format-version: 1.2 data-version: releases/2020-03-28 subsetdef: abnormal_slim "Abnormal/normal slim" subsetdef: absent_slim "Absent/present slim" subsetdef: attribute_slim "Attribute slim" subsetdef: cell_quality "cell_quality" subsetdef: disposition_slim "Disposition slim" subsetdef: efo_slim "" subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_agr "AGR slim" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_drosophila "Drosophila GO slim" subsetdef: goslim_flybase_ribbon "FlyBase Drosophila GO ribbon slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_mouse "Mouse GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: mpath_slim "Pathology slim" subsetdef: pheno_slim "" subsetdef: relational_slim "Relational slim: types of quality that require an additional entity in order to exist" subsetdef: ro-eco "" subsetdef: RO:0002259 "" subsetdef: scalar_slim "Scalar slim" subsetdef: uberon_slim "" subsetdef: upper_level "" subsetdef: value_slim "Value slim" subsetdef: vertebrate_core "" ontology: planp property_value: http://purl.org/dc/elements/1.1/description "Planarian Phenotype Ontology is an ontology of phenotypes observed in the planarian Schmidtea mediterranea." xsd:string property_value: http://purl.org/dc/elements/1.1/title "Planarian Phenotype Ontology (PLANP)" xsd:string property_value: http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/3.0/ xsd:string [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] disjoint_from: BFO:0000003 ! occurrent relationship: part_of BFO:0000002 ! continuant [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] relationship: part_of BFO:0000003 ! occurrent [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000004 ! independent continuant [Term] id: BFO:0000006 name: spatial region is_a: BFO:0000141 ! immaterial entity [Term] id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000016 name: disposition is_a: BFO:0000017 ! realizable entity [Term] id: BFO:0000017 name: realizable entity def: "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." [] is_a: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000019 ! quality relationship: part_of BFO:0000017 ! realizable entity [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000019 ! quality [Term] id: BFO:0000020 name: specifically dependent continuant def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." [] is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000020 ! specifically dependent continuant [Term] id: BFO:0000031 name: generically dependent continuant def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." [] is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000031 ! generically dependent continuant [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant disjoint_from: BFO:0000141 ! immaterial entity [Term] id: BFO:0000141 name: immaterial entity is_a: BFO:0000004 ! independent continuant [Term] id: BSPO:0000005 name: anatomical surface namespace: spatial def: "A 2D surface of an anatomical continuant." [BSPO:cjm] comment: to be merged into CARO synonym: "surface" EXACT [] xref: FMA:24137 is_a: CARO:0000010 ! anatomical boundary [Term] id: BSPO:0000010 name: anatomical axis namespace: spatial def: "A straight line through space, intersecting an anatomical entity." [BSPO:cjm] comment: Axis directions are defined in terms of axes. xref: http://upload.wikimedia.org/wikipedia/commons/3/34/Anatomical_Directions_and_Axes.JPG is_a: CARO:0000008 ! anatomical line relationship: passes_through CARO:0000000 ! anatomical entity [Term] id: BSPO:0000013 name: anterior-posterior axis namespace: spatial def: "An axis that extends through an organism from head end to opposite end of body or tail." [BSPO:cjm] comment: In sponges, AP is used to indicate the direction of movement [in larval stage] (as it is in other metazoans that move, e.g., the basal bilaterians). [PM] synonym: "A-P axis" EXACT [] synonym: "anteroposterior axis" EXACT [] synonym: "AP axis" EXACT [] synonym: "cephalocaudal axis" NARROW [http://en.wikipedia.org/wiki/Anatomical_terms_of_location] synonym: "craniocaudal axis" NARROW vertebrate [] synonym: "longitudinal axis" RELATED [] synonym: "rostral/caudal" NARROW vertebrate [] synonym: "rostrocaudal axis" NARROW vertebrate [] is_a: BSPO:0000010 ! anatomical axis intersection_of: BSPO:0000010 ! anatomical axis intersection_of: orthogonal_to BSPO:0000018 ! transverse plane relationship: approximately_perpendicular_to BSPO:0000016 ! dorsal-ventral axis relationship: orthogonal_to BSPO:0000018 ! transverse plane [Term] id: BSPO:0000014 name: apical-basal axis relative to substrate namespace: spatial def: "An axis that extends through an organism or organism part from the part of the organism or organism part attached to a substrate (basal) to the furthest from the attachment (apical). Note that the apical-basal axis is often used for organismal parts where there is attachment via a basal lamina or other structure." [BSPO:mah] synonym: "apical/basal" EXACT [] synonym: "longitudinal axis" RELATED [] is_a: BSPO:0000010 ! anatomical axis [Term] id: BSPO:0000015 name: proximal-distal axis namespace: spatial def: "An axis that extends from the point of attachment of a structure (proximal) to the point furthest away from the plane of attachment (distal)." [BSPO:curators, http://en.wikipedia.org/wiki/Anatomical_terms_of_location] comment: In some communities, proximal and distal are used when specifying the position of parts of elements that are contained within the body, such as gill arches or vertebral spines. In these cases, use of the classes medial-lateral axis or medial-external axis are more appropriate. synonym: "proximal/distal" EXACT [] synonym: "proximodistal" EXACT [] is_a: BSPO:0000010 ! anatomical axis [Term] id: BSPO:0000016 name: dorsal-ventral axis namespace: spatial def: "An axis that is approximately perpendicular to the anterior-posterior axis and that extends through the horizontal plane of the body." [BSPO:curators] synonym: "anterior-posterior axis" NARROW human [] synonym: "D-V axis" EXACT [] synonym: "dorsoventral axis" EXACT [] synonym: "DV axis" EXACT [] is_a: BSPO:0000010 ! anatomical axis intersection_of: BSPO:0000010 ! anatomical axis intersection_of: orthogonal_to BSPO:0000019 ! horizontal plane relationship: orthogonal_to BSPO:0000019 ! horizontal plane [Term] id: BSPO:0000017 name: left-right axis namespace: spatial def: "An axis that bisects an organism from left to right sides of body, through a sagittal plane." [BSPO:cjm] synonym: "dextro-sinister axis" EXACT [] synonym: "L-R axis" EXACT [] synonym: "left to right axis" EXACT [] synonym: "LR axis" EXACT [] synonym: "R-L axis" EXACT [] synonym: "right to left axis" EXACT [] synonym: "right-left axis" EXACT [] synonym: "RL axis" EXACT [] is_a: BSPO:0000010 ! anatomical axis intersection_of: BSPO:0000010 ! anatomical axis intersection_of: orthogonal_to BSPO:0000417 ! sagittal plane relationship: orthogonal_to BSPO:0000417 ! sagittal plane [Term] id: BSPO:0000018 name: transverse plane namespace: spatial def: "Anatomical plane that divides body into anterior and posterior parts." [BSPO:mah] synonym: "axial plane" EXACT [] synonym: "axial section" EXACT [] synonym: "cross-section" RELATED [] synonym: "transverse section" EXACT [] xref: FMA:12247 is_a: BSPO:0000400 ! anatomical plane [Term] id: BSPO:0000019 name: horizontal plane namespace: spatial def: "Anatomical plane that divides bilateral body into dorsal and ventral parts." [BSPO:mah] synonym: "coronal section" RELATED [] synonym: "frontal plane" EXACT [] synonym: "frontal section" RELATED [] synonym: "horizontal anatomical plane" EXACT [FMA:52810] synonym: "horizontal section" EXACT [] xref: FMA:52810 is_a: BSPO:0000400 ! anatomical plane [Term] id: BSPO:0000026 name: antero-dorsal region namespace: spatial def: "Anatomical region that overlaps the anterior and dorsal regions of a body or body part." [BSPO:wd] synonym: "anterodorsal region " EXACT [] is_a: BSPO:0000027 ! antero-ventral region is_a: BSPO:0000030 ! postero-dorsal region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000055 ! anterior side intersection_of: overlaps BSPO:0000063 ! dorsal side created_by: Melissa Haendel creation_date: 2009-06-15T01:01:38Z [Term] id: BSPO:0000027 name: antero-ventral region namespace: spatial def: "Anatomical region that overlaps the anterior and ventral regions of a body or body part." [BSPO:wd] synonym: "anteroventral region " EXACT [] is_a: BSPO:0000035 ! postero-ventral region is_a: BSPO:0000071 ! anterior region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000055 ! anterior side intersection_of: overlaps BSPO:0000068 ! ventral side created_by: Melissa Haendel creation_date: 2009-06-15T01:04:59Z [Term] id: BSPO:0000028 name: postero-lateral region namespace: spatial def: "Anatomical region that overlaps the posterior and lateral regions of the body or body part." [BSPO:wd] synonym: "posterolateral region" EXACT [] is_a: BSPO:0000072 ! posterior region is_a: BSPO:0000082 ! lateral region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000056 ! posterior side intersection_of: overlaps BSPO:0000066 ! lateral side created_by: Melissa Haendel creation_date: 2009-06-15T01:06:01Z [Term] id: BSPO:0000029 name: antero-lateral region namespace: spatial def: "Anatomical region that overlaps the anterior and lateral regions of a body or body part." [BSPO:wd] synonym: "anterolateral region" EXACT [] is_a: BSPO:0000028 ! postero-lateral region is_a: BSPO:0000071 ! anterior region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000055 ! anterior side intersection_of: overlaps BSPO:0000066 ! lateral side created_by: Melissa Haendel creation_date: 2009-06-15T01:07:18Z [Term] id: BSPO:0000030 name: postero-dorsal region namespace: spatial def: "Anatomical region that overlaps the posterior and dorsal regions of the body or body part." [BSPO:wd] synonym: "posterodorsal region" EXACT [] is_a: BSPO:0000035 ! postero-ventral region is_a: BSPO:0000079 ! dorsal region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000056 ! posterior side intersection_of: overlaps BSPO:0000063 ! dorsal side created_by: Melissa Haendel creation_date: 2009-06-15T01:08:13Z [Term] id: BSPO:0000035 name: postero-ventral region namespace: spatial def: "Anatomical region that overlaps the posterior and ventral regions of a body or body part." [BSPO:wd] synonym: "posteroventral region" EXACT [] is_a: BSPO:0000072 ! posterior region is_a: BSPO:0000084 ! ventral region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000056 ! posterior side intersection_of: overlaps BSPO:0000068 ! ventral side created_by: Melissa Haendel creation_date: 2009-06-15T01:08:38Z [Term] id: BSPO:0000054 name: anatomical side namespace: spatial def: "An anatomical region bounded by a plane perpendicular to an axis through the middle." [BSPO:cjm] xref: FBql:00005841 is_a: BSPO:0000070 ! anatomical region [Term] id: BSPO:0000055 name: anterior side namespace: spatial def: "An anatomical region that is the entire part of an anatomical structure anterior to a transverse plane and bounded on one side by the same transverse plane." [BSPO:RW] synonym: "anterior" EXACT [] synonym: "rostral" EXACT [] xref: FBcv:0000053 xref: FBql:00005848 is_a: BSPO:0000054 ! anatomical side is_a: BSPO:0000072 ! posterior region relationship: anterior_to BSPO:0000056 ! posterior side relationship: opposite_to BSPO:0000056 ! posterior side relationship: starts_axis BSPO:0000013 ! anterior-posterior axis [Term] id: BSPO:0000056 name: posterior side namespace: spatial def: "An anatomical region that is the entire part of an anatomical structure posterior to a transverse plane and bounded on one side by the same transverse plane." [BSPO:RW, BSPO:wd] synonym: "caudal" NARROW vertebrate [] synonym: "posterior" EXACT [] xref: FBcv:0000065 xref: FBql:00005849 is_a: BSPO:0000054 ! anatomical side relationship: finishes_axis BSPO:0000013 ! anterior-posterior axis relationship: posterior_to BSPO:0000055 ! anterior side [Term] id: BSPO:0000057 name: apical side namespace: spatial def: "Anatomical side that is located on the apical end of an organism or structure." [BSPO:wd] synonym: "apical" EXACT [] xref: FBcv:0000054 xref: FBql:00005854 is_a: BSPO:0000054 ! anatomical side is_a: BSPO:0000074 ! basal region relationship: opposite_to BSPO:0000058 ! basal side relationship: starts_axis BSPO:0000014 ! apical-basal axis relative to substrate [Term] id: BSPO:0000058 name: basal side namespace: spatial def: "Anatomical side that is located on the basal end of an organism or structure." [BSPO:wd] comment: The part of the organism attached to a substrate. Axis of symmetry. synonym: "basal" EXACT [] xref: FBcv:0000055 xref: FBql:00005855 is_a: BSPO:0000054 ! anatomical side relationship: finishes_axis BSPO:0000014 ! apical-basal axis relative to substrate [Term] id: BSPO:0000063 name: dorsal side namespace: spatial def: "An anatomical region that is the entire part of an anatomical structure dorsal to a horizontal plane and bounded on one side by the same transverse plane." [BSPO:wd] synonym: "dorsal" EXACT [] xref: FBcv:0000059 xref: FBql:00005842 is_a: BSPO:0000054 ! anatomical side is_a: BSPO:0000084 ! ventral region relationship: dorsal_to BSPO:0000066 ! lateral side relationship: opposite_to BSPO:0000068 ! ventral side relationship: starts_axis BSPO:0000016 ! dorsal-ventral axis [Term] id: BSPO:0000066 name: lateral side namespace: spatial synonym: "lateral" EXACT [] xref: FBcv:0000063 xref: FBql:00005844 is_a: BSPO:0000054 ! anatomical side [Term] id: BSPO:0000068 name: ventral side namespace: spatial def: "An anatomical region that is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane." [BSPO:RW, BSPO:wd] synonym: "ventral" EXACT [] xref: FBcv:0000070 xref: FBql:00005843 is_a: BSPO:0000054 ! anatomical side relationship: finishes_axis BSPO:0000016 ! dorsal-ventral axis [Term] id: BSPO:0000070 name: anatomical region namespace: spatial def: "A 3D region in space without well-defined compartmental boundaries; for example, the dorsal region of an ectoderm." [BSPO:cjm] comment: to be merged into CARO xref: FBql:00005841 is_a: CARO:0000003 ! anatomical structure [Term] id: BSPO:0000071 name: anterior region namespace: spatial def: "Anatomical region anteriorly located on the body or body part." [BSPO:wd] xref: FBql:00005848 is_a: BSPO:0000072 ! posterior region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000055 ! anterior side relationship: overlaps BSPO:0000055 ! anterior side [Term] id: BSPO:0000072 name: posterior region namespace: spatial def: "Anatomical region posteriorly located on the body or body part." [BSPO:wd] xref: FBql:00005849 is_a: BSPO:0000070 ! anatomical region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000056 ! posterior side relationship: overlaps BSPO:0000056 ! posterior side [Term] id: BSPO:0000073 name: apical region namespace: spatial def: "Anatomical region located on the apical end on the body or body part." [BSPO:wd] xref: FBql:00005854 is_a: BSPO:0000074 ! basal region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000057 ! apical side relationship: overlaps BSPO:0000057 ! apical side [Term] id: BSPO:0000074 name: basal region namespace: spatial def: "Anatomical region located basally on the body or body part." [BSPO:wd] xref: FBql:00005855 is_a: BSPO:0000070 ! anatomical region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000058 ! basal side relationship: overlaps BSPO:0000058 ! basal side [Term] id: BSPO:0000079 name: dorsal region namespace: spatial def: "Anatomical region dorsally located on the body or body part." [BSPO:wd] xref: FBql:00005842 is_a: BSPO:0000084 ! ventral region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000063 ! dorsal side relationship: overlaps BSPO:0000063 ! dorsal side [Term] id: BSPO:0000080 name: dorso-lateral region namespace: spatial def: "Anatomical region that overlaps the dorsal and lateral regions of a body or body part." [BSPO:wd] synonym: "dorsolateral region" EXACT [] xref: FBql:00005845 is_a: BSPO:0000079 ! dorsal region is_a: BSPO:0000085 ! ventro-lateral region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000063 ! dorsal side intersection_of: overlaps BSPO:0000066 ! lateral side [Term] id: BSPO:0000082 name: lateral region namespace: spatial def: "Anatomical region laterally located on the body or body part." [BSPO:wd] xref: FBql:00005844 is_a: BSPO:0000070 ! anatomical region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000066 ! lateral side relationship: overlaps BSPO:0000066 ! lateral side [Term] id: BSPO:0000084 name: ventral region namespace: spatial def: "Anatomical region ventrally located on the body or body part." [BSPO:wd] xref: FBql:00005843 is_a: BSPO:0000070 ! anatomical region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000068 ! ventral side relationship: overlaps BSPO:0000068 ! ventral side [Term] id: BSPO:0000085 name: ventro-lateral region namespace: spatial def: "Anatomical region that overlaps the ventral and lateral regions of a body or body part." [BSPO:wd] comment: This is an example of a composition of two axis positions. synonym: "ventrolateral region" EXACT [] xref: FBql:00005846 is_a: BSPO:0000082 ! lateral region is_a: BSPO:0000084 ! ventral region intersection_of: BSPO:0000070 ! anatomical region intersection_of: overlaps BSPO:0000066 ! lateral side intersection_of: overlaps BSPO:0000068 ! ventral side [Term] id: BSPO:0000086 name: anatomical compartment namespace: spatial comment: to be merged into CARO xref: FBql:00005873 xref: FMA:9647 is_a: CARO:0000003 ! anatomical structure [Term] id: BSPO:0000090 name: posterior compartment namespace: spatial xref: FBcv:0000036 xref: FBql:00005875 is_a: BSPO:0000086 ! anatomical compartment [Term] id: BSPO:0000092 name: anatomical compartment boundary namespace: spatial comment: to be merged into CARO xref: FBql:00005881 is_a: CARO:0000010 ! anatomical boundary [Term] id: BSPO:0000094 name: dorsal/ventral compartment boundary namespace: spatial xref: FBcv:0000034 xref: FBql:00005879 is_a: BSPO:0000092 ! anatomical compartment boundary [Term] id: BSPO:0000196 name: medial-external axis namespace: spatial def: "An anatomical axis that extends from the center of the body outwards or externally." [BSPO:curators] comment: The medial-external axis could apply to a sphere-shaped body. synonym: "proximal-distal axis" RELATED [] is_a: BSPO:0000010 ! anatomical axis created_by: wasila.dahdul creation_date: 2013-07-02T11:21:42Z [Term] id: BSPO:0000198 name: oral-aboral axis namespace: spatial def: "An axis that extends from the oral opening to the furthest point in an organism that is directly opposite." [BSPO:PM] is_a: BSPO:0000010 ! anatomical axis created_by: wasila.dahdul creation_date: 2013-07-02T11:29:33Z [Term] id: BSPO:0000371 name: anterior surface namespace: spatial def: "Anatomical surface that is located on the anterior side of the body or body part." [BSPO:wd] xref: FBql:00005848 is_a: BSPO:0000005 ! anatomical surface intersection_of: BSPO:0000005 ! anatomical surface intersection_of: surface_of BSPO:0000055 ! anterior side relationship: surface_of BSPO:0000055 ! anterior side [Term] id: BSPO:0000372 name: posterior surface namespace: spatial def: "Anatomical surface that is located on the posterior side of the body or body part." [BSPO:wd] xref: FBql:00005849 is_a: BSPO:0000005 ! anatomical surface intersection_of: BSPO:0000005 ! anatomical surface intersection_of: surface_of BSPO:0000056 ! posterior side relationship: surface_of BSPO:0000056 ! posterior side [Term] id: BSPO:0000373 name: apical surface namespace: spatial def: "Anatomical surface that is located on the apical side of the body or body part." [BSPO:wd] xref: FBql:00005854 is_a: BSPO:0000005 ! anatomical surface intersection_of: BSPO:0000005 ! anatomical surface intersection_of: surface_of BSPO:0000057 ! apical side relationship: surface_of BSPO:0000057 ! apical side [Term] id: BSPO:0000374 name: basal surface namespace: spatial def: "Anatomical surface that is located on the basal side of the body or body part." [BSPO:wd] xref: FBql:00005855 is_a: BSPO:0000005 ! anatomical surface intersection_of: BSPO:0000005 ! anatomical surface intersection_of: surface_of BSPO:0000058 ! basal side relationship: surface_of BSPO:0000058 ! basal side [Term] id: BSPO:0000379 name: dorsal surface namespace: spatial def: "Anatomical surface that located on the dorsal side of the body or body part." [BSPO:wd] xref: FBql:00005842 is_a: BSPO:0000005 ! anatomical surface intersection_of: BSPO:0000005 ! anatomical surface intersection_of: surface_of BSPO:0000063 ! dorsal side relationship: surface_of BSPO:0000063 ! dorsal side [Term] id: BSPO:0000382 name: lateral surface namespace: spatial def: "Anatomical surface that located on the lateral side of the body or body part." [BSPO:wd] xref: FBql:00005844 is_a: BSPO:0000005 ! anatomical surface intersection_of: BSPO:0000005 ! anatomical surface intersection_of: surface_of BSPO:0000066 ! lateral side relationship: surface_of BSPO:0000066 ! lateral side [Term] id: BSPO:0000384 name: ventral surface namespace: spatial def: "Anatomical surface that is located on the ventral side of the body or body part." [BSPO:wd] xref: FBql:00005843 is_a: BSPO:0000005 ! anatomical surface intersection_of: BSPO:0000005 ! anatomical surface intersection_of: surface_of BSPO:0000068 ! ventral side relationship: surface_of BSPO:0000068 ! ventral side [Term] id: BSPO:0000400 name: anatomical plane namespace: spatial def: "A flat 2D plane intersecting an anatomical continuant, dividing it into two adjacent portions." [BSPO:cjm] comment: These anatomical sections are applicable to most bilaterally symmetrical animals, but bipedal animals such as humans have more complex usage of these terms. For example, in post-embryonic humans a coronal plane is vertical and a transverse plane is horizontal, but for embryos and quadrupeds a coronal plane is horizontal and a transverse plane is vertical. synonym: "anatomical cross-section" EXACT [] synonym: "anatomical section" EXACT [] synonym: "cross-section" RELATED [] synonym: "plane" EXACT [] synonym: "section" EXACT [] xref: FMA:242982 is_a: CARO:0000010 ! anatomical boundary [Term] id: BSPO:0000417 name: sagittal plane namespace: spatial def: "Anatomical plane that divides a bilateral body into left and right parts, not necessarily of even size." [BSPO:cjm, BSPO:DOS, BSPO:mah] synonym: "left/right plane" EXACT [] synonym: "median plane" EXACT [] synonym: "sagittal section" EXACT [] xref: FMA:11361 is_a: BSPO:0000010 ! anatomical axis is_a: BSPO:0000400 ! anatomical plane intersection_of: BSPO:0000400 ! anatomical plane intersection_of: orthogonal_to BSPO:0000017 ! left-right axis intersection_of: parallel_to BSPO:0000013 ! anterior-posterior axis intersection_of: parallel_to BSPO:0000016 ! dorsal-ventral axis relationship: orthogonal_to BSPO:0000017 ! left-right axis relationship: parallel_to BSPO:0000013 ! anterior-posterior axis relationship: parallel_to BSPO:0000016 ! dorsal-ventral axis [Term] id: BSPO:0001001 name: medial-lateral axis namespace: spatial def: "An axis that extends from the center of organism to one or other side." [BSPO:cjm] comment: Properly, the ML axis is a half axis; practically, its usage is less clumsy and less linguistically biased than "left-right". The terms may still be used relatively to describe locations along the LR axis. The gills are medial to the operculum, but lateral to the heart. synonym: "M-L axis" EXACT [] synonym: "medio-lateral axis" EXACT [] synonym: "mediolateral axis" EXACT [] synonym: "ML axis" EXACT [] synonym: "proximal-distal axis " RELATED [] xref: http://upload.wikimedia.org/wikipedia/commons/3/34/Anatomical_Directions_and_Axes.JPG is_a: BSPO:0000196 ! medial-external axis [Term] id: CARO:0000000 name: anatomical entity namespace: spatial def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH] is_a: CARO:0030000 ! biological entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CARO:0000003 name: anatomical structure name: connected anatomical structure namespace: spatial def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CC:DOS] is_a: CARO:0000006 ! material anatomical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CARO:0000006 name: material anatomical entity namespace: spatial def: "An anatomical entity that has mass." [CC:DOS] is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CARO:0000007 name: immaterial anatomical entity namespace: spatial def: "An anatomical entity that has no mass." [CC:DOS] is_a: BFO:0000141 ! immaterial entity is_a: CARO:0000000 ! anatomical entity [Term] id: CARO:0000008 name: anatomical line namespace: spatial def: "A one dimensional, immaterial anatomical entity." [CC:DOS] is_a: CARO:0000007 ! immaterial anatomical entity [Term] id: CARO:0000010 name: anatomical boundary namespace: spatial def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CC:DOS] is_a: CARO:0000007 ! immaterial anatomical entity [Term] id: CARO:0000014 name: cell part is_a: CARO:0000003 ! anatomical structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl property_value: IAO:0000589 "cell part (CARO)" xsd:string [Term] id: CARO:0001010 name: organism or virus or viroid is_a: BFO:0000040 ! material entity [Term] id: CARO:0010000 name: multicellular anatomical structure is_a: CARO:0000003 ! anatomical structure relationship: RO:0002207 CARO:0010000 ! directly develops from multicellular anatomical structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl [Term] id: CARO:0030000 name: biological entity is_a: BFO:0000004 ! independent continuant [Term] id: CL:0000000 name: cell is_a: CARO:0000003 ! anatomical structure relationship: has_part GO:0005634 {gci_filler="PATO:0001407", gci_relation="bearer_of"} ! nucleus relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="bearer_of"} ! nucleus relationship: RO:0002207 CL:0000000 ! directly develops from cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: CL:0000540 name: neuron is_a: CL:0000000 ! cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: ENVO:01000254 name: environmental system is_a: RO:0002577 ! system [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B." [GOC:mtg_cell_cycle, GOC:vw] synonym: "spindle elongation during mitosis" EXACT [] is_a: GO:0051231 ! spindle elongation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051231 ! spindle elongation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of GO:0007052 ! mitotic spindle organization [Term] id: GO:0000045 name: autophagosome assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0070925 ! organelle assembly is_a: GO:1905037 ! autophagosome organization relationship: has_part GO:0019778 ! Atg12 activating enzyme activity relationship: has_part GO:0019786 ! Atg8-specific protease activity relationship: has_part GO:0061651 ! Atg12 conjugating enzyme activity relationship: has_part GO:0061660 ! Atg12 ligase activity [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] subset: goslim_pombe synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0000080 name: mitotic G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G1 phase of mitotic cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.01.01 is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000084 name: mitotic S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S phase of mitotic cell cycle" EXACT [] synonym: "S-phase of mitotic cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.01.05 is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000085 name: mitotic G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G2 phase of mitotic cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.01.07 is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000087 name: mitotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of mitotic cell cycle" EXACT [] synonym: "M-phase of mitotic cell cycle" EXACT [] is_a: GO:0000279 ! M phase is_a: GO:0098763 ! mitotic cell cycle phase intersection_of: GO:0000279 ! M phase intersection_of: happens_during GO:0000278 ! mitotic cell cycle [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000122 name: negative regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0010553 alt_id: GO:0045816 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006366 ! transcription by RNA polymerase II relationship: negatively_regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process alt_id: GO:0043147 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah] synonym: "meiotic spindle organisation" EXACT [] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "meiotic spindle stabilization" RELATED [] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_drosophila subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Leptotene xref: Wikipedia:Meiosis#Leptotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Zygotene xref: Wikipedia:Zygotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Pachytene xref: Wikipedia:Pachytene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Diplotene xref: Wikipedia:Meiosis#Diplotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Diakinesis xref: Wikipedia:Meiosis#Diakinesis is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: MIPS_funcat:10.03.01 xref: MIPS_funcat:10.03.01.01 xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140014 ! mitotic nuclear division relationship: has_part GO:0140014 ! mitotic nuclear division [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] xref: MIPS_funcat:10.03.04 xref: MIPS_funcat:10.03.04.07 is_a: GO:0048285 ! organelle fission [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process intersection_of: GO:0016070 ! RNA metabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_manually_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0001523 name: retinoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732] synonym: "retinoid metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001539 name: cilium or flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "ciliary or bacterial-type flagellar motility" RELATED [] synonym: "ciliary/flagellar motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016049 ! cell growth relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: part_of GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001661 name: conditioned taste aversion namespace: biological_process def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] xref: Wikipedia:Conditioned_taste_aversion xref: Wikipedia:Taste_aversion is_a: GO:0007631 ! feeding behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0001675 name: acrosome assembly namespace: biological_process def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033363 ! secretory granule organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0001896 name: autolysis namespace: biological_process def: "A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation." [GOC:add, GOC:jh2, GOC:mtg_apoptosis, PMID:10974124, PMID:19286987, PMID:26811896] xref: Wikipedia:Autolysis is_a: GO:0012501 ! programmed cell death property_value: RO:0002161 NCBITaxon:33208 [Term] id: GO:0001906 name: cell killing namespace: biological_process def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0001907 name: killing by symbiont of host cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] is_a: GO:0051701 ! interaction with host is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006468 ! protein phosphorylation relationship: regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006468 ! protein phosphorylation relationship: negatively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006468 ! protein phosphorylation relationship: positively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [] is_a: GO:0048731 ! system development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0002246 name: wound healing involved in inflammatory response namespace: biological_process def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "healing during inflammatory response" RELATED [GOC:dph] synonym: "inflammatory response wound healing" RELATED [GOC:dph] is_a: GO:0042060 ! wound healing intersection_of: GO:0042060 ! wound healing intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0090594 ! inflammatory response to wounding [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "acquired immune response" EXACT [ISBN:068340007X] synonym: "immune memory response" EXACT [GOC:add] xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process intersection_of: GO:0001775 ! cell activation intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "macrophage activation during immune response" RELATED [GOC:tb] synonym: "macrophage polarization involved in immune response" EXACT [] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042116 ! macrophage activation intersection_of: GO:0042116 ! macrophage activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0046649 ! lymphocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002323 name: natural killer cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] synonym: "NK cell activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0030101 ! natural killer cell activation intersection_of: GO:0030101 ! natural killer cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0002437 name: inflammatory response to antigenic stimulus namespace: biological_process def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149] is_a: GO:0006954 ! inflammatory response is_a: GO:0006955 ! immune response [Term] id: GO:0002438 name: acute inflammatory response to antigenic stimulus namespace: biological_process def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002445 name: type II hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] xref: Wikipedia:Type_II_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development [Term] id: GO:0002524 name: hypersensitivity namespace: biological_process def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149] synonym: "hypersensitivity response" RELATED [ISBN:0781735149] xref: Wikipedia:Hypersensitivity is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002526 name: acute inflammatory response namespace: biological_process def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002673 name: regulation of acute inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002526 ! acute inflammatory response relationship: regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002674 name: negative regulation of acute inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "down regulation of acute inflammatory response" EXACT [] synonym: "down-regulation of acute inflammatory response" EXACT [] synonym: "downregulation of acute inflammatory response" EXACT [] synonym: "inhibition of acute inflammatory response" NARROW [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002526 ! acute inflammatory response relationship: negatively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002675 name: positive regulation of acute inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "activation of acute inflammatory response" NARROW [] synonym: "stimulation of acute inflammatory response" NARROW [] synonym: "up regulation of acute inflammatory response" EXACT [] synonym: "up-regulation of acute inflammatory response" EXACT [] synonym: "upregulation of acute inflammatory response" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002526 ! acute inflammatory response relationship: positively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002376 ! immune system process relationship: regulates GO:0002376 ! immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002376 ! immune system process relationship: negatively_regulates GO:0002376 ! immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002376 ! immune system process relationship: positively_regulates GO:0002376 ! immune system process [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045321 ! leukocyte activation relationship: regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045321 ! leukocyte activation relationship: negatively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045321 ! leukocyte activation relationship: positively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002252 ! immune effector process relationship: regulates GO:0002252 ! immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002252 ! immune effector process relationship: negatively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002252 ! immune effector process relationship: positively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002443 ! leukocyte mediated immunity relationship: regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002443 ! leukocyte mediated immunity relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002443 ! leukocyte mediated immunity relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002449 ! lymphocyte mediated immunity relationship: regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002449 ! lymphocyte mediated immunity relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002449 ! lymphocyte mediated immunity relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "regulation of B lymphocyte mediated immunity" EXACT [] synonym: "regulation of B-cell mediated immunity" EXACT [] synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019724 ! B cell mediated immunity relationship: regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002713 name: negative regulation of B cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "down regulation of B cell mediated immunity" EXACT [] synonym: "down-regulation of B cell mediated immunity" EXACT [] synonym: "downregulation of B cell mediated immunity" EXACT [] synonym: "inhibition of B cell mediated immunity" NARROW [] synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of B-cell mediated immunity" EXACT [] synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019724 ! B cell mediated immunity relationship: negatively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "activation of B cell mediated immunity" NARROW [] synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of B-cell mediated immunity" EXACT [] synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of B cell mediated immunity" NARROW [] synonym: "up regulation of B cell mediated immunity" EXACT [] synonym: "up-regulation of B cell mediated immunity" EXACT [] synonym: "upregulation of B cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019724 ! B cell mediated immunity relationship: positively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002790 ! peptide secretion relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002790 ! peptide secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002790 ! peptide secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002250 ! adaptive immune response relationship: regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002250 ! adaptive immune response relationship: negatively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002250 ! adaptive immune response relationship: positively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009607 ! response to biotic stimulus relationship: regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus relationship: negatively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus relationship: positively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002861 name: regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002862 name: negative regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002863 name: positive regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002864 name: regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002865 name: negative regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002866 name: positive regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002883 name: regulation of hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002524 ! hypersensitivity relationship: regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002884 name: negative regulation of hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "down regulation of hypersensitivity" EXACT [] synonym: "down-regulation of hypersensitivity" EXACT [] synonym: "downregulation of hypersensitivity" EXACT [] synonym: "inhibition of hypersensitivity" NARROW [] is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002524 ! hypersensitivity relationship: negatively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002885 name: positive regulation of hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "activation of hypersensitivity" NARROW [] synonym: "stimulation of hypersensitivity" NARROW [] synonym: "up regulation of hypersensitivity" EXACT [] synonym: "up-regulation of hypersensitivity" EXACT [] synonym: "upregulation of hypersensitivity" EXACT [] is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002524 ! hypersensitivity relationship: positively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016064 ! immunoglobulin mediated immune response relationship: regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002890 name: negative regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "activation of immunoglobulin mediated immune response" NARROW [] synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016064 ! immunoglobulin mediated immune response relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002892 name: regulation of type II hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002445 ! type II hypersensitivity relationship: regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002893 name: negative regulation of type II hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "down regulation of type II hypersensitivity" EXACT [] synonym: "down-regulation of type II hypersensitivity" EXACT [] synonym: "downregulation of type II hypersensitivity" EXACT [] synonym: "inhibition of type II hypersensitivity" NARROW [] is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002445 ! type II hypersensitivity relationship: negatively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002894 name: positive regulation of type II hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "activation of type II hypersensitivity" NARROW [] synonym: "stimulation of type II hypersensitivity" NARROW [] synonym: "up regulation of type II hypersensitivity" EXACT [] synonym: "up-regulation of type II hypersensitivity" EXACT [] synonym: "upregulation of type II hypersensitivity" EXACT [] is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002445 ! type II hypersensitivity relationship: positively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: part_of GO:0000003 ! reproduction [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] synonym: "excretory system process" EXACT [] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003341 name: cilium movement namespace: biological_process alt_id: GO:0036142 def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliary motility" RELATED [] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "flagellar motility" RELATED [] synonym: "flagellar movement" NARROW [GOC:bf] synonym: "flagellum movement" NARROW [] synonym: "microtubule-based flagellum movement" EXACT [] is_a: GO:0007018 ! microtubule-based movement property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: dph creation_date: 2009-11-24T09:56:26Z [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process alt_id: GO:1900172 def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "regulation of flagellum movement" RELATED [] synonym: "regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003341 ! cilium movement relationship: regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:12:00Z [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process alt_id: GO:1900174 def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "positive regulation of flagellum movement" RELATED [] synonym: "positive regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051272 ! positive regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003341 ! cilium movement relationship: positively_regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:16:10Z [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process alt_id: GO:1900173 def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "negative regulation of flagellum movement" RELATED [] synonym: "negative regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051271 ! negative regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003341 ! cilium movement relationship: negatively_regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:17:47Z [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] is_a: BFO:0000015 ! process property_value: IAO:0000589 "molecular process" xsd:string [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function alt_id: GO:0000496 def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "base pairing" NARROW [] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0003677 name: DNA binding namespace: molecular_function alt_id: GO:0043566 def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003707 name: steroid hormone receptor activity namespace: molecular_function def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: nuclear receptor activity ; GO:0004879' or nuclear receptor transcription coactivator activity ; GO:0030374'. is_a: GO:0038023 ! signaling receptor activity relationship: part_of GO:0043401 ! steroid hormone mediated signaling pathway [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0004888 name: transmembrane signaling receptor activity namespace: molecular_function alt_id: GO:0004926 alt_id: GO:0099600 def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor] comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling] synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah] xref: Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex" is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0004930 name: G protein-coupled receptor activity namespace: molecular_function alt_id: GO:0001622 alt_id: GO:0001623 alt_id: GO:0001624 alt_id: GO:0001625 alt_id: GO:0016526 def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] subset: goslim_chembl synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: Reactome:R-HSA-114552 "G12/13 activation by PAR" xref: Reactome:R-HSA-114558 "Gq activation by PAR" xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein" xref: Wikipedia:GPCR is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0005102 name: signaling receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_plant synonym: "receptor binding" BROAD [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "carrier" RELATED [] xref: EC:7 xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion" xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005310 name: dicarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005312 alt_id: GO:0015365 def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] synonym: "dicarboxylate carrier" NARROW [] synonym: "dicarboxylic acid permease activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate" xref: Reactome:R-HSA-372843 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0005342 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage," [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:1903825 ! organic acid transmembrane transport [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: MIPS_funcat:16.01 xref: MIPS_funcat:18.01.07 xref: Reactome:R-HSA-170835 "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3" xref: Reactome:R-HSA-170846 "TGFBR2 recruits TGFBR1" is_a: GO:0005488 ! binding [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "extracellular" EXACT [] xref: MIPS_funcat:70.27 xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, ISBN:0198547684, PMID:15134259, Wikipedia:Microbial_cyst] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure property_value: RO:0002161 NCBITaxon:33208 [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005623 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) is_a: GO:0005575 ! cellular_component property_value: IAO:0000589 "cell and encapsulating structures" xsd:string [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: MIPS_funcat:70.10 xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044464 ! obsolete cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005758 name: mitochondrial intermembrane space namespace: cellular_component alt_id: GO:0031971 def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] synonym: "mitochondrial envelope lumen" EXACT [] synonym: "mitochondrial membrane lumen" RELATED [] xref: NIF_Subcellular:sao118944228 is_a: GO:0031970 ! organelle envelope lumen relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component alt_id: GO:0031980 def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] synonym: "mitochondrial lumen" EXACT [] synonym: "mitochondrial stroma" NARROW [] xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005788 name: endoplasmic reticulum lumen namespace: cellular_component alt_id: GO:0016022 def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] synonym: "cisternal lumen" EXACT [] synonym: "endoplasmic reticulum cisterna" EXACT [] synonym: "ER cisterna" EXACT [] synonym: "ER lumen" EXACT [] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005790 name: smooth endoplasmic reticulum namespace: cellular_component def: "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] synonym: "SER" EXACT [] synonym: "smooth ER" EXACT [] xref: NIF_Subcellular:sao710427438 xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005791 name: rough endoplasmic reticulum namespace: cellular_component def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] synonym: "RER" EXACT [] synonym: "rough ER" EXACT [] xref: NIF_Subcellular:sao1881364067 xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005801 name: cis-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] comment: The CGN is not considered part of the Golgi apparatus but is a separate organelle. synonym: "cis face" BROAD [NIF_Subcellular:sao632188024] synonym: "cis Golgi network" EXACT [] synonym: "forming face" RELATED [] synonym: "Golgi cis face" RELATED [] synonym: "Golgi cis-face" RELATED [] xref: NIF_Subcellular:sao632188024 is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0005811 name: lipid droplet namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid particle" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005819 name: spindle namespace: cellular_component def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] xref: Wikipedia:Spindle_apparatus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr subset: goslim_aspergillus subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005844 name: polysome namespace: cellular_component def: "A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871] subset: goslim_pir synonym: "polyribosome" EXACT [NIF_Subcellular:sao1038025871] xref: NIF_Subcellular:sao1038025871 xref: Wikipedia:Polysome is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005929 name: cilium namespace: cellular_component alt_id: GO:0072372 def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043226 ! organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: has_part GO:0030990 ! intraciliary transport particle property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0071944 ! cell periphery relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate metabolic process" NARROW [] synonym: "single-organism carbohydrate metabolic process" RELATED [] xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: janelomax creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir synonym: "organic acid metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005975 ! carbohydrate metabolic process relationship: regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006140 name: regulation of nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "regulation of nucleotide metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009117 ! nucleotide metabolic process relationship: regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0006163 name: purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0006164 name: purine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleotide anabolism" EXACT [] synonym: "purine nucleotide biosynthesis" EXACT [] synonym: "purine nucleotide formation" EXACT [] synonym: "purine nucleotide synthesis" EXACT [] xref: MetaCyc:DENOVOPURINE2-PWY is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0006304 name: DNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0006305 name: DNA alkylation namespace: biological_process def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970] is_a: GO:0006304 ! DNA modification [Term] id: GO:0006306 name: DNA methylation namespace: biological_process def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732] xref: Wikipedia:DNA_methylation is_a: GO:0006305 ! DNA alkylation is_a: GO:0043414 ! macromolecule methylation is_a: GO:0044728 ! DNA methylation or demethylation property_value: RO:0002161 NCBITaxon:4895 property_value: RO:0002161 NCBITaxon:4930 [Term] id: GO:0006323 name: DNA packaging namespace: biological_process def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "DNA condensation" EXACT [] synonym: "DNA organisation" EXACT [] synonym: "DNA organization" EXACT [] is_a: GO:0071103 ! DNA conformation change relationship: has_part GO:0008301 ! DNA binding, bending [Term] id: GO:0006351 name: transcription, DNA-templated namespace: biological_process alt_id: GO:0006350 alt_id: GO:0061018 alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] subset: goslim_aspergillus subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cellular transcription" BROAD [] synonym: "cellular transcription, DNA-dependent" EXACT [] synonym: "DNA-dependent transcription" EXACT [] synonym: "transcription" BROAD [] synonym: "transcription regulator activity" RELATED [] synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH] xref: Wikipedia:Transcription_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0097659 ! nucleic acid-templated transcription relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006355 name: regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0032583 alt_id: GO:0045449 alt_id: GO:0061019 def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "regulation of gene-specific transcription" RELATED [] synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcriptional control" BROAD [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903506 ! regulation of nucleic acid-templated transcription is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006351 ! transcription, DNA-templated relationship: regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006357 name: regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0006358 alt_id: GO:0010551 def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "global transcription regulation from Pol II promoter" RELATED [] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "regulation of global transcription from Pol II promoter" RELATED [] synonym: "regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II relationship: regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006366 name: transcription by RNA polymerase II namespace: biological_process alt_id: GO:0032568 alt_id: GO:0032569 def: "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] subset: goslim_yeast synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "general transcription from RNA polymerase II promoter" RELATED [] synonym: "RNA polymerase II transcription factor activity" RELATED [] synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah] synonym: "transcription from Pol II promoter" EXACT [] synonym: "transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14854 xsd:anyURI [Term] id: GO:0006390 name: mitochondrial transcription namespace: biological_process def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] synonym: "transcription from mitochondrial promoter" EXACT [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006351 ! transcription, DNA-templated intersection_of: GO:0006351 ! transcription, DNA-templated intersection_of: occurs_in GO:0005739 ! mitochondrion intersection_of: part_of GO:0140053 ! mitochondrial gene expression relationship: part_of GO:0140053 ! mitochondrial gene expression property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14854 xsd:anyURI [Term] id: GO:0006464 name: cellular protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "process resulting in protein modification" RELATED [] synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] synonym: "protein tagging activity" RELATED [] is_a: GO:0036211 ! protein modification process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: goslim_yeast synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0006486 name: protein glycosylation namespace: biological_process alt_id: GO:0065006 def: "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] subset: goslim_pombe subset: goslim_yeast synonym: "protein amino acid glycosylation" EXACT [GOC:bf] synonym: "protein-carbohydrate complex assembly" RELATED [] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0043413 ! macromolecule glycosylation relationship: part_of GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006487 name: protein N-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] synonym: "N-glycan biosynthesis" RELATED [] synonym: "N-glycan metabolism" RELATED [] synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0151 xref: RESID:AA0156 xref: RESID:AA0327 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006575 name: cellular modified amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] synonym: "modified amino acid metabolic process" EXACT [GOC:mah] synonym: "modified amino acid metabolism" EXACT [GOC:mah] is_a: GO:0044237 ! cellular metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process alt_id: GO:0016096 def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732] synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006732 name: coenzyme metabolic process namespace: biological_process alt_id: GO:0006752 def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "coenzyme metabolism" EXACT [] synonym: "group transfer coenzyme metabolic process" NARROW [] synonym: "group transfer coenzyme metabolism" NARROW [] is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006753 name: nucleoside phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] synonym: "nucleoside phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0006754 name: ATP biosynthetic process namespace: biological_process alt_id: GO:0006758 alt_id: GO:0006759 def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] synonym: "ATP anabolism" EXACT [] synonym: "ATP biosynthesis" EXACT [] synonym: "ATP formation" EXACT [] synonym: "ATP regeneration" NARROW [] synonym: "ATP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006760 name: folic acid-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah] synonym: "folate and derivative metabolic process" EXACT [] synonym: "folate and derivative metabolism" EXACT [] synonym: "folate-containing compound metabolic process" EXACT [] synonym: "folate-containing compound metabolism" EXACT [] synonym: "folic acid and derivative metabolic process" EXACT [] synonym: "folic acid and derivative metabolism" EXACT [] synonym: "folic acid-containing compound metabolism" EXACT [] synonym: "vitamin B9 and derivative metabolic process" EXACT [] synonym: "vitamin B9 and derivative metabolism" EXACT [] synonym: "vitamin M and derivative metabolic process" EXACT [] synonym: "vitamin M and derivative metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "vitamin metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006767 name: water-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl] synonym: "water-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006768 name: biotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732] synonym: "biotin metabolism" EXACT [] synonym: "vitamin B7 metabolic process" EXACT [] synonym: "vitamin B7 metabolism" EXACT [] synonym: "vitamin H metabolic process" EXACT [] synonym: "vitamin H metabolism" EXACT [] xref: Wikipedia:Biotin is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006772 name: thiamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732] synonym: "thiamin metabolic process" EXACT [] synonym: "thiamin metabolism" EXACT [] synonym: "thiamine metabolism" EXACT [] synonym: "vitamin B1 metabolic process" EXACT [] synonym: "vitamin B1 metabolism" EXACT [] xref: Wikipedia:Thiamine is_a: GO:0042723 ! thiamine-containing compound metabolic process [Term] id: GO:0006775 name: fat-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] synonym: "fat-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006776 name: vitamin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "vitamin A metabolism" EXACT [] is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0006775 ! fat-soluble vitamin metabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Wikipedia:Sulfur_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] xref: MIPS_funcat:01.04 is_a: GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "single-organism transport" RELATED [] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] is_a: GO:0051234 ! establishment of localization created_by: janelomax creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006811 name: ion transport namespace: biological_process def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast is_a: GO:0006810 ! transport [Term] id: GO:0006820 name: anion transport namespace: biological_process alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006811 ! ion transport [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process alt_id: GO:0006841 def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006855 name: drug transmembrane transport namespace: biological_process def: "The process in which a drug is transported across a membrane." [GOC:ai, GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "drug membrane transport" EXACT [] synonym: "multidrug transport" RELATED [] is_a: GO:0015893 ! drug transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005576 ! extracellular region relationship: occurs_in GO:0005576 ! extracellular region [Term] id: GO:0006873 name: cellular ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of ions at the level of a cell." [GOC:mah] subset: goslim_yeast is_a: GO:0050801 ! ion homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0006874 name: cellular calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] synonym: "regulation of calcium ion concentration" BROAD [] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055074 ! calcium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006875 name: cellular metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cellular heavy metal ion homeostasis" NARROW [] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0006900 name: vesicle budding from membrane namespace: biological_process alt_id: GO:0006902 alt_id: GO:1902591 def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "single organism membrane budding" RELATED [GOC:TermGenie] synonym: "single-organism membrane budding" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: part_of GO:0016192 ! vesicle-mediated transport created_by: jl creation_date: 2013-12-19T15:26:17Z [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0051650 ! establishment of vesicle localization [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Wikipedia:Autophagy_(cellular) is_a: GO:0044248 ! cellular catabolic process is_a: GO:0061919 ! process utilizing autophagic mechanism [Term] id: GO:0006915 name: apoptotic process namespace: biological_process alt_id: GO:0006917 alt_id: GO:0008632 def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] subset: goslim_pombe synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "caspase-dependent programmed cell death" RELATED [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] synonym: "cellular component disassembly involved in apoptosis" NARROW [] synonym: "cellular component disassembly involved in apoptotic process" BROAD [] synonym: "disassembly of cell structures" BROAD [] is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: part_of GO:0097194 ! execution phase of apoptosis relationship: part_of GO:0097194 ! execution phase of apoptosis [Term] id: GO:0006928 name: movement of cell or subcellular component namespace: biological_process def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] comment: Note that in GO cellular components include whole cells (cell is_a cellular component). subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cell movement" RELATED [] synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] synonym: "cellular component movement" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response namespace: biological_process alt_id: GO:0002217 alt_id: GO:0042829 def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006954 name: inflammatory response namespace: biological_process def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] synonym: "inflammation" BROAD [] xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006968 name: cellular defense response namespace: biological_process alt_id: GO:0002818 alt_id: GO:0016066 alt_id: GO:0016067 def: "A defense response that is mediated by cells." [GOC:ebc] synonym: "cellular defence response" EXACT [] synonym: "intracellular defence response" NARROW [] synonym: "intracellular defense response" NARROW [] is_a: GO:0006952 ! defense response property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18111 xsd:anyURI [Term] id: GO:0006970 name: response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] subset: goslim_yeast synonym: "osmotic response" EXACT [] synonym: "osmotic stress response" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0006972 name: hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009] synonym: "HOG response" EXACT [] synonym: "hypertonic response" EXACT [] synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006974 name: cellular response to DNA damage stimulus namespace: biological_process alt_id: GO:0034984 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] subset: goslim_yeast synonym: "cellular DNA damage response" EXACT [] synonym: "DNA damage response" EXACT [] synonym: "response to DNA damage stimulus" BROAD [] synonym: "response to genotoxic stress" EXACT [] is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0006996 name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: jl creation_date: 2013-12-19T15:25:51Z [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [] synonym: "nuclear organization" EXACT [] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007006 name: mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "mitochondrial membrane organisation" EXACT [] synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007036 name: vacuolar calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "cell-division cycle" EXACT [] xref: MIPS_funcat:10 xref: MIPS_funcat:10.03 xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007051 name: spindle organization namespace: biological_process alt_id: GO:0043146 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] synonym: "spindle organisation" EXACT [] synonym: "spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle stabilization" RELATED [] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0022402 ! cell cycle process [Term] id: GO:0007052 name: mitotic spindle organization namespace: biological_process alt_id: GO:0000071 alt_id: GO:0030472 alt_id: GO:0043148 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] comment: In fission yeast most mitotic spindle organization occurs in the nucleus. synonym: "mitotic spindle organisation" EXACT [] synonym: "mitotic spindle organisation in nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "mitotic spindle organization and biogenesis in cell nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis in nucleus" NARROW [] synonym: "mitotic spindle organization in nucleus" NARROW [] synonym: "mitotic spindle stabilization" RELATED [] synonym: "spindle organization and biogenesis during mitosis" EXACT [] synonym: "spindle organization and biogenesis in nucleus during mitosis" NARROW [] is_a: GO:0007051 ! spindle organization is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/15341 xsd:anyURI [Term] id: GO:0007053 name: spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0090306 ! spindle assembly involved in meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007140 ! male meiotic nuclear division relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007055 name: spindle assembly involved in male meiosis II namespace: biological_process def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis II spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007142 ! male meiosis II relationship: part_of GO:0007142 ! male meiosis II [Term] id: GO:0007056 name: spindle assembly involved in female meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiotic spindle assembly" RELATED [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0090306 ! spindle assembly involved in meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007143 ! female meiotic nuclear division relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0007058 name: spindle assembly involved in female meiosis II namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis II spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007147 ! female meiosis II relationship: part_of GO:0007147 ! female meiosis II [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0009987 ! cellular process [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] is_a: GO:0030261 ! chromosome condensation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140014 ! mitotic nuclear division relationship: regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0007128 name: meiotic prophase I namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007132 name: meiotic metaphase I namespace: biological_process def: "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007133 name: meiotic anaphase I namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] synonym: "meiosis II nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0061983 ! meiosis II cell cycle process is_a: GO:0140013 ! meiotic nuclear division [Term] id: GO:0007136 name: meiotic prophase II namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007137 name: meiotic metaphase II namespace: biological_process def: "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007138 name: meiotic anaphase II namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007139 name: meiotic telophase II namespace: biological_process def: "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007140 name: male meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw] synonym: "male meiosis" RELATED [] synonym: "male nuclear division" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0048232 ! male gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0048232 ! male gamete generation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007142 name: male meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah] synonym: "male meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007140 ! male meiotic nuclear division intersection_of: GO:0007135 ! meiosis II intersection_of: part_of GO:0048232 ! male gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007143 name: female meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. synonym: "female meiosis" BROAD [] synonym: "female meiotic division" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0007292 ! female gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0007292 ! female gamete generation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0007147 name: female meiosis II namespace: biological_process def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] synonym: "female meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007143 ! female meiotic nuclear division intersection_of: GO:0007135 ! meiosis II intersection_of: part_of GO:0007292 ! female gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0009987 ! cellular process is_a: GO:0022610 ! biological adhesion created_by: davidos creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007155 ! cell adhesion relationship: negatively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: MIPS_funcat:30 xref: Wikipedia:Signal_transduction is_a: GO:0009987 ! cellular process is_a: GO:0050794 ! regulation of cellular process relationship: part_of GO:0007154 ! cell communication relationship: part_of GO:0023052 ! signaling relationship: part_of GO:0051716 ! cellular response to stimulus [Term] id: GO:0007186 name: G protein-coupled receptor signaling pathway namespace: biological_process alt_id: GO:0038042 def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] subset: goslim_drosophila synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW [] synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah] synonym: "G protein coupled receptor protein signaling pathway" EXACT [] synonym: "G protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein coupled receptor protein signal transduction" EXACT [] synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf] synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf] synonym: "G-protein coupled receptor signalling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "GPCR signaling pathway" EXACT [] synonym: "GPCR signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_chembl subset: goslim_plant xref: MIPS_funcat:41 is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0007276 name: gamete generation namespace: biological_process alt_id: GO:0009552 def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0019953 ! sexual reproduction property_value: RO:0002161 NCBITaxon_Union:0000023 [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007283 name: spermatogenesis namespace: biological_process def: "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] synonym: "generation of spermatozoa" EXACT systematic_synonym [] xref: Wikipedia:Spermatogenesis is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007286 name: spermatid development namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] synonym: "spermatid cell development" EXACT [] synonym: "spermiogenesis" EXACT [] xref: Wikipedia:Spermiogenesis is_a: GO:0007281 ! germ cell development relationship: part_of GO:0048515 ! spermatid differentiation [Term] id: GO:0007288 name: sperm axoneme assembly namespace: biological_process def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0035082 ! axoneme assembly relationship: part_of GO:0007286 ! spermatid development relationship: part_of GO:0030317 ! flagellated sperm motility [Term] id: GO:0007289 name: spermatid nucleus differentiation namespace: biological_process def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. synonym: "spermatid nuclear differentiation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] is_a: GO:0007276 ! gamete generation [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" RELATED [] synonym: "zygote formation" RELATED [] xref: MIPS_funcat:41.05.01 is_a: GO:0009566 ! fertilization property_value: RO:0002161 NCBITaxon:58024 [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000278 ! mitotic cell cycle relationship: regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] subset: goslim_drosophila synonym: "pan-neural process" RELATED [] is_a: GO:0048731 ! system development [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0060322 ! head development [Term] id: GO:0007568 name: aging namespace: biological_process alt_id: GO:0016280 def: "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] subset: goslim_chembl subset: goslim_generic synonym: "ageing" EXACT [] xref: Wikipedia:Aging is_a: GO:0032502 ! developmental process [Term] id: GO:0007584 name: response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] synonym: "nutritional response pathway" NARROW [] synonym: "response to nutrients" EXACT [] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical [Term] id: GO:0007588 name: excretion namespace: biological_process def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] subset: goslim_pir xref: Wikipedia:Excretion is_a: GO:0003008 ! system process [Term] id: GO:0007596 name: blood coagulation namespace: biological_process def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732] synonym: "blood clotting" EXACT [] xref: Wikipedia:Coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0007599 name: hemostasis namespace: biological_process def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732] xref: Wikipedia:Hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] subset: goslim_drosophila xref: Wikipedia:Perception is_a: GO:0050877 ! nervous system process [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007602 name: phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] synonym: "opsin" RELATED [] synonym: "phototransduction, visible light, light adaptation" NARROW [] synonym: "phototrophin mediated phototransduction" NARROW [] xref: Wikipedia:Visual_phototransduction is_a: GO:0007165 ! signal transduction is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0007603 name: phototransduction, visible light namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "visual cascade" EXACT [PMID:1962207, PMID:9822721] synonym: "visual transduction" EXACT [PMID:10611962] is_a: GO:0007602 ! phototransduction is_a: GO:0009584 ! detection of visible light [Term] id: GO:0007604 name: phototransduction, UV namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732] synonym: "phototransduction, ultraviolet light" EXACT [] synonym: "phototransduction, ultraviolet radiation" EXACT [] synonym: "phototransduction, UV light" EXACT [] synonym: "phototransduction, UV radiation" EXACT [] synonym: "UV-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction is_a: GO:0009589 ! detection of UV is_a: GO:0034644 ! cellular response to UV [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007608 name: sensory perception of smell namespace: biological_process def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai] synonym: "olfaction" EXACT [] synonym: "scent perception" EXACT [] synonym: "sense of smell" EXACT [] synonym: "smell perception" EXACT [] xref: Wikipedia:Olfaction is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0007610 name: behavior namespace: biological_process alt_id: GO:0023032 alt_id: GO:0044708 alt_id: GO:0044709 def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior is_a: GO:0050896 ! response to stimulus disjoint_from: GO:0032502 ! developmental process created_by: janelomax creation_date: 2012-09-20T14:06:08Z [Term] id: GO:0007611 name: learning or memory namespace: biological_process def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] is_a: GO:0007610 ! behavior is_a: GO:0050890 ! cognition [Term] id: GO:0007612 name: learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] xref: Wikipedia:Learning is_a: GO:0007611 ! learning or memory [Term] id: GO:0007613 name: memory namespace: biological_process def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, ISBN:0582227089] xref: Wikipedia:Memory is_a: GO:0007611 ! learning or memory [Term] id: GO:0007614 name: short-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Short-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007616 name: long-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Long-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007617 name: mating behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior intersection_of: GO:0007610 ! behavior intersection_of: part_of GO:0007618 ! mating relationship: part_of GO:0007618 ! mating [Term] id: GO:0007618 name: mating namespace: biological_process def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] is_a: GO:0044703 ! multi-organism reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007620 name: copulation namespace: biological_process def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] is_a: GO:0007618 ! mating [Term] id: GO:0007622 name: rhythmic behavior namespace: biological_process def: "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] synonym: "rhythmic behavioral response to stimulus" EXACT [] synonym: "rhythmic behaviour" EXACT [] synonym: "rhythmic behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007623 name: circadian rhythm namespace: biological_process alt_id: GO:0050895 def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] subset: goslim_drosophila subset: goslim_plant synonym: "circadian process" EXACT [] synonym: "circadian response" RELATED [] synonym: "response to circadian rhythm" RELATED [] xref: Wikipedia:Circadian_rhythm is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] subset: goslim_drosophila synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007631 name: feeding behavior namespace: biological_process alt_id: GO:0044366 alt_id: GO:0044367 alt_id: GO:0044368 alt_id: GO:0044369 alt_id: GO:0044370 alt_id: GO:0044371 alt_id: GO:0044372 def: "Behavior associated with the intake of food." [GOC:mah] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "behavioral response to food" EXACT [] synonym: "behavioural response to food" EXACT [] synonym: "eating" NARROW [] synonym: "feeding behaviour" EXACT [] synonym: "feeding from phloem of other organism" NARROW [] synonym: "feeding from plant phloem" NARROW [] synonym: "feeding from tissue of other organism" NARROW [] synonym: "feeding from vascular tissue of another organism" NARROW [] synonym: "feeding from xylem of other organism" NARROW [] synonym: "feeding on blood of other organism" NARROW [] synonym: "feeding on or from other organism" NARROW [] synonym: "feeding on plant sap" NARROW [] synonym: "hematophagy" NARROW [] synonym: "injection of substance into other organism during feeding on blood of other organism" NARROW [] synonym: "taking of blood meal" NARROW [] xref: Wikipedia:List_of_feeding_behaviours is_a: GO:0007610 ! behavior property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18547 xsd:anyURI created_by: janelomax creation_date: 2011-10-27T03:53:33Z [Term] id: GO:0007632 name: visual behavior namespace: biological_process def: "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] synonym: "behavioral response to visual stimulus" EXACT [] synonym: "behavioural response to visual stimulus" EXACT [] synonym: "visual behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009416 ! response to light stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007635 name: chemosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] synonym: "behavioral response to chemical stimulus" EXACT [] synonym: "behavioural response to chemical stimulus" EXACT [] synonym: "chemosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0008104 name: protein localization namespace: biological_process alt_id: GO:0008105 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process is_a: BFO:0000015 ! process created_by: janelomax creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] synonym: "multicellular organism metabolic process" NARROW [] synonym: "single-organism metabolic process" RELATED [] xref: MIPS_funcat:01 xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4 xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: Reactome:R-HSA-3000243 "Unknown protease degrades GIF:Cbl to release Cbl" xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" xref: Reactome:R-HSA-5655483 "USP1 autocleavage" xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: Reactome:R-HSA-5693319 "CTRC hydrolyses PRSS1" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006508 ! proteolysis [Term] id: GO:0008234 name: cysteine-type peptidase activity namespace: molecular_function alt_id: GO:0004220 def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] synonym: "cysteine protease activity" NARROW [] synonym: "thiol protease activity" NARROW [] xref: Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)" xref: Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin" xref: Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008277 name: regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of GPCR protein signaling pathway" EXACT [] synonym: "regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007186 ! G protein-coupled receptor signaling pathway relationship: regulates GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0009987 ! cellular process property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008283 ! cell population proliferation relationship: positively_regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008283 ! cell population proliferation relationship: negatively_regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0008301 name: DNA binding, bending namespace: molecular_function def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] synonym: "DNA bending activity" EXACT [] synonym: "DNA bending involving DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0008306 name: associative learning namespace: biological_process def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] synonym: "classical conditioning" EXACT [] synonym: "conditional learning" EXACT [] synonym: "conditional response" EXACT [] synonym: "Pavlovian conditioning" EXACT [] xref: Wikipedia:Learning#Associative_learning is_a: GO:0007612 ! learning [Term] id: GO:0008355 name: olfactory learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] is_a: GO:0008306 ! associative learning is_a: GO:0042048 ! olfactory behavior [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008509 name: anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "anion transporter activity" EXACT [] xref: Reactome:R-HSA-166214 "FA anion flip-flops to the opposite surface" is_a: GO:0015075 ! ion transmembrane transporter activity relationship: part_of GO:0098656 ! anion transmembrane transport [Term] id: GO:0008514 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" is_a: GO:0008509 ! anion transmembrane transporter activity relationship: part_of GO:0015711 ! organic anion transport [Term] id: GO:0008517 name: folic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transmembrane transporter activity" EXACT [] synonym: "folate transporter activity" EXACT [] synonym: "folic acid transporter activity" RELATED [] synonym: "vitamin B9 transporter activity" EXACT [] synonym: "vitamin M transporter activity" EXACT [] xref: Reactome:R-HSA-200646 "Cytosolic folate export across the plasma membrane" xref: Reactome:R-HSA-200652 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane" xref: Reactome:R-HSA-200680 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane" xref: Reactome:R-HSA-200720 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane" xref: Reactome:R-HSA-200729 "Extracellular folate import across the plasma membrane" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015884 ! folic acid transport [Term] id: GO:0008542 name: visual learning namespace: biological_process def: "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] synonym: "spatial learning" RELATED [] is_a: GO:0007632 ! visual behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0008641 name: ubiquitin-like modifier activating enzyme activity namespace: molecular_function alt_id: GO:0008642 def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "small protein activating enzyme activity" NARROW [] is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14208 xsd:anyURI [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] synonym: "multicellular organismal catabolic process" NARROW [] synonym: "single-organism catabolic process" RELATED [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: goslim_drosophila synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009116 name: nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] subset: goslim_pir synonym: "nucleoside metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0009117 name: nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] subset: goslim_pir synonym: "nucleotide metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009118 name: regulation of nucleoside metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] synonym: "regulation of nucleoside metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009116 ! nucleoside metabolic process relationship: regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009119 name: ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] synonym: "ribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009123 name: nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009124 name: nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate anabolism" EXACT [] synonym: "nucleoside monophosphate biosynthesis" EXACT [] synonym: "nucleoside monophosphate formation" EXACT [] synonym: "nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009126 name: purine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009127 name: purine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate anabolism" EXACT [] synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] synonym: "purine nucleoside monophosphate formation" EXACT [] synonym: "purine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009141 name: nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009142 name: nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate anabolism" EXACT [] synonym: "nucleoside triphosphate biosynthesis" EXACT [] synonym: "nucleoside triphosphate formation" EXACT [] synonym: "nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009144 name: purine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009145 name: purine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate anabolism" EXACT [] synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] synonym: "purine nucleoside triphosphate formation" EXACT [] synonym: "purine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009150 name: purine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009152 name: purine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide anabolism" EXACT [] synonym: "purine ribonucleotide biosynthesis" EXACT [] synonym: "purine ribonucleotide formation" EXACT [] synonym: "purine ribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009156 name: ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate anabolism" EXACT [] synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "ribonucleoside monophosphate formation" EXACT [] synonym: "ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009161 name: ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009163 name: nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "nucleoside anabolism" EXACT [] synonym: "nucleoside biosynthesis" EXACT [] synonym: "nucleoside formation" EXACT [] synonym: "nucleoside synthesis" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034404 ! nucleobase-containing small molecule biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0009165 name: nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] synonym: "nucleotide anabolism" EXACT [] synonym: "nucleotide biosynthesis" EXACT [] synonym: "nucleotide formation" EXACT [] synonym: "nucleotide synthesis" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009167 name: purine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009168 name: purine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside monophosphate formation" EXACT [] synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009199 name: ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009201 name: ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate anabolism" EXACT [] synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "ribonucleoside triphosphate formation" EXACT [] synonym: "ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009205 name: purine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009206 name: purine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside triphosphate formation" EXACT [] synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009235 name: cobalamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] synonym: "cobalamin metabolism" EXACT [] synonym: "vitamin B12 metabolic process" EXACT [] synonym: "vitamin B12 metabolism" EXACT [] synonym: "vitamin B12 reduction" NARROW [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009259 name: ribonucleotide metabolic process namespace: biological_process alt_id: GO:0009121 def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019693 ! ribose phosphate metabolic process [Term] id: GO:0009260 name: ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide anabolism" EXACT [] synonym: "ribonucleotide biosynthesis" EXACT [] synonym: "ribonucleotide formation" EXACT [] synonym: "ribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:0046390 ! ribose phosphate biosynthetic process [Term] id: GO:0009266 name: response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] synonym: "response to thermal stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009267 name: cellular response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0033554 ! cellular response to stress is_a: GO:0042594 ! response to starvation [Term] id: GO:0009268 name: response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:jl, Wikipedia:PH] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009277 name: fungal-type cell wall namespace: cellular_component def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] synonym: "beta-glucan-containing cell wall" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] synonym: "chitin-containing cell wall" RELATED [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009279 name: cell outer membrane namespace: cellular_component def: "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:md, GOC:mtg_sensu, ISBN:0135712254] comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886. synonym: "outer membrane of cell" EXACT [] is_a: GO:0019867 ! outer membrane intersection_of: GO:0019867 ! outer membrane intersection_of: part_of GO:0030313 ! cell envelope relationship: part_of GO:0030312 ! external encapsulating structure relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] xref: Wikipedia:Nucleoid is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell." [GOC:ai] subset: goslim_drosophila synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0002790 ! peptide secretion is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell is_a: GO:0035592 ! establishment of protein localization to extracellular region [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009372 name: quorum sensing namespace: biological_process alt_id: GO:0010699 alt_id: GO:0060247 def: "The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms." [GOC:krc, GOC:mlg, PMID:10607620, PMID:15716452, PMID:16497924, PMID:16630813, PMID:8288518] subset: goslim_metagenomics subset: goslim_pir synonym: "cell-cell signaling involved in quorum sensing" RELATED [] synonym: "detection of cell density by secreted molecule" RELATED [] synonym: "quorum sensing system" EXACT [] xref: Wikipedia:Quorum_sensing is_a: GO:0007267 ! cell-cell signaling is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0060245 ! detection of cell density [Term] id: GO:0009408 name: response to heat namespace: biological_process alt_id: GO:0006951 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] subset: goslim_yeast synonym: "response to heat shock" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009409 name: response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] synonym: "freezing tolerance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009410 name: response to xenobiotic stimulus namespace: biological_process alt_id: GO:0017104 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009411 name: response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] synonym: "response to ultraviolet light stimulus" EXACT [] synonym: "response to ultraviolet radiation stimulus" EXACT [] synonym: "response to UV light stimulus" EXACT [] synonym: "response to UV radiation stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009414 name: response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] synonym: "drought tolerance" RELATED [] synonym: "response to dehydration" EXACT [] synonym: "response to drought" EXACT [] synonym: "response to thirst" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009415 name: response to water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] synonym: "response to water stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: goslim_plant is_a: GO:0009314 ! response to radiation [Term] id: GO:0009453 name: energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423] synonym: "energytaxis" EXACT [] synonym: "taxis in response to energy source" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0009507 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] subset: goslim_plant xref: Wikipedia:Chloroplast is_a: GO:0009536 ! plastid property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009526 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] is_a: GO:0031967 ! organelle envelope relationship: part_of GO:0009536 ! plastid [Term] id: GO:0009532 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:0943088399] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009536 ! plastid [Term] id: GO:0009533 name: chloroplast stromal thylakoid namespace: cellular_component def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943088399] is_a: GO:0009534 ! chloroplast thylakoid intersection_of: GO:0009534 ! chloroplast thylakoid intersection_of: part_of GO:0009570 ! chloroplast stroma relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009534 name: chloroplast thylakoid namespace: cellular_component def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943088399] is_a: GO:0031976 ! plastid thylakoid intersection_of: GO:0009579 ! thylakoid intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant xref: Wikipedia:Plastid is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 [Term] id: GO:0009537 name: proplastid namespace: cellular_component def: "The precursor of other plastids." [ISBN:0943088399] is_a: GO:0009536 ! plastid [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0009570 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009571 name: proplastid stroma namespace: cellular_component def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009537 ! proplastid [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular property_value: RO:0002161 NCBITaxon:33208 [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009589 name: detection of UV namespace: biological_process def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732] synonym: "detection of ultraviolet light stimulus" EXACT [] synonym: "detection of ultraviolet radiation stimulus" EXACT [] synonym: "detection of UV light stimulus" EXACT [] synonym: "detection of UV radiation stimulus" EXACT [] synonym: "perception of UV" RELATED [] is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009595 name: detection of biotic stimulus namespace: biological_process alt_id: GO:0009596 def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb] synonym: "perception of biotic stimulus" RELATED [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_drosophila subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009611 name: response to wounding namespace: biological_process alt_id: GO:0002245 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] synonym: "physiological response to wounding" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0009615 name: response to virus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] synonym: "response to viruses" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16572 xsd:anyURI [Term] id: GO:0009636 name: response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] subset: goslim_chembl synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009637 name: response to blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red] synonym: "response to blue light stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009639 name: response to red or far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009642 name: response to light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009644 name: response to high light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009645 name: response to low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009646 name: response to absence of light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators] synonym: "response to darkness" RELATED [] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009651 name: response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to ionic osmotic stress" EXACT [] synonym: "salinity response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009725 name: response to hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] synonym: "response to hormone stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0009785 name: blue light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm] synonym: "blue light signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0071483 ! cellular response to blue light [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008356 ! asymmetric cell division relationship: regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0009856 name: pollination namespace: biological_process def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion." [GOC:tb, PMID:10973091] subset: goslim_plant xref: Wikipedia:Pollination is_a: GO:0022414 ! reproductive process relationship: part_of GO:0044706 ! multi-multicellular organism process [Term] id: GO:0009887 name: animal organ morphogenesis namespace: biological_process def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development property_value: RO:0002161 NCBITaxon:147554 property_value: RO:0002161 NCBITaxon:33630 property_value: RO:0002161 NCBITaxon:33682 property_value: RO:0002161 NCBITaxon:38254 property_value: RO:0002161 NCBITaxon:4891 [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009058 ! biosynthetic process relationship: regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009058 ! biosynthetic process relationship: negatively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009058 ! biosynthetic process relationship: positively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process alt_id: GO:0044252 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008152 ! metabolic process relationship: negatively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process alt_id: GO:0044253 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008152 ! metabolic process relationship: positively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009056 ! catabolic process relationship: regulates GO:0009056 ! catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009056 ! catabolic process relationship: negatively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009056 ! catabolic process relationship: positively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009941 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007165 ! signal transduction relationship: regulates GO:0007165 ! signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process alt_id: GO:0035468 def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007165 ! signal transduction relationship: positively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process alt_id: GO:0035467 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007165 ! signal transduction relationship: negatively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0044763 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0009991 name: response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0010017 name: red or far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "phytochrome signaling pathway" BROAD [] synonym: "red or far red light signaling pathway" EXACT [GOC:bf, GOC:tb] synonym: "red or far-red light signal transduction" EXACT [GOC:signaling] synonym: "red or far-red light signalling pathway" EXACT [] synonym: "red/far red light signaling pathway" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071489 ! cellular response to red or far red light [Term] id: GO:0010018 name: far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "far red light signalling pathway" EXACT [] synonym: "far red signaling pathway" EXACT [GOC:tb] synonym: "far-red light signal transduction" EXACT [GOC:signaling] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071490 ! cellular response to far red light [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0010033 name: response to organic substance namespace: biological_process alt_id: GO:1990367 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676] synonym: "process resulting in tolerance to organic substance" NARROW [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010035 name: response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010114 name: response to red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "response to red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010161 name: red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "red light phototransduction" EXACT [GOC:signaling] synonym: "red light signal transduction" EXACT [GOC:signaling] synonym: "red light signalling pathway" EXACT [] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071491 ! cellular response to red light [Term] id: GO:0010165 name: response to X-ray namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] synonym: "response to X-ray radiation stimulus" EXACT [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010185 name: regulation of cellular defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "regulation of cellular defence response" EXACT [] is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006968 ! cellular defense response relationship: regulates GO:0006968 ! cellular defense response [Term] id: GO:0010186 name: positive regulation of cellular defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "activation of cellular defense response" NARROW [] synonym: "positive regulation of cellular defence response" EXACT [] synonym: "stimulation of cellular defense response" NARROW [] synonym: "up regulation of cellular defense response" EXACT [] synonym: "up-regulation of cellular defense response" EXACT [] synonym: "upregulation of cellular defense response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031349 ! positive regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006968 ! cellular defense response relationship: positively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0010212 name: response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] synonym: "response to ionising radiation" EXACT [] synonym: "response to ionizing radiation stimulus" EXACT [] is_a: GO:0009314 ! response to radiation [Term] id: GO:0010218 name: response to far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb] synonym: "response to far red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010224 name: response to UV-B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb] synonym: "response to medium wave ultraviolet light stimulus" EXACT [] synonym: "response to medium wave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-B light stimulus" EXACT [] synonym: "response to UV-B radiation stimulus" EXACT [] synonym: "response to UVB light stimulus" EXACT [] synonym: "response to UVB radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010225 name: response to UV-C namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb] synonym: "response to germicidal ultraviolet light stimulus" EXACT [] synonym: "response to germicidal ultraviolet radiation stimulus" EXACT [] synonym: "response to shortwave ultraviolet light stimulus" EXACT [] synonym: "response to shortwave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-C light stimulus" EXACT [] synonym: "response to UV-C radiation stimulus" EXACT [] synonym: "response to UVC light stimulus" EXACT [] synonym: "response to UVC radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010226 name: response to lithium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010243 name: response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [PMID:9869419] synonym: "response to organic nitrogen" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] subset: goslim_drosophila synonym: "endomembrane organization" EXACT [] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0010324 name: membrane invagination namespace: biological_process alt_id: GO:1902534 def: "The infolding of a membrane." [GOC:tb] subset: goslim_yeast synonym: "single-organism membrane invagination" RELATED [] is_a: GO:0061024 ! membrane organization created_by: jl creation_date: 2013-12-02T13:58:34Z [Term] id: GO:0010332 name: response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] synonym: "response to gamma ray" RELATED [] synonym: "response to gamma-ray photon" RELATED [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010466 name: negative regulation of peptidase activity namespace: biological_process def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008233 ! peptidase activity relationship: negatively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010467 ! gene expression relationship: regulates GO:0010467 ! gene expression [Term] id: GO:0010469 name: regulation of signaling receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] synonym: "regulation of receptor activity" BROAD [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038023 ! signaling receptor activity relationship: regulates GO:0038023 ! signaling receptor activity [Term] id: GO:0010506 name: regulation of autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006914 ! autophagy relationship: regulates GO:0006914 ! autophagy [Term] id: GO:0010507 name: negative regulation of autophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031330 ! negative regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006914 ! autophagy relationship: negatively_regulates GO:0006914 ! autophagy [Term] id: GO:0010508 name: positive regulation of autophagy namespace: biological_process def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031331 ! positive regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006914 ! autophagy relationship: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0010543 name: regulation of platelet activation namespace: biological_process def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030168 ! platelet activation relationship: regulates GO:0030168 ! platelet activation [Term] id: GO:0010544 name: negative regulation of platelet activation namespace: biological_process def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030168 ! platelet activation relationship: negatively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process relationship: regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010559 name: regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:1903018 ! regulation of glycoprotein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009101 ! glycoprotein biosynthetic process relationship: regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010560 name: positive regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009101 ! glycoprotein biosynthetic process relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010561 name: negative regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006793 ! phosphorus metabolic process relationship: positively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006793 ! phosphorus metabolic process relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022402 ! cell cycle process relationship: regulates GO:0022402 ! cell cycle process [Term] id: GO:0010572 name: positive regulation of platelet activation namespace: biological_process def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030168 ! platelet activation relationship: positively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043170 ! macromolecule metabolic process relationship: positively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043170 ! macromolecule metabolic process relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010608 name: posttranscriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010623 name: programmed cell death involved in cell development namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. synonym: "developmental programmed cell death" BROAD [] synonym: "programmed cell death involved in development" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0012501 ! programmed cell death intersection_of: part_of GO:0048468 ! cell development relationship: part_of GO:0048468 ! cell development [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010467 ! gene expression relationship: positively_regulates GO:0010467 ! gene expression [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010467 ! gene expression relationship: negatively_regulates GO:0010467 ! gene expression [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006996 ! organelle organization relationship: positively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006996 ! organelle organization relationship: negatively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007154 ! cell communication relationship: regulates GO:0007154 ! cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007154 ! cell communication relationship: positively_regulates GO:0007154 ! cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007154 ! cell communication relationship: negatively_regulates GO:0007154 ! cell communication [Term] id: GO:0010672 name: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900401 def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:12161753] synonym: "regulation of meiosis by regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: mah creation_date: 2012-04-20T02:45:12Z [Term] id: GO:0010673 name: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900476 def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0051039 ! positive regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: dianna.fisk creation_date: 2012-05-01T08:40:11Z [Term] id: GO:0010674 name: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900475 def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0051038 ! negative regulation of transcription involved in meiotic cell cycle intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: dianna.fisk creation_date: 2012-05-01T08:39:58Z [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048468 ! cell development relationship: positively_regulates GO:0048468 ! cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048468 ! cell development relationship: negatively_regulates GO:0048468 ! cell development [Term] id: GO:0010767 name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0034644 ! cellular response to UV is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0010768 name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [Term] id: GO:0010821 name: regulation of mitochondrion organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007005 ! mitochondrion organization relationship: regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010822 name: positive regulation of mitochondrion organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "positive regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007005 ! mitochondrion organization relationship: positively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010823 name: negative regulation of mitochondrion organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "negative regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007005 ! mitochondrion organization relationship: negatively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032989 ! cellular component morphogenesis [Term] id: GO:0010941 name: regulation of cell death namespace: biological_process def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008219 ! cell death relationship: regulates GO:0008219 ! cell death [Term] id: GO:0010942 name: positive regulation of cell death namespace: biological_process def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008219 ! cell death relationship: positively_regulates GO:0008219 ! cell death [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022402 ! cell cycle process relationship: negatively_regulates GO:0022402 ! cell cycle process created_by: tanyaberardini creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010952 name: positive regulation of peptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008233 ! peptidase activity relationship: positively_regulates GO:0008233 ! peptidase activity created_by: tanyaberardini creation_date: 2009-04-27T11:54:32Z [Term] id: GO:0010960 name: magnesium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis created_by: tanyaberardini creation_date: 2009-05-06T11:47:17Z [Term] id: GO:0010970 name: transport along microtubule namespace: biological_process def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] synonym: "microtubule-based transport" BROAD [] synonym: "movement along microtubule" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0099111 ! microtubule-based transport created_by: tanyaberardini creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031175 ! neuron projection development relationship: regulates GO:0031175 ! neuron projection development created_by: tanyaberardini creation_date: 2009-06-01T10:44:45Z [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0045666 ! positive regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031175 ! neuron projection development relationship: positively_regulates GO:0031175 ! neuron projection development created_by: tanyaberardini creation_date: 2009-06-01T10:46:44Z [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "growth cone collapse" RELATED [GOC:pr] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0045665 ! negative regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031175 ! neuron projection development relationship: negatively_regulates GO:0031175 ! neuron projection development created_by: tanyaberardini creation_date: 2009-06-01T10:47:42Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0031982 ! vesicle [Term] id: GO:0012507 name: ER to Golgi transport vesicle membrane namespace: cellular_component alt_id: GO:0030664 def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII coated vesicle membrane" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT [] synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT [] synonym: "ER to Golgi constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "ER-Golgi transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030134 ! COPII-coated ER to Golgi transport vesicle [Term] id: GO:0012511 name: monolayer-surrounded lipid storage body namespace: cellular_component alt_id: GO:0009520 def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372] synonym: "oil body" EXACT [] synonym: "oilbody" EXACT [] synonym: "oleosome" EXACT [] synonym: "spherosome" EXACT [] xref: Wikipedia:Oil_body is_a: GO:0005811 ! lipid droplet [Term] id: GO:0014041 name: regulation of neuron maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042551 ! neuron maturation relationship: regulates GO:0042551 ! neuron maturation [Term] id: GO:0014042 name: positive regulation of neuron maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "activation of neuron maturation" NARROW [] synonym: "stimulation of neuron maturation" NARROW [] synonym: "up regulation of neuron maturation" EXACT [] synonym: "up-regulation of neuron maturation" EXACT [] synonym: "upregulation of neuron maturation" EXACT [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1903431 ! positive regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042551 ! neuron maturation relationship: positively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014043 name: negative regulation of neuron maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "down regulation of neuron maturation" EXACT [] synonym: "down-regulation of neuron maturation" EXACT [] synonym: "downregulation of neuron maturation" EXACT [] synonym: "inhibition of neuron maturation" NARROW [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1903430 ! negative regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042551 ! neuron maturation relationship: negatively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014069 name: postsynaptic density namespace: cellular_component alt_id: GO:0097481 alt_id: GO:0097483 def: "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density] subset: goslim_synapse synonym: "neuronal postsynaptic density" EXACT [GO:0097481] synonym: "post synaptic density" EXACT [] synonym: "post-synaptic density" EXACT [] synonym: "postsynaptic density of dendrite" NARROW [] xref: NIF_Subcellular:sao1196688972 xref: Wikipedia:Postsynaptic_density is_a: GO:0099572 ! postsynaptic specialization intersection_of: GO:0099572 ! postsynaptic specialization intersection_of: part_of GO:0032279 ! asymmetric synapse relationship: part_of GO:0032279 ! asymmetric synapse created_by: paola creation_date: 2013-07-02T09:44:28Z [Term] id: GO:0014070 name: response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:ef] synonym: "response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0014072 name: response to isoquinoline alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0014075 name: response to amine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef] synonym: "response to amine stimulus" EXACT [GOC:dos] is_a: GO:0010243 ! response to organonitrogen compound [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] is_a: GO:0015833 ! peptide transport is_a: GO:0045184 ! establishment of protein localization [Term] id: GO:0015075 name: ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "ion transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0034220 ! ion transmembrane transport [Term] id: GO:0015318 name: inorganic molecular entity transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729] subset: gocheck_do_not_annotate synonym: "inorganic solute uptake transmembrane transporter activity" EXACT [] synonym: "inorganic uptake permease activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14372 xsd:anyURI [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] is_a: GO:0006820 ! anion transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015884 name: folic acid transport namespace: biological_process def: "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transport" EXACT [] synonym: "vitamin B9 transport" EXACT [] synonym: "vitamin M transport" EXACT [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015893 name: drug transport namespace: biological_process def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport relationship: part_of GO:0042493 ! response to drug [Term] id: GO:0015939 name: pantothenate metabolic process namespace: biological_process alt_id: GO:0006770 def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate metabolism" EXACT [] synonym: "vitamin B5 metabolic process" EXACT [] synonym: "vitamin B5 metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Biological_membrane is_a: CARO:0000003 ! anatomical structure is_a: GO:0110165 ! cellular anatomical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] xref: MIPS_funcat:42 is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016049 name: cell growth namespace: biological_process alt_id: GO:0048591 def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_pir subset: goslim_plant synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0016056 name: rhodopsin mediated signaling pathway namespace: biological_process alt_id: GO:0009586 def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb] synonym: "rhodopsin mediated phototransduction" EXACT [GOC:bf] synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb] synonym: "rhodopsin signaling" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007602 ! phototransduction is_a: GO:0071482 ! cellular response to light stimulus relationship: part_of GO:0007603 ! phototransduction, visible light [Term] id: GO:0016064 name: immunoglobulin mediated immune response namespace: biological_process def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "antibody-mediated immune response" EXACT [] is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir synonym: "RNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0016101 name: diterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684] synonym: "diterpene metabolic process" NARROW [] synonym: "diterpene metabolism" NARROW [] synonym: "diterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016119 name: carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684] synonym: "carotene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process [Term] id: GO:0016236 name: macroautophagy namespace: biological_process alt_id: GO:0034262 def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities. synonym: "autophagy" BROAD [] is_a: GO:0006914 ! autophagy [Term] id: GO:0016239 name: positive regulation of macroautophagy namespace: biological_process def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] synonym: "activation of macroautophagy" NARROW [] synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "stimulation of macroautophagy" NARROW [] synonym: "up regulation of macroautophagy" EXACT [] synonym: "up-regulation of macroautophagy" EXACT [] synonym: "upregulation of macroautophagy" EXACT [] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0016241 ! regulation of macroautophagy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016236 ! macroautophagy relationship: positively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016241 name: regulation of macroautophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016236 ! macroautophagy relationship: regulates GO:0016236 ! macroautophagy [Term] id: GO:0016242 name: negative regulation of macroautophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] synonym: "down regulation of macroautophagy" EXACT [] synonym: "down-regulation of macroautophagy" EXACT [] synonym: "downregulation of macroautophagy" EXACT [] synonym: "inhibition of macroautophagy" NARROW [] synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0016241 ! regulation of macroautophagy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016236 ! macroautophagy relationship: negatively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016246 name: RNA interference namespace: biological_process def: "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'. synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah] synonym: "RNAi" EXACT [] xref: Wikipedia:RNA_interference is_a: GO:0035194 ! posttranscriptional gene silencing by RNA property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups relationship: part_of GO:0016310 ! phosphorylation [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016321 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0007143 ! female meiotic nuclear division relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0016441 name: posttranscriptional gene silencing namespace: biological_process def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054] synonym: "cosuppression" RELATED [] synonym: "post-transcriptional gene silencing" EXACT [GOC:vw] synonym: "PTGS" EXACT [] synonym: "quelling" EXACT [] xref: Wikipedia:Post_transcriptional_gene_silencing is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0016458 ! gene silencing is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0016458 name: gene silencing namespace: biological_process def: "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] comment: This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class. subset: goslim_drosophila subset: goslim_pir synonym: "long-term maintenance of gene inactivation" NARROW [] xref: Wikipedia:Gene_silencing is_a: GO:0009987 ! cellular process is_a: GO:0010629 ! negative regulation of gene expression [Term] id: GO:0016482 name: cytosolic transport namespace: biological_process def: "The directed movement of substances or organelles within the cytosol." [GOC:ai] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005829 ! cytosol relationship: occurs_in GO:0005829 ! cytosol [Term] id: GO:0016525 name: negative regulation of angiogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] synonym: "down regulation of angiogenesis" EXACT [] synonym: "down-regulation of angiogenesis" EXACT [] synonym: "downregulation of angiogenesis" EXACT [] synonym: "inhibition of angiogenesis" NARROW [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001525 ! angiogenesis relationship: negatively_regulates GO:0001525 ! angiogenesis [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:2 xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: Reactome:R-HSA-6787403 "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:3 xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016877 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2, GOC:mah] synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016879 name: ligase activity, forming carbon-nitrogen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] synonym: "other carbon-nitrogen ligase activity" NARROW [] xref: EC:6.3 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016881 name: acid-amino acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] synonym: "peptide synthase activity" EXACT [] xref: EC:6.3.2 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016922 name: nuclear receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974] synonym: "ligand-dependent nuclear receptor binding" EXACT [] synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0017144 name: drug metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2] subset: goslim_chembl subset: goslim_pir synonym: "drug metabolism" EXACT [] xref: Wikipedia:Drug_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0017145 name: stem cell division namespace: biological_process def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] synonym: "stem cell renewal" EXACT [] is_a: GO:0051301 ! cell division [Term] id: GO:0018130 name: heterocycle biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] synonym: "heterocycle anabolism" EXACT [] synonym: "heterocycle biosynthesis" EXACT [] synonym: "heterocycle formation" EXACT [] synonym: "heterocycle synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018995 name: host cellular component namespace: cellular_component def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732] synonym: "host organism" EXACT [] xref: Wikipedia:Host_(biology) is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process alt_id: GO:0033057 alt_id: GO:0044704 def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] subset: goslim_drosophila synonym: "multicellular organism reproductive behavior" NARROW [] synonym: "reproductive behavior in a multicellular organism" EXACT [] synonym: "reproductive behaviour" EXACT [] synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0007610 ! behavior intersection_of: part_of GO:0000003 ! reproduction created_by: janelomax creation_date: 2012-09-19T16:01:37Z [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "regulation of lipid metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006629 ! lipid metabolic process relationship: regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008152 ! metabolic process relationship: regulates GO:0008152 ! metabolic process [Term] id: GO:0019233 name: sensory perception of pain namespace: biological_process def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators] synonym: "nociception" EXACT [] synonym: "perception of physiological pain" NARROW [] xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception [Term] id: GO:0019438 name: aromatic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound anabolism" EXACT [] synonym: "aromatic compound biosynthesis" EXACT [] synonym: "aromatic compound formation" EXACT [] synonym: "aromatic compound synthesis" EXACT [] synonym: "aromatic hydrocarbon biosynthesis" NARROW [] synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019637 name: organophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] synonym: "organophosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0019693 name: ribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] synonym: "ribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019724 name: B cell mediated immunity namespace: biological_process def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "B lymphocyte mediated immune effector process" EXACT [] synonym: "B lymphocyte mediated immunity" EXACT [] synonym: "B-cell mediated immune effector process" EXACT [] synonym: "B-cell mediated immunity" EXACT [] synonym: "B-lymphocyte mediated immune effector process" EXACT [] synonym: "B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_aspergillus subset: goslim_candida subset: goslim_plant is_a: GO:0009987 ! cellular process is_a: GO:0042592 ! homeostatic process [Term] id: GO:0019747 name: regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] synonym: "regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006720 ! isoprenoid metabolic process relationship: regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "carboxylic acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0019777 name: Atg12 transferase activity namespace: molecular_function def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404] synonym: "APG12 conjugating enzyme activity" NARROW [] synonym: "APG12 ligase activity" NARROW [] synonym: "Atg12 conjugating enzyme activity" NARROW [] synonym: "Atg12 ligase activity" NARROW [] xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019778 name: Atg12 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG12 activating enzyme activity" RELATED [GOC:vw] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019783 name: ubiquitin-like protein-specific protease activity namespace: molecular_function alt_id: GO:1904454 alt_id: GO:1904455 def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah] synonym: "small conjugating protein-specific protease activity" EXACT [GOC:dph] synonym: "ubiquitin-like specific protease activity" NARROW [] synonym: "ubiquitin-like-protein-specific protease activity" NARROW [] synonym: "ubiquitin-specific protease activity involved in negative regulation of ERAD pathway" NARROW [] synonym: "ubiquitin-specific protease activity involved in positive regulation of ERAD pathway" NARROW [] is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0019786 name: Atg8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah] synonym: "APG8-PE hydrolase" RELATED [] synonym: "APG8-specific protease activity" RELATED [GOC:vw] is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0019787 name: small conjugating protein ligase activity name: ubiquitin-like protein transferase activity namespace: molecular_function alt_id: GO:0008639 alt_id: GO:0008640 def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: goslim_drosophila subset: goslim_pir synonym: "E2" RELATED [] synonym: "E3" RELATED [dph:GOC] synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] synonym: "small protein conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE" xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated" is_a: GO:0016740 ! transferase activity is_a: GO:0016881 ! acid-amino acid ligase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0016020 ! membrane [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, GOC:kmv, GOC:krc, GOC:tb, ISBN:0387520546, Wikipedia:Sexual_reproduction] comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction is_a: GO:0044703 ! multi-organism reproductive process [Term] id: GO:0019954 name: asexual reproduction namespace: biological_process def: "The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546] synonym: "parthenogenesis" RELATED [Wikipedia:Parthenogenesis] xref: Wikipedia:Asexual_reproduction is_a: GO:0000003 ! reproduction [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] subset: goslim_chembl subset: goslim_generic is_a: GO:0032502 ! developmental process [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] synonym: "nervous system cell generation" EXACT systematic_synonym [] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0022400 name: regulation of rhodopsin mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah] synonym: "regulation of rhodopsin mediated signalling" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016056 ! rhodopsin mediated signaling pathway relationship: regulates GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684] subset: goslim_pir synonym: "membrane docking" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0022407 name: regulation of cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098609 ! cell-cell adhesion relationship: regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022408 name: negative regulation of cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "down regulation of cell-cell adhesion" EXACT [] synonym: "down-regulation of cell-cell adhesion" EXACT [] synonym: "downregulation of cell-cell adhesion" EXACT [] synonym: "inhibition of cell-cell adhesion" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098609 ! cell-cell adhesion relationship: negatively_regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022409 name: positive regulation of cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "activation of cell-cell adhesion" NARROW [] synonym: "stimulation of cell-cell adhesion" NARROW [] synonym: "up regulation of cell-cell adhesion" EXACT [] synonym: "up-regulation of cell-cell adhesion" EXACT [] synonym: "upregulation of cell-cell adhesion" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0045785 ! positive regulation of cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098609 ! cell-cell adhesion relationship: positively_regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022410 name: circadian sleep/wake cycle process namespace: biological_process def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0032504 ! multicellular organism reproduction relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0044702 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] synonym: "single organism reproductive process" RELATED [] is_a: GO:0008150 ! biological_process intersection_of: GO:0008150 ! biological_process intersection_of: part_of GO:0000003 ! reproduction disjoint_from: GO:0044848 ! biological phase relationship: part_of GO:0000003 ! reproduction created_by: janelomax creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009653 ! anatomical structure morphogenesis relationship: regulates GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0044085 ! cellular component biogenesis [Term] id: GO:0022610 name: biological adhesion namespace: biological_process def: "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete] subset: goslim_pir is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015563 alt_id: GO:0015646 alt_id: GO:0022891 alt_id: GO:0022892 def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" RELATED [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" is_a: GO:0005215 ! transporter activity relationship: part_of GO:0055085 ! transmembrane transport [Term] id: GO:0022898 name: regulation of transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022857 ! transmembrane transporter activity relationship: regulates GO:0022857 ! transmembrane transporter activity [Term] id: GO:0023014 name: signal transduction by protein phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] synonym: "signal transduction via phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via phosphorylation event" RELATED [GOC:bf] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0007165 ! signal transduction creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0010468 ! regulation of gene expression relationship: part_of GO:0010468 ! regulation of gene expression creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0023052 ! signaling relationship: regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 alt_id: GO:0044700 def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pombe subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] synonym: "single organism signaling" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0023052 ! signaling relationship: positively_regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0023052 ! signaling relationship: negatively_regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023061 name: signal release namespace: biological_process def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] synonym: "signal secretion" EXACT [GOC:bf] is_a: GO:0032940 ! secretion by cell intersection_of: GO:0032940 ! secretion by cell intersection_of: part_of GO:0007267 ! cell-cell signaling relationship: part_of GO:0007267 ! cell-cell signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0030003 name: cellular cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cations at the level of a cell." [GOC:ceb, GOC:mah] is_a: GO:0006873 ! cellular ion homeostasis is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization [Term] id: GO:0030054 name: cell junction namespace: cellular_component def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon xref: Wikipedia:Cell_junction is_a: GO:0110165 ! cellular anatomical entity property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0030075 name: bacterial thylakoid namespace: cellular_component def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane-derived thylakoid" EXACT [] is_a: GO:0009579 ! thylakoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0030097 name: hemopoiesis namespace: biological_process def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] synonym: "blood cell biosynthesis" EXACT [] synonym: "blood cell formation" EXACT [] synonym: "haemopoiesis" EXACT [] synonym: "hematopoiesis" EXACT [] xref: Wikipedia:Haematopoiesis is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0030099 name: myeloid cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0030101 name: natural killer cell activation namespace: biological_process def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] synonym: "NK cell activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" RELATED [] xref: NIF_Subcellular:sao885490876 is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030134 name: COPII-coated ER to Golgi transport vesicle namespace: cellular_component alt_id: GO:0030138 alt_id: GO:0140045 def: "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII] synonym: "COPII vesicle" RELATED [] synonym: "COPII-associated ER to Golgi transport vesicle" EXACT [] synonym: "COPII-associated vesicle" EXACT [] synonym: "COPII-coated vesicle" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle" RELATED [] synonym: "endoplasmic reticulum-Golgi transport vesicle" RELATED [] synonym: "ER to Golgi constitutive secretory pathway transport vesicle" RELATED [] synonym: "ER to Golgi transport vesicle" RELATED [] synonym: "ER-Golgi transport vesicle" RELATED [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030135 ! coated vesicle created_by: pg creation_date: 2017-06-22T16:26:57Z [Term] id: GO:0030135 name: coated vesicle namespace: cellular_component alt_id: GO:0005909 def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] subset: goslim_drosophila xref: NIF_Subcellular:sao1985096626 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030141 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0099503 ! secretory vesicle relationship: part_of GO:0012505 ! endomembrane system property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0030155 name: regulation of cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] synonym: "cell adhesion receptor regulator activity" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007155 ! cell adhesion relationship: regulates GO:0007155 ! cell adhesion [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006508 ! proteolysis relationship: regulates GO:0006508 ! proteolysis [Term] id: GO:0030168 name: platelet activation namespace: biological_process def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/] synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde] is_a: GO:0001775 ! cell activation relationship: part_of GO:0007596 ! blood coagulation [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0030193 name: regulation of blood coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050818 ! regulation of coagulation is_a: GO:0061041 ! regulation of wound healing is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007596 ! blood coagulation relationship: regulates GO:0007596 ! blood coagulation [Term] id: GO:0030194 name: positive regulation of blood coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "activation of blood coagulation" NARROW [] synonym: "stimulation of blood coagulation" NARROW [] synonym: "up regulation of blood coagulation" EXACT [] synonym: "up-regulation of blood coagulation" EXACT [] synonym: "upregulation of blood coagulation" EXACT [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050820 ! positive regulation of coagulation is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1900048 ! positive regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007596 ! blood coagulation relationship: positively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030195 name: negative regulation of blood coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "down regulation of blood coagulation" EXACT [] synonym: "down-regulation of blood coagulation" EXACT [] synonym: "downregulation of blood coagulation" EXACT [] synonym: "inhibition of blood coagulation" NARROW [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050819 ! negative regulation of coagulation is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1900047 ! negative regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007596 ! blood coagulation relationship: negatively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0030218 name: erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] synonym: "erythrocyte cell differentiation" EXACT [] synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "RBC differentiation" EXACT [CL:0000232] synonym: "red blood cell differentiation" EXACT [CL:0000232] xref: Wikipedia:Erythropoiesis is_a: GO:0030099 ! myeloid cell differentiation relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process alt_id: GO:0000068 def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] is_a: GO:0006323 ! DNA packaging [Term] id: GO:0030262 name: apoptotic nuclear changes namespace: biological_process def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis] synonym: "apoptotic nuclear change" NARROW [] is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis [Term] id: GO:0030263 name: apoptotic chromosome condensation namespace: biological_process def: "The compaction of chromatin during apoptosis." [GOC:mah] synonym: "pyknosis" EXACT [] xref: Wikipedia:Pyknosis is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0030284 name: estrogen receptor activity namespace: molecular_function def: "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:signaling, PMID:17615392] comment: For estrogen receptors that function within the nucleus to modulate transcription, consider instead annotating to the child terms 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052' or 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016049 ! cell growth relationship: positively_regulates GO:0016049 ! cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016049 ! cell growth relationship: negatively_regulates GO:0016049 ! cell growth [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0030313 name: cell envelope namespace: cellular_component def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm] subset: goslim_pir xref: Wikipedia:Cell_envelope is_a: GO:0031975 ! envelope relationship: has_part GO:0005886 ! plasma membrane [Term] id: GO:0030317 name: flagellated sperm motility namespace: biological_process def: "Any process involved in the controlled movement of a flagellated sperm cell." [GOC:cilia, GOC:jl, GOC:krc] synonym: "flagellated sperm movement" EXACT [] synonym: "sperm motility" BROAD [] synonym: "sperm movement" BROAD [] xref: Wikipedia:Sperm_motility is_a: GO:0060285 ! cilium-dependent cell motility is_a: GO:0097722 ! sperm motility [Term] id: GO:0030430 name: host cell cytoplasm namespace: cellular_component alt_id: GO:0097679 def: "The cytoplasm of a host cell." [GOC:mah] synonym: "other organism cytoplasm" RELATED [] is_a: GO:0033646 ! host intracellular part created_by: paola creation_date: 2014-12-01T14:14:21Z [Term] id: GO:0030431 name: sleep namespace: biological_process def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] subset: goslim_pir synonym: "diapause" RELATED [] synonym: "dormancy" RELATED [] synonym: "lethargus" RELATED [] xref: Wikipedia:Sleep is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030522 name: intracellular receptor signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] synonym: "intracellular receptor mediated signaling pathway" EXACT [] synonym: "intracellular receptor-mediated signaling pathway" EXACT [] synonym: "intracellular receptor-mediated signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0030545 name: receptor regulator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb] xref: MIPS_funcat:18.02.07 is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0030546 name: signaling receptor activator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] synonym: "receptor activator activity" BROAD [] is_a: GO:0030545 ! receptor regulator activity [Term] id: GO:0030581 name: symbiont intracellular protein transport in host namespace: biological_process alt_id: GO:0051708 def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "host cell protein transport" EXACT [] synonym: "intracellular protein transport in host" EXACT [] synonym: "intracellular protein transport in other organism during symbiotic interaction" BROAD [GOC:dph] synonym: "intracellular protein transport in other organism involved in symbiotic interaction" BROAD [] is_a: GO:0015031 ! protein transport is_a: GO:0051701 ! interaction with host intersection_of: GO:0015031 ! protein transport intersection_of: occurs_in GO:0043657 ! host cell relationship: occurs_in GO:0043657 ! host cell [Term] id: GO:0030656 name: regulation of vitamin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah] synonym: "regulation of vitamin metabolism" EXACT [] is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006766 ! vitamin metabolic process relationship: regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0030658 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030133 ! transport vesicle [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] is_a: GO:0012506 ! vesicle membrane relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030660 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0005798 ! Golgi-associated vesicle [Term] id: GO:0030662 name: coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030135 ! coated vesicle [Term] id: GO:0030667 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030141 ! secretory granule [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic is_a: GO:0046907 ! intracellular transport [Term] id: GO:0030728 name: ovulation namespace: biological_process def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] xref: Wikipedia:Ovulation is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0030808 name: regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "regulation of nucleotide anabolism" EXACT [] synonym: "regulation of nucleotide biosynthesis" EXACT [] synonym: "regulation of nucleotide formation" EXACT [] synonym: "regulation of nucleotide synthesis" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009165 ! nucleotide biosynthetic process relationship: regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030809 name: negative regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "down regulation of nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] synonym: "downregulation of nucleotide biosynthetic process" EXACT [] synonym: "inhibition of nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of nucleotide anabolism" EXACT [] synonym: "negative regulation of nucleotide biosynthesis" EXACT [] synonym: "negative regulation of nucleotide formation" EXACT [] synonym: "negative regulation of nucleotide synthesis" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009165 ! nucleotide biosynthetic process relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030810 name: positive regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "activation of nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of nucleotide anabolism" EXACT [] synonym: "positive regulation of nucleotide biosynthesis" EXACT [] synonym: "positive regulation of nucleotide formation" EXACT [] synonym: "positive regulation of nucleotide synthesis" EXACT [] synonym: "stimulation of nucleotide biosynthetic process" NARROW [] synonym: "up regulation of nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] synonym: "upregulation of nucleotide biosynthetic process" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009165 ! nucleotide biosynthetic process relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030990 name: intraciliary transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. subset: goslim_pir synonym: "IFT complex" RELATED [] synonym: "intraflagellar transport complex" EXACT [] synonym: "intraflagellar transport particle" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component alt_id: GO:0005578 def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "matrisome" NARROW [] synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0031047 name: gene silencing by RNA namespace: biological_process def: "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016458 ! gene silencing [Term] id: GO:0031049 name: programmed DNA elimination namespace: biological_process def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0031052 name: chromosome breakage namespace: biological_process def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns] comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0031049 ! programmed DNA elimination [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: part_of GO:0048666 ! neuron development relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0031268 name: pseudopodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] synonym: "pseudopodium organisation" EXACT [] synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0031323 name: regulation of cellular metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "regulation of cellular metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044237 ! cellular metabolic process relationship: regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031324 name: negative regulation of cellular metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "down regulation of cellular metabolic process" EXACT [] synonym: "down-regulation of cellular metabolic process" EXACT [] synonym: "downregulation of cellular metabolic process" EXACT [] synonym: "inhibition of cellular metabolic process" NARROW [] synonym: "negative regulation of cellular metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process relationship: negatively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "activation of cellular metabolic process" NARROW [] synonym: "positive regulation of cellular metabolism" EXACT [] synonym: "stimulation of cellular metabolic process" NARROW [] synonym: "up regulation of cellular metabolic process" EXACT [] synonym: "up-regulation of cellular metabolic process" EXACT [] synonym: "upregulation of cellular metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044237 ! cellular metabolic process relationship: positively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031326 name: regulation of cellular biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular anabolism" EXACT [] synonym: "regulation of cellular biosynthesis" EXACT [] synonym: "regulation of cellular formation" EXACT [] synonym: "regulation of cellular synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044249 ! cellular biosynthetic process relationship: regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031327 name: negative regulation of cellular biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular biosynthetic process" EXACT [] synonym: "down-regulation of cellular biosynthetic process" EXACT [] synonym: "downregulation of cellular biosynthetic process" EXACT [] synonym: "inhibition of cellular biosynthetic process" NARROW [] synonym: "negative regulation of cellular anabolism" EXACT [] synonym: "negative regulation of cellular biosynthesis" EXACT [] synonym: "negative regulation of cellular formation" EXACT [] synonym: "negative regulation of cellular synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031328 name: positive regulation of cellular biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular biosynthetic process" NARROW [] synonym: "positive regulation of cellular anabolism" EXACT [] synonym: "positive regulation of cellular biosynthesis" EXACT [] synonym: "positive regulation of cellular formation" EXACT [] synonym: "positive regulation of cellular synthesis" EXACT [] synonym: "stimulation of cellular biosynthetic process" NARROW [] synonym: "up regulation of cellular biosynthetic process" EXACT [] synonym: "up-regulation of cellular biosynthetic process" EXACT [] synonym: "upregulation of cellular biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process relationship: positively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031329 name: regulation of cellular catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular breakdown" EXACT [] synonym: "regulation of cellular catabolism" EXACT [] synonym: "regulation of cellular degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044248 ! cellular catabolic process relationship: regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031330 name: negative regulation of cellular catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular catabolic process" EXACT [] synonym: "down-regulation of cellular catabolic process" EXACT [] synonym: "downregulation of cellular catabolic process" EXACT [] synonym: "inhibition of cellular catabolic process" NARROW [] synonym: "negative regulation of cellular breakdown" EXACT [] synonym: "negative regulation of cellular catabolism" EXACT [] synonym: "negative regulation of cellular degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044248 ! cellular catabolic process relationship: negatively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031331 name: positive regulation of cellular catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular catabolic process" NARROW [] synonym: "positive regulation of cellular breakdown" EXACT [] synonym: "positive regulation of cellular catabolism" EXACT [] synonym: "positive regulation of cellular degradation" EXACT [] synonym: "stimulation of cellular catabolic process" NARROW [] synonym: "up regulation of cellular catabolic process" EXACT [] synonym: "up-regulation of cellular catabolic process" EXACT [] synonym: "upregulation of cellular catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044248 ! cellular catabolic process relationship: positively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031333 name: negative regulation of protein-containing complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] synonym: "negative regulation of protein complex assembly" RELATED [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0065003 ! protein-containing complex assembly relationship: negatively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031334 name: positive regulation of protein-containing complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "activation of protein complex assembly" NARROW [] synonym: "positive regulation of protein complex assembly" RELATED [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0065003 ! protein-containing complex assembly relationship: positively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031341 name: regulation of cell killing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001906 ! cell killing relationship: regulates GO:0001906 ! cell killing [Term] id: GO:0031342 name: negative regulation of cell killing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah] synonym: "down regulation of cell killing" EXACT [] synonym: "down-regulation of cell killing" EXACT [] synonym: "downregulation of cell killing" EXACT [] synonym: "inhibition of cell killing" NARROW [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001906 ! cell killing relationship: negatively_regulates GO:0001906 ! cell killing [Term] id: GO:0031343 name: positive regulation of cell killing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah] synonym: "activation of cell killing" NARROW [] synonym: "stimulation of cell killing" NARROW [] synonym: "up regulation of cell killing" EXACT [] synonym: "up-regulation of cell killing" EXACT [] synonym: "upregulation of cell killing" EXACT [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001906 ! cell killing relationship: positively_regulates GO:0001906 ! cell killing [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030030 ! cell projection organization relationship: regulates GO:0030030 ! cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030030 ! cell projection organization relationship: negatively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030030 ! cell projection organization relationship: positively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031347 name: regulation of defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006952 ! defense response relationship: regulates GO:0006952 ! defense response [Term] id: GO:0031348 name: negative regulation of defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah] synonym: "down regulation of defense response" EXACT [] synonym: "down-regulation of defense response" EXACT [] synonym: "downregulation of defense response" EXACT [] synonym: "inhibition of defense response" NARROW [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006952 ! defense response relationship: negatively_regulates GO:0006952 ! defense response [Term] id: GO:0031349 name: positive regulation of defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] synonym: "activation of defense response" NARROW [] synonym: "stimulation of defense response" NARROW [] synonym: "up regulation of defense response" EXACT [] synonym: "up-regulation of defense response" EXACT [] synonym: "upregulation of defense response" EXACT [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006952 ! defense response relationship: positively_regulates GO:0006952 ! defense response [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: goslim_yeast is_a: GO:0032268 ! regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006464 ! cellular protein modification process relationship: regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006464 ! cellular protein modification process relationship: negatively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031401 name: positive regulation of protein modification process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "activation of protein modification" NARROW [] synonym: "stimulation of protein modification" NARROW [] synonym: "up regulation of protein modification" EXACT [] synonym: "up-regulation of protein modification" EXACT [] synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006464 ! cellular protein modification process relationship: positively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0097708 ! intracellular vesicle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031427 name: response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:ef, GOC:mah, ISBN:0198506732] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0008104 ! protein localization [Term] id: GO:0031640 name: killing of cells of other organism namespace: biological_process alt_id: GO:0001908 def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir synonym: "killing of cells of another organism" EXACT [GOC:bf] synonym: "killing of cells of another, non-host, organism" NARROW [] is_a: GO:0001906 ! cell killing [Term] id: GO:0031644 name: regulation of nervous system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurological system process" EXACT [] synonym: "regulation of neurophysiological process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050877 ! nervous system process relationship: regulates GO:0050877 ! nervous system process [Term] id: GO:0031645 name: negative regulation of nervous system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of neurological process" EXACT [] synonym: "down-regulation of neurological process" EXACT [] synonym: "downregulation of neurological process" EXACT [] synonym: "inhibition of neurological process" NARROW [] synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of neurological system process" EXACT [] synonym: "negative regulation of neurophysiological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050877 ! nervous system process relationship: negatively_regulates GO:0050877 ! nervous system process [Term] id: GO:0031646 name: positive regulation of nervous system process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of neurological process" NARROW [] synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of neurological system process" EXACT [] synonym: "positive regulation of neurophysiological process" EXACT [] synonym: "stimulation of neurological process" NARROW [] synonym: "up regulation of neurological process" EXACT [] synonym: "up-regulation of neurological process" EXACT [] synonym: "upregulation of neurological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050877 ! nervous system process relationship: positively_regulates GO:0050877 ! nervous system process [Term] id: GO:0031667 name: response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] is_a: GO:0009991 ! response to extracellular stimulus [Term] id: GO:0031668 name: cellular response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah] is_a: GO:0007154 ! cell communication is_a: GO:0009991 ! response to extracellular stimulus is_a: GO:0051716 ! cellular response to stimulus is_a: GO:0071496 ! cellular response to external stimulus [Term] id: GO:0031669 name: cellular response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0031960 name: response to corticosteroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914] synonym: "response to corticosteroid stimulus" EXACT [GOC:dos] is_a: GO:0048545 ! response to steroid hormone [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: goslim_mouse is_a: GO:0031975 ! envelope relationship: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0031969 name: chloroplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] xref: Wikipedia:Chloroplast_membrane is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0009941 ! chloroplast envelope [Term] id: GO:0031970 name: organelle envelope lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah] synonym: "organelle intermembrane space" EXACT [] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0031975 name: envelope namespace: cellular_component def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0031976 name: plastid thylakoid namespace: cellular_component def: "Any thylakoid within a plastid." [GOC:pz] is_a: GO:0009579 ! thylakoid is_a: GO:0031984 ! organelle subcompartment intersection_of: GO:0009579 ! thylakoid intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009536 ! plastid [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031982 name: vesicle namespace: cellular_component alt_id: GO:0031988 def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031984 name: organelle subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. synonym: "suborganelle compartment" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0031987 name: locomotion involved in locomotory behavior namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] synonym: "locomotion during locomotory behaviour" EXACT [] is_a: GO:0040011 ! locomotion intersection_of: GO:0040011 ! locomotion intersection_of: part_of GO:0007626 ! locomotory behavior relationship: part_of GO:0007626 ! locomotory behavior [Term] id: GO:0032042 name: mitochondrial DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA metabolism" EXACT [] synonym: "mtDNA metabolic process" EXACT [] synonym: "mtDNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process intersection_of: GO:0006259 ! DNA metabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0000002 ! mitochondrial genome maintenance [Term] id: GO:0032060 name: bleb assembly namespace: biological_process def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] synonym: "blebbing" BROAD [GOC:pr] synonym: "cell blebbing" EXACT [] synonym: "membrane blebbing" BROAD [GOC:pr] synonym: "plasma membrane bleb assembly" EXACT [GOC:pr] synonym: "plasma membrane blebbing" EXACT [GOC:pr] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0032091 name: negative regulation of protein binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah] synonym: "down regulation of protein binding" EXACT [] synonym: "down-regulation of protein binding" EXACT [] synonym: "downregulation of protein binding" EXACT [] synonym: "inhibition of protein binding" NARROW [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005515 ! protein binding relationship: negatively_regulates GO:0005515 ! protein binding [Term] id: GO:0032092 name: positive regulation of protein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] synonym: "activation of protein binding" NARROW [] synonym: "stimulation of protein binding" NARROW [] synonym: "up regulation of protein binding" EXACT [] synonym: "up-regulation of protein binding" EXACT [] synonym: "upregulation of protein binding" EXACT [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005515 ! protein binding relationship: positively_regulates GO:0005515 ! protein binding [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009605 ! response to external stimulus relationship: regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009605 ! response to external stimulus relationship: negatively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009605 ! response to external stimulus relationship: positively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032104 name: regulation of response to extracellular stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009991 ! response to extracellular stimulus relationship: regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032105 name: negative regulation of response to extracellular stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] synonym: "down regulation of response to extracellular stimulus" EXACT [] synonym: "down-regulation of response to extracellular stimulus" EXACT [] synonym: "downregulation of response to extracellular stimulus" EXACT [] synonym: "inhibition of response to extracellular stimulus" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009991 ! response to extracellular stimulus relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032106 name: positive regulation of response to extracellular stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah] synonym: "activation of response to extracellular stimulus" NARROW [] synonym: "stimulation of response to extracellular stimulus" NARROW [] synonym: "up regulation of response to extracellular stimulus" EXACT [] synonym: "up-regulation of response to extracellular stimulus" EXACT [] synonym: "upregulation of response to extracellular stimulus" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009991 ! response to extracellular stimulus relationship: positively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032107 name: regulation of response to nutrient levels namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah] is_a: GO:0032104 ! regulation of response to extracellular stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031667 ! response to nutrient levels relationship: regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032108 name: negative regulation of response to nutrient levels namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "down regulation of response to nutrient levels" EXACT [] synonym: "down-regulation of response to nutrient levels" EXACT [] synonym: "downregulation of response to nutrient levels" EXACT [] synonym: "inhibition of response to nutrient levels" NARROW [] is_a: GO:0032105 ! negative regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031667 ! response to nutrient levels relationship: negatively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032109 name: positive regulation of response to nutrient levels namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "activation of response to nutrient levels" NARROW [] synonym: "stimulation of response to nutrient levels" NARROW [] synonym: "up regulation of response to nutrient levels" EXACT [] synonym: "up-regulation of response to nutrient levels" EXACT [] synonym: "upregulation of response to nutrient levels" EXACT [] is_a: GO:0032106 ! positive regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031667 ! response to nutrient levels relationship: positively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] subset: goslim_chembl xref: Wikipedia:Methylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0032268 name: regulation of cellular protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "regulation of cellular protein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044267 ! cellular protein metabolic process relationship: regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032269 name: negative regulation of cellular protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044267 ! cellular protein metabolic process relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032270 name: positive regulation of cellular protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044267 ! cellular protein metabolic process relationship: positively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032279 name: asymmetric synapse namespace: cellular_component def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] synonym: "Gray's type I synapse" EXACT [] is_a: GO:0098984 ! neuron to neuron synapse intersection_of: GO:0098984 ! neuron to neuron synapse intersection_of: has_part GO:0014069 ! postsynaptic density relationship: has_part GO:0014069 ! postsynaptic density [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046907 ! intracellular transport relationship: regulates GO:0046907 ! intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046907 ! intracellular transport relationship: negatively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046907 ! intracellular transport relationship: positively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032409 name: regulation of transporter activity namespace: biological_process def: "Any process that modulates the activity of a transporter." [GOC:mah] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005215 ! transporter activity relationship: regulates GO:0005215 ! transporter activity [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005215 ! transporter activity relationship: negatively_regulates GO:0005215 ! transporter activity [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005215 ! transporter activity relationship: positively_regulates GO:0005215 ! transporter activity [Term] id: GO:0032412 name: regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:0034765 ! regulation of ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015075 ! ion transmembrane transporter activity relationship: regulates GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0032413 name: negative regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "down regulation of ion transporter activity" EXACT [] synonym: "down-regulation of ion transporter activity" EXACT [] synonym: "downregulation of ion transporter activity" EXACT [] synonym: "inhibition of ion transporter activity" NARROW [] synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0034766 ! negative regulation of ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015075 ! ion transmembrane transporter activity relationship: negatively_regulates GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0032414 name: positive regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "activation of ion transporter activity" NARROW [] synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] synonym: "stimulation of ion transporter activity" NARROW [] synonym: "up regulation of ion transporter activity" EXACT [] synonym: "up-regulation of ion transporter activity" EXACT [] synonym: "upregulation of ion transporter activity" EXACT [] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0034767 ! positive regulation of ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015075 ! ion transmembrane transporter activity relationship: positively_regulates GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0032468 name: Golgi calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in Golgi" EXACT [] synonym: "Golgi calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in Golgi" EXACT [] synonym: "regulation of Golgi calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005794 ! Golgi apparatus relationship: occurs_in GO:0005794 ! Golgi apparatus [Term] id: GO:0032469 name: endoplasmic reticulum calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT [] synonym: "calcium ion homeostasis in ER" EXACT [] synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion homeostasis" EXACT [] synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "regulation of calcium ion concentration in ER" EXACT [] synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "regulation of ER calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum relationship: occurs_in GO:0005783 ! endoplasmic reticulum [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process alt_id: GO:0044707 alt_id: GO:0050874 def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] subset: goslim_pir synonym: "organismal physiological process" EXACT [] synonym: "single-multicellular organism process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: RO:0002161 NCBITaxon:4896 property_value: RO:0002161 NCBITaxon:4932 created_by: janelomax creation_date: 2012-09-19T16:07:47Z [Term] id: GO:0032502 name: developmental process namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_aspergillus subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0032504 name: multicellular organism reproduction namespace: biological_process def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] is_a: GO:0000003 ! reproduction is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051668 ! localization within membrane is_a: GO:0061024 ! membrane organization intersection_of: GO:0015031 ! protein transport intersection_of: occurs_in GO:0016020 ! membrane [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: goslim_yeast synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0032814 name: regulation of natural killer cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "regulation of NK cell activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030101 ! natural killer cell activation relationship: regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032815 name: negative regulation of natural killer cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "down regulation of natural killer cell activation" EXACT [] synonym: "down-regulation of natural killer cell activation" EXACT [] synonym: "downregulation of natural killer cell activation" EXACT [] synonym: "inhibition of natural killer cell activation" NARROW [] synonym: "negative regulation of NK cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030101 ! natural killer cell activation relationship: negatively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032816 name: positive regulation of natural killer cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "activation of natural killer cell activation" NARROW [] synonym: "positive regulation of NK cell activation" EXACT [] synonym: "stimulation of natural killer cell activation" NARROW [] synonym: "up regulation of natural killer cell activation" EXACT [] synonym: "up-regulation of natural killer cell activation" EXACT [] synonym: "upregulation of natural killer cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030101 ! natural killer cell activation relationship: positively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032838 name: plasma membrane bounded cell projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051179 ! localization relationship: regulates GO:0051179 ! localization [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008104 ! protein localization relationship: regulates GO:0008104 ! protein localization [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007017 ! microtubule-based process relationship: regulates GO:0007017 ! microtubule-based process [Term] id: GO:0032887 name: regulation of spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:mah] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0090224 ! regulation of spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051231 ! spindle elongation relationship: regulates GO:0051231 ! spindle elongation [Term] id: GO:0032888 name: regulation of mitotic spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah] is_a: GO:0032887 ! regulation of spindle elongation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0060236 ! regulation of mitotic spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000022 ! mitotic spindle elongation relationship: regulates GO:0000022 ! mitotic spindle elongation [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015849 ! organic acid transport relationship: regulates GO:0015849 ! organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015849 ! organic acid transport relationship: negatively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015849 ! organic acid transport relationship: positively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0046903 ! secretion is_a: GO:0140352 ! export from cell [Term] id: GO:0032989 name: cellular component morphogenesis namespace: biological_process def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0016043 ! cellular component organization is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component [Term] id: GO:0033013 name: tetrapyrrole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] synonym: "tetrapyrrole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006996 ! organelle organization relationship: regulates GO:0006996 ! organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051276 ! chromosome organization relationship: regulates GO:0051276 ! chromosome organization [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000819 ! sister chromatid segregation relationship: regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000819 ! sister chromatid segregation relationship: negatively_regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0033045 ! regulation of sister chromatid segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000070 ! mitotic sister chromatid segregation relationship: regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0045839 ! negative regulation of mitotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033142 name: progesterone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a progesterone receptor." [GOC:mah] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006886 ! intracellular protein transport relationship: regulates GO:0006886 ! intracellular protein transport [Term] id: GO:0033273 name: response to vitamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl] is_a: GO:0007584 ! response to nutrient [Term] id: GO:0033363 name: secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "secretory granule organisation" EXACT [GOC:mah] synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0033371 name: T cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "T cell secretory granule organisation" EXACT [GOC:mah] synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah] synonym: "T lymphocyte secretory granule organization" EXACT [] synonym: "T-cell secretory granule organization" EXACT [] synonym: "T-lymphocyte secretory granule maturation" RELATED [] synonym: "T-lymphocyte secretory granule organization" EXACT [] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0033500 name: carbohydrate homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0033576 name: protein glycosylation in cytosol namespace: biological_process def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol." [GOC:mah, GOC:pr, PMID:12042244] synonym: "protein amino acid glycosylation in cytosol" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005829 ! cytosol relationship: occurs_in GO:0005829 ! cytosol [Term] id: GO:0033577 name: protein glycosylation in endoplasmic reticulum namespace: biological_process def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, GOC:pr, PMID:12042244] synonym: "core glycosylation" RELATED [PMID:6345657] synonym: "protein amino acid glycosylation in endoplasmic reticulum" EXACT [GOC:bf] synonym: "protein amino acid glycosylation in ER" EXACT [] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum relationship: occurs_in GO:0005783 ! endoplasmic reticulum [Term] id: GO:0033578 name: protein glycosylation in Golgi namespace: biological_process def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, GOC:pr, PMID:12042244] synonym: "protein amino acid glycosylation in Golgi" EXACT [GOC:bf] synonym: "terminal glycosylation" NARROW [PMID:6345657] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005794 ! Golgi apparatus relationship: occurs_in GO:0005794 ! Golgi apparatus [Term] id: GO:0033635 name: modulation by symbiont of host response to abiotic stimulus namespace: biological_process def: "Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044003 ! modulation by symbiont of host process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0009628 ! response to abiotic stimulus relationship: regulates GO:0009628 ! response to abiotic stimulus [Term] id: GO:0033636 name: modulation by symbiont of host response to temperature stimulus namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "modulation by symbiont of host response to thermal stimulus" EXACT [] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0009266 ! response to temperature stimulus relationship: regulates GO:0009266 ! response to temperature stimulus [Term] id: GO:0033640 name: modulation by symbiont of host response to osmotic stress namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus is_a: GO:0047484 ! regulation of response to osmotic stress intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0006970 ! response to osmotic stress [Term] id: GO:0033641 name: modulation by symbiont of host response to pH namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0009268 ! response to pH relationship: regulates GO:0009268 ! response to pH [Term] id: GO:0033643 name: host cell part namespace: cellular_component def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0018995 ! host cellular component intersection_of: GO:0018995 ! host cellular component intersection_of: part_of GO:0043657 ! host cell relationship: part_of GO:0043657 ! host cell [Term] id: GO:0033646 name: host intracellular part namespace: cellular_component def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "host cell intracellular part" EXACT [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0043656 ! host intracellular region [Term] id: GO:0033647 name: host intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033646 ! host intracellular part [Term] id: GO:0033648 name: host intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0033647 ! host intracellular organelle [Term] id: GO:0033668 name: negative regulation by symbiont of host apoptotic process namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'. synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "inhibition by organism of host apoptotic programmed cell death" NARROW [] synonym: "negative regulation by symbiont of host apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death is_a: GO:0052150 ! modulation by symbiont of host apoptotic process intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: negatively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0033673 name: negative regulation of kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "down regulation of kinase activity" EXACT [] synonym: "down-regulation of kinase activity" EXACT [] synonym: "downregulation of kinase activity" EXACT [] synonym: "inhibition of kinase activity" NARROW [] synonym: "kinase inhibitor" NARROW [] is_a: GO:0042326 ! negative regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051348 ! negative regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016301 ! kinase activity relationship: negatively_regulates GO:0016301 ! kinase activity [Term] id: GO:0033674 name: positive regulation of kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "kinase activator" NARROW [] synonym: "stimulation of kinase activity" NARROW [] synonym: "up regulation of kinase activity" EXACT [] synonym: "up-regulation of kinase activity" EXACT [] synonym: "upregulation of kinase activity" EXACT [] is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051347 ! positive regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016301 ! kinase activity relationship: positively_regulates GO:0016301 ! kinase activity [Term] id: GO:0033993 name: response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0034097 name: response to cytokine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] synonym: "response to cytokine stimulus" EXACT [GOC:dos] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0034101 name: erythrocyte homeostasis namespace: biological_process def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] synonym: "RBC homeostasis" EXACT [CL:0000232] synonym: "red blood cell homeostasis" EXACT [CL:0000232] is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0034109 name: homotypic cell-cell adhesion namespace: biological_process def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms. is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0034110 name: regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034109 ! homotypic cell-cell adhesion relationship: regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034111 name: negative regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034112 name: positive regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034109 ! homotypic cell-cell adhesion relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034220 name: ion transmembrane transport namespace: biological_process alt_id: GO:0099131 def: "A process in which an ion is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW [] synonym: "ion membrane transport" EXACT [] synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0006811 ! ion transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034248 name: regulation of cellular amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043603 ! cellular amide metabolic process relationship: regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034249 name: negative regulation of cellular amide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "negative regulation of amide metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043603 ! cellular amide metabolic process relationship: negatively_regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034250 name: positive regulation of cellular amide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "positive regulation of amide metabolism" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043603 ! cellular amide metabolic process relationship: positively_regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034404 name: nucleobase-containing small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah] synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT [] synonym: "nucleobase, nucleoside and nucleotide formation" EXACT [] synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT [] is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0034613 name: cellular protein localization namespace: biological_process alt_id: GO:0016249 def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] subset: goslim_drosophila synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "channel localizer activity" NARROW [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cellular nitrogen compound metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034644 name: cellular response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] synonym: "cellular response to ultraviolet light stimulus" EXACT [] synonym: "cellular response to ultraviolet radiation stimulus" EXACT [] synonym: "cellular response to UV light stimulus" EXACT [] synonym: "cellular response to UV radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV is_a: GO:0071482 ! cellular response to light stimulus [Term] id: GO:0034645 name: cellular macromolecule biosynthetic process namespace: biological_process alt_id: GO:0034961 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [GOC:mah] synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule anabolism" EXACT [GOC:mah] synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah] synonym: "cellular macromolecule formation" EXACT [GOC:mah] synonym: "cellular macromolecule synthesis" EXACT [GOC:mah] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0034762 name: regulation of transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "regulation of membrane transport" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0055085 ! transmembrane transport relationship: regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034763 name: negative regulation of transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane transport" EXACT [] synonym: "down-regulation of transmembrane transport" EXACT [] synonym: "downregulation of transmembrane transport" EXACT [] synonym: "inhibition of transmembrane transport" NARROW [] synonym: "negative regulation of membrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0055085 ! transmembrane transport relationship: negatively_regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034764 name: positive regulation of transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane transport" NARROW [] synonym: "positive regulation of membrane transport" EXACT [] synonym: "stimulation of transmembrane transport" NARROW [] synonym: "up regulation of transmembrane transport" EXACT [] synonym: "up-regulation of transmembrane transport" EXACT [] synonym: "upregulation of transmembrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0055085 ! transmembrane transport relationship: positively_regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034765 name: regulation of ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "regulation of ion membrane transport" EXACT [] synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034220 ! ion transmembrane transport relationship: regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034766 name: negative regulation of ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane ion transport" EXACT [] synonym: "down-regulation of transmembrane ion transport" EXACT [] synonym: "downregulation of transmembrane ion transport" EXACT [] synonym: "inhibition of transmembrane ion transport" NARROW [] synonym: "negative regulation of ion membrane transport" EXACT [] synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0043271 ! negative regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034220 ! ion transmembrane transport relationship: negatively_regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034767 name: positive regulation of ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane ion transport" NARROW [] synonym: "positive regulation of ion membrane transport" EXACT [] synonym: "positive regulation of transmembrane ion transport" EXACT [] synonym: "stimulation of transmembrane ion transport" NARROW [] synonym: "up regulation of transmembrane ion transport" EXACT [] synonym: "up-regulation of transmembrane ion transport" EXACT [] synonym: "upregulation of transmembrane ion transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0043270 ! positive regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034220 ! ion transmembrane transport relationship: positively_regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0035082 name: axoneme assembly namespace: biological_process alt_id: GO:0035083 alt_id: GO:0035084 def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "axoneme biogenesis" RELATED [GOC:mah] synonym: "ciliary axoneme assembly" EXACT [] synonym: "cilium axoneme assembly" EXACT [] synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] synonym: "flagellar axoneme assembly" EXACT [] synonym: "flagellum axoneme assembly" EXACT [] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0060271 ! cilium assembly [Term] id: GO:0035106 name: operant conditioning namespace: biological_process def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373] synonym: "instrumental conditioning" EXACT [] xref: Wikipedia:Operant_conditioning is_a: GO:0007612 ! learning [Term] id: GO:0035176 name: social behavior namespace: biological_process def: "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior] comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. synonym: "cooperative behavior" RELATED [] synonym: "social behaviour" EXACT [] xref: Wikipedia:Social_behavior is_a: GO:0007610 ! behavior is_a: GO:0051703 ! intraspecies interaction between organisms [Term] id: GO:0035194 name: posttranscriptional gene silencing by RNA namespace: biological_process def: "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger RNA (often mRNA) degradation or negatively regulate mRNA translation." [GOC:aruk, GOC:bc, GOC:mah, GOC:rl, PMID:15020054, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604] synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] synonym: "sense-PTGS" RELATED [] is_a: GO:0016441 ! posttranscriptional gene silencing is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0035239 name: tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035295 ! tube development [Term] id: GO:0035257 name: nuclear hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf] is_a: GO:0051427 ! hormone receptor binding is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0035258 name: steroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid hormone receptor." [GOC:bf] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0035264 name: multicellular organism growth namespace: biological_process def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] synonym: "body growth" RELATED [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth [Term] id: GO:0035295 name: tube development namespace: biological_process def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0035456 name: response to interferon-beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374, PR:000008924] synonym: "response to beta-1 interferon" RELATED [GOC:sl] synonym: "response to fiblaferon" EXACT [GOC:sl] synonym: "response to fibroblast interferon" EXACT [GOC:sl] synonym: "response to interferon beta" EXACT [GOC:hp, PR:000008924] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2010-04-16T11:06:12Z [Term] id: GO:0035461 name: vitamin transmembrane transport namespace: biological_process def: "The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vitamin membrane transport" EXACT [] is_a: GO:0051180 ! vitamin transport is_a: GO:0055085 ! transmembrane transport created_by: rfoulger creation_date: 2010-04-19T10:21:41Z [Term] id: GO:0035470 name: positive regulation of vascular wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:rph] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:0061043 ! regulation of vascular wound healing is_a: GO:0090303 ! positive regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061042 ! vascular wound healing relationship: positively_regulates GO:0061042 ! vascular wound healing created_by: rfoulger creation_date: 2010-04-22T10:49:09Z [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process alt_id: GO:0007242 alt_id: GO:0007243 alt_id: GO:0023013 alt_id: GO:0023034 def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] subset: goslim_drosophila synonym: "intracellular protein kinase cascade" NARROW [GOC:signaling] synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" RELATED [GOC:signaling] synonym: "intracellular signaling chain" EXACT [ISBN:3527303782] synonym: "intracellular signaling pathway" RELATED [] synonym: "protein kinase cascade" NARROW [GOC:signaling] synonym: "signal transduction via intracellular signaling cascade" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular created_by: rfoulger creation_date: 2010-05-14T01:14:37Z [Term] id: GO:0035592 name: establishment of protein localization to extracellular region namespace: biological_process def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] synonym: "establishment of protein localization in extracellular region" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071692 ! protein localization to extracellular region created_by: rfoulger creation_date: 2010-11-09T10:25:08Z [Term] id: GO:0035735 name: intraciliary transport involved in cilium assembly namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia, Reactome:R-HSA-5620924.2] synonym: "intraciliary transport involved in cilium morphogenesis" RELATED [] synonym: "intraflagellar transport" BROAD [] synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED [] xref: Reactome:R-HSA-5620924.2 is_a: GO:0042073 ! intraciliary transport intersection_of: GO:0042073 ! intraciliary transport intersection_of: part_of GO:0060271 ! cilium assembly relationship: part_of GO:0060271 ! cilium assembly created_by: rfoulger creation_date: 2011-03-17T10:55:42Z [Term] id: GO:0035821 name: modulation of process of other organism namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of another organism." [GOC:bf] synonym: "modification of morphology or physiology of other organism" EXACT [] synonym: "regulation of morphology of other organism" NARROW [GOC:bf] synonym: "regulation of morphology or physiology of other organism" RELATED [GOC:bf] synonym: "regulation of physiological process of other organism" NARROW [GOC:bf] synonym: "regulation of physiology of other organism" NARROW [GOC:bf] is_a: GO:0044419 ! interspecies interaction between organisms property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18605 xsd:anyURI created_by: rfoulger creation_date: 2011-04-21T01:31:51Z [Term] id: GO:0035940 name: negative regulation of peptidase activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism." [GOC:klp, PMID:10595640] synonym: "down regulation of peptidase activity in other organism" EXACT [GOC:bf] synonym: "down-regulation of protease activity in other organism" NARROW [GOC:bf] synonym: "downregulation of peptidase activity in other organism" EXACT [GOC:bf] synonym: "inhibition of protease activity in other organism" NARROW [GOC:bf] synonym: "negative regulation of protease activity in other organism" NARROW [GOC:bf] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0044362 ! negative regulation of molecular function in other organism created_by: rfoulger creation_date: 2011-07-22T02:59:40Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification created_by: rfoulger creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0036270 name: response to diuretic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042493 ! response to drug created_by: rfoulger creation_date: 2012-07-09T01:26:24Z [Term] id: GO:0036271 name: response to methylphenidate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus." [GOC:hp, Wikipedia:Methylphenidate] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to MPD" EXACT [CHEBI:6887] synonym: "response to MPH" EXACT [CHEBI:6887] synonym: "response to ritalin" EXACT [CHEBI:6887] is_a: GO:0042493 ! response to drug is_a: GO:1901698 ! response to nitrogen compound created_by: rfoulger creation_date: 2012-07-09T01:30:57Z [Term] id: GO:0036272 name: response to gemcitabine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas." [GOC:hp, Wikipedia:Gemcitabine] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901] synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-09T01:36:03Z [Term] id: GO:0036273 name: response to statin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664] synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664] is_a: GO:0010033 ! response to organic substance is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-09T01:54:01Z [Term] id: GO:0036274 name: response to lapatinib namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-09T02:02:26Z [Term] id: GO:0036275 name: response to 5-fluorouracil namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345] synonym: "response to fluorouracil" EXACT [GOC:hp] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite created_by: rfoulger creation_date: 2012-07-09T02:08:23Z [Term] id: GO:0036276 name: response to antidepressant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042493 ! response to drug created_by: rfoulger creation_date: 2012-07-09T02:12:44Z [Term] id: GO:0036277 name: response to anticonvulsant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042493 ! response to drug created_by: rfoulger creation_date: 2012-07-09T02:40:12Z [Term] id: GO:0036287 name: response to iloperidone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0071867 ! response to monoamine is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901654 ! response to ketone created_by: rfoulger creation_date: 2012-07-16T05:01:29Z [Term] id: GO:0036288 name: response to ximelagatran namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-16T05:03:56Z [Term] id: GO:0036385 name: nucleoid DNA packaging namespace: biological_process def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid." [GOC:bf, GOC:bhm] is_a: GO:0006323 ! DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0009295 ! nucleoid relationship: occurs_in GO:0009295 ! nucleoid created_by: rfoulger creation_date: 2013-05-30T10:36:05Z [Term] id: GO:0036386 name: bacterial nucleoid DNA packaging namespace: biological_process def: "Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling." [GOC:bf, GOC:bhm, PMID:17097674, PMID:17360520] synonym: "chromosomal compaction" BROAD [PMID:17097674] synonym: "nucleoid compaction" BROAD [PMID:17097674] synonym: "prokaryotic DNA condensation" BROAD [Wikipedia:DNA_condensation] is_a: GO:0036385 ! nucleoid DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0043590 ! bacterial nucleoid relationship: occurs_in GO:0043590 ! bacterial nucleoid created_by: rfoulger creation_date: 2013-05-30T10:41:08Z [Term] id: GO:0038023 name: signaling receptor activity namespace: molecular_function alt_id: GO:0004872 alt_id: GO:0019041 def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] is_a: GO:0060089 ! molecular transducer activity created_by: rfoulger creation_date: 2011-08-01T02:45:27Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0040007 ! growth relationship: regulates GO:0040007 ! growth [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_generic subset: goslim_pir is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: RO:0002161 NCBITaxon:451864 [Term] id: GO:0040012 name: regulation of locomotion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0040011 ! locomotion relationship: regulates GO:0040011 ! locomotion [Term] id: GO:0040013 name: negative regulation of locomotion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "down regulation of locomotion" EXACT [] synonym: "down-regulation of locomotion" EXACT [] synonym: "downregulation of locomotion" EXACT [] synonym: "inhibition of locomotion" NARROW [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0040011 ! locomotion relationship: negatively_regulates GO:0040011 ! locomotion [Term] id: GO:0040014 name: regulation of multicellular organism growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035264 ! multicellular organism growth relationship: regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040015 name: negative regulation of multicellular organism growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035264 ! multicellular organism growth relationship: negatively_regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040016 name: embryonic cleavage namespace: biological_process def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] is_a: GO:0051301 ! cell division relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0040017 name: positive regulation of locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "activation of locomotion" NARROW [] synonym: "stimulation of locomotion" NARROW [] synonym: "up regulation of locomotion" EXACT [] synonym: "up-regulation of locomotion" EXACT [] synonym: "upregulation of locomotion" EXACT [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0040011 ! locomotion relationship: positively_regulates GO:0040011 ! locomotion [Term] id: GO:0040018 name: positive regulation of multicellular organism growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035264 ! multicellular organism growth relationship: positively_regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040019 name: positive regulation of embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "activation of embryonic development" NARROW [] synonym: "stimulation of embryonic development" NARROW [] synonym: "up regulation of embryonic development" EXACT [] synonym: "up-regulation of embryonic development" EXACT [] synonym: "upregulation of embryonic development" EXACT [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009790 ! embryo development relationship: positively_regulates GO:0009790 ! embryo development [Term] id: GO:0040020 name: regulation of meiotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] synonym: "regulation of meiosis" BROAD [GOC:vw] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140013 ! meiotic nuclear division relationship: regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0040029 name: regulation of gene expression, epigenetic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582] subset: goslim_plant is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0042025 name: host cell nucleus namespace: cellular_component alt_id: GO:0033649 def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033648 ! host intracellular membrane-bounded organelle [Term] id: GO:0042048 name: olfactory behavior namespace: biological_process def: "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] synonym: "behavioral response to scent" EXACT [] synonym: "behavioral response to smell" EXACT [] synonym: "behavioural response to odour" EXACT [] synonym: "behavioural response to scent" EXACT [] synonym: "behavioural response to smell" EXACT [] synonym: "olfactory behaviour" EXACT [] is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0042060 name: wound healing namespace: biological_process def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] xref: Wikipedia:Wound_healing is_a: GO:0009611 ! response to wounding [Term] id: GO:0042073 name: intraciliary transport namespace: biological_process alt_id: GO:0035734 def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "IFT" RELATED [] synonym: "intraflagellar transport" EXACT [] synonym: "intraflagellar transport involved in cilium organization" EXACT [] synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT [] xref: Wikipedia:Intraflagellar_transport is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0098840 ! protein transport along microtubule relationship: occurs_in GO:0005929 ! cilium relationship: part_of GO:0044782 ! cilium organization property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0042078 name: germ-line stem cell division namespace: biological_process alt_id: GO:0048131 def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] synonym: "germ-line stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0042116 name: macrophage activation namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301] synonym: "macrophage polarization" EXACT [] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0042127 name: regulation of cell population proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] synonym: "regulation of cell proliferation" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008283 ! cell population proliferation relationship: regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0042170 name: plastid membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0042214 name: terpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [GOC:curators] synonym: "terpene metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0042278 name: purine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "purine metabolic process" BROAD [] synonym: "purine metabolism" BROAD [] synonym: "purine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0042320 name: regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998] synonym: "regulation of REM sleep" EXACT [] is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0042321 name: negative regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981] synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW [] synonym: "negative regulation of sleep" EXACT [] is_a: GO:0042754 ! negative regulation of circadian rhythm is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042322 name: negative regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl] synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "negative regulation of REM sleep" EXACT [] is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0042323 name: negative regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl] synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "negative regulation of non-REM sleep" EXACT [] is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016310 ! phosphorylation relationship: regulates GO:0016310 ! phosphorylation [Term] id: GO:0042326 name: negative regulation of phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] synonym: "down regulation of phosphorylation" EXACT [] synonym: "down-regulation of phosphorylation" EXACT [] synonym: "downregulation of phosphorylation" EXACT [] synonym: "inhibition of phosphorylation" NARROW [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016310 ! phosphorylation relationship: negatively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042327 name: positive regulation of phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] synonym: "activation of phosphorylation" NARROW [] synonym: "stimulation of phosphorylation" NARROW [] synonym: "up regulation of phosphorylation" EXACT [] synonym: "up-regulation of phosphorylation" EXACT [] synonym: "upregulation of phosphorylation" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016310 ! phosphorylation relationship: positively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042330 name: taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] synonym: "directed movement in response to stimulus" EXACT [] xref: Wikipedia:Taxis is_a: GO:0040011 ! locomotion relationship: part_of GO:0009605 ! response to external stimulus [Term] id: GO:0042331 name: phototaxis namespace: biological_process alt_id: GO:0046953 def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] synonym: "phototactic behavior" EXACT [] synonym: "phototactic behaviour" EXACT [] synonym: "taxis in response to light" EXACT [] xref: Wikipedia:Phototaxis is_a: GO:0009416 ! response to light stimulus is_a: GO:0009453 ! energy taxis [Term] id: GO:0042360 name: vitamin E metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732] synonym: "alpha-tocopherol metabolic process" NARROW [] synonym: "alpha-tocopherol metabolism" NARROW [] synonym: "tocopherol metabolic process" EXACT [] synonym: "tocopherol metabolism" EXACT [] synonym: "vitamin E metabolism" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042451 name: purine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] synonym: "purine nucleoside anabolism" EXACT [] synonym: "purine nucleoside biosynthesis" EXACT [] synonym: "purine nucleoside formation" EXACT [] synonym: "purine nucleoside synthesis" EXACT [] is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0042278 ! purine nucleoside metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0042455 name: ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] synonym: "ribonucleoside anabolism" EXACT [] synonym: "ribonucleoside biosynthesis" EXACT [] synonym: "ribonucleoside formation" EXACT [] synonym: "ribonucleoside synthesis" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process [Term] id: GO:0042476 name: odontogenesis namespace: biological_process alt_id: GO:0042477 def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah] synonym: "odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "odontogeny" EXACT [] synonym: "odontosis" EXACT [] synonym: "tooth development" RELATED [] synonym: "tooth morphogenesis" EXACT [] xref: Wikipedia:Odontogenesis is_a: GO:0009887 ! animal organ morphogenesis property_value: RO:0002161 NCBITaxon:8782 [Term] id: GO:0042481 name: regulation of odontogenesis namespace: biological_process alt_id: GO:0042484 def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "regulation of tooth development" EXACT [] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042476 ! odontogenesis relationship: regulates GO:0042476 ! odontogenesis [Term] id: GO:0042482 name: positive regulation of odontogenesis namespace: biological_process alt_id: GO:0042485 def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "activation of odontogenesis" NARROW [] synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "positive regulation of tooth development" EXACT [] synonym: "stimulation of odontogenesis" NARROW [] synonym: "up regulation of odontogenesis" EXACT [] synonym: "up-regulation of odontogenesis" EXACT [] synonym: "upregulation of odontogenesis" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042476 ! odontogenesis relationship: positively_regulates GO:0042476 ! odontogenesis [Term] id: GO:0042483 name: negative regulation of odontogenesis namespace: biological_process alt_id: GO:0042486 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "down regulation of odontogenesis" EXACT [] synonym: "down-regulation of odontogenesis" EXACT [] synonym: "downregulation of odontogenesis" EXACT [] synonym: "inhibition of odontogenesis" NARROW [] synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "negative regulation of tooth development" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042476 ! odontogenesis relationship: negatively_regulates GO:0042476 ! odontogenesis [Term] id: GO:0042493 name: response to drug namespace: biological_process alt_id: GO:0017035 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl] subset: goslim_candida synonym: "drug resistance" RELATED [] synonym: "drug susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0042538 name: hyperosmotic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to hyperosmotic salt stress" EXACT [] synonym: "salt tolerance" RELATED [] is_a: GO:0006972 ! hyperosmotic response is_a: GO:0009651 ! response to salt stress [Term] id: GO:0042551 name: neuron maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0042558 name: pteridine-containing compound metabolic process namespace: biological_process alt_id: GO:0019721 def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] synonym: "pteridine and derivative metabolic process" EXACT [] synonym: "pteridine and derivative metabolism" EXACT [] synonym: "pteridine-containing compound metabolism" EXACT [] synonym: "pterin metabolic process" NARROW [] synonym: "pterin metabolism" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0042592 name: homeostatic process namespace: biological_process alt_id: GO:0032844 alt_id: GO:0032845 alt_id: GO:0032846 def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse synonym: "activation of homeostatic process" NARROW [] synonym: "homeostasis" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] synonym: "negative regulation of homeostatic process" RELATED [] synonym: "positive regulation of homeostatic process" RELATED [] synonym: "regulation of homeostatic process" RELATED [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0042593 name: glucose homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] is_a: GO:0033500 ! carbohydrate homeostasis [Term] id: GO:0042594 name: response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] subset: goslim_yeast is_a: GO:0006950 ! response to stress is_a: GO:0031667 ! response to nutrient levels [Term] id: GO:0042630 name: behavioral response to water deprivation namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of deprivation of water." [GOC:jl] synonym: "behavioral response to drought" EXACT [] synonym: "behavioral response to thirst" EXACT [] synonym: "behavioural response to water deprivation" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0009414 ! response to water deprivation [Term] id: GO:0042644 name: chloroplast nucleoid namespace: cellular_component def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0042645 name: mitochondrial nucleoid namespace: cellular_component def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0042646 name: plastid nucleoid namespace: cellular_component def: "The region of a plastid to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0042647 name: proplastid nucleoid namespace: cellular_component def: "The region of a proplastid to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0009537 ! proplastid relationship: part_of GO:0009571 ! proplastid stroma [Term] id: GO:0042710 name: biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229] subset: gocheck_do_not_annotate subset: gocheck_do_not_manually_annotate subset: goslim_candida subset: goslim_pir is_a: GO:0098630 ! aggregation of unicellular organisms property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17727 xsd:anyURI [Term] id: GO:0042723 name: thiamine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it." [GOC:jl] synonym: "thiamin and derivative metabolic process" EXACT [] synonym: "thiamin and derivative metabolism" EXACT [] synonym: "thiamin-containing compound metabolic process" EXACT [] synonym: "thiamine and derivative metabolic process" EXACT [] synonym: "thiamine and derivative metabolism" EXACT [] synonym: "thiamine-containing compound metabolism" EXACT [] synonym: "vitamin B1 and derivative metabolic process" EXACT [] synonym: "vitamin B1 and derivative metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0042745 name: circadian sleep/wake cycle namespace: biological_process def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com] is_a: GO:0048512 ! circadian behavior [Term] id: GO:0042747 name: circadian sleep/wake cycle, REM sleep namespace: biological_process def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172] is_a: GO:0022410 ! circadian sleep/wake cycle process relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042748 name: circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com] is_a: GO:0022410 ! circadian sleep/wake cycle process relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042749 name: regulation of circadian sleep/wake cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0050795 ! regulation of behavior is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042745 ! circadian sleep/wake cycle relationship: regulates GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0042752 name: regulation of circadian rhythm namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007623 ! circadian rhythm relationship: regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042753 name: positive regulation of circadian rhythm namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] synonym: "activation of circadian rhythm" NARROW [] synonym: "stimulation of circadian rhythm" NARROW [] synonym: "up regulation of circadian rhythm" EXACT [] synonym: "up-regulation of circadian rhythm" EXACT [] synonym: "upregulation of circadian rhythm" EXACT [] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007623 ! circadian rhythm relationship: positively_regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042754 name: negative regulation of circadian rhythm namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] synonym: "down regulation of circadian rhythm" EXACT [] synonym: "down-regulation of circadian rhythm" EXACT [] synonym: "downregulation of circadian rhythm" EXACT [] synonym: "inhibition of circadian rhythm" NARROW [] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007623 ! circadian rhythm relationship: negatively_regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042755 name: eating behavior namespace: biological_process def: "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, GOC:pr, PMID:19361967] synonym: "eating behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior [Term] id: GO:0042756 name: drinking behavior namespace: biological_process def: "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr] synonym: "drinking behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior [Term] id: GO:0042762 name: regulation of sulfur metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators] synonym: "regulation of sulfur metabolism" EXACT [] synonym: "regulation of sulphur metabolic process" EXACT [] synonym: "regulation of sulphur metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006790 ! sulfur compound metabolic process relationship: regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0042887 name: amide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] synonym: "amine/amide/polyamine channel activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0042886 ! amide transport [Term] id: GO:0042908 name: xenobiotic transport namespace: biological_process def: "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0042910 name: xenobiotic transmembrane transporter activity namespace: molecular_function alt_id: GO:0015238 alt_id: GO:0015239 alt_id: GO:0015559 alt_id: GO:0015564 alt_id: GO:0090484 def: "Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators] subset: goslim_metagenomics synonym: "drug transmembrane transporter activity" RELATED [] synonym: "drug transporter activity" RELATED [] synonym: "multidrug efflux pump activity" RELATED [] synonym: "multidrug transporter activity" RELATED [] synonym: "multidrug, alkane resistant pump activity" RELATED [] synonym: "xenobiotic transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0042908 ! xenobiotic transport [Term] id: GO:0042981 name: regulation of apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "apoptosis regulator activity" RELATED [] synonym: "regulation of apoptosis" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006915 ! apoptotic process relationship: regulates GO:0006915 ! apoptotic process [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0044464 ! obsolete cell part is_a: GO:0110165 ! cellular anatomical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043005 name: neuron projection namespace: cellular_component def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_pir synonym: "nerve fiber" RELATED [GOC:dph] synonym: "neurite" NARROW [] synonym: "neuron process" EXACT [] synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889] synonym: "neuronal cell projection" EXACT [] xref: NIF_Subcellular:sao867568886 is_a: GO:0120025 ! plasma membrane bounded cell projection property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043030 name: regulation of macrophage activation namespace: biological_process def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl] synonym: "regulation of macrophage polarization" EXACT [] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042116 ! macrophage activation relationship: regulates GO:0042116 ! macrophage activation [Term] id: GO:0043031 name: negative regulation of macrophage activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl] synonym: "down regulation of macrophage activation" EXACT [] synonym: "down-regulation of macrophage activation" EXACT [] synonym: "downregulation of macrophage activation" EXACT [] synonym: "inhibition of macrophage activation" NARROW [] synonym: "negative regulation of macrophage polarization" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042116 ! macrophage activation relationship: negatively_regulates GO:0042116 ! macrophage activation [Term] id: GO:0043032 name: positive regulation of macrophage activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl] synonym: "activation of macrophage activation" NARROW [] synonym: "positive regulation of macrophage polarization" EXACT [] synonym: "stimulation of macrophage activation" NARROW [] synonym: "up regulation of macrophage activation" EXACT [] synonym: "up-regulation of macrophage activation" EXACT [] synonym: "upregulation of macrophage activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042116 ! macrophage activation relationship: positively_regulates GO:0042116 ! macrophage activation [Term] id: GO:0043045 name: DNA methylation involved in embryo development namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111] synonym: "de novo DNA methylation" RELATED [] is_a: GO:0006306 ! DNA methylation is_a: GO:1901538 ! changes to DNA methylation involved in embryo development intersection_of: GO:0006306 ! DNA methylation intersection_of: part_of GO:0009790 ! embryo development [Term] id: GO:0043046 name: DNA methylation involved in gamete generation namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete." [GOC:go_curators, PMID:12138111] synonym: "de novo DNA methylation" RELATED [] is_a: GO:0006306 ! DNA methylation is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism intersection_of: GO:0006306 ! DNA methylation intersection_of: part_of GO:0007276 ! gamete generation relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0043062 name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "extracellular structure organisation" EXACT [] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043068 ! positive regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006915 ! apoptotic process relationship: positively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0043066 name: negative regulation of apoptotic process namespace: biological_process alt_id: GO:0006916 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "anti-apoptosis" EXACT [] synonym: "apoptosis inhibitor activity" RELATED [] synonym: "down regulation of apoptosis" EXACT [] synonym: "down-regulation of apoptosis" EXACT [] synonym: "downregulation of apoptosis" EXACT [] synonym: "inhibition of apoptosis" NARROW [] synonym: "negative regulation of apoptosis" NARROW [] synonym: "pro-survival" RELATED [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043069 ! negative regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006915 ! apoptotic process relationship: negatively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0043067 name: regulation of programmed cell death namespace: biological_process alt_id: GO:0043070 def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0010941 ! regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0012501 ! programmed cell death relationship: regulates GO:0012501 ! programmed cell death [Term] id: GO:0043068 name: positive regulation of programmed cell death namespace: biological_process alt_id: GO:0043071 def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "activation of programmed cell death" NARROW [] synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] synonym: "stimulation of programmed cell death" NARROW [] synonym: "up regulation of programmed cell death" EXACT [] synonym: "up-regulation of programmed cell death" EXACT [] synonym: "upregulation of programmed cell death" EXACT [] is_a: GO:0010942 ! positive regulation of cell death is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0012501 ! programmed cell death relationship: positively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043069 name: negative regulation of programmed cell death namespace: biological_process alt_id: GO:0043072 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "down regulation of programmed cell death" EXACT [] synonym: "down-regulation of programmed cell death" EXACT [] synonym: "downregulation of programmed cell death" EXACT [] synonym: "inhibition of programmed cell death" NARROW [] synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0060548 ! negative regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0012501 ! programmed cell death relationship: negatively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process alt_id: GO:0048554 def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: goslim_chembl synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] xref: MIPS_funcat:18.02.01.01 is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003824 ! catalytic activity relationship: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process alt_id: GO:0048553 def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] synonym: "down regulation of enzyme activity" EXACT [] synonym: "down regulation of metalloenzyme activity" NARROW [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "down-regulation of metalloenzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "downregulation of metalloenzyme activity" NARROW [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "inhibition of metalloenzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] synonym: "negative regulation of metalloenzyme activity" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003824 ! catalytic activity relationship: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0043283 alt_id: GO:0044259 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] synonym: "multicellular organismal macromolecule metabolic process" NARROW [] synonym: "organismal macromolecule metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0043207 name: response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043209 name: myelin sheath namespace: cellular_component def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin] synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204] synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730] synonym: "Schwann cell myelin sheath" NARROW [] xref: FMA:62983 xref: NIF_Subcellular:sao593830697 xref: Wikipedia:Myelin is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle [Term] id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005622 ! intracellular relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0043230 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005576 ! extracellular region relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_mouse subset: goslim_pir synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0005622 ! intracellular [Term] id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] is_a: GO:0031974 ! membrane-enclosed lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0043254 name: regulation of protein-containing complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] synonym: "regulation of protein complex assembly" RELATED [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0065003 ! protein-containing complex assembly relationship: regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0043269 name: regulation of ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006811 ! ion transport relationship: regulates GO:0006811 ! ion transport [Term] id: GO:0043270 name: positive regulation of ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of ion transport" NARROW [] synonym: "stimulation of ion transport" NARROW [] synonym: "up regulation of ion transport" EXACT [] synonym: "up-regulation of ion transport" EXACT [] synonym: "upregulation of ion transport" EXACT [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006811 ! ion transport relationship: positively_regulates GO:0006811 ! ion transport [Term] id: GO:0043271 name: negative regulation of ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of ion transport" EXACT [] synonym: "down-regulation of ion transport" EXACT [] synonym: "downregulation of ion transport" EXACT [] synonym: "inhibition of ion transport" NARROW [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006811 ! ion transport relationship: negatively_regulates GO:0006811 ! ion transport [Term] id: GO:0043278 name: response to morphine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:ef, GOC:jl] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014072 ! response to isoquinoline alkaloid is_a: GO:0072347 ! response to anesthetic [Term] id: GO:0043279 name: response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl] is_a: GO:0010243 ! response to organonitrogen compound [Term] id: GO:0043388 name: positive regulation of DNA binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] synonym: "activation of DNA binding" NARROW [] synonym: "stimulation of DNA binding" NARROW [] synonym: "up regulation of DNA binding" EXACT [] synonym: "up-regulation of DNA binding" EXACT [] synonym: "upregulation of DNA binding" EXACT [] is_a: GO:0051099 ! positive regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003677 ! DNA binding relationship: positively_regulates GO:0003677 ! DNA binding [Term] id: GO:0043392 name: negative regulation of DNA binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] synonym: "down regulation of DNA binding" EXACT [] synonym: "down-regulation of DNA binding" EXACT [] synonym: "downregulation of DNA binding" EXACT [] synonym: "inhibition of DNA binding" NARROW [] is_a: GO:0051100 ! negative regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003677 ! DNA binding relationship: negatively_regulates GO:0003677 ! DNA binding [Term] id: GO:0043393 name: regulation of protein binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005515 ! protein binding relationship: regulates GO:0005515 ! protein binding [Term] id: GO:0043401 name: steroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724] synonym: "steroid hormone mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: goslim_pir is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0043413 name: macromolecule glycosylation namespace: biological_process def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl] is_a: GO:0043412 ! macromolecule modification is_a: GO:0070085 ! glycosylation [Term] id: GO:0043414 name: macromolecule methylation namespace: biological_process def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators] is_a: GO:0032259 ! methylation is_a: GO:0043412 ! macromolecule modification is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process [Term] id: GO:0043549 name: regulation of kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016301 ! kinase activity relationship: regulates GO:0016301 ! kinase activity [Term] id: GO:0043590 name: bacterial nucleoid namespace: cellular_component def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0043603 name: cellular amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] subset: goslim_pir synonym: "amide metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0043618 name: regulation of transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0043620 ! regulation of DNA-templated transcription in response to stress [Term] id: GO:0043620 name: regulation of DNA-templated transcription in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH] synonym: "regulation of DNA-dependent transcription in response to stress" EXACT [GOC:txnOH] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0043648 name: dicarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "dicarboxylate metabolic process" EXACT [] synonym: "dicarboxylate metabolism" EXACT [] synonym: "dicarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0043655 name: host extracellular space namespace: cellular_component def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc] synonym: "extracellular space of host" EXACT [] synonym: "host extracellular space" EXACT [] is_a: GO:0018995 ! host cellular component [Term] id: GO:0043656 name: host intracellular region namespace: cellular_component def: "That space within the plasma membrane of a host cell." [GOC:cc] synonym: "host intracellular" EXACT [] synonym: "intracellular region of host" EXACT [] is_a: GO:0033643 ! host cell part [Term] id: GO:0043657 name: host cell namespace: cellular_component def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl] is_a: GO:0018995 ! host cellular component [Term] id: GO:0043900 name: regulation of multi-organism process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051704 ! multi-organism process relationship: regulates GO:0051704 ! multi-organism process [Term] id: GO:0043901 name: negative regulation of multi-organism process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051704 ! multi-organism process relationship: negatively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043902 name: positive regulation of multi-organism process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051704 ! multi-organism process relationship: positively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043903 name: regulation of symbiosis, encompassing mutualism through parasitism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044403 ! symbiotic process relationship: regulates GO:0044403 ! symbiotic process [Term] id: GO:0043933 name: protein-containing complex subunit organization namespace: biological_process alt_id: GO:0034600 alt_id: GO:0034621 alt_id: GO:0071822 def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] synonym: "cellular macromolecular complex organization" RELATED [] synonym: "cellular macromolecular complex subunit organisation" RELATED [] synonym: "cellular macromolecular complex subunit organization" RELATED [] synonym: "macromolecular complex organization" RELATED [] synonym: "macromolecular complex subunit organisation" RELATED [] synonym: "macromolecular complex subunit organization" RELATED [] synonym: "protein complex subunit organisation" EXACT [GOC:mah] synonym: "protein complex subunit organization" EXACT [] is_a: GO:0016043 ! cellular component organization created_by: midori creation_date: 2010-09-08T10:01:42Z [Term] id: GO:0043946 name: positive regulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "activation of enzyme activity in other organism" NARROW [] synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation of catalytic activity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0043948 name: induction by symbiont of host catalytic activity namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host enzyme activity" NARROW [] synonym: "activation of host enzyme activity" NARROW [] synonym: "positive regulation by symbiont of host catalytic activity" EXACT [] synonym: "positive regulation by symbiont of host enzyme activity" EXACT [] synonym: "up regulation by symbiont of host enzyme activity" EXACT [] synonym: "up-regulation by symbiont of host enzyme activity" EXACT [] synonym: "upregulation by symbiont of host enzyme activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052148 ! modulation by symbiont of host catalytic activity intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0044003 name: modulation by symbiont of host process namespace: biological_process alt_id: GO:0044004 alt_id: GO:0044055 def: "The process in which a symbiont organism effects a change in the structure or processes of its host organism." [GOC:cc] synonym: "disruption by symbiont of host cell" RELATED [] synonym: "modification by symbiont of host biological process" RELATED [] synonym: "modification by symbiont of host morphology or physiology" RELATED [] synonym: "modulation by symbiont of host system process" NARROW [] synonym: "regulation by symbiont of host system process" NARROW [] is_a: GO:0051701 ! interaction with host is_a: GO:0051817 ! modulation of process of other organism involved in symbiotic interaction property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18719 xsd:anyURI [Term] id: GO:0044010 name: single-species biofilm formation namespace: biological_process alt_id: GO:0052000 def: "A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb] synonym: "auto-aggregation" BROAD [] synonym: "bfp-dependent aggregation" NARROW [] synonym: "bundle-forming fimbriae-dependent aggregation" NARROW [] synonym: "bundle-forming pili-dependent aggregation" NARROW [] synonym: "tfp-dependent aggregation" NARROW [] synonym: "type IV pili-dependent aggregation" NARROW [] is_a: GO:0042710 ! biofilm formation is_a: GO:0051703 ! intraspecies interaction between organisms property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18814 xsd:anyURI [Term] id: GO:0044011 name: single-species biofilm formation on inanimate substrate namespace: biological_process def: "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] is_a: GO:0090609 ! single-species submerged biofilm formation [Term] id: GO:0044030 name: regulation of DNA methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006306 ! DNA methylation relationship: regulates GO:0006306 ! DNA methylation [Term] id: GO:0044046 name: obsolete interaction with host via substance released outside of symbiont namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk] comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. synonym: "interaction with host via substance released outside of symbiont cells" EXACT [] is_obsolete: true [Term] id: GO:0044057 name: regulation of system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003008 ! system process relationship: regulates GO:0003008 ! system process [Term] id: GO:0044062 name: regulation of excretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl] is_a: GO:0044057 ! regulation of system process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007588 ! excretion relationship: regulates GO:0007588 ! excretion [Term] id: GO:0044063 name: modulation by symbiont of host nervous system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk] synonym: "modulation by symbiont of host neurological system process" EXACT [] synonym: "regulation by symbiont of host neurological system process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0044003 ! modulation by symbiont of host process intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0050877 ! nervous system process [Term] id: GO:0044068 name: modulation by symbiont of host cellular process namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism." [MITRE:tk] synonym: "modulation of host cellular process by symbiont" EXACT [] synonym: "regulation by symbiont of host cellular process" EXACT [] synonym: "regulation of host cellular process by symbiont" EXACT [] is_a: GO:0044003 ! modulation by symbiont of host process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0009987 ! cellular process [Term] id: GO:0044069 name: modulation by symbiont of host anion transport namespace: biological_process def: "The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism." [MITRE:tk] synonym: "modification of host anion transport by symbiont" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0006820 ! anion transport [Term] id: GO:0044070 name: regulation of anion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006820 ! anion transport relationship: regulates GO:0006820 ! anion transport [Term] id: GO:0044071 name: modulation by symbiont of host cell cycle namespace: biological_process def: "The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery." [MITRE:tk] synonym: "modification by symbiont of host cell cycle" EXACT [] synonym: "modulation of host cell cycle by symbiont" EXACT [] synonym: "regulation by symbiont of host cell cycle" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0022402 ! cell cycle process [Term] id: GO:0044072 name: negative regulation by symbiont of host cell cycle namespace: biological_process def: "The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery." [MITRE:tk] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0044071 ! modulation by symbiont of host cell cycle intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: negatively_regulates GO:0022402 ! cell cycle process [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044085 ! cellular component biogenesis relationship: regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044088 name: regulation of vacuole organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007033 ! vacuole organization relationship: regulates GO:0007033 ! vacuole organization [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044085 ! cellular component biogenesis relationship: positively_regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044090 name: positive regulation of vacuole organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007033 ! vacuole organization relationship: positively_regulates GO:0007033 ! vacuole organization [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003674 ! molecular_function relationship: negatively_regulates GO:0003674 ! molecular_function created_by: jane creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003674 ! molecular_function relationship: positively_regulates GO:0003674 ! molecular_function created_by: jane creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044110 name: growth involved in symbiotic interaction namespace: biological_process alt_id: GO:0044153 def: "The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'development during symbiotic interaction ; GO:0044111'. synonym: "growth during symbiotic interaction" RELATED [GOC:dph] synonym: "growth on or near surface of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "growth on or near surface of other organism involved in symbiotic interaction" RELATED [] is_a: GO:0040007 ! growth is_a: GO:0044419 ! interspecies interaction between organisms created_by: jane creation_date: 2009-07-30T02:22:33Z [Term] id: GO:0044111 name: development involved in symbiotic interaction namespace: biological_process alt_id: GO:0044152 def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'growth during symbiotic interaction ; GO:0044110'. synonym: "development during symbiotic interaction" RELATED [gOC:dph] synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "development on or near surface of other organism involved in symbiotic interaction" NARROW [] is_a: GO:0032502 ! developmental process is_a: GO:0051704 ! multi-organism process intersection_of: GO:0032502 ! developmental process intersection_of: part_of GO:0044419 ! interspecies interaction between organisms relationship: part_of GO:0044419 ! interspecies interaction between organisms created_by: jane creation_date: 2009-07-30T02:26:46Z [Term] id: GO:0044215 name: obsolete other organism namespace: cellular_component def: "OBSOLETE. A secondary organism with which the first organism is interacting." [GOC:jl] comment: This term was obsoleted because it represents an organism, which is outside the scope of GO. is_obsolete: true created_by: jane creation_date: 2009-11-12T01:04:58Z [Term] id: GO:0044216 name: other organism cell namespace: cellular_component def: "A cell of a secondary organism with which the first organism is interacting." [GOC:jl] is_a: GO:0044217 ! other organism part created_by: jane creation_date: 2009-11-12T01:17:06Z [Term] id: GO:0044217 name: other organism part namespace: cellular_component def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0005575 ! cellular_component created_by: jane creation_date: 2009-11-12T01:18:21Z [Term] id: GO:0044237 name: cellular metabolic process namespace: biological_process def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] subset: goslim_pir synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0044248 name: cellular catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl] synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044249 name: cellular biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] synonym: "cellular anabolism" EXACT [] synonym: "cellular biosynthesis" EXACT [] synonym: "cellular formation" EXACT [] synonym: "cellular synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044255 name: cellular lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] subset: goslim_pir synonym: "cellular lipid metabolism" EXACT [] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044260 name: cellular macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [GOC:mah] synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044267 name: cellular protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] synonym: "cellular protein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] synonym: "nitrogen compound anabolism" BROAD [] synonym: "nitrogen compound biosynthesis" BROAD [] synonym: "nitrogen compound formation" BROAD [] synonym: "nitrogen compound synthesis" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: jane creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process created_by: jane creation_date: 2010-01-26T12:06:49Z [Term] id: GO:0044359 name: modulation of molecular function in other organism namespace: biological_process def: "The process in which an organism effects a change in the function of proteins in a second organism." [GOC:jl] is_a: GO:0035821 ! modulation of process of other organism created_by: janelomax creation_date: 2011-10-27T01:28:16Z [Term] id: GO:0044362 name: negative regulation of molecular function in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0044359 ! modulation of molecular function in other organism created_by: janelomax creation_date: 2011-10-27T02:12:49Z [Term] id: GO:0044364 name: disruption of cells of other organism namespace: biological_process def: "A process in which an organism has a negative effect on the functioning of the second organism's cells." [GOC:jl] is_a: GO:0035821 ! modulation of process of other organism created_by: janelomax creation_date: 2011-10-27T02:27:48Z [Term] id: GO:0044403 name: symbiosis, encompassing mutualism through parasitism name: symbiotic process namespace: biological_process alt_id: GO:0043298 alt_id: GO:0044404 alt_id: GO:0072519 alt_id: GO:0085031 def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, https://study.com/academy/lesson/symbiont-definition-lesson-quiz.html] subset: goslim_chembl subset: goslim_generic synonym: "commensalism" NARROW [] synonym: "host-pathogen interaction" NARROW [] synonym: "parasitism" NARROW [] synonym: "symbiosis" RELATED [] synonym: "symbiosis, encompassing mutualism through parasitism" RELATED [] synonym: "symbiotic interaction" RELATED [] synonym: "symbiotic interaction between host and organism" RELATED [] synonym: "symbiotic interaction between organisms" RELATED [] synonym: "symbiotic interaction between species" RELATED [] is_a: GO:0044419 ! interspecies interaction between organisms property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14807 xsd:anyURI [Term] id: GO:0044419 name: interspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of a different species." [GOC:cc] subset: goslim_candida subset: goslim_pir synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] is_a: GO:0051704 ! multi-organism process property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0044420 name: obsolete extracellular matrix component namespace: cellular_component def: "OBSOLETE. Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "extracellular matrix part" EXACT [] is_obsolete: true consider: GO:0031012 [Term] id: GO:0044421 name: obsolete extracellular region part namespace: cellular_component def: "OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "extracellular structure" RELATED [NIF_Subcellular:sao9117790637] xref: NIF_Subcellular:sao9117790637 is_obsolete: true consider: GO:0005576 [Term] id: GO:0044422 name: obsolete organelle part namespace: cellular_component def: "OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0043226 [Term] id: GO:0044424 name: obsolete intracellular part namespace: cellular_component def: "OBSOLETE. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005622 [Term] id: GO:0044425 name: obsolete membrane part namespace: cellular_component def: "OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0016020 [Term] id: GO:0044426 name: obsolete cell wall part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005618 [Term] id: GO:0044428 name: obsolete nuclear part namespace: cellular_component def: "OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "nuclear subcomponent" EXACT [NIF_Subcellular:sao1499850686] synonym: "nucleus component" EXACT [] xref: NIF_Subcellular:sao1499850686 is_obsolete: true consider: GO:0005634 [Term] id: GO:0044429 name: obsolete mitochondrial part namespace: cellular_component def: "OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "mitochondrial subcomponent" EXACT [NIF_Subcellular:sao666410040] synonym: "mitochondrion component" EXACT [] xref: NIF_Subcellular:sao666410040 is_obsolete: true consider: GO:0005739 [Term] id: GO:0044430 name: obsolete cytoskeletal part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cytoskeletal element" EXACT [NIF_Subcellular:sao1635329413] synonym: "cytoskeleton component" EXACT [] xref: NIF_Subcellular:sao1635329413 is_obsolete: true consider: GO:0005856 [Term] id: GO:0044431 name: obsolete Golgi apparatus part namespace: cellular_component def: "OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "Golgi component" EXACT [] synonym: "Golgi subcomponent" EXACT [NIF_Subcellular:sao624292949] xref: NIF_Subcellular:sao624292949 is_obsolete: true consider: GO:0005794 [Term] id: GO:0044432 name: obsolete endoplasmic reticulum part namespace: cellular_component def: "OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "ER component" EXACT [] is_obsolete: true consider: GO:0005783 [Term] id: GO:0044433 name: obsolete cytoplasmic vesicle part namespace: cellular_component def: "OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0031410 [Term] id: GO:0044434 name: obsolete chloroplast part namespace: cellular_component def: "OBSOLETE. Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0009507 [Term] id: GO:0044435 name: obsolete plastid part namespace: cellular_component def: "OBSOLETE. Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0009536 [Term] id: GO:0044436 name: obsolete thylakoid part namespace: cellular_component def: "OBSOLETE. Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0009579 [Term] id: GO:0044437 name: obsolete vacuolar part namespace: cellular_component def: "OBSOLETE. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "vacuole component" EXACT [] is_obsolete: true consider: GO:0005773 [Term] id: GO:0044441 name: obsolete ciliary part namespace: cellular_component alt_id: GO:0044442 def: "OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent. subset: gocheck_do_not_annotate synonym: "cilial part" EXACT [] synonym: "cilium part" EXACT [] synonym: "flagellar part" NARROW [] synonym: "flagellum component" NARROW [] synonym: "flagellum part" NARROW [] synonym: "microtubule-based flagellum part" EXACT [] is_obsolete: true consider: GO:0005929 [Term] id: GO:0044444 name: obsolete cytoplasmic part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cytoplasm component" EXACT [] is_obsolete: true consider: GO:0005737 [Term] id: GO:0044445 name: obsolete cytosolic part namespace: cellular_component def: "OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cytosol component" EXACT [] is_obsolete: true consider: GO:0005829 [Term] id: GO:0044446 name: obsolete intracellular organelle part namespace: cellular_component def: "OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0043229 [Term] id: GO:0044452 name: obsolete nucleolar part namespace: cellular_component def: "OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "nucleolus component" EXACT [] is_obsolete: true consider: GO:0005730 [Term] id: GO:0044456 name: obsolete synapse part name: synapse part namespace: cellular_component def: "OBSOLETE. Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "synaptic component" RELATED [NIF_Subcellular:sao1784069613] xref: NIF_Subcellular:sao1784069613 is_a: GO:0044464 ! obsolete cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl is_obsolete: true consider: GO:0045202 [Term] id: GO:0044459 name: obsolete plasma membrane part namespace: cellular_component def: "OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005886 [Term] id: GO:0044462 name: obsolete external encapsulating structure part namespace: cellular_component def: "OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria)." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0030312 [Term] id: GO:0044463 name: obsolete cell projection part namespace: cellular_component def: "OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0042995 [Term] id: GO:0044464 name: cell part name: obsolete cell part namespace: cellular_component def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602] synonym: "protoplast" RELATED [GOC:mah] xref: NIF_Subcellular:sao628508602 is_a: CARO:0000014 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl is_obsolete: true consider: CL:0000000 [Term] id: GO:0044531 name: modulation of programmed cell death in other organism namespace: biological_process def: "A process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism." [GOC:jl] is_a: GO:0035821 ! modulation of process of other organism is_a: GO:0043067 ! regulation of programmed cell death created_by: janelomax creation_date: 2012-03-20T04:48:41Z [Term] id: GO:0044532 name: modulation of apoptotic process in other organism namespace: biological_process def: "A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism." [GOC:jl] synonym: "regulation of apoptotic process in other organism" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0044531 ! modulation of programmed cell death in other organism created_by: janelomax creation_date: 2012-03-21T11:17:18Z [Term] id: GO:0044691 name: tooth eruption namespace: biological_process def: "The tooth development process in which the teeth enter the mouth and become visible." [Wikipedia:Tooth_eruption] xref: Wikipedia:Tooth_eruption is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0042476 ! odontogenesis created_by: janelomax creation_date: 2012-08-15T14:58:17Z [Term] id: GO:0044703 name: multi-organism reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process created_by: janelomax creation_date: 2012-09-19T15:56:30Z [Term] id: GO:0044705 name: multi-organism reproductive behavior namespace: biological_process def: "The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species." [GOC:jl, GOC:pr] is_a: GO:0019098 ! reproductive behavior created_by: janelomax creation_date: 2012-09-19T16:02:12Z [Term] id: GO:0044706 name: multi-multicellular organism process namespace: biological_process def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0051704 ! multi-organism process created_by: janelomax creation_date: 2012-09-19T16:06:16Z [Term] id: GO:0044728 name: DNA methylation or demethylation namespace: biological_process def: "The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule." [GOC:jl] synonym: "changes in DNA methylation" RELATED [] is_a: GO:0006304 ! DNA modification created_by: janelomax creation_date: 2012-10-24T14:49:41Z [Term] id: GO:0044764 name: multi-organism cellular process namespace: biological_process def: "Any process that is carried out at the cellular level which involves another organism of the same or different species." [GOC:jl] is_a: GO:0009987 ! cellular process is_a: GO:0051704 ! multi-organism process created_by: janelomax creation_date: 2012-12-11T17:00:50Z [Term] id: GO:0044766 name: multi-organism transport namespace: biological_process def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism." [GOC:jl] is_a: GO:0006810 ! transport is_a: GO:1902579 ! multi-organism localization created_by: janelomax creation_date: 2012-12-13T16:25:50Z [Term] id: GO:0044782 name: cilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. subset: goslim_drosophila synonym: "microtubule-based flagellum organization" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: janelomax creation_date: 2013-03-27T15:09:58Z [Term] id: GO:0044848 name: biological phase namespace: biological_process def: "A distinct period or stage in a biological process or cycle." [GOC:jl] comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. subset: gocheck_do_not_manually_annotate is_a: GO:0008150 ! biological_process disjoint_from: GO:0048511 ! rhythmic process disjoint_from: GO:0050896 ! response to stimulus disjoint_from: GO:0051179 ! localization disjoint_from: GO:0051704 ! multi-organism process disjoint_from: GO:0071840 ! cellular component organization or biogenesis disjoint_from: GO:0098743 ! cell aggregation created_by: janelomax creation_date: 2014-07-16T13:12:40Z [Term] id: GO:0044853 name: plasma membrane raft namespace: cellular_component def: "A membrane raft that is part of the plasma membrane." [GOC:jl] is_a: GO:0045121 ! membrane raft is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0045121 ! membrane raft intersection_of: part_of GO:0005886 ! plasma membrane created_by: janelomax creation_date: 2014-07-23T15:55:23Z [Term] id: GO:0045121 name: membrane raft namespace: cellular_component def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567] synonym: "GEM domain" RELATED [] synonym: "glycolipid-enriched membrane domain" RELATED [] synonym: "lipid raft" EXACT [] xref: Wikipedia:Lipid_raft is_a: GO:0098857 ! membrane microdomain [Term] id: GO:0045132 name: meiotic chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] is_a: GO:0098813 ! nuclear chromosome segregation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0140013 ! meiotic nuclear division relationship: part_of GO:0140013 ! meiotic nuclear division [Term] id: GO:0045144 name: meiotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] synonym: "meiosis II, chromosome segregation" EXACT [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0045132 ! meiotic chromosome segregation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0000819 ! sister chromatid segregation intersection_of: part_of GO:0007135 ! meiosis II relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0045161 name: neuronal ion channel clustering namespace: biological_process def: "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0042551 ! neuron maturation [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051234 ! establishment of localization [Term] id: GO:0045187 name: regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] synonym: "regulation of sleep" EXACT [] is_a: GO:0042749 ! regulation of circadian sleep/wake cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050802 ! circadian sleep/wake cycle, sleep relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0045188 name: regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators] synonym: "regulation of non-REM sleep" EXACT [] is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0045202 name: synapse namespace: cellular_component def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_synapse synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497] synonym: "synaptic junction" EXACT [] xref: NIF_Subcellular:sao914572699 xref: Wikipedia:Chemical_synapse is_a: CARO:0000003 ! anatomical structure is_a: GO:0030054 ! cell junction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045321 name: leukocyte activation namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] synonym: "immune cell activation" EXACT [] synonym: "leucocyte activation" EXACT [] xref: Wikipedia:Immunologic_activation is_a: GO:0001775 ! cell activation is_a: GO:0002376 ! immune system process [Term] id: GO:0045472 name: response to ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0045475 name: locomotor rhythm namespace: biological_process def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] synonym: "circadian locomotor activity rhythm" NARROW [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0048512 ! circadian behavior [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030154 ! cell differentiation relationship: regulates GO:0030154 ! cell differentiation [Term] id: GO:0045596 name: negative regulation of cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "down regulation of cell differentiation" EXACT [] synonym: "down-regulation of cell differentiation" EXACT [] synonym: "downregulation of cell differentiation" EXACT [] synonym: "inhibition of cell differentiation" NARROW [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030154 ! cell differentiation relationship: negatively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045597 name: positive regulation of cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "activation of cell differentiation" NARROW [] synonym: "stimulation of cell differentiation" NARROW [] synonym: "up regulation of cell differentiation" EXACT [] synonym: "up-regulation of cell differentiation" EXACT [] synonym: "upregulation of cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030154 ! cell differentiation relationship: positively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045637 name: regulation of myeloid cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030099 ! myeloid cell differentiation relationship: regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045638 name: negative regulation of myeloid cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "down regulation of myeloid cell differentiation" EXACT [] synonym: "down-regulation of myeloid cell differentiation" EXACT [] synonym: "downregulation of myeloid cell differentiation" EXACT [] synonym: "inhibition of myeloid cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030099 ! myeloid cell differentiation relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045639 name: positive regulation of myeloid cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "activation of myeloid cell differentiation" NARROW [] synonym: "stimulation of myeloid cell differentiation" NARROW [] synonym: "up regulation of myeloid cell differentiation" EXACT [] synonym: "up-regulation of myeloid cell differentiation" EXACT [] synonym: "upregulation of myeloid cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030099 ! myeloid cell differentiation relationship: positively_regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045646 name: regulation of erythrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "regulation of RBC differentiation" EXACT [CL:0000232] synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030218 ! erythrocyte differentiation relationship: regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045647 name: negative regulation of erythrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "down regulation of erythrocyte differentiation" EXACT [] synonym: "down-regulation of erythrocyte differentiation" EXACT [] synonym: "downregulation of erythrocyte differentiation" EXACT [] synonym: "inhibition of erythrocyte differentiation" NARROW [] synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030218 ! erythrocyte differentiation relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045648 name: positive regulation of erythrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "activation of erythrocyte differentiation" NARROW [] synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232] synonym: "stimulation of erythrocyte differentiation" NARROW [] synonym: "up regulation of erythrocyte differentiation" EXACT [] synonym: "up-regulation of erythrocyte differentiation" EXACT [] synonym: "upregulation of erythrocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030218 ! erythrocyte differentiation relationship: positively_regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045664 name: regulation of neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] is_a: GO:0050767 ! regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030182 ! neuron differentiation relationship: regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045665 name: negative regulation of neuron differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "down regulation of neuron differentiation" EXACT [] synonym: "down-regulation of neuron differentiation" EXACT [] synonym: "downregulation of neuron differentiation" EXACT [] synonym: "inhibition of neuron differentiation" NARROW [] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030182 ! neuron differentiation relationship: negatively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045666 name: positive regulation of neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "activation of neuron differentiation" NARROW [] synonym: "stimulation of neuron differentiation" NARROW [] synonym: "up regulation of neuron differentiation" EXACT [] synonym: "up-regulation of neuron differentiation" EXACT [] synonym: "upregulation of neuron differentiation" EXACT [] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030182 ! neuron differentiation relationship: positively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045700 name: regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:1903353 ! regulation of nucleus organization is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007289 ! spermatid nucleus differentiation relationship: regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045701 name: negative regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "down regulation of spermatid nuclear differentiation" EXACT [] synonym: "down-regulation of spermatid nuclear differentiation" EXACT [] synonym: "downregulation of spermatid nuclear differentiation" EXACT [] synonym: "inhibition of spermatid nuclear differentiation" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007289 ! spermatid nucleus differentiation relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045702 name: positive regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "activation of spermatid nuclear differentiation" NARROW [] synonym: "stimulation of spermatid nuclear differentiation" NARROW [] synonym: "up regulation of spermatid nuclear differentiation" EXACT [] synonym: "up-regulation of spermatid nuclear differentiation" EXACT [] synonym: "upregulation of spermatid nuclear differentiation" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007289 ! spermatid nucleus differentiation relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045724 name: positive regulation of cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators] synonym: "activation of cilium assembly" NARROW [] synonym: "positive regulation of flagellum assembly" BROAD [] synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] synonym: "stimulation of cilium assembly" NARROW [] synonym: "up regulation of cilium assembly" EXACT [] synonym: "up-regulation of cilium assembly" EXACT [] synonym: "upregulation of cilium assembly" EXACT [] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060271 ! cilium assembly relationship: positively_regulates GO:0060271 ! cilium assembly [Term] id: GO:0045744 name: negative regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of GPCR protein signaling pathway" EXACT [] synonym: "negative regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway relationship: negatively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0045745 name: positive regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of GPCR protein signaling pathway" EXACT [] synonym: "positive regulation of GPCR protein signalling pathway" EXACT [] synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway relationship: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0045765 name: regulation of angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001525 ! angiogenesis relationship: regulates GO:0001525 ! angiogenesis [Term] id: GO:0045766 name: positive regulation of angiogenesis namespace: biological_process def: "Any process that activates or increases angiogenesis." [GOC:go_curators] synonym: "activation of angiogenesis" NARROW [] synonym: "stimulation of angiogenesis" NARROW [] synonym: "up regulation of angiogenesis" EXACT [] synonym: "up-regulation of angiogenesis" EXACT [] synonym: "upregulation of angiogenesis" EXACT [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001525 ! angiogenesis relationship: positively_regulates GO:0001525 ! angiogenesis [Term] id: GO:0045769 name: negative regulation of asymmetric cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "down regulation of asymmetric cell division" EXACT [] synonym: "down-regulation of asymmetric cell division" EXACT [] synonym: "downregulation of asymmetric cell division" EXACT [] synonym: "inhibition of asymmetric cell division" NARROW [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008356 ! asymmetric cell division relationship: negatively_regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0045770 name: positive regulation of asymmetric cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "activation of asymmetric cell division" NARROW [] synonym: "stimulation of asymmetric cell division" NARROW [] synonym: "up regulation of asymmetric cell division" EXACT [] synonym: "up-regulation of asymmetric cell division" EXACT [] synonym: "upregulation of asymmetric cell division" EXACT [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051781 ! positive regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008356 ! asymmetric cell division relationship: positively_regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0045785 name: positive regulation of cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "activation of cell adhesion" NARROW [] synonym: "stimulation of cell adhesion" NARROW [] synonym: "up regulation of cell adhesion" EXACT [] synonym: "up-regulation of cell adhesion" EXACT [] synonym: "upregulation of cell adhesion" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007155 ! cell adhesion relationship: positively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007049 ! cell cycle relationship: negatively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007049 ! cell cycle relationship: positively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045827 name: negative regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] synonym: "down regulation of isoprenoid metabolic process" EXACT [] synonym: "down-regulation of isoprenoid metabolic process" EXACT [] synonym: "downregulation of isoprenoid metabolic process" EXACT [] synonym: "inhibition of isoprenoid metabolic process" NARROW [] synonym: "negative regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006720 ! isoprenoid metabolic process relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0045828 name: positive regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] synonym: "activation of isoprenoid metabolic process" NARROW [] synonym: "positive regulation of isoprenoid metabolism" EXACT [] synonym: "stimulation of isoprenoid metabolic process" NARROW [] synonym: "up regulation of isoprenoid metabolic process" EXACT [] synonym: "up-regulation of isoprenoid metabolic process" EXACT [] synonym: "upregulation of isoprenoid metabolic process" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006720 ! isoprenoid metabolic process relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0045833 name: negative regulation of lipid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "down regulation of lipid metabolic process" EXACT [] synonym: "down-regulation of lipid metabolic process" EXACT [] synonym: "downregulation of lipid metabolic process" EXACT [] synonym: "inhibition of lipid metabolic process" NARROW [] synonym: "negative regulation of lipid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006629 ! lipid metabolic process relationship: negatively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045834 name: positive regulation of lipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "activation of lipid metabolic process" NARROW [] synonym: "positive regulation of lipid metabolism" EXACT [] synonym: "stimulation of lipid metabolic process" NARROW [] synonym: "up regulation of lipid metabolic process" EXACT [] synonym: "up-regulation of lipid metabolic process" EXACT [] synonym: "upregulation of lipid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006629 ! lipid metabolic process relationship: positively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045835 name: negative regulation of meiotic nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] synonym: "negative regulation of meiosis" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0140013 ! meiotic nuclear division relationship: negatively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045836 name: positive regulation of meiotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "positive regulation of meiosis" EXACT [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0140013 ! meiotic nuclear division relationship: positively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045839 name: negative regulation of mitotic nuclear division namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] synonym: "negative regulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0140014 ! mitotic nuclear division relationship: negatively_regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0045840 name: positive regulation of mitotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "positive regulation of mitosis" EXACT [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0140014 ! mitotic nuclear division relationship: positively_regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0045861 name: negative regulation of proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "down regulation of proteolysis" EXACT [] synonym: "down-regulation of proteolysis" EXACT [] synonym: "downregulation of proteolysis" EXACT [] synonym: "inhibition of proteolysis" NARROW [] synonym: "negative regulation of peptidolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006508 ! proteolysis relationship: negatively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045862 name: positive regulation of proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "activation of proteolysis" NARROW [] synonym: "positive regulation of peptidolysis" EXACT [] synonym: "stimulation of proteolysis" NARROW [] synonym: "up regulation of proteolysis" EXACT [] synonym: "up-regulation of proteolysis" EXACT [] synonym: "upregulation of proteolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006508 ! proteolysis relationship: positively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045892 name: negative regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0016481 alt_id: GO:0032582 alt_id: GO:0061021 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of gene-specific transcription" RELATED [] synonym: "down regulation of transcription, DNA-dependent" EXACT [] synonym: "down-regulation of gene-specific transcription" RELATED [] synonym: "down-regulation of transcription, DNA-dependent" EXACT [] synonym: "downregulation of gene-specific transcription" RELATED [] synonym: "downregulation of transcription, DNA-dependent" EXACT [] synonym: "inhibition of gene-specific transcription" RELATED [] synonym: "inhibition of transcription, DNA-dependent" NARROW [] synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "negative regulation of gene-specific transcription" RELATED [] synonym: "negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcription repressor activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006351 ! transcription, DNA-templated relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0045893 name: positive regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0043193 alt_id: GO:0045941 alt_id: GO:0061020 def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "activation of gene-specific transcription" RELATED [] synonym: "activation of transcription, DNA-dependent" NARROW [] synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "positive regulation of gene-specific transcription" RELATED [] synonym: "positive regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "stimulation of gene-specific transcription" NARROW [] synonym: "stimulation of transcription, DNA-dependent" NARROW [] synonym: "transcription activator activity" RELATED [] synonym: "up regulation of gene-specific transcription" RELATED [] synonym: "up regulation of transcription, DNA-dependent" EXACT [] synonym: "up-regulation of gene-specific transcription" RELATED [] synonym: "up-regulation of transcription, DNA-dependent" EXACT [] synonym: "upregulation of gene-specific transcription" RELATED [] synonym: "upregulation of transcription, DNA-dependent" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006351 ! transcription, DNA-templated relationship: positively_regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0045912 name: negative regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "down regulation of carbohydrate metabolic process" EXACT [] synonym: "down-regulation of carbohydrate metabolic process" EXACT [] synonym: "downregulation of carbohydrate metabolic process" EXACT [] synonym: "inhibition of carbohydrate metabolic process" NARROW [] synonym: "negative regulation of carbohydrate metabolism" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005975 ! carbohydrate metabolic process relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0045913 name: positive regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "activation of carbohydrate metabolic process" NARROW [] synonym: "positive regulation of carbohydrate metabolism" EXACT [] synonym: "stimulation of carbohydrate metabolic process" NARROW [] synonym: "up regulation of carbohydrate metabolic process" EXACT [] synonym: "up-regulation of carbohydrate metabolic process" EXACT [] synonym: "upregulation of carbohydrate metabolic process" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005975 ! carbohydrate metabolic process relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0045926 name: negative regulation of growth namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "down regulation of growth" EXACT [] synonym: "down-regulation of growth" EXACT [] synonym: "downregulation of growth" EXACT [] synonym: "inhibition of growth" NARROW [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0040007 ! growth relationship: negatively_regulates GO:0040007 ! growth [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0040007 ! growth relationship: positively_regulates GO:0040007 ! growth [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000278 ! mitotic cell cycle relationship: negatively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000278 ! mitotic cell cycle relationship: positively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045936 name: negative regulation of phosphate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "down regulation of phosphate metabolic process" EXACT [] synonym: "down-regulation of phosphate metabolic process" EXACT [] synonym: "downregulation of phosphate metabolic process" EXACT [] synonym: "inhibition of phosphate metabolic process" NARROW [] synonym: "negative regulation of phosphate metabolism" EXACT [] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045937 name: positive regulation of phosphate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "activation of phosphate metabolic process" NARROW [] synonym: "positive regulation of phosphate metabolism" EXACT [] synonym: "stimulation of phosphate metabolic process" NARROW [] synonym: "up regulation of phosphate metabolic process" EXACT [] synonym: "up-regulation of phosphate metabolic process" EXACT [] synonym: "upregulation of phosphate metabolic process" EXACT [] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045938 name: positive regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, sleep" NARROW [] synonym: "positive regulation of sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT [] is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0045944 name: positive regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0010552 alt_id: GO:0045817 def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "activation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "activation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of global transcription from Pol II promoter" RELATED [] synonym: "positive regulation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED [] synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II relationship: positively_regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0045978 name: negative regulation of nucleoside metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] synonym: "down regulation of nucleoside metabolic process" EXACT [] synonym: "down-regulation of nucleoside metabolic process" EXACT [] synonym: "downregulation of nucleoside metabolic process" EXACT [] synonym: "inhibition of nucleoside metabolic process" NARROW [] synonym: "negative regulation of nucleoside metabolism" EXACT [] is_a: GO:0009118 ! regulation of nucleoside metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009116 ! nucleoside metabolic process relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0045979 name: positive regulation of nucleoside metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] synonym: "activation of nucleoside metabolic process" NARROW [] synonym: "positive regulation of nucleoside metabolism" EXACT [] synonym: "stimulation of nucleoside metabolic process" NARROW [] synonym: "up regulation of nucleoside metabolic process" EXACT [] synonym: "up-regulation of nucleoside metabolic process" EXACT [] synonym: "upregulation of nucleoside metabolic process" EXACT [] is_a: GO:0009118 ! regulation of nucleoside metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009116 ! nucleoside metabolic process relationship: positively_regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0045980 name: negative regulation of nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "down regulation of nucleotide metabolic process" EXACT [] synonym: "down-regulation of nucleotide metabolic process" EXACT [] synonym: "downregulation of nucleotide metabolic process" EXACT [] synonym: "inhibition of nucleotide metabolic process" NARROW [] synonym: "negative regulation of nucleotide metabolism" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009117 ! nucleotide metabolic process relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0045981 name: positive regulation of nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "activation of nucleotide metabolic process" NARROW [] synonym: "positive regulation of nucleotide metabolism" EXACT [] synonym: "stimulation of nucleotide metabolic process" NARROW [] synonym: "up regulation of nucleotide metabolic process" EXACT [] synonym: "up-regulation of nucleotide metabolic process" EXACT [] synonym: "upregulation of nucleotide metabolic process" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0045937 ! positive regulation of phosphate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009117 ! nucleotide metabolic process relationship: positively_regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0045992 name: negative regulation of embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "down regulation of embryonic development" EXACT [] synonym: "down-regulation of embryonic development" EXACT [] synonym: "downregulation of embryonic development" EXACT [] synonym: "inhibition of embryonic development" NARROW [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009790 ! embryo development relationship: negatively_regulates GO:0009790 ! embryo development [Term] id: GO:0045995 name: regulation of embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009790 ! embryo development relationship: regulates GO:0009790 ! embryo development [Term] id: GO:0046005 name: positive regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "positive regulation of REM sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT [] is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0046010 name: positive regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "positive regulation of non-REM sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0046034 name: ATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] synonym: "ATP metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0046128 name: purine ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "purine ribonucleoside metabolism" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0046129 name: purine ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "purine ribonucleoside anabolism" EXACT [] synonym: "purine ribonucleoside biosynthesis" EXACT [] synonym: "purine ribonucleoside formation" EXACT [] synonym: "purine ribonucleoside synthesis" EXACT [] is_a: GO:0042451 ! purine nucleoside biosynthetic process is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046136 name: positive regulation of vitamin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] synonym: "activation of vitamin metabolic process" NARROW [] synonym: "positive regulation of vitamin metabolism" EXACT [] synonym: "stimulation of vitamin metabolic process" NARROW [] synonym: "up regulation of vitamin metabolic process" EXACT [] synonym: "up-regulation of vitamin metabolic process" EXACT [] synonym: "upregulation of vitamin metabolic process" EXACT [] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006766 ! vitamin metabolic process relationship: positively_regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0046137 name: negative regulation of vitamin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] synonym: "down regulation of vitamin metabolic process" EXACT [] synonym: "down-regulation of vitamin metabolic process" EXACT [] synonym: "downregulation of vitamin metabolic process" EXACT [] synonym: "inhibition of vitamin metabolic process" NARROW [] synonym: "negative regulation of vitamin metabolism" EXACT [] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006766 ! vitamin metabolic process relationship: negatively_regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0046390 name: ribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] synonym: "ribose phosphate anabolism" EXACT [] synonym: "ribose phosphate biosynthesis" EXACT [] synonym: "ribose phosphate formation" EXACT [] synonym: "ribose phosphate synthesis" EXACT [] is_a: GO:0019693 ! ribose phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0046483 name: heterocycle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732] subset: goslim_pir synonym: "heterocycle metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0046649 name: lymphocyte activation namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0046655 name: folic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732] synonym: "folate metabolic process" EXACT [] synonym: "folate metabolism" EXACT [] synonym: "folic acid metabolism" EXACT [] synonym: "vitamin B9 metabolic process" EXACT [] synonym: "vitamin B9 metabolism" EXACT [] synonym: "vitamin M metabolic process" EXACT [] synonym: "vitamin M metabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046677 name: response to antibiotic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] subset: goslim_chembl synonym: "antibiotic susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0046858 name: chlorosome namespace: cellular_component def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732, PMID:14729689, PMID:15298919] xref: Wikipedia:Chlorosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0046907 name: intracellular transport namespace: biological_process alt_id: GO:1902582 def: "The directed movement of substances within a cell." [GOC:ai] synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intracellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0051641 ! cellular localization is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular created_by: jl creation_date: 2013-12-18T14:04:50Z [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport [Term] id: GO:0046943 name: carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane" is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0046956 name: positive phototaxis namespace: biological_process alt_id: GO:0046954 def: "The directed movement of a cell or organism towards a source of light." [GOC:ai] synonym: "positive phototactic behavior" EXACT [] synonym: "positive phototactic behaviour" EXACT [] synonym: "positive taxis in response to light" EXACT [] is_a: GO:0042331 ! phototaxis is_a: GO:0052128 ! positive energy taxis [Term] id: GO:0046957 name: negative phototaxis namespace: biological_process alt_id: GO:0046955 def: "The directed movement of a cell or organism away from a source of light." [GOC:ai] synonym: "negative phototactic behavior" EXACT [] synonym: "negative phototactic behaviour" EXACT [] synonym: "negative taxis in response to light" EXACT [] is_a: GO:0042331 ! phototaxis is_a: GO:0052129 ! negative energy taxis [Term] id: GO:0046958 name: nonassociative learning namespace: biological_process def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089] synonym: "unconditional response" EXACT [] is_a: GO:0007612 ! learning [Term] id: GO:0046959 name: habituation namespace: biological_process def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] xref: Wikipedia:Habituation is_a: GO:0046958 ! nonassociative learning [Term] id: GO:0046960 name: sensitization namespace: biological_process def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089] xref: Wikipedia:Sensitization is_a: GO:0046958 ! nonassociative learning [Term] id: GO:0047484 name: regulation of response to osmotic stress namespace: biological_process def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006970 ! response to osmotic stress relationship: regulates GO:0006970 ! response to osmotic stress [Term] id: GO:0048018 name: receptor ligand activity namespace: molecular_function alt_id: GO:0071884 def: "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt] comment: Definition discussed in https://github.com/geneontology/go-ontology/issues/14220 subset: goslim_chembl subset: goslim_drosophila synonym: "receptor agonist activity" BROAD [GOC:molecular_function_refactoring] synonym: "signaling molecule" EXACT [] synonym: "signaling receptor ligand activity" EXACT [] synonym: "vitamin D receptor activator activity" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0030546 ! signaling receptor activator activity relationship: part_of GO:0007165 ! signal transduction property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14220 xsd:anyURI created_by: midori creation_date: 2010-09-13T04:51:59Z [Term] id: GO:0048046 name: apoplast namespace: cellular_component def: "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jid] xref: Wikipedia:Apoplast is_a: GO:0005576 ! extracellular region [Term] id: GO:0048102 name: autophagic cell death namespace: biological_process def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517] comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not. synonym: "autophagic death" BROAD [] synonym: "autosis" RELATED [PMID:25236395] synonym: "programmed cell death by autophagy" BROAD [GOC:pr] synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm] synonym: "type II programmed cell death" RELATED [GOC:sl] is_a: GO:0012501 ! programmed cell death intersection_of: GO:0012501 ! programmed cell death intersection_of: has_part GO:0016236 ! macroautophagy relationship: has_part GO:0016236 ! macroautophagy [Term] id: GO:0048103 name: somatic stem cell division namespace: biological_process def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] synonym: "somatic stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division [Term] id: GO:0048144 name: fibroblast proliferation namespace: biological_process def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0048145 name: regulation of fibroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048144 ! fibroblast proliferation relationship: regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048146 name: positive regulation of fibroblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "activation of fibroblast proliferation" NARROW [] synonym: "stimulation of fibroblast proliferation" NARROW [] synonym: "up regulation of fibroblast proliferation" EXACT [] synonym: "up-regulation of fibroblast proliferation" EXACT [] synonym: "upregulation of fibroblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048144 ! fibroblast proliferation relationship: positively_regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048147 name: negative regulation of fibroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "down regulation of fibroblast proliferation" EXACT [] synonym: "down-regulation of fibroblast proliferation" EXACT [] synonym: "downregulation of fibroblast proliferation" EXACT [] synonym: "inhibition of fibroblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048144 ! fibroblast proliferation relationship: negatively_regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048193 name: Golgi vesicle transport namespace: biological_process def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] subset: goslim_yeast synonym: "Golgi-derived vesicle transport" RELATED [] is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0048199 name: vesicle targeting, to, from or within Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle targeting" NARROW [] synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048209 name: regulation of vesicle targeting, to, from or within Golgi namespace: biological_process def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "regulation of Golgi vesicle targeting" EXACT [] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi [Term] id: GO:0048232 name: male gamete generation namespace: biological_process def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid] is_a: GO:0007276 ! gamete generation [Term] id: GO:0048237 name: rough endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jid] synonym: "RER lumen" EXACT [] synonym: "rough ER lumen" EXACT [] xref: NIF_Subcellular:sao1819509473 is_a: GO:0005788 ! endoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005791 ! rough endoplasmic reticulum relationship: part_of GO:0005791 ! rough endoplasmic reticulum [Term] id: GO:0048238 name: smooth endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jid] synonym: "SER lumen" EXACT [] synonym: "smooth ER lumen" EXACT [] xref: NIF_Subcellular:sao927884761 is_a: GO:0005788 ! endoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005790 ! smooth endoplasmic reticulum relationship: part_of GO:0005790 ! smooth endoplasmic reticulum [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] subset: goslim_candida synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0048469 name: cell maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators] subset: goslim_pir synonym: "functional differentiation" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048468 ! cell development [Term] id: GO:0048477 name: oogenesis namespace: biological_process alt_id: GO:0009993 alt_id: GO:0048157 def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] synonym: "ovum development" EXACT systematic_synonym [] xref: Wikipedia:Oogenesis is_a: GO:0007281 ! germ cell development is_a: GO:0007292 ! female gamete generation [Term] id: GO:0048511 name: rhythmic process namespace: biological_process def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] subset: goslim_pir synonym: "rhythm" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0048512 name: circadian behavior namespace: biological_process def: "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] synonym: "circadian rhythm behavior" EXACT [] is_a: GO:0007622 ! rhythmic behavior is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0048513 name: animal organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048731 ! system development [Term] id: GO:0048514 name: blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0048515 name: spermatid differentiation namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] synonym: "spermatid cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process alt_id: GO:0043119 def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008150 ! biological_process relationship: positively_regulates GO:0008150 ! biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process alt_id: GO:0043118 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008150 ! biological_process relationship: negatively_regulates GO:0008150 ! biological_process [Term] id: GO:0048520 name: positive regulation of behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "activation of behavior" NARROW [] synonym: "stimulation of behavior" NARROW [] synonym: "up regulation of behavior" EXACT [] synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007610 ! behavior relationship: positively_regulates GO:0007610 ! behavior [Term] id: GO:0048521 name: negative regulation of behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "down regulation of behavior" EXACT [] synonym: "down-regulation of behavior" EXACT [] synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007610 ! behavior relationship: negatively_regulates GO:0007610 ! behavior [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process alt_id: GO:0051242 def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009987 ! cellular process relationship: positively_regulates GO:0009987 ! cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process alt_id: GO:0051243 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009987 ! cellular process relationship: negatively_regulates GO:0009987 ! cellular process [Term] id: GO:0048534 name: hematopoietic or lymphoid organ development namespace: biological_process def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149] synonym: "haematopoietic or lymphoid organ development" EXACT [] synonym: "haemopoietic or lymphoid organ development" EXACT [] synonym: "hemopoietic or lymphoid organ development" EXACT [] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0048545 name: response to steroid hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] synonym: "response to steroid hormone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050896 ! response to stimulus relationship: regulates GO:0050896 ! response to stimulus [Term] id: GO:0048584 name: positive regulation of response to stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to stimulus" NARROW [] synonym: "stimulation of response to stimulus" NARROW [] synonym: "up regulation of response to stimulus" EXACT [] synonym: "up-regulation of response to stimulus" EXACT [] synonym: "upregulation of response to stimulus" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050896 ! response to stimulus relationship: positively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to stimulus" EXACT [] synonym: "down-regulation of response to stimulus" EXACT [] synonym: "downregulation of response to stimulus" EXACT [] synonym: "inhibition of response to stimulus" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050896 ! response to stimulus relationship: negatively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0032502 ! developmental process is_a: GO:0040007 ! growth [Term] id: GO:0048599 name: oocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] is_a: GO:0007281 ! germ cell development relationship: part_of GO:0009994 ! oocyte differentiation [Term] id: GO:0048609 name: multicellular organismal reproductive process namespace: biological_process def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] synonym: "organismal reproductive process" BROAD [] synonym: "reproductive process in a multicellular organism" EXACT [] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048589 ! developmental growth relationship: regulates GO:0048589 ! developmental growth [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048589 ! developmental growth relationship: positively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048640 name: negative regulation of developmental growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] synonym: "down regulation of developmental growth" EXACT [] synonym: "down-regulation of developmental growth" EXACT [] synonym: "downregulation of developmental growth" EXACT [] synonym: "inhibition of developmental growth" NARROW [] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048589 ! developmental growth relationship: negatively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl subset: goslim_generic synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048666 name: neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030182 ! neuron differentiation [Term] id: GO:0048699 name: generation of neurons namespace: biological_process def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] synonym: "neuron generation" EXACT [] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] subset: goslim_mouse is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0040011 ! locomotion relationship: part_of GO:0051674 ! localization of cell [Term] id: GO:0048872 name: homeostasis of number of cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] synonym: "cell population homeostasis" EXACT [] synonym: "homeostasis of cell number" EXACT [GOC:dph] is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048878 name: chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete] subset: goslim_drosophila is_a: GO:0042592 ! homeostatic process [Term] id: GO:0050673 name: epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0050678 name: regulation of epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050673 ! epithelial cell proliferation relationship: regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "activation of epithelial cell proliferation" NARROW [] synonym: "stimulation of epithelial cell proliferation" NARROW [] synonym: "up regulation of epithelial cell proliferation" EXACT [] synonym: "up-regulation of epithelial cell proliferation" EXACT [] synonym: "upregulation of epithelial cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050673 ! epithelial cell proliferation relationship: positively_regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050680 name: negative regulation of epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "down regulation of epithelial cell proliferation" EXACT [] synonym: "down-regulation of epithelial cell proliferation" EXACT [] synonym: "downregulation of epithelial cell proliferation" EXACT [] synonym: "inhibition of epithelial cell proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050673 ! epithelial cell proliferation relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050708 name: regulation of protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009306 ! protein secretion relationship: regulates GO:0009306 ! protein secretion [Term] id: GO:0050709 name: negative regulation of protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "down regulation of protein secretion" EXACT [] synonym: "down-regulation of protein secretion" EXACT [] synonym: "downregulation of protein secretion" EXACT [] synonym: "inhibition of protein secretion" NARROW [] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009306 ! protein secretion relationship: negatively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050714 name: positive regulation of protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "activation of protein secretion" NARROW [] synonym: "stimulation of protein secretion" NARROW [] synonym: "up regulation of protein secretion" EXACT [] synonym: "up-regulation of protein secretion" EXACT [] synonym: "upregulation of protein secretion" EXACT [] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009306 ! protein secretion relationship: positively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050727 name: regulation of inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006954 ! inflammatory response relationship: regulates GO:0006954 ! inflammatory response [Term] id: GO:0050728 name: negative regulation of inflammatory response namespace: biological_process alt_id: GO:0030236 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "anti-inflammatory response" EXACT [] synonym: "down regulation of inflammatory response" EXACT [] synonym: "down-regulation of inflammatory response" EXACT [] synonym: "downregulation of inflammatory response" EXACT [] synonym: "inhibition of inflammatory response" NARROW [] is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006954 ! inflammatory response relationship: negatively_regulates GO:0006954 ! inflammatory response [Term] id: GO:0050729 name: positive regulation of inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "activation of inflammatory response" NARROW [] synonym: "stimulation of inflammatory response" NARROW [] synonym: "up regulation of inflammatory response" EXACT [] synonym: "up-regulation of inflammatory response" EXACT [] synonym: "upregulation of inflammatory response" EXACT [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006954 ! inflammatory response relationship: positively_regulates GO:0006954 ! inflammatory response [Term] id: GO:0050767 name: regulation of neurogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022008 ! neurogenesis relationship: part_of GO:0048699 ! generation of neurons relationship: regulates GO:0022008 ! neurogenesis [Term] id: GO:0050768 name: negative regulation of neurogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "down regulation of neurogenesis" EXACT [] synonym: "down-regulation of neurogenesis" EXACT [] synonym: "downregulation of neurogenesis" EXACT [] synonym: "inhibition of neurogenesis" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022008 ! neurogenesis relationship: negatively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050769 name: positive regulation of neurogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "activation of neurogenesis" NARROW [] synonym: "stimulation of neurogenesis" NARROW [] synonym: "up regulation of neurogenesis" EXACT [] synonym: "up-regulation of neurogenesis" EXACT [] synonym: "upregulation of neurogenesis" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051962 ! positive regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022008 ! neurogenesis relationship: positively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050776 name: regulation of immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006955 ! immune response relationship: regulates GO:0006955 ! immune response [Term] id: GO:0050777 name: negative regulation of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "down regulation of immune response" EXACT [] synonym: "down-regulation of immune response" EXACT [] synonym: "downregulation of immune response" EXACT [] synonym: "inhibition of immune response" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006955 ! immune response relationship: negatively_regulates GO:0006955 ! immune response [Term] id: GO:0050778 name: positive regulation of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "stimulation of immune response" NARROW [] synonym: "up regulation of immune response" EXACT [] synonym: "up-regulation of immune response" EXACT [] synonym: "upregulation of immune response" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006955 ! immune response relationship: positively_regulates GO:0006955 ! immune response [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process alt_id: GO:0048552 def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: goslim_chembl synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] xref: MIPS_funcat:18.02.01 is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003824 ! catalytic activity relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032502 ! developmental process relationship: regulates GO:0032502 ! developmental process [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009987 ! cellular process relationship: regulates GO:0009987 ! cellular process [Term] id: GO:0050795 name: regulation of behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] synonym: "regulation of behaviour" EXACT [] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007610 ! behavior relationship: regulates GO:0007610 ! behavior [Term] id: GO:0050801 name: ion homeostasis namespace: biological_process alt_id: GO:2000021 def: "Any process involved in the maintenance of an internal steady state of ions within an organism or cell." [GOC:ai] synonym: "electrolyte homeostasis" RELATED [] synonym: "negative regulation of crystal formation" RELATED [] synonym: "regulation of ion homeostasis" RELATED [] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0050802 name: circadian sleep/wake cycle, sleep namespace: biological_process def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai] is_a: GO:0022410 ! circadian sleep/wake cycle process is_a: GO:0030431 ! sleep intersection_of: GO:0030431 ! sleep intersection_of: part_of GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0050817 name: coagulation namespace: biological_process def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732] subset: goslim_pir synonym: "clotting" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0050818 name: regulation of coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai] synonym: "regulation of clotting" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050817 ! coagulation relationship: regulates GO:0050817 ! coagulation [Term] id: GO:0050819 name: negative regulation of coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai] synonym: "anticoagulant activity" RELATED [] synonym: "down regulation of coagulation" EXACT [] synonym: "down-regulation of coagulation" EXACT [] synonym: "downregulation of coagulation" EXACT [] synonym: "inhibition of coagulation" NARROW [] synonym: "negative regulation of clotting" EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050817 ! coagulation relationship: negatively_regulates GO:0050817 ! coagulation [Term] id: GO:0050820 name: positive regulation of coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai] synonym: "activation of coagulation" NARROW [] synonym: "positive regulation of clotting" EXACT [] synonym: "stimulation of coagulation" NARROW [] synonym: "up regulation of coagulation" EXACT [] synonym: "up-regulation of coagulation" EXACT [] synonym: "upregulation of coagulation" EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050817 ! coagulation relationship: positively_regulates GO:0050817 ! coagulation [Term] id: GO:0050865 name: regulation of cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001775 ! cell activation relationship: regulates GO:0001775 ! cell activation [Term] id: GO:0050866 name: negative regulation of cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai] synonym: "down regulation of cell activation" EXACT [] synonym: "down-regulation of cell activation" EXACT [] synonym: "downregulation of cell activation" EXACT [] synonym: "inhibition of cell activation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001775 ! cell activation relationship: negatively_regulates GO:0001775 ! cell activation [Term] id: GO:0050867 name: positive regulation of cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] synonym: "activation of cell activation" NARROW [] synonym: "stimulation of cell activation" NARROW [] synonym: "up regulation of cell activation" EXACT [] synonym: "up-regulation of cell activation" EXACT [] synonym: "upregulation of cell activation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001775 ! cell activation relationship: positively_regulates GO:0001775 ! cell activation [Term] id: GO:0050877 name: nervous system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "neurological system process" EXACT [] synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] is_a: GO:0003008 ! system process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13824 xsd:anyURI [Term] id: GO:0050878 name: regulation of body fluid levels namespace: biological_process def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_pir is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050890 name: cognition namespace: biological_process def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908] subset: goslim_drosophila xref: Wikipedia:Cognition is_a: GO:0050877 ! nervous system process [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "physiological response to stimulus" EXACT [] xref: MIPS_funcat:34.11 is_a: GO:0008150 ! biological_process [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception namespace: biological_process def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph] synonym: "sensory detection of stimulus" EXACT [] synonym: "sensory perception, sensory transduction of stimulus" EXACT [] synonym: "sensory perception, stimulus detection" EXACT [] synonym: "sensory transduction" EXACT [] xref: Wikipedia:Transduction_(physiology) is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0007600 ! sensory perception [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception namespace: biological_process def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "sensory detection of light during visual perception" EXACT [] synonym: "sensory detection of light stimulus during visual perception" EXACT [] synonym: "sensory transduction of light during visual perception" EXACT [] synonym: "sensory transduction of light stimulus during visual perception" EXACT [] synonym: "visual perception, detection of light stimulus" EXACT [] synonym: "visual perception, sensory transduction during perception of light" EXACT [] synonym: "visual perception, sensory transduction of light stimulus" EXACT [] is_a: GO:0009584 ! detection of visible light is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007601 ! visual perception relationship: part_of GO:0007601 ! visual perception [Term] id: GO:0050909 name: sensory perception of taste namespace: biological_process def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai] synonym: "gustation" EXACT [] synonym: "sense of taste" EXACT [] synonym: "taste" EXACT [] synonym: "taste perception" EXACT [] xref: Wikipedia:Taste is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050913 name: sensory perception of bitter taste namespace: biological_process def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "bitter taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050953 name: sensory perception of light stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050954 name: sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanosensory perception" EXACT [] synonym: "perception of mechanical stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] synonym: "sensory detection of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of light stimulus" EXACT [] synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0051037 name: regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:go_curators] synonym: "meiotic regulation of transcription" EXACT [] synonym: "regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0022414 ! reproductive process intersection_of: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051038 name: negative regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle." [GOC:ai] synonym: "down regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "down-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "downregulation of transcription during meiosis" EXACT [GOC:mah] synonym: "inhibition of transcription during meiosis" NARROW [GOC:mah] synonym: "meiotic repression of transcription" EXACT [] synonym: "negative regulation of meiotic transcription" EXACT [] synonym: "negative regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051039 name: positive regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:ai] synonym: "activation of transcription during meiosis" NARROW [GOC:mah] synonym: "positive regulation of meiotic transcription" EXACT [] synonym: "positive regulation of transcription, meiotic" EXACT [GOC:mah] synonym: "stimulation of transcription during meiosis" NARROW [GOC:mah] synonym: "up regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "up-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "upregulation of transcription during meiosis" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051046 name: regulation of secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046903 ! secretion relationship: regulates GO:0046903 ! secretion [Term] id: GO:0051047 name: positive regulation of secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "activation of secretion" NARROW [] synonym: "stimulation of secretion" NARROW [] synonym: "up regulation of secretion" EXACT [] synonym: "up-regulation of secretion" EXACT [] synonym: "upregulation of secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046903 ! secretion relationship: positively_regulates GO:0046903 ! secretion [Term] id: GO:0051048 name: negative regulation of secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "down regulation of secretion" EXACT [] synonym: "down-regulation of secretion" EXACT [] synonym: "downregulation of secretion" EXACT [] synonym: "inhibition of secretion" NARROW [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046903 ! secretion relationship: negatively_regulates GO:0046903 ! secretion [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_yeast is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006810 ! transport relationship: regulates GO:0006810 ! transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006810 ! transport relationship: positively_regulates GO:0006810 ! transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006810 ! transport relationship: negatively_regulates GO:0006810 ! transport [Term] id: GO:0051052 name: regulation of DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: goslim_yeast synonym: "regulation of DNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006259 ! DNA metabolic process relationship: regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051053 name: negative regulation of DNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "down regulation of DNA metabolic process" EXACT [] synonym: "down-regulation of DNA metabolic process" EXACT [] synonym: "downregulation of DNA metabolic process" EXACT [] synonym: "inhibition of DNA metabolic process" NARROW [] synonym: "negative regulation of DNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006259 ! DNA metabolic process relationship: negatively_regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051054 name: positive regulation of DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "activation of DNA metabolic process" NARROW [] synonym: "positive regulation of DNA metabolism" EXACT [] synonym: "stimulation of DNA metabolic process" NARROW [] synonym: "up regulation of DNA metabolic process" EXACT [] synonym: "up-regulation of DNA metabolic process" EXACT [] synonym: "upregulation of DNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006259 ! DNA metabolic process relationship: positively_regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051093 name: negative regulation of developmental process namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "down regulation of developmental process" EXACT [] synonym: "down-regulation of developmental process" EXACT [] synonym: "downregulation of developmental process" EXACT [] synonym: "inhibition of developmental process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032502 ! developmental process relationship: negatively_regulates GO:0032502 ! developmental process [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032502 ! developmental process relationship: positively_regulates GO:0032502 ! developmental process [Term] id: GO:0051098 name: regulation of binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005488 ! binding relationship: regulates GO:0005488 ! binding [Term] id: GO:0051099 name: positive regulation of binding namespace: biological_process def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] synonym: "activation of binding" NARROW [] synonym: "stimulation of binding" NARROW [] synonym: "up regulation of binding" EXACT [] synonym: "up-regulation of binding" EXACT [] synonym: "upregulation of binding" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005488 ! binding relationship: positively_regulates GO:0005488 ! binding [Term] id: GO:0051100 name: negative regulation of binding namespace: biological_process def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] synonym: "down regulation of binding" EXACT [] synonym: "down-regulation of binding" EXACT [] synonym: "downregulation of binding" EXACT [] synonym: "inhibition of binding" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005488 ! binding relationship: negatively_regulates GO:0005488 ! binding [Term] id: GO:0051101 name: regulation of DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003677 ! DNA binding relationship: regulates GO:0003677 ! DNA binding [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016043 ! cellular component organization relationship: regulates GO:0016043 ! cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016043 ! cellular component organization relationship: negatively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016043 ! cellular component organization relationship: positively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "regulation of nitrogen metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006807 ! nitrogen compound metabolic process relationship: regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051172 name: negative regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "down regulation of nitrogen metabolic process" EXACT [] synonym: "down-regulation of nitrogen metabolic process" EXACT [] synonym: "downregulation of nitrogen metabolic process" EXACT [] synonym: "inhibition of nitrogen metabolic process" NARROW [] synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "negative regulation of nitrogen metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "activation of nitrogen metabolic process" NARROW [] synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "positive regulation of nitrogen metabolism" EXACT [] synonym: "stimulation of nitrogen metabolic process" NARROW [] synonym: "up regulation of nitrogen metabolic process" EXACT [] synonym: "up-regulation of nitrogen metabolic process" EXACT [] synonym: "upregulation of nitrogen metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006793 ! phosphorus metabolic process relationship: regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0051175 name: negative regulation of sulfur metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] synonym: "down regulation of sulfur metabolic process" EXACT [] synonym: "down-regulation of sulfur metabolic process" EXACT [] synonym: "downregulation of sulfur metabolic process" EXACT [] synonym: "inhibition of sulfur metabolic process" NARROW [] synonym: "negative regulation of sulfur metabolism" EXACT [] synonym: "negative regulation of sulphur metabolic process" EXACT [] synonym: "negative regulation of sulphur metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006790 ! sulfur compound metabolic process relationship: negatively_regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051176 name: positive regulation of sulfur metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] synonym: "activation of sulfur metabolic process" NARROW [] synonym: "positive regulation of sulfur metabolism" EXACT [] synonym: "positive regulation of sulphur metabolic process" EXACT [] synonym: "positive regulation of sulphur metabolism" EXACT [] synonym: "stimulation of sulfur metabolic process" NARROW [] synonym: "up regulation of sulfur metabolic process" EXACT [] synonym: "up-regulation of sulfur metabolic process" EXACT [] synonym: "upregulation of sulfur metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006790 ! sulfur compound metabolic process relationship: positively_regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051179 name: localization namespace: biological_process alt_id: GO:1902578 def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] subset: goslim_pir synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] synonym: "single organism localization" RELATED [GOC:TermGenie] synonym: "single-organism localization" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2013-12-18T13:51:04Z [Term] id: GO:0051180 name: vitamin transport namespace: biological_process def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_pir synonym: "vitamin or cofactor transport" BROAD [] is_a: GO:0006810 ! transport [Term] id: GO:0051181 name: cofactor transport namespace: biological_process def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: goslim_pir synonym: "vitamin or cofactor transport" BROAD [] is_a: GO:0006810 ! transport [Term] id: GO:0051186 name: cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "cofactor metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0051193 name: regulation of cofactor metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] synonym: "regulation of cofactor metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051186 ! cofactor metabolic process relationship: regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051194 name: positive regulation of cofactor metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] synonym: "activation of cofactor metabolic process" NARROW [] synonym: "positive regulation of cofactor metabolism" EXACT [] synonym: "stimulation of cofactor metabolic process" NARROW [] synonym: "up regulation of cofactor metabolic process" EXACT [] synonym: "up-regulation of cofactor metabolic process" EXACT [] synonym: "upregulation of cofactor metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051186 ! cofactor metabolic process relationship: positively_regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051195 name: negative regulation of cofactor metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] synonym: "down regulation of cofactor metabolic process" EXACT [] synonym: "down-regulation of cofactor metabolic process" EXACT [] synonym: "downregulation of cofactor metabolic process" EXACT [] synonym: "inhibition of cofactor metabolic process" NARROW [] synonym: "negative regulation of cofactor metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051186 ! cofactor metabolic process relationship: negatively_regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051196 name: regulation of coenzyme metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "regulation of coenzyme metabolism" EXACT [] is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006732 ! coenzyme metabolic process relationship: regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051197 name: positive regulation of coenzyme metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] synonym: "activation of coenzyme metabolic process" NARROW [] synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "positive regulation of coenzyme metabolism" EXACT [] synonym: "stimulation of coenzyme metabolic process" NARROW [] synonym: "up regulation of coenzyme metabolic process" EXACT [] synonym: "up-regulation of coenzyme metabolic process" EXACT [] synonym: "upregulation of coenzyme metabolic process" EXACT [] is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006732 ! coenzyme metabolic process relationship: positively_regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051198 name: negative regulation of coenzyme metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] synonym: "down regulation of coenzyme metabolic process" EXACT [] synonym: "down-regulation of coenzyme metabolic process" EXACT [] synonym: "downregulation of coenzyme metabolic process" EXACT [] synonym: "inhibition of coenzyme metabolic process" NARROW [] synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "negative regulation of coenzyme metabolism" EXACT [] is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006732 ! coenzyme metabolic process relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015031 ! protein transport relationship: positively_regulates GO:0015031 ! protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015031 ! protein transport relationship: regulates GO:0015031 ! protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015031 ! protein transport relationship: negatively_regulates GO:0015031 ! protein transport [Term] id: GO:0051225 name: spindle assembly namespace: biological_process alt_id: GO:0051226 alt_id: GO:0051227 def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] synonym: "bipolar spindle biosynthesis" EXACT [] synonym: "bipolar spindle formation" EXACT [] synonym: "spindle biosynthesis" EXACT [] synonym: "spindle formation" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0070925 ! organelle assembly [Term] id: GO:0051231 name: spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007051 ! spindle organization relationship: part_of GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0051232 name: meiotic spindle elongation namespace: biological_process def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai] synonym: "spindle elongation during meiosis" EXACT [] is_a: GO:0051231 ! spindle elongation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051231 ! spindle elongation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0000212 ! meiotic spindle organization relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0051239 name: regulation of multicellular organismal process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032501 ! multicellular organismal process relationship: regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051240 name: positive regulation of multicellular organismal process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "activation of multicellular organismal process" NARROW [] synonym: "stimulation of multicellular organismal process" NARROW [] synonym: "up regulation of multicellular organismal process" EXACT [] synonym: "up-regulation of multicellular organismal process" EXACT [] synonym: "upregulation of multicellular organismal process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032501 ! multicellular organismal process relationship: positively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "down regulation of multicellular organismal process" EXACT [] synonym: "down-regulation of multicellular organismal process" EXACT [] synonym: "downregulation of multicellular organismal process" EXACT [] synonym: "inhibition of multicellular organismal process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032501 ! multicellular organismal process relationship: negatively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051245 name: negative regulation of cellular defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai] synonym: "down regulation of cellular defense response" EXACT [] synonym: "down-regulation of cellular defense response" EXACT [] synonym: "downregulation of cellular defense response" EXACT [] synonym: "inhibition of cellular defense response" NARROW [] synonym: "negative regulation of cellular defence response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031348 ! negative regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006968 ! cellular defense response relationship: negatively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019538 ! protein metabolic process relationship: regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019538 ! protein metabolic process relationship: positively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019538 ! protein metabolic process relationship: negatively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051249 name: regulation of lymphocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046649 ! lymphocyte activation relationship: regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051250 name: negative regulation of lymphocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "down regulation of lymphocyte activation" EXACT [] synonym: "down-regulation of lymphocyte activation" EXACT [] synonym: "downregulation of lymphocyte activation" EXACT [] synonym: "inhibition of lymphocyte activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046649 ! lymphocyte activation relationship: negatively_regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051251 name: positive regulation of lymphocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "activation of lymphocyte activation" NARROW [] synonym: "stimulation of lymphocyte activation" NARROW [] synonym: "up regulation of lymphocyte activation" EXACT [] synonym: "up-regulation of lymphocyte activation" EXACT [] synonym: "upregulation of lymphocyte activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046649 ! lymphocyte activation relationship: positively_regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016070 ! RNA metabolic process relationship: regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016070 ! RNA metabolic process relationship: negatively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016070 ! RNA metabolic process relationship: positively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051270 name: regulation of cellular component movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "regulation of cell movement" RELATED [] synonym: "regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006928 ! movement of cell or subcellular component relationship: regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051271 name: negative regulation of cellular component movement namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "negative regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006928 ! movement of cell or subcellular component relationship: negatively_regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051272 name: positive regulation of cellular component movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "positive regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006928 ! movement of cell or subcellular component relationship: positively_regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0009987 ! cellular process [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051301 ! cell division relationship: regulates GO:0051301 ! cell division [Term] id: GO:0051318 name: G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:G1_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051319 name: G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:G2_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051320 name: S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S-phase" EXACT [] xref: Wikipedia:S_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process alt_id: GO:0007126 def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] subset: goslim_drosophila subset: goslim_yeast synonym: "meiosis" RELATED [] xref: Wikipedia:Meiosis is_a: GO:0007049 ! cell cycle is_a: GO:0022414 ! reproductive process intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140013 ! meiotic nuclear division relationship: has_part GO:0140013 ! meiotic nuclear division [Term] id: GO:0051322 name: anaphase namespace: biological_process def: "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Anaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051323 name: metaphase namespace: biological_process def: "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Metaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051324 name: prophase namespace: biological_process def: "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Prophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051325 name: interphase namespace: biological_process def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "karyostasis" EXACT [] synonym: "resting phase" BROAD [] xref: Wikipedia:Interphase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0051326 name: telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Telophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051327 name: meiotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of meiotic cell cycle" EXACT [] is_a: GO:0000279 ! M phase is_a: GO:0098762 ! meiotic cell cycle phase intersection_of: GO:0000279 ! M phase intersection_of: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0051328 name: meiotic interphase namespace: biological_process def: "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "interphase of meiotic cell cycle" EXACT [] is_a: GO:0051325 ! interphase is_a: GO:0098762 ! meiotic cell cycle phase intersection_of: GO:0051325 ! interphase intersection_of: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0051329 name: mitotic interphase namespace: biological_process def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "interphase of mitotic cell cycle" EXACT [] is_a: GO:0051325 ! interphase is_a: GO:0098763 ! mitotic cell cycle phase intersection_of: GO:0051325 ! interphase intersection_of: happens_during GO:0000278 ! mitotic cell cycle [Term] id: GO:0051330 name: meiotic G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G1 phase of meiotic cell cycle" EXACT [] is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051328 ! meiotic interphase [Term] id: GO:0051331 name: meiotic G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G2 phase of meiotic cell cycle" EXACT [] is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051328 ! meiotic interphase [Term] id: GO:0051332 name: meiotic S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S phase of meiotic cell cycle" EXACT [] synonym: "S-phase of meiotic cell cycle" EXACT [] is_a: GO:0051320 ! S phase relationship: part_of GO:0051328 ! meiotic interphase [Term] id: GO:0051336 name: regulation of hydrolase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai] synonym: "hydrolase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016787 ! hydrolase activity relationship: regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016740 ! transferase activity relationship: regulates GO:0016740 ! transferase activity [Term] id: GO:0051340 name: regulation of ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai] synonym: "ligase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016874 ! ligase activity relationship: regulates GO:0016874 ! ligase activity [Term] id: GO:0051345 name: positive regulation of hydrolase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] synonym: "activation of hydrolase activity" NARROW [] synonym: "hydrolase activator" EXACT [] synonym: "stimulation of hydrolase activity" NARROW [] synonym: "up regulation of hydrolase activity" EXACT [] synonym: "up-regulation of hydrolase activity" EXACT [] synonym: "upregulation of hydrolase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016787 ! hydrolase activity relationship: positively_regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051346 name: negative regulation of hydrolase activity namespace: biological_process def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] synonym: "down regulation of hydrolase activity" EXACT [] synonym: "down-regulation of hydrolase activity" EXACT [] synonym: "downregulation of hydrolase activity" EXACT [] synonym: "hydrolase inhibitor" EXACT [] synonym: "inhibition of hydrolase activity" NARROW [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016787 ! hydrolase activity relationship: negatively_regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051347 name: positive regulation of transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "activation of transferase activity" NARROW [] synonym: "stimulation of transferase activity" NARROW [] synonym: "transferase activator" EXACT [] synonym: "up regulation of transferase activity" EXACT [] synonym: "up-regulation of transferase activity" EXACT [] synonym: "upregulation of transferase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016740 ! transferase activity relationship: positively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051348 name: negative regulation of transferase activity namespace: biological_process def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "down regulation of transferase activity" EXACT [] synonym: "down-regulation of transferase activity" EXACT [] synonym: "downregulation of transferase activity" EXACT [] synonym: "inhibition of transferase activity" NARROW [] synonym: "transferase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016740 ! transferase activity relationship: negatively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051351 name: positive regulation of ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] synonym: "activation of ligase activity" NARROW [] synonym: "ligase activator" EXACT [] synonym: "stimulation of ligase activity" NARROW [] synonym: "up regulation of ligase activity" EXACT [] synonym: "up-regulation of ligase activity" EXACT [] synonym: "upregulation of ligase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016874 ! ligase activity relationship: positively_regulates GO:0016874 ! ligase activity [Term] id: GO:0051352 name: negative regulation of ligase activity namespace: biological_process def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] synonym: "down regulation of ligase activity" EXACT [] synonym: "down-regulation of ligase activity" EXACT [] synonym: "downregulation of ligase activity" EXACT [] synonym: "inhibition of ligase activity" NARROW [] synonym: "ligase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016874 ! ligase activity relationship: negatively_regulates GO:0016874 ! ligase activity [Term] id: GO:0051384 name: response to glucocorticoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123] synonym: "response to glucocorticoid stimulus" EXACT [GOC:dos] is_a: GO:0031960 ! response to corticosteroid [Term] id: GO:0051427 name: hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for hormones." [GOC:ai] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051321 ! meiotic cell cycle relationship: regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051321 ! meiotic cell cycle relationship: positively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051321 ! meiotic cell cycle relationship: negatively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051493 name: regulation of cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007010 ! cytoskeleton organization relationship: regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051494 name: negative regulation of cytoskeleton organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "down regulation of cytoskeleton organization" EXACT [] synonym: "down-regulation of cytoskeleton organization" EXACT [] synonym: "downregulation of cytoskeleton organization" EXACT [] synonym: "inhibition of cytoskeleton organization" NARROW [] synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007010 ! cytoskeleton organization relationship: negatively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051495 name: positive regulation of cytoskeleton organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "activation of cytoskeleton organization" NARROW [] synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cytoskeleton organization" NARROW [] synonym: "up regulation of cytoskeleton organization" EXACT [] synonym: "up-regulation of cytoskeleton organization" EXACT [] synonym: "upregulation of cytoskeleton organization" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007010 ! cytoskeleton organization relationship: positively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051560 name: mitochondrial calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in mitochondria" EXACT [] synonym: "calcium ion homeostasis in mitochondrion" EXACT [] synonym: "mitochondrial calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in mitochondria" EXACT [] synonym: "regulation of calcium ion concentration in mitochondrion" EXACT [] synonym: "regulation of mitochondrial calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0051563 name: smooth endoplasmic reticulum calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT [] synonym: "calcium ion homeostasis in smooth ER" EXACT [] synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] synonym: "regulation of calcium ion concentration in smooth ER" EXACT [] synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "regulation of smooth ER calcium ion concentration" EXACT [] synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT [] synonym: "smooth ER calcium ion concentration regulation" EXACT [] synonym: "smooth ER calcium ion homeostasis" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005790 ! smooth endoplasmic reticulum relationship: occurs_in GO:0005790 ! smooth endoplasmic reticulum [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization [Term] id: GO:0051641 name: cellular localization namespace: biological_process alt_id: GO:1902580 def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] subset: goslim_pir synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] synonym: "single-organism cellular localization" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization created_by: jl creation_date: 2013-12-18T14:04:32Z [Term] id: GO:0051646 name: mitochondrion localization namespace: biological_process def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of mitochondria localization" EXACT [] synonym: "establishment and maintenance of mitochondrion localization" EXACT [] synonym: "localization of mitochondria" EXACT [] synonym: "localization of mitochondrion" EXACT [] synonym: "mitochondria localization" EXACT [] synonym: "mitochondrial localization" EXACT [] synonym: "mitochondrion localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] subset: goslim_aspergillus synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: occurs_in GO:0016020 ! membrane relationship: occurs_in GO:0016020 ! membrane [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization [Term] id: GO:0051701 name: interaction with host namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] is_a: GO:0044403 ! symbiotic process [Term] id: GO:0051703 name: intraspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai] subset: goslim_pir synonym: "intraspecies interaction with other organisms" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051704 name: multi-organism process namespace: biological_process alt_id: GO:0051706 def: "A biological process which involves another organism of the same or different species." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "interaction between organisms" EXACT [] synonym: "physiological interaction between organisms" EXACT [] synonym: "physiological interaction with other organism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051705 name: multi-organism behavior name: obsolete multi-organism behavior namespace: biological_process def: "OBSOLETE. Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai] comment: This term was obsoleted because it was an unnecessary grouping term. subset: goslim_pir synonym: "behavioral interaction between organisms" EXACT [] synonym: "behavioral interaction with other organism" EXACT [] synonym: "behavioral signaling" NARROW [] synonym: "behavioral signalling" NARROW [GOC:mah] synonym: "behavioural interaction between organisms" EXACT [] synonym: "behavioural interaction with other organism" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0051704 ! multi-organism process property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18810 xsd:anyURI is_obsolete: true [Term] id: GO:0051707 name: response to other organism namespace: biological_process alt_id: GO:0009613 alt_id: GO:0042828 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0051709 name: regulation of killing of cells of other organism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] synonym: "regulation of killing of cells of another organism" EXACT [GOC:bf] is_a: GO:0031341 ! regulation of cell killing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031640 ! killing of cells of other organism relationship: regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051711 name: negative regulation of killing of cells of other organism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] synonym: "down regulation of killing of cells of another organism" EXACT [] synonym: "down-regulation of killing of cells of another organism" EXACT [] synonym: "downregulation of killing of cells of another organism" EXACT [] synonym: "inhibition of killing of cells of another organism" NARROW [] synonym: "negative regulation of killing of cells of another organism" EXACT [GOC:bf] is_a: GO:0031342 ! negative regulation of cell killing is_a: GO:0051709 ! regulation of killing of cells of other organism intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031640 ! killing of cells of other organism relationship: negatively_regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051712 name: positive regulation of killing of cells of other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] synonym: "activation of killing of cells of another organism" NARROW [] synonym: "stimulation of killing of cells of another organism" NARROW [] synonym: "up regulation of killing of cells of another organism" EXACT [] synonym: "up-regulation of killing of cells of another organism" EXACT [] synonym: "upregulation of killing of cells of another organism" EXACT [] is_a: GO:0031343 ! positive regulation of cell killing is_a: GO:0051709 ! regulation of killing of cells of other organism intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031640 ! killing of cells of other organism relationship: positively_regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007049 ! cell cycle relationship: regulates GO:0007049 ! cell cycle [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051301 ! cell division relationship: positively_regulates GO:0051301 ! cell division [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051301 ! cell division relationship: negatively_regulates GO:0051301 ! cell division [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000280 ! nuclear division relationship: regulates GO:0000280 ! nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000280 ! nuclear division relationship: negatively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000280 ! nuclear division relationship: positively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051817 name: modulation of process of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "modification of morphology or physiology of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modification of morphology or physiology of other organism involved in symbiotic interaction" RELATED [] synonym: "modulation of biological process of other organism involved in symbiotic interaction" RELATED [] synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] synonym: "regulation of morphology of other organism during symbiotic interaction" NARROW [] synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] synonym: "regulation of physiological process in other organism during symbiotic interaction" NARROW [] synonym: "regulation of physiology of other organism during symbiotic interaction" NARROW [] is_a: GO:0035821 ! modulation of process of other organism property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18605 xsd:anyURI [Term] id: GO:0051818 name: disruption of cells of other organism involved in symbiotic interaction namespace: biological_process def: "A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "disruption of cells of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0044364 ! disruption of cells of other organism is_a: GO:0051817 ! modulation of process of other organism involved in symbiotic interaction [Term] id: GO:0051883 name: killing of cells in other organism involved in symbiotic interaction namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0031640 ! killing of cells of other organism is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0051930 name: regulation of sensory perception of pain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019233 ! sensory perception of pain relationship: regulates GO:0019233 ! sensory perception of pain [Term] id: GO:0051931 name: regulation of sensory perception namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007600 ! sensory perception relationship: regulates GO:0007600 ! sensory perception [Term] id: GO:0051960 name: regulation of nervous system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007399 ! nervous system development relationship: regulates GO:0007399 ! nervous system development [Term] id: GO:0051961 name: negative regulation of nervous system development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "down regulation of nervous system development" EXACT [] synonym: "down-regulation of nervous system development" EXACT [] synonym: "downregulation of nervous system development" EXACT [] synonym: "inhibition of nervous system development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007399 ! nervous system development relationship: negatively_regulates GO:0007399 ! nervous system development [Term] id: GO:0051962 name: positive regulation of nervous system development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "activation of nervous system development" NARROW [] synonym: "stimulation of nervous system development" NARROW [] synonym: "up regulation of nervous system development" EXACT [] synonym: "up-regulation of nervous system development" EXACT [] synonym: "upregulation of nervous system development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007399 ! nervous system development relationship: positively_regulates GO:0007399 ! nervous system development [Term] id: GO:0051983 name: regulation of chromosome segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007059 ! chromosome segregation relationship: regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051984 name: positive regulation of chromosome segregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "activation of chromosome segregation" NARROW [] synonym: "stimulation of chromosome segregation" NARROW [] synonym: "up regulation of chromosome segregation" EXACT [] synonym: "up-regulation of chromosome segregation" EXACT [] synonym: "upregulation of chromosome segregation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007059 ! chromosome segregation relationship: positively_regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051985 name: negative regulation of chromosome segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "down regulation of chromosome segregation" EXACT [] synonym: "down-regulation of chromosome segregation" EXACT [] synonym: "downregulation of chromosome segregation" EXACT [] synonym: "inhibition of chromosome segregation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007059 ! chromosome segregation relationship: negatively_regulates GO:0007059 ! chromosome segregation [Term] id: GO:0052038 name: modulation by symbiont of host intracellular transport namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of host intracellular trafficking" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052230 ! modulation of intracellular transport in other organism involved in symbiotic interaction intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0046907 ! intracellular transport [Term] id: GO:0052040 name: modulation by symbiont of host programmed cell death namespace: biological_process alt_id: GO:0052152 def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by symbiont of host non-apoptotic programmed cell death" NARROW [] synonym: "modulation of host PCD" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0012501 ! programmed cell death [Term] id: GO:0052041 name: negative regulation by symbiont of host programmed cell death namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host programmed cell death" EXACT [] synonym: "down-regulation by symbiont of host programmed cell death" EXACT [] synonym: "downregulation by symbiont of host programmed cell death" EXACT [] synonym: "inhibition by symbiont of host programmed cell death" NARROW [] synonym: "inhibition of host programmed cell death" EXACT [] synonym: "suppression by symbiont of host PCD" EXACT [] synonym: "suppression by symbiont of host programmed cell death" EXACT [] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0052040 ! modulation by symbiont of host programmed cell death intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: negatively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0052042 name: positive regulation by symbiont of host programmed cell death namespace: biological_process alt_id: GO:0012504 alt_id: GO:0052044 alt_id: GO:0052045 alt_id: GO:0052153 alt_id: GO:0052397 alt_id: GO:0052400 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] synonym: "activation by organism of host programmed cell death" EXACT [] synonym: "activation by organism of non-apoptotic programmed cell death in other organism" NARROW [] synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] synonym: "activation by symbiont of host programmed cell death" NARROW [] synonym: "enhancement of host programmed cell death" EXACT [] synonym: "enhancement of host programmed cell death by organism" EXACT [] synonym: "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "induction by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT [] synonym: "induction by symbiont of host programmed cell death" EXACT [] synonym: "induction of non-apoptotic programmed cell death by other organism" RELATED [] synonym: "positive regulation by symbiont of host non-apoptotic programmed cell death" NARROW [] synonym: "stimulation by symbiont of host programmed cell death" NARROW [] synonym: "upregulation by symbiont of host programmed cell death" EXACT [] is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: positively_regulates GO:0012501 ! programmed cell death relationship: part_of GO:0001907 ! killing by symbiont of host cells [Term] id: GO:0052047 name: obsolete symbiotic process mediated by secreted substance namespace: biological_process def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it has been misused to annotate host proteins. synonym: "interaction with other organism via secreted substance during symbiotic interaction" RELATED [GOC:dph] synonym: "interaction with other organism via secreted substance involved in symbiotic interaction" RELATED [] is_obsolete: true [Term] id: GO:0052048 name: obsolete interaction with host via secreted substance namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. synonym: "interaction with host via secreted substance during symbiotic interaction" RELATED [GOC:dph] synonym: "interaction with host via secreted substance involved in symbiotic interaction" RELATED [] is_obsolete: true [Term] id: GO:0052053 name: negative regulation by symbiont of host catalytic activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host enzyme activity" EXACT [] synonym: "down-regulation by symbiont of host enzyme activity" EXACT [] synonym: "downregulation by symbiont of host enzyme activity" EXACT [] synonym: "inhibition by symbiont of host enzyme activity" NARROW [] synonym: "inhibition of host enzyme activity" EXACT [] synonym: "negative regulation by symbiont of host enzyme activity" EXACT [] is_a: GO:0052056 ! negative regulation by symbiont of host molecular function is_a: GO:0052148 ! modulation by symbiont of host catalytic activity is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0052054 name: negative regulation by symbiont of host peptidase activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by symbiont of host protease activity" NARROW [] synonym: "down-regulation by symbiont of host protease activity" NARROW [] synonym: "downregulation by symbiont of host protease activity" NARROW [] synonym: "inhibition by symbiont of host protease activity" NARROW [] synonym: "inhibition of host protease activity" NARROW [] synonym: "negative regulation by symbiont of host protease activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity is_a: GO:0052149 ! modulation by symbiont of host peptidase activity is_a: GO:0052180 ! negative regulation of peptidase activity in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: negatively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0052055 name: modulation by symbiont of host molecular function namespace: biological_process def: "The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modification by symbiont of host molecular function" EXACT [] synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0044003 ! modulation by symbiont of host process is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0003674 ! molecular_function [Term] id: GO:0052056 name: negative regulation by symbiont of host molecular function namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by symbiont of host protein function" EXACT [] synonym: "down-regulation by symbiont of host protein function" EXACT [] synonym: "downregulation by symbiont of host protein function" EXACT [] synonym: "inhibition by symbiont of host protein function" NARROW [] synonym: "inhibition of host protein function" EXACT [] synonym: "negative regulation by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0052055 ! modulation by symbiont of host molecular function is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: negatively_regulates GO:0003674 ! molecular_function [Term] id: GO:0052097 name: obsolete interspecies quorum sensing namespace: biological_process def: "OBSOLETE. The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that this term was an unnecessary grouping term. is_obsolete: true [Term] id: GO:0052100 name: obsolete intraspecies quorum sensing namespace: biological_process def: "OBSOLETE. The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that this term was an unnecessary grouping term. is_obsolete: true [Term] id: GO:0052106 name: obsolete quorum sensing involved in interaction with host namespace: biological_process def: "OBSOLETE. The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that this term was not clearly defined and usage was inconsistent. synonym: "quorum sensing during interaction with host" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0052128 name: positive energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] is_a: GO:0009453 ! energy taxis [Term] id: GO:0052129 name: negative energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] is_a: GO:0009453 ! energy taxis [Term] id: GO:0052148 name: modulation by symbiont of host catalytic activity namespace: biological_process def: "The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modulation by symbiont of host enzyme activity" EXACT [GOC:tb] synonym: "modulation of catalytic activity of host by symbiont" EXACT [] synonym: "regulation by symbiont of host catalytic activity" EXACT [] synonym: "regulation of catalytic activity of host by symbiont" EXACT [] synonym: "regulation of host catalytic activity by symbiont" EXACT [] is_a: GO:0052055 ! modulation by symbiont of host molecular function is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: regulates GO:0003824 ! catalytic activity [Term] id: GO:0052149 name: modulation by symbiont of host peptidase activity namespace: biological_process def: "The process in which an organism effects a change in host peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by symbiont of host protease activity" NARROW [GOC:bf] is_a: GO:0052148 ! modulation by symbiont of host catalytic activity is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: regulates GO:0008233 ! peptidase activity [Term] id: GO:0052150 name: modulation by symbiont of host apoptotic process namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'. synonym: "modulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "modulation by symbiont of host apoptosis" NARROW [] is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0052433 ! modulation by organism of apoptotic process in other organism involved in symbiotic interaction intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: regulates GO:0006915 ! apoptotic process [Term] id: GO:0052151 name: positive regulation by symbiont of host apoptotic process namespace: biological_process alt_id: GO:0033669 alt_id: GO:0052030 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'. synonym: "activation by organism of host apoptosis" EXACT [] synonym: "activation by organism of host apoptotic programmed cell death" EXACT [] synonym: "activation by symbiont of host apoptosis" NARROW [] synonym: "induction by organism of host apoptotic programmed cell death" EXACT [] synonym: "induction by symbiont of host apoptosis" EXACT [] synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "positive regulation by symbiont of host apoptosis" NARROW [] synonym: "stimulation by symbiont of host apoptosis" NARROW [] synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "up regulation by symbiont of host apoptosis" EXACT [] synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "up-regulation by symbiont of host apoptosis" EXACT [] synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "upregulation by symbiont of host apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death is_a: GO:0052150 ! modulation by symbiont of host apoptotic process intersection_of: GO:0044003 ! modulation by symbiont of host process intersection_of: positively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0052180 name: negative regulation of peptidase activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] is_a: GO:0035940 ! negative regulation of peptidase activity in other organism is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052198 name: modulation of peptidase activity in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of protease activity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of protease activity in other organism involved in symbiotic interaction" NARROW [GOC:bf] is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052199 name: negative regulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "inhibition of enzyme activity in other organism" EXACT [] synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction intersection_of: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction intersection_of: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0052203 name: modulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modulation of enzyme activity within other organism during symbiotic interaction" EXACT [GOC:tb] is_a: GO:0050790 ! regulation of catalytic activity is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052204 name: negative regulation of molecular function in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "inhibition of protein function in other organism" EXACT [] synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] is_a: GO:0044362 ! negative regulation of molecular function in other organism is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052205 name: modulation of molecular function in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modification of molecular function in other organism during symbiotic interaction" EXACT [] synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] synonym: "modulation of molecular function in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044359 ! modulation of molecular function in other organism is_a: GO:0051817 ! modulation of process of other organism involved in symbiotic interaction [Term] id: GO:0052230 name: modulation of intracellular transport in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of intracellular trafficking in other organism" EXACT [] synonym: "modulation of intracellular transport in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051817 ! modulation of process of other organism involved in symbiotic interaction [Term] id: GO:0052248 name: modulation of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0052459 def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "modulation of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044531 ! modulation of programmed cell death in other organism is_a: GO:0051817 ! modulation of process of other organism involved in symbiotic interaction [Term] id: GO:0052330 name: positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0052518 alt_id: GO:0052529 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "enhancement of other organism programmed cell death by organism" RELATED [] synonym: "positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "upregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "upregulation by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT [] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051712 ! positive regulation of killing of cells of other organism is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction relationship: positively_regulates GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0052433 name: modulation by organism of apoptotic process in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation by organism of apoptosis in other organism involved in symbiotic interaction" NARROW [] synonym: "modulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] is_a: GO:0044532 ! modulation of apoptotic process in other organism is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052547 name: regulation of peptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:ai] synonym: "peptidase regulator activity" RELATED [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008233 ! peptidase activity relationship: regulates GO:0008233 ! peptidase activity [Term] id: GO:0055062 name: phosphate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0055083 ! monovalent inorganic anion homeostasis is_a: GO:0072505 ! divalent inorganic anion homeostasis is_a: GO:0072506 ! trivalent inorganic anion homeostasis [Term] id: GO:0055065 name: metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] subset: goslim_pombe is_a: GO:0055080 ! cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis [Term] id: GO:0055069 name: zinc ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "zinc homeostasis" BROAD [] is_a: GO:0055076 ! transition metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055074 name: calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] synonym: "regulation of calcium ion concentration" EXACT [] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055076 name: transition metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732] is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0055080 name: cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0055081 name: anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of anions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0055082 name: cellular chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0055083 name: monovalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055081 ! anion homeostasis is_a: GO:0098771 ! inorganic ion homeostasis [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process alt_id: GO:0090662 def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] synonym: "membrane transport" EXACT [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process created_by: tanyaberardini creation_date: 2015-10-21T13:22:47Z [Term] id: GO:0055086 name: nucleobase-containing small molecule metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] subset: goslim_drosophila subset: goslim_pombe subset: goslim_yeast synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0055122 name: response to very low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0060049 name: regulation of protein glycosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] synonym: "regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006486 ! protein glycosylation relationship: regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060050 name: positive regulation of protein glycosylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] synonym: "positive regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006486 ! protein glycosylation relationship: positively_regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060051 name: negative regulation of protein glycosylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] synonym: "negative regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006486 ! protein glycosylation relationship: negatively_regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060054 name: positive regulation of epithelial cell proliferation involved in wound healing namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: part_of GO:0042060 ! wound healing relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0060055 name: angiogenesis involved in wound healing namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0001525 ! angiogenesis intersection_of: part_of GO:0042060 ! wound healing relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0060073 name: micturition namespace: biological_process def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph] synonym: "urination" EXACT [] synonym: "urine voiding" EXACT [] xref: Wikipedia:Urination is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion [Term] id: GO:0060089 name: molecular transducer activity namespace: molecular_function def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt] subset: gocheck_do_not_manually_annotate subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0060147 name: regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0060968 ! regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016441 ! posttranscriptional gene silencing relationship: regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060148 name: positive regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060147 ! regulation of posttranscriptional gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016441 ! posttranscriptional gene silencing relationship: positively_regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060149 name: negative regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0060969 ! negative regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016441 ! posttranscriptional gene silencing relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060236 name: regulation of mitotic spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitotic spindle organisation" EXACT [GOC:mah] synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0090224 ! regulation of spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007052 ! mitotic spindle organization relationship: regulates GO:0007052 ! mitotic spindle organization [Term] id: GO:0060245 name: detection of cell density namespace: biological_process def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph] is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043170 ! macromolecule metabolic process relationship: regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0060259 name: regulation of feeding behavior namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb] is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007631 ! feeding behavior relationship: regulates GO:0007631 ! feeding behavior [Term] id: GO:0060271 name: cilium assembly namespace: biological_process alt_id: GO:0042384 def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliogenesis" EXACT [] synonym: "cilium assembly" EXACT [] synonym: "cilium biogenesis" RELATED [GOC:mah] synonym: "cilium formation" EXACT [] synonym: "cilium morphogenesis" RELATED [] synonym: "cilium organization" RELATED [GOC:dph] synonym: "microtubule-based flagellum assembly" EXACT [] xref: Reactome:R-HSA-5617833.2 is_a: GO:0044782 ! cilium organization is_a: GO:0070925 ! organelle assembly is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: has_part GO:0035082 ! axoneme assembly relationship: has_part GO:0035735 ! intraciliary transport involved in cilium assembly relationship: has_part GO:0061512 ! protein localization to cilium relationship: has_part GO:0097712 ! vesicle targeting, trans-Golgi to periciliary membrane compartment relationship: has_part GO:1905349 ! ciliary transition zone assembly property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 [Term] id: GO:0060278 name: regulation of ovulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030728 ! ovulation relationship: regulates GO:0030728 ! ovulation [Term] id: GO:0060279 name: positive regulation of ovulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060278 ! regulation of ovulation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030728 ! ovulation relationship: positively_regulates GO:0030728 ! ovulation [Term] id: GO:0060280 name: negative regulation of ovulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060278 ! regulation of ovulation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030728 ! ovulation relationship: negatively_regulates GO:0030728 ! ovulation [Term] id: GO:0060281 name: regulation of oocyte development namespace: biological_process def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048599 ! oocyte development relationship: regulates GO:0048599 ! oocyte development [Term] id: GO:0060282 name: positive regulation of oocyte development namespace: biological_process def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1905881 ! positive regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048599 ! oocyte development relationship: positively_regulates GO:0048599 ! oocyte development [Term] id: GO:0060283 name: negative regulation of oocyte development namespace: biological_process def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1905880 ! negative regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048599 ! oocyte development relationship: negatively_regulates GO:0048599 ! oocyte development [Term] id: GO:0060284 name: regulation of cell development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048468 ! cell development relationship: regulates GO:0048468 ! cell development [Term] id: GO:0060285 name: cilium-dependent cell motility namespace: biological_process alt_id: GO:0071974 def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. synonym: "ciliary cell motility" RELATED [] synonym: "cilium cell motility" EXACT [] synonym: "microtubule-based flagellar cell motility" EXACT [] is_a: GO:0001539 ! cilium or flagellum-dependent cell motility relationship: has_part GO:0003341 ! cilium movement [Term] id: GO:0060294 name: cilium movement involved in cell motility namespace: biological_process def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement intersection_of: GO:0003341 ! cilium movement intersection_of: part_of GO:0048870 ! cell motility relationship: part_of GO:0060285 ! cilium-dependent cell motility [Term] id: GO:0060295 name: regulation of cilium movement involved in cell motility namespace: biological_process def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:1902019 ! regulation of cilium-dependent cell motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060294 ! cilium movement involved in cell motility relationship: regulates GO:0060294 ! cilium movement involved in cell motility [Term] id: GO:0060322 name: head development namespace: biological_process def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051641 ! cellular localization relationship: regulates GO:0051641 ! cellular localization [Term] id: GO:0060359 name: response to ammonium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound [Term] id: GO:0060467 name: negative regulation of fertilization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009566 ! fertilization relationship: negatively_regulates GO:0009566 ! fertilization [Term] id: GO:0060491 name: regulation of cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030031 ! cell projection assembly relationship: regulates GO:0030031 ! cell projection assembly [Term] id: GO:0060548 name: negative regulation of cell death namespace: biological_process def: "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008219 ! cell death relationship: negatively_regulates GO:0008219 ! cell death created_by: dph creation_date: 2009-04-13T01:56:10Z [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0060561 name: apoptotic process involved in morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in development" RELATED [] synonym: "apoptosis involved in morphogenesis" NARROW [] synonym: "morphogenetic apoptosis" RELATED [GOC:dph] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T09:17:27Z [Term] id: GO:0060623 name: regulation of chromosome condensation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030261 ! chromosome condensation relationship: regulates GO:0030261 ! chromosome condensation created_by: dph creation_date: 2009-05-18T02:12:13Z [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016192 ! vesicle-mediated transport relationship: regulates GO:0016192 ! vesicle-mediated transport created_by: dph creation_date: 2009-05-18T02:29:43Z [Term] id: GO:0060632 name: regulation of microtubule-based movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007018 ! microtubule-based movement relationship: regulates GO:0007018 ! microtubule-based movement created_by: dph creation_date: 2009-05-18T03:07:02Z [Term] id: GO:0060759 name: regulation of response to cytokine stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034097 ! response to cytokine relationship: regulates GO:0034097 ! response to cytokine created_by: dph creation_date: 2009-06-22T02:56:12Z [Term] id: GO:0060760 name: positive regulation of response to cytokine stimulus namespace: biological_process def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034097 ! response to cytokine relationship: positively_regulates GO:0034097 ! response to cytokine created_by: dph creation_date: 2009-06-22T02:58:04Z [Term] id: GO:0060761 name: negative regulation of response to cytokine stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034097 ! response to cytokine relationship: negatively_regulates GO:0034097 ! response to cytokine created_by: dph creation_date: 2009-06-22T02:59:57Z [Term] id: GO:0060966 name: regulation of gene silencing by RNA namespace: biological_process def: "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] is_a: GO:0060968 ! regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031047 ! gene silencing by RNA relationship: regulates GO:0031047 ! gene silencing by RNA created_by: dph creation_date: 2009-10-05T03:17:02Z [Term] id: GO:0060967 name: negative regulation of gene silencing by RNA namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] is_a: GO:0060966 ! regulation of gene silencing by RNA is_a: GO:0060969 ! negative regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031047 ! gene silencing by RNA relationship: negatively_regulates GO:0031047 ! gene silencing by RNA created_by: dph creation_date: 2009-10-05T03:21:05Z [Term] id: GO:0060968 name: regulation of gene silencing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016458 ! gene silencing relationship: regulates GO:0016458 ! gene silencing created_by: dph creation_date: 2009-10-05T03:23:56Z [Term] id: GO:0060969 name: negative regulation of gene silencing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0060968 ! regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016458 ! gene silencing relationship: negatively_regulates GO:0016458 ! gene silencing created_by: dph creation_date: 2009-10-05T03:26:19Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: janelomax creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061041 name: regulation of wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph] is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042060 ! wound healing relationship: regulates GO:0042060 ! wound healing created_by: dph creation_date: 2010-02-25T10:14:37Z [Term] id: GO:0061042 name: vascular wound healing namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] is_a: GO:0060055 ! angiogenesis involved in wound healing created_by: dph creation_date: 2010-02-25T10:18:26Z [Term] id: GO:0061043 name: regulation of vascular wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:dph] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0061041 ! regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061042 ! vascular wound healing relationship: regulates GO:0061042 ! vascular wound healing created_by: dph creation_date: 2010-02-25T10:21:59Z [Term] id: GO:0061044 name: negative regulation of vascular wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:0061043 ! regulation of vascular wound healing is_a: GO:0061045 ! negative regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061042 ! vascular wound healing relationship: negatively_regulates GO:0061042 ! vascular wound healing created_by: dph creation_date: 2010-02-25T10:24:28Z [Term] id: GO:0061045 name: negative regulation of wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042060 ! wound healing relationship: negatively_regulates GO:0042060 ! wound healing created_by: dph creation_date: 2010-02-25T10:33:30Z [Term] id: GO:0061476 name: response to anticoagulant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus." [GOC:dph] is_a: GO:0042493 ! response to drug created_by: dph creation_date: 2012-11-07T09:07:00Z [Term] id: GO:0061477 name: response to aromatase inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus." [GOC:dph] is_a: GO:0042221 ! response to chemical created_by: dph creation_date: 2012-11-07T09:08:36Z [Term] id: GO:0061478 name: response to platelet aggregation inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus." [GOC:dph] is_a: GO:0042493 ! response to drug created_by: dph creation_date: 2012-11-07T09:09:37Z [Term] id: GO:0061479 name: response to reverse transcriptase inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus." [GOC:dph] is_a: GO:0046677 ! response to antibiotic created_by: dph creation_date: 2012-11-07T09:10:51Z [Term] id: GO:0061512 name: protein localization to cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph] is_a: GO:0033365 ! protein localization to organelle property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 property_value: RO:0002161 NCBITaxon:3398 property_value: RO:0002161 NCBITaxon:4890 property_value: RO:0002161 NCBITaxon:5782 created_by: dph creation_date: 2013-03-22T15:41:44Z [Term] id: GO:0061629 name: RNA polymerase II-specific DNA-binding transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] synonym: "RNA polymerase II sequence-specific DNA binding transcription factor binding" EXACT [] synonym: "RNA polymerase II sequence-specific DNA-binding transcription factor binding" EXACT [] is_a: GO:0140297 ! DNA-binding transcription factor binding created_by: dph creation_date: 2014-05-15T09:12:24Z [Term] id: GO:0061650 name: ubiquitin-like protein conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [] synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:15:27Z [Term] id: GO:0061651 name: Atg12 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:17:36Z [Term] id: GO:0061659 name: ubiquitin-like protein ligase activity namespace: molecular_function def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] synonym: "small conjugating protein ligase activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:46:23Z [Term] id: GO:0061660 name: Atg12 ligase activity namespace: molecular_function def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T13:50:42Z [Term] id: GO:0061736 name: engulfment of target by autophagosome namespace: biological_process def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL] is_a: GO:0010324 ! membrane invagination intersection_of: GO:0010324 ! membrane invagination intersection_of: part_of GO:0000045 ! autophagosome assembly relationship: part_of GO:0000045 ! autophagosome assembly created_by: dph creation_date: 2015-09-14T14:10:24Z [Term] id: GO:0061743 name: motor learning namespace: biological_process def: "Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience." [GOC:bf, GOC:PARL, Wikipedia:Motor_learning] is_a: GO:0007612 ! learning created_by: dph creation_date: 2015-11-09T12:40:29Z [Term] id: GO:0061804 name: mitotic spindle formation (spindle phase one) namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase." [GOC:dph, GOC:vw, PMID:21920317] synonym: "mitotic spindle elongation during mitotic prophase" EXACT [] synonym: "mitotic spindle elongation during prophase" EXACT [] synonym: "mitotic spindle elongation during prophase and prometaphase" EXACT [] is_a: GO:0007052 ! mitotic spindle organization intersection_of: GO:0007051 ! spindle organization intersection_of: happens_during GO:0000088 ! mitotic prophase intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000088 ! mitotic prophase relationship: part_of GO:0000022 ! mitotic spindle elongation relationship: part_of GO:0090307 ! mitotic spindle assembly created_by: dph creation_date: 2016-11-06T23:08:01Z [Term] id: GO:0061919 name: process utilizing autophagic mechanism namespace: biological_process def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process created_by: dph creation_date: 2017-07-13T19:42:14Z [Term] id: GO:0061983 name: meiosis II cell cycle process namespace: biological_process def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397] synonym: "second meiotic division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process created_by: dph creation_date: 2018-02-14T22:37:44Z [Term] id: GO:0062012 name: regulation of small molecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] synonym: "regulation of small molecule metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044281 ! small molecule metabolic process relationship: regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:11:54Z [Term] id: GO:0062013 name: positive regulation of small molecule metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "positive regulation of small molecule metabolism" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044281 ! small molecule metabolic process relationship: positively_regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:25:10Z [Term] id: GO:0062014 name: negative regulation of small molecule metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "negative regulation of small molecule metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044281 ! small molecule metabolic process relationship: negatively_regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:27:23Z [Term] id: GO:0062033 name: positive regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0045840 ! positive regulation of mitotic nuclear division is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000070 ! mitotic sister chromatid segregation relationship: positively_regulates GO:0000070 ! mitotic sister chromatid segregation created_by: dph creation_date: 2018-04-23T14:32:23Z [Term] id: GO:0062125 name: regulation of mitochondrial gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA)." [PMID:28285835] is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140053 ! mitochondrial gene expression relationship: regulates GO:0140053 ! mitochondrial gene expression created_by: dph creation_date: 2019-05-30T16:45:04Z [Term] id: GO:0062149 name: detection of stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031] is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain relationship: part_of GO:0019233 ! sensory perception of pain created_by: dph creation_date: 2019-09-13T13:48:47Z [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: goslim_pir synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003674 ! molecular_function relationship: regulates GO:0003674 ! molecular_function [Term] id: GO:0065010 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle [Term] id: GO:0070011 name: peptidase activity, acting on L-amino acid peptides namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah] xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] subset: goslim_mouse is_a: GO:0043233 ! organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043229 ! intracellular organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0070062 name: extracellular exosome namespace: cellular_component def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] synonym: "exosome" EXACT [GOC:pr] synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles] is_a: GO:1903561 ! extracellular vesicle relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0070085 name: glycosylation namespace: biological_process def: "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah] xref: Wikipedia:Glycosylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0070141 name: response to UV-A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:BHF, GOC:mah] synonym: "response to UV-A light stimulus" EXACT [] synonym: "response to UV-A radiation stimulus" EXACT [] synonym: "response to UVA light stimulus" EXACT [] synonym: "response to UVA radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0070192 name: chromosome organization involved in meiotic cell cycle namespace: biological_process def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051276 ! chromosome organization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045184 ! establishment of protein localization relationship: regulates GO:0045184 ! establishment of protein localization [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000226 ! microtubule cytoskeleton organization relationship: regulates GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0070527 name: platelet aggregation namespace: biological_process def: "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] synonym: "blood platelet aggregation" EXACT [CL:0000233] synonym: "thrombocyte aggregation" RELATED [CL:0000233] is_a: GO:0034109 ! homotypic cell-cell adhesion relationship: part_of GO:0030168 ! platelet activation [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization created_by: midori creation_date: 2009-06-16T04:08:29Z [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus created_by: midori creation_date: 2009-08-27T04:41:45Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly created_by: midori creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0071103 name: DNA conformation change namespace: biological_process def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah] subset: goslim_metagenomics synonym: "DNA conformation modification" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization created_by: midori creation_date: 2009-11-09T11:36:34Z [Term] id: GO:0071214 name: cellular response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "cellular response to abiotic stress" NARROW [GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0104004 ! cellular response to environmental stimulus created_by: midori creation_date: 2009-12-03T01:02:11Z [Term] id: GO:0071310 name: cellular response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-10T04:46:04Z [Term] id: GO:0071383 name: cellular response to steroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0048545 ! response to steroid hormone is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-11T03:49:02Z [Term] id: GO:0071396 name: cellular response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] is_a: GO:0033993 ! response to lipid is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-11T04:37:10Z [Term] id: GO:0071407 name: cellular response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah] synonym: "cellular response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-14T02:55:58Z [Term] id: GO:0071467 name: cellular response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:mah, Wikipedia:PH] is_a: GO:0009268 ! response to pH is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-18T11:41:54Z [Term] id: GO:0071478 name: cellular response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to radiation stimulus" EXACT [GOC:mah] is_a: GO:0009314 ! response to radiation is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-18T01:59:37Z [Term] id: GO:0071479 name: cellular response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] synonym: "cellular response to ionising radiation" EXACT [GOC:mah] synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah] is_a: GO:0010212 ! response to ionizing radiation is_a: GO:0071478 ! cellular response to radiation created_by: midori creation_date: 2009-12-18T02:00:31Z [Term] id: GO:0071480 name: cellular response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] synonym: "cellular response to gamma ray" RELATED [GOC:mah] synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah] is_a: GO:0010332 ! response to gamma radiation is_a: GO:0071479 ! cellular response to ionizing radiation created_by: midori creation_date: 2009-12-18T02:00:50Z [Term] id: GO:0071481 name: cellular response to X-ray namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] synonym: "cellular response to X-ray radiation stimulus" EXACT [GOC:mah] is_a: GO:0010165 ! response to X-ray is_a: GO:0071479 ! cellular response to ionizing radiation created_by: midori creation_date: 2009-12-18T02:00:59Z [Term] id: GO:0071482 name: cellular response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] is_a: GO:0009416 ! response to light stimulus is_a: GO:0071478 ! cellular response to radiation created_by: midori creation_date: 2009-12-18T02:03:49Z [Term] id: GO:0071483 name: cellular response to blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:mah] synonym: "cellular response to blue light stimulus" EXACT [GOC:mah] is_a: GO:0009637 ! response to blue light is_a: GO:0071482 ! cellular response to light stimulus created_by: midori creation_date: 2009-12-18T02:09:48Z [Term] id: GO:0071484 name: cellular response to light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:mah] is_a: GO:0009642 ! response to light intensity is_a: GO:0071482 ! cellular response to light stimulus created_by: midori creation_date: 2009-12-18T02:11:03Z [Term] id: GO:0071485 name: cellular response to absence of light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:mah] synonym: "cellular response to darkness" RELATED [] is_a: GO:0009646 ! response to absence of light is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:12Z [Term] id: GO:0071486 name: cellular response to high light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:mah] is_a: GO:0009644 ! response to high light intensity is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:23Z [Term] id: GO:0071487 name: cellular response to low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:mah] is_a: GO:0009645 ! response to low light intensity stimulus is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:29Z [Term] id: GO:0071488 name: cellular response to very low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mah] is_a: GO:0055122 ! response to very low light intensity stimulus is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:40Z [Term] id: GO:0071489 name: cellular response to red or far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] is_a: GO:0009639 ! response to red or far red light is_a: GO:0071482 ! cellular response to light stimulus created_by: midori creation_date: 2009-12-18T02:18:25Z [Term] id: GO:0071490 name: cellular response to far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] synonym: "cellular response to far red light stimulus" EXACT [GOC:mah] is_a: GO:0010218 ! response to far red light is_a: GO:0071489 ! cellular response to red or far red light created_by: midori creation_date: 2009-12-18T02:19:40Z [Term] id: GO:0071491 name: cellular response to red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] synonym: "cellular response to red light stimulus" EXACT [GOC:mah] is_a: GO:0010114 ! response to red light is_a: GO:0071489 ! cellular response to red or far red light created_by: midori creation_date: 2009-12-18T02:19:47Z [Term] id: GO:0071492 name: cellular response to UV-A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:mah] synonym: "cellular response to UV-A light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-A radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVA light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVA radiation stimulus" EXACT [GOC:mah] is_a: GO:0034644 ! cellular response to UV is_a: GO:0070141 ! response to UV-A created_by: midori creation_date: 2009-12-18T02:21:51Z [Term] id: GO:0071493 name: cellular response to UV-B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:mah] synonym: "cellular response to medium wave ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to medium wave ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-B light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-B radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVB light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVB radiation stimulus" EXACT [GOC:mah] is_a: GO:0010224 ! response to UV-B is_a: GO:0034644 ! cellular response to UV created_by: midori creation_date: 2009-12-18T02:21:56Z [Term] id: GO:0071494 name: cellular response to UV-C namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:mah] synonym: "cellular response to germicidal ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to germicidal ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to shortwave ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to shortwave ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-C light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-C radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVC light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVC radiation stimulus" EXACT [GOC:mah] is_a: GO:0010225 ! response to UV-C is_a: GO:0034644 ! cellular response to UV created_by: midori creation_date: 2009-12-18T02:22:01Z [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009719 ! response to endogenous stimulus created_by: midori creation_date: 2009-12-18T02:25:40Z [Term] id: GO:0071496 name: cellular response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009605 ! response to external stimulus created_by: midori creation_date: 2009-12-18T02:36:52Z [Term] id: GO:0071692 name: protein localization to extracellular region namespace: biological_process def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] synonym: "protein localisation in extracellular region" EXACT [GOC:mah] synonym: "protein localization in extracellular region" EXACT [] is_a: GO:0008104 ! protein localization created_by: midori creation_date: 2010-02-25T04:00:13Z [Term] id: GO:0071695 name: anatomical structure maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0048856 ! anatomical structure development created_by: midori creation_date: 2010-03-02T11:43:38Z [Term] id: GO:0071702 name: organic substance transport namespace: biological_process def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah] is_a: GO:0006810 ! transport created_by: midori creation_date: 2010-03-08T02:15:14Z [Term] id: GO:0071704 name: organic substance metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah] synonym: "organic molecular entity metabolic process" EXACT [] synonym: "organic molecular entity metabolism" EXACT [] synonym: "organic substance metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: midori creation_date: 2010-03-08T03:32:18Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006810 ! transport created_by: midori creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0009987 ! cellular process created_by: midori creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071867 name: response to monoamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] synonym: "response to monoamine stimulus" EXACT [GOC:dos] is_a: GO:0010243 ! response to organonitrogen compound created_by: midori creation_date: 2010-09-13T02:36:37Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures." [GOC:mah] subset: goslim_flybase_ribbon is_a: GO:0110165 ! cellular anatomical entity created_by: midori creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0071971 name: extracellular exosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458] synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0097734 ! extracellular exosome biogenesis created_by: midori creation_date: 2010-10-18T03:44:18Z [Term] id: GO:0072337 name: modified amino acid transport namespace: biological_process def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "amino acid derivative transport" EXACT [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport created_by: midori creation_date: 2010-11-04T12:18:23Z [Term] id: GO:0072347 name: response to anesthetic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [GOC:sart] synonym: "response to anaesthetic" EXACT [GOC:mah] is_a: GO:0042493 ! response to drug created_by: midori creation_date: 2010-11-10T01:26:18Z [Term] id: GO:0072349 name: modified amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah] synonym: "amino acid derivative transmembrane transporter activity" EXACT [] synonym: "modified amino acid transporter activity" BROAD [GOC:mah] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0072337 ! modified amino acid transport created_by: midori creation_date: 2010-11-11T11:50:31Z [Term] id: GO:0072358 name: cardiovascular system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels." [GOC:mah, UBERON:0004535] is_a: GO:0048731 ! system development relationship: part_of GO:0072359 ! circulatory system development created_by: midori creation_date: 2010-11-16T11:25:49Z [Term] id: GO:0072359 name: circulatory system development namespace: biological_process def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] is_a: GO:0048731 ! system development created_by: midori creation_date: 2010-11-16T11:27:39Z [Term] id: GO:0072375 name: medium-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375] synonym: "middle-term memory" EXACT [GOC:sart] synonym: "MTM" NARROW [GOC:sart] is_a: GO:0007613 ! memory created_by: midori creation_date: 2010-11-22T11:26:54Z [Term] id: GO:0072503 name: cellular divalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular trivalent inorganic cation homeostasis' ; GO:0072504'). is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis created_by: midori creation_date: 2010-12-16T01:25:40Z [Term] id: GO:0072505 name: divalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'trivalent inorganic anion homeostasis' ; GO:0072506'). is_a: GO:0055081 ! anion homeostasis is_a: GO:0098771 ! inorganic ion homeostasis created_by: midori creation_date: 2010-12-16T01:39:00Z [Term] id: GO:0072506 name: trivalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'divalent inorganic anion homeostasis' ; GO:0072505'). is_a: GO:0055081 ! anion homeostasis is_a: GO:0098771 ! inorganic ion homeostasis created_by: midori creation_date: 2010-12-16T01:39:39Z [Term] id: GO:0072507 name: divalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508'). is_a: GO:0055080 ! cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis created_by: midori creation_date: 2010-12-16T03:22:48Z [Term] id: GO:0072521 name: purine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] synonym: "purine and derivative metabolic process" EXACT [] synonym: "purine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: midori creation_date: 2011-01-04T03:03:59Z [Term] id: GO:0072522 name: purine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] synonym: "purine and derivative biosynthetic process" EXACT [] synonym: "purine-containing compound anabolism" EXACT [GOC:mah] synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "purine-containing compound formation" EXACT [GOC:mah] synonym: "purine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072521 ! purine-containing compound metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: midori creation_date: 2011-01-04T03:15:29Z [Term] id: GO:0072527 name: pyrimidine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah] synonym: "pyrimidine and derivative metabolic process" EXACT [] synonym: "pyrimidine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: midori creation_date: 2011-01-04T03:27:19Z [Term] id: GO:0072718 name: response to cisplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah] is_a: GO:0009636 ! response to toxic substance is_a: GO:0097327 ! response to antineoplastic agent created_by: midori creation_date: 2012-04-30T11:31:05Z [Term] id: GO:0072758 name: response to topoisomerase inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah] is_a: GO:0042221 ! response to chemical created_by: midori creation_date: 2012-11-09T11:34:51Z [Term] id: GO:0075044 name: positive regulation by symbiont of host autophagy namespace: biological_process def: "Any process in which a symbiont organism increases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "autophagy of host cells during interaction with symbiont" RELATED [GOC:dph] synonym: "autophagy of host cells involved in interaction with symbiont" RELATED [] synonym: "positive regulation by symbiont of host autophagotic process" RELATED [] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0075071 ! modulation by symbiont of host autophagy intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0075071 name: modulation by symbiont of host autophagy namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "autophagy during symbiotic interaction" RELATED [GOC:dph] synonym: "autophagy involved in symbiotic interaction" RELATED [] synonym: "modulation by symbiont of host autophagic process" RELATED [] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0006914 ! autophagy [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044238 ! primary metabolic process relationship: regulates GO:0044238 ! primary metabolic process created_by: donghui creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0080134 name: regulation of response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006950 ! response to stress relationship: regulates GO:0006950 ! response to stress created_by: donghui creation_date: 2009-05-06T04:51:28Z [Term] id: GO:0080135 name: regulation of cellular response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033554 ! cellular response to stress relationship: regulates GO:0033554 ! cellular response to stress created_by: donghui creation_date: 2009-05-06T05:02:52Z [Term] id: GO:0080154 name: regulation of fertilization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009566 ! fertilization relationship: regulates GO:0009566 ! fertilization created_by: donghui creation_date: 2010-09-01T03:44:27Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022402 ! cell cycle process relationship: positively_regulates GO:0022402 ! cell cycle process created_by: tanyaberardini creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015833 ! peptide transport relationship: regulates GO:0015833 ! peptide transport created_by: tanyaberardini creation_date: 2009-10-23T11:21:38Z [Term] id: GO:0090139 name: mitochondrial DNA packaging namespace: biological_process def: "Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0036385 ! nucleoid DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion created_by: tanyaberardini creation_date: 2009-12-08T02:12:19Z [Term] id: GO:0090169 name: regulation of spindle assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090224 ! regulation of spindle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051225 ! spindle assembly relationship: regulates GO:0051225 ! spindle assembly created_by: tanyaberardini creation_date: 2009-12-11T10:17:51Z [Term] id: GO:0090224 name: regulation of spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of spindle organisation" EXACT [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007051 ! spindle organization relationship: regulates GO:0007051 ! spindle organization created_by: tanyaberardini creation_date: 2010-01-13T11:04:53Z [Term] id: GO:0090227 name: regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:2000030 ! regulation of response to red or far red light intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010017 ! red or far-red light signaling pathway relationship: regulates GO:0010017 ! red or far-red light signaling pathway created_by: tanyaberardini creation_date: 2010-01-19T04:03:29Z [Term] id: GO:0090228 name: positive regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "positive regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "positive regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0090227 ! regulation of red or far-red light signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010017 ! red or far-red light signaling pathway relationship: positively_regulates GO:0010017 ! red or far-red light signaling pathway created_by: tanyaberardini creation_date: 2010-01-19T04:03:29Z [Term] id: GO:0090229 name: negative regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "negative regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "negative regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0090227 ! regulation of red or far-red light signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010017 ! red or far-red light signaling pathway relationship: negatively_regulates GO:0010017 ! red or far-red light signaling pathway created_by: tanyaberardini creation_date: 2010-01-19T04:03:29Z [Term] id: GO:0090283 name: regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033578 ! protein glycosylation in Golgi relationship: regulates GO:0033578 ! protein glycosylation in Golgi created_by: tanyaberardini creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090284 name: positive regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060050 ! positive regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033578 ! protein glycosylation in Golgi relationship: positively_regulates GO:0033578 ! protein glycosylation in Golgi created_by: tanyaberardini creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090285 name: negative regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060051 ! negative regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033578 ! protein glycosylation in Golgi relationship: negatively_regulates GO:0033578 ! protein glycosylation in Golgi created_by: tanyaberardini creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090303 name: positive regulation of wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042060 ! wound healing relationship: positively_regulates GO:0042060 ! wound healing created_by: tanyaberardini creation_date: 2010-03-22T02:12:03Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process created_by: tanyaberardini creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090306 name: spindle assembly involved in meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw] synonym: "meiotic spindle assembly" EXACT [GOC:vw] is_a: GO:0000212 ! meiotic spindle organization is_a: GO:0051225 ! spindle assembly intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0140013 ! meiotic nuclear division relationship: part_of GO:0140013 ! meiotic nuclear division created_by: tanyaberardini creation_date: 2010-04-09T11:21:56Z [Term] id: GO:0090307 name: mitotic spindle assembly namespace: biological_process def: "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw] synonym: "spindle assembly involved in mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051225 ! spindle assembly intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division created_by: tanyaberardini creation_date: 2010-04-09T11:31:28Z [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006886 ! intracellular protein transport relationship: positively_regulates GO:0006886 ! intracellular protein transport created_by: tanyaberardini creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006886 ! intracellular protein transport relationship: negatively_regulates GO:0006886 ! intracellular protein transport created_by: tanyaberardini creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090325 name: regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tanyaberardini creation_date: 2010-05-14T10:24:29Z [Term] id: GO:0090326 name: positive regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0050789 ! regulation of biological process intersection_of: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tanyaberardini creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090327 name: negative regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tanyaberardini creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090328 name: regulation of olfactory learning namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008355 ! olfactory learning relationship: regulates GO:0008355 ! olfactory learning created_by: tanyaberardini creation_date: 2010-05-14T10:37:22Z [Term] id: GO:0090330 name: regulation of platelet aggregation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070527 ! platelet aggregation relationship: regulates GO:0070527 ! platelet aggregation created_by: tanyaberardini creation_date: 2010-05-14T10:46:08Z [Term] id: GO:0090331 name: negative regulation of platelet aggregation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF] synonym: "platelet disaggregation" NARROW [GOC:dph, PMID:12871378] is_a: GO:0010544 ! negative regulation of platelet activation is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:0090330 ! regulation of platelet aggregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070527 ! platelet aggregation relationship: negatively_regulates GO:0070527 ! platelet aggregation created_by: tanyaberardini creation_date: 2010-05-14T10:46:08Z [Term] id: GO:0090407 name: organophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: tanyaberardini creation_date: 2011-02-26T02:22:41Z [Term] id: GO:0090482 name: vitamin transmembrane transporter activity namespace: molecular_function alt_id: GO:0051183 def: "Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb] synonym: "vitamin or cofactor transporter activity" BROAD [] synonym: "vitamin transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0035461 ! vitamin transmembrane transport created_by: tanyaberardini creation_date: 2012-10-02T16:50:50Z [Term] id: GO:0090594 name: inflammatory response to wounding namespace: biological_process def: "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." [GOC:add] is_a: GO:0006954 ! inflammatory response is_a: GO:0009611 ! response to wounding created_by: tanyaberardini creation_date: 2014-08-12T12:13:53Z [Term] id: GO:0090605 name: submerged biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] synonym: "solid substrate biofilm formation" RELATED [] is_a: GO:0042710 ! biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:44:46Z [Term] id: GO:0090609 name: single-species submerged biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] is_a: GO:0044010 ! single-species biofilm formation is_a: GO:0090605 ! submerged biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:55:15Z [Term] id: GO:0097014 name: ciliary plasm namespace: cellular_component def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". synonym: "cilial cytoplasm" RELATED [] synonym: "ciliary cytoplasm" RELATED [] synonym: "cilium cytoplasm" RELATED [] synonym: "cilium plasm" EXACT [] synonym: "microtubule-based flagellar cytoplasm" RELATED [] synonym: "microtubule-based flagellar matrix" NARROW [] synonym: "microtubule-based flagellum cytoplasm" RELATED [] synonym: "microtubule-based flagellum matrix" NARROW [] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005929 ! cilium relationship: part_of GO:0005929 ! cilium created_by: paola creation_date: 2011-03-23T01:52:31Z [Term] id: GO:0097060 name: synaptic membrane namespace: cellular_component def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104] subset: goslim_synapse is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0098590 ! plasma membrane region intersection_of: part_of GO:0045202 ! synapse relationship: part_of GO:0045202 ! synapse created_by: paola creation_date: 2011-06-07T11:22:09Z [Term] id: GO:0097159 name: organic cyclic compound binding namespace: molecular_function def: "Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672] is_a: GO:0005488 ! binding created_by: paola creation_date: 2011-09-23T02:31:01Z [Term] id: GO:0097190 name: apoptotic signaling pathway namespace: biological_process alt_id: GO:0008624 def: "A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. synonym: "apoptotic signalling pathway" EXACT [GOC:mah] synonym: "induction of apoptosis by extracellular signals" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0006915 ! apoptotic process created_by: paola creation_date: 2011-11-23T09:30:23Z [Term] id: GO:0097194 name: execution phase of apoptosis namespace: biological_process def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] synonym: "apoptosis" NARROW [] synonym: "execution phase of apoptotic process" EXACT [] is_a: GO:0009987 ! cellular process relationship: has_part GO:0032060 ! bleb assembly relationship: part_of GO:0006915 ! apoptotic process created_by: paola creation_date: 2011-11-23T09:45:24Z [Term] id: GO:0097270 name: dishabituation namespace: biological_process def: "The temporary recovery of response to a stimulus when a novel stimulus is added." [GOC:kmv, PMID:11390637, Wikipedia:Habituation] is_a: GO:0046958 ! nonassociative learning created_by: paola creation_date: 2012-03-20T01:39:25Z [Term] id: GO:0097305 name: response to alcohol namespace: biological_process alt_id: GO:1990335 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr, PMID:24014527] synonym: "process resulting in tolerance to alcohol" NARROW [] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: paola creation_date: 2012-05-15T03:48:45Z [Term] id: GO:0097327 name: response to antineoplastic agent namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms." [GOC:pr] is_a: GO:0042493 ! response to drug created_by: paola creation_date: 2012-06-12T10:48:28Z [Term] id: GO:0097328 name: response to carboplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus." [GOC:pr] is_a: GO:0097327 ! response to antineoplastic agent created_by: paola creation_date: 2012-06-12T10:50:34Z [Term] id: GO:0097329 name: response to antimetabolite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [GOC:pr] is_a: GO:0042221 ! response to chemical created_by: paola creation_date: 2012-06-12T10:52:01Z [Term] id: GO:0097330 name: response to 5-fluoro-2'-deoxyuridine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: paola creation_date: 2012-06-12T10:53:35Z [Term] id: GO:0097331 name: response to cytarabine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1903416 ! response to glycoside created_by: paola creation_date: 2012-06-12T10:55:29Z [Term] id: GO:0097332 name: response to antipsychotic drug namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect." [GOC:pr] is_a: GO:0042493 ! response to drug created_by: paola creation_date: 2012-06-12T10:58:13Z [Term] id: GO:0097333 name: response to olanzapine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:00:04Z [Term] id: GO:0097334 name: response to perphenazine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:01:14Z [Term] id: GO:0097335 name: response to quetiapine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:03:22Z [Term] id: GO:0097336 name: response to risperidone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: paola creation_date: 2012-06-12T11:04:31Z [Term] id: GO:0097337 name: response to ziprasidone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:05:31Z [Term] id: GO:0097338 name: response to clozapine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus." [GOC:pr] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:07:01Z [Term] id: GO:0097366 name: response to bronchodilator namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to bronchodilator agent" EXACT [] synonym: "response to broncholytic agent" RELATED [] is_a: GO:0042493 ! response to drug created_by: paola creation_date: 2012-08-01T16:13:31Z [Term] id: GO:0097425 name: obsolete smooth endoplasmic reticulum part namespace: cellular_component def: "OBSOLETE. Any constituent part of the smooth endoplasmic reticulum (also called smooth ER, or SER)." [NIF_Subcellular:sao184202831] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "SER subcomponent" RELATED [NIF_Subcellular:sao1842028314] xref: NIF_Subcellular:sao184202831 is_obsolete: true consider: GO:0005790 created_by: paola creation_date: 2012-11-07T13:45:14Z [Term] id: GO:0097458 name: obsolete neuron part namespace: cellular_component def: "OBSOLETE. Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [GOC:pr, Wikipedia:Neuron] subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon is_obsolete: true consider: CL:0000540 created_by: paola creation_date: 2012-12-19T16:53:50Z [Term] id: GO:0097659 name: nucleic acid-templated transcription namespace: biological_process def: "The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA)." [GOC:pr, GOC:txnOH, GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_mouse is_a: GO:0032774 ! RNA biosynthetic process created_by: paola creation_date: 2014-10-01T13:49:27Z [Term] id: GO:0097708 name: intracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005622 ! intracellular created_by: paola creation_date: 2016-03-29T17:39:45Z [Term] id: GO:0097711 name: ciliary basal body-plasma membrane docking namespace: biological_process def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235, Reactome:R-HSA-5620912.1] comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. synonym: "anchoring of the basal body to the plasma membrane" RELATED [] synonym: "ciliary basal body docking" EXACT [] xref: Reactome:R-HSA-5620912.1 is_a: GO:0140056 ! organelle localization by membrane tethering relationship: part_of GO:0060271 ! cilium assembly created_by: paola creation_date: 2016-08-05T16:12:33Z [Term] id: GO:0097712 name: vesicle targeting, trans-Golgi to periciliary membrane compartment namespace: biological_process def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645, Reactome:R-HSA-5620920.1] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0060271 ! cilium assembly created_by: paola creation_date: 2016-08-05T16:16:28Z [Term] id: GO:0097722 name: sperm motility namespace: biological_process def: "Any process involved in the controlled movement of a sperm cell." [GOC:cilia, GOC:krc] subset: gocheck_do_not_annotate synonym: "sperm movement" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0048870 ! cell motility created_by: paola creation_date: 2016-09-01T12:00:45Z [Term] id: GO:0097734 name: extracellular exosome biogenesis namespace: biological_process def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495] synonym: "exosome assembly or secretion" EXACT [] synonym: "exosome biogenesis" EXACT [] synonym: "exosome production" EXACT [] synonym: "ILV assembly" RELATED [] synonym: "intraluminal vesicle assembly" RELATED [] is_a: GO:0140112 ! extracellular vesicle biogenesis created_by: paola creation_date: 2016-10-03T14:35:25Z [Term] id: GO:0098588 name: bounding membrane of organelle namespace: cellular_component def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. is_a: GO:0031090 ! organelle membrane created_by: davidos creation_date: 2014-02-26T13:41:31Z [Term] id: GO:0098589 name: membrane region namespace: cellular_component def: "A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_manually_annotate synonym: "region of membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0098805 ! whole membrane disjoint_from: GO:0098805 ! whole membrane relationship: part_of GO:0098805 ! whole membrane creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0098590 name: plasma membrane region namespace: cellular_component def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_manually_annotate synonym: "region of plasma membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane created_by: davidos creation_date: 2014-03-06T11:55:32Z [Term] id: GO:0098609 name: cell-cell adhesion namespace: biological_process alt_id: GO:0016337 def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] synonym: "single organismal cell-cell adhesion" RELATED [] is_a: GO:0007155 ! cell adhesion created_by: davidos creation_date: 2014-04-16T13:40:03Z [Term] id: GO:0098630 name: aggregation of unicellular organisms namespace: biological_process def: "The clustering together of unicellular organisms in suspension form aggregates." [GOC:dos] synonym: "aggregation of single cell organisms" EXACT [] is_a: GO:0098743 ! cell aggregation [Term] id: GO:0098631 name: cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell." [Wikipedia:Cell_adhesion] synonym: "cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell adhesion" EXACT [] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: part_of GO:0007155 ! cell adhesion relationship: part_of GO:0007155 ! cell adhesion [Term] id: GO:0098632 name: cell-cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] synonym: "cell-cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell-cell adhesion" EXACT [] is_a: GO:0005515 ! protein binding is_a: GO:0098631 ! cell adhesion mediator activity intersection_of: GO:0005515 ! protein binding intersection_of: part_of GO:0098609 ! cell-cell adhesion relationship: part_of GO:0098609 ! cell-cell adhesion [Term] id: GO:0098656 name: anion transmembrane transport namespace: biological_process alt_id: GO:0099133 def: "The process in which an anion is transported across a membrane." [GOC:dos, GOC:vw] synonym: "ATP hydrolysis coupled anion transmembrane transport" NARROW [] is_a: GO:0006820 ! anion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0098743 name: cell aggregation namespace: biological_process def: "The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation." [GOC:dos] is_a: GO:0009987 ! cellular process [Term] id: GO:0098762 name: meiotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: happens_during GO:0051321 ! meiotic cell cycle relationship: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0098763 name: mitotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: happens_during GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000278 ! mitotic cell cycle [Term] id: GO:0098764 name: meiosis I cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase [Term] id: GO:0098765 name: meiosis II cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division)." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase [Term] id: GO:0098771 name: inorganic ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos] is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0098772 name: molecular function regulator namespace: molecular_function def: "A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators." [GOC:dos, GOC:pt] subset: goslim_flybase_ribbon is_a: GO:0003674 ! molecular_function relationship: part_of GO:0065009 ! regulation of molecular function [Term] id: GO:0098791 name: Golgi subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi Apparatus." [GOC:dos] is_a: GO:0031984 ! organelle subcompartment intersection_of: GO:0031984 ! organelle subcompartment intersection_of: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0098794 name: postsynapse namespace: cellular_component def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] subset: goslim_synapse is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0045202 ! synapse [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane [Term] id: GO:0098797 name: plasma membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0098798 name: mitochondrial protein complex namespace: cellular_component def: "A protein complex that is part of a mitochondrion." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0098801 name: regulation of renal system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003014 ! renal system process relationship: regulates GO:0003014 ! renal system process [Term] id: GO:0098805 name: whole membrane namespace: cellular_component def: "Any lipid bilayer that completely encloses some structure, and all the proteins embedded in it or attached to it. Examples include the plasma membrane and most organelle membranes." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0016020 ! membrane [Term] id: GO:0098813 name: nuclear chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process [Term] id: GO:0098827 name: endoplasmic reticulum subcompartment namespace: cellular_component def: "A distinct region of the endoplasmic reticulum" [GOC:dos] is_a: GO:0031984 ! organelle subcompartment intersection_of: GO:0031984 ! organelle subcompartment intersection_of: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0098840 name: protein transport along microtubule namespace: biological_process def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607] synonym: "microtubule-based protein transport" BROAD [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0099118 ! microtubule-based protein transport [Term] id: GO:0098857 name: membrane microdomain namespace: cellular_component def: "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820] is_a: GO:0098589 ! membrane region [Term] id: GO:0098984 name: neuron to neuron synapse namespace: cellular_component def: "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] is_a: GO:0045202 ! synapse [Term] id: GO:0099003 name: vesicle-mediated transport in synapse namespace: biological_process def: "Any vesicle-mediated transport that occurs in a synapse" [GOC:dos] subset: goslim_synapse is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: occurs_in GO:0045202 ! synapse relationship: occurs_in GO:0045202 ! synapse [Term] id: GO:0099091 name: postsynaptic specialization, intracellular component namespace: cellular_component def: "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] subset: goslim_synapse is_a: GO:0043228 ! non-membrane-bounded organelle intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0099572 ! postsynaptic specialization relationship: part_of GO:0099572 ! postsynaptic specialization [Term] id: GO:0099092 name: postsynaptic density, intracellular component namespace: cellular_component def: "A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] subset: goslim_synapse is_a: GO:0099091 ! postsynaptic specialization, intracellular component intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0014069 ! postsynaptic density relationship: part_of GO:0014069 ! postsynaptic density [Term] id: GO:0099111 name: microtubule-based transport namespace: biological_process def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006810 ! transport is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0099118 name: microtubule-based protein transport namespace: biological_process def: "A microtubule-based process that results in the transport of proteins." [GOC:vw] is_a: GO:0015031 ! protein transport is_a: GO:0099111 ! microtubule-based transport [Term] id: GO:0099503 name: secretory vesicle namespace: cellular_component def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] subset: goslim_drosophila is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0099522 name: region of cytosol namespace: cellular_component def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol" [GOC:dos] is_a: GO:0005829 ! cytosol intersection_of: GO:0005829 ! cytosol intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0099524 name: postsynaptic cytosol namespace: cellular_component def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0099522 ! region of cytosol intersection_of: GO:0005829 ! cytosol intersection_of: part_of GO:0005829 ! cytosol intersection_of: part_of GO:0098794 ! postsynapse relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0099536 name: synaptic signaling namespace: biological_process def: "Cell-cell signaling to, from or within a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: occurs_in GO:0045202 ! synapse relationship: occurs_in GO:0045202 ! synapse property_value: RO:0002161 NCBITaxon:4895 [Term] id: GO:0099568 name: cytoplasmic region namespace: cellular_component def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\"" [GOC:dos] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0099571 name: postsynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: part_of GO:0098794 ! postsynapse relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0099572 name: postsynaptic specialization namespace: cellular_component def: "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] subset: goslim_synapse is_a: GO:0043226 ! organelle relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0099643 name: signal release from synapse namespace: biological_process def: "Any signal release from a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0023061 ! signal release intersection_of: GO:0023061 ! signal release intersection_of: occurs_in GO:0045202 ! synapse relationship: occurs_in GO:0045202 ! synapse relationship: part_of GO:0099536 ! synaptic signaling [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plasma membrane" [GOC:dos] synonym: "perimembrane region" EXACT [] is_a: GO:0005938 ! cell cortex is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005938 ! cell cortex intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0100017 name: obsolete negative regulation of cell-cell adhesion by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates single organismal cell-cell adhesion" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100020 name: obsolete regulation of transport by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates transport" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100023 name: obsolete regulation of meiotic nuclear division by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates meiotic nuclear division" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100024 name: obsolete regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates carbohydrate metabolic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100036 name: obsolete positive regulation of purine nucleotide biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates purine nucleotide biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100051 name: obsolete positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates meiotic nuclear division" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0104004 name: cellular response to environmental stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] is_a: GO:0051716 ! cellular response to stimulus created_by: dos creation_date: 2017-02-17T16:02:42Z [Term] id: GO:0106014 name: regulation of inflammatory response to wounding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090594 ! inflammatory response to wounding relationship: regulates GO:0090594 ! inflammatory response to wounding created_by: hjd creation_date: 2017-04-28T20:03:14Z [Term] id: GO:0106015 name: negative regulation of inflammatory response to wounding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0106014 ! regulation of inflammatory response to wounding is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0090594 ! inflammatory response to wounding relationship: negatively_regulates GO:0090594 ! inflammatory response to wounding created_by: hjd creation_date: 2017-04-28T20:09:46Z [Term] id: GO:0106016 name: positive regulation of inflammatory response to wounding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0106014 ! regulation of inflammatory response to wounding is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0090594 ! inflammatory response to wounding relationship: positively_regulates GO:0090594 ! inflammatory response to wounding created_by: hjd creation_date: 2017-04-28T20:16:31Z [Term] id: GO:0106064 name: regulation of cobalamin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009235 ! cobalamin metabolic process relationship: regulates GO:0009235 ! cobalamin metabolic process created_by: hjd creation_date: 2017-10-27T17:33:05Z [Term] id: GO:0106121 name: positive regulation of cobalamin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0106064 ! regulation of cobalamin metabolic process is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009235 ! cobalamin metabolic process relationship: positively_regulates GO:0009235 ! cobalamin metabolic process created_by: hjd creation_date: 2018-05-01T18:07:12Z [Term] id: GO:0106122 name: negative regulation of cobalamin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0106064 ! regulation of cobalamin metabolic process is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009235 ! cobalamin metabolic process relationship: negatively_regulates GO:0009235 ! cobalamin metabolic process created_by: hjd creation_date: 2018-05-01T18:12:48Z [Term] id: GO:0110028 name: positive regulation of mitotic spindle organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle organization." [GOC:bhm, PMID:17576815] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060236 ! regulation of mitotic spindle organization is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007052 ! mitotic spindle organization relationship: positively_regulates GO:0007052 ! mitotic spindle organization created_by: kmv creation_date: 2017-07-06T14:14:08Z [Term] id: GO:0110110 name: positive regulation of animal organ morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009887 ! animal organ morphogenesis relationship: positively_regulates GO:0009887 ! animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:10:14Z [Term] id: GO:0110111 name: negative regulation of animal organ morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009887 ! animal organ morphogenesis relationship: negatively_regulates GO:0009887 ! animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:25:21Z [Term] id: GO:0110159 name: regulation of mitotic spindle formation (spindle phase one) namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] is_a: GO:0032888 ! regulation of mitotic spindle elongation is_a: GO:1901673 ! regulation of mitotic spindle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061804 ! mitotic spindle formation (spindle phase one) relationship: regulates GO:0061804 ! mitotic spindle formation (spindle phase one) created_by: kmv creation_date: 2019-08-12T15:10:26Z [Term] id: GO:0110160 name: negative regulation of mitotic spindle formation (spindle phase one) namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) is_a: GO:1902845 ! negative regulation of mitotic spindle elongation is_a: GO:1905831 ! negative regulation of spindle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) relationship: negatively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) created_by: kmv creation_date: 2019-08-12T15:18:32Z [Term] id: GO:0110161 name: positive regulation of mitotic spindle formation (spindle phase one) namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) is_a: GO:1902846 ! positive regulation of mitotic spindle elongation is_a: GO:1905832 ! positive regulation of spindle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) relationship: positively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) created_by: kmv creation_date: 2019-08-12T15:21:08Z [Term] id: GO:0110165 name: cellular anatomical entity namespace: cellular_component def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv] is_a: GO:0005575 ! cellular_component created_by: kmv creation_date: 2019-08-12T18:01:37Z [Term] id: GO:0120025 name: plasma membrane bounded cell projection namespace: cellular_component def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] is_a: GO:0042995 ! cell projection intersection_of: GO:0042995 ! cell projection intersection_of: has_part GO:0098590 ! plasma membrane region relationship: has_part GO:0098590 ! plasma membrane region created_by: kchris creation_date: 2017-03-21T17:26:07Z [Term] id: GO:0120031 name: plasma membrane bounded cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956] is_a: GO:0030031 ! cell projection assembly is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: kchris creation_date: 2017-04-24T23:56:08Z [Term] id: GO:0120032 name: regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: regulates GO:0120031 ! plasma membrane bounded cell projection assembly created_by: kchris creation_date: 2017-04-26T04:27:04Z [Term] id: GO:0120033 name: negative regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly created_by: kchris creation_date: 2017-04-26T04:34:31Z [Term] id: GO:0120034 name: positive regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly created_by: kchris creation_date: 2017-04-26T04:34:45Z [Term] id: GO:0120035 name: regulation of plasma membrane bounded cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] is_a: GO:0031344 ! regulation of cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120036 ! plasma membrane bounded cell projection organization relationship: regulates GO:0120036 ! plasma membrane bounded cell projection organization created_by: kchris creation_date: 2017-04-26T16:02:06Z [Term] id: GO:0120036 name: plasma membrane bounded cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_a: GO:0030030 ! cell projection organization created_by: kchris creation_date: 2017-04-26T16:07:02Z [Term] id: GO:0120038 name: obsolete plasma membrane bounded cell projection part namespace: cellular_component def: "OBSOLETE. Any constituent part of a plasma membrane bounded cell projection, a prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_obsolete: true consider: GO:0120025 created_by: kchris creation_date: 2017-04-28T17:20:43Z [Term] id: GO:0120111 name: neuron projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0043005 ! neuron projection relationship: part_of GO:0043005 ! neuron projection created_by: kchris creation_date: 2017-11-01T18:58:12Z [Term] id: GO:0140013 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] is_a: GO:0000280 ! nuclear division is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: pg creation_date: 2017-03-23T09:40:00Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic is_a: GO:0000280 ! nuclear division is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: pg creation_date: 2017-03-23T14:44:23Z [Term] id: GO:0140039 name: cell-cell adhesion in response to extracellular stimulus namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus." [PMID:14996911] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: part_of GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0031668 ! cellular response to extracellular stimulus created_by: pg creation_date: 2017-05-24T11:37:30Z [Term] id: GO:0140053 name: mitochondrial gene expression namespace: biological_process def: "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308] subset: goslim_pombe is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion created_by: pg creation_date: 2017-06-26T10:57:45Z [Term] id: GO:0140056 name: organelle localization by membrane tethering namespace: biological_process def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684] subset: goslim_pombe is_a: GO:0022406 ! membrane docking is_a: GO:0051640 ! organelle localization created_by: pg creation_date: 2017-06-27T09:58:51Z [Term] id: GO:0140096 name: catalytic activity, acting on a protein namespace: molecular_function def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] is_a: GO:0003824 ! catalytic activity property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI created_by: pg creation_date: 2017-09-14T10:32:59Z [Term] id: GO:0140112 name: extracellular vesicle biogenesis namespace: biological_process def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435] synonym: "extracellular vesicle assembly" EXACT [] is_a: GO:0044085 ! cellular component biogenesis property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14256 xsd:anyURI created_by: pg creation_date: 2017-10-23T11:53:42Z [Term] id: GO:0140297 name: DNA-binding transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] is_a: GO:0008134 ! transcription factor binding created_by: pg creation_date: 2018-11-28T12:48:20Z [Term] id: GO:0140321 name: negative regulation by symbiont of host autophagy namespace: biological_process def: "Any process in which a symbiont organism decreases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pg] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0075071 ! modulation by symbiont of host autophagy intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: negatively_regulates GO:0006914 ! autophagy created_by: pg creation_date: 2019-04-03T09:21:48Z [Term] id: GO:0140352 name: export from cell namespace: biological_process def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process created_by: pg creation_date: 2019-05-22T11:20:45Z [Term] id: GO:1900046 name: regulation of hemostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemostasis." [GOC:TermGenie] is_a: GO:0050789 ! regulation of biological process is_a: GO:0050878 ! regulation of body fluid levels intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007599 ! hemostasis relationship: regulates GO:0007599 ! hemostasis created_by: jl creation_date: 2012-01-19T03:23:38Z [Term] id: GO:1900047 name: negative regulation of hemostasis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." [GOC:TermGenie] synonym: "down regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "downregulation of hemostasis" EXACT [GOC:TermGenie] synonym: "inhibition of hemostasis" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007599 ! hemostasis relationship: negatively_regulates GO:0007599 ! hemostasis created_by: jl creation_date: 2012-01-19T03:23:42Z [Term] id: GO:1900048 name: positive regulation of hemostasis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemostasis." [GOC:TermGenie] synonym: "activation of hemostasis" NARROW [GOC:TermGenie] synonym: "up regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "upregulation of hemostasis" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007599 ! hemostasis relationship: positively_regulates GO:0007599 ! hemostasis created_by: jl creation_date: 2012-01-19T03:23:45Z [Term] id: GO:1900115 name: extracellular regulation of signal transduction namespace: biological_process def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0009966 ! regulation of signal transduction intersection_of: occurs_in GO:0005576 ! extracellular region relationship: occurs_in GO:0005576 ! extracellular region created_by: bf creation_date: 2012-02-22T10:21:48Z [Term] id: GO:1900116 name: extracellular negative regulation of signal transduction namespace: biological_process def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf] synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie] synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900115 ! extracellular regulation of signal transduction intersection_of: GO:0009968 ! negative regulation of signal transduction intersection_of: occurs_in GO:0005576 ! extracellular region created_by: bf creation_date: 2012-02-22T10:27:56Z [Term] id: GO:1900117 name: regulation of execution phase of apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097194 ! execution phase of apoptosis relationship: regulates GO:0097194 ! execution phase of apoptosis created_by: pr creation_date: 2012-02-22T11:26:20Z [Term] id: GO:1900118 name: negative regulation of execution phase of apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097194 ! execution phase of apoptosis relationship: negatively_regulates GO:0097194 ! execution phase of apoptosis created_by: pr creation_date: 2012-02-22T11:26:24Z [Term] id: GO:1900119 name: positive regulation of execution phase of apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097194 ! execution phase of apoptosis relationship: positively_regulates GO:0097194 ! execution phase of apoptosis created_by: pr creation_date: 2012-02-22T11:26:27Z [Term] id: GO:1900120 name: regulation of receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005102 ! signaling receptor binding relationship: regulates GO:0005102 ! signaling receptor binding created_by: bf creation_date: 2012-02-22T11:40:53Z [Term] id: GO:1900121 name: negative regulation of receptor binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie] synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie] synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005102 ! signaling receptor binding relationship: negatively_regulates GO:0005102 ! signaling receptor binding created_by: bf creation_date: 2012-02-22T11:40:57Z [Term] id: GO:1900122 name: positive regulation of receptor binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] synonym: "activation of receptor binding" NARROW [GOC:TermGenie] synonym: "up regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of receptor binding" EXACT [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005102 ! signaling receptor binding relationship: positively_regulates GO:0005102 ! signaling receptor binding created_by: bf creation_date: 2012-02-22T11:41:00Z [Term] id: GO:1900160 name: plastid DNA packaging namespace: biological_process def: "Any process in which plastidial DNA and associated proteins are formed into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370] synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie] synonym: "DNA organization in plastid" EXACT [GOC:TermGenie] synonym: "plastidial DNA packaging" EXACT [GOC:emb] is_a: GO:0036385 ! nucleoid DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0009536 ! plastid relationship: occurs_in GO:0009536 ! plastid property_value: RO:0002161 NCBITaxon:2 property_value: RO:0002161 NCBITaxon:2157 property_value: RO:0002161 NCBITaxon:28009 property_value: RO:0002161 NCBITaxon:33208 property_value: RO:0002161 NCBITaxon:4751 property_value: RO:0002161 NCBITaxon:554915 created_by: bf creation_date: 2012-03-08T10:51:50Z [Term] id: GO:1900190 name: regulation of single-species biofilm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044010 ! single-species biofilm formation relationship: regulates GO:0044010 ! single-species biofilm formation created_by: di creation_date: 2012-03-19T12:42:04Z [Term] id: GO:1900191 name: negative regulation of single-species biofilm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] synonym: "down regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "downregulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "inhibition of single-species biofilm formation" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044010 ! single-species biofilm formation relationship: negatively_regulates GO:0044010 ! single-species biofilm formation created_by: di creation_date: 2012-03-19T12:42:13Z [Term] id: GO:1900192 name: positive regulation of single-species biofilm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] synonym: "activation of single-species biofilm formation" NARROW [GOC:TermGenie] synonym: "up regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "upregulation of single-species biofilm formation" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044010 ! single-species biofilm formation relationship: positively_regulates GO:0044010 ! single-species biofilm formation created_by: di creation_date: 2012-03-19T12:42:21Z [Term] id: GO:1900231 name: regulation of single-species biofilm formation on inanimate substrate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate relationship: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate created_by: di creation_date: 2012-03-23T04:40:35Z [Term] id: GO:1900232 name: negative regulation of single-species biofilm formation on inanimate substrate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] synonym: "down regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "down-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "downregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "inhibition of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie] is_a: GO:1900191 ! negative regulation of single-species biofilm formation is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate relationship: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate created_by: di creation_date: 2012-03-23T04:40:45Z [Term] id: GO:1900233 name: positive regulation of single-species biofilm formation on inanimate substrate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] synonym: "activation of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie] synonym: "up regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "up-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "upregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] is_a: GO:1900192 ! positive regulation of single-species biofilm formation is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate relationship: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate created_by: di creation_date: 2012-03-23T04:40:53Z [Term] id: GO:1900368 name: regulation of RNA interference namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] synonym: "regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "regulation of RNAi" EXACT [GOC:TermGenie] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0060966 ! regulation of gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016246 ! RNA interference relationship: regulates GO:0016246 ! RNA interference created_by: kmv creation_date: 2012-04-13T08:28:39Z [Term] id: GO:1900369 name: negative regulation of RNA interference namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] synonym: "down regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "down regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "down regulation of RNAi" EXACT [GOC:TermGenie] synonym: "down-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "down-regulation of RNAi" EXACT [GOC:TermGenie] synonym: "downregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "downregulation of RNA interference" EXACT [GOC:TermGenie] synonym: "downregulation of RNAi" EXACT [GOC:TermGenie] synonym: "inhibition of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "inhibition of RNA interference" NARROW [GOC:TermGenie] synonym: "inhibition of RNAi" EXACT [GOC:TermGenie] synonym: "negative regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "negative regulation of RNAi" EXACT [GOC:TermGenie] is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing is_a: GO:0060967 ! negative regulation of gene silencing by RNA is_a: GO:1900368 ! regulation of RNA interference intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016246 ! RNA interference relationship: negatively_regulates GO:0016246 ! RNA interference created_by: kmv creation_date: 2012-04-13T08:28:50Z [Term] id: GO:1900370 name: positive regulation of RNA interference namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] synonym: "activation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "activation of RNA interference" NARROW [GOC:TermGenie] synonym: "activation of RNAi" EXACT [GOC:TermGenie] synonym: "positive regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "positive regulation of RNAi" EXACT [GOC:TermGenie] synonym: "up regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "up regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "up regulation of RNAi" EXACT [GOC:TermGenie] synonym: "up-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "up-regulation of RNAi" EXACT [GOC:TermGenie] synonym: "upregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "upregulation of RNA interference" EXACT [GOC:TermGenie] synonym: "upregulation of RNAi" EXACT [GOC:TermGenie] is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing is_a: GO:1900368 ! regulation of RNA interference intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016246 ! RNA interference relationship: positively_regulates GO:0016246 ! RNA interference created_by: kmv creation_date: 2012-04-13T08:29:00Z [Term] id: GO:1900371 name: regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006164 ! purine nucleotide biosynthetic process relationship: regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: krc creation_date: 2012-04-17T12:32:07Z [Term] id: GO:1900372 name: negative regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "down regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process relationship: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: krc creation_date: 2012-04-17T12:32:27Z [Term] id: GO:1900373 name: positive regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "activation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: krc creation_date: 2012-04-17T12:32:37Z [Term] id: GO:1900387 name: obsolete negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cell-cell adhesion." [GOC:BHF, GOC:TermGenie, PMID:15737616] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: pr creation_date: 2012-04-18T12:01:19Z [Term] id: GO:1900392 name: obsolete regulation of transport by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in regulation of transport." [GOC:mah, GOC:TermGenie, PMID:17446861] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: mah creation_date: 2012-04-18T04:20:25Z [Term] id: GO:1900402 name: obsolete regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate metabolic process." [GOC:mah, GOC:TermGenie, PMID:16408318] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of carbohydrate metabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-20T02:45:27Z [Term] id: GO:1900418 name: obsolete positive regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of purine nucleotide biosynthetic process." [GOC:curators, GOC:TermGenie, PMID:17573544] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: krc creation_date: 2012-04-20T10:13:58Z [Term] id: GO:1900542 name: regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0006140 ! regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006163 ! purine nucleotide metabolic process relationship: regulates GO:0006163 ! purine nucleotide metabolic process created_by: krc creation_date: 2012-05-11T05:43:15Z [Term] id: GO:1900543 name: negative regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "down regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "down regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "down regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "down-regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "down-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "downregulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "downregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of purine metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "negative regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0045980 ! negative regulation of nucleotide metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006163 ! purine nucleotide metabolic process relationship: negatively_regulates GO:0006163 ! purine nucleotide metabolic process created_by: krc creation_date: 2012-05-11T05:44:21Z [Term] id: GO:1900544 name: positive regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "activation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "activation of purine metabolism" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "positive regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "up regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "up-regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "up-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "upregulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "upregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0045981 ! positive regulation of nucleotide metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006163 ! purine nucleotide metabolic process relationship: positively_regulates GO:0006163 ! purine nucleotide metabolic process created_by: krc creation_date: 2012-05-11T05:44:43Z [Term] id: GO:1901000 name: regulation of response to salt stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] synonym: "regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "regulation of salinity response" EXACT [GOC:TermGenie] is_a: GO:0047484 ! regulation of response to osmotic stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009651 ! response to salt stress relationship: regulates GO:0009651 ! response to salt stress created_by: dhl creation_date: 2012-06-14T05:41:19Z [Term] id: GO:1901001 name: negative regulation of response to salt stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] synonym: "down regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "down regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "down regulation of salinity response" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "down-regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "down-regulation of salinity response" EXACT [GOC:TermGenie] synonym: "downregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "downregulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "downregulation of salinity response" EXACT [GOC:TermGenie] synonym: "inhibition of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "inhibition of response to salt stress" NARROW [GOC:TermGenie] synonym: "inhibition of salinity response" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "negative regulation of salinity response" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901000 ! regulation of response to salt stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009651 ! response to salt stress relationship: negatively_regulates GO:0009651 ! response to salt stress created_by: dhl creation_date: 2012-06-14T05:41:43Z [Term] id: GO:1901002 name: positive regulation of response to salt stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] synonym: "activation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "activation of response to salt stress" NARROW [GOC:TermGenie] synonym: "activation of salinity response" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "positive regulation of salinity response" EXACT [GOC:TermGenie] synonym: "up regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "up regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "up regulation of salinity response" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "up-regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "up-regulation of salinity response" EXACT [GOC:TermGenie] synonym: "upregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "upregulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "upregulation of salinity response" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901000 ! regulation of response to salt stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009651 ! response to salt stress relationship: positively_regulates GO:0009651 ! response to salt stress created_by: dhl creation_date: 2012-06-14T05:41:50Z [Term] id: GO:1901135 name: carbohydrate derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] subset: goslim_agr subset: goslim_mouse synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: bf creation_date: 2012-07-12T04:05:09Z [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: bf creation_date: 2012-07-12T04:05:39Z [Term] id: GO:1901148 name: gene expression involved in extracellular matrix organization namespace: biological_process def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558] synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf] synonym: "extracellular matrix protein production" RELATED [GOC:pg] is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: part_of GO:0030198 ! extracellular matrix organization relationship: part_of GO:0030198 ! extracellular matrix organization created_by: bf creation_date: 2012-07-16T03:29:30Z [Term] id: GO:1901293 name: nucleoside phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] synonym: "nucleoside phosphate anabolism" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate formation" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0006753 ! nucleoside phosphate metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process created_by: bf creation_date: 2012-08-20T12:33:45Z [Term] id: GO:1901317 name: regulation of flagellated sperm motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "regulation of sperm motility" BROAD [] synonym: "regulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030317 ! flagellated sperm motility relationship: regulates GO:0030317 ! flagellated sperm motility created_by: hjd creation_date: 2012-08-22T20:50:14Z [Term] id: GO:1901318 name: negative regulation of flagellated sperm motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "down regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "down regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "down-regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "down-regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "downregulation of sperm motility" BROAD [GOC:TermGenie] synonym: "downregulation of sperm movement" BROAD [GOC:TermGenie] synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie] synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie] synonym: "negative regulation of sperm motility" BROAD [] synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030317 ! flagellated sperm motility relationship: negatively_regulates GO:0030317 ! flagellated sperm motility created_by: hjd creation_date: 2012-08-22T20:50:35Z [Term] id: GO:1901342 name: regulation of vasculature development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001944 ! vasculature development relationship: regulates GO:0001944 ! vasculature development created_by: bf creation_date: 2012-09-06T09:16:15Z [Term] id: GO:1901343 name: negative regulation of vasculature development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie] synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie] synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001944 ! vasculature development relationship: negatively_regulates GO:0001944 ! vasculature development created_by: bf creation_date: 2012-09-06T09:17:24Z [Term] id: GO:1901360 name: organic cyclic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: bf creation_date: 2012-09-14T09:03:51Z [Term] id: GO:1901362 name: organic cyclic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie] synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: bf creation_date: 2012-09-14T09:05:22Z [Term] id: GO:1901363 name: heterocyclic compound binding namespace: molecular_function def: "Interacting selectively and non-covalently with heterocyclic compound." [GOC:TermGenie] is_a: GO:0005488 ! binding created_by: bf creation_date: 2012-09-14T13:53:50Z [Term] id: GO:1901401 name: regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033013 ! tetrapyrrole metabolic process relationship: regulates GO:0033013 ! tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:34:03Z [Term] id: GO:1901402 name: negative regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process relationship: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:35:11Z [Term] id: GO:1901403 name: positive regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033013 ! tetrapyrrole metabolic process relationship: positively_regulates GO:0033013 ! tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:35:29Z [Term] id: GO:1901419 name: regulation of response to alcohol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097305 ! response to alcohol relationship: regulates GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T16:52:13Z [Term] id: GO:1901420 name: negative regulation of response to alcohol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "down-regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "downregulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "inhibition of response to alcohol" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097305 ! response to alcohol relationship: negatively_regulates GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T16:53:25Z [Term] id: GO:1901421 name: positive regulation of response to alcohol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to alcohol" NARROW [GOC:TermGenie] synonym: "up regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "up-regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "upregulation of response to alcohol" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097305 ! response to alcohol relationship: positively_regulates GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T16:53:42Z [Term] id: GO:1901522 name: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777] synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0070887 ! cellular response to chemical stimulus created_by: al creation_date: 2012-10-19T08:25:05Z [Term] id: GO:1901538 name: changes to DNA methylation involved in embryo development namespace: biological_process def: "The addition or removal of methyl groups to DNA that contributes to the epigenetic regulation of embryonic gene expression." [GOC:TermGenie] synonym: "changes in DNA methylation involved in embryo development" EXACT [GOC:TermGenie] synonym: "changes in DNA methylation involved in embryogenesis" EXACT [GOC:TermGenie] synonym: "changes in DNA methylation involved in embryonal development" RELATED [GOC:TermGenie] synonym: "DNA methylation or demethylation involved in embryogenesis" EXACT [GOC:TermGenie] synonym: "DNA methylation or demethylation involved in embryonal development" EXACT [GOC:TermGenie] is_a: GO:0044728 ! DNA methylation or demethylation intersection_of: GO:0044728 ! DNA methylation or demethylation intersection_of: part_of GO:0009790 ! embryo development relationship: part_of GO:0009790 ! embryo development created_by: jl creation_date: 2012-10-25T14:53:43Z [Term] id: GO:1901554 name: response to paracetamol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus." [GOC:TermGenie] synonym: "response to acetaminophen" EXACT [] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:43:23Z [Term] id: GO:1901555 name: response to paclitaxel namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GOC:TermGenie] is_a: GO:0033993 ! response to lipid is_a: GO:0097327 ! response to antineoplastic agent created_by: hp creation_date: 2012-11-02T09:46:08Z [Term] id: GO:1901556 name: response to candesartan namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus." [GOC:TermGenie] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:46:13Z [Term] id: GO:1901557 name: response to fenofibrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus." [GOC:TermGenie] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0045472 ! response to ether is_a: GO:1901654 ! response to ketone created_by: hp creation_date: 2012-11-02T09:46:20Z [Term] id: GO:1901558 name: response to metformin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus." [GOC:TermGenie] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0042493 ! response to drug created_by: hp creation_date: 2012-11-02T09:46:24Z [Term] id: GO:1901559 name: response to ribavirin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0061479 ! response to reverse transcriptase inhibitor is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:46:28Z [Term] id: GO:1901563 name: response to camptothecin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] synonym: "response to CPT" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent created_by: mah creation_date: 2012-11-02T15:32:45Z [Term] id: GO:1901564 name: organonitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-04T15:17:52Z [Term] id: GO:1901566 name: organonitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie] synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie] synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: pr creation_date: 2012-11-04T15:18:00Z [Term] id: GO:1901576 name: organic substance biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthetic process" EXACT [] synonym: "organic molecular entity formation" EXACT [GOC:TermGenie] synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie] synonym: "organic substance anabolism" EXACT [] synonym: "organic substance biosynthesis" EXACT [] synonym: "organic substance formation" EXACT [] synonym: "organic substance synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-05T11:04:40Z [Term] id: GO:1901615 name: organic hydroxy compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-13T12:54:27Z [Term] id: GO:1901654 name: response to ketone namespace: biological_process alt_id: GO:1990369 def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] synonym: "process resulting in tolerance to ketone" NARROW [] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-11-20T10:55:47Z [Term] id: GO:1901657 name: glycosyl compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie] synonym: "glycosyl compound metabolism" EXACT [GOC:TermGenie] is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: pr creation_date: 2012-11-20T14:24:07Z [Term] id: GO:1901659 name: glycosyl compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosyl compound." [GOC:pr, GOC:TermGenie] synonym: "glycosyl compound anabolism" EXACT [GOC:TermGenie] synonym: "glycosyl compound biosynthesis" EXACT [GOC:TermGenie] synonym: "glycosyl compound formation" EXACT [GOC:TermGenie] synonym: "glycosyl compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901657 ! glycosyl compound metabolic process created_by: pr creation_date: 2012-11-20T14:24:19Z [Term] id: GO:1901673 name: regulation of mitotic spindle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie] synonym: "regulation of spindle assembly involved in mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0060236 ! regulation of mitotic spindle organization is_a: GO:0090169 ! regulation of spindle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090307 ! mitotic spindle assembly relationship: regulates GO:0090307 ! mitotic spindle assembly created_by: al creation_date: 2012-11-22T09:50:00Z [Term] id: GO:1901698 name: response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to nitrogen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical created_by: pr creation_date: 2012-12-13T15:06:08Z [Term] id: GO:1901700 name: response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to oxygen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical created_by: pr creation_date: 2012-12-13T15:11:37Z [Term] id: GO:1901731 name: positive regulation of platelet aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:fj, GOC:TermGenie] synonym: "activation of blood platelet aggregation" NARROW [GOC:TermGenie] synonym: "activation of platelet aggregation" NARROW [GOC:TermGenie] synonym: "activation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "positive regulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "positive regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "up regulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "up regulation of platelet aggregation" EXACT [GOC:TermGenie] synonym: "up regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "up-regulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "up-regulation of platelet aggregation" EXACT [GOC:TermGenie] synonym: "up-regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "upregulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "upregulation of platelet aggregation" EXACT [GOC:TermGenie] synonym: "upregulation of thrombocyte aggregation" RELATED [GOC:TermGenie] is_a: GO:0010572 ! positive regulation of platelet activation is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion is_a: GO:0090330 ! regulation of platelet aggregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070527 ! platelet aggregation relationship: positively_regulates GO:0070527 ! platelet aggregation created_by: pr creation_date: 2013-01-10T13:25:39Z [Term] id: GO:1901738 name: regulation of vitamin A metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vitamin A metabolic process." [GOC:TermGenie, PMID:18093975] synonym: "regulation of vitamin A metabolism" EXACT [GOC:TermGenie] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006776 ! vitamin A metabolic process relationship: regulates GO:0006776 ! vitamin A metabolic process created_by: dph creation_date: 2013-01-11T15:29:43Z [Term] id: GO:1901858 name: regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032042 ! mitochondrial DNA metabolic process relationship: regulates GO:0032042 ! mitochondrial DNA metabolic process created_by: yaf creation_date: 2013-02-01T10:05:04Z [Term] id: GO:1901859 name: negative regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process relationship: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process created_by: yaf creation_date: 2013-02-01T10:05:09Z [Term] id: GO:1901860 name: positive regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process relationship: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process created_by: yaf creation_date: 2013-02-01T10:05:14Z [Term] id: GO:1901905 name: response to tamsulosin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tamsulosin stimulus." [GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0014075 ! response to amine is_a: GO:0045472 ! response to ether is_a: GO:0097327 ! response to antineoplastic agent created_by: hp creation_date: 2013-02-13T10:14:41Z [Term] id: GO:1902017 name: regulation of cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060271 ! cilium assembly relationship: regulates GO:0060271 ! cilium assembly created_by: dph creation_date: 2013-03-26T18:10:51Z [Term] id: GO:1902018 name: negative regulation of cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060271 ! cilium assembly relationship: negatively_regulates GO:0060271 ! cilium assembly created_by: dph creation_date: 2013-03-26T18:10:56Z [Term] id: GO:1902019 name: regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "regulation of ciliary cell motility" RELATED [] synonym: "regulation of cilium cell motility" EXACT [] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060285 ! cilium-dependent cell motility relationship: regulates GO:0060285 ! cilium-dependent cell motility created_by: jl creation_date: 2013-03-27T14:42:38Z [Term] id: GO:1902020 name: negative regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie] synonym: "negative regulation of ciliary cell motility" RELATED [] synonym: "negative regulation of cilium cell motility" EXACT [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060285 ! cilium-dependent cell motility relationship: negatively_regulates GO:0060285 ! cilium-dependent cell motility created_by: jl creation_date: 2013-03-27T14:42:42Z [Term] id: GO:1902064 name: regulation of transcription from RNA polymerase II promoter involved in spermatogenesis namespace: biological_process def: "Any regulation of transcription from RNA polymerase II promoter that is involved in spermatogenesis." [GOC:kmv, GOC:TermGenie, PMID:22570621] synonym: "global transcription regulation from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in spermatogenesis" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in spermatogenesis" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0022414 ! reproductive process intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007283 ! spermatogenesis relationship: part_of GO:0007283 ! spermatogenesis created_by: kmv creation_date: 2013-04-16T20:27:18Z [Term] id: GO:1902074 name: response to salt namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] synonym: "response to salinity" NARROW [GOC:mls] is_a: GO:0042221 ! response to chemical created_by: mls creation_date: 2013-04-22T15:41:57Z [Term] id: GO:1902093 name: positive regulation of flagellated sperm motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657] synonym: "activation of sperm motility" NARROW [GOC:TermGenie] synonym: "activation of sperm movement" BROAD [GOC:TermGenie] synonym: "positive regulation of sperm motility" BROAD [] synonym: "positive regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "up regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "up regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie] synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030317 ! flagellated sperm motility relationship: positively_regulates GO:0030317 ! flagellated sperm motility created_by: bf creation_date: 2013-04-29T09:15:25Z [Term] id: GO:1902115 name: regulation of organelle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070925 ! organelle assembly relationship: regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:21Z [Term] id: GO:1902116 name: negative regulation of organelle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070925 ! organelle assembly relationship: negatively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:31Z [Term] id: GO:1902117 name: positive regulation of organelle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070925 ! organelle assembly relationship: positively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:36Z [Term] id: GO:1902119 name: regulation of meiotic spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392] synonym: "regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] is_a: GO:0032887 ! regulation of spindle elongation is_a: GO:0040020 ! regulation of meiotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051232 ! meiotic spindle elongation relationship: regulates GO:0051232 ! meiotic spindle elongation created_by: al creation_date: 2013-05-15T15:15:48Z [Term] id: GO:1902120 name: negative regulation of meiotic spindle elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392] synonym: "down regulation of meiotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic spindle elongation" EXACT [GOC:TermGenie] synonym: "downregulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic spindle elongation" NARROW [GOC:TermGenie] synonym: "inhibition of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] is_a: GO:0045835 ! negative regulation of meiotic nuclear division is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:1902119 ! regulation of meiotic spindle elongation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051232 ! meiotic spindle elongation relationship: negatively_regulates GO:0051232 ! meiotic spindle elongation created_by: al creation_date: 2013-05-15T15:15:53Z [Term] id: GO:1902262 name: apoptotic process involved in blood vessel morphogenesis namespace: biological_process def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358] synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis created_by: dph creation_date: 2013-06-25T16:16:00Z [Term] id: GO:1902337 name: regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:16Z [Term] id: GO:1902338 name: negative regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:25Z [Term] id: GO:1902339 name: positive regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:33Z [Term] id: GO:1902340 name: negative regulation of chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725] synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030261 ! chromosome condensation relationship: negatively_regulates GO:0030261 ! chromosome condensation created_by: dgf creation_date: 2013-07-29T20:54:14Z [Term] id: GO:1902518 name: response to cyclophosphamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0097327 ! response to antineoplastic agent created_by: dw creation_date: 2013-12-02T09:34:08Z [Term] id: GO:1902519 name: response to docetaxel trihydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to docetaxel" RELATED [] is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: dw creation_date: 2013-12-02T09:44:04Z [Term] id: GO:1902520 name: response to doxorubicin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1903416 ! response to glycoside created_by: dw creation_date: 2013-12-02T09:44:13Z [Term] id: GO:1902521 name: response to etoposide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1904631 ! response to glucoside created_by: dw creation_date: 2013-12-02T09:44:22Z [Term] id: GO:1902522 name: response to 4'-epidoxorubicin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to epirubicin" RELATED [] is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1903416 ! response to glycoside created_by: dw creation_date: 2013-12-02T09:44:31Z [Term] id: GO:1902531 name: regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010627 def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "regulation of intracellular protein kinase cascade" NARROW [] synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035556 ! intracellular signal transduction relationship: regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:32:52Z [Term] id: GO:1902532 name: negative regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010741 def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular protein kinase cascade" EXACT [] synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035556 ! intracellular signal transduction relationship: negatively_regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:01Z [Term] id: GO:1902533 name: positive regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010740 def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular protein kinase cascade" NARROW [] synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035556 ! intracellular signal transduction relationship: positively_regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:10Z [Term] id: GO:1902579 name: multi-organism localization namespace: biological_process def: "A localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "multi organism localization" EXACT [GOC:TermGenie] is_a: GO:0051179 ! localization is_a: GO:0051704 ! multi-organism process created_by: jl creation_date: 2013-12-18T13:51:13Z [Term] id: GO:1902581 name: multi-organism cellular localization namespace: biological_process def: "A cellular localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "multi organism cellular localization" EXACT [GOC:TermGenie] is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0051641 ! cellular localization is_a: GO:1902579 ! multi-organism localization created_by: jl creation_date: 2013-12-18T14:04:41Z [Term] id: GO:1902583 name: obsolete multi-organism intracellular transport namespace: biological_process def: "OBSOLETE. An intracellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "multi organism intracellular transport" EXACT [GOC:TermGenie] is_obsolete: true created_by: jl creation_date: 2013-12-18T14:04:58Z [Term] id: GO:1902584 name: positive regulation of response to water deprivation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to water deprivation." [GO_REF:0000058, GOC:TermGenie, PMID:24198318] synonym: "activation of drought tolerance" RELATED [GOC:TermGenie] synonym: "activation of response to dehydration" NARROW [GOC:TermGenie] synonym: "activation of response to drought" NARROW [GOC:TermGenie] synonym: "activation of response to thirst" NARROW [GOC:TermGenie] synonym: "activation of response to water deprivation" NARROW [GOC:TermGenie] synonym: "positive regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "positive regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "positive regulation of response to drought" EXACT [GOC:TermGenie] synonym: "positive regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "up regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "up regulation of response to drought" EXACT [GOC:TermGenie] synonym: "up regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up regulation of response to water deprivation" EXACT [GOC:TermGenie] synonym: "up-regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "up-regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "up-regulation of response to drought" EXACT [GOC:TermGenie] synonym: "up-regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up-regulation of response to water deprivation" EXACT [GOC:TermGenie] synonym: "upregulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "upregulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "upregulation of response to drought" EXACT [GOC:TermGenie] synonym: "upregulation of response to thirst" EXACT [GOC:TermGenie] synonym: "upregulation of response to water deprivation" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000070 ! regulation of response to water deprivation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009414 ! response to water deprivation relationship: positively_regulates GO:0009414 ! response to water deprivation created_by: tb creation_date: 2013-12-19T00:31:58Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032774 ! RNA biosynthetic process relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032774 ! RNA biosynthetic process relationship: positively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1902742 name: apoptotic process involved in development namespace: biological_process def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic process involved in anatomical structure development" EXACT [] synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0048856 ! anatomical structure development relationship: part_of GO:0048856 ! anatomical structure development created_by: pr creation_date: 2014-02-28T13:09:43Z [Term] id: GO:1902845 name: negative regulation of mitotic spindle elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "down regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "downregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic spindle elongation" NARROW [GOC:TermGenie] synonym: "inhibition of spindle elongation during mitosis" NARROW [GOC:TermGenie] synonym: "negative regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] is_a: GO:0032888 ! regulation of mitotic spindle elongation is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000022 ! mitotic spindle elongation relationship: negatively_regulates GO:0000022 ! mitotic spindle elongation created_by: vw creation_date: 2014-04-02T08:43:28Z [Term] id: GO:1902846 name: positive regulation of mitotic spindle elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "activation of mitotic spindle elongation" NARROW [GOC:TermGenie] synonym: "activation of spindle elongation during mitosis" NARROW [GOC:TermGenie] synonym: "positive regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "up regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "upregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] is_a: GO:0032888 ! regulation of mitotic spindle elongation is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation is_a: GO:0110028 ! positive regulation of mitotic spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000022 ! mitotic spindle elongation relationship: positively_regulates GO:0000022 ! mitotic spindle elongation created_by: vw creation_date: 2014-04-02T08:43:34Z [Term] id: GO:1902850 name: microtubule cytoskeleton organization involved in mitosis namespace: biological_process def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: vw creation_date: 2014-04-02T14:19:38Z [Term] id: GO:1902902 name: negative regulation of autophagosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly." [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012] synonym: "down regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] synonym: "down regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "down regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "down regulation of PAS formation" NARROW [GOC:TermGenie] synonym: "down-regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "down-regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "down-regulation of PAS formation" NARROW [GOC:TermGenie] synonym: "downregulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] synonym: "downregulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "downregulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "downregulation of PAS formation" NARROW [GOC:TermGenie] synonym: "inhibition of autophagic vacuole assembly" NARROW [GOC:TermGenie] synonym: "inhibition of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "inhibition of autophagosome biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of autophagosome formation" NARROW [GOC:TermGenie] synonym: "inhibition of PAS formation" NARROW [GOC:TermGenie] synonym: "negative regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "negative regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "negative regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "negative regulation of PAS formation" NARROW [GOC:TermGenie] is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:2000785 ! regulation of autophagosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000045 ! autophagosome assembly relationship: negatively_regulates GO:0000045 ! autophagosome assembly created_by: als creation_date: 2014-04-15T10:37:40Z [Term] id: GO:1903018 name: regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009100 ! glycoprotein metabolic process relationship: regulates GO:0009100 ! glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:19Z [Term] id: GO:1903019 name: negative regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009100 ! glycoprotein metabolic process relationship: negatively_regulates GO:0009100 ! glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:25Z [Term] id: GO:1903020 name: positive regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009100 ! glycoprotein metabolic process relationship: positively_regulates GO:0009100 ! glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:31Z [Term] id: GO:1903034 name: regulation of response to wounding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009611 ! response to wounding relationship: regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:46Z [Term] id: GO:1903035 name: negative regulation of response to wounding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "down regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of response to wounding" EXACT [GOC:TermGenie] synonym: "inhibition of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "inhibition of response to wounding" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009611 ! response to wounding relationship: negatively_regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:52Z [Term] id: GO:1903036 name: positive regulation of response to wounding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "activation of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "activation of response to wounding" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009611 ! response to wounding relationship: positively_regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:58Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate subset: goslim_pombe is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0051321 ! meiotic cell cycle disjoint_from: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903047 name: mitotic cell cycle process namespace: biological_process def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:34Z [Term] id: GO:1903053 name: regulation of extracellular matrix organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030198 ! extracellular matrix organization relationship: regulates GO:0030198 ! extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:41Z [Term] id: GO:1903054 name: negative regulation of extracellular matrix organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030198 ! extracellular matrix organization relationship: negatively_regulates GO:0030198 ! extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:47Z [Term] id: GO:1903055 name: positive regulation of extracellular matrix organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030198 ! extracellular matrix organization relationship: positively_regulates GO:0030198 ! extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:53Z [Term] id: GO:1903108 name: regulation of mitochondrial transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609] synonym: "regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "regulation of transcription from mitochondrial promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0062125 ! regulation of mitochondrial gene expression intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006390 ! mitochondrial transcription relationship: regulates GO:0006390 ! mitochondrial transcription created_by: al creation_date: 2014-06-09T11:53:14Z [Term] id: GO:1903109 name: positive regulation of mitochondrial transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609] synonym: "activation of mitochondrial transcription" NARROW [GOC:TermGenie] synonym: "activation of transcription from mitochondrial promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from mitochondrial promoter" EXACT [] synonym: "up regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:1903108 ! regulation of mitochondrial transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006390 ! mitochondrial transcription relationship: positively_regulates GO:0006390 ! mitochondrial transcription created_by: al creation_date: 2014-06-09T11:53:20Z [Term] id: GO:1903353 name: regulation of nucleus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282] synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie] synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006997 ! nucleus organization relationship: regulates GO:0006997 ! nucleus organization created_by: hjd creation_date: 2014-08-20T19:36:16Z [Term] id: GO:1903379 name: regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0060623 ! regulation of chromosome condensation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007076 ! mitotic chromosome condensation relationship: regulates GO:0007076 ! mitotic chromosome condensation created_by: al creation_date: 2014-08-26T13:57:13Z [Term] id: GO:1903380 name: positive regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation is_a: GO:1903379 ! regulation of mitotic chromosome condensation is_a: GO:1905821 ! positive regulation of chromosome condensation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007076 ! mitotic chromosome condensation relationship: positively_regulates GO:0007076 ! mitotic chromosome condensation created_by: al creation_date: 2014-08-26T13:57:29Z [Term] id: GO:1903416 name: response to glycoside namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus." [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970] synonym: "cellular response to ouabain" RELATED [CHEBI:472805] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: rl creation_date: 2014-09-05T12:41:01Z [Term] id: GO:1903429 name: regulation of cell maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048469 ! cell maturation relationship: regulates GO:0048469 ! cell maturation created_by: jl creation_date: 2014-09-15T13:31:23Z [Term] id: GO:1903430 name: negative regulation of cell maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie] synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie] synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048469 ! cell maturation relationship: negatively_regulates GO:0048469 ! cell maturation created_by: jl creation_date: 2014-09-15T13:31:32Z [Term] id: GO:1903431 name: positive regulation of cell maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "activation of cell maturation" NARROW [GOC:TermGenie] synonym: "activation of functional differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048469 ! cell maturation relationship: positively_regulates GO:0048469 ! cell maturation created_by: jl creation_date: 2014-09-15T13:31:41Z [Term] id: GO:1903453 name: RNA interference involved in olfactory learning namespace: biological_process def: "Any RNA interference that is involved in olfactory learning." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:23993094] synonym: "posttranscriptional gene silencing by siRNA involved in olfactory learning" EXACT [GOC:TermGenie] synonym: "RNAi involved in olfactory learning" EXACT [GOC:TermGenie] is_a: GO:0016246 ! RNA interference intersection_of: GO:0016246 ! RNA interference intersection_of: part_of GO:0008355 ! olfactory learning relationship: part_of GO:0008355 ! olfactory learning created_by: kmv creation_date: 2014-09-22T13:50:09Z [Term] id: GO:1903491 name: response to simvastatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23100282] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:0036273 ! response to statin created_by: hp creation_date: 2014-09-25T10:58:06Z [Term] id: GO:1903492 name: response to acetylsalicylate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] is_a: GO:0001101 ! response to acid chemical is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2014-09-25T10:58:23Z [Term] id: GO:1903493 name: response to clopidogrel namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2014-09-25T11:36:42Z [Term] id: GO:1903506 name: regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097659 ! nucleic acid-templated transcription relationship: regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:44:47Z [Term] id: GO:1903507 name: negative regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "down regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "down-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "downregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "inhibition of nucleic acid-templated transcription" NARROW [GOC:TermGenie] is_a: GO:1902679 ! negative regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: negatively_regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:44:56Z [Term] id: GO:1903508 name: positive regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "activation of nucleic acid-templated transcription" NARROW [GOC:TermGenie] synonym: "up regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "upregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] is_a: GO:1902680 ! positive regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: positively_regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:45:04Z [Term] id: GO:1903530 name: regulation of secretion by cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032940 ! secretion by cell relationship: regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:24:59Z [Term] id: GO:1903531 name: negative regulation of secretion by cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032940 ! secretion by cell relationship: negatively_regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:25:08Z [Term] id: GO:1903532 name: positive regulation of secretion by cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "activation of cellular secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion by cell" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032940 ! secretion by cell relationship: positively_regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:25:17Z [Term] id: GO:1903551 name: regulation of extracellular exosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071971 ! extracellular exosome assembly relationship: regulates GO:0071971 ! extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:25Z [Term] id: GO:1903552 name: negative regulation of extracellular exosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071971 ! extracellular exosome assembly relationship: negatively_regulates GO:0071971 ! extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:33Z [Term] id: GO:1903553 name: positive regulation of extracellular exosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles] synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071971 ! extracellular exosome assembly relationship: positively_regulates GO:0071971 ! extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:42Z [Term] id: GO:1903561 name: extracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] synonym: "microparticle" RELATED [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005576 ! extracellular region created_by: jl creation_date: 2014-10-22T14:26:11Z [Term] id: GO:1903564 name: regulation of protein localization to cilium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061512 ! protein localization to cilium relationship: regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:11Z [Term] id: GO:1903565 name: negative regulation of protein localization to cilium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061512 ! protein localization to cilium relationship: negatively_regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:20Z [Term] id: GO:1903566 name: positive regulation of protein localization to cilium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061512 ! protein localization to cilium relationship: positively_regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:28Z [Term] id: GO:1903578 name: regulation of ATP metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "regulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046034 ! ATP metabolic process relationship: regulates GO:0046034 ! ATP metabolic process created_by: sl creation_date: 2014-10-30T19:04:24Z [Term] id: GO:1903579 name: negative regulation of ATP metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "down regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ATP metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ATP metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046034 ! ATP metabolic process relationship: negatively_regulates GO:0046034 ! ATP metabolic process created_by: sl creation_date: 2014-10-30T19:04:33Z [Term] id: GO:1903580 name: positive regulation of ATP metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "activation of ATP metabolic process" NARROW [GOC:TermGenie] synonym: "activation of ATP metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046034 ! ATP metabolic process relationship: positively_regulates GO:0046034 ! ATP metabolic process created_by: sl creation_date: 2014-10-30T19:04:42Z [Term] id: GO:1903649 name: regulation of cytoplasmic transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016482 ! cytosolic transport relationship: regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T13:38:17Z [Term] id: GO:1903650 name: negative regulation of cytoplasmic transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "down regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "down regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "down-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "downregulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "inhibition of cytoplasmic transport" NARROW [GOC:TermGenie] synonym: "negative regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016482 ! cytosolic transport relationship: negatively_regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T13:38:26Z [Term] id: GO:1903651 name: positive regulation of cytoplasmic transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "activation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "activation of cytoplasmic transport" NARROW [GOC:TermGenie] synonym: "positive regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "up-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "upregulation of cytoplasmic transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016482 ! cytosolic transport relationship: positively_regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T13:38:34Z [Term] id: GO:1903653 name: modulation by symbiont of host cell motility namespace: biological_process def: "Modulation of host cell motility by a symbiont of that host." [GO_REF:0000063, GOC:TermGenie, PMID:25049409] synonym: "modulation by symbiont of host cell locomotion" EXACT [] synonym: "modulation by symbiont of host cell movement" RELATED [] synonym: "regulation by symbiont of host cell motility" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0048870 ! cell motility created_by: jl creation_date: 2014-11-24T17:37:56Z [Term] id: GO:1903664 name: regulation of asexual reproduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019954 ! asexual reproduction relationship: regulates GO:0019954 ! asexual reproduction created_by: pf creation_date: 2014-11-26T21:13:24Z [Term] id: GO:1903665 name: negative regulation of asexual reproduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] synonym: "down regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "down-regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "downregulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "inhibition of asexual reproduction" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1903664 ! regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019954 ! asexual reproduction relationship: negatively_regulates GO:0019954 ! asexual reproduction created_by: pf creation_date: 2014-11-26T21:13:32Z [Term] id: GO:1903666 name: positive regulation of asexual reproduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] synonym: "activation of asexual reproduction" NARROW [GOC:TermGenie] synonym: "up regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "up-regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "upregulation of asexual reproduction" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1903664 ! regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019954 ! asexual reproduction relationship: positively_regulates GO:0019954 ! asexual reproduction created_by: pf creation_date: 2014-11-26T21:13:40Z [Term] id: GO:1903706 name: regulation of hemopoiesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030097 ! hemopoiesis relationship: regulates GO:0030097 ! hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:13Z [Term] id: GO:1903707 name: negative regulation of hemopoiesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie] synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030097 ! hemopoiesis relationship: negatively_regulates GO:0030097 ! hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:21Z [Term] id: GO:1903708 name: positive regulation of hemopoiesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of blood cell formation" NARROW [GOC:TermGenie] synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie] synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030097 ! hemopoiesis relationship: positively_regulates GO:0030097 ! hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:30Z [Term] id: GO:1903792 name: negative regulation of anion transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "down regulation of anion transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anion transport" EXACT [GOC:TermGenie] synonym: "downregulation of anion transport" EXACT [GOC:TermGenie] synonym: "inhibition of anion transport" NARROW [GOC:TermGenie] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006820 ! anion transport relationship: negatively_regulates GO:0006820 ! anion transport created_by: sl creation_date: 2015-01-12T21:50:20Z [Term] id: GO:1903793 name: positive regulation of anion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "activation of anion transport" NARROW [GOC:TermGenie] synonym: "up regulation of anion transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anion transport" EXACT [GOC:TermGenie] synonym: "upregulation of anion transport" EXACT [GOC:TermGenie] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006820 ! anion transport relationship: positively_regulates GO:0006820 ! anion transport created_by: sl creation_date: 2015-01-12T21:50:30Z [Term] id: GO:1903825 name: organic acid transmembrane transport namespace: biological_process def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] is_a: GO:0015849 ! organic acid transport is_a: GO:0055085 ! transmembrane transport created_by: vw creation_date: 2015-01-20T10:20:58Z [Term] id: GO:1903827 name: regulation of cellular protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034613 ! cellular protein localization relationship: regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:14Z [Term] id: GO:1903828 name: negative regulation of cellular protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of channel localizer activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034613 ! cellular protein localization relationship: negatively_regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:24Z [Term] id: GO:1903829 name: positive regulation of cellular protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "activation of cellular protein localization" NARROW [GOC:TermGenie] synonym: "activation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034613 ! cellular protein localization relationship: positively_regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:33Z [Term] id: GO:1903959 name: regulation of anion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098656 ! anion transmembrane transport relationship: regulates GO:0098656 ! anion transmembrane transport created_by: pr creation_date: 2015-02-25T13:52:25Z [Term] id: GO:1903960 name: negative regulation of anion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of anion transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:0034766 ! negative regulation of ion transmembrane transport is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098656 ! anion transmembrane transport relationship: negatively_regulates GO:0098656 ! anion transmembrane transport created_by: pr creation_date: 2015-02-25T13:52:35Z [Term] id: GO:1903961 name: positive regulation of anion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of anion transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of anion transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0034767 ! positive regulation of ion transmembrane transport is_a: GO:1903793 ! positive regulation of anion transport is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098656 ! anion transmembrane transport relationship: positively_regulates GO:0098656 ! anion transmembrane transport created_by: pr creation_date: 2015-02-25T13:52:44Z [Term] id: GO:1903998 name: regulation of eating behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] synonym: "regulation of eating behaviour" EXACT [GOC:TermGenie] is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042755 ! eating behavior relationship: regulates GO:0042755 ! eating behavior created_by: sl creation_date: 2015-03-05T20:40:22Z [Term] id: GO:1903999 name: negative regulation of eating behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] synonym: "down regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "down regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "down-regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "down-regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "downregulation of eating behavior" EXACT [GOC:TermGenie] synonym: "downregulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "inhibition of eating behavior" NARROW [GOC:TermGenie] synonym: "inhibition of eating behaviour" NARROW [GOC:TermGenie] synonym: "negative regulation of eating behaviour" EXACT [GOC:TermGenie] is_a: GO:1903998 ! regulation of eating behavior is_a: GO:2000252 ! negative regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042755 ! eating behavior relationship: negatively_regulates GO:0042755 ! eating behavior created_by: sl creation_date: 2015-03-05T20:40:28Z [Term] id: GO:1904000 name: positive regulation of eating behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] synonym: "activation of eating behavior" NARROW [GOC:TermGenie] synonym: "activation of eating behaviour" NARROW [GOC:TermGenie] synonym: "positive regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "up regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "up regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "up-regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "up-regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "upregulation of eating behavior" EXACT [GOC:TermGenie] synonym: "upregulation of eating behaviour" EXACT [GOC:TermGenie] is_a: GO:1903998 ! regulation of eating behavior is_a: GO:2000253 ! positive regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042755 ! eating behavior relationship: positively_regulates GO:0042755 ! eating behavior created_by: sl creation_date: 2015-03-05T20:40:35Z [Term] id: GO:1904018 name: positive regulation of vasculature development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453] synonym: "activation of vascular system development" RELATED [GOC:TermGenie] synonym: "activation of vasculature development" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001944 ! vasculature development relationship: positively_regulates GO:0001944 ! vasculature development created_by: sl creation_date: 2015-03-06T22:17:04Z [Term] id: GO:1904057 name: negative regulation of sensory perception of pain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "down regulation of nociception" EXACT [GOC:TermGenie] synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "down-regulation of nociception" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "downregulation of nociception" EXACT [GOC:TermGenie] synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "inhibition of nociception" NARROW [GOC:TermGenie] synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "negative regulation of nociception" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019233 ! sensory perception of pain relationship: negatively_regulates GO:0019233 ! sensory perception of pain created_by: sl creation_date: 2015-03-18T20:33:57Z [Term] id: GO:1904058 name: positive regulation of sensory perception of pain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "activation of nociception" NARROW [GOC:TermGenie] synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "positive regulation of nociception" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of nociception" EXACT [GOC:TermGenie] synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "up-regulation of nociception" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "upregulation of nociception" EXACT [GOC:TermGenie] synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019233 ! sensory perception of pain relationship: positively_regulates GO:0019233 ! sensory perception of pain created_by: sl creation_date: 2015-03-18T20:34:03Z [Term] id: GO:1904059 name: regulation of locomotor rhythm namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] synonym: "regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045475 ! locomotor rhythm relationship: regulates GO:0045475 ! locomotor rhythm created_by: sl creation_date: 2015-03-18T20:38:52Z [Term] id: GO:1904060 name: negative regulation of locomotor rhythm namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] synonym: "down regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "down regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "down-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "down-regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "downregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "downregulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "inhibition of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "inhibition of locomotor rhythm" NARROW [GOC:TermGenie] synonym: "negative regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] is_a: GO:0042754 ! negative regulation of circadian rhythm is_a: GO:0048521 ! negative regulation of behavior is_a: GO:1904059 ! regulation of locomotor rhythm intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045475 ! locomotor rhythm relationship: negatively_regulates GO:0045475 ! locomotor rhythm created_by: sl creation_date: 2015-03-18T20:38:58Z [Term] id: GO:1904061 name: positive regulation of locomotor rhythm namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] synonym: "activation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "activation of locomotor rhythm" NARROW [GOC:TermGenie] synonym: "positive regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "up regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "up regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "up-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "up-regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "upregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "upregulation of locomotor rhythm" EXACT [GOC:TermGenie] is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0048520 ! positive regulation of behavior is_a: GO:1904059 ! regulation of locomotor rhythm intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045475 ! locomotor rhythm relationship: positively_regulates GO:0045475 ! locomotor rhythm created_by: sl creation_date: 2015-03-18T20:39:03Z [Term] id: GO:1904068 name: G protein-coupled receptor signaling pathway involved in social behavior namespace: biological_process def: "Any G protein-coupled receptor signaling pathway that is involved in social behavior." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789] synonym: "G protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in social behavior" EXACT [] synonym: "G-protein coupled receptor signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "GPCR signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "GPCR signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: part_of GO:0035176 ! social behavior relationship: part_of GO:0035176 ! social behavior created_by: kmv creation_date: 2015-03-20T01:51:10Z [Term] id: GO:1904081 name: positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:24353061] synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0030182 ! neuron differentiation relationship: part_of GO:0030182 ! neuron differentiation created_by: kmv creation_date: 2015-03-24T20:15:59Z [Term] id: GO:1904092 name: regulation of autophagic cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] synonym: "regulation of autophagic death" BROAD [GOC:TermGenie] synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie] synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie] is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048102 ! autophagic cell death relationship: regulates GO:0048102 ! autophagic cell death created_by: bhm creation_date: 2015-03-26T16:41:32Z [Term] id: GO:1904093 name: negative regulation of autophagic cell death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] synonym: "down regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "down regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "down-regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "down-regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "downregulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "downregulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "inhibition of autophagic cell death" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] synonym: "inhibition of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "negative regulation of type II programmed cell death" RELATED [GOC:TermGenie] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:1904092 ! regulation of autophagic cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048102 ! autophagic cell death relationship: negatively_regulates GO:0048102 ! autophagic cell death created_by: bhm creation_date: 2015-03-26T16:41:39Z [Term] id: GO:1904094 name: positive regulation of autophagic cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] synonym: "activation of autophagic cell death" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] synonym: "activation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "positive regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "up regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "up regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "up-regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "upregulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "upregulation of type II programmed cell death" RELATED [GOC:TermGenie] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:1904092 ! regulation of autophagic cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048102 ! autophagic cell death relationship: positively_regulates GO:0048102 ! autophagic cell death created_by: bhm creation_date: 2015-03-26T16:41:45Z [Term] id: GO:1904170 name: regulation of bleb assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032060 ! bleb assembly relationship: regulates GO:0032060 ! bleb assembly created_by: als creation_date: 2015-04-23T09:32:19Z [Term] id: GO:1904171 name: negative regulation of bleb assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie] synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032060 ! bleb assembly relationship: negatively_regulates GO:0032060 ! bleb assembly created_by: als creation_date: 2015-04-23T09:32:25Z [Term] id: GO:1904172 name: positive regulation of bleb assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "activation of bleb assembly" NARROW [GOC:TermGenie] synonym: "activation of cell blebbing" NARROW [GOC:TermGenie] synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032060 ! bleb assembly relationship: positively_regulates GO:0032060 ! bleb assembly created_by: als creation_date: 2015-04-23T09:32:31Z [Term] id: GO:1904409 name: regulation of secretory granule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033363 ! secretory granule organization relationship: regulates GO:0033363 ! secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:42Z [Term] id: GO:1904410 name: negative regulation of secretory granule organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033363 ! secretory granule organization relationship: negatively_regulates GO:0033363 ! secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:49Z [Term] id: GO:1904411 name: positive regulation of secretory granule organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033363 ! secretory granule organization relationship: positively_regulates GO:0033363 ! secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:55Z [Term] id: GO:1904631 name: response to glucoside namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873] synonym: "response to glucosides" EXACT [] is_a: GO:1903416 ! response to glycoside created_by: sl creation_date: 2015-08-28T14:01:31Z [Term] id: GO:1904660 name: regulation of sensory perception of bitter taste namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "regulation of bitter taste perception" EXACT [GOC:TermGenie] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050913 ! sensory perception of bitter taste relationship: regulates GO:0050913 ! sensory perception of bitter taste created_by: mr creation_date: 2015-09-04T17:54:10Z [Term] id: GO:1904661 name: negative regulation of sensory perception of bitter taste namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "down regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "down regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "down-regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "downregulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "downregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "inhibition of bitter taste perception" NARROW [GOC:TermGenie] synonym: "inhibition of sensory perception of bitter taste" NARROW [GOC:TermGenie] synonym: "negative regulation of bitter taste perception" EXACT [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:1904660 ! regulation of sensory perception of bitter taste intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050913 ! sensory perception of bitter taste relationship: negatively_regulates GO:0050913 ! sensory perception of bitter taste created_by: mr creation_date: 2015-09-04T17:54:17Z [Term] id: GO:1904662 name: positive regulation of sensory perception of bitter taste namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "activation of bitter taste perception" NARROW [GOC:TermGenie] synonym: "activation of sensory perception of bitter taste" NARROW [GOC:TermGenie] synonym: "positive regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "up regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "up regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "up-regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "upregulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "upregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:1904660 ! regulation of sensory perception of bitter taste intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050913 ! sensory perception of bitter taste relationship: positively_regulates GO:0050913 ! sensory perception of bitter taste created_by: mr creation_date: 2015-09-04T17:54:22Z [Term] id: GO:1904675 name: regulation of somatic stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:2000035 ! regulation of stem cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048103 ! somatic stem cell division relationship: regulates GO:0048103 ! somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:22Z [Term] id: GO:1904676 name: negative regulation of somatic stem cell division namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051782 ! negative regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048103 ! somatic stem cell division relationship: negatively_regulates GO:0048103 ! somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:28Z [Term] id: GO:1904677 name: positive regulation of somatic stem cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051781 ! positive regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048103 ! somatic stem cell division relationship: positively_regulates GO:0048103 ! somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:34Z [Term] id: GO:1904745 name: Atg1/ULK1 kinase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988] synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: dph creation_date: 2015-10-19T12:33:08Z [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902742 ! apoptotic process involved in development relationship: negatively_regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T14:12:27Z [Term] id: GO:1904747 name: positive regulation of apoptotic process involved in development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902742 ! apoptotic process involved in development relationship: positively_regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T14:12:34Z [Term] id: GO:1904748 name: regulation of apoptotic process involved in development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: Q10943 in PMID:22801495, inferred from mutant phenotype synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902742 ! apoptotic process involved in development relationship: regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T15:02:28Z [Term] id: GO:1904950 name: negative regulation of establishment of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045184 ! establishment of protein localization relationship: negatively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:24Z [Term] id: GO:1904951 name: positive regulation of establishment of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "activation of protein positioning" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045184 ! establishment of protein localization relationship: positively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:32Z [Term] id: GO:1905037 name: autophagosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie] synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie] is_a: GO:0007033 ! vacuole organization relationship: part_of GO:0016236 ! macroautophagy created_by: bf creation_date: 2016-03-08T14:18:10Z [Term] id: GO:1905039 name: carboxylic acid transmembrane transport namespace: biological_process def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1903825 ! organic acid transmembrane transport created_by: vw creation_date: 2016-03-09T15:33:53Z [Term] id: GO:1905119 name: response to haloperidol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901654 ! response to ketone created_by: dw creation_date: 2016-04-08T12:36:39Z [Term] id: GO:1905153 name: regulation of membrane invagination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010324 ! membrane invagination relationship: regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:43:54Z [Term] id: GO:1905154 name: negative regulation of membrane invagination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010324 ! membrane invagination relationship: negatively_regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:44:04Z [Term] id: GO:1905155 name: positive regulation of membrane invagination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of membrane invagination" NARROW [GOC:TermGenie] synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010324 ! membrane invagination relationship: positively_regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:44:12Z [Term] id: GO:1905213 name: negative regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725] is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:1902340 ! negative regulation of chromosome condensation is_a: GO:1903379 ! regulation of mitotic chromosome condensation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007076 ! mitotic chromosome condensation relationship: negatively_regulates GO:0007076 ! mitotic chromosome condensation created_by: vw creation_date: 2016-06-03T08:41:08Z [Term] id: GO:1905349 name: ciliary transition zone assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032] synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilial transition zone formation" EXACT [GOC:TermGenie] synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie] synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilium transition zone formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0060271 ! cilium assembly created_by: pr creation_date: 2016-08-04T14:49:43Z [Term] id: GO:1905419 name: sperm flagellum movement involved in flagellated sperm motility namespace: biological_process alt_id: GO:0097724 def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031] synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc] synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie] is_a: GO:0022414 ! reproductive process is_a: GO:0060294 ! cilium movement involved in cell motility intersection_of: GO:0003341 ! cilium movement intersection_of: part_of GO:0030317 ! flagellated sperm motility relationship: part_of GO:0030317 ! flagellated sperm motility created_by: krc creation_date: 2016-09-01T17:52:39Z [Term] id: GO:1905427 name: intracellular signal transduction involved in positive regulation of cell growth namespace: biological_process def: "Any intracellular signal transduction that is involved in positive regulation of cell growth." [GO_REF:0000060, GOC:al, GOC:TermGenie, GOC:vw, PMID:15917811] synonym: "intracellular protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in up regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in up-regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in upregulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling chain involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling chain involved in positive regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling chain involved in up regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in up-regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in upregulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling pathway involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] is_a: GO:0035556 ! intracellular signal transduction intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0030307 ! positive regulation of cell growth relationship: part_of GO:0030307 ! positive regulation of cell growth created_by: dph creation_date: 2016-09-07T18:15:01Z [Term] id: GO:1905516 name: positive regulation of fertilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576] synonym: "activation of fertilization" NARROW [GOC:TermGenie] synonym: "activation of syngamy" NARROW [GOC:TermGenie] synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie] synonym: "upregulation of fertilization" EXACT [GOC:TermGenie] synonym: "upregulation of syngamy" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009566 ! fertilization relationship: positively_regulates GO:0009566 ! fertilization created_by: pr creation_date: 2016-09-30T14:32:32Z [Term] id: GO:1905642 name: negative regulation of DNA methylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847] synonym: "down regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "inhibition of DNA methylation" NARROW [GOC:TermGenie] is_a: GO:0044030 ! regulation of DNA methylation is_a: GO:0051053 ! negative regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006306 ! DNA methylation relationship: negatively_regulates GO:0006306 ! DNA methylation created_by: bc creation_date: 2016-11-04T16:43:13Z [Term] id: GO:1905643 name: positive regulation of DNA methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847] synonym: "activation of DNA methylation" NARROW [GOC:TermGenie] synonym: "up regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA methylation" EXACT [GOC:TermGenie] is_a: GO:0044030 ! regulation of DNA methylation is_a: GO:0051054 ! positive regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006306 ! DNA methylation relationship: positively_regulates GO:0006306 ! DNA methylation created_by: bc creation_date: 2016-11-04T16:43:22Z [Term] id: GO:1905821 name: positive regulation of chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547] synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030261 ! chromosome condensation relationship: positively_regulates GO:0030261 ! chromosome condensation created_by: bmeldal creation_date: 2017-01-13T14:13:44Z [Term] id: GO:1905831 name: negative regulation of spindle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "down regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "down regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "down regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "downregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "downregulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of spindle formation" EXACT [GOC:TermGenie] synonym: "inhibition of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of bipolar spindle formation" NARROW [GOC:TermGenie] synonym: "inhibition of spindle assembly" NARROW [GOC:TermGenie] synonym: "inhibition of spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of spindle formation" NARROW [GOC:TermGenie] synonym: "negative regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle formation" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0090169 ! regulation of spindle assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051225 ! spindle assembly relationship: negatively_regulates GO:0051225 ! spindle assembly created_by: hbye creation_date: 2017-01-17T10:26:37Z [Term] id: GO:1905832 name: positive regulation of spindle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "activation of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of bipolar spindle formation" NARROW [GOC:TermGenie] synonym: "activation of spindle assembly" NARROW [GOC:TermGenie] synonym: "activation of spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of spindle formation" NARROW [GOC:TermGenie] synonym: "positive regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "up regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "up regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "up regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "upregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "upregulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of spindle formation" EXACT [GOC:TermGenie] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:0090169 ! regulation of spindle assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051225 ! spindle assembly relationship: positively_regulates GO:0051225 ! spindle assembly created_by: hbye creation_date: 2017-01-17T10:26:46Z [Term] id: GO:1905843 name: regulation of cellular response to gamma radiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] synonym: "regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:2001228 ! regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071480 ! cellular response to gamma radiation relationship: regulates GO:0071480 ! cellular response to gamma radiation created_by: rozaru creation_date: 2017-01-19T10:24:39Z [Term] id: GO:1905844 name: negative regulation of cellular response to gamma radiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] synonym: "down regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "down regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "inhibition of cellular response to gamma radiation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "inhibition of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "negative regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "negative regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1905843 ! regulation of cellular response to gamma radiation is_a: GO:2001229 ! negative regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071480 ! cellular response to gamma radiation relationship: negatively_regulates GO:0071480 ! cellular response to gamma radiation created_by: rozaru creation_date: 2017-01-19T10:24:48Z [Term] id: GO:1905845 name: positive regulation of cellular response to gamma radiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] synonym: "activation of cellular response to gamma radiation" NARROW [GOC:TermGenie] synonym: "activation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "activation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "positive regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "positive regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "up regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "up regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "upregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "upregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1905843 ! regulation of cellular response to gamma radiation is_a: GO:2001230 ! positive regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071480 ! cellular response to gamma radiation relationship: positively_regulates GO:0071480 ! cellular response to gamma radiation created_by: rozaru creation_date: 2017-01-19T10:24:57Z [Term] id: GO:1905864 name: regulation of Atg1/ULK1 kinase complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] synonym: "regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly relationship: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly created_by: paolaroncaglia creation_date: 2017-01-26T13:23:26Z [Term] id: GO:1905865 name: negative regulation of Atg1/ULK1 kinase complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] synonym: "down regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "inhibition of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of Atg1p signalling complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly relationship: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly created_by: paolaroncaglia creation_date: 2017-01-26T13:23:35Z [Term] id: GO:1905866 name: positive regulation of Atg1/ULK1 kinase complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] synonym: "activation of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "activation of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "activation of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] synonym: "activation of Atg1p signalling complex formation" NARROW [GOC:TermGenie] synonym: "activation of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly relationship: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly created_by: paolaroncaglia creation_date: 2017-01-26T13:23:44Z [Term] id: GO:1905879 name: regulation of oogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048477 ! oogenesis relationship: regulates GO:0048477 ! oogenesis created_by: hbye creation_date: 2017-01-31T09:31:05Z [Term] id: GO:1905880 name: negative regulation of oogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of ovum development" EXACT [GOC:TermGenie] synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of ovum development" EXACT [GOC:TermGenie] synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of ovum development" NARROW [GOC:TermGenie] synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048477 ! oogenesis relationship: negatively_regulates GO:0048477 ! oogenesis created_by: hbye creation_date: 2017-01-31T09:31:15Z [Term] id: GO:1905881 name: positive regulation of oogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "activation of oogenesis" NARROW [GOC:TermGenie] synonym: "activation of ovum development" NARROW [GOC:TermGenie] synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048477 ! oogenesis relationship: positively_regulates GO:0048477 ! oogenesis created_by: hbye creation_date: 2017-01-31T09:31:23Z [Term] id: GO:1990054 name: response to temozolomide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2013-02-22T10:09:44Z [Term] id: GO:1990110 name: callus formation namespace: biological_process def: "The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate." [ISBN:0070187517] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0042060 ! wound healing created_by: tb creation_date: 2013-05-29T22:02:52Z [Term] id: GO:1990215 name: negative regulation by symbiont of host intracellular transport namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22319451] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0052038 ! modulation by symbiont of host intracellular transport intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: negatively_regulates GO:0046907 ! intracellular transport created_by: ml creation_date: 2013-10-10T15:42:22Z [Term] id: GO:1990603 name: dark adaptation namespace: biological_process def: "The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light." [GOC:hjd, http://www.ncbi.nlm.nih.gov/books/NBK11525/, ISBN:0198506732] comment: The proteins RGS9-1 and Gb5L localize to the rod inner segment during dark adaptation, but to the rod outer segment during light adaptation. PMID:23555598 is_a: GO:0071485 ! cellular response to absence of light created_by: hjd creation_date: 2015-01-09T20:35:46Z [Term] id: GO:1990708 name: conditioned place preference namespace: biological_process def: "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug." [PMID:21549821] is_a: GO:0008306 ! associative learning created_by: sl creation_date: 2015-03-18T20:28:59Z [Term] id: GO:1990904 name: ribonucleoprotein complex namespace: cellular_component alt_id: GO:0030529 alt_id: GO:1990903 def: "A macromolecular complex containing both protein and RNA molecules." [GOC:vesicles] subset: goslim_pir synonym: "extracellular ribonucleoprotein complex" NARROW [] synonym: "intracellular ribonucleoprotein complex" NARROW [] synonym: "protein-RNA complex" EXACT [] synonym: "ribonucleoprotein complex" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex created_by: pr creation_date: 2015-11-19T12:26:37Z [Term] id: GO:2000026 name: regulation of multicellular organismal development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007275 ! multicellular organism development relationship: regulates GO:0007275 ! multicellular organism development created_by: tanyaberardini creation_date: 2010-08-05T11:25:59Z [Term] id: GO:2000027 name: regulation of animal organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009887 ! animal organ morphogenesis relationship: regulates GO:0009887 ! animal organ morphogenesis created_by: tanyaberardini creation_date: 2010-08-05T11:26:27Z [Term] id: GO:2000030 name: regulation of response to red or far red light namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to red or far red light." [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009639 ! response to red or far red light relationship: regulates GO:0009639 ! response to red or far red light created_by: tanyaberardini creation_date: 2010-08-05T11:30:10Z [Term] id: GO:2000035 name: regulation of stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] synonym: "regulation of stem cell renewal" EXACT [GOC:obol] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017145 ! stem cell division relationship: regulates GO:0017145 ! stem cell division created_by: tanyaberardini creation_date: 2010-08-05T11:34:53Z [Term] id: GO:2000070 name: regulation of response to water deprivation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol] synonym: "regulation of drought tolerance" RELATED [GOC:obol] synonym: "regulation of response to dehydration" EXACT [GOC:obol] synonym: "regulation of response to drought" EXACT [GOC:obol] synonym: "regulation of response to thirst" EXACT [GOC:obol] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009414 ! response to water deprivation relationship: regulates GO:0009414 ! response to water deprivation created_by: tanyaberardini creation_date: 2010-08-23T11:32:32Z [Term] id: GO:2000112 name: regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: regulates GO:0034645 ! cellular macromolecule biosynthetic process created_by: tanyaberardini creation_date: 2010-09-15T08:55:45Z [Term] id: GO:2000113 name: negative regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process created_by: tanyaberardini creation_date: 2010-09-15T08:55:48Z [Term] id: GO:2000145 name: regulation of cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] synonym: "regulation of cell locomotion" EXACT [GOC:obol] synonym: "regulation of cell movement" RELATED [GOC:obol] synonym: "regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048870 ! cell motility relationship: regulates GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-01T09:41:21Z [Term] id: GO:2000146 name: negative regulation of cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] synonym: "negative regulation of cell movement" RELATED [GOC:obol] synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048870 ! cell motility relationship: negatively_regulates GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-01T09:41:26Z [Term] id: GO:2000147 name: positive regulation of cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] synonym: "positive regulation of cell movement" RELATED [GOC:obol] synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048870 ! cell motility relationship: positively_regulates GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-01T09:41:30Z [Term] id: GO:2000155 name: positive regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl] synonym: "positive regulation of ciliary cell motility" RELATED [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060285 ! cilium-dependent cell motility relationship: positively_regulates GO:0060285 ! cilium-dependent cell motility created_by: midori creation_date: 2010-10-04T12:41:05Z [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048514 ! blood vessel morphogenesis relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis created_by: dph creation_date: 2010-10-13T12:46:31Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022414 ! reproductive process relationship: regulates GO:0022414 ! reproductive process created_by: midori creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022414 ! reproductive process relationship: negatively_regulates GO:0022414 ! reproductive process created_by: midori creation_date: 2010-11-10T02:44:05Z [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022414 ! reproductive process relationship: positively_regulates GO:0022414 ! reproductive process created_by: midori creation_date: 2010-11-10T02:44:08Z [Term] id: GO:2000252 name: negative regulation of feeding behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "negative regulation of behavioral response to food" EXACT [GOC:obol] synonym: "negative regulation of behavioural response to food" EXACT [GOC:obol] synonym: "negative regulation of drinking" RELATED [GOC:obol] synonym: "negative regulation of eating" RELATED [GOC:obol] synonym: "negative regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007631 ! feeding behavior relationship: negatively_regulates GO:0007631 ! feeding behavior created_by: yaf creation_date: 2010-11-18T11:24:14Z [Term] id: GO:2000253 name: positive regulation of feeding behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "positive regulation of behavioral response to food" EXACT [GOC:obol] synonym: "positive regulation of behavioural response to food" EXACT [GOC:obol] synonym: "positive regulation of drinking" RELATED [GOC:obol] synonym: "positive regulation of eating" RELATED [GOC:obol] synonym: "positive regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007631 ! feeding behavior relationship: positively_regulates GO:0007631 ! feeding behavior created_by: yaf creation_date: 2010-11-18T11:24:18Z [Term] id: GO:2000272 name: negative regulation of signaling receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol] synonym: "negative regulation of receptor activity" BROAD [] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0044092 ! negative regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038023 ! signaling receptor activity relationship: negatively_regulates GO:0038023 ! signaling receptor activity created_by: rfoulger creation_date: 2010-12-02T09:28:47Z [Term] id: GO:2000273 name: positive regulation of signaling receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling receptor activity." [GOC:obol] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0044093 ! positive regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038023 ! signaling receptor activity relationship: positively_regulates GO:0038023 ! signaling receptor activity created_by: rfoulger creation_date: 2010-12-02T09:28:50Z [Term] id: GO:2000683 name: regulation of cellular response to X-ray namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071481 ! cellular response to X-ray relationship: regulates GO:0071481 ! cellular response to X-ray created_by: yaf creation_date: 2011-05-10T01:40:41Z [Term] id: GO:2000684 name: negative regulation of cellular response to X-ray namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "negative regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000683 ! regulation of cellular response to X-ray intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071481 ! cellular response to X-ray relationship: negatively_regulates GO:0071481 ! cellular response to X-ray created_by: yaf creation_date: 2011-05-10T01:40:45Z [Term] id: GO:2000685 name: positive regulation of cellular response to X-ray namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "positive regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000683 ! regulation of cellular response to X-ray intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071481 ! cellular response to X-ray relationship: positively_regulates GO:0071481 ! cellular response to X-ray created_by: yaf creation_date: 2011-05-10T01:40:49Z [Term] id: GO:2000785 name: regulation of autophagosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF] synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol] synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol] synonym: "regulation of autophagosome formation" EXACT [GOC:obol] synonym: "regulation of PAS formation" RELATED [GOC:obol] is_a: GO:0016241 ! regulation of macroautophagy is_a: GO:0044088 ! regulation of vacuole organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000045 ! autophagosome assembly relationship: regulates GO:0000045 ! autophagosome assembly created_by: rl creation_date: 2011-06-24T11:19:08Z [Term] id: GO:2000786 name: positive regulation of autophagosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF] synonym: "positive regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "positive regulation of autophagic vacuole formation" RELATED [GOC:obol] synonym: "positive regulation of autophagosome biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of autophagosome formation" EXACT [GOC:obol] synonym: "positive regulation of PAS formation" RELATED [GOC:obol] is_a: GO:0016239 ! positive regulation of macroautophagy is_a: GO:0044090 ! positive regulation of vacuole organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:2000785 ! regulation of autophagosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000045 ! autophagosome assembly relationship: positively_regulates GO:0000045 ! autophagosome assembly created_by: rl creation_date: 2011-06-24T11:19:12Z [Term] id: GO:2001020 name: regulation of response to DNA damage stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] synonym: "regulation of cellular DNA damage response" EXACT [GOC:obol] synonym: "regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "regulation of DNA damage response" EXACT [GOC:obol] synonym: "regulation of response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006974 ! cellular response to DNA damage stimulus relationship: regulates GO:0006974 ! cellular response to DNA damage stimulus created_by: yaf creation_date: 2011-08-19T10:20:25Z [Term] id: GO:2001021 name: negative regulation of response to DNA damage stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] synonym: "negative regulation of cellular DNA damage response" EXACT [GOC:obol] synonym: "negative regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "negative regulation of DNA damage response" EXACT [GOC:obol] synonym: "negative regulation of response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006974 ! cellular response to DNA damage stimulus relationship: negatively_regulates GO:0006974 ! cellular response to DNA damage stimulus created_by: yaf creation_date: 2011-08-19T10:20:29Z [Term] id: GO:2001022 name: positive regulation of response to DNA damage stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] synonym: "positive regulation of cellular DNA damage response" EXACT [GOC:obol] synonym: "positive regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "positive regulation of DNA damage response" EXACT [GOC:obol] synonym: "positive regulation of response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006974 ! cellular response to DNA damage stimulus relationship: positively_regulates GO:0006974 ! cellular response to DNA damage stimulus created_by: yaf creation_date: 2011-08-19T10:20:33Z [Term] id: GO:2001023 name: regulation of response to drug namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol] synonym: "regulation of drug resistance" RELATED [GOC:obol] synonym: "regulation of drug susceptibility/resistance" RELATED [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042493 ! response to drug relationship: regulates GO:0042493 ! response to drug created_by: yaf creation_date: 2011-08-19T01:47:20Z [Term] id: GO:2001024 name: negative regulation of response to drug namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to drug." [GOC:obol] synonym: "negative regulation of drug resistance" RELATED [GOC:obol] synonym: "negative regulation of drug susceptibility/resistance" RELATED [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042493 ! response to drug relationship: negatively_regulates GO:0042493 ! response to drug created_by: yaf creation_date: 2011-08-19T01:47:24Z [Term] id: GO:2001025 name: positive regulation of response to drug namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to drug." [GOC:obol] synonym: "positive regulation of drug resistance" RELATED [GOC:obol] synonym: "positive regulation of drug susceptibility/resistance" RELATED [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042493 ! response to drug relationship: positively_regulates GO:0042493 ! response to drug created_by: yaf creation_date: 2011-08-19T01:47:27Z [Term] id: GO:2001141 name: regulation of RNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032774 ! RNA biosynthetic process relationship: regulates GO:0032774 ! RNA biosynthetic process created_by: dph creation_date: 2011-10-17T11:36:25Z [Term] id: GO:2001169 name: regulation of ATP biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "regulation of ATP anabolism" EXACT [GOC:obol] synonym: "regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "regulation of ATP formation" EXACT [GOC:obol] synonym: "regulation of ATP regeneration" RELATED [GOC:obol] synonym: "regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006754 ! ATP biosynthetic process relationship: regulates GO:0006754 ! ATP biosynthetic process created_by: kmv creation_date: 2011-10-26T03:18:03Z [Term] id: GO:2001170 name: negative regulation of ATP biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "negative regulation of ATP anabolism" EXACT [GOC:obol] synonym: "negative regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of ATP formation" EXACT [GOC:obol] synonym: "negative regulation of ATP regeneration" RELATED [GOC:obol] synonym: "negative regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process is_a: GO:1903579 ! negative regulation of ATP metabolic process is_a: GO:2001169 ! regulation of ATP biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006754 ! ATP biosynthetic process relationship: negatively_regulates GO:0006754 ! ATP biosynthetic process created_by: kmv creation_date: 2011-10-26T03:18:13Z [Term] id: GO:2001171 name: positive regulation of ATP biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "positive regulation of ATP anabolism" EXACT [GOC:obol] synonym: "positive regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of ATP formation" EXACT [GOC:obol] synonym: "positive regulation of ATP regeneration" RELATED [GOC:obol] synonym: "positive regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process is_a: GO:1903580 ! positive regulation of ATP metabolic process is_a: GO:2001169 ! regulation of ATP biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006754 ! ATP biosynthetic process relationship: positively_regulates GO:0006754 ! ATP biosynthetic process created_by: kmv creation_date: 2011-10-26T03:18:26Z [Term] id: GO:2001228 name: regulation of response to gamma radiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to gamma radiation." [GOC:obol] synonym: "regulation of response to gamma ray" RELATED [GOC:obol] synonym: "regulation of response to gamma-ray photon" RELATED [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010332 ! response to gamma radiation relationship: regulates GO:0010332 ! response to gamma radiation created_by: yaf creation_date: 2011-11-20T04:51:07Z [Term] id: GO:2001229 name: negative regulation of response to gamma radiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol] synonym: "negative regulation of response to gamma ray" RELATED [GOC:obol] synonym: "negative regulation of response to gamma-ray photon" RELATED [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2001228 ! regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010332 ! response to gamma radiation relationship: negatively_regulates GO:0010332 ! response to gamma radiation created_by: yaf creation_date: 2011-11-20T04:51:14Z [Term] id: GO:2001230 name: positive regulation of response to gamma radiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to gamma radiation." [GOC:obol] synonym: "positive regulation of response to gamma ray" RELATED [GOC:obol] synonym: "positive regulation of response to gamma-ray photon" RELATED [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2001228 ! regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010332 ! response to gamma radiation relationship: positively_regulates GO:0010332 ! response to gamma radiation created_by: yaf creation_date: 2011-11-20T04:51:17Z [Term] id: GO:2001233 name: regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097190 ! apoptotic signaling pathway relationship: regulates GO:0097190 ! apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:20:49Z [Term] id: GO:2001234 name: negative regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097190 ! apoptotic signaling pathway relationship: negatively_regulates GO:0097190 ! apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:20:54Z [Term] id: GO:2001235 name: positive regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097190 ! apoptotic signaling pathway relationship: positively_regulates GO:0097190 ! apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:20:58Z [Term] id: GO:2001251 name: negative regulation of chromosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol] synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051276 ! chromosome organization relationship: negatively_regulates GO:0051276 ! chromosome organization created_by: yaf creation_date: 2011-12-02T02:01:20Z [Term] id: GO:2001252 name: positive regulation of chromosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol] synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051276 ! chromosome organization relationship: positively_regulates GO:0051276 ! chromosome organization created_by: yaf creation_date: 2011-12-02T02:01:26Z [Term] id: OGMS:0000031 name: disease def: "A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism." [] is_a: BFO:0000016 ! disposition [Term] id: ObsoleteClass name: Obsolete Class [Term] id: PATO:0000001 name: quality namespace: quality alt_id: PATO:0000072 def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG] is_a: BFO:0000020 ! specifically dependent continuant property_value: IAO:0000589 "quality (PATO)" xsd:string [Term] id: PATO:0000004 name: mobility namespace: quality def: "A quality of inhering in a bearer by virtue of the bearer's disposition to move freely." [PATOC:GVG] comment: Should be defined using translocation. subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0000014 name: color namespace: quality alt_id: PATO:0000020 def: "A composite chromatic quality composed of hue, saturation and intensity parts." [PATOC:GVG] subset: attribute_slim synonym: "colour" EXACT [] synonym: "relative color" EXACT [] is_a: PATO:0000051 ! morphology is_a: PATO:0001300 ! optical quality [Term] id: PATO:0000025 name: composition namespace: quality alt_id: PATO:0002015 def: "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." [PATOC:GVG] comment: For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood). subset: attribute_slim subset: scalar_slim synonym: "composed of" EXACT [] synonym: "compositionality" EXACT [] synonym: "content" EXACT [] synonym: "structure, composition" EXACT [] is_a: PATO:0000141 ! structure [Term] id: PATO:0000033 name: concentration of namespace: quality def: "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." [Wikipedia:http\://en.wikipedia.org/wiki/concentration] subset: attribute_slim subset: relational_slim subset: scalar_slim synonym: "concentration" EXACT [] is_a: PATO:0002182 ! molecular quality [Term] id: PATO:0000040 name: distance namespace: quality def: "A quality that is the extent of space between two entities." [PATOC:GVG] subset: attribute_slim subset: relational_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0000047 name: biological sex namespace: quality def: "An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved." [MGED:MGED] subset: attribute_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000051 name: morphology namespace: quality def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG] subset: attribute_slim is_a: BFO:0000019 ! quality is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0000052 name: shape namespace: quality alt_id: PATO:0001647 def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG] comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. subset: attribute_slim synonym: "relational shape quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000068 name: qualitative namespace: quality comment: TODO: define this or obsolete it and move children somewhere else. is_a: PATO:0000001 ! quality [Term] id: PATO:0000069 name: deviation (from_normal) namespace: quality def: "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000070 name: amount namespace: quality alt_id: PATO:0000053 alt_id: PATO:0000071 alt_id: PATO:0001169 alt_id: PATO:0001226 def: "The number of entities of this type that are part of the whole organism." [PATOC:GVG] comment: This term was originally named "presence". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10. subset: attribute_slim synonym: "count in organism" RELATED [] synonym: "number" RELATED [] synonym: "presence" RELATED [] synonym: "presence or absence in organism" EXACT [] synonym: "quantitative" EXACT [] is_a: PATO:0000068 ! qualitative relationship: reciprocal_of PATO:0001555 ! has number of [Term] id: PATO:0000117 name: size namespace: quality def: "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." [WordNet:WordNet] subset: attribute_slim subset: scalar_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000122 name: length namespace: quality def: "A 1-D extent quality which is equal to the distance between two points." [PATOC:GVG] subset: attribute_slim subset: mpath_slim subset: scalar_slim is_a: PATO:0001708 ! 1-D extent [Term] id: PATO:0000125 name: mass namespace: quality def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG] subset: attribute_slim subset: relational_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0000128 name: weight namespace: quality def: "A physical quality inhering in a bearer that has mass near a gravitational body." [Wikipedia:http\://en.wikipedia.org/wiki/Weight] subset: attribute_slim subset: scalar_slim is_a: PATO:0001035 ! force [Term] id: PATO:0000133 name: orientation namespace: quality alt_id: PATO:0000137 def: "A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object." [PATOC:JE] subset: attribute_slim subset: relational_slim synonym: "amount of rotation" RELATED [] synonym: "angle" RELATED [] synonym: "angular magnitude" RELATED [] synonym: "angular placement" EXACT [] synonym: "plane angle" RELATED [] is_a: PATO:0000140 ! position [Term] id: PATO:0000140 name: position namespace: quality alt_id: PATO:0001032 alt_id: PATO:0001631 def: "A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity." [PATOC:GVG] subset: attribute_slim synonym: "location" EXACT [] synonym: "placement" EXACT [] synonym: "relational spatial quality" EXACT [] is_a: PATO:0001018 ! physical quality [Term] id: PATO:0000141 name: structure namespace: quality alt_id: PATO:0001452 def: "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." [PATOC:GVG] subset: attribute_slim synonym: "conformation" BROAD [VT:1000738] synonym: "relational structural quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000161 name: rate namespace: quality def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time." [PATOC:melissa] subset: attribute_slim subset: scalar_slim is_a: PATO:0002062 ! physical quality of a process [Term] id: PATO:0000169 name: viability namespace: quality def: "An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000299 name: mobile namespace: quality def: "A mobility quality of inhering in a bearer by virtue of the bearer's disposition to move freely." [PATOC:GVG] subset: disposition_slim subset: value_slim is_a: PATO:0000004 ! mobility disjoint_from: PATO:0000300 ! immobile relationship: is_opposite_of PATO:0000300 ! immobile [Term] id: PATO:0000300 name: immobile namespace: quality def: "A mobility quality inhering in a bearer by virtue of the bearer's being incapable to move freely." [PATOC:GVG] subset: disposition_slim subset: value_slim synonym: "fixed" RELATED [] is_a: PATO:0000004 ! mobility relationship: is_opposite_of PATO:0000299 ! mobile [Term] id: PATO:0000374 name: increased distance namespace: quality def: "A distance which is greater relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "long distance" RELATED [] is_a: PATO:0000040 ! distance is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000040 ! distance intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000375 ! decreased distance [Term] id: PATO:0000375 name: decreased distance namespace: quality def: "A distance which is lesser relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "short distance" RELATED [] is_a: PATO:0000040 ! distance is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000040 ! distance intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000374 ! increased distance [Term] id: PATO:0000383 name: female namespace: quality def: "A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes." [MGED:MGED] subset: mpath_slim subset: value_slim is_a: PATO:0001894 ! phenotypic sex [Term] id: PATO:0000384 name: male namespace: quality def: "A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes." [MGED:MGED] subset: mpath_slim subset: value_slim is_a: PATO:0001894 ! phenotypic sex [Term] id: PATO:0000405 name: curled namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having parallel chains in undulate fashion on the border." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0000406 name: curved namespace: quality def: "A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend." [WordNet:WordNet] subset: cell_quality subset: value_slim synonym: "bowing" NARROW [] synonym: "curled" RELATED [] is_a: PATO:0001591 ! curvature [Term] id: PATO:0000411 name: circular namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." [thefreedictionary.com:thefreedictionary.com] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "round" RELATED [] synonym: "rounded" RELATED [] is_a: PATO:0000947 ! elliptic [Term] id: PATO:0000460 name: abnormal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "aberrant" RELATED [] synonym: "atypia" RELATED [] synonym: "atypical" RELATED [] synonym: "defective" RELATED [] is_a: PATO:0000069 ! deviation (from_normal) relationship: is_opposite_of PATO:0000461 ! normal [Term] id: PATO:0000461 name: normal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "average" RELATED [] is_a: PATO:0000068 ! qualitative relationship: is_opposite_of PATO:0000460 ! abnormal [Term] id: PATO:0000462 name: absent namespace: quality alt_id: PATO:0001996 def: "A quality denoting the lack of an entity." [thefreedictionary.:thefreedictionary.] comment: See documentation here: http://code.google.com/p/phenotype-ontologies/wiki/ModelingOfAbsence subset: absent_slim subset: mpath_slim subset: value_slim synonym: "absence" EXACT [] synonym: "absent from organism" EXACT [] is_a: PATO:0000070 ! amount disjoint_from: PATO:0000467 ! present relationship: is_opposite_of PATO:0000467 ! present relationship: reciprocal_of PATO:0001558 ! lacking processual parts relationship: reciprocal_of PATO:0002000 ! lacks all parts of type [Term] id: PATO:0000467 name: present namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's existence." [PATOC:GVG] subset: absent_slim subset: value_slim synonym: "present in organism" RELATED [] is_a: PATO:0000070 ! amount relationship: is_opposite_of PATO:0000462 ! absent [Term] id: PATO:0000470 name: increased amount namespace: quality alt_id: PATO:0000420 alt_id: PATO:0000650 def: "An amount which is relatively high." [PATOC:GVG] subset: value_slim synonym: "accessory" RELATED [] synonym: "increased" RELATED [] synonym: "increased number" EXACT [] synonym: "present in greater numbers in organism" EXACT [] synonym: "supernumerary" EXACT [] is_a: PATO:0000467 ! present is_a: PATO:0002300 ! increased quality intersection_of: PATO:0000070 ! amount intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001997 ! decreased amount [Term] id: PATO:0000573 name: increased length namespace: quality def: "A length quality which is relatively large." [PATOC:GVG] subset: value_slim synonym: "long" EXACT [] is_a: PATO:0000122 ! length is_a: PATO:0000586 ! increased size intersection_of: PATO:0000122 ! length intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000574 ! decreased length [Term] id: PATO:0000574 name: decreased length namespace: quality def: "A length quality which is relatively small." [PATOC:GVG] subset: value_slim synonym: "short" EXACT [] synonym: "shortened" RELATED [] synonym: "stubby" RELATED [] is_a: PATO:0000122 ! length is_a: PATO:0000587 ! decreased size intersection_of: PATO:0000122 ! length intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000573 ! increased length [Term] id: PATO:0000582 name: increased weight namespace: quality def: "A weight which is relatively high." [PATOC:GVG] subset: value_slim synonym: "heavy" EXACT [] synonym: "high weight" EXACT [] is_a: PATO:0000128 ! weight is_a: PATO:0002245 ! increased force intersection_of: PATO:0000128 ! weight intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000583 ! decreased weight [Term] id: PATO:0000583 name: decreased weight namespace: quality def: "A weight which is relatively low." [PATOC:GVG] subset: value_slim synonym: "light weight" EXACT [] synonym: "low weight" EXACT [] is_a: PATO:0000128 ! weight is_a: PATO:0002246 ! decreased force intersection_of: PATO:0000128 ! weight intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000582 ! increased weight [Term] id: PATO:0000584 name: hypertrophic namespace: quality def: "An increased size quality inhering in a bearer by virtue of the bearer's exhibiting enlargement of a cell or constituent group of cells (for example, organ)." [PATOC:MAH] subset: mpath_slim subset: value_slim synonym: "hypertrophy" NARROW [] is_a: PATO:0000595 ! increased volume relationship: is_opposite_of PATO:0000585 ! hypotrophic [Term] id: PATO:0000585 name: hypotrophic namespace: quality alt_id: PATO:0000412 def: "A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced size of a cell or constituent group of cells (for example, organ)." [PATOC:MAH] subset: mpath_slim subset: value_slim synonym: "shrunken" EXACT [] is_a: PATO:0000596 ! decreased volume relationship: is_opposite_of PATO:0000584 ! hypertrophic [Term] id: PATO:0000586 name: increased size namespace: quality alt_id: PATO:0001202 def: "A size quality which is relatively high." [PATOC:GVG] subset: value_slim synonym: "big" RELATED [] synonym: "enlarged" RELATED [] synonym: "expanded" RELATED [] synonym: "great" RELATED [] synonym: "large" RELATED [] is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000117 ! size intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000587 ! decreased size [Term] id: PATO:0000587 name: decreased size namespace: quality def: "A size quality which is relatively low." [PATOC:GVG] subset: value_slim synonym: "hypoplasia" NARROW [] synonym: "reduced" RELATED [] synonym: "small" RELATED [] synonym: "tiny" RELATED [] synonym: "underdeveloped" NARROW [] is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000117 ! size intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000586 ! increased size [Term] id: PATO:0000595 name: increased volume namespace: quality def: "A volume which is relatively high." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "high volume" EXACT [] synonym: "large volume" RELATED [] is_a: PATO:0000586 ! increased size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000596 ! decreased volume [Term] id: PATO:0000596 name: decreased volume namespace: quality def: "A volume which is relatively low." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "low volume" EXACT [] synonym: "small volume" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000595 ! increased volume [Term] id: PATO:0000599 name: decreased width namespace: quality def: "A width which is relatively small." [PATOC:GVG] subset: value_slim synonym: "narrow" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000600 ! increased width [Term] id: PATO:0000600 name: increased width namespace: quality def: "A width which is relatively large." [PATOC:GVG] subset: value_slim synonym: "broad" RELATED [] synonym: "wide" RELATED [] synonym: "wide/broad" RELATED [] is_a: PATO:0000586 ! increased size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000599 ! decreased width [Term] id: PATO:0000639 name: degenerate namespace: quality def: "A structural quality inhering in a bearer whose structure deteriorates or is lost over time due to an active pathological process." [PATOC:mb, PATOC:PortlandMeetingFeb2015] subset: mpath_slim subset: value_slim synonym: "degeneration" NARROW [] is_a: PATO:0002037 ! degeneration disjoint_from: PATO:0002038 ! non-degenerate relationship: has_part PATO:0000585 ! hypotrophic relationship: is_opposite_of PATO:0002038 ! non-degenerate [Term] id: PATO:0000644 name: hyperplastic namespace: quality alt_id: PATO:0000943 def: "A increased size quality inhering in an organ or tissue by virtue of the bearer's exhibiting increased number of cells." [Wikipedia:http\://en.wikipedia.org/wiki/Hyperplastic] subset: mpath_slim subset: value_slim synonym: "hyperplasia" EXACT [] synonym: "overdeveloped" RELATED [] is_a: PATO:0000586 ! increased size relationship: is_opposite_of PATO:0000645 ! hypoplastic [Term] id: PATO:0000645 name: hypoplastic namespace: quality alt_id: PATO:0000942 def: "A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced number of cells within an organ or tissue." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "hypoplasia" EXACT [] synonym: "underdeveloped" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0002290 ! aplastic/hypoplastic relationship: is_opposite_of PATO:0000644 ! hyperplastic [Term] id: PATO:0000911 name: decreased rate namespace: quality def: "A rate which is relatively low." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "slow rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000161 ! rate intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000912 ! increased rate [Term] id: PATO:0000912 name: increased rate namespace: quality def: "A rate which is relatively high." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "fast rate" EXACT [] synonym: "high rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000161 ! rate intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000911 ! decreased rate [Term] id: PATO:0000918 name: volume namespace: quality def: "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies." [PATOC:GVG] subset: attribute_slim subset: mpath_slim subset: scalar_slim is_a: PATO:0001710 ! 3-D extent [Term] id: PATO:0000921 name: width namespace: quality def: "A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite." [PATOC:GVG] subset: attribute_slim subset: scalar_slim synonym: "breadth" RELATED [] is_a: PATO:0001708 ! 1-D extent [Term] id: PATO:0000944 name: sharpness namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point." [PATOC:GVG] subset: attribute_slim subset: cell_quality synonym: "apiculate" EXACT [] is_a: PATO:0000052 ! shape [Term] id: PATO:0000947 name: elliptic namespace: quality def: "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ellipse-shaped" EXACT [] synonym: "ellipsoid" EXACT [] synonym: "elliptical" EXACT [] synonym: "oval" RELATED [] synonym: "ovoid" RELATED [] is_a: PATO:0002318 ! superelliptic [Term] id: PATO:0001018 name: physical quality namespace: quality alt_id: PATO:0002079 def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." [PATOC:GVG] subset: attribute_slim synonym: "relational physical quality" EXACT [] xref: Wikipedia:Physical_property is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001035 name: force namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's rate of change of momentum." [thesaurus.maths:thesaurus.maths] subset: attribute_slim subset: scalar_slim synonym: "force amplitude" EXACT [] is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001159 name: concentrated namespace: quality def: "A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0000033 ! concentration of [Term] id: PATO:0001162 name: increased concentration namespace: quality def: "A concentration which is higher relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "high concentration" EXACT [] is_a: PATO:0001159 ! concentrated is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001163 ! decreased concentration [Term] id: PATO:0001163 name: decreased concentration namespace: quality def: "A concentration which is lower relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "low concentration" EXACT [] is_a: PATO:0001159 ! concentrated is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001162 ! increased concentration [Term] id: PATO:0001199 name: linear namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being narrow, with the two opposite margins parallel." [ISBN:0881923214] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001236 name: process quality namespace: quality alt_id: PATO:0001239 alt_id: PATO:0001240 def: "A quality which inheres in an process." [PATOC:GVG] comment: See comments of relational quality of a physical entity. synonym: "quality of a process" EXACT [] synonym: "quality of occurrent" EXACT [] synonym: "quality of process" EXACT [] synonym: "relational quality of occurrent" EXACT [] is_a: PATO:0000001 ! quality disjoint_from: PATO:0001241 ! physical object quality [Term] id: PATO:0001241 name: physical object quality namespace: quality alt_id: PATO:0001237 alt_id: PATO:0001238 def: "A quality which inheres in a continuant." [PATOC:GVG] comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. synonym: "monadic quality of a continuant" EXACT [] synonym: "monadic quality of an object" NARROW [] synonym: "monadic quality of continuant" NARROW [] synonym: "multiply inhering quality of a physical entity" EXACT [] synonym: "quality of a continuant" EXACT [] synonym: "quality of a single physical entity" EXACT [] synonym: "quality of an object" EXACT [] synonym: "quality of continuant" EXACT [] xref: snap:Quality is_a: PATO:0000001 ! quality [Term] id: PATO:0001291 name: electromagnetic (EM) radiation quality namespace: quality def: "A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation." [Wikipedia:http\://en.wikipedia.org/wiki/Electromagnetic_radiation] subset: attribute_slim is_a: PATO:0001739 ! radiation quality [Term] id: PATO:0001300 name: optical quality namespace: quality def: "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001291 ! electromagnetic (EM) radiation quality [Term] id: PATO:0001340 name: hermaphrodite namespace: quality def: "A biological sex quality inhering in an organism or a population with both male and female sexual organs in one individual." [MGED:MGED] subset: value_slim synonym: "intersex" EXACT [] is_a: PATO:0001894 ! phenotypic sex [Term] id: PATO:0001355 name: convex namespace: quality def: "A shape quality that obtains by virtue of the bearer having inward facing edges; having a surface or boundary that curves or bulges outward, as the exterior of a sphere." [PATOC:GVG] subset: cell_quality subset: value_slim is_a: PATO:0002005 ! concavity relationship: is_opposite_of PATO:0001857 ! concave [Term] id: PATO:0001374 name: ploidy namespace: quality def: "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." [Wikipedia:http\://en.wikipedia.org/wiki/Ploidy] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001377 name: polyploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Polyploid] subset: cell_quality subset: value_slim is_a: PATO:0001393 ! euploid [Term] id: PATO:0001381 name: triploid namespace: quality def: "A polyploidy quality inhering in a bearer by virtue of the bearer's containing three homologous sets of chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Triploid] subset: cell_quality subset: value_slim is_a: PATO:0001377 ! polyploid [Term] id: PATO:0001382 name: tetraploid namespace: quality def: "A polyploidy quality inhering in a bearer by virtue of the bearer's containing four homologous sets of chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Tetraploid] subset: cell_quality subset: value_slim is_a: PATO:0001377 ! polyploid [Term] id: PATO:0001384 name: hexaploid namespace: quality def: "A polyploidy quality inhering in a bearer by virtue of the bearer's containing six homologous sets of chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Hexaploid] subset: cell_quality subset: value_slim is_a: PATO:0001377 ! polyploid [Term] id: PATO:0001393 name: euploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Euploid] subset: cell_quality subset: value_slim is_a: PATO:0001374 ! ploidy [Term] id: PATO:0001396 name: cellular quality namespace: quality def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001404 name: nucleate quality namespace: quality def: "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001405 name: anucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0001406 name: binucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001908 ! multinucleate [Term] id: PATO:0001407 name: mononucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001408 name: ciliatedness namespace: quality def: "A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body." [Wikipedia:http\://en.wikipedia.org/wiki/Ciliated] subset: cell_quality subset: value_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001419 name: sharp namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge." [PATOC:GVG] subset: cell_quality subset: value_slim is_a: PATO:0000944 ! sharpness [Term] id: PATO:0001421 name: alive namespace: quality def: "A viability quality inhering in a bearer by virtue of the bearer's condition before death." [PATOC:GVG] subset: value_slim is_a: PATO:0000169 ! viability [Term] id: PATO:0001422 name: dead namespace: quality def: "A viability quality inhering in a bearer by virtue of the cessation of the bearer's life." [PATOC:GVG] subset: value_slim is_a: PATO:0000169 ! viability [Term] id: PATO:0001450 name: edematous namespace: quality def: "A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of extracellular fluid." [thefreedictionary.com:thefreedictionary.com] subset: mpath_slim subset: value_slim synonym: "edema" NARROW [] synonym: "edemic" EXACT [] synonym: "oedema" NARROW [] synonym: "oedematous" EXACT [] synonym: "oedemic" EXACT [] is_a: PATO:0000025 ! composition [Term] id: PATO:0001475 name: increased position namespace: quality def: "A position which is relatively high." [PATOC:GVG] subset: value_slim synonym: "high position" RELATED [] is_a: PATO:0000140 ! position is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000140 ! position intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001476 ! decreased position [Term] id: PATO:0001476 name: decreased position namespace: quality def: "A positional which is relatively low." [PATOC:GVG] subset: value_slim synonym: "low position" RELATED [] is_a: PATO:0000140 ! position is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000140 ! position intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001475 ! increased position [Term] id: PATO:0001555 name: has number of namespace: quality def: "The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts." [PATOC:CJM] subset: attribute_slim subset: relational_slim synonym: "cardinality" RELATED [] synonym: "extra or missing physical or functional parts" EXACT [] synonym: "has or lacks parts of type" EXACT [] synonym: "mereological quality" EXACT [] synonym: "number" RELATED [] synonym: "number of" EXACT [] xref: OBO_REL:has_part is_a: PATO:0001241 ! physical object quality relationship: reciprocal_of PATO:0000070 ! amount [Term] id: PATO:0001558 name: lacking processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0001564 ! extra or missing processual parts relationship: reciprocal_of PATO:0000462 ! absent [Term] id: PATO:0001561 name: having extra processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's having additional processual parts." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "having supernumerary processual parts" EXACT [] is_a: PATO:0001564 ! extra or missing processual parts [Term] id: PATO:0001562 name: decreased mass namespace: quality alt_id: PATO:0000579 def: "A mass which is lower than normal or average." [PATO:GVG] subset: value_slim synonym: "low mass" EXACT [] synonym: "small mass" EXACT [] is_a: PATO:0000125 ! mass is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000125 ! mass intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001563 ! increased mass [Term] id: PATO:0001563 name: increased mass namespace: quality alt_id: PATO:0000578 def: "A mass which is higher than normal or average." [PATO:GVG] subset: value_slim synonym: "high mass" EXACT [] synonym: "large mass" EXACT [] is_a: PATO:0000125 ! mass is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000125 ! mass intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001562 ! decreased mass [Term] id: PATO:0001564 name: extra or missing processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's processual parts." [PATOC:GVG] subset: relational_slim is_a: PATO:0001236 ! process quality [Term] id: PATO:0001591 name: curvature namespace: quality def: "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." [WordNet:WordNet] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001592 name: increased curvature namespace: quality def: "A curvature which is relatively high." [PATO:GVG] subset: value_slim is_a: PATO:0000406 ! curved is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000406 ! curved intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001593 ! decreased curvature [Term] id: PATO:0001593 name: decreased curvature namespace: quality def: "A curvature which is relatively low." [PATO:GVG] subset: value_slim is_a: PATO:0000406 ! curved is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000406 ! curved intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0001592 ! increased curvature [Term] id: PATO:0001708 name: 1-D extent namespace: quality def: "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." [PATOC:GVG] subset: attribute_slim synonym: "1-D size" EXACT [] is_a: PATO:0000117 ! size [Term] id: PATO:0001710 name: 3-D extent namespace: quality def: "A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions." [PATOC:GVG] subset: attribute_slim synonym: "3D size" EXACT [] is_a: PATO:0000117 ! size [Term] id: PATO:0001739 name: radiation quality namespace: quality def: "A quality that inheres in an bearer by virtue of how that bearer interacts with radiation." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001799 name: ruffled namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's exhibiting disturbance of its smoothness or regularity." [.thefreedictionary.com:.thefreedictionary.com] subset: cell_quality subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001857 name: concave namespace: quality def: "A shape quality in a bearer by virtue of the bearer's curving inward." [WordNet:WordNet] subset: cell_quality subset: value_slim is_a: PATO:0002005 ! concavity relationship: is_opposite_of PATO:0001355 ! convex [Term] id: PATO:0001869 name: pathological namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's being abnormal and having a destructive effect on living tissue." [PATOC:cjm] subset: abnormal_slim subset: value_slim is_a: PATO:0000460 ! abnormal [Term] id: PATO:0001875 name: triangular namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having three angles." [wordreference:wordreference] subset: cell_quality subset: value_slim synonym: "delta shaped" RELATED [] synonym: "deltoid" EXACT [] synonym: "triangle" RELATED [] synonym: "triangle-shaped" RELATED [] is_a: PATO:0002006 ! 2-D shape [Term] id: PATO:0001894 name: phenotypic sex namespace: quality def: "An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics." [] subset: attribute_slim is_a: PATO:0000047 ! biological sex [Term] id: PATO:0001908 name: multinucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001955 name: cuneate namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being narrowly triangular, wider at the apex and tapering toward the base." [wordreference:wordreference] subset: value_slim synonym: "wedge-shaped" EXACT [] is_a: PATO:0001875 ! triangular [Term] id: PATO:0001992 name: cellularity namespace: quality def: "An organismal quality inhering in a bearer by virtue of the bearer's consisting cells." [PATOC:GVG] subset: attribute_slim subset: scalar_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0001993 name: multicellular namespace: quality def: "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." [PATOC:GVG] subset: value_slim is_a: PATO:0001992 ! cellularity [Term] id: PATO:0001995 name: organismal quality namespace: quality def: "A quality that inheres in an entire organism or part of an organism." [PATOC:CJM] is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001997 name: decreased amount namespace: quality alt_id: PATO:0000419 alt_id: PATO:0000468 def: "An amount which is relatively low." [PATOC:GVG] subset: value_slim synonym: "decreased" RELATED [] synonym: "decreased number" EXACT [] synonym: "present in fewer numbers in organism" EXACT [] synonym: "reduced" RELATED [] synonym: "subnumerary" RELATED [] is_a: PATO:0000467 ! present is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0000070 ! amount intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0000470 ! increased amount [Term] id: PATO:0001999 name: lacks parts or has fewer parts of type namespace: quality def: "The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type." [PATOC:CJM] subset: relational_slim synonym: "loss of" EXACT [] is_a: PATO:0002083 ! altered number of [Term] id: PATO:0002000 name: lacks all parts of type namespace: quality alt_id: PATO:0001557 def: "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity." [PATOC:CJM] comment: Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2. subset: relational_slim synonym: "lacks all physical parts of type" EXACT [] xref: OBO_REL:lacks_part is_a: PATO:0001999 ! lacks parts or has fewer parts of type relationship: reciprocal_of PATO:0000462 ! absent [Term] id: PATO:0002001 name: has fewer parts of type namespace: quality alt_id: PATO:0001569 def: "The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly." [PATOC:CJM] comment: Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type. subset: relational_slim synonym: "decreased number of" EXACT [] synonym: "has decreased number of" EXACT [] synonym: "has fewer physical parts of type" EXACT [] is_a: PATO:0001999 ! lacks parts or has fewer parts of type is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001999 ! lacks parts or has fewer parts of type intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002002 ! has extra parts of type [Term] id: PATO:0002002 name: has extra parts of type namespace: quality alt_id: PATO:0001560 def: "The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." [PATOC:CJM] comment: In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q= E2=finger. subset: relational_slim synonym: "has extra parts of" EXACT [] synonym: "has increased number of" EXACT [] synonym: "having extra physical parts" EXACT [] synonym: "having supernumerary physical parts" EXACT [] synonym: "increased number of" EXACT [] is_a: PATO:0002083 ! altered number of is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002083 ! altered number of intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002001 ! has fewer parts of type [Term] id: PATO:0002005 name: concavity namespace: quality def: "Surface shape that refers to the inward or outward curvature of the surface." [PATOC:MAH] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0002006 name: 2-D shape namespace: quality def: "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." [PATOC:CJM] subset: attribute_slim synonym: "2-D projection" RELATED [] synonym: "cross-sectional" RELATED [] is_a: PATO:0000052 ! shape [Term] id: PATO:0002007 name: convex 3-D shape namespace: quality def: "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." [PATOC:CJM] comment: Use this term or an is_a child of this term when the entire shape of the object is known. subset: attribute_slim xref: Image:http\://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png is_a: PATO:0002266 ! 3-D shape relationship: has_cross_section PATO:0002006 ! 2-D shape relationship: is_opposite_of PATO:0002008 ! concave 3-D shape [Term] id: PATO:0002008 name: concave 3-D shape namespace: quality def: "A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave." [PATOC:CJM] subset: attribute_slim xref: Image:http\://en.wikipedia.org/wiki/Image\:Convex_polygon_illustration2.png is_a: PATO:0002266 ! 3-D shape relationship: has_part PATO:0001857 ! concave relationship: is_opposite_of PATO:0002007 ! convex 3-D shape [Term] id: PATO:0002037 name: degeneration namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer exhibiting deterioration of its structure." [PATOC:GVG] subset: attribute_slim subset: scalar_slim is_a: PATO:0000141 ! structure created_by: george creation_date: 2009-02-03T11:13:19Z [Term] id: PATO:0002038 name: non-degenerate namespace: quality def: "A structural quality inhering in a bearer whose structure which does not deteriorate." [PATOC:GVG] subset: value_slim synonym: "not degenerate" EXACT [] is_a: PATO:0002037 ! degeneration relationship: is_opposite_of PATO:0000639 ! degenerate created_by: george creation_date: 2009-02-03T11:14:54Z [Term] id: PATO:0002062 name: physical quality of a process namespace: quality subset: attribute_slim is_a: PATO:0001236 ! process quality created_by: george creation_date: 2009-06-05T09:16:46Z [Term] id: PATO:0002063 name: columnar namespace: quality def: "A shape inhering in a bearer by virtue of the bearer's being elongated and cylindrical." [PATOC:me] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape created_by: George Gkoutos creation_date: 2009-07-01T01:44:06Z [Term] id: PATO:0002065 name: star shaped namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center." [PATOC:me] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "stellate" EXACT [] is_a: PATO:0000052 ! shape created_by: George Gkoutos creation_date: 2009-07-01T01:48:19Z [Term] id: PATO:0002083 name: altered number of namespace: quality def: "Having extra or fewer parts." [PATOC:GVG] subset: attribute_slim subset: relational_slim is_a: PATO:0001555 ! has number of created_by: George Gkoutos creation_date: 2009-09-21T10:41:58Z [Term] id: PATO:0002131 name: abduction namespace: quality def: "A displaced angular placement quality inhering in a body part by virtue of the bearer's movement away from the medial plane of the body." [wikipedia:wikipedia] subset: attribute_slim subset: relational_slim is_a: PATO:0002168 ! displaced to created_by: george creation_date: 2009-10-13T06:38:53Z [Term] id: PATO:0002133 name: adduction namespace: quality def: "A displaced angular placement quality inhering in a body part by virtue of the bearer's movement closer the medial plane of the body." [wikipedia:wikipedia] comment: This term is also used in reference to the operation of the muscle in anatomy or musculature. subset: attribute_slim subset: relational_slim is_a: PATO:0002168 ! displaced to created_by: george creation_date: 2009-10-13T06:41:39Z [Term] id: PATO:0002164 name: curved medial namespace: quality def: "A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the middle." [PATOC:GVG] subset: value_slim is_a: PATO:0000406 ! curved created_by: george creation_date: 2009-12-02T10:06:21Z [Term] id: PATO:0002168 name: displaced to namespace: quality def: "An angular placement quality inhering in a bearer by virtue of the bearer being changed in position in relation to another entity." [PATOC:GVG] subset: relational_slim synonym: "mislocalised to" RELATED [] is_a: PATO:0000133 ! orientation created_by: george creation_date: 2010-01-14T04:45:18Z [Term] id: PATO:0002182 name: molecular quality namespace: quality alt_id: PATO:0002061 def: "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." [PATOC:GVG] synonym: "relational molecular quality" EXACT [] is_a: PATO:0001241 ! physical object quality created_by: George Gkoutos creation_date: 2010-03-10T03:18:15Z [Term] id: PATO:0002239 name: hourglass-shaped namespace: quality def: "A concave 3-D shape that inheres in the bearer by virtue of the bearer's nearly) symmetric shape wide at its ends and narrow in the middle, resembling the figure of number 8." [url:http\://en.wikipedia.org/wiki/Hourglass-shaped] subset: value_slim synonym: "figure 8 shaped" EXACT [] is_a: PATO:0002008 ! concave 3-D shape created_by: george creation_date: 2010-07-23T02:25:24Z [Term] id: PATO:0002245 name: increased force namespace: quality def: "A force which relative high." [PATOC:GVG] subset: value_slim synonym: "increased force amplitude" EXACT [] is_a: PATO:0001035 ! force is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001035 ! force intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002246 ! decreased force created_by: george creation_date: 2010-08-04T11:12:20Z [Term] id: PATO:0002246 name: decreased force namespace: quality def: "A force which is relative low." [PATOC:GVG] subset: value_slim synonym: "decreased force amplitude" EXACT [] is_a: PATO:0001035 ! force is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001035 ! force intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002245 ! increased force created_by: george creation_date: 2010-08-04T11:13:13Z [Term] id: PATO:0002247 name: degree of pigmentation namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having or lacking of substances produced by living organisms that have a color resulting from selective color absorption." [url:http\://en.wikipedia.org/wiki/Biological_pigment] subset: attribute_slim subset: scalar_slim is_a: PATO:0000141 ! structure relationship: correlates_with PATO:0000014 ! color created_by: george creation_date: 2010-08-09T04:14:00Z [Term] id: PATO:0002248 name: pigmented namespace: quality def: "A degree of pigmentation quality inhering in a bearer by virtue of the bearer's having substances produced by living organisms that have a color resulting from selective color absorption." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0002247 ! degree of pigmentation disjoint_from: PATO:0002249 ! unpigmented relationship: is_opposite_of PATO:0002249 ! unpigmented created_by: george creation_date: 2010-08-09T04:16:49Z [Term] id: PATO:0002249 name: unpigmented namespace: quality def: "A degree of pigmentation quality inhering in a bearer by virtue of the bearer's lacking substances produced by living organisms that have a color resulting from selective color absorption." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "depigmented" EXACT [] is_a: PATO:0002247 ! degree of pigmentation relationship: is_opposite_of PATO:0002248 ! pigmented created_by: george creation_date: 2010-08-09T04:17:04Z [Term] id: PATO:0002250 name: increased pigmentation namespace: quality def: "A degree of pigmentation quality that is relatively high." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "hyperpigmented" EXACT [] is_a: PATO:0002248 ! pigmented is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002248 ! pigmented intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002251 ! decreased pigmentation created_by: george creation_date: 2010-08-09T04:17:19Z [Term] id: PATO:0002251 name: decreased pigmentation namespace: quality def: "A degree of pigmentation quality that is relative low." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "hypopigmented" EXACT [] is_a: PATO:0002248 ! pigmented is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0002248 ! pigmented intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002250 ! increased pigmentation created_by: george creation_date: 2010-08-09T04:17:37Z [Term] id: PATO:0002258 name: pointed namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having a point." [PATOC:http\://www.merriam-webster.com/dictionary/pointed] subset: value_slim is_a: PATO:0001419 ! sharp created_by: george creation_date: 2010-09-08T03:15:16Z [Term] id: PATO:0002266 name: 3-D shape namespace: quality def: "A shape that inheres in a 3 dimensional entity." [PATOC:OREGON] is_a: PATO:0000052 ! shape created_by: george creation_date: 2010-10-05T12:31:16Z [Term] id: PATO:0002282 name: increased mobility namespace: quality def: "A mobility which is relative high." [PATO:GVG] subset: value_slim is_a: PATO:0000299 ! mobile is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000299 ! mobile intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002283 ! decreased mobility created_by: george creation_date: 2011-03-09T09:16:03Z [Term] id: PATO:0002283 name: decreased mobility namespace: quality def: "A mobility which is relative low." [PATOC:GVG] subset: value_slim is_a: PATO:0000299 ! mobile is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000299 ! mobile intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002282 ! increased mobility created_by: george creation_date: 2011-03-09T09:16:47Z [Term] id: PATO:0002290 name: aplastic/hypoplastic namespace: quality is_a: PATO:0001241 ! physical object quality created_by: George Gkoutos creation_date: 2011-04-18T05:11:33Z [Term] id: PATO:0002300 name: increased quality namespace: quality def: "A quality that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002301 ! decreased quality created_by: George Gkoutos creation_date: 2011-06-16T06:39:43Z [Term] id: PATO:0002301 name: decreased quality namespace: quality def: "A quality that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002300 ! increased quality created_by: George Gkoutos creation_date: 2011-06-16T06:40:15Z [Term] id: PATO:0002302 name: decreased process quality namespace: quality def: "A quality of a process that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001236 ! process quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002304 ! increased process quality created_by: George Gkoutos creation_date: 2011-06-16T06:50:59Z [Term] id: PATO:0002303 name: decreased object quality namespace: quality def: "A quality of an object that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002305 ! increased object quality created_by: George Gkoutos creation_date: 2011-06-16T06:51:54Z [Term] id: PATO:0002304 name: increased process quality namespace: quality def: "A quality of a process that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001236 ! process quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002302 ! decreased process quality created_by: George Gkoutos creation_date: 2011-06-16T06:53:08Z [Term] id: PATO:0002305 name: increased object quality namespace: quality def: "A quality of an object that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: is_opposite_of PATO:0002303 ! decreased object quality created_by: George Gkoutos creation_date: 2011-06-16T06:54:01Z [Term] id: PATO:0002318 name: superelliptic namespace: quality def: "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" [wiktionary:superellipse] synonym: "Lamé curve" EXACT [] is_a: PATO:0002006 ! 2-D shape created_by: George Gkoutos creation_date: 2011-10-12T12:45:16Z [Term] id: PATO:0002486 name: multi-organismal process quality namespace: quality def: "A quality inhering in a process by virtue of that process having two or more organisms as participants." [PATOC:DS] subset: attribute_slim is_a: PATO:0001236 ! process quality created_by: gkoutos creation_date: 2013-10-10T04:08:44Z [Term] id: PATO:0002487 name: single organismal process quality namespace: quality def: "A quality inhering in a process by virtue of that process having exactly one organism as a participant." [PATOC:DS] subset: attribute_slim is_a: PATO:0001236 ! process quality created_by: gkoutos creation_date: 2013-10-10T04:09:51Z [Term] id: PATO:0002505 name: nucleated namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality created_by: gkoutos creation_date: 2013-10-21T05:44:34Z [Term] id: PATO:0005024 name: longitudinal orientation namespace: quality def: "An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed along the longitudinal or anterior-posterior axis." [PATOC:WD] subset: value_slim is_a: PATO:0000133 ! orientation created_by: wasila.dahdul creation_date: 2014-10-17T14:24:19Z [Term] id: PATO:0015001 name: absence due to degeneration namespace: quality def: "Absence due to a degenerative process." [PATOC:PortlandMeetingFeb2015] subset: absent_slim subset: value_slim is_a: PATO:0000462 ! absent is_a: PATO:0000639 ! degenerate intersection_of: PATO:0000462 ! absent intersection_of: PATO:0000639 ! degenerate created_by: cjm [Term] id: PATO:0040012 name: plug shaped namespace: quality def: "A shape that is in the form of a plug, being tube-like and expanded on one end." [https://orcid.org/0000-0003-3162-7490] synonym: "plug like" EXACT [] is_a: PATO:0000052 ! shape property_value: http://purl.org/dc/elements/1.1/date 2018-11-12T18:24:41Z xsd:dateTime created_by: http://orcid.org/0000-0001-5208-3432 [Term] id: PATO:0040025 name: lesioned namespace: quality def: "A structural quality which is held by a bearer where a localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part is present." [NCIT:C3824] is_a: PATO:0000141 ! structure created_by: http://orcid.org/0000-0001-5208-3432 [Term] id: PLANA:0000001 name: Stage 1 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development, 0 - 2 days post-egg capsule deposition at 20˚C. Zygote and dispersed blastomere cleavage in a yolk syncytium." [] xref: PMID:28072387 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4897 [Term] id: PLANA:0000002 name: Stage 2 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development defined by a unique gene expression signature and morphology, 2 - 3 days post-egg capsule deposition at 20˚C. Sphere formation. A fraction of the blastomeres differentiate into temporary embryonic tissues that provide form and function to the embryo. Undifferentiated blastomeres remain in the embryonic wall." [] synonym: "protosphere" EXACT [] xref: PMID:28072387 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/Stage2.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 2 embryo. Scale bar = 100um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4898 [Term] id: PLANA:0000003 name: Stage 3 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development defined by a unique gene expression signature and morphology, 2 - 4 days post-egg capsule deposition at 20˚C. Dispersed blastomere cleavage in the embryonic wall of nascent spheres. Yolk ingestion into the gut cavity." [] xref: PMID:28072387 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/Stage3.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 3 embryo. Scale bar = 100um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4899 [Term] id: PLANA:0000004 name: Stage 4 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development defined by a unique gene expression signature and morphology, 3 - 5 days post-egg capsule deposition at 20˚C. Dispersed blastomere cleavage in the embryonic wall. Yolk ingestion into the gut cavity. Early embryonic gut formation." [] xref: PMID:28072387 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/stage4.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 4 embryo. Scale bar = 100um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4900 [Term] id: PLANA:0000005 name: Stage 5 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development defined by a unique gene expression signature and morphology, 5-7 days post-egg capsule deposition at 20˚C. Organogenesis onset. Downregulation of early embryo enriched transcripts and birth of adult lineages within the blastomere population. Early embryonic gut formation continues. Yolk ingestion into the gut cavity." [] xref: PMID:28072387 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/stage5.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 5 embryo. Scale bar = 100um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4901 [Term] id: PLANA:0000006 name: Stage 6 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development defined by a unique gene expression signature and morphology, 7 - 9 days post-egg capsule deposition at 20˚C. Organogenesis and morphogenesis. Definitive organ formation. Temporary embryonic cell types degenerate. Embryo elongation." [] xref: PMID:28072387 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/stage6.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 6 embryo. Scale bar = 100um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4902 [Term] id: PLANA:0000007 name: Stage 7 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development defined by a unique gene expression signature and morphology, 9 - 11 days post-egg capsule deposition at 20˚C. Organogenesis and organ maturation continues. Embryos elongated. Eyes just visible. Onset of gliding motility." [] xref: PMID:28072387 xref: PMID:28812561 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/stage7.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 7 embryo. Scale bar = 100um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4903 [Term] id: PLANA:0000008 name: Stage 8 namespace: Schmidtea_mediterranea_Developmental_Stages def: "A stage of Smed embryonic development defined by a unique gene expression signature and morphology, 13 - 15 days post-egg capsule deposition at 20˚C. Organogenesis and organ maturation continues. Hatching." [] synonym: "hatchling" EXACT [] synonym: "newborn hatchling" EXACT [] xref: PMID:28072387 is_a: UBERON:0000068 ! embryo stage relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/stage8.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 8 embryo. Scale bar = 100um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4904 [Term] id: PLANA:0000009 name: sigma neoblast namespace: Planarian_Anatomy def: "A heterogeneous subpopulation of neoblasts with enriched expression of SoxP-1 and SoxP-2 thought to contain both pluripotent stem cells and tissue-specific progenitors." [] synonym: "sigma class neoblast" EXACT [] synonym: "sigma-class neoblast" EXACT [] xref: PMID:15972844 xref: PMID:25017721 xref: PMID:25956527 xref: PMID:26457503 xref: PMID:26651295 xref: PMID:27013241 xref: PMID:27150006 xref: PMID:27542689 xref: PMID:28287248 xref: PMID:28686611 xref: PMID:28757112 xref: PMID:29557542 xref: PMID:29674432 xref: PMID:29906446 is_a: PLANA:0000429 ! neoblast property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4879 [Term] id: PLANA:0000011 name: protonephridial progenitor cell namespace: Planarian_Anatomy def: "Neoblasts and post-mitotic, differentiating daughters coexpressing POU2-3, six1/2-2, Sal1, Eya and Osr,required for maintenance and regeneration of protonephridial cell types." [] xref: PMID:24523458 xref: PMID:28072387 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000012 name: neural progenitor cell namespace: Planarian_Anatomy def: "Neoblasts and their differentiating daughters implicated in maintenance and regeneration of different tissues in the nervous system." [] synonym: "neural committed stem cell" EXACT [] synonym: "neural precursor cell" EXACT [] synonym: "neural progenitor cell" EXACT [] synonym: "neuronal progenitor" EXACT [] xref: PMID:21282632 xref: PMID:24173799 xref: PMID:25356635 xref: PMID:26057828 xref: PMID:26525673 xref: PMID:28072387 xref: PMID:29674432 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000013 name: visceral musculature namespace: Planarian_Anatomy def: "Musculature surrounding internal organs of the body." [] synonym: "visceral muscle" EXACT [] xref: PMID:26904543 xref: PMID:30471994 is_a: PLANA:0000431 ! organ relationship: part_of PLANA:0000428 ! musculature system property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/visceralmusculature.png {comment="Image is an electron micrograph depicting the visceral musculature (arrowheads) that lies beneath the gut. The gut is identifiable by the collection of darkly stained lipid droplets in the top right corner and the white of the lumen at the top of the image. Scale bar is 10um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4955 [Term] id: PLANA:0000014 name: zeta neoblast namespace: Planarian_Anatomy def: "An abundant neoblast subclass consisting of p53+, zfp1+ progenitors required for maintenance and regeneration of epidermal cell type(s)." [] synonym: "zeta" EXACT [] synonym: "zeta class" EXACT [] synonym: "zeta class neoblast" EXACT [] synonym: "zeta-class neoblast" EXACT [] synonym: "zeta-neoblast" EXACT [] xref: PMID:25017721 xref: PMID:25956527 xref: PMID:26457503 xref: PMID:26651295 xref: PMID:27013241 xref: PMID:27150006 xref: PMID:27542689 xref: PMID:28292427 xref: PMID:28757112 xref: PMID:28807897 xref: PMID:29158443 xref: PMID:29557542 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:29906446 is_a: PLANA:0000033 ! epidermal progenitor cell is_a: PLANA:0000429 ! neoblast relationship: part_of PLANA:0004529 ! integumental system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4970 [Term] id: PLANA:0000015 name: non ciliated epithelial cell namespace: Planarian_Anatomy def: "An epithelial cell lacking cilia." [] is_a: PLANA:0000100 ! epithelial cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nonciliatedepithelialcell.png {comment="Image is an electron micrograph of the dorsal side of the animal where there is a transition from nonciliated epidermal cells to ciliated ones. On the left side of the image are the ciliated cells and on the right are the nonciliated. A few nonciliated have been marked with arrowheads. Scale bar is 10um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4718 [Term] id: PLANA:0000016 name: pharynx namespace: Planarian_Anatomy def: "A plicate and protrusible organ that is the sole point of entry and exit for the Triclad gut. It contains epithelial, muscular, secretory and neuronal cell types." [] synonym: "definitive pharynx" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:15866156 xref: PMID:16033796 xref: PMID:16311336 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17376870 xref: PMID:17390146 xref: PMID:17670787 xref: PMID:17905225 xref: PMID:17942485 xref: PMID:18063755 xref: PMID:18063757 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:18456843 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:19174194 xref: PMID:19211673 xref: PMID:19247960 xref: PMID:19766622 xref: PMID:19852954 xref: PMID:19933103 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:20422023 xref: PMID:20511647 xref: PMID:20599901 xref: PMID:20707997 xref: PMID:20865784 xref: PMID:20967238 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21295483 xref: PMID:21356107 xref: PMID:21458439 xref: PMID:21664348 xref: PMID:21747960 xref: PMID:21806978 xref: PMID:21828097 xref: PMID:21852957 xref: PMID:21894189 xref: PMID:21937596 xref: PMID:22125640 xref: PMID:22339734 xref: PMID:22371573 xref: PMID:22385657 xref: PMID:22411224 xref: PMID:22439894 xref: PMID:22451003 xref: PMID:22543868 xref: PMID:22884275 xref: PMID:23079596 xref: PMID:23123964 xref: PMID:23250205 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23405188 xref: PMID:23629965 xref: PMID:23652002 xref: PMID:23954785 xref: PMID:24040508 xref: PMID:24063805 xref: PMID:24120894 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24238224 xref: PMID:24704339 xref: PMID:24737865 xref: PMID:24922054 xref: PMID:25017721 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25558068 xref: PMID:25725068 xref: PMID:25956527 xref: PMID:26062938 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26459857 xref: PMID:26525673 xref: PMID:26711341 xref: PMID:27034770 xref: PMID:27063937 xref: PMID:27074666 xref: PMID:27122174 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27240733 xref: PMID:27441386 xref: PMID:27501047 xref: PMID:27551436 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:27654173 xref: PMID:28072387 xref: PMID:28126842 xref: PMID:28171748 xref: PMID:28245923 xref: PMID:28287248 xref: PMID:28292427 xref: PMID:28434803 xref: PMID:28461239 xref: PMID:28495872 xref: PMID:28686611 xref: PMID:28807897 xref: PMID:28893948 xref: PMID:29291981 xref: PMID:29674431 xref: PMID:29906446 xref: PMID:30194301 xref: PMID:30237141 xref: PMID:30282036 xref: PMID:30383829 xref: PMID:30399335 xref: PMID:30471994 xref: PMID:30485821 xref: PMID:30729158 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: PLANA:0000431 ! organ relationship: existence_starts_during_or_after PLANA:0000005 ! Stage 5 relationship: part_of PLANA:0000049 ! digestive system relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4766 [Term] id: PLANA:0000017 name: photoreceptor neuron namespace: Planarian_Anatomy def: "Bipolar photoreceptor neurons with dendritic projections into the optic cup and axons that innervate the underlying brain." [] synonym: "neuronal photoreceptive cell" EXACT [] synonym: "optical neuron" EXACT [] synonym: "photoreceptive neuron" EXACT [] synonym: "photoreceptor cell" EXACT [] synonym: "photosensitive cell" EXACT [] synonym: "PRN" EXACT [] synonym: "visual neuron" EXACT [] xref: ISBN:9780070316607 xref: PMID:16033796 xref: PMID:17251262 xref: PMID:17390146 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:17942485 xref: PMID:18202849 xref: PMID:19048075 xref: PMID:20967238 xref: PMID:21282632 xref: PMID:21852957 xref: PMID:22339734 xref: PMID:22411224 xref: PMID:22427692 xref: PMID:22445864 xref: PMID:22549959 xref: PMID:22884275 xref: PMID:23250205 xref: PMID:23318641 xref: PMID:24063805 xref: PMID:24922054 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25493551 xref: PMID:25772472 xref: PMID:26017970 xref: PMID:26618653 xref: PMID:27068018 xref: PMID:27606067 xref: PMID:27612384 xref: PMID:27800171 xref: PMID:28137894 xref: PMID:28216315 xref: PMID:28245923 xref: PMID:28495872 xref: PMID:28976975 xref: PMID:29547123 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:30143032 xref: PMID:30399335 xref: PMID:30471994 xref: PMID:30485821 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000099 ! neuron relationship: develops_from PLANA:0000095 ! trail cell relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0000036 ! eye relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4796 [Term] id: PLANA:0000018 name: Category 4 cell namespace: Planarian_Anatomy def: "Post-mitotic, mesenchymally and epidermally located progenitors downstream of the Category 3 cells." [] xref: PMID:18786419 xref: PMID:22439894 xref: PMID:25017721 xref: PMID:26457503 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: PLANA:0000015 ! non ciliated epithelial cell is_a: PLANA:0000033 ! epidermal progenitor cell is_a: PLANA:0002032 ! epidermal cell relationship: develops_from PLANA:0000035 ! Category 3 cell relationship: existence_starts_during_or_after PLANA:0000005 ! Stage 5 relationship: part_of PLANA:0000054 ! dorsal region of the epidermis relationship: part_of PLANA:0002063 ! non-ciliated epidermis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4464 [Term] id: PLANA:0000019 name: muscle progenitor cell namespace: Planarian_Anatomy def: "Progenitor neoblasts implicated in the maintenance and regeneration of muscle fibers." [] xref: PMID:25017721 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:30471994 is_a: PLANA:0000120 ! progenitor cell relationship: part_of PLANA:0000428 ! musculature system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4703 [Term] id: PLANA:0000020 name: protonephridia namespace: Planarian_Anatomy def: "Excretory organs consisting of flame cells, proximal tubules, and distal tubules connected to a mesenchymal collecting duct." [] synonym: "excretory organ" EXACT [] synonym: "nephridia" EXACT [] synonym: "osmoregulatory duct" EXACT [] synonym: "protonephridial tubule" EXACT [] xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:19852954 xref: PMID:19933103 xref: PMID:21828097 xref: PMID:21937596 xref: PMID:22479207 xref: PMID:23318635 xref: PMID:23318641 xref: PMID:23954785 xref: PMID:24063805 xref: PMID:24523458 xref: PMID:24737865 xref: PMID:24992682 xref: PMID:25017721 xref: PMID:25254346 xref: PMID:26057828 xref: PMID:26457503 xref: PMID:26651295 xref: PMID:26711341 xref: PMID:27068018 xref: PMID:27150006 xref: PMID:27501047 xref: PMID:27551436 xref: PMID:27612384 xref: PMID:28245923 xref: PMID:28292427 xref: PMID:28807897 xref: PMID:29100657 xref: PMID:29158443 xref: PMID:29674431 xref: PMID:29674432 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000431 ! organ relationship: develops_from PLANA:0000011 ! protonephridial progenitor cell relationship: part_of PLANA:0000088 ! renal system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/protonephridia.png {comment="http://purl.obolibrary.org/obo/Depicted by field contains a whole-mount acetylated tubulin (AcTub) staining. Scale bars_ 500 um. Inset to right shows depth-coded projection of AcTub staining. Superficial structures are in blue and deeper structures are in red. Scale bars: 50 um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4836 [Term] id: PLANA:0000021 name: biotype namespace: Planarian_Anatomy def: "Organisms sharing a specified genotype or karyotype." [] property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4449 [Term] id: PLANA:0000022 name: Category 5 cell namespace: Planarian_Anatomy def: "Post-mitotic, ciliated epidermal cells." [] xref: PMID:25017721 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000106 ! ciliated epithelial cell is_a: PLANA:0002032 ! epidermal cell relationship: develops_from PLANA:0000018 ! Category 4 cell relationship: existence_starts_during_or_after PLANA:0000006 ! Stage 6 relationship: part_of PLANA:0000054 ! dorsal region of the epidermis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4465 [Term] id: PLANA:0000023 name: embryonic pharynx namespace: Planarian_Anatomy def: "An innervated, muscular pump that ingests yolk cells into the gut cavity. The embryonic pharynx is an extraembryonic tissue that forms during Stage 2, functions during Stages 3-5, and degenerates during Stages 6-7." [] synonym: "temporary embryonic pharynx" EXACT [] xref: ISBN:9780070316607 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0002120 ! extraembryonic organ relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000058 ! embryonic digestive system relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/temporaryembryonicpharynx.gif {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 5 embryo that zooms in on the embryonic pharynx."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4552 [Term] id: PLANA:0000024 name: Smed asexual biotype namespace: Planarian_Anatomy def: "Asexual animal strains that reproduce solely through fission followed by whole body regeneration. Asexual Smed are stable diploids that harbor a chromosome translocation, making them karyotypically distinct from sexual Smed." [] synonym: "asexual" EXACT [] synonym: "asexual adult" EXACT [] synonym: "asexual biotype" EXACT [] xref: PMID:11972158 xref: PMID:28812561 is_a: PLANA:0000021 ! biotype property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/asexualadult.png {comment="Image is an scanning electron micrograph of the dorsal side of an entire animal. This is an adult asexual Schmidtea mediterranea. Anterior is to the right and posterior is to the left. Scale bar is 500um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4880 [Term] id: PLANA:0000025 name: nervous system namespace: Planarian_Anatomy def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organisms, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [] synonym: "nerve system" EXACT [] xref: ISBN:9780070316607 xref: PMID:16033796 xref: PMID:16311336 xref: PMID:17251262 xref: PMID:18202849 xref: PMID:19048075 xref: PMID:19211673 xref: PMID:19247960 xref: PMID:20223763 xref: PMID:20707997 xref: PMID:20967238 xref: PMID:21806978 xref: PMID:22339734 xref: PMID:22427692 xref: PMID:22445864 xref: PMID:22549959 xref: PMID:22696458 xref: PMID:23079596 xref: PMID:23250205 xref: PMID:23297191 xref: PMID:23318641 xref: PMID:23903188 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24737865 xref: PMID:24950970 xref: PMID:25254346 xref: PMID:25278423 xref: PMID:25725068 xref: PMID:26062938 xref: PMID:26114597 xref: PMID:26556349 xref: PMID:27013241 xref: PMID:27068018 xref: PMID:27163480 xref: PMID:27501047 xref: PMID:27523733 xref: PMID:27551436 xref: PMID:27612384 xref: PMID:27864883 xref: PMID:28292427 xref: PMID:29357350 xref: PMID:29557542 xref: PMID:29674431 xref: PMID:30399335 xref: UBERON:0001016 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4709 [Term] id: PLANA:0000026 name: gut namespace: Planarian_Anatomy def: "The planarian triclad gut contains a central anterior gut branch connected to two posterior gut branches arranged around the pharynx. Secondary gut branches extend laterally from the primary gut branches, while tertiary gut branches extend from the secondary branches. Food and waste enter and exit the gut through the pharynx." [] synonym: "adult gut" EXACT [] synonym: "blind gut" EXACT [] synonym: "definitive gut" EXACT [] synonym: "digestive tract" EXACT [] synonym: "gastrovascular digestive tract" EXACT [] synonym: "gastrovascular tract" EXACT [] synonym: "gut" EXACT [] synonym: "intestinal tract" EXACT [] synonym: "intestine" EXACT [] synonym: "three-branched gut" EXACT [] synonym: "triclad gut" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:17553481 xref: PMID:17942485 xref: PMID:18063757 xref: PMID:18287199 xref: PMID:19174194 xref: PMID:19247960 xref: PMID:19933103 xref: PMID:20707997 xref: PMID:20865784 xref: PMID:20967238 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21356107 xref: PMID:21458439 xref: PMID:21566185 xref: PMID:21566195 xref: PMID:21664348 xref: PMID:21806978 xref: PMID:21828097 xref: PMID:22411224 xref: PMID:22439894 xref: PMID:22451003 xref: PMID:22899852 xref: PMID:23079596 xref: PMID:23235145 xref: PMID:23250205 xref: PMID:23318635 xref: PMID:23318641 xref: PMID:23405188 xref: PMID:23903188 xref: PMID:23954785 xref: PMID:24040508 xref: PMID:24063805 xref: PMID:24120894 xref: PMID:24173799 xref: PMID:24238224 xref: PMID:24415944 xref: PMID:24737865 xref: PMID:24950970 xref: PMID:24992682 xref: PMID:25017721 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25558068 xref: PMID:25956527 xref: PMID:26062938 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26556349 xref: PMID:26651295 xref: PMID:27034770 xref: PMID:27063937 xref: PMID:27074666 xref: PMID:27122174 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27240733 xref: PMID:27441386 xref: PMID:27501047 xref: PMID:27542689 xref: PMID:27551436 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:27864883 xref: PMID:28072387 xref: PMID:28216315 xref: PMID:28245923 xref: PMID:28287248 xref: PMID:28292427 xref: PMID:28461239 xref: PMID:28686611 xref: PMID:28807897 xref: PMID:29100657 xref: PMID:29158443 xref: PMID:29547123 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:29906446 xref: PMID:30143032 xref: PMID:30194301 xref: PMID:30282036 xref: PMID:30297872 xref: PMID:30383829 xref: PMID:30471994 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000431 ! organ relationship: develops_from PLANA:0000039 ! gamma neoblast relationship: existence_starts_during_or_after PLANA:0000005 ! Stage 5 relationship: part_of PLANA:0000049 ! digestive system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4632 [Term] id: PLANA:0000027 name: Smed sexual biotype namespace: Planarian_Anatomy def: "Strains of cross-fertilizing hemaphrodites that reproduce sexually and do not undergo fission. After mating, each parent lays an egg capsule containing one or more embryos. Sexual Smed are stable diploids." [] synonym: "hermaphroditic biotype" EXACT [] synonym: "sexual" EXACT [] synonym: "sexual hermaphrodite" EXACT [] xref: PMID:11972158 xref: PMID:28812561 is_a: PLANA:0000021 ! biotype property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/smedsexualbiotype.png {comment="Depicted by field contains light micrscope image of asexual and sexual biotypes of Schmidtea meditteranea with their respective karyotypes. Note that the asexual bioptype has a chromosome inversion compared to the sexual."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4881 [Term] id: PLANA:0000028 name: Category 2 cell namespace: Planarian_Anatomy def: "Post-mitotic, mesenchymally located epidermal progenitors downstream of the zeta neoblasts." [] synonym: "Category 2 gene expressing cell" EXACT [] synonym: "early division progeny" EXACT [] synonym: "early epidermal progenitor" EXACT [] synonym: "early neoblast progeny" EXACT [] synonym: "early post-mitotic progeny" EXACT [] synonym: "early progeny" EXACT [] synonym: "NB.21.11e expressing cell" EXACT [] synonym: "prog-1+ epidermal progenitor cell" EXACT [] synonym: "Smed-NB.21.11e+ cell" EXACT [] xref: PMID:18786419 xref: PMID:20040488 xref: PMID:21894189 xref: PMID:22385657 xref: PMID:22427692 xref: PMID:22439894 xref: PMID:22899852 xref: PMID:23318635 xref: PMID:23629965 xref: PMID:24063805 xref: PMID:24173799 xref: PMID:24367277 xref: PMID:25017721 xref: PMID:26114597 xref: PMID:26651295 xref: PMID:27013241 xref: PMID:27068018 xref: PMID:27542689 xref: PMID:28072387 xref: PMID:29674431 is_a: BFO:0000040 ! material entity is_a: PLANA:0000033 ! epidermal progenitor cell is_a: PLANA:0002095 ! somatic cell relationship: develops_from PLANA:0000014 ! zeta neoblast relationship: existence_starts_during_or_after PLANA:0000005 ! Stage 5 relationship: part_of PLANA:0004529 ! integumental system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4462 [Term] id: PLANA:0000029 name: primitive ectoderm namespace: Planarian_Anatomy def: "A single cell layer of extraembryonic, post-mitotic ectodermal cells bounding the embryo. The primitive ectoderm forms during Stage 2 and is thought to degenerate as the definitive epidermis forms during Stages 5-7." [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000001.md xref: OCLC:20423827 xref: OCLC:464776945 xref: OCLC:82522822 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0002120 ! extraembryonic organ relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: RO:0001018 PLANA:0000041 ! contained in aboral hemisphere relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4822 [Term] id: PLANA:0000030 name: midline namespace: Planarian_Anatomy def: "The median line/ plane of bilateral symmetry along the anteroposterior axis." [] is_a: PLANA:0000102 ! anatomical region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4696 [Term] id: PLANA:0000031 name: pigment cup cell namespace: Planarian_Anatomy def: "Non-neuronal, pigmented cells arrayed along the proximal side of the optic cup." [] synonym: "eye pigment cell" EXACT [] synonym: "eye pigment cup cell" EXACT [] synonym: "eye pigment producing cell" EXACT [] synonym: "eye pigmented cell" EXACT [] synonym: "melanin pigment cell" EXACT [] synonym: "optic cup cell" EXACT [] synonym: "photoceptor pigmented cell" EXACT [] synonym: "pigment cell" EXACT [] xref: PMID:17251262 xref: PMID:17390146 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:20967238 xref: PMID:21282632 xref: PMID:21458439 xref: PMID:21852957 xref: PMID:22339734 xref: PMID:22445864 xref: PMID:22884275 xref: PMID:23250205 xref: PMID:23318641 xref: PMID:24063805 xref: PMID:25254346 xref: PMID:25493551 xref: PMID:26017970 xref: PMID:27122174 xref: PMID:27551436 xref: PMID:27606067 xref: PMID:28137894 xref: PMID:28245923 xref: PMID:28287248 xref: PMID:28495872 xref: PMID:28976975 xref: PMID:29158443 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:30471994 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000561 ! neuron associated cell (sensu Nematoda and Protostomia) relationship: develops_from PLANA:0000095 ! trail cell relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0000075 ! optic cup relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4798 [Term] id: PLANA:0000032 name: dorsal midline namespace: Planarian_Anatomy def: "The median line/plane of bilateral symmetry along the anteroposterior axis on the dorsal surface of the animal." [] synonym: "dorsal region of midline" EXACT [] is_a: PLANA:0000038 ! ventral midline intersection_of: has_component BSPO:0000079 ! dorsal region intersection_of: part_of PLANA:0000030 ! midline relationship: has_component BSPO:0000079 ! dorsal region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000033 name: epidermal progenitor cell namespace: Planarian_Anatomy def: "Mitotically active zeta neoblasts and their post-mitotic descendants which undergo progressive differentiation and outward directed movement through the mesenchyme prior to incorporation into the epidermis, where terminal differentiation occurs." [] synonym: "epithelial progenitor" EXACT [] xref: PMID:27150006 xref: PMID:27606067 xref: PMID:29674432 xref: PMID:30282036 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000034 name: epidermis namespace: Planarian_Anatomy def: "A single cell layer of post-mitotic epithelial cells containing ciliated and non-ciliated cell types forming the exterior surface of the animal." [] comment: At present, this definition does not apply to epithelial structures other than the dorsal and ventral epidermis (i.e., the pharyngeal epithelium). synonym: "definitive epidermis" EXACT [] synonym: "epidermal layer" EXACT [] synonym: "epidermis" EXACT [] synonym: "epithelium" EXACT [] synonym: "mature epidermis" EXACT [] synonym: "tegument" EXACT [] xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:15866156 xref: PMID:16311336 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:19247960 xref: PMID:19852954 xref: PMID:20215344 xref: PMID:20511647 xref: PMID:20599901 xref: PMID:20865784 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21295483 xref: PMID:22252539 xref: PMID:22549959 xref: PMID:23235145 xref: PMID:23297191 xref: PMID:23954785 xref: PMID:24120894 xref: PMID:24173799 xref: PMID:24922054 xref: PMID:24950970 xref: PMID:25558068 xref: PMID:25772472 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26651295 xref: PMID:26711341 xref: PMID:27034770 xref: PMID:27074666 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27240733 xref: PMID:27501047 xref: PMID:27612384 xref: PMID:28137894 xref: PMID:28216315 xref: PMID:28245923 xref: PMID:28292427 xref: PMID:28686611 xref: PMID:28757112 xref: PMID:28976975 xref: PMID:29100657 xref: PMID:29158443 xref: PMID:29273738 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:29906446 xref: PMID:30194301 xref: PMID:30282036 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000431 ! organ relationship: develops_from PLANA:0000033 ! epidermal progenitor cell relationship: existence_starts_during_or_after PLANA:0000005 ! Stage 5 relationship: part_of PLANA:0004529 ! integumental system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment="Image is an electron micrograph depicting the dorsal epidermis (arrowheads). Also visible in this micrograph, immediately deep to the epidermis is the basal lamina and beneath that is a photoreceptor. Scale bar is 10 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4569 [Term] id: PLANA:0000035 name: Category 3 cell namespace: Planarian_Anatomy def: "Post-mitotic, mesenchymally located epidermal progenitors downstream of the Category 2 cells." [] synonym: "AGAT-1 expressing cell" EXACT [] synonym: "AGAT1 expressing cell" EXACT [] synonym: "Category 3 gene expressing cell" EXACT [] synonym: "late division progeny" EXACT [] synonym: "late epidermal progenitor" EXACT [] synonym: "late neoblast progeny" EXACT [] synonym: "late postmitotic progeny" EXACT [] synonym: "late progeny" EXACT [] synonym: "Smed-AGAT-1+ cell" EXACT [] xref: PMID:18786419 xref: PMID:20040488 xref: PMID:21894189 xref: PMID:22252539 xref: PMID:22427692 xref: PMID:22439894 xref: PMID:22899852 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23629965 xref: PMID:23954785 xref: PMID:24063805 xref: PMID:24173799 xref: PMID:24367277 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26651295 xref: PMID:27013241 xref: PMID:27068018 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: PLANA:0000033 ! epidermal progenitor cell is_a: PLANA:0002095 ! somatic cell relationship: develops_from PLANA:0000028 ! Category 2 cell relationship: existence_starts_during_or_after PLANA:0000005 ! Stage 5 relationship: part_of PLANA:0004529 ! integumental system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/epidermis.png {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4463 [Term] id: PLANA:0000036 name: eye namespace: Planarian_Anatomy def: "An organ that detects light." [] comment: Depicted by field contains hematoxylin and eosin staining section of a asexual adult animal. The eyes are indicated by arrows. Scale bar = 250um synonym: "cerebral eye" EXACT [] synonym: "eye spot" EXACT [] synonym: "eye-spot" EXACT [] synonym: "eyespot" EXACT [] synonym: "ocelli" EXACT [] synonym: "photoreceptor" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:15866156 xref: PMID:15972844 xref: PMID:16311336 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:17942485 xref: PMID:18063755 xref: PMID:18063757 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:18456843 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:19174194 xref: PMID:19211673 xref: PMID:19247960 xref: PMID:19766622 xref: PMID:19805089 xref: PMID:19852954 xref: PMID:20040488 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:20422023 xref: PMID:20599901 xref: PMID:20707997 xref: PMID:20865784 xref: PMID:20967238 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21295481 xref: PMID:21295483 xref: PMID:21356107 xref: PMID:21458439 xref: PMID:21566185 xref: PMID:21566195 xref: PMID:21747960 xref: PMID:21806978 xref: PMID:21828097 xref: PMID:21852957 xref: PMID:21894189 xref: PMID:21937596 xref: PMID:22125640 xref: PMID:22318224 xref: PMID:22339734 xref: PMID:22385657 xref: PMID:22411224 xref: PMID:22439894 xref: PMID:22445864 xref: PMID:22479207 xref: PMID:22549959 xref: PMID:22884275 xref: PMID:22899852 xref: PMID:23235145 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23318641 xref: PMID:23405188 xref: PMID:23629965 xref: PMID:23903188 xref: PMID:24063805 xref: PMID:24120894 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24238224 xref: PMID:24415944 xref: PMID:24704339 xref: PMID:24737865 xref: PMID:24922054 xref: PMID:24950970 xref: PMID:24992682 xref: PMID:25017721 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25493551 xref: PMID:25558068 xref: PMID:25725068 xref: PMID:25772472 xref: PMID:25956527 xref: PMID:26017970 xref: PMID:26062938 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26525673 xref: PMID:26556349 xref: PMID:26618653 xref: PMID:26711341 xref: PMID:26884331 xref: PMID:27034770 xref: PMID:27063937 xref: PMID:27150006 xref: PMID:27240733 xref: PMID:27542689 xref: PMID:27551436 xref: PMID:27606067 xref: PMID:27654173 xref: PMID:27800171 xref: PMID:28171748 xref: PMID:28216315 xref: PMID:28287248 xref: PMID:28292427 xref: PMID:28495872 xref: PMID:28686611 xref: PMID:28893948 xref: PMID:28976975 xref: PMID:29100657 xref: PMID:29158443 xref: PMID:29273738 xref: PMID:29291974 xref: PMID:29291981 xref: PMID:29357350 xref: PMID:29547123 xref: PMID:29674431 xref: PMID:30237141 xref: PMID:30282036 xref: PMID:30297872 xref: PMID:30383829 xref: PMID:30485821 xref: PMID:30962434 xref: UBERON:0000970 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000431 ! organ relationship: develops_from PLANA:0000095 ! trail cell relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0000124 ! visual system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/eye.png {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4584 [Term] id: PLANA:0000037 name: obsolete definitive tissue comment: we will move forward using "tissue" instead. We have not listed anything as a regenerating or developing tissue, so this seems unnecessary is_obsolete: true replaced_by: PLANA:0000113 [Term] id: PLANA:0000038 name: ventral midline namespace: Planarian_Anatomy def: "The median line/ plane of bilateral symmetry along the anteroposterior axis on the ventral surface of the animal." [] synonym: "ventral region of midline" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000084 ! ventral region intersection_of: part_of PLANA:0000030 ! midline relationship: has_component BSPO:0000084 ! ventral region relationship: part_of PLANA:0000030 ! midline property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000039 name: gamma neoblast namespace: Planarian_Anatomy def: "An abundant neoblast subclass, exhibiting enriched expression of gata456a, hnf4, prox-1 and nkx2.2, implicated in maintenance and regeneration of the definitive gut." [] synonym: "gamma" EXACT [] synonym: "gamma class neoblast" EXACT [] synonym: "gamma-neoblast" EXACT [] synonym: "gut progenitor cell" EXACT [] xref: PMID:25017721 xref: PMID:26651295 xref: PMID:27013241 xref: PMID:27150006 xref: PMID:27542689 xref: PMID:28287248 xref: PMID:28757112 xref: PMID:28807897 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:29906446 is_a: PLANA:0000429 ! neoblast relationship: part_of PLANA:0000049 ! digestive system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4613 [Term] id: PLANA:0000040 name: obsolete Schmidtea mediterranea developmental stage comment: this term is not needed. All previous children of this term (Stage 1, Sage 2, etc) are now children of GO life cycle stage or zygote stage is_obsolete: true [Term] id: PLANA:0000041 name: aboral hemisphere namespace: Planarian_Anatomy def: "Stage 3-5 embryo hemisphere centered around the pole opposite the embryonic pharynx." [] xref: PMID:28072387 is_a: PLANA:0000423 ! embryonic subdivision relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4407 [Term] id: PLANA:0000042 name: anterior primary gut branch namespace: Planarian_Anatomy def: "The single, central gut branch of the triclad gut anterior to the pharynx." [] xref: PMID:21664348 is_a: BFO:0000040 ! material entity is_a: PLANA:0002086 ! primary gut branch relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/anteriorprimarygutbranch.png {comment="Depicted by field contains hematoxylin and eosin staining section of a asexual adult animal. Anterior primary gut branch indicated by arrows. Scale bar = 250um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4435 [Term] id: PLANA:0000043 name: dorsal ventral margin of the whole animal namespace: Planarian_Anatomy def: "Region along the edge of the animal where the dorsal and ventral surfaces meet." [] synonym: "body edge" EXACT [] synonym: "body margin" EXACT [] synonym: "body periphery" EXACT [] synonym: "D/V boundary" EXACT [] synonym: "dorsal ventral boundary" EXACT [] synonym: "dorsal-ventral boundary" EXACT [] synonym: "dorsal/ventral compartment boundary of whole organism" EXACT [] synonym: "dorsoventral margin" EXACT [] synonym: "DV border" EXACT [] synonym: "DV boundary" EXACT [] synonym: "DV domain" EXACT [] synonym: "DV margin" EXACT [] synonym: "edge" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000094 ! dorsal/ventral compartment boundary intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000094 ! dorsal/ventral compartment boundary relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000044 name: cephalic ganglia namespace: Planarian_Anatomy def: "The planarian brain, consisting of two bilaterally symmetric lobes occupying a ventral position in the head." [] synonym: "bi-lobed brain" EXACT [] synonym: "bi-lobed cephalic ganglia" EXACT [] synonym: "brain" EXACT [] synonym: "cerebral ganglia" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:15866156 xref: PMID:16033796 xref: PMID:16344473 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17376870 xref: PMID:17553481 xref: PMID:17670787 xref: PMID:17905225 xref: PMID:17942485 xref: PMID:17999079 xref: PMID:18063755 xref: PMID:18063757 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:19048075 xref: PMID:19174194 xref: PMID:19211673 xref: PMID:19247960 xref: PMID:19766622 xref: PMID:20215344 xref: PMID:20422023 xref: PMID:20844018 xref: PMID:20967238 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21295481 xref: PMID:21458439 xref: PMID:21566195 xref: PMID:21806978 xref: PMID:22074376 xref: PMID:22125640 xref: PMID:22339734 xref: PMID:22411224 xref: PMID:22445864 xref: PMID:22451003 xref: PMID:22549959 xref: PMID:23235145 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23318641 xref: PMID:23405188 xref: PMID:23652002 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24238224 xref: PMID:24415944 xref: PMID:24950970 xref: PMID:25254346 xref: PMID:25278423 xref: PMID:25356635 xref: PMID:25404302 xref: PMID:25725068 xref: PMID:25772472 xref: PMID:25956527 xref: PMID:26017970 xref: PMID:26884331 xref: PMID:27013241 xref: PMID:27074666 xref: PMID:27163480 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:27800171 xref: PMID:28072387 xref: PMID:28126842 xref: PMID:28216315 xref: PMID:28287248 xref: PMID:29291974 xref: PMID:29291981 xref: PMID:29547123 xref: PMID:29674431 xref: PMID:30194301 xref: PMID:30237141 is_a: BFO:0000040 ! material entity is_a: PLANA:0000431 ! organ relationship: existence_starts_during_or_after PLANA:0000006 ! Stage 6 relationship: part_of PLANA:0000103 ! central nervous system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4477 [Term] id: PLANA:0000045 name: circular muscle cell namespace: Planarian_Anatomy def: "Body wall muscle fibers arrayed around the dorsoventral axis. Upon regeneration, these are thought to be produced de novo in the blastema." [] synonym: "circular muscle fiber" EXACT [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000005.md xref: PMID:26904543 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000101 ! muscle cell relationship: develops_from PLANA:0000130 ! circular muscle progenitor cell relationship: part_of PLANA:0000240 ! body wall musculature relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/circularmusclecell.png {comment="Image is an electron micrograph depicting the body wall musculature beneath the dorsal epidermis. The first layer of muscle cells beneath the basal lamina (BL), circular muscle, have been colored and labeled with arrowheads. Circular muscle = magenta; longitudinal muscle = green; diagonal muscle = red. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4497 [Term] id: PLANA:0000046 name: clonogenic neoblast namespace: Planarian_Anatomy def: "Pluripotent piwi-1+ stem cells that self-renew, form expanding colonies and produce differentiating daughters that contribute to multiple organ systems. cNeoblasts are predicted to be broadly distributed across the anteroposterior axis of the adult worm." [] synonym: "adult pluripotent stem cell" EXACT [] synonym: "clonogenic stem cell" EXACT [] synonym: "cNeoblast" EXACT [] synonym: "pluripotent stem cell" EXACT [] xref: PMID:16344473 xref: PMID:19247960 xref: PMID:20215344 xref: PMID:21566185 xref: PMID:21852957 xref: PMID:21937596 xref: PMID:22318224 xref: PMID:22385657 xref: PMID:22411224 xref: PMID:22543868 xref: PMID:22549959 xref: PMID:22884275 xref: PMID:22899852 xref: PMID:23079596 xref: PMID:23297191 xref: PMID:23318641 xref: PMID:23652002 xref: PMID:23954785 xref: PMID:24040508 xref: PMID:24120894 xref: PMID:24173799 xref: PMID:25017721 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:26711341 xref: PMID:27063937 xref: PMID:27074666 xref: PMID:27149082 xref: PMID:27150006 xref: PMID:27502555 xref: PMID:27523733 xref: PMID:27551436 xref: PMID:28434803 xref: PMID:29357350 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:29906446 xref: PMID:30962434 is_a: PLANA:0000429 ! neoblast is_a: PLANA:0002095 ! somatic cell relationship: existence_starts_during_or_after PLANA:0000006 ! Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4499 [Term] id: PLANA:0000047 name: collecting duct namespace: Planarian_Anatomy def: "Non-ciliated tubules associated with the distal tubules, which cross the basement membrane and terminate in the dorsal epidermis." [] synonym: "collection duct" EXACT [] xref: PMID:26057828 xref: PMID:27068018 xref: PMID:29674431 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: adjacent_to PLANA:0000053 ! distal tubule relationship: part_of PLANA:0000088 ! renal system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/collectingduct.png {comment="Image is an electron micrograph depicting a collecting duct (arrowheads) passing through the basal lamina (BL). Dorsal is up and the scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4500 [Term] id: PLANA:0000048 name: diagonal muscle cell namespace: Planarian_Anatomy def: "Body wall muscle fibers arrayed diagonally along the anteroposterior axis." [] synonym: "diagonal fiber" EXACT [] synonym: "diagonal muscle" EXACT [] synonym: "diagonal muscle fiber" EXACT [] xref: ISBN:9780070316607 xref: PMID:23903188 xref: PMID:26904543 xref: PMID:27068018 xref: PMID:28461239 xref: PMID:28807897 xref: PMID:30471994 is_a: BFO:0000040 ! material entity is_a: PLANA:0000101 ! muscle cell relationship: part_of PLANA:0000240 ! body wall musculature relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/diagonalmusclecell.png {comment="Image is an electron micrograph depicting the body wall musculature beneath the dorsal epidermis. The third layer of cells beneath the basement membrane, diagonal muscle cells, have been colored and labeled with arrowheads. Circular muscle = magenta; longitudinal muscle = green; diagonal muscle = red. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4517 [Term] id: PLANA:0000049 name: digestive system namespace: Planarian_Anatomy def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [] synonym: "gastrointestinal system" EXACT [] synonym: "gastrovascular system" EXACT [] xref: ISBN:9780070316607 xref: PMID:15866156 xref: PMID:16311336 xref: PMID:16344473 xref: PMID:17390146 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:18063757 xref: PMID:18287199 xref: PMID:19048075 xref: PMID:19247960 xref: PMID:19766622 xref: PMID:19933103 xref: PMID:20040488 xref: PMID:20215344 xref: PMID:20707997 xref: PMID:21356107 xref: PMID:21664348 xref: PMID:21806978 xref: PMID:22451003 xref: PMID:22479207 xref: PMID:23079596 xref: PMID:24737865 xref: PMID:24922054 xref: PMID:25254346 xref: PMID:25558068 xref: PMID:26556349 xref: PMID:27068018 xref: PMID:27501047 xref: PMID:29357350 xref: UBERON:0001007 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4519 [Term] id: PLANA:0000051 name: obsolete direct development comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000052 name: obsolete dispersed cleavage comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000053 name: distal tubule namespace: Planarian_Anatomy def: "Sinusoidal, non-ciliated tubules connected to proximal tubules within the parenchyma. Tubules are formed via intercellular junctions between two epithelial cells." [] xref: PMID:21828097 xref: PMID:27068018 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000113 ! tissue relationship: adjacent_to PLANA:0000047 ! collecting duct relationship: develops_from PLANA:0000011 ! protonephridial progenitor cell relationship: part_of PLANA:0000020 ! protonephridia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/distaltubule.png {comment="Depicted by field contains a diagram representing the protonephrida unit (top) as well as a 3D rendering of confocal data depicting the same. In the diagram, terminal flame cells and their corresponding cilia are in blues, the proximal tubule is in reds, the distal tubule is in greens while thecollecting duct is in purple. In the 3D rendering below the cilia (AcTub) are in blue, portions of the proximal tubule (slc6a-13) are in red while the distal tubule (slc6a-12) is in green."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4524 [Term] id: PLANA:0000054 name: dorsal region of the epidermis namespace: Planarian_Anatomy def: "Single cell layer of dorsal, post-mitotic, epithelial cells containing the dorsal stripe." [] synonym: "dorsal epithelium" EXACT [] synonym: "dorsal region of epidermis" EXACT [] is_a: PLANA:0000096 ! ventral epidermis intersection_of: has_component BSPO:0000079 ! dorsal region intersection_of: part_of PLANA:0000034 ! epidermis relationship: has_component BSPO:0000079 ! dorsal region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000055 name: dorsal stripe namespace: Planarian_Anatomy def: "Ciliated epithelial cells along the dorsal midline." [] synonym: "racing stripe" EXACT [] xref: PMID:17553481 is_a: BFO:0000040 ! material entity is_a: PLANA:0002023 ! ciliated epithelium relationship: part_of PLANA:0000054 ! dorsal region of the epidermis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/dorsalstripe.png {comment="Image is an electron micrograph showing the dorsal side of the head of an adult worm. Arrowheads mark where the ciliated cells of the dorsal stripe can be seen. Anterior is up and scale bar is 100um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4533 [Term] id: PLANA:0000056 name: ectolecithal embryo namespace: Planarian_Anatomy def: "Turbellarian (freshwater flatworm) embryos that undergo a modified form of cleavage due to separation of oocyte and yolk. Yolk is not contained within oocytes, and is produced by somatic vitellogenic gland cells." [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000002.md xref: PMID:22074376 xref: PMID:27149082 is_a: PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4539 [Term] id: PLANA:0000057 name: obsolete embryonic cleavage comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000058 name: embryonic digestive system namespace: Planarian_Anatomy def: "A cryptic digestive system in Stage 3-6 embryos comprised of temporary embryonic cell types and organs, including the embryonic pharynx and primitive gut cells. Embryonic gut cells, likely produced from blastomeres, form a phagocytic tissue layer surrounding the inner gut cavity during Stages 4-6. It is not known whether the embryonic gut is temporary embryonic tissue or a definitive tissue. For convenience, the embryonic gut is currently designated as an extraembryonic structure because cell type specific markers for the embryonic gut do not stain the definitive gut in hatchlings or adult animals." [] xref: PMID:28072387 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000063 ! extraembryonic structure relationship: existence_ends_during_or_before PLANA:0000007 ! Stage 7 relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4547 [Term] id: PLANA:0000059 name: embryonic gut cell namespace: Planarian_Anatomy def: "Dispersed, phagocytic gut cells that appear during Stage 4 and ultimately generate a honeycomb-like lattice surrounding the central gut cavity in Stage 5 embryos. Early embryonic gut cell specific transcripts are expressed from Stage 4-6, and are downregulated during Stage 7." [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0004518 ! extraembryonic cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000004 ! Stage 4 relationship: part_of PLANA:0002031 ! embryonic gut relationship: RO:0001018 PLANA:0000041 ! contained in aboral hemisphere relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4550 [Term] id: PLANA:0000060 name: embryonic wall namespace: Planarian_Anatomy def: "The parenchymal space between the gut cavity and the primitive ectoderm containing undifferentiated blastomeres in Stage 3-5 embryos." [] xref: OCLC:16809160 xref: PMID:12888018 xref: PMID:28072387 is_a: PLANA:0000423 ! embryonic subdivision relationship: existence_ends_during_or_before PLANA:0000005 ! Stage 5 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/embryonicwall.png {comment="Depicted by field contains hematoxylin and eosin staining section of a stage 5 embryo with anatomical feature noted with black indicators."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4561 [Term] id: PLANA:0000061 name: enteric musculature namespace: Planarian_Anatomy def: "Visceral muscle surrounding the gut." [] synonym: "enteric muscle" EXACT [] synonym: "intestinal muscle" EXACT [] xref: PMID:21664348 xref: PMID:22411224 xref: PMID:23079596 xref: PMID:26904543 xref: PMID:30471994 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: PLANA:0000013 ! visceral musculature relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0000049 ! digestive system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/entericmusculature.png {comment="Image is an electron micrograph depicting the enteric musculature (arrowheads) surrounding the gut, which extends across the top of the image. These cells are very small compared to the layer of medial muscle underneath them. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4564 [Term] id: PLANA:0000062 name: esophagus namespace: Planarian_Anatomy def: "Attachment between the triclad gut and the proximal end of the pharynx." [] synonym: "gut pharynx intersection" EXACT [] synonym: "pharynx root" EXACT [] synonym: "root of pharynx" EXACT [] xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:18063757 xref: PMID:20707997 xref: PMID:21806978 xref: PMID:24737865 xref: PMID:27063937 xref: PMID:29674431 xref: PMID:30485821 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4574 [Term] id: PLANA:0000063 name: extraembryonic structure namespace: Planarian_Anatomy def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [] xref: UBERON:0000478 is_a: UBERON:0005423 ! developing anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4583 [Term] id: PLANA:0000064 name: flame bulb namespace: Planarian_Anatomy def: "Terminal structure of protonephridia unit; consists of flame cells." [] xref: PMID:21828097 xref: PMID:26057828 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000113 ! tissue relationship: develops_from PLANA:0000011 ! protonephridial progenitor cell relationship: part_of PLANA:0000020 ! protonephridia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/flamebulb.png {comment="Image is an electron micrograph depicting a flame cell (outlined), which is a part of the flame bulb. \"N\" marks this cell's nucleus and the cilia are noted by an arrowhead. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4594 [Term] id: PLANA:0000065 name: flame cell namespace: Planarian_Anatomy def: "Terminal structure of the protonephridia unit, capping the proximal tubules. Flame cells are defined by the filtration weir‚ or filtration diaphragm, which consists of closely apposed strands of cytoplasm surrounding a central cilia bundle, and by numerous microvilli between weir and cilia. Positive for acetyated tubulin." [] xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:17670787 xref: PMID:19247960 xref: PMID:19852954 xref: PMID:21828097 xref: PMID:21937596 xref: PMID:24523458 xref: PMID:26057828 xref: PMID:26711341 xref: PMID:27068018 xref: PMID:27542689 xref: PMID:29674431 xref: PMID:29674432 is_a: BFO:0000040 ! material entity is_a: PLANA:0000119 ! terminally differentiated cell relationship: adjacent_to PLANA:0000087 ! proximal tubule relationship: part_of PLANA:0000064 ! flame bulb relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/flamecell.png {comment="Image is an electron micrograph depicting a flame cell (outlined), which is a part of the flame bulb. \"N\" marks this cell's nucleus and the cilia are noted by an arrowhead. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4595 [Term] id: PLANA:0000066 name: gastrodermis namespace: Planarian_Anatomy def: "The single cell layer columnar epithelial lining of the intestine. The gastrodermis is surrounded by a basal lamina and enteric muscle." [] synonym: "gut epithelia" EXACT [] synonym: "gut epithelium" EXACT [] synonym: "intestinal epithelium" EXACT [] xref: ISBN:9780070316607 xref: PMID:21282632 xref: PMID:21664348 xref: PMID:24120894 xref: PMID:25558068 xref: PMID:27441386 xref: PMID:27501047 xref: PMID:28287248 xref: PMID:30608231 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0002118 ! epithelium relationship: develops_from PLANA:0000039 ! gamma neoblast relationship: part_of PLANA:0000026 ! gut relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4617 [Term] id: PLANA:0000067 name: goblet cell namespace: Planarian_Anatomy def: "Secretory cells that release digestive enzymes into the lumen of the intestine." [] xref: PMID:20865784 xref: PMID:21664348 xref: PMID:23079596 xref: PMID:27501047 xref: PMID:28137894 xref: PMID:28287248 xref: PMID:29674431 xref: PMID:29674432 is_a: BFO:0000040 ! material entity is_a: PLANA:0000105 ! secretory cell relationship: part_of PLANA:0000066 ! gastrodermis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/gobletcell.png {comment="Image is an electron micrograph showing part of the gastrodermis. A goblet cell, a type of gastrodermal cell is labeled with arrowheads. Note the large, dark mucus granules contained in the cell body. The lumen of the gut can be seen on the right side of the image and has been labeled with \"L.\" Scale bar is 1 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4628 [Term] id: PLANA:0000068 name: embryonic gut cavity namespace: Planarian_Anatomy def: "Cavity encompassed by the embryonic digestive tract, prior to formation of the branched defintive gut." [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: UBERON:0002553 ! anatomical cavity relationship: existence_ends_during_or_before PLANA:0000007 ! Stage 7 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: part_of PLANA:0002031 ! embryonic gut relationship: RO:0001018 PLANA:0000041 ! contained in aboral hemisphere relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4549 [Term] id: PLANA:0000069 name: inner longitudinal muscle cell namespace: Planarian_Anatomy def: "Inner most body wall muscle fibers arrayed along the anteroposterior axis. These fibers are thicker than the outer longitudinal muscle fibers. The pattern of these muscles differs along the dorsoventral axis, with the dorsal arrangement converging at the central zone of the anterior pole. The ventral arrangement is more parallel or may diverge slightly as it approaches the ventral pole." [] synonym: "inner longitudinal muscle fiber" EXACT [] synonym: "inner longitudinal muscle layer" EXACT [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000003.md xref: ISBN:9780070316607 xref: PMID:26904543 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000071 ! longitudinal muscle cell relationship: develops_from PLANA:0000134 ! longitudinal muscle progenitor cell relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4638 [Term] id: PLANA:0000070 name: intestinal phagocyte namespace: Planarian_Anatomy def: "Absorptive digestive cells that engulf food particles for intracellular digestion." [] synonym: "enterocyte" EXACT [] synonym: "gut enterocyte" EXACT [] synonym: "gut phagocyte" EXACT [] synonym: "intestinal epithelial cell" EXACT [] xref: PMID:19933103 xref: PMID:21664348 xref: PMID:23079596 xref: PMID:27542689 xref: PMID:28072387 xref: PMID:29674431 xref: PMID:29674432 is_a: BFO:0000040 ! material entity is_a: PLANA:0000119 ! terminally differentiated cell relationship: part_of PLANA:0000066 ! gastrodermis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4643 [Term] id: PLANA:0000071 name: longitudinal muscle cell namespace: Planarian_Anatomy def: "Body wall muscle fibers arrayed along the anteroposterior axis. Upon regeneration, these muscles are thought to be established from truncated pre-existing fibers.Inner most body wall muscle fibers arrayed along the anteroposterior axis. These fibers are thicker than the outer longitudinal muscle fibers. The pattern of these muscles differs along the dorsoventral axis, with the dorsal arrangement converging at the central zone of the anterior pole. The ventral arrangement is more parallel or may diverge slightly as it approaches the ventral pole." [] synonym: "body wall longitudinal fiber" EXACT [] synonym: "BW longitudinal fiber" EXACT [] synonym: "longitudinal fiber" EXACT [] synonym: "longitudinal muscle" EXACT [] synonym: "longitudinal muscle cell" EXACT [] synonym: "longitudinal muscle fiber" EXACT [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000005.md xref: ISBN:9780070316607 xref: PMID:23903188 xref: PMID:26904543 xref: PMID:27551436 xref: PMID:28461239 xref: PMID:28807897 xref: PMID:30471994 is_a: PLANA:0000101 ! muscle cell relationship: part_of PLANA:0000240 ! body wall musculature property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/longitudinalmusclecell.png {comment="Image is an electron micrograph depicting the body wall musculature beneath the dorsal epidermis. The longitudinal muscle cells (arrowheads) sit behind both the circular muscle and the diagonal muscle. Circular muscle = magenta; longitudinal muscle = green; diagonal muscle = red. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4660 [Term] id: PLANA:0000072 name: mouth namespace: Planarian_Anatomy def: "The sole point of entry and exit for the Triclad planarian flatworm gut. The mouth is connected to the pharyngeal pouch to allow for exit and re-entry of the pharynx on the ventral side of the animal. The mouth contains several cell types, including epithelial cells, muscle, and secretory cells." [] synonym: "anus" EXACT [] synonym: "manus" EXACT [] xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:17251262 xref: PMID:17905225 xref: PMID:18287199 xref: PMID:19174194 xref: PMID:19211673 xref: PMID:20707997 xref: PMID:21295481 xref: PMID:21458439 xref: PMID:21806978 xref: PMID:23954785 xref: PMID:26457503 xref: PMID:26556349 xref: PMID:27034770 xref: PMID:27063937 xref: PMID:27074666 xref: PMID:27122174 xref: PMID:28807897 xref: PMID:29674431 xref: PMID:30399335 xref: PMID:30471994 xref: PMID:30485821 is_a: BFO:0000040 ! material entity is_a: PLANA:0000431 ! organ relationship: existence_starts_during_or_after PLANA:0000006 ! Stage 6 relationship: part_of PLANA:0000049 ! digestive system relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/mouth.png {comment="Image is an electron micrograph of the mouth (arrowheads), which is located on the ventral side of the animal. Note the heavily ciliated pharynx that is peeking out. Scale bar is 10um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4698 [Term] id: PLANA:0000074 name: oocyte namespace: Planarian_Anatomy def: "A female germ cell that has entered meiosis." [] synonym: "egg" EXACT [] synonym: "female gamete" EXACT [] synonym: "ovum" EXACT [] xref: CL:0000023 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:27330085 xref: PMID:27501047 xref: PMID:28072387 xref: PMID:28434803 xref: PMID:28812561 is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000122 ! gamete is_a: PLANA:0000229 ! female germ cell relationship: develops_from PLANA:0000239 ! oogonial cell relationship: part_of PLANA:0000204 ! ovary relationship: produced_by PLANA:0000204 ! ovary relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4973 [Term] id: PLANA:0000075 name: optic cup namespace: Planarian_Anatomy def: "A portion of the eye containing pigment cells and dendritic projections from photoreceptor neurons." [] synonym: "eye cup" EXACT [] synonym: "photoreceptor pigment cup" EXACT [] synonym: "photoreceptor pigmentation" EXACT [] synonym: "pigment cup" EXACT [] synonym: "pigmented cell cup" EXACT [] synonym: "pigmented optic cup" EXACT [] xref: ISBN:9780070316607 xref: PMID:15866156 xref: PMID:20707997 xref: PMID:20865784 xref: PMID:21458439 xref: PMID:21828097 xref: PMID:21852957 xref: PMID:22411224 xref: PMID:22427692 xref: PMID:22445864 xref: PMID:22549959 xref: PMID:22884275 xref: PMID:25493551 xref: PMID:26017970 xref: PMID:26618653 xref: PMID:27068018 xref: PMID:27240733 xref: PMID:27542689 xref: PMID:27606067 xref: PMID:27800171 xref: PMID:28495872 xref: PMID:29547123 xref: PMID:30143032 xref: PMID:30194301 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0000036 ! eye relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4736 [Term] id: PLANA:0000076 name: oral hemisphere namespace: Planarian_Anatomy def: "Stage 3-5 embryo hemisphere centered around the embryonic pharynx." [] xref: PMID:28072387 is_a: PLANA:0000423 ! embryonic subdivision relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4739 [Term] id: PLANA:0000078 name: outer longitudinal muscle cell namespace: Planarian_Anatomy def: "Body wall muscle fibers arrayed along the anteroposterior axis. Upon regeneration, these muscles are thought to be established from truncated pre-existing fibers." [] synonym: "outer longitudinal muscle layer" EXACT [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000005.md xref: ISBN:9780070316607 xref: PMID:26904543 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000071 ! longitudinal muscle cell relationship: develops_from PLANA:0000134 ! longitudinal muscle progenitor cell relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4743 [Term] id: PLANA:0000079 name: parenchymal musculature namespace: Planarian_Anatomy def: "Muscles that are present through the mesenchyme, inclusing dorsal-ventral muscles, intestinal muscles and pharynx muscles." [] synonym: "dorsoventral muscle fibers" EXACT [] synonym: "parenchymal muscle" EXACT [] xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: PLANA:0000431 ! organ relationship: part_of PLANA:0000428 ! musculature system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/parenchymalmusculature.png {comment="Image is an electron micrograph of the parenchyma. Three muscle cells have been notated with an arrowhead. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4759 [Term] id: PLANA:0000080 name: peripheral nervous system namespace: Planarian_Anatomy def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [] xref: PMID:20967238 xref: PMID:22339734 xref: PMID:23903188 xref: PMID:26017970 xref: PMID:26884331 xref: PMID:27150006 xref: PMID:27612382 xref: PMID:29674431 xref: UBERON:0000010 is_a: PLANA:0000025 ! nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4762 [Term] id: PLANA:0000081 name: pharynx pouch namespace: Planarian_Anatomy def: "An epithelial structure housing the pharynx, connected to the esophagus and mouth." [] synonym: "pharyngeal pouch" EXACT [] xref: OCLC:16809160 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4788 [Term] id: PLANA:0000082 name: obsolete racing stripe comment: racing stripe is now a synonym of PLANA:0000055 dorsal stripe is_obsolete: true [Term] id: PLANA:0000084 name: posterior primary gut branch namespace: Planarian_Anatomy def: "The primary gut branches of the triclad gut lateral and posterior to the pharynx and pharyngeal pouch." [] synonym: "major posterior gut branch" EXACT [] synonym: "primary posterior intestinal branch" EXACT [] xref: PMID:21664348 xref: PMID:23318641 xref: PMID:24063805 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0002086 ! primary gut branch relationship: develops_from PLANA:0000039 ! gamma neoblast relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/posteriorprimarygutbranch.png {comment="Depicted by field contains hematoxylin and eosin staining section of a asexual adult animal. The posterior primary gut branch is indicated by arrows. Scale bar = 250um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4812 [Term] id: PLANA:0000085 name: primitive gut cell namespace: Planarian_Anatomy def: "A phagocytic cell closely associated with the embryonic pharynx." [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0004518 ! extraembryonic cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_ends_during_or_before PLANA:0000005 ! Stage 5 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: part_of PLANA:0002087 ! primitive gut relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4826 [Term] id: PLANA:0000086 name: obsolete protosphere comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000087 name: proximal tubule namespace: Planarian_Anatomy def: "Ciliated epithelial cells form tubules, generating coiled, branching units terminating in flame bulbs. Tubules are formed via intercellular junctions between two epithelial cells. Proximal tubules are connected to non-ciliated distal tubules within the parenchyma." [] xref: PMID:21828097 xref: PMID:21937596 xref: PMID:26057828 xref: PMID:27068018 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000113 ! tissue relationship: adjacent_to PLANA:0000053 ! distal tubule relationship: adjacent_to PLANA:0000065 ! flame cell relationship: develops_from PLANA:0000011 ! protonephridial progenitor cell relationship: existence_starts_during_or_after PLANA:0000006 ! Stage 6 relationship: part_of PLANA:0000020 ! protonephridia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/proximaltubule.png {comment="Image is an electron micrograph depicting a proximal tubule (arrowheads) of the protonephridia structure. Note the cilia and the characteristic way the cell membrane connects with other proximal tubule epithelial cells. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4840 [Term] id: PLANA:0000088 name: renal system namespace: Planarian_Anatomy def: "The renal system is an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." [] synonym: "excretory system" EXACT [] synonym: "protonephridial system" EXACT [] xref: ISBN:9780070316607 xref: PMID:17670787 xref: PMID:19048075 xref: PMID:19247960 xref: PMID:19852954 xref: PMID:20707997 xref: PMID:21828097 xref: PMID:21937596 xref: PMID:22427692 xref: PMID:23079596 xref: PMID:23235145 xref: PMID:23903188 xref: PMID:24173799 xref: PMID:24523458 xref: PMID:24737865 xref: PMID:25254346 xref: PMID:26057828 xref: PMID:26711341 xref: PMID:27068018 xref: PMID:27542689 xref: PMID:28461239 xref: PMID:29674431 xref: PMID:30297872 xref: UBERON:0001008 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4848 [Term] id: PLANA:0000089 name: secondary gut branch namespace: Planarian_Anatomy def: "Gut branches, originating from and connected to the primary gut branches, that extend laterally towards the body edge." [] xref: PMID:21664348 xref: PMID:27122174 xref: PMID:28287248 xref: PMID:30471994 is_a: PLANA:0002119 ! gut branch property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/secondarygutbranch.png {comment="Depicted by field contains hematoxylin and eosin staining section of a asexual adult animal. The secondary gut branch is indicated by arrows. Scale bar = 250um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4867 [Term] id: PLANA:0000090 name: sperm namespace: Planarian_Anatomy def: "A mature male germ cell that develops from a spermatid." [] synonym: "mature sperm" EXACT [] synonym: "spermatozoa" EXACT [] xref: CL:0000019 xref: https://doi.org/10.1101/279364 xref: PMID:17390146 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:28072387 xref: PMID:29095551 is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000122 ! gamete is_a: PLANA:0000228 ! male germ cell relationship: develops_from PLANA:0000238 ! elongate spermatid relationship: part_of PLANA:0000208 ! testis relationship: produced_by PLANA:0000208 ! testis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4886 [Term] id: PLANA:0000091 name: obsolete sphere formation comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000092 name: yolk syncytium namespace: Planarian_Anatomy def: "Fused yolk cells surrounding blastomeres undergoing dispersed cleavage during Stages 1 and 2." [] synonym: "syncytial yolk cell" EXACT [] xref: PMID:15599763 is_a: BFO:0000040 ! material entity is_a: PLANA:0002136 ! syncytium relationship: existence_ends_during_or_before PLANA:0000002 ! Stage 2 relationship: existence_starts_during_or_after PLANA:0000001 ! Stage 1 relationship: produced_by PLANA:0000107 ! yolk cell relationship: RO:0002490 PLANA:0000001 ! existence overlaps Stage 1 relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4969 [Term] id: PLANA:0000093 name: tertiary gut branch namespace: Planarian_Anatomy def: "Gut branches originating from and connected to the secondary gut branches." [] synonym: "tertiary branch" EXACT [] synonym: "tertiary intestinal branch" EXACT [] xref: PMID:21664348 xref: PMID:23250205 xref: PMID:27122174 xref: PMID:28137894 xref: PMID:28287248 xref: PMID:30194301 xref: PMID:30471994 is_a: PLANA:0002119 ! gut branch property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/tertiarygutbranch.png {comment="Depicted by field contains hematoxylin and eosin staining section of a asexual adult animal. The tertiary gut branch indicated is by arrows. Scale bar = 250um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4927 [Term] id: PLANA:0000094 name: obsolete tissue morphogenesis comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000095 name: trail cell namespace: Planarian_Anatomy def: "Ovo+ neoblasts and post-mitotic eye progenitors that simultaneously migrate and differentiate into photoreceptor neurons and non-neuronal pigment cup cells comprising the optic cup." [] synonym: "eye progenitor" EXACT [] synonym: "eye progenitor cell" EXACT [] synonym: "ovo+ eye progenitor" EXACT [] xref: PMID:21852957 xref: PMID:22884275 xref: PMID:23250205 xref: PMID:24040508 xref: PMID:27606067 xref: PMID:28072387 xref: PMID:28245923 xref: PMID:29674431 xref: PMID:30485821 is_a: PLANA:0000429 ! neoblast relationship: existence_starts_during_or_after PLANA:0000006 ! Stage 6 relationship: part_of PLANA:0000124 ! visual system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4940 [Term] id: PLANA:0000096 name: ventral epidermis namespace: Planarian_Anatomy def: "Single cell layer of ventral, post-mitotic, heavily ciliated epithelial cells" [] synonym: "cilated ventral epidermis" EXACT [] synonym: "ciliated ventral epithelium" EXACT [] synonym: "ventral epidermin" EXACT [] synonym: "ventral epithelia" EXACT [] synonym: "ventral epithelium" EXACT [] synonym: "ventral region of epidermis" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000084 ! ventral region intersection_of: part_of PLANA:0000034 ! epidermis relationship: has_component BSPO:0000084 ! ventral region relationship: part_of PLANA:0000034 ! epidermis property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000097 name: ventral nerve cord namespace: Planarian_Anatomy def: "The pair of closely united ventral longitudinal nerves with their segmental ganglia that is characteristic of many elongate invertebrates (as earthworms)[BTO]. A large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring[WB]. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms[GO]." [] synonym: "nerve cord" EXACT [] synonym: "ventral cord" EXACT [] synonym: "VNC" EXACT [] xref: BTO:0002328 xref: EFO:0000896 xref: FBbt:00001102 xref: http://en.wikipedia.org/wiki/Ventral\:nerve\:cord xref: ISBN:9780070316607 xref: MAT:0000339 xref: MIAA:0000339 xref: nlx:146329 xref: PMID:16033796 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17390146 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:18063755 xref: PMID:18063757 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:19174194 xref: PMID:19211673 xref: PMID:19247960 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:20422023 xref: PMID:20599901 xref: PMID:20707997 xref: PMID:20967238 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21566185 xref: PMID:21806978 xref: PMID:21828097 xref: PMID:22074376 xref: PMID:22125640 xref: PMID:22339734 xref: PMID:22479207 xref: PMID:23250205 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23954785 xref: PMID:24063805 xref: PMID:24120894 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24950970 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25558068 xref: PMID:25772472 xref: PMID:25956527 xref: PMID:26017970 xref: PMID:26062938 xref: PMID:26457503 xref: PMID:26556349 xref: PMID:27013241 xref: PMID:27034770 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27612382 xref: PMID:28072387 xref: PMID:28126842 xref: PMID:28245923 xref: PMID:28807897 xref: PMID:29291974 xref: PMID:29674431 xref: PMID:30143032 xref: PMID:30471994 xref: UBERON:0000934 xref: WBbt:0005829 is_a: BFO:0000040 ! material entity is_a: PLANA:0000431 ! organ relationship: part_of PLANA:0000103 ! central nervous system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4954 [Term] id: PLANA:0000098 name: zygote namespace: Planarian_Anatomy def: "Diploid cell resulting from the fusion of male and female gametes at fertilization. [The_Dictionary_of_Cell_and_Molecular_Biology:Third_Edition ]." [] xref: BTO:0000854 xref: PMID:28812561 is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000068 ! embryo stage relationship: existence_ends_during_or_before PLANA:0000001 ! Stage 1 relationship: existence_starts_during_or_after PLANA:0000001 ! Stage 1 relationship: RO:0002490 PLANA:0000001 ! existence overlaps Stage 1 relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4971 [Term] id: PLANA:0000099 name: neuron namespace: Planarian_Anatomy def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [] synonym: "differentiated neuron" EXACT [] synonym: "nerve cell" EXACT [] synonym: "neural cell" EXACT [] synonym: "neuronal cell" EXACT [] xref: CL:0000540 xref: PMID:16033796 xref: PMID:16890156 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:19048075 xref: PMID:19174194 xref: PMID:19211673 xref: PMID:20215344 xref: PMID:21566185 xref: PMID:22411224 xref: PMID:22439894 xref: PMID:22479207 xref: PMID:22549959 xref: PMID:23297191 xref: PMID:23903188 xref: PMID:23954785 xref: PMID:24040508 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24737865 xref: PMID:24922054 xref: PMID:24950970 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25558068 xref: PMID:26457503 xref: PMID:26525673 xref: PMID:27013241 xref: PMID:27063937 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27542689 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:27864883 xref: PMID:28072387 xref: PMID:28126842 xref: PMID:28137894 xref: PMID:28245923 xref: PMID:28292427 xref: PMID:28461239 xref: PMID:28807897 xref: PMID:29100657 xref: PMID:29184198 xref: PMID:29291974 xref: PMID:29291981 xref: PMID:29357350 xref: PMID:29674432 xref: PMID:30143032 xref: PMID:30399335 is_a: PLANA:0000540 ! electrically signaling cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4713 [Term] id: PLANA:0000100 name: epithelial cell namespace: Planarian_Anatomy def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where the apical part is directed towards the lumen and the basal part to the basal lamina." [] synonym: "epidermis cell" EXACT [] xref: CL:0000066 xref: PMID:18202849 xref: PMID:19048075 xref: PMID:20865784 xref: PMID:22479207 xref: PMID:24737865 xref: PMID:26114597 xref: PMID:28072387 xref: PMID:28461239 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4570 [Term] id: PLANA:0000101 name: muscle cell namespace: Planarian_Anatomy def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [] synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: CL:0000187 xref: PMID:15972844 xref: PMID:18202849 xref: PMID:19174194 xref: PMID:20422023 xref: PMID:20511647 xref: PMID:21458439 xref: PMID:21828097 xref: PMID:22252539 xref: PMID:22479207 xref: PMID:23318641 xref: PMID:23405188 xref: PMID:23954785 xref: PMID:24415944 xref: PMID:24737865 xref: PMID:25254346 xref: PMID:25558068 xref: PMID:26062938 xref: PMID:27063937 xref: PMID:27523733 xref: PMID:28216315 xref: PMID:28287248 xref: PMID:28292427 xref: PMID:28461239 xref: PMID:28686611 xref: PMID:28807897 xref: PMID:28893948 xref: PMID:30471994 xref: PMID:30962434 is_a: PLANA:0000539 ! electrically responsive cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/musclecell.png {comment="Image is an electron micrograph depicting a muscle cell (arrowheads) cut in a transverse orientation with respect to the fiber length. Note the texture of the cytoplasm that comes from the organization of myofibrils. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4702 [Term] id: PLANA:0000102 name: anatomical region namespace: Planarian_Anatomy def: "A subdivision of an anatomical compartment." [] synonym: "body region" EXACT [] xref: PMID:28292427 xref: PMID:29547123 is_a: UBERON:0000475 ! organism subdivision property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4423 [Term] id: PLANA:0000103 name: central nervous system namespace: Planarian_Anatomy def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." [] synonym: "CNS" EXACT [] synonym: "head-restricted nervous system" EXACT [] xref: https://doi.org/10.1101/279364 xref: PMID:16033796 xref: PMID:16344473 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17553481 xref: PMID:17670787 xref: PMID:17905225 xref: PMID:17942485 xref: PMID:18063757 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:19174194 xref: PMID:19247960 xref: PMID:19933103 xref: PMID:20865784 xref: PMID:20967238 xref: PMID:21282632 xref: PMID:21295481 xref: PMID:21458439 xref: PMID:21664348 xref: PMID:21806978 xref: PMID:21828097 xref: PMID:22125640 xref: PMID:22252539 xref: PMID:22339734 xref: PMID:22385657 xref: PMID:22411224 xref: PMID:22427692 xref: PMID:22439894 xref: PMID:22445864 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23318641 xref: PMID:23903188 xref: PMID:24063805 xref: PMID:24173799 xref: PMID:24367277 xref: PMID:24704339 xref: PMID:24737865 xref: PMID:24922054 xref: PMID:24950970 xref: PMID:25356635 xref: PMID:25493551 xref: PMID:25772472 xref: PMID:25956527 xref: PMID:26017970 xref: PMID:26459857 xref: PMID:26711341 xref: PMID:26884331 xref: PMID:27013241 xref: PMID:27063937 xref: PMID:27068018 xref: PMID:27074666 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27240733 xref: PMID:27523733 xref: PMID:27542689 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:27800171 xref: PMID:27864883 xref: PMID:28126842 xref: PMID:28434803 xref: PMID:28461239 xref: PMID:28807897 xref: PMID:28976975 xref: PMID:29273738 xref: PMID:29291981 xref: PMID:30399335 xref: PMID:30471994 xref: PMID:30729158 xref: PMID:30962434 xref: UBERON:0001017 is_a: PLANA:0000025 ! nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4475 [Term] id: PLANA:0000104 name: rhabdite namespace: Planarian_Anatomy def: "Straight or curved rod-like structures within the epidermal cells, oriented with long axis at right angles to the epidermal surface, that are discharged into mucous secretions." [] xref: OCLC:16809160 is_a: PLANA:0000430 ! epithelial cell component property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/rhabdite.png {comment="Image is an electron micrograph depicting the epidermis. Inside of the epidermal cells, rhabdites (arrowheads) can be seen in various stages of expansion. Scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4853 [Term] id: PLANA:0000105 name: secretory cell namespace: Planarian_Anatomy def: "A cell that specializes in controlled release of one or more substances." [] xref: CL:0000151 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/secretorycell.png {comment="Image is an electron micrograph of a viscid gland cell (arrowheads) passing across the basal lamina (BL). This cell secretes a specialized type of mucus. The secretory duct transports mucus to the outside of the animal, through the secretory pore. Ventral is down and scale bar is 5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4868 [Term] id: PLANA:0000106 name: ciliated epithelial cell namespace: Planarian_Anatomy def: "An epithelial cell that has cilia." [] synonym: "ciliated epidermal cell" EXACT [] xref: CL:0000067 xref: PMID:24737865 xref: PMID:28461239 xref: PMID:28807897 is_a: PLANA:0000100 ! epithelial cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4493 [Term] id: PLANA:0000107 name: yolk cell namespace: Planarian_Anatomy def: "An extraembryonic cell, produced by somatic vitellogenic glands in adult hermaphrodites, that provides nutrition to the developing embryo." [] synonym: "vitellocyte" EXACT [] xref: CL:0000428 xref: ISBN:9780070316607 xref: PMID:22074376 xref: PMID:27149082 xref: PMID:28072387 xref: PMID:28434803 xref: PMID:29674431 is_a: PLANA:0000119 ! terminally differentiated cell is_a: PLANA:0000215 ! reproductive system product relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000060 ! embryonic wall relationship: produced_by PLANA:0000231 ! vitelline gland relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4968 [Term] id: PLANA:0000109 name: obsolete anatomical compartment subdivision feature comment: extra layer of complexity not needed upon further examination is_obsolete: true [Term] id: PLANA:0000110 name: pharynx progenitor cell namespace: Planarian_Anatomy def: "foxA1+ neoblasts and their post-mitotic, differentiating daughters required for maintenance and regeneration of the pharynx." [PMID:24737865, PMID:25254346] is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000111 name: proximal tubule epithelial cell namespace: Planarian_Anatomy def: "Ciliated epithelial cells that assemble into proximal tubules." [] synonym: "proximal tubule cell" EXACT [] xref: PMID:21828097 xref: PMID:29674431 is_a: BFO:0000040 ! material entity is_a: PLANA:0000106 ! ciliated epithelial cell relationship: part_of PLANA:0000087 ! proximal tubule relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/proximaltubuleepithelialcell.png {comment="Image is an electron micrograph of a proximal tubule epithelial cell (arrowheads). N = nucleus. Note the way the cell is wrapped around the cilia, creating the lumen in the middle. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4841 [Term] id: PLANA:0000112 name: obsolete Schmidtea mediterranea developmental term comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000113 name: tissue namespace: Planarian_Anatomy def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000000.md xref: UBERON:0000479 is_a: PLANA:0000427 ! multicellular anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4939 [Term] id: PLANA:0000114 name: anatomical system namespace: Planarian_Anatomy def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." [] xref: UBERON:0000467 is_a: PLANA:0000427 ! multicellular anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4425 [Term] id: PLANA:0000115 name: distal tubule epithelial cell namespace: Planarian_Anatomy def: "Nonciliated epithelial cells that assemble into protonephridial distal tubules." [] synonym: "distal tubule cell" EXACT [] xref: PMID:21828097 xref: PMID:29674431 is_a: BFO:0000040 ! material entity is_a: PLANA:0000015 ! non ciliated epithelial cell relationship: part_of PLANA:0000053 ! distal tubule relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/distaltubuleepithelialcell.png {comment="Image is an electron micrograph showing a cell (outlined) that is part of the collecting duct. Note how much more stained this cell is, compared to the surrounding ones. Also note the visible lumen of the collecting duct inside the cell where it is white and wrinkled. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4525 [Term] id: PLANA:0000116 name: embryo namespace: Planarian_Anatomy def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [] xref: UBERON:0000922 is_a: PLANA:0000215 ! reproductive system product property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4545 [Term] id: PLANA:0000117 name: embryonic structure namespace: Planarian_Anatomy def: "Anatomical structure that is part of an embryo." [] xref: UBERON:0002050 is_a: UBERON:0005423 ! developing anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4559 [Term] id: PLANA:0000118 name: collecting duct epithelial cell namespace: Planarian_Anatomy def: "Nonciliated epithelial cells that assemble into collecting ducts." [] xref: PMID:26057828 is_a: BFO:0000040 ! material entity is_a: PLANA:0000015 ! non ciliated epithelial cell relationship: part_of PLANA:0000047 ! collecting duct relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/collectingduct.png {comment="Image is an electron micrograph showing a cell (outlined) that is part of the collecting duct. Note how much more stained this cell is, compared to the surrounding ones. Also note the visible lumen of the collecting duct inside the cell where it is white and wrinkled. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4501 [Term] id: PLANA:0000119 name: terminally differentiated cell namespace: Planarian_Anatomy def: "A post-mitotic, terminally differentiated cell type found in planarian embryos, juveniles and/or adult animals." [] xref: PMID:29674432 is_a: PLANA:0002095 ! somatic cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4926 [Term] id: PLANA:0000120 name: progenitor cell namespace: Planarian_Anatomy def: "A cycling neoblast and/or post-mitotic cell that is primed or irreversibly committed to a tissue-specific differentation program" [] synonym: "precursor cell" EXACT [] xref: https://doi.org/10.1101/279364 xref: PMID:21852957 xref: PMID:29674432 is_a: PLANA:0000499 ! cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4829 [Term] id: PLANA:0000121 name: stem cell namespace: Planarian_Anatomy def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [] xref: CL:0000034 xref: https://doi.org/10.1101/279364 xref: PMID:17376870 xref: PMID:19805089 xref: PMID:20422023 xref: PMID:20707997 xref: PMID:21937596 xref: PMID:22385657 xref: PMID:23123964 xref: PMID:23318635 xref: PMID:24063805 xref: PMID:24173799 xref: PMID:26062938 xref: PMID:26651295 xref: PMID:26711341 xref: PMID:27013241 xref: PMID:27034770 xref: PMID:27501047 xref: PMID:29124009 is_a: PLANA:0000499 ! cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4906 [Term] id: PLANA:0000122 name: gamete namespace: Planarian_Anatomy def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [] xref: CL:0000300 xref: PMID:20844018 xref: PMID:23652002 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:28434803 is_a: PLANA:0000215 ! reproductive system product is_a: PLANA:0000227 ! germ cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: produced_by PLANA:0000217 ! gonad relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4611 [Term] id: PLANA:0000123 name: embryonic cell namespace: Planarian_Anatomy def: "A cell of the embryo." [] xref: CL:0002321 is_a: PLANA:0000499 ! cell relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4546 [Term] id: PLANA:0000124 name: visual system namespace: Planarian_Anatomy def: "The sensory system subserving the sense of vision." [] xref: UBERON:0002104 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4957 [Term] id: PLANA:0000125 name: sensory system namespace: Planarian_Anatomy def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." [] xref: UBERON:0001032 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4876 [Term] id: PLANA:0000126 name: reproductive system namespace: Planarian_Anatomy def: "Anatomical system that has as its parts the organs concerned with reproduction." [] xref: UBERON:0000990 is_a: PLANA:0000114 ! anatomical system relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4851 [Term] id: PLANA:0000127 name: oviduct epithelial cell namespace: Planarian_Anatomy def: "Ciliated epithelial cells that assemble into the oviduct." [] xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: PLANA:0000106 ! ciliated epithelial cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0004532 ! oviduct epithelium relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4749 [Term] id: PLANA:0000128 name: sperm duct epithelial cell namespace: Planarian_Anatomy def: "Ciliated epithelial cells comprising the sperm ducts." [] xref: PMID:19022767 xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: PLANA:0000106 ! ciliated epithelial cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0004533 ! sperm duct epithelium relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4888 [Term] id: PLANA:0000129 name: obsolete anatomical structure comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0000061 [Term] id: PLANA:0000130 name: circular muscle progenitor cell namespace: Planarian_Anatomy def: "piwi-1+, nkx1-1+ progenitor neoblasts required for specification of circular muscle fibers." [] xref: PMID:29168507 is_a: PLANA:0000019 ! muscle progenitor cell is_a: PLANA:0000429 ! neoblast is_a: PLANA:0002095 ! somatic cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4498 [Term] id: PLANA:0000131 name: primordium namespace: Planarian_Anatomy def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue." [] xref: UBERON:0001048 is_a: UBERON:0007567 ! regenerating anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4827 [Term] id: PLANA:0000132 name: obsolete gametogenesis comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000133 name: mechanoreceptor cell namespace: Planarian_Anatomy def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [] synonym: "mechanoreceptor" EXACT [] xref: PMID:18202849 xref: PMID:7466176 is_a: PLANA:0000552 ! sensory neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4668 [Term] id: PLANA:0000134 name: longitudinal muscle progenitor cell namespace: Planarian_Anatomy def: "piwi-1+, myoD+, snail-1+ progenitor neoblasts required for specification and creation of longitudinal muscle fibers." [] xref: PMID:29168507 is_a: PLANA:0000019 ! muscle progenitor cell is_a: PLANA:0000429 ! neoblast property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4661 [Term] id: PLANA:0000135 name: female primordial germ cell namespace: Planarian_Anatomy def: "Cells expressing nanos that are located ventrally in the location that the ovaries form. Primordial germ cells are present in both asexual adults and sexual hermaphrodites. This term may be redundant with oogonial stem cell." [] xref: PMID:17390146 is_a: BFO:0000040 ! material entity is_a: PLANA:0000121 ! stem cell is_a: PLANA:0000229 ! female germ cell relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4589 [Term] id: PLANA:0000136 name: whole organism namespace: Planarian_Anatomy def: "Anatomical structure that is an individual member of of Schmidtea mediterranea or any other flatworm of the class Turbellaria." [] synonym: "intact animal" EXACT [] synonym: "intact planarian" EXACT [] synonym: "whole animal" EXACT [] synonym: "whole body" EXACT [] synonym: "whole worm" EXACT [] synonym: "WW" EXACT [] xref: PMID:17251262 xref: PMID:26711341 xref: PMID:27502555 xref: PMID:28976975 xref: PMID:29906446 xref: UBERON:0000468 is_a: UBERON:0000061 ! anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4962 [Term] id: PLANA:0000137 name: regeneration namespace: Planarian_Anatomy def: "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [] synonym: "regernative development" EXACT [] xref: GO:0031099 xref: GOC:mah xref: GOC:pr xref: Wikipedia:Regeneration\:(biology) is_a: GO:0048856 ! anatomical structure development property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4846 [Term] id: PLANA:0000138 name: Hyman vesicle namespace: Planarian_Anatomy def: "PROG-2-5 positive granules that range in size from 0.5um to 1um present in epithelia and epithelia progenitor cells. These are distinct from rhabdites." [] xref: PMID:29100657 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0002137 ! intracellular granule relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/hymanvesicle.png {comment="Image is an immunoelectron micrograph depicting hyman vesicles in the apical side of an epidermal cell. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4636 [Term] id: PLANA:0000140 name: anterior region of the whole animal namespace: Planarian_Anatomy def: "Compartment along the anteroposterior axis closer to the head rather than the tail, from the head margin to the esophagus." [OCLC:16809160] synonym: "anterior region of whole organism" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000071 ! anterior region relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000141 name: dorsal region of the whole animal namespace: Planarian_Anatomy def: "Three dimensional compartment along the dorsoventral axis that is above the anteroposterior axis, containing the eyes." [] synonym: "dorsal region of whole organism" EXACT [] is_a: PLANA:0000143 ! ventral region of the whole animal intersection_of: has_component BSPO:0000079 ! dorsal region intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000079 ! dorsal region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000142 name: posterior compartment of the whole animal namespace: Planarian_Anatomy def: "Three dimensional compartment along the anteroposterior axis that is closer to the tail rather than the head, from the anterior boundary of the pharyngeal pouch to the tip of the tail." [] synonym: "posterior compartment of whole organism" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000090 ! posterior compartment intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000090 ! posterior compartment relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000143 name: ventral region of the whole animal namespace: Planarian_Anatomy def: "Compartment along the dorsoventral axis that is below the anteroposterior axis." [] synonym: "ventral region of whole organism" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000084 ! ventral region intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000084 ! ventral region relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0000201 name: bursal canal namespace: Planarian_Anatomy def: "The passageway connecting the genital atrium to the copulatory bursa. Part of the copulatory apparatus. During mating, sperm from a partner is deposited into the bursal canal, where it collects in the copulatory bursa before travelling up the oviducts to the tuba." [] xref: ISBN:9780070316607 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:25278423 xref: PMID:27149082 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000232 ! copulatory apparatus relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4460 [Term] id: PLANA:0000203 name: gonopore namespace: Planarian_Anatomy def: "The gonopore, a component of the copulatory apparatus, is an opening located on the ventral side of the animal posterior to the pharynx. The gonopore is the sole point of exit and entry for the reproductive system, allowing from reciprocal exchange of sperm during copulation and egg capsule laying." [] synonym: "common gonopore" EXACT [] synonym: "genital pore" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:19247960 xref: PMID:20967238 xref: PMID:21566185 xref: PMID:22074376 xref: PMID:22899852 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:28072387 xref: PMID:28434803 is_a: BFO:0000040 ! material entity is_a: PLANA:0002079 ! pore relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000232 ! copulatory apparatus relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4631 [Term] id: PLANA:0000204 name: ovary namespace: Planarian_Anatomy def: "A gonad containing female germline stem cells which fuel oocyte production. Two ovaries are located ventally, underneath the body wall musculature, immediately posterior to the cephalic ganglia (brain) and adjacent to the ventral nerve cords. The neoblast compartment, including piwi-1+, nanos+ primordial germ cells, fuel formation of the ovaries during juvenile development." [] synonym: "female gonad" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:17390146 xref: PMID:18456843 xref: PMID:19247960 xref: PMID:20844018 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:22318224 xref: PMID:22371573 xref: PMID:23652002 xref: PMID:25278423 xref: PMID:25404302 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:27330085 xref: PMID:28072387 xref: PMID:28434803 xref: PMID:28812561 is_a: BFO:0000040 ! material entity is_a: PLANA:0000217 ! gonad relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4745 [Term] id: PLANA:0000205 name: oviduct namespace: Planarian_Anatomy def: "Ciliated tubes adjacent to the ventral nerve cords, adjoining the tuba and the bursal canal, that transport fertilized oocytes to the genital atrium." [] synonym: "ovovitilline duct" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:19247960 xref: PMID:20844018 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:23652002 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: PLANA:0002089 ! reproductive organ relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4748 [Term] id: PLANA:0000206 name: penis papilla namespace: Planarian_Anatomy def: "A rounded protuberance, connected to the seminal vesicles, responsible for transferring semen into a mating partner's bursal canal." [] synonym: "penis" EXACT [] synonym: "penis bulb" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:23652002 xref: PMID:25278423 xref: PMID:27074666 xref: PMID:28072387 xref: PMID:28434803 is_a: BFO:0000040 ! material entity is_a: PLANA:0002089 ! reproductive organ relationship: part_of PLANA:0000232 ! copulatory apparatus relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4761 [Term] id: PLANA:0000207 name: sperm duct namespace: Planarian_Anatomy def: "A network of tubes that transport sperm from the testes to the seminal vesicles. Tubes connect each testis to ducts that run along the ventral nerve cords. The ducts bifurcate immediately posterior to the pharynx, where they connect to the seminal vesicles." [] synonym: "seminal duct" EXACT [] synonym: "sperm ductule" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:17390146 xref: PMID:19022767 xref: PMID:19247960 xref: PMID:20844018 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:23652002 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:27304889 xref: PMID:28072387 xref: PMID:28434803 is_a: BFO:0000040 ! material entity is_a: PLANA:0002089 ! reproductive organ relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4887 [Term] id: PLANA:0000208 name: testis namespace: Planarian_Anatomy def: "A gonad containing male germline stem cells which fuel sperm production. Testes are located dorsolaterally, and are excluded from the head. The neoblast compartment, including piwi-1+, nanos+ primordial germ cells, fuels formation of testes during juvenile development and regeneration." [] synonym: "male gonad" EXACT [] synonym: "testis lobe" EXACT [] synonym: "testis lobule" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:18456843 xref: PMID:19022767 xref: PMID:19247960 xref: PMID:20844018 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:22318224 xref: PMID:22371573 xref: PMID:23629965 xref: PMID:23652002 xref: PMID:25278423 xref: PMID:25404302 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:27330085 xref: PMID:28072387 xref: PMID:28434803 xref: PMID:28812561 xref: PMID:29095551 is_a: BFO:0000040 ! material entity is_a: PLANA:0000217 ! gonad relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4928 [Term] id: PLANA:0000209 name: obsolete developing anatomical structure comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0005423 [Term] id: PLANA:0000211 name: primitive ectoderm cell namespace: Planarian_Anatomy def: "Primitive ectoderm cells differentiate from the blastomere population, exit the cell cycle and interact to boud the embryo during Stage 2." [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000001.md xref: OCLC:20423827 xref: OCLC:464776945 xref: OCLC:82522822 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000106 ! ciliated epithelial cell is_a: PLANA:0004518 ! extraembryonic cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000029 ! primitive ectoderm relationship: RO:0001018 PLANA:0000041 ! contained in aboral hemisphere relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4823 [Term] id: PLANA:0000212 name: obsolete blastomere compartment comment: replace with blastomere only is_obsolete: true replaced_by: PLANA:0004517 [Term] id: PLANA:0000214 name: juvenile namespace: Planarian_Anatomy def: "A sexually immature member of the Schmidtea mediterranea sexuallly reproducing biotype." [] is_a: UBERON:0000105 ! life cycle stage relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4649 [Term] id: PLANA:0000215 name: reproductive system product namespace: Planarian_Anatomy def: "Products of the reproductive system include gametes, zygotes, yolk cells and egg capsules." [] is_a: BFO:0000040 ! material entity is_a: UBERON:0000061 ! anatomical structure relationship: produced_by PLANA:0000126 ! reproductive system relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4852 [Term] id: PLANA:0000216 name: egg capsule namespace: Planarian_Anatomy def: "A proteinaceous, semi-permeable shell housing yolk cells and one or more embryos.Egg capsules are anchored to a substrate via a stalk." [] synonym: "capsule" EXACT [] synonym: "cocoon" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:18942102 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:22371573 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:28072387 xref: PMID:28434803 xref: PMID:28812561 is_a: PLANA:0000215 ! reproductive system product relationship: produced_by PLANA:0004503 ! adult hermaphrodite property_value: foaf:depiction urn:dosdp:depicted:by {comment="Depicted by field shows a light microscopy image of egg capsules with a scale bar of 3mm"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4541 [Term] id: PLANA:0000217 name: gonad namespace: Planarian_Anatomy def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:17390146 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:22252538 xref: PMID:22371573 xref: PMID:23652002 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:28434803 xref: PMID:28976975 xref: UBERON:0000991 is_a: PLANA:0002089 ! reproductive organ property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4629 [Term] id: PLANA:0000218 name: male primordial germ cell namespace: Planarian_Anatomy def: "Cells coexpressing piwi-1 and nanos that are required for male gonad formation. Primordial germ cells are present in both asexual adults and sexual hermaphrodites. This term may be redundant with spermatogonial stem cell." [] xref: PMID:17376870 xref: PMID:17390146 is_a: BFO:0000040 ! material entity is_a: PLANA:0000121 ! stem cell is_a: PLANA:0000228 ! male germ cell relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4666 [Term] id: PLANA:0000219 name: spermatogonial stem cell namespace: Planarian_Anatomy def: "gh4+, nanos+ cells residing at the testis periphery that self-renew and give rise to differentiating daughters that will ultimately produce haploid sperm." [] synonym: "male germline stem cell" EXACT [] synonym: "SSC" EXACT [] xref: PMID:19022767 xref: PMID:20844018 xref: PMID:27163480 xref: PMID:27330085 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000121 ! stem cell is_a: PLANA:0000228 ! male germ cell relationship: develops_from PLANA:0000429 ! neoblast relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000208 ! testis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4894 [Term] id: PLANA:0000220 name: spermatogonium namespace: Planarian_Anatomy def: "An euploid male germ cell of an early stage of spermatogenesis. In planaria, the gh4+ stem cell daughter exiting the niche undergoes three rounds of transit amplifying division with incomplete cytokinesis prior to transitioning to terminal differentiation." [] synonym: "spermatogonial cell" EXACT [] xref: CL:0000020 xref: https://doi.org/10.1101/279364 xref: PMID:23629965 xref: PMID:27163480 xref: PMID:27330085 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000120 ! progenitor cell is_a: PLANA:0000228 ! male germ cell relationship: develops_from PLANA:0000219 ! spermatogonial stem cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000208 ! testis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4895 [Term] id: PLANA:0000221 name: spermatocyte namespace: Planarian_Anatomy def: "A tektin-1+ male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [] synonym: "primary spermatocyte" EXACT [] xref: CL:0000017 xref: PMID:17376870 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:25278423 xref: PMID:25404302 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:27330085 xref: PMID:29095551 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000228 ! male germ cell relationship: develops_from PLANA:0000220 ! spermatogonium relationship: part_of PLANA:0000208 ! testis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4893 [Term] id: PLANA:0000222 name: spermatid namespace: Planarian_Anatomy def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [] xref: CL:0000018 xref: PMID:17376870 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:25278423 xref: PMID:25404302 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:27330085 is_a: BFO:0000040 ! material entity is_a: PLANA:0000228 ! male germ cell relationship: part_of PLANA:0000208 ! testis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4892 [Term] id: PLANA:0000223 name: oogonial stem cell namespace: Planarian_Anatomy def: "A piwi-1+, nanos+ cell residing in the ovary that self-renews and give rise to oogonial cells that differentiate into oocytes." [] synonym: "female germ cell" EXACT [] synonym: "female germline cell" EXACT [] synonym: "female germline stem cell" EXACT [] synonym: "oogonial stem cell" EXACT [] synonym: "ovarian germline stem cell" EXACT [] xref: PMID:19022767 xref: PMID:20844018 xref: PMID:23652002 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:27330085 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000121 ! stem cell is_a: PLANA:0000229 ! female germ cell relationship: develops_from PLANA:0000429 ! neoblast relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000204 ! ovary relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4734 [Term] id: PLANA:0000224 name: cement gland namespace: Planarian_Anatomy def: "Glands surrounding the genital atrium that are required for production of the proteinaceous egg capsule shell and stalk." [] synonym: "shell gland" EXACT [] xref: ASIN:B000M4NK9M xref: ISBN:9780070316607 xref: PMID:18942102 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:23652002 xref: PMID:25278423 xref: PMID:27149082 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000232 ! copulatory apparatus relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4474 [Term] id: PLANA:0000225 name: obsolete oviparity comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000226 name: obsolete cross-fertilization comment: removing all processes. may bring back if PLANA expanded to cover processes. is_obsolete: true [Term] id: PLANA:0000227 name: germ cell namespace: Planarian_Anatomy def: "1. A gamete (as an egg or sperm cell) or one of its antecedent cells. 2. A mature male or female germ cell usually possessing a haploid chromosome set and capable of initiating formation of a new diploid individual by fusion with a gamete of the opposite sex." [] xref: BTO:0000535 is_a: PLANA:0000499 ! cell relationship: part_of PLANA:0000126 ! reproductive system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4622 [Term] id: PLANA:0000228 name: male germ cell namespace: Planarian_Anatomy def: "A male germ cell is a germ cell that supports male gamete production." [] xref: CL:0000015 xref: PMID:23652002 xref: PMID:27304889 xref: PMID:27330085 is_a: PLANA:0000227 ! germ cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4665 [Term] id: PLANA:0000229 name: female germ cell namespace: Planarian_Anatomy def: "Female germ cell is a germ cell that supports female gamete production." [] xref: CL:0000021 is_a: PLANA:0000227 ! germ cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4588 [Term] id: PLANA:0000230 name: tuba namespace: Planarian_Anatomy def: "A sperm storage organ located immediately posterior to the ovary, at the anterior end of the oviduct. Oocytes exiting the ovary are fertilized in the tuba as they enter the oviduct." [] xref: PMID:19022767 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:25278423 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:28434803 is_a: BFO:0000040 ! material entity is_a: PLANA:0002089 ! reproductive organ relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4945 [Term] id: PLANA:0000231 name: vitelline gland namespace: Planarian_Anatomy def: "Glands surrounding the oviducts which produce yolk cells. Yolk cells deposited into the oviducts travel to the genital atrium where they are packaged, along with one or more zygotes, into developing egg capsules." [] synonym: "vitellaria" EXACT [] synonym: "vitellarium" EXACT [] synonym: "yolk gland" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:16932928 xref: PMID:17390146 xref: PMID:18942102 xref: PMID:19247960 xref: PMID:22074376 xref: PMID:23652002 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:27501047 xref: PMID:28072387 xref: PMID:28434803 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000126 ! reproductive system relationship: produces PLANA:0000107 ! yolk cell relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4959 [Term] id: PLANA:0000232 name: copulatory apparatus namespace: Planarian_Anatomy def: "Accessory reproductive structures involved in copulation, egg capsule development and laying." [] synonym: "copulatory complex" EXACT [] xref: ISBN:9780070316607 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:17390146 xref: PMID:19247960 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:23652002 xref: PMID:27149082 xref: PMID:27163480 xref: PMID:28434803 is_a: BFO:0000040 ! material entity is_a: PLANA:0002090 ! reproductive structure relationship: part_of PLANA:0000126 ! reproductive system relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4503 [Term] id: PLANA:0000233 name: copulatory bursa namespace: Planarian_Anatomy def: "An organ that receives and stores sperm from mating partners." [] synonym: "bursa" EXACT [] synonym: "male antrum" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 xref: PMID:20967238 xref: PMID:22074376 xref: PMID:25278423 is_a: BFO:0000040 ! material entity is_a: PLANA:0002089 ! reproductive organ relationship: part_of PLANA:0000232 ! copulatory apparatus relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4504 [Term] id: PLANA:0000234 name: seminal vesicle namespace: Planarian_Anatomy def: "Glandular pouches adjoining the sperm ducts which produce seminal fluid." [] xref: PMID:19022767 xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: PLANA:0002089 ! reproductive organ relationship: part_of PLANA:0000232 ! copulatory apparatus relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4873 [Term] id: PLANA:0000237 name: round spermatid namespace: Planarian_Anatomy def: "A cyst of 8 interconnected spermatocytes undergoes meiosis, producing 32 haploid round spermatids. Round spermatids express protein kinase A, andundergo morphogenesis to produce mature sperm." [] xref: https://doi.org/10.1101/279364 xref: PMID:20844018 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:27330085 xref: PMID:29095551 is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000222 ! spermatid relationship: develops_from PLANA:0000221 ! spermatocyte property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4856 [Term] id: PLANA:0000238 name: elongate spermatid namespace: Planarian_Anatomy def: "Spermatids expressing protein kinase A undergoing morphogenic changes to make mature sperm." [] synonym: "elongating spermatid" EXACT [] xref: PMID:20844018 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:27330085 xref: PMID:29095551 is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000222 ! spermatid relationship: develops_from PLANA:0000237 ! round spermatid property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4544 [Term] id: PLANA:0000239 name: oogonial cell namespace: Planarian_Anatomy def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [] xref: FMA:83673 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000120 ! progenitor cell is_a: PLANA:0000229 ! female germ cell relationship: develops_from PLANA:0000223 ! oogonial stem cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000204 ! ovary relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4733 [Term] id: PLANA:0000240 name: body wall musculature namespace: Planarian_Anatomy def: "Any collection of muscles that is part of a body wall [Automatically generated definition]." [] synonym: "body muscle" EXACT [] synonym: "body wall muscle" EXACT [] synonym: "body wall muscles" EXACT [] synonym: "body-wall muscle" EXACT [] synonym: "body-wall musculature" EXACT [] synonym: "BWM" EXACT [] synonym: "muscle layer surrounding the body wall" EXACT [] xref: BSA:0000058 xref: BTO:0001863 xref: FMA:86931 xref: PMID:19048075 xref: PMID:19174194 xref: PMID:21828097 xref: PMID:22385657 xref: PMID:24992682 xref: PMID:27063937 xref: PMID:27074666 xref: PMID:28171748 xref: PMID:29100657 xref: PMID:29547123 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:30471994 xref: PMID:30962434 xref: UBERON:0004462 xref: WBbt:0005813 is_a: BFO:0000040 ! material entity is_a: PLANA:0000431 ! organ relationship: part_of PLANA:0000428 ! musculature system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/bodywallmusculature.png {comment="http://purl.obolibrary.org/obo/Image is an electron micrograph of the dorsal epidermis, basal lamina (BL), and underlying body wall musculature. Three types of muscle cells have been color coded form superficial to deep_ Circular muscle = magenta; longitudinal muscle = green; diagonal muscle = red. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4454 [Term] id: PLANA:0000241 name: pharynx longitudinal muscle cell namespace: Planarian_Anatomy def: "Pharynx muscle fibers running anteroposterior (proximal to distal)." [] synonym: "pharyngeal longitudinal muscle cell" EXACT [] synonym: "pharyngeal longitudinal muscle fiber" EXACT [] synonym: "pharynx longitudinal muscle fiber" EXACT [] xref: ASIN:B000M4NK9M is_a: PLANA:0000101 ! muscle cell relationship: part_of PLANA:0000478 ! pharynx musculature relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxlongitudinalmusclecell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The inner longitudinal muscle (arrowheads) is immediately deep to the inner circular muscle of the pharynx. Magenta = circular; green = longitudinal; red = radial. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4776 [Term] id: PLANA:0000242 name: obsolete anatomical cavity comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0002553 [Term] id: PLANA:0000400 name: obsolete anatomical entity comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0001062 [Term] id: PLANA:0000401 name: obsolete immaterial anatomical entity comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0000466 [Term] id: PLANA:0000402 name: obsolete anatomical point comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0006983 [Term] id: PLANA:0000403 name: obsolete anatomical space comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0000464 [Term] id: PLANA:0000404 name: pharynx lumen namespace: Planarian_Anatomy def: "Anatomical space enclosed by the pharynx inner epithelium." [] synonym: "cavity of pharynx" EXACT [] synonym: "pharyngeal lumen" EXACT [] synonym: "pharynx cavity" EXACT [] xref: PMID:17251262 xref: PMID:26711341 xref: PMID:27502555 xref: PMID:28976975 xref: PMID:29906446 xref: UBERON:0000468 is_a: BFO:0000040 ! material entity is_a: PLANA:0002053 ! lumen relationship: immediately_deep_to PLANA:0000412 ! pharynx inner epithelium surface relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/cavityofpharynx.png {comment="Depicted by field contains hematoxylin and eosin staining section of a asexual adult animal. Cavity of pharynx is indicated by arrows. Scale bar = 250um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4777 [Term] id: PLANA:0000405 name: digestive tract lumen namespace: Planarian_Anatomy def: "An anatomical space that is surrounded by a digestive tract." [] synonym: "digestive system lumen" EXACT [] synonym: "gut cavity" EXACT [] synonym: "lumen of digestive tract" EXACT [] xref: PMID:17553481 xref: PMID:21664348 xref: PMID:21828097 xref: PMID:28072387 xref: UBERON:0006909 is_a: BFO:0000040 ! material entity is_a: PLANA:0002053 ! lumen relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0000026 ! gut relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/lumenofdigestivetract.png {comment="Depicted by field contains hematoxylin and eosin staining on a coronal section of a asexual adult animal. The lumen of the digestive tract is indicated by arrows. Scale bar = 250um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4520 [Term] id: PLANA:0000406 name: oral opening namespace: Planarian_Anatomy def: "The orifice that connects the mouth to the exterior of the body." [] synonym: "pharyngeal mouth opening" EXACT [] synonym: "pharynx opening" EXACT [] xref: PMID:17670787 xref: PMID:29674431 xref: PMID:30399335 is_a: BFO:0000040 ! material entity is_a: UBERON:0002553 ! anatomical cavity relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: part_of PLANA:0000023 ! embryonic pharynx relationship: part_of PLANA:0000072 ! mouth relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4974 [Term] id: PLANA:0000407 name: pharynx pouch cavity namespace: Planarian_Anatomy def: "Anatomical space between the pharynx and the epithelial cells comprising parapharyngeal pouch." [] synonym: "pharnygeal cavity" EXACT [] synonym: "pharyngeal pouch cavity" EXACT [] xref: OCLC:16809160 is_a: BFO:0000040 ! material entity is_a: UBERON:0002553 ! anatomical cavity relationship: part_of PLANA:0000081 ! pharynx pouch relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/parapharyngealpouchcavity.png {comment="Depicted by field contains hematoxylin and eosin stainingcoronal section section of a asexual adult animal. Parapharyngeal pouch cavity is indicated by arrows. Scale bar = 250um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4789 [Term] id: PLANA:0000409 name: apical surface of the epidermis namespace: Planarian_Anatomy def: "The apical surface of the single layered epidermis that is in contact with the environment." [] synonym: "apical surface of epidermis" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000373 ! apical surface intersection_of: part_of PLANA:0000034 ! epidermis relationship: has_component BSPO:0000373 ! apical surface relationship: part_of PLANA:0000034 ! epidermis property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/apicalepidermissurface.png {comment="Electron micrograph of the dorsal epidermis in a transverse plane from an asexual adult animal. The apical epidermis surface is noted with magenta arrows. Scale bar is 5um."} [Term] id: PLANA:0000410 name: basal surface of the epidermis namespace: Planarian_Anatomy def: "The basal surface of the epidermis in direct contact with the basal lamina." [] synonym: "basal surface of epidermis" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000374 ! basal surface intersection_of: part_of PLANA:0000034 ! epidermis relationship: has_component BSPO:0000374 ! basal surface relationship: part_of PLANA:0000034 ! epidermis property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/basalepidermissurface.png {comment="Electron micrograph of the dorsal epidermis in a transverse plane. The basal epidermis surface is noted with magenta arrows. Scale bar is 5um."} [Term] id: PLANA:0000411 name: gastrodermis surface namespace: Planarian_Anatomy def: "The surface of the gastrodermis in contact with the gut lumen." [] synonym: "lumen gut surface" EXACT [] xref: PMID:21664348 is_a: BSPO:0000005 ! anatomical surface relationship: part_of PLANA:0000026 ! gut relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/lumengutsurface.png {comment="The depicted by field is a hemotoxylin and eosin stained coronal section encompassing the anterior primary gut branch. The lumen gut surface is marked by black arrows. Scale bar is 200um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4618 [Term] id: PLANA:0000412 name: pharynx inner epithelium surface namespace: Planarian_Anatomy def: "The epithelial surface lining the interior of the pharynx, facing the lumen." [] synonym: "pharyngeal inner epidermis surface" EXACT [] synonym: "pharyngeal inner epithelial surface" EXACT [] synonym: "pharyngeal lumen epithelial surface" EXACT [] synonym: "pharynx inner epidermis surface" EXACT [] synonym: "pharynx lumen epithelial surface" EXACT [] xref: UBERON:0001731 is_a: BSPO:0000005 ! anatomical surface relationship: part_of PLANA:0007534 ! pharynx inner epithelium relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxinnerepitheliumsurface.png {comment="Image is an electron micrograph of a transverse section through the pharynx. An epidermal cell, a part of the inner epithelial layer, has been marked with arrowheads. Immediately deep to the inner epithelial layer of the pharynx is musculature that has been colored. Magenta = circular; blue = longitudinal; yellow = radial. Scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4773 [Term] id: PLANA:0000413 name: pharynx outer epithelium surface namespace: Planarian_Anatomy def: "Epithelial surface covering the outside of the pharynx." [] synonym: "pharyngeal outer epidermis surface" EXACT [] synonym: "pharyngeal outer epithelial surface" EXACT [] synonym: "pharynx outer epidermis surface" EXACT [] synonym: "pharynx outer side" EXACT [] xref: doi:10.1002/jmor.1052060308 xref: PMID:24120894 xref: PMID:29865769 is_a: BSPO:0000005 ! anatomical surface relationship: part_of PLANA:0000472 ! pharynx outer epithelium relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxouterepithelium.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The pharynx pouch cavity is at the top. The outer epithelium has been labeled with arrowheads. Immediately deep to the outer epithelial layer of the pharynx is musculature that has been colored. Red = circular; blue = longitudinal. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4785 [Term] id: PLANA:0000414 name: pharynx pouch epithelial surface namespace: Planarian_Anatomy def: "The surface of the parapharyngeal pouch facing the pharynx." [] synonym: "pharyngeal pouch surface" EXACT [] synonym: "pharynx pouch surface" EXACT [] xref: OCLC:16809160 is_a: BSPO:0000005 ! anatomical surface relationship: part_of PLANA:0002140 ! pharynx pouch epithelium relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/parapharyngealpouchsurface.png {comment="The depicted by field is a hemotoxylin and eosin stained coronal section encompassing the pharynx and surrounding tissues. Anterior is up. The parapharyngeal pouch surface is marked by black arrows. Scale bar is 200um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4791 [Term] id: PLANA:0000416 name: obsolete organism subdivision comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0000475 [Term] id: PLANA:0000417 name: definitive organism subdivision namespace: Planarian_Anatomy def: "Anatomical structure which is a subdivision of a whole adult or juvenile organism, consisting of components of multiple anatomical systems." [] is_a: UBERON:0000475 ! organism subdivision property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4511 [Term] id: PLANA:0000418 name: head namespace: Planarian_Anatomy def: "The head is the anterior-most division of the body [GO]. A three dimensional compartment bounded by the anterior margin or the head and the posterior boundary of the cephalic ganglia (brain)." [] xref: UBERON:0000033 is_a: PLANA:0000102 ! anatomical region relationship: anterior_to PLANA:0000419 ! prepharyngeal region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/head.png {comment="Depicted by field contains diagram representation of body region."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4634 [Term] id: PLANA:0000419 name: prepharyngeal region namespace: Planarian_Anatomy def: "Region of the juvenile or adult animal between the posterior end of the cephalic ganglia and the anterior end of the pharynx." [] synonym: "neck" EXACT [] synonym: "pre-pharyngeal region" EXACT [] synonym: "pre-pharynx region" EXACT [] xref: OCLC:16809160 is_a: PLANA:0000102 ! anatomical region relationship: anterior_to PLANA:0000420 ! parapharyngeal region relationship: posterior_to PLANA:0000418 ! head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/neck.png {comment="Depicted by field contains diagram representation of body region."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4817 [Term] id: PLANA:0000420 name: parapharyngeal region namespace: Planarian_Anatomy def: "Region of the animal lateral to and surrounding the pharynx." [] comment: Trunk is a synonym here because the parapharyngeal region is always contained in a trunk fragment. However, a trunk fragment may also contain some neck and some tail. synonym: "para-pharyngeal" EXACT [] synonym: "parapharyngeal" EXACT [] synonym: "peri-pharyngeal" EXACT [] synonym: "peripharyngeal region" EXACT [] synonym: "trunk" EXACT [] xref: PMID:22125640 xref: PMID:25956527 xref: PMID:26651295 xref: PMID:28807897 xref: PMID:29674431 xref: PMID:30143032 is_a: PLANA:0000102 ! anatomical region relationship: anterior_to PLANA:0000421 ! tail relationship: anterior_to PLANA:0004527 ! copulatory region relationship: posterior_to PLANA:0000419 ! prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/parapharyngealregion.png {comment="Depicted by field contains diagram representation of body region."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4754 [Term] id: PLANA:0000421 name: tail namespace: Planarian_Anatomy def: "Caudal region, beginning at the mouth and ending at posterior pole." [] is_a: PLANA:0000102 ! anatomical region relationship: posterior_to PLANA:0004527 ! copulatory region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/tail.png {comment="Depicted by field contains diagram representation of body region."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4915 [Term] id: PLANA:0000422 name: tail stripe namespace: Planarian_Anatomy def: "Medial region of the tail; the parenchymal space between the posterior primary gut branches." [] is_a: PLANA:0000102 ! anatomical region relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4917 [Term] id: PLANA:0000423 name: embryonic subdivision namespace: Planarian_Anatomy def: "Anatomical structure which is a subdivision of a whole developing/ embryonic organism, consisting of components of multiple anatomical systems." [] is_a: UBERON:0000475 ! organism subdivision relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4560 [Term] id: PLANA:0000424 name: obsolete material anatomical entity comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0000465 [Term] id: PLANA:0000425 name: obsolete definitive anatomical structure comment: extra layer of complexity not needed upon further examination is_obsolete: true [Term] id: PLANA:0000426 name: obsolete acellular anatomical structure comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0000476 [Term] id: PLANA:0000427 name: multicellular anatomical structure namespace: Planarian_Anatomy def: "An anatomical structure that has more than one cell as a part." [] xref: UBERON:0010000 is_a: UBERON:0000061 ! anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4700 [Term] id: PLANA:0000428 name: musculature system namespace: Planarian_Anatomy def: "Total musculature of the planarian body." [] synonym: "muscular system" EXACT [] synonym: "musculature" EXACT [] xref: http://purl.obolibrary.org/obo/UBERON\:0001015 xref: ISBN:9780070316607 xref: PMID:15866156 xref: PMID:17942485 xref: PMID:20707997 xref: PMID:24950970 xref: PMID:27068018 xref: PMID:28137894 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4704 [Term] id: PLANA:0000429 name: neoblast namespace: Planarian_Anatomy def: "A heterogeneous population of pluripotent, somatic adult stem cells and lineage primed progenitors that are required for maintenance and regeneration of all cell types in planaria, including the germline." [] synonym: "adult somatic stem cell" EXACT [] synonym: "adult stem cell" EXACT [] synonym: "ASC" EXACT [] synonym: "cycling cell" EXACT [] synonym: "irradiation-sensitive cell" EXACT [] synonym: "neoblast compartment" EXACT [] synonym: "pASC" EXACT [] synonym: "planarian adult stem cell" EXACT [] synonym: "planarian stem cell" EXACT [] synonym: "somatic stem cell" EXACT [] xref: https://doi.org/10.1101/279364 xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000004.md xref: PMID:15866156 xref: PMID:15972844 xref: PMID:16033796 xref: PMID:16311336 xref: PMID:16344473 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17376870 xref: PMID:17390146 xref: PMID:17553481 xref: PMID:17670787 xref: PMID:17905225 xref: PMID:18063755 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:18456843 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:19174194 xref: PMID:19247960 xref: PMID:19564616 xref: PMID:19766622 xref: PMID:19805089 xref: PMID:20040488 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:20599901 xref: PMID:20844018 xref: PMID:21179477 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21356107 xref: PMID:21458439 xref: PMID:21566185 xref: PMID:21664348 xref: PMID:21747960 xref: PMID:21806978 xref: PMID:21852957 xref: PMID:21894189 xref: PMID:21937596 xref: PMID:22125640 xref: PMID:22223737 xref: PMID:22252538 xref: PMID:22252539 xref: PMID:22318224 xref: PMID:22339734 xref: PMID:22371573 xref: PMID:22385657 xref: PMID:22411224 xref: PMID:22427692 xref: PMID:22439894 xref: PMID:22445864 xref: PMID:22451003 xref: PMID:22479207 xref: PMID:22543868 xref: PMID:22549959 xref: PMID:22696458 xref: PMID:22884275 xref: PMID:22899852 xref: PMID:23079596 xref: PMID:23235145 xref: PMID:23250205 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23318641 xref: PMID:23405188 xref: PMID:23629965 xref: PMID:23903188 xref: PMID:23954785 xref: PMID:24040508 xref: PMID:24063805 xref: PMID:24120894 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24238224 xref: PMID:24367277 xref: PMID:24415944 xref: PMID:24523458 xref: PMID:24704339 xref: PMID:24737865 xref: PMID:24903754 xref: PMID:24922054 xref: PMID:24992682 xref: PMID:25017721 xref: PMID:25254346 xref: PMID:25278423 xref: PMID:25356635 xref: PMID:25956527 xref: PMID:26057828 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26459857 xref: PMID:26516985 xref: PMID:26525673 xref: PMID:26556349 xref: PMID:26618653 xref: PMID:26651295 xref: PMID:26884331 xref: PMID:27013241 xref: PMID:27063937 xref: PMID:27068018 xref: PMID:27122174 xref: PMID:27149082 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27304889 xref: PMID:27441386 xref: PMID:27501047 xref: PMID:27502555 xref: PMID:27523733 xref: PMID:27542689 xref: PMID:27551436 xref: PMID:27606067 xref: PMID:27612384 xref: PMID:27654173 xref: PMID:27864883 xref: PMID:28072387 xref: PMID:28137894 xref: PMID:28171748 xref: PMID:28216315 xref: PMID:28287248 xref: PMID:28292427 xref: PMID:28461239 xref: PMID:28686611 xref: PMID:28757112 xref: PMID:28893948 xref: PMID:29095551 xref: PMID:29100657 xref: PMID:29124009 xref: PMID:29273738 xref: PMID:29291974 xref: PMID:29364871 xref: PMID:29547123 xref: PMID:29557542 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:29906446 xref: PMID:30143032 xref: PMID:30194301 xref: PMID:30237141 xref: PMID:30282036 xref: PMID:30297872 xref: PMID:30471994 xref: PMID:30485821 xref: PMID:30729158 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000120 ! progenitor cell is_a: PLANA:0000121 ! stem cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_starts_during_or_after PLANA:0000005 ! Stage 5 relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/neoblast.png {comment="Image is an electron micrograph showing a neoblast undergoing mitotic telophase (outlined). The condensed chromatin is visible toward the left side of the cell and has been outlined by the nuclear envelope. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4705 [Term] id: PLANA:0000430 name: epithelial cell component namespace: Planarian_Anatomy def: "A part of an epithelial cell." [] is_a: BFO:0000004 ! independent continuant is_a: GO:0005575 ! cellular_component relationship: part_of PLANA:0000100 ! epithelial cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4571 [Term] id: PLANA:0000431 name: organ namespace: Planarian_Anatomy def: "Anatomical structure that performs a specific function or group of functions." [] xref: PMID:29547123 xref: UBERON:0000062 is_a: PLANA:0000427 ! multicellular anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4741 [Term] id: PLANA:0000432 name: obsolete regenerating anatomical structure comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0007567 [Term] id: PLANA:0000433 name: obsolete cellular component comment: replacing with GO term is_obsolete: true replaced_by: GO:0005575 [Term] id: PLANA:0000459 name: optic chiasm namespace: Planarian_Anatomy def: "A decussation of the diencephalon where the fibers of the optic nerve cross" [] synonym: "chiasm" EXACT [] synonym: "chiasma" EXACT [] synonym: "chiasma nervorum opticorum" EXACT [] synonym: "chiasma opticum" EXACT [] synonym: "decussation of optic nerve fibers" EXACT [] synonym: "optic chiasm (Rufus of Ephesus)" EXACT [] synonym: "optic chiasma" EXACT [] synonym: "optic chiasmata" EXACT [] xref: AAO:0010622 xref: BAMS:DC xref: BAMS:OC xref: BAMS:och xref: BAMS:ox xref: birnlex:1416 xref: BM:Tel-OCX xref: C90609 xref: DHBA:10644 xref: DMBA:17783 xref: EHDAA2:0001302 xref: EHDAA:10227 xref: EMAPA:17603 xref: FMA:62045 xref: GAID:832 xref: HBA:9310 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=459 xref: http://linkedlifedata.com/resource/umls/id/C0029126 xref: http://www.snomedbrowser.com/Codes/Details/244453006 xref: MA:0001098 xref: MBA:117 xref: MESH:D009897 xref: Optic:chiasm xref: PMID:15866156 xref: PMID:16033796 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:18202849 xref: PMID:18466009 xref: PMID:19048075 xref: PMID:19211673 xref: PMID:21282632 xref: PMID:22339734 xref: PMID:22445864 xref: PMID:25356635 xref: PMID:25493551 xref: PMID:26618653 xref: PMID:27800171 xref: PMID:28495872 xref: PMID:30194301 xref: PMID:30962434 xref: TAO:0000556 xref: UBERON:0000959 xref: UMLS:C0029126 xref: VHOG:0000190 xref: XAO:0004071 xref: ZFA:0000556 is_a: BFO:0000040 ! material entity is_a: PLANA:0000543 ! neuron projection bundle relationship: part_of PLANA:0000124 ! visual system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4735 [Term] id: PLANA:0000460 name: anterior commissure namespace: Planarian_Anatomy def: "A bundle of nerve fibers connecting the two cephalic ganglia." [] synonym: "anterior brain commissure" EXACT [] xref: UBERON:0000935 is_a: PLANA:0000494 ! brain commissure relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4427 [Term] id: PLANA:0000461 name: lateral branch namespace: Planarian_Anatomy def: "Nerve branches that extend from the lateral side of each cephalic ganglia lobe. Each lobe has nine lateral branches which terminate in sensory organs. Evidence suggests they play a role in chemosensation." [] synonym: "bilateral cephalic ganglia branch" EXACT [] synonym: "brain branch" EXACT [] synonym: "cephalic brain branch" EXACT [] synonym: "cephalic branch" EXACT [] synonym: "lateral brain branch" EXACT [] xref: ISBN:9780070316607 xref: PMID:12128224 xref: PMID:18287199 xref: PMID:18466009 xref: PMID:20422023 xref: PMID:21282632 xref: PMID:21806978 xref: PMID:24922054 xref: PMID:25254346 xref: PMID:27612384 xref: PMID:29674431 xref: PMID:30399335 xref: PMID:4452894 xref: PMID:9493832 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4651 [Term] id: PLANA:0000462 name: sensory cell namespace: Planarian_Anatomy def: "A cell that performs a sensory function." [] xref: ISBN:9780070316607 xref: PMID:17251262 xref: PMID:17942485 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4874 [Term] id: PLANA:0000463 name: cholinergic neuron namespace: Planarian_Anatomy def: "Neurons that express choline acetyltransferase." [] synonym: "acetylcholinergic neuron" EXACT [] xref: PMID:20338223 xref: PMID:21566185 xref: PMID:23652002 xref: PMID:23903188 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24950970 xref: PMID:25356635 xref: PMID:26525673 xref: PMID:27163480 xref: PMID:27612382 xref: PMID:27864883 xref: PMID:28126842 xref: PMID:28137894 xref: PMID:29291981 xref: PMID:30143032 xref: PMID:30194301 is_a: PLANA:0000556 ! neurosecretory neuron relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4486 [Term] id: PLANA:0000464 name: GABAergic neuron namespace: Planarian_Anatomy def: "Neurons that express glutamine decarboxylase." [] synonym: "GABA neuron" EXACT [] synonym: "GABAergic cell" EXACT [] synonym: "gabanergic neuron" EXACT [] synonym: "inhibitory neuron" EXACT [] xref: PMID:18440152 xref: PMID:23903188 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24922054 xref: PMID:24950970 xref: PMID:25356635 xref: PMID:26525673 xref: PMID:27864883 xref: PMID:28216315 xref: PMID:29291981 xref: PMID:30194301 xref: PMID:30485821 is_a: PLANA:0000556 ! neurosecretory neuron relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4610 [Term] id: PLANA:0000465 name: pharynx nerve plexus namespace: Planarian_Anatomy def: "Plexus of nerves located in the pharynx comprised of inner and outer wall rings." [] synonym: "nerve ganglia of pharynx" EXACT [] synonym: "neural plexus of the pharynx" EXACT [] synonym: "pharyngeal nerve plexus" EXACT [] synonym: "pharyngeal nerve ring" EXACT [] synonym: "pharyngeal nervous system" EXACT [] synonym: "pharyngeal neural plexus" EXACT [] synonym: "pharynx nerve ring" EXACT [] xref: PMID:16033796 xref: PMID:17905225 xref: PMID:20967238 xref: PMID:23250205 xref: PMID:23297191 is_a: BFO:0000040 ! material entity is_a: PLANA:0000492 ! nerve plexus relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4780 [Term] id: PLANA:0000466 name: subepidermal nerve plexus namespace: Planarian_Anatomy def: "Plexus of nerves located just between the epidermis and the body wall musculature." [] xref: doi:10.1002/jmor.1051550208 xref: PMID:27612384 is_a: BFO:0000040 ! material entity is_a: PLANA:0000492 ! nerve plexus relationship: part_of PLANA:0004529 ! integumental system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4907 [Term] id: PLANA:0000467 name: submuscular nerve plexus namespace: Planarian_Anatomy def: "Plexus of nerves that innervate the body wall musculature." [] is_a: BFO:0000040 ! material entity is_a: PLANA:0000492 ! nerve plexus relationship: part_of PLANA:0000428 ! musculature system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4908 [Term] id: PLANA:0000468 name: gastrodermal plexus namespace: Planarian_Anatomy def: "A thin net of single nerve fibers located around the gut." [] xref: doi.org/10.1002/jmor.1051550208 xref: PMID:17999079 is_a: BFO:0000040 ! material entity is_a: PLANA:0000492 ! nerve plexus relationship: part_of PLANA:0000049 ! digestive system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4616 [Term] id: PLANA:0000470 name: neuropil namespace: Planarian_Anatomy def: "A cluster of neurites that is part of a nervous system and forms a network of dendrites and axons where synapses are present and in which neuronal somata do not occur." [] synonym: "central neuropil" EXACT [] synonym: "cephalic ganglia neuropil" EXACT [] synonym: "neuropilus" EXACT [] xref: birnlex:1142 xref: BTO:0005268 xref: C12617 xref: CALOHA:TS-2403 xref: FBbt:00005139 xref: FMA:261269 xref: GAID:740 xref: http://en.wikipedia.org/wiki/Neuropil xref: http://linkedlifedata.com/resource/umls/id/C0228081 xref: http://www.snomedbrowser.com/Codes/Details/67146008 xref: MESH:D019581 xref: NIF:Subcellular\:sao205380252 xref: PMID:16033796 xref: PMID:17553481 xref: PMID:24173799 xref: PMID:24950970 xref: PMID:25356635 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:29291974 xref: PMID:29291981 xref: UBERON:0002606 xref: UMLS:C0228081 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4716 [Term] id: PLANA:0000472 name: pharynx outer epithelium namespace: Planarian_Anatomy def: "Heavily ciliated epidermal cells covering the outer surface of the pharynx shaft. These are \"insunk\" epidermal cells in which the nuclei reside behind the layers of longitudinal and circumferential muscles and the epithelial cell body sends out a ciliated projection to the surface to cover and encase the shaft." [] synonym: "epithelial pharynx lining" EXACT [] synonym: "outer pharyngeal epidermis" EXACT [] synonym: "outer pharyngeal epithelium" EXACT [] synonym: "outer pharynx epidermis" EXACT [] synonym: "outer pharynx epithelium" EXACT [] xref: ASIN:B000M4NK9M xref: PMID:29674431 is_a: BFO:0000040 ! material entity is_a: PLANA:0002023 ! ciliated epithelium relationship: immediately_superficial_to PLANA:0000476 ! pharynx outer longitudinal muscle cell relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4784 [Term] id: PLANA:0000473 name: pharynx outer circular muscle cell namespace: Planarian_Anatomy def: "Pharynx muscle fibers thar run circumferentially about the pharynx and lie just beneath the outer longitudinal pharynx muscles." [] synonym: "outer circular muscle layer" EXACT [] synonym: "pharyneal outer circular muscle fiber" EXACT [] synonym: "pharyngeal outer circular muscle cell" EXACT [] synonym: "pharynx outer circular muscle fiber" EXACT [] xref: ASIN:B000M4NK9M xref: ISBN:9780070316607 is_a: PLANA:0007535 ! pharynx circular muscle cell relationship: immediately_deep_to PLANA:0000476 ! pharynx outer longitudinal muscle cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxoutercircularmusclecell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The pharynx pouch cavity is at the top. The outer circular muscle (arrowheads) is immediately deep to the outer longitudinal muscle of the pharynx. Red = circular; blue = longitudinal. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4782 [Term] id: PLANA:0000474 name: pharynx inner circular muscle cell namespace: Planarian_Anatomy def: "Pharynx muscle fiber that runs circumferentially about the pharynx and lies just beneath the inner logitudinal pharynx muscle fibers." [] synonym: "inner circular muscle layer" EXACT [] synonym: "pharyngeal inner circular muscle cell" EXACT [] synonym: "pharyngeal inner circular muscle fiber" EXACT [] synonym: "pharynx inner circular muscle fiber" EXACT [] xref: ASIN:B000M4NK9M is_a: PLANA:0007535 ! pharynx circular muscle cell relationship: immediately_deep_to PLANA:0007534 ! pharynx inner epithelium relationship: immediately_superficial_to PLANA:0000475 ! pharynx inner longitudinal muscle cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxinnercircularmusclecell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The pharynx lumen it to the left. The inner circular muscle (arrowheads) is immediately deep to the inner epithelial layer of the pharynx. Magenta = circular; green = longitudinal; red = radial. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4770 [Term] id: PLANA:0000475 name: pharynx inner longitudinal muscle cell namespace: Planarian_Anatomy def: "Pharynx muscle fibers running anteroposterior which lie beneath both the inner circular muscle fibers and the apical, ciliated portion of the epithium lining the lumenal surface." [] synonym: "inner longitudinal muscle layer" EXACT [] synonym: "pharyngeal inner longitudinal muscle cell" EXACT [] synonym: "pharyngeal inner longitudinal muscle fiber" EXACT [] synonym: "pharynx inner longitudinal muscle fiber" EXACT [] xref: ASIN:B000M4NK9M xref: ISBN:9780070316607 is_a: PLANA:0000241 ! pharynx longitudinal muscle cell relationship: immediately_deep_to PLANA:0000474 ! pharynx inner circular muscle cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxinnerlongitudinalmusclecell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The inner longitudinal muscle (arrowheads) is immediately deep to the inner circular muscle of the pharynx. Magenta = circular; green = longitudinal; red = radial. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4774 [Term] id: PLANA:0000476 name: pharynx outer longitudinal muscle cell namespace: Planarian_Anatomy def: "Pharynx muscle fibers running anteroposterior which lie just underneath the apical, cilaited portion of the outer epithelium." [] synonym: "pharyngeal outer longitudinal muscle cell" EXACT [] synonym: "pharyngeal outer longitudinal muscle fiber" EXACT [] synonym: "pharynx outer longitudinal muscle fiber" EXACT [] xref: ASIN:B000M4NK9M is_a: PLANA:0000241 ! pharynx longitudinal muscle cell relationship: immediately_deep_to PLANA:0000472 ! pharynx outer epithelium relationship: immediately_superficial_to PLANA:0000473 ! pharynx outer circular muscle cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxouterlongitudinalmusclecell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The pharynx pouch cavity is at the top. The outer longitudinal muscle (arrowheads) is immediately deep to the outer epithelium of the pharynx. Red = circular; blue = longitudinal. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4786 [Term] id: PLANA:0000477 name: pharynx radial muscle cell namespace: Planarian_Anatomy def: "Pharynx muscle fibers that run radially, connecting the outer muscle fibers and epithelia with their inner counterparts." [] synonym: "pharyngeal radial muscle cell" EXACT [] synonym: "pharyngeal radial muscle fiber" EXACT [] synonym: "pharynx radial muscle fiber" EXACT [] synonym: "radial muscle cell" EXACT [] synonym: "radial muscle fiber" EXACT [] xref: ASIN:B000M4NK9M xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: PLANA:0000101 ! muscle cell relationship: part_of PLANA:0000478 ! pharynx musculature relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxradialmusclecell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. Immediately deep to the inner epithelial layer of the pharynx is musculature that has been colored. Magenta = circular; blue = longitudinal; yellow = radial. Scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4794 [Term] id: PLANA:0000478 name: pharynx musculature namespace: Planarian_Anatomy def: "The total musculature within the pharynx." [] synonym: "pharyngeal musculature" EXACT [] synonym: "pharynx muscle" EXACT [] synonym: "pharynx musculature" EXACT [] xref: PMID:26904543 xref: PMID:29674432 xref: SBN:9780070316607 xref: UBERON:0004467 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000016 ! pharynx relationship: part_of PLANA:0000428 ! musculature system relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4779 [Term] id: PLANA:0000479 name: pharynx inner nerve plexus namespace: Planarian_Anatomy def: "Ring of the pharynx nerve plexus that is proximal to the lumen." [] synonym: "inner pharyngeal nerve ring" EXACT [] synonym: "inner pharynx nerve ring" EXACT [] synonym: "pharynx inner nerve plexus" EXACT [] xref: ISBN:9780070316607 is_a: PLANA:0000465 ! pharynx nerve plexus relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxinnernerveplexus.png {comment="Image is an electron micrograph of a transverse section through the pharynx. Neuronal cells/tissue are marked with arrowheads. The inner nerve plexus is immediately deep to the inner longitudinal musculature. Magenta = circular; blue = longitudinal; yellow = radial. Scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4775 [Term] id: PLANA:0000480 name: pharynx outer nerve plexus namespace: Planarian_Anatomy def: "Ring of the pharynx nerve plexus that is proximal to the exterior surface." [] synonym: "outer pharyngeal nerve ring" EXACT [] synonym: "outer pharynx nerve plexus" EXACT [] synonym: "outer pharynx nerve ring" EXACT [] xref: doi:10.1002/jmor.1051550208 xref: PMID:27612384 is_a: PLANA:0000465 ! pharynx nerve plexus relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxouternerveplexus.png {comment="Image is an electron micrograph of a transverse section through the pharynx.The pharynx pouch cavity is at the top. The outer nerve plexus (arrowheads) is immediately deep to the outer circular muscle of the pharynx. Red = circular; blue = longitudinal. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4787 [Term] id: PLANA:0000481 name: serotonergic neuron namespace: Planarian_Anatomy def: "Neurons that express the neurotransmitter serotonin." [] synonym: "serotonergic cell" EXACT [] xref: PMID:23903188 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24922054 xref: PMID:24950970 xref: PMID:25356635 xref: PMID:26525673 xref: PMID:27864883 xref: PMID:28137894 xref: PMID:29357350 xref: PMID:30194301 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000556 ! neurosecretory neuron relationship: develops_from PLANA:0007550 ! serotonergic neural progenitor cell relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: part_of PLANA:0000097 ! ventral nerve cord relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4878 [Term] id: PLANA:0000482 name: dopaminergic neuron namespace: Planarian_Anatomy def: "A neuron that expresses the neurotransmitter dopamine." [] xref: PMID:17565705 xref: PMID:21458439 xref: PMID:23250205 xref: PMID:23903188 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24950970 xref: PMID:25356635 xref: PMID:27864883 xref: PMID:30194301 is_a: PLANA:0000556 ! neurosecretory neuron relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4526 [Term] id: PLANA:0000483 name: octopaminergic neuron namespace: Planarian_Anatomy def: "Neurons that express the biogenic amine octopamine." [] xref: PMID:18926867 is_a: PLANA:0000556 ! neurosecretory neuron relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4730 [Term] id: PLANA:0000484 name: secretory system namespace: Planarian_Anatomy def: "Anatomical system that has as its parts cells and glands devoted to the discharge of substances such as mucus." [] xref: PMID:20865784 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4872 [Term] id: PLANA:0000485 name: gland cell namespace: Planarian_Anatomy def: "Specialized insunk epithelial cells located in the mesenchyme that participate in mucus secretion. They are characterized by elongated cell bodies with long cytoplasmic projections that terminate between, or penetrate directly throughepithelial cells and form a secretory pore at the surface." [] synonym: "secretory gland cell" EXACT [] xref: ISBN:9780070316607 xref: PMID:19247960 xref: PMID:20865784 xref: PMID:23318635 xref: PMID:24737865 xref: PMID:28807897 xref: PMID:29674431 xref: PMID:30962434 is_a: PLANA:0000100 ! epithelial cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/glandcell.png {comment="Image is an electron micrograph depicting a portion of a gland cell (arrowheads). Note the nucleus surrounded by endoplasmic reticulum and the dark mucus granules that fill the long cytoplasmic projection. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4625 [Term] id: PLANA:0000486 name: secretory pore namespace: Planarian_Anatomy def: "The opening by which the gland cells secrete mucus to the exterior of the animal." [] synonym: "pore" EXACT [] xref: ISBN:9780070316607 xref: PMID:20865784 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0002079 ! pore relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/secretorypore.png {comment="Image is an electron micrograph of a viscid gland cell passing across the basal lamina (BL). This cell secretes a specialized type of mucus. The secretory duct transports mucus to the outside of the animal, through the secretory pore (arrowhead). Ventral is down and scale bar is 5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4871 [Term] id: PLANA:0000487 name: acidophilic gland cell namespace: Planarian_Anatomy def: "One of two distinct histochemical classes of gland cells, these can be found throughout the body but primarily form clusters of subepidermal marginal adhesive glands along the dorsoventral border of the animal." [] synonym: "eosinophilic gland cell" EXACT [] synonym: "erythrophilous gland cell" EXACT [] xref: PMID:20865784 is_a: PLANA:0000485 ! gland cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4408 [Term] id: PLANA:0000488 name: basophilic gland cell namespace: Planarian_Anatomy def: "One of two distinct histochemical classes of gland cells, these are found near the ventral mesenchyme, the pharynx and in the dorsal region of the head. May also be called cyanophilic gland cells." [] synonym: "cyanophilic gland cell" EXACT [] synonym: "cyanophilic secretory cell" EXACT [] synonym: "cyanophilous gland" EXACT [] xref: ISBN:9780070316607 xref: PMID:20865784 xref: PMID:23405188 is_a: PLANA:0000485 ! gland cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4448 [Term] id: PLANA:0000489 name: obsolete anatomical line comment: replacing with CARO term is_obsolete: true replaced_by: CARO:0000008 [Term] id: PLANA:0000490 name: obsolete anatomical plane comment: replacing with BSPO term is_obsolete: true replaced_by: BSPO:0000400 [Term] id: PLANA:0000491 name: obsolete plane of autonomy name: obsolete plane of autotomy comment: let odk import from BSPO if needed comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0035086 [Term] id: PLANA:0000492 name: nerve plexus namespace: Planarian_Anatomy def: "Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]." [] synonym: "neural network" EXACT [] synonym: "neural plexus" EXACT [] synonym: "plexus" EXACT [] xref: AEO:0000138 xref: BTO:0000205 xref: C12929 xref: EHDAA2:0003138 xref: EHDAA:3780 xref: FMA:5901 xref: http://en.wikipedia.org/wiki/Nervous\:system\:plexus xref: http://linkedlifedata.com/resource/umls/id/C0501403 xref: http://www.snomedbrowser.com/Codes/Details/122455009 xref: ISBN:9780070316607 xref: MA:0002407 xref: PMID:18202849 xref: PMID:24737865 xref: PMID:27612382 xref: PMID:29357350 xref: UBERON:0001810 xref: UMLS:C0501403 is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000080 ! peripheral nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4708 [Term] id: PLANA:0000493 name: obsolete nervous system commissure comment: we will just use commissural neuron moving forward is_obsolete: true replaced_by: PLANA:0000547 [Term] id: PLANA:0000494 name: brain commissure namespace: Planarian_Anatomy def: "any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain" [] xref: UBERON:0005970 is_a: BFO:0000040 ! material entity is_a: PLANA:0002025 ! commissure relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4457 [Term] id: PLANA:0000495 name: blastema namespace: Planarian_Anatomy def: "A regenerating tissue composed of a proliferative mass of undifferentiated progenitor cells from which new differentiated structures arise." [] synonym: "regeneration blastema" EXACT [] synonym: "regenerative blastema" EXACT [] xref: https://doi.org/10.1101/279364 xref: PMID:15866156 xref: PMID:15972844 xref: PMID:16033796 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17553481 xref: PMID:17670787 xref: PMID:17905225 xref: PMID:17942485 xref: PMID:18063755 xref: PMID:18202849 xref: PMID:18456843 xref: PMID:19048075 xref: PMID:19174194 xref: PMID:19247960 xref: PMID:19766622 xref: PMID:19852954 xref: PMID:20040488 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:20422023 xref: PMID:20599901 xref: PMID:21179478 xref: PMID:21295481 xref: PMID:21295483 xref: PMID:21356107 xref: PMID:21458439 xref: PMID:21566195 xref: PMID:21664348 xref: PMID:21806978 xref: PMID:21937596 xref: PMID:22125640 xref: PMID:22252539 xref: PMID:22318224 xref: PMID:22411224 xref: PMID:22439894 xref: PMID:22451003 xref: PMID:22479207 xref: PMID:22549959 xref: PMID:22884275 xref: PMID:22899852 xref: PMID:23235145 xref: PMID:23250205 xref: PMID:23318641 xref: PMID:23405188 xref: PMID:23629965 xref: PMID:23652002 xref: PMID:24040508 xref: PMID:24063805 xref: PMID:24120894 xref: PMID:24173799 xref: PMID:24415944 xref: PMID:24523458 xref: PMID:24704339 xref: PMID:24922054 xref: PMID:25254346 xref: PMID:25558068 xref: PMID:25725068 xref: PMID:25772472 xref: PMID:25956527 xref: PMID:26062938 xref: PMID:26459857 xref: PMID:26525673 xref: PMID:26711341 xref: PMID:26884331 xref: PMID:27013241 xref: PMID:27068018 xref: PMID:27240733 xref: PMID:27542689 xref: PMID:27551436 xref: PMID:27606067 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:28126842 xref: PMID:28137894 xref: PMID:28171748 xref: PMID:28216315 xref: PMID:28461239 xref: PMID:28757112 xref: PMID:28807897 xref: PMID:28893948 xref: PMID:29158443 xref: PMID:29273738 xref: PMID:29291974 xref: PMID:29291981 xref: PMID:29357350 xref: PMID:30194301 xref: PMID:30237141 xref: PMID:30282036 xref: PMID:30297872 xref: PMID:30471994 xref: PMID:30485821 xref: PMID:30729158 is_a: UBERON:0007567 ! regenerating anatomical structure relationship: part_of PLANA:0002133 ! regenerating fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4975 [Term] id: PLANA:0000496 name: obsolete anatomical boundary comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0000015 [Term] id: PLANA:0000497 name: obsolete anatomical junction comment: replacing with UBERON term is_obsolete: true replaced_by: UBERON:0007651 [Term] id: PLANA:0000498 name: obsolete main body axis comment: replacing duplicate PLANA term is_obsolete: true replaced_by: PLANA:0007519 [Term] id: PLANA:0000499 name: cell namespace: Planarian_Anatomy def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). xref: CALOHA:TS-2035 xref: CL:0000000 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: UBERON:0000061 ! anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4466 [Term] id: PLANA:0000500 name: obsolete cell part comment: PLANA:0000500 child terms moved to cellular component (GO:0005575) term and we think better serves interoperability and searchability is_obsolete: true replaced_by: GO:0005575 [Term] id: PLANA:0000501 name: cell projection namespace: Planarian_Anatomy def: "A prolongation or process extending from a cell." [] xref: GO:0042995 is_a: GO:0005575 ! cellular_component property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4470 [Term] id: PLANA:0000502 name: actin-based cell projection namespace: Planarian_Anatomy def: "A cell projection supported by an assembly of actin filaments." [] xref: GO:0098858 is_a: PLANA:0000501 ! cell projection property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4976 [Term] id: PLANA:0000503 name: obsolete cilium comment: inadvertently duplicated, going with ID that is best annotated is_obsolete: true replaced_by: PLANA:0002024 [Term] id: PLANA:0000504 name: microvillus namespace: Planarian_Anatomy def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments." [] xref: GO:0005902 is_a: PLANA:0000502 ! actin-based cell projection property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/microvillus.png {comment="Image is an electron micrograph depicting a portion of the outer epithelium of the pharynx. Microvilli on the left hand of the image have been labeled with arrowheads. To the right of the microvilli are larger cilia. Note the difference in width and length. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4978 [Term] id: PLANA:0000505 name: cell-cell contact zone namespace: Planarian_Anatomy def: "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions." [] xref: GO:0044291 is_a: GO:0005575 ! cellular_component property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4472 [Term] id: PLANA:0000506 name: cell junction namespace: Planarian_Anatomy def: "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [] xref: GO:0030054 xref: PMID:20511647 xref: PMID:21458439 is_a: PLANA:0000505 ! cell-cell contact zone property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/celljunction.png {comment="Image is an electron micrograph of two outer epidermal cells of the pharynx. There is an adherens junction (arrowheads) between two cells. Scale bar is 0.5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4468 [Term] id: PLANA:0000507 name: cell-cell junction namespace: Planarian_Anatomy def: "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [] xref: GO:0005911 is_a: PLANA:0000506 ! cell junction property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/cell-celljunction.png {comment="Image is an electron micrograph of two outer epidermal cells of the pharynx. There is an adherens junction (arrowheads) between two cells. Scale bar is 0.5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4473 [Term] id: PLANA:0000508 name: cell-cell adhesion namespace: Planarian_Anatomy def: "The attachment of one cell to another cell via adhesion molecules." [] xref: GO:0098609 is_a: PLANA:0000505 ! cell-cell contact zone property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/cell-celladhesion.png {comment="Image is an electron micrograph of two outer epidermal cells of the pharynx. There is an adherens junction (arrowheads) between two cells. Scale bar is 0.5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4471 [Term] id: PLANA:0000509 name: intracellular part namespace: Planarian_Anatomy def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [] xref: GO:0044424 is_a: GO:0005575 ! cellular_component property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4648 [Term] id: PLANA:0000510 name: cytoplasm namespace: Planarian_Anatomy def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures" [] xref: GO:0005737 xref: PMID:16890156 xref: PMID:28976975 is_a: PLANA:0000509 ! intracellular part property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/cytoplasm.png {comment="Image is an electron micrograph depicting a portion of a cell. Outside of the nucleus (N), the arrowheads mark areas of cytoplasm, which appears as a mottled gray filling. Scale bar is 0.5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4508 [Term] id: PLANA:0000511 name: obsolete acidophilic cytoplasm comment: term is not needed. is_obsolete: true [Term] id: PLANA:0000512 name: obsolete basophilic cytoplasm comment: term is not needed. is_obsolete: true [Term] id: PLANA:0000513 name: cytoplasmic part namespace: Planarian_Anatomy def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [] xref: GO:0044444 is_a: PLANA:0000509 ! intracellular part property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4509 [Term] id: PLANA:0000514 name: cytoplasmic vesicle part namespace: Planarian_Anatomy def: "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [] xref: GO:0044433 is_a: PLANA:0000513 ! cytoplasmic part property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4979 [Term] id: PLANA:0000515 name: vacuole namespace: Planarian_Anatomy def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [] xref: GO:0005773 is_a: PLANA:0000526 ! membrane-bounded organelle property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4982 [Term] id: PLANA:0000516 name: obsolete cytoskeleton organization comment: term is not needed. is_obsolete: true [Term] id: PLANA:0000518 name: intracellular organelle namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [] xref: GO:0043229 is_a: PLANA:0000509 ! intracellular part property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4647 [Term] id: PLANA:0000519 name: intracellular non-membrane-bounded organelle namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes" [] xref: GO:0043232 is_a: PLANA:0000518 ! intracellular organelle is_a: PLANA:0000531 ! non-membrane-bounded organelle property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4646 [Term] id: PLANA:0000520 name: membrane namespace: Planarian_Anatomy def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [] xref: GO:0016020 is_a: GO:0005575 ! cellular_component property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4687 [Term] id: PLANA:0000521 name: bounding membrane of organelle namespace: Planarian_Anatomy def: "Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes." [] xref: GO:0098588 is_a: PLANA:0000520 ! membrane property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4456 [Term] id: PLANA:0000522 name: membrane part namespace: Planarian_Anatomy def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [] xref: GO:0044425 is_a: GO:0005575 ! cellular_component relationship: part_of PLANA:0000520 ! membrane property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4688 [Term] id: PLANA:0000523 name: plasma membrane part namespace: Planarian_Anatomy def: "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [] xref: GO:0044459 is_a: PLANA:0000522 ! membrane part relationship: part_of PLANA:0007509 ! plasma membrane property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4983 [Term] id: PLANA:0000524 name: organelle membrane namespace: Planarian_Anatomy def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [] xref: GO:0031090 is_a: PLANA:0000520 ! membrane relationship: part_of PLANA:0000526 ! membrane-bounded organelle property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4980 [Term] id: PLANA:0000525 name: organelle namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [] xref: GO:0043226 is_a: GO:0005575 ! cellular_component property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4742 [Term] id: PLANA:0000526 name: membrane-bounded organelle namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [] xref: GO:0043227 is_a: PLANA:0000525 ! organelle property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4689 [Term] id: PLANA:0000527 name: intracellular membrane-bounded organelle namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [] xref: GO:0043231 is_a: PLANA:0000518 ! intracellular organelle is_a: PLANA:0000526 ! membrane-bounded organelle property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4645 [Term] id: PLANA:0000528 name: Golgi apparatus namespace: Planarian_Anatomy def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [] xref: GO:0005794 is_a: PLANA:0000527 ! intracellular membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/golgiapparatus.png {comment="Image is an electron micrograph showing golgi bodies (arrowheads). Many secretory vesicles can be seen, as well as rough endoplasmic reticulum on the right side of the micrograph. Scale bar is 0.2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4981 [Term] id: PLANA:0000529 name: nucleus namespace: Planarian_Anatomy def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [] xref: GO:0005634 xref: ISBN:9780070316607 xref: PMID:23405188 xref: PMID:25404302 xref: PMID:26457503 xref: PMID:28976975 xref: PMID:29100657 xref: PMID:29357350 is_a: PLANA:0000527 ! intracellular membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nucleus.png {comment="Image is an electron micrograph of several nuclei (N) close to and a part of the dorsal epidermis. Note how the epidermal cell nuclei appear more wrinkled and have stained differently than the cells lying beneath the basal lamina (BL). Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4728 [Term] id: PLANA:0000530 name: secretory vesicle namespace: Planarian_Anatomy def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [] xref: GO:0099503 is_a: PLANA:0000527 ! intracellular membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/secretoryvesicle.png {comment="Image is an electron micrograph depicting two golgi bodies and accompanying secratory vesicles. A few have been labeled with arrowheads. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4984 [Term] id: PLANA:0000531 name: non-membrane-bounded organelle namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [] xref: GO:0043228 is_a: PLANA:0000525 ! organelle property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4720 [Term] id: PLANA:0000532 name: nuclear part namespace: Planarian_Anatomy def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [] xref: GO:0044428 is_a: PLANA:0000509 ! intracellular part relationship: part_of PLANA:0000529 ! nucleus property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4726 [Term] id: PLANA:0000533 name: nucleolus namespace: Planarian_Anatomy def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [] xref: GO:0044428 is_a: PLANA:0000532 ! nuclear part property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nucleolus.png {comment="Image is an electron micrograph depicting a nucleus. Inside, the nucleolus has been labeled with arrowheads. Scale bar is 1 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4985 [Term] id: PLANA:0000534 name: chromatin namespace: Planarian_Anatomy def: "The ordered and organized complex of DNA, protein (histones), and sometimes RNA, that forms the chromosome." [] xref: GO:0000785 is_a: PLANA:0000532 ! nuclear part property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/chromatin.png {comment="Image is an electron micrograph showing a mitotic cell with condensed chromatin (arrowhead). Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4487 [Term] id: PLANA:0000535 name: heterochromatin namespace: Planarian_Anatomy def: "A compact and highly condensed form of chromatin." [] xref: GO:0000792 is_a: PLANA:0000534 ! chromatin property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4986 [Term] id: PLANA:0000536 name: euchromatin namespace: Planarian_Anatomy def: "A dispersed and relatively uncompacted form of chromatin." [] xref: GO:0000791 is_a: PLANA:0000534 ! chromatin property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4987 [Term] id: PLANA:0000537 name: ribosome namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [] xref: GO:0043228 is_a: PLANA:0000519 ! intracellular non-membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/ribosome.png {comment="Image is an electron micrograph depicting ribosomes (arrowheads) in two separate cells. They can be seen as small dots in the cytoplasm and associating with the rough endoplasmic reticulum in the cell in the bottom of the micrograph. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4988 [Term] id: PLANA:0000538 name: axon tract namespace: Planarian_Anatomy def: "A group of axons linking two or more neuropils and having a common origin, termination" [] synonym: "axon bundle" EXACT [] synonym: "axon bundles" EXACT [] synonym: "axon tracts" EXACT [] xref: PMID:22884275 xref: PMID:24950970UBERON\:0001018 xref: PMID:28137894 xref: UBERON:0001018 is_a: PLANA:0000113 ! tissue property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4989 [Term] id: PLANA:0000539 name: electrically responsive cell namespace: Planarian_Anatomy def: "A cell whose function is determined by its response to an electric signal." [] xref: CL:0000393 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4542 [Term] id: PLANA:0000540 name: electrically signaling cell namespace: Planarian_Anatomy def: "A cell that initiates an electrical signal and passes that signal to another cell." [] xref: CL:0000404 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4543 [Term] id: PLANA:0000541 name: nerve namespace: Planarian_Anatomy def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." [] synonym: "nerve bundle" EXACT [] synonym: "nerves" EXACT [] synonym: "neural subtree" EXACT [] synonym: "peripheral nerve" EXACT [] xref: PMID:27612382 xref: PMID:27800171 xref: UBERON:0001021 is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4707 [Term] id: PLANA:0000543 name: neuron projection bundle namespace: Planarian_Anatomy def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." [] xref: CARO:0001001 is_a: PLANA:0000538 ! axon tract relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4990 [Term] id: PLANA:0000545 name: afferent neuron namespace: Planarian_Anatomy def: "A neuron which conveys sensory information centrally from the periphery." [] synonym: "input neuron" EXACT [] xref: CL:0000526 xref: FMA:87653 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4415 [Term] id: PLANA:0000546 name: bipolar neuron namespace: Planarian_Anatomy def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [] synonym: "bipolar nerve cell" EXACT [] xref: CL:0000103 xref: FMA:67282 xref: ISBN:9780070316607 xref: PMID:16033796 xref: PMID:18202849 xref: PMID:21458439 xref: PMID:22445864 xref: PMID:24173799 xref: PMID:25493551 is_a: PLANA:0000550 ! interneuron relationship: part_of PLANA:0000466 ! subepidermal nerve plexus relationship: part_of PLANA:0000467 ! submuscular nerve plexus relationship: part_of PLANA:0007548 ! transverse commissure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4450 [Term] id: PLANA:0000547 name: commissural neuron namespace: Planarian_Anatomy def: "A neuron that has an axon which crosses the midline." [] xref: CL:0000678 xref: PMID:22339734 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4991 [Term] id: PLANA:0000548 name: efferent neuron namespace: Planarian_Anatomy def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [] synonym: "output neuron" EXACT [] xref: CL:0000527 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000080 ! peripheral nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4540 [Term] id: PLANA:0000549 name: excitatory motor neuron namespace: Planarian_Anatomy def: "A motor neuron that is capable of directly inducing muscle contraction." [] comment: In vertebrates, all motor neurons are excitatory, but various types of inhibitory motor neurons exist in invertebrates. synonym: "excitatory neuron" EXACT [] xref: CL:0008014 xref: PMID:25356635 is_a: PLANA:0000553 ! motor neuron is_a: PLANA:0000564 ! peripheral nervous system neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4992 [Term] id: PLANA:0000550 name: interneuron namespace: Planarian_Anatomy def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [] xref: BTO:0003811 xref: CL:0000099 xref: FBbt:00005125 xref: FMA:67313 xref: WBbt:0005113 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4642 [Term] id: PLANA:0000552 name: sensory neuron namespace: Planarian_Anatomy def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [] xref: BTO:0001037 xref: CL:0000101 xref: FBbt:00005124 xref: FMA:84649 xref: WBbt:0005759 is_a: PLANA:0000462 ! sensory cell is_a: PLANA:0000545 ! afferent neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4875 [Term] id: PLANA:0000553 name: motor neuron namespace: Planarian_Anatomy def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [] synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: CL:0000100 xref: FMA:83617 xref: WBbt:0005409 is_a: PLANA:0000548 ! efferent neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4697 [Term] id: PLANA:0000556 name: neurosecretory neuron namespace: Planarian_Anatomy def: "Neuronal cells which synthesize, store and release neurohormones." [] synonym: "neurosecretory cell" EXACT [] xref: CL:0000381 xref: FBbt:00005130 xref: PMID:24173799 is_a: PLANA:0000099 ! neuron is_a: PLANA:0000105 ! secretory cell relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4717 [Term] id: PLANA:0000558 name: sympathetic neuron namespace: Planarian_Anatomy def: "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." [] xref: CL:0011103 is_a: PLANA:0000099 ! neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4993 [Term] id: PLANA:0000559 name: unipolar neuron namespace: Planarian_Anatomy def: "Neuron with one neurite that extends from the cell body." [] synonym: "unipolar nerve cell" EXACT [] xref: CL:0000106 xref: FMA:67278 xref: ISBN:9780070316607 xref: PMID:18499291 xref: PMID:24173799 is_a: PLANA:0000552 ! sensory neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4947 [Term] id: PLANA:0000560 name: multipolar neuron namespace: Planarian_Anatomy def: "Neuron with an axon and two or more dendrites." [] synonym: "multipolar nerve cell" EXACT [] xref: CL:0000104 xref: FMA:67287 xref: ISBN:9780070316607 xref: PMID:18499291 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000103 ! central nervous system relationship: part_of PLANA:0000466 ! subepidermal nerve plexus property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4701 [Term] id: PLANA:0000561 name: neuron associated cell (sensu Nematoda and Protostomia) namespace: Planarian_Anatomy def: "Cells that are in close proximity to neurons." [] xref: CL:0000130 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4714 [Term] id: PLANA:0000562 name: central nervous system neuron namespace: Planarian_Anatomy def: "Any neuron that is part of a central nervous system." [] xref: CL:2000029 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4476 [Term] id: PLANA:0000564 name: peripheral nervous system neuron namespace: Planarian_Anatomy def: "Any neuron that is part of a peripheral nervous system." [] synonym: "peripheral neuron" EXACT [] xref: CL:2000032 xref: PMID:23123964 xref: PMID:23954785 xref: PMID:25254346 xref: PMID:26711341 xref: PMID:29184198 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000080 ! peripheral nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4763 [Term] id: PLANA:0000565 name: autonomic neuron namespace: Planarian_Anatomy def: "A neruon whose cell body is within an autonomic ganglion." [] xref: CL:0000107 xref: FMA:80121 is_a: PLANA:0000564 ! peripheral nervous system neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4443 [Term] id: PLANA:0000566 name: enteric neuron namespace: Planarian_Anatomy def: "A neruon whose cell body is within an autonomic ganglion." [] xref: CL:0007011 is_a: PLANA:0000565 ! autonomic neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4994 [Term] id: PLANA:0001005 name: basal lamina of epithelium namespace: Planarian_Anatomy def: "Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue." [] comment: this class represents a continuous sheet of basal lamina which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal lamina' represents a portion of substance on the scale of a single cell. synonym: "basal lamina" EXACT [] synonym: "basement membrane" EXACT [] xref: CARO:0000065 xref: ISBN:9780070316607 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:21664348 xref: PMID:21828097 xref: PMID:22479207 xref: PMID:23079596 xref: PMID:23405188 xref: PMID:23903188 xref: PMID:25017721 xref: PMID:26057828 xref: PMID:26457503 xref: PMID:27551436 xref: PMID:29100657 xref: PMID:30383829 xref: PMID:30962434 is_a: UBERON:0000476 ! acellular anatomical structure relationship: immediately_deep_to PLANA:0000034 ! epidermis relationship: part_of PLANA:0004529 ! integumental system property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/basallamina.png {comment="Image is an electron micrograph showing the dorsal epidermis. Epidermal cells can be seen above (superfical to) the basal lamina (BL) and the body wall musculature can be seen below. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4995 [Term] id: PLANA:0002000 name: adenal rhabdite namespace: Planarian_Anatomy def: "Rhabdites that are located basally to the epidermis, in the mesenchyme. In Smed these are present in cells likely on their way to becoming part of the mature epidermis." [] xref: ISBN:9780070316607 is_a: PLANA:0000104 ! rhabdite relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/adenalrhabdite.png {comment="Image is an electron micrograph showing the dorsal epidermis and underlying basal lamina at the top. Adenal rhabdites are marked with \"Rh\" and can be seen in cells underneath or medial to the basal lamina. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4409 [Term] id: PLANA:0002001 name: adherens junction namespace: Planarian_Anatomy def: "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [] xref: GO:0005912 xref: PMID:26556349 is_a: PLANA:0000506 ! cell junction relationship: part_of PLANA:0000508 ! cell-cell adhesion property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/adherensjunction.png {comment="Image is an electron micrograph of two outer epidermal cells of the pharynx. There is an adherens junction (arrowheads) between two cells. Scale bar is 0.5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4410 [Term] id: PLANA:0002002 name: adhesive papilla namespace: Planarian_Anatomy def: "Finger-like processes at the terminal pore of adhesive gland cells around the marginal adhesive zone. They protrude past the epidermis and are longer microvilli, and shorter than cilia." [] synonym: "adhesive papillae" EXACT [] xref: ISBN:9780070316607 is_a: BFO:0000040 ! material entity is_a: PLANA:0000501 ! cell projection relationship: part_of PLANA:0007540 ! viscid gland cell relationship: part_of PLANA:0007541 ! releasing gland cell relationship: RO:0001018 PLANA:0000043 ! contained in dorsal ventral margin of the whole animal relationship: RO:0001018 PLANA:0002054 ! contained in marginal adhesive zone relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/adhesivepapilla.png {comment="Image is an electron micrograph of the outside of an animal at the marginal adhesive zone. The adhesive papilla (arrowheads) are colored in blue and surround each secretory pore (yellow). Mucus and cilia are both green. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4413 [Term] id: PLANA:0002003 name: amputation namespace: Planarian_Anatomy def: "A wound resulting in two or more separate tissue fragments." [] is_a: PLANA:0002026 ! cut property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4416 [Term] id: PLANA:0002004 name: anterior gut branch namespace: Planarian_Anatomy def: "A branch of the triclad gut located anterior to the pharynx." [] synonym: "anterior branch" EXACT [] synonym: "anterior intestinal branch" EXACT [] xref: PMID:18063757 xref: PMID:18287199 xref: PMID:19174194 xref: PMID:20707997 xref: PMID:21458439 xref: PMID:21664348 xref: PMID:21806978 xref: PMID:22451003 xref: PMID:22479207 xref: PMID:23318635 xref: PMID:24063805 xref: PMID:28287248 xref: PMID:30194301 is_a: BFO:0000040 ! material entity is_a: PLANA:0002119 ! gut branch relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4430 [Term] id: PLANA:0002005 name: anterior tip namespace: Planarian_Anatomy def: "The anterior-medial region of the head margin." [] synonym: "head tip" EXACT [] xref: PMID:15866156 xref: PMID:18063755 xref: PMID:22479207 xref: PMID:24415944 xref: PMID:24992682 xref: PMID:27063937 xref: PMID:28126842 xref: PMID:28216315 xref: PMID:29547123 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: PLANA:0000102 ! anatomical region relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4437 [Term] id: PLANA:0002006 name: antrum namespace: Planarian_Anatomy def: "A chamber formation in an organ." [] xref: ISBN:9780070316607 xref: NCIT:C97102 is_a: UBERON:0002553 ! anatomical cavity property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4439 [Term] id: PLANA:0002007 name: auricle namespace: Planarian_Anatomy def: "A sense organ located along the dorsolateral head margin. The auricular groove is highly innervtated by ciliated sensory neurons, and has an altered epidermis devoid of rhabdites and gland cells." [] xref: ISBN:9780070316607 xref: PMID:27800171 xref: PMID:28495872 xref: PMID:30399335 xref: PMID:30485821 is_a: BFO:0000040 ! material entity is_a: PLANA:0000431 ! organ relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000125 ! sensory system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/auricles.png {comment="Image is a scanning electron micrograph of the dorsal side of the head of an adult worm. The auricles (arrowheads) appear as a short groove on each side of the head. Anteror is down and scale bar is 100um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4442 [Term] id: PLANA:0002008 name: axon namespace: Planarian_Anatomy def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [] synonym: "nerve fiber" EXACT [] xref: GO:0030424 xref: PMID:16033796 xref: PMID:17251262 xref: PMID:17553481 xref: PMID:18202849 xref: PMID:20707997 xref: PMID:21566185 xref: PMID:22445864 xref: PMID:23318641 xref: PMID:23903188 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25493551 xref: PMID:25772472 xref: PMID:27800171 xref: PMID:28495872 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000501 ! cell projection relationship: part_of PLANA:0002061 ! neurite relationship: specific_to PLANA:0000099 ! neuron property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/axon.png {comment="Image is an electron micrograph showing a cross section of an axon (arrowheads), right underneath or medial to the dorsal body wall musculature. Dorsal is up and the scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4444 [Term] id: PLANA:0002009 name: axoneme namespace: Planarian_Anatomy def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [] xref: GO:0005930 xref: PMID:23144623 xref: PMID:26057828 xref: PMID:26912790 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000519 ! intracellular non-membrane-bounded organelle relationship: part_of PLANA:0002024 ! cilium relationship: part_of PLANA:0002040 ! flagellum property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/axoneme.png {comment="Image is an electron micrograph of several cilia where a cross-section reveals the axoneme with a 9+2 arrangement of microtubles. Arrowheads denote microtubules. Scale bar is 100nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4445 [Term] id: PLANA:0002010 name: basal body namespace: Planarian_Anatomy def: "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [] xref: GO:0036064 xref: ISBN:9780070316607 xref: PMID:21282632 xref: PMID:21828097 xref: PMID:21937596 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000519 ! intracellular non-membrane-bounded organelle relationship: part_of PLANA:0002024 ! cilium relationship: part_of PLANA:0002040 ! flagellum property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/basalbody.png {comment="Image is an electron micrograph showing a cross-section of a cilium, revealing the basal body (arrowhead). Scale bar is 0.5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4446 [Term] id: PLANA:0002011 name: brain visual center namespace: Planarian_Anatomy def: "Region of the cephalic ganglia innervated by the optic nerve (posterior-projecting photoreceptor neuron fasiculated axons)." [] synonym: "visual center" EXACT [] xref: PMID:16033796 xref: PMID:26618653 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: part_of PLANA:0000124 ! visual system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4458 [Term] id: PLANA:0002012 name: bulbar cavity namespace: Planarian_Anatomy def: "An enlarged portion of the seminal vesicle, comprised of secretory epithelial cells, that connects to the ejaculatory duct within the penis papilla." [] synonym: "bulbar lumen" EXACT [] xref: https://doi.org/10.1101/279364 xref: ISBN:9780070316607 is_a: BFO:0000040 ! material entity is_a: UBERON:0002553 ! anatomical cavity relationship: part_of PLANA:0000234 ! seminal vesicle relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4459 [Term] id: PLANA:0002013 name: Category 1 cell namespace: Planarian_Anatomy def: "Irradiation-sensitive, mesenchymal cells that are absent from the head region anterior to the eyes and the pharynx. The Category 1 designation encompasses the neoblast population." [] synonym: "Category 1 gene expressing cell" EXACT [] xref: PMID:18786419 xref: PMID:21894189 xref: PMID:22439894 is_a: BFO:0000040 ! material entity is_a: PLANA:0002095 ! somatic cell is_a: PLANA:0003116 ! parenchymal cell relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4461 [Term] id: PLANA:0002014 name: cell body namespace: Planarian_Anatomy def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [] xref: GO:0044297 xref: PMID:15866156 xref: PMID:16033796 xref: PMID:20865784 xref: PMID:27612384 xref: PMID:28495872 is_a: GO:0005575 ! cellular_component property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4467 [Term] id: PLANA:0002015 name: cephalic ganglia lobe namespace: Planarian_Anatomy def: "One of two bilaterally symmetric structures comprising the planarian brain." [] synonym: "bi-lobed brain" EXACT [] synonym: "bi-lobed cephalic ganglia" EXACT [] synonym: "brain" EXACT [] synonym: "brain ganglia" EXACT [] synonym: "brain lobe" EXACT [] xref: ISBN:9780070316607 xref: PMID:15866156 xref: PMID:16033796 xref: PMID:16890156 xref: PMID:17251262 xref: PMID:17553481 xref: PMID:17670787 xref: PMID:17905225 xref: PMID:17999079 xref: PMID:18063757 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:19211673 xref: PMID:19247960 xref: PMID:19766622 xref: PMID:19852954 xref: PMID:20223763 xref: PMID:20422023 xref: PMID:20707997 xref: PMID:20967238 xref: PMID:21179478 xref: PMID:21282632 xref: PMID:21566185 xref: PMID:21806978 xref: PMID:21828097 xref: PMID:21852957 xref: PMID:22074376 xref: PMID:22125640 xref: PMID:22318224 xref: PMID:22371573 xref: PMID:22427692 xref: PMID:22439894 xref: PMID:22445864 xref: PMID:22451003 xref: PMID:22479207 xref: PMID:22884275 xref: PMID:23123964 xref: PMID:23250205 xref: PMID:23297191 xref: PMID:23318635 xref: PMID:23652002 xref: PMID:23903188 xref: PMID:24040508 xref: PMID:24063805 xref: PMID:24120894 xref: PMID:24131630 xref: PMID:24173799 xref: PMID:24238224 xref: PMID:24523458 xref: PMID:24704339 xref: PMID:24950970 xref: PMID:24992682 xref: PMID:25017721 xref: PMID:25254346 xref: PMID:25356635 xref: PMID:25493551 xref: PMID:25558068 xref: PMID:25772472 xref: PMID:26062938 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26525673 xref: PMID:26556349 xref: PMID:26618653 xref: PMID:27013241 xref: PMID:27034770 xref: PMID:27063937 xref: PMID:27074666 xref: PMID:27149082 xref: PMID:27150006 xref: PMID:27163480 xref: PMID:27523733 xref: PMID:27606067 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:27800171 xref: PMID:27864883 xref: PMID:28126842 xref: PMID:28137894 xref: PMID:28171748 xref: PMID:28245923 xref: PMID:28287248 xref: PMID:28434803 xref: PMID:28686611 xref: PMID:28807897 xref: PMID:28893948 xref: PMID:29100657 xref: PMID:29158443 xref: PMID:29291974 xref: PMID:29291981 xref: PMID:29357350 xref: PMID:29547123 xref: PMID:29557542 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:30143032 xref: PMID:30194301 xref: PMID:30282036 xref: PMID:30383829 xref: PMID:30399335 xref: PMID:30485821 xref: PMID:30729158 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: existence_starts_during_or_after PLANA:0000006 ! Stage 6 relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4478 [Term] id: PLANA:0002016 name: cephalic ganglia neuron namespace: Planarian_Anatomy def: "A central nervous system neuron located within the planarian brain." [] synonym: "brain neuron" EXACT [] xref: PMID:17999079 xref: PMID:24173799 xref: PMID:27612382 is_a: BFO:0000040 ! material entity is_a: PLANA:0000562 ! central nervous system neuron relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4479 [Term] id: PLANA:0002017 name: chemical amputation namespace: Planarian_Anatomy def: "Amputation carried out by application of chemicals." [] xref: PMID:24737865 is_a: PLANA:0002108 ! wound property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4482 [Term] id: PLANA:0002018 name: chemical pharynx amputation namespace: Planarian_Anatomy def: "Amputation of the phaynx, including the esophagus, by treatment with Sodium Azide." [] synonym: "chemical pharyngeal amputation" EXACT [] xref: PMID:24737865 is_a: PLANA:0002017 ! chemical amputation property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4483 [Term] id: PLANA:0002019 name: chemosensory neuron namespace: Planarian_Anatomy def: "Any neuron that capable of some detection of chemical stimulus involved in sensory perception." [] synonym: "chemoreceptive neuron" EXACT [] synonym: "chemoreceptor neuron" EXACT [] xref: FBbt:00005922 xref: PMID:18202849 xref: PMID:26525673 xref: PMID:27612382 xref: PMID:28126842 xref: PMID:28686611 xref: PMID:29547123 is_a: PLANA:0000552 ! sensory neuron relationship: part_of PLANA:0000125 ! sensory system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4485 [Term] id: PLANA:0002020 name: chromatoid body namespace: Planarian_Anatomy def: "A membrane-less, cytoplasmic ribonucleoprotein granule present in neoblasts and germ cells implicated in post-transcriptional regulation. The RNA helicase DHH1/RCK, Tudor, SmB, methylated substrates of PRMT5, PIWI-3 and Germinal Histone H4 localize to chromatoid bodies in neoblasts." [] synonym: "nuage" EXACT [] xref: PMID:19247960 xref: PMID:20215344 xref: PMID:21356107 xref: PMID:22318224 xref: PMID:22385657 xref: PMID:22439894 xref: PMID:22543868 xref: PMID:24120894 xref: PMID:24367277 xref: PMID:24903754 xref: PMID:25017721 xref: PMID:27523733 is_a: PLANA:0000531 ! non-membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/chromatoidbody.png {comment="Image is an electron micrograph showing a chromatoid body (arrowhead) next to the cell's nucleus (N) which takes up the bottom left corner. Scale bar is 200nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4488 [Term] id: PLANA:0002021 name: chromosome namespace: Planarian_Anatomy def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [] xref: GO:0005694 xref: PMID:25404302 xref: PMID:28757112 xref: PMID:28812561 xref: PMID:29364871 xref: PMID:30143032 is_a: PLANA:0000531 ! non-membrane-bounded organelle is_a: PLANA:0000532 ! nuclear part property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/chromosome.png {comment="Image is an electron micrograph showing a mitotic cell. An arrowhead marks the long arm of a chromosome. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4490 [Term] id: PLANA:0002022 name: chromosome arm namespace: Planarian_Anatomy def: "Under the microscope chromosomes appear as thin, thread-like structures. They all have a short arm and long arm separated by a primary constriction called the centromere. The short arm is designated as p and the long arm as q." [] xref: NCIT:C13355 xref: PMID:25404302 is_a: PLANA:0000532 ! nuclear part relationship: part_of PLANA:0002021 ! chromosome property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/chromosomearm.png {comment="Image is an electron micrograph showing a mitotic cell. An arrowhead marks the long arm of a chromosome. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4491 [Term] id: PLANA:0002023 name: ciliated epithelium namespace: Planarian_Anatomy def: "Epithelium bearing vibratile cilia on the free surface." [] xref: PMID:26457503 xref: PMID:26711341 xref: PMID:28216315 xref: PMID:28292427 xref: UBERON:0007601 is_a: PLANA:0002118 ! epithelium property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/ciliatedepithelialcell.png {comment="Image is an electron micrograph of an outer epidermal cell of the pharynx. These cells are heavily ciliated. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4494 [Term] id: PLANA:0002024 name: cilium namespace: Planarian_Anatomy def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. The longitudinal array of microtubules are almost always in a 9+2 array with 2 microtubles in the central cilia bundle and 9 sets of doublet microtubules around the perimeter. The exception to this arrangement is spermatazoa flagella, which have a 9+1 array in planarians." [] xref: GO:0005929 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000501 ! cell projection relationship: part_of PLANA:0000106 ! ciliated epithelial cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/cilium.png {comment="Image is an electron micrograph depicting several cilia (arrowheads) emerging from a ventral epidermis cell. Scale bar is 0.5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4495 [Term] id: PLANA:0002025 name: commissure namespace: Planarian_Anatomy def: "A bundle of nerve fibers crossing from one side to the other side of the brain or spinal cord." [] xref: NCIT:C32349 is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4502 [Term] id: PLANA:0002026 name: cut namespace: Planarian_Anatomy def: "A wound or cleft resulted from tissue separation into parts or laid open or penetrated with a sharp edge or instrument." [] xref: NCIT:C50518 is_a: PLANA:0002099 ! surgical wound property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4507 [Term] id: PLANA:0002027 name: dendrite namespace: Planarian_Anatomy def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [] synonym: "cell dendrite" EXACT [] synonym: "dendritic process" EXACT [] synonym: "dendritic projection" EXACT [] xref: GO:0030425 xref: PMID:16033796 xref: PMID:17553481 xref: PMID:22445864 xref: PMID:25493551 xref: PMID:28495872 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000501 ! cell projection relationship: part_of PLANA:0002061 ! neurite relationship: specific_to PLANA:0000099 ! neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4514 [Term] id: PLANA:0002028 name: dorsal-ventral muscle cell namespace: Planarian_Anatomy def: "A muscle cell that runs in the transverse plane that connects the dorsal and ventral sides of the animal." [] synonym: "dorsal-ventral muscle" EXACT [] synonym: "dorsal-ventral muscle fibers" EXACT [] synonym: "dorsoventral muscle" EXACT [] synonym: "dorsoventralmuscle fibers" EXACT [] synonym: "DVM" EXACT [] xref: PMID:30471994 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: PLANA:0000101 ! muscle cell relationship: part_of PLANA:0000079 ! parenchymal musculature relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/dorsal-ventralmusclecell.png {comment="Image is an electron micrograph depicting multiple dorsal-ventral muscle cells (arrowheads). The ventral epidermis is at the bottom of this image. Scale bar is 10um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4536 [Term] id: PLANA:0002029 name: early female germ cell namespace: Planarian_Anatomy def: "A premeiotic female germ cell (i.e., a diploid female germline stem cell or transit amplifying oogonial cell)." [] is_a: BFO:0000040 ! material entity is_a: PLANA:0000229 ! female germ cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000204 ! ovary relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4537 [Term] id: PLANA:0002030 name: early male germ cell namespace: Planarian_Anatomy def: "A premeiotic male germ cell (i.e., a spermatogonial stem cell or transit amplifying spermatogonial cell)." [] xref: PMID:27330085 is_a: BFO:0000040 ! material entity is_a: PLANA:0000228 ! male germ cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000208 ! testis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4538 [Term] id: PLANA:0002031 name: embryonic gut namespace: Planarian_Anatomy def: "A cryptic digestive cavity comprised of phagocytic embryonic gut cells." [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: PLANA:0002120 ! extraembryonic organ relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000004 ! Stage 4 relationship: part_of PLANA:0000058 ! embryonic digestive system relationship: RO:0001018 PLANA:0000041 ! contained in aboral hemisphere relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4548 [Term] id: PLANA:0002032 name: epidermal cell namespace: Planarian_Anatomy def: "An epithelial cell of the integument (the outer layer of an organism)." [] xref: CL:0000362 xref: PMID:21458439 xref: PMID:24922054 xref: PMID:25017721 xref: PMID:26457503 xref: PMID:28292427 xref: PMID:28686611 xref: PMID:28807897 xref: PMID:29100657 xref: PMID:29357350 xref: PMID:30399335 is_a: PLANA:0000100 ! epithelial cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/epidermalcell.png {comment="Image is an electron micrograph depicting the dorsal epidermis. A single cell has been labeled with arrowheads. Immediately deep to the epidermis is the basal lamina, labeled with \"BL.\" Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4565 [Term] id: PLANA:0002033 name: epidermal rhabdite namespace: Planarian_Anatomy def: "Rhabdites located within epidermal cells." [] xref: ISBN:9780070316607 is_a: PLANA:0000104 ! rhabdite relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/epidermalrhabdite.png {comment="Image is an electron micrograph depicting the epidermis. Rhabdites (arrowheads) can be seen in various stages of expansion inside of the epidermal cells. Scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4568 [Term] id: PLANA:0002034 name: ER membrane namespace: Planarian_Anatomy def: "The lipid bilayer surrounding the endoplasmic reticulum." [] xref: GO:0005789 is_a: PLANA:0000521 ! bounding membrane of organelle relationship: part_of PLANA:0007513 ! endoplasmic reticulum property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/ermembrane.png {comment="Image is an electron micrograph depicting (rough) endoplasmic reticulum adjacent tp the nucleus (N). The arrowheads mark the ER membrane. Note the ribosomes (small dots) that can be seen both in the cytoplasm and lining the ER membrane. Scale bar is 0.2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4573 [Term] id: PLANA:0002035 name: eumelanin namespace: Planarian_Anatomy def: "The black pigment that gives non-neuronal pigment cells of the optic cup their characteristic color." [] synonym: "eye cell pigment" EXACT [] synonym: "eye pigment" EXACT [] xref: CHEBI:24009 xref: PMID:15760337 xref: PMID:25356635 xref: PMID:26017970 xref: PMID:27240733 xref: PMID:8812261 is_a: BFO:0000004 ! independent continuant is_a: GO:0005575 ! cellular_component relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0002058 ! melanosome relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4575 [Term] id: PLANA:0002036 name: excretory cell namespace: Planarian_Anatomy def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [] xref: CL:0000424 xref: PMID:21566185 xref: PMID:24173799 is_a: PLANA:0000119 ! terminally differentiated cell relationship: part_of PLANA:0000088 ! renal system property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/excretorycell.png {comment="Image is an electron micrograph showing a cell that is part of the collecting duct. An arrowhead marks the nucleus of this cell. Note the visible lumen of the collecting duct extending out and passing through the basal lamina. This cell is involved in excretion. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4576 [Term] id: PLANA:0002037 name: extracellular matrix namespace: Planarian_Anatomy def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [] synonym: "ECM" EXACT [] xref: GO:0031012 xref: PMID:19048075 xref: PMID:28126842 xref: PMID:28137894 xref: PMID:28807897 xref: PMID:30962434 is_a: UBERON:0000476 ! acellular anatomical structure relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/extracellularmatrix.png {comment="Image is an electron micrograph showing the extracellular matrix (arrowheads) between two cells. Scale bar is 0.2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4578 [Term] id: PLANA:0002038 name: extracellular space namespace: Planarian_Anatomy def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [] xref: GO:0005615 xref: PMID:21828097 is_a: UBERON:0000476 ! acellular anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4580 [Term] id: PLANA:0002039 name: fission namespace: Planarian_Anatomy def: "A form of asexual reproduction resulting in self-amputation of posterior tissue, generating an anterior fragment and a fission fragment." [] is_a: PLANA:0002108 ! wound property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4590 [Term] id: PLANA:0002040 name: flagellum namespace: Planarian_Anatomy def: "Planarian undulipodia consisting of spermatazoa cell posterior protrusions. Planarian spermatozoa contain two flagella and are composed of 9 + 1 axonemal microtubule arrangements in their flagella (markedly different from the 9 + 2 structures generally observed in sperm of other animals)." [] xref: PMID:29095551 xref: PMID:4190073 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000501 ! cell projection relationship: part_of PLANA:0000090 ! sperm relationship: specific_to PLANA:0000090 ! sperm property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4593 [Term] id: PLANA:0002041 name: gap junction namespace: Planarian_Anatomy def: "A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins." [] xref: GO:0005921 xref: PMID:17670787 xref: PMID:22125640 is_a: PLANA:0000507 ! cell-cell junction property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4614 [Term] id: PLANA:0002042 name: genital atrium namespace: Planarian_Anatomy def: "A chamber where egg capsules are formed. One or more zygotes and yolk cells produced by the vitelline glands collect in the genital atrium; glands surrounding the genital atrium produce the egg capsule shell." [] synonym: "atrium" EXACT [] synonym: "female antrum" EXACT [] xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: UBERON:0002553 ! anatomical cavity relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000126 ! reproductive system relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4621 [Term] id: PLANA:0002043 name: germ cell cyst namespace: Planarian_Anatomy def: "A clonally-related group of interconnected spermatogonial or oogonial cells, enveloped by somatic gonadal cells." [] synonym: "germ cell cluster" EXACT [] xref: PMID:17376870 xref: PMID:22318224 is_a: PLANA:0002090 ! reproductive structure is_a: PLANA:0002136 ! syncytium relationship: part_of PLANA:0000217 ! gonad relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4623 [Term] id: PLANA:0002044 name: germline stem cell namespace: Planarian_Anatomy def: "Stem cell that is the precursor of gametes." [] synonym: "germ cell" EXACT [] synonym: "germ stem cell" EXACT [] synonym: "germline cell" EXACT [] xref: FBbt:00004861 xref: https://doi.org/10.1101/279364 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:17390146 xref: PMID:18456843 xref: PMID:19247960 xref: PMID:20215344 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:22252538 xref: PMID:22318224 xref: PMID:22385657 xref: PMID:22543868 xref: PMID:23652002 xref: PMID:24173799 xref: PMID:24367277 xref: PMID:25278423 xref: PMID:27013241 xref: PMID:28434803 xref: PMID:28812561 is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000121 ! stem cell relationship: develops_from PLANA:0000429 ! neoblast relationship: part_of PLANA:0000217 ! gonad relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4624 [Term] id: PLANA:0002045 name: glycogen granule namespace: Planarian_Anatomy def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [] xref: GO:0042587 xref: PMID:30608231 is_a: PLANA:0002137 ! intracellular granule property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/glycogengranule.png {comment="Image is an electron micrograph depicting glycogen granules (arrowheads) within the cytoplasm of a cell. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4627 [Term] id: PLANA:0002046 name: incision namespace: Planarian_Anatomy def: "A breach of the epidermis made with a defined edge or point." [] is_a: PLANA:0002026 ! cut property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4637 [Term] id: PLANA:0002047 name: pharynx inner epidermal cell namespace: Planarian_Anatomy def: "Epithelial cells lining the inside of the pharynx. In Smed, distally located cells are heavily ciliated." [] synonym: "inner pharynx epidermal cell" EXACT [] xref: ISBN:9780070316607 xref: PMID:20511647 is_a: BFO:0000040 ! material entity is_a: PLANA:0000106 ! ciliated epithelial cell is_a: PLANA:0002032 ! epidermal cell relationship: part_of PLANA:0004528 ! pharynx epithelium relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxinnerepidermalcell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The phayrnx lumen is to the bottom left. An epidermal cell, a part of the inner epithelial layer, has been marked with arrowheads. Immediately deep to the inner epithelial layer of the pharynx is musculature that has been colored. Magenta = circular; blue = longitudinal; yellow = radial. Scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4771 [Term] id: PLANA:0002048 name: inner zone of gland cells namespace: Planarian_Anatomy def: "Gland or secretory cells sandwiched between muscle and epidermal layers in the pharynx." [] xref: ISBN:9780070316607 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/innerzoneofglandcells.png {comment="Image is an electron micrograph depicting a transverse section through the pharynx. Arrowheads label the inner zone of gland cells. They can be identified by the mucus granules the cell body is filled with. Scale bar is 5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4639 [Term] id: PLANA:0002049 name: intercellular junction namespace: Planarian_Anatomy def: "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [] xref: GO:0005911 is_a: PLANA:0000507 ! cell-cell junction property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4641 [Term] id: PLANA:0002050 name: linear amputation namespace: Planarian_Anatomy def: "An amputation performed with a transverse, oblique or longitudinal cut." [] is_a: PLANA:0002003 ! amputation property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4655 [Term] id: PLANA:0002051 name: linear incision namespace: Planarian_Anatomy def: "A breach of the epidermis and optionally down into other structures though an insult with a knife or other instrument, such that the movement includes the z direction and one or more of the x y direction." [] synonym: "scratch" EXACT [] is_a: PLANA:0002046 ! incision property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4656 [Term] id: PLANA:0002052 name: lipid droplet namespace: Planarian_Anatomy def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [] xref: GO:0005811 xref: https://doi.org/10.1101/279364 xref: PMID:30608231 is_a: PLANA:0000519 ! intracellular non-membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/lipiddroplet.png {comment="Image is an electron micrograph depicting two lipid droplets (arrowheads) within two different cells. Note the mostly round shape of the droplets. Often, mitochondria can be seen clumped around lipids. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4657 [Term] id: PLANA:0002053 name: lumen namespace: Planarian_Anatomy def: "The cavity or channel within a tube or tubular organ such as a blood vessel or the intestine." [] xref: NCIT:C94478 is_a: UBERON:0002553 ! anatomical cavity property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4663 [Term] id: PLANA:0002054 name: marginal adhesive zone namespace: Planarian_Anatomy def: "Zone present along the lateral dorsoventral boundary that sits just underneath the animal, in contact with substrates. It is comprised of bunches of adhesion gland cells whose terminal pores form pore rosettes through the dorsal ventral boundary epidermis.This region of is devoid of rhabdites." [] xref: ISBN:9780070316607 xref: PMID:20865784 is_a: BSPO:0000086 ! anatomical compartment relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/marginaladhesivezone.png {comment="Image is an electron micrograph depicting the lateral dorsoventral boundary. Several adhesion gland cells have been labeled with arrowheads to visualize the line of the marginal adhesive zone. Scale bar is 10um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4667 [Term] id: PLANA:0002055 name: mechanosensory neuron namespace: Planarian_Anatomy def: "Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception." [] synonym: "mechanosensory cell" EXACT [] xref: FBbt:00005919 xref: PMID:25725068 xref: PMID:28216315 is_a: PLANA:0000552 ! sensory neuron relationship: part_of PLANA:0000125 ! sensory system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4669 [Term] id: PLANA:0002056 name: medial muscle cell namespace: Planarian_Anatomy def: "Subset of dorsal-ventral muscle cells located in the medial body region." [] xref: PMID:29674431 xref: PMID:30962434 is_a: BFO:0000040 ! material entity is_a: PLANA:0000101 ! muscle cell relationship: part_of PLANA:0000079 ! parenchymal musculature relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/medialmusclecell.png {comment="Image is an electron micrograph depicting multiple medial dorsal-ventral muscle cells (arrowheads). At the bottom of this image is the ventral epidermi, to the left is the dark staining of the gut tissue. Scale bar is 10um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4670 [Term] id: PLANA:0002057 name: meiotic germ cell namespace: Planarian_Anatomy def: "A germ cell undergoing meiosis." [] xref: PMID:27330085 is_a: PLANA:0000227 ! germ cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4677 [Term] id: PLANA:0002058 name: melanosome namespace: Planarian_Anatomy def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [] xref: GO:0042470 is_a: BFO:0000040 ! material entity is_a: PLANA:0000527 ! intracellular membrane-bounded organelle relationship: existence_starts_during_or_after PLANA:0000007 ! Stage 7 relationship: part_of PLANA:0000031 ! pigment cup cell relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4686 [Term] id: PLANA:0002059 name: mucus namespace: Planarian_Anatomy def: "A secreted, mucin-rich extracellular substance coating the epidermal surface of the animal implicated in gliding locomotion, substrate adhesion, innate immunity and predator avoidance." [] xref: PMID:21282632 xref: PMID:22653920 is_a: BFO:0000040 ! material entity is_a: UBERON:0000476 ! acellular anatomical structure relationship: part_of PLANA:0000484 ! secretory system relationship: produced_by PLANA:0000105 ! secretory cell relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/mucus.png {comment="Image is an electron micrograph of the outside of an animal at the marginal adhesive zone. The adhesive papilla are colored in blue and surround each secretory pore (yellow). Mucus (arrowheads) and cilia are both green. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4699 [Term] id: PLANA:0002060 name: nephridiopore namespace: Planarian_Anatomy def: "The external opening and terminus of a protonephridium made by a terminal cell." [] xref: ISBN:9780070316607 xref: PMID:21828097 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0002079 ! pore relationship: part_of PLANA:0000065 ! flame cell property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nephridiopore.png {comment="Image is an electron micrograph depicting a collecting duct (arrowheads) passing through the basal lamina (BL). Dorsal is up and the scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4706 [Term] id: PLANA:0002061 name: neurite namespace: Planarian_Anatomy def: "Cell appendage of the neuron which includes the axon and the dendrite." [] synonym: "neuronal process" EXACT [] xref: FMA:61814 xref: ISBN:9780070316607 xref: PMID:27612382 xref: PMID:29547123 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000501 ! cell projection relationship: part_of PLANA:0000099 ! neuron relationship: specific_to PLANA:0000099 ! neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4712 [Term] id: PLANA:0002062 name: neuropeptidergic neuron namespace: Planarian_Anatomy def: "A neuron that produces and releases neuropeptides at chemical synapses." [] synonym: "cns peptidergic cell" EXACT [] synonym: "peptidergic neuron" EXACT [] xref: PMID:24173799 xref: PMID:25356635 xref: PMID:27163480 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4715 [Term] id: PLANA:0002063 name: non-ciliated epidermis namespace: Planarian_Anatomy def: "Differentiating, immature epidermal cells lacking cilia." [] xref: PMID:26457503 xref: PMID:28292427 is_a: PLANA:0000034 ! epidermis property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4719 [Term] id: PLANA:0002064 name: nuclear envelope namespace: Planarian_Anatomy def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [] xref: GO:0005635 xref: https://doi.org/10.1101/279364 is_a: PLANA:0000520 ! membrane property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nuclearenvelope.png {comment="Image is an electron micrograph depicting the nuclear envelope (arrowheads). The nucleus takes up the top left corner of the image and the nuclear envelope encloses it. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4722 [Term] id: PLANA:0002065 name: nuclear inner membrane namespace: Planarian_Anatomy def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [] synonym: "inner leaflet" EXACT [] xref: GO:0005637 is_a: PLANA:0000522 ! membrane part relationship: part_of PLANA:0002064 ! nuclear envelope property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nuclearinnermembrane.png {comment="Image is an electron micrograph depicting the nuclear envelope. The nucleus takes up the top left corner of the image and the inner nuclear membrane has been labeled with arrowheads. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4723 [Term] id: PLANA:0002066 name: nuclear lumen namespace: Planarian_Anatomy def: "The volume enclosed by the nuclear inner membrane." [] xref: GO:0031981 is_a: PLANA:0000532 ! nuclear part property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4724 [Term] id: PLANA:0002067 name: nuclear outer membrane namespace: Planarian_Anatomy def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [] synonym: "outer leaflet" EXACT [] xref: GO:0005640 is_a: PLANA:0000522 ! membrane part relationship: part_of PLANA:0002064 ! nuclear envelope property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nuclearoutermembrane.png {comment="Image is an electron micrograph depicting the nuclear envelope. The nucleus takes up the top left corner of the image and the outer nuclear membrane has been labeled with arrowheads. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4725 [Term] id: PLANA:0002068 name: nuclear periphery namespace: Planarian_Anatomy def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [] xref: GO:0034399 xref: PMID:25404302 is_a: PLANA:0000532 ! nuclear part property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4727 [Term] id: PLANA:0002069 name: ommochrome pigment cell namespace: Planarian_Anatomy def: "Parenchymal cells that synthesize and contain brown ommonchrome pigment." [] synonym: "non-melanin pigment cell" EXACT [] xref: PMID:27240733 is_a: BFO:0000040 ! material entity is_a: PLANA:0002075 ! pigment cell relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4731 [Term] id: PLANA:0002070 name: optic nerve namespace: Planarian_Anatomy def: "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila." [] xref: PMID:27800171 xref: UBERON:0004904 is_a: BFO:0000040 ! material entity is_a: PLANA:0000541 ! nerve relationship: part_of PLANA:0000124 ! visual system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4738 [Term] id: PLANA:0002071 name: pharynx outer epidermal cell namespace: Planarian_Anatomy def: "Heavily ciliated, insunk epithelial cells bounding the outside of the pharynx. Outer pharynx epithelial cell nuclei are positioned beneath the pharynx musculature." [] synonym: "outer pharynx epidermal cell" EXACT [] xref: ISBN:9780070316607 xref: PMID:20511647 is_a: BFO:0000040 ! material entity is_a: PLANA:0000106 ! ciliated epithelial cell is_a: PLANA:0002032 ! epidermal cell relationship: part_of PLANA:0004528 ! pharynx epithelium relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxouterepidermalcell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The pharynx pouch cavity is at the top. An epidermal cell, a part of the outer epithelium, has been labeled with arrowheads. Immediately deep to the outer epithelial layer of the pharynx is musculature that has been colored. Red = circular; blue = longitudinal. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4783 [Term] id: PLANA:0002073 name: phagocytic cell namespace: Planarian_Anatomy def: "A cell that engulfs large particles or cells via invagination of the plasma membrane and creation of a phagosome." [] synonym: "phagocyte" EXACT [] xref: ISBN:9780070316607 xref: PMID:25956527 xref: PMID:27501047 xref: PMID:30471994 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4765 [Term] id: PLANA:0002074 name: pharynx tip namespace: Planarian_Anatomy def: "The distal-most end of the pharnyx containing an opening to the pharynx lumen." [] is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult relationship: specific_to PLANA:0000016 ! pharynx property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxtip.png {comment="Image is an electron micrograph of the tip of the pharynx. Many gland cells can be seen inside, filled with mucus. Scale bar is 5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4795 [Term] id: PLANA:0002075 name: pigment cell namespace: Planarian_Anatomy def: "A pigment cell is a cell that contains pigment granules." [] synonym: "pigment producing cell" EXACT [] synonym: "pigmented cell" EXACT [] xref: CL:0000147 xref: PMID:26618653 is_a: PLANA:0000119 ! terminally differentiated cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4797 [Term] id: PLANA:0002076 name: pigment granule namespace: Planarian_Anatomy def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [] xref: GO:0048770 xref: ISBN:9780070316607 xref: PMID:27551436 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000526 ! membrane-bounded organelle relationship: part_of PLANA:0002075 ! pigment cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4800 [Term] id: PLANA:0002077 name: plug amputation namespace: Planarian_Anatomy def: "An amputation of tissue, usually though the whole depth of the animal encompassing both dorsal and ventral sides, often made with a biopsy punch." [] is_a: PLANA:0002003 ! amputation property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4802 [Term] id: PLANA:0002078 name: point incision namespace: Planarian_Anatomy def: "A breach of the epidermis made with a defined edge or point." [] synonym: "poke" EXACT [] is_a: PLANA:0002046 ! incision property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4804 [Term] id: PLANA:0002079 name: pore namespace: Planarian_Anatomy def: "An anatomical space that is an opening, usually at the end of a canal or duct, on the surface of the integument or the lining of an internal anatomical space." [] xref: UBERON:0008915 is_a: UBERON:0002553 ! anatomical cavity property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4805 [Term] id: PLANA:0002080 name: post-meiotic germ cell namespace: Planarian_Anatomy def: "A haploid gamete undergoing terminal differentiation." [] is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000227 ! germ cell relationship: develops_from PLANA:0002082 ! premeiotic germ cell relationship: part_of PLANA:0000204 ! ovary relationship: part_of PLANA:0000208 ! testis relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4807 [Term] id: PLANA:0002081 name: postsynaptic cell namespace: Planarian_Anatomy def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [] synonym: "post-synaptic cell" EXACT [] xref: GO:0045211 xref: PMID:24950970 is_a: PLANA:0000499 ! cell relationship: part_of PLANA:0000025 ! nervous system relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4814 [Term] id: PLANA:0002082 name: premeiotic germ cell namespace: Planarian_Anatomy def: "A diploid germline stem cell or transit amplifying germ cell that has not committed to undergoing meiotic DNA replication, reductive divisions or terminal differentiation." [] is_a: PLANA:0000227 ! germ cell relationship: part_of PLANA:0000204 ! ovary relationship: part_of PLANA:0000208 ! testis relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4815 [Term] id: PLANA:0002083 name: presynaptic cell namespace: Planarian_Anatomy def: "The part of a synapse that is part of the presynaptic cell." [] synonym: "pre-synaptic cell" EXACT [] xref: GO:0098793 xref: PMID:24950970 is_a: PLANA:0000099 ! neuron relationship: part_of PLANA:0000025 ! nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4818 [Term] id: PLANA:0002084 name: presynaptic terminal namespace: Planarian_Anatomy def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [] synonym: "pre-synaptic terminal" EXACT [] xref: GO:0043195 xref: PMID:23903188 is_a: BFO:0000004 ! independent continuant is_a: GO:0005575 ! cellular_component relationship: part_of PLANA:0002008 ! axon relationship: part_of PLANA:0002083 ! presynaptic cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4819 [Term] id: PLANA:0002085 name: presynaptic vesicle namespace: Planarian_Anatomy def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [] synonym: "pre-synaptic vesicle" EXACT [] xref: GO:0008021 xref: PMID:23903188 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000526 ! membrane-bounded organelle relationship: part_of PLANA:0002083 ! presynaptic cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4820 [Term] id: PLANA:0002086 name: primary gut branch namespace: Planarian_Anatomy def: "The largest branch of the triclad intestine. It is comprised of the gastrodermis, a columnar epithelium, surrounded by basal lamina and visceral musculature." [] synonym: "main gut branch" EXACT [] synonym: "primary intestine branch" EXACT [] xref: PMID:17553481 xref: PMID:20865784 xref: PMID:21664348 xref: PMID:27122174 xref: PMID:28137894 xref: PMID:29674431 is_a: PLANA:0002119 ! gut branch property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4821 [Term] id: PLANA:0002087 name: primitive gut namespace: Planarian_Anatomy def: "Four large phagocytic cells associated with the embryonic pharynx." [] synonym: "primitive endoderm" EXACT [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: PLANA:0002120 ! extraembryonic organ relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: part_of PLANA:0000058 ! embryonic digestive system relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4825 [Term] id: PLANA:0002088 name: quarternary gut branch namespace: Planarian_Anatomy def: "Gut branches originating from and connected to the tertiary gut branches." [] xref: PMID:21664348 is_a: PLANA:0002119 ! gut branch property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4843 [Term] id: PLANA:0002089 name: reproductive organ namespace: Planarian_Anatomy def: "An organ involved in reproduction" [] xref: https://doi.org/10.1101/279364 xref: PMID:16344473 xref: PMID:17376870 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:25278423 xref: PMID:27074666 xref: UBERON:0003133 is_a: PLANA:0000431 ! organ relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000126 ! reproductive system relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4849 [Term] id: PLANA:0002090 name: reproductive structure namespace: Planarian_Anatomy def: "Any anatomical structure that is part of the reproductive system." [] xref: PMID:17376870 xref: UBERON:0005156 is_a: UBERON:0000061 ! anatomical structure relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4850 [Term] id: PLANA:0002091 name: rhabdome namespace: Planarian_Anatomy def: "The light sensing structure consisting of photoreceptor neuron dendrites that project into the optic lumen and show close associations with eumelanin-containing pigment cup cells." [] xref: PMID:15760337 xref: PMID:16033796 xref: PMID:21852957 xref: PMID:26017970 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000036 ! eye relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4854 [Term] id: PLANA:0002092 name: rhabdomere namespace: Planarian_Anatomy def: "The dendritic process of a bipolar photoreceptor neuron that projects into the optic cup lumen and senses light." [] xref: PMID:15760337 xref: PMID:16033796 xref: PMID:18202849 xref: PMID:20865784 xref: PMID:21282632 xref: PMID:21852957 xref: PMID:22445864 xref: PMID:25772472 xref: PMID:26618653 xref: PMID:27800171 is_a: BFO:0000040 ! material entity is_a: PLANA:0000501 ! cell projection relationship: part_of PLANA:0000017 ! photoreceptor neuron relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4855 [Term] id: PLANA:0002093 name: secretory duct namespace: Planarian_Anatomy def: "A tubular structure that transports secreted or excreted substances." [] synonym: "secretory canal" EXACT [] xref: PMID:30383829 xref: UBERON:0000058 is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000484 ! secretory system relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/secretoryduct.png {comment="Image is an electron micrograph of a viscid gland cell passing across the basal lamina (BL). This cell secretes a specialized type of mucus. The secretory duct (arrowhead) transports mucus to the outside of the animal, through the secretory pore. Ventral is down and scale bar is 5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4869 [Term] id: PLANA:0002094 name: secretory granule namespace: Planarian_Anatomy def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [] xref: GO:0030141 xref: PMID:29100657 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000526 ! membrane-bounded organelle relationship: part_of PLANA:0000105 ! secretory cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4870 [Term] id: PLANA:0002095 name: somatic cell namespace: Planarian_Anatomy def: "One of the cells of the body that compose the tissues, organs, and parts of that individual other than the germ cells." [] xref: BTO:0001268 xref: PMID:20599901 xref: PMID:21852957 xref: PMID:22074376 xref: PMID:22371573 xref: PMID:22385657 xref: PMID:25404302 xref: PMID:27606067 xref: PMID:28757112 is_a: PLANA:0000499 ! cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4882 [Term] id: PLANA:0002096 name: somatic gonadal cell namespace: Planarian_Anatomy def: "A non-germline cell within the ovary or testis." [] synonym: "gonadal niche cell" EXACT [] synonym: "somatic gonadal niche cell" EXACT [] synonym: "somatic gonadal support cell" EXACT [] xref: PMID:27163480 xref: PMID:27330085 is_a: PLANA:0000119 ! terminally differentiated cell relationship: part_of PLANA:0000217 ! gonad property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4883 [Term] id: PLANA:0002097 name: specialized neoblast namespace: Planarian_Anatomy def: "A presumptive progenitor cell that expresses both pan-neoblast markers and pro-differentiation gene(s), frequently developmental transcription factors, implicated in lineage commitment and tissue-specific differentiation programs." [] xref: PMID:23404104 xref: PMID:25254346 xref: PMID:26651295 xref: PMID:27542689 xref: PMID:29674432 xref: PMID:30962434 is_a: PLANA:0000429 ! neoblast property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4884 [Term] id: PLANA:0002098 name: stalk namespace: Planarian_Anatomy def: "A thin, flexible rod that anchors an egg capsule to a solid substrate." [] xref: ISBN:9780070316607 is_a: BFO:0000040 ! material entity is_a: UBERON:0000476 ! acellular anatomical structure relationship: part_of PLANA:0000216 ! egg capsule relationship: produced_by PLANA:0000224 ! cement gland relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4905 [Term] id: PLANA:0002099 name: surgical wound namespace: Planarian_Anatomy def: "A wound produced by non-autonomous physical means." [] is_a: PLANA:0002108 ! wound property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4909 [Term] id: PLANA:0002100 name: synapse namespace: Planarian_Anatomy def: "The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [] synonym: "neural synapse" EXACT [] synonym: "neuronal synapse" EXACT [] xref: GO:0045202 xref: PMID:18202849 xref: PMID:18287199 xref: PMID:21282632 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000507 ! cell-cell junction relationship: part_of PLANA:0000099 ! neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4910 [Term] id: PLANA:0002101 name: synaptic cleft namespace: Planarian_Anatomy def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [] xref: GO:0043083 xref: PMID:23903188 is_a: PLANA:0002038 ! extracellular space relationship: part_of PLANA:0000099 ! neuron relationship: part_of PLANA:0000539 ! electrically responsive cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4911 [Term] id: PLANA:0002102 name: synaptic vesicle namespace: Planarian_Anatomy def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [] xref: GO:0008021 xref: PMID:24950970 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000526 ! membrane-bounded organelle relationship: part_of PLANA:0000099 ! neuron property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4912 [Term] id: PLANA:0002103 name: synaptonemal complex namespace: Planarian_Anatomy def: "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [] xref: GO:0000795 xref: PMID:25404302 is_a: PLANA:0002123 ! chromosomal_structural_element relationship: specific_to PLANA:0002057 ! meiotic germ cell property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4913 [Term] id: PLANA:0002104 name: tail tip namespace: Planarian_Anatomy def: "The posterior-medial region of the tail margin." [] is_a: BFO:0000040 ! material entity is_a: PLANA:0000102 ! anatomical region relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4918 [Term] id: PLANA:0002105 name: telomere namespace: Planarian_Anatomy def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [] xref: GO:0000781 xref: https://doi.org/10.1101/279364 xref: PMID:22371573 xref: PMID:25404302 is_a: PLANA:0002121 ! chromosome_part relationship: part_of PLANA:0002022 ! chromosome arm property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4919 [Term] id: PLANA:0002106 name: septate junction namespace: Planarian_Anatomy def: "A cell-cell junction in invertebrates that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [] xref: GO:0070160 is_a: BFO:0000004 ! independent continuant is_a: PLANA:0000507 ! cell-cell junction relationship: part_of PLANA:0002118 ! epithelium property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/septatejunction.png {comment="Image is an electron micrograph depicting the inner epithelium of the pharynx. Septate junctions (arrowheads) can be clearly seen between cells. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4938 [Term] id: PLANA:0002107 name: wedge amputation namespace: Planarian_Anatomy def: "A piece of tissue removed from the lateral margin at any given point that extendes interiorly to more medial structures." [] is_a: PLANA:0002003 ! amputation property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4960 [Term] id: PLANA:0002108 name: wound namespace: Planarian_Anatomy def: "An injury that breaches the epidermis." [] synonym: "injury" EXACT [] is_a: PLANA:0002122 ! perturbation property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4963 [Term] id: PLANA:0002109 name: X1 cell namespace: Planarian_Anatomy def: "A sorted cell population enriched for irradiation-sensitive, cycling cells (4n cells, with high levels of Hoescht 33342 staining) with scant cytoplasm (low levels of calcein-AM staining). X1 cells are enriched for cycling neoblasts." [] synonym: "X1" EXACT [] synonym: "X1 cell population" EXACT [] synonym: "X1 neoblast" EXACT [] synonym: "X1 population" EXACT [] xref: PMID:16872450 xref: PMID:17670787 xref: PMID:18456843 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:21937596 xref: PMID:22385657 xref: PMID:22427692 xref: PMID:22543868 xref: PMID:22549959 xref: PMID:23235145 xref: PMID:23629965 xref: PMID:24120894 xref: PMID:24367277 xref: PMID:24992682 xref: PMID:25254346 xref: PMID:25558068 xref: PMID:25956527 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26711341 xref: PMID:27013241 xref: PMID:27068018 xref: PMID:27150006 xref: PMID:27502555 xref: PMID:27523733 xref: PMID:27551436 xref: PMID:28137894 xref: PMID:29100657 xref: PMID:29557542 xref: PMID:29674432 xref: PMID:29906446 xref: PMID:30194301 is_a: PLANA:0000499 ! cell is_a: PLANA:0002138 ! FACS sorted cell population property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4964 [Term] id: PLANA:0002110 name: X1(FS) cell namespace: Planarian_Anatomy def: "A heterogeneous sorted cell population of unstained planarian cells with similar size and complexity to irradiation-sensitive, cycling cells contained in the X1 gate. Unlike X1 cells, X1(FS) cells are amenable to cell transplantation." [] xref: PMID:21566185 is_a: PLANA:0000499 ! cell is_a: PLANA:0002138 ! FACS sorted cell population property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4965 [Term] id: PLANA:0002111 name: X2 cell namespace: Planarian_Anatomy def: "A sorted cell population containing irradiation-sensitive and irradiation-insensitive cells, characterized by weak Hoescht 33342 and calcein-AM staining. X2 cell populations contain neoblasts as well as a variety of lineage-dedicated post-mitotic progenitor cells." [] xref: PMID:16872450 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:22427692 xref: PMID:22543868 xref: PMID:23629965 xref: PMID:24367277 xref: PMID:25017721 xref: PMID:27013241 xref: PMID:27150006 xref: PMID:27502555 xref: PMID:27606067 xref: PMID:27864883 xref: PMID:28137894 xref: PMID:29674432 is_a: PLANA:0000499 ! cell is_a: PLANA:0002138 ! FACS sorted cell population property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4966 [Term] id: PLANA:0002112 name: Xins cell namespace: Planarian_Anatomy def: "A sorted cell population of irradiation-insensitive cells that contains a variety of post-mitotic, differentiated cell types." [] synonym: "Xins" EXACT [] synonym: "Xins cell population" EXACT [] synonym: "Xins cells" EXACT [] xref: PMID:16872450 xref: PMID:17670787 xref: PMID:18456843 xref: PMID:18786419 xref: PMID:19048075 xref: PMID:20215344 xref: PMID:20223763 xref: PMID:22427692 xref: PMID:22479207 xref: PMID:22543868 xref: PMID:23629965 xref: PMID:24367277 xref: PMID:24992682 xref: PMID:25558068 xref: PMID:25956527 xref: PMID:26114597 xref: PMID:26457503 xref: PMID:26711341 xref: PMID:27013241 xref: PMID:27502555 xref: PMID:29100657 xref: PMID:29674432 xref: PMID:29906446 xref: PMID:30194301 is_a: PLANA:0000499 ! cell is_a: PLANA:0002138 ! FACS sorted cell population property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4967 [Term] id: PLANA:0002113 name: post-pharyngeal region namespace: Planarian_Anatomy def: "Posterior to the pharynx." [] synonym: "post pharyngeal" EXACT [] synonym: "post-pharyngeal" EXACT [] synonym: "postpharyngeal region" EXACT [] is_a: BFO:0000040 ! material entity is_a: PLANA:0000102 ! anatomical region relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4808 [Term] id: PLANA:0002114 name: post-blastema region namespace: Planarian_Anatomy def: "Adjacent to blastema, or proximal to blastema." [] synonym: "post-blastema" EXACT [] synonym: "postblastema" EXACT [] synonym: "postblastema region" EXACT [] is_a: BSPO:0000070 ! anatomical region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4806 [Term] id: PLANA:0002116 name: fission fragment namespace: Planarian_Anatomy def: "A fragment derived from a spontaneous or induced fission event." [] is_a: PLANA:0002128 ! fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4591 [Term] id: PLANA:0002118 name: epithelium namespace: Planarian_Anatomy def: "The avascular cellular layers that cover body surfaces and cavities and may form glands." [] xref: NCIT:C12710 is_a: PLANA:0000113 ! tissue property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/epithelium.png {comment="Image is an electron micrograph of a transverse section of a planarian through the pharyngeal region depicting 3 different epithelial layers (arrowheads). At the top is the dorsal epidermis, in the middle is the epithelium of the pharyngeal pouch, and at the bottom of the image, the outer epithelium of the pharynx. Scale bar is 5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4572 [Term] id: PLANA:0002119 name: gut branch namespace: Planarian_Anatomy def: "The triclad planarian gut is serially bifrucated into connected lumens where each bifrucation is a branch." [] is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000026 ! gut relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4633 [Term] id: PLANA:0002120 name: extraembryonic organ namespace: Planarian_Anatomy def: "Organ that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [] is_a: PLANA:0000431 ! organ relationship: part_of PLANA:0000116 ! embryo relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4582 [Term] id: PLANA:0002121 name: chromosome_part namespace: Planarian_Anatomy def: "This is a manufactured term, that serves the purpose of allow the parts of a chromosome to have an is_a path to the root." [] xref: SO:0000830 is_a: PLANA:0000532 ! nuclear part relationship: part_of PLANA:0002021 ! chromosome property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4492 [Term] id: PLANA:0002122 name: perturbation namespace: Planarian_Anatomy def: "An event or occurrence that causes damage to a tissue or organ." [] synonym: "insult" EXACT [] property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4764 [Term] id: PLANA:0002123 name: chromosomal_structural_element namespace: Planarian_Anatomy def: "structural element of a chromosome, for example, a telomere and a centromere" [] synonym: "chromosomal structural element" EXACT [] xref: SO:0000628 is_a: PLANA:0002121 ! chromosome_part property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4489 [Term] id: PLANA:0002125 name: thick fragment namespace: Planarian_Anatomy def: "A longitudinal fragment containing the preexisting midline and medial structures." [] is_a: PLANA:0003608 ! longitudinal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4935 [Term] id: PLANA:0002126 name: thin fragment namespace: Planarian_Anatomy def: "A longitudinal fragment lacking a midline and medial structures." [] is_a: PLANA:0003608 ! longitudinal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4937 [Term] id: PLANA:0002128 name: fragment namespace: Planarian_Anatomy def: "A piece of tissue isolated from the body." [] synonym: "piece" EXACT [] is_a: UBERON:0007567 ! regenerating anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4597 [Term] id: PLANA:0002129 name: longitudinal region namespace: Planarian_Anatomy def: "A region bounded by any sagittal plane though the animal and the left or right side of the animal. NOTE: sagittal plane is an anatomical plane that divides a bilateral body into left and right parts, not necessarily of even size" [] is_a: BSPO:0000070 ! anatomical region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4662 [Term] id: PLANA:0002130 name: chemical wound namespace: Planarian_Anatomy def: "An intentional wound produced by non-autonomous chemical means." [] is_a: PLANA:0002108 ! wound property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4484 [Term] id: PLANA:0002131 name: plug wound namespace: Planarian_Anatomy def: "A wound resulting from the removal of tissue, usually though the whole depth of the animal encompassing both dorsal and ventral sides, often made with a biopsy punch." [] is_a: PLANA:0002108 ! wound property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4803 [Term] id: PLANA:0002132 name: wedge wound namespace: Planarian_Anatomy def: "A wound resulting from the removal of a piece of tissue from the lateral margin at any given point that extends interiorly to more medial structures." [] is_a: PLANA:0002108 ! wound property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4961 [Term] id: PLANA:0002133 name: regenerating fragment namespace: Planarian_Anatomy def: "A fragment that has undergone wound healing and is undergoing tissue replacement and morphallaxis." [] is_a: PLANA:0002128 ! fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4845 [Term] id: PLANA:0002134 name: sagittal orientation namespace: Planarian_Anatomy def: "An orientation quality inhering in a bearer by virtue of the bearer having a position that is in the sagittal plane. This plane runs longitudinally and is not necessarily medial." [] synonym: "longitudinal orientation" EXACT [] is_a: PATO:0005024 ! longitudinal orientation property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4863 [Term] id: PLANA:0002135 name: parasagittal orientation namespace: Planarian_Anatomy def: "An orientation quality inhering in a bearer by virtue of the bearer having a position that is in the parasagittal plane, which runs longitudinally, and is never medial." [] xref: PATO:0005023 is_a: PLANA:0002134 ! sagittal orientation property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4755 [Term] id: PLANA:0002136 name: syncytium namespace: Planarian_Anatomy def: "An anatomical entity consisting of a single or a few multinucleated structures" [] xref: AEO:0000203 xref: PMID:27330085 is_a: UBERON:0000061 ! anatomical structure property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4914 [Term] id: PLANA:0002137 name: intracellular granule namespace: Planarian_Anatomy def: "Cytoplasmic part which forms a distinctive granular particle, which may or may not be visible using light microscopy." [] xref: MICRO:0000215 is_a: PLANA:0000519 ! intracellular non-membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/intracellulargranule.png {comment="Image is an electron micrograph depicting a cell with many intracellular granules (arrowheads) visible in the cytoplasm. The scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4644 [Term] id: PLANA:0002138 name: FACS sorted cell population namespace: Planarian_Anatomy def: "Any number of cells from dissociated planarian tissue sorted via a FACS sorter for any parameter." [] is_a: PLANA:0002139 ! derived cell population property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4587 [Term] id: PLANA:0002139 name: derived cell population namespace: Planarian_Anatomy def: "Cells isolated from dissociated planarian tissue." [] is_a: UBERON:0000465 ! material anatomical entity property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4515 [Term] id: PLANA:0002140 name: pharynx pouch epithelium namespace: Planarian_Anatomy def: "An epithelial monolayer lining the pharynx pouch cavity." [] xref: OCLC:16809160 is_a: BFO:0000040 ! material entity is_a: PLANA:0002118 ! epithelium relationship: part_of PLANA:0000081 ! pharynx pouch relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxpouchepithelium.png {comment="Image is an electron micrograph of a transverse slice through the parapharyngeal region. It includes the dorsal epidermis, pharynx pouch epithelium (arrowheads), and a portion of the pharynx. Dorsal is up and the lumen of the pouch is visible as the white stripe in the middle of the micrograph. Scale bar is 5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4792 [Term] id: PLANA:0002141 name: sperm duct epithelial surface namespace: Planarian_Anatomy def: "Epithelial surface lining the sperm duct." [] is_a: BSPO:0000005 ! anatomical surface relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: immediately_superficial_to PLANA:0004531 ! sperm duct lumen relationship: part_of PLANA:0004533 ! sperm duct epithelium relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4889 [Term] id: PLANA:0002142 name: parenchyma namespace: Planarian_Anatomy def: "A loosely organized collection of connective tissue and cells, including neoblasts and their immediate progeny, located in the space outside of the organs between the body wall musculature and the gut." [] synonym: "mesenchyme" EXACT [] xref: OCLC:16809160 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4756 [Term] id: PLANA:0003000 name: dorsal region of tail namespace: Planarian_Anatomy def: "The dorsal region of the tail." [] synonym: "dorsal region of tail" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000079 ! dorsal region intersection_of: part_of PLANA:0000421 ! tail relationship: has_component BSPO:0000079 ! dorsal region relationship: part_of PLANA:0000421 ! tail property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003100 name: testis cell namespace: Planarian_Anatomy def: "cell which is part of the testis" [PMID:29674431] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003101 name: ventral epidermis cell namespace: Planarian_Anatomy def: "cell which is part of the ventral epidermis" [PMID:22479207, PMID:23144623] synonym: "ventral ciliated cell" EXACT [] synonym: "ventral epithelial cell" EXACT [] synonym: "ventral motile ciliated cell" EXACT [] synonym: "ventral multiciliated cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003102 name: visual system cell namespace: Planarian_Anatomy def: "cell which is part of the visual system" [PMID:17905225, PMID:24922054] synonym: "visual cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003103 name: eye cell namespace: Planarian_Anatomy def: "cell which is part of the eye" [PMID:29357350] synonym: "photoreceptor cell" EXACT [] synonym: "photosensitive cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003104 name: enteric muscle cell namespace: Planarian_Anatomy def: "cell which is part of the enteric musculature" [PMID:23954785, PMID:25558068] synonym: "gut muscle cell" EXACT [] synonym: "intestinal muscle cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003105 name: dorsal epidermis cell namespace: Planarian_Anatomy def: "cell which is part of the dorsal region of the epidermis" [PMID:22479207] synonym: "dorsal epithelial cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003106 name: adhesion gland cell namespace: Planarian_Anatomy def: "cell which is part of the adhesion gland" [PMID:16890156, PMID:28976975] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003107 name: body wall muscle cell namespace: Planarian_Anatomy def: "cell which is part of the body wall musculature" [PMID:23954785, PMID:24992682, PMID:25254346, PMID:25725068, PMID:26525673] synonym: "body wall muscle fiber" EXACT [] synonym: "body-wall muscle cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003108 name: gastrodermal cell namespace: Planarian_Anatomy def: "cell which is part of the gastrodermis" [PMID:19174194, PMID:22479207, PMID:27122174] synonym: "gut cell" EXACT [] synonym: "intestinal cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003109 name: anterior pole cell namespace: Planarian_Anatomy def: "cell which is part of the anterior pole" [PMID:24992682, PMID:29674431, PMID:30471994] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003110 name: pharynx neuron namespace: Planarian_Anatomy def: "neuron which is part of the pharynx" [PMID:18202849, PMID:29674431, PMID:30485821] synonym: "pharyngeal neuron" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003111 name: pharynx epithelial cell namespace: Planarian_Anatomy def: "epithelial cell which is part of the pharynx" [PMID:20511647] synonym: "pharynx epithelial cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003112 name: pharynx muscle cell namespace: Planarian_Anatomy def: "muscle cell which is part of the pharynx" [PMID:27068018] synonym: "pharynx muscle fiber" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003113 name: pharynx pouch epithelial cell namespace: Planarian_Anatomy def: "epithelial cell which is part of the pharynx pouch" [] synonym: "pharyngeal cavity epithelial cell" EXACT [] synonym: "pharynx cavity epithelial cell" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003114 name: melanin pigment granule namespace: Planarian_Anatomy def: "pigment granule which is part of the eumelanin" [PMID:25356635, PMID:26017970, PMID:27551436] synonym: "melanin" EXACT [] synonym: "melanosome" EXACT [] synonym: "photoreceptor pigment" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003115 name: ommochrome pigment granule namespace: Planarian_Anatomy def: "pigment granule which is part of the ommochrome pigment cell" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003116 name: parenchymal cell namespace: Planarian_Anatomy def: "cell which is part of the parenchyma" [PMID:19247960, PMID:29674431] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003200 name: G1 phase neoblast namespace: Planarian_Anatomy def: "neoblast undergoing mitotic G1 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003201 name: S phase neoblast namespace: Planarian_Anatomy def: "neoblast undergoing mitotic S phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003202 name: G2 phase neoblast namespace: Planarian_Anatomy def: "neoblast undergoing mitotic G2 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003203 name: prophase neoblast namespace: Planarian_Anatomy def: "neoblast undergoing mitotic prophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by http://purl.obolibrary.org/obo/plana/images/mitoticprophase.png {comment="Image is an electron micrograph showing a neoblast undergoing mitotic prophase (outlined). Note the difference in appearance compared to neighboring cells, nuclei labeled \"N.\" Scale bar is 2 um."} [Term] id: PLANA:0003204 name: metaphase neoblast namespace: Planarian_Anatomy def: "neoblast undergoing mitotic metaphase" [] synonym: "M phase neoblast" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by http://purl.obolibrary.org/obo/plana/images/metaphaseneoblast.png {comment="Image is an electron micrograph depicting cells in the mesenchyme, near the regeneration blastema. In the middle of the image, outlined, a cell is undergoing mitotic metaphase. This cell's chromosomes can be seen in a vertical arrangement. Scale bar is 2um."} [Term] id: PLANA:0003205 name: anaphase neoblast namespace: Planarian_Anatomy def: "neoblast undergoing mitotic anaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by http://purl.obolibrary.org/obo/plana/images/anaphaseneoblast.png {comment="Image is an electron micrograph showing a neoblast undergoing mitotic anaphase. The entire cell has been outlined and the condensed chromatin is visible inside. Scale bar is 2um."} [Term] id: PLANA:0003206 name: telophase neoblast namespace: Planarian_Anatomy def: "neoblast undergoing mitotic telophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by http://purl.obolibrary.org/obo/plana/images/mitotictelophase.png {comment="Image is an electron micrograph showing a neoblast undergoing mitotic telophase (outlined). The condensed chromatin is visible inside and has been partially outlined by the nuclear envelope. Scale bar is 1um."} [Term] id: PLANA:0003207 name: G1 phase spermatogonial stem cell namespace: Planarian_Anatomy def: "spermatogonial stem cell undergoing mitotic G1 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003208 name: S phase spermatogonial stem cell namespace: Planarian_Anatomy def: "spermatogonial stem cell undergoing mitotic S phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003209 name: G2 phase spermatogonial stem cell namespace: Planarian_Anatomy def: "spermatogonial stem cell undergoing mitotic G2 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003210 name: prophase spermatogonial stem cell namespace: Planarian_Anatomy def: "spermatogonial stem cell undergoing mitotic prophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003211 name: metaphase spermatogonial stem cell namespace: Planarian_Anatomy def: "spermatogonial stem cell undergoing mitotic metaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003212 name: anaphase spermatogonial stem cell namespace: Planarian_Anatomy def: "spermatogonial stem cell undergoing mitotic anaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003213 name: telophase spermatogonial stem cell namespace: Planarian_Anatomy def: "spermatogonial stem cell undergoing mitotic telophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003214 name: G1 phase oogonial stem cell namespace: Planarian_Anatomy def: "oogonial stem cell undergoing mitotic G1 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003215 name: S phase oogonial stem cell namespace: Planarian_Anatomy def: "oogonial stem cell undergoing mitotic S phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003216 name: G2 phase oogonial stem cell namespace: Planarian_Anatomy def: "oogonial stem cell undergoing mitotic G2 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003217 name: prophase oogonial stem cell namespace: Planarian_Anatomy def: "oogonial stem cell undergoing mitotic prophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003218 name: metaphase oogonial stem cell namespace: Planarian_Anatomy def: "oogonial stem cell undergoing mitotic metaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003219 name: anaphase oogonial stem cell namespace: Planarian_Anatomy def: "oogonial stem cell undergoing mitotic anaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003220 name: telophase oogonial stem cell namespace: Planarian_Anatomy def: "oogonial stem cell undergoing mitotic telophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003221 name: G1 phase spermatogonium namespace: Planarian_Anatomy def: "spermatogonium undergoing mitotic G1 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003222 name: S phase spermatogonium namespace: Planarian_Anatomy def: "spermatogonium undergoing mitotic S phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003223 name: G2 phase spermatogonium namespace: Planarian_Anatomy def: "spermatogonium undergoing mitotic G2 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003224 name: prophase spermatogonium namespace: Planarian_Anatomy def: "spermatogonium undergoing mitotic prophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003225 name: metaphase spermatogonia namespace: Planarian_Anatomy def: "spermatogonium undergoing mitotic metaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003226 name: anaphase spermatogonia namespace: Planarian_Anatomy def: "spermatogonium undergoing mitotic anaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003227 name: telophase spermatogonium namespace: Planarian_Anatomy def: "spermatogonium undergoing mitotic telophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003228 name: G1 phase oogonial cell namespace: Planarian_Anatomy def: "oogonial cell undergoing mitotic G1 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003229 name: S phase oogonial cell namespace: Planarian_Anatomy def: "oogonial cell undergoing mitotic S phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003230 name: G2 phase oogonial cell namespace: Planarian_Anatomy def: "oogonial cell undergoing mitotic G2 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003231 name: prophase oogonial cell namespace: Planarian_Anatomy def: "oogonial cell undergoing mitotic prophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003232 name: metaphase oogonial cell namespace: Planarian_Anatomy def: "oogonial cell undergoing mitotic metaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003233 name: anaphase oogonial cell namespace: Planarian_Anatomy def: "oogonial cell undergoing mitotic anaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003234 name: telophase oogonial cell namespace: Planarian_Anatomy def: "oogonial cell undergoing mitotic telophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003235 name: G1 phase germ cell cyst namespace: Planarian_Anatomy def: "germ cell cyst undergoing mitotic G1 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003236 name: S phase germ cell cyst namespace: Planarian_Anatomy def: "germ cell cyst undergoing mitotic S phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003237 name: G2 phase germ cell cyst namespace: Planarian_Anatomy def: "germ cell cyst undergoing mitotic G2 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003238 name: prophase germ cell cyst namespace: Planarian_Anatomy def: "germ cell cyst undergoing mitotic prophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003239 name: metaphase germ cell cyst namespace: Planarian_Anatomy def: "germ cell cyst undergoing mitotic metaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003240 name: anaphase germ cell cyst namespace: Planarian_Anatomy def: "germ cell cyst undergoing mitotic anaphase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003241 name: telophase germ cell cyst namespace: Planarian_Anatomy def: "germ cell cyst undergoing mitotic telophase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003242 name: meiotic S phase spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic S phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003243 name: meiotic G1 phase spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic G1 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003244 name: meiotic G2 phase spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic G2 phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003245 name: meiotic prophase I spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic prophase I" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003246 name: leptotene stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing leptotene" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003247 name: zygotene stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing zygotene" [https://doi.org/10.1101/279364] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003248 name: pachytene stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing pachytene" [https://doi.org/10.1101/279364] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003249 name: diplotene stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing diplotene" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003250 name: diakinesis stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing diakinesis" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003251 name: meiotic metaphase 1 stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic metaphase I" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003252 name: meiotic anaphase I stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic anaphase I" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003253 name: meiotic telophase I spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic telophase I" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003254 name: meiosis II stage spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiosis II cell cycle phase" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003255 name: meiotic prophase II spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic prophase II" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003256 name: meiotic metaphase 2 spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic metaphase II" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003257 name: meiotic anaphase II spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic anaphase II" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003258 name: meiotic telophase II spermatocyte namespace: Planarian_Anatomy def: "spermatocyte undergoing meiotic telophase II" [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003300 name: cephalic ganglia primordium namespace: Planarian_Anatomy def: "This primordium develops into cephalic ganglia" [] synonym: "brain primordia" EXACT [] synonym: "brain primordium" EXACT [] synonym: "brain primoridia" EXACT [] synonym: "brain rudiment" EXACT [] synonym: "cephalic ganglia primordia" EXACT [] synonym: "cephalic ganglia primordium" EXACT [] xref: PMID:16033796 xref: PMID:17553481 xref: PMID:17905225 xref: PMID:19174194 xref: PMID:21806978 xref: PMID:22339734 xref: PMID:23318635 xref: PMID:25772472 xref: PMID:26525673 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003301 name: eye primordium namespace: Planarian_Anatomy def: "This primordium develops into eye" [] synonym: "eye aggregate" EXACT [] xref: PMID:22884275 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003302 name: pharynx primordium namespace: Planarian_Anatomy def: "This primordium develops into pharynx" [] xref: PMID:18202849 xref: PMID:21282632 xref: PMID:25254346 xref: PMID:26556349 xref: PMID:27074666 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003303 name: pigment cup primordium namespace: Planarian_Anatomy def: "This primordium develops into optic cup" [] synonym: "optic cup primordium" EXACT [] xref: PMID:21852957 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003304 name: testis primordium namespace: Planarian_Anatomy def: "This primordium develops into testis" [] xref: PMID:23652002 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003305 name: gonad primoridium namespace: Planarian_Anatomy def: "This primordium develops into gonad" [] is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003400 name: protonephridial lumen namespace: Planarian_Anatomy def: "lumen which is part of the protonephridia" [] xref: PMID:26057828 is_a: BFO:0000004 ! independent continuant property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003401 name: testis lumen namespace: Planarian_Anatomy def: "lumen which is part of the testis" [] xref: PMID:17390146 is_a: BFO:0000004 ! independent continuant property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003402 name: ovary lumen namespace: Planarian_Anatomy def: "lumen which is part of the ovary" [] xref: PMID:19247960 is_a: BFO:0000004 ! independent continuant property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003403 name: flame cell lumen namespace: Planarian_Anatomy def: "lumen which is part of the flame cell" [] synonym: "flame cell barrel lumen" EXACT [] xref: PMID:21828097 is_a: BFO:0000004 ! independent continuant property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003500 name: cephalic ganglia progenitor cell namespace: Planarian_Anatomy def: "A progenitor cell that gives rise to one or more of the cell type(s) in the nervous system." [] synonym: "brain progenitor" EXACT [] synonym: "brain progentitor cell" EXACT [] xref: PMID:26525673 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003501 name: dorsal epidermis progenitor cell namespace: Planarian_Anatomy def: "A progenitor cell that gives rise to one or more of the cell type(s) in the dorsal epidermis." [] xref: PMID:28292427 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003502 name: optic cup progenitor cell namespace: Planarian_Anatomy def: "A progenitor cell that gives rise to optic cup cells of the eye." [] synonym: "optic cup trail cell" EXACT [] xref: PMID:21852957 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003503 name: ventral epidermis progenitor cell namespace: Planarian_Anatomy def: "A progenitor cell that gives rise to one or more of the cell type(s) in the epidermis." [] xref: PMID:28292427 is_a: CARO:0000000 ! anatomical entity property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003600 name: head fragment namespace: Planarian_Anatomy def: "A fragment derived from a prepharyngeal amputation encompassing the head." [] synonym: "head piece" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003601 name: trunk fragment namespace: Planarian_Anatomy def: "A fragment derived from pre- and post-pharyngeal amputations, encompassing the pharynx and parapharyngeal region." [] synonym: "trunk piece" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003602 name: tail fragment namespace: Planarian_Anatomy def: "A fragment derived from a postpharyngeal amputation encompassing the tail." [] synonym: "tail piece" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003603 name: prepharyngeal fragment namespace: Planarian_Anatomy def: "A fragment derived from two prepharyngeal amputations, removing the head and posterior regions of the animal." [] synonym: "neck fragment" EXACT [] synonym: "neck piece" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003604 name: postpharyngeal fragment namespace: Planarian_Anatomy def: "A fragment derived from two postpharyngeal amputations, removing the anterior region and the tail tip." [] synonym: "post-pharyngeal fragment" EXACT [] synonym: "post-pharyngeal piece" EXACT [] synonym: "postpharyngeal piece" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003605 name: anterior fragment namespace: Planarian_Anatomy def: "A fragment encompassing all or part of the anterior region of the animal." [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003606 name: posterior fragment namespace: Planarian_Anatomy def: "A fragment encompassing all or part of the posterior region of the animal." [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003607 name: lateral fragment namespace: Planarian_Anatomy def: "A fragment derived from an amputation parallel to or along any edge, which overlaps the lateral region, dorso-lateral region, ventro-lateral region, antero-lateral margin, lateral margin, ventro-lateral margin, postero-lateral margin, dorso-lateral margin, antero-lateral region, postero-lateral region. [SMR: a fragment that encompasses the side of the animal, not necessarily longituduinal, or parallel to the midline]" [] synonym: "edge fragment" EXACT [] synonym: "longitudinal fragment" EXACT [] synonym: "sagittal fragment" EXACT [] synonym: "side fragment" EXACT [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003608 name: longitudinal fragment namespace: Planarian_Anatomy def: "a fragment derived from an amputation parallel to the midline." [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003609 name: plug fragment namespace: Planarian_Anatomy def: "A 3D piece of tissue, usually though the whole depth of the animal encompassing both dorsal and ventral sides, often made with a biopsy punch." [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003610 name: wedge fragment namespace: Planarian_Anatomy def: "A piece of tissue removed from the lateral margin at any given point that extendes interiorly to more medial structures." [] property_value: http://purl.obolibrary.org/obo/foaf_depicted_by urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003700 name: dorsal region of head fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment derived from a prepharyngeal amputation encompassing the head." [] synonym: "dorsal region of the whole animal of head fragment" EXACT [] is_a: PLANA:0003701 ! ventral region of head fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003600 ! head fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003701 name: ventral region of head fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment derived from a prepharyngeal amputation encompassing the head." [] synonym: "ventral region of the whole animal of head fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003600 ! head fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003600 ! head fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003702 name: anterior region of head fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment derived from a prepharyngeal amputation encompassing the head." [] synonym: "anterior region of head fragment" EXACT [] is_a: PLANA:0003703 ! posterior region of head fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003600 ! head fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003703 name: posterior region of head fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment derived from a prepharyngeal amputation encompassing the head." [] synonym: "posterior region of head fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003600 ! head fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003600 ! head fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003704 name: dorsal region of trunk fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment derived from pre- and post-pharyngeal amputations, encompassing the pharynx and parapharyngeal region." [] synonym: "dorsal region of the whole animal of trunk fragment" EXACT [] is_a: PLANA:0003705 ! ventral region of trunk fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003601 ! trunk fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003705 name: ventral region of trunk fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment derived from pre- and post-pharyngeal amputations, encompassing the pharynx and parapharyngeal region." [] synonym: "ventral region of the whole animal of trunk fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003601 ! trunk fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003601 ! trunk fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003706 name: anterior region of trunk fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment derived from pre- and post-pharyngeal amputations, encompassing the pharynx and parapharyngeal region." [] synonym: "anterior region of trunk fragment" EXACT [] is_a: PLANA:0003707 ! posterior region of trunk fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003601 ! trunk fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003707 name: posterior region of trunk fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment derived from pre- and post-pharyngeal amputations, encompassing the pharynx and parapharyngeal region." [] synonym: "posterior region of trunk fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003601 ! trunk fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003601 ! trunk fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003708 name: dorsal region of tail fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment derived from a postpharyngeal amputation encompassing the tail." [] synonym: "dorsal region of the whole animal of tail fragment" EXACT [] is_a: PLANA:0003709 ! ventral region of tail fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003602 ! tail fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003709 name: ventral region of tail fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment derived from a postpharyngeal amputation encompassing the tail." [] synonym: "ventral region of the whole animal of tail fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003602 ! tail fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003602 ! tail fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003710 name: anterior region of tail fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment derived from a postpharyngeal amputation encompassing the tail." [] synonym: "anterior region of tail fragment" EXACT [] is_a: PLANA:0003711 ! posterior region of tail fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003602 ! tail fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003711 name: posterior region of tail fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment derived from a postpharyngeal amputation encompassing the tail." [] synonym: "posterior region of tail fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003602 ! tail fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003602 ! tail fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003712 name: dorsal region of prepharyngeal fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment derived from two prepharyngeal amputations, removing the head and posterior regions of the animal." [] synonym: "dorsal region of the whole animal of prepharyngeal fragment" EXACT [] is_a: PLANA:0003713 ! ventral region of prepharyngeal fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003603 ! prepharyngeal fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003713 name: ventral region of prepharyngeal fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment derived from two prepharyngeal amputations, removing the head and posterior regions of the animal." [] synonym: "ventral region of the whole animal of prepharyngeal fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003603 ! prepharyngeal fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003603 ! prepharyngeal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003714 name: anterior region of prepharyngeal fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment derived from two prepharyngeal amputations, removing the head and posterior regions of the animal." [] synonym: "anterior region of prepharyngeal fragment" EXACT [] is_a: PLANA:0003715 ! posterior region of prepharyngeal fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003603 ! prepharyngeal fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003715 name: posterior region of prepharyngeal fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment derived from two prepharyngeal amputations, removing the head and posterior regions of the animal." [] synonym: "posterior region of prepharyngeal fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003603 ! prepharyngeal fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003603 ! prepharyngeal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003716 name: dorsal region of postpharyngeal fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment derived from two postpharyngeal amputations, removing the anterior region and the tail tip." [] synonym: "dorsal region of the whole animal of postpharyngeal fragment" EXACT [] is_a: PLANA:0003717 ! ventral region of postpharyngeal fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003604 ! postpharyngeal fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003717 name: ventral region of postpharyngeal fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment derived from two postpharyngeal amputations, removing the anterior region and the tail tip." [] synonym: "ventral region of the whole animal of postpharyngeal fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003604 ! postpharyngeal fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003604 ! postpharyngeal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003718 name: anterior region of postpharyngeal fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment derived from two postpharyngeal amputations, removing the anterior region and the tail tip." [] synonym: "anterior region of postpharyngeal fragment" EXACT [] is_a: PLANA:0003719 ! posterior region of postpharyngeal fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003604 ! postpharyngeal fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003719 name: posterior region of postpharyngeal fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment derived from two postpharyngeal amputations, removing the anterior region and the tail tip." [] synonym: "posterior region of postpharyngeal fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003604 ! postpharyngeal fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003604 ! postpharyngeal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003720 name: dorsal region of anterior fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment encompassing all or part of the anterior region of the animal." [] synonym: "dorsal region of the whole animal of anterior fragment" EXACT [] is_a: PLANA:0003721 ! ventral region of anterior fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003605 ! anterior fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003721 name: ventral region of anterior fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment encompassing all or part of the anterior region of the animal." [] synonym: "ventral region of the whole animal of anterior fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003605 ! anterior fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003605 ! anterior fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003722 name: anterior region of anterior fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment encompassing all or part of the anterior region of the animal." [] synonym: "anterior region of anterior fragment" EXACT [] is_a: PLANA:0003723 ! posterior region of anterior fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003605 ! anterior fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003723 name: posterior region of anterior fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment encompassing all or part of the anterior region of the animal." [] synonym: "posterior region of anterior fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003605 ! anterior fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003605 ! anterior fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003724 name: dorsal region of posterior fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment encompassing all or part of the posterior region of the animal." [] synonym: "dorsal region of the whole animal of posterior fragment" EXACT [] is_a: PLANA:0003725 ! ventral region of posterior fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003606 ! posterior fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003725 name: ventral region of posterior fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment encompassing all or part of the posterior region of the animal." [] synonym: "ventral region of the whole animal of posterior fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003606 ! posterior fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003606 ! posterior fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003726 name: anterior region of posterior fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment encompassing all or part of the posterior region of the animal." [] synonym: "anterior region of posterior fragment" EXACT [] is_a: PLANA:0003727 ! posterior region of posterior fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003606 ! posterior fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003727 name: posterior region of posterior fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment encompassing all or part of the posterior region of the animal." [] synonym: "posterior region of posterior fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003606 ! posterior fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003606 ! posterior fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003728 name: dorsal region of lateral fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment derived from an amputation parallel to or along any edge, which overlaps the lateral region, dorso-lateral region, ventro-lateral region, antero-lateral margin, lateral margin, ventro-lateral margin, postero-lateral margin, dorso-lateral margin, antero-lateral region, postero-lateral region." [] synonym: "dorsal region of the whole animal of lateral fragment" EXACT [] is_a: PLANA:0003729 ! ventral region of lateral fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003607 ! lateral fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003729 name: ventral region of lateral fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment derived from an amputation parallel to or along any edge, which overlaps the lateral region, dorso-lateral region, ventro-lateral region, antero-lateral margin, lateral margin, ventro-lateral margin, postero-lateral margin, dorso-lateral margin, antero-lateral region, postero-lateral region." [] synonym: "ventral region of the whole animal of lateral fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003607 ! lateral fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003607 ! lateral fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003730 name: anterior region of lateral fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment derived from an amputation parallel to or along any edge, which overlaps the lateral region, dorso-lateral region, ventro-lateral region, antero-lateral margin, lateral margin, ventro-lateral margin, postero-lateral margin, dorso-lateral margin, antero-lateral region, postero-lateral region." [] synonym: "anterior region of lateral fragment" EXACT [] is_a: PLANA:0003731 ! posterior region of lateral fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003607 ! lateral fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003731 name: posterior region of lateral fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment derived from an amputation parallel to or along any edge, which overlaps the lateral region, dorso-lateral region, ventro-lateral region, antero-lateral margin, lateral margin, ventro-lateral margin, postero-lateral margin, dorso-lateral margin, antero-lateral region, postero-lateral region." [] synonym: "posterior region of lateral fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003607 ! lateral fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003607 ! lateral fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003732 name: dorsal region of longitudinal fragment namespace: Planarian_Anatomy def: "The dorsal region of a fragment derived from an amputation parallel to the midline." [] synonym: "dorsal region of the whole animal of longitudinal fragment" EXACT [] is_a: PLANA:0003733 ! ventral region of longitudinal fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003608 ! longitudinal fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003733 name: ventral region of longitudinal fragment namespace: Planarian_Anatomy def: "The ventral region of a fragment derived from an amputation parallel to the midline." [] synonym: "ventral region of the whole animal of longitudinal fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003608 ! longitudinal fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003608 ! longitudinal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003734 name: anterior region of longitudinal fragment namespace: Planarian_Anatomy def: "The anterior region of a fragment derived from an amputation parallel to the midline." [] synonym: "anterior region of longitudinal fragment" EXACT [] is_a: PLANA:0003735 ! posterior region of longitudinal fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003608 ! longitudinal fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003735 name: posterior region of longitudinal fragment namespace: Planarian_Anatomy def: "The posterior region of a fragment derived from an amputation parallel to the midline." [] synonym: "posterior region of longitudinal fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003608 ! longitudinal fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003608 ! longitudinal fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003736 name: dorsal region of plug fragment namespace: Planarian_Anatomy def: "The dorsal region of a 3D piece of tissue, usually though the whole depth of the animal encompassing both dorsal and ventral sides, often made with a biopsy punch." [] synonym: "dorsal region of the whole animal of plug fragment" EXACT [] is_a: PLANA:0003737 ! ventral region of plug fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003609 ! plug fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003737 name: ventral region of plug fragment namespace: Planarian_Anatomy def: "The ventral region of a 3D piece of tissue, usually though the whole depth of the animal encompassing both dorsal and ventral sides, often made with a biopsy punch." [] synonym: "ventral region of the whole animal of plug fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003609 ! plug fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003609 ! plug fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003738 name: anterior region of plug fragment namespace: Planarian_Anatomy def: "The anterior region of a 3D piece of tissue, usually though the whole depth of the animal encompassing both dorsal and ventral sides, often made with a biopsy punch." [] synonym: "anterior region of plug fragment" EXACT [] is_a: PLANA:0003739 ! posterior region of plug fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003609 ! plug fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003739 name: posterior region of plug fragment namespace: Planarian_Anatomy def: "The posterior region of a 3D piece of tissue, usually though the whole depth of the animal encompassing both dorsal and ventral sides, often made with a biopsy punch." [] synonym: "posterior region of plug fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003609 ! plug fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003609 ! plug fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003740 name: dorsal region of plug fragment namespace: Planarian_Anatomy def: "The dorsal region of a piece of tissue removed from the lateral margin at any given point that extendes interiorly to more medial structures." [] synonym: "dorsal region of the whole animal of wedge fragment" EXACT [] is_a: PLANA:0003741 ! ventral region of plug fragment intersection_of: has_component PLANA:0000141 ! dorsal region of the whole animal intersection_of: part_of PLANA:0003610 ! wedge fragment relationship: has_component PLANA:0000141 ! dorsal region of the whole animal property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003741 name: ventral region of plug fragment namespace: Planarian_Anatomy def: "The ventral region of a piece of tissue removed from the lateral margin at any given point that extendes interiorly to more medial structures." [] synonym: "ventral region of the whole animal of wedge fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component PLANA:0000143 ! ventral region of the whole animal intersection_of: part_of PLANA:0003610 ! wedge fragment relationship: has_component PLANA:0000143 ! ventral region of the whole animal relationship: part_of PLANA:0003610 ! wedge fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003742 name: anterior region of wedge fragment namespace: Planarian_Anatomy def: "The anterior region of a piece of tissue removed from the lateral margin at any given point that extendes interiorly to more medial structures." [] synonym: "anterior region of wedge fragment" EXACT [] is_a: PLANA:0003743 ! posterior region of wedge fragment intersection_of: has_component BSPO:0000071 ! anterior region intersection_of: part_of PLANA:0003610 ! wedge fragment relationship: has_component BSPO:0000071 ! anterior region property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0003743 name: posterior region of wedge fragment namespace: Planarian_Anatomy def: "The posterior region of a piece of tissue removed from the lateral margin at any given point that extendes interiorly to more medial structures." [] synonym: "posterior region of wedge fragment" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000072 ! posterior region intersection_of: part_of PLANA:0003610 ! wedge fragment relationship: has_component BSPO:0000072 ! posterior region relationship: part_of PLANA:0003610 ! wedge fragment property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0004503 name: adult hermaphrodite namespace: Planarian_Anatomy def: "A fully formed, sexually mature organism that reproduces through cross-fertilization." [] synonym: "sexual adult" EXACT [] synonym: "sexually mature adult" EXACT [] xref: PMID:11972158 xref: PMID:19022767 is_a: UBERON:0000105 ! life cycle stage relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/sexuallymatureadult.png {comment="Depcited by field shows a light microscopy image of a sexually mature adult with a scale bar of 2 mm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4414 [Term] id: PLANA:0004504 name: asexual adult namespace: Planarian_Anatomy def: "Asexually reproducing Schmidtea mediterranea exist as constitutive adults, undergoing successive cycles of fission and whole animal regeneration. Asexual Schmidtea mediterranea contain primordial germ cells, but do not possess a reproductive system." [] xref: PMID:11972158 xref: PMID:17376870 is_a: UBERON:0000105 ! life cycle stage relationship: specific_to PLANA:0000024 ! Smed asexual biotype property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/asexualadult.png {comment="Depicted by field shows an asexual adult with a scale bar of 500um"} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4441 [Term] id: PLANA:0004506 name: testis somatic gonadal cell namespace: Planarian_Anatomy def: "dmd-1+ expressing somatic cells within the testis that promote male GSC maintenance. dmd-1+, ophis-1+ somatic gonadal cells ensheath germ cells via long cytoplasmic processes and promote differentiation." [] synonym: "somatic gonadal cell of the testis" EXACT [] synonym: "somatic niche cell of the testis" EXACT [] synonym: "somatic testis cell" EXACT [] xref: PMID:23652002 xref: PMID:27163480 is_a: BFO:0000040 ! material entity is_a: PLANA:0002096 ! somatic gonadal cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000208 ! testis relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4933 [Term] id: PLANA:0004507 name: ovarian somatic gonadal cell namespace: Planarian_Anatomy def: "ophis+ somatic cells (gh4-, nanos-) in the ovary that may provide trophic support to female germline stem cells and differentiating oogonia." [] synonym: "somatic follicular cell of the ovary" EXACT [] synonym: "somatic ovarian cell" EXACT [] xref: PMID:27163480 is_a: BFO:0000040 ! material entity is_a: PLANA:0000119 ! terminally differentiated cell relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000204 ! ovary relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4744 [Term] id: PLANA:0004511 name: oral-aboral axis of the embryo namespace: Planarian_Anatomy def: "Axis that runs from the oral pole and to the aboral pole of the spherical embryo (Stage 3 through early Stage 6). The oral pole is centered around the embryonic pharynx; the aboral pole is located opposite the embryonic pharynx." [PMID:28072387] synonym: "oral-aboral axis of embryo" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000198 ! oral-aboral axis intersection_of: part_of PLANA:0000116 ! embryo relationship: has_component BSPO:0000198 ! oral-aboral axis relationship: part_of PLANA:0000116 ! embryo property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/oralaboralaxis.png {comment="Illustration noting the oral-aboral axis in cyan double headed arrow. It starts at the embryonic pharynx and extends to opposite pole."} [Term] id: PLANA:0004512 name: primitive ectoderm surface namespace: Planarian_Anatomy def: "The apical surface of the single layered primitive ectoderm that is in contact with the environment." [] xref: https://github.com/obophenotype/planaria-ontology/blob/master/metadata/planarefs/planaref-0000001.md xref: OCLC:20423827 xref: OCLC:464776945 xref: OCLC:82522822 xref: PMID:28072387 is_a: BSPO:0000005 ! anatomical surface relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000029 ! primitive ectoderm relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4824 [Term] id: PLANA:0004513 name: primtive gut cell surface namespace: Planarian_Anatomy def: "The surface of the primitive gut cells in contact with the embryonic wall." [] xref: PMID:28072387 is_a: BSPO:0000005 ! anatomical surface relationship: existence_ends_during_or_before PLANA:0000005 ! Stage 5 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: part_of PLANA:0000085 ! primitive gut cell relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4828 [Term] id: PLANA:0004514 name: embryonic gut cell surface namespace: Planarian_Anatomy def: "The surface of phagocytic embryonic gut cells in contact with ingested yolk cells." [] xref: PMID:28072387 is_a: BSPO:0000005 ! anatomical surface relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000004 ! Stage 4 relationship: part_of PLANA:0000059 ! embryonic gut cell relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4551 [Term] id: PLANA:0004516 name: embryonic pharynx lumen epithelial surface namespace: Planarian_Anatomy def: "The epithelial cell surface lining the embryonic pharynx lumen." [] xref: PMID:20100474 xref: PMID:28072387 is_a: BSPO:0000005 ! anatomical surface relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000023 ! embryonic pharynx relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4556 [Term] id: PLANA:0004517 name: blastomere namespace: Planarian_Anatomy def: "An undifferentiated, cycling embryonic cell in Stage 1-5 embryos that expresses piwi-1, numerous adult asexual neoblast enriched genes, and early embryo enriched genes. Blastomeres give rise to temporary embryonic tissues during Stage 2, continue dividing asynchronously in the embryonic wall, and ultimately give rise to neoblasts and adult lineage progenitors beginning in Stage 5." [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000123 ! embryonic cell relationship: develops_from PLANA:0000098 ! zygote relationship: existence_ends_during_or_before PLANA:0000005 ! Stage 5 relationship: existence_starts_during_or_after PLANA:0000001 ! Stage 1 relationship: part_of PLANA:0000056 ! ectolecithal embryo relationship: RO:0001018 PLANA:0000041 ! contained in aboral hemisphere relationship: RO:0001018 PLANA:0000060 ! contained in embryonic wall relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000001 ! existence overlaps Stage 1 relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4451 [Term] id: PLANA:0004518 name: extraembryonic cell namespace: Planarian_Anatomy def: "Post-mitotic, terminally differentiated cells which, give rise to temporary embryonic tissues." [] xref: PMID:28072387 is_a: PLANA:0000119 ! terminally differentiated cell relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4581 [Term] id: PLANA:0004519 name: embryonic pharynx neuron namespace: Planarian_Anatomy def: "A neuronal cell innervating the embryonic pharynx. Four neurons innervate the radial muscle fibers that ring the oral opening." [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000099 ! neuron is_a: PLANA:0004518 ! extraembryonic cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000023 ! embryonic pharynx relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4557 [Term] id: PLANA:0004520 name: embryonic pharynx radial muscle cell namespace: Planarian_Anatomy def: "Differentiated radial muscle cell present in the embryonic pharynx." [] synonym: "embryonic pharynx radial muscle fiber" EXACT [] xref: PMID:16932928 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000101 ! muscle cell is_a: PLANA:0004518 ! extraembryonic cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000023 ! embryonic pharynx relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4558 [Term] id: PLANA:0004521 name: embryonic pharynx epithelial cell namespace: Planarian_Anatomy def: "foxA1+ epithelial cell contained in the embryonic pharynx." [] xref: PMID:20100474 xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000100 ! epithelial cell is_a: PLANA:0004518 ! extraembryonic cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000023 ! embryonic pharynx relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4554 [Term] id: PLANA:0004524 name: embryonic pharynx circular muscle cell namespace: Planarian_Anatomy def: "Differentiated muscle cell present in a circular muscle fiber of the embryonic pharynx." [] synonym: "embryonic pharynx circular muscle fiber" EXACT [] xref: PMID:16932928 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000101 ! muscle cell is_a: PLANA:0004518 ! extraembryonic cell relationship: develops_from PLANA:0004517 ! blastomere relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000002 ! Stage 2 relationship: part_of PLANA:0000023 ! embryonic pharynx relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000002 ! existence overlaps Stage 2 relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4553 [Term] id: PLANA:0004527 name: copulatory region namespace: Planarian_Anatomy def: "Portion of the sexual biotype body plan immediately posterior to the parapharyngeal region, and immediately anterior to the tail. Encompasses the copulatory apparatus." [] xref: PMID:22074376 is_a: PLANA:0000102 ! anatomical region relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: posterior_to PLANA:0000420 ! parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/copulatoryregion.png {comment="Depicted by field contains diagram representation of body region."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4505 [Term] id: PLANA:0004528 name: pharynx epithelium namespace: Planarian_Anatomy def: "Epithelia associated with the pharynx organ." [] synonym: "pharnyx epidermis" EXACT [] synonym: "pharyngeal epidermis" EXACT [] synonym: "pharyngeal epithelium" EXACT [] is_a: BFO:0000040 ! material entity is_a: PLANA:0002118 ! epithelium relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxepithelium.png {comment="Image is an electron micrograph of a transverse section through the pharynx. Outlined, is the outer epithium, which is an \"insunk\" epithelium where the nuclei are set back medially away from the epithelium surface. Here, just the surface is outlined.. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4769 [Term] id: PLANA:0004529 name: integumental system namespace: Planarian_Anatomy def: "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." [] xref: UBERON:0002416 is_a: PLANA:0000114 ! anatomical system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4640 [Term] id: PLANA:0004530 name: oviduct lumen namespace: Planarian_Anatomy def: "Anatomical space enclosed by the oviduct epithelium." [] xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: PLANA:0002053 ! lumen relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000205 ! oviduct relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4751 [Term] id: PLANA:0004531 name: sperm duct lumen namespace: Planarian_Anatomy def: "Anatomical space enclosed by the sperm duct epithelium." [] xref: PMID:19022767 xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: PLANA:0002053 ! lumen relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: immediately_deep_to PLANA:0002141 ! sperm duct epithelial surface relationship: part_of PLANA:0000207 ! sperm duct relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4891 [Term] id: PLANA:0004532 name: oviduct epithelium namespace: Planarian_Anatomy def: "Ciliated epithelium lining the oviduct." [] xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: PLANA:0002023 ! ciliated epithelium relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000205 ! oviduct relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4750 [Term] id: PLANA:0004533 name: sperm duct epithelium namespace: Planarian_Anatomy def: "Ciliated epithelium lining the sperm duct." [] xref: PMID:19022767 xref: PMID:22074376 is_a: BFO:0000040 ! material entity is_a: PLANA:0002023 ! ciliated epithelium relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000207 ! sperm duct relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4890 [Term] id: PLANA:0004534 name: tuba lumen namespace: Planarian_Anatomy def: "Anatomical space enclosed by tuba. Oocyte(s) are fertilized in the tuba lumen by sperm that traveled up the oviduct." [] xref: PMID:19022767 xref: PMID:20844018 xref: PMID:22074376 xref: PMID:27149082 is_a: BFO:0000040 ! material entity is_a: PLANA:0002053 ! lumen relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000230 ! tuba relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4946 [Term] id: PLANA:0007502 name: obsolete coronal plane comment: let odk import from BSPO if needed is_obsolete: true [Term] id: PLANA:0007503 name: sagittal plane of the whole animal namespace: Planarian_Anatomy def: "Anatomical plane which divides the body into right and left parts. This plane passes through the midline at the midline but does not always the midline." [] synonym: "sagittal plane of whole organism" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000417 ! sagittal plane intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000417 ! sagittal plane relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0007504 name: obsolete dorsal compartment comment: replaced by dorsal region PLANA:0000141 is_obsolete: true replaced_by: PLANA:0000141 [Term] id: PLANA:0007505 name: obsolete ventral compartment comment: now using patterned term ventral region PLANA:0000143 is_obsolete: true [Term] id: PLANA:0007506 name: obsolete anterior compartment comment: now using patterned term anterior region is_obsolete: true replaced_by: PLANA:0000140 [Term] id: PLANA:0007507 name: obsolete posterior compartment comment: replaced comment: replacing duplicate PLANA term is_obsolete: true replaced_by: PLANA:0000142 [Term] id: PLANA:0007508 name: obsolete extracellular component comment: choosing to use UBERON:0000476, acellular anatomical structure instead is_obsolete: true replaced_by: UBERON:0000476 [Term] id: PLANA:0007509 name: plasma membrane namespace: Planarian_Anatomy def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [] synonym: "cell membrane" EXACT [] synonym: "cytoplasmic membrane" EXACT [] xref: GO:0005886 xref: PMID:20511647 xref: PMID:27523733 is_a: PLANA:0000520 ! membrane property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/plasmamembrane.png {comment="Image is an electron micrograph showing several cells. Arrowheads label the plasma membrane, the boundary between cells. Scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4801 [Term] id: PLANA:0007511 name: extracellular organelle namespace: Planarian_Anatomy def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [] xref: GO:0043230 is_a: PLANA:0000525 ! organelle property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4579 [Term] id: PLANA:0007512 name: mitochondrion namespace: Planarian_Anatomy def: "A spherical to rod shaped organelle that generates the majority of a cell's supply of ATP via cellular respiration. Mitochondria have their own genome and consist of outer and inner membranes, the latter folds inward to form cristae. This folding increases the surface area of the membrane and thus increases the space available to produce ATP. The inner and outer membranes are separated by an intermembrane space, and the inner membrane encloses the matrix." [] synonym: "mitochondria" EXACT [] xref: PMID:21828097 xref: PMID:22318224 xref: PMID:26516985 xref: PMID:29100657 is_a: PLANA:0000527 ! intracellular membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/mitochondrion.png {comment="Image is an electron micrograph depicting a couple different cells. A few mitochondria have been labeled with arrowheads. Note the variation in shape from spherical to rod-like. This is dependent on cutting orientation at fission/fusion state of the mitochondria. Scale bar is 1 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4996 [Term] id: PLANA:0007513 name: endoplasmic reticulum namespace: Planarian_Anatomy def: "Network of interconnected, flattened, and/or tubular membrane, known as cisternae. This membrane is contiguous with the outer nuclear membrane. The endoplasmic reticulum is involved in both protein and lipid synthesis." [] xref: PMID:30143032 is_a: PLANA:0000527 ! intracellular membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/endoplasmiceeticulum.png {comment="Image is an electron micrograph depicting endoplasmic reticulum (magenta) in multiple cells. Scale bar is 0.5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4562 [Term] id: PLANA:0007514 name: rough endoplasmic reticulum namespace: Planarian_Anatomy def: "Network of interconnected, flattened, and/or tubular membrane, known as cisternae. This membrane is contiguous with the outer nuclear membrane. The endoplasmic reticulum is involved in both protein and lipid synthesis." [] xref: PMID:30143032 is_a: PLANA:0007513 ! endoplasmic reticulum property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/roughendoplasmicreticulum.png {comment="Image is an electron micrograph depicting the rough endoplasmic reticulum (arrowheads) of a cell. Ribosomes can be seen associating with the ER membrane creating a rough ER, as well as free within the cytoplasm of the cell. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4997 [Term] id: PLANA:0007515 name: smooth endoplasmic reticulum namespace: Planarian_Anatomy def: "Endoplamic reticulum that does not contain ribosomes, which synthesizes lipids, phospholipids, and steroids." [] is_a: PLANA:0007513 ! endoplasmic reticulum property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/smoothendoplasmicreticulum.png {comment="Image is an electron micrograph depicting smooth ER (arrowheads) in a cell, next to the nucleus (N). Ribosomes can be seen within the cytoplasm, but not associating with the ER membrane. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4998 [Term] id: PLANA:0007516 name: nuclear pore namespace: Planarian_Anatomy def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [] xref: GO:0005643 is_a: PLANA:0000532 ! nuclear part is_a: PLANA:0002079 ! pore property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/nuclearpore.png {comment="Image is an electron micrograph depicting the nuclear envelope. The nucleus takes up the top left corner of the image and two nuclear pores have been labeled with arrowheads. Scale bar is 200 nm."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4999 [Term] id: PLANA:0007518 name: lysosome namespace: Planarian_Anatomy def: "The digestive component of the cell. They are homogenous, dense, membrane bound organelles filled with acid hydrolases which break down polymers." [] xref: ISBN:0-71677033-4 xref: PMID:4853064 is_a: PLANA:0000527 ! intracellular membrane-bounded organelle property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/lysosome.png {comment="Image is an electron micrograph depicting two lysosomes (arrowheads) within a cell. The nucleus sits in the bottom left corner. Lysosomes can sometimes be identified by the swirling material they are breaking down inside. Scale bar is 0.5um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4664 [Term] id: PLANA:0007519 name: anterior-posterior axis of the whole animal namespace: Planarian_Anatomy def: "Axis that runs along the long axis of the animal from anterior (head) to posterior (tail). It is perpendicular to the dorsoventral axis and as such, it splits dorsal and ventral regions of the animal to either side." [] synonym: "anterior-posterior axis" EXACT [] synonym: "anterior-posterior axis of whole organism" EXACT [] synonym: "body axis" EXACT [] synonym: "longitudinal axis" EXACT [] synonym: "main body axis" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000013 ! anterior-posterior axis intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000013 ! anterior-posterior axis relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/anteroposterioraxis.png {comment="Depiction shows an asexual adult with the term annotated in yellow. Scale bar =500um"} [Term] id: PLANA:0007520 name: dorsal-ventral axis of the whole animal namespace: Planarian_Anatomy def: "Axis that runs along the short axis of the animal, perpendicular to the anteroposterior axis, running from the dorsal (back) side of the animal to the ventral (belly) side of the animal. This axis splits anterior and posterior regions of the animal to either side." [] synonym: "D/V axis" EXACT [] synonym: "dorsal-ventral axis" EXACT [] synonym: "dorsal-ventral axis of whole organism" EXACT [] synonym: "DV axis" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000016 ! dorsal-ventral axis intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000016 ! dorsal-ventral axis relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} [Term] id: PLANA:0007521 name: left-right axis of the whole animal namespace: Planarian_Anatomy def: "Axis perpendicular to both the anteroposterior and dorsoventral axis that runs from the left side of the animal, through the medial region (center) and out to the right side." [] synonym: "dextro-sinister axis" EXACT [] synonym: "left-right axis" EXACT [] synonym: "left-right axis of whole organism" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000017 ! left-right axis intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000017 ! left-right axis relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/dextro-sinisteraxis.png {comment="Depiction shows an asexual adult with the term annotated in yellow. Scale bar =500um"} [Term] id: PLANA:0007522 name: medial-lateral axis of the whole animal namespace: Planarian_Anatomy def: "Axis that runs from the center of the body, starting at the anteroposterior axis and out to the lateral (left, right, dorsal or ventral) surface of the animal." [] synonym: "medial-lateral axis" EXACT [] synonym: "medial-lateral axis of whole organism" EXACT [] synonym: "mediolateral" EXACT [] synonym: "mediolateral axis" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0001001 ! medial-lateral axis intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0001001 ! medial-lateral axis relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/mediolateralaxis.png {comment="Depiction shows an asexual adult with the term annotated in yellow. Scale bar =500um"} [Term] id: PLANA:0007523 name: proximal-distal axis of the whole animal namespace: Planarian_Anatomy def: "Axis that starts at the distal part of an appendage, closest to the body, and runs to the proximal part of an appendage, farthest from the body." [] synonym: "proximal-distal axis" EXACT [] synonym: "proximal-distal axis of whole organism" EXACT [] is_a: BFO:0000004 ! independent continuant intersection_of: has_component BSPO:0000015 ! proximal-distal axis intersection_of: part_of PLANA:0000136 ! whole organism relationship: has_component BSPO:0000015 ! proximal-distal axis relationship: part_of PLANA:0000136 ! whole organism property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/proximodistalaxis.png {comment="Pharynx of an asexual adult exposed by tricaine treatment. The proximodistal axis is denoted with the double headed magenta arrow."} [Term] id: PLANA:0007524 name: anterior pole namespace: Planarian_Anatomy def: "Distinct anterior cluster of muscle cells located at the midline which express notum, follistatin, zic-1, and foxD." [] synonym: "anterior signaling center" EXACT [] xref: PMID:18063755 xref: PMID:21566195 xref: PMID:23297191 xref: PMID:23318641 xref: PMID:23903188 xref: PMID:23954785 xref: PMID:24040508 xref: PMID:24415944 xref: PMID:24523458 xref: PMID:24704339 xref: PMID:24992682 xref: PMID:25254346 xref: PMID:25725068 xref: PMID:26062938 xref: PMID:26525673 xref: PMID:27074666 xref: PMID:27800171 xref: PMID:28216315 xref: PMID:28292427 xref: PMID:28893948 xref: PMID:29547123 xref: PMID:29906446 xref: PMID:30485821 is_a: BFO:0000040 ! material entity is_a: PLANA:0000102 ! anatomical region relationship: RO:0001018 PLANA:0000030 ! contained in midline relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4432 [Term] id: PLANA:0007525 name: posterior pole namespace: Planarian_Anatomy def: "Distinct posterior cluster of muscle cells located at the midline which express wnt1." [] synonym: "posterior regeneration pole" EXACT [] synonym: "tail tip" EXACT [] xref: PMID:18063755 xref: PMID:19805089 xref: PMID:21566195 xref: PMID:23318641 xref: PMID:23903188 xref: PMID:24415944 xref: PMID:25725068 xref: PMID:26062938 xref: PMID:27074666 xref: PMID:30485821 is_a: PLANA:0000102 ! anatomical region relationship: RO:0002490 PLANA:0000007 ! existence overlaps Stage 7 relationship: RO:0002490 PLANA:0000008 ! existence overlaps Stage 8 relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4811 [Term] id: PLANA:0007528 name: glial cell namespace: Planarian_Anatomy def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, guide neuronal migration during development, and exchange metabolites with neurons." [] synonym: "glia" EXACT [] synonym: "glia cell" EXACT [] xref: CL:0000125 xref: PMID:27612382 xref: PMID:27612384 xref: PMID:28137894 xref: PMID:29674431 xref: PMID:29674432 xref: PMID:30471994 is_a: BFO:0000040 ! material entity is_a: PLANA:0000561 ! neuron associated cell (sensu Nematoda and Protostomia) relationship: part_of PLANA:0000470 ! neuropil relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/glialcell.png {comment="Image is an electron micrograph depicting a section of the ventral nerve cord. The arrowheads point at a likely glial cell. Note the difference in darkness of cytoplasm in the cell body of the glial cell compared to the surrounding axons. Scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4626 [Term] id: PLANA:0007529 name: ganglion namespace: Planarian_Anatomy def: "A biological tissue mass of nerve cell bodies." [] synonym: "ganglia" EXACT [] xref: UBERON:0000045 is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-5000 [Term] id: PLANA:0007534 name: pharynx inner epithelium namespace: Planarian_Anatomy def: "Heavily ciliated epidermal cells covering the inner surface of the pharynx shaft." [] synonym: "epithelial pharynx lining" EXACT [] synonym: "epithelium lining the lumen of the pharynx" EXACT [] synonym: "inner epithelium" EXACT [] synonym: "inner pharyngeal epidermis" EXACT [] synonym: "inner pharyngeal epithelium" EXACT [] synonym: "inner pharynx epidermis" EXACT [] synonym: "inner pharynx epithelium" EXACT [] xref: doi:10.1002/jmor.1051550208 xref: OCLC:16809160 xref: PMID:24120894 is_a: BFO:0000040 ! material entity is_a: PLANA:0002023 ! ciliated epithelium relationship: immediately_superficial_to PLANA:0000474 ! pharynx inner circular muscle cell relationship: part_of PLANA:0000016 ! pharynx relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxinnerepithelium.png {comment="Image is an electron micrograph of a transverse section through the pharynx. An epidermal cell, a part of the inner epithelial layer, has been marked with arrowheads. Immediately deep to the inner epithelial layer of the pharynx is musculature that has been colored. Magenta = circular; blue = longitudinal; yellow = radial. Scale bar is 5 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4772 [Term] id: PLANA:0007535 name: pharynx circular muscle cell namespace: Planarian_Anatomy def: "Pharynx muscle fibers running circumferentially about the pharynx." [] synonym: "pharyngeal circular muscle cell" EXACT [] synonym: "pharynx circular muscle cell" EXACT [] synonym: "pharynx circular muscle fiber" EXACT [] xref: ASIN:B000M4NK9M is_a: BFO:0000040 ! material entity is_a: PLANA:0000101 ! muscle cell relationship: part_of PLANA:0000478 ! pharynx musculature relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/pharynxcircularmusclecell.png {comment="Image is an electron micrograph of a transverse section through the pharynx. The pharynx lumen it to the left. The inner circular muscle (arrowheads) is immediately deep to the inner epithelial layer of the pharynx. Magenta = circular; green = longitudinal; red = radial. Scale bar is 2 um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4767 [Term] id: PLANA:0007537 name: obsolete brain comment: replacing duplicate PLANA term is_obsolete: true replaced_by: PLANA:0000044 [Term] id: PLANA:0007538 name: adhesion gland namespace: Planarian_Anatomy def: "Groupings of specialized epithelial cells located along the dorsal ventral margin. Adhesion glands are comprised of three cell types, the viscid and releasing gland cells which penetrate through an epithelial anchor cell and terminate at the epidermal surface." [] synonym: "marginal adhesive gland" EXACT [] xref: ISBN:9780070316607 xref: OCLC:16809160 xref: PMID:20865784 is_a: BFO:0000040 ! material entity is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000484 ! secretory system relationship: RO:0001018 PLANA:0000043 ! contained in dorsal ventral margin of the whole animal relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/adhesiongland.png {comment="Image is an electron micrograph showing the multicellular total adhesion gland structure (outlined) embedded in the epidermis. Note that the gland cells cross the basal lamina into the epithelium. Ventral is up and scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4411 [Term] id: PLANA:0007539 name: anchor cell namespace: Planarian_Anatomy def: "Specialized epithelial cell located along the dorsoventral margin that surrounds the viscid and releasing gland cells." [] xref: OCLC:16809160 xref: PMID:20865784 is_a: BFO:0000040 ! material entity is_a: PLANA:0000487 ! acidophilic gland cell relationship: part_of PLANA:0007538 ! adhesion gland relationship: RO:0001018 PLANA:0000043 ! contained in dorsal ventral margin of the whole animal relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/anchorcell.png {comment="Image is an electron micrograph showing the total multicellualr adhesion gland structure. The anchor cell has been outlined, though mucus-filled projections of gland cells can be seen densely packed inside. Nucleus is that of the anchor cell. Ventral is up and scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4426 [Term] id: PLANA:0007540 name: viscid gland cell namespace: Planarian_Anatomy def: "A specialized insunk epithelial cell that is part of the adhesion glands which is responsible for production and excretion of the viscid substance allowing adherence to a substrate." [] xref: OCLC:16809160 xref: PMID:20865784 is_a: BFO:0000040 ! material entity is_a: PLANA:0000487 ! acidophilic gland cell relationship: part_of PLANA:0007538 ! adhesion gland relationship: RO:0001018 PLANA:0000043 ! contained in dorsal ventral margin of the whole animal relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/viscidglandcell.png {comment="Image is an electron micrograph showing the whole adhesion gland structure, specifically outlining a single cell (viscid gland cell) associated with this multicelluar structure. Ventral is up and scale bar is 2um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4956 [Term] id: PLANA:0007541 name: releasing gland cell namespace: Planarian_Anatomy def: "Specialized insunk epithelial cell that is part of the adhesion gland which is responsible for production of releasing substance." [] xref: OCLC:16809160 xref: PMID:20865784 is_a: BFO:0000040 ! material entity is_a: PLANA:0000487 ! acidophilic gland cell relationship: part_of PLANA:0007538 ! adhesion gland relationship: RO:0001018 PLANA:0000043 ! contained in dorsal ventral margin of the whole animal relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction http://purl.obolibrary.org/obo/plana/images/releasingglandcell.png {comment="Image is an electron micrograph showing the whole adhesion gland structure. Arrowheads mark releasing gland cells which are associated with this multicelluar structure. The releasing gland cells have very small excretory particles compared to the neighboring viscid gland. Ventral is up and scale bar is 1um."} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4847 [Term] id: PLANA:0007543 name: TrpA+ central nervous system neuron namespace: Planarian_Anatomy def: "A subset of TrpA+ neurons, located medially in the cephalic ganglia, whose formation is dependent on function of runt-1 and ap2." [] synonym: "TrpA+ neuron" EXACT [] xref: PMID:25254346 is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: PLANA:0000562 ! central nervous system neuron relationship: develops_from PLANA:0007546 ! TrpA+ neural progenitor cell relationship: part_of PLANA:0000044 ! cephalic ganglia relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4942 [Term] id: PLANA:0007544 name: cintillo+ sensory neuron namespace: Planarian_Anatomy def: "A subset of sensory neurons located along the dorsal head margin." [] synonym: "cintillo+ neuron" EXACT [] xref: PMID:12557210 xref: PMID:25254346 xref: PMID:29674431 is_a: BFO:0000040 ! material entity is_a: PLANA:0000552 ! sensory neuron relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000418 ! contained in head relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4496 [Term] id: PLANA:0007545 name: obsolete epidermal compartment comment: no longer designating mediolateral regions using the contained_in object property is_obsolete: true [Term] id: PLANA:0007546 name: TrpA+ neural progenitor cell namespace: Planarian_Anatomy def: "piwi-1+, runt-1+, ap2+ progenitor neoblasts required for production of TrpA+ neurons." [] xref: PMID:25254346 is_a: PLANA:0000012 ! neural progenitor cell is_a: PLANA:0000429 ! neoblast relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4943 [Term] id: PLANA:0007547 name: anterior pole progenitor cell namespace: Planarian_Anatomy def: "piwi-1+, foxD+, prep+ progenitor neoblasts required for formation of the anterior pole." [] xref: PMID:24415944 is_a: PLANA:0000429 ! neoblast property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4434 [Term] id: PLANA:0007548 name: transverse commissure namespace: Planarian_Anatomy def: "Axon tracts from ganglia that cross the midline, connecting the two ventral nerve cords." [] xref: PMID:17999079 is_a: PLANA:0002025 ! commissure relationship: part_of PLANA:0000097 ! ventral nerve cord relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4941 [Term] id: PLANA:0007549 name: obsolete body wall musculature compartment comment: no longer designating mediolateral regions using the contained_in object property is_obsolete: true [Term] id: PLANA:0007550 name: serotonergic neural progenitor cell namespace: Planarian_Anatomy def: "piwi-1+, lhx1/5-1+, pitx+ progenitor neoblasts required for specification of tph+ serotonergic neurons." [] xref: PMID:23903188 xref: PMID:24131630 xref: PMID:25254346 is_a: PLANA:0000012 ! neural progenitor cell is_a: PLANA:0000429 ! neoblast relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4877 [Term] id: PLANA:0007551 name: klf+ sensory neuron progenitor cell namespace: Planarian_Anatomy def: "piwi-1+, klf+ progenitor neoblasts required for production of cintillo+ sensory neurons." [] xref: PMID:25254346 is_a: PLANA:0000012 ! neural progenitor cell is_a: PLANA:0000429 ! neoblast relationship: part_of PLANA:0000080 ! peripheral nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4650 [Term] id: PLANA:0007552 name: nu neoblast namespace: Planarian_Anatomy def: "A population of piwi-2+, ston-2+, elav-2+, ptprd-9+ and msi-1+ progenitors that give rise to one or more neuronal (pc-2+, synapsin+) lineages." [] synonym: "vNeoblast" EXACT [] xref: PMID:27150006 is_a: PLANA:0000012 ! neural progenitor cell is_a: PLANA:0000429 ! neoblast relationship: part_of PLANA:0000025 ! nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4721 [Term] id: PLANA:0007553 name: lateral nerve namespace: Planarian_Anatomy def: "A nerve extending laterally from the ventral nerve cord that innervates the submuscular plexus." [] xref: PMID:17999079 is_a: PLANA:0000113 ! tissue relationship: part_of PLANA:0000080 ! peripheral nervous system relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: RO:0002490 PLANA:0004504 ! existence overlaps asexual adult property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4653 [Term] id: PLANA:0007554 name: obsolete parenchymal compartment comment: no longer designating mediolateral regions using the contained_in object property is_obsolete: true [Term] id: PLANA:0007555 name: pax3/7+ neural progenitor cell namespace: Planarian_Anatomy def: "piwi-1+, pax3/7+ progenitor neoblasts implicated in the production of DBH+ ventral midline neurons." [] xref: PMID:25254346 is_a: PLANA:0000012 ! neural progenitor cell is_a: PLANA:0000429 ! neoblast relationship: part_of PLANA:0000103 ! central nervous system property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4760 [Term] id: PLANA:0007556 name: embryonic pharynx lumen namespace: Planarian_Anatomy def: "A lumen enclosed by the embryonic pharynx epithelial cells through which yolk cells are transported into the embryonic gut cavity." [] xref: PMID:28072387 is_a: BFO:0000040 ! material entity is_a: PLANA:0002053 ! lumen relationship: existence_ends_during_or_before PLANA:0000006 ! Stage 6 relationship: existence_starts_during_or_after PLANA:0000003 ! Stage 3 relationship: immediately_deep_to PLANA:0004516 ! embryonic pharynx lumen epithelial surface relationship: part_of PLANA:0000023 ! embryonic pharynx relationship: RO:0001018 PLANA:0000076 ! contained in oral hemisphere relationship: RO:0002490 PLANA:0000003 ! existence overlaps Stage 3 relationship: RO:0002490 PLANA:0000004 ! existence overlaps Stage 4 relationship: RO:0002490 PLANA:0000005 ! existence overlaps Stage 5 relationship: RO:0002490 PLANA:0000006 ! existence overlaps Stage 6 relationship: specific_to PLANA:0000116 ! embryo property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4555 [Term] id: PLANA:0007557 name: testis nerve plexus namespace: Planarian_Anatomy def: "Nerve plexus surrounding the testis." [] xref: PMID:17999079 xref: PMID:7833618 is_a: BFO:0000040 ! material entity is_a: PLANA:0000492 ! nerve plexus relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000126 ! reproductive system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000141 ! contained in dorsal region of the whole animal relationship: RO:0001018 PLANA:0000142 ! contained in posterior compartment of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0001018 PLANA:0000420 ! contained in parapharyngeal region relationship: RO:0001018 PLANA:0000421 ! contained in tail relationship: RO:0001018 PLANA:0004527 ! contained in copulatory region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4931 [Term] id: PLANA:0007558 name: fission plane namespace: Planarian_Anatomy def: "Transverse anatomical plane, located approximately 1-2 mm from the posterior extremity of an adult animal, at which fission occurs." [] xref: OCLC:16809160 xref: PMID:11972158 is_a: BSPO:0000400 ! anatomical plane property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4592 [Term] id: PLANA:0007559 name: ovary nerve plexus namespace: Planarian_Anatomy def: "Nerve plexus surrounding the ovary." [] xref: PMID:17999079 xref: PMID:7833618 is_a: BFO:0000040 ! material entity is_a: PLANA:0000492 ! nerve plexus relationship: existence_starts_during_or_after PLANA:0000214 ! juvenile relationship: part_of PLANA:0000126 ! reproductive system relationship: RO:0001018 PLANA:0000140 ! contained in anterior region of the whole animal relationship: RO:0001018 PLANA:0000143 ! contained in ventral region of the whole animal relationship: RO:0001018 PLANA:0000419 ! contained in prepharyngeal region relationship: RO:0002490 PLANA:0000214 ! existence overlaps juvenile relationship: RO:0002490 PLANA:0004503 ! existence overlaps adult hermaphrodite relationship: specific_to PLANA:0000027 ! Smed sexual biotype property_value: foaf:depiction urn:dosdp:depicted:by {comment=""} created_by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4747 [Term] id: PLANA:0007560 name: obsolete gastrovascular compartment comment: no longer designating mediolateral regions using the contained_in object property is_obsolete: true [Term] id: PLANP:00000000 name: Planarian Phenotype [Term] id: PLANP:0000001 name: abnormal cytoplasmic vesicle part def: "Abnormality of cytoplasmic vesicle part." [] synonym: "abnormality of cytoplasmic vesicle part" EXACT [] is_a: PLANP:0000146 ! abnormal cytoplasmic part [Term] id: PLANP:0000002 name: abnormal medial-lateral axis def: "Abnormality of medial-lateral axis of the whole animal." [] synonym: "abnormality of medial-lateral axis of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000003 name: abnormal oviduct lumen def: "Abnormality of oviduct lumen." [] synonym: "abnormality of oviduct lumen" EXACT [] is_a: PLANP:0000023 ! abnormal oviduct is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000004 name: abnormal Category 4 cell def: "Abnormality of Category 4 cell." [] synonym: "abnormality of Category 4 cell" EXACT [] is_a: PLANP:0000117 ! abnormal epidermal progenitor cell is_a: PLANP:0000135 ! abnormal dorsal epidermis is_a: PLANP:0000211 ! abnormal non ciliated epithelial cell is_a: PLANP:0000582 ! abnormal epidermal cell is_a: PLANP:0000613 ! abnormal non-ciliated epidermis [Term] id: PLANP:0000006 name: abnormal zygote def: "Abnormality of zygote." [] synonym: "abnormality of zygote" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000008 name: abnormal male primordial germ cell def: "Abnormality of male primordial germ cell." [] synonym: "abnormality of male primordial germ cell" EXACT [] is_a: PLANP:0000128 ! abnormal male germ cell is_a: PLANP:0000283 ! abnormal stem cell [Term] id: PLANP:0000009 name: abnormal yolk cell def: "Abnormality of yolk cell." [] synonym: "abnormality of yolk cell" EXACT [] is_a: PLANP:0000032 ! abnormal reproductive system product is_a: PLANP:0000165 ! abnormal embryonic wall is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000010 name: abnormal fission plane def: "Abnormality of fission plane." [] synonym: "abnormality of fission plane" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000011 name: abnormal central nervous system neuron def: "Abnormality of central nervous system neuron." [] synonym: "abnormality of central nervous system neuron" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000012 name: abnormal pharynx musculature def: "Abnormality of pharynx musculature." [] synonym: "abnormality of pharynx musculature" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000186 ! abnormal musculature system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000014 name: abnormal collecting duct def: "Abnormality of collecting duct." [] synonym: "abnormality of collecting duct" EXACT [] is_a: PLANP:0000021 ! abnormal renal system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000015 name: abnormal nucleolus def: "Abnormality of nucleolus." [] synonym: "abnormality of nucleolus" EXACT [] is_a: PLANP:0000170 ! abnormal nuclear part [Term] id: PLANP:0000016 name: abnormal outer longitudinal muscle cell def: "Abnormality of outer longitudinal muscle cell." [] synonym: "abnormality of outer longitudinal muscle cell" EXACT [] is_a: PLANP:0000129 ! abnormal longitudinal muscle cell [Term] id: PLANP:0000017 name: abnormal tail stripe def: "Abnormality of tail stripe." [] synonym: "abnormality of tail stripe" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000018 name: obsolete abnormal gastrovascular compartment comment: no longer designating mediolateral regions using the contained_in object property [Term] id: PLANP:0000019 name: abnormal Smed sexual biotype def: "Abnormality of Smed sexual biotype." [] synonym: "abnormality of Smed sexual biotype" EXACT [] is_a: PLANP:0000305 ! abnormal biotype [Term] id: PLANP:0000020 name: abnormal rough endoplasmic reticulum def: "Abnormality of rough endoplasmic reticulum." [] synonym: "abnormality of rough endoplasmic reticulum" EXACT [] is_a: PLANP:0000313 ! abnormal endoplasmic reticulum [Term] id: PLANP:0000021 name: abnormal renal system def: "Abnormality of renal system." [] synonym: "abnormality of renal system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000022 name: abnormal brain commissure def: "Abnormality of brain commissure." [] synonym: "abnormality of brain commissure" EXACT [] is_a: PLANP:0000149 ! abnormal cephalic ganglia is_a: PLANP:0000575 ! abnormal commissure [Term] id: PLANP:0000023 name: abnormal oviduct def: "Abnormality of oviduct." [] synonym: "abnormality of oviduct" EXACT [] is_a: PLANP:0000638 ! abnormal reproductive organ [Term] id: PLANP:0000027 name: abnormal primitive ectoderm surface def: "Abnormality of primitive ectoderm surface." [] synonym: "abnormality of primitive ectoderm surface" EXACT [] is_a: PLANP:0000435 ! abnormal primitive ectoderm [Term] id: PLANP:0000029 name: abnormal neoblast def: "Abnormality of neoblast." [] synonym: "abnormality of neoblast" EXACT [] is_a: PLANP:0000283 ! abnormal stem cell is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000032 name: abnormal reproductive system product def: "Abnormality of reproductive system product." [] synonym: "abnormality of reproductive system product" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000033 name: abnormal pharynx inner longitudinal muscle cell def: "Abnormality of pharynx inner longitudinal muscle cell." [] synonym: "abnormality of pharynx inner longitudinal muscle cell" EXACT [] is_a: PLANP:0000212 ! abnormal pharynx longitudinal muscle cell [Term] id: PLANP:0000036 name: abnormal tail def: "Abnormality of tail." [] synonym: "abnormality of tail" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000038 name: abnormal prepharyngeal region def: "Abnormality of prepharyngeal region." [] synonym: "abnormality of prepharyngeal region" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000039 name: abnormal extracellular organelle def: "Abnormality of extracellular organelle." [] synonym: "abnormality of extracellular organelle" EXACT [] is_a: PLANP:0000306 ! abnormal organelle [Term] id: PLANP:0000041 name: abnormal distal tubule epithelial cell def: "Abnormality of distal tubule epithelial cell." [] synonym: "abnormality of distal tubule epithelial cell" EXACT [] is_a: PLANP:0000211 ! abnormal non ciliated epithelial cell is_a: PLANP:0000314 ! abnormal distal tubule [Term] id: PLANP:0000042 name: abnormal proximal tubule def: "Abnormality of proximal tubule." [] synonym: "abnormality of proximal tubule" EXACT [] is_a: PLANP:0000079 ! abnormal protonephridia is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000043 name: abnormal organ def: "Abnormality of organ." [] synonym: "abnormality of organ" EXACT [] is_a: PLANP:0000410 ! abnormal multicellular anatomical structure [Term] id: PLANP:0000044 name: abnormal pigment cup cell def: "Abnormality of pigment cup cell." [] synonym: "abnormality of pigment cup cell" EXACT [] is_a: PLANP:0000302 ! abnormal neuron associated cell (sensu Nematoda and Protostomia) is_a: PLANP:0000375 ! abnormal optic cup [Term] id: PLANP:0000045 name: abnormal glial cell def: "Abnormality of glial cell." [] synonym: "abnormality of glial cell" EXACT [] is_a: PLANP:0000302 ! abnormal neuron associated cell (sensu Nematoda and Protostomia) is_a: PLANP:0000355 ! abnormal neuropil [Term] id: PLANP:0000046 name: abnormal eye def: "Abnormality of eye." [] synonym: "abnormality of eye" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000198 ! abnormal visual system [Term] id: PLANP:0000047 name: abnormal goblet cell def: "Abnormality of goblet cell." [] synonym: "abnormality of goblet cell" EXACT [] is_a: PLANP:0000209 ! abnormal gastrodermis is_a: PLANP:0000331 ! abnormal secretory cell [Term] id: PLANP:0000048 name: abnormal gastrodermis surface def: "Abnormality of gastrodermis surface." [] synonym: "abnormality of gastrodermis surface" EXACT [] is_a: PLANP:0000175 ! abnormal gut [Term] id: PLANP:0000049 name: obsolete abnormal plane of autonomy comment: let odk import from BSPO if needed [Term] id: PLANP:0000050 name: abnormal bipolar neuron def: "Abnormality of bipolar neuron." [] synonym: "abnormality of bipolar neuron" EXACT [] is_a: PLANP:0000156 ! abnormal submuscular nerve plexus is_a: PLANP:0000335 ! abnormal interneuron is_a: PLANP:0000336 ! abnormal subepidermal nerve plexus is_a: PLANP:0000415 ! abnormal transverse commissure [Term] id: PLANP:0000051 name: abnormal definitive pharynx def: "Abnormality of pharynx." [] synonym: "abnormality of pharynx" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000285 ! abnormal digestive system [Term] id: PLANP:0000052 name: abnormal ventral epidermis def: "Abnormality of ventral epidermis." [] synonym: "abnormality of ventral epidermis" EXACT [] is_a: PLANP:0000427 ! abnormal epidermis [Term] id: PLANP:0000053 name: abnormal cintillo+ sensory neuron def: "Abnormality of cintillo+ sensory neuron." [] synonym: "abnormality of cintillo+ sensory neuron" EXACT [] is_a: PLANP:0000416 ! abnormal sensory neuron [Term] id: PLANP:0000054 name: abnormal pharynx lumen def: "Abnormality of pharynx lumen." [] synonym: "abnormality of pharynx lumen" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000056 name: abnormal sigma neoblast def: "Abnormality of sigma neoblast." [] synonym: "abnormality of sigma neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000057 name: abnormal inner longitudinal muscle cell def: "Abnormality of inner longitudinal muscle cell." [] synonym: "abnormality of inner longitudinal muscle cell" EXACT [] is_a: PLANP:0000129 ! abnormal longitudinal muscle cell [Term] id: PLANP:0000058 name: abnormal pharynx epithelium def: "Abnormality of pharynx epithelium." [] synonym: "abnormality of pharynx epithelium" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000665 ! abnormal epithelium [Term] id: PLANP:0000059 name: abnormal extraembryonic cell def: "Abnormality of extraembryonic cell." [] synonym: "abnormality of extraembryonic cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000060 name: abnormal head def: "Abnormality of head." [] synonym: "abnormality of head" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000062 name: obsolete abnormal Schmidtea mediterranea developmental term comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000064 name: obsolete abnormal dispersed cleavage comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000065 name: abnormal copulatory apparatus def: "Abnormality of copulatory apparatus." [] synonym: "abnormality of copulatory apparatus" EXACT [] is_a: PLANP:0000353 ! abnormal reproductive system is_a: PLANP:0000639 ! abnormal reproductive structure [Term] id: PLANP:0000067 name: abnormal intracellular non-membrane-bounded organelle def: "Abnormality of intracellular non-membrane-bounded organelle." [] synonym: "abnormality of intracellular non-membrane-bounded organelle" EXACT [] is_a: PLANP:0000192 ! abnormal non-membrane-bounded organelle is_a: PLANP:0000373 ! abnormal intracellular organelle [Term] id: PLANP:0000069 name: abnormal Stage 1 def: "Abnormality of Stage 1." [] synonym: "abnormality of Stage 1" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000070 name: abnormal autonomic neuron def: "Abnormality of autonomic neuron." [] synonym: "abnormality of autonomic neuron" EXACT [] is_a: PLANP:0000088 ! abnormal peripheral nervous system neuron [Term] id: PLANP:0000071 name: abnormal basal surface of the epidermis def: "Abnormality of basal surface of the epidermis." [] synonym: "abnormality of basal surface of the epidermis" EXACT [] is_a: PLANP:0000427 ! abnormal epidermis [Term] id: PLANP:0000074 name: obsolete abnormal acidophilic cytoplasm comment: term is not needed. [Term] id: PLANP:0000076 name: abnormal embryonic gut cell def: "Abnormality of embryonic gut cell." [] synonym: "abnormality of embryonic gut cell" EXACT [] is_a: PLANP:0000059 ! abnormal extraembryonic cell is_a: PLANP:0000581 ! abnormal embryonic gut [Term] id: PLANP:0000078 name: abnormal rhabdite def: "Abnormality of rhabdite." [] synonym: "abnormality of rhabdite" EXACT [] is_a: PLANP:0000248 ! abnormal epithelial cell component [Term] id: PLANP:0000079 name: abnormal protonephridia def: "Abnormality of protonephridia." [] synonym: "abnormality of protonephridia" EXACT [] is_a: PLANP:0000021 ! abnormal renal system is_a: PLANP:0000043 ! abnormal organ [Term] id: PLANP:0000080 name: abnormal round spermatid def: "Abnormality of round spermatid." [] synonym: "abnormality of round spermatid" EXACT [] is_a: PLANP:0000221 ! abnormal spermatid [Term] id: PLANP:0000082 name: abnormal basal lamina of epithelium def: "Abnormality of basal lamina of epithelium." [] synonym: "abnormality of basal lamina of epithelium" EXACT [] is_a: PLANP:0000381 ! abnormal integumental system [Term] id: PLANP:0000083 name: abnormal mechanoreceptor cell def: "Abnormality of mechanoreceptor cell." [] synonym: "abnormality of mechanoreceptor cell" EXACT [] is_a: PLANP:0000416 ! abnormal sensory neuron [Term] id: PLANP:0000084 name: abnormal Stage 6 def: "Abnormality of Stage 6." [] synonym: "abnormality of Stage 6" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000085 name: abnormal pharynx outer nerve plexus def: "Abnormality of pharynx outer nerve plexus." [] synonym: "abnormality of pharynx outer nerve plexus" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000352 ! abnormal nerve plexus [Term] id: PLANP:0000086 name: obsolete abnormal cytoskeleton organization comment: term is not needed. [Term] id: PLANP:0000087 name: obsolete abnormal anatomical compartment subdivision feature comment: extra layer of complexity not needed upon further examination [Term] id: PLANP:0000088 name: abnormal peripheral nervous system neuron def: "Abnormality of peripheral nervous system neuron." [] synonym: "abnormality of peripheral nervous system neuron" EXACT [] is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000090 name: abnormal embryonic digestive system def: "Abnormality of embryonic digestive system." [] synonym: "abnormality of embryonic digestive system" EXACT [] is_a: PLANP:0000138 ! abnormal extraembryonic structure [Term] id: PLANP:0000091 name: abnormal muscle cell def: "Abnormality of muscle cell." [] synonym: "abnormality of muscle cell" EXACT [] is_a: PLANP:0000183 ! abnormal electrically responsive cell [Term] id: PLANP:0000092 name: abnormal dopaminergic neuron def: "Abnormality of dopaminergic neuron." [] synonym: "abnormality of dopaminergic neuron" EXACT [] is_a: PLANP:0000309 ! abnormal neurosecretory neuron [Term] id: PLANP:0000093 name: abnormal aboral hemisphere def: "Abnormality of aboral hemisphere." [] synonym: "abnormality of aboral hemisphere" EXACT [] is_a: PLANP:0000307 ! abnormal embryonic subdivision [Term] id: PLANP:0000094 name: abnormal cell-cell adhesion def: "Abnormality of cell-cell adhesion." [] synonym: "abnormality of cell-cell adhesion" EXACT [] is_a: PLANP:0000110 ! abnormal cell-cell contact zone [Term] id: PLANP:0000095 name: abnormal nuclear pore def: "Abnormality of nuclear pore." [] synonym: "abnormality of nuclear pore" EXACT [] is_a: PLANP:0000170 ! abnormal nuclear part is_a: PLANP:0000628 ! abnormal pore [Term] id: PLANP:0000096 name: abnormal sensory cell def: "Abnormality of sensory cell." [] synonym: "abnormality of sensory cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000097 name: abnormal ribosome def: "Abnormality of ribosome." [] synonym: "abnormality of ribosome" EXACT [] is_a: PLANP:0000067 ! abnormal intracellular non-membrane-bounded organelle [Term] id: PLANP:0000098 name: obsolete abnormal acellular anatomical structure comment: extra layer of complexity not needed upon further examination [Term] id: PLANP:0000099 name: abnormal gamma neoblast def: "Abnormality of gamma neoblast." [] synonym: "abnormality of gamma neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000285 ! abnormal digestive system [Term] id: PLANP:0000102 name: obsolete abnormal parenchymal compartment comment: no longer designating mediolateral regions using the contained_in object property [Term] id: PLANP:0000103 name: abnormal posterior pole def: "Abnormality of posterior pole." [] synonym: "abnormality of posterior pole" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000104 name: abnormal oocyte def: "Abnormality of oocyte." [] synonym: "abnormality of oocyte" EXACT [] is_a: PLANP:0000108 ! abnormal gamete is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000437 ! abnormal female germ cell [Term] id: PLANP:0000105 name: abnormal sperm duct epithelium def: "Abnormality of sperm duct epithelium." [] synonym: "abnormality of sperm duct epithelium" EXACT [] is_a: PLANP:0000151 ! abnormal sperm duct is_a: PLANP:0000573 ! abnormal ciliated epithelium [Term] id: PLANP:0000108 name: abnormal gamete def: "Abnormality of gamete." [] synonym: "abnormality of gamete" EXACT [] is_a: PLANP:0000032 ! abnormal reproductive system product is_a: PLANP:0000288 ! abnormal germ cell [Term] id: PLANP:0000109 name: abnormal embryonic pharynx def: "Abnormality of embryonic pharynx." [] synonym: "abnormality of embryonic pharynx" EXACT [] is_a: PLANP:0000090 ! abnormal embryonic digestive system is_a: PLANP:0000667 ! abnormal extraembryonic organ [Term] id: PLANP:0000110 name: abnormal cell-cell contact zone def: "Abnormality of cell-cell contact zone." [] synonym: "abnormality of cell-cell contact zone" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000111 name: abnormal releasing gland cell def: "Abnormality of releasing gland cell." [] synonym: "abnormality of releasing gland cell" EXACT [] is_a: PLANP:0000140 ! abnormal adhesion gland is_a: PLANP:0000291 ! abnormal acidophilic gland cell [Term] id: PLANP:0000112 name: abnormal testis somatic gonadal cell def: "Abnormality of testis somatic gonadal cell." [] synonym: "abnormality of testis somatic gonadal cell" EXACT [] is_a: PLANP:0000280 ! abnormal testis is_a: PLANP:0000645 ! abnormal somatic gonadal cell [Term] id: PLANP:0000113 name: abnormal bursal canal def: "Abnormality of bursal canal." [] synonym: "abnormality of bursal canal" EXACT [] is_a: PLANP:0000065 ! abnormal copulatory apparatus is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000114 name: abnormal lateral branch def: "Abnormality of lateral branch." [] synonym: "abnormality of lateral branch" EXACT [] is_a: PLANP:0000149 ! abnormal cephalic ganglia is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000115 name: abnormal dorsal stripe def: "Abnormality of dorsal stripe." [] synonym: "abnormality of dorsal stripe" EXACT [] is_a: PLANP:0000135 ! abnormal dorsal epidermis is_a: PLANP:0000573 ! abnormal ciliated epithelium [Term] id: PLANP:0000116 name: abnormal embryonic structure def: "Abnormality of embryonic structure." [] synonym: "abnormality of embryonic structure" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000117 name: abnormal epidermal progenitor cell def: "Abnormality of epidermal progenitor cell." [] synonym: "abnormality of epidermal progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000119 name: abnormal chromatin def: "Abnormality of chromatin." [] synonym: "abnormality of chromatin" EXACT [] is_a: PLANP:0000170 ! abnormal nuclear part [Term] id: PLANP:0000121 name: abnormal Stage 4 def: "Abnormality of Stage 4." [] synonym: "abnormality of Stage 4" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000122 name: abnormal anchor cell def: "Abnormality of anchor cell." [] synonym: "abnormality of anchor cell" EXACT [] is_a: PLANP:0000140 ! abnormal adhesion gland is_a: PLANP:0000291 ! abnormal acidophilic gland cell [Term] id: PLANP:0000124 name: abnormal klf+ sensory neuron progenitor cell def: "Abnormality of klf+ sensory neuron progenitor cell." [] synonym: "abnormality of klf+ sensory neuron progenitor cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000143 ! abnormal neural progenitor is_a: PLANP:0000365 ! abnormal peripheral nervous system [Term] id: PLANP:0000125 name: abnormal optic chiasm def: "Abnormality of optic chiasm." [] synonym: "abnormality of optic chiasm" EXACT [] is_a: PLANP:0000198 ! abnormal visual system is_a: PLANP:0000258 ! abnormal neuron projection bundle [Term] id: PLANP:0000126 name: abnormal primitive ectoderm cell def: "Abnormality of primitive ectoderm cell." [] synonym: "abnormality of primitive ectoderm cell" EXACT [] is_a: PLANP:0000059 ! abnormal extraembryonic cell is_a: PLANP:0000150 ! abnormal ciliated epithelial cell is_a: PLANP:0000435 ! abnormal primitive ectoderm [Term] id: PLANP:0000127 name: abnormal oviduct epithelial cell def: "Abnormality of oviduct epithelial cell." [] synonym: "abnormality of oviduct epithelial cell" EXACT [] is_a: PLANP:0000150 ! abnormal ciliated epithelial cell is_a: PLANP:0000279 ! abnormal oviduct epithelium [Term] id: PLANP:0000128 name: abnormal male germ cell def: "Abnormality of male germ cell." [] synonym: "abnormality of male germ cell" EXACT [] is_a: PLANP:0000288 ! abnormal germ cell [Term] id: PLANP:0000129 name: abnormal longitudinal muscle cell def: "Abnormality of longitudinal muscle cell." [] synonym: "abnormality of longitudinal muscle cell" EXACT [] is_a: PLANP:0000091 ! abnormal muscle cell is_a: PLANP:0000392 ! abnormal body wall musculature [Term] id: PLANP:0000130 name: abnormal oral opening def: "Abnormality of oral opening." [] synonym: "abnormality of oral opening" EXACT [] is_a: PLANP:0000109 ! abnormal embryonic pharynx is_a: PLANP:0000439 ! abnormal mouth [Term] id: PLANP:0000131 name: abnormal membrane-bounded organelle def: "Abnormality of membrane-bounded organelle." [] synonym: "abnormality of membrane-bounded organelle" EXACT [] is_a: PLANP:0000306 ! abnormal organelle [Term] id: PLANP:0000132 name: abnormal spermatogonium def: "Abnormality of spermatogonium." [] synonym: "abnormality of spermatogonium" EXACT [] is_a: PLANP:0000128 ! abnormal male germ cell is_a: PLANP:0000280 ! abnormal testis is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000135 name: abnormal dorsal epidermis def: "Abnormality of dorsal region of the epidermis." [] synonym: "abnormality of dorsal region of the epidermis" EXACT [] is_a: PLANP:0000052 ! abnormal ventral epidermis [Term] id: PLANP:0000136 name: abnormal seminal vesicle def: "Abnormality of seminal vesicle." [] synonym: "abnormality of seminal vesicle" EXACT [] is_a: PLANP:0000065 ! abnormal copulatory apparatus is_a: PLANP:0000638 ! abnormal reproductive organ [Term] id: PLANP:0000138 name: abnormal extraembryonic structure def: "Abnormality of extraembryonic structure." [] synonym: "abnormality of extraembryonic structure" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000139 name: abnormal Stage 3 def: "Abnormality of Stage 3." [] synonym: "abnormality of Stage 3" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000140 name: abnormal adhesion gland def: "Abnormality of adhesion gland." [] synonym: "abnormality of adhesion gland" EXACT [] is_a: PLANP:0000372 ! abnormal tissue is_a: PLANP:0000384 ! abnormal secretory system [Term] id: PLANP:0000143 name: abnormal neural progenitor def: "Abnormality of neural progenitor cell." [] synonym: "abnormality of neural progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000144 name: abnormal yolk syncytium def: "Abnormality of yolk syncytium." [] synonym: "abnormality of yolk syncytium" EXACT [] is_a: PLANP:0000681 ! abnormal syncytium [Term] id: PLANP:0000145 name: abnormal plasma membrane def: "Abnormality of plasma membrane." [] synonym: "abnormality of plasma membrane" EXACT [] is_a: PLANP:0000229 ! abnormal membrane [Term] id: PLANP:0000146 name: abnormal cytoplasmic part def: "Abnormality of cytoplasmic part." [] synonym: "abnormality of cytoplasmic part" EXACT [] is_a: PLANP:0000358 ! abnormal intracellular part [Term] id: PLANP:0000147 name: abnormal unipolar neuron def: "Abnormality of unipolar neuron." [] synonym: "abnormality of unipolar neuron" EXACT [] is_a: PLANP:0000416 ! abnormal sensory neuron [Term] id: PLANP:0000149 name: abnormal cephalic ganglia def: "Abnormality of cephalic ganglia." [] synonym: "abnormality of cephalic ganglia" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000238 ! abnormal central nervous system [Term] id: PLANP:0000150 name: abnormal ciliated epithelial cell def: "Abnormality of ciliated epithelial cell." [] synonym: "abnormality of ciliated epithelial cell" EXACT [] is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000151 name: abnormal sperm duct def: "Abnormality of sperm duct." [] synonym: "abnormality of sperm duct" EXACT [] is_a: PLANP:0000638 ! abnormal reproductive organ [Term] id: PLANP:0000152 name: abnormal anterior pole progenitor cell def: "Abnormality of anterior pole progenitor cell." [] synonym: "abnormality of anterior pole progenitor cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000153 name: abnormal anterior-posterior axis def: "Abnormality of anterior-posterior axis of the whole animal." [] synonym: "abnormality of anterior-posterior axis of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000154 name: abnormal plasma membrane part def: "Abnormality of plasma membrane part." [] synonym: "abnormality of plasma membrane part" EXACT [] is_a: PLANP:0000145 ! abnormal plasma membrane is_a: PLANP:0000388 ! abnormal membrane part [Term] id: PLANP:0000155 name: abnormal embryonic pharynx circular muscle cell def: "Abnormality of embryonic pharynx circular muscle cell." [] synonym: "abnormality of embryonic pharynx circular muscle cell" EXACT [] is_a: PLANP:0000059 ! abnormal extraembryonic cell is_a: PLANP:0000091 ! abnormal muscle cell is_a: PLANP:0000109 ! abnormal embryonic pharynx [Term] id: PLANP:0000156 name: abnormal submuscular nerve plexus def: "Abnormality of submuscular nerve plexus." [] synonym: "abnormality of submuscular nerve plexus" EXACT [] is_a: PLANP:0000186 ! abnormal musculature system is_a: PLANP:0000352 ! abnormal nerve plexus [Term] id: PLANP:0000158 name: abnormal female primordial germ cell def: "Abnormality of female primordial germ cell." [] synonym: "abnormality of female primordial germ cell" EXACT [] is_a: PLANP:0000283 ! abnormal stem cell is_a: PLANP:0000437 ! abnormal female germ cell [Term] id: PLANP:0000159 name: abnormal photoreceptor neuron def: "Abnormality of photoreceptor neuron." [] synonym: "abnormality of photoreceptor neuron" EXACT [] is_a: PLANP:0000046 ! abnormal eye is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000160 name: abnormal asexual adult def: "Abnormality of asexual adult." [] synonym: "abnormality of asexual adult" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000161 name: abnormal gonad def: "Abnormality of gonad." [] synonym: "abnormality of gonad" EXACT [] is_a: PLANP:0000638 ! abnormal reproductive organ [Term] id: PLANP:0000164 name: abnormal ventral nerve cord def: "Abnormality of ventral nerve cord." [] synonym: "abnormality of ventral nerve cord" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000238 ! abnormal central nervous system [Term] id: PLANP:0000165 name: abnormal embryonic wall def: "Abnormality of embryonic wall." [] synonym: "abnormality of embryonic wall" EXACT [] is_a: PLANP:0000307 ! abnormal embryonic subdivision [Term] id: PLANP:0000166 name: abnormal testis nerve plexus def: "Abnormality of testis nerve plexus." [] synonym: "abnormality of testis nerve plexus" EXACT [] is_a: PLANP:0000352 ! abnormal nerve plexus is_a: PLANP:0000353 ! abnormal reproductive system [Term] id: PLANP:0000167 name: abnormal pharynx radial muscle cell def: "Abnormality of pharynx radial muscle cell." [] synonym: "abnormality of pharynx radial muscle cell" EXACT [] is_a: PLANP:0000012 ! abnormal pharynx musculature is_a: PLANP:0000091 ! abnormal muscle cell [Term] id: PLANP:0000169 name: abnormal clonogenic neoblast def: "Abnormality of clonogenic neoblast." [] synonym: "abnormality of clonogenic neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000644 ! abnormal somatic cell [Term] id: PLANP:0000170 name: abnormal nuclear part def: "Abnormality of nuclear part." [] synonym: "abnormality of nuclear part" EXACT [] is_a: PLANP:0000200 ! abnormal nucleus [Term] id: PLANP:0000173 name: abnormal sensory system def: "Abnormality of sensory system." [] synonym: "abnormality of sensory system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000175 name: abnormal gut def: "Abnormality of gut." [] synonym: "abnormality of gut" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000285 ! abnormal digestive system [Term] id: PLANP:0000177 name: abnormal dorsal ventral margin def: "Abnormality of dorsal ventral margin of the whole animal." [] synonym: "abnormality of dorsal ventral margin of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000179 name: abnormal ovary def: "Abnormality of ovary." [] synonym: "abnormality of ovary" EXACT [] is_a: PLANP:0000161 ! abnormal gonad [Term] id: PLANP:0000181 name: abnormal GABAergic neuron def: "Abnormality of GABAergic neuron." [] synonym: "abnormality of GABAergic neuron" EXACT [] is_a: PLANP:0000309 ! abnormal neurosecretory neuron [Term] id: PLANP:0000183 name: abnormal electrically responsive cell def: "Abnormality of electrically responsive cell." [] synonym: "abnormality of electrically responsive cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000185 name: abnormal pharynx pouch def: "Abnormality of pharynx pouch." [] synonym: "abnormality of pharynx pouch" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000186 name: abnormal musculature system def: "Abnormality of musculature system." [] synonym: "abnormality of musculature system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000187 name: abnormal actin-based cell projection def: "Abnormality of actin-based cell projection." [] synonym: "abnormality of actin-based cell projection" EXACT [] is_a: PLANP:0000366 ! abnormal cell projection [Term] id: PLANP:0000188 name: abnormal efferent neuron def: "Abnormality of efferent neuron." [] synonym: "abnormality of efferent neuron" EXACT [] is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000191 name: abnormal embryonic pharynx lumen def: "Abnormality of embryonic pharynx lumen." [] synonym: "abnormality of embryonic pharynx lumen" EXACT [] is_a: PLANP:0000109 ! abnormal embryonic pharynx is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000192 name: abnormal non-membrane-bounded organelle def: "Abnormality of non-membrane-bounded organelle." [] synonym: "abnormality of non-membrane-bounded organelle" EXACT [] is_a: PLANP:0000306 ! abnormal organelle [Term] id: PLANP:0000193 name: abnormal parapharyngeal region def: "Abnormality of parapharyngeal region." [] synonym: "abnormality of parapharyngeal region" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000194 name: abnormal oral hemisphere def: "Abnormality of oral hemisphere." [] synonym: "abnormality of oral hemisphere" EXACT [] is_a: PLANP:0000307 ! abnormal embryonic subdivision [Term] id: PLANP:0000196 name: abnormal electrically signaling cell def: "Abnormality of electrically signaling cell." [] synonym: "abnormality of electrically signaling cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000198 name: abnormal visual system def: "Abnormality of visual system." [] synonym: "abnormality of visual system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000199 name: abnormal nervous system def: "Abnormality of nervous system." [] synonym: "abnormality of nervous system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000200 name: abnormal nucleus def: "Abnormality of nucleus." [] synonym: "abnormality of nucleus" EXACT [] is_a: PLANP:0000398 ! abnormal intracellular membrane-bounded organelle [Term] id: PLANP:0000201 name: obsolete abnormal oviparity comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000202 name: abnormal anatomical system def: "Abnormality of anatomical system." [] synonym: "abnormality of anatomical system" EXACT [] is_a: PLANP:0000410 ! abnormal multicellular anatomical structure [Term] id: PLANP:0000204 name: obsolete abnormal protosphere comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000205 name: abnormal gland cell def: "Abnormality of gland cell." [] synonym: "abnormality of gland cell" EXACT [] is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000206 name: abnormal bounding membrane of organelle def: "Abnormality of bounding membrane of organelle." [] synonym: "abnormality of bounding membrane of organelle" EXACT [] is_a: PLANP:0000229 ! abnormal membrane [Term] id: PLANP:0000207 name: abnormal Category 3 cell def: "Abnormality of Category 3 cell." [] synonym: "abnormality of Category 3 cell" EXACT [] is_a: PLANP:0000117 ! abnormal epidermal progenitor cell is_a: PLANP:0000381 ! abnormal integumental system is_a: PLANP:0000644 ! abnormal somatic cell [Term] id: PLANP:0000209 name: abnormal gastrodermis def: "Abnormality of gastrodermis." [] synonym: "abnormality of gastrodermis" EXACT [] is_a: PLANP:0000175 ! abnormal gut is_a: PLANP:0000665 ! abnormal epithelium [Term] id: PLANP:0000211 name: abnormal non ciliated epithelial cell def: "Abnormality of non ciliated epithelial cell." [] synonym: "abnormality of non ciliated epithelial cell" EXACT [] is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000212 name: abnormal pharynx longitudinal muscle cell def: "Abnormality of pharynx longitudinal muscle cell." [] synonym: "abnormality of pharynx longitudinal muscle cell" EXACT [] is_a: PLANP:0000012 ! abnormal pharynx musculature is_a: PLANP:0000091 ! abnormal muscle cell [Term] id: PLANP:0000213 name: abnormal left-right axis def: "Abnormality of left-right axis of the whole animal." [] synonym: "abnormality of left-right axis of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000214 name: abnormal trail cell def: "Abnormality of trail cell." [] synonym: "abnormality of trail cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000198 ! abnormal visual system [Term] id: PLANP:0000215 name: abnormal blastomere def: "Abnormality of blastomere." [] synonym: "abnormality of blastomere" EXACT [] is_a: PLANP:0000379 ! abnormal embryonic cell is_a: PLANP:0000425 ! abnormal ectolecithal embryo [Term] id: PLANP:0000216 name: abnormal oogonial cell def: "Abnormality of oogonial cell." [] synonym: "abnormality of oogonial cell" EXACT [] is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000304 ! abnormal progenitor cell is_a: PLANP:0000437 ! abnormal female germ cell [Term] id: PLANP:0000218 name: abnormal Stage 8 def: "Abnormality of Stage 8." [] synonym: "abnormality of Stage 8" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000219 name: abnormal copulatory region def: "Abnormality of copulatory region." [] synonym: "abnormality of copulatory region" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000220 name: abnormal Golgi apparatus def: "Abnormality of Golgi apparatus." [] synonym: "abnormality of Golgi apparatus" EXACT [] is_a: PLANP:0000398 ! abnormal intracellular membrane-bounded organelle [Term] id: PLANP:0000221 name: abnormal spermatid def: "Abnormality of spermatid." [] synonym: "abnormality of spermatid" EXACT [] is_a: PLANP:0000128 ! abnormal male germ cell is_a: PLANP:0000280 ! abnormal testis [Term] id: PLANP:0000222 name: abnormal definitive organism subdivision def: "Abnormality of definitive organism subdivision." [] synonym: "abnormality of definitive organism subdivision" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000223 name: obsolete abnormal direct development comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000226 name: abnormal vitelline gland def: "Abnormality of vitelline gland." [] synonym: "abnormality of vitelline gland" EXACT [] is_a: PLANP:0000353 ! abnormal reproductive system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000228 name: abnormal embryonic pharynx neuron def: "Abnormality of embryonic pharynx neuron." [] synonym: "abnormality of embryonic pharynx neuron" EXACT [] is_a: PLANP:0000059 ! abnormal extraembryonic cell is_a: PLANP:0000109 ! abnormal embryonic pharynx is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000229 name: abnormal membrane def: "Abnormality of membrane." [] synonym: "abnormality of membrane" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000230 name: abnormal flame cell def: "Abnormality of flame cell." [] synonym: "abnormality of flame cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell is_a: PLANP:0000406 ! abnormal flame bulb [Term] id: PLANP:0000232 name: abnormal cytoplasm def: "Abnormality of cytoplasm." [] synonym: "abnormality of cytoplasm" EXACT [] is_a: PLANP:0000358 ! abnormal intracellular part [Term] id: PLANP:0000233 name: abnormal oral-aboral axis def: "Abnormality of oral-aboral axis of the embryo." [] synonym: "abnormality of oral-aboral axis of the embryo" EXACT [] is_a: PLANP:0000289 ! abnormal embryo [Term] id: PLANP:0000234 name: abnormal zeta neoblast def: "Abnormality of zeta neoblast." [] synonym: "abnormality of zeta neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000117 ! abnormal epidermal progenitor cell is_a: PLANP:0000381 ! abnormal integumental system [Term] id: PLANP:0000236 name: obsolete abnormal tissue morphogenesis comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000237 name: abnormal juvenile def: "Abnormality of juvenile." [] synonym: "abnormality of juvenile" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000238 name: abnormal central nervous system def: "Abnormality of central nervous system." [] synonym: "abnormality of central nervous system" EXACT [] is_a: PLANP:0000199 ! abnormal nervous system [Term] id: PLANP:0000239 name: abnormal pharynx inner circular muscle cell def: "Abnormality of pharynx inner circular muscle cell." [] synonym: "abnormality of pharynx inner circular muscle cell" EXACT [] is_a: PLANP:0000376 ! abnormal pharynx circular muscle cell [Term] id: PLANP:0000240 name: obsolete abnormal gametogenesis comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000241 name: obsolete abnormal body wall musculature compartment comment: no longer designating mediolateral regions using the contained_in object property [Term] id: PLANP:0000242 name: abnormal motor neuron def: "Abnormality of motor neuron." [] synonym: "abnormality of motor neuron" EXACT [] is_a: PLANP:0000188 ! abnormal efferent neuron [Term] id: PLANP:0000243 name: abnormal apical surface of the epidermis def: "Abnormality of apical surface of the epidermis." [] synonym: "abnormality of apical surface of the epidermis" EXACT [] is_a: PLANP:0000427 ! abnormal epidermis [Term] id: PLANP:0000245 name: abnormal tuba def: "Abnormality of tuba." [] synonym: "abnormality of tuba" EXACT [] is_a: PLANP:0000638 ! abnormal reproductive organ [Term] id: PLANP:0000246 name: abnormal posterior primary gut branch def: "Abnormality of posterior primary gut branch." [] synonym: "abnormality of posterior primary gut branch" EXACT [] is_a: PLANP:0000635 ! abnormal primary gut branch [Term] id: PLANP:0000248 name: abnormal epithelial cell component def: "Abnormality of epithelial cell component." [] synonym: "abnormality of epithelial cell component" EXACT [] is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000250 name: abnormal spermatogonial stem cell def: "Abnormality of spermatogonial stem cell." [] synonym: "abnormality of spermatogonial stem cell" EXACT [] is_a: PLANP:0000128 ! abnormal male germ cell is_a: PLANP:0000280 ! abnormal testis is_a: PLANP:0000283 ! abnormal stem cell [Term] id: PLANP:0000251 name: abnormal ovary nerve plexus def: "Abnormality of ovary nerve plexus." [] synonym: "abnormality of ovary nerve plexus" EXACT [] is_a: PLANP:0000352 ! abnormal nerve plexus is_a: PLANP:0000353 ! abnormal reproductive system [Term] id: PLANP:0000252 name: abnormal midline def: "Abnormality of midline." [] synonym: "abnormality of midline" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000254 name: abnormal pharynx inner nerve plexus def: "Abnormality of pharynx inner nerve plexus." [] synonym: "abnormality of pharynx inner nerve plexus" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000352 ! abnormal nerve plexus [Term] id: PLANP:0000255 name: obsolete abnormal ventral compartment comment: now using patterned term ventral region PLANA:0000143 [Term] id: PLANP:0000256 name: abnormal parenchymal musculature def: "Abnormality of parenchymal musculature." [] synonym: "abnormality of parenchymal musculature" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000186 ! abnormal musculature system [Term] id: PLANP:0000258 name: abnormal neuron projection bundle def: "Abnormality of neuron projection bundle." [] synonym: "abnormality of neuron projection bundle" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000364 ! abnormal axon tract is_a: PLANP:0000365 ! abnormal peripheral nervous system [Term] id: PLANP:0000259 name: obsolete abnormal embryonic cleavage comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000260 name: obsolete abnormal definitive anatomical structure comment: extra layer of complexity not needed upon further examination [Term] id: PLANP:0000261 name: abnormal anatomical region def: "Abnormality of anatomical region." [] synonym: "abnormality of anatomical region" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000262 name: obsolete abnormal Schmidtea mediterranea developmental stage comment: this term is not needed. All previous children of this term (Stage 1, Sage 2, etc) are now children of GO life cycle stage or zygote stage [Term] id: PLANP:0000264 name: abnormal Category 2 cell def: "Abnormality of Category 2 cell." [] synonym: "abnormality of Category 2 cell" EXACT [] is_a: PLANP:0000117 ! abnormal epidermal progenitor cell is_a: PLANP:0000381 ! abnormal integumental system is_a: PLANP:0000644 ! abnormal somatic cell [Term] id: PLANP:0000265 name: abnormal cell-cell junction def: "Abnormality of cell-cell junction." [] synonym: "abnormality of cell-cell junction" EXACT [] is_a: PLANP:0000420 ! abnormal cell junction [Term] id: PLANP:0000266 name: abnormal TrpA+ central nervous system neuron def: "Abnormality of TrpA+ central nervous system neuron." [] synonym: "abnormality of TrpA+ central nervous system neuron" EXACT [] is_a: PLANP:0000011 ! abnormal central nervous system neuron is_a: PLANP:0000149 ! abnormal cephalic ganglia [Term] id: PLANP:0000267 name: abnormal smooth endoplasmic reticulum def: "Abnormality of smooth endoplasmic reticulum." [] synonym: "abnormality of smooth endoplasmic reticulum" EXACT [] is_a: PLANP:0000313 ! abnormal endoplasmic reticulum [Term] id: PLANP:0000268 name: abnormal terminally differentiated cell def: "Abnormality of terminally differentiated cell." [] synonym: "abnormality of terminally differentiated cell" EXACT [] is_a: PLANP:0000644 ! abnormal somatic cell [Term] id: PLANP:0000269 name: abnormal basophilic gland cell def: "Abnormality of basophilic gland cell." [] synonym: "abnormality of basophilic gland cell" EXACT [] is_a: PLANP:0000205 ! abnormal gland cell [Term] id: PLANP:0000270 name: abnormal primordium def: "Abnormality of primordium." [] synonym: "abnormality of primordium" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000271 name: abnormal euchromatin def: "Abnormality of euchromatin." [] synonym: "abnormality of euchromatin" EXACT [] is_a: PLANP:0000119 ! abnormal chromatin [Term] id: PLANP:0000275 name: abnormal proximal tubule epithelial cell def: "Abnormality of proximal tubule epithelial cell." [] synonym: "abnormality of proximal tubule epithelial cell" EXACT [] is_a: PLANP:0000042 ! abnormal proximal tubule is_a: PLANP:0000150 ! abnormal ciliated epithelial cell [Term] id: PLANP:0000277 name: abnormal anterior pole def: "Abnormality of anterior pole." [] synonym: "abnormality of anterior pole" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000279 name: abnormal oviduct epithelium def: "Abnormality of oviduct epithelium." [] synonym: "abnormality of oviduct epithelium" EXACT [] is_a: PLANP:0000023 ! abnormal oviduct is_a: PLANP:0000573 ! abnormal ciliated epithelium [Term] id: PLANP:0000280 name: abnormal testis def: "Abnormality of testis." [] synonym: "abnormality of testis" EXACT [] is_a: PLANP:0000161 ! abnormal gonad [Term] id: PLANP:0000281 name: abnormal Category 5 cell def: "Abnormality of Category 5 cell." [] synonym: "abnormality of Category 5 cell" EXACT [] is_a: PLANP:0000135 ! abnormal dorsal epidermis is_a: PLANP:0000150 ! abnormal ciliated epithelial cell is_a: PLANP:0000582 ! abnormal epidermal cell [Term] id: PLANP:0000283 name: abnormal stem cell def: "Abnormality of stem cell." [] synonym: "abnormality of stem cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000285 name: abnormal digestive system def: "Abnormality of digestive system." [] synonym: "abnormality of digestive system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000287 name: abnormal viscid gland cell def: "Abnormality of viscid gland cell." [] synonym: "abnormality of viscid gland cell" EXACT [] is_a: PLANP:0000140 ! abnormal adhesion gland is_a: PLANP:0000291 ! abnormal acidophilic gland cell [Term] id: PLANP:0000288 name: abnormal germ cell def: "Abnormality of germ cell." [] synonym: "abnormality of germ cell" EXACT [] is_a: PLANP:0000353 ! abnormal reproductive system is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000289 name: abnormal embryo def: "Abnormality of embryo." [] synonym: "abnormality of embryo" EXACT [] is_a: PLANP:0000032 ! abnormal reproductive system product [Term] id: PLANP:0000290 name: abnormal anterior commissure def: "Abnormality of anterior commissure." [] synonym: "abnormality of anterior commissure" EXACT [] is_a: PLANP:0000022 ! abnormal brain commissure [Term] id: PLANP:0000291 name: abnormal acidophilic gland cell def: "Abnormality of acidophilic gland cell." [] synonym: "abnormality of acidophilic gland cell" EXACT [] is_a: PLANP:0000205 ! abnormal gland cell [Term] id: PLANP:0000293 name: abnormal tuba lumen def: "Abnormality of tuba lumen." [] synonym: "abnormality of tuba lumen" EXACT [] is_a: PLANP:0000245 ! abnormal tuba is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000294 name: abnormal Stage 5 def: "Abnormality of Stage 5." [] synonym: "abnormality of Stage 5" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000295 name: abnormal embryonic gut cavity def: "Abnormality of embryonic gut cavity." [] synonym: "abnormality of embryonic gut cavity" EXACT [] is_a: PLANP:0000581 ! abnormal embryonic gut [Term] id: PLANP:0000296 name: abnormal pharynx pouch epithelial surface def: "Abnormality of pharynx pouch epithelial surface." [] synonym: "abnormality of pharynx pouch epithelial surface" EXACT [] is_a: PLANP:0000685 ! abnormal pharynx pouch epithelium [Term] id: PLANP:0000297 name: abnormal embryonic gut cell surface def: "Abnormality of embryonic gut cell surface." [] synonym: "abnormality of embryonic gut cell surface" EXACT [] is_a: PLANP:0000076 ! abnormal embryonic gut cell [Term] id: PLANP:0000298 name: abnormal vacuole def: "Abnormality of vacuole." [] synonym: "abnormality of vacuole" EXACT [] is_a: PLANP:0000131 ! abnormal membrane-bounded organelle [Term] id: PLANP:0000299 name: abnormal proximal-distal axis def: "Abnormality of proximal-distal axis of the whole animal." [] synonym: "abnormality of proximal-distal axis of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000301 name: abnormal sperm duct lumen def: "Abnormality of sperm duct lumen." [] synonym: "abnormality of sperm duct lumen" EXACT [] is_a: PLANP:0000151 ! abnormal sperm duct is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000302 name: abnormal neuron associated cell (sensu Nematoda and Protostomia) def: "Abnormality of neuron associated cell (sensu Nematoda and Protostomia)." [] synonym: "abnormality of neuron associated cell (sensu Nematoda and Protostomia)" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000304 name: abnormal progenitor cell def: "Abnormality of progenitor cell." [] synonym: "abnormality of progenitor cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000305 name: abnormal biotype def: "Abnormality of biotype." [] synonym: "abnormality of biotype" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000306 name: abnormal organelle def: "Abnormality of organelle." [] synonym: "abnormality of organelle" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000307 name: abnormal embryonic subdivision def: "Abnormality of embryonic subdivision." [] synonym: "abnormality of embryonic subdivision" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000309 name: abnormal neurosecretory neuron def: "Abnormality of neurosecretory neuron." [] synonym: "abnormality of neurosecretory neuron" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000331 ! abnormal secretory cell is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000310 name: abnormal epithelial cell def: "Abnormality of epithelial cell." [] synonym: "abnormality of epithelial cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000311 name: abnormal serotonergic neuron def: "Abnormality of serotonergic neuron." [] synonym: "abnormality of serotonergic neuron" EXACT [] is_a: PLANP:0000149 ! abnormal cephalic ganglia is_a: PLANP:0000164 ! abnormal ventral nerve cord is_a: PLANP:0000309 ! abnormal neurosecretory neuron [Term] id: PLANP:0000312 name: abnormal muscle progenitor def: "Abnormality of muscle progenitor cell." [] synonym: "abnormality of muscle progenitor cell" EXACT [] is_a: PLANP:0000186 ! abnormal musculature system is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000313 name: abnormal endoplasmic reticulum def: "Abnormality of endoplasmic reticulum." [] synonym: "abnormality of endoplasmic reticulum" EXACT [] is_a: PLANP:0000398 ! abnormal intracellular membrane-bounded organelle [Term] id: PLANP:0000314 name: abnormal distal tubule def: "Abnormality of distal tubule." [] synonym: "abnormality of distal tubule" EXACT [] is_a: PLANP:0000079 ! abnormal protonephridia is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000315 name: abnormal copulatory bursa def: "Abnormality of copulatory bursa." [] synonym: "abnormality of copulatory bursa" EXACT [] is_a: PLANP:0000065 ! abnormal copulatory apparatus is_a: PLANP:0000638 ! abnormal reproductive organ [Term] id: PLANP:0000317 name: abnormal esophagus def: "Abnormality of esophagus." [] synonym: "abnormality of esophagus" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000318 name: abnormal secondary gut branch def: "Abnormality of secondary gut branch." [] synonym: "abnormality of secondary gut branch" EXACT [] is_a: PLANP:0000666 ! abnormal gut branch [Term] id: PLANP:0000320 name: abnormal Stage 2 def: "Abnormality of Stage 2." [] synonym: "abnormality of Stage 2" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000322 name: abnormal protonephridial progenitor def: "Abnormality of protonephridial progenitor cell." [] synonym: "abnormality of protonephridial progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000323 name: abnormal ventral midline def: "Abnormality of ventral midline." [] synonym: "abnormality of ventral midline" EXACT [] is_a: PLANP:0000252 ! abnormal midline [Term] id: PLANP:0000324 name: obsolete abnormal sphere formation comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000326 name: obsolete abnormal basophilic cytoplasm comment: term is not needed. [Term] id: PLANP:0000327 name: abnormal primtive gut cell surface def: "Abnormality of primtive gut cell surface." [] synonym: "abnormality of primtive gut cell surface" EXACT [] is_a: PLANP:0000421 ! abnormal primitive gut cell [Term] id: PLANP:0000329 name: abnormal egg capsule def: "Abnormality of egg capsule." [] synonym: "abnormality of egg capsule" EXACT [] is_a: PLANP:0000032 ! abnormal reproductive system product [Term] id: PLANP:0000330 name: abnormal multipolar neuron def: "Abnormality of multipolar neuron." [] synonym: "abnormality of multipolar neuron" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000336 ! abnormal subepidermal nerve plexus is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000331 name: abnormal secretory cell def: "Abnormality of secretory cell." [] synonym: "abnormality of secretory cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000332 name: abnormal pharynx outer longitudinal muscle cell def: "Abnormality of pharynx outer longitudinal muscle cell." [] synonym: "abnormality of pharynx outer longitudinal muscle cell" EXACT [] is_a: PLANP:0000212 ! abnormal pharynx longitudinal muscle cell [Term] id: PLANP:0000333 name: abnormal penis papilla def: "Abnormality of penis papilla." [] synonym: "abnormality of penis papilla" EXACT [] is_a: PLANP:0000065 ! abnormal copulatory apparatus is_a: PLANP:0000638 ! abnormal reproductive organ [Term] id: PLANP:0000334 name: abnormal TrpA+ neural progenitor cell def: "Abnormality of TrpA+ neural progenitor cell." [] synonym: "abnormality of TrpA+ neural progenitor cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000143 ! abnormal neural progenitor is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system [Term] id: PLANP:0000335 name: abnormal interneuron def: "Abnormality of interneuron." [] synonym: "abnormality of interneuron" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000336 name: abnormal subepidermal nerve plexus def: "Abnormality of subepidermal nerve plexus." [] synonym: "abnormality of subepidermal nerve plexus" EXACT [] is_a: PLANP:0000352 ! abnormal nerve plexus is_a: PLANP:0000381 ! abnormal integumental system [Term] id: PLANP:0000338 name: abnormal longitudinal muscle progenitor cell def: "Abnormality of longitudinal muscle progenitor cell." [] synonym: "abnormality of longitudinal muscle progenitor cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000312 ! abnormal muscle progenitor [Term] id: PLANP:0000339 name: abnormal microvillus def: "Abnormality of microvillus." [] synonym: "abnormality of microvillus" EXACT [] is_a: PLANP:0000187 ! abnormal actin-based cell projection [Term] id: PLANP:0000340 name: abnormal adult hermaphrodite def: "Abnormality of adult hermaphrodite." [] synonym: "abnormality of adult hermaphrodite" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000341 name: abnormal mitochondrion def: "Abnormality of mitochondrion." [] synonym: "abnormality of mitochondrion" EXACT [] is_a: PLANP:0000398 ! abnormal intracellular membrane-bounded organelle [Term] id: PLANP:0000342 name: abnormal enteric musculature def: "Abnormality of enteric musculature." [] synonym: "abnormality of enteric musculature" EXACT [] is_a: PLANP:0000285 ! abnormal digestive system is_a: PLANP:0000409 ! abnormal visceral musculature [Term] id: PLANP:0000344 name: obsolete abnormal coronal plane comment: let odk import from BSPO if needed [Term] id: PLANP:0000345 name: abnormal dorsal midline def: "Abnormality of dorsal midline." [] synonym: "abnormality of dorsal midline" EXACT [] is_a: PLANP:0000323 ! abnormal ventral midline [Term] id: PLANP:0000346 name: abnormal ganglion def: "Abnormality of ganglion." [] synonym: "abnormality of ganglion" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000348 name: abnormal pharynx lumen epithelial surface def: "Abnormality of pharynx inner epithelium surface." [] synonym: "abnormality of pharynx inner epithelium surface" EXACT [] is_a: PLANP:0000396 ! abnormal pharynx inner epithelium [Term] id: PLANP:0000349 name: abnormal sperm def: "Abnormality of sperm." [] synonym: "abnormality of sperm" EXACT [] is_a: PLANP:0000108 ! abnormal gamete is_a: PLANP:0000128 ! abnormal male germ cell is_a: PLANP:0000280 ! abnormal testis [Term] id: PLANP:0000350 name: abnormal serotonergic neural progenitor cell def: "Abnormality of serotonergic neural progenitor cell." [] synonym: "abnormality of serotonergic neural progenitor cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000143 ! abnormal neural progenitor is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system [Term] id: PLANP:0000352 name: abnormal nerve plexus def: "Abnormality of nerve plexus." [] synonym: "abnormality of nerve plexus" EXACT [] is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000353 name: abnormal reproductive system def: "Abnormality of reproductive system." [] synonym: "abnormality of reproductive system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000354 name: abnormal afferent neuron def: "Abnormality of afferent neuron." [] synonym: "abnormality of afferent neuron" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000355 name: abnormal neuropil def: "Abnormality of neuropil." [] synonym: "abnormality of neuropil" EXACT [] is_a: PLANP:0000149 ! abnormal cephalic ganglia is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000356 name: abnormal intestinal phagocyte def: "Abnormality of intestinal phagocyte." [] synonym: "abnormality of intestinal phagocyte" EXACT [] is_a: PLANP:0000209 ! abnormal gastrodermis is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000357 name: abnormal anterior primary gut branch def: "Abnormality of anterior primary gut branch." [] synonym: "abnormality of anterior primary gut branch" EXACT [] is_a: PLANP:0000635 ! abnormal primary gut branch [Term] id: PLANP:0000358 name: abnormal intracellular part def: "Abnormality of intracellular part." [] synonym: "abnormality of intracellular part" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000359 name: obsolete abnormal epidermal compartment comment: no longer designating mediolateral regions using the contained_in object property [Term] id: PLANP:0000360 name: abnormal digestive tract lumen def: "Abnormality of digestive tract lumen." [] synonym: "abnormality of digestive tract lumen" EXACT [] is_a: PLANP:0000175 ! abnormal gut is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000361 name: obsolete abnormal pharynx nerve plexus comment: causes problems with is a and part of relationships for inner and outer pharynx nerve plexus in that both are true. [Term] id: PLANP:0000363 name: abnormal cell def: "Abnormality of cell." [] synonym: "abnormality of cell" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000364 name: abnormal axon tract def: "Abnormality of axon tract." [] synonym: "abnormality of axon tract" EXACT [] is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000365 name: abnormal peripheral nervous system def: "Abnormality of peripheral nervous system." [] synonym: "abnormality of peripheral nervous system" EXACT [] is_a: PLANP:0000199 ! abnormal nervous system [Term] id: PLANP:0000366 name: abnormal cell projection def: "Abnormality of cell projection." [] synonym: "abnormality of cell projection" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000367 name: abnormal commissural neuron def: "Abnormality of commissural neuron." [] synonym: "abnormality of commissural neuron" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000370 name: abnormal pax3/7+ neural progenitor cell def: "Abnormality of pax3/7+ neural progenitor cell." [] synonym: "abnormality of pax3/7+ neural progenitor cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000143 ! abnormal neural progenitor is_a: PLANP:0000238 ! abnormal central nervous system [Term] id: PLANP:0000372 name: abnormal tissue def: "Abnormality of tissue." [] synonym: "abnormality of tissue" EXACT [] is_a: PLANP:0000410 ! abnormal multicellular anatomical structure [Term] id: PLANP:0000373 name: abnormal intracellular organelle def: "Abnormality of intracellular organelle." [] synonym: "abnormality of intracellular organelle" EXACT [] is_a: PLANP:0000358 ! abnormal intracellular part [Term] id: PLANP:0000374 name: abnormal secretory vesicle def: "Abnormality of secretory vesicle." [] synonym: "abnormality of secretory vesicle" EXACT [] is_a: PLANP:0000398 ! abnormal intracellular membrane-bounded organelle [Term] id: PLANP:0000375 name: abnormal optic cup def: "Abnormality of optic cup." [] synonym: "abnormality of optic cup" EXACT [] is_a: PLANP:0000046 ! abnormal eye is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000376 name: abnormal pharynx circular muscle cell def: "Abnormality of pharynx circular muscle cell." [] synonym: "abnormality of pharynx circular muscle cell" EXACT [] is_a: PLANP:0000012 ! abnormal pharynx musculature is_a: PLANP:0000091 ! abnormal muscle cell [Term] id: PLANP:0000378 name: abnormal enteric neuron def: "Abnormality of enteric neuron." [] synonym: "abnormality of enteric neuron" EXACT [] is_a: PLANP:0000070 ! abnormal autonomic neuron [Term] id: PLANP:0000379 name: abnormal embryonic cell def: "Abnormality of embryonic cell." [] synonym: "abnormality of embryonic cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000380 name: abnormal Smed asexual biotype def: "Abnormality of Smed asexual biotype." [] synonym: "abnormality of Smed asexual biotype" EXACT [] is_a: PLANP:0000305 ! abnormal biotype [Term] id: PLANP:0000381 name: abnormal integumental system def: "Abnormality of integumental system." [] synonym: "abnormality of integumental system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000383 name: abnormal cement gland def: "Abnormality of cement gland." [] synonym: "abnormality of cement gland" EXACT [] is_a: PLANP:0000065 ! abnormal copulatory apparatus is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000384 name: abnormal secretory system def: "Abnormality of secretory system." [] synonym: "abnormality of secretory system" EXACT [] is_a: PLANP:0000202 ! abnormal anatomical system [Term] id: PLANP:0000386 name: abnormal elongate spermatid def: "Abnormality of elongate spermatid." [] synonym: "abnormality of elongate spermatid" EXACT [] is_a: PLANP:0000221 ! abnormal spermatid [Term] id: PLANP:0000387 name: abnormal lysosome def: "Abnormality of lysosome." [] synonym: "abnormality of lysosome" EXACT [] is_a: PLANP:0000398 ! abnormal intracellular membrane-bounded organelle [Term] id: PLANP:0000388 name: abnormal membrane part def: "Abnormality of membrane part." [] synonym: "abnormality of membrane part" EXACT [] is_a: PLANP:0000229 ! abnormal membrane [Term] id: PLANP:0000391 name: abnormal Stage 7 def: "Abnormality of Stage 7." [] synonym: "abnormality of Stage 7" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000392 name: abnormal body wall musculature def: "Abnormality of body wall musculature." [] synonym: "abnormality of body wall musculature" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000186 ! abnormal musculature system [Term] id: PLANP:0000393 name: abnormal dorsal-ventral axis def: "Abnormality of dorsal-ventral axis of the whole animal." [] synonym: "abnormality of dorsal-ventral axis of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000394 name: abnormal embryonic pharynx lumen epithelial surface def: "Abnormality of embryonic pharynx lumen epithelial surface." [] synonym: "abnormality of embryonic pharynx lumen epithelial surface" EXACT [] is_a: PLANP:0000109 ! abnormal embryonic pharynx [Term] id: PLANP:0000396 name: abnormal pharynx inner epithelium def: "Abnormality of pharynx inner epithelium." [] synonym: "abnormality of pharynx inner epithelium" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000573 ! abnormal ciliated epithelium [Term] id: PLANP:0000397 name: abnormal circular muscle cell def: "Abnormality of circular muscle cell." [] synonym: "abnormality of circular muscle cell" EXACT [] is_a: PLANP:0000091 ! abnormal muscle cell is_a: PLANP:0000392 ! abnormal body wall musculature [Term] id: PLANP:0000398 name: abnormal intracellular membrane-bounded organelle def: "Abnormality of intracellular membrane-bounded organelle." [] synonym: "abnormality of intracellular membrane-bounded organelle" EXACT [] is_a: PLANP:0000131 ! abnormal membrane-bounded organelle is_a: PLANP:0000373 ! abnormal intracellular organelle [Term] id: PLANP:0000399 name: abnormal oogonial stem cell def: "Abnormality of oogonial stem cell." [] synonym: "abnormality of oogonial stem cell" EXACT [] is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000283 ! abnormal stem cell is_a: PLANP:0000437 ! abnormal female germ cell [Term] id: PLANP:0000403 name: abnormal octopaminergic neuron def: "Abnormality of octopaminergic neuron." [] synonym: "abnormality of octopaminergic neuron" EXACT [] is_a: PLANP:0000309 ! abnormal neurosecretory neuron [Term] id: PLANP:0000404 name: abnormal gonopore def: "Abnormality of gonopore." [] synonym: "abnormality of gonopore" EXACT [] is_a: PLANP:0000065 ! abnormal copulatory apparatus is_a: PLANP:0000628 ! abnormal pore [Term] id: PLANP:0000406 name: abnormal flame bulb def: "Abnormality of flame bulb." [] synonym: "abnormality of flame bulb" EXACT [] is_a: PLANP:0000079 ! abnormal protonephridia is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000407 name: abnormal cholinergic neuron def: "Abnormality of cholinergic neuron." [] synonym: "abnormality of cholinergic neuron" EXACT [] is_a: PLANP:0000309 ! abnormal neurosecretory neuron [Term] id: PLANP:0000409 name: abnormal visceral musculature def: "Abnormality of visceral musculature." [] synonym: "abnormality of visceral musculature" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000186 ! abnormal musculature system [Term] id: PLANP:0000410 name: abnormal multicellular anatomical structure def: "Abnormality of multicellular anatomical structure." [] synonym: "abnormality of multicellular anatomical structure" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000411 name: abnormal tertiary gut branch def: "Abnormality of tertiary gut branch." [] synonym: "abnormality of tertiary gut branch" EXACT [] is_a: PLANP:0000666 ! abnormal gut branch [Term] id: PLANP:0000412 name: abnormal lateral nerve def: "Abnormality of lateral nerve." [] synonym: "abnormality of lateral nerve" EXACT [] is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000413 name: abnormal pharynx outer circular muscle cell def: "Abnormality of pharynx outer circular muscle cell." [] synonym: "abnormality of pharynx outer circular muscle cell" EXACT [] is_a: PLANP:0000376 ! abnormal pharynx circular muscle cell [Term] id: PLANP:0000415 name: abnormal transverse commissure def: "Abnormality of transverse commissure." [] synonym: "abnormality of transverse commissure" EXACT [] is_a: PLANP:0000164 ! abnormal ventral nerve cord is_a: PLANP:0000575 ! abnormal commissure [Term] id: PLANP:0000416 name: abnormal sensory neuron def: "Abnormality of sensory neuron." [] synonym: "abnormality of sensory neuron" EXACT [] is_a: PLANP:0000096 ! abnormal sensory cell is_a: PLANP:0000354 ! abnormal afferent neuron [Term] id: PLANP:0000417 name: abnormal gastrodermal plexus def: "Abnormality of gastrodermal plexus." [] synonym: "abnormality of gastrodermal plexus" EXACT [] is_a: PLANP:0000285 ! abnormal digestive system is_a: PLANP:0000352 ! abnormal nerve plexus [Term] id: PLANP:0000420 name: abnormal cell junction def: "Abnormality of cell junction." [] synonym: "abnormality of cell junction" EXACT [] is_a: PLANP:0000110 ! abnormal cell-cell contact zone [Term] id: PLANP:0000421 name: abnormal primitive gut cell def: "Abnormality of primitive gut cell." [] synonym: "abnormality of primitive gut cell" EXACT [] is_a: PLANP:0000059 ! abnormal extraembryonic cell is_a: PLANP:0000636 ! abnormal primitive gut [Term] id: PLANP:0000425 name: abnormal ectolecithal embryo def: "Abnormality of ectolecithal embryo." [] synonym: "abnormality of ectolecithal embryo" EXACT [] is_a: PLANP:0000289 ! abnormal embryo [Term] id: PLANP:0000427 name: abnormal epidermis def: "Abnormality of epidermis." [] synonym: "abnormality of epidermis" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000381 ! abnormal integumental system [Term] id: PLANP:0000430 name: abnormal nu neoblast def: "Abnormality of nu neoblast." [] synonym: "abnormality of nu neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000143 ! abnormal neural progenitor is_a: PLANP:0000199 ! abnormal nervous system [Term] id: PLANP:0000433 name: abnormal ovarian somatic gonadal cell def: "Abnormality of ovarian somatic gonadal cell." [] synonym: "abnormality of ovarian somatic gonadal cell" EXACT [] is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000434 name: abnormal sperm duct epithelial cell def: "Abnormality of sperm duct epithelial cell." [] synonym: "abnormality of sperm duct epithelial cell" EXACT [] is_a: PLANP:0000105 ! abnormal sperm duct epithelium is_a: PLANP:0000150 ! abnormal ciliated epithelial cell [Term] id: PLANP:0000435 name: abnormal primitive ectoderm def: "Abnormality of primitive ectoderm." [] synonym: "abnormality of primitive ectoderm" EXACT [] is_a: PLANP:0000667 ! abnormal extraembryonic organ [Term] id: PLANP:0000436 name: abnormal pharynx outer epithelium def: "Abnormality of pharynx outer epithelium." [] synonym: "abnormality of pharynx outer epithelium" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000573 ! abnormal ciliated epithelium [Term] id: PLANP:0000437 name: abnormal female germ cell def: "Abnormality of female germ cell." [] synonym: "abnormality of female germ cell" EXACT [] is_a: PLANP:0000288 ! abnormal germ cell [Term] id: PLANP:0000438 name: abnormal collecting duct epithelial cell def: "Abnormality of collecting duct epithelial cell." [] synonym: "abnormality of collecting duct epithelial cell" EXACT [] is_a: PLANP:0000014 ! abnormal collecting duct is_a: PLANP:0000211 ! abnormal non ciliated epithelial cell [Term] id: PLANP:0000439 name: abnormal mouth def: "Abnormality of mouth." [] synonym: "abnormality of mouth" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000285 ! abnormal digestive system [Term] id: PLANP:0000442 name: abnormal circular muscle progenitor cell def: "Abnormality of circular muscle progenitor cell." [] synonym: "abnormality of circular muscle progenitor cell" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast is_a: PLANP:0000312 ! abnormal muscle progenitor is_a: PLANP:0000644 ! abnormal somatic cell [Term] id: PLANP:0000443 name: abnormal embryonic pharynx epithelial cell def: "Abnormality of embryonic pharynx epithelial cell." [] synonym: "abnormality of embryonic pharynx epithelial cell" EXACT [] is_a: PLANP:0000059 ! abnormal extraembryonic cell is_a: PLANP:0000109 ! abnormal embryonic pharynx is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000444 name: abnormal pharynx pouch cavity def: "Abnormality of pharynx pouch cavity." [] synonym: "abnormality of pharynx pouch cavity" EXACT [] is_a: PLANP:0000185 ! abnormal pharynx pouch [Term] id: PLANP:0000445 name: abnormal spermatocyte def: "Abnormality of spermatocyte." [] synonym: "abnormality of spermatocyte" EXACT [] is_a: PLANP:0000128 ! abnormal male germ cell is_a: PLANP:0000280 ! abnormal testis [Term] id: PLANP:0000448 name: abnormal pharynx progenitor cell def: "Abnormality of pharynx progenitor cell." [] synonym: "abnormality of pharynx progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000449 name: obsolete abnormal racing stripe comment: racing stripe is now a synonym of PLANA:0000055 dorsal stripe [Term] id: PLANP:0000450 name: abnormal excitatory motor neuron def: "Abnormality of excitatory motor neuron." [] synonym: "abnormality of excitatory motor neuron" EXACT [] is_a: PLANP:0000088 ! abnormal peripheral nervous system neuron is_a: PLANP:0000242 ! abnormal motor neuron [Term] id: PLANP:0000452 name: abnormal neuron def: "Abnormality of neuron." [] synonym: "abnormality of neuron" EXACT [] is_a: PLANP:0000196 ! abnormal electrically signaling cell [Term] id: PLANP:0000455 name: abnormal diagonal muscle cell def: "Abnormality of diagonal muscle cell." [] synonym: "abnormality of diagonal muscle cell" EXACT [] is_a: PLANP:0000091 ! abnormal muscle cell is_a: PLANP:0000392 ! abnormal body wall musculature [Term] id: PLANP:0000456 name: abnormal nerve def: "Abnormality of nerve." [] synonym: "abnormality of nerve" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000458 name: abnormal sympathetic neuron def: "Abnormality of sympathetic neuron." [] synonym: "abnormality of sympathetic neuron" EXACT [] is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000459 name: obsolete abnormal cross-fertilization comment: removing all processes. may bring back if PLANA expanded to cover processes. [Term] id: PLANP:0000461 name: abnormal secretory pore def: "Abnormality of secretory pore." [] synonym: "abnormality of secretory pore" EXACT [] is_a: PLANP:0000628 ! abnormal pore [Term] id: PLANP:0000462 name: abnormal blastema def: "Abnormality of blastema." [] synonym: "abnormality of blastema" EXACT [] is_a: PLANP:0000678 ! abnormal regenerating fragment [Term] id: PLANP:0000463 name: abnormal embryonic pharynx radial muscle cell def: "Abnormality of embryonic pharynx radial muscle cell." [] synonym: "abnormality of embryonic pharynx radial muscle cell" EXACT [] is_a: PLANP:0000059 ! abnormal extraembryonic cell is_a: PLANP:0000091 ! abnormal muscle cell is_a: PLANP:0000109 ! abnormal embryonic pharynx [Term] id: PLANP:0000464 name: abnormal organelle membrane def: "Abnormality of organelle membrane." [] synonym: "abnormality of organelle membrane" EXACT [] is_a: PLANP:0000131 ! abnormal membrane-bounded organelle is_a: PLANP:0000229 ! abnormal membrane [Term] id: PLANP:0000465 name: abnormal pharynx outer epithelium surface def: "Abnormality of pharynx outer epithelium surface." [] synonym: "abnormality of pharynx outer epithelium surface" EXACT [] is_a: PLANP:0000436 ! abnormal pharynx outer epithelium [Term] id: PLANP:0000467 name: abnormal morphology of primitive ectoderm surface def: "Any unspecified morphological anomaly of the primitive ectoderm surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of primitive ectoderm surface" EXACT [] is_a: PLANP:0000027 ! abnormal primitive ectoderm surface [Term] id: PLANP:0000469 name: abnormal morphology of lumen gut surface def: "Any unspecified morphological anomaly of the gastrodermis surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of gastrodermis surface" EXACT [] is_a: PLANP:0000048 ! abnormal gastrodermis surface [Term] id: PLANP:0000470 name: abnormal morphology of basal epidermis surface def: "Any unspecified morphological anomaly of the basal surface of the epidermis, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of basal surface of the epidermis" EXACT [] is_a: PLANP:0000071 ! abnormal basal surface of the epidermis [Term] id: PLANP:0000475 name: abnormal morphology of apical epidermis surface def: "Any unspecified morphological anomaly of the apical surface of the epidermis, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of apical surface of the epidermis" EXACT [] is_a: PLANP:0000243 ! abnormal apical surface of the epidermis [Term] id: PLANP:0000480 name: abnormal morphology of pharyngeal pouch surface def: "Any unspecified morphological anomaly of the pharynx pouch epithelial surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of pharynx pouch epithelial surface" EXACT [] is_a: PLANP:0000296 ! abnormal pharynx pouch epithelial surface [Term] id: PLANP:0000481 name: abnormal morphology of embryonic gut cell surface def: "Any unspecified morphological anomaly of the embryonic gut cell surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of embryonic gut cell surface" EXACT [] is_a: PLANP:0000297 ! abnormal embryonic gut cell surface [Term] id: PLANP:0000482 name: abnormal morphology of primtive gut cell surface def: "Any unspecified morphological anomaly of the primtive gut cell surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of primtive gut cell surface" EXACT [] is_a: PLANP:0000327 ! abnormal primtive gut cell surface [Term] id: PLANP:0000484 name: abnormal morphology of pharynx lumen epithelial surface def: "Any unspecified morphological anomaly of the pharynx inner epithelium surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of pharynx inner epithelium surface" EXACT [] is_a: PLANP:0000348 ! abnormal pharynx lumen epithelial surface [Term] id: PLANP:0000486 name: abnormal morphology of temporary embryonic pharynx lumen epithelial surface def: "Any unspecified morphological anomaly of the embryonic pharynx lumen epithelial surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of embryonic pharynx lumen epithelial surface" EXACT [] is_a: PLANP:0000394 ! abnormal embryonic pharynx lumen epithelial surface [Term] id: PLANP:0000489 name: abnormal morphology of pharynx outer epithelial surface def: "Any unspecified morphological anomaly of the pharynx outer epithelium surface, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of pharynx outer epithelium surface" EXACT [] is_a: PLANP:0000465 ! abnormal pharynx outer epithelium surface [Term] id: PLANP:0000490 name: abormal shape of the ventral region of the animal def: "Any structural anomaly in the shape of the ventral region of the whole animal." [] synonym: "abnormally shaped ventral region of the whole animal" EXACT [] is_a: PLANP:0000548 ! abnormal ventral region [Term] id: PLANP:0000491 name: ventral curling def: "Any structural anomaly that causes ventral region of the whole animal to be curled shaped." [] synonym: "abnormal curled shape of ventral region of the whole animal" EXACT [] is_a: PLANP:0000490 ! abormal shape of the ventral region of the animal [Term] id: PLANP:0000492 name: pointy head def: "Any structural anomaly that causes head to be pointed shaped." [] synonym: "abnormal pointed shape of head" EXACT [] is_a: PLANP:0000499 ! abnormal shape of head [Term] id: PLANP:0000493 name: column-like head def: "Any structural anomaly that causes head to be columnar shaped." [] synonym: "abnormal columnar shape of head" EXACT [] is_a: PLANP:0000499 ! abnormal shape of head [Term] id: PLANP:0000494 name: skinny head def: "skinny or decreased width of the head." [] synonym: "skinny head" EXACT [] is_a: PLANP:0000501 ! abnormal size of head [Term] id: PLANP:0000496 name: pointy tail def: "Any structural anomaly that causes tail to be pointed shaped." [] synonym: "abnormal pointed shape of tail" EXACT [] is_a: PLANP:0000500 ! abnormal shape of tail [Term] id: PLANP:0000497 name: abnormal morphology of head def: "Any unspecified morphological anomaly of the head, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of head" EXACT [] is_a: PLANP:0000060 ! abnormal head [Term] id: PLANP:0000498 name: abnormal morphology of tail def: "Any unspecified morphological anomaly of the tail, such as, for example, abnormal shape or colour." [] synonym: "abnormal morphology of tail" EXACT [] is_a: PLANP:0000036 ! abnormal tail [Term] id: PLANP:0000499 name: abnormal shape of head def: "Any structural anomaly in the shape of the head." [] synonym: "abnormally shaped head" EXACT [] is_a: PLANP:0000497 ! abnormal morphology of head [Term] id: PLANP:0000500 name: abnormal shape of tail def: "Any structural anomaly in the shape of the tail." [] synonym: "abnormally shaped tail" EXACT [] is_a: PLANP:0000498 ! abnormal morphology of tail [Term] id: PLANP:0000501 name: abnormal size of head def: "A deviation from the normal size of the head." [] synonym: "abnormal size of the head" EXACT [] is_a: PLANP:0000497 ! abnormal morphology of head [Term] id: PLANP:0000502 name: abnormal size of tail def: "A deviation from the normal size of the tail." [] synonym: "abnormal size of the tail" EXACT [] is_a: PLANP:0000498 ! abnormal morphology of tail [Term] id: PLANP:0000503 name: skinny tail def: "skinny or decreased width of the tail." [] synonym: "skinny tail" EXACT [] is_a: PLANP:0000502 ! abnormal size of tail [Term] id: PLANP:0000504 name: star shaped lesion on the head def: "An abnormal head with a lesion that is star shaped." [] synonym: "star shaped lesion of the head" EXACT [] is_a: PLANP:0000060 ! abnormal head [Term] id: PLANP:0000505 name: circular shaped lesion on the head def: "An abnormal head with a lesion that is circular." [] synonym: "circular lesion of the head" EXACT [] is_a: PLANP:0000060 ! abnormal head [Term] id: PLANP:0000506 name: linear shaped lesion on the head def: "An abnormal head with a lesion that is linear." [] synonym: "linear lesion of the head" EXACT [] is_a: PLANP:0000060 ! abnormal head [Term] id: PLANP:0000507 name: star shaped lesion on the tail def: "An abnormal tail with a lesion that is star shaped." [] synonym: "star shaped lesion of the tail" EXACT [] is_a: PLANP:0000036 ! abnormal tail [Term] id: PLANP:0000508 name: circular shaped lesion on the tail def: "An abnormal tail with a lesion that is circular." [] synonym: "circular lesion of the tail" EXACT [] is_a: PLANP:0000036 ! abnormal tail [Term] id: PLANP:0000509 name: linear shaped lesion on the tail def: "An abnormal tail with a lesion that is linear." [] synonym: "linear lesion of the tail" EXACT [] is_a: PLANP:0000036 ! abnormal tail [Term] id: PLANP:0000510 name: eyes further apart than normae def: "Increased distance between eye and eye." [] synonym: "distance increased between eye and eye" EXACT [] is_a: PLANP:0000512 ! abnormal distance between eyes [Term] id: PLANP:0000511 name: eyes closer together than normal def: "Decreased distance between eye and eye." [] synonym: "distance decreased between eye and eye" EXACT [] is_a: PLANP:0000512 ! abnormal distance between eyes [Term] id: PLANP:0000512 name: abnormal distance between eyes def: "abnormal distance between eye and eye." [] synonym: "abnormal distance between eye and eye" EXACT [] synonym: "distance abnormal between eye and eye" EXACT [] is_a: PLANP:0000046 ! abnormal eye [Term] id: PLANP:0000513 name: lesion in the head def: "An abnormal head with one or more lesions." [] synonym: "head with lesion(s)" EXACT [] is_a: PLANP:0000497 ! abnormal morphology of head [Term] id: PLANP:0000514 name: lesion in the tail def: "An abnormal tail with one or more lesions." [] synonym: "tail with lesion(s)" EXACT [] is_a: PLANP:0000498 ! abnormal morphology of tail [Term] id: PLANP:0000515 name: loss of eyes def: "Absence of eye." [] synonym: "missing eye" EXACT [] is_a: PLANP:0000518 ! abnormal number of eyes [Term] id: PLANP:0000518 name: abnormal number of eyes def: "Any structural anomaly that causes there to be an abnormal number eye." [] synonym: "abnormal number of eyes" EXACT [] synonym: "altered number of eyes" EXACT [] is_a: PLANP:0000046 ! abnormal eye [Term] id: PLANP:0000519 name: decreased pigmentation of the eyes def: "Decreased or loss of pigmentation of eye." [] synonym: "eye hypopigmentation" EXACT [] synonym: "loss of pigment in the eye" EXACT [] is_a: PLANP:0000534 ! abnormal pigmentation of the eyes [Term] id: PLANP:0000520 name: loss of pigmentation in the eye def: "complete loss of pigmenation of the eye." [] synonym: "absence of pigment in the eye" EXACT [] synonym: "complete loss of pigmentation in the eye" EXACT [] is_a: PLANP:0000534 ! abnormal pigmentation of the eyes [Term] id: PLANP:0000521 name: short tail def: "Decreased length or shortening of the tail." [] synonym: "short tail" EXACT [] is_a: PLANP:0000502 ! abnormal size of tail [Term] id: PLANP:0000522 name: long head def: "longer, increased length of, head" [] synonym: "longer head" EXACT [] is_a: PLANP:0000501 ! abnormal size of head [Term] id: PLANP:0000523 name: long tail def: "longer, increased length of, tail" [] synonym: "longer tail" EXACT [] is_a: PLANP:0000502 ! abnormal size of tail [Term] id: PLANP:0000524 name: wide head def: "Increased width of head." [] synonym: "wider head" EXACT [] is_a: PLANP:0000501 ! abnormal size of head [Term] id: PLANP:0000525 name: wide tail def: "Increased width of tail." [] synonym: "wider tail" EXACT [] is_a: PLANP:0000502 ! abnormal size of tail [Term] id: PLANP:0000526 name: abnormal number of heads def: "Any structural anomaly that causes there to be an abnormal number head." [] synonym: "abnormal number of heads" EXACT [] synonym: "altered number of heads" EXACT [] is_a: PLANP:0000060 ! abnormal head [Term] id: PLANP:0000527 name: more heads def: "The presence of an increased number of head." [] synonym: "Extra head" EXACT [] is_a: PLANP:0000526 ! abnormal number of heads [Term] id: PLANP:0000529 name: loss of head def: "Absence of head." [] synonym: "missing head" EXACT [] is_a: PLANP:0000526 ! abnormal number of heads [Term] id: PLANP:0000530 name: abnormal number of tails def: "Any structural anomaly that causes there to be an abnormal number tail." [] synonym: "abnormal number of tails" EXACT [] synonym: "altered number of tails" EXACT [] is_a: PLANP:0000036 ! abnormal tail [Term] id: PLANP:0000531 name: more tails def: "The presence of an increased number of tail." [] synonym: "Extra tail" EXACT [] is_a: PLANP:0000530 ! abnormal number of tails [Term] id: PLANP:0000533 name: loss of tail def: "Absence of tail." [] synonym: "missing tail" EXACT [] is_a: PLANP:0000530 ! abnormal number of tails [Term] id: PLANP:0000534 name: abnormal pigmentation of the eyes def: "abnormal degree of pigmentation of the eye." [] synonym: "abnormal pigmentation of the eye" EXACT [] is_a: PLANP:0000046 ! abnormal eye [Term] id: PLANP:0000535 name: abnormal pigmentation of the epidermis def: "abnormal degree of pigmentation of the epidermis." [] synonym: "abnormal pigmentation of the epidermis" EXACT [] is_a: PLANP:0000427 ! abnormal epidermis [Term] id: PLANP:0000536 name: decreased pigmentation of the epidermis def: "Decreased or loss of pigmentation of epidermis." [] synonym: "epidermis hypopigmentation" EXACT [] synonym: "loss of pigment in the epidermis" EXACT [] is_a: PLANP:0000535 ! abnormal pigmentation of the epidermis [Term] id: PLANP:0000537 name: less eyes def: "The presence of a reduced number of eye." [] synonym: "Reduced number of eye" EXACT [] is_a: PLANP:0000518 ! abnormal number of eyes [Term] id: PLANP:0000538 name: less heads def: "The presence of a reduced number of head." [] synonym: "Reduced number of head" EXACT [] is_a: PLANP:0000526 ! abnormal number of heads [Term] id: PLANP:0000539 name: loss of pigmentation in the epidermis def: "complete loss of pigmenation of the epidermis." [] synonym: "absence of pigment in the epidermis" EXACT [] synonym: "complete loss of pigmentation in the epidermis" EXACT [] is_a: PLANP:0000535 ! abnormal pigmentation of the epidermis [Term] id: PLANP:0000540 name: less tails def: "The presence of a reduced number of tail." [] synonym: "Reduced number of tail" EXACT [] is_a: PLANP:0000530 ! abnormal number of tails [Term] id: PLANP:0000541 name: more eyes def: "The presence of an increased number of eye." [] synonym: "Extra eye" EXACT [] is_a: PLANP:0000518 ! abnormal number of eyes [Term] id: PLANP:0000542 name: abnormal whole organism def: "Abnormality of whole organism." [] synonym: "abnormality of whole organism" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000543 name: abnormal regeneration def: "Abnormality of regeneration." [] synonym: "abnormality of regeneration" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000544 name: abnormal Hyman vesicle def: "Abnormality of Hyman vesicle." [] synonym: "abnormality of Hyman vesicle" EXACT [] is_a: PLANP:0000682 ! abnormal intracellular granule [Term] id: PLANP:0000545 name: abnormal anterior region def: "Abnormality of anterior region of the whole animal." [] synonym: "abnormality of anterior region of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000546 name: abnormal dorsal region def: "Abnormality of dorsal region of the whole animal." [] synonym: "abnormality of dorsal region of the whole animal" EXACT [] is_a: PLANP:0000548 ! abnormal ventral region [Term] id: PLANP:0000547 name: abnormal posterior region def: "Abnormality of posterior compartment of the whole animal." [] synonym: "abnormality of posterior compartment of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000548 name: abnormal ventral region def: "Abnormality of ventral region of the whole animal." [] synonym: "abnormality of ventral region of the whole animal" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000549 name: abnormal heterochromatin def: "Abnormality of heterochromatin." [] synonym: "abnormality of heterochromatin" EXACT [] is_a: PLANP:0000119 ! abnormal chromatin [Term] id: PLANP:0000550 name: abnormal adenal rhabdite def: "Abnormality of adenal rhabdite." [] synonym: "abnormality of adenal rhabdite" EXACT [] is_a: PLANP:0000078 ! abnormal rhabdite [Term] id: PLANP:0000551 name: abnormal adherens junction def: "Abnormality of adherens junction." [] synonym: "abnormality of adherens junction" EXACT [] is_a: PLANP:0000094 ! abnormal cell-cell adhesion is_a: PLANP:0000420 ! abnormal cell junction [Term] id: PLANP:0000552 name: abnormal adhesive papilla def: "Abnormality of adhesive papilla." [] synonym: "abnormality of adhesive papilla" EXACT [] is_a: PLANP:0000111 ! abnormal releasing gland cell is_a: PLANP:0000287 ! abnormal viscid gland cell is_a: PLANP:0000366 ! abnormal cell projection [Term] id: PLANP:0000553 name: abnormal amputation def: "Abnormality of amputation." [] synonym: "abnormality of amputation" EXACT [] is_a: PLANP:0000576 ! abnormal cut [Term] id: PLANP:0000554 name: abnormal anterior gut branch def: "Abnormality of anterior gut branch." [] synonym: "abnormality of anterior gut branch" EXACT [] is_a: PLANP:0000666 ! abnormal gut branch [Term] id: PLANP:0000555 name: abnormal anterior tip def: "Abnormality of anterior tip." [] synonym: "abnormality of anterior tip" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000556 name: abnormal antrum def: "Abnormality of antrum." [] synonym: "abnormality of antrum" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000557 name: abnormal auricle def: "Abnormality of auricle." [] synonym: "abnormality of auricle" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000173 ! abnormal sensory system is_a: PLANP:0000365 ! abnormal peripheral nervous system [Term] id: PLANP:0000558 name: abnormal axon def: "Abnormality of axon." [] synonym: "abnormality of axon" EXACT [] is_a: PLANP:0000611 ! abnormal neurite [Term] id: PLANP:0000559 name: abnormal axoneme def: "Abnormality of axoneme." [] synonym: "abnormality of axoneme" EXACT [] is_a: PLANP:0000067 ! abnormal intracellular non-membrane-bounded organelle is_a: PLANP:0000574 ! abnormal cilium is_a: PLANP:0000590 ! abnormal flagellum [Term] id: PLANP:0000560 name: abnormal basal body def: "Abnormality of basal body." [] synonym: "abnormality of basal body" EXACT [] is_a: PLANP:0000067 ! abnormal intracellular non-membrane-bounded organelle is_a: PLANP:0000574 ! abnormal cilium is_a: PLANP:0000590 ! abnormal flagellum [Term] id: PLANP:0000561 name: abnormal brain visual center def: "Abnormality of brain visual center." [] synonym: "abnormality of brain visual center" EXACT [] is_a: PLANP:0000149 ! abnormal cephalic ganglia is_a: PLANP:0000198 ! abnormal visual system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000562 name: abnormal bulbar cavity def: "Abnormality of bulbar cavity." [] synonym: "abnormality of bulbar cavity" EXACT [] is_a: PLANP:0000136 ! abnormal seminal vesicle [Term] id: PLANP:0000563 name: abnormal Category 1 cell def: "Abnormality of Category 1 cell." [] synonym: "abnormality of Category 1 cell" EXACT [] is_a: PLANP:0000644 ! abnormal somatic cell is_a: PLANP:0000704 ! abnormal parenchymal cell [Term] id: PLANP:0000564 name: abnormal cell body def: "Abnormality of cell body." [] synonym: "abnormality of cell body" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000565 name: abnormal cephalic ganglia lobe def: "Abnormality of cephalic ganglia lobe." [] synonym: "abnormality of cephalic ganglia lobe" EXACT [] is_a: PLANP:0000149 ! abnormal cephalic ganglia is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000566 name: abnormal cephalic ganglia neuron def: "Abnormality of cephalic ganglia neuron." [] synonym: "abnormality of cephalic ganglia neuron" EXACT [] is_a: PLANP:0000011 ! abnormal central nervous system neuron is_a: PLANP:0000149 ! abnormal cephalic ganglia [Term] id: PLANP:0000567 name: abnormal chemical amputation def: "Abnormality of chemical amputation." [] synonym: "abnormality of chemical amputation" EXACT [] is_a: PLANP:0000657 ! abnormal wound [Term] id: PLANP:0000568 name: abnormal chemical pharynx amputation def: "Abnormality of chemical pharynx amputation." [] synonym: "abnormality of chemical pharynx amputation" EXACT [] is_a: PLANP:0000567 ! abnormal chemical amputation [Term] id: PLANP:0000569 name: abnormal chemosensory neuron def: "Abnormality of chemosensory neuron." [] synonym: "abnormality of chemosensory neuron" EXACT [] is_a: PLANP:0000173 ! abnormal sensory system is_a: PLANP:0000416 ! abnormal sensory neuron [Term] id: PLANP:0000570 name: abnormal chromatoid body def: "Abnormality of chromatoid body." [] synonym: "abnormality of chromatoid body" EXACT [] is_a: PLANP:0000192 ! abnormal non-membrane-bounded organelle [Term] id: PLANP:0000571 name: abnormal chromosome def: "Abnormality of chromosome." [] synonym: "abnormality of chromosome" EXACT [] is_a: PLANP:0000170 ! abnormal nuclear part is_a: PLANP:0000192 ! abnormal non-membrane-bounded organelle [Term] id: PLANP:0000572 name: abnormal chromosome arm def: "Abnormality of chromosome arm." [] synonym: "abnormality of chromosome arm" EXACT [] is_a: PLANP:0000571 ! abnormal chromosome [Term] id: PLANP:0000573 name: abnormal ciliated epithelium def: "Abnormality of ciliated epithelium." [] synonym: "abnormality of ciliated epithelium" EXACT [] is_a: PLANP:0000665 ! abnormal epithelium [Term] id: PLANP:0000574 name: abnormal cilium def: "Abnormality of cilium." [] synonym: "abnormality of cilium" EXACT [] is_a: PLANP:0000150 ! abnormal ciliated epithelial cell is_a: PLANP:0000366 ! abnormal cell projection [Term] id: PLANP:0000575 name: abnormal commissure def: "Abnormality of commissure." [] synonym: "abnormality of commissure" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000576 name: abnormal cut def: "Abnormality of cut." [] synonym: "abnormality of cut" EXACT [] is_a: PLANP:0000648 ! abnormal surgical wound [Term] id: PLANP:0000577 name: abnormal dendrite def: "Abnormality of dendrite." [] synonym: "abnormality of dendrite" EXACT [] is_a: PLANP:0000611 ! abnormal neurite [Term] id: PLANP:0000578 name: abnormal dorsal-ventral muscle cell def: "Abnormality of dorsal-ventral muscle cell." [] synonym: "abnormality of dorsal-ventral muscle cell" EXACT [] is_a: PLANP:0000091 ! abnormal muscle cell is_a: PLANP:0000256 ! abnormal parenchymal musculature [Term] id: PLANP:0000579 name: abnormal early female germ cell def: "Abnormality of early female germ cell." [] synonym: "abnormality of early female germ cell" EXACT [] is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000437 ! abnormal female germ cell [Term] id: PLANP:0000580 name: abnormal early male germ cell def: "Abnormality of early male germ cell." [] synonym: "abnormality of early male germ cell" EXACT [] is_a: PLANP:0000128 ! abnormal male germ cell is_a: PLANP:0000280 ! abnormal testis [Term] id: PLANP:0000581 name: abnormal embryonic gut def: "Abnormality of embryonic gut." [] synonym: "abnormality of embryonic gut" EXACT [] is_a: PLANP:0000090 ! abnormal embryonic digestive system is_a: PLANP:0000667 ! abnormal extraembryonic organ [Term] id: PLANP:0000582 name: abnormal epidermal cell def: "Abnormality of epidermal cell." [] synonym: "abnormality of epidermal cell" EXACT [] is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000583 name: abnormal epidermal rhabdite def: "Abnormality of epidermal rhabdite." [] synonym: "abnormality of epidermal rhabdite" EXACT [] is_a: PLANP:0000078 ! abnormal rhabdite [Term] id: PLANP:0000584 name: abnormal ER membrane def: "Abnormality of ER membrane." [] synonym: "abnormality of ER membrane" EXACT [] is_a: PLANP:0000206 ! abnormal bounding membrane of organelle is_a: PLANP:0000313 ! abnormal endoplasmic reticulum [Term] id: PLANP:0000585 name: abnormal eumelanin def: "Abnormality of eumelanin." [] synonym: "abnormality of eumelanin" EXACT [] is_a: PLANP:0000608 ! abnormal melanosome [Term] id: PLANP:0000586 name: abnormal excretory cell def: "Abnormality of excretory cell." [] synonym: "abnormality of excretory cell" EXACT [] is_a: PLANP:0000021 ! abnormal renal system is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000587 name: abnormal extracellular matrix def: "Abnormality of extracellular matrix." [] synonym: "abnormality of extracellular matrix" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000588 name: abnormal extracellular space def: "Abnormality of extracellular space." [] synonym: "abnormality of extracellular space" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000589 name: abnormal fission def: "Abnormality of fission." [] synonym: "abnormality of fission" EXACT [] is_a: PLANP:0000657 ! abnormal wound [Term] id: PLANP:0000590 name: abnormal flagellum def: "Abnormality of flagellum." [] synonym: "abnormality of flagellum" EXACT [] is_a: PLANP:0000349 ! abnormal sperm is_a: PLANP:0000366 ! abnormal cell projection [Term] id: PLANP:0000591 name: abnormal gap junction def: "Abnormality of gap junction." [] synonym: "abnormality of gap junction" EXACT [] is_a: PLANP:0000265 ! abnormal cell-cell junction [Term] id: PLANP:0000592 name: abnormal genital atrium def: "Abnormality of genital atrium." [] synonym: "abnormality of genital atrium" EXACT [] is_a: PLANP:0000353 ! abnormal reproductive system [Term] id: PLANP:0000593 name: abnormal germ cell cyst def: "Abnormality of germ cell cyst." [] synonym: "abnormality of germ cell cyst" EXACT [] is_a: PLANP:0000161 ! abnormal gonad is_a: PLANP:0000639 ! abnormal reproductive structure is_a: PLANP:0000681 ! abnormal syncytium [Term] id: PLANP:0000594 name: abnormal germline stem cell def: "Abnormality of germline stem cell." [] synonym: "abnormality of germline stem cell" EXACT [] is_a: PLANP:0000161 ! abnormal gonad is_a: PLANP:0000283 ! abnormal stem cell [Term] id: PLANP:0000595 name: abnormal glycogen granule def: "Abnormality of glycogen granule." [] synonym: "abnormality of glycogen granule" EXACT [] is_a: PLANP:0000682 ! abnormal intracellular granule [Term] id: PLANP:0000596 name: abnormal incision def: "Abnormality of incision." [] synonym: "abnormality of incision" EXACT [] is_a: PLANP:0000576 ! abnormal cut [Term] id: PLANP:0000597 name: abnormal pharynx inner epidermal cell def: "Abnormality of pharynx inner epidermal cell." [] synonym: "abnormality of pharynx inner epidermal cell" EXACT [] is_a: PLANP:0000058 ! abnormal pharynx epithelium is_a: PLANP:0000150 ! abnormal ciliated epithelial cell is_a: PLANP:0000582 ! abnormal epidermal cell [Term] id: PLANP:0000598 name: abnormal inner zone of gland cells def: "Abnormality of inner zone of gland cells." [] synonym: "abnormality of inner zone of gland cells" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000599 name: abnormal intercellular junction def: "Abnormality of intercellular junction." [] synonym: "abnormality of intercellular junction" EXACT [] is_a: PLANP:0000265 ! abnormal cell-cell junction [Term] id: PLANP:0000600 name: abnormal linear amputation def: "Abnormality of linear amputation." [] synonym: "abnormality of linear amputation" EXACT [] is_a: PLANP:0000553 ! abnormal amputation [Term] id: PLANP:0000601 name: abnormal linear incision def: "Abnormality of linear incision." [] synonym: "abnormality of linear incision" EXACT [] is_a: PLANP:0000596 ! abnormal incision [Term] id: PLANP:0000602 name: abnormal lipid droplet def: "Abnormality of lipid droplet." [] synonym: "abnormality of lipid droplet" EXACT [] is_a: PLANP:0000067 ! abnormal intracellular non-membrane-bounded organelle [Term] id: PLANP:0000603 name: abnormal lumen def: "Abnormality of lumen." [] synonym: "abnormality of lumen" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000604 name: abnormal marginal adhesive zone def: "Abnormality of marginal adhesive zone." [] synonym: "abnormality of marginal adhesive zone" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000605 name: abnormal mechanosensory neuron def: "Abnormality of mechanosensory neuron." [] synonym: "abnormality of mechanosensory neuron" EXACT [] is_a: PLANP:0000173 ! abnormal sensory system is_a: PLANP:0000416 ! abnormal sensory neuron [Term] id: PLANP:0000606 name: abnormal medial muscle cell def: "Abnormality of medial muscle cell." [] synonym: "abnormality of medial muscle cell" EXACT [] is_a: PLANP:0000091 ! abnormal muscle cell is_a: PLANP:0000256 ! abnormal parenchymal musculature [Term] id: PLANP:0000607 name: abnormal meiotic germ cell def: "Abnormality of meiotic germ cell." [] synonym: "abnormality of meiotic germ cell" EXACT [] is_a: PLANP:0000288 ! abnormal germ cell [Term] id: PLANP:0000608 name: abnormal melanosome def: "Abnormality of melanosome." [] synonym: "abnormality of melanosome" EXACT [] is_a: PLANP:0000044 ! abnormal pigment cup cell is_a: PLANP:0000398 ! abnormal intracellular membrane-bounded organelle [Term] id: PLANP:0000609 name: abnormal mucus def: "Abnormality of mucus." [] synonym: "abnormality of mucus" EXACT [] is_a: PLANP:0000384 ! abnormal secretory system [Term] id: PLANP:0000610 name: abnormal nephridiopore def: "Abnormality of nephridiopore." [] synonym: "abnormality of nephridiopore" EXACT [] is_a: PLANP:0000230 ! abnormal flame cell is_a: PLANP:0000628 ! abnormal pore [Term] id: PLANP:0000611 name: abnormal neurite def: "Abnormality of neurite." [] synonym: "abnormality of neurite" EXACT [] is_a: PLANP:0000366 ! abnormal cell projection is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000612 name: abnormal neuropeptidergic neuron def: "Abnormality of neuropeptidergic neuron." [] synonym: "abnormality of neuropeptidergic neuron" EXACT [] is_a: PLANP:0000238 ! abnormal central nervous system is_a: PLANP:0000365 ! abnormal peripheral nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000613 name: abnormal non-ciliated epidermis def: "Abnormality of non-ciliated epidermis." [] synonym: "abnormality of non-ciliated epidermis" EXACT [] is_a: PLANP:0000427 ! abnormal epidermis [Term] id: PLANP:0000614 name: abnormal nuclear envelope def: "Abnormality of nuclear envelope." [] synonym: "abnormality of nuclear envelope" EXACT [] is_a: PLANP:0000229 ! abnormal membrane [Term] id: PLANP:0000615 name: abnormal nuclear inner membrane def: "Abnormality of nuclear inner membrane." [] synonym: "abnormality of nuclear inner membrane" EXACT [] is_a: PLANP:0000388 ! abnormal membrane part is_a: PLANP:0000614 ! abnormal nuclear envelope [Term] id: PLANP:0000616 name: abnormal nuclear lumen def: "Abnormality of nuclear lumen." [] synonym: "abnormality of nuclear lumen" EXACT [] is_a: PLANP:0000170 ! abnormal nuclear part [Term] id: PLANP:0000617 name: abnormal nuclear outer membrane def: "Abnormality of nuclear outer membrane." [] synonym: "abnormality of nuclear outer membrane" EXACT [] is_a: PLANP:0000388 ! abnormal membrane part is_a: PLANP:0000614 ! abnormal nuclear envelope [Term] id: PLANP:0000618 name: abnormal nuclear periphery def: "Abnormality of nuclear periphery." [] synonym: "abnormality of nuclear periphery" EXACT [] is_a: PLANP:0000170 ! abnormal nuclear part [Term] id: PLANP:0000619 name: abnormal ommochrome pigment cell def: "Abnormality of ommochrome pigment cell." [] synonym: "abnormality of ommochrome pigment cell" EXACT [] is_a: PLANP:0000624 ! abnormal pigment cell [Term] id: PLANP:0000620 name: abnormal optic nerve def: "Abnormality of optic nerve." [] synonym: "abnormality of optic nerve" EXACT [] is_a: PLANP:0000198 ! abnormal visual system is_a: PLANP:0000456 ! abnormal nerve [Term] id: PLANP:0000621 name: abnormal pharynx outer epidermal cell def: "Abnormality of pharynx outer epidermal cell." [] synonym: "abnormality of pharynx outer epidermal cell" EXACT [] is_a: PLANP:0000058 ! abnormal pharynx epithelium is_a: PLANP:0000150 ! abnormal ciliated epithelial cell is_a: PLANP:0000582 ! abnormal epidermal cell [Term] id: PLANP:0000622 name: abnormal phagocytic cell def: "Abnormality of phagocytic cell." [] synonym: "abnormality of phagocytic cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000623 name: abnormal pharynx tip def: "Abnormality of pharynx tip." [] synonym: "abnormality of pharynx tip" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000624 name: abnormal pigment cell def: "Abnormality of pigment cell." [] synonym: "abnormality of pigment cell" EXACT [] is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000625 name: abnormal pigment granule def: "Abnormality of pigment granule." [] synonym: "abnormality of pigment granule" EXACT [] is_a: PLANP:0000131 ! abnormal membrane-bounded organelle is_a: PLANP:0000624 ! abnormal pigment cell [Term] id: PLANP:0000626 name: abnormal plug amputation def: "Abnormality of plug amputation." [] synonym: "abnormality of plug amputation" EXACT [] is_a: PLANP:0000553 ! abnormal amputation [Term] id: PLANP:0000627 name: abnormal point incision def: "Abnormality of point incision." [] synonym: "abnormality of point incision" EXACT [] is_a: PLANP:0000596 ! abnormal incision [Term] id: PLANP:0000628 name: abnormal pore def: "Abnormality of pore." [] synonym: "abnormality of pore" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000629 name: abnormal post-meiotic germ cell def: "Abnormality of post-meiotic germ cell." [] synonym: "abnormality of post-meiotic germ cell" EXACT [] is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000280 ! abnormal testis is_a: PLANP:0000288 ! abnormal germ cell [Term] id: PLANP:0000630 name: abnormal postsynaptic cell def: "Abnormality of postsynaptic cell." [] synonym: "abnormality of postsynaptic cell" EXACT [] is_a: PLANP:0000199 ! abnormal nervous system is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000631 name: abnormal premeiotic germ cell def: "Abnormality of premeiotic germ cell." [] synonym: "abnormality of premeiotic germ cell" EXACT [] is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000280 ! abnormal testis is_a: PLANP:0000288 ! abnormal germ cell [Term] id: PLANP:0000632 name: abnormal presynaptic cell def: "Abnormality of presynaptic cell." [] synonym: "abnormality of presynaptic cell" EXACT [] is_a: PLANP:0000199 ! abnormal nervous system is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000633 name: abnormal presynaptic terminal def: "Abnormality of presynaptic terminal." [] synonym: "abnormality of presynaptic terminal" EXACT [] is_a: PLANP:0000558 ! abnormal axon is_a: PLANP:0000632 ! abnormal presynaptic cell [Term] id: PLANP:0000634 name: abnormal presynaptic vesicle def: "Abnormality of presynaptic vesicle." [] synonym: "abnormality of presynaptic vesicle" EXACT [] is_a: PLANP:0000131 ! abnormal membrane-bounded organelle is_a: PLANP:0000632 ! abnormal presynaptic cell [Term] id: PLANP:0000635 name: abnormal primary gut branch def: "Abnormality of primary gut branch." [] synonym: "abnormality of primary gut branch" EXACT [] is_a: PLANP:0000666 ! abnormal gut branch [Term] id: PLANP:0000636 name: abnormal primitive gut def: "Abnormality of primitive gut." [] synonym: "abnormality of primitive gut" EXACT [] is_a: PLANP:0000090 ! abnormal embryonic digestive system is_a: PLANP:0000667 ! abnormal extraembryonic organ [Term] id: PLANP:0000637 name: abnormal quarternary gut branch def: "Abnormality of quarternary gut branch." [] synonym: "abnormality of quarternary gut branch" EXACT [] is_a: PLANP:0000666 ! abnormal gut branch [Term] id: PLANP:0000638 name: abnormal reproductive organ def: "Abnormality of reproductive organ." [] synonym: "abnormality of reproductive organ" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000353 ! abnormal reproductive system [Term] id: PLANP:0000639 name: abnormal reproductive structure def: "Abnormality of reproductive structure." [] synonym: "abnormality of reproductive structure" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000640 name: abnormal rhabdome def: "Abnormality of rhabdome." [] synonym: "abnormality of rhabdome" EXACT [] is_a: PLANP:0000046 ! abnormal eye is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000641 name: abnormal rhabdomere def: "Abnormality of rhabdomere." [] synonym: "abnormality of rhabdomere" EXACT [] is_a: PLANP:0000159 ! abnormal photoreceptor neuron is_a: PLANP:0000366 ! abnormal cell projection [Term] id: PLANP:0000642 name: abnormal secretory duct def: "Abnormality of secretory duct." [] synonym: "abnormality of secretory duct" EXACT [] is_a: PLANP:0000372 ! abnormal tissue is_a: PLANP:0000384 ! abnormal secretory system [Term] id: PLANP:0000643 name: abnormal secretory granule def: "Abnormality of secretory granule." [] synonym: "abnormality of secretory granule" EXACT [] is_a: PLANP:0000131 ! abnormal membrane-bounded organelle is_a: PLANP:0000331 ! abnormal secretory cell [Term] id: PLANP:0000644 name: abnormal somatic cell def: "Abnormality of somatic cell." [] synonym: "abnormality of somatic cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000645 name: abnormal somatic gonadal cell def: "Abnormality of somatic gonadal cell." [] synonym: "abnormality of somatic gonadal cell" EXACT [] is_a: PLANP:0000161 ! abnormal gonad is_a: PLANP:0000268 ! abnormal terminally differentiated cell [Term] id: PLANP:0000646 name: abnormal specialized neoblast def: "Abnormality of specialized neoblast." [] synonym: "abnormality of specialized neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000647 name: abnormal stalk def: "Abnormality of stalk." [] synonym: "abnormality of stalk" EXACT [] is_a: PLANP:0000329 ! abnormal egg capsule [Term] id: PLANP:0000648 name: abnormal surgical wound def: "Abnormality of surgical wound." [] synonym: "abnormality of surgical wound" EXACT [] is_a: PLANP:0000657 ! abnormal wound [Term] id: PLANP:0000649 name: abnormal synapse def: "Abnormality of synapse." [] synonym: "abnormality of synapse" EXACT [] is_a: PLANP:0000265 ! abnormal cell-cell junction is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000650 name: abnormal synaptic cleft def: "Abnormality of synaptic cleft." [] synonym: "abnormality of synaptic cleft" EXACT [] is_a: PLANP:0000183 ! abnormal electrically responsive cell is_a: PLANP:0000452 ! abnormal neuron is_a: PLANP:0000588 ! abnormal extracellular space [Term] id: PLANP:0000651 name: abnormal synaptic vesicle def: "Abnormality of synaptic vesicle." [] synonym: "abnormality of synaptic vesicle" EXACT [] is_a: PLANP:0000131 ! abnormal membrane-bounded organelle is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000652 name: abnormal synaptonemal complex def: "Abnormality of synaptonemal complex." [] synonym: "abnormality of synaptonemal complex" EXACT [] is_a: PLANP:0000670 ! abnormal chromosomal:structural:element [Term] id: PLANP:0000653 name: abnormal tail tip def: "Abnormality of tail tip." [] synonym: "abnormality of tail tip" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000654 name: abnormal telomere def: "Abnormality of telomere." [] synonym: "abnormality of telomere" EXACT [] is_a: PLANP:0000572 ! abnormal chromosome arm is_a: PLANP:0000668 ! abnormal chromosome:part [Term] id: PLANP:0000655 name: abnormal tight junction def: "Abnormality of septate junction." [] synonym: "abnormality of septate junction" EXACT [] is_a: PLANP:0000265 ! abnormal cell-cell junction is_a: PLANP:0000665 ! abnormal epithelium [Term] id: PLANP:0000656 name: abnormal wedge amputation def: "Abnormality of wedge amputation." [] synonym: "abnormality of wedge amputation" EXACT [] is_a: PLANP:0000553 ! abnormal amputation [Term] id: PLANP:0000657 name: abnormal wound def: "Abnormality of wound." [] synonym: "abnormality of wound" EXACT [] is_a: PLANP:0000669 ! abnormal perturbation [Term] id: PLANP:0000658 name: abnormal X1 cell def: "Abnormality of X1 cell." [] synonym: "abnormality of X1 cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell is_a: PLANP:0000683 ! abnormal FACS sorted cell population [Term] id: PLANP:0000659 name: abnormal X1(FS) cell def: "Abnormality of X1(FS) cell." [] synonym: "abnormality of X1(FS) cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell is_a: PLANP:0000683 ! abnormal FACS sorted cell population [Term] id: PLANP:0000660 name: abnormal X2 cell def: "Abnormality of X2 cell." [] synonym: "abnormality of X2 cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell is_a: PLANP:0000683 ! abnormal FACS sorted cell population [Term] id: PLANP:0000661 name: abnormal Xins cell def: "Abnormality of Xins cell." [] synonym: "abnormality of Xins cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell is_a: PLANP:0000683 ! abnormal FACS sorted cell population [Term] id: PLANP:0000662 name: abnormal post-pharyngeal region def: "Abnormality of post-pharyngeal region." [] synonym: "abnormality of post-pharyngeal region" EXACT [] is_a: PLANP:0000261 ! abnormal anatomical region [Term] id: PLANP:0000663 name: abnormal post-blastema region def: "Abnormality of post-blastema region." [] synonym: "abnormality of post-blastema region" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000664 name: abnormal fission fragment def: "Abnormality of fission fragment." [] synonym: "abnormality of fission fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000665 name: abnormal epithelium def: "Abnormality of epithelium." [] synonym: "abnormality of epithelium" EXACT [] is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000666 name: abnormal gut branch def: "Abnormality of gut branch." [] synonym: "abnormality of gut branch" EXACT [] is_a: PLANP:0000175 ! abnormal gut is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000667 name: abnormal extraembryonic organ def: "Abnormality of extraembryonic organ." [] synonym: "abnormality of extraembryonic organ" EXACT [] is_a: PLANP:0000043 ! abnormal organ is_a: PLANP:0000289 ! abnormal embryo [Term] id: PLANP:0000668 name: abnormal chromosome:part def: "Abnormality of chromosome_part." [] synonym: "abnormality of chromosome_part" EXACT [] is_a: PLANP:0000571 ! abnormal chromosome [Term] id: PLANP:0000669 name: abnormal perturbation def: "Abnormality of perturbation." [] synonym: "abnormality of perturbation" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000670 name: abnormal chromosomal:structural:element def: "Abnormality of chromosomal_structural_element." [] synonym: "abnormality of chromosomal_structural_element" EXACT [] is_a: PLANP:0000668 ! abnormal chromosome:part [Term] id: PLANP:0000671 name: abnormal thick fragment def: "Abnormality of thick fragment." [] synonym: "abnormality of thick fragment" EXACT [] is_a: PLANP:0000786 ! abnormal longitudinal fragment [Term] id: PLANP:0000672 name: abnormal thin fragment def: "Abnormality of thin fragment." [] synonym: "abnormality of thin fragment" EXACT [] is_a: PLANP:0000786 ! abnormal longitudinal fragment [Term] id: PLANP:0000673 name: abnormal fragment def: "Abnormality of fragment." [] synonym: "abnormality of fragment" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000674 name: abnormal longitudinal region def: "Abnormality of longitudinal region." [] synonym: "abnormality of longitudinal region" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000675 name: abnormal chemical wound def: "Abnormality of chemical wound." [] synonym: "abnormality of chemical wound" EXACT [] is_a: PLANP:0000657 ! abnormal wound [Term] id: PLANP:0000676 name: abnormal plug wound def: "Abnormality of plug wound." [] synonym: "abnormality of plug wound" EXACT [] is_a: PLANP:0000657 ! abnormal wound [Term] id: PLANP:0000677 name: abnormal wedge wound def: "Abnormality of wedge wound." [] synonym: "abnormality of wedge wound" EXACT [] is_a: PLANP:0000657 ! abnormal wound [Term] id: PLANP:0000678 name: abnormal regenerating fragment def: "Abnormality of regenerating fragment." [] synonym: "abnormality of regenerating fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000679 name: abnormal sagittal orientation def: "Abnormality of sagittal orientation." [] synonym: "abnormality of sagittal orientation" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000680 name: abnormal parasagittal orientation def: "Abnormality of parasagittal orientation." [] synonym: "abnormality of parasagittal orientation" EXACT [] is_a: PLANP:0000679 ! abnormal sagittal orientation [Term] id: PLANP:0000681 name: abnormal syncytium def: "Abnormality of syncytium." [] synonym: "abnormality of syncytium" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000682 name: abnormal intracellular granule def: "Abnormality of intracellular granule." [] synonym: "abnormality of intracellular granule" EXACT [] is_a: PLANP:0000067 ! abnormal intracellular non-membrane-bounded organelle [Term] id: PLANP:0000683 name: abnormal FACS sorted cell population def: "Abnormality of FACS sorted cell population." [] synonym: "abnormality of FACS sorted cell population" EXACT [] is_a: PLANP:0000684 ! abnormal derived cell population [Term] id: PLANP:0000684 name: abnormal derived cell population def: "Abnormality of derived cell population." [] synonym: "abnormality of derived cell population" EXACT [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000685 name: abnormal pharynx pouch epithelium def: "Abnormality of pharynx pouch epithelium." [] synonym: "abnormality of pharynx pouch epithelium" EXACT [] is_a: PLANP:0000185 ! abnormal pharynx pouch is_a: PLANP:0000665 ! abnormal epithelium [Term] id: PLANP:0000686 name: abnormal sperm duct epithelial surface def: "Abnormality of sperm duct epithelial surface." [] synonym: "abnormality of sperm duct epithelial surface" EXACT [] is_a: PLANP:0000105 ! abnormal sperm duct epithelium [Term] id: PLANP:0000687 name: abnormal parenchyma def: "Abnormality of parenchyma." [] synonym: "abnormality of parenchyma" EXACT [] is_a: PLANP:0000372 ! abnormal tissue [Term] id: PLANP:0000688 name: abnormal testis cell def: "Abnormality of testis cell." [] synonym: "abnormality of testis cell" EXACT [] is_a: PLANP:0000280 ! abnormal testis is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000689 name: abnormal ventral epidermis cell def: "Abnormality of ventral epidermis cell." [] synonym: "abnormality of ventral epidermis cell" EXACT [] is_a: PLANP:0000052 ! abnormal ventral epidermis is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000690 name: abnormal visual system cell def: "Abnormality of visual system cell." [] synonym: "abnormality of visual system cell" EXACT [] is_a: PLANP:0000198 ! abnormal visual system is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000691 name: abnormal eye cell def: "Abnormality of eye cell." [] synonym: "abnormality of eye cell" EXACT [] is_a: PLANP:0000046 ! abnormal eye is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000692 name: abnormal enteric muscle cell def: "Abnormality of enteric muscle cell." [] synonym: "abnormality of enteric muscle cell" EXACT [] is_a: PLANP:0000342 ! abnormal enteric musculature is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000693 name: abnormal dorsal epidermis cell def: "Abnormality of dorsal epidermis cell." [] synonym: "abnormality of dorsal epidermis cell" EXACT [] is_a: PLANP:0000135 ! abnormal dorsal epidermis is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000694 name: abnormal adhesion gland cell def: "Abnormality of adhesion gland cell." [] synonym: "abnormality of adhesion gland cell" EXACT [] is_a: PLANP:0000140 ! abnormal adhesion gland is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000695 name: abnormal body wall muscle cell def: "Abnormality of body wall muscle cell." [] synonym: "abnormality of body wall muscle cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell is_a: PLANP:0000392 ! abnormal body wall musculature [Term] id: PLANP:0000696 name: abnormal gastrodermal cell def: "Abnormality of gastrodermal cell." [] synonym: "abnormality of gastrodermal cell" EXACT [] is_a: PLANP:0000209 ! abnormal gastrodermis is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000697 name: abnormal anterior pole cell def: "Abnormality of anterior pole cell." [] synonym: "abnormality of anterior pole cell" EXACT [] is_a: PLANP:0000277 ! abnormal anterior pole is_a: PLANP:0000363 ! abnormal cell [Term] id: PLANP:0000698 name: abnormal pharynx neuron def: "Abnormality of pharynx neuron." [] synonym: "abnormality of pharynx neuron" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000452 ! abnormal neuron [Term] id: PLANP:0000699 name: abnormal pharynx epithelial cell def: "Abnormality of pharynx epithelial cell." [] synonym: "abnormality of pharynx epithelial cell" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000700 name: abnormal pharynx muscle cell def: "Abnormality of pharynx muscle cell." [] synonym: "abnormality of pharynx muscle cell" EXACT [] is_a: PLANP:0000051 ! abnormal definitive pharynx is_a: PLANP:0000091 ! abnormal muscle cell [Term] id: PLANP:0000701 name: abnormal pharynx pouch epithelial cell def: "Abnormality of pharynx pouch epithelial cell." [] synonym: "abnormality of pharynx pouch epithelial cell" EXACT [] is_a: PLANP:0000185 ! abnormal pharynx pouch is_a: PLANP:0000310 ! abnormal epithelial cell [Term] id: PLANP:0000702 name: abnormal melanin pigment granule def: "Abnormality of melanin pigment granule." [] synonym: "abnormality of melanin pigment granule" EXACT [] is_a: PLANP:0000585 ! abnormal eumelanin is_a: PLANP:0000625 ! abnormal pigment granule [Term] id: PLANP:0000703 name: abnormal ommochrome pigment granule def: "Abnormality of ommochrome pigment granule." [] synonym: "abnormality of ommochrome pigment granule" EXACT [] is_a: PLANP:0000619 ! abnormal ommochrome pigment cell is_a: PLANP:0000625 ! abnormal pigment granule [Term] id: PLANP:0000704 name: abnormal parenchymal cell def: "Abnormality of parenchymal cell." [] synonym: "abnormality of parenchymal cell" EXACT [] is_a: PLANP:0000363 ! abnormal cell is_a: PLANP:0000687 ! abnormal parenchyma [Term] id: PLANP:0000705 name: abnormal G1 phase neoblast def: "Abnormality of G1 phase neoblast." [] synonym: "abnormality of G1 phase neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000706 name: abnormal S phase neoblast def: "Abnormality of S phase neoblast." [] synonym: "abnormality of S phase neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000707 name: abnormal G2 phase neoblast def: "Abnormality of G2 phase neoblast." [] synonym: "abnormality of G2 phase neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000708 name: abnormal prophase neoblast def: "Abnormality of prophase neoblast." [] synonym: "abnormality of prophase neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000709 name: abnormal metaphase neoblast def: "Abnormality of metaphase neoblast." [] synonym: "abnormality of metaphase neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000710 name: abnormal anaphase neoblast def: "Abnormality of anaphase neoblast." [] synonym: "abnormality of anaphase neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000711 name: abnormal telophase neoblast def: "Abnormality of telophase neoblast." [] synonym: "abnormality of telophase neoblast" EXACT [] is_a: PLANP:0000029 ! abnormal neoblast [Term] id: PLANP:0000712 name: abnormal G1 phase spermatogonial stem cell def: "Abnormality of G1 phase spermatogonial stem cell." [] synonym: "abnormality of G1 phase spermatogonial stem cell" EXACT [] is_a: PLANP:0000250 ! abnormal spermatogonial stem cell [Term] id: PLANP:0000713 name: abnormal S phase spermatogonial stem cell def: "Abnormality of S phase spermatogonial stem cell." [] synonym: "abnormality of S phase spermatogonial stem cell" EXACT [] is_a: PLANP:0000250 ! abnormal spermatogonial stem cell [Term] id: PLANP:0000714 name: abnormal G2 phase spermatogonial stem cell def: "Abnormality of G2 phase spermatogonial stem cell." [] synonym: "abnormality of G2 phase spermatogonial stem cell" EXACT [] is_a: PLANP:0000250 ! abnormal spermatogonial stem cell [Term] id: PLANP:0000715 name: abnormal prophase spermatogonial stem cell def: "Abnormality of prophase spermatogonial stem cell." [] synonym: "abnormality of prophase spermatogonial stem cell" EXACT [] is_a: PLANP:0000250 ! abnormal spermatogonial stem cell [Term] id: PLANP:0000716 name: abnormal metaphase spermatogonial stem cell def: "Abnormality of metaphase spermatogonial stem cell." [] synonym: "abnormality of metaphase spermatogonial stem cell" EXACT [] is_a: PLANP:0000250 ! abnormal spermatogonial stem cell [Term] id: PLANP:0000717 name: abnormal anaphase spermatogonial stem cell def: "Abnormality of anaphase spermatogonial stem cell." [] synonym: "abnormality of anaphase spermatogonial stem cell" EXACT [] is_a: PLANP:0000250 ! abnormal spermatogonial stem cell [Term] id: PLANP:0000718 name: abnormal telophase spermatogonial stem cell def: "Abnormality of telophase spermatogonial stem cell." [] synonym: "abnormality of telophase spermatogonial stem cell" EXACT [] is_a: PLANP:0000250 ! abnormal spermatogonial stem cell [Term] id: PLANP:0000719 name: abnormal G1 phase oogonial stem cell def: "Abnormality of G1 phase oogonial stem cell." [] synonym: "abnormality of G1 phase oogonial stem cell" EXACT [] is_a: PLANP:0000399 ! abnormal oogonial stem cell [Term] id: PLANP:0000720 name: abnormal S phase oogonial stem cell def: "Abnormality of S phase oogonial stem cell." [] synonym: "abnormality of S phase oogonial stem cell" EXACT [] is_a: PLANP:0000399 ! abnormal oogonial stem cell [Term] id: PLANP:0000721 name: abnormal G2 phase oogonial stem cell def: "Abnormality of G2 phase oogonial stem cell." [] synonym: "abnormality of G2 phase oogonial stem cell" EXACT [] is_a: PLANP:0000399 ! abnormal oogonial stem cell [Term] id: PLANP:0000722 name: abnormal prophase oogonial stem cell def: "Abnormality of prophase oogonial stem cell." [] synonym: "abnormality of prophase oogonial stem cell" EXACT [] is_a: PLANP:0000399 ! abnormal oogonial stem cell [Term] id: PLANP:0000723 name: abnormal metaphase oogonial stem cell def: "Abnormality of metaphase oogonial stem cell." [] synonym: "abnormality of metaphase oogonial stem cell" EXACT [] is_a: PLANP:0000399 ! abnormal oogonial stem cell [Term] id: PLANP:0000724 name: abnormal anaphase oogonial stem cell def: "Abnormality of anaphase oogonial stem cell." [] synonym: "abnormality of anaphase oogonial stem cell" EXACT [] is_a: PLANP:0000399 ! abnormal oogonial stem cell [Term] id: PLANP:0000725 name: abnormal telophase oogonial stem cell def: "Abnormality of telophase oogonial stem cell." [] synonym: "abnormality of telophase oogonial stem cell" EXACT [] is_a: PLANP:0000399 ! abnormal oogonial stem cell [Term] id: PLANP:0000726 name: abnormal G1 phase spermatogonium def: "Abnormality of G1 phase spermatogonium." [] synonym: "abnormality of G1 phase spermatogonium" EXACT [] is_a: PLANP:0000132 ! abnormal spermatogonium [Term] id: PLANP:0000727 name: abnormal S phase spermatogonium def: "Abnormality of S phase spermatogonium." [] synonym: "abnormality of S phase spermatogonium" EXACT [] is_a: PLANP:0000132 ! abnormal spermatogonium [Term] id: PLANP:0000728 name: abnormal G2 phase spermatogonium def: "Abnormality of G2 phase spermatogonium." [] synonym: "abnormality of G2 phase spermatogonium" EXACT [] is_a: PLANP:0000132 ! abnormal spermatogonium [Term] id: PLANP:0000729 name: abnormal prophase spermatogonium def: "Abnormality of prophase spermatogonium." [] synonym: "abnormality of prophase spermatogonium" EXACT [] is_a: PLANP:0000132 ! abnormal spermatogonium [Term] id: PLANP:0000730 name: abnormal metaphase spermatogonia def: "Abnormality of metaphase spermatogonia." [] synonym: "abnormality of metaphase spermatogonia" EXACT [] is_a: PLANP:0000132 ! abnormal spermatogonium [Term] id: PLANP:0000731 name: abnormal anaphase spermatogonia def: "Abnormality of anaphase spermatogonia." [] synonym: "abnormality of anaphase spermatogonia" EXACT [] is_a: PLANP:0000132 ! abnormal spermatogonium [Term] id: PLANP:0000732 name: abnormal telophase spermatogonium def: "Abnormality of telophase spermatogonium." [] synonym: "abnormality of telophase spermatogonium" EXACT [] is_a: PLANP:0000132 ! abnormal spermatogonium [Term] id: PLANP:0000733 name: abnormal G1 phase oogonial cell def: "Abnormality of G1 phase oogonial cell." [] synonym: "abnormality of G1 phase oogonial cell" EXACT [] is_a: PLANP:0000216 ! abnormal oogonial cell [Term] id: PLANP:0000734 name: abnormal S phase oogonial cell def: "Abnormality of S phase oogonial cell." [] synonym: "abnormality of S phase oogonial cell" EXACT [] is_a: PLANP:0000216 ! abnormal oogonial cell [Term] id: PLANP:0000735 name: abnormal G2 phase oogonial cell def: "Abnormality of G2 phase oogonial cell." [] synonym: "abnormality of G2 phase oogonial cell" EXACT [] is_a: PLANP:0000216 ! abnormal oogonial cell [Term] id: PLANP:0000736 name: abnormal prophase oogonial cell def: "Abnormality of prophase oogonial cell." [] synonym: "abnormality of prophase oogonial cell" EXACT [] is_a: PLANP:0000216 ! abnormal oogonial cell [Term] id: PLANP:0000737 name: abnormal metaphase oogonial cell def: "Abnormality of metaphase oogonial cell." [] synonym: "abnormality of metaphase oogonial cell" EXACT [] is_a: PLANP:0000216 ! abnormal oogonial cell [Term] id: PLANP:0000738 name: abnormal anaphase oogonial cell def: "Abnormality of anaphase oogonial cell." [] synonym: "abnormality of anaphase oogonial cell" EXACT [] is_a: PLANP:0000216 ! abnormal oogonial cell [Term] id: PLANP:0000739 name: abnormal telophase oogonial cell def: "Abnormality of telophase oogonial cell." [] synonym: "abnormality of telophase oogonial cell" EXACT [] is_a: PLANP:0000216 ! abnormal oogonial cell [Term] id: PLANP:0000740 name: abnormal G1 phase germ cell cyst def: "Abnormality of G1 phase germ cell cyst." [] synonym: "abnormality of G1 phase germ cell cyst" EXACT [] is_a: PLANP:0000593 ! abnormal germ cell cyst [Term] id: PLANP:0000741 name: abnormal S phase germ cell cyst def: "Abnormality of S phase germ cell cyst." [] synonym: "abnormality of S phase germ cell cyst" EXACT [] is_a: PLANP:0000593 ! abnormal germ cell cyst [Term] id: PLANP:0000742 name: abnormal G2 phase germ cell cyst def: "Abnormality of G2 phase germ cell cyst." [] synonym: "abnormality of G2 phase germ cell cyst" EXACT [] is_a: PLANP:0000593 ! abnormal germ cell cyst [Term] id: PLANP:0000743 name: abnormal prophase germ cell cyst def: "Abnormality of prophase germ cell cyst." [] synonym: "abnormality of prophase germ cell cyst" EXACT [] is_a: PLANP:0000593 ! abnormal germ cell cyst [Term] id: PLANP:0000744 name: abnormal metaphase germ cell cyst def: "Abnormality of metaphase germ cell cyst." [] synonym: "abnormality of metaphase germ cell cyst" EXACT [] is_a: PLANP:0000593 ! abnormal germ cell cyst [Term] id: PLANP:0000745 name: abnormal anaphase germ cell cyst def: "Abnormality of anaphase germ cell cyst." [] synonym: "abnormality of anaphase germ cell cyst" EXACT [] is_a: PLANP:0000593 ! abnormal germ cell cyst [Term] id: PLANP:0000746 name: abnormal telophase germ cell cyst def: "Abnormality of telophase germ cell cyst." [] synonym: "abnormality of telophase germ cell cyst" EXACT [] is_a: PLANP:0000593 ! abnormal germ cell cyst [Term] id: PLANP:0000747 name: abnormal meiotic S phase spermatocyte def: "Abnormality of meiotic S phase spermatocyte." [] synonym: "abnormality of meiotic S phase spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000748 name: abnormal meiotic G1 phase spermatocyte def: "Abnormality of meiotic G1 phase spermatocyte." [] synonym: "abnormality of meiotic G1 phase spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000749 name: abnormal meiotic G2 phase spermatocyte def: "Abnormality of meiotic G2 phase spermatocyte." [] synonym: "abnormality of meiotic G2 phase spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000750 name: abnormal meiotic prophase I spermatocyte def: "Abnormality of meiotic prophase I spermatocyte." [] synonym: "abnormality of meiotic prophase I spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000751 name: abnormal leptotene stage spermatocyte def: "Abnormality of leptotene stage spermatocyte." [] synonym: "abnormality of leptotene stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000752 name: abnormal zygotene stage spermatocyte def: "Abnormality of zygotene stage spermatocyte." [] synonym: "abnormality of zygotene stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000753 name: abnormal pachytene stage spermatocyte def: "Abnormality of pachytene stage spermatocyte." [] synonym: "abnormality of pachytene stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000754 name: abnormal diplotene stage spermatocyte def: "Abnormality of diplotene stage spermatocyte." [] synonym: "abnormality of diplotene stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000755 name: abnormal diakinesis stage spermatocyte def: "Abnormality of diakinesis stage spermatocyte." [] synonym: "abnormality of diakinesis stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000756 name: abnormal meiotic metaphase 1 stage spermatocyte def: "Abnormality of meiotic metaphase 1 stage spermatocyte." [] synonym: "abnormality of meiotic metaphase 1 stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000757 name: abnormal meiotic anaphase I stage spermatocyte def: "Abnormality of meiotic anaphase I stage spermatocyte." [] synonym: "abnormality of meiotic anaphase I stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000758 name: abnormal meiotic telophase I spermatocyte def: "Abnormality of meiotic telophase I spermatocyte." [] synonym: "abnormality of meiotic telophase I spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000759 name: abnormal meiosis II stage spermatocyte def: "Abnormality of meiosis II stage spermatocyte." [] synonym: "abnormality of meiosis II stage spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000760 name: abnormal meiotic prophase II spermatocyte def: "Abnormality of meiotic prophase II spermatocyte." [] synonym: "abnormality of meiotic prophase II spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000761 name: abnormal meiotic metaphase 2 spermatocyte def: "Abnormality of meiotic metaphase 2 spermatocyte." [] synonym: "abnormality of meiotic metaphase 2 spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000762 name: abnormal meiotic anaphase II spermatocyte def: "Abnormality of meiotic anaphase II spermatocyte." [] synonym: "abnormality of meiotic anaphase II spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000763 name: abnormal meiotic telophase II spermatocyte def: "Abnormality of meiotic telophase II spermatocyte." [] synonym: "abnormality of meiotic telophase II spermatocyte" EXACT [] is_a: PLANP:0000445 ! abnormal spermatocyte [Term] id: PLANP:0000764 name: abnormal cephalic ganglia primordium def: "Abnormality of cephalic ganglia primordium." [] synonym: "abnormality of cephalic ganglia primordium" EXACT [] is_a: PLANP:0000270 ! abnormal primordium [Term] id: PLANP:0000765 name: abnormal eye primordium def: "Abnormality of eye primordium." [] synonym: "abnormality of eye primordium" EXACT [] is_a: PLANP:0000270 ! abnormal primordium [Term] id: PLANP:0000766 name: abnormal pharynx primordium def: "Abnormality of pharynx primordium." [] synonym: "abnormality of pharynx primordium" EXACT [] is_a: PLANP:0000270 ! abnormal primordium [Term] id: PLANP:0000767 name: abnormal pigment cup primordium def: "Abnormality of pigment cup primordium." [] synonym: "abnormality of pigment cup primordium" EXACT [] is_a: PLANP:0000270 ! abnormal primordium [Term] id: PLANP:0000768 name: abnormal testis primordium def: "Abnormality of testis primordium." [] synonym: "abnormality of testis primordium" EXACT [] is_a: PLANP:0000270 ! abnormal primordium [Term] id: PLANP:0000769 name: abnormal gonad primoridium def: "Abnormality of gonad primoridium." [] synonym: "abnormality of gonad primoridium" EXACT [] is_a: PLANP:0000270 ! abnormal primordium [Term] id: PLANP:0000770 name: abnormal protonephridial lumen def: "Abnormality of protonephridial lumen." [] synonym: "abnormality of protonephridial lumen" EXACT [] is_a: PLANP:0000079 ! abnormal protonephridia is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000771 name: abnormal testis lumen def: "Abnormality of testis lumen." [] synonym: "abnormality of testis lumen" EXACT [] is_a: PLANP:0000280 ! abnormal testis is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000772 name: abnormal ovary lumen def: "Abnormality of ovary lumen." [] synonym: "abnormality of ovary lumen" EXACT [] is_a: PLANP:0000179 ! abnormal ovary is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000773 name: abnormal flame cell lumen def: "Abnormality of flame cell lumen." [] synonym: "abnormality of flame cell lumen" EXACT [] is_a: PLANP:0000230 ! abnormal flame cell is_a: PLANP:0000603 ! abnormal lumen [Term] id: PLANP:0000774 name: abnormal cephalic ganglia progenitor cell def: "Abnormality of cephalic ganglia progenitor cell." [] synonym: "abnormality of cephalic ganglia progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000775 name: abnormal dorsal epidermis progenitor cell def: "Abnormality of dorsal epidermis progenitor cell." [] synonym: "abnormality of dorsal epidermis progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000776 name: abnormal optic cup progenitor cell def: "Abnormality of optic cup progenitor cell." [] synonym: "abnormality of optic cup progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000777 name: abnormal ventral epidermis progenitor cell def: "Abnormality of ventral epidermis progenitor cell." [] synonym: "abnormality of ventral epidermis progenitor cell" EXACT [] is_a: PLANP:0000304 ! abnormal progenitor cell [Term] id: PLANP:0000778 name: abnormal head fragment def: "Abnormality of head fragment." [] synonym: "abnormality of head fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000779 name: abnormal trunk fragment def: "Abnormality of trunk fragment." [] synonym: "abnormality of trunk fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000780 name: abnormal tail fragment def: "Abnormality of tail fragment." [] synonym: "abnormality of tail fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000781 name: abnormal prepharyngeal fragment def: "Abnormality of prepharyngeal fragment." [] synonym: "abnormality of prepharyngeal fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000782 name: abnormal postpharyngeal fragment def: "Abnormality of postpharyngeal fragment." [] synonym: "abnormality of postpharyngeal fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000783 name: abnormal anterior fragment def: "Abnormality of anterior fragment." [] synonym: "abnormality of anterior fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000784 name: abnormal posterior fragment def: "Abnormality of posterior fragment." [] synonym: "abnormality of posterior fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000785 name: abnormal lateral fragment def: "Abnormality of lateral fragment." [] synonym: "abnormality of lateral fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000786 name: abnormal longitudinal fragment def: "Abnormality of longitudinal fragment." [] synonym: "abnormality of longitudinal fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000787 name: abnormal plug fragment def: "Abnormality of plug fragment." [] synonym: "abnormality of plug fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000788 name: abnormal wedge fragment def: "Abnormality of wedge fragment." [] synonym: "abnormality of wedge fragment" EXACT [] is_a: PLANP:0000673 ! abnormal fragment [Term] id: PLANP:0000789 name: head regression def: "Complete wasting (loss) of head tissue that was once present." [] synonym: "loss of head due to degeneration" EXACT [] is_a: PLANP:0000497 ! abnormal morphology of head is_a: PLANP:0000529 ! loss of head [Term] id: PLANP:0000790 name: tail regression def: "Complete wasting (loss) of tail tissue that was once present." [] synonym: "loss of tail due to degeneration" EXACT [] is_a: PLANP:0000498 ! abnormal morphology of tail is_a: PLANP:0000533 ! loss of tail [Term] id: PLANP:0000791 name: decreased mobility of animal def: "Decreased or reduced ability to move whole organism." [] is_a: PLANP:0000795 ! stationary animal [Term] id: PLANP:0000792 name: long animal def: "longer, increased length of, whole organism" [] synonym: "longer whole organism" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000793 name: increased pigmentation of the eyes def: "Increased or increasing of pigmentation of eye." [] synonym: "eye hyperpigmentation" EXACT [] synonym: "increasing of pigment in the eye" EXACT [] is_a: PLANP:0000534 ! abnormal pigmentation of the eyes [Term] id: PLANP:0000794 name: increased pigmentation of the epidermis def: "Increased or increasing of pigmentation of epidermis." [] synonym: "epidermis hyperpigmentation" EXACT [] synonym: "increasing of pigment in the epidermis" EXACT [] is_a: PLANP:0000535 ! abnormal pigmentation of the epidermis [Term] id: PLANP:0000795 name: stationary animal def: "anomaly in the ability to move whole organism." [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000796 name: epithelial ruffles def: "Any structural anomaly that causes epithelium to be ruffled shaped." [] synonym: "abnormal ruffled shape of epithelium" EXACT [] is_a: PLANP:0000665 ! abnormal epithelium [Term] id: PLANP:0000797 name: pinched head def: "Any structural anomaly that causes head to be hourglass-shaped shaped." [] synonym: "abnormal hourglass-shaped shape of head" EXACT [] is_a: PLANP:0000499 ! abnormal shape of head [Term] id: PLANP:0000798 name: pinched tail def: "Any structural anomaly that causes tail to be hourglass-shaped shaped." [] synonym: "abnormal hourglass-shaped shape of tail" EXACT [] is_a: PLANP:0000500 ! abnormal shape of tail [Term] id: PLANP:0000799 name: single sided head pinching def: "Any structural anomaly that causes head to be curved medial shaped." [] synonym: "abnormal curved medial shape of head" EXACT [] is_a: PLANP:0000499 ! abnormal shape of head [Term] id: PLANP:0000800 name: single sided tail pinching def: "Any structural anomaly that causes tail to be curved medial shaped." [] synonym: "abnormal curved medial shape of tail" EXACT [] is_a: PLANP:0000500 ! abnormal shape of tail [Term] id: PLANP:0000801 name: edema in animal def: "An abnormal accumulation of fluid in the whole organism." [] synonym: "abnormal accumulation of fluid in whole organism" EXACT [] synonym: "whole organism edema" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000802 name: head edema def: "An abnormal accumulation of fluid in the head." [] synonym: "abnormal accumulation of fluid in head" EXACT [] synonym: "head edema" EXACT [] is_a: PLANP:0000497 ! abnormal morphology of head [Term] id: PLANP:0000803 name: tail edema def: "An abnormal accumulation of fluid in the tail." [] synonym: "abnormal accumulation of fluid in tail" EXACT [] synonym: "tail edema" EXACT [] is_a: PLANP:0000498 ! abnormal morphology of tail [Term] id: PLANP:0000804 name: underdeveloped eyes def: "Small, underdeveloped eye." [] synonym: "hypoplastic eye" EXACT [] is_a: PLANP:0000046 ! abnormal eye [Term] id: PLANP:0000805 name: lesion in animal def: "An abnormal whole organism with one or more lesions." [] synonym: "whole organism with lesion(s)" EXACT [] is_a: PLANP:0000542 ! abnormal whole organism [Term] id: PLANP:0000806 name: post-pharyngeal lesion def: "An abnormal post-pharyngeal region with one or more lesions." [] synonym: "post-pharyngeal region with lesion(s)" EXACT [] is_a: PLANP:0000662 ! abnormal post-pharyngeal region [Term] id: PLANP:0000807 name: loss of pigmenation in the head def: "complete loss of pigmenation of the head." [] synonym: "absence of pigment in the head" EXACT [] synonym: "complete loss of pigmentation in the head" EXACT [] is_a: PLANP:0000810 ! abnormal pigmentation of the head [Term] id: PLANP:0000808 name: decreased pigmentation of the head def: "Decreased or loss of pigmentation of head." [] synonym: "head hypopigmentation" EXACT [] synonym: "loss of pigment in the head" EXACT [] is_a: PLANP:0000810 ! abnormal pigmentation of the head [Term] id: PLANP:0000809 name: increased pigmentation of the head def: "Increased or increasing of pigmentation of head." [] synonym: "head hyperpigmentation" EXACT [] synonym: "increasing of pigment in the head" EXACT [] is_a: PLANP:0000810 ! abnormal pigmentation of the head [Term] id: PLANP:0000810 name: abnormal pigmentation of the head def: "abnormal degree of pigmentation of the head." [] synonym: "abnormal pigmentation of the head" EXACT [] is_a: PLANP:0000497 ! abnormal morphology of head [Term] id: PLANP:0000811 name: scorpion tail def: "Any structural anomaly that causes dorsal region of tail to be curled shaped." [] synonym: "abnormal curled shape of dorsal region of tail" EXACT [] is_a: PLANP:0000036 ! abnormal tail [Term] id: PLANP:0000812 name: abnormally inchworming def: "An anomaly in inchworming behavior." [] is_a: PLANP:00000000 ! Planarian Phenotype [Term] id: PLANP:0000813 name: slow moving animal def: "slower, decreased speed of, whole organism" [] synonym: "slow moving whole organism" EXACT [] [Term] id: PLANP:0000814 name: fast moving animal def: "faster, increased speed of, whole organism" [] synonym: "fast moving whole organism" EXACT [] [Term] id: PLANP:0000815 name: immobile animal def: "anomaly in the complete lack of the ability to move of whole organism." [] is_a: PLANP:0000795 ! stationary animal [Term] id: RO:0002577 name: system def: "A material entity consisting of multiple components that are causally integrated." [] is_a: BFO:0000040 ! material entity property_value: editor_note "May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.jbiomedsem.com/content/4/1/43 xsd:string [Term] id: UBERON:0000015 name: non-material anatomical boundary namespace: uberon def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CARO:0000010] comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. subset: upper_level synonym: "anatomical boundary" EXACT [CARO:0000010] xref: AEO:0000192 xref: CARO:0000010 xref: FMA:50705 is_a: UBERON:0000466 ! immaterial anatomical entity [Term] id: UBERON:0000061 name: anatomical structure namespace: uberon def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003] subset: upper_level synonym: "biological structure" EXACT [] synonym: "connected biological structure" EXACT [CARO:0000003] xref: AAO:0010825 xref: AEO:0000003 xref: BILA:0000003 xref: CARO:0000003 xref: EHDAA2:0003003 xref: EMAPA:0 xref: FBbt:00007001 xref: FMA:305751 xref: FMA:67135 xref: GAID:781 xref: HAO:0000003 xref: http://dbpedia.org/ontology/AnatomicalStructure xref: http://www.snomedbrowser.com/Codes/Details/362889002 xref: MA:0003000 xref: MESH:D000825 xref: TAO:0000037 xref: TGMA:0001823 xref: VHOG:0001759 xref: XAO:0003000 xref: ZFA:0000037 is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000465 ! material anatomical entity relationship: existence_starts_during_or_after UBERON:0000106 ! zygote stage [Term] id: UBERON:0000068 name: embryo stage namespace: uberon def: "A life cycle stage that starts with fertilization and ends with the fully formed embryo." [http://orcid.org/0000-0002-6601-2165] synonym: "embryogenesis" RELATED [] synonym: "embryonic stage" EXACT [] xref: BilaDO:0000002 xref: EV:0300001 xref: FBdv:00005289 xref: FMA:72652 xref: HsapDv:0000002 xref: http://www.snomedbrowser.com/Codes/Details/296280003 xref: MmusDv:0000002 xref: OGES:000000 xref: OGES:000022 xref: WBls:0000003 xref: WBls:0000092 xref: WBls:0000102 xref: XAO:1000012 is_a: UBERON:0000105 ! life cycle stage [Term] id: UBERON:0000105 name: life cycle stage namespace: uberon def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: upper_level synonym: "developmental stage" NARROW [] synonym: "stage" NARROW [] xref: BILS:0000105 xref: EFO:0000399 xref: FBdv:00007012 xref: FMA:24120 xref: HsapDv:0000000 xref: MmusDv:0000000 xref: ncithesaurus:Developmental_Stage xref: OlatDv:0000010 xref: PdumDv:0000090 xref: WBls:0000002 xref: XAO:1000000 xref: ZFS:0000000 xref: ZFS:0100000 property_value: editor_note "this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here" xsd:string property_value: external_ontology_notes "the WBls class 'all stages' belongs here as it is the superclass of other WBls stages" xsd:string property_value: external_ontology_notes "we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage" xsd:string [Term] id: UBERON:0000106 name: zygote stage namespace: uberon def: "A stage at which the organism is a single cell produced by means of sexual reproduction." [http://en.wikipedia.org/wiki/Zygote] subset: efo_slim synonym: "1-cell stage" EXACT [] synonym: "fertilized egg stage" EXACT [BTO:0000854] synonym: "fertilized egg stage" RELATED [] synonym: "one cell stage" EXACT [] synonym: "one-cell stage" RELATED [VHOG:0000745] synonym: "zygote" RELATED [VHOG:0000745] synonym: "zygotum" RELATED LATIN [http://en.wikipedia.org/wiki/Zygote] xref: BilaDO:0000005 xref: BILS:0000106 xref: EFO:0001322 xref: EHDAA:27 xref: FBdv:00005288 xref: http://en.wikipedia.org/wiki/Zygote xref: NCIT:C12601 xref: PdumDv:0000100 xref: VHOG:0000745 xref: XAO:1000001 xref: ZFS:0000001 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage property_value: homology_notes "As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000745", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107"} property_value: seeAlso EMAPA:16033 [Term] id: UBERON:0000464 name: anatomical space namespace: uberon def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [http://orcid.org/0000-0001-9114-8737] subset: upper_level synonym: "anatomical spaces" RELATED PLURAL [ZFA:0001643] synonym: "lumen" BROAD [] synonym: "lumen space" EXACT [] synonym: "space" BROAD [] xref: AAO:0010110 xref: AEO:0000005 xref: BILA:0000005 xref: CARO:0000005 xref: EHDAA2:0003005 xref: FBbt:00007017 xref: FMA:5897 xref: HAO:0000005 xref: http://linkedlifedata.com/resource/umls/id/C0524461 xref: NCIT:C94478 xref: TAO:0001668 xref: TGMA:0001825 xref: UMLS:C0524461 {source="ncithesaurus:Lumen_Space"} xref: VHOG:0001728 xref: XAO:0003190 xref: ZFA:0001643 is_a: UBERON:0000466 ! immaterial anatomical entity [Term] id: UBERON:0000465 name: material anatomical entity namespace: uberon def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737] subset: upper_level xref: AAO:0010264 xref: AEO:0000006 xref: BILA:0000006 xref: CARO:0000006 xref: EHDAA2:0003006 xref: FBbt:00007016 xref: FMA:67165 xref: HAO:0000006 xref: TAO:0001836 xref: TGMA:0001826 xref: VHOG:0001721 is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000466 name: immaterial anatomical entity namespace: uberon def: "Anatomical entity that has no mass." [http://orcid.org/0000-0001-9114-8737] subset: upper_level synonym: "immaterial physical anatomical entity" EXACT [FMA:67112] xref: AAO:0010265 xref: AEO:0000007 xref: BILA:0000007 xref: CARO:0000007 xref: EHDAA2:0003007 xref: FBbt:00007015 xref: FMA:67112 xref: HAO:0000007 xref: TAO:0001835 xref: TGMA:0001827 xref: VHOG:0001727 is_a: UBERON:0001062 ! anatomical entity [Term] id: UBERON:0000475 name: organism subdivision namespace: uberon def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [CARO:0000032, CARO:DOS, http://orcid.org/0000-0001-9114-8737] subset: efo_slim subset: pheno_slim subset: uberon_slim subset: upper_level synonym: "anatomic region" EXACT [MA:0002433] synonym: "body part" RELATED [] synonym: "body region" RELATED [FMA:7153] synonym: "cardinal body part" RELATED [FMA:7153] xref: AAO:0010053 xref: AEO:0000032 xref: BILA:0000032 xref: BIRNLEX:7 xref: Body:part xref: CALOHA:TS-2084 xref: CARO:0000032 xref: EFO:0000808 xref: EHDAA2:0003032 xref: EMAPA:36031 xref: FBbt:00007009 xref: FMA:7153 xref: galen:BodyPart xref: HAO:0000032 xref: http://linkedlifedata.com/resource/umls/id/C0229962 xref: MA:0002433 xref: MAT:0000293 xref: MESH:D001829 xref: MIAA:0000293 xref: NCIT:C32221 xref: OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA xref: TAO:0001308 xref: TGMA:0001840 xref: UMLS:C0229962 {source="ncithesaurus:Body_Part"} xref: VHOG:0001758 xref: XAO:0003013 xref: ZFA:0001308 is_a: UBERON:0000061 ! anatomical structure property_value: editor_note "Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency" xsd:string [Term] id: UBERON:0000476 name: acellular anatomical structure namespace: uberon def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [http://orcid.org/0000-0001-9114-8737] subset: vertebrate_core synonym: "acellular anatomical structures" RELATED PLURAL [ZFA:0000382] xref: AAO:0010268 xref: AEO:0000040 xref: BILA:0000040 xref: CARO:0000040 xref: EHDAA2:0003040 xref: FBbt:00007013 xref: FMA:63863 xref: HAO:0000040 xref: TAO:0000382 xref: TGMA:0001841 xref: XAO:0003162 xref: ZFA:0000382 is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0001062 name: anatomical entity namespace: uberon def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737] subset: upper_level xref: AAO:0010841 xref: AEO:0000000 xref: BILA:0000000 xref: BIRNLEX:6 xref: CARO:0000000 xref: EHDAA2:0002229 xref: FBbt:10000000 xref: FBbt_root:00000000 xref: FMA:62955 xref: HAO:0000000 xref: http://linkedlifedata.com/resource/umls/id/C1515976 xref: MA:0000001 xref: NCIT:C12219 xref: TAO:0100000 xref: TGMA:0001822 xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance"} xref: WBbt:0000100 xref: XAO:0000000 xref: ZFA:0100000 [Term] id: UBERON:0002553 name: anatomical cavity namespace: uberon def: "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." [FMA:67552] subset: upper_level synonym: "cavity" BROAD [] xref: BIRNLEX:1011 xref: EMAPA:37442 {source="MA:th"} xref: FMA:67552 xref: galen:Cavity xref: MA:0002447 xref: NCIT:C34007 is_a: UBERON:0000464 ! anatomical space [Term] id: UBERON:0005423 name: developing anatomical structure namespace: uberon synonym: "developing structure" RELATED [] synonym: "developmental structure" RELATED [] synonym: "developmental tissue" RELATED [MIAA:0000019] xref: AEO:0000125 xref: CALOHA:TS-2122 xref: EHDAA2:0003125 xref: FBbt:00007006 xref: FMA:292313 xref: MIAA:0000019 is_a: UBERON:0000465 ! material anatomical entity [Term] id: UBERON:0006983 name: anatomical point namespace: uberon def: "Non-material anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface." [FMA:9658, http://orcid.org/0000-0001-9114-8737] subset: upper_level xref: AAO:0010266 xref: AEO:0000009 xref: BILA:0000009 xref: CARO:0000009 xref: EHDAA2:0003009 xref: FMA:9658 xref: TAO:0001839 is_a: UBERON:0000466 ! immaterial anatomical entity [Term] id: UBERON:0007567 name: regenerating anatomical structure namespace: uberon alt_id: EHDAA2:0003233 def: "An anatomical structure that is undergoing regeneration." [http://orcid.org/0000-0002-6601-2165] synonym: "regenerating tissue" RELATED [ZFA:0005147] synonym: "regenerating tissues" RELATED PLURAL [ZFA:0005147] synonym: "regenerative tissue" RELATED [] xref: AEO:0000200 xref: EHDAA2:0003233 xref: TAO:0005147 xref: XAO:0004059 xref: ZFA:0005147 is_a: UBERON:0000061 ! anatomical structure property_value: editor_note "we define this in terms of active participation in regeneration, rather that capabilities. In this sense it is different from the AEO structure." xsd:string property_value: external_definition "A portion of tissue that is regrowing after damage or amputation.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005147", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0007651 name: anatomical junction namespace: uberon def: "An anatomical structure that connects two structures" [http://code.google.com/p/caro2/issues/detail?id=15] subset: upper_level synonym: "anatomical junction" EXACT [] synonym: "junction" BROAD [] xref: FMA:5898 xref: http://www.snomedbrowser.com/Codes/Details/91833003 is_a: UBERON:0000061 ! anatomical structure [Term] id: UBERON:0035086 name: plane of autotomy namespace: uberon def: "An anatomical plane that bisects a zone of weakness in an appendage. When autotamy occurs, the appendage divides along this plane." [http://en.wikipedia.org/wiki/Autotomy, http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000466 ! immaterial anatomical entity property_value: curator_notes "this class is intended for autotomy that bisects an appendage. Other forms of autotomy are possible: for example, a sea cucumber and autotomitize internal organs" xsd:string [Term] id: UPHENO:0001001 name: phenotype is_a: PATO:0000001 ! quality [Typedef] id: IAO:0000136 name: is about def: "is_about is a (currently) primitive relation that relates an information artifact to an entity." [] property_value: editor_note "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic." xsd:string property_value: example_of_usage "This document is about information artifacts and their representations" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "person:Alan Ruttenberg" xsd:string property_value: IAO:0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" xsd:string [Typedef] id: RO:0000052 name: inheres in def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" [] property_value: editor_note "A dependent inheres in its bearer at all times for which the dependent exists." xsd:string property_value: example_of_usage "this fragility inheres in this vase" xsd:string property_value: example_of_usage "this red color inheres in this apple" xsd:string property_value: IAO:0000111 "inheres in" xsd:string property_value: IAO:0000118 "inheres_in" xsd:string property_value: RO:0001900 RO:0001901 is_a: RO:0002314 ! inheres in part of inverse_of: bearer_of ! bearer of [Typedef] id: RO:0000056 name: participates in def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" [] property_value: example_of_usage "this blood clot participates in this blood coagulation" xsd:string property_value: example_of_usage "this input material (or this output material) participates in this process" xsd:string property_value: example_of_usage "this investigator participates in this investigation" xsd:string property_value: IAO:0000111 "participates in" xsd:string property_value: IAO:0000118 "participates_in" xsd:string domain: BFO:0000002 ! continuant range: BFO:0000003 ! occurrent inverse_of: RO:0000057 ! has participant [Typedef] id: RO:0000057 name: has participant def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] property_value: dc-source http://www.obofoundry.org/ro/#OBO_REL:has_participant xsd:string property_value: editor_note "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string property_value: example_of_usage "this blood coagulation has participant this blood clot" xsd:string property_value: example_of_usage "this investigation has participant this investigator" xsd:string property_value: example_of_usage "this process has participant this input material (or this output material)" xsd:string property_value: IAO:0000111 "has participant" xsd:string property_value: IAO:0000118 "has_participant" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000002 ! continuant holds_over_chain: has_part RO:0000057 [Typedef] id: RO:0000080 name: quality of def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" [] property_value: editor_note "A quality inheres in its bearer at all times for which the quality exists." xsd:string property_value: example_of_usage "this red color is a quality of this apple" xsd:string property_value: IAO:0000118 "is quality of" xsd:string property_value: IAO:0000118 "quality_of" xsd:string is_a: RO:0000052 ! inheres in inverse_of: RO:0000086 ! has quality [Typedef] id: RO:0000086 name: has quality def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" [] property_value: editor_note "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist." xsd:string property_value: example_of_usage "this apple has quality this red color" xsd:string property_value: IAO:0000118 "has_quality" xsd:string range: BFO:0000019 ! quality is_a: bearer_of ! bearer of [Typedef] id: RO:0001000 name: derives from def: "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] subset: ro-eco property_value: curator_notes "This relation is taken from the RO2005 version of RO. It may be obsoleted and replaced by relations with different definitions. See also the 'develops from' family of relations." xsd:string property_value: editor_note "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'." xsd:string property_value: example_of_usage "this cell derives from this parent cell (cell division)" xsd:string property_value: example_of_usage "this nucleus derives from this parent nucleus (nuclear division)" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000118 "derives_from" xsd:string inverse_of: RO:0001001 ! derives into [Typedef] id: RO:0001001 name: derives into def: "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] subset: ro-eco property_value: editor_note "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'." xsd:string property_value: example_of_usage "this parent cell derives into this cell (cell division)" xsd:string property_value: example_of_usage "this parent nucleus derives into this nucleus (nuclear division)" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000118 "derives_into" xsd:string [Typedef] id: RO:0001015 name: location of def: "a relation between two independent continuants, the location and the target, in which the target is entirely within the location" [] property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: example_of_usage "my head is the location of my brain" xsd:string property_value: example_of_usage "this cage is the location of this rat" xsd:string property_value: IAO:0000111 "is location of" xsd:string property_value: IAO:0000118 "location_of" xsd:string property_value: RO:0001900 RO:0001901 is_transitive: true inverse_of: RO:0001025 ! located in [Typedef] id: RO:0001018 name: contained in subset: ro-eco property_value: editor_note "Containment is location not involving parthood, and arises only where some immaterial continuant is involved." xsd:string property_value: editor_note "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):" xsd:string property_value: editor_note "Intended meaning:\ndomain: material entity\nrange: spatial region or site (immaterial continuant)\n " xsd:string property_value: IAO:0000111 "contained in" xsd:string property_value: IAO:0000118 "contained_in" xsd:string property_value: RO:0001900 RO:0001901 domain: BFO:0000040 ! material entity range: BFO:0000004 ! independent continuant holds_over_chain: RO:0001025 part_of inverse_of: contains ! contains [Typedef] id: RO:0001025 name: located in def: "a relation between two independent continuants, the target and the location, in which the target is entirely within the location" [] property_value: dc-source http://www.obofoundry.org/ro/#OBO_REL:located_in xsd:string property_value: editor_note "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus" xsd:string property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: example_of_usage "my brain is located in my head" xsd:string property_value: example_of_usage "this rat is located in this cage" xsd:string property_value: IAO:0000111 "located in" xsd:string property_value: IAO:0000118 "located_in" xsd:string property_value: RO:0001900 RO:0001901 domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant is_transitive: true transitive_over: part_of ! part_of [Typedef] id: RO:0002013 name: has regulatory component activity def: "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." [] is_a: RO:0002017 ! has component activity is_a: RO:0002334 ! regulated by created_by: dos creation_date: 2017-05-24T09:30:46Z [Typedef] id: RO:0002014 name: has negative regulatory component activity def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." [] comment: By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'. is_a: RO:0002013 ! has regulatory component activity is_a: RO:0002335 ! negatively regulated by created_by: dos creation_date: 2017-05-24T09:31:01Z [Typedef] id: RO:0002015 name: has positive regulatory component activity def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." [] comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'. is_a: RO:0002013 ! has regulatory component activity is_a: RO:0002336 ! positively regulated by created_by: dos creation_date: 2017-05-24T09:31:17Z [Typedef] id: RO:0002017 name: has component activity comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B. is_a: RO:0002018 ! has component process created_by: dos creation_date: 2017-05-24T09:44:33Z [Typedef] id: RO:0002018 name: has component process def: "w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] domain: BFO:0000015 ! process range: BFO:0000015 ! process is_a: has_component ! has component created_by: dos creation_date: 2017-05-24T09:49:21Z [Typedef] id: RO:0002019 name: has ligand def: "A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function." [] domain: GO:0004872 is_a: RO:0002233 ! has input created_by: dos creation_date: 2017-07-19T17:30:36Z [Typedef] id: RO:0002022 name: directly regulated by comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="GOC:dos"} is_a: RO:0002334 ! regulated by inverse_of: RO:0002578 ! directly regulates created_by: dos creation_date: 2017-09-17T13:52:24Z [Typedef] id: RO:0002023 name: directly negatively regulated by def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [GOC:dos] is_a: RO:0002022 ! directly regulated by inverse_of: RO:0002630 ! directly negatively regulates created_by: dos creation_date: 2017-09-17T13:52:38Z [Typedef] id: RO:0002024 name: directly positively regulated by def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [GOC:dos] is_a: RO:0002022 ! directly regulated by inverse_of: RO:0002629 ! directly positively regulates created_by: dos creation_date: 2017-09-17T13:52:47Z [Typedef] id: RO:0002025 name: has effector activity def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [GOC:dos] comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations. is_functional: true is_a: regulates ! regulates is_a: RO:0002017 ! has component activity created_by: dos creation_date: 2017-09-22T14:14:36Z [Typedef] id: RO:0002081 name: before or simultaneous with comment: Primitive instance level timing relation between events subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "<=" xsd:string is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002082 name: simultaneous with comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string is_transitive: true is_a: RO:0002081 ! before or simultaneous with [Typedef] id: RO:0002084 name: during which ends comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002122 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range. subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string is_a: RO:0002222 ! temporally related to inverse_of: ends_during ! ends_during [Typedef] id: RO:0002085 name: encompasses comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002124 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range. property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "di" xsd:string is_transitive: true is_a: RO:0002088 ! during which starts inverse_of: happens_during ! happens during [Typedef] id: RO:0002086 name: ends after comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string holds_over_chain: ends_during preceded_by is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002088 name: during which starts comment: Previously had ID http://purl.obolibrary.org/obo/RO_0002123 in test files in sandpit - but this seems to have been dropped from ro-edit.owl at some point. No re-use under this ID AFAIK, but leaving note here in case we run in to clashes down the line. Official ID now chosen from DOS ID range. subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string is_a: RO:0002222 ! temporally related to inverse_of: starts_during ! starts_during [Typedef] id: RO:0002090 name: immediately precedes comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) subset: ro-eco property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "ends_at_start_of" xsd:string property_value: IAO:0000118 "meets" xsd:string property_value: RO:0002575 BFO:0000063 holds_over_chain: RO:0002230 RO:0002224 is_a: precedes ! precedes [Typedef] id: RO:0002104 name: has plasma membrane part def: "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." [] property_value: example_of_usage "Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Alexander Diehl" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Lindsay Cowell" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/19243617 property_value: RO:0001900 RO:0001901 domain: CARO:0000006 ! material anatomical entity range: CARO:0000006 ! material anatomical entity is_a: has_part ! has part expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" [] [Typedef] id: RO:0002156 name: derived by descent from def: "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a." [] property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000118 "ancestral_stucture_of" xsd:string property_value: IAO:0000118 "evolutionarily_descended_from" xsd:string is_transitive: true is_a: RO:0002320 ! evolutionarily related to inverse_of: RO:0002157 ! has derived by descendant [Typedef] id: RO:0002157 name: has derived by descendant def: "inverse of derived by descent from" [] subset: RO:0002259 property_value: IAO:0000114 IAO:0000125 is_transitive: true is_a: RO:0002320 ! evolutionarily related to [Typedef] id: RO:0002158 name: shares ancestor with def: "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." [] comment: VBO calls this homologous_to property_value: curator_notes "Consider obsoleting and merging with child relation, 'in homology relationship with'" xsd:string property_value: IAO:0000114 IAO:0000125 holds_over_chain: RO:0002156 RO:0002157 is_symmetric: true is_transitive: true is_a: RO:0002320 ! evolutionarily related to [Typedef] id: RO:0002159 name: serially homologous to property_value: IAO:0000114 IAO:0000125 is_symmetric: true is_transitive: true is_a: RO:0002320 ! evolutionarily related to [Typedef] id: RO:0002160 name: only in taxon def: "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." [] property_value: editor_note "The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g.\n\n 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria" xsd:string property_value: example_of_usage "lactation SubClassOf 'only in taxon' some 'Mammalia'" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/17921072 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20973947 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints is_a: RO:0002162 ! in taxon [Typedef] id: RO:0002162 name: in taxon def: "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." [] comment: Connects a biological entity to its taxon of origin. subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Jennifer Deegan" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/17921072 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20973947 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints range: CARO:0001010 ! organism or virus or viroid holds_over_chain: capable_of RO:0002162 holds_over_chain: develops_from RO:0002162 holds_over_chain: has_developmental_contribution_from RO:0002162 holds_over_chain: has_part RO:0002162 holds_over_chain: part_of RO:0002162 holds_over_chain: RO:0002225 RO:0002162 is_a: RO:0002320 ! evolutionarily related to [Typedef] id: RO:0002163 name: spatially disjoint from def: "A is spatially_disjoint_from B if and only if they have no parts in common" [] subset: ro-eco property_value: curator_notes "Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy" xsd:string property_value: editor_note "There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. " xsd:string property_value: foaf-page https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern xsd:anyURI property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/22293552 property_value: RO:0001900 RO:0001901 is_a: RO:0002323 ! mereotopologically related to expand_expression_to: "BFO_0000051 exactly 0 (BFO_0000050 some ?Y)" [] [Typedef] id: RO:0002170 name: connected to def: "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" [] property_value: example_of_usage "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." xsd:string property_value: foaf-page https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern xsd:anyURI property_value: foaf-page https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern xsd:anyURI property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/22293552 is_a: RO:0002323 ! mereotopologically related to [Typedef] id: RO:0002177 name: attached to part of def: "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." [] property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string domain: CARO:0000003 ! anatomical structure range: CARO:0000003 ! anatomical structure holds_over_chain: RO:0002371 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: RO:0002323 ! mereotopologically related to is_a: RO:0002567 ! biomechanically related to [Typedef] id: RO:0002200 name: has phenotype def: "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string range: UPHENO:0001001 ! phenotype inverse_of: RO:0002201 ! phenotype of [Typedef] id: RO:0002201 name: phenotype of def: "inverse of has phenotype" [] subset: ro-eco subset: RO:0002259 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string is_functional: true [Typedef] id: RO:0002207 name: directly develops from def: "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." [] comment: TODO - add child relations from DOS property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000117 "has developmental precursor" xsd:string property_value: IAO:0000119 "FBbt" xsd:string property_value: RO:0002575 RO:0002202 is_a: develops_from ! develops from inverse_of: RO:0002210 ! directly develops into [Typedef] id: RO:0002210 name: directly develops into def: "inverse of directly develops from" [] subset: RO:0002259 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000118 "developmental precursor of" xsd:string is_a: develops_into ! develops_into [Typedef] id: RO:0002217 name: actively participates in name: obsolete actively participates in def: "OBSOLETE x actively participates in y if and only if x participates in y and x realizes some active role" [] def: "x actively participates in y if and only if x participates in y and x realizes some active role" [] comment: Obsoleted as the inverse property was obsoleted. property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "agent in" xsd:string is_a: RO:0000056 ! participates in inverse_of: RO:0002218 ! obsolete has active participant is_obsolete: true [Typedef] id: RO:0002218 name: obsolete has active participant def: "x has participant y if and only if x realizes some active role that inheres in y" [] subset: ro-eco property_value: editor_note "This may be obsoleted and replaced by the original 'has agent' relation" xsd:string property_value: example_of_usage "'heart development' has active participant some Shh protein" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has agent" xsd:string is_a: RO:0000057 ! has participant is_obsolete: true [Typedef] id: RO:0002219 name: surrounded by def: "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" [] property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0001900 RO:0001901 is_a: adjacent_to ! adjacent_to inverse_of: RO:0002221 ! surrounds [Typedef] id: RO:0002221 name: surrounds def: "inverse of surrounded by" [] subset: RO:0002259 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0001900 RO:0001901 is_a: adjacent_to ! adjacent_to [Typedef] id: RO:0002222 name: temporally related to comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. subset: ro-eco property_value: curator_notes "Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends." xsd:string property_value: http://purl.org/dc/terms/source https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 xsd:anyURI property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 https://en.wikipedia.org/wiki/Allen%27s_interval_algebra domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent [Typedef] id: RO:0002223 name: starts def: "inverse of starts with" [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 "Allen" xsd:string is_a: part_of ! part_of is_a: RO:0002222 ! temporally related to inverse_of: RO:0002224 ! starts with [Typedef] id: RO:0002224 name: starts with def: "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco property_value: example_of_usage "Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "started by" xsd:string is_transitive: true is_a: has_part ! has part is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002225 name: develops from part of def: "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" [] property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: RO:0002207 part_of is_a: develops_from ! develops from [Typedef] id: RO:0002226 name: develops in def: "x develops_in y if x is located in y whilst x is developing" [] property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 "EHDAA2" xsd:string property_value: IAO:0000119 "Jonathan Bard, EHDAA2" xsd:string domain: CARO:0000000 ! anatomical entity holds_over_chain: RO:0002207 RO:0001025 is_a: developmentally_preceded_by ! developmentally preceded by [Typedef] id: RO:0002229 name: ends def: "inverse of ends with" [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: part_of ! part_of is_a: RO:0002222 ! temporally related to inverse_of: RO:0002230 ! ends with [Typedef] id: RO:0002230 name: ends with def: "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "finished by" xsd:string is_transitive: true is_a: has_part ! has part is_a: RO:0002222 ! temporally related to [Typedef] id: RO:0002231 name: has start location def: "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "starts with process that occurs in" xsd:string domain: BFO:0000015 ! process range: BFO:0000004 ! independent continuant holds_over_chain: RO:0002224 occurs_in is_a: RO:0002479 ! has part that occurs in [Typedef] id: RO:0002232 name: has end location def: "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "ends with process that occurs in" xsd:string domain: BFO:0000015 ! process range: BFO:0000004 ! independent continuant holds_over_chain: RO:0002230 occurs_in is_a: RO:0002479 ! has part that occurs in [Typedef] id: RO:0002233 name: has input def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." [] subset: ro-eco property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "consumes" xsd:string domain: BFO:0000015 ! process range: BFO:0000040 ! material entity holds_over_chain: RO:0002224 RO:0002233 is_a: RO:0000057 ! has participant inverse_of: input_of ! input of [Typedef] id: RO:0002256 name: developmentally induced by def: "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T" [] property_value: curator_notes "We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000117 "Melissa Haendel" xsd:string property_value: IAO:0000118 "induced by" xsd:string property_value: IAO:0000119 " Developmental Biology, Gilbert, 8th edition, figure 6.5(F)" xsd:string property_value: IAO:0000119 GO:0001759 xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 domain: CARO:0000003 ! anatomical structure range: CARO:0000003 ! anatomical structure is_a: developmentally_preceded_by ! developmentally preceded by inverse_of: RO:0002257 ! developmentally induces [Typedef] id: RO:0002257 name: developmentally induces def: "Inverse of developmentally induced by" [] property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002286 ! developmentally succeeded by is_a: RO:0002386 ! has potential to developmentally induce [Typedef] id: RO:0002263 name: acts upstream of def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." [] property_value: example_of_usage "A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision." xsd:string property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of holds_over_chain: RO:0002327 RO:0002411 is_a: RO:0002264 ! acts upstream of or within [Typedef] id: RO:0002264 name: acts upstream of or within def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." [] synonym: "affects" RELATED [] property_value: example_of_usage "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." xsd:string property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within holds_over_chain: RO:0002327 RO:0002418 is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002285 name: developmentally replaces def: "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" [] property_value: editor_note "This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "replaces" xsd:string is_a: developmentally_preceded_by ! developmentally preceded by [Typedef] id: RO:0002286 name: developmentally succeeded by def: "Inverse of developmentally preceded by" [] property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002384 ! has developmental potential involving [Typedef] id: RO:0002287 name: part of developmental precursor of property_value: example_of_usage "'hypopharyngeal eminence' SubClassOf 'part of precursor of' some tongue" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: part_of RO:0002210 is_a: RO:0002286 ! developmentally succeeded by [Typedef] id: RO:0002304 name: causally upstream of, positive effect comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y property_value: http://purl.org/dc/terms/creator "cjm" xsd:string property_value: RO:0004049 RO:0002411 is_a: RO:0002411 ! causally upstream of is_a: RO:0004047 ! causally upstream of or within, positive effect [Typedef] id: RO:0002305 name: causally upstream of, negative effect comment: holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y property_value: http://purl.org/dc/terms/creator "cjm" xsd:string property_value: RO:0004050 RO:0002411 is_a: RO:0002411 ! causally upstream of is_a: RO:0004046 ! causally upstream of or within, negative effect [Typedef] id: RO:0002314 name: inheres in part of def: "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." [] property_value: editor_note "Because part_of is transitive, inheres in is a sub-relation of inheres in part of" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 property_value: RO:0001900 RO:0001901 property_value: seeAlso "defining-property-chains-involving-reflexivity" holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: RO:0002502 ! depends on transitive_over: part_of ! part_of [Typedef] id: RO:0002320 name: evolutionarily related to def: "A relationship that holds via some environmental process" [] property_value: curator_notes "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string [Typedef] id: RO:0002321 name: ecologically related to def: "A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)" [] subset: ro-eco property_value: curator_notes "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving ecological interactions" xsd:string property_value: editor_note "Awaiting class for domain/range constraint, see: https://github.com/OBOFoundry/Experimental-OBO-Core/issues/6" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string [Typedef] id: RO:0002322 name: confers advantage in subset: ro-eco property_value: editor_note "An experimental relation currently used to connect a feature possessed by an organism (e.g. anatomical structure, biological process, phenotype or quality) to a habitat or environment in which that feature is well suited, adapted or provides a reproductive advantage for the organism. For example, fins to an aquatic environment. Usually this will mean that the structure is adapted for this environment, but we avoid saying this directly - primitive forms of the structure may not have evolved specifically for that environment (for example, early wings were not necessarily adapted for an aerial environment). Note also that this is a statement about the general class of structures - not every instance of a limb need confer an advantage for a terrestrial environment, e.g. if the limb is vestigial." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "adapted for" xsd:string range: ENVO:01000254 ! environmental system is_a: RO:0002321 ! ecologically related to [Typedef] id: RO:0002323 name: mereotopologically related to def: "A mereological relationship or a topological relationship" [] property_value: curator_notes "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0001900 RO:0001901 [Typedef] id: RO:0002324 name: developmentally related to def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" [] property_value: curator_notes "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string [Typedef] id: RO:0002326 name: contributes to property_value: curator_notes "In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology. " xsd:string property_value: editor_note "We would like to say\n\nif and only if\n exists c', p'\n c part_of c' and c' capable_of p\n and\n c capable_of p' and p' part_of p\nthen\n c contributes_to p\n\nHowever, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction." xsd:string property_value: example_of_usage "ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity." xsd:string property_value: example_of_usage "eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to \"ribosome binding\". And all three are part_of an eIF2 complex" xsd:string property_value: example_of_usage "Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to xsd:string is_a: capable_of_part_of ! capable of part of is_a: part_of_structure_that_is_capable_of ! part of structure that is capable of [Typedef] id: RO:0002327 name: enables property_value: curator_notes "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string property_value: curator_notes "This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time." xsd:string property_value: example_of_usage "a particular instances of akt-2 enables some instance of protein kinase activity" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "catalyzes" xsd:string property_value: IAO:0000118 "executes" xsd:string property_value: IAO:0000118 "has" xsd:string property_value: IAO:0000118 "is catalyzing" xsd:string property_value: IAO:0000118 "is executing" xsd:string is_a: capable_of ! capable of inverse_of: RO:0002333 ! enabled by transitive_over: has_part ! has part transitive_over: RO:0002017 ! has component activity [Typedef] id: RO:0002331 name: involved in def: "c involved_in p if and only if c enables some process p', and p' is part of p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "actively involved in" xsd:string property_value: IAO:0000118 "enables part of" xsd:string property_value: seeAlso Involved:in holds_over_chain: RO:0002327 part_of is_a: RO:0000056 ! participates in is_a: RO:0002217 ! obsolete actively participates in is_a: RO:0002431 ! involved in or involved in regulation of transitive_over: part_of ! part_of [Typedef] id: RO:0002333 name: enabled by def: "inverse of enables" [] property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: functionally_related_to ! functionally related to is_a: RO:0000057 ! has participant [Typedef] id: RO:0002334 name: regulated by def: "inverse of regulates" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000589 "regulated by (processual)" xsd:string domain: BFO:0000015 ! process range: BFO:0000015 ! process is_transitive: true is_a: RO:0002427 ! causally downstream of or within [Typedef] id: RO:0002335 name: negatively regulated by def: "inverse of negatively regulates" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002334 ! regulated by [Typedef] id: RO:0002336 name: positively regulated by def: "inverse of positively regulates" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002334 ! regulated by [Typedef] id: RO:0002371 name: attached to def: "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" [] subset: ro-eco property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000589 "attached to (anatomical structure to anatomical structure)" xsd:string is_symmetric: true is_a: RO:0002170 ! connected to is_a: RO:0002177 ! attached to part of [Typedef] id: RO:0002372 name: has muscle origin def: "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 Wikipedia:Insertion_(anatomy) xsd:string property_value: seeAlso http://dbpedia.org/property/origin domain: CARO:0000003 {comment="We need to import uberon muscle to create a stricter domain constraint"} ! anatomical structure is_a: RO:0002371 ! attached to is_a: RO:0002567 ! biomechanically related to [Typedef] id: RO:0002373 name: has muscle insertion def: "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 Wikipedia:Insertion_(anatomy) xsd:string property_value: seeAlso http://dbpedia.org/property/insertion domain: CARO:0000003 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure is_a: RO:0002371 ! attached to is_a: RO:0002567 ! biomechanically related to [Typedef] id: RO:0002374 name: derived from ancestral fusion of def: "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat" [] comment: A has_fused_element B does not imply that A has_part some B: rather than A has_part some B', where B' that has some evolutionary relationship to B. synonym: "has fused element" BROAD [] property_value: example_of_usage "false" xsd:boolean property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/22293552 is_a: RO:0002156 ! derived by descent from [Typedef] id: RO:0002379 name: spatially coextensive with def: "x spatially_coextensive_with y if and inly if x and y have the same location" [] property_value: curator_notes "This relation is added for formal completeness. It is unlikely to be used in many practical scenarios" xsd:string property_value: example_of_usage "A lump of clay and a statue" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: overlaps ! overlaps [Typedef] id: RO:0002384 name: has developmental potential involving def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string domain: CARO:0000000 ! anatomical entity range: CARO:0000000 ! anatomical entity is_a: RO:0002324 ! developmentally related to [Typedef] id: RO:0002386 name: has potential to developmentally induce def: "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y" [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002384 ! has developmental potential involving [Typedef] id: RO:0002404 name: causally downstream of def: "inverse of upstream of" [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: preceded_by ! preceded_by is_a: RO:0002427 ! causally downstream of or within inverse_of: RO:0002411 ! causally upstream of [Typedef] id: RO:0002405 name: immediately causally downstream of property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: immediately_preceded_by ! immediately preceded by is_a: RO:0002404 ! causally downstream of inverse_of: RO:0002412 ! immediately causally upstream of [Typedef] id: RO:0002410 name: causally related to def: "This relation groups causal relations between material entities and causal relations between processes" [] property_value: curator_notes "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string property_value: editor_note "This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.\n\nTo define causal relations in an activity-flow type network, we make use of 3 primitives:\n\n * Temporal: how do the intervals of the two occurrents relate? \n * Is the causal relation regulatory?\n * Is the influence positive or negative\n\nThe first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.\n\nFor the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.\n\nFor the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.\n\nEach of these 3 primitives can be composed to yield a cross-product of different relation types." xsd:string property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string [Typedef] id: RO:0002411 name: causally upstream of def: "p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain" [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_transitive: true is_a: precedes ! precedes is_a: RO:0002418 ! causally upstream of or within [Typedef] id: RO:0002412 name: immediately causally upstream of def: "p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q." [] property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0002575 RO:0002411 is_a: RO:0002090 ! immediately precedes is_a: RO:0002411 ! causally upstream of [Typedef] id: RO:0002418 name: causally upstream of or within def: "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." [] synonym: "affects" RELATED [] property_value: editor_note "We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "influences (processual)" xsd:string is_transitive: true is_a: RO:0002501 ! causal relation between processes inverse_of: RO:0002427 ! causally downstream of or within [Typedef] id: RO:0002427 name: causally downstream of or within def: "inverse of causally upstream of or within" [] subset: RO:0002259 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_transitive: true is_a: RO:0002501 ! causal relation between processes [Typedef] id: RO:0002428 name: involved in regulation of def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: RO:0002327 regulates holds_over_chain: RO:0002331 regulates is_a: RO:0002263 ! acts upstream of is_a: RO:0002431 ! involved in or involved in regulation of [Typedef] id: RO:0002429 name: involved in positive regulation of def: "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0004049 RO:0002428 holds_over_chain: RO:0002327 positively_regulates holds_over_chain: RO:0002331 positively_regulates is_a: RO:0002428 ! involved in regulation of [Typedef] id: RO:0002430 name: involved in negative regulation of def: "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0004050 RO:0002428 holds_over_chain: RO:0002327 negatively_regulates holds_over_chain: RO:0002331 negatively_regulates is_a: RO:0002428 ! involved in regulation of [Typedef] id: RO:0002431 name: involved in or involved in regulation of def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" [] property_value: editor_note "OWL does not allow defining object properties via a Union" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "involved in or reguates" xsd:string is_a: functionally_related_to ! functionally related to is_a: RO:0002264 ! acts upstream of or within is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002432 name: is active in def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [GOC:cjm, GOC:dos] synonym: "enables activity in" EXACT [] property_value: example_of_usage "A protein that enables activity in a cytosol." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "executes activity in" xsd:string holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"} is_a: functionally_related_to ! functionally related to is_a: overlaps ! overlaps [Typedef] id: RO:0002434 name: interacts with def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." [] subset: ro-eco synonym: "in pairwise interaction with" EXACT [] property_value: curator_notes "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." xsd:string property_value: editor_note "Considering relabeling as 'pairwise interacts with'" xsd:anyURI property_value: editor_note "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." xsd:string property_value: foaf-page https://github.com/oborel/obo-relations/wiki/InteractionRelations xsd:anyURI property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: seeAlso http://purl.obolibrary.org/obo/MI_0914 xsd:anyURI domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_symmetric: true [Typedef] id: RO:0002436 name: molecularly interacts with def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "binds" xsd:string property_value: IAO:0000118 "molecularly binds with" xsd:string property_value: seeAlso ECO:0000353 property_value: seeAlso http://purl.obolibrary.org/obo/MI_0915 xsd:anyURI is_symmetric: true is_a: RO:0002434 ! interacts with [Typedef] id: RO:0002447 name: phosphorylates property_value: editor_note "Axiomatization to GO to be added later" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y." xsd:string is_a: RO:0002436 ! molecularly interacts with [Typedef] id: RO:0002448 name: activity directly regulates activity of name: directly regulates activity of def: "Holds between molecular entities A and B where A can physically interact with B and in doing so regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B." [] def: "The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.\n\nA and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B." [] synonym: "molecularly controls" EXACT [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Vasundra Touré" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002436 ! molecularly interacts with is_a: RO:0002566 ! causally influences is_a: RO:0011002 ! regulates activity of [Typedef] id: RO:0002449 name: activity directly negatively regulates activity of name: directly negatively regulates activity of def: "Holds between molecular entities A and B where A can physically interact with B and in doing so negatively regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." [] def: "The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." [] synonym: "molecularly decreases activity of" EXACT [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Vasundra Touré" xsd:string property_value: IAO:0000118 "directly inhibits" xsd:string property_value: IAO:0000118 "inhibits" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002448 ! directly regulates activity of [Typedef] id: RO:0002450 name: activity directly positively regulates activity of name: directly positively regulates activity of def: "Holds between molecular entities A and B where A can physically interact with B and in doing so positively regulates a process that B is capable of. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." [] def: "The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." [] synonym: "molecularly increases activity of" EXACT [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Vasundra Touré" xsd:string property_value: IAO:0000118 "activates" xsd:string property_value: IAO:0000118 "directly activates" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002448 ! directly regulates activity of [Typedef] id: RO:0002464 name: helper property (not for use in curation) property_value: curator_notes "This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string [Typedef] id: RO:0002465 name: is symbiosis property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002563 ! interaction relation helper property [Typedef] id: RO:0002473 name: composed primarily of def: "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." [] subset: ro-eco property_value: example_of_usage "'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/22293552 property_value: RO:0001900 RO:0001901 domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: has_part ! has part [Typedef] id: RO:0002479 name: has part that occurs in def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." [] subset: ro-eco property_value: IAO:0000117 "Chris Mungall" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"} [Typedef] id: RO:0002481 name: is kinase activity property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002564 ! molecular interaction relation helper property [Typedef] id: RO:0002487 name: relation between physical entity and a process or stage property_value: curator_notes "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string domain: BFO:0000004 ! independent continuant range: BFO:0000003 ! occurrent [Typedef] id: RO:0002488 name: existence starts during def: "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." [] property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: RO:0002583 part_of is_a: existence_starts_during_or_after ! existence starts during or after is_a: RO:0002490 ! existence overlaps transitive_over: part_of ! part_of [Typedef] id: RO:0002490 name: existence overlaps def: "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002487 ! relation between physical entity and a process or stage [Typedef] id: RO:0002492 name: existence ends during def: "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: RO:0002593 part_of is_a: existence_ends_during_or_before ! existence ends during or before is_a: RO:0002490 ! existence overlaps transitive_over: part_of ! part_of [Typedef] id: RO:0002500 name: causal agent in process def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_a: RO:0002595 ! causal relation between material entity and a process inverse_of: RO:0002608 ! process has causal agent [Typedef] id: RO:0002501 name: causal relation between processes def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." [] property_value: curator_notes "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002502 name: depends on property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: seeAlso BFO:0000169 [Typedef] id: RO:0002503 name: towards def: "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" [] property_value: editor_note "This relation is provided in order to support the use of relational qualities such as 'concentration of'; for example, the concentration of C in V is a quality that inheres in V, but pertains to C." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 is_a: RO:0002502 ! depends on [Typedef] id: RO:0002506 name: causal relation between entities name: causal relation between material entities property_value: curator_notes "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string property_value: editor_note "The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations domain: BFO:0000002 ! continuant domain: BFO:0000040 ! material entity range: BFO:0000002 ! continuant range: BFO:0000040 ! material entity is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002559 name: causally influenced by property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "causally influenced by (entity-centric)" xsd:string property_value: IAO:0000589 "causally influenced by (material entity to material entity)" xsd:string is_a: RO:0002506 ! causal relation between material entities inverse_of: RO:0002566 ! causally influences [Typedef] id: RO:0002563 name: interaction relation helper property property_value: foaf-page https://github.com/oborel/obo-relations/wiki/InteractionRelations xsd:anyURI property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29 is_a: RO:0002464 ! helper property (not for use in curation) [Typedef] id: RO:0002564 name: molecular interaction relation helper property property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002563 ! interaction relation helper property [Typedef] id: RO:0002566 name: causally influences def: "Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b" [] def: "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Vasundra Touré" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "causally influences (entity-centric)" xsd:string property_value: IAO:0000589 "causally influences (material entity to material entity)" xsd:string domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: RO:0002506 ! causal relation between material entities [Typedef] id: RO:0002567 name: biomechanically related to def: "A relation that holds between elements of a musculoskeletal system or its analogs." [] property_value: curator_notes "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string domain: CARO:0000003 ! anatomical structure range: CARO:0000003 ! anatomical structure is_a: functionally_related_to ! functionally related to [Typedef] id: RO:0002573 name: has modifier def: "A relation that holds between an attribute or a qualifier and another attribute." [] subset: ro-eco property_value: curator_notes "This relation is intended to be used in combination with PATO, to be able to refine PATO quality classes using modifiers such as 'abnormal' and 'normal'. It has yet to be formally aligned into an ontological framework; it's not clear what the ontological status of the \"modifiers\" are." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 domain: BFO:0000020 ! specifically dependent continuant range: BFO:0000020 ! specifically dependent continuant [Typedef] id: RO:0002578 name: directly regulates def: "Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly regulates (processual)" xsd:string property_value: RO:0002575 RO:0002211 is_a: regulates ! regulates is_a: RO:0002412 ! immediately causally upstream of [Typedef] id: RO:0002583 name: existence starts at end of def: "holds between x and y if and only if the time point at which x starts is equivalent to the time point at which y ends. Formally: iff α(x) = ω(y)." [] is_a: existence_starts_during_or_after ! existence starts during or after [Typedef] id: RO:0002584 name: has part structure that is capable of def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" [] property_value: example_of_usage "gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: has_part capable_of is_a: functionally_related_to ! functionally related to is_a: RO:0002595 ! causal relation between material entity and a process [Typedef] id: RO:0002593 name: existence ends at start of def: "holds between x and y if and only if the time point at which x ends is equivalent to the time point at which y starts. Formally: iff ω(x) = α(y)." [] is_a: existence_ends_during_or_before ! existence ends during or before [Typedef] id: RO:0002595 name: causal relation between material entity and a process def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." [] property_value: editor_note "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations domain: BFO:0000040 ! material entity range: BFO:0000015 ! process is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002596 name: capable of regulating def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." [] property_value: example_of_usage "pyrethroid -> growth" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: capable_of regulates is_a: RO:0002500 ! causal agent in process [Typedef] id: RO:0002597 name: capable of negatively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: capable_of negatively_regulates is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0002598 name: capable of positively regulating def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." [] property_value: example_of_usage "renin -> arteriolar smooth muscle contraction" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations holds_over_chain: capable_of positively_regulates is_a: RO:0002596 ! capable of regulating [Typedef] id: RO:0002608 name: process has causal agent def: "Inverse of 'causal agent in process'" [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations is_a: RO:0002410 ! causally related to [Typedef] id: RO:0002609 name: obsolete related via dependence to def: "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." [] property_value: curator_notes "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect." xsd:string is_obsolete: true [Typedef] id: RO:0002629 name: directly positively regulates def: "Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2." [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly positively regulates (process to process)" xsd:string property_value: RO:0004049 RO:0002578 is_a: positively_regulates ! positively regulates is_a: RO:0002578 ! directly regulates [Typedef] id: RO:0002630 name: directly negatively regulates def: "Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2." [] property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "directly negatively regulates (process to process)" xsd:string property_value: RO:0004050 RO:0002578 is_a: negatively_regulates ! negatively regulates is_a: RO:0002578 ! directly regulates [Typedef] id: RO:0004029 name: disease has feature def: "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." [] domain: OGMS:0000031 ! disease is_a: RO:0040035 ! disease relationship created_by: cjm creation_date: 2017-12-26T19:50:53Z [Typedef] id: RO:0004031 name: enables subfunction def: "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." [] holds_over_chain: RO:0002327 has_part is_a: functionally_related_to ! functionally related to created_by: cjm creation_date: 2018-01-25T23:20:13Z [Typedef] id: RO:0004032 name: acts upstream of or within, positive effect property_value: RO:0004049 RO:0002264 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect holds_over_chain: RO:0002327 RO:0004047 is_a: RO:0002264 ! acts upstream of or within created_by: cjm creation_date: 2018-01-26T23:49:30Z [Typedef] id: RO:0004033 name: acts upstream of or within, negative effect property_value: RO:0004050 RO:0002264 holds_over_chain: RO:0002327 RO:0004046 is_a: RO:0002264 ! acts upstream of or within created_by: cjm creation_date: 2018-01-26T23:49:51Z [Typedef] id: RO:0004034 name: acts upstream of, positive effect def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" [] property_value: RO:0004049 RO:0002263 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect holds_over_chain: RO:0002327 RO:0002304 is_a: RO:0002263 ! acts upstream of is_a: RO:0004032 ! acts upstream of or within, positive effect created_by: cjm creation_date: 2018-01-26T23:53:14Z [Typedef] id: RO:0004035 name: acts upstream of, negative effect def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" [] property_value: RO:0004050 RO:0002263 property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect holds_over_chain: RO:0002327 RO:0002305 is_a: RO:0002263 ! acts upstream of is_a: RO:0004033 ! acts upstream of or within, negative effect created_by: cjm creation_date: 2018-01-26T23:53:22Z [Typedef] id: RO:0004046 name: causally upstream of or within, negative effect property_value: RO:0004050 RO:0002418 is_a: RO:0002418 ! causally upstream of or within created_by: cjm creation_date: 2018-03-13T23:55:05Z [Typedef] id: RO:0004047 name: causally upstream of or within, positive effect property_value: RO:0004049 RO:0002418 is_a: RO:0002418 ! causally upstream of or within created_by: cjm creation_date: 2018-03-13T23:55:19Z [Typedef] id: RO:0011002 name: regulates activity of def: "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." [] property_value: IAO:0000117 "Vasundra Touré" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002566 ! causally influences [Typedef] id: RO:0040035 name: disease relationship def: "This relation groups relations between diseases and any other kind of entity." [] property_value: curator_notes "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, in which the subject or object is a disease." xsd:string created_by: cjm creation_date: 2018-09-26T00:00:32Z [Typedef] id: adjacent_to name: adjacent to name: adjacent_to namespace: spatial namespace: uberon def: "x adjacent to y if and only if x and y share a boundary." [] def: "x adjacent_to y iff: x and y share a boundary" [] xref: RO:0002220 property_value: editor_note "This relation acts as a join point with BSPO" xsd:string property_value: example_of_usage "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"} property_value: example_of_usage "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string property_value: example_of_usage "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string property_value: example_of_usage "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0001900 RO:0001901 domain: BFO:0000004 ! independent continuant range: BFO:0000004 ! independent continuant is_symmetric: true is_a: RO:0002163 ! spatially disjoint from [Typedef] id: anterior_to name: anterior to name: anterior_to namespace: spatial namespace: uberon def: "x anterior to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail." [BSPO:cjm] def: "x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer" [http://orcid.org/0000-0002-6601-2165] synonym: "rostral_to" EXACT [] xref: BSPO:0000096 property_value: seeAlso FBcv:0000039 property_value: seeAlso FBql:00005863 is_transitive: true inverse_of: posterior_to ! posterior to created_by: cjm creation_date: 2009-07-31T02:15:46Z [Typedef] id: approximately_perpendicular_to name: approximately perpendicular to namespace: spatial def: "Crosses at an angle that is 90 degrees, or close to 90 degrees. In any non-linear organism, the main axes are rarely perpendicular when taken through the organism as a whole." [BSPO:cjm] xref: BSPO:0000104 domain: BSPO:0000010 ! anatomical axis range: BSPO:0000010 ! anatomical axis [Typedef] id: bearer_of name: bearer of namespace: uberon def: "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence" [] xref: RO:0000053 property_value: editor_note "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist." xsd:string property_value: example_of_usage "this apple is bearer of this red color" xsd:string property_value: example_of_usage "this vase is bearer of this fragility" xsd:string property_value: IAO:0000111 "bearer of" xsd:string property_value: IAO:0000118 "bearer_of" xsd:string property_value: IAO:0000118 "is bearer of" xsd:string property_value: RO:0001900 RO:0001901 range: BFO:0000020 ! specifically dependent continuant [Typedef] id: capable_of name: capable of namespace: uberon def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " [] subset: ro-eco xref: RO:0002215 property_value: curator_notes "For compatibility with BFO, this relation has a shortcut definition in which the expression \"capable of some P\" expands to \"bearer_of (some realized_by only P)\"." xsd:string property_value: example_of_usage "mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)" xsd:string property_value: example_of_usage "osteoclast SubClassOf 'capable of' some 'bone resorption'" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has function realized in" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20123131 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/21208450 domain: BFO:0000004 ! independent continuant range: BFO:0000015 ! process is_a: capable_of_part_of ! capable of part of is_a: functionally_related_to ! functionally related to expand_expression_to: "RO_0000053 some (RO_0000054 only ?Y)" [] [Typedef] id: capable_of_part_of name: capable of part of namespace: uberon def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." [] xref: RO:0002216 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has function in" xsd:string property_value: seeAlso "defining-property-chains-involving-reflexivity" holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: functionally_related_to ! functionally related to is_a: RO:0002500 ! causal agent in process expand_expression_to: "RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))" [] [Typedef] id: contains name: contains namespace: uberon subset: ro-eco xref: RO:0001019 property_value: IAO:0000111 "contains" xsd:string property_value: RO:0001900 RO:0001901 [Typedef] id: contains_process name: contains process namespace: uberon def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant xref: BFO:0000067 property_value: IAO:0000111 "site of" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Typedef] id: correlates_with name: correlates_with namespace: quality [Typedef] id: curator_notes name: curator note name: curator notes namespace: uberon def: "An administrative note of use for a curator but of no use for a user" [] xref: IAO:0000232 property_value: IAO:0000111 "curator note" xsd:string property_value: IAO:0000114 IAO:0000122 property_value: IAO:0000117 "PERSON:Alan Ruttenberg" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/iao.owl is_metadata_tag: true [Typedef] id: dc-contributor name: contributor namespace: uberon xref: http://purl.org/dc/elements/1.1/contributor is_metadata_tag: true [Typedef] id: dc-creator name: creator namespace: uberon xref: http://purl.org/dc/elements/1.1/creator is_metadata_tag: true [Typedef] id: dc-source name: derived from resource namespace: uberon xref: http://purl.org/dc/elements/1.1/source is_metadata_tag: true [Typedef] id: decreased_in_magnitude_relative_to name: decreased_in_magnitude_relative_to namespace: quality def: "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_transitive: true is_a: different_in_magnitude_relative_to ! different_in_magnitude_relative_to [Typedef] id: deep_to name: deep to name: deep_to namespace: spatial namespace: uberon def: "Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines." [BSPO:cjm] def: "Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines." [http://orcid.org/0000-0002-6601-2165] xref: BSPO:0000107 is_transitive: true inverse_of: superficial_to ! superficial_to [Typedef] id: depicted_by name: depicted by namespace: uberon xref: depicted:by is_metadata_tag: true [Typedef] id: developmentally_contributes_to name: developmentally contributes to name: developmentally_contributes_to namespace: uberon def: "inverse of has developmental contribution from" [] subset: RO:0002259 xref: RO:0002255 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: develops_into part_of is_a: has_potential_to_developmentally_contribute_to ! has potential to developmentally contribute to is_a: RO:0002286 ! developmentally succeeded by [Typedef] id: developmentally_preceded_by name: developmentally preceded by namespace: uberon def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" [] comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from xref: RO:0002258 property_value: curator_notes "In general you should not use this relation to make assertions - use one of the more specific relations below this one" xsd:string property_value: editor_note "false" xsd:boolean property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: RO:0002324 ! developmentally related to inverse_of: RO:0002286 ! developmentally succeeded by [Typedef] id: develops_from name: develops from name: develops_from namespace: uberon def: "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" [] comment: This is the transitive form of the develops from relation xref: RO:0002202 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000117 "Melissa Haendel" xsd:string property_value: IAO:0000117 "Terry Meehan" xsd:string domain: BFO:0000004 ! independent continuant range: BFO:0000004 ! independent continuant is_transitive: true is_a: developmentally_preceded_by ! developmentally preceded by is_a: has_developmental_contribution_from ! has developmental contribution from inverse_of: develops_into ! develops_into [Typedef] id: develops_into name: develops into name: develops_into namespace: uberon def: "inverse of develops from" [] subset: RO:0002259 xref: RO:0002203 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000117 "Terry Meehan" xsd:string is_transitive: true is_a: has_potential_to_develop_into ! has potential to develop into is_a: has_potential_to_directly_develop_into ! has potential to directly develop into is_a: RO:0002286 ! developmentally succeeded by [Typedef] id: different_in_magnitude_relative_to name: different_in_magnitude_relative_to namespace: quality def: "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] domain: PATO:0000001 ! quality range: PATO:0000001 ! quality [Typedef] id: dorsal_to name: dorsal to name: dorsal_to namespace: spatial namespace: uberon def: "x dorsal to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly)." [BSPO:cjm] def: "x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly)." [http://orcid.org/0000-0002-6601-2165] xref: BSPO:0000098 property_value: seeAlso FBcv:0000041 property_value: seeAlso FBql:00005865 is_transitive: true inverse_of: ventral_to ! ventral_to [Typedef] id: editor_note name: editor note namespace: uberon def: "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology." [] xref: IAO:0000116 property_value: IAO:0000111 "editor note" xsd:string property_value: IAO:0000114 IAO:0000122 property_value: IAO:0000117 "PERSON:Daniel Schober" xsd:string property_value: IAO:0000119 GROUP:OBI: xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/iao.owl is_metadata_tag: true [Typedef] id: ends_during name: ends during name: ends_during namespace: external comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). subset: ro-eco xref: RO:0002093 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "o" xsd:string property_value: IAO:0000118 "overlaps" xsd:string is_a: RO:0002222 ! temporally related to [Typedef] id: example_of_usage name: example of usage namespace: uberon xref: IAO:0000112 property_value: IAO:0000114 IAO:0000122 is_metadata_tag: true [Typedef] id: existence_ends_during_or_before name: existence ends during or before namespace: uberon def: "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. xref: RO:0002497 property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: part_of existence_ends_during_or_before holds_over_chain: RO:0002286 existence_ends_during_or_before is_a: RO:0002487 ! relation between physical entity and a process or stage transitive_over: part_of ! part_of transitive_over: precedes ! precedes transitive_over: RO:0002082 ! simultaneous with [Typedef] id: existence_starts_during_or_after name: existence starts during or after namespace: uberon def: "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." [] comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription. xref: RO:0002496 property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: developmentally_preceded_by existence_starts_during_or_after holds_over_chain: part_of existence_starts_during_or_after is_a: RO:0002487 ! relation between physical entity and a process or stage transitive_over: part_of ! part_of transitive_over: preceded_by ! preceded_by transitive_over: RO:0002082 ! simultaneous with [Typedef] id: external_definition name: external_definition namespace: uberon def: "An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class." [https://orcid.org/0000-0002-6601-2165] comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO xref: UBPROP:0000001 is_metadata_tag: true [Typedef] id: external_ontology_notes name: external_ontology_notes namespace: uberon def: "Notes on how similar or equivalent classes are represented in other ontologies." [https://orcid.org/0000-0002-6601-2165] xref: UBPROP:0000012 property_value: editor_note "This annotation property may be replaced with an annotation property from an external ontology such as IAO" xsd:string is_metadata_tag: true [Typedef] id: finishes_axis name: finishes axis namespace: spatial comment: A directional axis can be divided by a plane. Following Allen Interval Algebra terminology we say that the side on which the axis initiates starts the axis, with the other side finishing the axis. If s finishes axis x, and x has end point p, then x overlaps p xref: BSPO:0015001 domain: BSPO:0000054 ! anatomical side range: BSPO:0000010 ! anatomical axis [Typedef] id: foaf-page name: page namespace: uberon xref: http://xmlns.com/foaf/0.1/page is_metadata_tag: true [Typedef] id: functionally_related_to name: functionally related to namespace: uberon def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." [] xref: RO:0002328 property_value: curator_notes "This is a grouping relation that collects relations used for the purpose of connecting structure and function" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string [Typedef] id: happens_during name: happens during namespace: external comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) subset: ro-eco xref: RO:0002092 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "d" xsd:string property_value: IAO:0000118 "during" xsd:string is_transitive: true is_a: ends_during ! ends_during [Typedef] id: has_component name: has component namespace: uberon def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] subset: ro-eco xref: RO:0002180 property_value: curator_notes "For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit." xsd:string property_value: editor_note "The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity." xsd:string property_value: IAO:0000114 IAO:0000125 property_value: RO:0001900 RO:0001901 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:Componency is_a: has_part ! has part [Typedef] id: has_cross_section name: has_cross_section namespace: quality def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [PATOC:CJM] comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. [Typedef] id: has_developmental_contribution_from name: has developmental contribution from namespace: uberon def: "x has developmental contribution from y iff x has some part z such that z develops from y" [] xref: RO:0002254 property_value: example_of_usage "Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string domain: CARO:0000000 ! anatomical entity range: CARO:0000000 ! anatomical entity holds_over_chain: has_part develops_from is_a: developmentally_preceded_by ! developmentally preceded by inverse_of: developmentally_contributes_to ! developmentally contributes to [Typedef] id: has_part name: has part name: has_part namespace: external namespace: quality namespace: spatial namespace: uberon def: "a core relation that holds between a whole and its part" [] def: "Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2." [PATOC:CJM] comment: We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'. xref: BFO:0000051 property_value: editor_note "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." xsd:string property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: editor_note "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." xsd:string property_value: example_of_usage "my body has part my brain (continuant parthood, two material entities)" xsd:string property_value: example_of_usage "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)" xsd:string property_value: example_of_usage "this year has part this day (occurrent parthood)" xsd:string property_value: IAO:0000111 "has part" xsd:string property_value: IAO:0000118 "has_part" xsd:string property_value: RO:0001900 RO:0001901 is_transitive: true is_a: overlaps ! overlaps [Typedef] id: has_potential_to_develop_into name: has potential to develop into namespace: uberon def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" [] xref: RO:0002387 property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002384 ! has developmental potential involving [Typedef] id: has_potential_to_developmentally_contribute_to name: has potential to developmentally contribute to namespace: uberon def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" [] xref: RO:0002385 property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002384 ! has developmental potential involving [Typedef] id: has_potential_to_directly_develop_into name: has potential to directly develop into namespace: uberon def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" [] xref: RO:0002388 property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: has_potential_to_develop_into ! has potential to develop into [Typedef] id: has_relational_adjective name: has_relational_adjective namespace: uberon xref: UBPROP:0000007 property_value: curator_notes "Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'." xsd:string is_metadata_tag: true [Typedef] id: homology_notes name: homology_notes namespace: uberon def: "Notes on the homology status of this class." [https://orcid.org/0000-0002-6601-2165] comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO xref: UBPROP:0000003 is_metadata_tag: true [Typedef] id: immediately_deep_to name: immediately deep to name: immediately_deep_to namespace: spatial namespace: uberon def: "This relation holds when both the deep_to and ajdacent_to relationship similarly hold." [http://orcid.org/0000-0002-6601-2165] def: "x immediately deep to y iff x deep_to y and x is contiguous with y." [BSPO:curators] xref: BSPO:0001107 is_a: adjacent_to ! adjacent_to is_a: deep_to ! deep to inverse_of: immediately_superficial_to ! immediately superficial to [Typedef] id: immediately_preceded_by name: immediately preceded by name: immediately_preceded_by namespace: uberon def: "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)" [] comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) synonym: "directly preceded by" EXACT [] synonym: "is directly preceded by" EXACT [] synonym: "is immediately preceded by" EXACT [SIO:000251] synonym: "starts_at_end_of" EXACT [] xref: RO:0002087 property_value: external_definition "A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]." xsd:string {source="SIO:000251"} property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "starts_at_end_of" xsd:string property_value: seeAlso SIO:000251 holds_over_chain: RO:0002224 RO:0002230 is_a: preceded_by ! preceded_by inverse_of: RO:0002090 ! immediately precedes [Typedef] id: immediately_superficial_to name: immediately superficial to name: immediately_superficial_to namespace: spatial namespace: uberon def: "x immediately superficial to y iff x superficial to y and x is contiguous with y." [BSPO:curators] xref: BSPO:0015014 is_a: adjacent_to ! adjacent_to is_a: superficial_to ! superficial_to [Typedef] id: in_lateral_side_of name: in lateral side of name: in_lateral_side_of namespace: spatial namespace: uberon def: "X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure" [UBERON:cjm] def: "X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure" [https://orcid.org/0000-0002-6601-2165] xref: BSPO:0000126 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI is_a: part_of ! part_of [Typedef] id: increased_in_magnitude_relative_to name: increased_in_magnitude_relative_to namespace: quality def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_transitive: true is_a: different_in_magnitude_relative_to ! different_in_magnitude_relative_to [Typedef] id: input_of name: input of namespace: uberon def: "inverse of has input" [] subset: ro-eco subset: RO:0002259 xref: RO:0002352 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: functionally_related_to ! functionally related to is_a: RO:0000056 ! participates in [Typedef] id: ipsilateral_to name: ipsilateral to namespace: spatial def: "On the same side as. For example, the left arm is ipsilateral to the left leg." [BSPO:cjm] xref: BSPO:0000105 property_value: seeAlso FBql:00005850 is_symmetric: true is_a: in_lateral_side_of ! in lateral side of [Typedef] id: is_opposite_of name: is opposite of name: is_opposite_of namespace: quality def: "x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x)." [] xref: RO:0002604 property_value: example_of_usage "'anterior end of organism' is-opposite-of 'posterior end of organism'" xsd:string property_value: example_of_usage "'increase in temperature' is-opposite-of 'decrease in temperature'" xsd:string is_metadata_tag: true is_class_level: true [Typedef] id: negatively_regulates name: negatively regulates namespace: external def: "Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2." [] xref: RO:0002212 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "negatively regulates (process to process)" xsd:string property_value: RO:0004050 RO:0002211 holds_over_chain: RO:0002230 negatively_regulates is_a: regulates ! regulates is_a: RO:0002305 ! causally upstream of, negative effect inverse_of: RO:0002335 ! negatively regulated by [Typedef] id: occurs_in name: occurs in namespace: external def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant xref: BFO:0000066 property_value: IAO:0000111 "occurs in" xsd:string property_value: IAO:0000118 "occurs_in" xsd:string property_value: IAO:0000118 "unfolds in" xsd:string property_value: IAO:0000118 "unfolds_in" xsd:string property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl domain: BFO:0000003 ! occurrent range: BFO:0000004 ! independent continuant holds_over_chain: part_of occurs_in inverse_of: contains_process ! contains process transitive_over: part_of ! part_of [Typedef] id: opposite_to name: opposite to namespace: spatial def: "Direcly opposite to. i.e. on the opposite side through the axis." [BSPO:cjm] xref: BSPO:0000113 is_a: ipsilateral_to ! ipsilateral to [Typedef] id: orthogonal_to name: orthogonal to namespace: spatial def: "crossing at right angles" [BSPO:cjm] xref: BSPO:0015005 domain: BSPO:0000010 ! anatomical axis range: BSPO:0000400 ! anatomical plane [Typedef] id: overlaps name: overlaps namespace: spatial namespace: uberon def: "A overlaps B if they share some part in common." [] def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] def: "x overlaps y iff they have some part in common." [BSPO:cjm] comment: "(forall (x y) (iff (overlaps x y) (exists (z) (and (part of z x) (part of z y)))))" CLIF [] subset: ro-eco xref: RO:0002131 property_value: IAO:0000114 IAO:0000125 property_value: RO:0001900 RO:0001901 holds_over_chain: has_part overlaps holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} holds_over_chain: part_of part_of is_a: RO:0002323 ! mereotopologically related to transitive_over: part_of ! part_of expand_expression_to: "BFO_0000051 some (BFO_0000050 some ?Y)" [] expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" [] [Typedef] id: parallel_to name: parallel to namespace: spatial def: "x is parallel t y iff x and y are lines or planes which when extended indefinitely do not cross." [BSPO:curators] [Typedef] id: part_of name: part of name: part_of namespace: external namespace: quality namespace: spatial namespace: uberon def: "a core relation that holds between a part and its whole" [] xref: BFO:0000050 property_value: editor_note "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: editor_note "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: example_of_usage "my brain is part of my body (continuant parthood, two material entities)" xsd:string property_value: example_of_usage "my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)" xsd:string property_value: example_of_usage "this day is part of this year (occurrent parthood)" xsd:string property_value: IAO:0000111 "is part of" xsd:string property_value: IAO:0000118 "part_of" xsd:string property_value: RO:0001900 RO:0001901 property_value: RO:0040042 BFO:0000002 property_value: RO:0040042 BFO:0000003 property_value: RO:0040042 BFO:0000004 property_value: RO:0040042 BFO:0000017 property_value: RO:0040042 BFO:0000019 property_value: RO:0040042 BFO:0000020 property_value: RO:0040042 BFO:0000031 property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf property_value: seeAlso http://www.obofoundry.org/ro/#OBO_REL:part_of xsd:string is_transitive: true is_a: overlaps ! overlaps inverse_of: has_part ! has part [Typedef] id: part_of_structure_that_is_capable_of name: part of structure that is capable of namespace: uberon def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] xref: RO:0002329 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "false" xsd:boolean holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"} is_a: functionally_related_to ! functionally related to [Typedef] id: passes_through name: passes through namespace: spatial def: "Intersects at two points." [BSPO:cjm] xref: BSPO:0015006 domain: BSPO:0000010 ! anatomical axis [Typedef] id: positively_regulates name: positively regulates namespace: external def: "Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2." [] xref: RO:0002213 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "positively regulates (process to process)" xsd:string property_value: RO:0004049 RO:0002211 holds_over_chain: negatively_regulates negatively_regulates holds_over_chain: RO:0002230 positively_regulates is_transitive: true is_a: regulates ! regulates is_a: RO:0002304 ! causally upstream of, positive effect inverse_of: RO:0002336 ! positively regulated by [Typedef] id: posterior_to name: posterior to name: posterior_to namespace: spatial namespace: uberon def: "x posterior to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail." [BSPO:cjm] def: "x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail." [http://orcid.org/0000-0002-6601-2165] synonym: "caudal to" NARROW vertebrate [] synonym: "caudal_to" NARROW [] xref: BSPO:0000099 property_value: seeAlso FBcv:0000045 property_value: seeAlso FBql:00005864 is_transitive: true [Typedef] id: preceded_by name: preceded by name: preceded_by namespace: uberon def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] def: "X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)" [] subset: ro-eco synonym: "is preceded by" EXACT [SIO:000249] synonym: "takes place after" EXACT [Allen:precedes] xref: BFO:0000062 property_value: dc-source http://www.obofoundry.org/ro/#OBO_REL:preceded_by xsd:string property_value: editor_note "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string property_value: IAO:0000111 "preceded by" xsd:string property_value: IAO:0000118 "is preceded by" xsd:string property_value: IAO:0000118 "preceded_by" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: happens_during preceded_by holds_over_chain: part_of preceded_by holds_over_chain: starts_during preceded_by is_transitive: true is_a: RO:0002086 ! ends after inverse_of: precedes ! precedes [Typedef] id: precedes name: precedes namespace: uberon def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] subset: ro-eco xref: BFO:0000063 property_value: IAO:0000111 "precedes" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent holds_over_chain: happens_during precedes holds_over_chain: part_of precedes is_transitive: true is_a: RO:0002222 ! temporally related to [Typedef] id: produced_by name: produced by name: produced_by namespace: uberon def: "a produced_by b iff some process that occurs_in b has_output a." [] subset: ro-eco xref: RO:0003001 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Melissa Haendel" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity [Typedef] id: produces name: produces namespace: uberon def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." [] comment: Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue. subset: ro-eco xref: RO:0003000 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Melissa Haendel" xsd:string domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity inverse_of: produced_by ! produced_by [Typedef] id: reciprocal_of name: reciprocal_of namespace: quality def: "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." [PATOC:CJM] comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality. [Typedef] id: regulates name: regulates namespace: external def: "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2." [] xref: RO:0002211 property_value: curator_notes "Regulation precludes parthood; the regulatory process may not be within the regulated process." xsd:string property_value: editor_note "We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit" xsd:string property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "David Hill" xsd:string property_value: IAO:0000117 "Tanya Berardini" xsd:string property_value: IAO:0000119 "GO" xsd:string property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations property_value: IAO:0000589 "regulates (processual)" xsd:string property_value: IAO:0000600 "false" xsd:boolean domain: BFO:0000015 ! process range: BFO:0000015 ! process holds_over_chain: RO:0002230 regulates holds_over_chain: RO:0002578 RO:0002578 is_transitive: true is_a: RO:0002411 ! causally upstream of inverse_of: RO:0002334 ! regulated by [Typedef] id: specific_to name: specific_to def: "Restricted to domain" [] is_transitive: true [Typedef] id: starts_axis name: starts axis namespace: spatial comment: A directional axis can be divided by a plane. Following Allen Interval Algebra terminology we say that the side on which the axis initiates starts the axis, with the other side finishing the axis. . If s starts axis x, and x has start point p, then x overlaps p xref: BSPO:0015007 domain: BSPO:0000054 ! anatomical side range: BSPO:0000010 ! anatomical axis [Typedef] id: starts_during name: starts during name: starts_during namespace: external comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y)) subset: ro-eco xref: RO:0002091 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000118 "io" xsd:string domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent is_a: RO:0002222 ! temporally related to [Typedef] id: superficial_to name: superficial to name: superficial_to namespace: spatial namespace: uberon def: "Near the outer surface of the organism. Thus, skin is superficial to the muscle layer." [http://orcid.org/0000-0002-6601-2165] def: "Near the outer surface of the organism. Thus, skin is superficial to the muscle layer." [BSPO:cjm] xref: BSPO:0000108 is_transitive: true [Typedef] id: surface_of name: surface of namespace: spatial comment: placeholder. used for relation between anatomical surface and an anatomical side. xref: BSPO:0015008 domain: BSPO:0000005 ! anatomical surface [Typedef] id: taxon_notes name: taxon_notes namespace: uberon def: "Notes on the how instances of this class vary across species." [https://orcid.org/0000-0002-6601-2165] xref: UBPROP:0000008 is_metadata_tag: true [Typedef] id: ventral_to name: ventral to name: ventral_to namespace: spatial namespace: uberon def: "x ventral to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly)." [BSPO:cjm] def: "x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly)." [http://orcid.org/0000-0002-6601-2165] xref: BSPO:0000102 property_value: seeAlso FBcv:0000049 property_value: seeAlso FBql:00005866 is_transitive: true