format-version: 1.2
subsetdef: common_anatomy ""
subsetdef: efo_slim ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam ""
subsetdef: human_reference_atlas ""
subsetdef: pheno_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: uberon_slim ""
subsetdef: upper_level ""
subsetdef: vertebrate_core ""
default-namespace: relationship
ontology: ro/subsets/ro-chado.obo
property_value: http://purl.org/dc/terms/description "The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies." xsd:string
property_value: http://purl.org/dc/terms/license https://creativecommons.org/publicdomain/zero/1.0/
property_value: http://purl.org/dc/terms/title "OBO Relations Ontology" xsd:string
property_value: http://xmlns.com/foaf/0.1/homepage " https://github.com/oborel/obo-relations/" xsd:anyURI
property_value: owl:versionInfo "2024-02-13" xsd:string

[Typedef]
id: BFO:0000050
name: part_of
def: "a core relation that holds between a part and its whole" []
is_transitive: true
is_a: RO:0002131 ! overlaps
inverse_of: BFO:0000051 ! has part

[Typedef]
id: BFO:0000051
name: has_part
def: "a core relation that holds between a whole and its part" []
is_transitive: true
is_a: RO:0002131 ! overlaps

[Typedef]
id: BFO:0000054
name: realized_in
inverse_of: BFO:0000055 ! realizes

[Typedef]
id: BFO:0000055
name: realizes

[Typedef]
id: BFO:0000060
name: obsolete_preceded_by
is_transitive: true
is_obsolete: true

[Typedef]
id: BFO:0000062
name: preceded_by
def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
holds_over_chain: BFO:0000050 BFO:0000062
holds_over_chain: RO:0002091 BFO:0000062
holds_over_chain: RO:0002092 BFO:0000062
is_transitive: true
is_a: RO:0002086 ! ends after
inverse_of: BFO:0000063 ! precedes

[Typedef]
id: BFO:0000063
name: precedes
def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
holds_over_chain: BFO:0000050 BFO:0000063
holds_over_chain: RO:0002092 BFO:0000063
is_transitive: true
is_a: RO:0002222 ! temporally related to

[Typedef]
id: BFO:0000066
name: occurs_in
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
holds_over_chain: BFO:0000050 BFO:0000066
inverse_of: BFO:0000067 ! contains process
transitive_over: BFO:0000050 ! part of

[Typedef]
id: BFO:0000067
name: contains_process
def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []

[Typedef]
id: ENVO:01003004
name: derives_from_part_of
def: "A relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist through the separation or transformation of a part of the old entity, and the new entity inherits a significant portion of the matter belonging to that part of the old entity." []

[Typedef]
id: RO:0000052
name: characteristic_of
def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." []
is_functional: true
is_a: RO:0002314 ! characteristic of part of
inverse_of: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000053
name: has_characteristic
def: "Inverse of characteristic_of" []
is_inverse_functional: true

[Typedef]
id: RO:0000056
name: participates_in
def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" []
inverse_of: RO:0000057 ! has participant

[Typedef]
id: RO:0000057
name: has_participant
def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" []
holds_over_chain: BFO:0000051 RO:0000057

[Typedef]
id: RO:0000058
name: is_concretized_as
def: "A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants." []
inverse_of: RO:0000059 ! concretizes

[Typedef]
id: RO:0000059
name: concretizes
def: "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant." []

[Typedef]
id: RO:0000079
name: function_of
def: "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence" []
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000085 ! has function

[Typedef]
id: RO:0000080
name: quality_of
def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" []
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000086 ! has quality

[Typedef]
id: RO:0000081
name: role_of
def: "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence" []
is_a: RO:0000052 ! characteristic of
inverse_of: RO:0000087 ! has role

[Typedef]
id: RO:0000085
name: has_function
def: "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence" []
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000086
name: has_quality
def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" []
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000087
name: has_role
def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" []
is_a: RO:0000053 ! has characteristic

[Typedef]
id: RO:0000091
name: has_disposition
def: "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence" []
is_a: RO:0000053 ! has characteristic
inverse_of: RO:0000092 ! disposition of

[Typedef]
id: RO:0000092
name: disposition_of
def: "inverse of has disposition" []
is_a: RO:0000052 ! characteristic of

[Typedef]
id: RO:0000300
name: obsolete_in_neural_circuit_with
def: "OBSOLETE A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons." []
is_obsolete: true

[Typedef]
id: RO:0000301
name: obsolete_upstream_in_neural_circuit_with
def: "OBSOLETE A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next, in which the direction is from the last to the first." []
is_obsolete: true

[Typedef]
id: RO:0000302
name: obsolete_downstream_in_neural_circuit_with
def: "OBSOLETE A relation that holds between a neuron that is synapsed_by another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_by the next, in which the direction is from the last to the first." []
is_obsolete: true

[Typedef]
id: RO:0001000
name: derives_from
def: "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" []
inverse_of: RO:0001001 ! derives into

[Typedef]
id: RO:0001001
name: derives_into
def: "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" []

[Typedef]
id: RO:0001015
name: location_of
def: "a relation between two independent continuants, the location and the target, in which the target is entirely within the location" []
is_transitive: true
inverse_of: RO:0001025 ! located in

[Typedef]
id: RO:0001018
name: obsolete_contained_in
is_obsolete: true

[Typedef]
id: RO:0001019
name: obsolete_contains
is_obsolete: true

[Typedef]
id: RO:0001020
name: is_allergic_trigger_for
def: "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." []
is_a: RO:0003302 ! causes or contributes to condition
inverse_of: RO:0001022 ! has allergic trigger

[Typedef]
id: RO:0001021
name: is_autoimmune_trigger_for
def: "A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." []
is_a: RO:0003302 ! causes or contributes to condition
inverse_of: RO:0001023 ! has autoimmune trigger

[Typedef]
id: RO:0001022
name: has_allergic_trigger
def: "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." []
is_a: RO:0003302 ! causes or contributes to condition

[Typedef]
id: RO:0001023
name: has_autoimmune_trigger
def: "A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity." []
is_a: RO:0003302 ! causes or contributes to condition

[Typedef]
id: RO:0001025
name: located_in
def: "a relation between two independent continuants, the target and the location, in which the target is entirely within the location" []
is_transitive: true
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002000
name: 2D_boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
is_a: RO:0002323 ! mereotopologically related to
inverse_of: RO:0002002 ! has 2D boundary

[Typedef]
id: RO:0002001
name: aligned_with
is_transitive: true

[Typedef]
id: RO:0002002
name: has_2D_boundary
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002003
name: electrically_synapsed_to
def: "A relation that holds between two neurons that are electrically coupled via gap junctions." []
is_a: RO:0002170 ! connected to

[Typedef]
id: RO:0002004
name: tracheates
def: "The relationship that holds between a trachea or tracheole and an antomical structure that is contained in (and so provides an oxygen supply to)." []
is_a: RO:0001025 ! located in

[Typedef]
id: RO:0002005
name: innervated_by
inverse_of: RO:0002134 ! innervates

[Typedef]
id: RO:0002006
name: has_synaptic_terminal_of
is_a: RO:0002131 ! overlaps
inverse_of: RO:0002130 ! has synaptic terminal in

[Typedef]
id: RO:0002007
name: bounding_layer_of
def: "X outer_layer_of Y iff:\n. X :continuant that bearer_of some PATO:laminar\n. X part_of Y\n. exists Z :surface\n. X has_boundary Z\n. Z boundary_of Y\n\nhas_boundary: http://purl.obolibrary.org/obo/RO_0002002\nboundary_of: http://purl.obolibrary.org/obo/RO_0002000" []
is_a: BFO:0000050 ! part of

[Typedef]
id: RO:0002008
name: coincident_with
def: "A relation that holds between two linear structures that are approximately parallel to each other for their entire length and where either the two structures are adjacent to each other or one is part of the other." []
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002009
name: cell_expresses
def: "A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g." []
is_a: RO:0002292 ! expresses

[Typedef]
id: RO:0002010
name: regulates_in_another_organism
def: "x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." []
synonym: "regulates in other organism" EXACT []
is_a: RO:0002418 ! causally upstream of or within

[Typedef]
id: RO:0002011
name: regulates_transport_of
def: "A relationship that holds between a  process that regulates a transport process and the entity transported by that process." []
holds_over_chain: RO:0002211 RO:0002313

[Typedef]
id: RO:0002012
name: occurrent_part_of
def: "A part of relation that applies only between occurrents." []
is_a: BFO:0000050 ! part of
is_a: RO:0002418 ! causally upstream of or within

[Typedef]
id: RO:0002013
name: has_regulatory_component_activity
def: "A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B." []
is_a: RO:0002017 ! has component activity
is_a: RO:0002334 ! regulated by

[Typedef]
id: RO:0002014
name: has_negative_regulatory_component_activity
def: "A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B." []
is_a: RO:0002013 ! has regulatory component activity
is_a: RO:0002335 ! negatively regulated by

[Typedef]
id: RO:0002015
name: has_positive_regulatory_component_activity
def: "A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B." []
is_a: RO:0002013 ! has regulatory component activity
is_a: RO:0002336 ! positively regulated by

[Typedef]
id: RO:0002016
name: has_necessary_component_activity
is_a: RO:0002017 ! has component activity
is_a: RO:0002336 ! positively regulated by

[Typedef]
id: RO:0002017
name: has_component_activity
is_a: RO:0002018 ! has component process

[Typedef]
id: RO:0002018
name: has_component_process
def: "w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." []
is_a: RO:0002180 ! has component

[Typedef]
id: RO:0002019
name: has_ligand
def: "A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function." []
is_a: RO:0002233 ! has input

[Typedef]
id: RO:0002020
name: transports
def: "Holds between p and c when p is a transport process or transporter activity and the outcome of this p is to move c from one location to another." []
is_a: RO:0002313 ! transports or maintains localization of

[Typedef]
id: RO:0002021
name: occurs_across
def: "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." []
is_a: RO:0002479 ! has part that occurs in

[Typedef]
id: RO:0002022
name: directly_regulated_by
is_a: RO:0002334 ! regulated by
inverse_of: RO:0002578 ! directly regulates

[Typedef]
id: RO:0002023
name: directly_negatively_regulated_by
def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: RO:0002630 ! directly negatively regulates

[Typedef]
id: RO:0002024
name: directly_positively_regulated_by
def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: RO:0002629 ! directly positively regulates

[Typedef]
id: RO:0002025
name: has_effector_activity
def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity." [https://orcid.org/0000-0002-7073-9172]
is_functional: true
is_a: RO:0002017 ! has component activity

[Typedef]
id: RO:0002026
name: in_register_with
def: "A relationship that holds between two images, A and B, where:\nA depicts X;\nB depicts Y;\nX and Y are both of type T'\nC is a 2 layer image consiting of layers A and B;\nA and B are aligned in C according to a shared co-ordinate framework so that common features of X and Y are co-incident with each other.\nNote: A and B may be 2D or 3D.\nExamples include: the relationship between two channels collected simultaneously from a confocal microscope; the relationship between an image dpeicting X and a painted annotation layer that delineates regions of X; the relationship between the tracing of a neuron on an EM stack and the co-ordinate space of the stack; the relationship between two separately collected images that have been brought into register via some image registration software." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002081
name: before_or_simultaneous_with
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002082
name: simultaneous_with
def: "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time." []
is_symmetric: true
is_transitive: true
is_a: RO:0002081 ! before or simultaneous with

[Typedef]
id: RO:0002083
name: before
is_transitive: true
is_a: RO:0002081 ! before or simultaneous with

[Typedef]
id: RO:0002084
name: during_which_ends
is_a: RO:0002222 ! temporally related to
inverse_of: RO:0002093 ! ends during

[Typedef]
id: RO:0002085
name: encompasses
is_transitive: true
is_a: RO:0002088 ! during which starts
inverse_of: RO:0002092 ! happens during

[Typedef]
id: RO:0002086
name: ends_after
holds_over_chain: RO:0002093 BFO:0000062
is_transitive: true
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002087
name: immediately_preceded_by
holds_over_chain: RO:0002224 RO:0002230
is_a: BFO:0000062 ! preceded by
inverse_of: RO:0002090 ! immediately precedes

[Typedef]
id: RO:0002088
name: during_which_starts
is_a: RO:0002222 ! temporally related to
inverse_of: RO:0002091 ! starts during

[Typedef]
id: RO:0002089
name: starts_before
holds_over_chain: RO:0002091 BFO:0000060
is_transitive: true
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002090
name: immediately_precedes
holds_over_chain: RO:0002230 RO:0002224
is_a: BFO:0000063 ! precedes

[Typedef]
id: RO:0002091
name: starts_during
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002092
name: happens_during
is_transitive: true
is_a: RO:0002091 ! starts during
is_a: RO:0002093 ! ends during

[Typedef]
id: RO:0002093
name: ends_during
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002100
name: has_soma_location
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
is_a: RO:0002131 ! overlaps
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002101
name: fasciculates_with
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
is_a: RO:0002131 ! overlaps
inverse_of: RO:0002132 ! has fasciculating neuron projection

[Typedef]
id: RO:0002102
name: axon_synapses_in
def: "Relation between a neuron and some structure its axon forms (chemical) synapses in." []
is_a: RO:0002113 ! has presynaptic terminal in
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002103
name: synapsed_by
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to

[Typedef]
id: RO:0002104
name: has_plasma_membrane_part
def: "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." []
is_a: BFO:0000051 ! has part

[Typedef]
id: RO:0002105
name: synapsed_via_type_Ib_bouton_to
def: "A relation between a motor neuron and a muscle that it synapses to via a type Ib bouton." []
is_a: RO:0002120 ! synapsed to
inverse_of: RO:0002109 ! synapsed_by_via_type_Ib_bouton

[Typedef]
id: RO:0002106
name: synapsed_via_type_Is_bouton_to
def: "A relation between a motor neuron and a muscle that it synapses to via a type Is bouton." []
is_a: RO:0002120 ! synapsed to
inverse_of: RO:0002112 ! synapsed_by_via_type_Is_bouton

[Typedef]
id: RO:0002107
name: synapsed_via_type_II_bouton_to
def: "A relation between a motor neuron and a muscle that it synapses to via a type II bouton." []
is_a: RO:0002120 ! synapsed to
inverse_of: RO:0002108 ! synapsed_by_via_type_II_bouton

[Typedef]
id: RO:0002108
name: synapsed_by_via_type_II_bouton
def: "Relation between a muscle and a motor neuron that synapses to it via a type II bouton." []
is_a: RO:0002103 ! synapsed by

[Typedef]
id: RO:0002109
name: synapsed_by_via_type_Ib_bouton
def: "Relation between a muscle and a motor neuron that synapses to it via a type Ib bouton." []
is_a: RO:0002103 ! synapsed by

[Typedef]
id: RO:0002110
name: has_postsynaptic_terminal_in
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002111
name: releases_neurotransmitter

[Typedef]
id: RO:0002112
name: synapsed_by_via_type_Is_bouton
def: "Relation between a muscle and a motor neuron that synapses to it via a type Is bouton." []
is_a: RO:0002103 ! synapsed by

[Typedef]
id: RO:0002113
name: has_presynaptic_terminal_in
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002114
name: synapsed_via_type_III_bouton_to
def: "A relation between a motor neuron and a muscle that it synapses to via a type III bouton." []
is_a: RO:0002120 ! synapsed to
inverse_of: RO:0002115 ! synapsed_by_via_type_III_bouton

[Typedef]
id: RO:0002115
name: synapsed_by_via_type_III_bouton
def: "Relation between a muscle and a motor neuron that synapses to it via a type III bouton.\n" []
is_a: RO:0002103 ! synapsed by

[Typedef]
id: RO:0002120
name: synapsed_to
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n        " []
is_a: RO:0002486 ! sends output to

[Typedef]
id: RO:0002121
name: dendrite_synapsed_in
def: "Relation between a neuron and some structure  (e.g.- a brain region) in which its dendrite receives synaptic input.\n\n	" []
is_a: RO:0002110 ! has postsynaptic terminal in
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002130
name: has_synaptic_terminal_in
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
is_a: RO:0002131 ! overlaps
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002131
name: overlaps
def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" []
holds_over_chain: BFO:0000050 BFO:0000050
holds_over_chain: BFO:0000051 BFO:0000050 {RO:0002582="true"}
holds_over_chain: BFO:0000051 RO:0002131
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002132
name: has_fasciculating_neuron_projection
def: "The relation between a neuron projection bundle and a neuron projection that is fasciculated with it." []
is_a: RO:0002131 ! overlaps

[Typedef]
id: RO:0002134
name: innervates
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002150
name: continuous_with
def: "X continuous_with Y if and only if X and Y share a fiat boundary." []
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002151
name: partially_overlaps
def: "x partially overlaps y iff there exists some z such that z is part of x and z is part of y, and it is also the case that neither x is part of y or y is part of x" []
is_a: RO:0002131 ! overlaps

[Typedef]
id: RO:0002156
name: derived_by_descent_from
def: "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a." []
is_transitive: true
is_a: RO:0002320 ! evolutionarily related to
inverse_of: RO:0002157 ! has derived by descendant

[Typedef]
id: RO:0002157
name: has_derived_by_descendant
def: "inverse of derived by descent from" []
is_transitive: true
is_a: RO:0002320 ! evolutionarily related to

[Typedef]
id: RO:0002158
name: shares_ancestor_with
def: "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." []
holds_over_chain: RO:0002156 RO:0002157
is_symmetric: true
is_transitive: true
is_a: RO:0002320 ! evolutionarily related to

[Typedef]
id: RO:0002159
name: serially_homologous_to
is_symmetric: true
is_transitive: true
is_a: RO:0002320 ! evolutionarily related to

[Typedef]
id: RO:0002160
name: only_in_taxon
def: "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." []
is_a: RO:0002162 ! in taxon

[Typedef]
id: RO:0002162
name: in_taxon
def: "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." []
holds_over_chain: BFO:0000050 RO:0002162
holds_over_chain: BFO:0000051 RO:0002162
holds_over_chain: RO:0002202 RO:0002162
holds_over_chain: RO:0002206 RO:0002162
holds_over_chain: RO:0002214 RO:0002162
holds_over_chain: RO:0002215 RO:0002162
holds_over_chain: RO:0002225 RO:0002162
holds_over_chain: RO:0002254 RO:0002162
holds_over_chain: RO:0002295 RO:0002162
is_a: RO:0002320 ! evolutionarily related to

[Typedef]
id: RO:0002163
name: spatially_disjoint_from
def: "A is spatially_disjoint_from B if and only if they have no parts in common" []
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002170
name: connected_to
def: "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" []
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002176
name: connects
def: "c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system." []
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002177
name: attached_to_part_of
def: "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." []
holds_over_chain: RO:0002371 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to

[Typedef]
id: RO:0002178
name: supplies
def: "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." []
is_a: RO:0002170 ! connected to

[Typedef]
id: RO:0002179
name: drains
def: "Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure." []
is_a: RO:0002170 ! connected to

[Typedef]
id: RO:0002180
name: has_component
def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." []
is_a: BFO:0000051 ! has part

[Typedef]
id: RO:0002200
name: has_phenotype
def: "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." []
is_a: RO:0016001 ! has phenotype or disease
inverse_of: RO:0002201 ! phenotype of

[Typedef]
id: RO:0002201
name: phenotype_of
def: "inverse of has phenotype" []
is_functional: true

[Typedef]
id: RO:0002202
name: develops_from
def: "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" []
is_transitive: true
is_a: RO:0002254 ! has developmental contribution from
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002203 ! develops into

[Typedef]
id: RO:0002203
name: develops_into
def: "inverse of develops from" []
is_transitive: true
is_a: RO:0002286 ! developmentally succeeded by
is_a: RO:0002387 ! has potential to develop into
is_a: RO:0002388 ! has potential to directly develop into

[Typedef]
id: RO:0002204
name: gene_product_of
def: "definition \"x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from x\"" []
holds_over_chain: RO:0002512 RO:0002510
is_a: RO:0002330 ! genomically related to
inverse_of: RO:0002205 ! has gene product

[Typedef]
id: RO:0002205
name: has_gene_product
def: "x has gene product y if and only if x is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from y" []
holds_over_chain: RO:0002511 RO:0002513
is_a: RO:0002330 ! genomically related to

[Typedef]
id: RO:0002206
name: expressed_in
def: "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" []
is_a: RO:0002330 ! genomically related to
inverse_of: RO:0002292 ! expresses
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002207
name: directly_develops_from
def: "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." []
synonym: "has developmental precursor" EXACT []
is_a: RO:0002202 ! develops from
inverse_of: RO:0002210 ! directly develops into

[Typedef]
id: RO:0002208
name: parasitoid_of
def: "A parasite that kills or sterilizes its host" []
is_a: RO:0002444 ! parasite of
inverse_of: RO:0002209 ! has parasitoid

[Typedef]
id: RO:0002209
name: has_parasitoid
def: "inverse of parasitoid of" []
is_a: RO:0002445 ! parasitized by

[Typedef]
id: RO:0002210
name: directly_develops_into
def: "inverse of directly develops from" []
is_a: RO:0002203 ! develops into

[Typedef]
id: RO:0002211
name: regulates
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
holds_over_chain: RO:0002230 RO:0002211
holds_over_chain: RO:0002578 RO:0002578
is_transitive: true
is_a: RO:0002411 ! causally upstream of
inverse_of: RO:0002334 ! regulated by
transitive_over: RO:0002025 ! has effector activity

[Typedef]
id: RO:0002212
name: negatively_regulates
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
holds_over_chain: RO:0002230 RO:0002212
is_a: RO:0002211 ! regulates
is_a: RO:0002305 ! causally upstream of, negative effect
inverse_of: RO:0002335 ! negatively regulated by

[Typedef]
id: RO:0002213
name: positively_regulates
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
holds_over_chain: RO:0002212 RO:0002212
holds_over_chain: RO:0002230 RO:0002213
is_transitive: true
is_a: RO:0002211 ! regulates
is_a: RO:0002304 ! causally upstream of, positive effect
inverse_of: RO:0002336 ! positively regulated by

[Typedef]
id: RO:0002214
name: has_prototype
def: "x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a \"canonical\" heart, which participates in blood circulation." []

[Typedef]
id: RO:0002215
name: capable_of
def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " []
is_a: RO:0002216 ! capable of part of

[Typedef]
id: RO:0002216
name: capable_of_part_of
def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." []
holds_over_chain: RO:0002215 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002328 ! functionally related to
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002217
name: obsolete_actively_participates_in
def: "OBSOLETE x actively participates in y if and only if x participates in y and x realizes some active role" []
is_obsolete: true
replaced_by: RO:0002608

[Typedef]
id: RO:0002218
name: obsolete_has_active_participant
def: "OBSOLETE x has participant y if and only if x realizes some active role that inheres in y" []
is_obsolete: true
replaced_by: RO:0002500

[Typedef]
id: RO:0002219
name: surrounded_by
def: "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" []
is_a: RO:0002220 ! adjacent to
inverse_of: RO:0002221 ! surrounds

[Typedef]
id: RO:0002220
name: adjacent_to
def: "x adjacent to y if and only if x and y share a boundary." []
is_a: RO:0002163 ! spatially disjoint from

[Typedef]
id: RO:0002221
name: surrounds
def: "inverse of surrounded by" []
is_a: RO:0002220 ! adjacent to

[Typedef]
id: RO:0002222
name: temporally_related_to

[Typedef]
id: RO:0002223
name: starts
def: "inverse of starts with" []
is_a: BFO:0000050 ! part of
is_a: RO:0002222 ! temporally related to
inverse_of: RO:0002224 ! starts with

[Typedef]
id: RO:0002224
name: starts_with
def: "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
is_transitive: true
is_a: BFO:0000051 ! has part
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002225
name: develops_from_part_of
def: "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" []
holds_over_chain: RO:0002207 BFO:0000050
is_a: RO:0002202 ! develops from

[Typedef]
id: RO:0002226
name: develops_in
def: "x develops_in y if x is located in y whilst x is developing" []
holds_over_chain: RO:0002207 RO:0001025
is_a: RO:0002258 ! developmentally preceded by

[Typedef]
id: RO:0002227
name: obligate_parasite_of
def: "A sub-relation of parasite-of in which the parasite that cannot complete its life cycle without a host." []
is_a: RO:0002444 ! parasite of

[Typedef]
id: RO:0002228
name: facultative_parasite_of
def: "A sub-relations of parasite-of in which the parasite that can complete its life cycle independent of a host." []
is_a: RO:0002444 ! parasite of

[Typedef]
id: RO:0002229
name: ends
def: "inverse of ends with" []
is_a: BFO:0000050 ! part of
is_a: RO:0002222 ! temporally related to
inverse_of: RO:0002230 ! ends with

[Typedef]
id: RO:0002230
name: ends_with
def: "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." []
is_transitive: true
is_a: BFO:0000051 ! has part
is_a: RO:0002222 ! temporally related to

[Typedef]
id: RO:0002231
name: has_start_location
def: "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" []
holds_over_chain: RO:0002224 BFO:0000066
is_a: RO:0002479 ! has part that occurs in

[Typedef]
id: RO:0002232
name: has_end_location
def: "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" []
holds_over_chain: RO:0002230 BFO:0000066
is_a: RO:0002479 ! has part that occurs in

[Typedef]
id: RO:0002233
name: has_input
def: "p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p." []
holds_over_chain: RO:0002224 RO:0002233
is_a: RO:0000057 ! has participant
inverse_of: RO:0002352 ! input of

[Typedef]
id: RO:0002234
name: has_output
def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." []
holds_over_chain: RO:0002230 RO:0002234
is_a: RO:0000057 ! has participant
inverse_of: RO:0002353 ! output of

[Typedef]
id: RO:0002235
name: stem_parasite_of
def: "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host stem (PO:0009047)" []
is_a: RO:0002444 ! parasite of

[Typedef]
id: RO:0002236
name: root_parasite_of
def: "A parasite-of relationship in which the host is a plant and the parasite that attaches to the host root (PO:0009005)" []
is_a: RO:0002444 ! parasite of

[Typedef]
id: RO:0002237
name: hemiparasite_of
def: "A sub-relation of parasite-of in which the parasite is a plant, and the parasite is parasitic under natural conditions and is also photosynthetic to some degree. Hemiparasites may just obtain water and mineral nutrients from the host plant. Many obtain at least part of their organic nutrients from the host as well." []
is_a: RO:0002444 ! parasite of

[Typedef]
id: RO:0002238
name: has_component_participant
def: "X 'has component participant' Y means X 'has participant' Y and there is a cardinality constraint that specifies the numbers of Ys." []
is_a: RO:0000057 ! has participant

[Typedef]
id: RO:0002240
name: has_exposure_receptor
def: "A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event." []
is_a: RO:0002244 ! related via exposure to

[Typedef]
id: RO:0002241
name: has_exposure_stressor
def: "A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event." []
is_a: RO:0002309 ! has exposure stimulus

[Typedef]
id: RO:0002242
name: has_exposure_route
def: "A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor" []
is_a: RO:0002244 ! related via exposure to

[Typedef]
id: RO:0002243
name: has_exposure_transport_path
def: "A broad relationship between an exposure event or process and the course takes from the source to the target." []
is_a: RO:0002244 ! related via exposure to

[Typedef]
id: RO:0002244
name: related_via_exposure_to
def: "Any relationship between an exposure event or process and any other entity." []
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002245
name: over-expressed_in
def: "g is over-expressed in t iff g is expressed in t, and the expression level of g is increased relative to some background." []
is_a: RO:0002206 ! expressed in

[Typedef]
id: RO:0002246
name: under-expressed_in
def: "g is under-expressed in t iff g is expressed in t, and the expression level of g is decreased relative to some background." []
is_a: RO:0002206 ! expressed in

[Typedef]
id: RO:0002248
name: has_active_ingredient
def: "A relationship that holds between a substance and a chemical entity, if the chemical entity is part of the substance, and the chemical entity forms the biologically active component of the substance." []
synonym: "has active pharmaceutical ingredient" RELATED []
synonym: "has active substance" EXACT []
is_a: BFO:0000051 ! has part
inverse_of: RO:0002249 ! active ingredient in

[Typedef]
id: RO:0002249
name: active_ingredient_in
def: "inverse of has active ingredient" []
is_a: BFO:0000050 ! part of

[Typedef]
id: RO:0002252
name: connecting_branch_of
def: "b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t." []
is_a: RO:0002170 ! connected to
is_a: RO:0002375 ! in branching relationship with
inverse_of: RO:0002253 ! has connecting branch

[Typedef]
id: RO:0002253
name: has_connecting_branch
def: "inverse of connecting branch of" []
is_a: RO:0002375 ! in branching relationship with

[Typedef]
id: RO:0002254
name: has_developmental_contribution_from
def: "x has developmental contribution from y iff x has some part z such that z develops from y" []
holds_over_chain: BFO:0000051 RO:0002202
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002255 ! developmentally contributes to

[Typedef]
id: RO:0002255
name: developmentally_contributes_to
def: "inverse of has developmental contribution from" []
holds_over_chain: RO:0002203 BFO:0000050
is_a: RO:0002286 ! developmentally succeeded by
is_a: RO:0002385 ! has potential to developmentally contribute to

[Typedef]
id: RO:0002256
name: developmentally_induced_by
def: "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T" []
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002257 ! developmentally induces

[Typedef]
id: RO:0002257
name: developmentally_induces
def: "Inverse of developmentally induced by" []
is_a: RO:0002286 ! developmentally succeeded by
is_a: RO:0002386 ! has potential to developmentally induce

[Typedef]
id: RO:0002258
name: developmentally_preceded_by
def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" []
is_a: RO:0002324 ! developmentally related to
inverse_of: RO:0002286 ! developmentally succeeded by

[Typedef]
id: RO:0002260
name: has_biological_role
def: "c has-biological-role r iff c has-role r and r is a biological role (CHEBI:24432)" []
is_a: RO:0000087 ! has role

[Typedef]
id: RO:0002261
name: has_application_role
def: "c has-application-role r iff c has-role r and r is an application role (CHEBI:33232)" []
is_a: RO:0000087 ! has role

[Typedef]
id: RO:0002262
name: has_chemical_role
def: "c has-chemical-role r iff c has-role r and r is a chemical role (CHEBI:51086)" []
is_a: RO:0000087 ! has role

[Typedef]
id: RO:0002263
name: acts_upstream_of
def: "c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes." []
holds_over_chain: RO:0002327 RO:0002411
is_a: RO:0002264 ! acts upstream of or within

[Typedef]
id: RO:0002264
name: acts_upstream_of_or_within
def: "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." []
synonym: "affects" RELATED []
holds_over_chain: RO:0002327 RO:0002418
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002285
name: developmentally_replaces
def: "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" []
is_a: RO:0002258 ! developmentally preceded by

[Typedef]
id: RO:0002286
name: developmentally_succeeded_by
def: "Inverse of developmentally preceded by" []
is_a: RO:0002384 ! has developmental potential involving

[Typedef]
id: RO:0002287
name: part_of_developmental_precursor_of
holds_over_chain: BFO:0000050 RO:0002210
is_a: RO:0002286 ! developmentally succeeded by

[Typedef]
id: RO:0002291
name: ubiquitously_expressed_in
def: "x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x" []
is_a: RO:0002206 ! expressed in
inverse_of: RO:0002293 ! ubiquitously expresses

[Typedef]
id: RO:0002292
name: expresses
def: "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process." []
is_a: RO:0002330 ! genomically related to

[Typedef]
id: RO:0002293
name: ubiquitously_expresses
def: "inverse of ubiquiotously expressed in" []
is_a: RO:0002292 ! expresses

[Typedef]
id: RO:0002295
name: results_in_developmental_progression_of
def: "p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." []
is_a: RO:0002324 ! developmentally related to

[Typedef]
id: RO:0002296
name: results_in_development_of
def: "p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state." []
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002297
name: results_in_formation_of_anatomical_entity
is_a: RO:0002234 ! has output
is_a: RO:0002295 ! results in developmental progression of
inverse_of: RO:0002354 ! formed as result of

[Typedef]
id: RO:0002298
name: results_in_morphogenesis_of
def: "The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state." []
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002299
name: results_in_maturation_of
def: "The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity." []
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002300
name: results_in_disappearance_of
is_a: RO:0002552 ! results in ending of

[Typedef]
id: RO:0002301
name: results_in_developmental_regression_of
is_a: RO:0002552 ! results in ending of

[Typedef]
id: RO:0002302
name: is_treated_by_substance
def: "Inverse of 'is substance that treats'" []
is_a: RO:0002410 ! causally related to
inverse_of: RO:0002606 ! is substance that treats

[Typedef]
id: RO:0002303
name: has_habitat
def: "x 'has habitat' y if and only if: x is an organism, y is a habitat, and y can sustain and allow the growth of a population of xs." []
is_a: RO:0002321 ! ecologically related to

[Typedef]
id: RO:0002304
name: causally_upstream_of,_positive_effect
def: "p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q." []
is_a: RO:0002411 ! causally upstream of
is_a: RO:0004047 ! causally upstream of or within, positive effect

[Typedef]
id: RO:0002305
name: causally_upstream_of,_negative_effect
def: "p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q." []
is_a: RO:0002411 ! causally upstream of
is_a: RO:0004046 ! causally upstream of or within, negative effect

[Typedef]
id: RO:0002309
name: has_exposure_stimulus
def: "A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event." []
is_a: RO:0002244 ! related via exposure to

[Typedef]
id: RO:0002312
name: evolutionary_variant_of
is_a: RO:0002320 ! evolutionarily related to

[Typedef]
id: RO:0002313
name: transports_or_maintains_localization_of
def: "Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment)  and the outcome of this process is to regulate the localization of c." []
is_a: RO:0002337 ! related via localization to
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002314
name: characteristic_of_part_of
def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." []
holds_over_chain: RO:0000052 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002315
name: results_in_acquisition_of_features_of
def: "The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity" []
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002320
name: evolutionarily_related_to
def: "A relationship that holds via some environmental process" []

[Typedef]
id: RO:0002321
name: ecologically_related_to
def: "A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)" []

[Typedef]
id: RO:0002322
name: confers_advantage_in
is_a: RO:0002321 ! ecologically related to

[Typedef]
id: RO:0002323
name: mereotopologically_related_to
def: "A mereological relationship or a topological relationship" []

[Typedef]
id: RO:0002324
name: developmentally_related_to
def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" []

[Typedef]
id: RO:0002325
name: colocalizes_with
def: "a colocalizes_with b if and only if  a is transiently or peripherally associated with b[GO]." []
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002326
name: contributes_to
is_a: RO:0002216 ! capable of part of
is_a: RO:0002329 ! part of structure that is capable of

[Typedef]
id: RO:0002327
name: enables
def: "c enables p iff c is capable of p and c acts to execute p." []
is_a: RO:0002215 ! capable of
inverse_of: RO:0002333 ! enabled by
transitive_over: BFO:0000051 ! has part
transitive_over: RO:0002017 ! has component activity

[Typedef]
id: RO:0002328
name: functionally_related_to
def: "A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities." []

[Typedef]
id: RO:0002329
name: part_of_structure_that_is_capable_of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
holds_over_chain: BFO:0000050 RO:0002215 {RO:0002581="true"}
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002330
name: genomically_related_to
def: "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." []

[Typedef]
id: RO:0002331
name: involved_in
def: "c involved_in p if and only if c enables some process p', and p' is part of p" []
holds_over_chain: RO:0002327 BFO:0000050
is_a: RO:0000056 ! participates in
is_a: RO:0002431 ! involved in or involved in regulation of
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002332
name: regulates_levels_of
def: "p regulates levels of c if p regulates some amount (PATO:0000070) of c" []
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002333
name: enabled_by
def: "inverse of enables" []
is_a: RO:0000057 ! has participant
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002334
name: regulated_by
def: "inverse of regulates" []
is_transitive: true
is_a: RO:0002427 ! causally downstream of or within

[Typedef]
id: RO:0002335
name: negatively_regulated_by
def: "inverse of negatively regulates" []
is_a: RO:0002334 ! regulated by

[Typedef]
id: RO:0002336
name: positively_regulated_by
def: "inverse of positively regulates" []
is_a: RO:0002334 ! regulated by

[Typedef]
id: RO:0002337
name: related_via_localization_to
def: "A relationship that holds via some process of localization" []

[Typedef]
id: RO:0002338
name: has_target_start_location
def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." []
is_a: RO:0002344 ! results in transport to from or in
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002339
name: has_target_end_location
def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." []
is_a: RO:0002344 ! results in transport to from or in
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002340
name: imports
def: "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s." []
is_a: RO:0002020 ! transports

[Typedef]
id: RO:0002341
name: results_in_transport_along
def: "Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l " []
is_a: RO:0002337 ! related via localization to

[Typedef]
id: RO:0002342
name: results_in_transport_across
def: "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." []
is_a: RO:0002021 ! occurs across
is_a: RO:0002344 ! results in transport to from or in

[Typedef]
id: RO:0002343
name: results_in_growth_of
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002344
name: results_in_transport_to_from_or_in
is_a: RO:0002337 ! related via localization to

[Typedef]
id: RO:0002345
name: exports
def: "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the end location of c is part of the region that surrounds s." []
is_a: RO:0002020 ! transports

[Typedef]
id: RO:0002348
name: results_in_commitment_to
def: "p 'results in commitment to' c if and only if p is a developmental process and c is a cell and p results in the state of c changing such that is can only develop into a single cell type." []
is_a: RO:0002295 ! results in developmental progression of

[Typedef]
id: RO:0002349
name: results_in_determination_of
def: "p 'results in determination of' c if and only if p is a developmental process and c is a cell and p results in the state of c changing to be determined. Once a cell becomes determined, it becomes committed to differentiate down a particular pathway regardless of its environment." []
is_a: RO:0002295 ! results in developmental progression of

[Typedef]
id: RO:0002350
name: member_of
def: "is member of is a mereological relation between a item and a collection." []
is_a: BFO:0000050 ! part of
inverse_of: RO:0002351 ! has member

[Typedef]
id: RO:0002351
name: has_member
def: "has member is a mereological relation between a collection and an item." []
is_a: BFO:0000051 ! has part

[Typedef]
id: RO:0002352
name: input_of
def: "inverse of has input" []
is_a: RO:0000056 ! participates in
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002353
name: output_of
def: "inverse of has output" []
is_a: RO:0000056 ! participates in
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002354
name: formed_as_result_of
is_a: RO:0002353 ! output of

[Typedef]
id: RO:0002355
name: results_in_structural_organization_of
def: "A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity." []
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002356
name: results_in_specification_of
def: "The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. " []
is_a: RO:0002295 ! results in developmental progression of

[Typedef]
id: RO:0002357
name: results_in_developmental_induction_of
def: "p results in developmental induction of c if and only if p is a collection of cell-cell signaling processes that signal to a neighbouring tissue that is the precursor of the mature c, where the signaling results in the commitment to cell types necessary for the formation of c." []
is_a: RO:0002295 ! results in developmental progression of

[Typedef]
id: RO:0002360
name: has_dendrite_location
is_a: RO:0002131 ! overlaps

[Typedef]
id: RO:0002371
name: attached_to
def: "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" []
is_symmetric: true
is_a: RO:0002170 ! connected to
is_a: RO:0002177 ! attached to part of

[Typedef]
id: RO:0002372
name: has_muscle_origin
def: "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to." []
is_a: RO:0002371 ! attached to
is_a: RO:0002567 ! biomechanically related to

[Typedef]
id: RO:0002373
name: has_muscle_insertion
def: "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone." []
is_a: RO:0002371 ! attached to
is_a: RO:0002567 ! biomechanically related to

[Typedef]
id: RO:0002374
name: derived_from_ancestral_fusion_of
def: "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat" []
synonym: "has fused element" BROAD []
is_a: RO:0002156 ! derived by descent from

[Typedef]
id: RO:0002375
name: in_branching_relationship_with
def: "A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network." []
is_a: RO:0002323 ! mereotopologically related to

[Typedef]
id: RO:0002376
name: tributary_of
def: "x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein." []
is_a: RO:0002170 ! connected to
is_a: RO:0002375 ! in branching relationship with

[Typedef]
id: RO:0002377
name: distributary_of
def: "x distributary_of y if and only if x is capable of channeling the flow of a substance to y, where y channels less of the substance than x" []
is_a: RO:0002170 ! connected to
is_a: RO:0002375 ! in branching relationship with

[Typedef]
id: RO:0002378
name: anabranch_of
def: "x anabranch_of y if x is a distributary of y (i.e. it channels a from a larger flow from y) and x ultimately channels the flow back into y." []
is_a: RO:0002377 ! distributary of
disjoint_from: RO:0002382 ! proper distributary of
disjoint_from: RO:0002383 ! proper tributary of

[Typedef]
id: RO:0002379
name: spatially_coextensive_with
def: "x spatially_coextensive_with y if and inly if x and y have the same location" []
is_a: RO:0002131 ! overlaps

[Typedef]
id: RO:0002380
name: branching_part_of
def: "x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y" []
holds_over_chain: RO:0002377 RO:0002381
is_a: BFO:0000050 ! part of
is_a: RO:0002375 ! in branching relationship with
inverse_of: RO:0002569 ! has branching part

[Typedef]
id: RO:0002381
name: main_stem_of
def: "x main_stem_of y if y is a branching structure and x is a channel that traces a linear path through y, such that x has higher capacity than any other such path." []
is_a: BFO:0000050 ! part of
is_a: RO:0002375 ! in branching relationship with

[Typedef]
id: RO:0002382
name: proper_distributary_of
def: "x proper_distributary_of y iff x distributary_of y and x does not flow back into y" []
is_a: RO:0002377 ! distributary of

[Typedef]
id: RO:0002383
name: proper_tributary_of
def: "x proper_tributary_of y iff x tributary_of y and x does not originate from y" []
is_a: RO:0002376 ! tributary of

[Typedef]
id: RO:0002384
name: has_developmental_potential_involving
def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." []
is_a: RO:0002324 ! developmentally related to

[Typedef]
id: RO:0002385
name: has_potential_to_developmentally_contribute_to
def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" []
is_a: RO:0002384 ! has developmental potential involving

[Typedef]
id: RO:0002386
name: has_potential_to_developmentally_induce
def: "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y" []
is_a: RO:0002384 ! has developmental potential involving

[Typedef]
id: RO:0002387
name: has_potential_to_develop_into
def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" []
is_a: RO:0002384 ! has developmental potential involving

[Typedef]
id: RO:0002388
name: has_potential_to_directly_develop_into
def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" []
is_a: RO:0002387 ! has potential to develop into

[Typedef]
id: RO:0002400
name: has_direct_input
def: "p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p." []
holds_over_chain: RO:0002224 RO:0002400
is_a: RO:0002233 ! has input

[Typedef]
id: RO:0002401
name: obsolete_has_indirect_input
is_obsolete: true

[Typedef]
id: RO:0002402
name: obsolete_has_direct_output
def: "p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. " []
is_obsolete: true

[Typedef]
id: RO:0002403
name: obsolete_has_indirect_output
holds_over_chain: RO:0002411 RO:0002402
is_obsolete: true

[Typedef]
id: RO:0002404
name: causally_downstream_of
def: "inverse of upstream of" []
is_a: BFO:0000062 ! preceded by
is_a: RO:0002427 ! causally downstream of or within
inverse_of: RO:0002411 ! causally upstream of

[Typedef]
id: RO:0002405
name: immediately_causally_downstream_of
is_a: RO:0002087 ! immediately preceded by
is_a: RO:0002404 ! causally downstream of
inverse_of: RO:0002412 ! immediately causally upstream of

[Typedef]
id: RO:0002406
name: obsolete_directly_activates
is_obsolete: true
replaced_by: RO:0002629

[Typedef]
id: RO:0002407
name: indirectly_positively_regulates
def: "p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q." []
holds_over_chain: RO:0002409 RO:0002409
holds_over_chain: RO:0002629 RO:0002407
holds_over_chain: RO:0002629 RO:0002629
is_transitive: true
is_a: RO:0002213 ! positively regulates
is_a: RO:0012012 ! indirectly regulates
transitive_over: RO:0002629 ! directly positively regulates

[Typedef]
id: RO:0002408
name: obsolete_directly_inhibits
is_obsolete: true
replaced_by: RO:0002630

[Typedef]
id: RO:0002409
name: indirectly_negatively_regulates
def: "p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q." []
holds_over_chain: RO:0002630 RO:0002409
holds_over_chain: RO:0002630 RO:0002630
is_transitive: true
is_a: RO:0002212 ! negatively regulates
is_a: RO:0012012 ! indirectly regulates
transitive_over: RO:0002630 ! directly negatively regulates

[Typedef]
id: RO:0002410
name: causally_related_to
def: "relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause." [https://en.wikipedia.org/wiki/Causality]

[Typedef]
id: RO:0002411
name: causally_upstream_of
def: "p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q." []
is_transitive: true
is_a: BFO:0000063 ! precedes
is_a: RO:0002418 ! causally upstream of or within

[Typedef]
id: RO:0002412
name: immediately_causally_upstream_of
def: "p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q." []
is_a: RO:0002090 ! immediately precedes
is_a: RO:0002411 ! causally upstream of

[Typedef]
id: RO:0002413
name: provides_input_for
def: "p provides input for q iff p is immediately causally upstream of q, and there exists some c such that p has_output c and q has_input c." []
holds_over_chain: RO:0002402 RO:0002400
is_a: RO:0002412 ! immediately causally upstream of
is_a: RO:0002414 ! transitively provides input for

[Typedef]
id: RO:0002414
name: transitively_provides_input_for
def: "transitive form of directly_provides_input_for" []
is_transitive: true
is_a: RO:0004047 ! causally upstream of or within, positive effect

[Typedef]
id: RO:0002418
name: causally_upstream_of_or_within
def: "p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q." []
synonym: "affects" RELATED []
is_transitive: true
is_a: RO:0002501 ! causal relation between processes
inverse_of: RO:0002427 ! causally downstream of or within

[Typedef]
id: RO:0002424
name: differs_in

[Typedef]
id: RO:0002425
name: differs_in_attribute_of
is_a: RO:0002424 ! differs in

[Typedef]
id: RO:0002426
name: differs_in_attribute
is_a: RO:0002424 ! differs in

[Typedef]
id: RO:0002427
name: causally_downstream_of_or_within
def: "inverse of causally upstream of or within" []
is_transitive: true
is_a: RO:0002501 ! causal relation between processes

[Typedef]
id: RO:0002428
name: involved_in_regulation_of
def: "c involved in regulation of p if c is involved in some p' and p' regulates some p" []
holds_over_chain: RO:0002327 RO:0002211
holds_over_chain: RO:0002331 RO:0002211
is_a: RO:0002263 ! acts upstream of
is_a: RO:0002431 ! involved in or involved in regulation of

[Typedef]
id: RO:0002429
name: involved_in_positive_regulation_of
def: "c involved in regulation of p if c is involved in some p' and p' positively regulates some p" []
holds_over_chain: RO:0002327 RO:0002213
holds_over_chain: RO:0002331 RO:0002213
is_a: RO:0002428 ! involved in regulation of

[Typedef]
id: RO:0002430
name: involved_in_negative_regulation_of
def: "c involved in regulation of p if c is involved in some p' and p' negatively regulates some p" []
holds_over_chain: RO:0002327 RO:0002212
holds_over_chain: RO:0002331 RO:0002212
is_a: RO:0002428 ! involved in regulation of

[Typedef]
id: RO:0002431
name: involved_in_or_involved_in_regulation_of
def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" []
is_a: RO:0002264 ! acts upstream of or within
is_a: RO:0002328 ! functionally related to
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002432
name: is_active_in
def: "c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-7073-9172]
synonym: "enables activity in" EXACT []
holds_over_chain: RO:0002327 BFO:0000066 {RO:0002581="true"}
is_a: RO:0002131 ! overlaps
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002433
name: contributes_to_morphology_of
def: "p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm." []
is_a: RO:0002131 ! overlaps

[Typedef]
id: RO:0002434
name: interacts_with
def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." []
synonym: "in pairwise interaction with" EXACT []
is_symmetric: true

[Typedef]
id: RO:0002435
name: genetically_interacts_with
is_symmetric: true
is_a: RO:0002434 ! interacts with

[Typedef]
id: RO:0002436
name: molecularly_interacts_with
def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." []
is_symmetric: true
is_a: RO:0002434 ! interacts with

[Typedef]
id: RO:0002437
name: biotically_interacts_with
def: "An interaction relationship in which at least one of the partners is an organism and the other is either an organism or an abiotic entity with which the organism interacts." []
is_symmetric: true
is_a: RO:0002321 ! ecologically related to
is_a: RO:0002434 ! interacts with

[Typedef]
id: RO:0002438
name: trophically_interacts_with
def: "An interaction relationship in which the partners are related via a feeding relationship." []
is_a: RO:0002574 ! participates in a biotic-biotic interaction with

[Typedef]
id: RO:0002439
name: preys_on
def: "An interaction relationship involving a predation process, where the subject kills the target in order to eat it or to feed to siblings, offspring or group members" []
is_a: RO:0002438 ! trophically interacts with
inverse_of: RO:0002458 ! preyed upon by

[Typedef]
id: RO:0002440
name: symbiotically_interacts_with
def: "A biotic interaction in which the two organisms live together in more or less intimate association." []
is_symmetric: true
is_a: RO:0002574 ! participates in a biotic-biotic interaction with

[Typedef]
id: RO:0002441
name: commensually_interacts_with
def: "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected (GO)." []
is_a: RO:0002440 ! symbiotically interacts with

[Typedef]
id: RO:0002442
name: mutualistically_interacts_with
def: "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other (GO)." []
is_a: RO:0002440 ! symbiotically interacts with

[Typedef]
id: RO:0002443
name: interacts_with_via_parasite-host_interaction
def: "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms (GO)." []
is_a: RO:0002440 ! symbiotically interacts with

[Typedef]
id: RO:0002444
name: parasite_of
synonym: "direct parasite of" EXACT []
is_a: RO:0002443 ! interacts with via parasite-host interaction
is_a: RO:0002454 ! has host
inverse_of: RO:0002445 ! parasitized by

[Typedef]
id: RO:0002445
name: parasitized_by
synonym: "directly parasitized by" EXACT []
is_a: RO:0002443 ! interacts with via parasite-host interaction
is_a: RO:0002453 ! host of

[Typedef]
id: RO:0002446
name: participates_in_a_abiotic-biotic_interaction_with
def: "A biotic interaction relationship in which one partner is an organism and the other partner is inorganic. For example, the relationship between a sponge and the substrate to which is it anchored." []
synonym: "semibiotically interacts with" RELATED []
is_a: RO:0002437 ! biotically interacts with

[Typedef]
id: RO:0002447
name: phosphorylates
is_a: RO:0002436 ! molecularly interacts with

[Typedef]
id: RO:0002448
name: directly_regulates_activity_of
def: "The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.\n\nA and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B." []
synonym: "molecularly controls" EXACT []
is_a: RO:0002436 ! molecularly interacts with
is_a: RO:0011002 ! regulates activity of

[Typedef]
id: RO:0002449
name: directly_negatively_regulates_activity_of
def: "The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B." []
synonym: "molecularly decreases activity of" EXACT []
is_a: RO:0002448 ! directly regulates activity of

[Typedef]
id: RO:0002450
name: directly_positively_regulates_activity_of
def: "The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. \nFor example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B." []
synonym: "molecularly increases activity of" EXACT []
is_a: RO:0002448 ! directly regulates activity of

[Typedef]
id: RO:0002451
name: transmitted_by
def: "A relationship that holds between a disease and organism" []
is_a: RO:0002321 ! ecologically related to

[Typedef]
id: RO:0002452
name: has_symptom
def: "A relation that holds between a disease or an organism and a phenotype" []
is_a: RO:0002200 ! has phenotype

[Typedef]
id: RO:0002453
name: host_of
is_a: RO:0002440 ! symbiotically interacts with

[Typedef]
id: RO:0002454
name: has_host
def: "X 'has host' y if and only if: x is an organism, y is an organism, and x can live on the surface of or within the body of y" []
is_a: RO:0002440 ! symbiotically interacts with

[Typedef]
id: RO:0002455
name: pollinates
is_a: RO:0002442 ! mutualistically interacts with
inverse_of: RO:0002456 ! pollinated by

[Typedef]
id: RO:0002456
name: pollinated_by
is_a: RO:0002442 ! mutualistically interacts with

[Typedef]
id: RO:0002457
name: acquires_nutrients_from
is_a: RO:0002438 ! trophically interacts with
inverse_of: RO:0002469 ! provides nutrients for

[Typedef]
id: RO:0002458
name: preyed_upon_by
def: "inverse of preys on" []
is_a: RO:0002438 ! trophically interacts with

[Typedef]
id: RO:0002459
name: is_vector_for
is_a: RO:0002574 ! participates in a biotic-biotic interaction with
inverse_of: RO:0002460 ! has vector

[Typedef]
id: RO:0002460
name: has_vector
is_a: RO:0002574 ! participates in a biotic-biotic interaction with

[Typedef]
id: RO:0002461
name: partner_in
is_a: RO:0000056 ! participates in

[Typedef]
id: RO:0002462
name: subject_participant_in
is_a: RO:0002461 ! partner in

[Typedef]
id: RO:0002463
name: target_participant_in
is_a: RO:0002461 ! partner in

[Typedef]
id: RO:0002464
name: helper_property_(not_for_use_in_curation)

[Typedef]
id: RO:0002465
name: is_symbiosis
is_a: RO:0002563 ! interaction relation helper property

[Typedef]
id: RO:0002466
name: is_commensalism
is_a: RO:0002465 ! is symbiosis

[Typedef]
id: RO:0002467
name: is_mutualism
is_a: RO:0002465 ! is symbiosis

[Typedef]
id: RO:0002468
name: is_parasitism
is_a: RO:0002465 ! is symbiosis

[Typedef]
id: RO:0002469
name: provides_nutrients_for
is_a: RO:0002438 ! trophically interacts with

[Typedef]
id: RO:0002470
name: eats
is_a: RO:0002438 ! trophically interacts with

[Typedef]
id: RO:0002471
name: is_eaten_by
is_a: RO:0002438 ! trophically interacts with

[Typedef]
id: RO:0002472
name: is_evidence_for
def: "A relationship between a piece of evidence a and some entity b, where b is  an information content entity, material entity or process, and \nthe a supports either the existence of b, or the truth value of b." []
is_a: RO:0002616 ! related via evidence or inference to
inverse_of: RO:0002558 ! has evidence

[Typedef]
id: RO:0002473
name: composed_primarily_of
def: "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." []
is_a: BFO:0000051 ! has part

[Typedef]
id: RO:0002476
name: child_nucleus_of
def: "c is a child nucleus of d if and only if c and d are both nuclei and parts of cells c' and d', where c' is derived from d' by mitosis and the genetic material in c is a copy of the generic material in d" []
is_a: RO:0002258 ! developmentally preceded by

[Typedef]
id: RO:0002477
name: child_nucleus_of_in_hermaphrodite
def: "A child nucleus relationship in which the cells are part of a hermaphroditic organism" []
is_a: RO:0002476 ! child nucleus of

[Typedef]
id: RO:0002478
name: child_nucleus_of_in_male
def: "A child nucleus relationship in which the cells are part of a male organism" []
is_a: RO:0002476 ! child nucleus of

[Typedef]
id: RO:0002479
name: has_part_that_occurs_in
def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." []
holds_over_chain: BFO:0000051 BFO:0000066 {RO:0002581="true"}

[Typedef]
id: RO:0002480
name: ubiquitinates
def: "An interaction relation between x and y in which x catalyzes a reaction in which one or more ubiquitin groups are added to y" []
is_a: RO:0002436 ! molecularly interacts with

[Typedef]
id: RO:0002481
name: is_kinase_activity
is_a: RO:0002564 ! molecular interaction relation helper property

[Typedef]
id: RO:0002482
name: is_ubiquitination
is_a: RO:0002564 ! molecular interaction relation helper property

[Typedef]
id: RO:0002485
name: receives_input_from
is_a: RO:0002170 ! connected to
inverse_of: RO:0002486 ! sends output to

[Typedef]
id: RO:0002486
name: sends_output_to
is_a: RO:0002170 ! connected to

[Typedef]
id: RO:0002487
name: relation_between_physical_entity_and_a_process_or_stage

[Typedef]
id: RO:0002488
name: existence_starts_during
def: "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." []
holds_over_chain: RO:0002583 BFO:0000050
is_a: RO:0002490 ! existence overlaps
is_a: RO:0002496 ! existence starts during or after
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002489
name: existence_starts_with
def: "x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y)." []
is_a: RO:0002488 ! existence starts during

[Typedef]
id: RO:0002490
name: existence_overlaps
def: "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" []
is_a: RO:0002487 ! relation between physical entity and a process or stage

[Typedef]
id: RO:0002491
name: existence_starts_and_ends_during
def: "x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)" []
synonym: "exists during" EXACT []
is_a: RO:0002488 ! existence starts during
is_a: RO:0002492 ! existence ends during

[Typedef]
id: RO:0002492
name: existence_ends_during
def: "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." []
holds_over_chain: RO:0002593 BFO:0000050
is_a: RO:0002490 ! existence overlaps
is_a: RO:0002497 ! existence ends during or before
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0002493
name: existence_ends_with
def: "x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y)." []
is_a: RO:0002492 ! existence ends during

[Typedef]
id: RO:0002494
name: transformation_of
def: "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" []
is_transitive: true
is_a: RO:0002202 ! develops from

[Typedef]
id: RO:0002495
name: immediate_transformation_of
def: "x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t" []
is_a: RO:0002207 ! directly develops from
is_a: RO:0002494 ! transformation of

[Typedef]
id: RO:0002496
name: existence_starts_during_or_after
def: "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." []
holds_over_chain: BFO:0000050 RO:0002496
holds_over_chain: RO:0002258 RO:0002496
is_a: RO:0002487 ! relation between physical entity and a process or stage
transitive_over: BFO:0000050 ! part of
transitive_over: BFO:0000062 ! preceded by
transitive_over: RO:0002082 ! simultaneous with

[Typedef]
id: RO:0002497
name: existence_ends_during_or_before
def: "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." []
holds_over_chain: BFO:0000050 RO:0002497
holds_over_chain: RO:0002286 RO:0002497
is_a: RO:0002487 ! relation between physical entity and a process or stage
transitive_over: BFO:0000050 ! part of
transitive_over: BFO:0000063 ! precedes
transitive_over: RO:0002082 ! simultaneous with

[Typedef]
id: RO:0002500
name: causal_agent_in_process
def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" []
is_a: RO:0002595 ! causal relation between material entity and a process
inverse_of: RO:0002608 ! process has causal agent

[Typedef]
id: RO:0002501
name: causal_relation_between_processes
def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q." []
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002502
name: depends_on

[Typedef]
id: RO:0002503
name: towards
def: "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" []
is_a: RO:0002502 ! depends on

[Typedef]
id: RO:0002505
name: has_intermediate
def: "p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c" []
is_a: RO:0000057 ! has participant

[Typedef]
id: RO:0002506
name: causal_relation_between_entities
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002507
name: determined_by
def: "s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s." []
is_a: BFO:0000050 ! part of
is_a: RO:0002509 ! determined by part of
is_a: RO:0002559 ! causally influenced by
inverse_of: RO:0002508 ! determines

[Typedef]
id: RO:0002508
name: determines
def: "inverse of determined by" []
is_a: RO:0002566 ! causally influences

[Typedef]
id: RO:0002509
name: determined_by_part_of
def: "s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w." []
holds_over_chain: RO:0002507 BFO:0000050 {RO:0002582="true"}
is_a: RO:0002131 ! overlaps
is_a: RO:0002506 ! causal relation between entities

[Typedef]
id: RO:0002510
name: transcribed_from
def: "x is transcribed from y if and only if x is synthesized from template y" []
is_a: RO:0002330 ! genomically related to
inverse_of: RO:0002511 ! transcribed to

[Typedef]
id: RO:0002511
name: transcribed_to
def: "inverse of transcribed from" []
is_a: RO:0002330 ! genomically related to

[Typedef]
id: RO:0002512
name: ribosomal_translation_of
def: "x is the ribosomal translation of y if and only if a ribosome reads x through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces y" []
is_a: RO:0002330 ! genomically related to
inverse_of: RO:0002513 ! ribosomally translates to

[Typedef]
id: RO:0002513
name: ribosomally_translates_to
def: "inverse of ribosomal translation of" []
is_a: RO:0002330 ! genomically related to

[Typedef]
id: RO:0002514
name: sequentially_related_to
def: "A relation that holds between two entities that have the property of being sequences or having sequences. " []

[Typedef]
id: RO:0002515
name: sequentially_adjacent_to
def: "x is sequentially adjacent to y iff x and y do not overlap and if there are no base units intervening between x and y" []
is_a: RO:0002527 ! does not overlap sequence of

[Typedef]
id: RO:0002516
name: has_start_sequence
def: "x has start sequence y if the start of x is identical to the start of y, and x has y as a subsequence" []
is_transitive: true
is_a: RO:0002524 ! has subsequence
inverse_of: RO:0002517 ! is start sequence of

[Typedef]
id: RO:0002517
name: is_start_sequence_of
def: "inverse of has start sequence" []
is_transitive: true
is_a: RO:0002525 ! is subsequence of

[Typedef]
id: RO:0002518
name: has_end_sequence
def: "x has end sequence y if the end of x is identical to the end of y, and x has y as a subsequence" []
is_transitive: true
is_a: RO:0002524 ! has subsequence
inverse_of: RO:0002519 ! is end sequence of

[Typedef]
id: RO:0002519
name: is_end_sequence_of
def: "inverse of has end sequence" []
is_transitive: true
is_a: RO:0002525 ! is subsequence of

[Typedef]
id: RO:0002520
name: is_consecutive_sequence_of
def: "x is a consecutive sequence of y iff x has subsequence y, and all the parts of x are made of zero or more repetitions of y or sequences as the same type as y." []
is_a: RO:0002524 ! has subsequence

[Typedef]
id: RO:0002521
name: is_sequentially_aligned_with
def: "x is sequentially aligned with if a significant portion bases of x and y correspond in terms of their base type and their relative ordering" []
is_symmetric: true
is_a: RO:0002514 ! sequentially related to

[Typedef]
id: RO:0002522
name: bounds_sequence_of
def: "x bounds the sequence of y iff the upstream-most part of x is upstream of or coincident with the upstream-most part of y, and the downstream-most part of x is downstream of or coincident with the downstream-most part of y" []
is_transitive: true
is_a: RO:0002514 ! sequentially related to
inverse_of: RO:0002523 ! is bound by sequence of

[Typedef]
id: RO:0002523
name: is_bound_by_sequence_of
def: "inverse of bounds sequence of" []
is_transitive: true
is_a: RO:0002514 ! sequentially related to

[Typedef]
id: RO:0002524
name: has_subsequence
def: "x has subsequence y iff all of the sequence parts of y are sequence parts of x" []
is_transitive: true
is_a: BFO:0000051 ! has part
is_a: RO:0002522 ! bounds sequence of
is_a: RO:0002526 ! overlaps sequence of
inverse_of: RO:0002525 ! is subsequence of

[Typedef]
id: RO:0002525
name: is_subsequence_of
def: "inverse of has subsequence" []
is_transitive: true
is_a: BFO:0000050 ! part of
is_a: RO:0002523 ! is bound by sequence of
is_a: RO:0002526 ! overlaps sequence of

[Typedef]
id: RO:0002526
name: overlaps_sequence_of
def: "x overlaps the sequence of y if and only if x has a subsequence z and z is a subsequence of y." []
holds_over_chain: RO:0002524 RO:0002525
is_symmetric: true
is_a: RO:0002131 ! overlaps
is_a: RO:0002514 ! sequentially related to

[Typedef]
id: RO:0002527
name: does_not_overlap_sequence_of
def: "x does not overlap the sequence of y if and only if there is no z such that x has a subsequence z and z is a subsequence of y." []
is_symmetric: true
is_a: RO:0002514 ! sequentially related to

[Typedef]
id: RO:0002528
name: is_upstream_of_sequence_of
def: "inverse of downstream of sequence of" []
is_transitive: true
is_a: RO:0002527 ! does not overlap sequence of

[Typedef]
id: RO:0002529
name: is_downstream_of_sequence_of
def: "x is downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, or (2) x and y are sequence units, and x is either immediately downstream of y, or transitively downstream of y." []
is_transitive: true
is_a: RO:0002527 ! does not overlap sequence of
inverse_of: RO:0002529 ! is downstream of sequence of

[Typedef]
id: RO:0002530
name: is_immediately_downstream_of_sequence_of
def: "x is immediately downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, and x is sequentially adjacent to y, or (2) x and y are sequence units, in which case the immediately downstream relation is primitive and defined by context: for DNA bases, y would be adjacent and 5' to y" []
is_a: RO:0002515 ! sequentially adjacent to
is_a: RO:0002529 ! is downstream of sequence of

[Typedef]
id: RO:0002531
name: is_immediately_upstream_of_sequence_of
def: "inverse of immediately downstream of" []
is_a: RO:0002515 ! sequentially adjacent to
is_a: RO:0002528 ! is upstream of sequence of

[Typedef]
id: RO:0002551
name: has_skeleton
def: "A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision." []
is_a: BFO:0000051 ! has part
inverse_of: RO:0002576 ! skeleton of
is_asymmetric: true

[Typedef]
id: RO:0002552
name: results_in_ending_of
def: "p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded." []
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002553
name: hyperparasite_of
def: "x is a hyperparasite of y iff x is a parasite of a parasite of the target organism y" []
synonym: "epiparasite of" RELATED []
synonym: "hyperparasitoid of" NARROW []
holds_over_chain: RO:0002444 RO:0002444
is_a: RO:0002454 ! has host
inverse_of: RO:0002554 ! hyperparasitized by

[Typedef]
id: RO:0002554
name: hyperparasitized_by
def: "inverse of hyperparasite of" []
synonym: "has epiparasite" RELATED []
synonym: "has hyperparasite" RELATED []
synonym: "hyperparasitoidized by" RELATED []
holds_over_chain: RO:0002445 RO:0002445
is_a: RO:0002453 ! host of

[Typedef]
id: RO:0002555
name: allelopath_of
is_a: RO:0002574 ! participates in a biotic-biotic interaction with

[Typedef]
id: RO:0002556
name: pathogen_of
is_a: RO:0002454 ! has host
inverse_of: RO:0002557 ! has pathogen

[Typedef]
id: RO:0002557
name: has_pathogen
is_a: RO:0002453 ! host of

[Typedef]
id: RO:0002558
name: has_evidence
def: "inverse of is evidence for" []
is_a: RO:0002616 ! related via evidence or inference to

[Typedef]
id: RO:0002559
name: causally_influenced_by
is_a: RO:0002506 ! causal relation between entities
inverse_of: RO:0002566 ! causally influences

[Typedef]
id: RO:0002563
name: interaction_relation_helper_property
is_a: RO:0002464 ! helper property (not for use in curation)

[Typedef]
id: RO:0002564
name: molecular_interaction_relation_helper_property
is_a: RO:0002563 ! interaction relation helper property

[Typedef]
id: RO:0002565
name: results_in_movement_of
def: "Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c" []
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002566
name: causally_influences
def: "The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size)." []
is_a: RO:0002506 ! causal relation between entities

[Typedef]
id: RO:0002567
name: biomechanically_related_to
def: "A relation that holds between elements of a musculoskeletal system or its analogs." []
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0002568
name: has_muscle_antagonist
def: "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." []
is_a: RO:0002567 ! biomechanically related to

[Typedef]
id: RO:0002569
name: has_branching_part
def: "inverse of branching part of" []
is_transitive: true
is_a: BFO:0000051 ! has part
is_a: RO:0002375 ! in branching relationship with

[Typedef]
id: RO:0002570
name: conduit_for
def: "x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x." []
is_a: RO:0002131 ! overlaps

[Typedef]
id: RO:0002571
name: lumen_of
def: "x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull." []
is_a: BFO:0000050 ! part of

[Typedef]
id: RO:0002572
name: luminal_space_of
def: "s is luminal space of x iff s is lumen_of x and s is an immaterial entity" []
is_a: RO:0002571 ! lumen of

[Typedef]
id: RO:0002573
name: has_modifier
def: "A relation that holds between an attribute or a qualifier and another attribute." []

[Typedef]
id: RO:0002574
name: participates_in_a_biotic-biotic_interaction_with
is_a: RO:0002437 ! biotically interacts with

[Typedef]
id: RO:0002576
name: skeleton_of
def: "inverse of has skeleton" []
is_a: BFO:0000050 ! part of

[Typedef]
id: RO:0002578
name: directly_regulates
def: "p directly regulates q iff p is immediately causally upstream of q and p regulates q." []
is_a: RO:0002211 ! regulates
is_a: RO:0002412 ! immediately causally upstream of

[Typedef]
id: RO:0002583
name: existence_starts_at_end_of
def: "holds between x and y if and only if the time point at which x starts is equivalent to the time point at which y ends. Formally: iff α(x) = ω(y)." []
is_a: RO:0002496 ! existence starts during or after

[Typedef]
id: RO:0002584
name: has_part_structure_that_is_capable_of
def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" []
holds_over_chain: BFO:0000051 RO:0002215
is_a: RO:0002328 ! functionally related to
is_a: RO:0002595 ! causal relation between material entity and a process

[Typedef]
id: RO:0002585
name: results_in_closure_of
is_a: RO:0002295 ! results in developmental progression of
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002586
name: results_in_breakdown_of
def: "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" []
is_a: RO:0002233 ! has input

[Typedef]
id: RO:0002587
name: results_in_synthesis_of
is_a: RO:0002297 ! results in formation of anatomical entity

[Typedef]
id: RO:0002588
name: results_in_assembly_of
is_a: RO:0002297 ! results in formation of anatomical entity
is_a: RO:0002592 ! results in organization of

[Typedef]
id: RO:0002589
name: results_in_catabolism_of
def: "p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released." []
is_a: RO:0002586 ! results in breakdown of

[Typedef]
id: RO:0002590
name: results_in_disassembly_of
is_a: RO:0002586 ! results in breakdown of
is_a: RO:0002592 ! results in organization of

[Typedef]
id: RO:0002591
name: results_in_remodeling_of
is_a: RO:0002233 ! has input
is_a: RO:0002592 ! results in organization of

[Typedef]
id: RO:0002592
name: results_in_organization_of
def: "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" []
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0002593
name: existence_ends_at_start_of
def: "holds between x and y if and only if the time point at which x ends is equivalent to the time point at which y starts. Formally: iff ω(x) = α(y)." []
is_a: RO:0002497 ! existence ends during or before

[Typedef]
id: RO:0002595
name: causal_relation_between_material_entity_and_a_process
def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." []
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002596
name: capable_of_regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." []
holds_over_chain: RO:0002215 RO:0002211
is_a: RO:0002500 ! causal agent in process

[Typedef]
id: RO:0002597
name: capable_of_negatively_regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." []
holds_over_chain: RO:0002215 RO:0002212
is_a: RO:0002596 ! capable of regulating

[Typedef]
id: RO:0002598
name: capable_of_positively_regulating
def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." []
holds_over_chain: RO:0002215 RO:0002213
is_a: RO:0002596 ! capable of regulating

[Typedef]
id: RO:0002599
name: capable_of_inhibiting_or_preventing_pathological_process
def: "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p." []
is_a: RO:0002597 ! capable of negatively regulating

[Typedef]
id: RO:0002600
name: capable_of_upregulating_or_causing_pathological_process
def: "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p." []
is_a: RO:0002598 ! capable of positively regulating

[Typedef]
id: RO:0002606
name: is_substance_that_treats
def: "c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d." []
is_a: RO:0002599 ! capable of inhibiting or preventing pathological process

[Typedef]
id: RO:0002607
name: is_marker_for
def: "c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d." []
is_a: RO:0002610 ! correlated with

[Typedef]
id: RO:0002608
name: process_has_causal_agent
def: "Inverse of 'causal agent in process'" []
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0002609
name: obsolete_related_via_dependence_to
def: "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." []
is_obsolete: true

[Typedef]
id: RO:0002610
name: correlated_with
def: "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." []

[Typedef]
id: RO:0002614
name: is_evidence_with_support_from
def: "A relationship between a piece of evidence and an entity that plays a role in supporting that evidence." []
is_a: RO:0002616 ! related via evidence or inference to

[Typedef]
id: RO:0002615
name: has_model
def: "Inverse of is-model-of" []
inverse_of: RO:0003301 ! has role in modeling

[Typedef]
id: RO:0002616
name: related_via_evidence_or_inference_to

[Typedef]
id: RO:0002618
name: visits
is_a: RO:0002574 ! participates in a biotic-biotic interaction with
inverse_of: RO:0002619 ! visited by

[Typedef]
id: RO:0002619
name: visited_by
is_a: RO:0002574 ! participates in a biotic-biotic interaction with

[Typedef]
id: RO:0002622
name: visits_flowers_of
is_a: RO:0002618 ! visits
inverse_of: RO:0002623 ! has flowers visited by

[Typedef]
id: RO:0002623
name: has_flowers_visited_by
is_a: RO:0002619 ! visited by

[Typedef]
id: RO:0002624
name: lays_eggs_in
is_a: RO:0002444 ! parasite of
is_a: RO:0002618 ! visits
inverse_of: RO:0002625 ! has eggs laid in by

[Typedef]
id: RO:0002625
name: has_eggs_laid_in_by
is_a: RO:0002445 ! parasitized by
is_a: RO:0002619 ! visited by

[Typedef]
id: RO:0002626
name: kills
is_a: RO:0002574 ! participates in a biotic-biotic interaction with
inverse_of: RO:0002627 ! is killed by

[Typedef]
id: RO:0002627
name: is_killed_by
is_a: RO:0002574 ! participates in a biotic-biotic interaction with

[Typedef]
id: RO:0002629
name: directly_positively_regulates
def: "p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q." []
is_a: RO:0002213 ! positively regulates
is_a: RO:0002578 ! directly regulates

[Typedef]
id: RO:0002630
name: directly_negatively_regulates
def: "p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q." []
is_a: RO:0002212 ! negatively regulates
is_a: RO:0002578 ! directly regulates

[Typedef]
id: RO:0002632
name: ectoparasite_of
def: "A sub-relation of parasite-of in which the parasite lives on or in the integumental system of the host" []
is_a: RO:0002444 ! parasite of
inverse_of: RO:0002633 ! has ectoparasite

[Typedef]
id: RO:0002633
name: has_ectoparasite
def: "inverse of ectoparasite of" []
is_a: RO:0002445 ! parasitized by

[Typedef]
id: RO:0002634
name: endoparasite_of
synonym: "lives inside of" RELATED []
is_a: RO:0002444 ! parasite of
inverse_of: RO:0002635 ! has endoparasite

[Typedef]
id: RO:0002635
name: has_endoparasite
is_a: RO:0002445 ! parasitized by

[Typedef]
id: RO:0002636
name: mesoparasite_of
def: "A sub-relation of parasite-of in which the parasite is partially an endoparasite and partially an ectoparasite" []
is_a: RO:0002444 ! parasite of
inverse_of: RO:0002637 ! has mesoparasite

[Typedef]
id: RO:0002637
name: has_mesoparasite
def: "inverse of mesoparasite of" []
is_a: RO:0002445 ! parasitized by

[Typedef]
id: RO:0002638
name: intercellular_endoparasite_of
def: "A sub-relation of endoparasite-of in which the parasite inhabits the spaces between host cells." []
is_a: RO:0002634 ! endoparasite of
inverse_of: RO:0002639 ! has intercellular endoparasite

[Typedef]
id: RO:0002639
name: has_intercellular_endoparasite
def: "inverse of intercellular endoparasite of" []
is_a: RO:0002635 ! has endoparasite

[Typedef]
id: RO:0002640
name: intracellular_endoparasite_of
def: "A sub-relation of endoparasite-of in which the parasite inhabits host cells." []
is_a: RO:0002634 ! endoparasite of
inverse_of: RO:0002641 ! has intracellular endoparasite

[Typedef]
id: RO:0002641
name: has_intracellular_endoparasite
def: "inverse of intracellular endoparasite of" []
is_a: RO:0002635 ! has endoparasite

[Typedef]
id: RO:0002801
name: co-roosts_with
def: "Two or more individuals sharing the same roost site (cave, mine, tree or tree hollow, animal burrow, leaf tent, rock crack, space in man-made structure, etc.). Individuals that are sharing a communal roost may be said to be co-roosting. The roost may be either a day roost where the individuals rest during daytime hours, or a night roost where individuals roost to feed, groom, or rest in between flights and/or foraging bouts.  Communal roosting as thus defined is an umbrella term within which different specialized types -- which are not mutually exclusive -- may be recognized based on taxonomy and the temporal and spatial relationships of the individuals that are co-roosting." []
is_symmetric: true
is_a: RO:0008506 ! ecologically co-occurs with

[Typedef]
id: RO:0002802
name: reservoir_host_of
def: "A relation between a host organism and a hosted organism in which the hosted organism naturally occurs in an indefinitely maintained reservoir provided by the host." []
is_a: RO:0002453 ! host of
inverse_of: RO:0002803 ! has reservoir host

[Typedef]
id: RO:0002803
name: has_reservoir_host
def: "inverse of reservoir host of" []
is_a: RO:0002454 ! has host

[Typedef]
id: RO:0003000
name: produces
def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." []
inverse_of: RO:0003001 ! produced by

[Typedef]
id: RO:0003001
name: produced_by
def: "a produced_by b iff some process that occurs_in b has_output a." []

[Typedef]
id: RO:0003002
name: represses_expression_of
def: "Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA." []
is_a: RO:0002449 ! directly negatively regulates activity of

[Typedef]
id: RO:0003003
name: increases_expression_of
def: "Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA." []
is_a: RO:0002450 ! directly positively regulates activity of

[Typedef]
id: RO:0003301
name: has_role_in_modeling
def: "A relation between a biological, experimental, or computational artifact and an entity it is used to study, in virtue of its replicating or approximating features of the studied entity." []
is_asymmetric: true

[Typedef]
id: RO:0003302
name: causes_or_contributes_to_condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." []
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0003303
name: causes_condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." []
is_a: RO:0003302 ! causes or contributes to condition

[Typedef]
id: RO:0003304
name: contributes_to_condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition." []
is_a: RO:0003302 ! causes or contributes to condition

[Typedef]
id: RO:0003305
name: contributes_to_severity_of_condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual." []
is_a: RO:0003304 ! contributes to condition

[Typedef]
id: RO:0003306
name: contributes_to_frequency_of_condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." []
is_a: RO:0003304 ! contributes to condition

[Typedef]
id: RO:0003307
name: ameliorates_condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." []
is_a: RO:0003305 ! contributes to severity of condition

[Typedef]
id: RO:0003308
name: correlated_with_condition
def: "A relationship between an entity and a condition (phenotype or disease) with which it exhibits a statistical dependence relationship." []
is_a: RO:0002610 ! correlated with

[Typedef]
id: RO:0003309
name: exacerbates_condition
def: "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." []
is_a: RO:0003305 ! contributes to severity of condition

[Typedef]
id: RO:0003310
name: condition_ameliorated_by
def: "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." []
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0003311
name: condition_exacerbated_by
def: "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." []
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0004000
name: condition_has_genetic_basis_in
is_a: RO:0002410 ! causally related to
inverse_of: RO:0004010 ! is genetic basis for condition

[Typedef]
id: RO:0004001
name: has_material_basis_in_gain_of_function_germline_mutation_in
is_a: RO:0004000 ! condition has genetic basis in
inverse_of: RO:0004011 ! is causal gain of function germline mutation of in

[Typedef]
id: RO:0004002
name: has_material_basis_in_loss_of_function_germline_mutation_in
is_a: RO:0004000 ! condition has genetic basis in
inverse_of: RO:0004012 ! is causal loss of function germline mutation of in

[Typedef]
id: RO:0004003
name: has_material_basis_in_germline_mutation_in
is_a: RO:0004000 ! condition has genetic basis in
inverse_of: RO:0004013 ! is causal germline mutation in

[Typedef]
id: RO:0004004
name: has_material_basis_in_somatic_mutation_in
is_a: RO:0004000 ! condition has genetic basis in
inverse_of: RO:0004014 ! is causal somatic mutation in

[Typedef]
id: RO:0004005
name: has_major_susceptibility_factor
is_a: RO:0004000 ! condition has genetic basis in
inverse_of: RO:0004015 ! is causal susceptibility factor for

[Typedef]
id: RO:0004006
name: has_partial_material_basis_in_germline_mutation_in
is_a: RO:0004000 ! condition has genetic basis in
inverse_of: RO:0004016 ! is causal germline mutation partially giving rise to

[Typedef]
id: RO:0004007
name: has_primary_input_or_output
def: "p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c." []
is_a: RO:0000057 ! has participant

[Typedef]
id: RO:0004008
name: has_primary_output
def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"}
is_a: RO:0002234 ! has output
is_a: RO:0004007 ! has primary input or output

[Typedef]
id: RO:0004009
name: has_primary_input
def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"}
is_a: RO:0002233 ! has input
is_a: RO:0004007 ! has primary input or output

[Typedef]
id: RO:0004010
name: is_genetic_basis_for_condition
is_a: RO:0004018 ! is basis for realizable

[Typedef]
id: RO:0004011
name: is_causal_gain_of_function_germline_mutation_of_in
def: "Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." []
is_a: RO:0004010 ! is genetic basis for condition

[Typedef]
id: RO:0004012
name: is_causal_loss_of_function_germline_mutation_of_in
def: "Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." []
is_a: RO:0004010 ! is genetic basis for condition

[Typedef]
id: RO:0004013
name: is_causal_germline_mutation_in
def: "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." []
is_a: RO:0003303 ! causes condition
is_a: RO:0004010 ! is genetic basis for condition

[Typedef]
id: RO:0004014
name: is_causal_somatic_mutation_in
def: "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]." []
is_a: RO:0003303 ! causes condition
is_a: RO:0004010 ! is genetic basis for condition

[Typedef]
id: RO:0004015
name: is_causal_susceptibility_factor_for
def: "Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition  and that is necessary but not sufficient to develop the condition[modified from orphanet]." []
is_a: RO:0004010 ! is genetic basis for condition

[Typedef]
id: RO:0004016
name: is_causal_germline_mutation_partially_giving_rise_to
def: "Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]." []
is_a: RO:0003304 ! contributes to condition
is_a: RO:0004010 ! is genetic basis for condition

[Typedef]
id: RO:0004017
name: realizable_has_basis_in
is_a: RO:0002410 ! causally related to
inverse_of: RO:0004018 ! is basis for realizable

[Typedef]
id: RO:0004018
name: is_basis_for_realizable
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0004019
name: disease_has_basis_in
is_a: RO:0004017 ! realizable has basis in
is_a: RO:0004023 ! causal relationship with disease as subject

[Typedef]
id: RO:0004020
name: disease_has_basis_in_dysfunction_of
def: "A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function." []
is_a: RO:0004019 ! disease has basis in

[Typedef]
id: RO:0004021
name: disease_has_basis_in_disruption_of
def: "A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process." []
is_a: RO:0004019 ! disease has basis in

[Typedef]
id: RO:0004022
name: disease_has_basis_in_feature
def: "A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature." []
is_a: RO:0002200 ! has phenotype
is_a: RO:0004019 ! disease has basis in

[Typedef]
id: RO:0004023
name: causal_relationship_with_disease_as_subject
is_a: RO:0002410 ! causally related to
is_a: RO:0040035 ! disease relationship

[Typedef]
id: RO:0004024
name: disease_causes_disruption_of
def: "A relationship between a disease and a process where the disease process disrupts the execution of the process." []
holds_over_chain: RO:0004025 RO:0002215
is_a: RO:0004023 ! causal relationship with disease as subject
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0004025
name: disease_causes_dysfunction_of
is_a: RO:0004023 ! causal relationship with disease as subject
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0004026
name: disease_has_location
def: "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." []
is_a: RO:0040035 ! disease relationship

[Typedef]
id: RO:0004027
name: disease_has_inflammation_site
def: "A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity" []
is_a: RO:0004026 ! disease has location

[Typedef]
id: RO:0004028
name: realized_in_response_to_stimulus
def: "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." []
holds_over_chain: RO:0009501 RO:0002233
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0004029
name: disease_has_feature
def: "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." []
is_a: RO:0040035 ! disease relationship

[Typedef]
id: RO:0004030
name: disease_arises_from_alteration_in_structure
def: "A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. Anatomical structure includes cellular and sub-cellular entities, such as chromosome and organelles." []
is_a: RO:0004019 ! disease has basis in

[Typedef]
id: RO:0004031
name: enables_subfunction
def: "Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P." []
holds_over_chain: RO:0002327 BFO:0000051
is_a: RO:0002328 ! functionally related to

[Typedef]
id: RO:0004032
name: acts_upstream_of_or_within,_positive_effect
holds_over_chain: RO:0002327 RO:0004047
is_a: RO:0002264 ! acts upstream of or within

[Typedef]
id: RO:0004033
name: acts_upstream_of_or_within,_negative_effect
holds_over_chain: RO:0002327 RO:0004046
is_a: RO:0002264 ! acts upstream of or within

[Typedef]
id: RO:0004034
name: acts_upstream_of,_positive_effect
def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" []
holds_over_chain: RO:0002327 RO:0002304
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004032 ! acts upstream of or within, positive effect

[Typedef]
id: RO:0004035
name: acts_upstream_of,_negative_effect
def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" []
holds_over_chain: RO:0002327 RO:0002305
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004033 ! acts upstream of or within, negative effect

[Typedef]
id: RO:0004046
name: causally_upstream_of_or_within,_negative_effect
is_a: RO:0002418 ! causally upstream of or within

[Typedef]
id: RO:0004047
name: causally_upstream_of_or_within,_positive_effect
is_a: RO:0002418 ! causally upstream of or within

[Typedef]
id: RO:0004096
name: DEPRECATED_inheres_in
is_obsolete: true

[Typedef]
id: RO:0004097
name: DEPRECATED_bearer_of
is_obsolete: true

[Typedef]
id: RO:0007000
name: has_driver
def: "A relation between two entities, in which one of the entities is any natural or human-influenced factor that directly or indirectly causes a change in the other entity." []

[Typedef]
id: RO:0007001
name: has_disease_driver
def: "A relation between an entity and a disease of a host, in which the entity is not part of the host itself, and the condition results in pathological processes." []
is_a: RO:0007000 ! has driver

[Typedef]
id: RO:0008501
name: epiphyte_of
def: "An interaction relationship wherein a plant or algae is living on the outside surface of another plant." []
is_a: RO:0002440 ! symbiotically interacts with
inverse_of: RO:0008502 ! has epiphyte

[Typedef]
id: RO:0008502
name: has_epiphyte
def: "inverse of epiphyte of" []
is_a: RO:0002440 ! symbiotically interacts with

[Typedef]
id: RO:0008503
name: kleptoparasite_of
def: "A sub-relation of parasite of in which a parasite steals resources from another organism, usually food or nest material" []
is_a: RO:0002444 ! parasite of
inverse_of: RO:0008504 ! kleptoparasitized by

[Typedef]
id: RO:0008504
name: kleptoparasitized_by
def: "inverse of kleptoparasite of" []
is_a: RO:0002445 ! parasitized by

[Typedef]
id: RO:0008505
name: creates_habitat_for
def: "An interaction relationship wherein one organism creates a structure or environment that is lived in by another organism." []
is_a: RO:0002321 ! ecologically related to

[Typedef]
id: RO:0008506
name: ecologically_co-occurs_with
def: "An interaction relationship describing organisms that often occur together at the same time and space or in the same environment." []
is_symmetric: true
is_a: RO:0002321 ! ecologically related to

[Typedef]
id: RO:0008507
name: lays_eggs_on
def: "An interaction relationship in which organism a lays eggs on the outside surface of organism b. Organism b is neither helped nor harmed in the process of egg laying or incubation." []
is_a: RO:0002618 ! visits
inverse_of: RO:0008508 ! has eggs laid on by

[Typedef]
id: RO:0008508
name: has_eggs_laid_on_by
def: "inverse of lays eggs on" []
is_a: RO:0002619 ! visited by

[Typedef]
id: RO:0008509
name: has_roost
def: "x 'has roost' y if and only if: x is an organism, y is a habitat, and y can support rest behaviors x." []
is_a: RO:0002303 ! has habitat

[Typedef]
id: RO:0009001
name: has_substance_added
def: "\"has substance added\" is a relation existing between a (physical) entity and a substance in which the entity has had the substance added to it at some point in time." []

[Typedef]
id: RO:0009002
name: has_substance_removed
def: "\"has substance removed\" is a relation existing between two physical entities in which the first entity has had the second entity (a substance) removed from it at some point in time." []

[Typedef]
id: RO:0009003
name: immersed_in
def: "\"immersed in\" is a relation between a (physical) entity and a fluid substance in which the entity is wholely or substantially surrounded by the substance." []

[Typedef]
id: RO:0009004
name: has_consumer
def: "'has consumer' is a relation between a material entity and an organism in which the former can normally be digested or otherwise absorbed by the latter without immediate or persistent ill effect." []

[Typedef]
id: RO:0009005
name: has_primary_substance_added
def: "'has primary substance added' indicates that an entity has had the given substance added to it in a proportion greater than any other added substance." []
is_a: RO:0009001 ! has substance added

[Typedef]
id: RO:0009501
name: realized_in_response_to
def: "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." []
synonym: "triggered by process" EXACT [https://orcid.org/0000-0002-6601-2165]
holds_over_chain: BFO:0000054 RO:0002404
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0010001
name: generically_depends_on
def: "A generically dependent continuant *b* generically depends on an independent continuant *c* at time *t* means: there inheres in *c* a specifically deendent continuant which concretizes *b* at *t*." []
synonym: "g-depends on" EXACT []
holds_over_chain: RO:0000052 RO:0000058
inverse_of: RO:0010002 ! is carrier of

[Typedef]
id: RO:0010002
name: is_carrier_of
def: "*b* is carrier of *c* at time *t* if and only if *c* *g-depends on* *b* at *t*" []
holds_over_chain: RO:0000059 RO:0000053

[Typedef]
id: RO:0011002
name: regulates_activity_of
def: "The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B." []
is_a: RO:0002566 ! causally influences

[Typedef]
id: RO:0011003
name: regulates_quantity_of
def: "The entity A has an activity that regulates the quantity or abundance or concentration of the entity B." []
is_a: RO:0002566 ! causally influences

[Typedef]
id: RO:0011004
name: indirectly_regulates_activity_of
def: "The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B." []
is_a: RO:0011002 ! regulates activity of

[Typedef]
id: RO:0011007
name: decreases_by_repression_quantity_of
def: "The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B.\n\nFor example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B." []
is_a: RO:0011023 ! indirectly negatively regulates quantity of

[Typedef]
id: RO:0011008
name: increases_by_expression_quantity_of
def: "The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B.\n\nFor example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B." []
is_a: RO:0011024 ! indirectly positively regulates quantity of

[Typedef]
id: RO:0011009
name: directly_positively_regulates_quantity_of
def: "The entity A has an activity that directly positively regulates the quantity of B." []
is_a: RO:0011021 ! directly regulates quantity of

[Typedef]
id: RO:0011010
name: directly_negatively_regulates_quantity_of
def: "The entity A has an activity that directly negatively regulates the quantity of B." []
is_a: RO:0011021 ! directly regulates quantity of

[Typedef]
id: RO:0011013
name: indirectly_positively_regulates_activity_of
def: "The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B." []
is_a: RO:0011004 ! indirectly regulates activity of

[Typedef]
id: RO:0011014
name: destabilizes_quantity_of
def: "An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it." []
is_a: RO:0011010 ! directly negatively regulates quantity of

[Typedef]
id: RO:0011015
name: stabilizes_quantity_of
def: "An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it." []
is_a: RO:0011009 ! directly positively regulates quantity of

[Typedef]
id: RO:0011016
name: indirectly_negatively_regulates_activity_of
def: "The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B." []
is_a: RO:0011004 ! indirectly regulates activity of

[Typedef]
id: RO:0011021
name: directly_regulates_quantity_of
def: "The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B." []
is_a: RO:0011003 ! regulates quantity of

[Typedef]
id: RO:0011022
name: indirectly_regulates_quantity_of
def: "The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B." []
is_a: RO:0011003 ! regulates quantity of

[Typedef]
id: RO:0011023
name: indirectly_negatively_regulates_quantity_of
def: "The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B." []
is_a: RO:0011022 ! indirectly regulates quantity of

[Typedef]
id: RO:0011024
name: indirectly_positively_regulates_quantity_of
def: "The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B." []
is_a: RO:0011022 ! indirectly regulates quantity of

[Typedef]
id: RO:0012000
name: has_small_molecule_regulator
def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
is_a: RO:0000057 ! has participant
inverse_of: RO:0012004 ! is small molecule regulator of

[Typedef]
id: RO:0012001
name: has_small_molecule_activator
def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
is_a: RO:0012000 ! has small molecule regulator
inverse_of: RO:0012005 ! is small molecule activator of

[Typedef]
id: RO:0012002
name: has_small_molecule_inhibitor
def: "a relation between a process and a continuant, in which the process is inhibited by the small molecule continuant" []
is_a: RO:0012000 ! has small molecule regulator
inverse_of: RO:0012006 ! is small molecule inhibitor of

[Typedef]
id: RO:0012003
name: acts_on_population_of
def: "p acts on population of c iff c' is a collection, has members of type c, and p has participant c" []
is_a: RO:0000057 ! has participant

[Typedef]
id: RO:0012004
name: is_small_molecule_regulator_of
def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
is_a: RO:0002596 ! capable of regulating

[Typedef]
id: RO:0012005
name: is_small_molecule_activator_of
def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
is_a: RO:0002598 ! capable of positively regulating
is_a: RO:0012004 ! is small molecule regulator of

[Typedef]
id: RO:0012006
name: is_small_molecule_inhibitor_of
def: "a relation between a continuant and a process, in which the continuant is a small molecule that inhibits the process" []
is_a: RO:0002597 ! capable of negatively regulating
is_a: RO:0012004 ! is small molecule regulator of

[Typedef]
id: RO:0012007
name: results_in_adhesion_of
def: "The relationship that links anatomical entities with a process that results in the adhesion of two or more entities via the non-covalent interaction of molecules expressed in, located in, and/or adjacent to, those entities." []
is_a: RO:0040036 ! results in changes to anatomical or cellular structure

[Typedef]
id: RO:0012008
name: results_in_fusion_of
is_a: RO:0002592 ! results in organization of

[Typedef]
id: RO:0012009
name: constitutively_upstream_of
def: "p is constitutively upstream of q iff p is causally upstream of q, p is required for execution of q or a part of q, and the execution of p is approximately constant." []
is_a: RO:0002304 ! causally upstream of, positive effect

[Typedef]
id: RO:0012010
name: removes_input_for
def: "p removes input for q iff p is causally upstream of q, there exists some c such that p has_input c and q has_input c, p reduces the levels of c, and c is rate limiting for execution of q." []
is_a: RO:0002305 ! causally upstream of, negative effect

[Typedef]
id: RO:0012011
name: indirectly_causally_upstream_of
def: "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." []
is_a: RO:0002411 ! causally upstream of

[Typedef]
id: RO:0012012
name: indirectly_regulates
def: "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." []
is_a: RO:0002211 ! regulates
is_a: RO:0012011 ! indirectly causally upstream of

[Typedef]
id: RO:0012013
name: positively_regulates_in_another_organism
def: "x 'positively regulates in other organism' y if and only if: (x is the realization of a function to increase the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." []
synonym: "positively regulates in other organism" EXACT []
is_a: RO:0002010 ! regulates in another organism

[Typedef]
id: RO:0012014
name: negatively_regulates_in_another_organism
def: "x 'negatively regulates in other organism' y if and only if: (x is the realization of a function to reduce the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." []
synonym: "negatively regulates in other organism" EXACT []
is_a: RO:0002010 ! regulates in another organism

[Typedef]
id: RO:0013001
name: has_synaptic_IO_in_region
def: "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region." []
synonym: "has synaptic input or output in" EXACT []
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0013002
name: receives_synaptic_input_in_region
def: "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses in that region." []
is_a: RO:0002110 ! has postsynaptic terminal in
is_a: RO:0013001 ! has synaptic IO in region
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0013003
name: sends_synaptic_output_to_region
def: "A relationship between a neuron and a region, where the neuron has a functionally relevant number of output synapses in that region." []
is_a: RO:0002113 ! has presynaptic terminal in
is_a: RO:0013001 ! has synaptic IO in region
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0013004
name: has_synaptic_IO_throughout
def: "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses distributed throughout that region (rather than confined to a subregion)." []
is_a: RO:0013001 ! has synaptic IO in region

[Typedef]
id: RO:0013005
name: receives_synaptic_input_throughout
def: "A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses distributed throughout that region (rather than confined to a subregion)." []
is_a: RO:0013002 ! receives synaptic input in region
is_a: RO:0013004 ! has synaptic IO throughout

[Typedef]
id: RO:0013006
name: sends_synaptic_output_throughout
def: "A relationship between a neuron and a region, where the neuron has a functionally relevant number output synapses distributed throughout that region (rather than confined to a subregion)." []
is_a: RO:0013003 ! sends synaptic output to region
is_a: RO:0013004 ! has synaptic IO throughout

[Typedef]
id: RO:0013007
name: has_sensory_dendrite_in
def: "Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite." []
synonym: "has sensory dendrite location" EXACT []
synonym: "has sensory terminal in" EXACT []
synonym: "has sensory terminal location" EXACT []
is_a: RO:0002360 ! has dendrite location
transitive_over: BFO:0000050 ! part of

[Typedef]
id: RO:0013008
name: receives_synaptic_input_from_neuron
def: "A relationship between an anatomical structure (including cells) and a neuron that has a functionally relevant number of chemical synapses to it." []
is_a: RO:0002103 ! synapsed by
inverse_of: RO:0013009 ! sends synaptic output to cell

[Typedef]
id: RO:0013009
name: sends_synaptic_output_to_cell
def: "A relationship between a neuron and a cell that it has a functionally relevant number of chemical synapses to." []
is_a: RO:0002120 ! synapsed to

[Typedef]
id: RO:0014001
name: disease_has_infectious_agent
def: "A relationship between a disease and an infectious agent where the material basis of the disease is an infection with some infectious agent." []
is_a: RO:0004019 ! disease has basis in

[Typedef]
id: RO:0015001
name: has_exemplar_data
def: "A relation between a material entity and some data in which the data is taken as exemplifying the material entity." []
inverse_of: RO:0015002 ! exemplar data of
transitive_over: RO:0015003 ! subcluster of

[Typedef]
id: RO:0015002
name: exemplar_data_of

[Typedef]
id: RO:0015003
name: subcluster_of
def: "A relation between a group and another group it is part of but does not fully constitute." []
is_transitive: true
is_a: BFO:0000050 ! part of

[Typedef]
id: RO:0015004
name: has_characterizing_marker_set
def: "A relation that applies between a cell type and a set of markers that can be used to uniquely identify that cell type." []
synonym: "has marker gene combination" EXACT []
synonym: "has marker signature set" EXACT []

[Typedef]
id: RO:0015006
name: different_in_magnitude_relative_to
def: "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165]

[Typedef]
id: RO:0015007
name: increased_in_magnitude_relative_to
def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165]
is_a: RO:0015006 ! different in magnitude relative to

[Typedef]
id: RO:0015008
name: decreased_in_magnitude_relative_to
def: "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165]
is_a: RO:0015006 ! different in magnitude relative to

[Typedef]
id: RO:0015009
name: similar_in_magnitude_relative_to
def: "q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165]

[Typedef]
id: RO:0015010
name: has_relative_magnitude

[Typedef]
id: RO:0015011
name: has_cross_section
def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [https://orcid.org/0000-0002-6601-2165]

[Typedef]
id: RO:0015012
name: reciprocal_of
def: "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." [https://orcid.org/0000-0002-6601-2165]

[Typedef]
id: RO:0015015
name: has_high_plasma_membrane_amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." [PMID:19243617]
is_a: RO:0002104 ! has plasma membrane part

[Typedef]
id: RO:0015016
name: has_low_plasma_membrane_amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." [PMID:19243617]
is_a: RO:0002104 ! has plasma membrane part

[Typedef]
id: RO:0016001
name: has_phenotype_or_disease

[Typedef]
id: RO:0016002
name: has_disease
def: "A relationship that holds between an organism and a disease. Here a disease is construed broadly as a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism." []
is_a: RO:0016001 ! has phenotype or disease

[Typedef]
id: RO:0016004
name: has_exposure_medium
def: "X has exposure medium Y if X is an exposure event (process), Y is a material entity, and the stimulus for X is transmitted or carried in Y." []
is_a: RO:0002244 ! related via exposure to

[Typedef]
id: RO:0017001
name: device_utilizes_material
def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." []
synonym: "utilizes" BROAD []
holds_over_chain: RO:0002215 RO:0002233

[Typedef]
id: RO:0017003
name: positively_correlated_with
def: "A relation between entities in which one increases or decreases as the other does the same." []
is_symmetric: true
is_a: RO:0002610 ! correlated with

[Typedef]
id: RO:0017004
name: negatively_correlated_with
def: "A relation between entities in which one increases as the other decreases." []
is_symmetric: true
is_a: RO:0002610 ! correlated with

[Typedef]
id: RO:0017005
name: contains_measured_amount
def: "A relation between a container and measurement datum that specifies the actual amount of material in the container." []

[Typedef]
id: RO:0018001
name: is_myristoyltransferase_activity
def: "Helper relation for OWL definition of RO:0018002 myristoylates" []
is_a: RO:0002564 ! molecular interaction relation helper property

[Typedef]
id: RO:0018002
name: myristoylates
def: "A molecularly-interacts-with relationship between two entities, where the subject catalyzes a myristoylation activity that takes the object as input" []
is_a: RO:0002436 ! molecularly interacts with
inverse_of: RO:0018003 ! myristoylated by

[Typedef]
id: RO:0018003
name: myristoylated_by
def: "inverse of myristoylates" []

[Typedef]
id: RO:0018027
name: is_agonist_of
def: "a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor activates some activity of the receptor" []
is_a: RO:0002450 ! directly positively regulates activity of

[Typedef]
id: RO:0018028
name: is_inverse_agonist_of
def: "a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor inhibits some activity of the receptor to below basal level" []
is_a: RO:0002449 ! directly negatively regulates activity of

[Typedef]
id: RO:0018029
name: is_antagonist_of
def: "a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor reduces some activity of the receptor to basal level" []
is_a: RO:0002449 ! directly negatively regulates activity of

[Typedef]
id: RO:0018030
name: chemical_relationship

[Typedef]
id: RO:0018031
name: is_direct_conjugate_base_of
def: "A is a direct conjugate base of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by receiving a particular proton transforms it into B." []
is_a: RO:0018033 ! is deprotonated form of
inverse_of: RO:0018032 ! is direct conjugate acid of

[Typedef]
id: RO:0018032
name: is_direct_conjugate_acid_of
def: "A is a direct conjugate acid of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing a particular proton transforms it into B." []
is_a: RO:0018034 ! is protonated form of

[Typedef]
id: RO:0018033
name: is_deprotonated_form_of
def: "A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations." []
is_transitive: true
is_a: RO:0018030 ! chemical relationship
inverse_of: RO:0018034 ! is protonated form of

[Typedef]
id: RO:0018034
name: is_protonated_form_of
def: "A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.\n\nThis is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations." []
is_transitive: true
is_a: RO:0018030 ! chemical relationship

[Typedef]
id: RO:0018035
name: is_matched_small_molecular_pair_with
def: "A and B are a matched small molecular pair (MMP) if their chemical structures define by a single, relatively small, well-defined structural modification.\n\nWhile this is normally called \"matched molecular pair\" in the cheminformatics literaturel, it is labeled as \"matched small molecular pair\" so as to reduce confusion with peptides and other macromolecules, which are also referenced as \"molecules\" in some contexts.\n\nThis relationship is symmetric, meaning if A is a MMP with B iff B is a MMP with A.\n\nThis relationship is not transitive, meaning that A is a MMP with B and B is a MMP with C, then A is not necessarily an MMP with C." [] {http://purl.org/dc/terms/source="https://en.wikipedia.org/wiki/Matched_molecular_pair_analysis", http://purl.org/dc/terms/source="https://doi.org/10.1002/ddr.21045", http://purl.org/dc/terms/source="https://doi.org/10.1021/jm200452d"}
synonym: "is matched molecular pair with" EXACT []
synonym: "is MMP with" EXACT []
is_symmetric: true
is_a: RO:0018030 ! chemical relationship

[Typedef]
id: RO:0018036
name: is_tautomer_of
def: "Two chemicals are tautomers if they can be readily interconverted.\n\nThis commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms." []
synonym: "is desmotrope of" EXACT []
is_symmetric: true
is_a: RO:0018030 ! chemical relationship

[Typedef]
id: RO:0018037
name: is_substitutent_group_from
def: "Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization." []
is_a: RO:0018030 ! chemical relationship

[Typedef]
id: RO:0018038
name: has_functional_parent
def: "Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. \n\nFor example, the relationship between a salt and a freebased compound is a \"has functional parent\" relationship." []
is_a: RO:0018030 ! chemical relationship

[Typedef]
id: RO:0018039
name: is_enantiomer_of
def: "Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.\n\nA chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers)." []
synonym: "is optical isomer of" EXACT []
is_symmetric: true
is_a: RO:0018030 ! chemical relationship

[Typedef]
id: RO:0018040
name: has_parent_hydride
def: "Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B." []
is_a: RO:0018030 ! chemical relationship

[Typedef]
id: RO:0019000
name: regulates_characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." []
holds_over_chain: RO:0002211 RO:0019000
is_a: RO:0002410 ! causally related to

[Typedef]
id: RO:0019001
name: positively_regulates_characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." []
holds_over_chain: RO:0002213 RO:0019001
is_a: RO:0019000 ! regulates characteristic

[Typedef]
id: RO:0019002
name: negatively_regulates_characteristic
def: "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." []
holds_over_chain: RO:0002212 RO:0019001
holds_over_chain: RO:0002213 RO:0019002
is_a: RO:0019000 ! regulates characteristic

[Typedef]
id: RO:0019501
name: confers_susceptibility_to_condition
def: "Relates a gene to condition, such that a variation in this gene predisposes to the development of a condition." []
is_a: RO:0003304 ! contributes to condition

[Typedef]
id: RO:0020101
name: vessel_supplies_blood_to
def: "x vessel supplies blood to y if and only if x is a vessel that supplies blood directly or indirectly to an anatomical structure y." []
is_a: RO:0002178 ! supplies

[Typedef]
id: RO:0020102
name: vessel_drains_blood_from
def: "x vessel drains blood from y if and only if x is a vessel that drains blood directly or indirectly from an anatomical structure y." []
is_a: RO:0002179 ! drains

[Typedef]
id: RO:0020103
name: directly_supplies_and_drains
def: "x directly supplies and drains y if and only if x is a capillary, y is an anatomical entity, and x directly supplies and drains y." []
is_a: RO:0002178 ! supplies
is_a: RO:0002179 ! drains

[Typedef]
id: RO:0040035
name: disease_relationship
def: "This relation groups  relations between diseases and any other kind of entity." []

[Typedef]
id: RO:0040036
name: results_in_changes_to_anatomical_or_cellular_structure
def: "p has anatomical participant c iff p has participant c, and c is an anatomical entity" []
is_a: RO:0000057 ! has participant

[Typedef]
id: RO:HOM0000000
name: in_similarity_relationship_with
def: "Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison." [BGEE:curator, http://purl.obolibrary.org/obo/HOM_0000000]
synonym: "correspondence" RELATED [http://dx.doi.org/10.1007/BF02814479]
synonym: "resemblance" RELATED []
synonym: "sameness" EXACT []
synonym: "similar to" EXACT []
is_symmetric: true

[Typedef]
id: RO:HOM0000001
name: in_homology_relationship_with
def: "Similarity that results from common evolutionary origin." [http://dx.doi.org/10.1002/bies.950180611, http://dx.doi.org/10.1002/jmor.1051730307, http://dx.doi.org/10.1007/BF02814480, http://purl.obolibrary.org/obo/HOM_0000001]
synonym: "homologous to" EXACT []
is_symmetric: true
is_a: RO:0002158 ! shares ancestor with
is_a: RO:HOM0000000 ! in similarity relationship with
disjoint_from: RO:HOM0000002 ! in homoplasy relationship with

[Typedef]
id: RO:HOM0000002
name: in_homoplasy_relationship_with
def: "Similarity that results from independent evolution." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000002]
synonym: "analogy" RELATED []
synonym: "homoplasous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000000 ! in similarity relationship with

[Typedef]
id: RO:HOM0000003
name: in_homocracy_relationship_with
def: "Similarity that is characterized by the organization of anatomical structures through the expression of homologous or identical patterning genes." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1007/s00427-003-0301-4, http://dx.doi.org/10.1186/1742-9994-2-15, http://purl.obolibrary.org/obo/HOM_0000003]
synonym: "homocracous to" EXACT []
is_symmetric: true
is_a: RO:0002320 ! evolutionarily related to
is_a: RO:HOM0000000 ! in similarity relationship with

[Typedef]
id: RO:HOM0000004
name: in_convergence_relationship_with
def: "Homoplasy that involves different underlying mechanisms or structures." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000004]
synonym: "analogy" RELATED []
is_symmetric: true
is_a: RO:HOM0000002 ! in homoplasy relationship with

[Typedef]
id: RO:HOM0000005
name: in_parallelism_relationship_with
def: "Homoplasy that involves homologous underlying mechanisms or structures." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000005]
synonym: "parallel evolution" EXACT []
is_symmetric: true
is_a: RO:HOM0000002 ! in homoplasy relationship with

[Typedef]
id: RO:HOM0000006
name: in_structural_homology_relationship_with
def: "Homology that is defined by similarity with regard to selected structural parameters." [http://dx.doi.org/10.1016/j.jhevol.2006.11.014, http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000006, ISBN:0123195837]
synonym: "idealistic homology" RELATED []
synonym: "structural homologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000001 ! in homology relationship with

[Typedef]
id: RO:HOM0000007
name: in_historical_homology_relationship_with
def: "Homology that is defined by common descent." [http://dx.doi.org/10.1016/S0169-5347(97)01125-7, http://purl.obolibrary.org/obo/HOM_0000007, ISBN:0123195837]
synonym: "cladistic homology" EXACT []
synonym: "historical homologous to" EXACT []
synonym: "homology" BROAD []
synonym: "phylogenetic homology" EXACT []
synonym: "taxic homology" EXACT []
synonym: "true homology" RELATED []
is_symmetric: true
is_a: RO:HOM0000001 ! in homology relationship with

[Typedef]
id: RO:HOM0000008
name: in_biological_homology_relationship_with
def: "Homology that is defined by sharing of a set of developmental constraints, caused by locally acting self-regulatory mechanisms of differentiation, between individualized parts of the phenotype." [http://dx.doi.org/10.1016/S0169-5347(97)01125-7, http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000008]
synonym: "biological homologous to" EXACT []
synonym: "transformational homology" RELATED []
is_symmetric: true
is_a: RO:HOM0000001 ! in homology relationship with

[Typedef]
id: RO:HOM0000009
name: in_reversal_relationship_with
def: "Homoplasy that involves phenotypes similar to those seen in ancestors within the lineage." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000009]
synonym: "atavism" EXACT []
synonym: "reversion" RELATED []
synonym: "rudiment" EXACT []
is_symmetric: true
is_a: RO:HOM0000002 ! in homoplasy relationship with

[Typedef]
id: RO:HOM0000010
name: in_syntenic_homology_relationship_with
def: "Structural homology that is detected by similarity in content and organization between chromosomes." [http://purl.obolibrary.org/obo/HOM_0000010, MeSH:Synteny]
synonym: "syntenic homologous to" EXACT []
synonym: "synteny" RELATED []
is_symmetric: true
is_a: RO:HOM0000006 ! in structural homology relationship with

[Typedef]
id: RO:HOM0000011
name: in_paralogy_relationship_with
def: "Historical homology that involves genes that diverged after a duplication event." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000011, http://www.ncbi.nlm.nih.gov/pubmed/5449325]
synonym: "paralogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with
disjoint_from: RO:HOM0000017 ! in orthology relationship with

[Typedef]
id: RO:HOM0000012
name: in_syntenic_paralogy_relationship_with
def: "Paralogy that involves sets of syntenic blocks." [DOI:10.1002/1097-010X(20001215)288\:4<345\:\:AID-JEZ7>3.0.CO;2-Y, http://dx.doi.org/10.1186/1471-213X-7-100, http://purl.obolibrary.org/obo/HOM_0000012]
synonym: "duplicon" RELATED []
synonym: "paralogon" RELATED []
synonym: "syntenic paralogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000010 ! in syntenic homology relationship with
is_a: RO:HOM0000011 ! in paralogy relationship with

[Typedef]
id: RO:HOM0000013
name: in_syntenic_orthology_relationship_with
def: "Syntenic homology that involves chromosomes of different species." [http://dx.doi.org/10.1101/gr.6380007, http://purl.obolibrary.org/obo/HOM_0000013]
synonym: "syntenic orthologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000010 ! in syntenic homology relationship with

[Typedef]
id: RO:HOM0000014
name: in_partial_homology_relationship_with
def: "Structural homology that involves complex structures from which only a fraction of the elements that can be isolated are separately homologous." [http://purl.obolibrary.org/obo/HOM_0000014, ISBN:0123195837, ISBN:978-0471984931]
synonym: "fractional homology" EXACT []
synonym: "mixed homology" RELATED []
synonym: "modular homology" RELATED []
synonym: "partial correspondence" RELATED []
synonym: "partial homologous to" EXACT []
synonym: "percent homology" RELATED []
synonym: "segmental homology" EXACT []
is_symmetric: true
is_a: RO:HOM0000006 ! in structural homology relationship with

[Typedef]
id: RO:HOM0000015
name: in_protein_structural_homology_relationship_with
def: "Structural homology that is detected at the level of the 3D protein structure, but maybe not at the level of the amino acid sequence." [http://dx.doi.org/10.1016/0022-2836(76)90195-9, http://purl.obolibrary.org/obo/HOM_0000015]
synonym: "protein structural homologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000006 ! in structural homology relationship with

[Typedef]
id: RO:HOM0000016
name: in_non_functional_homology_relationship_with
def: "Structural homology that involves a pseudogenic feature and its functional ancestor." [http://purl.obolibrary.org/obo/HOM_0000016, SO:non_functional_homolog_of]
synonym: "non functional homologous to" EXACT []
synonym: "pseudogene" BROAD []
is_symmetric: true
is_a: RO:HOM0000006 ! in structural homology relationship with
disjoint_from: RO:HOM0000062 ! in equivalogy relationship with

[Typedef]
id: RO:HOM0000017
name: in_orthology_relationship_with
def: "Historical homology that involves genes that diverged after a speciation event." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000017, http://www.ncbi.nlm.nih.gov/pubmed/5449325]
synonym: "orthologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000018
name: in_xenology_relationship_with
def: "Historical homology that is characterized by an interspecies (horizontal) transfer since the common ancestor." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000018]
synonym: "xenologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000019
name: in_1_to_1_homology_relationship_with
def: "Historical homology that involves two members sharing no other homologs in the lineages considered." [BGEE:curator, http://purl.obolibrary.org/obo/HOM_0000019]
synonym: "1 to 1 homologous to" EXACT []
synonym: "1:1 homology" EXACT []
synonym: "one-to-one homology" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000020
name: in_1_to_1_orthology_relationship_with
def: "Orthology that involves two genes that did not experience any duplication after the speciation event that created them." [http://dx.doi.org/10.1007/BF02814484, http://purl.obolibrary.org/obo/HOM_0000020, http://www.ensembl.org/info/docs/compara/homology_method.html]
synonym: "1 to 1 orthologous to" EXACT []
synonym: "1:1 orthology" EXACT []
synonym: "one-to-one orthology" EXACT []
is_symmetric: true
is_a: RO:HOM0000017 ! in orthology relationship with
is_a: RO:HOM0000019 ! in 1 to 1 homology relationship with

[Typedef]
id: RO:HOM0000022
name: in_ohnology_relationship_with
def: "Paralogy that results from a whole genome duplication event." [http://dx.doi.org/10.1038/75560, http://purl.obolibrary.org/obo/HOM_0000022]
synonym: "homoeology" RELATED []
synonym: "ohnologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000011 ! in paralogy relationship with

[Typedef]
id: RO:HOM0000023
name: in_in-paralogy_relationship_with
def: "Paralogy that results from a lineage-specific duplication subsequent to a given speciation event." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000023]
synonym: "in-paralogous to" EXACT []
synonym: "inparalogy" EXACT []
synonym: "symparalogy" EXACT []
is_symmetric: true
is_a: RO:HOM0000011 ! in paralogy relationship with
disjoint_from: RO:HOM0000024 ! in out-paralogy relationship with

[Typedef]
id: RO:HOM0000024
name: in_out-paralogy_relationship_with
def: "Paralogy that results from a duplication preceding a given speciation event." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000024]
synonym: "alloparalogy" EXACT []
synonym: "out-paralogous to" EXACT []
synonym: "outparalogy" EXACT []
is_symmetric: true
is_a: RO:HOM0000011 ! in paralogy relationship with

[Typedef]
id: RO:HOM0000025
name: in_pro-orthology_relationship_with
def: "1:many orthology that involves a gene in species A and one of its ortholog in species B, when duplications more recent than the species split have occurred in species B but not in species A." [http://dx.doi.org/10.1006/scdb.1999.0338, http://dx.doi.org/10.1038/nrg2099, http://purl.obolibrary.org/obo/HOM_0000025]
synonym: "pro-orthologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000034 ! in 1 to many orthology relationship with

[Typedef]
id: RO:HOM0000026
name: in_semi-orthology_relationship_with
def: "1:many orthology that involves a gene in species A and its ortholog in species B, when duplications more recent than the species split have occurred in species A but not in species B." [http://dx.doi.org/10.1006/scdb.1999.0338, http://dx.doi.org/10.1038/nrg2099, http://purl.obolibrary.org/obo/HOM_0000026]
synonym: "semi-orthologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000034 ! in 1 to many orthology relationship with

[Typedef]
id: RO:HOM0000027
name: in_serial_homology_relationship_with
def: "Iterative homology that involves structures arranged along the main body axis." [http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000027]
synonym: "homonomy" RELATED []
synonym: "serial homologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000066 ! in iterative homology relationship with

[Typedef]
id: RO:HOM0000028
name: in_heterochronous_homology_relationship_with
def: "Biological homology that is characterized by changes, over evolutionary time, in the rate or timing of developmental events of homologous structures." [http://purl.obolibrary.org/obo/HOM_0000028, ISBN:978-0674639416]
synonym: "heterochronous homologous to" EXACT []
synonym: "heterochrony" EXACT []
is_symmetric: true
is_a: RO:HOM0000008 ! in biological homology relationship with

[Typedef]
id: RO:HOM0000029
name: in_paedomorphorsis_relationship_with
def: "Heterochronous homology that is produced by a retention in adults of a species of traits previously seen only in juveniles." [http://en.wikipedia.org/wiki/Pedomorphosis, http://purl.obolibrary.org/obo/HOM_0000029, ISBN:978-0674639416]
synonym: "juvenification" EXACT []
synonym: "pedomorphosis" EXACT []
is_symmetric: true
is_a: RO:HOM0000028 ! in heterochronous homology relationship with
disjoint_from: RO:HOM0000030 ! in peramorphosis relationship with

[Typedef]
id: RO:HOM0000030
name: in_peramorphosis_relationship_with
def: "Heterochronous homology that is produced by a maturation of individuals of a species past adulthood, which take on hitherto unseen traits." [http://en.wikipedia.org/wiki/Peramorphosis, http://purl.obolibrary.org/obo/HOM_0000030]
is_symmetric: true
is_a: RO:HOM0000028 ! in heterochronous homology relationship with

[Typedef]
id: RO:HOM0000031
name: in_progenesis_relationship_with
def: "Paedomorphosis that is produced by precocious sexual maturation of an organism still in a morphologically juvenile stage." [http://en.wikipedia.org/wiki/Progenesis, http://purl.obolibrary.org/obo/HOM_0000031, ISBN:978-0674639416]
is_symmetric: true
is_a: RO:HOM0000029 ! in paedomorphorsis relationship with

[Typedef]
id: RO:HOM0000032
name: in_neoteny_relationship_with
def: "Paedomorphosis that is produced by a retardation of somatic development." [http://en.wikipedia.org/wiki/Neoteny, http://purl.obolibrary.org/obo/HOM_0000032, ISBN:978-0674639416]
synonym: "juvenilization" EXACT []
synonym: "neotenous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000029 ! in paedomorphorsis relationship with

[Typedef]
id: RO:HOM0000033
name: in_mimicry_relationship_with
def: "Convergence that results from co-evolution usually involving an evolutionary arms race." [http://en.wikipedia.org/wiki/Mimicry, http://purl.obolibrary.org/obo/HOM_0000033]
synonym: "mimicrous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000004 ! in convergence relationship with

[Typedef]
id: RO:HOM0000034
name: in_1_to_many_orthology_relationship_with
def: "Orthology that involves two genes when duplications more recent than the species split have occurred in one species but not the other." [http://dx.doi.org/10.1038/415741a, http://purl.obolibrary.org/obo/HOM_0000034, http://www.ensembl.org/info/docs/compara/homology_method.html]
synonym: "1 to many orthologous to" EXACT []
synonym: "1:many orthology" EXACT []
synonym: "co-orthology" RELATED []
synonym: "many to 1 orthology" RELATED []
synonym: "one-to-many orthology" EXACT []
is_symmetric: true
is_a: RO:HOM0000017 ! in orthology relationship with
is_a: RO:HOM0000037 ! in 1 to many homology relationship with

[Typedef]
id: RO:HOM0000036
name: in_many_to_many_homology_relationship_with
def: "Historical homology that involves two members of a larger set of homologs." [http://dx.doi.org/10.1093/molbev/msp002, http://purl.obolibrary.org/obo/HOM_0000036]
synonym: "many to many homologous to" EXACT []
synonym: "many-to-many homology" EXACT []
synonym: "many:many homology " EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000037
name: in_1_to_many_homology_relationship_with
def: "Historical homology that involves a structure that has no other homologs in the species in which it is defined, and several homologous structures in another species." [BGEE:curator, http://purl.obolibrary.org/obo/HOM_0000037]
synonym: "1 to many homologous to" EXACT []
synonym: "1:many homology" RELATED []
synonym: "one-to-many homology" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000042
name: in_apomorphy_relationship_with
def: "Historical homology that is based on recent shared ancestry, characterizing a monophyletic group." [http://purl.obolibrary.org/obo/HOM_0000042, ISBN:978-0252068140]
synonym: "apomorphous to" EXACT []
synonym: "synapomorphy" RELATED []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with
disjoint_from: RO:HOM0000043 ! in plesiomorphy relationship with

[Typedef]
id: RO:HOM0000043
name: in_plesiomorphy_relationship_with
def: "Historical homology that is based on distant shared ancestry." [http://purl.obolibrary.org/obo/HOM_0000043, ISBN:978-0252068140]
synonym: "plesiomorphous to" EXACT []
synonym: "symplesiomorphy" RELATED []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000044
name: in_deep_homology_relationship_with
def: "Homocracy that involves morphologically and phylogenetically disparate structures that are the result of parallel evolution." [http://dx.doi.org/10.1007/BF02814485, http://dx.doi.org/10.1038/nature07891, http://purl.obolibrary.org/obo/HOM_0000044]
synonym: "deep genetic homology" EXACT []
synonym: "deep homologous to" EXACT []
synonym: "generative homology" RELATED []
synonym: "homoiology" RELATED []
is_symmetric: true
is_a: RO:HOM0000003 ! in homocracy relationship with
is_a: RO:HOM0000005 ! in parallelism relationship with

[Typedef]
id: RO:HOM0000045
name: in_hemiplasy_relationship_with
def: "Historical homology that is characterized by topological discordance between a gene tree and a species tree attributable to the phylogenetic sorting of genetic polymorphisms across successive nodes in a species tree." [http://dx.doi.org/10.1073/pnas.0807433105, http://purl.obolibrary.org/obo/HOM_0000045]
synonym: "hemiplasous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000046
name: in_gametology_relationship_with
def: "Historical homology that involves not recombining and subsequently differentiated sex chromosomes." [http://purl.obolibrary.org/obo/HOM_0000046, http://www.ncbi.nlm.nih.gov/pubmed/11110898]
synonym: "gametologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000047 ! in chromosomal homology relationship with

[Typedef]
id: RO:HOM0000047
name: in_chromosomal_homology_relationship_with
def: "Historical homology that involves the chromosomes able to pair (synapse) during meiosis." [http://purl.obolibrary.org/obo/HOM_0000047, ISBN:0195307615]
synonym: "chromosomal homologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000048
name: in_many_to_many_orthology_relationship_with
def: "Orthology that involves two genes that experienced duplications more recent than the species split that created them." [http://dx.doi.org/10.1038/415741a, http://purl.obolibrary.org/obo/HOM_0000048, http://www.ensembl.org/info/docs/compara/homology_method.html]
synonym: "co-orthology" RELATED []
synonym: "many to many orthologous to" EXACT []
synonym: "many-to-many orthology" EXACT []
synonym: "many:many orthology" EXACT []
synonym: "trans-homology" RELATED []
synonym: "trans-orthology" EXACT []
is_symmetric: true
is_a: RO:HOM0000017 ! in orthology relationship with
is_a: RO:HOM0000036 ! in many to many homology relationship with

[Typedef]
id: RO:HOM0000049
name: in_within-species_paralogy_relationship_with
def: "Paralogy that involves genes from the same species." [http://purl.obolibrary.org/obo/HOM_0000049, http://www.ensembl.org/info/docs/compara/homology_method.html]
synonym: "within-species paralogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000011 ! in paralogy relationship with
disjoint_from: RO:HOM0000050 ! in between-species paralogy relationship with

[Typedef]
id: RO:HOM0000050
name: in_between-species_paralogy_relationship_with
def: "Paralogy that involves genes from different species." [http://purl.obolibrary.org/obo/HOM_0000050, http://www.ensembl.org/info/docs/compara/homology_method.html]
synonym: "between-species paralogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000011 ! in paralogy relationship with

[Typedef]
id: RO:HOM0000051
name: in_postdisplacement_relationship_with
def: "Paedomorphosis that is produced by delayed growth of immature structures into the adult form." [http://en.wikipedia.org/wiki/Pedomorphosis, http://purl.obolibrary.org/obo/HOM_0000051]
synonym: "post-displacement" EXACT []
is_symmetric: true
is_a: RO:HOM0000029 ! in paedomorphorsis relationship with

[Typedef]
id: RO:HOM0000052
name: in_hypermorphosis_relationship_with
def: "Peramorphosis that is produced by a delay in the offset of development." [http://en.wikipedia.org/wiki/Peramorphosis, http://purl.obolibrary.org/obo/HOM_0000052, ISBN:978-0674639416]
is_symmetric: true
is_a: RO:HOM0000030 ! in peramorphosis relationship with

[Typedef]
id: RO:HOM0000053
name: in_synology_relationship_with
def: "Xenology that results, not from the transfer of a gene between two species, but from a hybridization of two species." [http://dx.doi.org/10.1007/BF00173425, http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://purl.obolibrary.org/obo/HOM_0000053]
synonym: "synologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000018 ! in xenology relationship with

[Typedef]
id: RO:HOM0000054
name: in_isoorthology_relationship_with
def: "Orthology that involves functional equivalent genes with retention of the ancestral function." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://purl.obolibrary.org/obo/HOM_0000054]
synonym: "isoorthologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000017 ! in orthology relationship with
is_a: RO:HOM0000062 ! in equivalogy relationship with

[Typedef]
id: RO:HOM0000055
name: in_tandem_paralogy_relationship_with
def: "Paralogy that is characterized by duplication of adjacent sequences on a chromosome segment." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://purl.obolibrary.org/obo/HOM_0000055, ISBN:978-0878932665]
synonym: "iterative paralogy" RELATED []
synonym: "serial paralogy" RELATED []
synonym: "tandem paralogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000011 ! in paralogy relationship with

[Typedef]
id: RO:HOM0000057
name: in_latent_homology_relationship_with
def: "Parallelism that involves morphologically very similar structures, occurring only within some members of a taxon and absent in the common ancestor (which possessed the developmental basis to develop this character)." [http://dx.doi.org/10.1007/BF02814485, http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://dx.doi.org/10.1186/1742-9994-2-15, http://purl.obolibrary.org/obo/HOM_0000057, ISBN:0199141118]
synonym: "apomorphic tendency" EXACT []
synonym: "cryptic homology" EXACT []
synonym: "homoiology" RELATED []
synonym: "homoplastic tendency" RELATED []
synonym: "latent homologous to" EXACT []
synonym: "re-awakening" RELATED []
synonym: "underlying synapomorphy" EXACT []
is_symmetric: true
is_a: RO:HOM0000005 ! in parallelism relationship with
is_a: RO:HOM0000058 ! in syngeny relationship with

[Typedef]
id: RO:HOM0000058
name: in_syngeny_relationship_with
def: "Homocracy that involves recognizably corresponding characters that occurs in two or more taxa, or as a repeated unit within an individual." [DOI:10.1002/1521-1878(200009)22\:9<846\:\:AID-BIES10>3.0.CO;2-R, http://dx.doi.org/10.1186/1742-9994-2-15, http://purl.obolibrary.org/obo/HOM_0000058]
synonym: "generative homology" EXACT []
synonym: "syngenous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000003 ! in homocracy relationship with

[Typedef]
id: RO:HOM0000060
name: in_apparent_orthology_relationship_with
def: "Between-species paralogy that involves single copy paralogs resulting from reciprocal gene loss." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000060, http://www.ensembl.org/info/docs/compara/homology_method.html]
synonym: "1:1 paralogy" EXACT []
synonym: "apparent 1:1 orthology" EXACT []
synonym: "apparent orthologous to" EXACT []
synonym: "pseudoorthology" EXACT []
is_symmetric: true
is_a: RO:HOM0000019 ! in 1 to 1 homology relationship with
is_a: RO:HOM0000050 ! in between-species paralogy relationship with

[Typedef]
id: RO:HOM0000061
name: in_pseudoparalogy_relationship_with
def: "Xenology that involves genes that ended up in a given genome as a result of a combination of vertical inheritance and horizontal gene transfer." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000061]
synonym: "pseudoparalogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000018 ! in xenology relationship with

[Typedef]
id: RO:HOM0000062
name: in_equivalogy_relationship_with
def: "Historical homology that involves functional equivalent genes with retention of the ancestral function." [http://dx.doi.org/10.1093/nar/gkl1043, http://purl.obolibrary.org/obo/HOM_0000062]
synonym: "equivalogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with
is_a: RO:HOM0000065 ! in functional equivalence relationship with

[Typedef]
id: RO:HOM0000063
name: in_interology_relationship_with
def: "Historical homology that involves orthologous pairs of interacting molecules in different organisms." [http://dx.doi.org/10.1101/gr.1774904, http://dx.doi.org/10.1126/science.287.5450.116, http://purl.obolibrary.org/obo/HOM_0000063]
synonym: "interologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with

[Typedef]
id: RO:HOM0000065
name: in_functional_equivalence_relationship_with
def: "Similarity that is characterized by interchangeability in function." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1038/415741a, http://purl.obolibrary.org/obo/HOM_0000065]
synonym: "functional similarity" RELATED []
is_symmetric: true
is_a: RO:HOM0000000 ! in similarity relationship with

[Typedef]
id: RO:HOM0000066
name: in_iterative_homology_relationship_with
def: "Biological homology that involves parts of the same organism." [http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000066]
synonym: "iterative homologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000008 ! in biological homology relationship with

[Typedef]
id: RO:HOM0000068
name: in_paraxenology_relationship_with
def: "Xenology that is characterized by multiple horizontal transfer events, resulting in the presence of two or more copies of the foreign gene in the host genome." [http://purl.obolibrary.org/obo/HOM_0000068, http://www.ncbi.nlm.nih.gov/pubmed/3065587]
synonym: "duplicate xenology" EXACT []
synonym: "multiple xenology" EXACT []
synonym: "paraxenologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000018 ! in xenology relationship with

[Typedef]
id: RO:HOM0000069
name: in_plerology_relationship_with
def: "Paralogy that is characterized by extra similarity between paralogous sequences resulting from concerted evolution." [http://purl.obolibrary.org/obo/HOM_0000069, http://www.ncbi.nlm.nih.gov/pubmed/3065587]
synonym: "plerologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000011 ! in paralogy relationship with

[Typedef]
id: RO:HOM0000071
name: in_homotopy_relationship_with
def: "Structural homology that involves structures with the same or similar relative positions." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1007/BF02814485, http://purl.obolibrary.org/obo/HOM_0000071, ISBN:0123195837]
synonym: "homotopous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000006 ! in structural homology relationship with
disjoint_from: RO:HOM0000072 ! in homeosis relationship with

[Typedef]
id: RO:HOM0000072
name: in_homeosis_relationship_with
def: "Biological homology that involves an ectopic structure and the normally positioned structure." [http://dx.doi.org/10.1007/BF02814485, http://dx.doi.org/10.1016/j.cell.2008.06.030, http://purl.obolibrary.org/obo/HOM_0000072]
synonym: "heterotopy" RELATED []
is_symmetric: true
is_a: RO:HOM0000008 ! in biological homology relationship with

[Typedef]
id: RO:HOM0000073
name: in_homoeology_relationship_with
def: "Synology that results from allopolyploidy." [http://dx.doi.org/10.1073/pnas.0505156102, http://purl.obolibrary.org/obo/HOM_0000073]
synonym: "homoeologous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000022 ! in ohnology relationship with
is_a: RO:HOM0000053 ! in synology relationship with

[Typedef]
id: RO:HOM0000074
name: in_paramorphism_relationship_with
def: "Iterative homology that involves two structures, one of which originated as a duplicate of the other and co-opted the expression of patterning genes of the ancestral structure." [http://dx.doi.org/10.1007/s10441-007-9023-8, http://dx.doi.org/10.1046/j.1525-142x.2000.00054.x, http://purl.obolibrary.org/obo/HOM_0000074]
synonym: "axis paramorphism" RELATED []
is_symmetric: true
is_a: RO:HOM0000003 ! in homocracy relationship with
is_a: RO:HOM0000066 ! in iterative homology relationship with

[Typedef]
id: RO:HOM0000075
name: in_regulogy_relationship_with
def: "Historical homology that involves orthologous pairs of transcription factors and downstream regulated genes in different organisms." [http://dx.doi.org/10.1101/gr.1774904, http://purl.obolibrary.org/obo/HOM_0000075]
synonym: "regulogous to" EXACT []
is_symmetric: true
is_a: RO:HOM0000007 ! in historical homology relationship with