_end_location GO:0005773 ! vacuole created_by: mah creation_date: 2011-02-14T02:55:35Z [Term] id: GO:0072666 name: establishment of protein localization to vacuole namespace: biological_process def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0045184 ! establishment of protein localization intersection_of: has_target_end_location GO:0005773 ! vacuole created_by: mah creation_date: 2011-02-14T02:56:29Z [Term] id: GO:0072697 name: protein localization to cell cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah] synonym: "protein localisation to cell cortex" EXACT [GOC:mah] is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0005938 ! cell cortex relationship: has_target_end_location GO:0005938 ! cell cortex created_by: mah creation_date: 2012-04-11T01:16:33Z [Term] id: GO:0075009 name: germ tube formation namespace: biological_process def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "germ tube formation on or near host" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009847 ! spore germination [Term] id: GO:0075015 name: formation of infection structure namespace: biological_process def: "The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. synonym: "formation by symbiont of infection structure on or near host" RELATED [] synonym: "formation of host infection structure" EXACT [] synonym: "formation of host penetration structure" RELATED [] synonym: "formation of infection structure on or near host" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0044409 ! entry into host property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19014" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20472" xsd:anyURI [Term] id: GO:0075053 name: penetration peg formation namespace: biological_process alt_id: GO:0075057 def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:26441323] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "formation of symbiont penetration peg for entry into host" RELATED [] synonym: "initiation of symbiont penetration peg" NARROW [] synonym: "symbiont penetration peg formation for entry into host" RELATED [] synonym: "symbiont penetration peg initiation" NARROW [] is_a: GO:0075015 ! formation of infection structure property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18557" xsd:anyURI [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044238 ! primary metabolic process relationship: regulates GO:0044238 ! primary metabolic process created_by: dhl creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0085030 name: mutualism name: symbiotic process benefiting host namespace: biological_process def: "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism." [GOC:pdt] def: "An interaction between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other." [] synonym: "mutualism" RELATED [] is_a: GO:0044403 ! biological process involved in symbiotic interaction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2010-07-27T01:25:21Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0022402 ! cell cycle process relationship: positively_regulates GO:0022402 ! cell cycle process created_by: tb creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015833 ! peptide transport relationship: regulates GO:0015833 ! peptide transport created_by: tb creation_date: 2009-10-23T11:21:38Z [Term] id: GO:0090150 name: establishment of protein localization to membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in membrane" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0072657 ! protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: has_target_end_location GO:0016020 ! membrane created_by: tb creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090174 name: organelle membrane fusion namespace: biological_process def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048284 ! organelle fusion is_a: GO:0061025 ! membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: results_in_fusion_of GO:0031090 ! organelle membrane relationship: results_in_fusion_of GO:0031090 ! organelle membrane created_by: tb creation_date: 2009-12-11T11:44:58Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:33696 ! nucleic acid relationship: has_primary_input_or_output CHEBI:33696 ! nucleic acid created_by: tb creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006886 ! intracellular protein transport relationship: positively_regulates GO:0006886 ! intracellular protein transport created_by: tb creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006886 ! intracellular protein transport relationship: negatively_regulates GO:0006886 ! intracellular protein transport created_by: tb creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090435 name: protein localization to nuclear envelope namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb] synonym: "protein localization in nuclear envelope" EXACT [] is_a: GO:0034504 ! protein localization to nucleus intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0005635 ! nuclear envelope relationship: has_target_end_location GO:0005635 ! nuclear envelope created_by: tb creation_date: 2012-07-30T01:50:41Z [Term] id: GO:0090685 name: RNA localization to nucleus namespace: biological_process def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] synonym: "RNA localisation to nucleus" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: has_target_end_location GO:0005634 ! nucleus relationship: has_target_end_location GO:0005634 ! nucleus created_by: tb creation_date: 2016-07-19T17:00:49Z [Term] id: GO:0097159 name: organic cyclic compound binding namespace: molecular_function def: "Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672] is_a: GO:0005488 ! binding created_by: pr creation_date: 2011-09-23T02:31:01Z [Term] id: GO:0097164 name: ammonium ion metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the ammonium ion." [GOC:dhl, GOC:tb, PMID:14671018] synonym: "ammonium ion metabolism" EXACT [] synonym: "ammonium metabolic process" RELATED [] is_a: GO:0006807 ! nitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:28938 ! ammonium relationship: has_primary_input_or_output CHEBI:28938 ! ammonium created_by: pr creation_date: 2011-09-28T04:21:30Z [Term] id: GO:0097176 name: epoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [GOC:rs, PMID:15822179] synonym: "epoxide metabolism" EXACT [] is_a: GO:0018904 ! ether metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: pr creation_date: 2011-10-10T11:29:49Z [Term] id: GO:0097367 name: carbohydrate derivative binding namespace: molecular_function def: "Binding to a carbohydrate derivative." [GOC:pr] subset: goslim_agr subset: goslim_mouse is_a: GO:0005488 ! binding created_by: pr creation_date: 2012-08-02T13:03:39Z [Term] id: GO:0097576 name: vacuole fusion namespace: biological_process def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole] is_a: GO:0007033 ! vacuole organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0009987 ! cellular process intersection_of: results_in_fusion_of GO:0005773 ! vacuole relationship: results_in_fusion_of GO:0005773 ! vacuole created_by: pr creation_date: 2014-02-28T09:49:31Z [Term] id: GO:0097708 name: intracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005622 ! intracellular anatomical structure created_by: pr creation_date: 2016-03-29T17:39:45Z [Term] id: GO:0098542 name: defense response to other organism namespace: biological_process alt_id: GO:0009814 def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] subset: goslim_generic subset: goslim_prokaryote synonym: "defence response incompatible interaction" NARROW [] synonym: "defence response to pathogen, incompatible interaction" NARROW [] synonym: "defense response, incompatible interaction" NARROW [] synonym: "resistance response to pathogen" NARROW [] is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22173" xsd:anyURI created_by: dos creation_date: 2013-11-11T12:59:11Z [Term] id: GO:0098590 name: plasma membrane region namespace: cellular_component def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_manually_annotate synonym: "region of plasma membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane created_by: dos creation_date: 2014-03-06T11:55:32Z [Term] id: GO:0098657 name: import into cell namespace: biological_process def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] synonym: "uptake" BROAD [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:24431 ! chemical entity intersection_of: has_target_end_location GO:0005737 ! cytoplasm intersection_of: has_target_start_location GO:0005576 ! extracellular region relationship: has_primary_input CHEBI:24431 ! chemical entity relationship: has_target_end_location GO:0005737 ! cytoplasm relationship: has_target_start_location GO:0005576 ! extracellular region [Term] id: GO:0098762 name: meiotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: happens_during GO:0051321 ! meiotic cell cycle relationship: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0098764 name: meiosis I cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane [Term] id: GO:0098797 name: plasma membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0098876 name: vesicle-mediated transport to the plasma membrane namespace: biological_process def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0051668 ! localization within membrane intersection_of: GO:0006810 ! transport intersection_of: has_target_end_location GO:0005886 ! plasma membrane intersection_of: process_has_causal_agent GO:0031982 ! vesicle relationship: ends_with GO:0006887 ! exocytosis relationship: has_target_end_location GO:0005886 ! plasma membrane [Term] id: GO:0099500 name: vesicle fusion to plasma membrane namespace: biological_process def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] is_a: GO:0006906 ! vesicle fusion is_a: GO:0140029 ! exocytic process intersection_of: GO:0061025 ! membrane fusion intersection_of: part_of GO:0006887 ! exocytosis intersection_of: results_in_fusion_of GO:0012506 ! vesicle membrane intersection_of: results_in_fusion_of GO:0098590 ! plasma membrane region relationship: results_in_fusion_of GO:0098590 ! plasma membrane region [Term] id: GO:0099503 name: secretory vesicle namespace: cellular_component def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] subset: goslim_drosophila is_a: GO:0031410 ! cytoplasmic vesicle intersection_of: GO:0031982 ! vesicle intersection_of: capable_of GO:0099500 ! vesicle fusion to plasma membrane relationship: capable_of GO:0099500 ! vesicle fusion to plasma membrane [Term] id: GO:0099568 name: cytoplasmic region namespace: cellular_component def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] subset: gocheck_do_not_annotate is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0099632 name: protein transport within plasma membrane namespace: biological_process def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos] is_a: GO:0032594 ! protein transport within lipid bilayer intersection_of: GO:0006810 ! transport intersection_of: has_primary_input PR:000000001 ! protein intersection_of: occurs_in GO:0005886 ! plasma membrane relationship: occurs_in GO:0005886 ! plasma membrane [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos] subset: gocheck_do_not_annotate synonym: "perimembrane region" EXACT [] is_a: GO:0005938 ! cell cortex is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005938 ! cell cortex intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0101025 name: nuclear membrane biogenesis namespace: biological_process def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw] is_a: GO:0044091 ! membrane biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: has_output GO:0031965 ! nuclear membrane relationship: has_output GO:0031965 ! nuclear membrane relationship: part_of GO:0071763 ! nuclear membrane organization [Term] id: GO:0106110 name: vomitoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats." [http://www.inchem.org/documents/jecfa/jecmono/v47je05.htm, https://doi.org/10.1007/BF03356188, PMID:19333439, PMID:25680507, PMID:25758923, PMID:8637056] synonym: "deoxynivalenol biosynthetic process" EXACT [] synonym: "DON biosynthetic process" EXACT [] synonym: "vomitoxin anabolism" EXACT [] synonym: "vomitoxin biosynthesis" EXACT [] synonym: "vomitoxin formation" EXACT [] synonym: "vomitoxin synthesis" EXACT [] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0097176 ! epoxide metabolic process is_a: GO:0120255 ! olefinic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: hjd creation_date: 2018-04-16T19:06:06Z [Term] id: GO:0106259 name: cell-to-cell migration in host namespace: biological_process def: "The directional movement of a symbiont from one host cell to another." [GOC:vw, PMID:29567712] is_a: GO:0044001 ! migration in host created_by: hjd creation_date: 2020-05-01T14:09:35Z [Term] id: GO:0110112 name: regulation of lipid transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] subset: term_scheduled_for_obsoletion is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032409 ! regulation of transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005319 ! lipid transporter activity relationship: regulates GO:0005319 ! lipid transporter activity created_by: kmv creation_date: 2018-07-06T18:53:55Z [Term] id: GO:0110113 name: positive regulation of lipid transporter activity namespace: biological_process def: "Any process that increases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] subset: term_scheduled_for_obsoletion is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0110112 ! regulation of lipid transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0005319 ! lipid transporter activity relationship: positively_regulates GO:0005319 ! lipid transporter activity created_by: kmv creation_date: 2018-07-06T19:14:13Z [Term] id: GO:0110114 name: negative regulation of lipid transporter activity namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] subset: term_scheduled_for_obsoletion is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0110112 ! regulation of lipid transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0005319 ! lipid transporter activity relationship: negatively_regulates GO:0005319 ! lipid transporter activity created_by: kmv creation_date: 2018-07-06T19:21:44Z [Term] id: GO:0110165 name: cellular anatomical entity namespace: cellular_component def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv] subset: gocheck_do_not_annotate subset: goslim_pir is_a: GO:0005575 ! cellular_component property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI created_by: kmv creation_date: 2019-08-12T18:01:37Z [Term] id: GO:0120254 name: olefinic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] synonym: "alkene substituted compound metabolic process" EXACT [] synonym: "alkene substituted compound metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19936" xsd:anyURI created_by: krc creation_date: 2020-09-02T23:13:44Z [Term] id: GO:0120255 name: olefinic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] synonym: "alkene substituted compound anabolic process" EXACT [GOC:krc] synonym: "alkene substituted compound anabolism" EXACT [GOC:krc] synonym: "alkene substituted compound biosynthesis" EXACT [GOC:krc] synonym: "alkene substituted compound biosynthetic process" EXACT [GOC:krc] synonym: "alkene substituted compound synthesis" EXACT [GOC:krc] is_a: GO:0120254 ! olefinic compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19936" xsd:anyURI created_by: krc creation_date: 2020-09-02T23:30:20Z [Term] id: GO:0140013 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] subset: goslim_generic synonym: "meiosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19910" xsd:anyURI created_by: pg creation_date: 2017-03-23T09:40:00Z [Term] id: GO:0140029 name: exocytic process namespace: biological_process def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0006887 ! exocytosis relationship: part_of GO:0006887 ! exocytosis created_by: pg creation_date: 2017-05-15T13:20:45Z [Term] id: GO:0140096 name: catalytic activity, acting on a protein namespace: molecular_function def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: goslim_prokaryote subset: prokaryote_subset is_a: GO:0003824 ! catalytic activity intersection_of: GO:0003824 ! catalytic activity intersection_of: has_input PR:000000001 ! protein relationship: has_input PR:000000001 ! protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI created_by: pg creation_date: 2017-09-14T10:32:59Z [Term] id: GO:0140098 name: catalytic activity, acting on RNA namespace: molecular_function def: "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: prokaryote_subset is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid intersection_of: GO:0003824 ! catalytic activity intersection_of: has_input CHEBI:33697 ! ribonucleic acid relationship: has_input CHEBI:33697 ! ribonucleic acid property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI created_by: pg creation_date: 2017-09-14T12:05:21Z [Term] id: GO:0140272 name: exogenous protein binding namespace: molecular_function def: "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein." [PMID:28861068] comment: Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant. is_a: GO:0005515 ! protein binding created_by: pg creation_date: 2018-10-01T10:03:21Z [Term] id: GO:0140318 name: protein transporter activity namespace: molecular_function def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423] comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. synonym: "protein carrier activity" RELATED [] synonym: "protein transport chaperone" RELATED [] xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network" xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: has_primary_input PR:000000001 ! protein relationship: has_primary_input PR:000000001 ! protein property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17073" xsd:anyURI created_by: pg creation_date: 2019-04-01T10:41:38Z [Term] id: GO:0140352 name: export from cell namespace: biological_process def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: has_target_end_location GO:0005576 ! extracellular region intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure relationship: has_target_end_location GO:0005576 ! extracellular region relationship: has_target_start_location GO:0005622 ! intracellular anatomical structure created_by: pg creation_date: 2019-05-22T11:20:45Z [Term] id: GO:0140353 name: lipid export from cell namespace: biological_process def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg] synonym: "lipid efflux" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0140352 ! export from cell intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:18059 ! lipid intersection_of: has_target_end_location GO:0005576 ! extracellular region intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure created_by: pg creation_date: 2019-05-22T11:33:07Z [Term] id: GO:0140354 name: lipid import into cell namespace: biological_process def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg] synonym: "lipid uptake" BROAD [] is_a: GO:0006869 ! lipid transport intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:18059 ! lipid intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure intersection_of: has_target_start_location GO:0005576 ! extracellular region relationship: has_target_end_location GO:0005622 ! intracellular anatomical structure relationship: has_target_start_location GO:0005576 ! extracellular region created_by: pg creation_date: 2019-05-22T11:38:15Z [Term] id: GO:0140513 name: nuclear protein-containing complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] subset: gocheck_do_not_annotate synonym: "nuclear complex" EXACT [] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus created_by: pg creation_date: 2020-09-09T05:12:38Z [Term] id: GO:0140546 name: defense response to symbiont namespace: biological_process def: "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] is_a: GO:0098542 ! defense response to other organism property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20261" xsd:anyURI created_by: pg creation_date: 2020-11-11T17:19:06Z [Term] id: GO:0140572 name: vacuole fission namespace: biological_process def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: results_in_fission_of GO:0005773 ! vacuole relationship: results_in_fission_of GO:0005773 ! vacuole property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20639" xsd:anyURI created_by: pg creation_date: 2021-01-04T10:17:58Z [Term] id: GO:0140640 name: catalytic activity, acting on a nucleic acid namespace: molecular_function def: "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] is_a: GO:0003824 ! catalytic activity intersection_of: GO:0003824 ! catalytic activity intersection_of: has_input CHEBI:33696 ! nucleic acid relationship: has_input CHEBI:33696 ! nucleic acid property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21402" xsd:anyURI created_by: pg creation_date: 2021-05-11T06:31:07Z [Term] id: GO:0140657 name: ATP-dependent activity namespace: molecular_function def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "ATP hydrolysis-dependent activity" EXACT [] synonym: "ATPase activity" EXACT [] synonym: "ATPase activity, coupled" EXACT [] synonym: "ATPase-dependent activity" EXACT [] is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: has_part GO:0016887 ! ATP hydrolysis activity relationship: has_part GO:0016887 ! ATP hydrolysis activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI created_by: pg creation_date: 2021-06-15T07:35:06Z [Term] id: GO:0170033 name: L-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an L-amino acid." [GOC:edw] synonym: "L-alpha-amino acid metabolism" EXACT [] synonym: "L-amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI created_by: ew creation_date: 2023-11-20T23:41:23Z [Term] id: GO:0170034 name: L-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw] synonym: "L-amino acid anabolism" EXACT [] synonym: "L-amino acid biosynthesis" EXACT [] synonym: "L-amino acid formation" EXACT [] synonym: "L-amino acid synthesis" EXACT [] is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI created_by: ew creation_date: 2023-11-20T23:42:06Z [Term] id: GO:0170038 name: proteinogenic amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid anabolism" EXACT [] synonym: "proteinogenic amino acid biosynthesis" EXACT [] synonym: "proteinogenic amino acid formation" EXACT [] synonym: "proteinogenic amino acid synthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI created_by: ew creation_date: 2023-12-18T16:28:19Z [Term] id: GO:0170039 name: proteinogenic amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid metabolism" EXACT [] is_a: GO:0006520 ! amino acid metabolic process property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23268" xsd:anyURI created_by: ew creation_date: 2023-12-18T17:31:08Z [Term] id: GO:1900180 name: regulation of protein localization to nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034504 ! protein localization to nucleus relationship: regulates GO:0034504 ! protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:44Z [Term] id: GO:1900181 name: negative regulation of protein localization to nucleus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0034504 ! protein localization to nucleus relationship: negatively_regulates GO:0034504 ! protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:48Z [Term] id: GO:1900182 name: positive regulation of protein localization to nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0034504 ! protein localization to nucleus relationship: positively_regulates GO:0034504 ! protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:52Z [Term] id: GO:1901190 name: regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001677 ! formation of translation initiation ternary complex relationship: regulates GO:0001677 ! formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:26:58Z [Term] id: GO:1901191 name: negative regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex relationship: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:27:21Z [Term] id: GO:1901192 name: positive regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001677 ! formation of translation initiation ternary complex relationship: positively_regulates GO:0001677 ! formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:27:29Z [Term] id: GO:1901360 name: organic cyclic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:33832 ! organic cyclic compound relationship: has_primary_input_or_output CHEBI:33832 ! organic cyclic compound created_by: bf creation_date: 2012-09-14T09:03:51Z [Term] id: GO:1901361 name: organic cyclic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie] synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901575 ! organic substance catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:33832 ! organic cyclic compound relationship: has_primary_input CHEBI:33832 ! organic cyclic compound created_by: bf creation_date: 2012-09-14T09:05:04Z [Term] id: GO:1901362 name: organic cyclic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie] synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33832 ! organic cyclic compound relationship: has_primary_output CHEBI:33832 ! organic cyclic compound created_by: bf creation_date: 2012-09-14T09:05:22Z [Term] id: GO:1901503 name: ether biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ether." [GOC:pr, GOC:TermGenie] synonym: "ether anabolism" EXACT [GOC:TermGenie] synonym: "ether biosynthesis" EXACT [GOC:TermGenie] synonym: "ether formation" EXACT [GOC:TermGenie] synonym: "ether synthesis" EXACT [GOC:TermGenie] is_a: GO:0018904 ! ether metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: pr creation_date: 2012-10-17T09:42:47Z [Term] id: GO:1901564 name: organonitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:35352 ! organonitrogen compound relationship: has_primary_input_or_output CHEBI:35352 ! organonitrogen compound property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI created_by: pr creation_date: 2012-11-04T15:17:52Z [Term] id: GO:1901565 name: organonitrogen compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound breakdown" EXACT [GOC:TermGenie] synonym: "organonitrogen compound catabolism" EXACT [GOC:TermGenie] synonym: "organonitrogen compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901575 ! organic substance catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:35352 ! organonitrogen compound relationship: has_primary_input CHEBI:35352 ! organonitrogen compound created_by: pr creation_date: 2012-11-04T15:17:56Z [Term] id: GO:1901566 name: organonitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie] synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie] synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:35352 ! organonitrogen compound relationship: has_primary_output CHEBI:35352 ! organonitrogen compound created_by: pr creation_date: 2012-11-04T15:18:00Z [Term] id: GO:1901575 name: organic substance catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity breakdown" EXACT [GOC:TermGenie] synonym: "organic molecular entity catabolic process" EXACT [] synonym: "organic molecular entity catabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity degradation" EXACT [GOC:TermGenie] synonym: "organic substance breakdown" EXACT [] synonym: "organic substance catabolism" EXACT [] synonym: "organic substance degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:50860 ! organic molecular entity relationship: has_primary_input CHEBI:50860 ! organic molecular entity created_by: pr creation_date: 2012-11-05T11:04:36Z [Term] id: GO:1901576 name: organic substance biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthetic process" EXACT [] synonym: "organic molecular entity formation" EXACT [GOC:TermGenie] synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie] synonym: "organic substance anabolism" EXACT [] synonym: "organic substance biosynthesis" EXACT [] synonym: "organic substance formation" EXACT [] synonym: "organic substance synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:50860 ! organic molecular entity relationship: has_primary_output CHEBI:50860 ! organic molecular entity created_by: pr creation_date: 2012-11-05T11:04:40Z [Term] id: GO:1901605 name: alpha-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0006520 ! amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:78608 ! alpha-amino acid zwitterion relationship: has_primary_input_or_output CHEBI:78608 ! alpha-amino acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:50Z [Term] id: GO:1901606 name: alpha-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] is_a: GO:1901575 ! organic substance catabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: has_primary_input CHEBI:78608 ! alpha-amino acid zwitterion relationship: has_primary_input CHEBI:78608 ! alpha-amino acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:54Z [Term] id: GO:1901607 name: alpha-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie] synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:78608 ! alpha-amino acid zwitterion relationship: has_primary_output CHEBI:78608 ! alpha-amino acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:58Z [Term] id: GO:1901615 name: organic hydroxy compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-13T12:54:27Z [Term] id: GO:1901617 name: organic hydroxy compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound anabolism" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound formation" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901576 ! organic substance biosynthetic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: pr creation_date: 2012-11-13T12:54:36Z [Term] id: GO:1902115 name: regulation of organelle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070925 ! organelle assembly relationship: regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:21Z [Term] id: GO:1902116 name: negative regulation of organelle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0070925 ! organelle assembly relationship: negatively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:31Z [Term] id: GO:1902117 name: positive regulation of organelle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0070925 ! organelle assembly relationship: positively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:36Z [Term] id: GO:1902369 name: negative regulation of RNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006401 ! RNA catabolic process relationship: negatively_regulates GO:0006401 ! RNA catabolic process created_by: bf creation_date: 2013-08-22T14:59:39Z [Term] id: GO:1902494 name: catalytic complex namespace: cellular_component def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] subset: goslim_metagenomics synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: capable_of GO:0003824 ! catalytic activity relationship: capable_of GO:0003824 ! catalytic activity property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19980" xsd:anyURI created_by: bhm creation_date: 2013-11-13T16:18:47Z [Term] id: GO:1902652 name: secondary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "secondary alcohol metabolism" EXACT [GOC:TermGenie] is_a: GO:0006066 ! alcohol metabolic process created_by: tt creation_date: 2014-01-22T10:14:52Z [Term] id: GO:1902653 name: secondary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "secondary alcohol anabolism" EXACT [GOC:TermGenie] synonym: "secondary alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "secondary alcohol formation" EXACT [GOC:TermGenie] synonym: "secondary alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: tt creation_date: 2014-01-22T10:15:02Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032774 ! RNA biosynthetic process relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032774 ! RNA biosynthetic process relationship: positively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1903008 name: organelle disassembly namespace: biological_process def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "organelle degradation" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:0043226 ! organelle relationship: results_in_disassembly_of GO:0043226 ! organelle created_by: jl creation_date: 2014-05-13T12:36:03Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate subset: goslim_pombe is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903076 name: regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090003 alt_id: GO:1905963 def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein targeting to plasma membrane" RELATED [] synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072659 ! protein localization to plasma membrane relationship: regulates GO:0072659 ! protein localization to plasma membrane created_by: tb creation_date: 2009-07-10T10:32:44Z [Term] id: GO:1903077 name: negative regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090005 alt_id: GO:1905964 def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein targeting to plasma membrane" RELATED [] synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072659 ! protein localization to plasma membrane relationship: negatively_regulates GO:0072659 ! protein localization to plasma membrane created_by: tb creation_date: 2014-05-29T17:10:16Z [Term] id: GO:1903078 name: positive regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090004 alt_id: GO:1905965 def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein targeting to plasma membrane" RELATED [] synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072659 ! protein localization to plasma membrane relationship: positively_regulates GO:0072659 ! protein localization to plasma membrane created_by: tb creation_date: 2009-07-10T10:34:17Z [Term] id: GO:1903335 name: regulation of vacuolar transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007034 ! vacuolar transport relationship: regulates GO:0007034 ! vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:04Z [Term] id: GO:1903336 name: negative regulation of vacuolar transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007034 ! vacuolar transport relationship: negatively_regulates GO:0007034 ! vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:11Z [Term] id: GO:1903337 name: positive regulation of vacuolar transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie] synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007034 ! vacuolar transport relationship: positively_regulates GO:0007034 ! vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:19Z [Term] id: GO:1903353 name: regulation of nucleus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282] synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie] synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006997 ! nucleus organization relationship: regulates GO:0006997 ! nucleus organization created_by: hjd creation_date: 2014-08-20T19:36:16Z [Term] id: GO:1903409 name: reactive oxygen species biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "reactive oxygen species generation" RELATED [PMID:24252804] synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "ROS formation" RELATED [] synonym: "ROS generation" RELATED [PMID:24252804] is_a: GO:0009058 ! biosynthetic process is_a: GO:0072593 ! reactive oxygen species metabolic process created_by: bf creation_date: 2014-09-03T09:19:13Z [Term] id: GO:1903530 name: regulation of secretion by cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032940 ! secretion by cell relationship: regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:24:59Z [Term] id: GO:1903531 name: negative regulation of secretion by cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032940 ! secretion by cell relationship: negatively_regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:25:08Z [Term] id: GO:1903532 name: positive regulation of secretion by cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "activation of cellular secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion by cell" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032940 ! secretion by cell relationship: positively_regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:25:17Z [Term] id: GO:1903561 name: extracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] synonym: "microparticle" RELATED [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0065010 ! extracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005576 ! extracellular region created_by: jl creation_date: 2014-10-22T14:26:11Z [Term] id: GO:1903729 name: regulation of plasma membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie] synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007009 ! plasma membrane organization relationship: regulates GO:0007009 ! plasma membrane organization created_by: al creation_date: 2014-12-10T18:59:44Z [Term] id: GO:1903828 name: negative regulation of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein localization" EXACT [] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008104 ! protein localization relationship: negatively_regulates GO:0008104 ! protein localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI created_by: jl creation_date: 2015-01-20T14:32:24Z [Term] id: GO:1903829 name: positive regulation of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein localization" EXACT [] synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008104 ! protein localization relationship: positively_regulates GO:0008104 ! protein localization property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI created_by: jl creation_date: 2015-01-20T14:32:33Z [Term] id: GO:1904350 name: regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007039 ! protein catabolic process in the vacuole relationship: regulates GO:0007039 ! protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:36Z [Term] id: GO:1904351 name: negative regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole relationship: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:42Z [Term] id: GO:1904352 name: positive regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007039 ! protein catabolic process in the vacuole relationship: positively_regulates GO:0007039 ! protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:49Z [Term] id: GO:1904375 name: regulation of protein localization to cell periphery namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1990778 ! protein localization to cell periphery relationship: regulates GO:1990778 ! protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:25Z [Term] id: GO:1904376 name: negative regulation of protein localization to cell periphery namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1990778 ! protein localization to cell periphery relationship: negatively_regulates GO:1990778 ! protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:32Z [Term] id: GO:1904377 name: positive regulation of protein localization to cell periphery namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1990778 ! protein localization to cell periphery relationship: positively_regulates GO:1990778 ! protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:37Z [Term] id: GO:1904776 name: regulation of protein localization to cell cortex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072697 ! protein localization to cell cortex relationship: regulates GO:0072697 ! protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:01Z [Term] id: GO:1904777 name: negative regulation of protein localization to cell cortex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072697 ! protein localization to cell cortex relationship: negatively_regulates GO:0072697 ! protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:08Z [Term] id: GO:1904778 name: positive regulation of protein localization to cell cortex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072697 ! protein localization to cell cortex relationship: positively_regulates GO:0072697 ! protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:15Z [Term] id: GO:1904950 name: negative regulation of establishment of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0045184 ! establishment of protein localization relationship: negatively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:24Z [Term] id: GO:1904951 name: positive regulation of establishment of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "activation of protein positioning" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0045184 ! establishment of protein localization relationship: positively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:32Z [Term] id: GO:1905037 name: autophagosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie] synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie] is_a: GO:0007033 ! vacuole organization relationship: part_of GO:0016236 ! macroautophagy created_by: bf creation_date: 2016-03-08T14:18:10Z [Term] id: GO:1905153 name: regulation of membrane invagination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010324 ! membrane invagination relationship: regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:43:54Z [Term] id: GO:1905154 name: negative regulation of membrane invagination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010324 ! membrane invagination relationship: negatively_regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:44:04Z [Term] id: GO:1905155 name: positive regulation of membrane invagination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of membrane invagination" NARROW [GOC:TermGenie] synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010324 ! membrane invagination relationship: positively_regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:44:12Z [Term] id: GO:1905475 name: regulation of protein localization to membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072657 ! protein localization to membrane relationship: regulates GO:0072657 ! protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:03Z [Term] id: GO:1905476 name: negative regulation of protein localization to membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072657 ! protein localization to membrane relationship: negatively_regulates GO:0072657 ! protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:10Z [Term] id: GO:1905477 name: positive regulation of protein localization to membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072657 ! protein localization to membrane relationship: positively_regulates GO:0072657 ! protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:18Z [Term] id: GO:1905690 name: nucleus disassembly namespace: biological_process def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie] is_a: GO:0006997 ! nucleus organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:0005634 ! nucleus relationship: results_in_disassembly_of GO:0005634 ! nucleus created_by: pr creation_date: 2016-11-14T13:38:57Z [Term] id: GO:1905952 name: regulation of lipid localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010876 ! lipid localization relationship: regulates GO:0010876 ! lipid localization created_by: rz creation_date: 2017-02-21T12:12:22Z [Term] id: GO:1905953 name: negative regulation of lipid localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie] synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie] synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010876 ! lipid localization relationship: negatively_regulates GO:0010876 ! lipid localization created_by: rz creation_date: 2017-02-21T12:12:41Z [Term] id: GO:1905954 name: positive regulation of lipid localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "activation of lipid localisation" NARROW [GOC:TermGenie] synonym: "activation of lipid localization" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010876 ! lipid localization relationship: positively_regulates GO:0010876 ! lipid localization created_by: rz creation_date: 2017-02-21T12:12:49Z [Term] id: GO:1990234 name: transferase complex namespace: cellular_component def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] is_a: GO:1902494 ! catalytic complex intersection_of: GO:1902494 ! catalytic complex intersection_of: capable_of GO:0016740 ! transferase activity relationship: capable_of GO:0016740 ! transferase activity created_by: bhm creation_date: 2013-11-12T13:20:12Z [Term] id: GO:1990351 name: transporter complex namespace: cellular_component def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: capable_of GO:0005215 ! transporter activity relationship: capable_of GO:0005215 ! transporter activity created_by: bhm creation_date: 2014-03-26T14:23:27Z [Term] id: GO:1990778 name: protein localization to cell periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0071944 ! cell periphery relationship: has_target_end_location GO:0071944 ! cell periphery creation_date: 2015-06-18T22:37:39Z [Term] id: GO:1990849 name: vacuolar localization namespace: biological_process def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797] synonym: "maintenance of vacuolar localization" EXACT [] synonym: "maintenance of vacuolar location" NARROW [] synonym: "maintenance of vacuole localization" EXACT [] synonym: "maintenance of vacuole location" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: has_primary_input GO:0005773 ! vacuole relationship: has_primary_input GO:0005773 ! vacuole property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22182" xsd:anyURI created_by: mcc creation_date: 2015-09-10T08:16:02Z [Term] id: GO:1990904 name: ribonucleoprotein complex namespace: cellular_component alt_id: GO:0030529 alt_id: GO:1990903 def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] subset: goslim_pir synonym: "extracellular ribonucleoprotein complex" NARROW [] synonym: "intracellular ribonucleoprotein complex" NARROW [] synonym: "protein-RNA complex" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex relationship: has_part CHEBI:33697 ! ribonucleic acid created_by: pr creation_date: 2015-11-19T12:26:37Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022414 ! reproductive process relationship: regulates GO:0022414 ! reproductive process created_by: mah creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0022414 ! reproductive process relationship: negatively_regulates GO:0022414 ! reproductive process created_by: mah creation_date: 2010-11-10T02:44:05Z [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0022414 ! reproductive process relationship: positively_regulates GO:0022414 ! reproductive process created_by: mah creation_date: 2010-11-10T02:44:08Z [Term] id: GO:2000282 name: regulation of cellular amino acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "regulation of amino acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008652 ! amino acid biosynthetic process relationship: regulates GO:0008652 ! amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:19Z [Term] id: GO:2000283 name: negative regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process." [GOC:obol] synonym: "negative regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of amino acid formation" EXACT [GOC:obol] synonym: "negative regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008652 ! amino acid biosynthetic process relationship: negatively_regulates GO:0008652 ! amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:23Z [Term] id: GO:2000284 name: positive regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "positive regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "positive regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of amino acid formation" EXACT [GOC:obol] synonym: "positive regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045764 ! positive regulation of amino acid metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008652 ! amino acid biosynthetic process relationship: positively_regulates GO:0008652 ! amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:27Z [Term] id: GO:2001141 name: regulation of RNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032774 ! RNA biosynthetic process relationship: regulates GO:0032774 ! RNA biosynthetic process created_by: dph creation_date: 2011-10-17T11:36:25Z [Term] id: IAO:0000027 name: data item is_a: IAO:0000030 ! information content entity [Term] id: IAO:0000030 name: information content entity is_a: BFO:0000031 ! generically dependent continuant [Term] id: IAO:0000078 name: curation status specification def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part property_value: IAO:0000111 "curation status specification" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string property_value: IAO:0000117 "PERSON:Bill Bug" xsd:string property_value: IAO:0000119 "GROUP:OBI:" xsd:string property_value: IAO:0000119 "OBI_0000266" xsd:string [Term] id: IAO:0000102 name: data about an ontology part def: "data about an ontology part is a data item about a part of an ontology, for example a term" [] is_a: IAO:0000027 ! data item property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string [Term] id: IAO:0000225 name: obsolescence reason specification def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part property_value: IAO:0000111 "obsolescence reason specification" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string [Term] id: IAO:0000409 name: denotator type def: "A denotator type indicates how a term should be interpreted from an ontological perspective." [] is_a: IAO:0000102 ! data about an ontology part property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string property_value: IAO:0000117 "Alan Ruttenberg" xsd:string property_value: IAO:0000119 "Barry Smith, Werner Ceusters" xsd:string [Term] id: IDO:0000450 name: pathogenic disposition def: "A disposition to initiate processes that result in a disorder." [] comment: A pathogenic disposition is realized in processes that create a disorder. comment: The use of 'initiates' is intended to convey that a pathogenic disposition is realized when processes resulting in a disorder begin because of some action on the part of the bearer of the disposition. By this interpretation of 'initiates', disorder-causing entities such as glass, UV light, and toxins do not have a pathogenic disposition. is_a: BFO:0000016 ! disposition property_value: IAO:0000117 "Albert Goldfain" xsd:string property_value: IAO:0000117 "Alexander Diehl" xsd:string property_value: IAO:0000117 "Lindsay Cowell" xsd:string property_value: IAO:0000118 "pathogenicity" xsd:string [Term] id: IDO:0000528 name: pathogen def: "A material entity with a pathogenic disposition." [] is_a: BFO:0000040 ! material entity intersection_of: BFO:0000040 ! material entity intersection_of: RO:0000091 IDO:0000450 ! has disposition pathogenic disposition relationship: RO:0000091 IDO:0000450 ! has disposition pathogenic disposition property_value: IAO:0000117 "Albert Goldfain" xsd:string property_value: IAO:0000117 "Alexander Diehl" xsd:string property_value: IAO:0000117 "Lindsay Cowell" xsd:string [Term] id: IDO:0000626 name: appearance of disorder def: "A process by which a disorder comes into existence." [] is_a: GO:0008150 ! biological_process relationship: results_in_formation_of OGMS:0000045 ! disorder property_value: IAO:0000117 "Albert Goldfain" xsd:string property_value: IAO:0000117 "Alexander Diehl" xsd:string property_value: IAO:0000117 "Lindsay Cowell" xsd:string [Term] id: NCBITaxon:1 name: root namespace: ncbi_taxonomy synonym: "all" RELATED synonym [] xref: GC_ID:1 is_a: OBI:0100026 [Term] id: NCBITaxon:131567 name: cellular organisms namespace: ncbi_taxonomy synonym: "biota" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:1 ! root [Term] id: NCBITaxon:2759 name: Eukaryota namespace: ncbi_taxonomy synonym: "Eucarya" RELATED synonym [] synonym: "Eucaryotae" RELATED synonym [] synonym: "eucaryotes" EXACT genbank_common_name [] synonym: "Eukarya" RELATED synonym [] synonym: "Eukaryotae" RELATED synonym [] synonym: "eukaryotes" EXACT common_name [] synonym: "eukaryotes" RELATED blast_name [] xref: GC_ID:1 xref: PMID:23020233 xref: PMID:30257078 is_a: NCBITaxon:131567 ! cellular organisms property_value: has_rank NCBITaxon:superkingdom [Term] id: NCBITaxon:33154 name: Opisthokonta namespace: ncbi_taxonomy synonym: "Fungi/Metazoa group" RELATED synonym [] synonym: "opisthokonts" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:4751 name: Fungi namespace: ncbi_taxonomy synonym: "fungi" RELATED blast_name [] synonym: "Mycota" RELATED synonym [] xref: GC_ID:1 xref: PMID:11062127 xref: PMID:12684019 is_a: NCBITaxon:33154 ! Opisthokonta property_value: has_rank NCBITaxon:kingdom [Term] id: OGMS:0000045 name: disorder def: "A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease." [] is_a: BFO:0000040 ! material entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/ogms.owl [Term] id: PATO:0000001 name: quality namespace: quality alt_id: PATO:0000072 def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG] is_a: BFO:0000020 ! specifically dependent continuant [Term] id: PATO:0000033 name: concentration of namespace: quality def: "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." [Wikipedia:http\://en.wikipedia.org/wiki/concentration] subset: attribute_slim subset: relational_slim subset: scalar_slim synonym: "concentration" EXACT [] is_a: PATO:0002182 ! molecular quality [Term] id: PATO:0000051 name: morphology namespace: quality def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0000052 name: shape namespace: quality alt_id: PATO:0001647 def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG] comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. subset: attribute_slim synonym: "relational shape quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000057 name: occurrence namespace: quality alt_id: PATO:0000156 alt_id: PATO:0000158 def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence." [PATOC:GVG] subset: attribute_slim subset: hpo_slim synonym: "incidence" EXACT [] synonym: "temporal" BROAD [] is_a: PATO:0002323 ! temporal distribution quality [Term] id: PATO:0000068 name: qualitative namespace: quality comment: TODO: define this or obsolete it and move children somewhere else. is_a: PATO:0000001 ! quality [Term] id: PATO:0000069 name: deviation (from_normal) namespace: quality def: "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000070 name: amount namespace: quality alt_id: PATO:0000053 alt_id: PATO:0000071 alt_id: PATO:0001169 alt_id: PATO:0001226 def: "The number of entities of this type that are part of the whole organism." [PATOC:GVG] comment: This term was originally named "presence". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10. subset: attribute_slim synonym: "count in organism" RELATED [] synonym: "number" RELATED [] synonym: "presence" RELATED [] synonym: "presence or absence in organism" EXACT [] synonym: "quantitative" EXACT [] is_a: PATO:0000068 ! qualitative relationship: RO:0015012 PATO:0001555 ! reciprocal of has number of [Term] id: PATO:0000085 name: sensitivity toward namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation." [PATOC:GVG] subset: attribute_slim subset: disposition_slim subset: relational_slim synonym: "sensitivity" EXACT [] is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000117 name: size namespace: quality def: "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." [WordNet:WordNet] subset: attribute_slim subset: scalar_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000122 name: length namespace: quality def: "A 1-D extent quality which is equal to the distance between two points." [PATOC:GVG] comment: Length often refers to the longer or longest dimension of an object, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion. subset: attribute_slim subset: mpath_slim subset: scalar_slim is_a: PATO:0001708 ! 1-D extent property_value: seeAlso "https://github.com/pato-ontology/pato/issues/337" xsd:string [Term] id: PATO:0000161 name: rate namespace: quality def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time." [PATOC:melissa] subset: attribute_slim subset: scalar_slim is_a: PATO:0002062 ! physical quality of a process [Term] id: PATO:0000169 name: viability namespace: quality def: "An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000297 name: arrested namespace: quality alt_id: PATO:0001508 def: "A quality of a process which ends earlier than the natural end time or reference process." [PATOC:LC] comment: TODO: the definition is incorrect. See absent. subset: value_slim synonym: "abolished" EXACT [] synonym: "incomplete" RELATED [] is_a: PATO:0002052 ! decreased occurrence is_a: PATO:0002324 ! offset quality [Term] id: PATO:0000460 name: abnormal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "aberrant" RELATED [] synonym: "atypia" RELATED [] synonym: "atypical" RELATED [] synonym: "defective" RELATED [] is_a: PATO:0000069 ! deviation (from_normal) property_value: RO:0002604 PATO:0000461 [Term] id: PATO:0000461 name: normal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "average" RELATED [] is_a: PATO:0000068 ! qualitative property_value: RO:0002604 PATO:0000460 [Term] id: PATO:0000462 name: absent namespace: quality alt_id: PATO:0001996 def: "A quality denoting the lack of an entity." [thefreedictionary.:thefreedictionary.] comment: We recommend using the new absent terms (physical absence, absent anatomical entity, or absent process) instead of this class. This is a legacy term and will ultimately be obsoleted.\nSee https://github.com/pato-ontology/pato/issues/331. subset: absent_slim subset: mpath_slim subset: value_slim synonym: "absence" EXACT [] synonym: "absent from organism" EXACT [] is_a: PATO:0000070 ! amount disjoint_from: PATO:0000467 ! present relationship: RO:0015012 PATO:0001558 ! reciprocal of lacking processual parts relationship: RO:0015012 PATO:0002000 ! reciprocal of lacks all parts of type property_value: RO:0002604 PATO:0000467 [Term] id: PATO:0000467 name: present namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's existence." [PATOC:GVG] subset: absent_slim subset: value_slim synonym: "present in organism" RELATED [] is_a: PATO:0000070 ! amount property_value: RO:0002604 PATO:0000462 [Term] id: PATO:0000470 name: increased amount namespace: quality alt_id: PATO:0000420 alt_id: PATO:0000650 def: "An amount which is relatively high." [PATOC:GVG] subset: value_slim synonym: "accessory" RELATED [] synonym: "increased" RELATED [] synonym: "increased number" EXACT [] synonym: "present in greater numbers in organism" EXACT [] synonym: "supernumerary" EXACT [] is_a: PATO:0000467 ! present is_a: PATO:0002300 ! increased quality intersection_of: PATO:0000070 ! amount intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001997 [Term] id: PATO:0000498 name: increased duration namespace: quality alt_id: PATO:0000715 def: "A duration quality of a process which is relatively high." [PATOC:GVG] subset: value_slim synonym: "chronic" RELATED [] synonym: "high time" EXACT [] synonym: "increased period" EXACT [] synonym: "increased time" EXACT [] synonym: "prolonged period" RELATED [] synonym: "slow time" RELATED [] is_a: PATO:0001309 ! duration is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001309 ! duration intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000499 [Term] id: PATO:0000499 name: decreased duration namespace: quality alt_id: PATO:0000716 def: "A duration quality of a process which is relatively low." [PATOC:GVG] subset: value_slim synonym: "decreased period" EXACT [] synonym: "decreased time" EXACT [] synonym: "fast time" RELATED [] synonym: "low period" EXACT [] synonym: "shortened period" EXACT [] is_a: PATO:0001309 ! duration is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001309 ! duration intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000498 [Term] id: PATO:0000502 name: delayed namespace: quality def: "A quality of a process which starts later than the natural start time or the reference process." [PATOC:LC] subset: value_slim synonym: "late" RELATED [] is_a: PATO:0002325 ! onset quality [Term] id: PATO:0000516 name: sensitive toward namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having sensitivity toward an external stimulus." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "sensitive" EXACT [] is_a: PATO:0000085 ! sensitivity toward property_value: RO:0002604 PATO:0000513 [Term] id: PATO:0000573 name: increased length namespace: quality def: "A length quality which is relatively large." [PATOC:GVG] subset: value_slim synonym: "long" EXACT [] is_a: PATO:0000122 ! length is_a: PATO:0000586 ! increased size intersection_of: PATO:0000122 ! length intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000574 [Term] id: PATO:0000574 name: decreased length namespace: quality def: "A length quality which is relatively small." [PATOC:GVG] subset: value_slim synonym: "short" EXACT [] synonym: "shortened" RELATED [] synonym: "stubby" RELATED [] is_a: PATO:0000122 ! length is_a: PATO:0000587 ! decreased size intersection_of: PATO:0000122 ! length intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000573 [Term] id: PATO:0000586 name: increased size namespace: quality alt_id: PATO:0001202 def: "A size quality which is relatively high." [PATOC:GVG] subset: value_slim synonym: "big" RELATED [] synonym: "enlarged" RELATED [] synonym: "expanded" RELATED [] synonym: "great" RELATED [] synonym: "large" RELATED [] is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000587 [Term] id: PATO:0000587 name: decreased size namespace: quality def: "A size quality which is relatively low." [PATOC:GVG] subset: value_slim synonym: "hypoplasia" NARROW [] synonym: "reduced" RELATED [] synonym: "small" RELATED [] synonym: "tiny" RELATED [] synonym: "underdeveloped" NARROW [] is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000586 [Term] id: PATO:0000694 name: premature namespace: quality alt_id: PATO:0000691 alt_id: PATO:0002086 def: "A quality of a process which starts earlier than the natural start time or the reference process." [PATO:LC] subset: value_slim synonym: "advanced" EXACT [] synonym: "early" RELATED [] synonym: "precocious" RELATED [] is_a: PATO:0002325 ! onset quality [Term] id: PATO:0000718 name: lethal (sensu genetics) namespace: quality def: "A viability quality inhering in a population by virtue of the bearer's long term survival inability." [PATOC:GVG] subset: disposition_slim subset: value_slim is_a: PATO:0000169 ! viability [Term] id: PATO:0000911 name: decreased rate namespace: quality def: "A rate which is relatively low." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "slow rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000161 ! rate intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000912 [Term] id: PATO:0000912 name: increased rate namespace: quality def: "A rate which is relatively high." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "fast rate" EXACT [] synonym: "high rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000161 ! rate intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000911 [Term] id: PATO:0001046 name: resistance to namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's disposition to resist to a stimulus." [PATOC:GVG] subset: attribute_slim subset: disposition_slim subset: relational_slim subset: scalar_slim synonym: "resistance" EXACT [] is_a: PATO:0001995 ! organismal quality property_value: RO:0002604 PATO:0001043 [Term] id: PATO:0001159 name: concentrated namespace: quality def: "A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0000033 ! concentration of [Term] id: PATO:0001162 name: increased concentration namespace: quality def: "A concentration which is higher relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "high concentration" EXACT [] is_a: PATO:0001159 ! concentrated is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001163 [Term] id: PATO:0001163 name: decreased concentration namespace: quality def: "A concentration which is lower relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "low concentration" EXACT [] is_a: PATO:0001159 ! concentrated is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001162 [Term] id: PATO:0001178 name: resistant to namespace: quality def: "A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "resistant" EXACT [] is_a: PATO:0001046 ! resistance to [Term] id: PATO:0001236 name: process quality namespace: quality alt_id: PATO:0001239 alt_id: PATO:0001240 def: "A quality which inheres in an process." [PATOC:GVG] comment: See comments of relational quality of a physical entity. synonym: "quality of a process" EXACT [] synonym: "quality of occurrent" EXACT [] synonym: "quality of process" EXACT [] synonym: "relational quality of occurrent" EXACT [] is_a: PATO:0000001 ! quality disjoint_from: PATO:0001241 ! physical object quality [Term] id: PATO:0001241 name: physical object quality namespace: quality alt_id: PATO:0001237 alt_id: PATO:0001238 def: "A quality which inheres in a continuant." [PATOC:GVG] comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. synonym: "monadic quality of a continuant" EXACT [] synonym: "monadic quality of an object" NARROW [] synonym: "monadic quality of continuant" NARROW [] synonym: "multiply inhering quality of a physical entity" EXACT [] synonym: "quality of a continuant" EXACT [] synonym: "quality of a single physical entity" EXACT [] synonym: "quality of an object" EXACT [] synonym: "quality of continuant" EXACT [] xref: snap:Quality is_a: PATO:0000001 ! quality [Term] id: PATO:0001309 name: duration namespace: quality alt_id: PATO:0000081 def: "A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point." [PATOC:mellybelly] subset: attribute_slim subset: hpo_slim synonym: "period" EXACT [] synonym: "time" RELATED [] is_a: PATO:0002062 ! physical quality of a process [Term] id: PATO:0001396 name: cellular quality namespace: quality def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG] is_a: PATO:0070044 ! anatomical structure quality [Term] id: PATO:0001404 name: nucleate quality namespace: quality def: "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001405 name: anucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0001406 name: binucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001908 ! multinucleate [Term] id: PATO:0001407 name: mononucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001457 name: sensitivity of a process namespace: quality def: "A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation." [PATOC:GVG] subset: attribute_slim subset: disposition_slim subset: relational_slim synonym: "sensitivity of occurrent" EXACT [] is_a: PATO:0002062 ! physical quality of a process [Term] id: PATO:0001549 name: increased sensitivity toward namespace: quality def: "A sensitivity toward an external stimulus which is higher than normal/average." [PATO:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "high sensitivity toward" EXACT [] synonym: "increased sensitivity" EXACT [] is_a: PATO:0000516 ! sensitive toward is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000516 ! sensitive toward intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001550 [Term] id: PATO:0001550 name: decreased sensitivity toward namespace: quality def: "A sensitivity toward an external stimulus which is lower than normal/average." [PATO:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "decreased sensitivity" EXACT [] synonym: "low sensitivity toward" EXACT [] is_a: PATO:0000516 ! sensitive toward is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000516 ! sensitive toward intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001549 [Term] id: PATO:0001551 name: increased sensitivity of a process namespace: quality def: "A sensitivity of a process which is higher than normal or average." [PATO:GVG] subset: relational_slim subset: value_slim synonym: "high sensitivity of occurrent" EXACT [] synonym: "increased sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001552 [Term] id: PATO:0001552 name: decreased sensitivity of a process namespace: quality def: "A sensitivity of a process which is lower than normal or average." [PATO:GVG] subset: relational_slim subset: value_slim synonym: "decreased sensitivity of occurrent" EXACT [] synonym: "low sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001551 [Term] id: PATO:0001555 name: has number of namespace: quality def: "The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts." [PATOC:CJM] subset: attribute_slim subset: relational_slim synonym: "cardinality" RELATED [] synonym: "extra or missing physical or functional parts" EXACT [] synonym: "has or lacks parts of type" EXACT [] synonym: "mereological quality" EXACT [] synonym: "number" RELATED [] synonym: "number of" EXACT [] xref: OBO_REL:has_part is_a: PATO:0001241 ! physical object quality relationship: RO:0015012 PATO:0000070 ! reciprocal of amount [Term] id: PATO:0001558 name: lacking processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0001564 ! extra or missing processual parts relationship: RO:0015012 PATO:0000462 ! reciprocal of absent [Term] id: PATO:0001564 name: extra or missing processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's processual parts." [PATOC:GVG] subset: relational_slim is_a: PATO:0001236 ! process quality [Term] id: PATO:0001650 name: increased resistance to namespace: quality def: "A resistance to a stimulus which is relatively high." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "high resistance to" EXACT [] synonym: "increased resistance" EXACT [] is_a: PATO:0001178 ! resistant to is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001178 ! resistant to intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001651 [Term] id: PATO:0001651 name: decreased resistance to namespace: quality def: "A resistance to a stimulus which is relatively low." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "decreased resistance" EXACT [] synonym: "low resistance to" EXACT [] is_a: PATO:0001178 ! resistant to is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001178 ! resistant to intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001650 [Term] id: PATO:0001708 name: 1-D extent namespace: quality def: "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." [PATOC:GVG] subset: attribute_slim synonym: "1-D size" EXACT [] is_a: PATO:0000117 ! size [Term] id: PATO:0001905 name: has normal numbers of parts of type namespace: quality def: "The bearer of this quality has_part = n, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." [PATOC:CJM] subset: relational_slim synonym: "having physical part" EXACT [] is_a: PATO:0001555 ! has number of relationship: RO:0015012 PATO:0002050 ! reciprocal of normal amount [Term] id: PATO:0001908 name: multinucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001995 name: organismal quality namespace: quality def: "A quality that inheres in an entire organism or part of an organism." [PATOC:CJM] is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001997 name: decreased amount namespace: quality alt_id: PATO:0000419 alt_id: PATO:0000468 def: "An amount which is relatively low." [PATOC:GVG] subset: value_slim synonym: "decreased" RELATED [] synonym: "decreased number" EXACT [] synonym: "present in fewer numbers in organism" EXACT [] synonym: "reduced" RELATED [] synonym: "subnumerary" RELATED [] is_a: PATO:0000467 ! present is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0000070 ! amount intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000470 [Term] id: PATO:0001999 name: lacks parts or has fewer parts of type namespace: quality def: "The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type." [PATOC:CJM] subset: relational_slim synonym: "loss of" EXACT [] is_a: PATO:0002083 ! altered number of [Term] id: PATO:0002000 name: lacks all parts of type namespace: quality alt_id: PATO:0001557 def: "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity." [PATOC:CJM] comment: Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2. subset: relational_slim synonym: "lacks all physical parts of type" EXACT [] xref: OBO_REL:lacks_part is_a: PATO:0001999 ! lacks parts or has fewer parts of type relationship: RO:0015012 PATO:0000462 ! reciprocal of absent [Term] id: PATO:0002001 name: has fewer parts of type namespace: quality alt_id: PATO:0001569 def: "The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly." [PATOC:CJM] comment: Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type. subset: relational_slim synonym: "decreased number of" EXACT [] synonym: "has decreased number of" EXACT [] synonym: "has fewer physical parts of type" EXACT [] is_a: PATO:0001999 ! lacks parts or has fewer parts of type is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001999 ! lacks parts or has fewer parts of type intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0002002 [Term] id: PATO:0002002 name: has extra parts of type namespace: quality alt_id: PATO:0001560 def: "The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." [PATOC:CJM] comment: In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q= E2=finger. subset: relational_slim synonym: "has extra parts of" EXACT [] synonym: "has increased number of" EXACT [] synonym: "having extra physical parts" EXACT [] synonym: "having supernumerary physical parts" EXACT [] synonym: "increased number of" EXACT [] is_a: PATO:0002083 ! altered number of is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002083 ! altered number of intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0002001 [Term] id: PATO:0002050 name: normal amount namespace: quality def: "An amount which normal." [PATOC:GVG] synonym: "present in normal numbers in organism" EXACT [] is_a: PATO:0000467 ! present relationship: RO:0015012 PATO:0001905 ! reciprocal of has normal numbers of parts of type property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-03-20T11:16:22Z [Term] id: PATO:0002051 name: increased occurrence namespace: quality def: "An occurrence which is relatively high." [PATOC:GVG] synonym: "increased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002052 creation_date: 2009-03-26T11:10:11Z [Term] id: PATO:0002052 name: decreased occurrence namespace: quality def: "An occurrence which is relatively low." [PATOC:GVG] synonym: "decreased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002051 creation_date: 2009-03-26T11:12:35Z [Term] id: PATO:0002062 name: physical quality of a process namespace: quality subset: attribute_slim is_a: PATO:0001236 ! process quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-06-05T09:16:46Z [Term] id: PATO:0002083 name: altered number of namespace: quality def: "Having extra or fewer parts." [PATOC:GVG] subset: attribute_slim subset: relational_slim is_a: PATO:0000051 ! morphology is_a: PATO:0001555 ! has number of property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-09-21T10:41:58Z [Term] id: PATO:0002146 name: virulence namespace: quality def: "A quality inhering in a bearer by virtue of the severity of infectious disease caused by the bearer in a target organism." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0001-8941-3984] subset: attribute_slim subset: scalar_slim is_a: PATO:0001995 ! organismal quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-30T05:04:06Z [Term] id: PATO:0002147 name: reduced virulence namespace: quality def: "A virulence that is relatively low." [PATOC:GVG] subset: value_slim synonym: "attenuated" EXACT [] is_a: PATO:0002146 ! virulence is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0002146 ! virulence intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002148 creation_date: 2009-10-30T05:05:02Z [Term] id: PATO:0002148 name: increased virulence namespace: quality def: "A virulence that is relatively high." [PATOC:GVG] subset: value_slim is_a: PATO:0002146 ! virulence is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002146 ! virulence intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002147 creation_date: 2009-10-30T05:13:10Z [Term] id: PATO:0002182 name: molecular quality namespace: quality alt_id: PATO:0002061 def: "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." [PATOC:GVG] synonym: "relational molecular quality" EXACT [] is_a: PATO:0001241 ! physical object quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-03-10T03:18:15Z [Term] id: PATO:0002300 name: increased quality namespace: quality def: "A quality that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal relationship: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002301 creation_date: 2011-06-16T06:39:43Z [Term] id: PATO:0002301 name: decreased quality namespace: quality def: "A quality that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal relationship: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002300 creation_date: 2011-06-16T06:40:15Z [Term] id: PATO:0002302 name: decreased process quality namespace: quality def: "A quality of a process that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002304 creation_date: 2011-06-16T06:50:59Z [Term] id: PATO:0002303 name: decreased object quality namespace: quality def: "A quality of an object that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002305 creation_date: 2011-06-16T06:51:54Z [Term] id: PATO:0002304 name: increased process quality namespace: quality def: "A quality of a process that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002302 creation_date: 2011-06-16T06:53:08Z [Term] id: PATO:0002305 name: increased object quality namespace: quality def: "A quality of an object that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002303 creation_date: 2011-06-16T06:54:01Z [Term] id: PATO:0002323 name: temporal distribution quality namespace: quality def: "A temporal distribution pattern of process occurrences within a regulation/reference process." [PATOC:LC] subset: attribute_slim is_a: PATO:0002062 ! physical quality of a process property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-11-22T01:12:28Z [Term] id: PATO:0002324 name: offset quality namespace: quality def: "The temporal relation between the end of the process with respect to a reference process." [PATOC:LC] subset: attribute_slim synonym: "completeness" RELATED [GOC:CJM] synonym: "extent" RELATED [GOC:CJM] is_a: PATO:0002323 ! temporal distribution quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-11-23T11:46:00Z [Term] id: PATO:0002325 name: onset quality namespace: quality def: "The temporal relation between the start of the process with respect to a reference process." [PATOC:LC] subset: attribute_slim synonym: "initiation" RELATED [] is_a: PATO:0002323 ! temporal distribution quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-11-23T11:47:34Z [Term] id: PATO:0002505 name: nucleated namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-10-21T05:44:34Z [Term] id: PATO:0040003 name: pathogenicity namespace: quality def: "The ability of a pathogen to produce an infectious disease or disorder in an another organism." [https://orcid.org/0000-0001-8941-3984] is_a: PATO:0001995 ! organismal quality property_value: http://purl.org/dc/elements/1.1/date "2018-08-02T04:24:52Z" xsd:dateTime property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-5208-3432 [Term] id: PATO:0045000 name: normal rate namespace: quality def: "A rate which is relatively normal." [] subset: mpath_slim subset: value_slim is_a: PATO:0000161 ! rate is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0000161 ! rate intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0045001 name: normal object quality namespace: quality def: "A quality of an object that has a value that is normal or average." [] is_a: PATO:0001241 ! physical object quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal relationship: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-21T14:11:01Z [Term] id: PATO:0045010 name: normal concentration namespace: quality def: "A concentration which is relatively normal or average." [] subset: relational_slim subset: value_slim is_a: PATO:0001159 ! concentrated is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0001159 ! concentrated intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045047 name: normal resistance to namespace: quality def: "A resistance to a stimulus which is relatively normal or average" [] subset: disposition_slim subset: relational_slim subset: value_slim is_a: PATO:0001178 ! resistant to is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0001178 ! resistant to intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045049 name: normal sensitivity toward namespace: quality def: "A sensitivity toward an external stimulus which is relatively normal or average" [] subset: disposition_slim subset: relational_slim subset: value_slim is_a: PATO:0000516 ! sensitive toward is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000516 ! sensitive toward intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045050 name: normal size namespace: quality def: "A size quality which is relatively normal or average" [] subset: value_slim is_a: PATO:0000117 ! size is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045054 name: normal length namespace: quality def: "A length quality which is relatively normal or average" [] subset: value_slim is_a: PATO:0000122 ! length is_a: PATO:0045050 ! normal size intersection_of: PATO:0000122 ! length intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045073 name: normal process quality namespace: quality def: "A quality of a process that has a value that is normal or average." [] is_a: PATO:0001236 ! process quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal relationship: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-21T14:11:01Z [Term] id: PATO:0045080 name: normal virulence namespace: quality def: "A virulence which is relatively normal or average" [] subset: value_slim is_a: PATO:0002146 ! virulence is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0002146 ! virulence intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-9227-0670 creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045084 name: normal duration namespace: quality def: "A duration quality of a process which is relatively normal." [] subset: value_slim is_a: PATO:0001309 ! duration is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0001309 ! duration intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0045086 name: normal occurrence namespace: quality def: "An occurrence which is relatively normal." [] subset: value_slim is_a: PATO:0000057 ! occurrence is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0045088 name: normal sensitivity of a process namespace: quality def: "A sensitivity of a process which is relatively normal." [] subset: relational_slim subset: value_slim is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0070044 name: anatomical structure quality namespace: quality def: "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." [] is_a: PATO:0001241 ! physical object quality created_by: http://orcid.org/0000-0001-7258-9596 [Term] id: PHIPO:0000001 name: pathogen host interaction phenotype namespace: pathogen_host_interaction_phenotype def: "Any of the set of observable characteristics arising from the interaction of a potentially pathogenic organism with a host organism." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000505 ! phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-02T11:20:17Z" xsd:string [Term] id: PHIPO:0000002 name: single species phenotype namespace: single_species_phenotype def: "Any of the set of observable characteristics of a single organism resulting from the interaction of its genotype with the environment." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000505 ! phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-02T11:20:59Z" xsd:string [Term] id: PHIPO:0000003 name: tissue phenotype namespace: single_species_phenotype def: "A single organism phenotype that is observed at the level of a tissue (eg leaf, inflorescence, ear or kidney)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000402 ! individual organism phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-02T11:21:13Z" xsd:string [Term] id: PHIPO:0000004 name: unaffected pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen, to produce an infectious disease in another organism is unaffected (i.e the same as wild-type, it could be pathogenic or non-pathogenic)." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. subset: qc_extension_only synonym: "normal pathogenicity" EXACT [] synonym: "unaffected disease causing ability" EXACT [] synonym: "unaltered pathogenicity" EXACT [] synonym: "unchanged pathogenicity" EXACT [] is_a: PHIPO:0000006 ! pathogenicity phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T12:38:43Z" xsd:string [Term] id: PHIPO:0000005 name: obsolete abnormal pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the pathogenicity is abnormal (i.e different than wild-type)" [] property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T12:39:00Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000006 name: pathogenicity phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype that is relevant to pathogenicity. Pathogenicity is the ability of an organism, a pathogen, to produce an infectious disease in another organism" [] comment: Can only apply to changes in the pathogen. Pathogenicity is a qualitative concept. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "disease causing ability" EXACT [] synonym: "pathogenesis (related)" RELATED [] is_a: PHIPO:0001179 ! infective ability phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T12:39:55Z" xsd:string [Term] id: PHIPO:0000007 name: obsolete functional pathogen effector absent namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen effector to produce an infectious disease is absent." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. subset: qc_do_not_annotate synonym: "disease causing ability absent" EXACT [] synonym: "pathogenic ability absent" BROAD [] property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T12:42:00Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000008 name: obsolete functional pathogen effector present namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen effector to produce an infectious disease is present." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. subset: qc_do_not_annotate synonym: "disease causing ability present" EXACT [] synonym: "pathogenic ability present" BROAD [] property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T12:42:16Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000009 name: gain of pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen, to produce an infectious disease in another organism is obtained (pathogenicity was absent and is now present)." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. Note that this ability to cause pathogenicity is a feature of the pathogen. Therefore gain/loss of pathogenicity should never be dependent on changes to the host genotype, only on changes to the pathogen genotype. If you are annotating changes in disease presence or absence dependent on the changes to the host consider increased/decreased virulence phenotypes. subset: qc_extension_only synonym: "gain of disease causing ability" EXACT [] is_a: PHIPO:0000006 ! pathogenicity phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T12:45:12Z" xsd:string [Term] id: PHIPO:0000010 name: loss of pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen, to produce an infectious disease in another organism is abolished (pathogenicity was present and is now absent)." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. Note that this ability to cause pathogenicity is a feature of the pathogen. Therefore gain/loss of pathogenicity should never be dependent on changes to the host genotype, only on changes to the pathogen genotype. If you are annotating changes in disease presence or absence dependent on the changes to the host consider increased/decreased virulence phenotypes. Note that avirulence means loss of/abolished virulence in plant pathology terminology. subset: qc_extension_only synonym: "abolished pathogenicity" EXACT [] synonym: "loss of disease causing ability" EXACT [] is_a: PHIPO:0000006 ! pathogenicity phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T12:45:31Z" xsd:string [Term] id: PHIPO:0000011 name: virulence phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype that is relevant to virulence. Virulence is the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism. (Virulence is observed where pathogenicity is present)." [] comment: Can apply to changes in the pathogen or the host. Virulence is a quantitative concept subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "disease severity" EXACT [] is_a: PHIPO:0001179 ! infective ability phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:02:03Z" xsd:string [Term] id: PHIPO:0000012 name: unaffected virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is unchanged (i.e. the same degree of infectious disease as wild-type interaction)." [] comment: For use in the annotation extension infective ability. Can apply to changes in the pathogen or the host. subset: qc_do_not_annotate synonym: "normal virulence" EXACT [] synonym: "unaffected disease severity" EXACT [] is_a: PHIPO:0000011 ! virulence phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:02:23Z" xsd:string [Term] id: PHIPO:0000013 name: obsolete abnormal virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where virulence is abnormal (i.e. different than wild-type)." [] property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:02:39Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000014 name: increased virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is increased (i.e. more symptoms than normal)." [] comment: For use in the annotation extension infective ability. Can apply to changes in the pathogen or the host. subset: qc_extension_only synonym: "hypervirulence" EXACT [] synonym: "increased disease severity" EXACT [] is_a: PHIPO:0000011 ! virulence phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:07:31Z" xsd:string [Term] id: PHIPO:0000015 name: reduced virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is decreased (i.e. fewer symptoms than normal)." [] comment: For use in the annotation extension infective ability. Can apply to changes in the pathogen or the host. subset: qc_extension_only synonym: "decreased virulence" EXACT [] synonym: "reduced disease severity" EXACT [] is_a: PHIPO:0000011 ! virulence phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:08:10Z" xsd:string [Term] id: PHIPO:0000016 name: normal single species phenotype namespace: single_species_phenotype def: "A single organism phenotype which is normal (i.e. the same as wild-type)." [] is_a: PHIPO:0000002 ! single species phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:10:48Z" xsd:string [Term] id: PHIPO:0000017 name: abnormal single species phenotype namespace: single_species_phenotype def: "A single organism phenotype which is abnormal (i.e. different than wild-type)." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:11:04Z" xsd:string [Term] id: PHIPO:0000018 name: lipid droplets present in decreased numbers namespace: single_species_phenotype def: "A single species phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer lipid droplets than normal." [] xref: FYPO:0002552 is_a: PHIPO:0000474 ! abnormal number of lipid droplets property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:12:20Z" xsd:string [Term] id: PHIPO:0000019 name: inviable cell namespace: single_species_phenotype def: "A lethal single organism cell level phenotype resulting from altering a gene product that is essential for the life of the organism." [] synonym: "essential" RELATED [] synonym: "lethal" RELATED [] is_a: PHIPO:0001222 ! cell viability phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:12:47Z" xsd:string [Term] id: PHIPO:0000021 name: increased sensitivity to chemical namespace: single_species_phenotype alt_id: PHIPO:0000020 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to a specific chemical. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] synonym: "decreased resistance to chemical" EXACT [] synonym: "increased sensitivity to chemical during growth" RELATED [] is_a: PHIPO:0001218 ! chemical phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:15:05Z" xsd:string [Term] id: PHIPO:0000022 name: increased resistance to chemical namespace: single_species_phenotype alt_id: PHIPO:0000412 def: "A growth phenotype which describes the resistance of individuals or populations after exposure to a specific chemical. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] synonym: "increased resistance to chemical during growth" RELATED [] is_a: PHIPO:0001218 ! chemical phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:16:06Z" xsd:string [Term] id: PHIPO:0000023 name: obsolete abnormal penetration assay phenotype namespace: single_species_phenotype def: "A pathogen penetration assay phenotype (assessing the organism's ability to penetrate a given substance/membrane) which is abnormal (i.e. different than wild-type)." [] subset: pathogen_phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:16:54Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000024 name: pathogen penetration across the barrier present namespace: single_species_phenotype def: "A single species pathogen penetration phenotype in which pathogen penetration of a given experimental substance/membrane is present." [] subset: pathogen_phenotype is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:17:08Z" xsd:string [Term] id: PHIPO:0000025 name: obsolete normal mating phenotype prior to penetration namespace: single_species_phenotype comment: Is this a bit too specific? should this be with sexual reproduction? eg ustilago and rust fungus MU agrees REMOVE from penetration property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:17:46Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000026 name: obsolete normal penetration namespace: single_species_phenotype def: "A pathogen phenotype indicating that the pathogen is able to penetrate a given experimental substance/membrane in the same manner as the wild-type." [] subset: pathogen_phenotype synonym: "no penetration defect" EXACT [] property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:18:03Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000027 name: normal pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the pathogen's ability to contine to grow after penetration of a given experimental substance/membrane in an in vitro assay is normal (i.e indistinguishable from wild type)." [] subset: pathogen_phenotype synonym: "normal pathogen post penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:19:13Z" xsd:string [Term] id: PHIPO:0000028 name: normal formation of pathogen penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the formation of the pathogen penetration structure is normal (i.e same as wild-type) when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "normal formation of pathogen infection structure" EXACT [] synonym: "normal pathogen pre penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:19:44Z" xsd:string [Term] id: PHIPO:0000029 name: obsolete abnormal mating phenotype prior to penetration namespace: single_species_phenotype comment: Is this a bit too specific? should this be with reproduction? property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:22:14Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000030 name: pathogen penetration across the barrier absent namespace: single_species_phenotype def: "A single species pathogen penetration phenotype in which pathogen penetration of a given experimental substance/membrane is absent." [] subset: pathogen_phenotype synonym: "penetration defect" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:22:31Z" xsd:string [Term] id: PHIPO:0000031 name: abnormal pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the pathogen's ability to contine to grow after penetration of a given experimental substance/membrane in an in vitro assay is abnormal (i.e indistinguishable from wild type)." [] subset: pathogen_phenotype synonym: "abnormal pathogen post penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:22:52Z" xsd:string [Term] id: PHIPO:0000032 name: abnormal formation of pathogen penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the formation of the pathogen penetration structure is abnormal (i.e different than wild-type) when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "abnormal formation of pathogen infection structure" EXACT [] synonym: "abnormal pathogen pre penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-05-04T13:23:06Z" xsd:string [Term] id: PHIPO:0000033 name: obsolete abnormal pathogen growth on host surface namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype where the vegetative growth or proliferation of the pathogen on the host surface is abnormal." [] property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-07-04T13:41:02Z" xsd:string is_obsolete: true [Term] id: PHIPO:0000034 name: cell phenotype namespace: single_species_phenotype def: "A single species phenotype that is observed at the level of an individual cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000002 is_a: PHIPO:0000402 ! individual organism phenotype property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-07-04T13:41:14Z" xsd:string [Term] id: PHIPO:0000035 name: mutualism present namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype where the mutualism phenotype is normal (i.e. the same as wild-type), and the wild-type interaction exhibits mutualism." [] subset: qc_extension_only is_a: PHIPO:0000039 ! normal mutualism property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-07-09T13:41:47Z" xsd:string [Term] id: PHIPO:0000036 name: abnormal lipid droplet morphology namespace: single_species_phenotype def: "A single organism phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of lipid droplets is abnormal." [] xref: FYPO:0000356 is_a: PHIPO:0000478 ! lipid droplet phenotype created_by: alaynecuzick creation_date: 2019-01-14T12:21:13Z [Term] id: PHIPO:0000038 name: mutualism phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype which affects the balance of symbiotic mutualism, mutualism describes an interaction between two symbionts (where the larger is usually the host), results in positive (beneficial) effects on reproduction and/or survival of both species." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0001179 ! infective ability phenotype created_by: alaynecuzick creation_date: 2018-07-10T11:52:04Z [Term] id: PHIPO:0000039 name: normal mutualism namespace: pathogen_host_interaction_phenotype def: "A phenotype in which the interaction is the same as the wild-type, no asymptomatic colonisation or disease formation symptoms are visible." [] comment: Logical definition mutualism (GO:0085030) and (has_relative_magnitude some normal (PATO:0000461)) subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000038 ! mutualism phenotype created_by: alaynecuzick creation_date: 2018-07-10T11:52:33Z [Term] id: PHIPO:0000040 name: abnormal mutualism namespace: pathogen_host_interaction_phenotype def: "A phenotype in which the balance of symbiotic mutualism has been disrupted compared to the normal interaction." [] comment: Logical definition mutualism (GO:0085030) and (has_relative_magnitude some abnormal (PATO:0000460)) need to choose correct language for term name subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000038 ! mutualism phenotype created_by: alaynecuzick creation_date: 2018-07-10T11:53:05Z [Term] id: PHIPO:0000041 name: obsolete normal motility phenotype namespace: single_species_phenotype comment: bacteria flagella aphid flight nematode wiggle fungi non-motile (apart from spores) also hosts is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T11:54:28Z [Term] id: PHIPO:0000042 name: obsolete abnormal motility phenotype namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T11:54:54Z [Term] id: PHIPO:0000043 name: abnormal reproduction phenotype namespace: single_species_phenotype def: "A single species phenotype where reproduction is abnormal." [] is_a: PHIPO:0000161 ! reproductive phenotype created_by: alaynecuzick creation_date: 2018-07-13T11:57:47Z [Term] id: PHIPO:0000044 name: normal reproduction phenotype namespace: single_species_phenotype def: "A single species phenotype where reproduction is normal (indistinguishable from wild type)." [] is_a: PHIPO:0000161 ! reproductive phenotype created_by: alaynecuzick creation_date: 2018-07-13T11:58:15Z [Term] id: PHIPO:0000045 name: normal asexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the asexual reproduction process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process is normal (indistinguishable from wild type)(GO:0019954)." [] synonym: "normal parthenogenesis" RELATED [] is_a: PHIPO:0000044 ! normal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:08:15Z [Term] id: PHIPO:0000046 name: normal sexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the sexual reproduction process in which new individuals are produced by combining the genetic material of two gametes, which may come from two organisms or from a single organism is normal (indistinguishable from wild type) (GO:0019953)." [] is_a: PHIPO:0000044 ! normal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:09:04Z [Term] id: PHIPO:0000047 name: abnormal asexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the asexual reproduction process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process is abnormal (GO:0019954)." [] synonym: "abnormal parthenogenesis" RELATED [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:09:49Z [Term] id: PHIPO:0000048 name: abnormal sexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the sexual reproduction process in which new individuals are produced by combining the genetic material of two gametes, which may come from two organisms or from a single organism is abnormal (GO:0019953)." [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:10:14Z [Term] id: PHIPO:0000049 name: increased number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is increased." [] is_a: PHIPO:0000073 ! abnormal number of sexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:16:49Z [Term] id: PHIPO:0000050 name: decreased number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is decreased." [] is_a: PHIPO:0000073 ! abnormal number of sexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:17:15Z [Term] id: PHIPO:0000051 name: increased number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is increased." [] synonym: "increased number of conidia" EXACT [] is_a: PHIPO:0000082 ! abnormal number of asexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:18:08Z [Term] id: PHIPO:0000052 name: decreased number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is decreased." [] synonym: "decreased number of conidia" EXACT [] synonym: "fewer conidia" EXACT [] is_a: PHIPO:0000082 ! abnormal number of asexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:18:34Z [Term] id: PHIPO:0000053 name: delayed asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of asexual spore formation happens later than normal." [] is_a: PHIPO:0000078 ! abnormal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:20:33Z [Term] id: PHIPO:0000054 name: premature asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of asexual spore formation happens sooner than normal." [] is_a: PHIPO:0000078 ! abnormal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:22:31Z [Term] id: PHIPO:0000055 name: delayed sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of sexual spore formation happens later than normal." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:23:43Z [Term] id: PHIPO:0000056 name: premature sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of sexual spore formation happens sooner than normal." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:24:07Z [Term] id: PHIPO:0000057 name: normal number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0000079 ! normal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:25:33Z [Term] id: PHIPO:0000058 name: obsolete normal timing in production of sexual spores namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:26:14Z [Term] id: PHIPO:0000059 name: normal number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is normal (i.e. indistinguishable from wild type)." [] synonym: "normal number of conidia" EXACT [] is_a: PHIPO:0000080 ! normal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:27:14Z [Term] id: PHIPO:0000060 name: obsolete normal timing in production of asexual spores namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:27:45Z [Term] id: PHIPO:0000061 name: asexual spores absent namespace: single_species_phenotype def: "A reproductive phenotype where asexual spores are absent (FAO:0000023)." [] synonym: "conidia absent" EXACT [] is_a: PHIPO:0000082 ! abnormal number of asexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:28:57Z [Term] id: PHIPO:0000062 name: sexual spores absent namespace: single_species_phenotype def: "A reproductive phenotype where sexual spores are absent (FAO:0000017)." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:29:31Z [Term] id: PHIPO:0000063 name: sexual spores present namespace: single_species_phenotype def: "A reproductive phenotype where asexual spores are present (FAO:0000017). The product of meiosis." [] is_a: PHIPO:0000079 ! normal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:29:58Z [Term] id: PHIPO:0000064 name: asexual spores present namespace: single_species_phenotype def: "A reproductive phenotype where asexual spores are present (FAO:0000023). The product of mitosis." [] synonym: "conidia present" EXACT [] is_a: PHIPO:0000080 ! normal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:30:18Z [Term] id: PHIPO:0000065 name: asexual spores increased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the asexual spore is increased." [] synonym: "conidia increased in size" EXACT [] is_a: PHIPO:0000081 ! abnormal asexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:32:36Z [Term] id: PHIPO:0000066 name: obsolete abnormal timing of asexual spore production namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:33:03Z [Term] id: PHIPO:0000067 name: asexual spores decreased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the asexual spore is decreased." [] synonym: "conidia decreased in size" EXACT [] is_a: PHIPO:0000081 ! abnormal asexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:36:00Z [Term] id: PHIPO:0000068 name: sexual spores increased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the sexual spore is increased." [] is_a: PHIPO:0000071 ! abnormal sexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:37:29Z [Term] id: PHIPO:0000069 name: sexual spores decreased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the sexual spore is decreased." [] is_a: PHIPO:0000071 ! abnormal sexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:37:52Z [Term] id: PHIPO:0000070 name: altered in pigment accumulation in sexual spore namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in a sexual spore cell is altered." [] is_a: PHIPO:0000285 ! abnormal cellular pigment accumulation created_by: alaynecuzick creation_date: 2018-07-13T12:38:19Z [Term] id: PHIPO:0000071 name: abnormal sexual spore size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the sexual spore is abnormal." [] is_a: PHIPO:0000130 ! abnormal sexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T12:39:04Z [Term] id: PHIPO:0000072 name: abnormal sexual spore shape namespace: single_species_phenotype def: "A reproductive morphology phenotype where the shape of the sexual spore is abnormal." [] is_a: PHIPO:0000130 ! abnormal sexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T12:39:34Z [Term] id: PHIPO:0000073 name: abnormal number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is abnormal." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:40:05Z [Term] id: PHIPO:0000074 name: obsolete abnormal timing of sexual spore production namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:42:05Z [Term] id: PHIPO:0000075 name: abnormal asexual spore shape namespace: single_species_phenotype def: "A reproductive morphology phenotype where the shape of the asexual spore is abnormal." [] synonym: "abnormal conidia shape" EXACT [] is_a: PHIPO:0000127 ! abnormal asexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T12:43:06Z [Term] id: PHIPO:0000076 name: altered in pigment accumulation in asexual spore namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in an asexual spore cell is altered." [] synonym: "altered in pigment accumulation in conidia" EXACT [] is_a: PHIPO:0000285 ! abnormal cellular pigment accumulation created_by: alaynecuzick creation_date: 2018-07-13T12:43:42Z [Term] id: PHIPO:0000077 name: abnormal sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of sexual sporulation, the formation of spores from the products of meiosis, is abnormal (GO:0034293)." [] synonym: "abnormal meiotic sporulation" EXACT [] synonym: "abnormal sexual spore formation" EXACT [] is_a: PHIPO:0000048 ! abnormal sexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:54:33Z [Term] id: PHIPO:0000078 name: abnormal asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of asexual sporulation, the formation of spores derived from the products of an asexual cell division, is abnormal (GO:0030436)." [] synonym: "abnormal asexual spore formation" EXACT [] synonym: "abnormal mitotic sporulation" EXACT [] is_a: PHIPO:0000047 ! abnormal asexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:55:38Z [Term] id: PHIPO:0000079 name: normal sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of sexual sporulation, the formation of spores from the products of meiosis, is normal (GO:0034293)." [] synonym: "normal meiotic sporulation" EXACT [] synonym: "normal sexual spore formation" EXACT [] is_a: PHIPO:0000046 ! normal sexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:56:11Z [Term] id: PHIPO:0000080 name: normal asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of asexual sporulation, the formation of spores derived from the products of an asexual cell division, is normal (GO:0030436)." [] synonym: "normal asexual spore formation" EXACT [] synonym: "normal mitotic sporulation" EXACT [] is_a: PHIPO:0000045 ! normal asexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:57:46Z [Term] id: PHIPO:0000081 name: abnormal asexual spore size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the asexual spore is abnormal." [] synonym: "abnormal conidia size" EXACT [] is_a: PHIPO:0000127 ! abnormal asexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T13:08:40Z [Term] id: PHIPO:0000082 name: abnormal number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is abnormal." [] synonym: "abnormal number of conidia" EXACT [] is_a: PHIPO:0000078 ! abnormal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T13:09:40Z [Term] id: PHIPO:0000083 name: obsolete abnormal asexual spore motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:17:24Z [Term] id: PHIPO:0000084 name: obsolete increased asexual spore motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:18:20Z [Term] id: PHIPO:0000085 name: obsolete decreased asexual spore motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:18:38Z [Term] id: PHIPO:0000086 name: obsolete normal asexual spore motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:21:21Z [Term] id: PHIPO:0000087 name: obsolete normal binary fission namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:25:48Z [Term] id: PHIPO:0000088 name: obsolete normal budding namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:27:00Z [Term] id: PHIPO:0000089 name: obsolete normal fragmentation namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:27:51Z [Term] id: PHIPO:0000090 name: obsolete normal parthenogenesis namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:28:15Z [Term] id: PHIPO:0000091 name: obsolete abnormal budding namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:30:12Z [Term] id: PHIPO:0000092 name: obsolete abnormal binary fission namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:30:30Z [Term] id: PHIPO:0000093 name: obsolete abnormal parthenogenesis namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:31:01Z [Term] id: PHIPO:0000094 name: obsolete normal mitosis in asexual reproduction namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:38:56Z [Term] id: PHIPO:0000095 name: obsolete abnormal mitosis in asexual reproduction namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T13:41:23Z [Term] id: PHIPO:0000096 name: abnormal meiosis II namespace: single_species_phenotype def: "A reproductive process phenotype in which the second meiotic nuclear division is abnormal (GO:0007135)." [] synonym: "abnormal second meiotic nuclear division" EXACT [] xref: FYPO:0006526 is_a: PHIPO:0000981 ! abnormal meiosis created_by: alaynecuzick creation_date: 2018-07-13T13:42:09Z [Term] id: PHIPO:0000097 name: abnormal meiosis I namespace: single_species_phenotype def: "A reproductive process phenotype in which the first meiotic nuclear division is abnormal (GO:0007127)." [] synonym: "abnormal first meiotic nuclear division" EXACT [] xref: FYPO:0003603 is_a: PHIPO:0000981 ! abnormal meiosis created_by: alaynecuzick [Term] id: PHIPO:0000098 name: normal meiosis II namespace: single_species_phenotype def: "A reproductive process phenotype in which the second meiotic nuclear division is normal (i.e. indistinguishable from wild type)(GO:0007135)." [] synonym: "normal second meiotic nuclear division" EXACT [] xref: FYPO:0003798 is_a: PHIPO:0000982 ! normal meiosis created_by: alaynecuzick creation_date: 2018-07-13T13:43:09Z [Term] id: PHIPO:0000099 name: normal meiosis I namespace: single_species_phenotype def: "A reproductive process phenotype in which the first meiotic nuclear division is normal (GO:0007127)." [] synonym: "normal first meiotic nuclear division" EXACT [] xref: FYPO:0003563 is_a: PHIPO:0000982 ! normal meiosis created_by: alaynecuzick creation_date: 2018-07-13T13:43:30Z [Term] id: PHIPO:0000100 name: obsolete increased motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T10:24:59Z [Term] id: PHIPO:0000101 name: obsolete decreased motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T10:25:07Z [Term] id: PHIPO:0000102 name: obsolete loss of motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T10:25:22Z [Term] id: PHIPO:0000103 name: obsolete gain of motility namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T10:25:33Z [Term] id: PHIPO:0000104 name: increased size of penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the size of pathogen penetration stuctures are increased when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "increased size of infection structure" EXACT [] is_a: PHIPO:0000032 ! abnormal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2018-07-17T10:58:56Z [Term] id: PHIPO:0000105 name: decreased size of penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the size of pathogen penetration stuctures are decreased when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "decreased size of infection structure" EXACT [] is_a: PHIPO:0000032 ! abnormal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2018-07-17T11:00:04Z [Term] id: PHIPO:0000106 name: increased number of penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the frequency of occurrence of pathogen penetration stuctures are increased when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "increased number of infection structure" EXACT [] is_a: PHIPO:0000032 ! abnormal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2018-07-17T11:00:54Z [Term] id: PHIPO:0000107 name: decreased number of penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the frequency of occurrence of pathogen penetration stuctures are decreased when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "decreased number of appressorium" EXACT [] synonym: "decreased number of infection structure" EXACT [] is_a: PHIPO:0000032 ! abnormal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2018-07-17T11:05:16Z [Term] id: PHIPO:0000108 name: delayed timing of penetration structure formation namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which formation of pathogen specialized penetration structure begins later than normal when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "delayed timing of infection structure formation" EXACT [] is_a: PHIPO:0000032 ! abnormal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2018-07-17T11:13:16Z [Term] id: PHIPO:0000109 name: premature penetration structure formation namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which formation of pathogen specialized penetration structure begins sooner than normal when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "premature infection structure formation" EXACT [] is_a: PHIPO:0000032 ! abnormal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2018-07-17T11:13:53Z [Term] id: PHIPO:0000110 name: abolished formation of pathogen penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the ability of the pathogen to form a specialized penetration structure is abolished when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "abolished formation of pathogen infection structure" EXACT [] is_a: PHIPO:0000032 ! abnormal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2018-07-17T11:16:18Z [Term] id: PHIPO:0000111 name: delayed pathogen penetration across the barrier namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the frequency of occurrence of pathogen penetration begins later than normal when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype is_a: PHIPO:0000024 ! pathogen penetration across the barrier present created_by: alaynecuzick creation_date: 2018-07-17T11:17:12Z [Term] id: PHIPO:0000112 name: obsolete non-functional penetration structure present namespace: single_species_phenotype subset: pathogen_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T11:19:23Z [Term] id: PHIPO:0000113 name: obsolete altered functionality of penetration structure namespace: single_species_phenotype def: "Penetration structure formed but not functioning in the same manner as the wild type." [] subset: pathogen_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T11:19:35Z [Term] id: PHIPO:0000114 name: increased pathogen penetration across the barrier namespace: single_species_phenotype def: "A single species pathogen penetration phenotype in which the frequency of occurrence of pathogen penetration of a given experimental substance/membrane is increased." [] subset: pathogen_phenotype is_a: PHIPO:0000024 ! pathogen penetration across the barrier present created_by: alaynecuzick creation_date: 2018-07-17T11:22:58Z [Term] id: PHIPO:0000115 name: decreased pathogen penetration across the barrier namespace: single_species_phenotype def: "A single species pathogen penetration phenotype in which the frequency of occurrence of pathogen penetration of a given experimental substance/membrane is decreased" [] subset: pathogen_phenotype is_a: PHIPO:0000024 ! pathogen penetration across the barrier present created_by: alaynecuzick creation_date: 2018-07-17T11:23:12Z [Term] id: PHIPO:0000116 name: abolished pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the pathogen's ability to contine to grow after penetration of a given experimental substance/membrane in an in vitro assay is abolished." [] subset: pathogen_phenotype is_a: PHIPO:0000031 ! abnormal pathogen growth after penetration of the barrier created_by: alaynecuzick creation_date: 2018-07-17T11:30:36Z [Term] id: PHIPO:0000117 name: increased pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the frequency of occurrence of pathogen growth after penetration of a given experimental substance/membrane in an in vitro assay is increased." [] subset: pathogen_phenotype is_a: PHIPO:0000031 ! abnormal pathogen growth after penetration of the barrier created_by: alaynecuzick creation_date: 2018-07-17T11:30:56Z [Term] id: PHIPO:0000118 name: decreased pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the frequency of occurrence of pathogen growth after penetration of a given experimental substance/membrane in an in vitro assay is decreased." [] subset: pathogen_phenotype is_a: PHIPO:0000031 ! abnormal pathogen growth after penetration of the barrier created_by: alaynecuzick creation_date: 2018-07-17T11:31:06Z [Term] id: PHIPO:0000119 name: delayed timing of pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the frequency of occurrence of pathogen growth after penetration of a given experimental substance/membrane in an in vitro assay begins later than normal." [] subset: pathogen_phenotype is_a: PHIPO:0000031 ! abnormal pathogen growth after penetration of the barrier created_by: alaynecuzick creation_date: 2018-07-17T11:31:15Z [Term] id: PHIPO:0000120 name: premature pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the frequency of occurrence of pathogen growth after penetration of a given experimental substance/membrane in an in vitro assay begins sooner than normal." [] subset: pathogen_phenotype is_a: PHIPO:0000031 ! abnormal pathogen growth after penetration of the barrier created_by: alaynecuzick creation_date: 2018-07-17T11:31:21Z [Term] id: PHIPO:0000121 name: abnormal asexual reproductive structure development namespace: single_species_phenotype def: "A single species phenotype where the asexual reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals, from their formation to the mature structures is abnormal (GO:0048608)." [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-17T11:44:01Z [Term] id: PHIPO:0000122 name: abnormal endospore formation namespace: single_species_phenotype def: "A reproductive phenotype where the process of endospore formation, in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell is abnormal. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions. (GO:0034301)" [] is_a: PHIPO:0000078 ! abnormal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-17T11:46:50Z [Term] id: PHIPO:0000124 name: obsolete abnormal penetration structure present namespace: single_species_phenotype subset: pathogen_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T12:23:31Z [Term] id: PHIPO:0000125 name: obsolete abnormal pathogen growth post penetration present namespace: single_species_phenotype subset: pathogen_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-17T12:28:43Z [Term] id: PHIPO:0000126 name: premature pathogen penetration across the barrier namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the frequency of occurrence of pathogen penetration begins sooner than normal when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype is_a: PHIPO:0000024 ! pathogen penetration across the barrier present created_by: alaynecuzick creation_date: 2018-07-17T12:39:33Z [Term] id: PHIPO:0000127 name: abnormal asexual spore morphology namespace: single_species_phenotype def: "A reproductive phenotype where the morphology of the asexual spore is abnormal (FAO:0000023). The product of mitosis." [] synonym: "abnormal conidia morphology" EXACT [] is_a: PHIPO:0000047 ! abnormal asexual reproduction created_by: alaynecuzick creation_date: 2018-07-17T13:01:41Z [Term] id: PHIPO:0000128 name: normal asexual spore morphology namespace: single_species_phenotype def: "A reproductive phenotype where the morphology of the asexual spore is normal (FAO:0000023). The product of mitosis." [] synonym: "normal conidia morphology" EXACT [] is_a: PHIPO:0000045 ! normal asexual reproduction created_by: alaynecuzick creation_date: 2018-07-17T13:04:52Z [Term] id: PHIPO:0000129 name: normal asexual reproductive structure development namespace: single_species_phenotype def: "A single species phenotype where the asexual reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals, from their formation to the mature structures is normal (GO:0048608)." [] is_a: PHIPO:0000045 ! normal asexual reproduction created_by: alaynecuzick creation_date: 2018-07-17T13:06:10Z [Term] id: PHIPO:0000130 name: abnormal sexual spore morphology namespace: single_species_phenotype def: "A reproductive phenotype where the morphology of the sexual spore is abnormal (FAO:0000017). The product of meiosis." [] is_a: PHIPO:0000048 ! abnormal sexual reproduction created_by: alaynecuzick creation_date: 2018-07-17T13:09:36Z [Term] id: PHIPO:0000131 name: pathogen host protein-protein interaction phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the binding of one pathogen protein to one host protein. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] is_a: PHIPO:0000164 ! pathogen host interaction binding phenotype created_by: alaynecuzick creation_date: 2018-09-13T13:31:00Z [Term] id: PHIPO:0000132 name: protein-protein interaction phenotype namespace: single_species_phenotype def: "A single species phenotype that affects the binding of one protein to another. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000702 is_a: PHIPO:0000158 ! binding phenotype created_by: alaynecuzick creation_date: 2018-09-13T13:31:27Z [Term] id: PHIPO:0000133 name: abnormal protein-protein interaction namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to another is abnormal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] xref: FYPO:0000704 is_a: PHIPO:0000132 ! protein-protein interaction phenotype is_a: PHIPO:0000413 ! abnormal molecular function created_by: alaynecuzick creation_date: 2018-09-13T13:32:39Z [Term] id: PHIPO:0000134 name: normal protein-protein interaction namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to another is normal (i.e. indistinguishable from wild type). The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] xref: FYPO:0000703 is_a: PHIPO:0000132 ! protein-protein interaction phenotype created_by: alaynecuzick creation_date: 2018-09-13T13:33:02Z [Term] id: PHIPO:0000135 name: abolished protein-protein interaction namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to another does not occur. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] xref: FYPO:0000705 is_a: PHIPO:0000133 ! abnormal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-13T13:33:52Z [Term] id: PHIPO:0000136 name: decreased protein-protein interaction namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to another occurs to a lower extent than normal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] xref: FYPO:0001645 is_a: PHIPO:0000133 ! abnormal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-13T13:34:13Z [Term] id: PHIPO:0000137 name: increased protein-protein interaction namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to another occurs to a greater extent than normal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] xref: FYPO:0001571 is_a: PHIPO:0000133 ! abnormal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-13T13:34:28Z [Term] id: PHIPO:0000138 name: altered protein binding specificity namespace: single_species_phenotype def: "A single species molecular function phenotype in which a mutation causes a gene product to bind to one or more proteins with different specificity from normal. For example, a protein may bind to a protein in a mutant that it does not bind in wild type. The affected gene product may be encoded by the mutated gene, or by a different gene." [] comment: no logical definition in FYPO for 'altered protein binding specificity' xref: FYPO:0005119 is_a: PHIPO:0000133 ! abnormal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-13T13:35:56Z [Term] id: PHIPO:0000139 name: abnormal protein complex binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to a protein complex is abnormal. The protein whose binding to the protein complex is affected may be encoded by the mutated gene, or may be encoded by a different gene." [] xref: FYPO:0003591 is_a: PHIPO:0000133 ! abnormal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-13T13:36:40Z [Term] id: PHIPO:0000140 name: decreased duration of protein-protein interaction namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to another occurs for a shorter time than normal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] comment: logical definition needs checking. xref: FYPO:0005785 is_a: PHIPO:0000133 ! abnormal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-13T13:37:50Z [Term] id: PHIPO:0000141 name: decreased extent and duration of protein-protein interaction namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to another occurs to a lower extent, and for a shorter time, than normal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] comment: logical definition needs checking. xref: FYPO:0005784 is_a: PHIPO:0000133 ! abnormal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-13T13:38:26Z [Term] id: PHIPO:0000142 name: RNA binding phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects RNA binding. The relevant gene product may be encoded by the mutated gene, or by a different gene." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0002131 is_a: PHIPO:0000158 ! binding phenotype created_by: alaynecuzick creation_date: 2018-09-13T13:44:08Z [Term] id: PHIPO:0000143 name: DNA binding phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects DNA binding. The affected gene product may be encoded by the mutated gene, or by a different gene." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000653 is_a: PHIPO:0000158 ! binding phenotype created_by: alaynecuzick creation_date: 2018-09-13T13:44:19Z [Term] id: PHIPO:0000144 name: normal protein complex binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which the binding of one protein to a protein complex is normal (i.e. indistinguishable from wild type). The protein whose binding to the protein complex is assayed may be encoded by the mutated gene, or may be encoded by a different gene." [] xref: FYPO:0005232 is_a: PHIPO:0000134 ! normal protein-protein interaction created_by: alaynecuzick creation_date: 2018-09-24T13:14:19Z [Term] id: PHIPO:0000145 name: abnormal DNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of DNA binding by a gene product is abnormal, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000656 is_a: PHIPO:0000143 ! DNA binding phenotype is_a: PHIPO:0000413 ! abnormal molecular function created_by: alaynecuzick creation_date: 2018-09-25T13:33:07Z [Term] id: PHIPO:0000146 name: normal DNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of DNA binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [] comment: Logical defintion quality (PATO:0000001) and (inheres_in some DNA binding (GO:0003677)) and (qualifier (??) some normal PATO:0000461) xref: FYPO:0000655 is_a: PHIPO:0000143 ! DNA binding phenotype created_by: alaynecuzick creation_date: 2018-09-25T13:33:18Z [Term] id: PHIPO:0000147 name: abolished DNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which DNA binding by a gene product does not occur, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000659 is_a: PHIPO:0000145 ! abnormal DNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:34:30Z [Term] id: PHIPO:0000148 name: altered DNA binding specificity namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which a gene product that normally binds to a specific DNA sequence instead binds to a different sequence when a gene is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] comment: no logical definition for 'altered DNA binding specificity' in FYPO xref: FYPO:0003735 is_a: PHIPO:0000145 ! abnormal DNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:34:56Z [Term] id: PHIPO:0000149 name: decreased DNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of DNA binding by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000658 is_a: PHIPO:0000145 ! abnormal DNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:35:16Z [Term] id: PHIPO:0000150 name: increased DNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of DNA binding by a gene product is increased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000657 is_a: PHIPO:0000145 ! abnormal DNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:35:28Z [Term] id: PHIPO:0000151 name: abnormal multiple protein binding to DNA namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which the binding of two or more proteins to DNA is abnormal. The proteins may bind simultaneously or sequentially, but both or all would normally be present together on DNA at some time. One affected gene product may be encoded by the mutated gene, or all may be encoded by different genes." [] comment: no logical definition for 'abnormal multiple protein binding to DNA' in FYPO xref: FYPO:0006555 is_a: PHIPO:0000145 ! abnormal DNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:36:17Z [Term] id: PHIPO:0000152 name: abnormal RNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of RNA binding by a gene product is abnormal, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002132 is_a: PHIPO:0000142 ! RNA binding phenotype is_a: PHIPO:0000413 ! abnormal molecular function creation_date: 2018-09-25T13:37:19Z [Term] id: PHIPO:0000153 name: normal RNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of RNA binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002357 is_a: PHIPO:0000142 ! RNA binding phenotype created_by: alaynecuzick creation_date: 2018-09-25T13:37:37Z [Term] id: PHIPO:0000154 name: abolished RNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which RNA binding by a gene product does not occur, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002133 is_a: PHIPO:0000152 ! abnormal RNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:37:57Z [Term] id: PHIPO:0000155 name: decreased RNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of RNA binding by a gene product is decreased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002134 is_a: PHIPO:0000152 ! abnormal RNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:38:20Z [Term] id: PHIPO:0000156 name: increased RNA binding namespace: single_species_phenotype def: "A single organism (molecular function??) phenotype in which occurrence of RNA binding by a gene product is increased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002135 is_a: PHIPO:0000152 ! abnormal RNA binding created_by: alaynecuzick creation_date: 2018-09-25T13:38:31Z [Term] id: PHIPO:0000157 name: obsolete motility phenotype namespace: single_species_phenotype comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:11:36Z [Term] id: PHIPO:0000158 name: binding phenotype namespace: single_species_phenotype def: "A single species phenotype that affects the binding of a gene product to another substance. The affected gene product may be encoded by the mutated gene, or by a different gene." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0001092 is_a: PHIPO:0000411 ! molecular function phenotype created_by: alaynecuzick creation_date: 2018-10-01T12:12:12Z [Term] id: PHIPO:0000159 name: normal subcellular component namespace: single_species_phenotype def: "A single species phenotype in which the amount, distribution, composition or morphology of a cell part is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0001233 is_a: PHIPO:0000463 ! subcellular component phenotype created_by: alaynecuzick creation_date: 2018-10-01T12:12:52Z [Term] id: PHIPO:0000160 name: pathogen penetration across barrier phenotype namespace: single_species_phenotype def: "A single species phenotype which affects the pathogen's ability to penetrate a given experimental substance/membrane in an in vitro assay." [] comment: Penetration assays are often performed in vitro to assess pathogen penetration machinery. This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: pathogen_phenotype subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2018-10-01T12:13:47Z [Term] id: PHIPO:0000161 name: reproductive phenotype namespace: single_species_phenotype def: "A single species phenotype which affects the reproductive process. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms (GO:0000003)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2018-10-01T12:14:40Z [Term] id: PHIPO:0000162 name: unicellular population growth phenotype namespace: single_species_phenotype def: "A single species population growth phenotype that affects the rate or extent of the increase in the number of unicellular organisms in the population (i.e organismal growth and reproduction)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000509 ! population phenotype created_by: alaynecuzick creation_date: 2018-10-01T12:15:24Z [Term] id: PHIPO:0000164 name: pathogen host interaction binding phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the binding of a gene product to another substance. The affected gene product may be encoded by the mutated gene, or by a different gene." [] is_a: PHIPO:0000347 ! pathogen host interaction molecular function phenotype created_by: alaynecuzick creation_date: 2018-10-01T12:21:51Z [Term] id: PHIPO:0000165 name: obsolete abnormal host lesion formation with pathogen namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:22:45Z [Term] id: PHIPO:0000166 name: obsolete chlorosis phenotype namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:46:24Z [Term] id: PHIPO:0000167 name: obsolete pathogen host interaction RNA binding phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects RNA binding. The relevant gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002131 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:54:51Z [Term] id: PHIPO:0000168 name: obsolete abnormal pathogen host interaction RNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of RNA binding by a gene product is abnormal, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002132 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:56:01Z [Term] id: PHIPO:0000169 name: obsolete chlorosis absent namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:56:11Z [Term] id: PHIPO:0000170 name: obsolete chlorosis present namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:57:11Z [Term] id: PHIPO:0000171 name: obsolete normal pathogen host interaction RNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of RNA binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002357 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T12:57:15Z [Term] id: PHIPO:0000172 name: obsolete abolished pathogen host interaction RNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which RNA binding by a gene product does not occur, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002133 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:04:43Z [Term] id: PHIPO:0000173 name: abolished filamentous growth on host surface namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype where the vegetative growth or proliferation of the pathogen on the host surface is abolished (it was present and is now absent)." [] is_a: PHIPO:0000350 ! absence of pathogen growth on host surface created_by: alaynecuzick creation_date: 2018-10-01T13:04:47Z [Term] id: PHIPO:0000174 name: obsolete decreased pathogen host interaction RNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of RNA binding by a gene product is decreased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002134 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:05:26Z [Term] id: PHIPO:0000175 name: obsolete normal pathogen growth on host surface namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype where the vegetative growth or proliferation of the pathogen on the host surface is normal." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:05:29Z [Term] id: PHIPO:0000176 name: obsolete increased pathogen host interaction RNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of RNA binding by a gene product is increased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0002135 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:05:50Z [Term] id: PHIPO:0000177 name: obsolete yeast-form growth phenotype namespace: single_species_phenotype def: "A single species population phenotype in which affects the population growth during the yeast-form lifecycle stage." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:05:53Z [Term] id: PHIPO:0000178 name: obsolete pathogen host interaction DNA binding phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects DNA binding. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000653 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:09:13Z [Term] id: PHIPO:0000180 name: obsolete abnormal pathogen host interaction DNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of DNA binding by a gene product is abnormal, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000656 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:09:23Z [Term] id: PHIPO:0000182 name: absence of host-defense induced lesion by host hypersensitive response namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000186 def: "A phenotype where the process of host tissue cell death causing a host lesion is induced by the host activating its own hypersensitive response in defense, is absent." [] comment: This term is to be used for host protection against the pathogen. Note that if you are curating a necrotroph you need to annotate to PHIPO:0000465. synonym: "abolished effector-mediated host hypersensitive response during biotrophy" RELATED [] synonym: "abolished host HR induced by pathogen during biotrophy" EXACT [] synonym: "abolished host lesion" RELATED [] synonym: "abolished host necrotic cell death" RELATED [] synonym: "absence of effector-mediated host hypersensitive response during biotrophy" RELATED [] synonym: "absence of host HR induced by pathogen during biotrophy" EXACT [] synonym: "absence of host lesion" RELATED [] synonym: "absence of host necrotic cell death" RELATED [] is_a: PHIPO:0000481 ! absence of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2018-10-01T13:09:35Z [Term] id: PHIPO:0000183 name: obsolete normal pathogen host interaction DNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of DNA binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [] comment: Logical defintion quality (PATO:0000001) and (inheres_in some DNA binding (GO:0003677)) and (qualifier (??) some normal PATO:0000461) xref: FYPO:0000655 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:09:42Z [Term] id: PHIPO:0000184 name: obsolete pathogen adhesion to host phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:12:32Z [Term] id: PHIPO:0000185 name: obsolete abnormal pathogen host interaction multiple protein binding to DNA namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which the binding of two or more proteins to DNA is abnormal. The proteins may bind simultaneously or sequentially, but both or all would normally be present together on DNA at some time. One affected gene product may be encoded by the mutated gene, or all may be encoded by different genes." [] xref: FYPO:0006555 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:12:43Z [Term] id: PHIPO:0000187 name: obsolete abolished pathogen host interaction DNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which DNA binding by a gene product does not occur, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000659 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:13:16Z [Term] id: PHIPO:0000188 name: pathogen growth on host surface phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype which affects the vegetative growth or proliferation of the pathogen on the host surface." [] is_a: PHIPO:0000332 ! pathogen colonization of host phenotype created_by: alaynecuzick creation_date: 2018-10-01T13:13:27Z [Term] id: PHIPO:0000189 name: obsolete altered pathogen host interaction DNA binding specificity namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which a gene product that normally binds to a specific DNA sequence instead binds to a different sequence when a gene is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0003735 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:13:36Z [Term] id: PHIPO:0000190 name: delayed host-defense induced lesion formation by host hypersensitive response namespace: pathogen_host_interaction_phenotype def: "A phenotype where the process of host tissue cell death causing a host lesion is induced by the host activating its own hypersensitive response in defense is delayed." [] comment: This term is to be used for host protection against the pathogen. synonym: "delayed effector-mediated host hypersensitive response during biotrophy" RELATED [] synonym: "delayed host necrotic cell death" RELATED [] synonym: "delayed presence of host lesion" RELATED [] is_a: PHIPO:0000192 ! presence of host-defense induced lesion by host hypersensitive response is_a: PHIPO:0000985 ! decreased extent of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2018-10-01T13:14:10Z [Term] id: PHIPO:0000191 name: obsolete decreased pathogen host interaction DNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of DNA binding by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000658 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:14:20Z [Term] id: PHIPO:0000192 name: presence of host-defense induced lesion by host hypersensitive response namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000516 def: "A phenotype where the process of host tissue cell death causing a host lesion is induced by the host activating its own hypersensitive response in defense, is present." [] comment: This term is to be used for host protection against the pathogen. Note that if you are curating a necrotroph you need to annotate to PHIPO:0000477. synonym: "gain of effector-mediated host hypersensitive response during biotrophy" RELATED [] synonym: "gain of host necrotic cell death" RELATED [] synonym: "gain of presence of host lesion" RELATED [] synonym: "presence of effector-mediated host hypersensitive response during biotrophy" RELATED [] synonym: "presence of host lesion" RELATED [] synonym: "presence of host necrotic cell death" RELATED [] is_a: PHIPO:0000461 ! presence of pathogen-associated host defense induced lesions created_by: alaynecuzick creation_date: 2018-10-01T13:14:29Z [Term] id: PHIPO:0000193 name: obsolete increased pathogen host interaction DNA binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which occurrence of DNA binding by a gene product is increased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] xref: FYPO:0000657 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:14:39Z [Term] id: PHIPO:0000195 name: obsolete normal host lesion formation with pathogen namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:26:34Z [Term] id: PHIPO:0000196 name: normal aerial height of filament namespace: single_species_phenotype def: "An individual organism growth phenotype in which the aerial height of hyphae is normal (indistinguishable from wild type)." [] comment: Although this phenotype is for an individual it can be inferred from a population in a colony. synonym: "normal aerial height of filamentous colony" RELATED [] is_a: PHIPO:0001210 ! normal hyphal growth created_by: alaynecuzick creation_date: 2018-10-01T13:27:25Z [Term] id: PHIPO:0000197 name: obsolete abnormal pathogen host protein protein interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which the binding of one protein to another is abnormal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] xref: FYPO:0000704 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:27:34Z [Term] id: PHIPO:0000198 name: obsolete pathogen host interaction transporter phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects a transporter activity." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:27:49Z [Term] id: PHIPO:0000199 name: obsolete normal pathogen host protein protein interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which the binding of one protein to another is normal (i.e. indistinguishable from wild type). The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [] xref: FYPO:0000703 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:27:56Z [Term] id: PHIPO:0000200 name: host chlorosis phenotype in presence of pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen-host interaction phenotype in which leaves produce insufficient chlorophyll." [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2018-10-01T13:28:13Z [Term] id: PHIPO:0000201 name: obsolete normal pathogen host protein complex binding namespace: pathogen_host_interaction_phenotype def: "A pathogen (molecular function??) phenotype in which the binding of one protein to a protein complex is normal (i.e. indistinguishable from wild type). The protein whose binding to the protein complex is assayed may be encoded by the mutated gene, or may be encoded by a different gene." [] xref: FYPO:0005232 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:28:22Z [Term] id: PHIPO:0000202 name: obsolete abnormal pathogen host protein complex binding namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (molecular function??) phenotype in which the binding of one protein to a protein complex is abnormal. The protein whose binding to the protein complex is affected may be encoded by the mutated gene, or may be encoded by a different gene." [] xref: FYPO:0003591 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:31:30Z [Term] id: PHIPO:0000203 name: obsolete increased aerial height of filamentous colony affecting colony shape namespace: single_species_phenotype def: "A single species hyphal colony shape phenotype where the aerial height of the filamentous colony is increased." [] synonym: "increased aerial height of filamentous colony" RELATED [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:31:34Z [Term] id: PHIPO:0000205 name: decreased aerial height of filament namespace: single_species_phenotype def: "An individual organism growth phenotype in which the aerial height of hyphae is decreased." [] comment: Although this phenotype is for an individual it can be inferred from a population in a colony. synonym: "decreased aerial height of filamentous colony" RELATED [] is_a: PHIPO:0001212 ! decreased hyphal growth created_by: alaynecuzick creation_date: 2018-10-01T13:32:01Z [Term] id: PHIPO:0000206 name: obsolete altered pathogen and host protein binding specificity namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of one pathogen protein to one host protein occurs with a different specificity than normal." [] xref: FYPO:0005119 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:32:15Z [Term] id: PHIPO:0000207 name: loss of mutualism namespace: pathogen_host_interaction_phenotype def: "A phenotype in which the balance of symbiotic mutualism has been disrupted compared to the normal interaction and the endosymbiont organism is able to show greater biomass within the host and/or the formation of visible disease formation symptoms compared to the normal interaction." [] subset: qc_extension_only is_a: PHIPO:0000040 ! abnormal mutualism created_by: alaynecuzick creation_date: 2018-10-01T13:32:18Z [Term] id: PHIPO:0000208 name: obsolete decreased duration of pathogen host protein-protein interaction namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of one pathogen protein to one host protein occurs for a shorter time than normal." [] xref: FYPO:0005785 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:32:28Z [Term] id: PHIPO:0000209 name: obsolete increased stature namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:32:31Z [Term] id: PHIPO:0000210 name: obsolete decreased extent and duration of pathogen host protein-protein interaction namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of one pathogen protein to one host protein occurs to a lower extent, and for a shorter time, than normal." [] xref: FYPO:0005784 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:32:42Z [Term] id: PHIPO:0000211 name: obsolete decreased stature namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:32:46Z [Term] id: PHIPO:0000212 name: decreased pathogen host protein-protein interaction namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of one pathogen protein to one host protein occurs to a lesser extent than normal." [] xref: FYPO:0001645 is_a: PHIPO:0001106 ! presence of pathogen host protein-protein interaction created_by: alaynecuzick creation_date: 2018-10-01T13:33:00Z [Term] id: PHIPO:0000213 name: host chlorosis absent in presence of pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen-host interaction phenotype in which host chlorosis is absent." [] is_a: PHIPO:0000200 ! host chlorosis phenotype in presence of pathogen created_by: alaynecuzick creation_date: 2018-10-01T13:33:03Z [Term] id: PHIPO:0000214 name: increased pathogen host protein-protein interaction namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of one pathogen protein to one host protein occurs to a greater extent than normal." [] xref: FYPO:0001571 is_a: PHIPO:0001106 ! presence of pathogen host protein-protein interaction created_by: alaynecuzick creation_date: 2018-10-01T13:33:15Z [Term] id: PHIPO:0000215 name: host chlorosis present in presence of pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen-host interaction phenotype in which host chlorosis is present." [] is_a: PHIPO:0000200 ! host chlorosis phenotype in presence of pathogen created_by: alaynecuzick creation_date: 2018-10-01T13:33:18Z [Term] id: PHIPO:0000216 name: obsolete pathogen host interaction disease symptom phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:42:29Z [Term] id: PHIPO:0000217 name: obsolete pathogen host interaction primary metabolic process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [] comment: Definition adapted from GO:0044238 primary metabolic process xref: GO:0044238 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:43:20Z [Term] id: PHIPO:0000218 name: obsolete abnormal pathogen host interaction toxin biosynthetic process namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the toxin biosynthetic process is abnormal (i.e. different than the wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-01T13:43:40Z [Term] id: PHIPO:0000219 name: decreased level of pathogen deoxynivalenol within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen produced deoxynivalenol usually present during infection is lower than normal." [] synonym: "decreased level of pathogen DON within host" EXACT [] synonym: "decreased level of pathogen vomitoxin within host" EXACT [] is_a: PHIPO:0001045 ! decreased level of pathogen produced toxin within host created_by: alaynecuzick creation_date: 2018-10-01T13:44:10Z [Term] id: PHIPO:0000220 name: obsolete pathogen host interaction metabolic process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [] comment: Definition adapted from GO_0008152 metabolic process xref: GO_0008152 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T08:53:44Z [Term] id: PHIPO:0000224 name: obsolete altered colour of host lesion with pathogen namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T08:59:23Z [Term] id: PHIPO:0000226 name: obsolete pathogen host interaction secondary metabolite biosynthetic process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [] comment: Definition adapted from GO:0044550 secondary metabolite biosynthetic process xref: GO:0044550 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T09:09:52Z [Term] id: PHIPO:0000227 name: obsolete pathogen host interaction secondary metabolic process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [] comment: Definition adapted from GO:0019748 secondary metabolic process xref: GO:0019748 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T09:10:09Z [Term] id: PHIPO:0000228 name: obsolete normal pathogen host interaction biosynthesis of deoxynivalenol namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the pathogen biosynthesis of deoxynivalenol is normal (i.e. same as the wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T09:12:44Z [Term] id: PHIPO:0000229 name: obsolete abnormal pathogen host interaction biosynthesis of deoxynivalenol namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the pathogen biosynthesis of deoxynivalenol is abnormal (i.e. different than the wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T09:12:59Z [Term] id: PHIPO:0000230 name: obsolete normal pathogen host interaction toxin biosynthetic process namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the toxin biosynthetic process is normal (i.e. same as the wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T09:15:34Z [Term] id: PHIPO:0000231 name: obsolete pathogen host interaction toxin biosynthetic process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [] comment: Definition adapted fromo GO:0009403 toxin biosynthetic process xref: GO:0009403 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T09:17:44Z [Term] id: PHIPO:0000232 name: increased level of pathogen deoxynivalenol within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen produced deoxynivalenol usually present during infection is higher than normal." [] synonym: "increased level of pathogen DON within host" EXACT [] synonym: "increased level of pathogen vomitoxin within host" EXACT [] is_a: PHIPO:0001046 ! increased level of pathogen produced toxin within host created_by: alaynecuzick creation_date: 2018-10-02T09:18:35Z [Term] id: PHIPO:0000233 name: pathogen deoxynivalenol within host present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the pathogen produced deoxynivalenol usually present during infection is present as normal (i.e. indistinguishable from wild type)." [] synonym: "pathogen DON within host present" EXACT [] synonym: "pathogen vomitoxin within host present" EXACT [] synonym: "presence of pathogen deoxynivalenol within host" RELATED [] is_a: PHIPO:0001043 ! level of pathogen produced toxin within host phenotype created_by: alaynecuzick creation_date: 2018-10-02T09:19:27Z [Term] id: PHIPO:0000234 name: pathogen deoxynivalenol within host absent namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the pathogen produced deoxynivalenol usually present during infection is absent or at a level too low to detect." [] synonym: "absence of pathogen deoxynivalenol within host" RELATED [] synonym: "pathogen DON within host absent" EXACT [] synonym: "pathogen vomitoxin within host absent" EXACT [] is_a: PHIPO:0001047 ! pathogen toxin within host absent created_by: alaynecuzick creation_date: 2018-10-02T09:20:17Z [Term] id: PHIPO:0000235 name: localization phenotype namespace: single_species_phenotype def: "A single species phenotype that affects the localization of a structure or substance in a cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000138 is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:12:56Z [Term] id: PHIPO:0000236 name: pathogen host interaction localization phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the localization of a structure or substance in a cell." [] comment: Note that this term was reinstated from obsolete. comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000510 ! pathogen host interaction cell phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:13:04Z [Term] id: PHIPO:0000237 name: protein localization phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the localization of a protein in a cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0002333 is_a: PHIPO:0000235 ! localization phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:13:36Z [Term] id: PHIPO:0000238 name: obsolete pathogen host interaction protein localization phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the localization of a protein in a cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0002333 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:13:39Z [Term] id: PHIPO:0000239 name: abnormal protein localization namespace: single_species_phenotype def: "A single organism phenotype in which the localization of a protein in a cell is abnormal. A protein may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [] xref: FYPO:0001370 is_a: PHIPO:0000237 ! protein localization phenotype is_a: PHIPO:0000929 ! abnormal cellular process is_a: PHIPO:0001094 ! abnormal localization created_by: alaynecuzick creation_date: 2018-10-02T10:14:02Z [Term] id: PHIPO:0000240 name: abnormal pathogen protein localization within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the localization of a pathogen protein in a host cell differs from normal." [] is_a: PHIPO:0000236 ! pathogen host interaction localization phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:14:05Z [Term] id: PHIPO:0000241 name: abnormal protein complex localization namespace: single_species_phenotype def: "A single organism phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein complex is abnormal." [] xref: FYPO:0001440 is_a: PHIPO:0000239 ! abnormal protein localization created_by: alaynecuzick creation_date: 2018-10-02T10:14:50Z [Term] id: PHIPO:0000242 name: obsolete abnormal pathogen host interaction protein complex localization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein complex is abnormal." [] xref: FYPO:0001440 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:14:53Z [Term] id: PHIPO:0000243 name: obsolete abnormal pathogen host interaction protein localization to nucleus namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of a protein to the nucleus is abnormal. (Which nucleus? pathogen or host?)" [] comment: Encompasses both presence of proteins not normally found in the nucleus and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. xref: FYPO:0002956 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:16:31Z [Term] id: PHIPO:0000244 name: abnormal protein localization to nucleus namespace: single_species_phenotype def: "A single organism phenotype in which the localization of a protein to the nucleus is abnormal." [] comment: Encompasses both presence of proteins not normally found in the nucleus and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. xref: FYPO:0002956 is_a: PHIPO:0000239 ! abnormal protein localization created_by: alaynecuzick creation_date: 2018-10-02T10:16:37Z [Term] id: PHIPO:0000245 name: abolished protein localization namespace: single_species_phenotype def: "A single organism phenotype in which a protein does not localize to, and is therefore absent from, a place where it is normally found." [] comment: If this term is used, we recommend noting which protein(s) were used in the assay. xref: FYPO:0001375 is_a: PHIPO:0000239 ! abnormal protein localization created_by: alaynecuzick creation_date: 2018-10-02T10:17:52Z [Term] id: PHIPO:0000246 name: abolished pathogen protein localization within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of a pathogen protein to a host structure or compartment is abolished (i.e. the protein was localized to the host structure or compartment and now is not)." [] comment: If this term is used, we recommend noting which protein(s) were used in the assay. xref: FYPO:0001375 is_a: PHIPO:0000240 ! abnormal pathogen protein localization within host created_by: alaynecuzick creation_date: 2018-10-02T10:17:55Z [Term] id: PHIPO:0000247 name: abolished pathogen protein localization to host nucleus namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of a pathogen protein to the host nucleus is abolished." [] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. xref: FYPO:0003450 is_a: PHIPO:0000246 ! abolished pathogen protein localization within host created_by: alaynecuzick creation_date: 2018-10-02T10:19:22Z [Term] id: PHIPO:0000248 name: abolished protein localization to nucleus namespace: single_species_phenotype def: "A single organism phenotype in which the localization of a protein to the nucleus is abolished (GO:0034504)." [] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. xref: FYPO:0003450 is_a: PHIPO:0000245 ! abolished protein localization created_by: alaynecuzick creation_date: 2018-10-02T10:19:27Z [Term] id: PHIPO:0000249 name: RNA localization phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the localization of an RNA in a cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0004853 is_a: PHIPO:0000235 ! localization phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:20:15Z [Term] id: PHIPO:0000250 name: obsolete pathogen host interaction RNA localization phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the localization of an RNA in a cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0004853 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:20:17Z [Term] id: PHIPO:0000251 name: abnormal RNA localization namespace: single_species_phenotype def: "A single organism phenotype in which the localization of an RNA in a cell is abnormal. An RNA may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [] xref: FYPO:0003057 is_a: PHIPO:0000249 ! RNA localization phenotype is_a: PHIPO:0001094 ! abnormal localization created_by: alaynecuzick creation_date: 2018-10-02T10:20:49Z [Term] id: PHIPO:0000252 name: obsolete abnormal pathogen host interaction RNA localization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of an RNA in a cell is abnormal. An RNA may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [] xref: FYPO:0003057 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:20:53Z [Term] id: PHIPO:0000253 name: normal RNA localization namespace: single_species_phenotype def: "A single organism phenotype in which the localization of an RNA in a cell is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0003058 is_a: PHIPO:0000249 ! RNA localization phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:21:19Z [Term] id: PHIPO:0000254 name: obsolete normal pathogen host interaction RNA localization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of an RNA in a cell is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0003058 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:21:22Z [Term] id: PHIPO:0000255 name: obsolete pathogen host interaction transport phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (cell process???) phenotype that affects a transport process." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000149 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:21:45Z [Term] id: PHIPO:0000256 name: transport phenotype namespace: single_species_phenotype def: "A single organism cell phenotype that affects a transport process." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000149 is_a: PHIPO:0000235 ! localization phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:21:48Z [Term] id: PHIPO:0000257 name: abnormal transport namespace: single_species_phenotype def: "A single organism phenotype in which a specific transport process is abnormal." [] xref: FYPO:0001720 is_a: PHIPO:0000256 ! transport phenotype is_a: PHIPO:0001094 ! abnormal localization created_by: alaynecuzick creation_date: 2018-10-02T10:22:11Z [Term] id: PHIPO:0000258 name: obsolete abnormal pathogen host interaction transport namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which a specific transport process is abnormal." [] xref: FYPO:0001720 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:22:15Z [Term] id: PHIPO:0000259 name: normal protein transport namespace: single_species_phenotype def: "A single organism cellular process phenotype in which protein transport is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0005747 is_a: PHIPO:0000256 ! transport phenotype created_by: alaynecuzick creation_date: 2018-10-02T10:22:37Z [Term] id: PHIPO:0000260 name: obsolete normal pathogen host interaction protein transport namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (cellular process??) phenotype in which protein transport is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0005747 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:22:40Z [Term] id: PHIPO:0000261 name: abnormal endocytosis namespace: single_species_phenotype def: "A single organism cellular process phenotype in which endocytosis is abnormal. Endocytosis is a vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [] xref: FYPO:0003886 is_a: PHIPO:0000257 ! abnormal transport is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-10-02T10:22:57Z [Term] id: PHIPO:0000262 name: obsolete abnormal pathogen host interaction endocytosis namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (cellular process???) phenotype in which endocytosis is abnormal. Endocytosis is a vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [] xref: FYPO:0003886 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:23:00Z [Term] id: PHIPO:0000263 name: abnormal nuclear transport namespace: single_species_phenotype def: "A single organism cellular process phenotype in which nuclear transport is abnormal." [] xref: FYPO:0005573 is_a: PHIPO:0000257 ! abnormal transport is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-10-02T10:23:27Z [Term] id: PHIPO:0000264 name: obsolete abnormal pathogen host interaction nuclear transport namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (cellular process??) phenotype in which nuclear transport is abnormal." [] xref: FYPO:0005573 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:23:30Z [Term] id: PHIPO:0000265 name: abnormal protein transport namespace: single_species_phenotype def: "A single organism cellular process phenotype in which protein transport is abnormal." [] xref: FYPO:0005744 is_a: PHIPO:0000239 ! abnormal protein localization is_a: PHIPO:0000257 ! abnormal transport created_by: alaynecuzick creation_date: 2018-10-02T10:24:39Z [Term] id: PHIPO:0000266 name: obsolete abnormal pathogen host interaction protein transport namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (cellular process??) phenotype in which protein transport is abnormal." [] xref: FYPO:0005744 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:24:41Z [Term] id: PHIPO:0000267 name: abnormal vacuolar transport namespace: single_species_phenotype def: "A single organism cellular process phenotype in which vacuolar transport is abnormal." [] xref: FYPO:0003578 is_a: PHIPO:0000257 ! abnormal transport is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-10-02T10:24:58Z [Term] id: PHIPO:0000268 name: obsolete abnormal pathogen host interaction vacuolar transport namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction (cellular process??) phenotype in which vacuolar transport is abnormal." [] xref: FYPO:0003578 is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-02T10:25:00Z [Term] id: PHIPO:0000269 name: normal protein localization namespace: single_species_phenotype def: "A single organism phenotype in which the localization of a protein in a cell is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0003627 is_a: PHIPO:0000237 ! protein localization phenotype created_by: alaynecuzick creation_date: 2018-10-03T11:05:06Z [Term] id: PHIPO:0000270 name: normal pathogen protein and host protein colocalization within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the colocalization of a pathogen protein and a host protein within a host cell is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0000236 ! pathogen host interaction localization phenotype created_by: alaynecuzick creation_date: 2018-10-03T11:05:09Z [Term] id: PHIPO:0000271 name: normal protein localization to nucleus namespace: single_species_phenotype def: "A single organism phenotype in which the localization of a protein to the nucleus is normal (i.e. indistinguishable from wild type)(GO:0034504)." [] xref: FYPO:0006553 is_a: PHIPO:0000269 ! normal protein localization created_by: alaynecuzick creation_date: 2018-10-03T11:05:29Z [Term] id: PHIPO:0000272 name: normal pathogen protein localization to host nucleus namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of a pathogen protein to the host nucleus is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0006553 is_a: PHIPO:0001175 ! normal pathogen protein localization within host created_by: alaynecuzick creation_date: 2018-10-03T11:05:31Z [Term] id: PHIPO:0000274 name: increased asexual spore germination frequency namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spore germination is increased." [] synonym: "increased conidia germination frequency" EXACT [] is_a: PHIPO:0000509 ! population phenotype is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-10-03T13:38:33Z [Term] id: PHIPO:0000275 name: abnormal tissue phenotype namespace: single_species_phenotype def: "A phenotype that shows detectable differences from normal at the level of a tissue (eg leaf, inflorescence, ear or kidney)." [] is_a: PHIPO:0000003 ! tissue phenotype created_by: alaynecuzick creation_date: 2018-10-03T13:39:04Z [Term] id: PHIPO:0000276 name: normal tissue phenotype namespace: single_species_phenotype def: "A phenotype that does not show any detectable differences from normal at the level of a tissue (eg leaf, inflorescence, ear or kidney)." [] is_a: PHIPO:0000003 ! tissue phenotype created_by: alaynecuzick creation_date: 2018-10-03T13:39:23Z [Term] id: PHIPO:0000277 name: obsolete abnormal filamentous growth namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-03T13:39:41Z [Term] id: PHIPO:0000279 name: obsolete systemic phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-03T13:43:37Z [Term] id: PHIPO:0000280 name: pathogen effector mediated modulation of host immune system process namespace: pathogen_host_interaction_phenotype def: "A phenotype dependent on an interaction between a pathogen effector and a host process in order for the pathogen to activate or suppress the host immune system. An effector is an entity derived from a pathogenic or non-pathogenic species that either activates or suppresses host defenses or other host responses." [] comment: To annotate a metagenotype containing a pathogen effector use 'GO:0140418 effector-mediated modulation of host process by symbiont' or a descendant. This is only to be used when there is manipulation of the host. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0001167 ! pathogen modulation of host immune system process phenotype created_by: alaynecuzick creation_date: 2018-10-05T11:00:39Z [Term] id: PHIPO:0000281 name: obsolete stature phenotype namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:33:43Z [Term] id: PHIPO:0000282 name: obsolete abnormal stature namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:33:56Z [Term] id: PHIPO:0000283 name: obsolete normal stature namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:34:05Z [Term] id: PHIPO:0000284 name: pigment phenotype namespace: single_species_phenotype def: "A single species individual organism phenotype affecting the deposition or aggregation of coloring matter in a cell." [] is_a: PHIPO:0000402 ! individual organism phenotype created_by: alaynecuzick creation_date: 2018-10-05T12:37:03Z [Term] id: PHIPO:0000285 name: abnormal cellular pigment accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in a cell is abnormal." [] is_a: PHIPO:0000284 ! pigment phenotype created_by: alaynecuzick creation_date: 2018-10-05T12:37:16Z [Term] id: PHIPO:0000286 name: normal cellular pigment accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in a cell is normal." [] is_a: PHIPO:0000284 ! pigment phenotype created_by: alaynecuzick creation_date: 2018-10-05T12:37:24Z [Term] id: PHIPO:0000287 name: increased cellular pigment accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in a cell is increased." [] is_a: PHIPO:0000285 ! abnormal cellular pigment accumulation is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-10-05T12:38:26Z [Term] id: PHIPO:0000288 name: decreased cellular pigment accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in a cell is decreased." [] is_a: PHIPO:0000285 ! abnormal cellular pigment accumulation is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-10-05T12:38:39Z [Term] id: PHIPO:0000289 name: obsolete altered colour namespace: single_species_phenotype subset: host_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:38:58Z [Term] id: PHIPO:0000290 name: obsolete colour present namespace: single_species_phenotype subset: host_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:39:18Z [Term] id: PHIPO:0000291 name: obsolete colour absent namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:39:26Z [Term] id: PHIPO:0000292 name: decreased filament length namespace: single_species_phenotype def: "A single species cell morphology phenotype where hyphal filaments are short in length." [] synonym: "reduced filament length" EXACT [] is_a: PHIPO:0001205 ! abnormal filament morphology created_by: alaynecuzick creation_date: 2018-10-05T12:43:16Z [Term] id: PHIPO:0000293 name: obsolete abnormal organism morphology phenotype namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:48:26Z [Term] id: PHIPO:0000294 name: obsolete normal organism morphology phenotype namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:52:54Z [Term] id: PHIPO:0000295 name: sinusoidal filament namespace: single_species_phenotype def: "A single species cell morphology phenotype where hyphal filaments are wavy." [] synonym: "wavy hyphae" EXACT [] is_a: PHIPO:0001205 ! abnormal filament morphology created_by: alaynecuzick creation_date: 2018-10-05T12:53:20Z [Term] id: PHIPO:0000296 name: obsolete normal dissemination of pathogen asexual product namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:56:56Z [Term] id: PHIPO:0000297 name: obsolete normal dissemination of pathogen sexual product namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:57:37Z [Term] id: PHIPO:0000298 name: obsolete abnormal dissemination of pathogen asexual product namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:58:29Z [Term] id: PHIPO:0000299 name: obsolete abnormal dissemination of pathogen sexual product namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-05T12:58:58Z [Term] id: PHIPO:0000300 name: abnormal dissemination of asexual spore namespace: single_species_phenotype def: "A single species phenotype where the dispersal of asexual spores is abnormal (FAO:0000023)." [] synonym: "abnormal dissemination of conidia" EXACT [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2018-10-05T13:00:13Z [Term] id: PHIPO:0000301 name: normal dissemination of asexual spore namespace: single_species_phenotype def: "A single species phenotype where the dispersal of asexual spores is normal (FAO:0000023)." [] synonym: "normal dissemination of conidia" EXACT [] is_a: PHIPO:0000044 ! normal reproduction phenotype created_by: alaynecuzick creation_date: 2018-10-05T13:00:21Z [Term] id: PHIPO:0000302 name: normal dissemination of sexual spore namespace: single_species_phenotype def: "A single species phenotype where the dispersal of sexual spores is normal (FAO:0000017)." [] is_a: PHIPO:0000044 ! normal reproduction phenotype created_by: alaynecuzick creation_date: 2018-10-05T13:00:34Z [Term] id: PHIPO:0000303 name: abnormal dissemination of sexual spore namespace: single_species_phenotype def: "A single species phenotype where the dispersal of sexual spores is abnormal (FAO:0000017)." [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2018-10-05T13:00:37Z [Term] id: PHIPO:0000305 name: obsolete effector of pathogenicity phenotype namespace: pathogen_host_interaction_phenotype def: "(Required for successful infection of the host species). The ability of an organism to activate or suppress host defenses to enable infectious disease. (Irrespective of the host genotype)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T12:55:58Z [Term] id: PHIPO:0000306 name: obsolete abnormal effector of virulence namespace: pathogen_host_interaction_phenotype def: "The host defenses activated by the pathogen are altered compared to the wild type interaction" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T12:56:08Z [Term] id: PHIPO:0000307 name: obsolete normal effector of pathogenicity namespace: pathogen_host_interaction_phenotype def: "The ability to cause disease by activating or suppressing host defenses is unaltered compared to the wildtype interaction. This may result in the outcome of being pathogenic or not-pathogenic." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T12:58:41Z [Term] id: PHIPO:0000308 name: obsolete normal effector of pathogenicity activation of host defense namespace: pathogen_host_interaction_phenotype def: "The host defenses activated by the pathogen are unaltered compared to the wild type interaction" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T12:59:50Z [Term] id: PHIPO:0000309 name: obsolete normal effector of pathogenicity suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The host defenses suppressed by the pathogen are unaltered compared to the wild type interaction" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:11:15Z [Term] id: PHIPO:0000310 name: obsolete normal effector of virulence namespace: pathogen_host_interaction_phenotype def: "The pathogen has the ability to cause infectious disease dependent upon the gene for gene relationship between the pathogen and host genotype and this is unaltered compared to the wildtype interaction. This may result in disease (virulence) or no disease (avirulence)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:12:40Z [Term] id: PHIPO:0000311 name: obsolete effector of virulence phenotype namespace: pathogen_host_interaction_phenotype def: "(gene for gene relationships) or defined from the phenotype described in the published study. The pathogen has the ability to cause infectious disease dependent upon the gene for gene relationship between the pathogen and host genotype." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:14:06Z [Term] id: PHIPO:0000312 name: obsolete abnormal effector of pathogenicity namespace: pathogen_host_interaction_phenotype def: "The ability to cause disease by activating or suppressing host defenses is altered compared to the wildtype interaction." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:15:10Z [Term] id: PHIPO:0000313 name: obsolete normal effector of virulence activation of host defense namespace: pathogen_host_interaction_phenotype def: "The host defenses activated by the pathogen are unaltered compared to the wild type interaction" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:22:08Z [Term] id: PHIPO:0000314 name: obsolete normal effector of virulence suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The host defenses suppressed by the pathogen are unaltered compared to the wild type interaction" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:22:20Z [Term] id: PHIPO:0000315 name: obsolete abnormal effector of virulence activation of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen has the ability to cause infectious disease dependent upon the gene for gene relationship between the pathogen and host genotype and this is altered compared to the wildtype interaction. This may result in disease (virulence) or no disease (avirulence)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:25:51Z [Term] id: PHIPO:0000316 name: obsolete decreased effector of virulence activation of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has a decreased ability to activate host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:26:40Z [Term] id: PHIPO:0000317 name: obsolete increased effector of virulence activation of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has an increased ability to activate host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:27:34Z [Term] id: PHIPO:0000318 name: obsolete abnormal effector of virulence suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The host defenses suppressed by the pathogen are altered compare to the wild type interaction" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:28:11Z [Term] id: PHIPO:0000319 name: obsolete decreased effector of virulence suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has a decreased ability to suppress host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:28:53Z [Term] id: PHIPO:0000320 name: obsolete increased effector of virulence suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has an increased ability to suppress host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:29:31Z [Term] id: PHIPO:0000321 name: obsolete abnormal effector of pathogenicity activation of host defense namespace: pathogen_host_interaction_phenotype def: "The host defenses activated by the pathogen are altered compared to the wild type interaction." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:31:28Z [Term] id: PHIPO:0000322 name: obsolete gain of effector of pathogenicity activation of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has gained the ability to activate host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:32:29Z [Term] id: PHIPO:0000323 name: obsolete loss of effector of pathogenicity activation of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has lost the ability to activate host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:32:51Z [Term] id: PHIPO:0000324 name: obsolete abnormal effector of pathogenicity suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The host defenses suppressed by the pathogen are altered compared to the wild type interaction" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:33:53Z [Term] id: PHIPO:0000325 name: obsolete gain of effector of pathogenicity suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has gained the ability to suppress host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:34:13Z [Term] id: PHIPO:0000326 name: obsolete loss of effector of pathogenicity suppression of host defense namespace: pathogen_host_interaction_phenotype def: "The pathogen effector entity has lost the ability to suppress host defense." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-18T13:34:33Z [Term] id: PHIPO:0000327 name: resistance to cyproconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cypronazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-10-19T13:41:59Z [Term] id: PHIPO:0000328 name: normal cellular component organization namespace: single_species_phenotype def: "A cellular process phenotype in which any process of cellular component organization at the cellular level is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0006003 is_a: PHIPO:0000407 ! cellular component organization phenotype created_by: alaynecuzick creation_date: 2018-10-19T13:42:19Z [Term] id: PHIPO:0000329 name: sensitive to cyproconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cyproconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-10-19T13:42:46Z [Term] id: PHIPO:0000330 name: abnormal transporter activity namespace: single_species_phenotype def: "A molecular function phenotype in which the observed rate of a specified transporter activity is abnormal." [] xref: FYPO:0002116 is_a: PHIPO:0000409 ! transporter activity phenotype is_a: PHIPO:0000413 ! abnormal molecular function created_by: alaynecuzick creation_date: 2018-10-19T13:43:13Z [Term] id: PHIPO:0000331 name: pathogen penetration into host present namespace: pathogen_host_interaction_phenotype def: "A pathogen entry into host phenotype in which pathogen penetration into the body, tissues, or cells of the host organism is present." [] synonym: "pathogen invasion of host present" RELATED [] is_a: PHIPO:0000949 ! pathogen entry into host phenotype created_by: alaynecuzick creation_date: 2018-10-29T15:59:22Z [Term] id: PHIPO:0000332 name: pathogen colonization of host phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the pathogen colonization of the body, tissues, or cells of the host organism." [] comment: Colonization of host is the action of a pathogen establishing itself in a host. (Covers adhesion, penetration, surface growth). is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2018-10-29T16:06:31Z [Term] id: PHIPO:0000333 name: pathogen cell to cell migration within host phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype which affects the directional movement of the pathogen within the host organism (GO:0044001)." [] is_a: PHIPO:0000332 ! pathogen colonization of host phenotype created_by: alaynecuzick creation_date: 2018-10-29T16:08:18Z [Term] id: PHIPO:0000334 name: abnormal pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the occurrence of the directional movement of the pathogen within the host organism is abnormal." [] is_a: PHIPO:0000333 ! pathogen cell to cell migration within host phenotype created_by: alaynecuzick creation_date: 2018-10-29T16:09:56Z [Term] id: PHIPO:0000335 name: normal pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the occurrence of the directional movement of the pathogen within the host organism is normal." [] is_a: PHIPO:0000333 ! pathogen cell to cell migration within host phenotype created_by: alaynecuzick creation_date: 2018-10-29T16:10:17Z [Term] id: PHIPO:0000336 name: obsolete intracellular growth phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-29T16:16:46Z [Term] id: PHIPO:0000337 name: obsolete extracellular growth phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-29T16:17:02Z [Term] id: PHIPO:0000338 name: increased pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the occurrence of the directional movement of the pathogen within the host organism is increased compared to normal." [] is_a: PHIPO:0000334 ! abnormal pathogen cell to cell migration within host created_by: alaynecuzick creation_date: 2018-10-29T16:17:55Z [Term] id: PHIPO:0000339 name: decreased pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the occurrence of the directional movement of the pathogen within the host organism is decreased compared to normal." [] is_a: PHIPO:0000334 ! abnormal pathogen cell to cell migration within host created_by: alaynecuzick creation_date: 2018-10-29T16:18:09Z [Term] id: PHIPO:0000340 name: abolished pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the ability of the pathogen to move directionally within the host organism is abolished (pathogen migration was present within the host and is now absent)." [] is_a: PHIPO:0000334 ! abnormal pathogen cell to cell migration within host created_by: alaynecuzick creation_date: 2018-10-29T16:18:22Z [Term] id: PHIPO:0000341 name: obsolete gain of pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the ability of the pathogen to move directionally within the host organism is gained (pathogen migration was absent within the host and is now present)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-29T16:18:44Z [Term] id: PHIPO:0000342 name: premature pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the occurrence of the directional movement of the pathogen within the host organism happens sooner than normal." [] is_a: PHIPO:0000334 ! abnormal pathogen cell to cell migration within host created_by: alaynecuzick creation_date: 2018-10-29T16:19:03Z [Term] id: PHIPO:0000343 name: delayed pathogen cell to cell migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the occurrence of the directional movement of the pathogen within the host organism happens later than normal." [] is_a: PHIPO:0000334 ! abnormal pathogen cell to cell migration within host created_by: alaynecuzick creation_date: 2018-10-29T16:19:20Z [Term] id: PHIPO:0000344 name: obsolete normal pathogen host interaction molecular function namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-29T16:23:29Z [Term] id: PHIPO:0000345 name: obsolete abnormal pathogen host interaction molecular function namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-29T16:32:47Z [Term] id: PHIPO:0000346 name: obsolete host necrotic lesion with pathogen phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-29T16:33:27Z [Term] id: PHIPO:0000347 name: pathogen host interaction molecular function phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects a molecular function such as binding or catalytic activity." [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2018-10-29T16:34:09Z [Term] id: PHIPO:0000348 name: obsolete pathogen host interaction catalytic activity phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects a catalytic activity." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-10-29T17:04:57Z [Term] id: PHIPO:0000349 name: presence of pathogen growth on host surface namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype where the vegetative growth or proliferation of the pathogen on the host surface is present." [] synonym: "pathogen growth present on host surface" EXACT [] is_a: PHIPO:0000188 ! pathogen growth on host surface phenotype created_by: alaynecuzick creation_date: 2018-11-05T13:23:08Z [Term] id: PHIPO:0000350 name: absence of pathogen growth on host surface namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype where the vegetative growth or proliferation of the pathogen on the host surface is absent." [] synonym: "pathogen growth absent on host surface" EXACT [] is_a: PHIPO:0000188 ! pathogen growth on host surface phenotype created_by: alaynecuzick creation_date: 2018-11-05T13:23:33Z [Term] id: PHIPO:0000351 name: obsolete pathogen is able to penetrate host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the pathogen is able to penetrate the host." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-11-05T13:24:13Z [Term] id: PHIPO:0000352 name: normal formation of pathogen penetration structure prior to entry into host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the formation of the pathogen penetration structure is normal (i.e indistinguishable from wild type)." [] synonym: "normal formation of pathogen infection structure prior to entry into host" EXACT [] synonym: "normal pre penetration of host by pathogen" EXACT [] is_a: PHIPO:0000949 ! pathogen entry into host phenotype created_by: alaynecuzick creation_date: 2018-11-05T13:24:42Z [Term] id: PHIPO:0000353 name: obsolete normal penetration of host by pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the pathogen penetration into the host is normal (i.e. indistinguishable from wild type)." [] synonym: "normal pathogen entry into host" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-11-05T13:25:01Z [Term] id: PHIPO:0000355 name: pathogen penetration into host absent namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000357 def: "A pathogen entry into host phenotype in which pathogen penetration into the body, tissues, or cells of the host organism is absent." [] synonym: "abolished pathogen entry into host" EXACT [] synonym: "abolished pathogen penetration into host" RELATED [] synonym: "pathogen invasion of host absent" RELATED [] is_a: PHIPO:0000949 ! pathogen entry into host phenotype created_by: alaynecuzick creation_date: 2018-11-05T13:26:18Z [Term] id: PHIPO:0000356 name: obsolete abnormal penetration of host by pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the pathogen penetration into the host is abnormal (i.e different than wild-type)." [] synonym: "abnormal pathogen entry into host phenotype" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-11-05T13:26:35Z [Term] id: PHIPO:0000358 name: obsolete non-functional pathogen penetration structure in contact with host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the pathogen forms a non-functional specialized penetration structure." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-11-05T13:30:29Z [Term] id: PHIPO:0000359 name: decreased pathogen penetration into host namespace: pathogen_host_interaction_phenotype def: "A pathogen entry into host phenotype in which the frequency of occurrence of pathogen penetration into the body, tissues, or cells of the host organism is decreased." [] synonym: "decreased pathogen entry into host" EXACT [] synonym: "decreased pathogen invasion of host" RELATED [] is_a: PHIPO:0000331 ! pathogen penetration into host present created_by: alaynecuzick creation_date: 2018-11-05T13:31:26Z [Term] id: PHIPO:0000360 name: increased pathogen penetration into host namespace: pathogen_host_interaction_phenotype def: "A pathogen entry into host phenotype in which the frequency of occurrence of pathogen penetration into the body, tissues, or cells of the host organism is increased." [] synonym: "increased pathogen entry into host" EXACT [] synonym: "increased pathogen invasion of host" RELATED [] is_a: PHIPO:0000331 ! pathogen penetration into host present created_by: alaynecuzick creation_date: 2018-11-05T13:32:32Z [Term] id: PHIPO:0000361 name: delayed pathogen penetration into host namespace: pathogen_host_interaction_phenotype def: "A pathogen entry into host phenotype in which the frequency of occurrence of pathogen penetration into the body, tissues, or cells of the host organism begins later than normal." [] synonym: "delayed pathogen entry into host" EXACT [] synonym: "delayed pathogen invasion of host" RELATED [] is_a: PHIPO:0000331 ! pathogen penetration into host present created_by: alaynecuzick creation_date: 2018-11-05T13:32:57Z [Term] id: PHIPO:0000362 name: premature pathogen penetration into host namespace: pathogen_host_interaction_phenotype def: "A pathogen entry into host phenotype in which the frequency of occurrence of pathogen penetration into the body, tissues, or cells of the host organism begins sooner than normal." [] synonym: "premature pathogen entry into host" EXACT [] synonym: "premature pathogen invasion of host" RELATED [] is_a: PHIPO:0000331 ! pathogen penetration into host present created_by: alaynecuzick creation_date: 2018-11-05T13:33:34Z [Term] id: PHIPO:0000363 name: absence of pathogen growth within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype in which the vegetative growth or proliferation of the pathogen inside the host is absent." [] synonym: "absent pathogen growth within host" EXACT [] is_a: PHIPO:0000951 ! pathogen growth within host phenotype created_by: alaynecuzick creation_date: 2018-11-05T13:35:05Z [Term] id: PHIPO:0000364 name: obsolete abnormal pathogen growth within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype in which the vegetative growth or proliferation of the pathogen inside the host is abnormal (i.e different than wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-11-05T13:37:31Z [Term] id: PHIPO:0000365 name: decreased pathogen growth within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype in which the frequency of occurrence of vegetative growth or proliferation of the pathogen inside the host is decreased." [] synonym: "decreased branching of invasive hyphae in host" NARROW [] synonym: "decreased number of invasive hyphae in host" NARROW [] synonym: "reduced pathogen biomass within host tissue" RELATED [] is_a: PHIPO:0000954 ! presence of pathogen growth within host created_by: alaynecuzick creation_date: 2018-11-05T13:39:00Z [Term] id: PHIPO:0000366 name: delayed timing of pathogen growth within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype in which the frequency of occurrence of vegetative growth or proliferation of the pathogen inside the host begins later than normal." [] is_a: PHIPO:0000954 ! presence of pathogen growth within host created_by: alaynecuzick creation_date: 2018-11-05T13:39:34Z [Term] id: PHIPO:0000367 name: premature pathogen growth within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype in which the frequency of occurrence of vegetative growth or proliferation of the pathogen inside the host begins sooner than normal." [] is_a: PHIPO:0000954 ! presence of pathogen growth within host created_by: alaynecuzick creation_date: 2018-11-05T13:40:14Z [Term] id: PHIPO:0000368 name: increased pathogen growth within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype in which the frequency of occurrence of vegetative growth or proliferation of the pathogen inside the host is increased." [] synonym: "increased pathogen biomass within host tissue" RELATED [] is_a: PHIPO:0000954 ! presence of pathogen growth within host created_by: alaynecuzick creation_date: 2018-11-05T13:41:05Z [Term] id: PHIPO:0000369 name: abnormal formation of pathogen penetration structure when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the formation of the pathogen penetration structure is abnormal (i.e different than wild-type)." [] synonym: "abnormal formation of pathogen infection structure when near host" EXACT [] synonym: "abnormal pre penetration" EXACT [] is_a: PHIPO:0000949 ! pathogen entry into host phenotype created_by: alaynecuzick creation_date: 2018-11-08T12:12:18Z [Term] id: PHIPO:0000370 name: obsolete pathogen penetration structure absent when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the pathogen specialized host penetration structure is absent." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-11-08T12:14:10Z [Term] id: PHIPO:0000371 name: decreased number of pathogen penetration structure when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the frequency of occurrence of pathogen penetration stuctures near the host are decreased." [] synonym: "decreased number of pathogen infection structure when near host" EXACT [] is_a: PHIPO:0000369 ! abnormal formation of pathogen penetration structure when near host created_by: alaynecuzick creation_date: 2018-11-08T12:15:52Z [Term] id: PHIPO:0000372 name: decreased size of pathogen penetration structure when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the size of pathogen penetration stuctures near the host are decreased." [] synonym: "decreased size of pathogen infection structure when near host" EXACT [] is_a: PHIPO:0000369 ! abnormal formation of pathogen penetration structure when near host created_by: alaynecuzick creation_date: 2018-11-08T12:16:29Z [Term] id: PHIPO:0000373 name: increased number of pathogen penetration structure when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the frequency of occurrence of pathogen penetration stuctures near the host are increased." [] synonym: "increased number of pathogen infection structure when near host" EXACT [] is_a: PHIPO:0000369 ! abnormal formation of pathogen penetration structure when near host created_by: alaynecuzick creation_date: 2018-11-08T12:16:46Z [Term] id: PHIPO:0000374 name: increased size of pathogen penetration structure when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the size of pathogen penetration stuctures near the host are increased." [] synonym: "increased size of pathogen infection structure when near host" EXACT [] is_a: PHIPO:0000369 ! abnormal formation of pathogen penetration structure when near host created_by: alaynecuzick creation_date: 2018-11-08T12:17:03Z [Term] id: PHIPO:0000375 name: delayed timing of pathogen penetration structure formation when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the formation of pathogen specialized penetration structure begins later than normal." [] synonym: "delayed timing of pathogen infection structure formation when near host" EXACT [] is_a: PHIPO:0000369 ! abnormal formation of pathogen penetration structure when near host created_by: alaynecuzick creation_date: 2018-11-08T12:17:35Z [Term] id: PHIPO:0000376 name: premature pathogen penetration structure formation when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the formation of pathogen specialized penetration structure begins sooner than normal." [] synonym: "premature pathogen infection structure formation when near host" EXACT [] is_a: PHIPO:0000369 ! abnormal formation of pathogen penetration structure when near host created_by: alaynecuzick creation_date: 2018-11-08T12:17:52Z [Term] id: PHIPO:0000377 name: resistance to carboxin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to carboxin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:32:23Z [Term] id: PHIPO:0000378 name: sensitive to carboxin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to carboxin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:33:05Z [Term] id: PHIPO:0000379 name: abnormal cell wall organization namespace: single_species_phenotype def: "A cellular process phenotype in which cell wall organization is abnormal. Cell wall organization results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [] xref: FYPO:0004805 is_a: PHIPO:0000400 ! abnormal cellular component organization created_by: alaynecuzick creation_date: 2018-12-05T11:33:32Z [Term] id: PHIPO:0000380 name: normal transporter activity namespace: single_species_phenotype def: "A molecular function phenotype in which the observed rate of a specified transporter activity is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0002115 is_a: PHIPO:0000409 ! transporter activity phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:33:53Z [Term] id: PHIPO:0000381 name: resistance to benomyl namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to benomyl. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:34:42Z [Term] id: PHIPO:0000382 name: resistance to diethofencarb namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to diethofencarb. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:35:13Z [Term] id: PHIPO:0000383 name: resistance to carbendazim namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to carbendazim. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:35:34Z [Term] id: PHIPO:0000384 name: resistance to thiophanate methyl namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to thiophanate methyl. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:35:57Z [Term] id: PHIPO:0000385 name: resistance to oxolinic acid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to oxolinic acid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:36:23Z [Term] id: PHIPO:0000386 name: resistance to naftifine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to naftifine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:37:06Z [Term] id: PHIPO:0000387 name: resistance to terbinafine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to terbinafine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:37:20Z [Term] id: PHIPO:0000388 name: resistance to azoxystrobin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to azoxystrobin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000576 ! resistance to strobilurin A created_by: alaynecuzick creation_date: 2018-12-05T11:37:46Z [Term] id: PHIPO:0000389 name: resistance to iprodione namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to iprodione. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:38:07Z [Term] id: PHIPO:0000390 name: sensitive to diethofencarb namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to diethocarb. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:39:03Z [Term] id: PHIPO:0000391 name: sensitive to carbendazim namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to carbendazim. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:39:31Z [Term] id: PHIPO:0000392 name: sensitive to thiophanate methyl namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to thiophanate methyl. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:39:58Z [Term] id: PHIPO:0000393 name: sensitive to oxolinic acid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to oxolinic acid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:40:15Z [Term] id: PHIPO:0000394 name: sensitive to naftifine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to naftifine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:40:34Z [Term] id: PHIPO:0000395 name: sensitive to terbinafine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to terbinafine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:40:53Z [Term] id: PHIPO:0000396 name: sensitive to azoxystrobin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to azoxystrobin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000804 ! sensitive to strobilurin A created_by: alaynecuzick creation_date: 2018-12-05T11:41:17Z [Term] id: PHIPO:0000397 name: sensitive to iprodione namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to iprodione. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:41:35Z [Term] id: PHIPO:0000398 name: sensitive to benomyl namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to benomyl. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2018-12-05T11:42:11Z [Term] id: PHIPO:0000399 name: obsolete abnormal phialide morphology namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-05T11:43:18Z [Term] id: PHIPO:0000400 name: abnormal cellular component organization namespace: single_species_phenotype def: "A cellular process phenotype in which any process of cellular component organization at the cellular level is abnormal." [] xref: FYPO:0000335 is_a: PHIPO:0000407 ! cellular component organization phenotype is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-12-05T11:43:39Z [Term] id: PHIPO:0000401 name: obsolete normal phialide morphology namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-05T11:43:53Z [Term] id: PHIPO:0000402 name: individual organism phenotype namespace: single_species_phenotype def: "A single species phenotype that is observed at the level of an individual organism." [] is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:44:12Z [Term] id: PHIPO:0000403 name: normal cell phenotype namespace: single_species_phenotype def: "A phenotype that does not show any detectable differences from normal at the level of an individual cell." [] is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:44:26Z [Term] id: PHIPO:0000404 name: abnormal cell phenotype namespace: single_species_phenotype def: "A phenotype that shows detectable differences from normal at the level of an individual cell." [] xref: FYPO:0003037 is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:44:40Z [Term] id: PHIPO:0000405 name: normal unicellular population growth namespace: single_species_phenotype alt_id: PHIPO:0000123 def: "A single species population growth phenotype where the rate or extent of the increase in the number of unicellular organisms in the population (i.e organismal growth and reproduction) is normal (i.e. indistinguishable from wild type)." [] synonym: "normal population growth during dimorphic yeast-form" RELATED [] is_a: PHIPO:0000162 ! unicellular population growth phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:44:58Z [Term] id: PHIPO:0000406 name: nucleus absent namespace: single_species_phenotype def: "A single organism phenotype in which the nucleus is absent." [] is_a: PHIPO:0000934 ! abnormal nucleus created_by: alaynecuzick creation_date: 2018-12-05T11:45:18Z [Term] id: PHIPO:0000407 name: cellular component organization phenotype namespace: single_species_phenotype def: "A phenotype that affects a process of cellular component organization, i.e. the assembly, arrangement of constituent parts, or disassembly of a cellular component, that occurs at the cellular level." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cellular component organisation phenotype" EXACT [] xref: FYPO:0000334 is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:45:32Z [Term] id: PHIPO:0000408 name: obsolete morphology phenotype namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-05T11:46:07Z [Term] id: PHIPO:0000409 name: transporter activity phenotype namespace: single_species_phenotype def: "A phenotype that affects a transporter activity." [] xref: FYPO:0002114 is_a: PHIPO:0000411 ! molecular function phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:46:27Z [Term] id: PHIPO:0000410 name: decreased asexual spore germination frequency namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spore germination is decreased." [] synonym: "decreased conidia germination frequency" EXACT [] is_a: PHIPO:0000509 ! population phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:46:43Z [Term] id: PHIPO:0000411 name: molecular function phenotype namespace: single_species_phenotype def: "A phenotype that affects a molecular function such as binding or catalytic activity." [] is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:46:59Z [Term] id: PHIPO:0000413 name: abnormal molecular function namespace: single_species_phenotype def: "A phenotype in which a specific molecular function is abnormal." [] xref: FYPO:0000707 is_a: PHIPO:0000411 ! molecular function phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:47:25Z [Term] id: PHIPO:0000414 name: abnormal unicellular population growth namespace: single_species_phenotype alt_id: PHIPO:0000163 def: "A single species population growth phenotype where the rate or extent of the increase in the number of unicellular organisms in the population (i.e organismal growth and reproduction) is lesser or greater than normal." [] synonym: "abnormal population growth during dimorphic yeast-form" RELATED [] is_a: PHIPO:0000162 ! unicellular population growth phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:47:39Z [Term] id: PHIPO:0000415 name: abnormal subcellular component namespace: single_species_phenotype def: "A single organism phenotype in which the amount, distribution, composition or morphology of a cell part is abnormal." [] xref: FYPO:0000287 is_a: PHIPO:0000463 ! subcellular component phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:47:55Z [Term] id: PHIPO:0000416 name: normal molecular function namespace: single_species_phenotype def: "A phenotype in which a specific molecular function is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0000706 is_a: PHIPO:0000411 ! molecular function phenotype created_by: alaynecuzick creation_date: 2018-12-05T11:48:08Z [Term] id: PHIPO:0000417 name: obsolete abnormal pathogen host interaction pathogen carbohydrate binding phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-10T14:12:15Z [Term] id: PHIPO:0000418 name: normal carbohydrate binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which occurrence of carbohydrate binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [] is_a: PHIPO:0000430 ! carbohydrate binding phenotype created_by: alaynecuzick creation_date: 2018-12-10T14:12:55Z [Term] id: PHIPO:0000419 name: abnormal carbohydrate binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which occurrence of carbohydrate binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [] is_a: PHIPO:0000413 ! abnormal molecular function is_a: PHIPO:0000430 ! carbohydrate binding phenotype created_by: alaynecuzick creation_date: 2018-12-10T14:13:02Z [Term] id: PHIPO:0000420 name: normal pathogen chitin fragment binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which occurrence of pathogen chitin fragment binding by a pathogen gene product is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0000418 ! normal carbohydrate binding created_by: alaynecuzick creation_date: 2018-12-10T14:14:16Z [Term] id: PHIPO:0000421 name: abolished carbohydrate binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which carbohydrate binding by a gene product does not occur, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] is_a: PHIPO:0000419 ! abnormal carbohydrate binding created_by: alaynecuzick creation_date: 2018-12-10T14:16:24Z [Term] id: PHIPO:0000422 name: altered carbohydrate binding specificity namespace: single_species_phenotype def: "A single species phenotype in which a gene product that normally binds to a specific carbohydrate instead binds to a different carbohydrate when a gene is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [] comment: no logical definition for 'altered ? binding specificity' in FYPO is_a: PHIPO:0000419 ! abnormal carbohydrate binding created_by: alaynecuzick creation_date: 2018-12-10T14:17:21Z [Term] id: PHIPO:0000423 name: decreased carbohydrate binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which occurrence of carbohydrate binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [] is_a: PHIPO:0000419 ! abnormal carbohydrate binding created_by: alaynecuzick creation_date: 2018-12-10T14:17:46Z [Term] id: PHIPO:0000424 name: increased carbohydrate binding namespace: single_species_phenotype def: "A single species molecular function phenotype in which occurrence of carbohydrate binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [] is_a: PHIPO:0000419 ! abnormal carbohydrate binding created_by: alaynecuzick creation_date: 2018-12-10T14:18:04Z [Term] id: PHIPO:0000425 name: obsolete pathogen host interaction pathogen carbohydrate binding phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the binding of carbohydrate to protein." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-10T14:23:58Z [Term] id: PHIPO:0000426 name: obsolete presence of pathogen chitinase binding to pathogen chitin fragments within host interaction namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of pathogen chitinase to pathogen chitin fragments generated within a host interaction is present." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-10T14:30:09Z [Term] id: PHIPO:0000427 name: obsolete pathogen chitin binding to host chitinase present namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of pathogen chitin to host chitinase is present." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-10T14:31:18Z [Term] id: PHIPO:0000428 name: obsolete normal pathogen host interaction pathogen carbohydrate binding phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-10T14:32:15Z [Term] id: PHIPO:0000429 name: obsolete normal pathogen and host chitinases bind pathogen chitin and chitin fragments namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-10T14:32:50Z [Term] id: PHIPO:0000430 name: carbohydrate binding phenotype namespace: single_species_phenotype def: "A single species molecular function phenotype that affects carbohydrate binding. The affected gene product may be encoded by the mutated gene, or by a different gene." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000158 ! binding phenotype created_by: alaynecuzick creation_date: 2018-12-10T14:37:34Z [Term] id: PHIPO:0000431 name: abolished pathogen chitin fragment binding namespace: single_species_phenotype def: "A single species pathogen molecular function phenotype in which pathogen chitin fragment binding by a pathogen gene product does not occur. (It was present and is now absent)." [] is_a: PHIPO:0000421 ! abolished carbohydrate binding created_by: alaynecuzick creation_date: 2018-12-10T14:39:51Z [Term] id: PHIPO:0000432 name: catalytic activity phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects a catalytic activity." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000654 is_a: PHIPO:0000411 ! molecular function phenotype created_by: alaynecuzick creation_date: 2018-12-11T13:52:59Z [Term] id: PHIPO:0000433 name: normal catalytic activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the observed rate and other catalytic properties of a specified catalytic activity are normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0000660 is_a: PHIPO:0000432 ! catalytic activity phenotype created_by: alaynecuzick creation_date: 2018-12-11T13:54:41Z [Term] id: PHIPO:0000434 name: abnormal catalytic activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the observed rate or other catalytic property of a specified catalytic activity is abnormal." [] xref: FYPO:0000661 is_a: PHIPO:0000413 ! abnormal molecular function is_a: PHIPO:0000432 ! catalytic activity phenotype created_by: alaynecuzick creation_date: 2018-12-11T13:55:08Z [Term] id: PHIPO:0000435 name: abolished catalytic activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which a specified catalytic activity is absent." [] synonym: "catalytic activity abolished" EXACT [] synonym: "catalytic activity absent" EXACT [] xref: FYPO:0000664 is_a: PHIPO:0000434 ! abnormal catalytic activity created_by: alaynecuzick creation_date: 2018-12-12T14:40:37Z [Term] id: PHIPO:0000436 name: decreased catalytic activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the observed rate of a specified catalytic activity is decreased." [] xref: FYPO:0000663 is_a: PHIPO:0000434 ! abnormal catalytic activity created_by: alaynecuzick creation_date: 2018-12-12T14:40:59Z [Term] id: PHIPO:0000437 name: increased catalytic activity namespace: single_species_phenotype alt_id: PHIPO:0001082 def: "A single species molecular function phenotype in which the observed rate of a specified catalytic activity is increased." [] synonym: "gain of catalytic activity" RELATED [] xref: FYPO:0000662 is_a: PHIPO:0000434 ! abnormal catalytic activity created_by: alaynecuzick creation_date: 2018-12-12T14:41:15Z [Term] id: PHIPO:0000438 name: altered substrate specificity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the substrate specificity of a catalytic activity differs from wild type." [] comment: no FYPO logical defintion for 'altered substrate specificity' xref: FYPO:0003347 is_a: PHIPO:0000434 ! abnormal catalytic activity created_by: alaynecuzick creation_date: 2018-12-12T14:41:30Z [Term] id: PHIPO:0000439 name: pathogen reproductive phenotype within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the pathogen reproductive process within the host. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms (GO:0000003)." [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2018-12-18T11:25:46Z [Term] id: PHIPO:0000440 name: normal pathogen reproductive phenotype within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the pathogen reproductive process within the host is normal (indistinguishable from wild type)." [] is_a: PHIPO:0000439 ! pathogen reproductive phenotype within host created_by: alaynecuzick creation_date: 2018-12-18T11:26:40Z [Term] id: PHIPO:0000441 name: abnormal pathogen reproductive phenotype within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the pathogen reproductive process within the host is abnormal." [] is_a: PHIPO:0000439 ! pathogen reproductive phenotype within host created_by: alaynecuzick creation_date: 2018-12-18T11:26:59Z [Term] id: PHIPO:0000442 name: normal pathogen asexual reproduction within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host where the pathogen asexual reproduction process, in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process is normal (indistinguishable from wild type)(GO:0019954)." [] is_a: PHIPO:0000440 ! normal pathogen reproductive phenotype within host created_by: alaynecuzick creation_date: 2018-12-18T11:27:55Z [Term] id: PHIPO:0000443 name: normal pathogen sexual reproduction within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host where the pathogen sexual reproduction process, in which new individuals are produced by combining the genetic material of two gametes, which may come from two organisms or from a single organism is normal (indistinguishable from wild type) (GO:0019953)." [] is_a: PHIPO:0000440 ! normal pathogen reproductive phenotype within host created_by: alaynecuzick creation_date: 2018-12-18T11:28:13Z [Term] id: PHIPO:0000444 name: decreased number of asexual pathogen spores within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of asexual spores is decreased." [] synonym: "decreased number of pathogen conidia within host" EXACT [] synonym: "decreased number of pathogen uredinia within host" EXACT [] is_a: PHIPO:0000448 ! abnormal number of asexual pathogen spores within host created_by: alaynecuzick creation_date: 2018-12-18T11:34:08Z [Term] id: PHIPO:0000445 name: pathogen host interaction host lesion formation phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype that affects the process of host tissue death causing a host lesion induced by either the pathogen directly killing host tissue (e.g. cell wall degradation), or the host activating its own cell death pathways in defense." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "host necrotic lesion with pathogen phenotype" EXACT [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2018-12-18T12:46:14Z [Term] id: PHIPO:0000446 name: host cell death phenotype namespace: single_species_phenotype def: "A single species phenotype that affects the cell death within a host." [] subset: host_phenotype is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2018-12-18T12:46:45Z [Term] id: PHIPO:0000447 name: increased number of asexual pathogen spores within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of asexual spores is increased." [] synonym: "increased number of pathogen conidia within host" EXACT [] synonym: "increased number of pathogen uredinia within host" EXACT [] is_a: PHIPO:0000448 ! abnormal number of asexual pathogen spores within host created_by: alaynecuzick creation_date: 2018-12-18T13:53:43Z [Term] id: PHIPO:0000448 name: abnormal number of asexual pathogen spores within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of asexual spores is abnormal" [] synonym: "abnormal number of pathogen conidia within host" EXACT [] is_a: PHIPO:0000449 ! abnormal pathogen asexual reproduction within host created_by: alaynecuzick creation_date: 2018-12-18T14:43:36Z [Term] id: PHIPO:0000449 name: abnormal pathogen asexual reproduction within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host where the pathogen asexual reproduction process, in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process is abnormal (GO:0019954)." [] is_a: PHIPO:0000469 ! abnormal pathogen asexual sporulation within host created_by: alaynecuzick creation_date: 2018-12-18T14:44:36Z [Term] id: PHIPO:0000450 name: normal pathogen peptidase activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the observed rate of a peptidase activity is normal (i.e. indistinguishable from wild type)." [] synonym: "normal protease activity" EXACT [] xref: FYPO:0000665 is_a: PHIPO:0000433 ! normal catalytic activity created_by: alaynecuzick creation_date: 2018-12-19T09:51:47Z [Term] id: PHIPO:0000461 name: presence of pathogen-associated host defense induced lesions namespace: pathogen_host_interaction_phenotype def: "A phenotype where the process of host tissue cell death causing a host lesion is induced by the host activating its own programmed cell death pathways in defense, is present." [] comment: Note that if you are curating a necrotroph you need to annotate to PHIPO:0000477. synonym: "host necrotic cell death" RELATED [] synonym: "host programmed cell death phenotype induced by pathogen presence" RELATED [] synonym: "presence of host lesion" RELATED [] is_a: PHIPO:0000480 ! presence of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2018-12-21T12:55:04Z [Term] id: PHIPO:0000463 name: subcellular component phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the subcellular components in a cell." [] is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2018-12-21T12:56:41Z [Term] id: PHIPO:0000464 name: obsolete host necrotic cell death phenotype in response to pathogen namespace: pathogen_host_interaction_phenotype def: "A phenotype affecting the process of host tissue cell death caused by the pathogen (GO:0097300 part of GO:0009608 )." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-21T13:01:44Z [Term] id: PHIPO:0000465 name: absence of pathogen necrotrophic effector-mediated host programmed cell death namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000462 def: "A phenotype where the process of a necrotrophic pathogen effector activating the host immune system to trigger programmed cell death is absent." [] comment: This term is to be used when the pathogen actively induces the host responses, not for host protection against the pathogen. An effector is an entity derived from a pathogenic or non-pathogenic species that either activates or suppresses host defenses or other host responses. synonym: "abolished effector-mediated host programmed cell death during necrotrophy" RELATED [] synonym: "abolished host lesion" RELATED [] synonym: "abolished host necrotic cell death" RELATED [] synonym: "absence of effector-mediated host programmed cell death during necrotrophy" RELATED [] synonym: "absence of host lesion" RELATED [] synonym: "absence of host necrotic cell death" RELATED [] is_a: PHIPO:0000280 ! pathogen effector mediated modulation of host immune system process is_a: PHIPO:0000481 ! absence of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2018-12-21T12:55:59Z [Term] id: PHIPO:0000466 name: obsolete host necrotic cell death by pathogen induced hypersensitive response namespace: pathogen_host_interaction_phenotype def: "A phenotype that affects the immune system process of host necrotic cell death by pathogen induced hypersensitive response. Pathogen induced hypersensitive response is the rapid, localized death of plant cells in response to invasion by a pathogen (GO:0009626)." [] comment: This term is to be used for host protection against the pathogen. This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2018-12-21T13:09:35Z [Term] id: PHIPO:0000467 name: presence of effector-independent host hypersensitive response namespace: single_species_phenotype def: "A single species phenotype where the immune system process of host tissue hypersensitive response is present in a pathogen effector-independant manner. (i.e. an alteration within the host is responsible for the activation of the hypersensitive response in the absence of a pathogen)." [] subset: host_phenotype is_a: PHIPO:0000446 ! host cell death phenotype is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2018-12-21T13:24:37Z [Term] id: PHIPO:0000468 name: absence of pathogen asexual spores within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host where the pathogen asexual spores are absent (FAO:0000023)." [] synonym: "pathogen conidia absent within host" EXACT [] synonym: "pathogen uredinia absent within host" EXACT [] is_a: PHIPO:0000469 ! abnormal pathogen asexual sporulation within host created_by: alaynecuzick creation_date: 2019-01-11T10:31:18Z [Term] id: PHIPO:0000469 name: abnormal pathogen asexual sporulation within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host where the process of pathogen asexual sporulation, the formation of spores derived from the products of an asexual cell division, is abnormal (GO:0030436)." [] is_a: PHIPO:0000441 ! abnormal pathogen reproductive phenotype within host created_by: alaynecuzick creation_date: 2019-01-11T10:32:18Z [Term] id: PHIPO:0000470 name: obsolete location of pathogen growth within host phenotype namespace: pathogen_host_interaction_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-11T10:40:06Z [Term] id: PHIPO:0000472 name: normal pathogen asexual sporulation within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host where the process of pathogen asexual sporulation, the formation of spores derived from the products of an asexual cell division, is normal (GO:0030436)." [] is_a: PHIPO:0000442 ! normal pathogen asexual reproduction within host created_by: alaynecuzick creation_date: 2019-01-11T11:49:51Z [Term] id: PHIPO:0000473 name: presence of pathogen asexual spores within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of asexual spores is normal (i.e. indistinguishable from wild type)." [] synonym: "normal number of pathogen conidia within host" EXACT [] synonym: "normal number of pathogen uredinia within host" EXACT [] is_a: PHIPO:0000472 ! normal pathogen asexual sporulation within host created_by: alaynecuzick creation_date: 2019-01-11T11:55:09Z [Term] id: PHIPO:0000474 name: abnormal number of lipid droplets namespace: single_species_phenotype def: "A single species phenotype observed in the vegetative growth phase of the life cycle in which cells contain a different number of lipid droplets than normal." [] is_a: PHIPO:0000478 ! lipid droplet phenotype created_by: alaynecuzick creation_date: 2019-01-14T12:21:01Z [Term] id: PHIPO:0000475 name: decreased size of lipid droplet namespace: single_species_phenotype def: "A single organism phenotype observed in the vegetative growth phase of the life cycle in which the size of lipid droplets is decreased." [] is_a: PHIPO:0000036 ! abnormal lipid droplet morphology created_by: alaynecuzick creation_date: 2019-01-14T12:21:13Z [Term] id: PHIPO:0000477 name: presence of pathogen necrotrophic effector-mediated host programmed cell death namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000476 def: "A phenotype where the process of a necrotrophic pathogen effector activating the host immune system to trigger programmed cell death is present." [] comment: This term is to be used when the pathogen actively induces the host responses, not for host protection against the pathogen. An effector is an entity derived from a pathogenic or non-pathogenic species that either activates or suppresses host defenses or other host responses. synonym: "gain of effector-mediated host programmed cell death during necrotrophy" RELATED [] synonym: "gain of host necrotic cell death" RELATED [] synonym: "gain of presence of host lesion" RELATED [] synonym: "presence of effector-mediated host programmed cell death during necrotrophy" RELATED [] synonym: "presence of host lesion" RELATED [] synonym: "presence of host necrotic cell death" RELATED [] is_a: PHIPO:0000280 ! pathogen effector mediated modulation of host immune system process is_a: PHIPO:0000480 ! presence of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2019-01-14T12:22:36Z [Term] id: PHIPO:0000478 name: lipid droplet phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects an intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [] xref: GO:0005811 is_a: PHIPO:0000415 ! abnormal subcellular component created_by: alaynecuzick creation_date: 2019-01-14T12:23:44Z [Term] id: PHIPO:0000479 name: increased size of lipid droplet namespace: single_species_phenotype def: "A single organism phenotype observed in the vegetative growth phase of the life cycle in which the size of lipid droplets is increased." [] is_a: PHIPO:0000036 ! abnormal lipid droplet morphology created_by: alaynecuzick creation_date: 2019-01-14T12:23:54Z [Term] id: PHIPO:0000480 name: presence of pathogen-associated host lesions namespace: pathogen_host_interaction_phenotype def: "A phenotype where the process of host tissue cell death causing a host lesion is present." [] comment: The lesion can be induced by either the pathogen directly killing host tissue (e.g. cell wall degradation), or the host activating its own cell death pathways in defense. synonym: "normal host lesion formation with pathogen" EXACT [] synonym: "presence of host necrotic cell death by pathogen" RELATED [] is_a: PHIPO:0000445 ! pathogen host interaction host lesion formation phenotype created_by: alaynecuzick creation_date: 2019-01-14T12:24:50Z [Term] id: PHIPO:0000481 name: absence of pathogen-associated host lesions namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000997 def: "A phenotype where the process of host tissue cell death causing a host lesion is absent." [] comment: The lesion can be induced by either the pathogen directly killing host tissue (e.g. cell wall degradation), or the host activating its own cell death pathways in defense. Note that if you are curating a necrotroph you need to annotate to PHIPO:0000465. synonym: "abolished pathogen-associated host lesions" RELATED [] synonym: "absence of host necrotic cell death by pathogen" RELATED [] is_a: PHIPO:0000445 ! pathogen host interaction host lesion formation phenotype created_by: alaynecuzick creation_date: 2019-08-10T13:35:33Z [Term] id: PHIPO:0000483 name: obsolete normal pathogen host interaction phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which is normal (i.e. the same as wild-type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-14T13:59:00Z [Term] id: PHIPO:0000484 name: obsolete abnormal pathogen host interaction phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which is abnormal (i.e. different than wild-type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-14T13:59:26Z [Term] id: PHIPO:0000492 name: metabolic process phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [] comment: Definition adapted from GO_0008152 metabolic process xref: GO_0008152 is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2019-01-18T12:52:27Z [Term] id: PHIPO:0000493 name: primary metabolic process phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [] comment: Definition adapted from GO:0044238 primary metabolic process xref: GO:0044238 is_a: PHIPO:0000492 ! metabolic process phenotype created_by: alaynecuzick creation_date: 2019-01-18T12:55:03Z [Term] id: PHIPO:0000494 name: secondary metabolic process phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [] comment: Definition adapted from GO:0019748 secondary metabolic process xref: GO:0019748 is_a: PHIPO:0000492 ! metabolic process phenotype created_by: alaynecuzick creation_date: 2019-01-18T12:55:20Z [Term] id: PHIPO:0000495 name: secondary metabolite biosynthetic process phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [] comment: Definition adapted from GO:0044550 secondary metabolite biosynthetic process xref: GO:0044550 is_a: PHIPO:0000494 ! secondary metabolic process phenotype created_by: alaynecuzick creation_date: 2019-01-18T13:02:07Z [Term] id: PHIPO:0000496 name: toxin biosynthetic process phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [] comment: Definition adapted fromo GO:0009403 toxin biosynthetic process xref: GO:0009403 is_a: PHIPO:0000495 ! secondary metabolite biosynthetic process phenotype created_by: alaynecuzick creation_date: 2019-01-18T13:04:12Z [Term] id: PHIPO:0000497 name: normal toxin biosynthetic process namespace: single_species_phenotype def: "A single organism phenotype in which the toxin biosynthetic process is normal (i.e. same as the wild type)." [] is_a: PHIPO:0000403 ! normal cell phenotype is_a: PHIPO:0000496 ! toxin biosynthetic process phenotype created_by: alaynecuzick creation_date: 2019-01-18T13:04:39Z [Term] id: PHIPO:0000498 name: abnormal toxin biosynthetic process namespace: single_species_phenotype def: "A single organism phenotype in which the toxin biosynthetic process is abnormal (i.e. different than the wild type)." [] comment: For logical defintions Do we want to make this species neutral and just add in DON at lowest child level and use CHEBI id CHEBI_10022 ## vomitoxin OR use fungi specific GO term GO_0106110 ## vomitoxin biosynthetic process?? is_a: PHIPO:0000496 ! toxin biosynthetic process phenotype is_a: PHIPO:0001147 ! cellular metabolic process phenotype created_by: alaynecuzick creation_date: 2019-01-18T13:04:53Z [Term] id: PHIPO:0000499 name: obsolete normal synthesis of deoxynivalenol namespace: single_species_phenotype def: "A single organism phenotype in which the biosynthesis of deoxynivalenol is normal (i.e. same as the wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-18T13:05:54Z [Term] id: PHIPO:0000500 name: obsolete abnormal biosynthesis of deoxynivalenol namespace: single_species_phenotype def: "A single organism phenotype in which the biosynthesis of deoxynivalenol is abnormal (i.e. different than the wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-18T13:06:19Z [Term] id: PHIPO:0000501 name: obsolete increased level of deoxynivalenol namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of deoxynivalenol measured in a cell is higher than normal." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-18T13:06:49Z [Term] id: PHIPO:0000502 name: obsolete decreased level of deoxynivalenol namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of deoxynivalenol measured in a cell is lower than normal." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-18T13:07:24Z [Term] id: PHIPO:0000503 name: obsolete deoxynivalenol absent from cell namespace: single_species_phenotype def: "A single organism cell phenotype in which the amount of deoxynivalenol measured in a cell is too low to detect." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-18T13:07:42Z [Term] id: PHIPO:0000504 name: obsolete deoxynivalenol present namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of deoxynivalenol measured in a cell is normal (i.e. indistinguishable from wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-18T13:07:54Z [Term] id: PHIPO:0000505 name: phenotype namespace: phipo def: "Any of the set of observable characteristics of an organism resulting from the interaction of its genotype with the environment." [] comment: Definition from FYPO. Unclear which namespace to enter under so currently 'floating' xref: FYPO:0000001 created_by: alaynecuzick creation_date: 2019-01-23T11:11:47Z [Term] id: PHIPO:0000506 name: obsolete single species namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-23T11:16:14Z [Term] id: PHIPO:0000507 name: obsolete pathogen host interaction namespace: pathogen_host_interaction_phenotype subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2019-01-23T13:11:21Z [Term] id: PHIPO:0000509 name: population phenotype namespace: single_species_phenotype def: "A single species phenotype that is observed at the level of a population." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note: differentium is population level, and may reflect observation conditions. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2019-02-11T12:07:38Z [Term] id: PHIPO:0000510 name: pathogen host interaction cell phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that is observed at the level of an individual cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000002 is_a: PHIPO:0000001 ! pathogen host interaction phenotype property_value: created:by "alaynecuzick" xsd:string creation_date: 2019-02-11T12:19:47Z [Term] id: PHIPO:0000511 name: obsolete pathogen host interaction cell population phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that is observed at the level of a population of cells." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note: differentium is population level, and may reflect observation conditions. no logical definition in FYPO subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000003 is_obsolete: true created_by: alaynecuzick creation_date: 2019-02-11T12:28:03Z [Term] id: PHIPO:0000512 name: obsolete pathogen host interaction host tissue phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that is observed at the level of a host tissue (eg leaf, inflorescence, ear or kidney)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate property_value: created:by "alaynecuzick" xsd:string is_obsolete: true creation_date: 2019-02-11T12:41:00Z [Term] id: PHIPO:0000513 name: inviable population namespace: single_species_phenotype def: "An organism population phenotype in which no organisms in the population are viable." [] synonym: "essential" RELATED [] synonym: "lethal" RELATED [] is_a: PHIPO:0000514 ! population viability phenotype property_value: created:by "alaynecuzick" xsd:string creation_date: 2019-02-11T13:01:17Z [Term] id: PHIPO:0000514 name: population viability phenotype namespace: single_species_phenotype def: "A single organism cell population phenotype that reflects the proportion of the population that survive and develop normally." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0002057 is_a: PHIPO:0000509 ! population phenotype created_by: alaynecuzick creation_date: 2019-02-11T13:07:36Z [Term] id: PHIPO:0000517 name: lipid droplets present in increased numbers namespace: single_species_phenotype def: "A single species phenotype observed in the vegetative growth phase of the life cycle in which cells contain more lipid droplets than normal." [] is_a: PHIPO:0000474 ! abnormal number of lipid droplets created_by: alaynecuzick creation_date: 2019-03-19T13:18:56Z [Term] id: PHIPO:0000518 name: lipid droplets present in normal numbers namespace: single_species_phenotype def: "A single species phenotype observed in the vegetative growth phase of the life cycle in which cells contain the same number of lipid droplets as normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0006791 is_a: PHIPO:0000159 ! normal subcellular component created_by: alaynecuzick creation_date: 2019-03-19T13:20:18Z [Term] id: PHIPO:0000519 name: resistance to piperacillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to piperacillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000520 name: resistance to florfenicol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to florfenicol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000521 name: resistance to boscalid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to boscalid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000523 name: resistance to sordarin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to sordarin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000524 name: resistance to ketoconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ketoconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000526 name: resistance to carbenicillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to carbenicillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000527 name: resistance to enrofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to enrofloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000528 name: resistance to prochloraz namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to prochloraz. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000529 name: resistance to virginiamycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to virginiamycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000530 name: resistance to triadimefon namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to triadimefon. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000531 name: resistance to cercosporamide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cercosporamide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000532 name: resistance to oxytetracycline namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to oxytetracycline. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000533 name: resistance to gramicidin D namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to gramicidin D. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000534 name: resistance to actinomycin D namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to actinomycin D. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000536 name: resistance to triclosan namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to triclosan. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000537 name: resistance to captan namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to captan. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000538 name: resistance to isoniazid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to isoniazid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000539 name: resistance to ciprofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ciprofloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000541 name: resistance to benznidazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to benznidazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000542 name: resistance to ethambutol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ethambutol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000543 name: resistance to teicoplanin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to teicoplanin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000544 name: resistance to cycloheximide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cycloheximide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000545 name: resistance to chlorothalonil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to chlorothalonil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000546 name: resistance to cefotetan namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefotetan. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000548 name: resistance to hygromycin B namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to hygromycin B. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000549 name: resistance to triclabendazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to triclabendazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000550 name: resistance to ampicillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ampicillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000551 name: resistance to brassinin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to brassinin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000553 name: resistance to aztreonam namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to aztreonam. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000554 name: resistance to nisin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nisin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000555 name: resistance to tetracycline namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tetracycline. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000556 name: resistance to moxifloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to moxifloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000557 name: resistance to myriocin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to myriocin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000558 name: resistance to benzylpenicillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to benzylpenicillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000559 name: resistance to latrunculin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to latrunculin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000560 name: resistance to clindamycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to clindamycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000561 name: resistance to tylosin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tylosin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000562 name: resistance to trovafloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to trovafloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000563 name: resistance to furazolidone namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to furazolidone. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000564 name: resistance to mecillinam namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to mecillinam. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000565 name: resistance to cefixime namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefixime. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000566 name: resistance to tridemorph namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tridemorph. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000567 name: resistance to mancozeb namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to mancozeb. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000569 name: resistance to netilmicin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to netilmicin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000570 name: resistance to sulfanilamide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to sulfanilamide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000571 name: resistance to leptomycin B namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to leptomycin B. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000572 name: resistance to bleomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to bleomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000573 name: resistance to gentamycin C1 namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to gentamycin C1. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000659 ! resistance to gentamicin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000574 name: resistance to pyrazinecarboxamide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to pyrazinecarboxamide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000575 name: resistance to micafungin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to micafungin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000576 name: resistance to strobilurin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to strobilurin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000577 name: resistance to nikkomycin Z namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nikkomycin Z. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000578 name: resistance to nifurtimox namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nifurtimox. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000579 name: resistance to rotenone namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to rotenone. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000580 name: resistance to sulfadimethoxine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to sulfadimethoxine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000581 name: resistance to flucytosine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to flucytosine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000582 name: resistance to cefuroxime namespace: single_species_phenotype alt_id: PHIPO:0000552 def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefuroxime. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000583 name: resistance to antimycin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to antimycin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000584 name: resistance to brefeldin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to brefeldin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000586 name: resistance to anidulafungin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to anidulafungin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000587 name: resistance to vinclozolin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to vinclozolin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000588 name: resistance to trimethoprim namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to trimethoprim. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000589 name: resistance to mupirocin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to mupirocin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000590 name: resistance to voriconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to voriconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000591 name: resistance to alexidine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to alexidine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000592 name: resistance to fludioxonil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fludioxonil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000593 name: resistance to oxacillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to oxacillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000594 name: resistance to cefpodoxime proxetil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefpodoxime proxetil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000596 name: resistance to eflornithine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to eflornithine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000597 name: resistance to polymyxin B1 namespace: single_species_phenotype alt_id: PHIPO:0000540 def: "A growth phenotype which describes the resistance of individuals or populations after exposure to polymyxin B1. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] synonym: "resistance to polymyxin B" RELATED [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000598 name: resistance to pyrimethanil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to pyrimethanil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000599 name: resistance to telithromycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to telithromycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000600 name: resistance to capreomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to capreomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000601 name: resistance to amikacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to amikacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000602 name: resistance to ethionamide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ethionamide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000603 name: resistance to doxycycline namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to doxycycline. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000604 name: resistance to meropenem namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to meropenem. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000693 ! resistance to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000605 name: resistance to 4-aminosalicylic acid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to 4-aminosalicylic acid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000606 name: resistance to rifampicin namespace: single_species_phenotype alt_id: PHIPO:0000535 def: "A growth phenotype which describes the resistance of individuals or populations after exposure to rifampicin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] synonym: "resistance to rifampin" RELATED [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000607 name: resistance to flutriafol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to flutriafol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000608 name: resistance to rifabutin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to rifabutin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000609 name: resistance to nalidixic acid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nalidixic acid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000610 name: resistance to linezolid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to linezolid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000611 name: resistance to fusidic acid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fusidic acid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000612 name: resistance to tunicamycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tunicamycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000613 name: resistance to epoxyconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to epoxyconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000615 name: resistance to D-cycloserine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to D-cycloserine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000616 name: resistance to kanamycin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to kanamycin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000617 name: resistance to verapamil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to verapamil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000618 name: resistance to streptomycin sulfate namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to streptomycin sulfate. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000619 name: resistance to farnesol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to farnesol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000620 name: resistance to fenpropidin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fenpropidin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000621 name: resistance to gatifloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to gatifloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000622 name: resistance to erythromycin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to erythromycin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000623 name: resistance to bifonazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to bifonazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000624 name: resistance to azithromycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to azithromycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000625 name: resistance to posaconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to posaconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000626 name: resistance to prothionamide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to prothionamide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000627 name: resistance to copper namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to copper. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000628 name: resistance to resveratrol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to resveratrol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000629 name: resistance to colistin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to colistin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000630 name: resistance to oligomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to oligomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000631 name: resistance to cefepime namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefepime. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000632 name: resistance to hydrogen peroxide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to hydrogen peroxide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000633 name: resistance to tigecycline namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tigecycline. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000634 name: resistance to tricyclazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tricyclazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000635 name: resistance to closantel namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to closantel. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000636 name: resistance to diniconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to diniconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000639 name: resistance to quinupristin-dalfopristin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to quinupristin-dalfopristin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000640 name: resistance to sparfloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to sparfloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000641 name: resistance to cefaclor namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefaclor. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000642 name: resistance to plumbagin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to plumbagin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000643 name: resistance to imipenem namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to imipenem. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000693 ! resistance to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000644 name: resistance to streptomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to streptomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000645 name: resistance to ticarcillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ticarcillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000646 name: resistance to fenhexamid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fenhexamid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000647 name: resistance to abamectin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to abamectin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000648 name: resistance to miltefosine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to miltefosine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000649 name: resistance to methicillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to methicillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000650 name: resistance to ertapenem namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ertapenem. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000693 ! resistance to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000651 name: resistance to neomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to neomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000652 name: resistance to rapamycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to rapamycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000653 name: resistance to fluconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fluconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000654 name: resistance to valinomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to valinomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000655 name: resistance to salicylhydroxamic acid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to salicylhydroxamic acid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000656 name: resistance to nicotinamide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nicotinamide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000657 name: resistance to sulbactam namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to sulbactam. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000658 name: resistance to amoxicillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to amoxicillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000659 name: resistance to gentamicin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to gentamicin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000660 name: resistance to ceftazidime namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ceftazidime. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000661 name: resistance to sulfisoxazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to sulfisoxazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000662 name: resistance to bacitracin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to bacitracin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000663 name: resistance to difenoconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to difenoconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000664 name: resistance to spiroxamine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to spiroxamine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000665 name: resistance to ofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ofloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000666 name: resistance to cyclosporine A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cyclosporine A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000667 name: resistance to cefotaxime namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefotaxime. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000668 name: resistance to cefoxitin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefoxitin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000669 name: resistance to fenarimol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fenarimol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000670 name: resistance to levofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to levofloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000671 name: resistance to spectinomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to spectinomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000672 name: resistance to pentamidine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to pentamidine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000673 name: resistance to thiabendazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to thiabendazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000674 name: resistance to chlortetracycline namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to chlortetracycline. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000675 name: resistance to itraconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to itraconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000676 name: resistance to nitrofurantoin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nitrofurantoin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000677 name: resistance to ceftriaxone namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to ceftriaxone. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000678 name: resistance to paromomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to paromomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000679 name: resistance to tebuconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tebuconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000681 name: resistance to nystatin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nystatin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000682 name: resistance to propiconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to propiconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000684 name: resistance to minocycline namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to minocycline. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000685 name: resistance to tobramycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tobramycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000686 name: resistance to caspofungin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to caspofungin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000688 name: resistance to amphotericin B namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to amphotericin B. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000689 name: resistance to chloramphenicol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to chloramphenicol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000690 name: resistance to novobiocin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to novobiocin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000691 name: resistance to emamectin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to emamectin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000692 name: resistance to penicillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to penicillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000693 name: resistance to carbapenems namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to carbapenems. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000694 name: resistance to daptomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to daptomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000695 name: resistance to clarithromycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to clarithromycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000696 name: resistance to copper sulphate namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to copper sulphate. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000697 name: resistance to fosfomycin namespace: single_species_phenotype alt_id: PHIPO:0000702 def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fosfomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] synonym: "resistance to phosphomycin" RELATED [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000698 name: resistance to trichostatin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to trichostatin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000699 name: resistance to doripenem namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to doripenem. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000693 ! resistance to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000700 name: resistance to miconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to miconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000701 name: resistance to vancomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to vancomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000703 name: resistance to aureobasidin A namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to aureobasidin A. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000704 name: resistance to lincomycin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to lincomycin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000705 name: resistance to norfloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to norfloxacin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000706 name: resistance to tiamulin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tiamulin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000707 name: resistance to hymexazol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to hymexazol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000708 name: resistance to cephalexin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cephalexin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000709 name: resistance to clofazimine namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to clofazimine. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000710 name: resistance to dicloxacillin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to dicloxacillin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000692 ! resistance to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000711 name: resistance to camptothecin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to camptothecin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000712 name: resistance to cefazolin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cefazolin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000713 name: sensitive to mupirocin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to mupirocin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000716 name: sensitive to cefixime namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefixime. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000717 name: sensitive to minocycline namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to minocycline. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000718 name: sensitive to polymyxin B1 namespace: single_species_phenotype alt_id: PHIPO:0000857 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to polymyxin B1. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] synonym: "sensitive to polymyxin B" RELATED [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000719 name: sensitive to fusidic acid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fusidic acid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000720 name: sensitive to brefeldin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to brefeldin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000721 name: sensitive to ethionamide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ethionamide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000722 name: sensitive to rotenone namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to rotenone. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000723 name: sensitive to pyrazinecarboxamide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to pyrazinecarboxamide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000724 name: sensitive to alexidine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to alexidine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000726 name: sensitive to chloramphenicol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to chloramphenicol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000727 name: sensitive to clofazimine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to clofazimine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000728 name: sensitive to emamectin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to emamectin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000729 name: sensitive to miltefosine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to miltefosine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000730 name: sensitive to sulfadimethoxine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to sulfadimethoxine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000732 name: sensitive to doripenem namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to doripenem. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000819 ! sensitive to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000733 name: sensitive to cefaclor namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefaclor. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000734 name: sensitive to plumbagin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to plumbagin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000735 name: sensitive to cefotaxime namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefotaxime. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000736 name: sensitive to benznidazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to benznidazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000737 name: sensitive to cyclosporine A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cyclosporine A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000738 name: sensitive to spectinomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to spectinomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000739 name: sensitive to latrunculin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to latrunculin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000740 name: sensitive to oxacillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to oxacillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000741 name: sensitive to difenoconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to difenoconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000742 name: sensitive to triclosan namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to triclosan. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000743 name: sensitive to tridemorph namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tridemorph. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000744 name: sensitive to virginiamycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to virginiamycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000745 name: sensitive to neomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to neomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000746 name: sensitive to voriconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to voriconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000747 name: sensitive to brassinin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to brassinin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000748 name: sensitive to daptomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to daptomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000749 name: sensitive to bleomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to bleomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000750 name: sensitive to aztreonam namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to aztreonam. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000751 name: sensitive to fludioxonil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fludioxonil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000753 name: sensitive to ceftriaxone namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ceftriaxone. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000754 name: sensitive to leptomycin B namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to leptomycin B. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000755 name: sensitive to amikacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to amikacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000756 name: sensitive to resveratrol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to resveratrol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000757 name: sensitive to fenhexamid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fenhexamid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000758 name: sensitive to cefpodoxime proxetil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefpodoxime proxetil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000759 name: sensitive to myriocin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to myriocin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000760 name: sensitive to gentamicin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to gentamicin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000761 name: sensitive to valinomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to valinomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000762 name: sensitive to tigecycline namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tigecycline. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000763 name: sensitive to moxifloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to moxifloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000764 name: sensitive to kanamycin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to kanamycin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000765 name: sensitive to methicillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to methicillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000766 name: sensitive to pentamidine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to pentamidine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000767 name: sensitive to gentamycin C1 namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to gentamycin C1. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000760 ! sensitive to gentamicin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000768 name: sensitive to thiabendazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to thiabendazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000769 name: sensitive to gatifloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to gatifloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000770 name: sensitive to mecillinam namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to mecillinam. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000771 name: sensitive to ampicillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ampicillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000772 name: sensitive to cefotetan namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefotetan. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000773 name: sensitive to nystatin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to nystatin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000774 name: sensitive to vinclozolin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to vinclozolin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000775 name: sensitive to flucytosine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to flucytosine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000776 name: sensitive to trichostatin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to trichostatin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000777 name: sensitive to oxytetracycline namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to oxytetracycline. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000778 name: sensitive to eflornithine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to eflornithine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000779 name: sensitive to streptomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to streptomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000780 name: sensitive to epoxyconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to epoxyconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000781 name: sensitive to trimethoprim namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to trimethoprim. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000782 name: sensitive to nifurtimox namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to nifurtimox. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000783 name: sensitive to clarithromycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to clarithromycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000784 name: sensitive to nisin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to nisin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000785 name: sensitive to sulfanilamide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to sulfanilamide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000786 name: sensitive to oligomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to oligomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000788 name: sensitive to fosfomycin namespace: single_species_phenotype alt_id: PHIPO:0000787 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fosfomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] synonym: "sensitive to phosphomycin" RELATED [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000789 name: sensitive to telithromycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to telithromycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000791 name: sensitive to nitrofurantoin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to nitrofurantoin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000792 name: sensitive to linezolid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to linezolid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000793 name: sensitive to anidulafungin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to anidulafungin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000795 name: sensitive to carbenicillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to carbenicillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000796 name: sensitive to tunicamycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tunicamycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000797 name: sensitive to caspofungin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to caspofungin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000798 name: sensitive to fenarimol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fenarimol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000799 name: sensitive to ciprofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ciprofloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000800 name: sensitive to farnesol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to farnesol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000801 name: sensitive to amphotericin B namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to amphotericin B. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000802 name: sensitive to vancomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to vancomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000803 name: sensitive to ketoconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ketoconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000804 name: sensitive to strobilurin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to strobilurin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000805 name: sensitive to colistin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to colistin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000806 name: sensitive to trovafloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to trovafloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000807 name: sensitive to triclabendazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to triclabendazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000808 name: sensitive to pyrimethanil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to pyrimethanil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000809 name: sensitive to florfenicol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to florfenicol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000810 name: sensitive to flutriafol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to flutriafol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000811 name: sensitive to teicoplanin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to teicoplanin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000812 name: sensitive to norfloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to norfloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000814 name: sensitive to closantel namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to closantel. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000815 name: sensitive to penicillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to penicillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000816 name: sensitive to prothionamide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to prothionamide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000817 name: sensitive to isoniazid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to isoniazid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000818 name: sensitive to salicylhydroxamic acid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to salicylhydroxamic acid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000819 name: sensitive to carbapenems namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to carbapenems. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000820 name: sensitive to abamectin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to abamectin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000822 name: sensitive to antimycin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to antimycin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000823 name: sensitive to cercosporamide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cercosporamide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000824 name: sensitive to tiamulin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tiamulin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000825 name: sensitive to tebuconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tebuconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000826 name: sensitive to ticarcillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ticarcillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000827 name: sensitive to nicotinamide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to nicotinamide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000828 name: sensitive to tricyclazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tricyclazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000829 name: sensitive to paromomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to paromomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000830 name: sensitive to ofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ofloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000831 name: sensitive to triadimefon namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to triadimefon. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000832 name: sensitive to copper sulphate namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to copper sulphate. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000833 name: sensitive to imipenem namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to imipenem. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000819 ! sensitive to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000834 name: sensitive to quinupristin-dalfopristin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to quinupristin-dalfopristin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000835 name: sensitive to aureobasidin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to aureobasidin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000836 name: sensitive to rifampicin namespace: single_species_phenotype alt_id: PHIPO:0000856 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to rifampicin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] synonym: "sensitive to rifampin" RELATED [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000837 name: sensitive to rifabutin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to rifabutin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000838 name: sensitive to diniconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to diniconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000839 name: sensitive to actinomycin D namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to actinomycin D. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000840 name: sensitive to dicloxacillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to dicloxacillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000841 name: sensitive to cefuroxime namespace: single_species_phenotype alt_id: PHIPO:0000821 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefuroxime. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000842 name: sensitive to piperacillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to piperacillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000843 name: sensitive to bacitracin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to bacitracin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000844 name: sensitive to propiconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to propiconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000845 name: sensitive to meropenem namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to meropenem. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000819 ! sensitive to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000846 name: sensitive to chlorothalonil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to chlorothalonil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000847 name: sensitive to posaconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to posaconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000848 name: sensitive to cephalexin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cephalexin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000850 name: sensitive to 4-aminosalicylic acid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to 4-aminosalicylic acid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000851 name: sensitive to captan namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to captan. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000853 name: sensitive to capreomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to capreomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000854 name: sensitive to gramicidin D namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to gramicidin D. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000855 name: sensitive to doxycycline namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to doxycycline. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000858 name: sensitive to bifonazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to bifonazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000859 name: sensitive to micafungin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to micafungin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000860 name: sensitive to ertapenem namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ertapenem. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000819 ! sensitive to carbapenems property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000861 name: sensitive to cycloheximide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cycloheximide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000862 name: sensitive to ceftazidime namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ceftazidime. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000863 name: sensitive to camptothecin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to camptothecin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000864 name: sensitive to netilmicin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to netilmicin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000865 name: sensitive to benzylpenicillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to benzylpenicillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000866 name: sensitive to hymexazol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to hymexazol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000867 name: sensitive to streptomycin sulfate namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to streptomycin sulfate. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000868 name: sensitive to chlortetracycline namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to chlortetracycline. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000869 name: sensitive to D-cycloserine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to D-cycloserine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000870 name: sensitive to miconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to miconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000871 name: sensitive to erythromycin A namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to erythromycin A. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000872 name: sensitive to copper namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to copper. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000873 name: sensitive to rapamycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to rapamycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000874 name: sensitive to tobramycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tobramycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000875 name: sensitive to verapamil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to verapamil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000876 name: sensitive to furazolidone namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to furazolidone. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000877 name: sensitive to cefoxitin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefoxitin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000878 name: sensitive to fenpropidin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fenpropidin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000879 name: sensitive to itraconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to itraconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000880 name: sensitive to sulfisoxazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to sulfisoxazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000881 name: sensitive to lincomycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to lincomycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000882 name: sensitive to tetracycline namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tetracycline. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000883 name: sensitive to levofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to levofloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000884 name: sensitive to cefazolin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefazolin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000885 name: sensitive to novobiocin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to novobiocin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000886 name: sensitive to amoxicillin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to amoxicillin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000815 ! sensitive to penicillin property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000887 name: sensitive to ethambutol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to ethambutol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000888 name: sensitive to tylosin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tylosin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000889 name: sensitive to clindamycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to clindamycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000890 name: sensitive to fluconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fluconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000891 name: sensitive to hygromycin B namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to hygromycin B. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000892 name: sensitive to boscalid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to boscalid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000893 name: sensitive to cefepime namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cefepime. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000894 name: sensitive to prochloraz namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to prochloraz. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000895 name: sensitive to mancozeb namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to mancozeb. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000896 name: sensitive to spiroxamine namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to spiroxamine. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000897 name: sensitive to enrofloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to enrofloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000898 name: sensitive to nalidixic acid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to nalidixic acid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000899 name: sensitive to sordarin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to sordarin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000901 name: sensitive to azithromycin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to azithromycin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000902 name: sensitive to sparfloxacin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to sparfloxacin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000903 name: sensitive to nikkomycin Z namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to nikkomycin Z. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000904 name: sensitive to sulbactam namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to sulbactam. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical property_value: created:by "alaynecuzick" xsd:string property_value: creation:date "2018-03-20T14:29:00Z" xsd:dateTime [Term] id: PHIPO:0000924 name: host defense-induced oxidative burst level phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, which affects a pathogen induced host oxidative burst level (GO:0002679)." [] comment: Definition adapted from GO:0002679 respiratory burst involved in defense response. synonym: "pathogen host interaction respiratory burst phenotype" EXACT [] synonym: "pathogen induced host oxidative burst level phenotype" EXACT [] synonym: "pathogen-induced host oxidative burst level phenotype" EXACT [] xref: GO:0002679 is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2019-05-01T09:18:19Z [Term] id: PHIPO:0000925 name: abnormal cell wall organization or biogenesis namespace: single_species_phenotype def: "A cellular process phenotype in which the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall is abnormal." [] synonym: "abnormal cell wall integrity" EXACT [] is_a: PHIPO:0000929 ! abnormal cellular process is_a: PHIPO:0000931 ! cell wall organization or biogenesis phenotype created_by: alaynecuzick creation_date: 2019-05-01T10:52:19Z [Term] id: PHIPO:0000927 name: host defense-induced reactive oxygen species present namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000926 def: "A pathogen host interaction phenotype, in which the level of host reactive oxygen species (ROS) often associated with an oxidative burst response during infection is present." [] synonym: "host H202 production resulting from oxidative burst" EXACT [] synonym: "increased host H202 production resulting from oxidative burst" EXACT [] synonym: "pathogen induced host oxidative burst present" EXACT [] synonym: "pathogen induced host reactive oxygen species present" EXACT [] synonym: "pathogen induced host respiratory burst present" EXACT [] synonym: "pathogen induced host ROS present" EXACT [] synonym: "pathogen-induced host reactive oxygen species present" EXACT [] synonym: "pathogen-induced host ROS present" EXACT [] synonym: "presence of pathogen induced host reactive oxygen species" RELATED [] synonym: "presence of pathogen induced host ROS" EXACT [] is_a: PHIPO:0000924 ! host defense-induced oxidative burst level phenotype created_by: alaynecuzick creation_date: 2019-05-01T10:52:28Z [Term] id: PHIPO:0000928 name: host defense-induced reactive oxygen species absent namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host reactive oxygen species (ROS) often associated with an oxidative burst response during infection is absent or at a level too low to detect." [] synonym: "absence of pathogen induced host reactive oxygen species" RELATED [] synonym: "absence of pathogen induced host ROS" EXACT [] synonym: "pathogen induced host oxidative burst absent" EXACT [] synonym: "pathogen induced host reactive oxygen species absent" EXACT [] synonym: "pathogen induced host respiratory burst absent" EXACT [] synonym: "pathogen induced host ROS absent" EXACT [] synonym: "pathogen-induced host reactive oxygen species absent" EXACT [] synonym: "pathogen-induced host ROS absent" EXACT [] is_a: PHIPO:0000924 ! host defense-induced oxidative burst level phenotype created_by: alaynecuzick creation_date: 2019-05-01T10:53:36Z [Term] id: PHIPO:0000929 name: abnormal cellular process namespace: single_species_phenotype def: "A phenotype in which a specific cellular process is abnormal." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000628 is_a: PHIPO:0000930 ! cellular process phenotype created_by: alaynecuzick creation_date: 2019-05-01T10:58:54Z [Term] id: PHIPO:0000930 name: cellular process phenotype namespace: single_species_phenotype def: "A phenotype that affects a cellular process." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000114 is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2019-05-01T10:59:15Z [Term] id: PHIPO:0000931 name: cell wall organization or biogenesis phenotype namespace: single_species_phenotype def: "A phenotype that affects cell wall organization or biogenesis." [] synonym: "cell wall integrity phenotype" EXACT [] is_a: PHIPO:0000930 ! cellular process phenotype created_by: alaynecuzick creation_date: 2019-05-01T10:59:55Z [Term] id: PHIPO:0000932 name: normal cellular process namespace: single_species_phenotype def: "A phenotype in which a specific cellular process is normal (i.e. indistinguishable from wild type)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000627 is_a: PHIPO:0000930 ! cellular process phenotype created_by: alaynecuzick creation_date: 2019-05-01T11:00:10Z [Term] id: PHIPO:0000934 name: abnormal nucleus namespace: single_species_phenotype def: "A single organism phenotype in which the amount, distribution, or morphology of all or part of the nucleus is abnormal." [] xref: FYPO:0002403 is_a: PHIPO:0000415 ! abnormal subcellular component created_by: alaynecuzick creation_date: 2019-05-08T13:37:01Z [Term] id: PHIPO:0000935 name: decreased cell wall integrity namespace: single_species_phenotype def: "A cellular process phenotype in which the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall is decreased." [] synonym: "decreased cell wall organization or biogenesis" EXACT [] is_a: PHIPO:0000925 ! abnormal cell wall organization or biogenesis created_by: alaynecuzick creation_date: 2019-05-17T10:49:13Z [Term] id: PHIPO:0000936 name: cell lysis namespace: single_species_phenotype def: "An single species phenotype in which a cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost." [] xref: FYPO:0002488 is_a: PHIPO:0001222 ! cell viability phenotype created_by: alaynecuzick creation_date: 2019-05-21T10:29:14Z [Term] id: PHIPO:0000937 name: asexual spore lysis present namespace: single_species_phenotype def: "An single species phenotype in which an asexual spore lyses, i.e. the plasma membrane ruptures and cytoplasm is lost." [] synonym: "asexual spore cytolysis present" EXACT [] synonym: "conidia lysis present" EXACT [] xref: FYPO:0002489 is_a: PHIPO:0000936 ! cell lysis created_by: alaynecuzick creation_date: 2019-05-21T10:29:30Z [Term] id: PHIPO:0000938 name: vegetative cell lysis namespace: single_species_phenotype def: "An single species phenotype in which a vegetative cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost." [] xref: FYPO:0000647 is_a: PHIPO:0000936 ! cell lysis created_by: alaynecuzick creation_date: 2019-05-21T10:30:07Z [Term] id: PHIPO:0000939 name: asexual spore lysis absent namespace: single_species_phenotype def: "An single species phenotype in which an asexual spore does not lyse, i.e. the plasma membrane ruptures and cytoplasm is lost." [] synonym: "asexual spore cytolysis absent" EXACT [] synonym: "conidia lysis absent" EXACT [] xref: FYPO:0002489 is_a: PHIPO:0000936 ! cell lysis created_by: alaynecuzick creation_date: 2019-05-21T11:22:31Z [Term] id: PHIPO:0000940 name: abnormal germ tube namespace: single_species_phenotype def: "A single species phenotype where the slender tubular outgrowth first produced by most spores in germination is abnormal. (GO:0032179)" [] is_a: PHIPO:0000415 ! abnormal subcellular component created_by: alaynecuzick creation_date: 2019-05-21T11:34:47Z [Term] id: PHIPO:0000941 name: short germ tube namespace: single_species_phenotype def: "A single species phenotype where the slender tubular outgrowth first produced by most spores in germination is shorter than normal. (GO:0032179)" [] is_a: PHIPO:0000940 ! abnormal germ tube created_by: alaynecuzick creation_date: 2019-05-21T11:35:21Z [Term] id: PHIPO:0000943 name: sensitive to hydrogen peroxide namespace: single_species_phenotype alt_id: PHIPO:0000849 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to hydrogen peroxide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical is_a: PHIPO:0001398 ! sensitive to oxidative stress property_value: created:by "alaynecuzick" xsd:string creation_date: 2019-05-21T11:55:15Z [Term] id: PHIPO:0000944 name: altered level of substance in cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of a specific substance measured in a cell differs from normal." [] synonym: "abnormal level of substance in cell" EXACT [] xref: FYPO:0000989 is_a: PHIPO:0000404 ! abnormal cell phenotype created_by: alaynecuzick creation_date: 2019-05-21T11:59:04Z [Term] id: PHIPO:0000945 name: altered cellular reactive oxygen species level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell differs from normal." [] synonym: "abnormal cellular reactive oxygen species level" EXACT [] synonym: "abnormal cellular ROS accumulation" RELATED [] synonym: "abnormal cellular ROS level" EXACT [] synonym: "altered cellular ROS level" EXACT [] xref: FYPO:0002142 is_a: PHIPO:0000944 ! altered level of substance in cell created_by: alaynecuzick creation_date: 2019-05-21T12:00:07Z [Term] id: PHIPO:0000946 name: decreased cellular reactive oxygen species level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell is lower than normal." [] synonym: "decreased cellular ROS level" EXACT [] synonym: "reduced cellular ROS level" EXACT [] is_a: PHIPO:0000945 ! altered cellular reactive oxygen species level is_a: PHIPO:0001035 ! decreased level of substance in cell created_by: alaynecuzick creation_date: 2019-05-21T12:01:32Z [Term] id: PHIPO:0000947 name: increased cellular reactive oxygen species level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell is higher than normal." [] synonym: "increased cellular ROS level" EXACT [] is_a: PHIPO:0000945 ! altered cellular reactive oxygen species level is_a: PHIPO:0001036 ! increased level of substance in cell created_by: alaynecuzick creation_date: 2019-05-21T12:01:41Z [Term] id: PHIPO:0000948 name: mutualism absent namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction where the mutualism phenotype is normal (i.e. the same as wild-type), and the wild-type interaction does not exhibit mutualism." [] subset: qc_do_not_annotate is_a: PHIPO:0000039 ! normal mutualism created_by: alaynecuzick creation_date: 2019-05-24T11:02:11Z [Term] id: PHIPO:0000949 name: pathogen entry into host phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype which affects the penetration of the pathogen into the body, tissues, or cells of the host organism (GO:0044409)." [] comment: This covers formation of any penetration structure, the process of penetration, and phenotypes which affect number of penetration structures, or the timing. is_a: PHIPO:0000332 ! pathogen colonization of host phenotype created_by: alaynecuzick creation_date: 2019-05-24T11:54:37Z [Term] id: PHIPO:0000950 name: obsolete pathogen spore germination on host phenotype namespace: pathogen_host_interaction_phenotype comment: Note: to add asexual/sexual etc is_obsolete: true created_by: alaynecuzick creation_date: 2019-05-24T12:00:40Z [Term] id: PHIPO:0000951 name: pathogen growth within host phenotype namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000471 def: "A pathogen host phenotype which affects the vegetative growth or proliferation of the pathogen inside the host (e.g. after entry by penetration or infiltration)." [] synonym: "pathogen biomass within host phenotype" RELATED [] is_a: PHIPO:0000332 ! pathogen colonization of host phenotype created_by: alaynecuzick creation_date: 2019-05-24T12:07:04Z [Term] id: PHIPO:0000952 name: abolished pathogen growth within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype in which the vegetative growth or proliferation of the pathogen inside the host is abolished (it was present as is now absent)." [] is_a: PHIPO:0000363 ! absence of pathogen growth within host created_by: alaynecuzick creation_date: 2019-05-24T12:21:58Z [Term] id: PHIPO:0000953 name: pathogen penetration structure present when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the pathogen specialized host penetration structure is present." [] synonym: "pathogen infection structure present when near host" EXACT [] is_a: PHIPO:0000352 ! normal formation of pathogen penetration structure prior to entry into host created_by: alaynecuzick creation_date: 2019-05-24T12:23:57Z [Term] id: PHIPO:0000954 name: presence of pathogen growth within host namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000354 def: "A pathogen host phenotype in which the vegetative growth or proliferation of the pathogen inside the host is present." [] synonym: "normal pathogen growth within host" RELATED [] synonym: "normal post penetration of host by pathogen" EXACT [] synonym: "pathogen growth present within host" EXACT [] is_a: PHIPO:0000951 ! pathogen growth within host phenotype created_by: alaynecuzick creation_date: 2019-05-24T12:25:01Z [Term] id: PHIPO:0000955 name: abolished formation of pathogen penetration structure when near host namespace: pathogen_host_interaction_phenotype def: "A pathogen growth with host phenotype in which the ability of the pathogen to form a specialized penetration structure is abolished." [] synonym: "abolished formation of pathogen infection structure when near host" EXACT [] is_a: PHIPO:0000369 ! abnormal formation of pathogen penetration structure when near host created_by: alaynecuzick creation_date: 2019-05-24T13:17:03Z [Term] id: PHIPO:0000956 name: normal asexual spore germination frequency namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spore germination is normal (i.e. indistinguishable from wild type)." [] synonym: "normal conidia germination frequency" EXACT [] is_a: PHIPO:0000509 ! population phenotype created_by: alaynecuzick creation_date: 2019-06-10T09:09:38Z [Term] id: PHIPO:0000959 name: normal cellular melanin accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of melanin in a cell is normal." [] synonym: "melanization" EXACT [] is_a: PHIPO:0000286 ! normal cellular pigment accumulation created_by: alaynecuzick creation_date: 2019-06-11T09:24:45Z [Term] id: PHIPO:0000961 name: obsolete cell morphology phenotype namespace: single_species_phenotype def: "A single species phenotype that affects the morphology of a cell." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-06-11T10:58:14Z [Term] id: PHIPO:0000962 name: decreased filamentous growth on host surface namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype where the vegetative growth or proliferation of the pathogen on the host surface is decreased." [] is_a: PHIPO:0000349 ! presence of pathogen growth on host surface created_by: alaynecuzick creation_date: 2019-06-12T10:48:26Z [Term] id: PHIPO:0000964 name: loss of virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is abolished on a specific host genotype." [] comment: For use in the annotation extension infective ability. Note this pathogen may still be pathogenic on an alternate host genotype. Note that avirulence means loss of pathogenicity in medical terminology. subset: qc_do_not_annotate synonym: "abolished virulence" EXACT [] synonym: "avirulence" RELATED [] is_a: PHIPO:0000015 ! reduced virulence created_by: alaynecuzick creation_date: 2019-06-26T11:54:44Z [Term] id: PHIPO:0000965 name: obsolete loss of virulence of gain of pathogenicity mutant namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is abolished when observed in an interaction with a pathogen mutant which was previously engineered to gain pathogenicity." [] comment: For use in the annotation extension infective ability. Note this pathogen may still be pathogenic on an alternate host genotype. subset: qc_extension_only is_obsolete: true created_by: alaynecuzick creation_date: 2019-06-26T12:27:44Z [Term] id: PHIPO:0000966 name: pathogen penetration structure present namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the pathogen specialized host penetration structure is present when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "pathogen infection structure present" EXACT [] is_a: PHIPO:0000028 ! normal formation of pathogen penetration structure created_by: alaynecuzick creation_date: 2019-07-05T09:48:18Z [Term] id: PHIPO:0000967 name: abolished pathogen penetration across the barrier namespace: single_species_phenotype def: "A single species pathogen penetration phenotype in in which the ability of the pathogen to penetrate a given experimental substance/membrane is abolished." [] subset: pathogen_phenotype is_a: PHIPO:0000030 ! pathogen penetration across the barrier absent created_by: alaynecuzick creation_date: 2019-07-05T10:18:20Z [Term] id: PHIPO:0000968 name: absent pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the pathogen's ability to contine to grow after penetration of a given experimental substance/membrane in an in vitro assay is absent." [] subset: pathogen_phenotype is_a: PHIPO:0000027 ! normal pathogen growth after penetration of the barrier created_by: alaynecuzick creation_date: 2019-07-05T11:08:06Z [Term] id: PHIPO:0000969 name: present pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the pathogen's ability to contine to grow after penetration of a given experimental substance/membrane in an in vitro assay is present." [] subset: pathogen_phenotype is_a: PHIPO:0000027 ! normal pathogen growth after penetration of the barrier created_by: alaynecuzick creation_date: 2019-07-05T11:08:42Z [Term] id: PHIPO:0000970 name: autophagosomes present in decreased numbers namespace: single_species_phenotype def: "A single organism phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer autophagosomes than normal (GO:0005776)." [] is_a: PHIPO:0000973 ! autophagosome phenotype created_by: alaynecuzick creation_date: 2019-07-16T11:41:18Z [Term] id: PHIPO:0000971 name: abolished formation of autophagosomes namespace: single_species_phenotype def: "A single organism phenotype observed in the vegetative growth phase of the life cycle in which the ability of the organism to form autophagosomes is abolished (they were present and are now absent) (GO:0005776)." [] is_a: PHIPO:0000973 ! autophagosome phenotype created_by: alaynecuzick creation_date: 2019-07-16T12:03:12Z [Term] id: PHIPO:0000972 name: abolished protein localization to autophagosome namespace: single_species_phenotype def: "A single organism phenotype in which a protein does not localize to, and is therefore absent from the autophagosome (GO:0005776)." [] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: PHIPO:0000245 ! abolished protein localization is_a: PHIPO:0000973 ! autophagosome phenotype created_by: alaynecuzick creation_date: 2019-07-16T13:07:53Z [Term] id: PHIPO:0000973 name: autophagosome phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects a double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy (GO:0005776)." [] is_a: PHIPO:0000415 ! abnormal subcellular component created_by: alaynecuzick creation_date: 2019-07-16T13:22:46Z [Term] id: PHIPO:0000974 name: decreased unicellular population growth namespace: single_species_phenotype def: "A single species population growth phenotype where the rate or extent of the increase in the number of unicellular organisms in the population (i.e organismal growth and reproduction) is lesser than normal." [] synonym: "slower growth" RELATED [] xref: FYPO:0000046 is_a: PHIPO:0000414 ! abnormal unicellular population growth is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2019-07-27T10:55:41Z [Term] id: PHIPO:0000975 name: increased unicellular population growth namespace: single_species_phenotype def: "A single species population growth phenotype where the rate or extent of the increase in the number of unicellular organisms in the population (i.e organismal growth and reproduction) is greater than normal." [] synonym: "faster growth" RELATED [] xref: FYPO:0003937 is_a: PHIPO:0000414 ! abnormal unicellular population growth is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2019-07-27T10:58:04Z [Term] id: PHIPO:0000976 name: decreased lipid droplet degradation namespace: single_species_phenotype def: "A single organism metabolic process phenotype in which the occurrence of lipid droplet degradation (lipolysis) is decreased (GO:0016042 and GO:0005811)." [] synonym: "decreased lipolysis" EXACT [] is_a: PHIPO:0000478 ! lipid droplet phenotype is_a: PHIPO:0000493 ! primary metabolic process phenotype created_by: alaynecuzick creation_date: 2019-07-27T11:17:17Z [Term] id: PHIPO:0000977 name: sensitive to sodium dodecyl sulfate namespace: single_species_phenotype def: "A phenotype in which a population of a single-species shows increased sensitivity to sodium dodecyl sulfate (SDS), manifested as an affect on the extent of population growth. (CHEBI:8984)." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2019-07-27T11:30:10Z [Term] id: PHIPO:0000978 name: sensitive to sodium chloride namespace: single_species_phenotype def: "A phenotype in which a population of a single-species shows increased sensitivity to sodium chloride, manifested as an affect on the extent of population growth. (CHEBI:26710)." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2019-07-27T11:32:29Z [Term] id: PHIPO:0000979 name: sensitive to dithiothreitol namespace: single_species_phenotype def: "A phenotype in which a population of a single-species shows increased sensitivity to 1,4-dithiothreitol (DTT), manifested as an affect on the extent of population growth. (CHEBI:18320)." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2019-07-27T11:32:42Z [Term] id: PHIPO:0000980 name: normal sexual spore morphology namespace: single_species_phenotype def: "A reproductive phenotype where the morphology of the sexual spore is normal (FAO:0000017). The product of meiosis." [] is_a: PHIPO:0000046 ! normal sexual reproduction created_by: alaynecuzick creation_date: 2019-07-27T12:17:27Z [Term] id: PHIPO:0000981 name: abnormal meiosis namespace: single_species_phenotype def: "A reproductive process phenotype in which meiosis is abnormal. Meiosis refers specifically to the nuclear division phases of a meiotic cell cycle. (GO:0140013)." [] synonym: "abnormal meiotic nuclear division" EXACT [] xref: FYPO:0000051 is_a: PHIPO:0000400 ! abnormal cellular component organization is_a: PHIPO:0000983 ! abnormal meiotic cell cycle created_by: alaynecuzick creation_date: 2019-07-27T13:29:17Z [Term] id: PHIPO:0000982 name: normal meiosis namespace: single_species_phenotype def: "A reproductive process phenotype in which the meiotic nuclear divisions are normal (i.e. indistinguishable from wild type). (GO:0140013)." [] synonym: "normal meiotic nuclear division" EXACT [] xref: FYPO:0000478 is_a: PHIPO:0000984 ! normal meiotic cell cycle created_by: alaynecuzick creation_date: 2019-07-27T13:33:11Z [Term] id: PHIPO:0000983 name: abnormal meiotic cell cycle namespace: single_species_phenotype def: "A reproductive process phenotype in which a cell does not proceed normally through a meiotic cell cycle (GO:0051321)." [] xref: FYPO:0000052 is_a: PHIPO:0000048 ! abnormal sexual reproduction is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2019-07-27T13:48:15Z [Term] id: PHIPO:0000984 name: normal meiotic cell cycle namespace: single_species_phenotype def: "A reproductive process phenotype in which a cell proceeds normally through a meiotic cell cycle (GO:0051321)." [] is_a: PHIPO:0000046 ! normal sexual reproduction created_by: alaynecuzick creation_date: 2019-07-27T13:52:11Z [Term] id: PHIPO:0000985 name: decreased extent of pathogen-associated host lesions namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000223 alt_id: PHIPO:0000225 def: "A phenotype where the process of host tissue cell death causing a host lesion occurs to a lesser extent than normal." [] comment: The lesion can be induced by either the pathogen directly killing host tissue (e.g. cell wall degradation), or the host activating its own cell death pathways in defense. synonym: "decreased number of pathogen-associated host lesions" RELATED [] synonym: "decreased size of pathogen-associated host lesion" RELATED [] is_a: PHIPO:0000480 ! presence of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2018-10-02T08:58:26Z [Term] id: PHIPO:0000986 name: increased extent of pathogen-associated host lesions namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000221 alt_id: PHIPO:0000222 def: "A phenotype where the process of host tissue cell death causing a host lesion occurs to a greater extent than normal." [] comment: The lesion can be induced by either the pathogen directly killing host tissue (e.g. cell wall degradation), or the host activating its own cell death pathways in defense. synonym: "increased number of pathogen-associated host lesions" RELATED [] synonym: "increased size of pathogen-associated host lesion" RELATED [] is_a: PHIPO:0000480 ! presence of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2018-10-02T08:56:00Z [Term] id: PHIPO:0000987 name: obsolete altered level of substance phenotype in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of a specific substance measured in a cell within a pathogen host interaction differs from normal." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T12:17:39Z [Term] id: PHIPO:0000988 name: obsolete altered protein level in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of protein measured in a pathogen or host cell differs from normal. Total protein or a specific protein may be affected." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T12:19:50Z [Term] id: PHIPO:0000989 name: decreased level of pathogen protein within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen protein usually present during infection is lower than normal." [] is_a: PHIPO:0001197 ! level of pathogen produced substance within host phenotype created_by: alaynecuzick creation_date: 2019-08-10T12:20:29Z [Term] id: PHIPO:0000990 name: obsolete absence of pathogen protein with host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the pathogen produced protein usually present during infection is absent." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T12:20:59Z [Term] id: PHIPO:0000991 name: increased level of host defense-induced protein namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host protein usually present during infection is higher than normal." [] synonym: "increased level of host protein involved in a pathogen host interaction" EXACT [] is_a: PHIPO:0001262 ! host defense-induced protein level phenotype created_by: alaynecuzick creation_date: 2019-08-10T12:22:12Z [Term] id: PHIPO:0000992 name: increased expression of a host defense-related protein involved in a pathogen interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host defense-related protein usually present during infection is higher than normal." [] synonym: "increased expression of a host defense related protein involved in a pathogen interaction" EXACT [] is_a: PHIPO:0000991 ! increased level of host defense-induced protein created_by: alaynecuzick creation_date: 2019-08-10T12:23:36Z [Term] id: PHIPO:0000993 name: obsolete altered RNA level in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of RNA measured in a pathogen or host cell differs from normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T12:30:53Z [Term] id: PHIPO:0000994 name: obsolete decreased RNA level in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of RNA measured in a pathogen or host cell is lower than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T12:31:25Z [Term] id: PHIPO:0000995 name: decreased level of pathogen RNA within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen RNA usually present during infection is lower than normal." [] is_a: PHIPO:0001267 ! level of pathogen produced RNA within host phenotype created_by: alaynecuzick creation_date: 2019-08-10T12:32:05Z [Term] id: PHIPO:0000998 name: pathogen morphology phenotype during colonization of host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the pathogen morphology during host colonization. This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2019-08-10T13:48:27Z [Term] id: PHIPO:0000999 name: abnormal pathogen morphology during colonization of host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the pathogen during host colonization is abnormal. This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] is_a: PHIPO:0000998 ! pathogen morphology phenotype during colonization of host created_by: alaynecuzick creation_date: 2019-08-10T13:49:02Z [Term] id: PHIPO:0001000 name: abnormal pathogen swollen terminal hyphae during cell to cell migration namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the pathogen terminal hyphae during host colonization is abnormal. This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] synonym: "abnormal pathogen swollen terminal hyphae during colonization of host" EXACT [] is_a: PHIPO:0000334 ! abnormal pathogen cell to cell migration within host is_a: PHIPO:0000999 ! abnormal pathogen morphology during colonization of host created_by: alaynecuzick creation_date: 2019-08-10T13:49:58Z [Term] id: PHIPO:0001001 name: abnormal organization of pathogen septin collar during cell to cell migration namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the pathogen septin collar (GO:0032173) during host colonization is abnormal. This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] comment: update Go term when available to 'septin collar of invasive fungi' synonym: "abnormal organization of pathogen septin collar during colonization of host" RELATED [] is_a: PHIPO:0000334 ! abnormal pathogen cell to cell migration within host is_a: PHIPO:0000999 ! abnormal pathogen morphology during colonization of host created_by: alaynecuzick creation_date: 2019-08-10T13:51:23Z [Term] id: PHIPO:0001002 name: host morphology phenotype during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the host morphology during pathogen invasion. This relates to the pathogen colonization of the body, tissues, or cells of the host organism" [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2019-08-10T13:51:57Z [Term] id: PHIPO:0001003 name: normal formation of extra-invasive hyphal membrane namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the host extra-invasive hyphal membrane (GO:0085039) during pathogen invasion is normal (indistinguishable from wild type). This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] synonym: "normal formation of BIC (biotrophic interfacial complex)" EXACT [] is_a: PHIPO:0001005 ! normal host morphology during pathogen invasion created_by: alaynecuzick creation_date: 2019-08-10T13:52:53Z [Term] id: PHIPO:0001004 name: normal pathogen morphology during colonization of host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the pathogen during host colonization is normal (indistinguishable from wild type). This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] is_a: PHIPO:0000998 ! pathogen morphology phenotype during colonization of host created_by: alaynecuzick creation_date: 2019-08-10T13:56:49Z [Term] id: PHIPO:0001005 name: normal host morphology during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the host during pathogen invasion is normal (indistinguishable from wild type). This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] is_a: PHIPO:0001002 ! host morphology phenotype during pathogen invasion created_by: alaynecuzick creation_date: 2019-08-10T13:58:16Z [Term] id: PHIPO:0001006 name: abnormal host morphology during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the host during pathogen invasion is abnormal. This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] is_a: PHIPO:0001002 ! host morphology phenotype during pathogen invasion created_by: alaynecuzick creation_date: 2019-08-10T13:58:30Z [Term] id: PHIPO:0001007 name: obsolete pathogen colonization of host morphology phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the morphology of the pathogen or the host during pathogen colonization of the host. This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T14:19:52Z [Term] id: PHIPO:0001008 name: abnormal transport during vegetative growth namespace: single_species_phenotype def: "A phenotype in which a specific transport process is abnormal in the vegetative growth phase of the life cycle." [] xref: FYPO:0005973 is_a: PHIPO:0000257 ! abnormal transport created_by: alaynecuzick creation_date: 2019-08-10T15:03:45Z [Term] id: PHIPO:0001009 name: abnormal vesicle-mediated transport during vegetative growth namespace: single_species_phenotype def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which vesicle-mediated transport is abnormal." [] xref: FYPO:0000213 is_a: PHIPO:0000257 ! abnormal transport created_by: alaynecuzick creation_date: 2019-08-10T15:06:50Z [Term] id: PHIPO:0001010 name: normal vesicle-mediated transport during vegetative growth namespace: single_species_phenotype def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which vesicle-mediated transport is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0006432 is_a: PHIPO:0001011 ! normal transport created_by: alaynecuzick creation_date: 2019-08-10T15:06:57Z [Term] id: PHIPO:0001011 name: normal transport namespace: single_species_phenotype def: "A single organism cellular process phenotype observed in the vegetative growth phase of the life cycle in which transport is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0001071 is_a: PHIPO:0000256 ! transport phenotype created_by: alaynecuzick creation_date: 2019-08-10T15:11:18Z [Term] id: PHIPO:0001012 name: obsolete pathogen host interaction polysaccharide localization phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the localization of a polysaccharide in a pathogen or host cell is abnormal. This includes any process in which a polysaccharide is transported to, or maintained in, a specific location. (GO:0033037)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T16:33:27Z [Term] id: PHIPO:0001013 name: obsolete abnormal pathogen host interaction polysaccharide localization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of a polysaccharide in a pathogen or host cell is abnormal. This includes any process in which a polysaccharide is transported to, or maintained in, a specific location. (GO:0033037)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T16:36:54Z [Term] id: PHIPO:0001014 name: increased level of host defense-induced callose deposition namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host produced callose deposition usually present during infection is higher than normal." [] comment: GO:0052542 synonym: "increased level of host callose deposition induced by pathogen" EXACT [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2019-08-10T16:37:53Z [Term] id: PHIPO:0001015 name: decreased level of host defense-induced callose deposition namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host produced callose deposition usually present during infection is lower than normal." [] comment: GO:0052542 synonym: "decreased level of host callose deposition induced by pathogen" EXACT [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2019-08-10T16:38:36Z [Term] id: PHIPO:0001016 name: obsolete altered level of host callose deposition induced by pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where any process in which callose is transported to, and/or maintained in, a specific location during the host defense response to a pathogen is abnormal. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. (GO:0052542)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-08-10T16:43:59Z [Term] id: PHIPO:0001017 name: long germ tube namespace: single_species_phenotype def: "A single species phenotype where the slender tubular outgrowth first produced by most spores in germination is longer than normal. (GO:0032179)" [] is_a: PHIPO:0000940 ! abnormal germ tube created_by: alaynecuzick creation_date: 2019-08-17T12:54:34Z [Term] id: PHIPO:0001018 name: abnormal asexual spore germination namespace: single_species_phenotype def: "A cellular process phenotype in which asexual spore germination is abnormal (GO:0009847)." [] synonym: "abnormal conidia germination" EXACT [] xref: FYPO:0000305 is_a: PHIPO:0000930 ! cellular process phenotype created_by: alaynecuzick creation_date: 2019-08-17T12:59:57Z [Term] id: PHIPO:0001019 name: decreased rate of asexual spore germination namespace: single_species_phenotype def: "A cellular process phenotype in which the rate, or speed, of asexual spore germination is decreased." [] synonym: "decreased rate of conidia germination" EXACT [] xref: FYPO:0000582 is_a: PHIPO:0000929 ! abnormal cellular process is_a: PHIPO:0001018 ! abnormal asexual spore germination created_by: alaynecuzick creation_date: 2019-08-17T13:01:16Z [Term] id: PHIPO:0001020 name: sensitive to calcofluor white namespace: single_species_phenotype def: "A phenotype in which a population of a single-species shows increased sensitivity to calcofluor white, manifested as an affect on the extent of population growth. (CHEBI:50011)" [] xref: FYPO:0001188 is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2019-08-17T13:35:49Z [Term] id: PHIPO:0001021 name: sensitive to congo red namespace: single_species_phenotype def: "A phenotype in which a population of a single-species shows increased sensitivity to congo red, manifested as an affect on the extent of population growth. (CHEBI:34653)." [] xref: FYPO:0005984 is_a: PHIPO:0000021 ! increased sensitivity to chemical is_a: PHIPO:0001397 ! sensitive to cell wall stress created_by: alaynecuzick creation_date: 2019-08-17T13:36:09Z [Term] id: PHIPO:0001022 name: altered cellular cAMP level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of cyclic AMP measured in a cell differs from normal." [] synonym: "abnormal cellular cAMP level" EXACT [] synonym: "altered cellular cyclic AMP level" EXACT [] xref: FYPO:0001659 is_a: PHIPO:0000944 ! altered level of substance in cell created_by: alaynecuzick creation_date: 2019-08-17T13:47:08Z [Term] id: PHIPO:0001023 name: decreased cellular cAMP level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of cyclic AMP measured in a cell is lower than normal." [] synonym: "decreased cellular cAMP accumulation" EXACT [] synonym: "reduced cellular cAMP level" EXACT [] xref: FYPO:0001660 is_a: PHIPO:0001022 ! altered cellular cAMP level is_a: PHIPO:0001035 ! decreased level of substance in cell created_by: alaynecuzick creation_date: 2019-08-17T13:47:28Z [Term] id: PHIPO:0001024 name: increased cellular cAMP level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of cyclic AMP measured in a cell is higher than normal." [] synonym: "increased cAMP accumulation" EXACT [] synonym: "increased cellular cyclic AMP level" EXACT [] xref: FYPO:0001661 is_a: PHIPO:0001022 ! altered cellular cAMP level is_a: PHIPO:0001036 ! increased level of substance in cell created_by: alaynecuzick creation_date: 2019-08-17T13:47:39Z [Term] id: PHIPO:0001025 name: altered protein level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of protein measured in a cell differs from normal. Total protein or a specific protein may be affected." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal protein level" EXACT [] synonym: "altered cellular protein level" EXACT [] xref: FYPO:0000834 is_a: PHIPO:0000944 ! altered level of substance in cell created_by: alaynecuzick creation_date: 2019-08-17T14:21:36Z [Term] id: PHIPO:0001026 name: increased protein level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of protein measured in a cell is higher than normal. Total protein or a specific protein may be affected." [] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. synonym: "increased protein accumulation" RELATED [] xref: FYPO:0000836 is_a: PHIPO:0001025 ! altered protein level is_a: PHIPO:0001036 ! increased level of substance in cell created_by: alaynecuzick creation_date: 2019-08-17T14:23:48Z [Term] id: PHIPO:0001027 name: decreased protein level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of protein measured in a cell is lower than normal. Total protein or a specific protein may be affected." [] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. synonym: "decreased protein accumulation" RELATED [] synonym: "reduced protein level" EXACT [] xref: FYPO:0000835 is_a: PHIPO:0001025 ! altered protein level is_a: PHIPO:0001035 ! decreased level of substance in cell created_by: alaynecuzick creation_date: 2019-08-17T14:23:55Z [Term] id: PHIPO:0001028 name: abolished protein localization to plasma membrane namespace: single_species_phenotype def: "A single organism phenotype in which the localization of a protein to the plasma membrane is abolished (GO:0072659)." [] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: PHIPO:0000245 ! abolished protein localization created_by: alaynecuzick creation_date: 2019-08-17T14:51:09Z [Term] id: PHIPO:0001029 name: abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm namespace: single_species_phenotype def: "A single organism phenotype in which the localization of a protein to the plasma membrane is abolished, and the protein is present in the cytoplasm instead." [] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. xref: FYPO:0002126 is_a: PHIPO:0001028 ! abolished protein localization to plasma membrane created_by: alaynecuzick creation_date: 2019-08-17T14:55:21Z [Term] id: PHIPO:0001030 name: altered cellular toxin level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of toxin measured in a cell differs from normal." [] is_a: PHIPO:0000944 ! altered level of substance in cell created_by: alaynecuzick creation_date: 2019-09-06T10:49:07Z [Term] id: PHIPO:0001031 name: decreased cellular toxin level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of toxin measured in a cell is lower than normal." [] is_a: PHIPO:0001030 ! altered cellular toxin level is_a: PHIPO:0001035 ! decreased level of substance in cell created_by: alaynecuzick creation_date: 2019-09-06T10:49:58Z [Term] id: PHIPO:0001032 name: decreased level of pyocyanin namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of pyocyanin measured in a cell is lower than normal." [] is_a: PHIPO:0001031 ! decreased cellular toxin level created_by: alaynecuzick creation_date: 2019-09-06T10:50:37Z [Term] id: PHIPO:0001033 name: pyocyanin absent from cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of pyocyanin measured in a cell is too low to detect." [] is_a: PHIPO:0001034 ! substance absent from cell created_by: alaynecuzick creation_date: 2019-09-06T10:51:03Z [Term] id: PHIPO:0001034 name: substance absent from cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of a specific substance measured in a cell is too low to detect." [] xref: FYPO:0001888 is_a: PHIPO:0001035 ! decreased level of substance in cell created_by: alaynecuzick creation_date: 2019-09-06T11:00:13Z [Term] id: PHIPO:0001035 name: decreased level of substance in cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of a specific substance measured in a cell is lower than normal." [] synonym: "reduced level of substance in cell" EXACT [] xref: FYPO:0000991 is_a: PHIPO:0000944 ! altered level of substance in cell created_by: alaynecuzick creation_date: 2019-09-06T11:04:53Z [Term] id: PHIPO:0001036 name: increased level of substance in cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of a specific substance measured in a cell is higher than normal." [] synonym: "increased accumulation of substance in cell" RELATED [] xref: FYPO:0000990 is_a: PHIPO:0000944 ! altered level of substance in cell created_by: alaynecuzick creation_date: 2019-09-06T11:05:35Z [Term] id: PHIPO:0001037 name: increased cellular toxin level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of toxin measured in a cell is higher than normal." [] is_a: PHIPO:0001030 ! altered cellular toxin level is_a: PHIPO:0001036 ! increased level of substance in cell created_by: alaynecuzick creation_date: 2019-09-06T11:24:02Z [Term] id: PHIPO:0001038 name: normal level of substance in cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of a specific substance measured in a cell is normal (i.e. indistinguishable from wild type)." [] xref: FYPO:0001076 is_a: PHIPO:0000403 ! normal cell phenotype created_by: alaynecuzick creation_date: 2019-09-06T11:34:52Z [Term] id: PHIPO:0001039 name: normal cellular toxin level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of toxin measured in a cell is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001038 ! normal level of substance in cell created_by: alaynecuzick creation_date: 2019-09-06T11:55:23Z [Term] id: PHIPO:0001040 name: obsolete decreased level of a substance in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of a specific substance measured in a pathogen or host cell is lower than normal." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-06T12:27:07Z [Term] id: PHIPO:0001041 name: obsolete increased level of a substance in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of a specific substance measured in a pathogen or host cell is higher than normal." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-06T12:27:17Z [Term] id: PHIPO:0001042 name: obsolete substance absent in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of a specific substance measured in a pathogen or host cell is too low to detect." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-06T12:27:54Z [Term] id: PHIPO:0001043 name: level of pathogen produced toxin within host phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, which affects the level of pathogen produced toxin during host infection." [] is_a: PHIPO:0001197 ! level of pathogen produced substance within host phenotype created_by: alaynecuzick creation_date: 2019-09-06T12:30:03Z [Term] id: PHIPO:0001044 name: obsolete protein absent in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of protein measured in a pathogen or host cell is too low to detect. Total protein or a specific protein may be affected." [] xref: FYPO:0001983 is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-06T12:39:49Z [Term] id: PHIPO:0001045 name: decreased level of pathogen produced toxin within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen produced toxin usually present during infection is lower than normal." [] is_a: PHIPO:0001043 ! level of pathogen produced toxin within host phenotype created_by: alaynecuzick creation_date: 2019-09-06T12:44:12Z [Term] id: PHIPO:0001046 name: increased level of pathogen produced toxin within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen produced toxin usually present during infection is higher than normal." [] is_a: PHIPO:0001043 ! level of pathogen produced toxin within host phenotype created_by: alaynecuzick creation_date: 2019-09-06T12:44:20Z [Term] id: PHIPO:0001047 name: pathogen toxin within host absent namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the pathogen produced toxin usually present during infection is absent or at a level too low to detect." [] synonym: "absence of pathogen toxin within host" RELATED [] is_a: PHIPO:0001045 ! decreased level of pathogen produced toxin within host created_by: alaynecuzick creation_date: 2019-09-06T12:45:24Z [Term] id: PHIPO:0001048 name: obsolete normal level of substance phenotype in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of a specific substance measured in a pathogen or host cell is normal (i.e. indistinguishable from wild type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-06T12:46:32Z [Term] id: PHIPO:0001049 name: unicellular colony shape phenotype namespace: single_species_phenotype def: "A single species population phenotype affecting the shape of a colony of unicellular individuals." [] comment: Note that colony morphology terms are not used in PHIPO to annotate filamentous-form colonies because these phenotypes can be related to specific growth terms for hyphal colony morphology please search for PHIPO:0001214 (hyphal growth phenotype). For unicellular colony morphology at the usual resolution it is usually not possible to make any statement about an individual. For dimorphic pathogens these terms are suitable for yeast-form colony phenotypes. synonym: "colony morphology phenotype" BROAD [] is_a: PHIPO:0001208 ! unicellular colony morphology phenotype created_by: alaynecuzick creation_date: 2019-09-10T13:26:05Z [Term] id: PHIPO:0001051 name: abnormal unicellular colony shape namespace: single_species_phenotype alt_id: PHIPO:0001050 def: "A single species phenotype where the shape of a colony of unicellular individuals is abnormal." [] comment: Note that colony morphology terms are not used in PHIPO to annotate filamentous-form colonies because these phenotypes can be related to specific growth terms for hyphal colony morphology please search for PHIPO:0001214 (hyphal growth phenotype). For unicellular colony morphology at the usual resolution it is usually not possible to make any statement about an individual. For dimorphic pathogens these terms are suitable for yeast-form colony phenotypes. synonym: "abnormal colony morphology" BROAD [] is_a: PHIPO:0001049 ! unicellular colony shape phenotype created_by: alaynecuzick creation_date: 2019-09-10T13:29:47Z [Term] id: PHIPO:0001052 name: hyper-smooth unicellular colony shape namespace: single_species_phenotype def: "A single species colony shape phenotype where the colony is smoother than normal." [] comment: Note that colony morphology terms are not used in PHIPO to annotate filamentous-form colonies because these phenotypes can be related to specific growth terms for hyphal colony morphology please search for PHIPO:0001214 (hyphal growth phenotype). For unicellular colony morphology at the usual resolution it is usually not possible to make any statement about an individual. For dimorphic pathogens these terms are suitable for yeast-form colony phenotypes. synonym: "hyper-smooth colony morphology" RELATED [] is_a: PHIPO:0001051 ! abnormal unicellular colony shape created_by: alaynecuzick creation_date: 2019-09-10T13:32:18Z [Term] id: PHIPO:0001053 name: hyper-rugose unicellular colony shape namespace: single_species_phenotype def: "A single species phenotype where the shape of a colony of unicellular individuals is more rugose (wrinkled; corrugated) than normal." [] comment: Note that colony morphology terms are not used in PHIPO to annotate filamentous-form colonies because these phenotypes can be related to specific growth terms for hyphal colony morphology please search for PHIPO:0001214 (hyphal growth phenotype). For unicellular colony morphology at the usual resolution it is usually not possible to make any statement about an individual. For dimorphic pathogens these terms are suitable for yeast-form colony phenotypes. synonym: "hyper-rugose colony morphology" RELATED [] is_a: PHIPO:0001051 ! abnormal unicellular colony shape created_by: alaynecuzick creation_date: 2019-09-10T13:32:45Z [Term] id: PHIPO:0001055 name: obsolete increased size of colony namespace: single_species_phenotype alt_id: PHIPO:0000179 def: "A single species colony morphology phenotype where the size of the population is increased." [] synonym: "increased filamentous growth" RELATED [] synonym: "increased size of filamentous colony" RELATED [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-10T13:37:47Z [Term] id: PHIPO:0001057 name: normal unicellular colony shape namespace: single_species_phenotype alt_id: PHIPO:0001065 def: "A single species phenotype where the shape of a colony of unicellular individuals is normal (indistinguishable from wild type)." [] comment: Note that colony morphology terms are not used in PHIPO to annotate filamentous-form colonies because these phenotypes can be related to specific growth terms for hyphal colony morphology please search for PHIPO:0001214 (hyphal growth phenotype). For unicellular colony morphology at the usual resolution it is usually not possible to make any statement about an individual. For dimorphic pathogens these terms are suitable for yeast-form colony phenotypes. synonym: "normal colony morphology" BROAD [] synonym: "normal shape of colony" EXACT [] is_a: PHIPO:0001049 ! unicellular colony shape phenotype created_by: alaynecuzick creation_date: 2019-09-13T10:53:42Z [Term] id: PHIPO:0001058 name: normal rugose unicellular colony shape namespace: single_species_phenotype def: "A single species phenotype where the shape of a colony of unicellular individuals is as rugose (wrinkled; corrugated) as normal (indistinguishable from wild type)." [] comment: Note that colony morphology terms are not used in PHIPO to annotate filamentous-form colonies because these phenotypes can be related to specific growth terms for hyphal colony morphology please search for PHIPO:0001214 (hyphal growth phenotype). For unicellular colony morphology at the usual resolution it is usually not possible to make any statement about an individual. For dimorphic pathogens these terms are suitable for yeast-form colony phenotypes. synonym: "normal rugose colony morphology" RELATED [] is_a: PHIPO:0001057 ! normal unicellular colony shape created_by: alaynecuzick creation_date: 2019-09-10T13:40:49Z [Term] id: PHIPO:0001059 name: increased level of pyocyanin namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of pyocyanin measured in a cell is higher than normal." [] is_a: PHIPO:0001037 ! increased cellular toxin level created_by: alaynecuzick creation_date: 2019-09-11T13:06:36Z [Term] id: PHIPO:0001060 name: altered RNA level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of RNA measured in a cell differs from normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal RNA level" EXACT [] synonym: "altered cellular RNA level" EXACT [] synonym: "altered transcript level" EXACT [] xref: FYPO:0000824 is_a: PHIPO:0000944 ! altered level of substance in cell created_by: alaynecuzick creation_date: 2019-09-11T13:14:54Z [Term] id: PHIPO:0001061 name: decreased RNA level namespace: single_species_phenotype def: "A singe species cell phenotype in which the amount of RNA measured in a cell is lower than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased cellular RNA level" EXACT [] synonym: "decreased transcript level" EXACT [] synonym: "reduced RNA level" EXACT [] xref: FYPO:0000826 is_a: PHIPO:0001035 ! decreased level of substance in cell is_a: PHIPO:0001060 ! altered RNA level created_by: alaynecuzick creation_date: 2019-09-11T13:18:59Z [Term] id: PHIPO:0001062 name: increased RNA level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of RNA measured in a cell is higher than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased cellular RNA level" EXACT [] synonym: "increased RNA accumulation" RELATED [] synonym: "increased transcript level" EXACT [] xref: FYPO:0001890 is_a: PHIPO:0001036 ! increased level of substance in cell is_a: PHIPO:0001060 ! altered RNA level created_by: alaynecuzick creation_date: 2019-09-11T13:22:53Z [Term] id: PHIPO:0001063 name: RNA absent from cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of RNA measured in a cell is too low to detect. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] synonym: "transcripts absent from cell" EXACT [] synonym: "undetectable cellular RNA level" EXACT [] xref: FYPO:0001889 is_a: PHIPO:0001034 ! substance absent from cell is_a: PHIPO:0001060 ! altered RNA level created_by: alaynecuzick creation_date: 2019-09-11T13:26:30Z [Term] id: PHIPO:0001064 name: normal RNA level namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of RNA measured in a cell is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] synonym: "normal cellular RNA level" EXACT [] synonym: "normal mRNA level" NARROW [] synonym: "normal transcript level" EXACT [] xref: FYPO:0000840 is_a: PHIPO:0001038 ! normal level of substance in cell created_by: alaynecuzick creation_date: 2019-09-11T13:30:41Z [Term] id: PHIPO:0001067 name: obsolete pathogen host interaction organism level phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that is observed at the level of an individual organism (eg a worm host)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-20T11:03:58Z [Term] id: PHIPO:0001068 name: survival of host organism with pathogen namespace: pathogen_host_interaction_phenotype def: "A host organism viability phenotype where the host organism survives in the presence of the pathogen." [] synonym: "viable host organism with pathogen" RELATED [] is_a: PHIPO:0001070 ! host organism viability with pathogen phenotype created_by: alaynecuzick creation_date: 2019-09-20T11:06:42Z [Term] id: PHIPO:0001069 name: death of host organism with pathogen namespace: pathogen_host_interaction_phenotype def: "A host organism viability phenotype where the host organism death is accelerated by the pathogen." [] synonym: "host kill assay" RELATED [] synonym: "inviable host organism with pathogen" RELATED [] synonym: "pathogen induced death of host organism" RELATED [] synonym: "precocious senescence" RELATED [] is_a: PHIPO:0001070 ! host organism viability with pathogen phenotype created_by: alaynecuzick creation_date: 2019-09-20T11:07:02Z [Term] id: PHIPO:0001070 name: host organism viability with pathogen phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction organism level phenotype which affects the viability of an individual host organism in the presence of a pathogen." [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2019-09-20T11:19:37Z [Term] id: PHIPO:0001071 name: obsolete viable host organism with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction organism viability phenotype where a host organism is viable in the presence of a pathogen." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-20T11:20:10Z [Term] id: PHIPO:0001072 name: obsolete inviable host organism with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction organism viability phenotype where a host organism is inviable in the presence of a pathogen." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-20T11:20:25Z [Term] id: PHIPO:0001074 name: sensitive to iron ion starvation namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to iron ion starvation. Typically, individuals or populations are deemed sensitive to a stress if they stop growing (and may die) when exposed to the stress at an intensity that allows an individual or population of wild type cell(s) to grow and divide." [] synonym: "hypersensitive to iron ion starvation" EXACT [] synonym: "sensitive to iron ion depletion" EXACT [] synonym: "sensitive to iron ion deprivation" EXACT [] synonym: "sensitive to iron starvation" EXACT [] xref: FYPO:0002015 is_a: PHIPO:0001098 ! sensitive to stress created_by: alaynecuzick creation_date: 2019-09-27T09:51:47Z [Term] id: PHIPO:0001075 name: auxotrophic growth namespace: single_species_phenotype def: "A growth phenotype which describes an individual or a population of organisms which requires a particular organic compound, which is not required by a wild-type for its growth. Auxotrophy usually results from a cell's inability to synthesize the compound." [] synonym: "auxotrophy phenotype" RELATED [] xref: FYPO:0000128 is_a: PHIPO:0001216 ! nutrient phenotype created_by: alaynecuzick creation_date: 2019-09-27T10:01:40Z [Term] id: PHIPO:0001076 name: growth auxotrophic for lysine namespace: single_species_phenotype def: "A growth phenotype which describes an individual or a population of organisms which requires lysine for growth. Auxotrophy usually results from a cell's inability to synthesize the compound." [] xref: FYPO:0000039 is_a: PHIPO:0001075 ! auxotrophic growth created_by: alaynecuzick creation_date: 2019-09-27T10:02:07Z [Term] id: PHIPO:0001077 name: decreased cellular melanin accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of melanin in a cell is decreased." [] is_a: PHIPO:0000288 ! decreased cellular pigment accumulation created_by: alaynecuzick creation_date: 2019-09-27T10:16:39Z [Term] id: PHIPO:0001078 name: absence of cellular melanin accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of melanin in a cell is absent." [] synonym: "albino" RELATED [] synonym: "non-pigmented" RELATED [] is_a: PHIPO:0001077 ! decreased cellular melanin accumulation created_by: alaynecuzick creation_date: 2019-09-27T10:17:08Z [Term] id: PHIPO:0001079 name: obsolete pathogen host interaction pigment phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction organism level phenotype affecting the deposition or aggregation of coloring matter in a cell." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-09-27T11:17:57Z [Term] id: PHIPO:0001080 name: altered pathogen pigment accumulation within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the accumulation of pathogen pigmentation (coloring matter) usually present during infection differs from normal." [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2019-09-27T11:19:13Z [Term] id: PHIPO:0001081 name: absence of melanin accumulation in pathogen asexual spore within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction, in which the accumulation of melanin within a pathogen asexual spore, usually present during infection, is absent." [] synonym: "absence of melanin accumulation in pathogen conidia with host" EXACT [] is_a: PHIPO:0001080 ! altered pathogen pigment accumulation within host created_by: alaynecuzick creation_date: 2019-09-27T11:20:21Z [Term] id: PHIPO:0001083 name: host defense-induced callose deposition present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host produced callose deposition usually present during infection is normal (i.e. indistinguishable from wild type)." [] comment: GO:0052542 synonym: "pathogen induced callose deposition in host present" EXACT [] synonym: "pathogen-induced callose deposition in host present" EXACT [] synonym: "presence of pathogen induced callose deposition in host" RELATED [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2019-10-01T09:09:20Z [Term] id: PHIPO:0001084 name: increased unicellular population growth rate namespace: single_species_phenotype def: "A single species population growth phenotype where the rate of the increase in the number of unicellular organisms in the population (i.e organismal growth and reproduction) is faster than normal." [] xref: FYPO:0000636 is_a: PHIPO:0000975 ! increased unicellular population growth created_by: alaynecuzick creation_date: 2019-10-01T09:17:27Z [Term] id: PHIPO:0001085 name: decreased unicellular population growth rate namespace: single_species_phenotype def: "A single species population growth phenotype where the rate of the increase in the number of unicellular organisms in the population (i.e organismal growth and reproduction) is slower than normal." [] xref: FYPO:0001355 is_a: PHIPO:0000974 ! decreased unicellular population growth created_by: alaynecuzick creation_date: 2019-10-01T09:21:13Z [Term] id: PHIPO:0001086 name: abnormal cellular component assembly namespace: single_species_phenotype def: "A single species cellular process phenotype in which any process of cellular component assembly at the cellular level is abnormal." [] xref: FYPO:0000336 is_a: PHIPO:0000400 ! abnormal cellular component organization created_by: alaynecuzick creation_date: 2019-10-01T09:36:55Z [Term] id: PHIPO:0001088 name: decreased rate of hyphae formation namespace: single_species_phenotype def: "An individual organism growth phenotype in which the rate, or speed, of hyphae formation is decreased." [] synonym: "slow hyphae formation" EXACT [] is_a: PHIPO:0001212 ! decreased hyphal growth created_by: alaynecuzick creation_date: 2019-10-01T09:41:16Z [Term] id: PHIPO:0001089 name: decreased rate of germination tube formation namespace: single_species_phenotype def: "An individual organism growth phenotype in which the rate, or speed, of germ tube formation is decreased resulting in decreased hyphal growth." [] synonym: "slow germination tube formation" EXACT [] is_a: PHIPO:0001212 ! decreased hyphal growth created_by: alaynecuzick creation_date: 2019-10-01T09:42:41Z [Term] id: PHIPO:0001090 name: abolished protein secretion namespace: single_species_phenotype def: "A single organism localization phenotype in which a protein is not exported via the secretory pathway." [] is_a: PHIPO:0000245 ! abolished protein localization created_by: alaynecuzick creation_date: 2019-10-01T09:56:51Z [Term] id: PHIPO:0001091 name: abolished chitinase activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which a chitinase activity is absent." [] synonym: "chitinase activity absent" EXACT [] is_a: PHIPO:0000435 ! abolished catalytic activity created_by: alaynecuzick creation_date: 2019-10-01T13:15:29Z [Term] id: PHIPO:0001092 name: increased chitin level in asexual spore namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of chitin measured in the spore is higher than normal" [] synonym: "increased chitin level in conidia" EXACT [] is_a: PHIPO:0001036 ! increased level of substance in cell is_a: PHIPO:0001094 ! abnormal localization created_by: alaynecuzick creation_date: 2019-10-01T13:26:59Z [Term] id: PHIPO:0001094 name: abnormal localization namespace: single_species_phenotype def: "A single species phenotype where the localization of a structure or substance in a cell is abnormal." [] is_a: PHIPO:0000235 ! localization phenotype created_by: alaynecuzick creation_date: 2019-10-01T13:35:05Z [Term] id: PHIPO:0001095 name: abnormal localization of chitin in cell namespace: single_species_phenotype def: "A single organism phenotype in which the localization of chitin in a cell is abnormal. Chitin may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [] synonym: "abnormal chitin deposition" NARROW [] synonym: "abnormal chitin distribution" EXACT [] is_a: PHIPO:0001094 ! abnormal localization created_by: alaynecuzick creation_date: 2019-10-01T13:37:30Z [Term] id: PHIPO:0001096 name: resistance to stress namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to a specific stress. Typically, individuals or populations are deemed resistant to a stress if they grow when exposed to the stress at an intensity at which an individual or population of wild type cell(s) stop growing (and may die)." [] synonym: "resistant to stress" EXACT [] synonym: "stress resistance: increased" EXACT [] xref: FYPO:0002046 is_a: PHIPO:0001217 ! stress phenotype created_by: alaynecuzick creation_date: 2019-10-04T09:18:07Z [Term] id: PHIPO:0001097 name: resistance to cell wall stress namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to a cell wall stress. Typically, individuals or populations are deemed resistant to a stress if they grow when exposed to the stress at an intensity at which an individual or population of wild type cell(s) stop growing (and may die)." [] is_a: PHIPO:0001096 ! resistance to stress created_by: alaynecuzick creation_date: 2019-10-04T09:18:26Z [Term] id: PHIPO:0001098 name: sensitive to stress namespace: single_species_phenotype alt_id: PHIPO:0001073 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to a specific stress. Typically, individuals or populations are deemed sensitive to a stress if they stop growing (and may die) when exposed to the stress at an intensity that allows an individual or population of wild type cell(s) to grow and divide." [] synonym: "hypersensitive to stress" EXACT [] synonym: "sensitive to stress during growth" RELATED [] synonym: "stress resistance: decreased" EXACT [] xref: FYPO:0000304 xref: FYPO:0002549 is_a: PHIPO:0001217 ! stress phenotype created_by: alaynecuzick creation_date: 2019-10-04T09:25:47Z [Term] id: PHIPO:0001099 name: obsolete increased RNA level in a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A cell phenotype in which the amount of RNA measured in a pathogen or host cell is higher than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-10-04T12:30:49Z [Term] id: PHIPO:0001100 name: increased level of pathogen RNA within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen RNA usually present during infection is higher than normal." [] is_a: PHIPO:0001267 ! level of pathogen produced RNA within host phenotype created_by: alaynecuzick creation_date: 2019-10-04T12:31:14Z [Term] id: PHIPO:0001101 name: absence of pathogen asexual sporulation structures within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host where the pathogen asexual sporulation structures are absent." [] synonym: "pycnidia absent within host" RELATED [] is_a: PHIPO:0000469 ! abnormal pathogen asexual sporulation within host created_by: alaynecuzick creation_date: 2019-10-04T12:39:32Z [Term] id: PHIPO:0001102 name: presence of pathogen asexual sporulation structures within host lesion namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of asexual sporulation structures within a host lesion is normal (i.e. indistinguishable from wild type)." [] synonym: "normal number of pycnidia within host" RELATED [] is_a: PHIPO:0000472 ! normal pathogen asexual sporulation within host created_by: alaynecuzick creation_date: 2019-10-04T12:43:45Z [Term] id: PHIPO:0001104 name: increased level of host defense-induced RNA namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host RNA usually present during infection is higher than normal." [] synonym: "increased level of host RNA involved in a pathogen interaction" EXACT [] is_a: PHIPO:0001263 ! host defense-induced RNA level phenotype created_by: alaynecuzick creation_date: 2019-10-07T13:26:33Z [Term] id: PHIPO:0001105 name: gliotoxin absent from cell namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of gliotoxin measured in a cell is too low to detect." [] is_a: PHIPO:0001034 ! substance absent from cell created_by: alaynecuzick creation_date: 2019-10-07T13:29:01Z [Term] id: PHIPO:0001106 name: presence of pathogen host protein-protein interaction namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of one pathogen protein to one host protein is present." [] synonym: "binding present between pathogen protein and host protein" EXACT [] is_a: PHIPO:0000131 ! pathogen host protein-protein interaction phenotype created_by: alaynecuzick creation_date: 2019-10-09T12:33:57Z [Term] id: PHIPO:0001107 name: absence of pathogen host protein-protein interaction namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0000204 def: "A molecular function phenotype in which the binding of one pathogen protein to one host protein is absent." [] synonym: "abolished pathogen host protein-protein interaction" RELATED [] synonym: "binding absent between pathogen protein and host protein" EXACT [] is_a: PHIPO:0000131 ! pathogen host protein-protein interaction phenotype created_by: alaynecuzick creation_date: 2018-10-01T13:31:59Z [Term] id: PHIPO:0001108 name: pathogen host interaction pH phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the pH in a pathogen or host cell or cellular component." [] comment: Note that this term was reinstated from obsolete. is_a: PHIPO:0000510 ! pathogen host interaction cell phenotype created_by: alaynecuzick creation_date: 2019-10-09T12:41:35Z [Term] id: PHIPO:0001109 name: obsolete abnormal pathogen-induced host pH namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host pH value during infection differs from normal." [] synonym: "abnormal pathogen induced host pH" EXACT [] synonym: "altered pathogen induced host pH" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-10-09T12:42:06Z [Term] id: PHIPO:0001110 name: obsolete pathogen-induced decrease in host pH namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the pathogen induces a pH decrease within the host cell or cellular component." [] synonym: "pathogen induced acidification of host" EXACT [] synonym: "pathogen induced decrease in host pH" EXACT [] synonym: "pathogen induced low pH in host" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-10-09T12:42:51Z [Term] id: PHIPO:0001111 name: obsolete pathogen-induced increase in host pH namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the pathogen induces a pH increase within the host cell or cellular component." [] synonym: "pathogen induced alkalinization of host" EXACT [] synonym: "pathogen induced high pH in host" EXACT [] synonym: "pathogen induced increase in host pH" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-10-09T12:43:07Z [Term] id: PHIPO:0001112 name: obsolete normal pH within a pathogen host interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the pH in a pathogen or host cell or cellular component is normal." [] is_obsolete: true created_by: alaynecuzick creation_date: 2019-10-09T12:45:38Z [Term] id: PHIPO:0001113 name: host defense induced acidification in phagolysome present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host induces a pH decrease within the host phagolysome in response to pathogen colonization." [] synonym: "pathogen induced acidification in host phagolysome" EXACT [] synonym: "pathogen induced pH decrease in host phagolysome" EXACT [] is_a: PHIPO:0001108 ! pathogen host interaction pH phenotype created_by: alaynecuzick creation_date: 2019-10-09T12:49:07Z [Term] id: PHIPO:0001114 name: decreased number of pathogen asexual sporulation structures within host lesion namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of asexual sporulation structures within a host lesion is fewer than normal." [] synonym: "reduced number of pycnidia within host" RELATED [] is_a: PHIPO:0000469 ! abnormal pathogen asexual sporulation within host created_by: alaynecuzick creation_date: 2019-10-11T10:55:28Z [Term] id: PHIPO:0001115 name: decreased phosphopantetheinyl transferase activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the observed rate of phosphopantetheinyl transferase activity is decreased." [] is_a: PHIPO:0000436 ! decreased catalytic activity created_by: alaynecuzick creation_date: 2019-10-18T09:13:50Z [Term] id: PHIPO:0001116 name: host immune system signaling pathway pathogen-host interaction phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects a host immune system signaling pathway during pathogen infection." [] synonym: "pathogen modulation of host immune system signaling pathway phenotype" RELATED [] is_a: PHIPO:0001167 ! pathogen modulation of host immune system process phenotype created_by: alaynecuzick creation_date: 2019-10-22T12:26:26Z [Term] id: PHIPO:0001117 name: host immune signaling pathway activated by pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host immune signaling pathway is induced by a pathogen." [] synonym: "host immune signalling pathway activated by pathogen" EXACT [] is_a: PHIPO:0001116 ! host immune system signaling pathway pathogen-host interaction phenotype created_by: alaynecuzick creation_date: 2019-10-22T12:26:58Z [Term] id: PHIPO:0001118 name: abnormal protein modification namespace: single_species_phenotype def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein modification is abnormal. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [] xref: FYPO:0000329 is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2019-11-06T13:01:27Z [Term] id: PHIPO:0001119 name: abnormal protein phosphorylation namespace: single_species_phenotype def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, is abnormal." [] xref: FYPO:0000775 is_a: PHIPO:0001118 ! abnormal protein modification is_a: PHIPO:0001147 ! cellular metabolic process phenotype created_by: alaynecuzick creation_date: 2019-11-06T13:02:19Z [Term] id: PHIPO:0001120 name: decreased protein phosphorylation namespace: single_species_phenotype def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [] xref: FYPO:0001838 is_a: PHIPO:0001119 ! abnormal protein phosphorylation created_by: alaynecuzick creation_date: 2019-11-06T13:02:53Z [Term] id: PHIPO:0001121 name: abnormal sexual reproductive structure development namespace: single_species_phenotype def: "A single species phenotype where the sexual reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals, from their formation to the mature structures is abnormal (GO:0048608)." [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2019-11-06T13:43:30Z [Term] id: PHIPO:0001122 name: decreased number of sexual sporulation structures namespace: single_species_phenotype def: "A single species reproductive phenotype in which the frequency of occurrence of sexual sporulation structures is fewer than normal." [] synonym: "decreased perithecium formation" RELATED [] is_a: PHIPO:0001121 ! abnormal sexual reproductive structure development created_by: alaynecuzick creation_date: 2019-11-06T13:45:40Z [Term] id: PHIPO:0001123 name: viable population namespace: single_species_phenotype def: "An organism population phenotype in which some organisms in the population are viable." [] synonym: "non-essential" RELATED [] synonym: "non-lethal" EXACT [] is_a: PHIPO:0000514 ! population viability phenotype created_by: alaynecuzick creation_date: 2019-12-03T10:47:11Z [Term] id: PHIPO:0001124 name: decreased growth on erucic acid carbon source namespace: single_species_phenotype def: "A growth phenotype which describes the decrease in growth of individuals or populations relative to normal in a medium containing erucic acid as the carbon source." [] is_a: PHIPO:0001216 ! nutrient phenotype created_by: alaynecuzick creation_date: 2019-12-03T10:52:30Z [Term] id: PHIPO:0001125 name: decreased growth on oleic acid carbon source namespace: single_species_phenotype def: "A growth phenotype which describes the decrease in growth of individuals or populations relative to normal in a medium containing oleic acid as the carbon source." [] is_a: PHIPO:0001216 ! nutrient phenotype created_by: alaynecuzick creation_date: 2019-12-03T10:57:47Z [Term] id: PHIPO:0001126 name: decreased growth on palmitic acid carbon source namespace: single_species_phenotype def: "A growth phenotype which describes the decrease in growth of individuals or populations relative to normal in a medium containing palmitic acid as the carbon source." [] is_a: PHIPO:0001216 ! nutrient phenotype created_by: alaynecuzick creation_date: 2019-12-03T10:58:27Z [Term] id: PHIPO:0001127 name: decreased growth on myristic acid carbon source namespace: single_species_phenotype def: "A growth phenotype which describes the decrease in growth of individuals or populations relative to normal in a medium containing myristic acid as the carbon source." [] is_a: PHIPO:0001216 ! nutrient phenotype created_by: alaynecuzick creation_date: 2019-12-03T10:59:32Z [Term] id: PHIPO:0001128 name: effector-mediated suppression of host PAMP-triggered immunity present namespace: pathogen_host_interaction_phenotype def: "A cell signaling pathway phenotype where the molecular pattern-induced host innate immune response signaling pathway is suppressed by a pathogen. (GO:0052034)" [] synonym: "pathogen suppression of host PAMP-triggered immunity" EXACT [] synonym: "suppression of host MAMP-triggered immunity" EXACT [] synonym: "suppression of host PAMP-triggered immunity" EXACT [] synonym: "suppression of host PTI" EXACT [] is_a: PHIPO:0001176 ! effector-mediated immune suppression phenotype created_by: alaynecuzick creation_date: 2019-12-03T11:08:34Z [Term] id: PHIPO:0001130 name: stunted host growth during pathogen colonization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the presence of a pathogen (or symbiont) has resulted in a decreased size of the host organism." [] synonym: "decreased host growth with pathogen" EXACT [] synonym: "decreased host size with pathogen" EXACT [] is_a: PHIPO:0001006 ! abnormal host morphology during pathogen invasion created_by: alaynecuzick creation_date: 2019-12-09T13:45:59Z [Term] id: PHIPO:0001131 name: increased number of host side shoots during pathogen colonization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the presence of a pathogen (or symbiont) has resulted in an increased number of side shoots produced by the host organism." [] synonym: "increased number of host tillers during pathogen colonization" NARROW [] is_a: PHIPO:0001006 ! abnormal host morphology during pathogen invasion created_by: alaynecuzick creation_date: 2019-12-09T13:51:02Z [Term] id: PHIPO:0001132 name: increased size of pathogen vacuoles during host colonization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the size of the pathogen vacuoles are larger than normal during host colonization. This relates to the pathogen colonization of the body, tissues, or cells of the host organism." [] is_a: PHIPO:0000999 ! abnormal pathogen morphology during colonization of host created_by: alaynecuzick creation_date: 2019-12-09T14:04:10Z [Term] id: PHIPO:0001133 name: increased cellular melanin accumulation namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of melanin in a cell is increased." [] is_a: PHIPO:0000287 ! increased cellular pigment accumulation created_by: alaynecuzick creation_date: 2019-12-17T14:27:14Z [Term] id: PHIPO:0001134 name: sensitive to potassium chloride namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to potassium chloride. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] xref: FYPO:0001214 is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2019-12-17T14:30:47Z [Term] id: PHIPO:0001135 name: sensitive to sorbitol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to sorbitol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] xref: FYPO:0000112 is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2019-12-17T14:32:35Z [Term] id: PHIPO:0001136 name: abolished development of asexual reproductive structure namespace: single_species_phenotype def: "A single species phenotype where the asexual reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals, from their formation to the mature structures is abolished (it was present and is now absent) (GO:0048608)." [] synonym: "abolished development of conidiophore" EXACT [] is_a: PHIPO:0000121 ! abnormal asexual reproductive structure development created_by: alaynecuzick creation_date: 2019-12-18T09:31:20Z [Term] id: PHIPO:0001137 name: increased number of hyphal septa namespace: single_species_phenotype def: "An individual organism cellular process phenotype in which the number of septa produced during hyphae formation is increased." [] comment: This phenotype is related to division rather than growth and usually indicates that hyphae with more septa have an increased number of smaller individual cells. If experiments also indicate an increase or reduction in hyphal growth please coannotate in the hyphal growth branch. is_a: PHIPO:0000415 ! abnormal subcellular component is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2019-12-18T09:34:09Z [Term] id: PHIPO:0001138 name: decreased number of asexual reproductive structures namespace: single_species_phenotype def: "A single species phenotype where the frequency of occurrence of asexual reproductive structures is decreased." [] synonym: "decreased number of conidiophores" EXACT [] is_a: PHIPO:0000121 ! abnormal asexual reproductive structure development created_by: alaynecuzick creation_date: 2019-12-19T09:51:13Z [Term] id: PHIPO:0001139 name: decreased number of septum in asexual spore namespace: single_species_phenotype def: "A single species phenotype where the frequency of occurrence of septum within an asexual spore is decreased." [] synonym: "decreased number of conidial septum" EXACT [] synonym: "decreased number of septum in conidia" EXACT [] is_a: PHIPO:0000127 ! abnormal asexual spore morphology is_a: PHIPO:0001137 ! increased number of hyphal septa created_by: alaynecuzick creation_date: 2020-01-07T13:11:13Z [Term] id: PHIPO:0001140 name: host PAMP-triggered immunity signaling activated by pathogen present namespace: pathogen_host_interaction_phenotype def: "A cell signaling pathway phenotype where the host pattern recognition receptor signaling pathway is directly induced by a pathogen. This can include any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to a pathogen-derived physiological ligand. PRR ligands are usually referred to as pathogen-associated molecular pattern (PAMPs) or microbe-associated molecular pattern (MAMPs), structures conserved among microbial species (GO:0002221)." [] synonym: "activation of host MAMP-triggered immunity signaling" EXACT [] synonym: "activation of host PAMP-triggered immunity signaling" EXACT [] synonym: "activation of host PRR signalling pathway" BROAD [] synonym: "activation of host PTI signaling" EXACT [] synonym: "host PAMP-triggered immunity signalling activated by pathogen" EXACT [] synonym: "host PTI signaling activated by pathogen" EXACT [] synonym: "pathogen induced host MAP kinase activity" RELATED [] is_a: PHIPO:0001117 ! host immune signaling pathway activated by pathogen is_a: PHIPO:0001246 ! host PAMP-triggered immunity activated by pathogen present created_by: alaynecuzick creation_date: 2020-01-28T11:29:52Z [Term] id: PHIPO:0001141 name: obsolete host effector triggered immunity signaling induced hypersensitive response activated by pathogen namespace: pathogen_host_interaction_phenotype def: "A cell signaling pathway phenotype where the host effector-triggered immunity signaling pathway is induced by a pathogen to activate a plant hypersensitive response and induce necrosis." [] synonym: "activation of host effector-triggered immunity inducing HR" EXACT [] synonym: "activation of host ETI" BROAD [] synonym: "activation of host ETI inducing HR" EXACT [] synonym: "activation of host ETI inducing PCD" BROAD [] synonym: "activation of host ETI signalling pathway inducing HR" EXACT [] synonym: "host effector triggered immunity signalling induced hypersensitive response activated by pathogen" EXACT [] synonym: "host ETI signalling induced HR activated by pathogen" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-01-28T11:36:13Z [Term] id: PHIPO:0001142 name: normal pathogen protein localization to host chloroplast namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of a pathogen protein to the host chloroplast is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001175 ! normal pathogen protein localization within host created_by: alaynecuzick creation_date: 2020-01-28T12:05:46Z [Term] id: PHIPO:0001143 name: abolished pathogen protein localization to host chloroplast namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the localization of a pathogen protein to the host chloroplast is abolished (i.e.the protein was localized to the host chloroplast and now is not)." [] is_a: PHIPO:0000246 ! abolished pathogen protein localization within host created_by: alaynecuzick creation_date: 2020-01-28T12:13:25Z [Term] id: PHIPO:0001144 name: decreased level of host defense-related RNA involved in a pathogen interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host defense-related RNA usually present during infection is lower than normal." [] synonym: "decreased level of host defense related RNA involved in a pathogen interaction" EXACT [] is_a: PHIPO:0001174 ! decreased level of host defense-induced RNA created_by: alaynecuzick creation_date: 2020-01-28T12:40:16Z [Term] id: PHIPO:0001145 name: effector-mediated suppression of host effector triggered immunity present namespace: pathogen_host_interaction_phenotype def: "A phenotype where the process of host tissue cell death causing a host lesion initially induced by the host activating its own hypersensitive response in defense, is subsequently suppressed by a pathogen effector." [] synonym: "pathogen suppression of host effector triggered immunity" EXACT [] synonym: "pathogen suppression of host ETI" EXACT [] synonym: "suppression of host effector triggered immunity" EXACT [] synonym: "suppression of host ETI" EXACT [] is_a: PHIPO:0000182 ! absence of host-defense induced lesion by host hypersensitive response is_a: PHIPO:0001176 ! effector-mediated immune suppression phenotype created_by: alaynecuzick creation_date: 2020-03-04T12:47:38Z [Term] id: PHIPO:0001147 name: cellular metabolic process phenotype namespace: single_species_phenotype def: "A single organism phenotype that affects the chemical reactions and pathways by which individual cells transform chemical substances. (GO:0044237)" [] synonym: "cellular metabolism phenotype" EXACT [] is_a: PHIPO:0000492 ! metabolic process phenotype is_a: PHIPO:0000929 ! abnormal cellular process created_by: alaynecuzick creation_date: 2020-03-04T13:53:21Z [Term] id: PHIPO:0001148 name: unaltered reactive oxygen species production namespace: single_species_phenotype def: "A single species metabolic cellular process phenotype in which the formation of reactive oxygen species (any molecules or ions formed by the incomplete one-electron reduction of oxygen) is unaltered.(GO:1903409)" [] synonym: "normal reactive oxygen species production" EXACT [] synonym: "normal ROS production" EXACT [] synonym: "unaltered ROS production" EXACT [] is_a: PHIPO:0001147 ! cellular metabolic process phenotype created_by: alaynecuzick creation_date: 2020-03-04T13:57:18Z [Term] id: PHIPO:0001149 name: decreased reactive oxygen species production namespace: single_species_phenotype def: "A single species metabolic cellular process phenotype in which the formation of reactive oxygen species (any molecules or ions formed by the incomplete one-electron reduction of oxygen) is decreased.(GO:1903409)" [] synonym: "decreased reactive oxygen species production" EXACT [] synonym: "decreased ROS production" EXACT [] synonym: "reduced reactive oxygen species production" EXACT [] synonym: "reduced ROS production" EXACT [] is_a: PHIPO:0001147 ! cellular metabolic process phenotype created_by: alaynecuzick creation_date: 2020-03-04T14:03:31Z [Term] id: PHIPO:0001150 name: abnormal spatial extent of reactive oxygen species production namespace: single_species_phenotype def: "A single species localization phenotype in which ROS are produced over a different portion of the cell than normal." [] synonym: "abnormal spatial extent of ROS production" EXACT [] is_a: PHIPO:0001094 ! abnormal localization created_by: alaynecuzick creation_date: 2020-03-04T14:11:20Z [Term] id: PHIPO:0001151 name: normal host size during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A host morphology phenotype where the size of the host is normal (indistinguishable from wild type) during pathogen invasion." [] is_a: PHIPO:0001005 ! normal host morphology during pathogen invasion created_by: alaynecuzick creation_date: 2020-03-04T14:21:48Z [Term] id: PHIPO:0001152 name: increased host membrane blebbing during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the host plasma membrane has increased blebbing during pathogen invasion." [] synonym: "increased host membrane blebbing during symbiont invasion" EXACT [] is_a: PHIPO:0001006 ! abnormal host morphology during pathogen invasion created_by: alaynecuzick creation_date: 2020-03-04T14:27:03Z [Term] id: PHIPO:0001153 name: hyphal hyper branching namespace: single_species_phenotype def: "A single species cell morphology phenotype in which fungal hyphae form an increased number of branches." [] synonym: "increased branching of hyphae" EXACT [] synonym: "increased hyphal branching" EXACT [] is_a: PHIPO:0001205 ! abnormal filament morphology created_by: alaynecuzick creation_date: 2020-03-04T14:33:49Z [Term] id: PHIPO:0001154 name: decreased pathogen chitin fragment binding namespace: single_species_phenotype def: "A single species pathogen molecular function phenotype in which pathogen chitin fragment binding by a pathogen gene product is decreased." [] is_a: PHIPO:0000423 ! decreased carbohydrate binding created_by: alaynecuzick creation_date: 2020-03-10T09:51:20Z [Term] id: PHIPO:0001155 name: decreased level of pathogen reactive oxygen species production within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen produced reactive oxygen species (ROS) usually present during infection is lower than normal." [] synonym: "decreased level of pathogen ROS production with host" EXACT [] is_a: PHIPO:0001197 ! level of pathogen produced substance within host phenotype created_by: alaynecuzick creation_date: 2020-03-10T11:33:08Z [Term] id: PHIPO:0001156 name: increased level of pathogen reactive oxygen species production within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen produced reactive oxygen species (ROS) usually present during infection is higher than normal." [] synonym: "increased level of pathogen ROS production with host" EXACT [] is_a: PHIPO:0001197 ! level of pathogen produced substance within host phenotype created_by: alaynecuzick creation_date: 2020-03-10T11:35:08Z [Term] id: PHIPO:0001157 name: obsolete unaltered pathogen reactive oxygen species production within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction metabolic cellular process phenotype in which the formation of reactive oxygen species (any molecules or ions formed by the incomplete one-electron reduction of oxygen) by the pathogen is unaltered within the host.(GO:1903409)" [] synonym: "normal pathogen ROS production within host" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-03-10T11:35:41Z [Term] id: PHIPO:0001159 name: pathogen tissue to tissue migration within host phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype which affects the directional tissue to tissue movement of the pathogen within the host organism (GO:0044001)." [] is_a: PHIPO:0000332 ! pathogen colonization of host phenotype created_by: alaynecuzick creation_date: 2020-03-27T18:25:20Z [Term] id: PHIPO:0001160 name: abolished pathogen tissue to tissue migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the ability of the pathogen to move directionally from tissue to tissue within the host organism is abolished (pathogen migration was present within the host and is now absent)." [] is_a: PHIPO:0001159 ! pathogen tissue to tissue migration within host phenotype created_by: alaynecuzick creation_date: 2020-03-27T18:30:00Z [Term] id: PHIPO:0001161 name: host defense-induced phenolic compound absent namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host phenolic compounds usually present during infection are absent or at a level too low to detect." [] comment: decreased level of CHEBI:33853 in host during GO:051702 interaction with symbiont synonym: "absence of pathogen induced host phenolic compound" RELATED [] synonym: "pathogen induced host phenolic compound absent" EXACT [] synonym: "pathogen-induced host phenolic compound absent" EXACT [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2020-03-27T18:36:56Z [Term] id: PHIPO:0001162 name: obsolete host reproductive phenotype induced by pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects the host reproductive process within the host when a pathogen is present. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms (GO:0000003)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-03-30T15:14:51Z [Term] id: PHIPO:0001163 name: obsolete pathogen host interaction reproductive phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype which affects either the pathogen or host reproductive process. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms (GO:0000003)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2020-03-30T15:16:04Z [Term] id: PHIPO:0001164 name: obsolete abnormal host reproductive structure development induced by pathogen namespace: pathogen_host_interaction_phenotype def: "A host reproductive phenotype with pathogen where the process of host reproductive development is abnormal (GO:0048608)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-03-30T15:17:25Z [Term] id: PHIPO:0001165 name: abnormal host seed development induced by pathogen namespace: pathogen_host_interaction_phenotype def: "A host reproductive phenotype with pathogen where the process of host seed development is abnormal (GO:0048316)." [] synonym: "abnormal host grain development with pathogen" EXACT [] is_a: PHIPO:0001250 ! abnormal host structure induced by pathogen created_by: alaynecuzick creation_date: 2020-03-30T15:17:44Z [Term] id: PHIPO:0001166 name: absence of host seed development induced by pathogen namespace: pathogen_host_interaction_phenotype def: "A host reproductive phenotype with pathogen where the process of host seed development is absent (GO:0048316)." [] synonym: "host grain development absent with pathogen" EXACT [] is_a: PHIPO:0001165 ! abnormal host seed development induced by pathogen created_by: alaynecuzick creation_date: 2020-03-30T15:18:09Z [Term] id: PHIPO:0001167 name: pathogen modulation of host immune system process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects a host immune system process during pathogen infection (GO:0002376)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0001173 ! pathogen modulation of host process phenotype created_by: alaynecuzick creation_date: 2020-04-27T16:23:38Z [Term] id: PHIPO:0001168 name: presence of pathogen inhibition of host immune response protease namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host immune response protease activity is inhibited by the pathogen." [] synonym: "inhibition of host immune response serine-type peptidase activity present" EXACT [] is_a: PHIPO:0001167 ! pathogen modulation of host immune system process phenotype created_by: alaynecuzick creation_date: 2020-04-27T16:38:17Z [Term] id: PHIPO:0001173 name: pathogen modulation of host process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which a pathogen effects a change in the structure or processes of its host organism (GO:0044003)." [] is_a: PHIPO:0000510 ! pathogen host interaction cell phenotype created_by: alaynecuzick creation_date: 2020-05-12T11:06:22Z [Term] id: PHIPO:0001174 name: decreased level of host defense-induced RNA namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host RNA usually present during infection is lower than normal." [] synonym: "decreased level of host RNA involved in a pathogen interaction" EXACT [] is_a: PHIPO:0001263 ! host defense-induced RNA level phenotype created_by: alaynecuzick creation_date: 2020-05-12T13:21:58Z [Term] id: PHIPO:0001175 name: normal pathogen protein localization within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the localization of a pathogen protein in a host cell is normal." [] is_a: PHIPO:0000236 ! pathogen host interaction localization phenotype created_by: alaynecuzick creation_date: 2020-05-13T13:50:08Z [Term] id: PHIPO:0001176 name: effector-mediated immune suppression phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype dependent on an interaction between a pathogen effector and a host process in order for the pathogen to suppress the host immune system. An effector is an entity derived from a pathogenic or non-pathogenic species that either activates or suppresses host defenses or other host responses." [] is_a: PHIPO:0000280 ! pathogen effector mediated modulation of host immune system process created_by: alaynecuzick creation_date: 2020-05-13T15:00:47Z [Term] id: PHIPO:0001179 name: infective ability phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the infective ability of a pathogen during attempted colonization of a host." [] comment: For use in the annotation extension infective ability. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2020-06-01T13:19:23Z [Term] id: PHIPO:0001180 name: absence of effector-independent host hypersensitive response namespace: single_species_phenotype alt_id: PHIPO:0001181 def: "A single species phenotype where the immune system process of host tissue hypersensitive response is absent in a pathogen effector-independant manner. (i.e. an alteration within the host does not activate the hypersensitive response in the absence of a pathogen)." [] subset: host_phenotype synonym: "abolished effector-independent host hypersensitive response" RELATED [] is_a: PHIPO:0000446 ! host cell death phenotype created_by: alaynecuzick creation_date: 2020-06-09T11:25:32Z [Term] id: PHIPO:0001182 name: normal level of deoxynivalenol namespace: single_species_phenotype def: "A single species cell phenotype in which the amount of deoxynivalenol measured in a cell is normal (i.e. indistinguishable from wild type)." [] synonym: "normal level of DON" EXACT [] synonym: "normal level of vomitoxin" EXACT [] is_a: PHIPO:0001039 ! normal cellular toxin level created_by: alaynecuzick creation_date: 2020-06-10T15:09:01Z [Term] id: PHIPO:0001183 name: obsolete host resistance to pathogen phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype that is relevant to host resistance to a given pathogen." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-22T15:25:30Z [Term] id: PHIPO:0001184 name: obsolete loss of functional host resistance gene namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a host to be resistant to a pathogen, via the recognition of a pathogen effector by a specific host resistance gene is abolished (resistance was present and is now absent)." [] subset: qc_do_not_annotate synonym: "loss of host resistance" BROAD [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-22T15:26:41Z [Term] id: PHIPO:0001185 name: obsolete gain of functional host resistance gene namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a host, to be resistant to a pathogen, via the recognition of a pathogen effector by a specific host resistance gene is acquired (resistance was absent and is now present)." [] comment: Gain of function may result from engineering of a natural variant or transformation subset: qc_do_not_annotate synonym: "gain of host resistance" BROAD [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-22T15:26:51Z [Term] id: PHIPO:0001186 name: obsolete functional host resistance gene present namespace: pathogen_host_interaction_phenotype def: "A phenotype where ability of a host to be resistant to a pathogen, via the recognition of a pathogen effector by a specific host resistance gene, is present." [] subset: qc_do_not_annotate synonym: "host resistance present" BROAD [] synonym: "host susceptibility absent" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-22T15:27:22Z [Term] id: PHIPO:0001187 name: obsolete functional host resistance gene absent namespace: pathogen_host_interaction_phenotype def: "A phenotype where ability of a host to be resistant to a pathogen, via the recognition of a pathogen effector by a specific host resistance gene, is absent." [] subset: qc_do_not_annotate synonym: "host resistance absent" BROAD [] synonym: "host susceptibility present" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-22T15:27:41Z [Term] id: PHIPO:0001188 name: obsolete gene-for-gene interaction phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the outcome of a gene-for-gene relationship in plant pathogen interactions. The gene-for-gene hypothesis follows that for each gene controlling resistance (R) in the host there is a corresponding gene controlling avirulence (avr) in the pathogen." [] comment: For use in the annotation extension gene-for-gene interaction. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-23T10:48:16Z [Term] id: PHIPO:0001189 name: obsolete compatible interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the gene-for-gene relationship between the pathogen and plant host results in disease susceptibility." [] subset: qc_extension_only is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-23T10:49:18Z [Term] id: PHIPO:0001190 name: obsolete incompatible interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the gene-for-gene relationship between the pathogen and plant host results in disease resistance." [] subset: qc_extension_only is_obsolete: true created_by: alaynecuzick creation_date: 2020-06-23T10:49:48Z [Term] id: PHIPO:0001191 name: presence of melanin accumulation in pathogen asexual spore within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction, in which the accumulation of melanin within a pathogen asexual spore, usually present during infection, is present." [] synonym: "presence of melanin accumulation in pathogen conidia with host" EXACT [] is_a: PHIPO:0001080 ! altered pathogen pigment accumulation within host created_by: alaynecuzick creation_date: 2020-07-20T11:19:37Z [Term] id: PHIPO:0001192 name: decreased level of host defense-induced reactive oxygen species namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host produced reactive oxygen species (ROS), often associated with an oxidative burst response during infection is lower than normal." [] synonym: "decreased level of pathogen induced host reactive oxygen species" EXACT [] synonym: "decreased level of pathogen induced host ROS" EXACT [] synonym: "decreased level of pathogen-induced host reactive oxygen species" EXACT [] synonym: "decreased level of pathogen-induced host ROS" EXACT [] synonym: "decreased pathogen host interaction oxidative burst" EXACT [] synonym: "decreased pathogen host interaction respiratory burst" EXACT [] is_a: PHIPO:0000924 ! host defense-induced oxidative burst level phenotype created_by: alaynecuzick creation_date: 2020-07-31T09:49:14Z [Term] id: PHIPO:0001193 name: increased level of host defense-induced reactive oxygen species namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host produced reactive oxygen species (ROS), often associated with an oxidative burst response during infection is higher than normal." [] synonym: "increased level of pathogen induced host reactive oxygen species" EXACT [] synonym: "increased level of pathogen-induced host reactive oxygen species" EXACT [] synonym: "increased pathogen host interaction oxidative burst" EXACT [] synonym: "increased pathogen host interaction respiratory burst" EXACT [] is_a: PHIPO:0000924 ! host defense-induced oxidative burst level phenotype created_by: alaynecuzick creation_date: 2020-07-31T09:49:30Z [Term] id: PHIPO:0001194 name: inhibition of pathogen chorismate mutase by host absent namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction molecular function phenotype in which host-mediated inhibition of a pathogen chorismate mutase is absent." [] is_a: PHIPO:0000347 ! pathogen host interaction molecular function phenotype created_by: alaynecuzick creation_date: 2020-07-31T15:28:52Z [Term] id: PHIPO:0001195 name: inhibition of pathogen chorismate mutase by host present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction molecular function phenotype in which host-mediated inhibition of a pathogen chorismate mutase is present." [] is_a: PHIPO:0000347 ! pathogen host interaction molecular function phenotype created_by: alaynecuzick creation_date: 2020-07-31T15:29:07Z [Term] id: PHIPO:0001196 name: host defense-induced substance level phenotype namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0001169 alt_id: PHIPO:0001172 def: "A pathogen host interaction phenotype, which affects the level of a host produced substance during infection." [] synonym: "pathogen induced host substance level phenotype" EXACT [] synonym: "pathogen-induced host substance level phenotype" EXACT [] is_a: PHIPO:0000510 ! pathogen host interaction cell phenotype created_by: alaynecuzick creation_date: 2020-08-03T15:04:15Z [Term] id: PHIPO:0001197 name: level of pathogen produced substance within host phenotype namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0001170 alt_id: PHIPO:0001171 def: "A pathogen host interaction phenotype, which affects the level of a pathogen produced substance during host infection." [] is_a: PHIPO:0000510 ! pathogen host interaction cell phenotype created_by: alaynecuzick creation_date: 2020-08-03T15:40:26Z [Term] id: PHIPO:0001198 name: outcome of interaction phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype that affects the disease outcome of a pathogen host interaction." [] comment: For use in the annotation extension outcome of interaction. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2020-09-14T12:39:58Z [Term] id: PHIPO:0001199 name: disease absent namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where disease is absent." [] subset: qc_extension_only is_a: PHIPO:0001198 ! outcome of interaction phenotype created_by: alaynecuzick creation_date: 2020-09-14T12:42:47Z [Term] id: PHIPO:0001200 name: disease present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where disease is present." [] subset: qc_extension_only is_a: PHIPO:0001198 ! outcome of interaction phenotype created_by: alaynecuzick creation_date: 2020-09-14T12:42:57Z [Term] id: PHIPO:0001201 name: obsolete pathogen effector phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype that is relevant to pathogen effectors." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2020-09-28T12:53:46Z [Term] id: PHIPO:0001202 name: obsolete loss of functional pathogen effector namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen effector to produce an infectious disease is abolished." [] subset: qc_do_not_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2020-09-29T08:11:20Z [Term] id: PHIPO:0001203 name: obsolete gain of functional pathogen effector namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen effector to produce an infectious disease is acquired." [] subset: qc_do_not_annotate is_obsolete: true created_by: alaynecuzick creation_date: 2020-09-29T08:11:34Z [Term] id: PHIPO:0001204 name: decreased extent of host-defense induced lesion by host hypersensitive response namespace: pathogen_host_interaction_phenotype def: "A phenotype where the process of host tissue cell death causing a host lesion is induced by the host activating its own hypersensitive response in defense to a lesser extent than normal." [] comment: This term is to be used for host protection against the pathogen. synonym: "decreased extent of effector-mediated host hypersensitive response during biotrophy" RELATED [] is_a: PHIPO:0000192 ! presence of host-defense induced lesion by host hypersensitive response is_a: PHIPO:0000985 ! decreased extent of pathogen-associated host lesions created_by: alaynecuzick creation_date: 2020-10-14T10:36:53Z [Term] id: PHIPO:0001205 name: abnormal filament morphology namespace: single_species_phenotype def: "A single species phenotype where the morphology of a cell is abnormal." [] is_a: PHIPO:0001221 ! abnormal anatomical structure physical quality phenotype created_by: alaynecuzick creation_date: 2020-11-13T10:05:01Z [Term] id: PHIPO:0001206 name: normal filament morphology namespace: single_species_phenotype def: "A single species phenotype where the morphology of a cell is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001376 ! normal anatomical structure physical quality phenotype created_by: alaynecuzick creation_date: 2020-11-13T10:05:12Z [Term] id: PHIPO:0001207 name: normal filament length namespace: single_species_phenotype def: "A single species cell morphology phenotype where the length of hyphal filaments are normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001206 ! normal filament morphology created_by: alaynecuzick creation_date: 2020-11-13T10:05:35Z [Term] id: PHIPO:0001208 name: unicellular colony morphology phenotype namespace: single_species_phenotype def: "A single species population phenotype affecting the morphology of a colony of unicellular individuals." [] comment: Note that colony morphology terms are not used in PHIPO to annotate filamentous-form colonies because these phenotypes can be related to specific growth terms for hyphal colony morphology please search for PHIPO:0001214 (hyphal growth phenotype). For unicellular colony morphology at the usual resolution it is usually not possible to make any statement about an individual. For dimorphic pathogens these terms are suitable for yeast-form colony phenotypes. is_a: PHIPO:0000509 ! population phenotype created_by: alaynecuzick creation_date: 2020-11-16T12:31:56Z [Term] id: PHIPO:0001210 name: normal hyphal growth namespace: single_species_phenotype alt_id: PHIPO:0000278 alt_id: PHIPO:0000960 alt_id: PHIPO:0000963 alt_id: PHIPO:0001066 alt_id: PHIPO:0001211 def: "An individual organism growth phenotype in which the size or extent of directional growth of hyphae is normal." [] comment: Although this phenotype is for an individual it can be inferred from a population in a colony. synonym: "normal colony morphology" BROAD [] synonym: "normal colony morphology" RELATED [] synonym: "normal filament formation" EXACT [] synonym: "normal filament formation" RELATED [] synonym: "normal filament growth" EXACT [] synonym: "normal filamentous formation" EXACT [] synonym: "normal filamentous formation" RELATED [] synonym: "normal hyphae formation" EXACT [] synonym: "normal hyphae formation" RELATED [] synonym: "normal hyphal colony morphology" BROAD [] synonym: "normal hyphal colony morphology" RELATED [] synonym: "normal hyphal colony shape" RELATED [] synonym: "normal population growth during dimorphic hyphal-form" RELATED [] synonym: "normal size of filamentous colony" RELATED [] is_a: PHIPO:0001214 ! hyphal growth phenotype created_by: alaynecuzick creation_date: 2018-10-03T13:40:03Z [Term] id: PHIPO:0001212 name: decreased hyphal growth namespace: single_species_phenotype alt_id: PHIPO:0000181 alt_id: PHIPO:0001056 alt_id: PHIPO:0001146 def: "An individual organism growth phenotype in which the growth of hyphae is decreased." [] comment: Although this phenotype is for an individual it can be inferred from a population in a colony. synonym: "decreased filament growth" EXACT [] synonym: "decreased filamentous growth" RELATED [] synonym: "decreased size of colony" RELATED [] synonym: "decreased size of filamentous colony" RELATED [] synonym: "reduced filament growth" EXACT [] synonym: "reduced hyphal growth" EXACT [] is_a: PHIPO:0001215 ! abnormal hyphal growth created_by: alaynecuzick creation_date: 2020-11-17T10:05:15Z [Term] id: PHIPO:0001213 name: abolished hyphal growth namespace: single_species_phenotype def: "An individual organism growth phenotype in which the growth of hyphae is abolished (it was present and is now absent)." [] comment: Although this phenotype is for an individual it can be inferred from a population in a colony. synonym: "abolished filament growth" EXACT [] is_a: PHIPO:0001212 ! decreased hyphal growth created_by: alaynecuzick creation_date: 2020-11-17T10:05:33Z [Term] id: PHIPO:0001214 name: hyphal growth phenotype namespace: single_species_phenotype alt_id: PHIPO:0000273 alt_id: PHIPO:0001209 def: "A single species growth phenotype which affects or involves normal or abnormal size, extent or rate of directional growth of the hyphae of an individual organism." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "filamentous colony morphology phenotype" RELATED [] synonym: "filamentous colony shape phenotype" RELATED [] synonym: "filamentous growth phenotype" EXACT [] synonym: "hyphal colony size phenotype" RELATED [] is_a: PHIPO:0000402 ! individual organism phenotype created_by: alaynecuzick creation_date: 2018-10-03T13:38:13Z [Term] id: PHIPO:0001215 name: abnormal hyphal growth namespace: single_species_phenotype alt_id: PHIPO:0000037 alt_id: PHIPO:0000957 alt_id: PHIPO:0000958 alt_id: PHIPO:0001054 alt_id: PHIPO:0001087 def: "An individual organism growth phenotype in which the size or extent of directional growth of hyphae is abnormal." [] comment: Although this phenotype is for an individual it can be inferred from a population in a colony. synonym: "abnormal colony morphology" BROAD [] synonym: "abnormal filament formation" RELATED [] synonym: "abnormal hyphal colony morphology" BROAD [] synonym: "abnormal hyphal colony morphology" RELATED [] synonym: "abnormal hyphal formation" RELATED [] synonym: "abnormal shape of hyphal colony" RELATED [] synonym: "abnormal size of filamentous colony" RELATED [] synonym: "abnormal size of hyphal colony" RELATED [] is_a: PHIPO:0001214 ! hyphal growth phenotype created_by: alaynecuzick creation_date: 2019-06-10T09:31:25Z [Term] id: PHIPO:0001216 name: nutrient phenotype namespace: single_species_phenotype def: "A growth phenotype which describes the change or absence of change of individuals or populations (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2020-12-02T13:30:45Z [Term] id: PHIPO:0001217 name: stress phenotype namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity, resistance or absence of change of individuals or populations after exposure to a specific stress." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2020-12-02T14:07:43Z [Term] id: PHIPO:0001218 name: chemical phenotype namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity, resistance or absence of change of individuals or populations after exposure to a specific chemical." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2020-12-02T14:15:52Z [Term] id: PHIPO:0001219 name: normal growth on voriconazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to voriconazole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2020-12-08T15:43:45Z [Term] id: PHIPO:0001220 name: physical quality phenotype namespace: single_species_phenotype def: "A phenotype that affects any physical object quality, such as morphology, number, location, etc., of an individual, tissue, cell, or cellular component." [] is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2020-12-14T11:23:05Z [Term] id: PHIPO:0001221 name: abnormal anatomical structure physical quality phenotype namespace: single_species_phenotype def: "A physical anatomical structure phenotype in which the amount, distribution, morphology, or other physical characteristic of a cell part, cell, or tissue, or individual is abnormal in the vegetative growth phase of the life cycle." [] is_a: PHIPO:0001373 ! anatomical structure physical quality phenotype created_by: alaynecuzick creation_date: 2020-12-14T11:24:41Z [Term] id: PHIPO:0001222 name: cell viability phenotype namespace: single_species_phenotype def: "A single species cell phenotype that consists of the cell's disposition to survive and develop normally." [] xref: FYPO:0000004 is_a: PHIPO:0000034 ! cell phenotype created_by: alaynecuzick creation_date: 2020-12-14T14:02:19Z [Term] id: PHIPO:0001223 name: normal organism morphology namespace: single_species_phenotype def: "A single species phenotype where the morphology of an organism is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001220 ! physical quality phenotype created_by: alaynecuzick creation_date: 2021-01-25T15:24:55Z [Term] id: PHIPO:0001224 name: increased chitin hydrolysis present namespace: single_species_phenotype def: "A single species metabolic cellular process phenotype, in which the occurrence of a pathogen effector preventing the hydrolysis of chitin by chitinases is decreased (chitin hydrolysis is increased)." [] synonym: "decreased PAMP receptor decoy activity" RELATED [] is_a: PHIPO:0001225 ! chitin hydrolysis present created_by: alaynecuzick creation_date: 2021-01-26T14:18:49Z [Term] id: PHIPO:0001225 name: chitin hydrolysis present namespace: single_species_phenotype def: "A single species metabolic cellular process phenotype, in which a pathogen effector does not prevent the hydrolysis of chitin by chitinases." [] synonym: "abolished PAMP receptor decoy activity" RELATED [] synonym: "PAMP receptor decoy activity absent" RELATED [] is_a: PHIPO:0001147 ! cellular metabolic process phenotype created_by: alaynecuzick creation_date: 2021-01-26T14:26:23Z [Term] id: PHIPO:0001226 name: decreased level of host defense-induced reducing sugar in apoplast namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host produced reducing sugars usually present in the apoplast during infection is lower than normal." [] synonym: "decreased level of host reducing sugar in apoplast induced by pathogen" EXACT [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2021-02-09T09:16:39Z [Term] id: PHIPO:0001227 name: increased level of host defense-induced reducing sugar in apoplast namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host produced reducing sugars usually present in the apoplast during infection is higher than normal." [] synonym: "increased level of host reducing sugar in apoplast induced by pathogen" EXACT [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2021-02-09T09:16:56Z [Term] id: PHIPO:0001228 name: pathogen reactive oxygen species production within host present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen produced reactive oxygen species (ROS) usually present during infection is present as normal (i.e. indistinguishable from wild type)." [] synonym: "pathogen ROS production within host present" EXACT [] is_a: PHIPO:0001197 ! level of pathogen produced substance within host phenotype created_by: alaynecuzick creation_date: 2021-02-09T09:27:11Z [Term] id: PHIPO:0001229 name: presence of pathogen tissue to tissue migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the ability of the pathogen to move directionally from tissue to tissue within the host organism is present." [] is_a: PHIPO:0001159 ! pathogen tissue to tissue migration within host phenotype created_by: alaynecuzick creation_date: 2021-02-11T14:35:06Z [Term] id: PHIPO:0001230 name: host defense-induced phenolic compound present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host phenolic compounds usually present during infection are normal (i.e. indistinguishable from wild type)." [] synonym: "pathogen-induced host phenolic compound present" EXACT [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2021-02-11T14:46:42Z [Term] id: PHIPO:0001231 name: host defense-induced RNA present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host RNA usually present during infection is normal (i.e. indistinguishable from wild type)." [] synonym: "host RNA involved in a pathogen interaction present" EXACT [] is_a: PHIPO:0001263 ! host defense-induced RNA level phenotype created_by: alaynecuzick creation_date: 2021-03-02T14:55:22Z [Term] id: PHIPO:0001232 name: pathogen RNA within host present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of pathogen RNA usually present during host infection is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001267 ! level of pathogen produced RNA within host phenotype created_by: alaynecuzick creation_date: 2021-03-08T09:26:06Z [Term] id: PHIPO:0001233 name: pathogen inhibition of host defense induced acidification in phagolysome namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host induced pH decrease within the host phagolysome in response to pathogen colonization is inhibited." [] is_a: PHIPO:0001108 ! pathogen host interaction pH phenotype created_by: alaynecuzick creation_date: 2021-03-08T13:21:14Z [Term] id: PHIPO:0001234 name: increased hyphal growth namespace: single_species_phenotype def: "An individual organism growth phenotype in which the growth of hyphae is increased." [] comment: Although this phenotype is for an individual it can be inferred from a population in a colony. synonym: "increased filament growth" EXACT [] synonym: "increased filamentous growth" RELATED [] synonym: "increased hyphal growth" EXACT [] synonym: "increased size of colony" RELATED [] synonym: "increased size of filamentous colony" RELATED [] is_a: PHIPO:0001215 ! abnormal hyphal growth created_by: alaynecuzick creation_date: 2021-03-10T09:49:03Z [Term] id: PHIPO:0001235 name: host defense-related RNA involved in a pathogen interaction present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host defense-related RNA usually present during infection is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001231 ! host defense-induced RNA present created_by: alaynecuzick creation_date: 2021-03-16T16:30:04Z [Term] id: PHIPO:0001236 name: effector-mediated suppression of host effector triggered immunity absent namespace: pathogen_host_interaction_phenotype def: "A phenotype where the process of host tissue cell death causing a host lesion initially induced by the host activating its own hypersensitive response in defense, is subsequently not suppressed by a pathogen effector." [] synonym: "effector-mediated suppression of host ETI absent" EXACT [] is_a: PHIPO:0001176 ! effector-mediated immune suppression phenotype created_by: alaynecuzick creation_date: 2021-03-22T16:02:47Z [Term] id: PHIPO:0001237 name: effector-mediated suppression of host PAMP-triggered immunity absent namespace: pathogen_host_interaction_phenotype alt_id: PHIPO:0001129 def: "A cell signaling pathway phenotype where the molecular pattern-induced host innate immune response signaling pathway is not suppressed by a pathogen. (GO:0052034)" [] synonym: "abolished pathogen suppression of host PAMP-triggered immunity" NARROW [] synonym: "abolished pathogen suppression of host PTI" EXACT [] synonym: "abolished pathogen suppression of host PTI" NARROW [] synonym: "abolished suppression of host MAMP-triggered immunity" EXACT [] synonym: "abolished suppression of host MAMP-triggered immunity" NARROW [] synonym: "abolished suppression of host PAMP-triggered immunity" EXACT [] synonym: "abolished suppression of host PAMP-triggered immunity" NARROW [] synonym: "abolished suppression of host PTI" EXACT [] synonym: "abolished suppression of host PTI" NARROW [] synonym: "effector-mediated suppression of host PTI absent" EXACT [] synonym: "suppression of host MAMP-triggered immunity absent" EXACT [] is_a: PHIPO:0001176 ! effector-mediated immune suppression phenotype created_by: alaynecuzick creation_date: 2019-12-03T11:09:29Z [Term] id: PHIPO:0001238 name: increased chitinase activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the observed rate of chitinase activity is increased." [] is_a: PHIPO:0000437 ! increased catalytic activity created_by: alaynecuzick creation_date: 2021-03-23T10:32:17Z [Term] id: PHIPO:0001239 name: pathogen inhibition of host defense induced alkalization namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host induced pH increase in response to pathogen colonization is inhibited." [] is_a: PHIPO:0001108 ! pathogen host interaction pH phenotype created_by: alaynecuzick creation_date: 2021-03-23T11:00:52Z [Term] id: PHIPO:0001240 name: host defense induced alkalization present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host induces a pH increase in response to pathogen colonization." [] is_a: PHIPO:0001108 ! pathogen host interaction pH phenotype created_by: alaynecuzick creation_date: 2021-03-23T11:03:17Z [Term] id: PHIPO:0001241 name: decreased chitinase activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which the observed rate of chitinase activity is decreased." [] is_a: PHIPO:0000436 ! decreased catalytic activity created_by: alaynecuzick creation_date: 2021-03-23T11:09:16Z [Term] id: PHIPO:0001242 name: pathogen binding of chitin with host present namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of chitin or chitin fragments by the pathogen during host colonization is present." [] is_a: PHIPO:0000164 ! pathogen host interaction binding phenotype created_by: alaynecuzick creation_date: 2021-03-23T11:17:39Z [Term] id: PHIPO:0001243 name: pathogen binding of chitin with host absent namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of chitin or chitin fragments by the pathogen during host colonization is absent." [] is_a: PHIPO:0000164 ! pathogen host interaction binding phenotype created_by: alaynecuzick creation_date: 2021-03-23T11:18:11Z [Term] id: PHIPO:0001244 name: increased number of pathogen asexual sporulation structures within host lesion namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of asexual sporulation structures within a host lesion is greater than normal." [] synonym: "increased number of pycnidia within host" RELATED [] is_a: PHIPO:0000469 ! abnormal pathogen asexual sporulation within host created_by: alaynecuzick creation_date: 2021-04-13T12:41:33Z [Term] id: PHIPO:0001245 name: increased protein phosphorylation involved in host PAMP-triggered immunity (MAPK) signaling activated by pathogen namespace: pathogen_host_interaction_phenotype def: "A host immune system signaling pathway pathogen-host interaction phenotype observed during the activation of host PAMP-triggered immunity in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal." [] is_a: PHIPO:0001140 ! host PAMP-triggered immunity signaling activated by pathogen present is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2021-04-21T11:49:31Z [Term] id: PHIPO:0001246 name: host PAMP-triggered immunity activated by pathogen present namespace: pathogen_host_interaction_phenotype def: "A phenotype where the process of pathogen-associated molecular pattern (PAMPs) or microbe-associated molecular pattern (MAMPs), activate the host PAMP-triggered immunity (PTI) innate immune system to trigger host defense responses such as reactive oxygen species (ROS) and callose deposition is present. (PAMPs and MAMPs are conserved structures among microbial species, eg chitin and lipopolysaccharide (LPS))." [] synonym: "host MAMP-triggered immunity activated by pathogen present" EXACT [] synonym: "host PTI activated by pathogen present" EXACT [] is_a: PHIPO:0001167 ! pathogen modulation of host immune system process phenotype created_by: alaynecuzick creation_date: 2021-04-21T11:59:25Z [Term] id: PHIPO:0001247 name: pathogen modulation of host metabolic process phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which a pathogen effects a change in the metabolic processes of its host organism." [] is_a: PHIPO:0001173 ! pathogen modulation of host process phenotype created_by: alaynecuzick creation_date: 2021-04-28T11:22:11Z [Term] id: PHIPO:0001248 name: pathogen modulation of chitin hydrolysis by host present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which a pathogen effector preventing the hydrolysis of chitin by host chitinases is present." [] synonym: "PAMP receptor decoy activity present" RELATED [] is_a: PHIPO:0001128 ! effector-mediated suppression of host PAMP-triggered immunity present is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2021-04-28T11:28:06Z [Term] id: PHIPO:0001249 name: chitin hydrolysis absent namespace: single_species_phenotype def: "A single species metabolic cellular process phenotype, in which a pathogen effector prevents the hydrolysis of chitin by chitinases." [] synonym: "PAMP receptor decoy activity present" RELATED [] is_a: PHIPO:0001147 ! cellular metabolic process phenotype created_by: alaynecuzick creation_date: 2021-04-30T10:10:15Z [Term] id: PHIPO:0001250 name: abnormal host structure induced by pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the development of a host structure is abnormal during pathogen infection." [] is_a: PHIPO:0000001 ! pathogen host interaction phenotype created_by: alaynecuzick creation_date: 2021-08-16T12:59:12Z [Term] id: PHIPO:0001251 name: host defense-induced protein present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host protein usually present during infection is normal (i.e. indistinguishable from wild type)." [] synonym: "host protein involved in a pathogen interaction present" EXACT [] is_a: PHIPO:0001262 ! host defense-induced protein level phenotype created_by: alaynecuzick creation_date: 2022-06-15T11:06:24Z [Term] id: PHIPO:0001252 name: decreased pathogen tissue to tissue migration within host namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction colonization phenotype in which the ability of the pathogen to move directionally from tissue to tissue within the host organism is decreased." [] is_a: PHIPO:0001159 ! pathogen tissue to tissue migration within host phenotype created_by: alaynecuzick creation_date: 2022-06-15T11:13:29Z [Term] id: PHIPO:0001253 name: host immune system inflammatory response activated by pathogen present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host immune system inflammatory response during pathogen infection is present. (GO:0006954 inflammatory response)." [] synonym: "inflammation present" EXACT [] is_a: PHIPO:0001167 ! pathogen modulation of host immune system process phenotype created_by: alaynecuzick creation_date: 2022-06-17T11:09:50Z [Term] id: PHIPO:0001254 name: decreased host immune inflammatory response with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host immune system inflammatory response during pathogen infection occurs to a lesser extent than normal. (GO:0006954 inflammatory response)." [] synonym: "decreased inflammation" EXACT [] is_a: PHIPO:0001253 ! host immune system inflammatory response activated by pathogen present created_by: alaynecuzick creation_date: 2022-06-17T11:49:45Z [Term] id: PHIPO:0001255 name: increased host immune inflammatory response with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host immune system inflammatory response during pathogen infection occurs to a greater extent than normal. (GO:0006954 inflammatory response)." [] synonym: "increased inflammation" EXACT [] is_a: PHIPO:0001253 ! host immune system inflammatory response activated by pathogen present created_by: alaynecuzick creation_date: 2022-06-20T09:58:39Z [Term] id: PHIPO:0001256 name: host defense-related protein involved in a pathogen interaction present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the host defense-related protein usually present during infection is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001251 ! host defense-induced protein present created_by: alaynecuzick creation_date: 2022-06-20T10:03:29Z [Term] id: PHIPO:0001257 name: decreased level of host defense-induced protein namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host protein usually present during infection is lower than normal." [] is_a: PHIPO:0001262 ! host defense-induced protein level phenotype created_by: alaynecuzick creation_date: 2022-06-20T10:21:16Z [Term] id: PHIPO:0001258 name: decreased expression of a host defense-related protein involved in a pathogen interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host defense-related protein usually present during infection is lower than normal." [] is_a: PHIPO:0001257 ! decreased level of host defense-induced protein created_by: alaynecuzick creation_date: 2022-06-20T10:23:47Z [Term] id: PHIPO:0001259 name: host cell viability with pathogen phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction cell level phenotype which affects the viability of a host cell in the presence of a pathogen." [] synonym: "cytotoxicity phenotype" BROAD [] is_a: PHIPO:0000510 ! pathogen host interaction cell phenotype created_by: alaynecuzick creation_date: 2022-07-01T09:19:41Z [Term] id: PHIPO:0001260 name: host cell viable with pathogen namespace: pathogen_host_interaction_phenotype def: "A host cell viability phenotype where the host cell survives in the presence of the pathogen." [] is_a: PHIPO:0001259 ! host cell viability with pathogen phenotype created_by: alaynecuzick creation_date: 2022-07-01T09:24:19Z [Term] id: PHIPO:0001261 name: host cell inviable with pathogen namespace: pathogen_host_interaction_phenotype def: "A host cell viability phenotype where the host cell death is accelerated by the pathogen." [] is_a: PHIPO:0001259 ! host cell viability with pathogen phenotype created_by: alaynecuzick creation_date: 2022-07-01T09:27:27Z [Term] id: PHIPO:0001262 name: host defense-induced protein level phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, which affects the level of a host produced protein during infection." [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2022-07-01T09:51:01Z [Term] id: PHIPO:0001263 name: host defense-induced RNA level phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, which affects the level of a host produced RNA during infection." [] is_a: PHIPO:0001196 ! host defense-induced substance level phenotype created_by: alaynecuzick creation_date: 2022-07-01T09:59:49Z [Term] id: PHIPO:0001264 name: host physiological process affected by pathogen phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which a pathogen effects a change in the physiological processes of its host organism." [] is_a: PHIPO:0001173 ! pathogen modulation of host process phenotype created_by: alaynecuzick creation_date: 2022-07-04T08:38:22Z [Term] id: PHIPO:0001265 name: host hemorrhage with pathogen present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which host bleeding occurs during pathogen infection (MP:0001914 hemorrhage)." [] synonym: "host bleeding with pathogen present" EXACT [] synonym: "host haemorrhage with pathogen present" EXACT [] is_a: PHIPO:0001264 ! host physiological process affected by pathogen phenotype created_by: alaynecuzick creation_date: 2022-07-04T08:41:51Z [Term] id: PHIPO:0001266 name: increased host hemorrhage with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the host bleeding during pathogen infection occurs to a greater extent than normal (MP:0001914 hemorrhage)." [] synonym: "increased host bleeding with pathogen" EXACT [] synonym: "increased host haemorrhage with pathogen" EXACT [] is_a: PHIPO:0001265 ! host hemorrhage with pathogen present created_by: alaynecuzick creation_date: 2022-07-04T08:45:10Z [Term] id: PHIPO:0001267 name: level of pathogen produced RNA within host phenotype namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, which affects the level of pathogen produced RNA during host infection." [] is_a: PHIPO:0001197 ! level of pathogen produced substance within host phenotype created_by: alaynecuzick creation_date: 2022-07-04T08:58:03Z [Term] id: PHIPO:0001268 name: presence of host gall during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the presence of a pathogen (or symbiont) has resulted in the abnormal growth of the host tissue, forming a plant gall (BTO:0005833 plant gall)." [] is_a: PHIPO:0001006 ! abnormal host morphology during pathogen invasion created_by: alaynecuzick creation_date: 2022-07-05T12:52:20Z [Term] id: PHIPO:0001269 name: decreased number of host galls during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the presence of a pathogen (or symbiont) has resulted in a decreased number of plant galls (BTO:0005833 plant gall)." [] is_a: PHIPO:0001268 ! presence of host gall during pathogen invasion created_by: alaynecuzick creation_date: 2022-07-05T12:57:02Z [Term] id: PHIPO:0001270 name: sensitive to calcium ion starvation namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to calcium ion starvation. Typically, individuals or populations are deemed sensitive to a stress if they stop growing (and may die) when exposed to the stress at an intensity that allows an individual or population of wild type cell(s) to grow and divide." [] synonym: "hypersensitive to calcium ion starvation" EXACT [] synonym: "reduced growth in low calcium" EXACT [] synonym: "sensitive to calcium ion depletion" EXACT [] synonym: "sensitive to calcium ion deprivation" EXACT [] synonym: "sensitive to calcium starvation" EXACT [] xref: FYPO:0001201 is_a: PHIPO:0001098 ! sensitive to stress created_by: alaynecuzick creation_date: 2022-07-27T11:20:23Z [Term] id: PHIPO:0001271 name: presence of pathogen sexual spores within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the frequency of occurrence of sexual spores is normal (i.e. indistinguishable from wild type)." [] synonym: "presence of pathogen teliospores within host" BROAD [] is_a: PHIPO:0000443 ! normal pathogen sexual reproduction within host created_by: alaynecuzick creation_date: 2022-08-15T16:22:41Z [Term] id: PHIPO:0001272 name: stunted growth namespace: single_species_phenotype def: "A single species growth phenotype where there is a decrease in size of an entire multicellular organism." [] is_a: PHIPO:0000402 ! individual organism phenotype created_by: alaynecuzick creation_date: 2022-08-25T08:11:36Z [Term] id: PHIPO:0001273 name: abnormal host morphology during phagocytosis of pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the morphology of the host cell is irregular due to the phagocytosis (engulfment and ingestion) of the pathogen (GO:0006911)." [] synonym: "irregular host morphology during phagocytosis of pathogen" EXACT [] is_a: PHIPO:0001006 ! abnormal host morphology during pathogen invasion created_by: alaynecuzick creation_date: 2022-08-25T09:26:08Z [Term] id: PHIPO:0001274 name: host immune system phagocytosis of pathogen present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the host immune system activates the phagocytosis of a pathogen (GO:0006911)." [] is_a: PHIPO:0001167 ! pathogen modulation of host immune system process phenotype created_by: alaynecuzick creation_date: 2022-08-25T10:07:49Z [Term] id: PHIPO:0001275 name: presence of viable pathogen sexual spores within host namespace: pathogen_host_interaction_phenotype def: "A pathogen reproductive phenotype within host in which the viability of sexual spores is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001271 ! presence of pathogen sexual spores within host created_by: alaynecuzick creation_date: 2022-09-09T13:22:21Z [Term] id: PHIPO:0001276 name: increased number of host galls during pathogen invasion namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype where the presence of a pathogen (or symbiont) has resulted in an increased number of plant galls (BTO:0005833 plant gall)." [] is_a: PHIPO:0001268 ! presence of host gall during pathogen invasion created_by: alaynecuzick creation_date: 2022-09-09T13:28:14Z [Term] id: PHIPO:0001277 name: presence of pathogen induced host DNA synthesis namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which host DNA synthesis occurs during pathogen infection (GO:0090592 DNA synthesis involved in DNA replication)." [] is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2022-09-09T14:04:31Z [Term] id: PHIPO:0001278 name: decreased pathogen induced host DNA synthesis namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the host DNA synthesis during pathogen infection occurs to a lesser extent than normal (GO:0090592 DNA synthesis involved in DNA replication)." [] is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2022-09-09T14:06:29Z [Term] id: PHIPO:0001279 name: abolished peptidase activity namespace: single_species_phenotype def: "A single species molecular function phenotype in which a peptidase activity is absent." [] synonym: "abolished protease activity" EXACT [] synonym: "peptidase activity abolished" EXACT [] xref: FYPO:0000669 is_a: PHIPO:0000435 ! abolished catalytic activity created_by: alaynecuzick creation_date: 2022-11-07T10:37:31Z [Term] id: PHIPO:0001280 name: increased pathogen induced host DNA synthesis namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the host DNA synthesis during pathogen infection occurs to a greater extent than normal (GO:0090592 DNA synthesis involved in DNA replication)." [] is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2022-11-07T14:30:40Z [Term] id: PHIPO:0001281 name: presence of host protein phosphorylation with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the phosphorylation of one or more specific host proteins, or of specific host protein sites, occurs during pathogen infection (GO:0006468 protein phosphorylation)." [] is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2022-11-11T13:05:20Z [Term] id: PHIPO:0001282 name: absence of host protein phosphorylation with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the phosphorylation of one or more specific host proteins, or of specific host protein sites, does not occur during pathogen infection (GO:0006468 protein phosphorylation)." [] is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2022-11-11T13:06:37Z [Term] id: PHIPO:0001283 name: increased host protein phosphorylation with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the phosphorylation of one or more specific host proteins, or of specific host protein sites, during pathogen infection occurs to a greater extent than normal (GO:0006468 protein phosphorylation)." [] is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2022-11-11T13:10:07Z [Term] id: PHIPO:0001284 name: decreased host protein phosphorylation with pathogen namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype in which the phosphorylation of one or more specific host proteins, or of specific host protein sites, during pathogen infection occurs to a lesser extent than normal (GO:0006468 protein phosphorylation)." [] is_a: PHIPO:0001247 ! pathogen modulation of host metabolic process phenotype created_by: alaynecuzick creation_date: 2022-11-11T13:11:15Z [Term] id: PHIPO:0001285 name: increased level of host defense-related RNA involved in a pathogen interaction namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction phenotype, in which the level of host defense-related RNA usually present during infection is higher than normal." [] synonym: "increased level of host defense related RNA involved in a pathogen interaction" EXACT [] is_a: PHIPO:0001104 ! increased level of host defense-induced RNA created_by: alaynecuzick creation_date: 2022-11-22T10:38:36Z [Term] id: PHIPO:0001286 name: presence of pathogen protein host DNA interaction namespace: pathogen_host_interaction_phenotype def: "A molecular function phenotype in which the binding of one pathogen protein to host DNA is present." [] synonym: "presence of pathogen protein host DNA binding" EXACT [] is_a: PHIPO:0000164 ! pathogen host interaction binding phenotype created_by: alaynecuzick creation_date: 2022-11-22T10:43:32Z [Term] id: PHIPO:0001287 name: normal growth on tolnaftate namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to tolnaftate (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-06-12T08:49:10Z [Term] id: PHIPO:0001288 name: resistance to tolnaftate namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tolnaftate. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-06-12T09:02:28Z [Term] id: PHIPO:0001289 name: sensitive to tolnaftate namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tolnaftate. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-06-12T09:05:32Z [Term] id: PHIPO:0001290 name: normal growth on azoxystrobin namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to azoxystrobin (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-06-12T09:21:50Z [Term] id: PHIPO:0001291 name: resistance to fenpicoxamid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fenpicoxamid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-06-12T09:34:07Z [Term] id: PHIPO:0001292 name: sensitive to fenpicoxamid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fenpicoxamid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-06-12T09:37:49Z [Term] id: PHIPO:0001293 name: normal growth on fenpicoxamid namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to fenpicoxamid (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-06-12T09:41:30Z [Term] id: PHIPO:0001294 name: inhibition of pathogen polygalacturonase by host present namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction molecular function phenotype in which host-mediated inhibition of a pathogen polygalacturonase is present." [] is_a: PHIPO:0000347 ! pathogen host interaction molecular function phenotype created_by: alaynecuzick creation_date: 2023-06-16T11:19:19Z [Term] id: PHIPO:0001295 name: inhibition of pathogen polygalacturonase by host decreased namespace: pathogen_host_interaction_phenotype def: "A pathogen host interaction molecular function phenotype in which host-mediated inhibition of a pathogen polygalacturonase\noccurs to a lesser extent than normal." [] is_a: PHIPO:0000347 ! pathogen host interaction molecular function phenotype created_by: alaynecuzick creation_date: 2023-06-16T11:21:35Z [Term] id: PHIPO:0001296 name: resistance to arborcandin C namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to arborcandin C. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-06-21T11:31:01Z [Term] id: PHIPO:0001297 name: sensitive to arborcandin C namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to arborcandin C. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-06-21T11:33:40Z [Term] id: PHIPO:0001298 name: normal growth on arborcandin C namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to arborcandin C (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-06-21T11:35:28Z [Term] id: PHIPO:0001299 name: normal growth on pyrrolnitrin namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to pyrrolnitrin (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-06-27T13:33:13Z [Term] id: PHIPO:0001300 name: sensitive to pyrrolnitrin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to pyrrolnitrin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-06-27T13:35:46Z [Term] id: PHIPO:0001301 name: resistance to pyrrolnitrin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to pyrrolnitrin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-06-27T13:37:29Z [Term] id: PHIPO:0001302 name: resistance to osmotic stress namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to an osmotic stress. Typically, individuals or populations are deemed resistant to a stress if they grow when exposed to the stress at an intensity at which an individual or population of wild type cell(s) stop growing (and may die)." [] synonym: "resistant to osmotic stress" EXACT [] xref: FYPO:0000851 is_a: PHIPO:0001096 ! resistance to stress created_by: alaynecuzick creation_date: 2023-06-27T14:23:57Z [Term] id: PHIPO:0001303 name: sensitive to osmotic stress namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to an osmotic stress. Typically, individuals or populations are deemed sensitive to a stress if they stop growing (and may die) when exposed to the stress at an intensity that allows an individual or population of wild type cell(s) to grow and divide." [] xref: FYPO:0000270 is_a: PHIPO:0001098 ! sensitive to stress created_by: alaynecuzick creation_date: 2023-06-27T14:27:20Z [Term] id: PHIPO:0001304 name: resistance to salt stress namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to a salt stress. Typically, individuals or populations are deemed resistant to a stress if they grow when exposed to the stress at an intensity at which an individual or population of wild type cell(s) stop growing (and may die)." [] synonym: "ionic stress resistance: increased" EXACT [] synonym: "resistant to salt stress" EXACT [] xref: FYPO:0000852 is_a: PHIPO:0001302 ! resistance to osmotic stress created_by: alaynecuzick creation_date: 2023-06-30T12:46:55Z [Term] id: PHIPO:0001305 name: resistance to non-ionic osmotic stress namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to a non-ionic osmotic stress. Typically, individuals or populations are deemed sensitive to a stress if they stop growing (and may die) when exposed to the stress at an intensity that allows an individual or population of wild type cell(s) to grow and divide." [] synonym: "resistant to non-ionic osmotic stress" EXACT [] is_a: PHIPO:0001302 ! resistance to osmotic stress created_by: alaynecuzick creation_date: 2023-06-30T12:55:08Z [Term] id: PHIPO:0001306 name: sensitive to salt stress namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to a salt stress. Typically, individuals or populations are deemed sensitive to a stress if they stop growing (and may die) when exposed to the stress at an intensity that allows an individual or population of wild type cell(s) to grow and divide." [] synonym: "hypersensitive to salt stress" EXACT [] synonym: "ionic stress resistance: decreased" EXACT [] xref: FYPO:0000271 is_a: PHIPO:0001303 ! sensitive to osmotic stress created_by: alaynecuzick creation_date: 2023-06-30T12:57:45Z [Term] id: PHIPO:0001307 name: sensitive to non-ionic osmotic stress namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to a non-ionic osmotic stress. Typically, individuals or populations are deemed sensitive to a stress if they stop growing (and may die) when exposed to the stress at an intensity that allows an individual or population of wild type cell(s) to grow and divide." [] synonym: "hypersensitive to non-ionic osmotic stress" EXACT [] xref: FYPO:0002811 is_a: PHIPO:0001303 ! sensitive to osmotic stress created_by: alaynecuzick creation_date: 2023-06-30T13:00:44Z [Term] id: PHIPO:0001308 name: normal growth on chemical namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to a specific chemical (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001218 ! chemical phenotype created_by: alaynecuzick creation_date: 2023-07-21T15:06:54Z [Term] id: PHIPO:0001309 name: normal growth on benomyl namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to benomyl (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-07-21T15:13:15Z [Term] id: PHIPO:0001310 name: normal growth on carbendazim namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to carbendazim (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-07-21T15:16:51Z [Term] id: PHIPO:0001311 name: normal growth on chlorothalonil namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to chlorothalonil (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-02T16:52:35Z [Term] id: PHIPO:0001312 name: normal growth on zoxamide namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to zoxamide (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-02T16:56:31Z [Term] id: PHIPO:0001313 name: resistance to zoxamide namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to zoxamide. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:00:21Z [Term] id: PHIPO:0001314 name: sensitive to zoxamide namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to zoxamide. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:03:39Z [Term] id: PHIPO:0001315 name: normal growth on cymoxanil namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to cymoxanil (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-02T17:08:04Z [Term] id: PHIPO:0001316 name: resistance to cymoxanil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to cymoxanil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:10:17Z [Term] id: PHIPO:0001317 name: sensitive to cymoxanil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to cymoxanil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:12:34Z [Term] id: PHIPO:0001318 name: normal growth on metalaxyl namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to metalaxyl (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-02T17:43:33Z [Term] id: PHIPO:0001319 name: resistance to metalaxyl namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to metalaxyl. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:45:42Z [Term] id: PHIPO:0001320 name: sensitive to metalaxyl namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to metalaxyl. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:47:59Z [Term] id: PHIPO:0001321 name: normal growth on flumorph namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to flumorph (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-02T17:50:56Z [Term] id: PHIPO:0001322 name: resistance to flumorph namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to flumorph. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:53:00Z [Term] id: PHIPO:0001323 name: sensitive to flumorph namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to flumorph. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-02T17:55:02Z [Term] id: PHIPO:0001324 name: normal growth on pyrimethanil namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to pyrimethanil (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:09:48Z [Term] id: PHIPO:0001325 name: normal growth on tebuconazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to tebuconazole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:15:40Z [Term] id: PHIPO:0001326 name: normal growth on prochloraz namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to prochloraz (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:18:09Z [Term] id: PHIPO:0001327 name: normal growth on iprodione namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to iprodione (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:20:20Z [Term] id: PHIPO:0001328 name: normal growth on myclobutanil namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to myclobutanil (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:22:50Z [Term] id: PHIPO:0001329 name: normal growth on fluazinam namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to fluazinam (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:25:21Z [Term] id: PHIPO:0001330 name: normal growth on thiram namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to thiram (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:27:38Z [Term] id: PHIPO:0001331 name: normal growth on procymidone namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to procymidone (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T12:29:52Z [Term] id: PHIPO:0001332 name: resistance to procymidone namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to procymidone. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:32:57Z [Term] id: PHIPO:0001333 name: resistance to thiram namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to thiram. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:35:23Z [Term] id: PHIPO:0001334 name: resistance to fluazinam namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fluazinam. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:37:30Z [Term] id: PHIPO:0001335 name: resistance to myclobutanil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to myclobutanil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:39:12Z [Term] id: PHIPO:0001336 name: sensitive to myclobutanil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to myclobutanil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:45:23Z [Term] id: PHIPO:0001337 name: sensitive to fluazinam namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fluazinam. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:47:42Z [Term] id: PHIPO:0001338 name: sensitive to thiram namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to thiram. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:50:06Z [Term] id: PHIPO:0001339 name: sensitive to procymidone namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to procymidone. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-05T12:52:11Z [Term] id: PHIPO:0001340 name: resistance to nocodazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to nocodazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-05T14:36:00Z [Term] id: PHIPO:0001341 name: normal growth on thiabendazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to thiabendazole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-05T14:38:27Z [Term] id: PHIPO:0001342 name: resistance to triflumizole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to triflumizole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001343 name: sensitive to triflumizole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to triflumizole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001344 name: normal growth on triflumizole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to triflumizole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001345 name: resistance to bitertanol namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to bitertanol. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001346 name: sensitive to bitertanol namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to bitertanol. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001347 name: normal growth on bitertanol namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to bitertanol (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001348 name: resistance to pyrifenox namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to pyrifenox. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001349 name: sensitive to pyrifenox namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to pyrifenox. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001350 name: normal growth on pyrifenox namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to pyrifenox (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-08-10T12:06:26Z [Term] id: PHIPO:0001351 name: normal growth on itraconazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to itraconazole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-09-06T13:58:46Z [Term] id: PHIPO:0001352 name: normal growth on amphotericin B namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to amphotericin B (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-09-06T14:01:34Z [Term] id: PHIPO:0001353 name: resistance to prothioconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to prothioconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-09-11T11:50:04Z [Term] id: PHIPO:0001354 name: sensitive to prothioconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to prothioconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-09-11T11:50:04Z [Term] id: PHIPO:0001355 name: normal growth on prothioconazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to prothioconazole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-09-11T11:50:04Z [Term] id: PHIPO:0001356 name: resistance to fluopyram namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fluopyram. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-09-27T09:40:25Z [Term] id: PHIPO:0001357 name: sensitive to fluopyram namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fluopyram. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-09-27T09:40:25Z [Term] id: PHIPO:0001358 name: normal growth on fluopyram namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to fluopyram (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-09-27T09:40:25Z [Term] id: PHIPO:0001359 name: resistance to kresoxim-methyl namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to kresoxim-methyl. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-09-28T11:07:02Z [Term] id: PHIPO:0001360 name: sensitive to kresoxim-methyl namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to kresoxim-methyl. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-09-28T11:07:02Z [Term] id: PHIPO:0001361 name: normal growth on kresoxim-methyl namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to kresoxim-methyl (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-09-28T11:07:02Z [Term] id: PHIPO:0001362 name: resistance to isopyrazam namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to isopyrazam. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-10-02T14:15:15Z [Term] id: PHIPO:0001363 name: sensitive to isopyrazam namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to isopyrazam. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-10-02T14:15:15Z [Term] id: PHIPO:0001364 name: normal growth on isopyrazam namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to isopyrazam (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-10-02T14:15:15Z [Term] id: PHIPO:0001365 name: resistance to bixafen namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to bixafen. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-10-02T14:15:15Z [Term] id: PHIPO:0001366 name: sensitive to bixafen namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to bixafen. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-10-02T14:15:15Z [Term] id: PHIPO:0001367 name: normal growth on bixafen namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to bixafen (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-10-02T14:15:15Z [Term] id: PHIPO:0001368 name: normal growth on carboxin namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to carboxin (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-10-02T14:15:15Z [Term] id: PHIPO:0001369 name: increased rate of hyphae formation namespace: single_species_phenotype def: "An individual organism growth phenotype in which the rate, or speed, of hyphae formation is increased." [] synonym: "fast hyphae formation" EXACT [] is_a: PHIPO:0001234 ! increased hyphal growth created_by: alaynecuzick creation_date: 2023-10-09T12:23:25Z [Term] id: PHIPO:0001370 name: resistance to pyrimorph namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to pyrimorph. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-10-10T15:36:59Z [Term] id: PHIPO:0001371 name: sensitive to pyrimorph namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to pyrimorph. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-10-10T15:36:59Z [Term] id: PHIPO:0001372 name: normal growth on pyrimorph namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to pyrimorph (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-10-10T15:36:59Z [Term] id: PHIPO:0001373 name: anatomical structure physical quality phenotype namespace: single_species_phenotype def: "A phenotype that affects any anatomical structure physical quality, such as morphology, number, location, etc." [] is_a: PHIPO:0001220 ! physical quality phenotype created_by: alaynecuzick creation_date: 2023-10-17T11:46:05Z [Term] id: PHIPO:0001374 name: increased number of resting structures namespace: single_species_phenotype def: "A single species phenotype where the frequency of occurrence of resting structures is increased." [] synonym: "increased number of sclerotia" RELATED [] is_a: PHIPO:0001221 ! abnormal anatomical structure physical quality phenotype created_by: alaynecuzick creation_date: 2023-10-17T12:48:52Z [Term] id: PHIPO:0001375 name: decreased number of resting structures namespace: single_species_phenotype def: "A single species phenotype where the frequency of occurrence of resting structures is decreased." [] synonym: "decreased number of sclerotia" RELATED [] is_a: PHIPO:0001221 ! abnormal anatomical structure physical quality phenotype created_by: alaynecuzick creation_date: 2023-10-17T12:52:42Z [Term] id: PHIPO:0001376 name: normal anatomical structure physical quality phenotype namespace: single_species_phenotype def: "A physical anatomical structure phenotype in which the amount, distribution, morphology, or other physical characteristic of a cell part, cell, or tissue, or individual is normal in the vegetative growth phase of the life cycle (i.e. indistinguishable from wild type.)" [] is_a: PHIPO:0001373 ! anatomical structure physical quality phenotype created_by: alaynecuzick creation_date: 2023-10-17T13:00:17Z [Term] id: PHIPO:0001377 name: normal number of resting structures namespace: single_species_phenotype def: "A single species phenotype where the number of resting structures is normal (i.e. indistinguishable from wild type)." [] synonym: "normal number of sclerotia" RELATED [] is_a: PHIPO:0001376 ! normal anatomical structure physical quality phenotype created_by: alaynecuzick creation_date: 2023-10-17T13:03:53Z [Term] id: PHIPO:0001378 name: resistance to tacrolimus namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to tacrolimus. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-10-17T14:21:39Z [Term] id: PHIPO:0001379 name: sensitive to tacrolimus namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to tacrolimus. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-10-17T14:21:39Z [Term] id: PHIPO:0001380 name: normal growth on tacrolimus namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to tacrolimus (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-10-17T14:21:39Z [Term] id: PHIPO:0001381 name: sensitive to iron namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to iron. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] synonym: "hypersensitive to iron" EXACT [] synonym: "sensitive to iron ions" EXACT [] xref: FYPO:0005825 is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-11-13T15:10:47Z [Term] id: PHIPO:0001382 name: resistance to fenpiclonil namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to fenpiclonil. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-11-21T10:43:41Z [Term] id: PHIPO:0001383 name: sensitive to fenpiclonil namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to fenpiclonil. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-11-21T10:43:41Z [Term] id: PHIPO:0001384 name: normal growth on fenpiclonil namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to fenpiclonil (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-11-21T10:43:41Z [Term] id: PHIPO:0001385 name: resistance to phenamacril namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to phenamacril. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-11-21T12:08:01Z [Term] id: PHIPO:0001386 name: sensitive to phenamacril namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to phenamacril. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-11-21T12:08:01Z [Term] id: PHIPO:0001387 name: normal growth on phenamacril namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to phenamacril (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-11-21T12:08:01Z [Term] id: PHIPO:0001388 name: resistance to pyrisoxazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to pyrisoxazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] synonym: "resistance to SYP-Z048" EXACT [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2023-12-04T14:19:53Z [Term] id: PHIPO:0001389 name: sensitive to pyrisoxazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to pyrisoxazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] synonym: "sensitive to SYP-Z048" EXACT [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2023-12-04T14:19:53Z [Term] id: PHIPO:0001390 name: normal growth on pyrisoxazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to pyrisoxazole (i.e. indistinguishable from wild type)." [] synonym: "normal growth on SYP-Z048" EXACT [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2023-12-04T14:19:53Z [Term] id: PHIPO:0001391 name: resistance to metconazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to metconazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2024-01-10T15:25:16Z [Term] id: PHIPO:0001392 name: sensitive to metconazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to metconazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2024-01-10T15:25:16Z [Term] id: PHIPO:0001393 name: normal growth on metconazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to metconazole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2024-01-10T15:25:16Z [Term] id: PHIPO:0001394 name: resistance to trifloxystrobin namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to trifloxystrobin. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2024-01-22T12:34:13Z [Term] id: PHIPO:0001395 name: sensitive to trifloxystrobin namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to trifloxystrobin. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2024-01-22T12:34:13Z [Term] id: PHIPO:0001396 name: normal growth on trifloxystrobin namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to trifloxystrobin (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2024-01-22T12:34:13Z [Term] id: PHIPO:0001397 name: sensitive to cell wall stress namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to a cell wall stress. Typically, individuals or populations are deemed sensitive to a stress if they grow when exposed to the stress at an intensity at which an individual or population of wild type cell(s) stop growing (and may die)." [] is_a: PHIPO:0001098 ! sensitive to stress created_by: alaynecuzick creation_date: 2024-01-23T11:47:46Z [Term] id: PHIPO:0001398 name: sensitive to oxidative stress namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to an oxidative stress. Typically, individuals or populations are deemed sensitive to a stress if they grow when exposed to the stress at an intensity at which an individual or population of wild type cell(s) stop growing (and may die)." [] is_a: PHIPO:0001098 ! sensitive to stress created_by: alaynecuzick creation_date: 2024-01-23T12:01:41Z [Term] id: PHIPO:0001399 name: resistance to flusilazole namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to flusilazole. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001400 name: sensitive to flusilazole namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to flusilazole. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001401 name: normal growth on flusilazole namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to flusilazole (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001402 name: resistance to mandipropamid namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to mandipropamid. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001403 name: sensitive to mandipropamid namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to mandipropamid. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001404 name: normal growth on mandipropamid namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to mandipropamid (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001405 name: resistance to dimethomorph namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to dimethomorph. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001406 name: sensitive to dimethomorph namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to dimethomorph. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001407 name: normal growth on dimethomorph namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to dimethomorph (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001408 name: resistance to iprovalicarb namespace: single_species_phenotype def: "A growth phenotype which describes the resistance of individuals or populations after exposure to iprovalicarb. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] is_a: PHIPO:0000022 ! increased resistance to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001409 name: sensitive to iprovalicarb namespace: single_species_phenotype def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to iprovalicarb. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] is_a: PHIPO:0000021 ! increased sensitivity to chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PHIPO:0001410 name: normal growth on iprovalicarb namespace: single_species_phenotype def: "A growth phenotype which describes the absence of change of individuals or populations after exposure to iprovalicarb (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0001308 ! normal growth on chemical created_by: alaynecuzick creation_date: 2024-01-30T14:16:53Z [Term] id: PR:000000001 name: protein namespace: protein def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." [PRO:DAN, PRO:WCB] comment: The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB]. synonym: "native protein" NARROW [IEDB:BP] synonym: "natural protein" EXACT [PRO:DAN] is_a: CHEBI:36080 ! protein intersection_of: PR:000018263 ! amino acid chain intersection_of: has_gene_template SO:0000704 intersection_of: output_of GO:0006412 ! translation [Term] id: PR:000018263 name: amino acid chain namespace: protein def: "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." [PRO:DAN, PRO:JSG] comment: Category=polymer. synonym: "peptide" NARROW [PRO:DAN] synonym: "polypeptide" NARROW [PRO:DAN] is_a: CHEBI:50047 ! organic amino compound relationship: has_constituent_monomer CHEBI:33708 {minCardinality="2"} ! amino-acid residue [Term] id: PR:000036194 name: eukaryotic protein namespace: protein def: "A protein that is encoded in the genome of some Eukaryota." [PRO:DAN] synonym: "Eukaryota protein" EXACT [PRO:DAN] is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: only_in_taxon NCBITaxon:2759 ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: PR:000050567 name: protein-containing material entity namespace: protein def: "A material entity that minimally consists of a protein." [PRO:DAN] comment: Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050566). synonym: "protein" NARROW [PRO:DAN] synonym: "protein aggregate" NARROW [PRO:DAN] synonym: "protein complex" NARROW [PRO:DAN] synonym: "protein-containing complex" NARROW [PRO:DAN] is_a: BFO:0000040 ! material entity intersection_of: BFO:0000040 ! material entity intersection_of: has_part PR:000000001 ! protein relationship: has_part PR:000000001 ! protein [Term] id: Subset is_a: IAO:0000102 ! data about an ontology part [Term] id: UBERON:0000000 name: processual entity namespace: uberon def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." [span:ProcessualEntity] subset: common_anatomy subset: upper_level disjoint_from: UBERON:0001062 ! anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000061 name: anatomical structure namespace: uberon def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003] subset: common_anatomy subset: upper_level synonym: "biological structure" EXACT [] synonym: "connected biological structure" EXACT [CARO:0000003] xref: AAO:0010825 xref: AEO:0000003 xref: BILA:0000003 xref: CARO:0000003 xref: EHDAA2:0003003 xref: EMAPA:0 xref: FBbt:00007001 xref: FMA:305751 xref: FMA:67135 xref: GAID:781 xref: HAO:0000003 xref: http://dbpedia.org/ontology/AnatomicalStructure xref: MA:0003000 xref: MESH:D000825 xref: SCTID:362889002 xref: TAO:0000037 xref: TGMA:0001823 xref: VHOG:0001759 xref: XAO:0003000 xref: ZFA:0000037 is_a: UBERON:0000465 ! material anatomical entity relationship: existence_ends_during_or_before UBERON:0000071 ! death stage property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000071 name: death stage namespace: uberon def: "End of the life of an organism." [XAO:0000437] subset: common_anatomy synonym: "death" RELATED [] xref: XAO:0000437 xref: XtroDO:0000085 is_a: BFO:0000003 ! occurrent is_a: UBERON:0000105 ! life cycle stage relationship: ends UBERON:0000104 ! life cycle property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: UBPROP:0000012 "ncit:Death is an outcome" xsd:string {external_ontology="ncit"} [Term] id: UBERON:0000104 name: life cycle namespace: uberon def: "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." [https://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: upper_level synonym: "entire life cycle" EXACT [] synonym: "entire lifespan" EXACT [] synonym: "life" EXACT [] synonym: "lifespan" EXACT [] xref: FBdv:00000000 xref: HsapDv:0000001 xref: MmusDv:0000001 xref: ncithesaurus:Life xref: OGES:000011 is_a: BFO:0000003 ! occurrent is_a: UBERON:0000000 ! processual entity relationship: ends_with UBERON:0000071 ! death stage relationship: has_part UBERON:0000105 ! life cycle stage property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: seeAlso "https://github.com/obophenotype/uberon/issues/532" xsd:anyURI [Term] id: UBERON:0000105 name: life cycle stage namespace: uberon def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [https://orcid.org/0000-0002-6601-2165] subset: common_anatomy subset: efo_slim subset: upper_level synonym: "developmental stage" NARROW [] synonym: "stage" NARROW [] xref: BILS:0000105 xref: EFO:0000399 xref: FBdv:00007012 xref: FMA:24120 xref: HsapDv:0000000 xref: MESH:D008018 xref: MmusDv:0000000 xref: ncithesaurus:Developmental_Stage xref: OlatDv:0000010 xref: PdumDv:0000090 xref: WBls:0000002 xref: XAO:1000000 xref: ZFS:0000000 xref: ZFS:0100000 is_a: UBERON:0000000 ! processual entity relationship: part_of UBERON:0000104 ! life cycle property_value: IAO:0000116 "this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here" xsd:string property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 property_value: UBPROP:0000012 "the WBls class 'all stages' belongs here as it is the superclass of other WBls stages" xsd:string property_value: UBPROP:0000012 "we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage" xsd:string [Term] id: UBERON:0000465 name: material anatomical entity namespace: uberon def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: upper_level xref: AAO:0010264 xref: AEO:0000006 xref: BILA:0000006 xref: CARO:0000006 xref: EHDAA2:0003006 xref: FBbt:00007016 xref: FMA:67165 xref: HAO:0000006 xref: TAO:0001836 xref: TGMA:0001826 xref: VHOG:0001721 is_a: BFO:0000040 ! material entity is_a: UBERON:0001062 ! anatomical entity property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0001062 name: anatomical entity namespace: uberon def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737] subset: common_anatomy subset: upper_level xref: AAO:0010841 xref: AEO:0000000 xref: BILA:0000000 xref: BIRNLEX:6 xref: CARO:0000000 xref: EHDAA2:0002229 xref: FBbt:10000000 xref: FMA:62955 xref: HAO:0000000 xref: MA:0000001 xref: NCIT:C12219 xref: TAO:0100000 xref: TGMA:0001822 xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance"} xref: WBbt:0000100 xref: XAO:0000000 xref: ZFA:0100000 is_a: BFO:0000004 ! independent continuant property_value: RO:0002175 NCBITaxon:33090 property_value: RO:0002175 NCBITaxon:33208 property_value: RO:0002175 NCBITaxon:4751 [Typedef] id: BFO:0000054 name: realized in comment: Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process property_value: IAO:0000111 "realized in" xsd:string property_value: IAO:0000112 "this disease is realized in this disease course" xsd:string property_value: IAO:0000112 "this fragility is realized in this shattering" xsd:string property_value: IAO:0000112 "this investigator role is realized in this investigation" xsd:string property_value: IAO:0000118 "is realized by" xsd:string property_value: IAO:0000118 "realized_in" xsd:string property_value: IAO:0000600 "[copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl domain: BFO:0000017 ! realizable entity range: BFO:0000015 ! process inverse_of: BFO:0000055 ! realizes [Typedef] id: BFO:0000055 name: realizes comment: Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process property_value: IAO:0000111 "realizes" xsd:string property_value: IAO:0000112 "this disease course realizes this disease" xsd:string property_value: IAO:0000112 "this investigation realizes this investigator role" xsd:string property_value: IAO:0000112 "this shattering realizes this fragility" xsd:string property_value: IAO:0000600 "to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/iao.owl domain: BFO:0000015 ! process range: BFO:0000017 ! realizable entity [Typedef] id: IDO:0000660 name: results_in [Typedef] id: PHIPO:0000304 name: qualifier comment: Used in FYPO as described in PATO best practices; placeholder relation to indicate normality/abnormality. which namespace? do we need all 3 triplicated again? created_by: alaynecuzick creation_date: 2018-10-12T13:24:02Z [Typedef] id: RO:0000052 name: characteristic of name: inheres in def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." [] def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" [] comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. property_value: IAO:0000111 "inheres in" xsd:string property_value: IAO:0000112 "this fragility inheres in this vase" xsd:string property_value: IAO:0000112 "this fragility is a characteristic of this vase" xsd:string property_value: IAO:0000112 "this red color inheres in this apple" xsd:string property_value: IAO:0000112 "this red color is a characteristic of this apple" xsd:string property_value: IAO:0000116 "A dependent inheres in its bearer at all times for which the dependent exists." xsd:string property_value: IAO:0000118 "inheres_in" xsd:string property_value: RO:0001900 RO:0001901 is_functional: true is_a: RO:0002314 ! characteristic of part of inverse_of: bearer_of ! bearer of [Typedef] id: RO:0000079 name: function of def: "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence" [] comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. property_value: IAO:0000112 "this catalysis function is a function of this enzyme" xsd:string property_value: IAO:0000116 "A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists." xsd:string property_value: IAO:0000118 "function_of" xsd:string property_value: IAO:0000118 "is function of" xsd:string domain: BFO:0000034 ! function is_a: RO:0000052 ! inheres in inverse_of: RO:0000085 ! has function [Typedef] id: RO:0000080 name: quality of def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" [] comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. property_value: IAO:0000112 "this red color is a quality of this apple" xsd:string property_value: IAO:0000116 "A quality inheres in its bearer at all times for which the quality exists." xsd:string property_value: IAO:0000118 "is quality of" xsd:string property_value: IAO:0000118 "quality_of" xsd:string is_a: RO:0000052 ! inheres in inverse_of: has_quality ! has quality [Typedef] id: RO:0000081 name: role of def: "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence" [] comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. property_value: IAO:0000112 "this investigator role is a role of this person" xsd:string property_value: IAO:0000116 "A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists." xsd:string property_value: IAO:0000118 "is role of" xsd:string property_value: IAO:0000118 "role_of" xsd:string is_a: RO:0000052 ! inheres in inverse_of: RO:0000087 ! has role [Typedef] id: RO:0000085 name: has function def: "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence" [] property_value: IAO:0000112 "this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)" xsd:string property_value: IAO:0000116 "A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists." xsd:string property_value: IAO:0000118 "has_function" xsd:string domain: BFO:0000004 ! independent continuant range: BFO:0000034 ! function is_a: bearer_of ! bearer of [Typedef] id: RO:0000087 name: has role def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" [] property_value: IAO:0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)" xsd:string property_value: IAO:0000116 "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists." xsd:string property_value: IAO:0000118 "has_role" xsd:string domain: BFO:0000004 ! independent continuant range: BFO:0000023 ! role is_a: bearer_of ! bearer of [Typedef] id: RO:0000091 name: has disposition def: "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence" [] domain: BFO:0000004 ! independent continuant range: BFO:0000016 ! disposition is_a: bearer_of ! bearer of inverse_of: RO:0000092 ! disposition of [Typedef] id: RO:0000092 name: disposition of def: "inverse of has disposition" [] comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. subset: RO:0002259 is_a: RO:0000052 ! inheres in [Typedef] id: RO:0002015 name: has positive regulatory component activity def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." [] comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'. is_a: has_regulatory_component_activity ! has regulatory component activity is_a: positively_regulated_by ! positively regulated by created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-05-24T09:31:17Z [Typedef] id: RO:0002017 name: has component activity comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B. is_a: RO:0002018 ! has component process created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-05-24T09:44:33Z [Typedef] id: RO:0002018 name: has component process def: "w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] domain: BFO:0000015 ! process range: BFO:0000015 ! process is_a: has_component ! has component created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-05-24T09:49:21Z [Typedef] id: RO:0002022 name: directly regulated by comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="GOC:dos"} comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="https://orcid.org/0000-0002-7073-9172"} is_a: regulated_by ! regulated by inverse_of: directly_regulates ! directly regulates created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-09-17T13:52:24Z [Typedef] id: RO:0002023 name: directly negatively regulated by def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [GOC:dos] def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [https://orcid.org/0000-0002-7073-9172] is_a: RO:0002022 ! directly regulated by inverse_of: directly_negatively_regulates ! directly negatively regulates created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-09-17T13:52:38Z [Typedef] id: RO:0002024 name: directly positively regulated by def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [GOC:dos] def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [https://orcid.org/0000-0002-7073-9172] is_a: RO:0002022 ! directly regulated by inverse_of: directly_positively_regulates ! directly positively regulates created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-09-17T13:52:47Z [Typedef] id: RO:0002025 name: has effector activity def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [GOC:dos] def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [https://orcid.org/0000-0002-7073-9172] comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations. is_functional: true is_a: RO:0002017 ! has component activity created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-09-22T14:14:36Z [Typedef] id: RO:0002086 name: ends after comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002222 name: temporally related to comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. subset: ro-eco property_value: http://purl.org/dc/terms/source "https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1" xsd:anyURI property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 https://en.wikipedia.org/wiki/Allen%27s_interval_algebra property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent [Typedef] id: RO:0002263 name: acts upstream of def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: IAO:0000112 "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." xsd:string property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of holds_over_chain: RO:0002327 causally_upstream_of is_a: RO:0002264 ! acts upstream of or within [Typedef] id: RO:0002264 name: acts upstream of or within def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term synonym: "affects" RELATED [] property_value: IAO:0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." xsd:string property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within" xsd:anyURI holds_over_chain: RO:0002327 causally_upstream_of_or_within is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002314 name: characteristic of part of def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." [] property_value: IAO:0000116 "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "inheres in part of" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 property_value: RO:0001900 RO:0001901 property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: RO:0002502 ! depends on transitive_over: part_of ! part_of [Typedef] id: RO:0002320 name: evolutionarily related to def: "A relationship that holds via some environmental process" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution." xsd:string [Typedef] id: RO:0002323 name: mereotopologically related to def: "A mereological relationship or a topological relationship" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" xsd:string property_value: RO:0001900 RO:0001901 [Typedef] id: RO:0002324 name: developmentally related to def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development" xsd:string [Typedef] id: RO:0002327 name: enables def: "c enables p iff c is capable of p and c acts to execute p." [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: IAO:0000112 "a particular instances of akt-2 enables some instance of protein kinase activity" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "catalyzes" xsd:string property_value: IAO:0000118 "executes" xsd:string property_value: IAO:0000118 "has" xsd:string property_value: IAO:0000118 "is catalyzing" xsd:string property_value: IAO:0000118 "is executing" xsd:string property_value: IAO:0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string property_value: seeAlso "https://wiki.geneontology.org/Enables" xsd:anyURI is_a: capable_of ! capable of inverse_of: RO:0002333 ! enabled by transitive_over: has_part ! has part transitive_over: RO:0002017 ! has component activity [Typedef] id: RO:0002329 name: part of structure that is capable of def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "false" xsd:boolean holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"} is_a: functionally_related_to ! functionally related to [Typedef] id: RO:0002331 name: involved in def: "c involved_in p if and only if c enables some process p', and p' is part of p" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "actively involved in" xsd:string property_value: IAO:0000118 "enables part of" xsd:string property_value: seeAlso "https://wiki.geneontology.org/Involved_in" xsd:anyURI property_value: seeAlso Involved:in holds_over_chain: RO:0002327 part_of is_a: participates_in ! participates in is_a: RO:0002431 ! involved in or involved in regulation of transitive_over: part_of ! part_of [Typedef] id: RO:0002333 name: enabled by def: "inverse of enables" [] subset: http://purl.obolibrary.org/obo/valid_for_gocam property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: seeAlso "https://wiki.geneontology.org/Enabled_by" xsd:anyURI is_a: functionally_related_to ! functionally related to is_a: has_participant ! has participant [Typedef] id: RO:0002337 name: related via localization to def: "A relationship that holds via some process of localization" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "Do not use this relation directly. It is a grouping relation." xsd:string domain: BFO:0000015 ! process range: BFO:0000002 ! continuant [Typedef] id: RO:0002354 name: formed as result of property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: output_of ! output of [Typedef] id: RO:0002407 name: indirectly positively regulates def: "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "indirectly activates" xsd:string property_value: RO:0002579 RO:0002213 property_value: seeAlso "https://wiki.geneontology.org/Indirectly_positively_regulates" xsd:anyURI holds_over_chain: directly_positively_regulates directly_positively_regulates holds_over_chain: directly_positively_regulates RO:0002407 holds_over_chain: RO:0002409 RO:0002409 is_transitive: true is_a: positively_regulates ! positively regulates is_a: RO:0012012 ! indirectly regulates transitive_over: directly_positively_regulates ! directly positively regulates [Typedef] id: RO:0002409 name: indirectly negatively regulates def: "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "indirectly inhibits" xsd:string property_value: RO:0002579 RO:0002212 property_value: seeAlso "https://wiki.geneontology.org/Indirectly_negatively_regulates" xsd:anyURI holds_over_chain: directly_negatively_regulates directly_negatively_regulates holds_over_chain: directly_negatively_regulates RO:0002409 is_transitive: true is_a: negatively_regulates ! negatively regulates is_a: RO:0012012 ! indirectly regulates transitive_over: directly_negatively_regulates ! directly negatively regulates [Typedef] id: RO:0002410 name: causally related to def: "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." [https://en.wikipedia.org/wiki/Causality] property_value: IAO:0000116 "This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.\n\nTo define causal relations in an activity-flow type network, we make use of 3 primitives:\n\n * Temporal: how do the intervals of the two occurrents relate? \n * Is the causal relation regulatory?\n * Is the influence positive or negative?\n\nThe first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.\n\nFor the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.\n\nFor the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.\n\nEach of these 3 primitives can be composed to yield a cross-product of different relation types." xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string [Typedef] id: RO:0002428 name: involved in regulation of def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 holds_over_chain: RO:0002327 regulates holds_over_chain: RO:0002331 regulates is_a: RO:0002263 ! acts upstream of is_a: RO:0002431 ! involved in or involved in regulation of [Typedef] id: RO:0002429 name: involved in positive regulation of def: "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: RO:0004049 RO:0002428 holds_over_chain: RO:0002327 positively_regulates holds_over_chain: RO:0002331 positively_regulates is_a: RO:0002428 ! involved in regulation of [Typedef] id: RO:0002430 name: involved in negative regulation of def: "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: RO:0004050 RO:0002428 holds_over_chain: RO:0002327 negatively_regulates holds_over_chain: RO:0002331 negatively_regulates is_a: RO:0002428 ! involved in regulation of [Typedef] id: RO:0002431 name: involved in or involved in regulation of def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" [] property_value: IAO:0000116 "OWL does not allow defining object properties via a Union" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "involved in or reguates" xsd:string is_a: functionally_related_to ! functionally related to is_a: RO:0002264 ! acts upstream of or within is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002432 name: is active in def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [GOC:cjm, GOC:dos] def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-7073-9172] synonym: "enables activity in" EXACT [] property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "executes activity in" xsd:string property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"} is_a: functionally_related_to ! functionally related to is_a: overlaps ! overlaps [Typedef] id: RO:0002434 name: interacts with def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." [] subset: ro-eco synonym: "in pairwise interaction with" EXACT [] property_value: closeMatch "http://purl.obolibrary.org/obo/MI_0914" xsd:anyURI property_value: IAO:0000116 "Considering relabeling as 'pairwise interacts with'" xsd:anyURI property_value: IAO:0000116 "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." xsd:string property_value: seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/" xsd:anyURI domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_symmetric: true [Typedef] id: RO:0002436 name: molecularly interacts with def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." [] property_value: closeMatch "http://purl.obolibrary.org/obo/MI_0915" xsd:anyURI property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "binds" xsd:string property_value: IAO:0000118 "molecularly binds with" xsd:string property_value: seeAlso ECO:0000353 is_symmetric: true is_a: RO:0002434 ! interacts with [Typedef] id: RO:0002447 name: phosphorylates property_value: IAO:0000116 "Axiomatization to GO to be added later" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y." xsd:string is_a: RO:0002436 ! molecularly interacts with [Typedef] id: RO:0002448 name: directly regulates activity of def: "The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.\n\nA and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B." [] synonym: "molecularly controls" EXACT [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002436 ! molecularly interacts with is_a: RO:0011002 ! regulates activity of [Typedef] id: RO:0002449 name: directly negatively regulates activity of def: "The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." [] synonym: "molecularly decreases activity of" EXACT [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431 property_value: IAO:0000118 "directly inhibits" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002448 ! directly regulates activity of [Typedef] id: RO:0002450 name: directly positively regulates activity of def: "The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." [] synonym: "molecularly increases activity of" EXACT [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431 property_value: IAO:0000118 "directly activates" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002448 ! directly regulates activity of [Typedef] id: RO:0002464 name: helper property (not for use in curation) property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning." xsd:string [Typedef] id: RO:0002479 name: has part that occurs in def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." [] subset: ro-eco property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"} [Typedef] id: RO:0002481 name: is kinase activity property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: RO:0002564 ! molecular interaction relation helper property [Typedef] id: RO:0002487 name: relation between physical entity and a process or stage property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage." xsd:string domain: BFO:0000004 ! independent continuant range: BFO:0000003 ! occurrent [Typedef] id: RO:0002500 name: causal agent in process def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_a: RO:0002595 ! causal relation between material entity and a process inverse_of: process_has_causal_agent ! process has causal agent [Typedef] id: RO:0002501 name: causal relation between processes def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002502 name: depends on property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: seeAlso BFO:0000169 [Typedef] id: RO:0002503 name: towards def: "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" [] property_value: IAO:0000116 "This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C." xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 is_a: RO:0002502 ! depends on [Typedef] id: RO:0002506 name: causal relation between entities property_value: IAO:0000116 "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002559 name: causally influenced by property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "causally influenced by (entity-centric)" xsd:string is_a: RO:0002506 ! causal relation between entities inverse_of: RO:0002566 ! causally influences [Typedef] id: RO:0002563 name: interaction relation helper property property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29 property_value: seeAlso "http://purl.obolibrary.org/obo/ro/docs/interaction-relations/" xsd:anyURI is_a: RO:0002464 ! helper property (not for use in curation) [Typedef] id: RO:0002564 name: molecular interaction relation helper property property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: RO:0002563 ! interaction relation helper property [Typedef] id: RO:0002566 name: causally influences def: "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." [] property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "causally influences (entity-centric)" xsd:string domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: RO:0002506 ! causal relation between entities [Typedef] id: RO:0002573 name: has modifier def: "A relation that holds between an attribute or a qualifier and another attribute." [] subset: ro-eco property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 property_value: IAO:0000232 "This relation is intended to be used in combination with PATO, to be able to refine PATO quality classes using modifiers such as 'abnormal' and 'normal'. It has yet to be formally aligned into an ontological framework; it's not clear what the ontological status of the \"modifiers\" are." xsd:string domain: BFO:0000020 ! specifically dependent continuant range: BFO:0000020 ! specifically dependent continuant [Typedef] id: RO:0002584 name: has part structure that is capable of def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" [] property_value: IAO:0000112 "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 holds_over_chain: has_part capable_of is_a: functionally_related_to ! functionally related to is_a: RO:0002595 ! causal relation between material entity and a process [Typedef] id: RO:0002586 name: results in breakdown of def: "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" [] is_a: has_input ! has input [Typedef] id: RO:0002595 name: causal relation between material entity and a process def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." [] property_value: IAO:0000116 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations domain: BFO:0000040 ! material entity range: BFO:0000015 ! process is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002596 name: capable of regulating def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." [] property_value: IAO:0000112 "pyrethroid -> growth" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: capable_of regulates is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002597 name: capable of negatively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: capable_of negatively_regulates is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0002598 name: capable of positively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." [] property_value: IAO:0000112 "renin -> arteriolar smooth muscle contraction" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: capable_of positively_regulates is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0004031 name: enables subfunction def: "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." [] holds_over_chain: RO:0002327 has_part is_a: functionally_related_to ! functionally related to created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-01-25T23:20:13Z [Typedef] id: RO:0004032 name: acts upstream of or within, positive effect subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: RO:0004049 RO:0002264 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect" xsd:anyURI holds_over_chain: RO:0002327 RO:0004047 is_a: RO:0002264 ! acts upstream of or within created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-01-26T23:49:30Z [Typedef] id: RO:0004033 name: acts upstream of or within, negative effect subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: RO:0004050 RO:0002264 property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect" xsd:anyURI holds_over_chain: RO:0002327 RO:0004046 is_a: RO:0002264 ! acts upstream of or within created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-01-26T23:49:51Z [Typedef] id: RO:0004034 name: acts upstream of, positive effect def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: RO:0004049 RO:0002263 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect" xsd:anyURI holds_over_chain: RO:0002327 causally_upstream_of,_positive_effect is_a: RO:0002263 ! acts upstream of is_a: RO:0004032 ! acts upstream of or within, positive effect created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-01-26T23:53:14Z [Typedef] id: RO:0004035 name: acts upstream of, negative effect def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" [] subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term property_value: RO:0004050 RO:0002263 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect" xsd:anyURI holds_over_chain: RO:0002327 causally_upstream_of,_negative_effect is_a: RO:0002263 ! acts upstream of is_a: RO:0004033 ! acts upstream of or within, negative effect created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-01-26T23:53:22Z [Typedef] id: RO:0004046 name: causally upstream of or within, negative effect property_value: RO:0004050 RO:0002418 property_value: seeAlso "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect" xsd:anyURI is_a: causally_upstream_of_or_within ! causally upstream of or within created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-03-13T23:55:05Z [Typedef] id: RO:0004047 name: causally upstream of or within, positive effect property_value: RO:0004049 RO:0002418 property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect is_a: causally_upstream_of_or_within ! causally upstream of or within created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-03-13T23:55:19Z [Typedef] id: RO:0011002 name: regulates activity of def: "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." [] property_value: IAO:0000117 https://orcid.org/0000-0003-4639-4431 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002566 ! causally influences [Typedef] id: RO:0012011 name: indirectly causally upstream of def: "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." [] is_a: causally_upstream_of ! causally upstream of created_by: https://orcid.org/0000-0003-1813-6857 created_by: pg creation_date: 2022-09-26T06:07:17Z [Typedef] id: RO:0012012 name: indirectly regulates def: "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." [] is_a: regulates ! regulates is_a: RO:0012011 ! indirectly causally upstream of created_by: https://orcid.org/0000-0003-1813-6857 created_by: pg creation_date: 2022-09-26T06:08:01Z [Typedef] id: RO:0015006 name: different in magnitude relative to def: "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] domain: PATO:0000001 ! quality range: PATO:0000001 ! quality [Typedef] id: RO:0015007 name: increased in magnitude relative to def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_a: RO:0015006 ! different in magnitude relative to [Typedef] id: RO:0015008 name: decreased in magnitude relative to def: "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_a: RO:0015006 ! different in magnitude relative to [Typedef] id: RO:0015010 name: has relative magnitude [Typedef] id: RO:0015012 name: reciprocal of def: "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." [https://orcid.org/0000-0002-6601-2165] comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality. [Typedef] id: RO:0017001 name: device utilizes material def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." [] synonym: "utilizes" BROAD [] property_value: IAO:0000112 "A diagnostic testing device utilizes a specimen." xsd:string property_value: IAO:0000117 https://orcid.org/0000-0001-9625-1899 property_value: IAO:0000117 https://orcid.org/0000-0003-2620-0345 property_value: IAO:0000232 "A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input." xsd:string property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-relations/issues/497" xsd:string holds_over_chain: capable_of has_input creation_date: 2021-11-08T12:00:00Z [Typedef] id: bearer_of name: bearer of name: has characteristic namespace: external def: "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence" [] def: "Inverse of characteristic_of" [] xref: RO:0000053 property_value: IAO:0000111 "bearer of" xsd:string property_value: IAO:0000112 "this apple is bearer of this red color" xsd:string property_value: IAO:0000112 "this vase is bearer of this fragility" xsd:string property_value: IAO:0000116 "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist." xsd:string property_value: IAO:0000118 "bearer_of" xsd:string property_value: IAO:0000118 "is bearer of" xsd:string property_value: RO:0001900 RO:0001901 range: BFO:0000020 ! specifically dependent continuant is_inverse_functional: true [Typedef] id: capable_of name: capable of namespace: external namespace: uberon def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " [] subset: ro-eco xref: RO:0002215 property_value: IAO:0000112 "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)" xsd:string property_value: IAO:0000112 "osteoclast SubClassOf 'capable of' some 'bone resorption'" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "has function realized in" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20123131 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/21208450 property_value: IAO:0000232 "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." xsd:string domain: BFO:0000004 ! independent continuant range: BFO:0000015 ! process is_a: capable_of_part_of ! capable of part of [Typedef] id: capable_of_part_of name: capable of part of namespace: external namespace: uberon def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." [] xref: RO:0002216 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "has function in" xsd:string property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: functionally_related_to ! functionally related to is_a: RO:0002500 ! causal agent in process [Typedef] id: causally_downstream_of name: causally downstream of namespace: external def: "inverse of upstream of" [] xref: RO:0002404 property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: causally_downstream_of_or_within ! causally downstream of or within is_a: preceded_by ! preceded by inverse_of: causally_upstream_of ! causally upstream of [Typedef] id: causally_downstream_of_or_within name: causally downstream of or within namespace: external def: "inverse of causally upstream of or within" [] subset: RO:0002259 xref: RO:0002427 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_transitive: true is_a: RO:0002501 ! causal relation between processes [Typedef] id: causally_upstream_of name: causally upstream of namespace: external def: "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002411 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_transitive: true is_a: causally_upstream_of_or_within ! causally upstream of or within is_a: precedes ! precedes [Typedef] id: causally_upstream_of,_negative_effect name: causally upstream of, negative effect namespace: external def: "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002305 property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165 property_value: RO:0004050 RO:0002411 property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_negative_effect is_a: causally_upstream_of ! causally upstream of is_a: RO:0004046 ! causally upstream of or within, negative effect [Typedef] id: causally_upstream_of,_positive_effect name: causally upstream of, positive effect namespace: external def: "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." [] comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002304 property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165 property_value: RO:0004049 RO:0002411 property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_positive_effect is_a: causally_upstream_of ! causally upstream of is_a: RO:0004047 ! causally upstream of or within, positive effect [Typedef] id: causally_upstream_of_or_within name: causally upstream of or within namespace: external def: "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." [] synonym: "affects" RELATED [] xref: RO:0002418 property_value: IAO:0000116 "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "influences (processual)" xsd:string is_transitive: true is_a: RO:0002501 ! causal relation between processes inverse_of: causally_downstream_of_or_within ! causally downstream of or within [Typedef] id: contains_process name: contains process namespace: uberon def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant xref: BFO:0000067 property_value: IAO:0000111 "site of" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Typedef] id: dc-creator name: creator namespace: uberon xref: http://purl.org/dc/elements/1.1/creator is_metadata_tag: true [Typedef] id: dc-description name: description namespace: uberon xref: http://purl.org/dc/elements/1.1/description is_metadata_tag: true [Typedef] id: dc-title name: title namespace: uberon xref: http://purl.org/dc/elements/1.1/title is_metadata_tag: true [Typedef] id: dcterms-license name: license namespace: uberon xref: http://purl.org/dc/terms/license is_metadata_tag: true [Typedef] id: decreased_in_magnitude_relative_to name: obsolete decreased_in_magnitude_relative_to namespace: quality def: "OBSOLETE. q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] comment: Refer to https://github.com/pato-ontology/pato/issues/454 for obsoletion reason. This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_transitive: true is_obsolete: true replaced_by: RO:0015008 [Typedef] id: directly_negatively_regulates name: directly negatively regulates namespace: external def: "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002630 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly negatively regulates (process to process)" xsd:string property_value: RO:0004050 RO:0002578 property_value: seeAlso "https://wiki.geneontology.org/Directly_negatively_regulates" xsd:anyURI is_a: directly_regulates ! directly regulates is_a: negatively_regulates ! negatively regulates [Typedef] id: directly_positively_regulates name: directly positively regulates namespace: external def: "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002629 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly positively regulates (process to process)" xsd:string property_value: RO:0004049 RO:0002578 property_value: seeAlso "https://wiki.geneontology.org/Directly_positively_regulates" xsd:anyURI is_a: directly_regulates ! directly regulates is_a: positively_regulates ! positively regulates [Typedef] id: directly_regulates name: directly regulates namespace: external def: "p directly regulates q iff p is immediately causally upstream of q and p regulates q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002578 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly regulates (processual)" xsd:string property_value: RO:0002575 RO:0002211 is_a: immediately_causally_upstream_of ! immediately causally upstream of is_a: regulates ! regulates [Typedef] id: ends name: ends namespace: uberon def: "inverse of ends with" [] subset: ro-eco xref: RO:0002229 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: part_of ! part_of is_a: RO:0002222 ! temporally related to inverse_of: ends_with ! ends with [Typedef] id: ends_during name: ends during namespace: external xref: RO:0002093 [Typedef] id: ends_with name: ends with namespace: external namespace: uberon def: "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco xref: RO:0002230 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "finished by" xsd:string is_transitive: true is_a: has_part ! has part is_a: RO:0002222 ! temporally related to [Typedef] id: existence_ends_during_or_before name: existence ends during or before namespace: uberon def: "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. xref: RO:0002497 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 holds_over_chain: part_of existence_ends_during_or_before is_a: RO:0002487 ! relation between physical entity and a process or stage transitive_over: part_of ! part_of transitive_over: precedes ! precedes [Typedef] id: functionally_related_to name: functionally related to namespace: uberon def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." [] xref: RO:0002328 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" xsd:string [Typedef] id: happens_during name: happens during namespace: external xref: RO:0002092 is_transitive: true is_a: ends_during ! ends during [Typedef] id: has_component name: has component namespace: external namespace: uberon def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] subset: ro-eco xref: RO:0002180 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." xsd:string property_value: IAO:0000232 "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit." xsd:string property_value: RO:0001900 RO:0001901 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:Componency is_a: has_part ! has part [Typedef] id: has_end_location name: has end location namespace: external def: "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" [] subset: ro-eco xref: RO:0002232 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "ends with process that occurs in" xsd:string domain: BFO:0000015 ! process range: BFO:0000004 ! independent continuant holds_over_chain: ends_with occurs_in is_a: RO:0002479 ! has part that occurs in [Typedef] id: has_input name: has input namespace: external def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam subset: ro-eco xref: RO:0002233 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "consumes" xsd:string property_value: seeAlso "https://wiki.geneontology.org/Has_input" xsd:anyURI domain: BFO:0000015 ! process holds_over_chain: starts_with has_input is_a: has_participant ! has participant inverse_of: input_of ! input of [Typedef] id: has_negative_regulatory_component_activity name: has negative regulatory component activity namespace: external def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." [] comment: By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'. xref: RO:0002014 is_a: has_regulatory_component_activity ! has regulatory component activity is_a: negatively_regulated_by ! negatively regulated by created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-05-24T09:31:01Z [Typedef] id: has_output name: has output namespace: external def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam subset: ro-eco xref: RO:0002234 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "produces" xsd:string holds_over_chain: ends_with has_output is_a: has_participant ! has participant inverse_of: output_of ! output of [Typedef] id: has_part name: has part name: has_part namespace: external namespace: quality namespace: sequence namespace: uberon def: "a core relation that holds between a whole and its part" [] def: "Inverse of part_of." [http://precedings.nature.com/documents/3495/version/1] comment: Example: operon has_part gene. subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: BFO:0000051 property_value: IAO:0000111 "has part" xsd:string property_value: IAO:0000112 "my body has part my brain (continuant parthood, two material entities)" xsd:string property_value: IAO:0000112 "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)" xsd:string property_value: IAO:0000112 "this year has part this day (occurrent parthood)" xsd:string property_value: IAO:0000116 "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." xsd:string property_value: IAO:0000118 "has_part" xsd:string property_value: RO:0001900 RO:0001901 is_transitive: true is_a: overlaps ! overlaps [Typedef] id: has_participant name: has participant namespace: external def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] xref: RO:0000057 property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string property_value: IAO:0000111 "has participant" xsd:string property_value: IAO:0000112 "this blood coagulation has participant this blood clot" xsd:string property_value: IAO:0000112 "this investigation has participant this investigator" xsd:string property_value: IAO:0000112 "this process has participant this input material (or this output material)" xsd:string property_value: IAO:0000116 "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string property_value: IAO:0000118 "has_participant" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000002 ! continuant holds_over_chain: has_part has_participant [Typedef] id: has_primary_input name: has primary input namespace: external def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:cjm, GOC:dph, GOC:kva, GOC:pt] {comment="PMID:27812932"} subset: http://purl.obolibrary.org/obo/valid_for_go_ontology xref: RO:0004009 is_a: has_input ! has input is_a: has_primary_input_or_output ! has primary input or output created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-12-13T11:26:56Z [Typedef] id: has_primary_input_or_output name: has primary input or output namespace: external def: "p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c." [] subset: http://purl.obolibrary.org/obo/valid_for_go_ontology xref: RO:0004007 is_a: has_participant ! has participant created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-12-13T11:26:17Z [Typedef] id: has_primary_output name: has primary output namespace: external def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [GOC:cjm, GOC:dph, GOC:kva, GOC:pt] {comment="PMID:27812932"} subset: http://purl.obolibrary.org/obo/valid_for_go_ontology xref: RO:0004008 is_a: has_output ! has output is_a: has_primary_input_or_output ! has primary input or output created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-12-13T11:26:32Z [Typedef] id: has_quality name: has quality namespace: uberon def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" [] xref: RO:0000086 property_value: IAO:0000112 "this apple has quality this red color" xsd:string property_value: IAO:0000116 "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist." xsd:string property_value: IAO:0000118 "has_quality" xsd:string range: BFO:0000019 ! quality is_a: bearer_of ! bearer of [Typedef] id: has_regulatory_component_activity name: has regulatory component activity namespace: external def: "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." [] xref: RO:0002013 is_a: regulated_by ! regulated by is_a: RO:0002017 ! has component activity created_by: dos created_by: https://orcid.org/0000-0002-7073-9172 creation_date: 2017-05-24T09:30:46Z [Typedef] id: has_relative_magnitude name: obsolete has_relative_magnitude namespace: quality comment: Refer to https://github.com/pato-ontology/pato/issues/454. is_obsolete: true replaced_by: RO:0015010 [Typedef] id: has_start_location name: has start location namespace: external def: "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" [] subset: ro-eco xref: RO:0002231 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "starts with process that occurs in" xsd:string domain: BFO:0000015 ! process range: BFO:0000004 ! independent continuant holds_over_chain: starts_with occurs_in is_a: RO:0002479 ! has part that occurs in [Typedef] id: has_target_end_location name: has target end location namespace: external def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002339 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: results_in_transport_to_from_or_in ! results in transport to from or in transitive_over: part_of ! part_of [Typedef] id: has_target_start_location name: has target start location namespace: external def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002338 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: results_in_transport_to_from_or_in ! results in transport to from or in transitive_over: part_of ! part_of [Typedef] id: immediately_causally_downstream_of name: immediately causally downstream of namespace: external xref: RO:0002405 property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: causally_downstream_of ! causally downstream of is_a: immediately_preceded_by ! immediately preceded by inverse_of: immediately_causally_upstream_of ! immediately causally upstream of [Typedef] id: immediately_causally_upstream_of name: immediately causally upstream of namespace: external def: "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." [] xref: RO:0002412 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: RO:0002575 RO:0002411 is_a: causally_upstream_of ! causally upstream of is_a: immediately_precedes ! immediately precedes [Typedef] id: immediately_preceded_by name: immediately preceded by namespace: external namespace: uberon comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) xref: RO:0002087 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "starts_at_end_of" xsd:string holds_over_chain: starts_with ends_with is_a: preceded_by ! preceded by inverse_of: immediately_precedes ! immediately precedes [Typedef] id: immediately_precedes name: immediately precedes namespace: external comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) subset: ro-eco xref: RO:0002090 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172 property_value: IAO:0000118 "ends_at_start_of" xsd:string property_value: IAO:0000118 "meets" xsd:string property_value: RO:0002575 BFO:0000063 holds_over_chain: ends_with starts_with is_a: precedes ! precedes [Typedef] id: in_taxon name: in taxon namespace: uberon def: "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." [] comment: Connects a biological entity to its taxon of origin. subset: ro-eco xref: RO:0002162 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0001-9227-417X property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/17921072 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20973947 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints holds_over_chain: capable_of in_taxon holds_over_chain: has_part in_taxon holds_over_chain: overlaps in_taxon holds_over_chain: part_of in_taxon holds_over_chain: produced_by in_taxon holds_over_chain: produces in_taxon holds_over_chain: results_in_developmental_progression_of in_taxon is_a: RO:0002320 ! evolutionarily related to [Typedef] id: increased_in_magnitude_relative_to name: obsolete increased_in_magnitude_relative_to namespace: quality def: "OBSOLETE. q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] comment: Refer to https://github.com/pato-ontology/pato/issues/454. This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_transitive: true is_obsolete: true replaced_by: RO:0015007 [Typedef] id: input_of name: input of namespace: uberon def: "inverse of has input" [] subset: ro-eco subset: RO:0002259 xref: RO:0002352 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: functionally_related_to ! functionally related to is_a: participates_in ! participates in [Typedef] id: negatively_regulated_by name: negatively regulated by namespace: external def: "inverse of negatively regulates" [] subset: RO:0002259 xref: RO:0002335 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: regulated_by ! regulated by [Typedef] id: negatively_regulates name: negatively regulates namespace: external def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002212 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "negatively regulates (process to process)" xsd:string property_value: RO:0004050 RO:0002211 holds_over_chain: ends_with negatively_regulates is_a: causally_upstream_of,_negative_effect ! causally upstream of, negative effect is_a: regulates ! regulates inverse_of: negatively_regulated_by ! negatively regulated by [Typedef] id: negatively_regulates_characteristic name: negatively regulates characteristic namespace: gene_ontology def: "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." [] xref: RO:0019002 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599 holds_over_chain: negatively_regulates positively_regulates_characteristic holds_over_chain: positively_regulates negatively_regulates_characteristic is_a: regulates_characteristic ! regulates characteristic [Typedef] id: occurs_in name: occurs in namespace: external def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: BFO:0000066 property_value: IAO:0000111 "occurs in" xsd:string property_value: IAO:0000118 "occurs_in" xsd:string property_value: IAO:0000118 "unfolds in" xsd:string property_value: IAO:0000118 "unfolds_in" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl property_value: seeAlso "https://wiki.geneontology.org/Occurs_in" xsd:anyURI domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: part_of occurs_in inverse_of: contains_process ! contains process transitive_over: part_of ! part_of [Typedef] id: only_in_taxon name: only in taxon namespace: uberon def: "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." [] xref: RO:0002160 property_value: IAO:0000112 "lactation SubClassOf 'only in taxon' some 'Mammalia'" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g.\n\n 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/17921072 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20973947 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints is_a: in_taxon ! in taxon [Typedef] id: output_of name: output of namespace: external namespace: uberon def: "inverse of has output" [] subset: ro-eco subset: RO:0002259 xref: RO:0002353 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: functionally_related_to ! functionally related to is_a: participates_in ! participates in [Typedef] id: overlaps name: overlaps namespace: external namespace: uberon def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam subset: ro-eco xref: RO:0002131 property_value: IAO:0000114 IAO:0000125 property_value: RO:0001900 RO:0001901 holds_over_chain: has_part overlaps holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} holds_over_chain: part_of part_of is_symmetric: true is_a: RO:0002323 ! mereotopologically related to transitive_over: part_of ! part_of expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" [] [Typedef] id: part_of name: part of name: part_of namespace: external namespace: quality namespace: uberon def: "a core relation that holds between a part and its whole" [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: BFO:0000050 property_value: IAO:0000111 "is part of" xsd:string property_value: IAO:0000112 "my brain is part of my body (continuant parthood, two material entities)" xsd:string property_value: IAO:0000112 "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)" xsd:string property_value: IAO:0000112 "this day is part of this year (occurrent parthood)" xsd:string property_value: IAO:0000116 "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: IAO:0000116 "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: IAO:0000116 "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: IAO:0000118 "part_of" xsd:string property_value: RO:0001900 RO:0001901 property_value: RO:0040042 BFO:0000002 property_value: RO:0040042 BFO:0000003 property_value: RO:0040042 BFO:0000004 property_value: RO:0040042 BFO:0000017 property_value: RO:0040042 BFO:0000019 property_value: RO:0040042 BFO:0000020 property_value: RO:0040042 BFO:0000031 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf property_value: seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" xsd:string property_value: seeAlso "https://wiki.geneontology.org/Part_of" xsd:anyURI is_transitive: true is_a: overlaps ! overlaps inverse_of: has_part ! has part [Typedef] id: participates_in name: participates in namespace: external namespace: uberon def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" [] xref: RO:0000056 property_value: IAO:0000111 "participates in" xsd:string property_value: IAO:0000112 "this blood clot participates in this blood coagulation" xsd:string property_value: IAO:0000112 "this input material (or this output material) participates in this process" xsd:string property_value: IAO:0000112 "this investigator participates in this investigation" xsd:string property_value: IAO:0000118 "participates_in" xsd:string domain: BFO:0000002 ! continuant range: BFO:0000003 ! occurrent inverse_of: has_participant ! has participant [Typedef] id: positively_regulated_by name: positively regulated by namespace: external def: "inverse of positively regulates" [] subset: RO:0002259 xref: RO:0002336 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: regulated_by ! regulated by [Typedef] id: positively_regulates name: positively regulates namespace: external def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002213 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "positively regulates (process to process)" xsd:string property_value: RO:0004049 RO:0002211 holds_over_chain: ends_with positively_regulates holds_over_chain: negatively_regulates negatively_regulates is_transitive: true is_a: causally_upstream_of,_positive_effect ! causally upstream of, positive effect is_a: regulates ! regulates inverse_of: positively_regulated_by ! positively regulated by [Typedef] id: positively_regulates_characteristic name: positively regulates characteristic namespace: gene_ontology def: "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." [] xref: RO:0019001 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599 holds_over_chain: positively_regulates positively_regulates_characteristic is_a: regulates_characteristic ! regulates characteristic [Typedef] id: preceded_by name: preceded by namespace: external namespace: uberon def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco xref: BFO:0000062 property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string property_value: IAO:0000111 "preceded by" xsd:string property_value: IAO:0000116 "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string property_value: IAO:0000118 "is preceded by" xsd:string property_value: IAO:0000118 "preceded_by" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: part_of preceded_by is_transitive: true is_a: RO:0002086 ! ends after inverse_of: precedes ! precedes [Typedef] id: precedes name: precedes namespace: external namespace: uberon def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco xref: BFO:0000063 property_value: IAO:0000111 "precedes" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: part_of precedes is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: process_has_causal_agent name: process has causal agent namespace: external def: "Inverse of 'causal agent in process'" [] xref: RO:0002608 property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_a: RO:0002410 ! causally related to [Typedef] id: produced_by name: produced by namespace: external namespace: uberon def: "a produced_by b iff some process that occurs_in b has_output a." [] subset: ro-eco xref: RO:0003001 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity [Typedef] id: produces name: produces namespace: external namespace: uberon def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." [] comment: Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue. subset: ro-eco xref: RO:0003000 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity inverse_of: produced_by ! produced by [Typedef] id: regulated_by name: regulated by namespace: external def: "inverse of regulates" [] subset: RO:0002259 xref: RO:0002334 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000589 "regulated by (processual)" xsd:string domain: BFO:0000015 ! process range: BFO:0000015 ! process is_transitive: true is_a: causally_downstream_of_or_within ! causally downstream of or within [Typedef] id: regulates name: regulates namespace: external def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002211 property_value: IAO:0000117 https://orcid.org/0000-0001-7476-6306 property_value: IAO:0000117 https://orcid.org/0000-0002-3837-8864 property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 "GO" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000232 "Regulation precludes parthood; the regulatory process may not be within the regulated process." xsd:string property_value: IAO:0000589 "regulates (processual)" xsd:string property_value: IAO:0000600 "false" xsd:boolean domain: BFO:0000015 ! process range: BFO:0000015 ! process holds_over_chain: directly_regulates directly_regulates holds_over_chain: ends_with regulates is_transitive: true is_a: causally_upstream_of ! causally upstream of inverse_of: regulated_by ! regulated by transitive_over: RO:0002025 ! has effector activity [Typedef] id: regulates_characteristic name: regulates characteristic namespace: gene_ontology def: "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." [] xref: RO:0019000 property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-8688-6599 domain: BFO:0000015 ! process range: PATO:0000001 ! quality holds_over_chain: regulates regulates_characteristic is_a: RO:0002410 ! causally related to [Typedef] id: results_in_assembly_of name: results in assembly of namespace: external subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002588 is_a: results_in_formation_of ! results in formation of is_a: results_in_organization_of ! results in organization of [Typedef] id: results_in_changes_to_anatomical_or_cellular_structure name: results in changes to anatomical or cellular structure namespace: external def: "p has anatomical participant c iff p has participant c, and c is an anatomical entity" [] xref: RO:0040036 is_a: has_participant ! has participant created_by: https://orcid.org/0000-0002-6601-2165 creation_date: 2018-09-26T01:08:58Z [Typedef] id: results_in_developmental_progression_of name: results in developmental progression of namespace: external def: "p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." [] xref: RO:0002295 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000116 "This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint." xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: seeAlso Ontology:extensions domain: GO:0008150 ! biological_process is_a: RO:0002324 ! developmentally related to [Typedef] id: results_in_disassembly_of name: results in disassembly of namespace: external xref: RO:0002590 is_a: results_in_organization_of ! results in organization of is_a: RO:0002586 ! results in breakdown of [Typedef] id: results_in_fission_of name: results in fission of name: results_in_fission_of namespace: external xref: GOREL:0002004 is_a: has_participant ! has participant [Typedef] id: results_in_formation_of name: results in formation of namespace: external subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0002297 property_value: IAO:0000112 "an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists." xsd:string property_value: IAO:0000112 "every \"endocardial cushion formation\" (GO:0003272) results_in_formation_of some \"endocardial cushion\" (UBERON:0002062)" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 "GOC:mtg_berkeley_2013" xsd:string is_a: has_output ! has output is_a: IDO:0000660 ! results_in is_a: results_in_developmental_progression_of ! results in developmental progression of inverse_of: RO:0002354 ! formed as result of [Typedef] id: results_in_fusion_of name: results in fusion of namespace: external subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: RO:0012008 is_a: results_in_organization_of ! results in organization of created_by: pg creation_date: 2021-02-26T07:28:29Z [Typedef] id: results_in_organization_of name: results in organization of namespace: external def: "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" [] xref: RO:0002592 is_a: has_participant ! has participant is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure [Typedef] id: results_in_transport_to_from_or_in name: results in transport to from or in namespace: external xref: RO:0002344 property_value: IAO:0000112 "'mitochondrial transport' results_in_transport_to_from_or_in some mitochondrion (GO:0005739)" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 is_a: RO:0002337 ! related via localization to [Typedef] id: starts name: starts namespace: uberon def: "inverse of starts with" [] subset: ro-eco xref: RO:0002223 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000119 "Allen" xsd:string is_a: part_of ! part_of is_a: RO:0002222 ! temporally related to inverse_of: starts_with ! starts with [Typedef] id: starts_with name: starts with namespace: external namespace: uberon def: "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco xref: RO:0002224 property_value: IAO:0000112 "Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165 property_value: IAO:0000118 "started by" xsd:string is_transitive: true is_a: has_part ! has part is_a: RO:0002222 ! temporally related to [Typedef] id: towards name: obsolete towards namespace: quality comment: Consider using RO:0002503 instead. See https://github.com/pato-ontology/pato/issues/454 is_obsolete: true replaced_by: RO:0002503