format-version: 1.2
data-version: releases/2021-04-15
synonymtypedef: abbreviation "abbreviation"
synonymtypedef: layperson "layperson term"
synonymtypedef: obsolete_synonym "discarded/obsoleted synonym"
synonymtypedef: plural_form "plural form"
ontology: scdo
property_value: http://purl.org/dc/elements/1.1/abstract "Sickle cell disease (SCD) is one of the most common monogenic diseases in humans with multiple phenotypic expressions that can manifest as both acute and chronic complications. Although described more than a century ago, challenges in comprehensive disease management and collaborative research on this disease are compounded by the complex molecular and clinical phenotypes of SCD, environmental and psychosocial factors, limited therapeutic options and ambiguous terminology. This ambiguous terminology has hampered the integration and interoperability of existing SCD knowledge, and SCD research translation. The SCD Ontology (SCDO), which is a community-driven integrative and universal knowledge representation system for SCD, overcomes this issue by providing a controlled vocabulary developed by a group of experts in both SCD and ontology design. SCDO is the first and most comprehensive standardized human- and machine-readable resource that unambiguously represents terminology and concepts about SCD for researchers, patients and clinicians. It is built around the central concept ‘hemoglobinopathy’, allowing inclusion of non-SCD haemoglobinopathies, such as thalassaemias, which may interfere with or influence SCD phenotypic manifestations. This collaboratively developed ontology constitutes a comprehensive knowledge management system and standardized terminology of various SCD-related factors. The SCDO will promote interoperability of different research datasets, facilitate seamless data sharing and collaborations, including meta-analyses within the SCD community, and support the development and curation of data-basing and clinical informatics in SCD." xsd:string
property_value: http://purl.org/dc/elements/1.1/accessRights "Anyone can access the resource." xsd:string
property_value: http://purl.org/dc/elements/1.1/accrualMethod "Manually, based on terms in existing ontologies and in collaboration with sickle cell disease (SCD) experts where necessary." xsd:string
property_value: http://purl.org/dc/elements/1.1/accrualPeriodicity "As necessary. Not currently following a fixed frequency." xsd:string
property_value: http://purl.org/dc/elements/1.1/accrualPolicy "Terms/classes are added as they are identified as necessary by the sickle cell disease (SCD) community." xsd:string
property_value: http://purl.org/dc/elements/1.1/audience "Researchers in Hemoglobinopathy and/or sickle cell disease (SCD), SCD patients and clinicians." xsd:string
property_value: http://purl.org/dc/elements/1.1/available "First draft was made available in BioPortal in May 2017" xsd:string
property_value: http://purl.org/dc/elements/1.1/conformsTo "OBO Foundry standards." xsd:string
property_value: http://purl.org/dc/elements/1.1/coverage "The field of sickle cell disease (SCD) research and care." xsd:string
property_value: http://purl.org/dc/elements/1.1/isReferencedBy https://academic.oup.com/database/article/doi/10.1093/database/baz118/5626537
property_value: http://purl.org/dc/elements/1.1/isReferencedBy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947307/
property_value: http://purl.org/dc/elements/1.1/isReferencedBy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411326/
property_value: http://purl.org/dc/elements/1.1/isReferencedBy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549008/
property_value: http://purl.org/dc/elements/1.1/issued "April 2021" xsd:string
property_value: http://purl.org/dc/elements/1.1/language "English" xsd:string
property_value: http://purl.org/dc/elements/1.1/license "GPL-3.0" xsd:string
property_value: http://purl.org/dc/elements/1.1/LicenseDocument https://www.gnu.org/licenses/gpl-3.0.en.html

[Term]
id: APOLLO_SV:00000241
name: Age Range Category
def: "An information content entity specifying the upper and lower limit of a range of ages of continuants." []
xref: APOLLO_SV:00000241
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 APOLLO_SV:00000241
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000403 xsd:string

[Term]
id: ARO:0000006
name: Erythromycin
def: "Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited." []
synonym: "Abomacetin" EXACT []
synonym: "Emgel" EXACT []
synonym: "Eritromicina" EXACT []
synonym: "Erymax" EXACT []
synonym: "Erythrocin" EXACT []
synonym: "Erythromycin A" EXACT []
synonym: "Erythromycine" EXACT []
synonym: "Erythromycinum" EXACT []
synonym: "N-methylerythromycin A" EXACT []
xref: ARO:0000006
is_a: NCIT:C258 ! Antibiotic
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ARO_0000006 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003119 xsd:string

[Term]
id: ARO:0000054
name: Penicillin
def: "Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms." []
synonym: "PCN" EXACT []
synonym: "Penicillins" EXACT []
xref: ARO:0000054
is_a: NCIT:C258 ! Antibiotic
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 ARO:0000054
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000880 xsd:string

[Term]
id: ARO:0000064
name: Amoxycillin
def: "Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan." []
synonym: "Amolin" EXACT []
synonym: "Amopenixin" EXACT []
synonym: "Amoxicilina" EXACT []
synonym: "Amoxicilline" EXACT []
synonym: "Amoxicillinum" EXACT []
synonym: "AMX" EXACT []
synonym: "Clamoxyl" EXACT []
synonym: "D-Amoxicillin" EXACT []
synonym: "Moxal" EXACT []
xref: ARO:0000064
is_a: ARO:0000054 ! Penicillin
relationship: SCDO:1000018 HP:0001081 ! treats Cholelithiasis
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ARO_0000064 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002381 xsd:string

[Term]
id: CHEBI:23888
name: Drug
def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." []
xref: CHEBI:23888
is_a: SCDO:0001152 ! Therapeutics
property_value: SCDO:0000303 "Add sub-class \"Iron Chelator\" with sub-classes \"Deferoxamine\" and \"Deferiprone\" (see wikipedia page for \"Beta Thalassemia\"...mentions how they're used to treat beta thalassemia major).\nAlso add \"Deferoxamine\" and \"Deferiprone\" below \"Iron Chelation Therapy\"." xsd:string
property_value: SCDO:0000340 CHEBI:23888
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000200 xsd:string

[Term]
id: CHEBI:35475
name: Non-Steroidal Anti-Inflammatory Drug
def: "An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." []
synonym: "Non-Steroidal Anti-Inflammatory Agent" EXACT []
xref: CHEBI:35475
is_a: SCDO:0000057 ! Anti-Inflammatory Agent
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_35475 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005809 xsd:string

[Term]
id: CHEBI:35482
name: Opioid
def: "A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood." []
synonym: "Opioid Analgesic" EXACT []
xref: CHEBI:35482
is_a: SCDO:0000050 ! Analgesic
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_35482 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000836 xsd:string

[Term]
id: CHEBI:35493
name: Antipyretic
def: "A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever." []
synonym: "Anti-Pyretic" EXACT []
xref: CHEBI:35493
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_35493 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005335 xsd:string

[Term]
id: CHEBI:42797
name: Gabapentin
def: "A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome." []
synonym: "1-(Aminomethyl)cyclohexaneacetic acid" EXACT []
synonym: "Neurontin" EXACT []
xref: CHEBI:42797
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_42797 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007493 xsd:string

[Term]
id: CHEBI:50858
name: Corticosteroid
def: "A natural or synthetic analogue of the hormones secreted by the adrenal gland." []
synonym: "Corticoides" EXACT []
synonym: "Corticosteroides" EXACT []
synonym: "Corticosteroids" EXACT []
xref: CHEBI:50858
is_a: SCDO:0000057 ! Anti-Inflammatory Agent
property_value: SCDO:0000340 CHEBI:50858
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003901 xsd:string

[Term]
id: CHEBI:5790
name: Hydromorphone
def: "An opioid analgesic derived from morphine and used mainly as an analgesic. It has a shorter duration of action and is more potent than morphine." []
synonym: "3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one" EXACT []
xref: CHEBI:5790
is_a: CHEBI:35482 ! Opioid
property_value: SCDO:0000340 http://www.drugbank.ca/drugs/DB00327 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000577 xsd:string

[Term]
id: CHEBI:60809
name: Adjuvant
def: "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." []
synonym: "Adjuvant Medicine" EXACT []
xref: CHEBI:60809
is_a: SCDO:0001152 ! Therapeutics
relationship: SCDO:1000015 NCIT:C39547 ! modifies Treatment Efficacy
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_60809 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000025 xsd:string

[Term]
id: CHEBI:6807
name: Methadone
def: "A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence." []
synonym: "6-(dimethylamino)-4,4-diphenylheptan-3-one" EXACT []
synonym: "Physeptone" EXACT []
xref: CHEBI:6807
is_a: CHEBI:35482 ! Opioid
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://www.drugbank.ca/drugs/DB00333 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000752 xsd:string

[Term]
id: CHEBI:6909
name: Metronidazole
def: "A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death." []
synonym: "Satric" EXACT []
synonym: "Trichazol" EXACT []
xref: CHEBI:6909
is_a: NCIT:C258 ! Antibiotic
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1000018 HP:0001081 ! treats Cholelithiasis
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_6909 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002912 xsd:string

[Term]
id: CHEBI:7852
name: Oxycodone
def: "A semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine." []
comment: An extended-release (ER) form of oxycodone (Xtampza ER) was approved for the management of daily, around-the-clock pain management in April, 2016.
synonym: "14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one" EXACT []
synonym: "Dihydrone" EXACT []
xref: CHEBI:7852
is_a: CHEBI:35482 ! Opioid
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://www.drugbank.ca/drugs/DB00497 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000847 xsd:string

[Term]
id: CHMO:0001009
name: High-Performance Liquid Chromatography
def: "Column chromatography where the mobile phase is a liquid, the stationary phase consists of very small particles and the inlet pressure is relatively high." []
synonym: "High Performance Liquid Chromatography" EXACT []
synonym: "High Pressure Liquid Chromatography" EXACT []
synonym: "High-Pressure Liquid Chromatography" EXACT []
synonym: "HPLC" EXACT []
xref: CHMO:0001009
is_a: SCDO:0000216 ! Chemical Assay
is_a: SCDO:1000577 ! Type of SCD Test
property_value: http://purl.org/dc/elements/1.1/source http://labtestsonline.org/understanding/analytes/hemoglobin-var/tab/test/
property_value: SCDO:0000303 "Perhaps change label to \"Hemoglobin by High Performance Liquid Chromatography\"? See dc:source provided." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHMO_0001009 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000563 xsd:string

[Term]
id: CHMO:0002580
name: Colorimetric Test
def: "A test which produces colour change in the sample." []
xref: CHMO:0002580
is_a: SCDO:0000120 ! Biochemical Assay
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHMO_0002580 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000264 xsd:string

[Term]
id: CMO:0000001
name: Cardiovascular Measurement
def: "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels." []
xref: CMO:0000001
is_a: SCDO:0000728 ! Diagnostic Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000001 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000186 xsd:string

[Term]
id: CMO:0000003
name: Blood Pressure Measurement
def: "Measurement of the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood." []
xref: CMO:0000003
is_a: CMO:0000001 ! Cardiovascular Measurement
relationship: SCDO:1000193 SCDO:0001097 ! output of diagnostic device Sphygmomanometer
property_value: SCDO:0000303 "There are many more specific sub-classes in the CMO. Are there any we want to include here?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000003 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000144 xsd:string

[Term]
id: CMO:0000011
name: Whole Body Morphological Measurement
def: "Morphological measurement involving the entire body of an organism." []
xref: CMO:0000011
is_a: CMO:0000021 ! Body Morphological Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000011 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001245 xsd:string

[Term]
id: CMO:0000015
name: Body Temperature
def: "The level of heat in an organism." []
xref: CMO:0000015
is_a: SCDO:0000728 ! Diagnostic Measurement
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 OBI:0002140 ! obtained via diagnostic tool Temperature Measurement Assay
relationship: SCDO:1000772 MP:0005533 ! has possible finding Increased Body Temperature
relationship: SCDO:1000772 MP:0005534 ! has possible finding Decreased Body Temperature
property_value: SCDO:0000340 CMO:0000015
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000151 xsd:string

[Term]
id: CMO:0000021
name: Body Morphological Measurement
def: "Measurement of the structure or forms of the entire body or parts of the body of an organism." []
synonym: "Anthropometric Measurement" EXACT []
synonym: "Anthropometrics" EXACT []
synonym: "Morphometry" EXACT []
xref: CMO:0000021
is_a: SCDO:0000728 ! Diagnostic Measurement
property_value: SCDO:0000303 "Include the term \"Body Composition\" from PhenX? --  -- Any other relevant terms missing as sub-classes here?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000021 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000150 xsd:string

[Term]
id: CMO:0000023
name: Blood Chemistry Measurement
def: "A quantification of a parameter of the chemical composition of blood." []
xref: CMO:0000023
is_a: CMO:0000035 ! Blood Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000023 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000136 xsd:string

[Term]
id: CMO:0000025
name: Red Blood Cell Count
def: "The number of red blood cells in a specified volume of blood most commonly 1 cubic millimeter (i.e. 1 microliter) of peripheral venous blood." []
synonym: "Erythrocyte Count" EXACT []
synonym: "Erythrocyte Number" EXACT []
synonym: "Erythrocyte Numbers" EXACT []
synonym: "Red Blood Count" EXACT []
xref: CMO:0000025
is_a: CMO:0001356 ! Red Blood Cell Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000193 SCDO:0000504 ! output of diagnostic device Hematology Analyzer
relationship: SCDO:1000772 HP:0020059 ! has possible finding Increased Red Blood Cell Count
relationship: SCDO:1000772 HP:0020060 ! has possible finding Decreased Red Blood Cell Count
relationship: SCDO:1000772 SCDO:1000822 ! has possible finding Normal Red Blood Cell Count
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000025 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000973 xsd:string

[Term]
id: CMO:0000027
name: White Blood Cell Count
def: "The number of white blood cells in a specified volume of blood." []
synonym: "Leukocyte Count" EXACT []
synonym: "White Corpuscle Count" EXACT []
xref: CMO:0000027
is_a: CMO:0002341 ! White Blood Cell Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000193 SCDO:0000504 ! output of diagnostic device Hematology Analyzer
relationship: SCDO:1000772 HP:0001882 ! has possible finding Leukopenia
relationship: SCDO:1000772 HP:0001974 ! has possible finding Leukocytosis
relationship: SCDO:1000772 SCDO:1000823 ! has possible finding Normal White Blood Cell Count
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000027 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001243 xsd:string

[Term]
id: CMO:0000029
name: Platelet Count
def: "The number of platelets (thrombocytes) in a specified volume of blood, usually expressed as platelets per cubic millimeter of whole blood." []
synonym: "Blood Platelet count" EXACT []
synonym: "Blood Platelet Number" EXACT []
synonym: "Platelet Number" EXACT []
xref: CMO:0000029
is_a: CMO:0000921 ! Platelet Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000193 SCDO:0000504 ! output of diagnostic device Hematology Analyzer
relationship: SCDO:1000772 HP:0001873 ! has possible finding Thrombocytopenia
relationship: SCDO:1000772 HP:0001894 ! has possible finding Thrombocytosis
relationship: SCDO:1000772 SCDO:1000824 ! has possible finding Normal Platelet Count
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000029 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000906 xsd:string

[Term]
id: CMO:0000030
name: Blood Neutrophil Count
def: "The number of granulocytes categorized as neutrophils in a specified volume of blood. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes." []
synonym: "Neutrophil Granulocyte Count" EXACT []
xref: CMO:0000030
is_a: CMO:0000111 ! Blood Granulocyte Count
property_value: SCDO:0000340 CMO:0000030
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000442 xsd:string

[Term]
id: CMO:0000035
name: Blood Measurement
def: "A measurement of the blood, it's contents, cells or other factors contained within the blood." []
xref: CMO:0000035
is_a: SCDO:0000728 ! Diagnostic Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000035 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000143 xsd:string

[Term]
id: CMO:0000036
name: Blood Cell Measurement
def: "A value resulting from the quantification of a morphological or physiological parameter of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning." []
xref: CMO:0000036
is_a: CMO:0000035 ! Blood Measurement
property_value: SCDO:0000303 "Perhaps include missing sub-classes of \"Blood Cell Measurement\" from the Clinical Measurement Ontology?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000036 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000135 xsd:string

[Term]
id: CMO:0000037
name: Hematocrit
def: "Percentage of total blood volume that is made up of red blood cells." []
synonym: "Hct" EXACT []
synonym: "Packed Cell Volume" EXACT []
synonym: "Packed Red Blood Cell Volume" EXACT []
xref: CMO:0000037
is_a: CMO:0001356 ! Red Blood Cell Measurement
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000037 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000503 xsd:string

[Term]
id: CMO:0000038
name: Mean Corpuscular Volume
def: "A measure of the average volume or size of a single red blood cell. It is derived by dividing the total volume of packed red blood cells by the total red blood cell count." []
synonym: "MCV" EXACT []
synonym: "Mean Cell Volume" EXACT []
xref: CMO:0000038
is_a: CMO:0001356 ! Red Blood Cell Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000772 HP:0005518 ! has possible finding Increased Mean Corpuscular Volume
relationship: SCDO:1000772 HP:0025066 ! has possible finding Decreased Mean Corpuscular Volume
relationship: SCDO:1000772 SCDO:1000825 ! has possible finding Normal Mean Corpuscular Volume
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000038 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000723 xsd:string

[Term]
id: CMO:0000057
name: Serum Creatinine Level
def: "The amount of creatinine, a catabolic product of creatine phosphate used in skeletal muscle contraction found in a specified volume of serum." []
synonym: "Creatinine Level" EXACT []
xref: CMO:0000057
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000567 ! has essential measure History of Kidney Failure Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000570 ! has essential measure History of Type I and Type 2 Diabetes Diagnostic Instrument
relationship: SCDO:1000190 SCDO:0000296 ! obtained via diagnostic tool Creatinine Blood Test
relationship: SCDO:1000772 HP:0012101 ! has possible finding Decreased Serum Creatinine
relationship: SCDO:1000772 SCDO:1000649 ! has possible finding Elevated Serum Creatinine
relationship: SCDO:1000772 SCDO:1000829 ! has possible finding Normal Serum Creatinine
property_value: SCDO:0000303 "Link to \"Glomerular Filtration Rate\"... which object property? Create a new one and suggest to RO? \"used to calculate\"?" xsd:string
property_value: SCDO:0000340 CMO:0000057
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001042 xsd:string

[Term]
id: CMO:0000094
name: Respiratory System Measurement
def: "A measurement to assess the morphological or physiological state of the respiratory system or portion of the respiratory system." []
xref: CMO:0000094
is_a: SCDO:0000728 ! Diagnostic Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000094 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000995 xsd:string

[Term]
id: CMO:0000111
name: Blood Granulocyte Count
def: "The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter." []
xref: CMO:0000111
is_a: CMO:0000366 ! Blood Differential White Blood Cell Count
property_value: SCDO:0000340 CMO:0000111
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000441 xsd:string

[Term]
id: CMO:0000123
name: Blood Bilirubin Level
def: "The amount of bilirubin found in a specific volume of blood." []
synonym: "Bilirubin Level" EXACT []
xref: CMO:0000123
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000119 ! obtained via diagnostic tool Bilirubin Blood Test
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000123 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000134 xsd:string

[Term]
id: CMO:0000195
name: Blood Flow Measurement
def: "Any measurement of the movement of blood through the heart and blood vessels." []
synonym: "Circulation Measurement" EXACT []
xref: CMO:0000195
is_a: CMO:0000001 ! Cardiovascular Measurement
property_value: SCDO:0000303 "Add any more from below \"circulation measurement\" in the CMO?\nSuggest to CMO  \"Blood Flow Measurement\" be an exact synonym of \"Circulation Measurement\", as we have made it here.\nSuggest to CRISP that their \"blood flow measurement\" instead be \"Blood Flow Test\"." xsd:string
property_value: SCDO:0000340 CMO:0000195
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000142 xsd:string

[Term]
id: CMO:0000204
name: Blood Coagulation Measurement
def: "Measurement to assess the sequential process through which multiple factors of the blood interact to form an insoluble fibrin clot." []
xref: CMO:0000204
is_a: CMO:0000035 ! Blood Measurement
property_value: SCDO:0000303 "Add other sub-classes of \"Blood Coagulation Measurement\" from the CMO?\nblood fibrinogen level?\nthrombin time?\nactivated clotting time (ACT)?\nplatelet aggregation measurement?\nbleeding time (BT)?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000204 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000137 xsd:string

[Term]
id: CMO:0000210
name: Activated Partial Thromboplastin Time
def: "The time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent. It is used to evaluate the intrinsic clotting system." []
synonym: "APTT; Quick" EXACT []
xref: CMO:0000210
is_a: CMO:0000204 ! Blood Coagulation Measurement
property_value: SCDO:0000340 CMO:0000210
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000014 xsd:string

[Term]
id: CMO:0000211
name: Prothrombin Time
def: "Measurement of the clotting ability of fibrinogen, prothrombin, proaccelerin, proconvertin and Stuart factor, usually given in seconds to formation of clot after the addition of a tissue factor or thromboplastin." []
synonym: "PTT" EXACT []
xref: CMO:0000211
is_a: CMO:0000204 ! Blood Coagulation Measurement
property_value: SCDO:0000340 CMO:0000211
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000933 xsd:string

[Term]
id: CMO:0000225
name: Arterial Blood Gas Measurement
def: "Any measurement of a gas or gases dissolved in arterial blood, that is, blood which has absorbed oxygen in the lungs, including oxygen, nitrogen carbon dioxide and/or hydrogen." []
xref: CMO:0000225
is_a: CMO:0001321 ! Blood Gas Measurement
property_value: SCDO:0000340 CMO:0000225
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000718 xsd:string

[Term]
id: CMO:0000256
name: Urine Measurement
def: "Any measurement of urine, the fluid waste product excreted by the kidneys, or its components." []
xref: CMO:0000256
is_a: SCDO:0000728 ! Diagnostic Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000256 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001214 xsd:string

[Term]
id: CMO:0000283
name: Partial Pressure of Carbon Dioxide
def: "The force per unit area attributable to the carbon dioxide, a colorless, odorless, incombustible gas formed during respiration and composed of one atom of carbon and two atoms of oxygen, dissolved in a specified volume of blood, defined as the force per unit area exerted by carbon dioxide in a mixture of gases in equilibrium with such a sample of blood at the same temperature." []
synonym: "PaCO2" EXACT []
synonym: "Partial Pressure of Blood Carbon Dioxide" EXACT []
synonym: "Partial Pressure of Blood Carbon Dioxide (Pco2)" EXACT []
synonym: "Partial Pressure of Carbon Dioxide (PaCO2)" EXACT []
synonym: "Pco2" EXACT []
xref: CMO:0000283
is_a: CMO:0000225 ! Arterial Blood Gas Measurement
relationship: SCDO:1000190 SCDO:0000071 ! obtained via diagnostic tool Arterial Blood Gas Test
relationship: SCDO:1000772 SCDO:1000839 ! has possible finding Normal Partial Pressure of Carbon Dioxide
relationship: SCDO:1000772 SCDO:1000840 ! has possible finding Decreased Partial Pressure of Carbon Dioxide
relationship: SCDO:1000772 SCDO:1000841 ! has possible finding Increased Partial Pressure of Carbon Dioxide
property_value: SCDO:0000340 CMO:0000283
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000719 xsd:string

[Term]
id: CMO:0000290
name: Mean Corpuscular Hemoglobin Level
def: "The average amount of hemoglobin per red blood cell calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood." []
synonym: "MCH" EXACT []
synonym: "Mean Cell Hemoglobin" EXACT []
synonym: "Mean Cell Hemoglobin Level" EXACT []
synonym: "Mean Corpuscular Haemoglobin" EXACT []
synonym: "Mean Corpuscular Haemoglobin Level" EXACT []
synonym: "Mean Corpuscular Hemoglobin" EXACT []
xref: CMO:0000290
is_a: CMO:0001356 ! Red Blood Cell Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000772 MP:0005561 ! has possible finding Increased Mean Corpuscular Hemoglobin
relationship: SCDO:1000772 MP:0005562 ! has possible finding Decreased Mean Corpuscular Hemoglobin
relationship: SCDO:1000772 SCDO:1000826 ! has possible finding Normal Mean Corpuscular Hemoglobin
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000290 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000722 xsd:string

[Term]
id: CMO:0000291
name: Mean Corpuscular Hemoglobin Concentration
def: "The amount of hemoglobin in a given volume of packed red blood cells and is often calculated by dividing the hemoglobin concentration by the hematocrit." []
synonym: "MCHC" EXACT []
synonym: "Mean Cell Hemoglobin Concentration" EXACT []
synonym: "Mean Corpuscular Haemoglobin Concentration" EXACT []
xref: CMO:0000291
is_a: CMO:0001356 ! Red Blood Cell Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000772 HP:0025547 ! has possible finding Decreased Mean Corpuscular Hemoglobin Concentration
relationship: SCDO:1000772 HP:0025548 ! has possible finding Increased Mean Corpuscular Hemoglobin Concentration
relationship: SCDO:1000772 SCDO:1000827 ! has possible finding Normal Mean Corpuscular Hemoglobin Concentration
property_value: SCDO:0000303 "Add the sub-class \"mean corpuscular sickle hemoglobin concentration (MCSHC)\"? (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC290884/pdf/jcinvest00309-0076.pdf)" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000291 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000721 xsd:string

[Term]
id: CMO:0000364
name: Complete Blood Count
def: "The calculation of the cellular elements of the blood, usually including cell counts for white and red blood cells and platelets." []
synonym: "Blood Cell Count" EXACT []
synonym: "Blood Cell Number" EXACT []
synonym: "CBC" EXACT []
synonym: "FBC" EXACT []
synonym: "Full Blood Count" EXACT []
xref: CMO:0000364
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000740 ! has essential measure Medication Inventory
relationship: SCDO:0001297 SCDO:1000342 ! has essential measure History of Transfusion Diagnostic Instrument
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000364 xsd:string
property_value: SCDO:0000479 CBC:J.htm
property_value: SCDO:0000479 "PhenX protocol: Complete Blood Count #220501" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000270 xsd:string

[Term]
id: CMO:0000365
name: Total White Blood Cell Count
def: "The total number of leukocytes in 1 cubic millimeter of peripheral venous blood." []
xref: CMO:0000365
is_a: CMO:0000027 ! White Blood Cell Count
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000365 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001163 xsd:string

[Term]
id: CMO:0000366
name: Blood Differential White Blood Cell Count
def: "The number of each type of leukocyte present in a specific volume of blood, usually 1 cubic millimeter." []
synonym: "Blood Differential Leukocyte Count" EXACT []
synonym: "Blood Differential WBC Count" EXACT []
synonym: "WBC Differential Count" EXACT []
xref: CMO:0000366
is_a: CMO:0000027 ! White Blood Cell Count
property_value: SCDO:0000303 "Perhaps add sub-classes from \"Clinical Measurement Ontology\"?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000366 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000140 xsd:string

[Term]
id: CMO:0000376
name: Total Serum Bilirubin Level
def: "The complete or entire amount of bilirubin in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Bilirubin is the bile pigment produced by breakdown of heme and reduction of biliverdin." []
xref: CMO:0000376
is_a: CMO:0000123 ! Blood Bilirubin Level
relationship: SCDO:1000190 SCDO:0000119 ! obtained via diagnostic tool Bilirubin Blood Test
relationship: SCDO:1000772 HP:0003573 ! has possible finding Increased Total Bilirubin
relationship: SCDO:1000772 SCDO:1000835 ! has possible finding Normal Total Serum Bilirubin
property_value: SCDO:0000340 CMO:0000376
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000500 xsd:string

[Term]
id: CMO:0000506
name: Hemoglobin Concentration
def: "The amount of hemoglobin, the red oxygen-carrying pigment of erythrocytes, in a specified volume of blood, as calculated from the optical density of a solution of lysed red cells in which hemoglobin has been converted to cyanomethemoglobin and measured with a spectrophotometer." []
synonym: "ctHB" EXACT []
synonym: "Hbtotal" EXACT []
synonym: "Hemoglobin Level" EXACT []
synonym: "Total Hemoglobin" EXACT []
synonym: "Total Hemoglobin (Hbtotal)" EXACT []
xref: CMO:0000506
is_a: CMO:0000508 ! Hemoglobin Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000190 SCDO:0000071 ! obtained via diagnostic tool Arterial Blood Gas Test
relationship: SCDO:1000772 HP:0020062 ! has possible finding Decreased Hemoglobin Concentration
relationship: SCDO:1000772 HP:0020063 ! has possible finding Increased Hemoglobin Concentration
relationship: SCDO:1000772 SCDO:1000783 ! has possible finding Normal Hemoglobin Concentration
property_value: SCDO:0000340 CMO:0000506
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000523 xsd:string

[Term]
id: CMO:0000507
name: Hemoglobin Absorbance
def: "The optical density as calculated from the intensity of light at a specified wavelength as it passes through a solution of lysed red blood cells." []
xref: CMO:0000507
is_a: CMO:0000508 ! Hemoglobin Measurement
property_value: SCDO:0000340 CMO:0000507
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000249 xsd:string

[Term]
id: CMO:0000508
name: Hemoglobin Measurement
def: "A measure of the oxygen carrying pigment of erythrocytes." []
xref: CMO:0000508
is_a: CMO:0000036 ! Blood Cell Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000508 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000543 xsd:string

[Term]
id: CMO:0000665
name: Heart Contraction Pressure
def: "Pressure exerted by the heart muscle in its maximally contracted state." []
xref: CMO:0000665
is_a: SCDO:1000317 ! Heart Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000665 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000499 xsd:string

[Term]
id: CMO:0000921
name: Platelet Measurement
def: "Any measurement of platelets, the disk-shaped structures found in the blood of mammals which play a vital role in blood coagulation. Platelets lack nuclei and DNA but contain active enzymes and mitochondria." []
xref: CMO:0000921
is_a: CMO:0000036 ! Blood Cell Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000921 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000907 xsd:string

[Term]
id: CMO:0001321
name: Blood Gas Measurement
def: "Any measurement of a gas or gases dissolved in the blood, including oxygen, nitrogen carbon dioxide and/or hydrogen." []
xref: CMO:0001321
is_a: CMO:0000035 ! Blood Measurement
property_value: SCDO:0000340 CMO:0001321
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000312 xsd:string

[Term]
id: CMO:0001324
name: Oxygen Saturation
def: "The amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity." []
synonym: "HbO2" EXACT []
synonym: "Oxyhemoglobin Saturation" EXACT []
synonym: "Oxyhemoglobin Saturation (HbO2)" EXACT []
synonym: "SaO2" EXACT []
synonym: "Sats" EXACT []
synonym: "SO2" EXACT []
xref: CMO:0001324
is_a: CMO:0001321 ! Blood Gas Measurement
property_value: SCDO:0000340 CMO:0001324
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000848 xsd:string

[Term]
id: CMO:0001356
name: Red Blood Cell Measurement
def: "Any measurement of a single red blood cell, one of the hemoglobin-containing blood cells that transport oxygen and carbon dioxide to and from the tissues, or of all of the red blood cells in a sample of blood." []
synonym: "Erythrocyte Measurement" EXACT []
xref: CMO:0001356
is_a: CMO:0000036 ! Blood Cell Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0001356 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000974 xsd:string

[Term]
id: CMO:0002079
name: Birth Weight
def: "The heaviness or degree to which the entire body of an organism at the point of or shortly after birth is drawn to the earth by gravity." []
synonym: "Body Weight of Neonate" EXACT []
synonym: "Neonatal Body Weight" EXACT []
xref: CMO:0002079
is_a: SCDO:0000152 ! Body Weight
property_value: SCDO:0000340 CMO:0002079
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000311 xsd:string

[Term]
id: CMO:0002341
name: White Blood Cell Measurement
def: "Any value resulting from the quantification of a morphological or physiological parameter of leukocytes, largely colorless blood corpuscles capable of ameboid movement, whose chief function is to protect the body against microorganisms and other disease-causing entities." []
xref: CMO:0002341
is_a: CMO:0000036 ! Blood Cell Measurement
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0002341 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001244 xsd:string

[Term]
id: CMO:0002520
name: Serum Haptoglobin Level
def: "Measurement of the amount of haptoglobin in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Haptoglobin is a serum alpha2 globulin glycoprotein, produced by the liver, that functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin." []
synonym: "Haptoglobin Level" EXACT []
synonym: "Haptoglobin Levels" EXACT []
xref: CMO:0002520
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000466 ! obtained via diagnostic tool Haptoglobin Blood Test
property_value: SCDO:0000340 CMO:0002520
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000467 xsd:string

[Term]
id: CMO:0002876
name: N-Terminal Pro-Brain Natriuretic Peptide Level
def: "The amount of N-terminal (NT)-pro hormone BNP (Nppb) in a specified volume of blood." []
synonym: "Blood NH2-Terminal pro-B-Type Natriuretic Peptide Level" EXACT []
synonym: "BNPT Level" EXACT []
synonym: "N-Terminal Prohormone of Brain Natriuretic Peptide Level" EXACT []
synonym: "NT-proBNP Level" EXACT []
synonym: "NT-proBNP Measurement" EXACT []
xref: CMO:0002876
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000787 ! obtained via diagnostic tool N-terminal Pro-brain Natriuretic Peptide Test
property_value: SCDO:0000303 "Value given as 1 Decimal Place Nanogram per Liter (according to PhenX https://www.phenxtoolkit.org/protocols/view/810501)\n\nassociated with acute congestive heart failure (http://www.ebi.ac.uk/efo/EFO_0004745)" xsd:string
property_value: SCDO:0000340 CMO:0002876
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000786 xsd:string

[Term]
id: DOID:0050731
name: Vitamin B12 Deficiency
def: "A vitamin metabolic disorder that results from low blood levels of vitamin B12." []
synonym: "Cobalamin Deficiency" EXACT []
synonym: "Hypocobalaminemia" EXACT []
xref: DOID:0050731
is_a: SCDO:1000261 ! Avitaminosis
property_value: SCDO:0000340 DOID:0050731
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005733 xsd:string

[Term]
id: DOID:0060181
name: Ischemic Cholitis
def: "A colitis caused by inadequate blood supply to the colon." []
xref: DOID:0060181
is_a: HP:0025031 ! Abnormality of the Digestive System
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
property_value: SCDO:0000303 "Is diagnosed by: abdominal computed tomography scan" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/DOID_0060181 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002870 xsd:string

[Term]
id: DOID:0111033
name: African Iron Overload
def: "A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums." []
synonym: "Bantu Siderosis" EXACT []
synonym: "Iron Overload in Africa" EXACT []
xref: DOID:0111033
is_a: SCDO:1000281 ! Secondary Hemochromatosis
property_value: SCDO:0000340 DOID:0111033
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000282 xsd:string

[Term]
id: DOID:1188
name: Mononeuropathy
def: "A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve." []
synonym: "Single Damaged Nerve" EXACT []
xref: DOID:1188
is_a: HP:0012639 ! Abnormal Nervous System Morphology
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000963 ! diagnosed using tool Radiography
relationship: SCDO:0000664 SCDO:0000822 ! treated with Occupational Therapy
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 DOID:1188
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000769 xsd:string

[Term]
id: DOID:1584
name: Acute Chest Syndrome
def: "A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion." []
comment: From the DO: The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.
synonym: "Acute Chest Syndrome in Sickle Cell Disease" EXACT []
xref: DOID:1584
is_a: HP:0002086 ! Abnormality of the Respiratory System
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000217 ! diagnosed using tool Chest X-Ray
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 NCIT:C15238 ! treated with Gene Therapy
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:0000664 SCDO:0000576 ! treated with Hydration Therapy
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "This definition was given by the WG: 'Acute onset of respiratory symptoms and/or signs and an X-ray consistent with alveolar consolidation but not atelectasis, involving at least one complete lung segment.\" With this definition source:The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. O. Castro, D. J. Brambilla, B. Thorington, C. A. Reindorf, R. B. Scott, P. Gillette, J. C. Vera, P. S. Levy Blood. 1994 Jul 15; 84(2): 643–649.\nHowever, the definition did not seem to come from this source, so the DO term was used instead." xsd:string
property_value: SCDO:0000340 DOID:1584
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000015 xsd:string

[Term]
id: DOID:1826
name: Epilepsy
def: "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." []
xref: DOID:1826
is_a: HP:0000708 ! Behavioural Abnormality
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/DOID_1826 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008484 xsd:string

[Term]
id: DOID:2326
name: Gastroenteritis
def: "A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen." []
xref: DOID:2326
is_a: IDO:0000586 ! Infection
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/DOID_2326 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007198 xsd:string

[Term]
id: DOID:4
name: Disease
def: "A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism." []
xref: DOID:4
is_a: SCDO:0001000 ! SCDO
relationship: SCDO:1000015 NCIT:C17047 ! modifies Quality of Life
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/DOID_4 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001365 xsd:string

[Term]
id: DOID:813
name: Septic Arthritis
def: "An arthritis that involves infection by a pathogen located in a joint." []
synonym: "Infected Joint" EXACT []
synonym: "Infectious Arthritis" EXACT []
xref: DOID:813
is_a: HP:0000924 ! Abnormality of the Skeletal System
is_a: IDO:0000586 ! Infection
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/DOID_813 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002067 xsd:string

[Term]
id: DOID:9220
name: Central Sleep Apnea
def: "A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing." []
synonym: "Primary Central Sleep Apnea" EXACT []
xref: DOID:9220
is_a: HP:0000708 ! Behavioural Abnormality
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/DOID_9220 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000200 xsd:string

[Term]
id: DRON:00017565
name: Xylometazoline
def: "A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion." []
synonym: "Balminil" EXACT []
synonym: "Otrivin" EXACT []
synonym: "Xylomethazoline" EXACT []
xref: DRON:00017565
is_a: SCDO:0000791 ! Nasal Decongestants
property_value: SCDO:0000340 http://www.drugbank.ca/drugs/DB06694 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001254 xsd:string

[Term]
id: DUO:0000018
name: Not for Profit Use Only
def: "This requirement indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use." []
xref: DUO:0000018
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000018
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000413 xsd:string

[Term]
id: DUO:0000019
name: Publication Required
def: "This requirement indicates that requestor agrees to make results of studies using the data available to the larger scientific community." []
xref: DUO:0000019
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000019
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000416 xsd:string

[Term]
id: DUO:0000020
name: Collaboration Required
def: "This could be coupled with a string describing the primary study investigator(s)." []
xref: DUO:0000020
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000020
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000409 xsd:string

[Term]
id: DUO:0000021
name: Ethics Approval Required
def: "This requirement indicates that the requestor must provide documentation of local IRB/ERB approval." []
xref: DUO:0000021
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000021
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000410 xsd:string

[Term]
id: DUO:0000022
name: Geographical Restriction
def: "This should be coupled with an ontology term describing the geographical location the restriction applies to." []
xref: DUO:0000022
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000022
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000411 xsd:string

[Term]
id: DUO:0000024
name: Publication Moratorium
def: "This should be coupled with a date specified as ISO8601" []
xref: DUO:0000024
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000024
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000415 xsd:string

[Term]
id: DUO:0000025
name: Time Limit on Use
def: "This should be coupled with an integer value indicating the number of months." []
xref: DUO:0000025
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000025
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000418 xsd:string

[Term]
id: DUO:0000026
name: User Specific Restriction
def: "This requirement indicates that use is limited to use by approved users." []
xref: DUO:0000026
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000026
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000419 xsd:string

[Term]
id: DUO:0000027
name: Project Specific Restriction
def: "This requirement indicates that use is limited to use within an approved project." []
xref: DUO:0000027
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000027
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000414 xsd:string

[Term]
id: DUO:0000028
name: Institution Specific Restriction
def: "This requirement indicates that use is limited to use within an approved institution." []
xref: DUO:0000028
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000028
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000412 xsd:string

[Term]
id: DUO:0000029
name: Return to Database or Resource
def: "This requirement indicates that the requestor must return derived/enriched data to the database/resource." []
xref: DUO:0000029
is_a: SCDO:1000408 ! Data Use Requirements
property_value: SCDO:0000340 DUO:0000029
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000417 xsd:string

[Term]
id: ENVO:02500036
name: Pollution
def: "An environmental system process that results in the introduction of contaminants into an environment." []
synonym: "Environmental Pollution" EXACT []
xref: ENVO:02500036
is_a: SCDO:0000897 ! Physical Environment
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ENVO_02500036 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000912 xsd:string

[Term]
id: EUPATH:0000034
name: Alpha Thalassemia Genotype
def: "A genotype information which is about the presence and degree of alpha-thalassemia, a form of thalassemia involving the number of functional HBA1 and HBA2 genes." []
xref: EUPATH:0000034
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 NCIT:C95504 ! causes condition Hemoglobin H Disease
relationship: RO:0003303 NCIT:C95535 ! causes condition Alpha Thalassemia Trait
relationship: RO:0003303 SCDO:0000042 ! causes condition Alpha Thalassemia
relationship: SCDO:1000222 SCDO:1000240 ! causes molecular phenotype Reduced or Absent Hemoglobin A
property_value: SCDO:0000340 EUPATH:0000034
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000216 xsd:string

[Term]
id: EUPATH:0000050
name: Routine Clinical Visit
def: "A clinical visit that is primarily for a regular examination." []
xref: EUPATH:0000050
is_a: NCIT:C103165 ! Subject Visit Type
property_value: SCDO:0000340 EUPATH:0000050
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000848 xsd:string

[Term]
id: EUPATH:0000215
name: Severe Anemia
def: "An anemia with hemoglobin levels less than 5 gm/dL." []
xref: EUPATH:0000215
is_a: HP:0001903 ! Anemia
relationship: SCDO:0000664 NCIT:C15238 ! treated with Gene Therapy
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:0000664 SCDO:0000771 ! treated with Morphine
relationship: SCDO:0000664 SCDO:0001329 ! treated with Folic Acid
relationship: SCDO:0000664 SCDO:0008888 ! treated with Iron Chelation Therapy
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/EUPATH_0000215 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000055 xsd:string

[Term]
id: EUPATH:0000310
name: Information on Observation Details
def: "An information content entity that is about a clinical visit." []
xref: EUPATH:0000310
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000340 EUPATH:0000310
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000851 xsd:string

[Term]
id: EUPATH:0021227
name: Blood Urea Concentration
def: "A scalar measurement datum of the concentration of urea in blood that is a specified output of a blood test." []
synonym: "Serum Urea Concentration" EXACT []
xref: EUPATH:0021227
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1000190 SCDO:1000605 ! obtained via diagnostic tool Blood Urea Analysis
property_value: SCDO:0000340 EUPATH:0021227
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000603 xsd:string

[Term]
id: ExO:0000034
name: Occupation
def: "An individual attribute that is the usual or principal work or business of an individual." []
synonym: "Career" EXACT []
synonym: "Employment" EXACT []
synonym: "Job" EXACT []
synonym: "Vocation" EXACT []
xref: ExO:0000034
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:0001090 ! Socioeconomic Factors
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ExO_0000034 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000821 xsd:string

[Term]
id: ExO:0000048
name: Built Environment
def: "Human-made surroundings that provide the setting for human activity, ranging in scale from personal shelter and buildings to neighborhoods and cite, and can often include their supporting infrastructure, such as water supply or energy networks." []
xref: ExO:0000048
is_a: SCDO:0000897 ! Physical Environment
property_value: SCDO:0000340 ExO:0000048
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000167 xsd:string

[Term]
id: GAZ:00000448
name: Geographic Location
def: "A reference to a place on the Earth, by its name or by its geographical location." []
synonym: "Geographic Region" EXACT []
xref: GAZ:00000448
is_a: SCDO:0000897 ! Physical Environment
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/GAZ_00000448 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000451 xsd:string

[Term]
id: GSSO:000109
name: Intersex
def: "Intersex is an umbrella term with a complex history. It is usually used to refer to persons with congenital conditions which involve differences in the many intertwined processes of sexual development." []
xref: GSSO:000109
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 GSSO:000109
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000672 xsd:string

[Term]
id: GSSO:003239
name: Ethical Principle
def: "Principles which provide a framework within which ethical dilemmas and other problems may be analyzed." []
xref: GSSO:003239
is_a: SCDO:1000430 ! Ethics Related Concept
property_value: SCDO:0000340 GSSO:003239
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000427 xsd:string

[Term]
id: HP:0000005
name: Mode of Inheritance
def: "The pattern in which a particular genetic trait or disorder is passed from one generation to the next." []
synonym: "Inheritance" EXACT []
xref: HP:0000005
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000005 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001367 xsd:string

[Term]
id: HP:0000006
name: Autosomal Dominant
def: "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." []
synonym: "Autosomal Dominant Form" EXACT []
synonym: "Autosomal Dominant Inheritance" EXACT []
synonym: "Autosomal Dominant Predisposition" EXACT []
xref: HP:0000006
is_a: HP:0000005 ! Mode of Inheritance
property_value: SCDO:0000340 HP:0000006
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000140 xsd:string

[Term]
id: HP:0000007
name: Autosomal Recessive
def: "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygous (two copies of the same mutant allele) or compound heterozygous (whereby each copy of a gene has a distinct mutant allele)." []
synonym: "Autosomal Recessive Form" EXACT []
synonym: "Autosomal Recessive Inheritance" EXACT []
synonym: "Autosomal Recessive Predisposition" EXACT []
xref: HP:0000007
is_a: HP:0000005 ! Mode of Inheritance
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000007 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001368 xsd:string

[Term]
id: HP:0000027
name: Azoospermia
def: "Absence of any measurable level of sperm in a male's semen." []
synonym: "Absent Sperm in Semen" EXACT []
xref: HP:0000027
is_a: HP:0000080 ! Abnormality of Reproductive System Physiology
property_value: SCDO:0000340 HP:0000027
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000092 xsd:string

[Term]
id: HP:0000044
name: Hypogonadotropic Hypogonadism
def: "Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH)." []
synonym: "Hypogonadotropic Hypogonadism" EXACT []
synonym: "Secondary Hypogonadism" EXACT []
xref: HP:0000044
is_a: HP:0000080 ! Abnormality of Reproductive System Physiology
property_value: SCDO:0000340 HP:0000044
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002903 xsd:string

[Term]
id: HP:0000077
name: Abnormality of the Kidney
def: "An abnormality of the kidney." []
synonym: "Abnormal Kidney" EXACT []
synonym: "Anomaly of the Kidney" EXACT []
synonym: "Renal Anomaly" EXACT []
xref: HP:0000077
is_a: HP:0000079 ! Abnormality of the Urinary System
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000077 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002133 xsd:string

[Term]
id: HP:0000078
name: Abnormality of the Genital System
def: "An abnormality of the genital system." []
synonym: "Genital Abnormalities" EXACT []
synonym: "Genital Abnormality" EXACT []
synonym: "Genital Anomalies" EXACT []
synonym: "Genital Defects" EXACT []
xref: HP:0000078
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0000078
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000263 xsd:string

[Term]
id: HP:0000079
name: Abnormality of the Urinary System
def: "An abnormality of the urinary system." []
synonym: "Anomaly of the Urinary System" EXACT []
synonym: "Urinary Tract Abnormalities" EXACT []
synonym: "Urinary Tract Abnormality" EXACT []
synonym: "Urinary Tract Anomalies" EXACT []
synonym: "Urinary Tract Anomaly" EXACT []
xref: HP:0000079
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0000079
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001347 xsd:string

[Term]
id: HP:0000080
name: Abnormality of Reproductive System Physiology
def: "An abnormal functionality of the genital system." []
synonym: "Abnormality of Genital Physiology" EXACT []
xref: HP:0000080
is_a: HP:0000078 ! Abnormality of the Genital System
property_value: SCDO:0000340 HP:0000080
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000270 xsd:string

[Term]
id: HP:0000084
name: Kidney Failure
def: "Failure of the kidneys to adequately filter toxins and waste products from the blood; classified as acute (as in acute kidney injury) or chronic (as in chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur." []
comment: Treatment is dependent upon etiology and acuity. If refractory to medical therapy, renal replacement or dialysis may be indicated.
synonym: "Renal Failure" EXACT []
synonym: "Renal Insufficiency" EXACT []
xref: HP:0000084
is_a: HP:0000077 ! Abnormality of the Kidney
is_a: SCDO:1000383 ! Renal Complication
relationship: SCDO:0000663 NCIT:C17241 ! diagnosed using tool Urine Test
relationship: SCDO:0000664 SCDO:1000004 ! treated with Renal Replacement Therapy
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000220 CMO:0000057 ! diagnosed using measurement Serum Creatinine Level
relationship: SCDO:1000220 SCDO:0001210 ! diagnosed using measurement Urine Albumin Excretion Rate
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MP_0003606 xsd:string
property_value: SCDO:0000468 "Variable" xsd:string
property_value: SCDO:0000472 "May be Acute (acute kidney injury) or chronic (chronic kidney disease)." xsd:string
property_value: SCDO:0000661 "Has a variety of causes - dependent upon acuity - see definitions for acute kidney injury (acute renal failure) and chronic kidney disease." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000674 xsd:string

[Term]
id: HP:0000096
name: Glomerulosclerosis
def: "Scarring and fibrosis within the glomerulus." []
synonym: "Glomerular Sclerosis" EXACT []
synonym: "Renal Glomerular Fibrosis" EXACT []
xref: HP:0000096
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source "NHLBI 2014 Guidelines" xsd:string
property_value: SCDO:0000340 HP:0000096
property_value: SCDO:0000661 "Any form of injury to the kidney can lead to glomerulosclerosis." xsd:string
property_value: SCDO:0000662 "Histologically noted by scarring and fibrosis in the glomerulus." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000460 xsd:string

[Term]
id: HP:0000097
name: Focal Segmental Glomerulosclerosis
def: "Segmental accumulation of scar tissue in individual (but not all) glomeruli." []
synonym: "Focal and Segmental Glomerular Sclerosis" EXACT []
synonym: "Focal and Segmental Glomerulosclerosis" EXACT []
synonym: "Focal Glomerulosclerosis" EXACT []
xref: HP:0000097
is_a: HP:0000096 ! Glomerulosclerosis
property_value: SCDO:0000340 HP:0000097
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009968 xsd:string

[Term]
id: HP:0000099
name: Glomerulonephritis
def: "Inflammation of the renal glomeruli." []
synonym: "Glomerular Nephritis" EXACT []
synonym: "GN" EXACT []
xref: HP:0000099
is_a: HP:0000123 ! Nephritis
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000219 SCDO:0000508 ! diagnosed by Hematuria
relationship: SCDO:1000219 SCDO:0000932 ! diagnosed by Proteinuria
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0000099
property_value: SCDO:0000468 "May occur at any age." xsd:string
property_value: SCDO:0000661 "Variety of causes - in sickle cell disease, most common lesion is focal segmental glomerulosclerosis (FSGS) but also reported Membranoproliferative glomerulonephritis and other forms of glomerulonephritis." xsd:string
property_value: SCDO:0000662 "Patients with hematuria may have dark-colored urine.  Glomerulonephritis may lead to the proteinuria and \"foamy\" appearance of the urine.  If the latter is substantial, patients may develop clinically evident edema." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000458 xsd:string

[Term]
id: HP:0000112
name: Nephropathy
def: "A nonspecific term referring to disease or damage of the kidneys." []
synonym: "Kidney Damage" EXACT []
synonym: "Kidney Disease" EXACT []
xref: HP:0000112
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:0000663 NCIT:C17241 ! diagnosed using tool Urine Test
relationship: SCDO:0000663 SCDO:0001205 ! diagnosed using tool Urinary Albumin Test
relationship: SCDO:0000663 SCDO:0001206 ! diagnosed using tool Urinary Creatinine Test
relationship: SCDO:0000664 SCDO:0000055 ! treated with Angiotensin-Converting Enzyme Inhibitors
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:1000220 CMO:0000057 ! diagnosed using measurement Serum Creatinine Level
relationship: SCDO:1000220 SCDO:0001209 ! diagnosed using measurement Urine Albumin Concentration
relationship: SCDO:1000220 SCDO:0001213 ! diagnosed using measurement Urine Creatinine Concentration
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 HP:0000112
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000795 xsd:string

[Term]
id: HP:0000118
name: Abnormal Phenotype
def: "A phenotype that shows detectable differences from normal." []
synonym: "Phenotypic Abnormality" EXACT []
xref: HP:0000118
is_a: OGMS:0000023 ! Phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/FYPO_0001985 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009818 xsd:string

[Term]
id: HP:0000123
name: Nephritis
def: "The presence of inflammation affecting the kidney." []
synonym: "Kidney Inflammation" EXACT []
xref: HP:0000123
is_a: HP:0000077 ! Abnormality of the Kidney
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: SCDO:1000383 ! Renal Complication
relationship: SCDO:0000663 NCIT:C17241 ! diagnosed using tool Urine Test
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0000123
property_value: SCDO:0000661 "May be caused by autoimmune disease, allergic responses, toxic injury, infectious causes." xsd:string
property_value: SCDO:0000662 "May be associated with loss of kidney function, pyuria or hematuria, and proteinuria dependent upon cause." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000793 xsd:string

[Term]
id: HP:0000132
name: Menorrhagia
def: "Prolonged and/or excessive menses at regular intervals in excess of 80 ml or lasting longer than 7 days." []
synonym: "Abnormally Heavy Bleeding During Menstruation" EXACT []
synonym: "Hypermenorrhea" EXACT []
xref: HP:0000132
is_a: HP:0012243 ! Abnormal Reproductive System Morphology
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000132 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000745 xsd:string

[Term]
id: HP:0000225
name: Gingival Bleeding
def: "Hemorrhage affecting the gingiva." []
synonym: "Bleeding Gums" EXACT []
synonym: "Gingival Hemorrhage" EXACT []
synonym: "Gingivorrhagia" EXACT []
xref: HP:0000225
is_a: HP:0000271 ! Abnormality of the Face
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000225 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000452 xsd:string

[Term]
id: HP:0000271
name: Abnormality of the Face
def: "An abnormality of the face." []
synonym: "Facial Abnormality" EXACT []
xref: HP:0000271
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000271 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003024 xsd:string

[Term]
id: HP:0000388
name: Otitis Media
def: "Inflammation or infection of the middle ear." []
comment: is caused by: Usually bacterial but can be caused by fungus or virus infection.\n\nis characterised by: Pain or discharge from one or both ears
xref: HP:0000388
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: IDO:0000586 ! Infection
relationship: SCDO:0000664 IDO:0000560 ! treated with Antifungal
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000303 "Source needed for additional information." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000388 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000846 xsd:string

[Term]
id: HP:0000478
name: Abnormality of the Eye
def: "Any abnormality of the eye, including location, spacing, and intraocular abnormalities." []
xref: HP:0000478
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0000478
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000294 xsd:string

[Term]
id: HP:0000505
name: Visual Impairment
def: "Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery." []
synonym: "Impaired Vision" EXACT []
synonym: "Impaired Visual Function" EXACT []
synonym: "Loss of Eyesight" EXACT []
synonym: "Poor Vision" EXACT []
xref: HP:0000505
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
property_value: SCDO:0000340 HP:0000505
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000022 xsd:string

[Term]
id: HP:0000618
name: Blindness
def: "Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degress in radius around central fixation." []
synonym: "Total Vision Loss" EXACT []
xref: HP:0000618
is_a: HP:0000505 ! Visual Impairment
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 HP:0000618
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000021 xsd:string

[Term]
id: HP:0000707
name: Abnormality of the Nervous System
def: "Any abnormality of the nervous system." []
synonym: "Brain and/or Spinal Cord Issue" EXACT []
synonym: "Neurologic Abnormalities" EXACT []
synonym: "Neurological Abnormality" EXACT []
xref: HP:0000707
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000707 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009698 xsd:string

[Term]
id: HP:0000708
name: Behavioural Abnormality
def: "An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities." []
synonym: "Behavioral Abnormality" EXACT []
synonym: "Behavioural Abnormality" EXACT []
synonym: "Behavioural Changes" EXACT []
synonym: "Behavioural Disorders" EXACT []
synonym: "Behavioural Disturbances" EXACT []
synonym: "Behavioural Problems" EXACT []
synonym: "Behavioural Symptoms" EXACT []
synonym: "Behavioural/Psychiatric Abnormalities" EXACT []
synonym: "Behavioural/Psychiatric Abnormality" EXACT []
synonym: "Psychiatric Disorders" EXACT []
synonym: "Psychiatric Disturbances" EXACT []
xref: HP:0000708
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000303 "Include \"Poor School Performance\" as a sub-class." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000708 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000105 xsd:string

[Term]
id: HP:0000726
name: Dementia
def: "A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior." []
synonym: "Dementia, Progressive" EXACT []
synonym: "Progressive Dementia" EXACT []
xref: HP:0000726
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
property_value: SCDO:0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0000726
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000345 xsd:string

[Term]
id: HP:0000763
name: Sensory Neuropathy
def: "Peripheral neuropathy affecting the sensory nerves." []
synonym: "Peripheral Sensory Neuropathy" EXACT []
xref: HP:0000763
is_a: HP:0009830 ! Peripheral Neuropathy
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000763 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001038 xsd:string

[Term]
id: HP:0000789
name: Infertility
def: "Inability to produce live offspring." []
synonym: "Sterility" EXACT []
xref: HP:0000789
is_a: HP:0000080 ! Abnormality of Reproductive System Physiology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 MP:0001924
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000639 xsd:string

[Term]
id: HP:0000798
name: Oligospermia
def: "Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen." []
synonym: "Low Sperm Count" EXACT []
xref: HP:0000798
is_a: HP:0000080 ! Abnormality of Reproductive System Physiology
property_value: SCDO:0000340 HP:0000798
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000827 xsd:string

[Term]
id: HP:0000805
name: Enuresis
def: "Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible." []
xref: HP:0000805
is_a: HP:0000079 ! Abnormality of the Urinary System
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000805 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000434 xsd:string

[Term]
id: HP:0000815
name: Hypergonadotropic Hypogonadism
def: "Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay." []
synonym: "Hypergonadotrophic Hypogonadism" EXACT []
synonym: "Primary Hypogonadism" EXACT []
xref: HP:0000815
is_a: HP:0000080 ! Abnormality of Reproductive System Physiology
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000815 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000586 xsd:string

[Term]
id: HP:0000818
name: Abnormality of the Endocrine System
def: "An abnormality of the endocrine system." []
xref: HP:0000818
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0000818
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002780 xsd:string

[Term]
id: HP:0000819
name: Diabetes Mellitus
def: "A group of abnormalities characterized by hyperglycemia and glucose intolerance." []
xref: HP:0000819
is_a: HP:0000818 ! Abnormality of the Endocrine System
is_a: HP:0011014 ! Abnormal Glucose Homeostasis
is_a: SCDO:0000267 ! Comorbid Disease
relationship: SCDO:0000664 NCIT:C15900 ! treated with Lifestyle Therapy
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000819 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000367 xsd:string

[Term]
id: HP:0000820
name: Abnormality of the Thyroid Gland
def: "An abnormality of the thyroid gland." []
synonym: "Thyroid Abnormality" EXACT []
xref: HP:0000820
is_a: HP:0000818 ! Abnormality of the Endocrine System
property_value: SCDO:0000340 HP:0000820
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000278 xsd:string

[Term]
id: HP:0000821
name: Hypothyroidism
def: "Deficiency of thyroid hormone." []
synonym: "Low T4" EXACT []
synonym: "Underactive Thyroid" EXACT []
xref: HP:0000821
is_a: HP:0000820 ! Abnormality of the Thyroid Gland
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000821 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000603 xsd:string

[Term]
id: HP:0000822
name: Hypertension
def: "The presence of chronic increased pressure in the systemic arterial system." []
xref: HP:0000822
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
property_value: SCDO:0000340 HP:0000822
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008801 xsd:string

[Term]
id: HP:0000823
name: Delayed Puberty
def: "Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty." []
synonym: "Delayed Development of Secondary Sex Characteristics" EXACT []
synonym: "Delayed Onset of Sexual Maturity" EXACT []
synonym: "Delayed Pubertal Development" EXACT []
synonym: "Delayed pubertal growth" EXACT []
synonym: "Delayed Sexual Maturation" EXACT []
synonym: "Delayed Sexual Maturity" EXACT []
synonym: "Pubertal Delay" EXACT []
xref: HP:0000823
is_a: HP:0000818 ! Abnormality of the Endocrine System
is_a: HP:0001507 ! Growth Abnormality
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 HP:0000823
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000342 xsd:string

[Term]
id: HP:0000824
name: Growth Hormone Deficiency
def: "Insufficient production of growth hormone, which is produced by the anterior pituitary gland. Growth hormone is a major participant in control of growth and metabolism." []
xref: HP:0000824
is_a: HP:0000818 ! Abnormality of the Endocrine System
property_value: SCDO:0000340 HP:0000824
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008218 xsd:string

[Term]
id: HP:0000828
name: Abnormality of the Parathyroid Gland
def: "An abnormality of the parathyroid gland." []
xref: HP:0000828
is_a: HP:0000818 ! Abnormality of the Endocrine System
property_value: SCDO:0000340 HP:0000828
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000279 xsd:string

[Term]
id: HP:0000829
name: Hypoparathyroidism
def: "A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia." []
synonym: "Decreased Parathyroid Hormone Secretion" EXACT []
synonym: "Low Parathyroid Hormone" EXACT []
xref: HP:0000829
is_a: HP:0000828 ! Abnormality of the Parathyroid Gland
property_value: SCDO:0000340 HP:0000829
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007386 xsd:string

[Term]
id: HP:0000834
name: Abnormality of the Adrenal Glands
def: "Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kidneys." []
synonym: "Adrenal Abnormalities" EXACT []
synonym: "Adrenal Abnormality" EXACT []
xref: HP:0000834
is_a: HP:0000818 ! Abnormality of the Endocrine System
property_value: SCDO:0000340 HP:0000834
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007437 xsd:string

[Term]
id: HP:0000836
name: Hyperthyroidism
def: "An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3)." []
synonym: "Overactive Thyroid" EXACT []
xref: HP:0000836
is_a: HP:0000820 ! Abnormality of the Thyroid Gland
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000836 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000595 xsd:string

[Term]
id: HP:0000842
name: Hyperinsulinemia
def: "An increased concentration of insulin in the blood." []
synonym: "Elevated Insulin Level" EXACT []
xref: HP:0000842
is_a: HP:0000818 ! Abnormality of the Endocrine System
is_a: HP:0011014 ! Abnormal Glucose Homeostasis
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000842 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000587 xsd:string

[Term]
id: HP:0000843
name: Hyperparathyroidism
def: "Excessive production of parathyroid hormone (PTH) by the parathyroid glands." []
synonym: "Elevated Blood Parathyroid Hormone Level" EXACT []
xref: HP:0000843
is_a: HP:0000828 ! Abnormality of the Parathyroid Gland
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000843 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000592 xsd:string

[Term]
id: HP:0000855
name: Insulin Resistance
def: "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." []
synonym: "Body Fails to Respond to Insulin" EXACT []
xref: HP:0000855
is_a: HP:0011014 ! Abnormal Glucose Homeostasis
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:0000664 SCDO:0000498 ! treated with Healthy Lifestyle
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000855 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000644 xsd:string

[Term]
id: HP:0000873
name: Diabetes Insipidus
def: "A state of excessive water excretion and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus)." []
xref: HP:0000873
is_a: HP:0000818 ! Abnormality of the Endocrine System
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000873 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000366 xsd:string

[Term]
id: HP:0000876
name: Oligomenorrhea
def: "Infrequent menses (less than 6 per year or more than 35 days between cycles)." []
synonym: "Light or Infrequent Menstrual Periods" EXACT []
xref: HP:0000876
is_a: HP:0012243 ! Abnormal Reproductive System Morphology
property_value: SCDO:0000340 HP:0000876
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003158 xsd:string

[Term]
id: HP:0000924
name: Abnormality of the Skeletal System
def: "An abnormality of the skeletal system." []
synonym: "Skeletal Abnormalities" EXACT []
synonym: "Skeletal Anomalies" EXACT []
xref: HP:0000924
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0000924
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006301 xsd:string

[Term]
id: HP:0000938
name: Osteopenia
def: "Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5." []
synonym: "Decreased Bone Mineral Density" EXACT []
synonym: "Generalized Osteopenia" EXACT []
xref: HP:0000938
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:0000664 SCDO:0000382 ! treated with Diet, Food, and Nutrition
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:0000664 SCDO:0000498 ! treated with Healthy Lifestyle
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000938 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000843 xsd:string

[Term]
id: HP:0000939
name: Osteoporosis
def: "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD)." []
xref: HP:0000939
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000939 xsd:string
property_value: SCDO:0000661 "Genetic predisposition, low calcium diet, getting little exercise, smoking, decrease in estrogen at the menopause, steroid medicine use for a long time, Vitamin D insufficiency." xsd:string
property_value: SCDO:0000662 "Bone pain, backache, gradual loss of height, stooped posture, fractures." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000844 xsd:string

[Term]
id: HP:0000951
name: Abnormality of the Skin
def: "An abnormality of the skin." []
synonym: "Abnormal skin morphology" EXACT []
synonym: "Abnormal skin structure" EXACT []
synonym: "Dermatopathy" EXACT []
synonym: "Dermopathy" EXACT []
synonym: "Skin Abnormality" EXACT []
xref: HP:0000951
is_a: HP:0001574 ! Abnormality of the Integument
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000951 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008348 xsd:string

[Term]
id: HP:0000952
name: Jaundice
def: "Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." []
synonym: "Icterus" EXACT []
synonym: "Yellow Skin" EXACT []
synonym: "Yellowing of the Skin" EXACT []
xref: HP:0000952
is_a: HP:0011121 ! Abnormality of Skin Morphology
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000952 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000671 xsd:string

[Term]
id: HP:0000953
name: Cutaneous Hyperpigmentation
def: "A darkening of the skin related to an increase in melanin production and deposition." []
synonym: "Hyperpigmentation of the Skin" EXACT []
synonym: "Increased Skin Pigmentation" EXACT []
synonym: "Melanoderma" EXACT []
synonym: "Melanodermia" EXACT []
synonym: "Skin Hyperpigmentation" EXACT []
xref: HP:0000953
is_a: HP:0011121 ! Abnormality of Skin Morphology
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000953 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000308 xsd:string

[Term]
id: HP:0000961
name: Cyanosis
def: "Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood." []
synonym: "Blue Discoloration of the Skin" EXACT []
synonym: "Cyanotic" EXACT []
xref: HP:0000961
is_a: HP:0011121 ! Abnormality of Skin Morphology
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 HP:0000961
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000309 xsd:string

[Term]
id: HP:0000962
name: Hyperkeratosis
def: "Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum." []
xref: HP:0000962
is_a: HP:0011121 ! Abnormality of Skin Morphology
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000340 HP:0000962
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000589 xsd:string

[Term]
id: HP:0000967
name: Petechiae
def: "Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae." []
xref: HP:0000967
is_a: HP:0002597 ! Abnormality of the Vasculature
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 HP:0000967
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000892 xsd:string

[Term]
id: HP:0000969
name: Edema
def: "An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body." []
synonym: "Dropsy" EXACT []
synonym: "Fluid Retention" EXACT []
synonym: "Hydrops" EXACT []
synonym: "Oedema" EXACT []
synonym: "Water Retention" EXACT []
xref: HP:0000969
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000969 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000823 xsd:string

[Term]
id: HP:0000980
name: Pallor
def: "Abnormally pale skin." []
xref: HP:0000980
is_a: HP:0011121 ! Abnormality of Skin Morphology
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 HP:0000980
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000863 xsd:string

[Term]
id: HP:0000999
name: Pyoderma
def: "Any manifestation of a skin disease associated with the production of pus." []
synonym: "Pus-Filled Lesion" EXACT []
xref: HP:0000999
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: HP:0011122 ! Abnormality of Skin Physiology
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
property_value: SCDO:0000340 HP:0000999
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000946 xsd:string

[Term]
id: HP:0001010
name: Hypopigmentation
def: "A reduction of skin color related to a decrease in melanin production and deposition." []
synonym: "Hypopigmentation of the Skin" EXACT []
synonym: "Hypopigmented Skin" EXACT []
synonym: "Skin Hypopigmentation" EXACT []
xref: HP:0001010
is_a: HP:0011121 ! Abnormality of Skin Morphology
property_value: SCDO:0000340 HP:0001010
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000601 xsd:string

[Term]
id: HP:0001022
name: Albinism
def: "An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina)." []
synonym: "Achromasia" EXACT []
xref: HP:0001022
is_a: HP:0001010 ! Hypopigmentation
property_value: SCDO:0000340 HP:0001022
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000036 xsd:string

[Term]
id: HP:0001025
name: Urticaria
def: "Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure." []
synonym: "Hives" EXACT []
xref: HP:0001025
is_a: HP:0002597 ! Abnormality of the Vasculature
property_value: SCDO:0000340 HP:0001025
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001219 xsd:string

[Term]
id: HP:0001061
name: Acne
def: "A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts)." []
synonym: "Break Out" EXACT []
synonym: "Breaking Out" EXACT []
xref: HP:0001061
is_a: HP:0011123 ! Skin Inflammation
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 HP:0001061
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000012 xsd:string

[Term]
id: HP:0001081
name: Cholelithiasis
def: "Hard, pebble-like deposits that form within the gallbladder." []
synonym: "Gallstones" EXACT []
xref: HP:0001081
is_a: HP:0025031 ! Abnormality of the Digestive System
relationship: SCDO:0000664 ARO:0000064 ! treated with Amoxycillin
relationship: SCDO:0000664 CHEBI:6909 ! treated with Metronidazole
relationship: SCDO:0000664 NCIT:C519 ! treated with Gentamicin
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Add here \"bilirubin gallstones\" (see paper \"Liver involvement in sickle cell disease\" by Emel GÜRKAN et al.). in HP these are called \"Pigment Gallstones\"." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001081 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007091 xsd:string

[Term]
id: HP:0001197
name: Abnormality of Prenatal Development or Birth
def: "An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities." []
xref: HP:0001197
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0001197
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000262 xsd:string

[Term]
id: HP:0001250
name: Seizure
def: "Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures." []
synonym: "Seizures" EXACT []
xref: HP:0001250
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001250 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001030 xsd:string

[Term]
id: HP:0001254
name: Lethargy
def: "A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating." []
xref: HP:0001254
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000340 HP:0001254
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003089 xsd:string

[Term]
id: HP:0001260
name: Dysarthria
def: "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." []
synonym: "Difficulty Articulating Speech" EXACT []
synonym: "Dysarthric Speech" EXACT []
xref: HP:0001260
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "- Use description to add sub-classes of types of Dysarthria? -- Use text in comments to add relevant terms regarding disease progression? And link to these terms with relevant object property" xsd:string
property_value: SCDO:0000340 HP:0001260
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000403 xsd:string

[Term]
id: HP:0001265
name: Hyporeflexia
def: "Reduction of neurologic reflexes such as the knee-jerk reaction." []
synonym: "Decreased Reflex Response" EXACT []
synonym: "Decreased Reflexes" EXACT []
xref: HP:0001265
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000340 HP:0001265
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000602 xsd:string

[Term]
id: HP:0001269
name: Hemiparesis
def: "Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength." []
synonym: "Weakness of One Side of Body" EXACT []
xref: HP:0001269
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001269 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008272 xsd:string

[Term]
id: HP:0001271
name: Polyneuropathy
def: "A generalized disorder of peripheral nerves." []
synonym: "Peripheral Nerve Disease" EXACT []
xref: HP:0001271
is_a: HP:0009830 ! Peripheral Neuropathy
relationship: SCDO:0000663 NCIT:C17241 ! diagnosed using tool Urine Test
relationship: SCDO:0000663 NCIT:C85397 ! diagnosed using tool Spirometry
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 SCDO:0000822 ! treated with Occupational Therapy
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: http://purl.org/dc/elements/1.1/source http://www.msdmanuals.com/home/brain,-spinal-cord,-and-nerve-disorders/peripheral-nerve-disorders/polyneuropathy
property_value: http://purl.org/dc/elements/1.1/source http://www.uptodate.com/contents/overview-of-polyneuropathy
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001271 xsd:string
property_value: SCDO:0000661 "Acute polyneuropathy has many causes: Infections involving a toxin produced by bacteria, as occurs in diphtheria,An autoimmune reaction (when the body attacks its own tissues), as occurs in Guillain-Barré syndrome (see Guillain-Barré Syndrome), Drugs, including the anticonvulsant phenytoin, some antibiotics (such as chloramphenicol, nitrofurantoin, and sulfonamides), some chemotherapy drugs (such as vinblastine and vincristine), and some sedatives (such as barbital and hexobarbital), Cancer (such as multiple myeloma), which damages nerves by directly invading or putting pressure on them or by triggering an autoimmune reaction, Certain toxins, such as organophosphate insecticides, triorthocresyl phosphate (TOCP), and thallium\nThe cause of chronic polyneuropathy is often unknown. Known causes include the following: Diabetes Mellitus, Excessive use of alcohol, Nutritional deficiencies (such as thiamin deficiency), an uncommon cause in the United States, except among alcoholics who are malnourished, Vitamin B12 deficiency, which causes subacute combined degeneration of the spinal cord (see Subacute Combined Degeneration) and often pernicious anemia (see Inadequate absorption), An underactive thyroid gland (hypothyroidism), Toxic substances, including heavy metals such as lead and mercury, Kidney failure, Certain cancers, such as lung cancer, Rarely, vitamin B6 (pyridoxine) taken in excessive amounts." xsd:string
property_value: SCDO:0000662 "Acute polyneuropathy (as occurs in Guillain-Barré syndrome) begins suddenly in both legs and progresses rapidly upward to the arms. Symptoms include weakness and a pins-and-needles sensation or loss of sensation. The muscles that control breathing may be affected, resulting in respiratory failure.In the most common form of chronic polyneuropathy, only sensation is affected. Usually, the feet are affected first, but sometimes the hands are. A pins-and-needles sensation, numbness, burning pain, and loss of vibration sense and position sense (knowing where the arms and legs are) are prominent symptoms. Because position sense is lost, walking and even standing become unsteady. Consequently, muscles may not be used. Eventually, they may weaken and waste away. Then, muscles may become stiff and permanently shortened (called contractures). Diabetic neuropathy commonly causes painful tingling or burning sensations in the hands and feet-a condition called distal polyneuropathy. Pain is often worse at night and may be aggravated by touch or by a change in temperature. People may lose the senses of temperature and pain, so they often burn themselves and may have open sores caused by prolonged pressure or other injuries. Without pain as a warning of too much stress, joints are susceptible to injuries. This type of injury is called neurogenic arthropathy (Charcot joints) Polyneuropathy often affects the nerves of the autonomic nervous system, which controls involuntary functions in the body (such as blood pressure, heart rate, digestion, salivation, and urination). Typical symptoms are constipation, sexual dysfunction, and fluctuating blood pressure-most notably a sudden fall in blood pressure when a person stands up (orthostatic hypotension). The skin may become pale and dry, and sweating may be reduced. Much less often, control of bowel movements or urination is lost, leading to fecal or urinary incontinence." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000914 xsd:string

[Term]
id: HP:0001279
name: Syncope
def: "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow." []
synonym: "Fainting Spell" EXACT []
xref: HP:0001279
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001279 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008553 xsd:string

[Term]
id: HP:0001287
name: Meningitis
def: "Inflammation of the meninges." []
xref: HP:0001287
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: IDO:0000586 ! Infection
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 HP:0001287
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000744 xsd:string

[Term]
id: HP:0001289
name: Confusion
def: "Lack of clarity and coherence of thought, perception, understanding, or action." []
xref: HP:0001289
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000303 "-- Perhaps move below \"Behavioral Abnormality\"?" xsd:string
property_value: SCDO:0000340 HP:0001289
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000273 xsd:string

[Term]
id: HP:0001298
name: Encephalopathy
def: "A term that means brain disease, damage, or malfunction. In general, it is manifested by an altered mental state." []
xref: HP:0001298
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000663 OBI:0000185 ! diagnosed using tool Imaging Assay
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0000420 ! diagnosed using tool Electroencephalography
relationship: SCDO:0000664 SCDO:0000382 ! treated with Diet, Food, and Nutrition
relationship: SCDO:0000664 SCDO:0000983 ! treated with Renal Dialysis
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000303 "-- Provide source for additional info. --  -- Specify which Blood Tests and Which Imaging Tests are used to diagnose." xsd:string
property_value: SCDO:0000340 HP:0001298
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000429 xsd:string

[Term]
id: HP:0001342
name: Cerebral Hemorrhage
def: "Hemorrhage into the parenchyma of the brain." []
synonym: "Bleeding in Brain" EXACT []
synonym: "Hemorrhagic Stroke" EXACT []
synonym: "Intracerebral Bleeding" EXACT []
synonym: "Intracerebral Hemorrhage" EXACT []
xref: HP:0001342
is_a: HP:0002170 ! Intracranial Hemorrhage
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 OBI:0000185 ! diagnosed using tool Imaging Assay
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0001327 ! diagnosed using tool Fluorescein Angiography
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000822 ! treated with Occupational Therapy
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001342 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000209 xsd:string

[Term]
id: HP:0001343
name: Kernicterus
def: "Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction." []
xref: HP:0001343
is_a: HP:0012639 ! Abnormal Nervous System Morphology
property_value: SCDO:0000340 HP:0001343
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000673 xsd:string

[Term]
id: HP:0001369
name: Arthritis
def: "Inflammation of a joint." []
synonym: "Joint Inflammation" EXACT []
xref: HP:0001369
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001369 xsd:string
property_value: SCDO:0000468 "Any age" xsd:string
property_value: SCDO:0000661 "Infection (bacteria), ischemia, joint injury (trauma, surgery), degeneration." xsd:string
property_value: SCDO:0000662 "Joint pain, joint swelling, stiffness, lack of function." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000075 xsd:string

[Term]
id: HP:0001370
name: Rheumatoid Arthritis
def: "An autoimmune response that primarily affects connective tissue; it also results in chronic inflammation of the joints, especially of the hands and feet and may also cause inflammation of the tissue around the joints, as well as other organs in the body." []
synonym: "Osteoarthrosis Deformans" EXACT []
synonym: "RA" EXACT []
xref: HP:0001370
is_a: HP:0001369 ! Arthritis
is_a: HP:0002715 ! Abnormality of the Immune System
relationship: SCDO:0000664 SCDO:0000822 ! treated with Occupational Therapy
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MP_0003561 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001011 xsd:string

[Term]
id: HP:0001371
name: Flexion Contracture
def: "A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints." []
synonym: "Flexion Contractures" EXACT []
synonym: "Flexion Contractures of Joints" EXACT []
synonym: "Joint Contracture" EXACT []
synonym: "Joint Contractures" EXACT []
xref: HP:0001371
is_a: HP:0000924 ! Abnormality of the Skeletal System
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001371 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001324 xsd:string

[Term]
id: HP:0001382
name: Joint Hypermobility
def: "The ability of a joint to move beyond its normal range of motion." []
synonym: "Double-Jointed" EXACT []
synonym: "Hyperextensible Joints" EXACT []
synonym: "Increased Mobility of Joints" EXACT []
synonym: "Joint Hyperextensibility" EXACT []
xref: HP:0001382
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001382 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000672 xsd:string

[Term]
id: HP:0001392
name: Abnormality of the Liver
def: "An abnormality of the liver." []
synonym: "Complication of the Liver" EXACT []
synonym: "Liver Abnormality" EXACT []
synonym: "Liver Complication" EXACT []
xref: HP:0001392
is_a: HP:0025031 ! Abnormality of the Digestive System
property_value: SCDO:0000340 HP:0001392
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000272 xsd:string

[Term]
id: HP:0001394
name: Cirrhosis
def: "A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function." []
synonym: "Hepatic Cirrhosis" EXACT []
synonym: "Scar Tissue Replaces Healthy Tissue in the Liver" EXACT []
xref: HP:0001394
is_a: HP:0001392 ! Abnormality of the Liver
property_value: SCDO:0000340 HP:0001394
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001488 xsd:string

[Term]
id: HP:0001395
name: Hepatic Fibrosis
def: "The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process." []
xref: HP:0001395
is_a: HP:0001392 ! Abnormality of the Liver
property_value: SCDO:0000340 HP:0001395
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001493 xsd:string

[Term]
id: HP:0001406
name: Intrahepatic Cholestasis
def: "Impairment of bile flow due to obstruction in the small bile ducts within the liver." []
xref: HP:0001406
is_a: HP:0001392 ! Abnormality of the Liver
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Is managed by: analgesia, hydration, antibiotics, and in severe cases exchange transfusion may be needed." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001406 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009774 xsd:string

[Term]
id: HP:0001433
name: Hepatosplenomegaly
def: "Simultaneous enlargement of the liver and spleen." []
xref: HP:0001433
is_a: HP:0001392 ! Abnormality of the Liver
is_a: HP:0001743 ! Abnormality of the Spleen
is_a: NCIT:C115224 ! Hepatic Complication
property_value: SCDO:0000340 HP:0001433
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007326 xsd:string

[Term]
id: HP:0001507
name: Growth Abnormality
def: "Abnormality of growth." []
synonym: "Abnormal Growth" EXACT []
synonym: "Growth Issue" EXACT []
xref: HP:0001507
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0001507
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000271 xsd:string

[Term]
id: HP:0001508
name: Failure to Thrive
def: "Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm." []
synonym: "Faltering Weight" EXACT []
synonym: "FTT" EXACT []
synonym: "Poor Weight Gain" EXACT []
synonym: "Postnatal Failure to Thrive" EXACT []
synonym: "Undergrowth" EXACT []
synonym: "Weight Faltering" EXACT []
xref: HP:0001508
is_a: HP:0001507 ! Growth Abnormality
property_value: SCDO:0000340 HP:0001508
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002729 xsd:string

[Term]
id: HP:0001511
name: Intrauterine Growth Restriction
def: "An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age." []
synonym: "Intrauterine Growth Retardation" EXACT []
synonym: "IUGR" EXACT []
synonym: "Prenatal Growth Retardation" EXACT []
synonym: "Prenatal-Onset Growth Retardation" EXACT []
synonym: "Small for Gestational Age Infant" EXACT []
xref: HP:0001511
is_a: HP:0001197 ! Abnormality of Prenatal Development or Birth
is_a: HP:0001507 ! Growth Abnormality
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001511 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000658 xsd:string

[Term]
id: HP:0001513
name: Obesity
def: "Body weight that is grossly above the acceptable or desirable weight, usually due to accumulation of excess fats in the body. The standards may vary with age, sex, genetic or cultural background. In the body mass index (BMI), a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese." []
synonym: "Having too much body fat" EXACT []
xref: HP:0001513
is_a: HP:0001507 ! Growth Abnormality
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:0000664 SCDO:0001284 ! treated with Behaviour Therapy
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001513 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000816 xsd:string

[Term]
id: HP:0001574
name: Abnormality of the Integument
def: "An abnormality of the integument, which consists of the skin and the superficial fascia." []
xref: HP:0001574
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0001574
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000274 xsd:string

[Term]
id: HP:0001622
name: Preterm Delivery
def: "The birth of a baby of less than 37 weeks of gestational age." []
synonym: "Premature Birth" EXACT []
synonym: "Premature Delivery" EXACT []
synonym: "Premature Delivery of Affected Infants" EXACT []
synonym: "Preterm Birth" EXACT []
xref: HP:0001622
is_a: HP:0001197 ! Abnormality of Prenatal Development or Birth
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001622 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000920 xsd:string

[Term]
id: HP:0001626
name: Abnormality of Cardiovascular System
def: "Any abnormality of the cardiovascular system." []
synonym: "Abnormality of the Cardiovascular System" EXACT []
synonym: "Cardiovascular Abnormality" EXACT []
xref: HP:0001626
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001626 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002245 xsd:string

[Term]
id: HP:0001635
name: Cardiac Failure
def: "The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction." []
synonym: "Cardiac Insufficiency," EXACT []
synonym: "CHF" EXACT []
synonym: "Congestive Heart Failure" EXACT []
synonym: "Heart Failure" EXACT []
xref: HP:0001635
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
property_value: SCDO:0000340 https://hpo.jax.org/app/browse/term/HP:0001635
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004877 xsd:string

[Term]
id: HP:0001640
name: Cardiomegaly
def: "Increased size of the heart." []
synonym: "Enlarged Heart" EXACT []
synonym: "Increased Heart Size" EXACT []
xref: HP:0001640
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001640 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008273 xsd:string

[Term]
id: HP:0001658
name: Myocardial Infarction
def: "Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin." []
xref: HP:0001658
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001658 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007991 xsd:string

[Term]
id: HP:0001701
name: Pericarditis
def: "Inflammation of the sac-like covering around the heart (pericardium)." []
xref: HP:0001701
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
property_value: SCDO:0000340 HP:0001701
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003765 xsd:string

[Term]
id: HP:0001712
name: Left Ventricular Hypertrophy
def: "Enlargement or increased size of the heart left ventricle." []
synonym: "Heart Left Ventricle Hypertrophy" EXACT []
synonym: "Left Ventricular Wall Hypertrophy" EXACT []
xref: HP:0001712
is_a: HP:0001714 ! Ventricular Hypertrophy
property_value: SCDO:0000340 HP:0001712
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002803 xsd:string

[Term]
id: HP:0001714
name: Ventricular Hypertrophy
def: "Enlargement of the cardiovascular ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy." []
xref: HP:0001714
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001714 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001231 xsd:string

[Term]
id: HP:0001743
name: Abnormality of the Spleen
def: "An abnormality of the spleen." []
xref: HP:0001743
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: HP:0025031 ! Abnormality of the Digestive System
property_value: SCDO:0000340 HP:0001743
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000370 xsd:string

[Term]
id: HP:0001744
name: Splenomegaly
def: "Abnormal increased size of the spleen." []
comment: Results from splenic sequestration
synonym: "Increased Spleen Size" EXACT []
xref: HP:0001744
is_a: HP:0001743 ! Abnormality of the Spleen
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001744 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005287 xsd:string

[Term]
id: HP:0001787
name: Abnormal Delivery
def: "An abnormality of the birth process." []
xref: HP:0001787
is_a: HP:0001197 ! Abnormality of Prenatal Development or Birth
property_value: SCDO:0000340 HP:0001787
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000372 xsd:string

[Term]
id: HP:0001789
name: Hydrops Fetalis
def: "The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema." []
xref: HP:0001789
is_a: HP:0000969 ! Edema
is_a: HP:0001197 ! Abnormality of Prenatal Development or Birth
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0001303 ! treated with Exchange Transfusion, Whole Blood
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001789 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000578 xsd:string

[Term]
id: HP:0001871
name: Abnormality of Blood and Blood-Forming Tissues
def: "An abnormality of the hematopoietic system." []
synonym: "Abnormality of the Hematopoietic System" EXACT []
synonym: "Hematological Abnormality" EXACT []
synonym: "Hematopoietic System Abnormality" EXACT []
xref: HP:0001871
is_a: HP:0000118 ! Abnormal Phenotype
is_a: SCDO:1000820 ! Hematopoietic System Phenotype
property_value: SCDO:0000340 HP:0001871
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000264 xsd:string

[Term]
id: HP:0001872
name: Abnormal Thrombocyte Morphology
def: "An abnormality of platelets. Platelets, also known as thrombocytes, are non-nucleated disk-shaped cells mainly involved in blood coagulation." []
synonym: "Platelet Abnormalities" EXACT []
xref: HP:0001872
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
property_value: SCDO:0000340 HP:0001872
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000616 xsd:string

[Term]
id: HP:0001873
name: Thrombocytopenia
def: "A reduction in the number of circulating thrombocytes." []
xref: HP:0001873
is_a: HP:0011873 ! Abnormal Platelet Count
property_value: SCDO:0000340 HP:0001873
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002700 xsd:string

[Term]
id: HP:0001874
name: Abnormality of Neutrophils
def: "A neutrophil abnormality." []
comment: Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defense during inflammation and infections. They are myeloid granulocytes and their names is derived from the fact that their cytoplasm contains granules that stain with acidic dye as well as granules that stain with basic dye. Their nuclei consist of three to five lobes connected by slender threads of chromatin. Mature neutrophils live for approximately one day.
xref: HP:0001874
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
property_value: SCDO:0000340 https://hpo.jax.org/app/browse/term/HP:0001874
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000440 xsd:string

[Term]
id: HP:0001875
name: Neutropenia
def: "An abnormally low number of neutrophils in the peripheral blood." []
synonym: "Decreased Neutrophil Count" EXACT []
synonym: "Low Blood Neutrophil Count" EXACT []
synonym: "Low Neutrophil Count" EXACT []
synonym: "Peripheral Neutropenia" EXACT []
xref: HP:0001875
is_a: HP:0011991 ! Abnormal Neutrophil Count
property_value: SCDO:0000340 HP:0001875
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009334 xsd:string

[Term]
id: HP:0001877
name: Abnormal Erythrocyte Morphology
def: "Any structural abnormality of erythrocytes (red-blood cells)." []
xref: HP:0001877
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
property_value: SCDO:0000340 HP:0001877
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000285 xsd:string

[Term]
id: HP:0001878
name: Hemolytic Anemia
def: "A type of anemia caused by premature destruction of red blood cells (hemolysis)." []
xref: HP:0001878
is_a: HP:0001903 ! Anemia
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001878 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003844 xsd:string

[Term]
id: HP:0001882
name: Leukopenia
def: "An abnormal decreased number of leukocytes in the blood." []
synonym: "Decreased Blood Leukocyte Number" EXACT []
synonym: "Low White Blood Cell Count" EXACT []
xref: HP:0001882
is_a: HP:0011893 ! Abnormal Leukocyte Count
property_value: SCDO:0000340 HP:0001882
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000614 xsd:string

[Term]
id: HP:0001889
name: Megaloblastic Anemia
def: "Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts)." []
xref: HP:0001889
is_a: HP:0001903 ! Anemia
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001889 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005864 xsd:string

[Term]
id: HP:0001894
name: Thrombocytosis
def: "Thrombocythemia and thrombocytosis are conditions with a higher than normal number of platelets. The term \"thrombocythemia\" is preferred when the cause of a high platelet count isn't known. The condition sometimes is called primary or essential thrombocythemia. Increased numbers of platelets in the peripheral blood." []
synonym: "Increased Number of Platelets in Blood" EXACT []
synonym: "Increased Platelet Count" EXACT []
xref: HP:0001894
is_a: HP:0011873 ! Abnormal Platelet Count
property_value: SCDO:0000340 HP:0001894
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000618 xsd:string

[Term]
id: HP:0001896
name: Reticulocytopenia
def: "A reduced number of reticulocytes in the peripheral blood." []
synonym: "Low Reticulocyte Count" EXACT []
synonym: "Reduced Number of Reticulocytes" EXACT []
synonym: "Reduced Reticulocyte Count" EXACT []
xref: HP:0001896
is_a: HP:0004312 ! Abnormality of Reticulocytes
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000340 HP:0001896
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001423 xsd:string

[Term]
id: HP:0001903
name: Anemia
def: "A reduction in erythrocytes volume or hemoglobin concentration." []
xref: HP:0001903
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001903 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005660 xsd:string

[Term]
id: HP:0001909
name: Leukaemia
def: "A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes." []
synonym: "Blood Cancer" EXACT []
xref: HP:0001909
is_a: OBI:1110053 ! Cancer
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001909 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000687 xsd:string

[Term]
id: HP:0001919
name: Acute Kidney Injury
def: "Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia)." []
comment: Acute renal failure is usually classified into prerenal (response to severe volume depletion), intrinsic (response to acute cytotoxic, ischemic, or inflammatory insults) and postrenal (response to obstruction of the passage of urine) etiologies.
synonym: "Acute Kidney Failure" EXACT []
synonym: "Acute Renal Failure" EXACT []
xref: HP:0001919
is_a: HP:0000084 ! Kidney Failure
relationship: SCDO:0000664 SCDO:0000983 ! treated with Renal Dialysis
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:1000220 CMO:0000057 ! diagnosed using measurement Serum Creatinine Level
relationship: SCDO:1000220 CMO:0000256 ! diagnosed using measurement Urine Measurement
relationship: SCDO:1000220 SCDO:0000457 ! diagnosed using measurement Glomerular Filtration Rate
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Further work" xsd:string
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000303 "There is conflicting positioning of this term in different ontologies. Need an expert to decide descriptions and positioning of this and related terms." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001919 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000017 xsd:string

[Term]
id: HP:0001920
name: Renal Artery Stenosis
def: "The presence of stenosis of the renal artery." []
synonym: "Narrowing of Kidney Artery" EXACT []
synonym: "RAS" EXACT []
xref: HP:0001920
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0001920
property_value: SCDO:0000468 "If due to FMD, presents at younger age, typically between 25-50 (and more common in women); if related to atherosclerotic disase, more likely to present after age 50." xsd:string
property_value: SCDO:0000661 "May be caused by atherosclerotic disease, fibromuscular dysplasia." xsd:string
property_value: SCDO:0000662 "Reduced blood flow through the renal arteries, large and branching vessels." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000982 xsd:string

[Term]
id: HP:0001923
name: Reticulocytosis
def: "An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation." []
synonym: "High Reticulocyte Count" EXACT []
synonym: "Increased Immature Red Blood Cells" EXACT []
synonym: "Increased Number of Immature Red Blood Cells" EXACT []
synonym: "Increased Reticulocyte Count" EXACT []
synonym: "Increased Reticulocytes" EXACT []
xref: HP:0001923
is_a: HP:0004312 ! Abnormality of Reticulocytes
relationship: SCDO:1000202 SCDO:0009350 ! caused by Splenic Sequestration
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
property_value: SCDO:0000340 HP:0001923
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001272 xsd:string

[Term]
id: HP:0001931
name: Hypochromic Anemia
def: "A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes." []
xref: HP:0001931
is_a: HP:0001903 ! Anemia
property_value: SCDO:0000340 HP:0001931
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007371 xsd:string

[Term]
id: HP:0001935
name: Microcytic Anemia
def: "A kind of anemia in which the volume of the red blood cells is reduced." []
comment: In normocytic anemia, the mean corpuscular volume (MCV) is below normal limits (>80 fl in adults).
xref: HP:0001935
is_a: HP:0001903 ! Anemia
property_value: http://purl.org/dc/elements/1.1/source HP:0001935
property_value: SCDO:0000340 HP:0001935
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008538 xsd:string

[Term]
id: HP:0001943
name: Hypoglycemia
def: "A decreased concentration of glucose in the blood." []
synonym: "Low Blood Sugar" EXACT []
xref: HP:0001943
is_a: HP:0011014 ! Abnormal Glucose Homeostasis
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001943 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000599 xsd:string

[Term]
id: HP:0001953
name: Diabetic Ketoacidosis
def: "A type of diabetic metabolic abnormality with an accumulation of ketone bodies." []
synonym: "Diabetic Ketosis" EXACT []
xref: HP:0001953
is_a: HP:0000819 ! Diabetes Mellitus
relationship: SCDO:0000664 SCDO:0000576 ! treated with Hydration Therapy
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001953 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000369 xsd:string

[Term]
id: HP:0001970
name: Interstitial Nephritis
def: "A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules." []
synonym: "Tubulointerstitial Nephritis" EXACT []
xref: HP:0001970
is_a: HP:0000123 ! Nephritis
relationship: SCDO:0000663 NCIT:C17241 ! diagnosed using tool Urine Test
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 HP:0001970
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000652 xsd:string

[Term]
id: HP:0001974
name: Leukocytosis
def: "An abnormal increase in the number of leukocytes in the blood." []
synonym: "Elevated White Blood Count" EXACT []
synonym: "High White Blood Count" EXACT []
synonym: "Increased Blood Leukocyte Number" EXACT []
xref: HP:0001974
is_a: HP:0011893 ! Abnormal Leukocyte Count
property_value: SCDO:0000340 HP:0001974
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005790 xsd:string

[Term]
id: HP:0001977
name: Abnormal Thrombosis
def: "Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis)." []
xref: HP:0001977
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
property_value: SCDO:0000340 HP:0001977
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000287 xsd:string

[Term]
id: HP:0001999
name: Facial Dysmorphisms
def: "An abnormal morphology (form) of the face or its components." []
synonym: "Abnormal facial shape" EXACT []
synonym: "Abnormal Morphology of the Face" EXACT []
synonym: "Dysmorphic Facial Features" EXACT []
synonym: "Unusual Facial Appearance" EXACT []
xref: HP:0001999
is_a: HP:0000271 ! Abnormality of the Face
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001999 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001314 xsd:string

[Term]
id: HP:0002007
name: Frontal Bossing
def: "Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline." []
synonym: "Frontal Protruberance" EXACT []
synonym: "Skull Bossing" EXACT []
xref: HP:0002007
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002007 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001337 xsd:string

[Term]
id: HP:0002014
name: Diarrhea
def: "Abnormally increased frequency of loose or watery bowel movements." []
synonym: "Diarrhoea" EXACT []
synonym: "Watery stool" EXACT []
xref: HP:0002014
is_a: HP:0025031 ! Abnormality of the Digestive System
property_value: SCDO:0000340 HP:0002014
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008043 xsd:string

[Term]
id: HP:0002019
name: Constipation
def: "Infrequent or difficult evacuation of feces." []
synonym: "Constipation" EXACT []
synonym: "Costiveness" EXACT []
synonym: "Dyschezia" EXACT []
xref: HP:0002019
is_a: HP:0025031 ! Abnormality of the Digestive System
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002019 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003263 xsd:string

[Term]
id: HP:0002059
name: Cerebral Atrophy
def: "Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum." []
comment: Atrophy may be progressive over time.
synonym: "Cortical Atrophy" EXACT []
synonym: "Degeneration of Cerebrum" EXACT []
synonym: "Supratentorial Atrophy" EXACT []
xref: HP:0002059
is_a: HP:0002060 ! Abnormality of the Cerebrum
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002059 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000203 xsd:string

[Term]
id: HP:0002060
name: Abnormality of the Cerebrum
def: "An abnormality of the telencephalon, which is also known as the cerebrum." []
synonym: "Abnormal Cerebral Morphology" EXACT []
synonym: "Abnormality of the Telencephalon" EXACT []
xref: HP:0002060
is_a: HP:0012639 ! Abnormal Nervous System Morphology
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002060 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008895 xsd:string

[Term]
id: HP:0002067
name: Bradykinesia
def: "Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement)." []
synonym: "Slow Movements" EXACT []
synonym: "Slowness of Movements" EXACT []
xref: HP:0002067
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002067 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000158 xsd:string

[Term]
id: HP:0002071
name: Extrapyramidal Symptoms
def: "A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless)." []
synonym: "Abnormality of Extrapyramidal Motor Function" EXACT []
synonym: "Extrapyramidal Dysfunction" EXACT []
synonym: "Extrapyramidal Signs" EXACT []
synonym: "Extrapyramidal Syndrome" EXACT []
synonym: "Extrapyramidal Tract Signs" EXACT []
xref: HP:0002071
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C74954 ! diagnosed using tool Liver Function Test
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0001322 ! diagnosed using tool Serum Ferritin Test
property_value: SCDO:0000340 HP:0002071
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001311 xsd:string

[Term]
id: HP:0002076
name: Migraine
def: "Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms." []
comment: Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances. Migraine in some women may relate to changes in hormones and hormonal levels during their menstrual cycle. For many years, scientists believed that migraines were linked to the dilation and constriction of blood vessels in the head. Investigators now believe that migraine has a genetic cause.
synonym: "Intermittent Migraine Headaches" EXACT []
synonym: "Migraine Headache" EXACT []
xref: HP:0002076
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000663 OGMS:0000088 ! diagnosed using tool Patient Symptom Report
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:0000664 SCDO:0000067 ! treated with Antihypertensive Agents
relationship: SCDO:0000664 SCDO:0000382 ! treated with Diet, Food, and Nutrition
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 HP:0002076
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000759 xsd:string

[Term]
id: HP:0002086
name: Abnormality of the Respiratory System
def: "An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles." []
synonym: "Respiratory Abnormality" EXACT []
xref: HP:0002086
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000303 "Curation completed by the SCDO curator team: Amy and Khuthala." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002086 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004899 xsd:string

[Term]
id: HP:0002090
name: Pneumonia
def: "Inflammation of any part of the lung parenchyma." []
xref: HP:0002090
is_a: HP:0002086 ! Abnormality of the Respiratory System
is_a: HP:0002715 ! Abnormality of the Immune System
property_value: SCDO:0000340 HP:0002090
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009838 xsd:string

[Term]
id: HP:0002098
name: Respiratory Distress
def: "Difficulty in breathing. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea." []
synonym: "Breathing Difficulties" EXACT []
synonym: "Difficulty Breathing" EXACT []
synonym: "Respiratory Difficulties" EXACT []
xref: HP:0002098
is_a: HP:0002086 ! Abnormality of the Respiratory System
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Is a symptom of acute chest syndrome" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002098 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009656 xsd:string

[Term]
id: HP:0002138
name: Subarachnoid Hemorrhage
def: "Hemorrhage occurring between the arachnoid mater and the pia mater." []
comment: Subarachnoid hemorrhage may occur spontaneously, usually from a ruptured cerebral aneurysm, or may result from head injury.
synonym: "Subarachnoid Haemorrhage" EXACT []
xref: HP:0002138
is_a: HP:0002170 ! Intracranial Hemorrhage
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:0000664 SCDO:0001159 ! treated with Tobacco Use Cessation
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 HP:0002138
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001118 xsd:string

[Term]
id: HP:0002149
name: Hyperuricemia
def: "An abnormally high level of uric acid in the blood." []
synonym: "High Blood Uric Acid Level" EXACT []
synonym: "Hyperuricaemia" EXACT []
xref: HP:0002149
is_a: HP:0002157 ! Azotaemia
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 HP:0002149
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000596 xsd:string

[Term]
id: HP:0002157
name: Azotaemia
def: "An increased concentration of nitrogen compounds in the blood." []
synonym: "Azotemia" EXACT []
xref: HP:0002157
is_a: HP:0004364 ! Abnormal Circulating Nitrogen Compound Concentration
relationship: SCDO:0000664 SCDO:0000983 ! treated with Renal Dialysis
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000303 "Perhaps move to below \"Endocrine and Metabolic\"? --  -- Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0002157
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000093 xsd:string

[Term]
id: HP:0002164
name: Nail Dysplasia
def: "The presence of developmental dysplasia of the nail." []
synonym: "Dysplastic Nails" EXACT []
synonym: "Onychodysplasia" EXACT []
xref: HP:0002164
is_a: HP:0001574 ! Abnormality of the Integument
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000340 HP:0002164
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000830 xsd:string

[Term]
id: HP:0002170
name: Intracranial Hemorrhage
def: "Hemorrhage occurring within the skull." []
xref: HP:0002170
is_a: SCDO:1000037 ! Abnormality of the Cerebral Vasculature
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0001327 ! diagnosed using tool Fluorescein Angiography
relationship: SCDO:0000664 SCDO:0000067 ! treated with Antihypertensive Agents
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1000220 SCDO:0001249 ! diagnosed using measurement X-Ray Image
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 HP:0002170
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000654 xsd:string

[Term]
id: HP:0002181
name: Cerebral Edema
def: "Abnormal accumulation of fluid in the brain." []
synonym: "Brain Edema" EXACT []
synonym: "Brain Oedema" EXACT []
synonym: "Cerebral Oedema" EXACT []
xref: HP:0002181
is_a: HP:0000969 ! Edema
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002181 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000207 xsd:string

[Term]
id: HP:0002204
name: Pulmonary Embolism
def: "An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery." []
synonym: "Blood Clot in Artery of Lung" EXACT []
xref: HP:0002204
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
property_value: SCDO:0000340 HP:0002204
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007912 xsd:string

[Term]
id: HP:0002240
name: Hepatomegaly
def: "Abnormally increased size of the liver." []
xref: HP:0002240
is_a: HP:0001392 ! Abnormality of the Liver
is_a: NCIT:C115224 ! Hepatic Complication
property_value: SCDO:0000340 HP:0002240
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005566 xsd:string

[Term]
id: HP:0002341
name: Cervical Cord Compression
def: "Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness." []
synonym: "Cervical Cord Compression Myelopathy" EXACT []
synonym: "Cervical Spondylotic Myelopathy" EXACT []
synonym: "Spinal Cord Compression" EXACT []
xref: HP:0002341
is_a: HP:0012639 ! Abnormal Nervous System Morphology
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 SCDO:0000963 ! diagnosed using tool Radiography
relationship: SCDO:0000664 NCIT:C561 ! treated with Ibuprofen
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1000220 SCDO:0001249 ! diagnosed using measurement X-Ray Image
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002341 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000214 xsd:string

[Term]
id: HP:0002427
name: Motor Aphasia
def: "Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it." []
synonym: "Broca's Aphasia" EXACT []
synonym: "Expressive Aphasia" EXACT []
synonym: "Loss of Expressive Speech" EXACT []
xref: HP:0002427
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000340 HP:0002427
property_value: SCDO:0000468 "Aphasia is one of the most common communication disorders to affect the brain. Although there are no official figures, the Stroke Association estimates more than 376,000 stroke survivors in the UK are living with aphasia. Aphasia can affect people of all ages, including children. It's most common in people over 65 years old as stroke and common progressive neurological conditions tend to affect older adults" xsd:string
property_value: SCDO:0000661 "Aphasia is caused by damage to parts of the brain responsible for understanding and using language. Common causes include:stroke, thought to be the most common cause, around one in three people experience some degree of aphasia after having a stroke.severe head injury. brain tumour.progressive neurological conditions (conditions that over time cause progressive brain and nervous system damage)." xsd:string
property_value: SCDO:0000662 "Experience difficulties with understanding or expressing language." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000773 xsd:string

[Term]
id: HP:0002516
name: Intracranial Hypertension
def: "An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid." []
synonym: "Increased Intracranial Pressure" EXACT []
synonym: "Intracranial Pressure Elevation" EXACT []
synonym: "Rise in Pressure Inside Skull" EXACT []
xref: HP:0002516
is_a: HP:0000822 ! Hypertension
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002516 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000655 xsd:string

[Term]
id: HP:0002597
name: Abnormality of the Vasculature
def: "An abnormality of the vasculature." []
xref: HP:0002597
is_a: HP:0001626 ! Abnormality of Cardiovascular System
property_value: SCDO:0000340 HP:0002597
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000373 xsd:string

[Term]
id: HP:0002650
name: Scoliosis
def: "The presence of an abnormal lateral curvature of the spine." []
synonym: "Abnormal Curving of the Spine" EXACT []
xref: HP:0002650
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002650 xsd:string
property_value: SCDO:0000661 "Congenital vertebral anomalies, idiopathic, result of a neuromuscular condition." xsd:string
property_value: SCDO:0000662 "Spinal tortuosity." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001026 xsd:string

[Term]
id: HP:0002653
name: Bone Pain
def: "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone." []
xref: HP:0002653
is_a: SCDO:0000851 ! Pain
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002653 xsd:string
property_value: SCDO:0000661 "A number of diseases may cause bone pain including osteoarthritis, Paget's disease, sickle cell anemia, and bone cancer. Acute leukemia;Acute rheumatic fever, a very dangerous disease that can cause permanent cardiac damage. Bursitis;Fibromyalgia like disease has been studied as a cause of joint pain in the child.Hypermobility syndrome can present with knee or ankle pain;Injury such as a fracture. Juvenile rheumatoid arthritis;Lupus;Lyme disease, which is transmitted by ticks and is characterized by debilatating polyarthritis, neurologic symptoms, and erythema migrans.;Osteomyelitis;Osteosarcoma.Septic arthritis, a severe infection of the joint that can lead to permanent joint damage.Synovitis;Viral diseases, including the measles, influenza, mononucleosis, chickenpox, and mumps." xsd:string
property_value: SCDO:0000662 "Stimulation of specialized pain-sensitive nerve fibers (nociceptors) that innervate bone tissue leads to the sensation of bone pain. Bone pain originates from both the periosteum and the bone marrow which relay nociceptive signals to the brain creating the sensation of pain. Bone tissue is innervated by both myelinated (A beta and A delta fiber) and unmyelinated (C fiber) sensory neurons. In combination, they can provide an initial burst of pain, initiated by the faster myelinated fibers, followed by a slower and longer lasting dull pain initiated by unmyelinated fibers" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000154 xsd:string

[Term]
id: HP:0002659
name: Bone Fragility
def: "An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture." []
synonym: "Abnormal Susceptibility to Fractures" EXACT []
synonym: "Frequent Broken Bones" EXACT []
synonym: "Increased Bone Fragility" EXACT []
synonym: "Increased Susceptibility to Fractures" EXACT []
synonym: "Increased Tendency to Fractures" EXACT []
xref: HP:0002659
is_a: HP:0000924 ! Abnormality of the Skeletal System
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002659 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000153 xsd:string

[Term]
id: HP:0002665
name: Lymphoma
def: "A cancer originating in lymphocytes and presenting as a solid tumor of lymphoid cells." []
synonym: "Cancer of Lymphatic System" EXACT []
xref: HP:0002665
is_a: OBI:1110053 ! Cancer
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002665 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000707 xsd:string

[Term]
id: HP:0002715
name: Abnormality of the Immune System
def: "An abnormality of the immune system." []
xref: HP:0002715
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000303 "Include as sub-class:\nAcquired Immunodeficiency Syndrome (term in NCIT)" xsd:string
property_value: SCDO:0000340 HP:0002715
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000273 xsd:string

[Term]
id: HP:0002725
name: Systemic Lupus Erythematosus
def: "A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes." []
xref: HP:0002725
is_a: SCDO:0000267 ! Comorbid Disease
relationship: SCDO:0000663 CMO:0000364 ! diagnosed using tool Complete Blood Count
relationship: SCDO:0000663 NCIT:C17241 ! diagnosed using tool Urine Test
relationship: SCDO:0000663 SCDO:0000217 ! diagnosed using tool Chest X-Ray
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:0000709 ! treated with Malaria Prophylaxis
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002725 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001137 xsd:string

[Term]
id: HP:0002808
name: Kyphosis
def: "Exaggerated anterior convexity of the thoracic vertebral column." []
synonym: "Gibbus Deformity" EXACT []
synonym: "Hunched Back" EXACT []
synonym: "Hyperkyphosis" EXACT []
synonym: "Round Back" EXACT []
xref: HP:0002808
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002808 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000679 xsd:string

[Term]
id: HP:0002829
name: Arthralgia
def: "Joint pain." []
synonym: "Arthralgias" EXACT []
synonym: "Joint pain" EXACT []
xref: HP:0002829
is_a: SCDO:0000851 ! Pain
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002829 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000074 xsd:string

[Term]
id: HP:0002870
name: Obstructive Sleep Apnea
def: "A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow." []
synonym: "Obstructive Sleep Apnoea" EXACT []
xref: HP:0002870
is_a: HP:0000708 ! Behavioural Abnormality
relationship: SCDO:0000663 SCDO:0000417 ! diagnosed using tool Electrocardiography
relationship: SCDO:0000663 SCDO:0000420 ! diagnosed using tool Electroencephalography
relationship: SCDO:0000663 SCDO:0000945 ! diagnosed using tool Pulse Oximetry (Rest)
relationship: SCDO:0000664 SCDO:0000498 ! treated with Healthy Lifestyle
relationship: SCDO:0000664 SCDO:0000689 ! treated with Lifestyle
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002870 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000820 xsd:string

[Term]
id: HP:0002907
name: Microscopic Hematuria
def: "Microscopic hematuria detected by dipstick or microscopic examination of the urine." []
synonym: "Microhematuria" EXACT []
synonym: "Occult Hematuria" EXACT []
synonym: "Small Amount of Blood in Urine" EXACT []
xref: HP:0002907
is_a: SCDO:0000508 ! Hematuria
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002907 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004833 xsd:string

[Term]
id: HP:0002913
name: Myoglobinuria
def: "Presence of myoglobin in the urine." []
synonym: "Increased Urine Myoglobin Level" EXACT []
xref: HP:0002913
is_a: HP:0000079 ! Abnormality of the Urinary System
relationship: SCDO:0000664 SCDO:0000983 ! treated with Renal Dialysis
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
property_value: SCDO:0000340 HP:0002913
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000783 xsd:string

[Term]
id: HP:0002955
name: Granulomatosis
def: "Any disease characterized by the formation of numerous granulomas." []
comment: Has disease stages: Allergic (Churg-strauss syndrome), eosinophilic (langerhan cell histiocytosis), langerhans (langerhan cell histiocytosis), lymphomatoid, siderotica, wegeners.\n\nIs caused by: Genetic predispositions, autoimmune mediated, chronic inflammation.
xref: HP:0002955
is_a: IDO:0000586 ! Infection
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000303 "Source needed for additional information." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002955 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000464 xsd:string

[Term]
id: HP:0003077
name: Hyperlipidemia
def: "An elevated lipid concentration in the blood." []
synonym: "Elevated Lipids in Blood" EXACT []
xref: HP:0003077
is_a: HP:0003611 ! Dyslipidemia
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0003077 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000590 xsd:string

[Term]
id: HP:0003110
name: Abnormal Urine Homeostasis
def: "An abnormality of the composition of urine or the levels of its components." []
synonym: "Abnormal Urine Chemistry" EXACT []
synonym: "Abnormality of Urine Homeostasis" EXACT []
xref: HP:0003110
is_a: HP:0000079 ! Abnormality of the Urinary System
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
property_value: SCDO:0000340 HP:0003110
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000651 xsd:string

[Term]
id: HP:0003116
name: Abnormal Echocardiogram
def: "An abnormality detectable by sonography of the heart (echocardiography)." []
synonym: "Abnormal ECG" EXACT []
synonym: "Abnormal Echocardiography" EXACT []
xref: HP:0003116
is_a: HP:0500015 ! Abnormal Cardiac Test
property_value: SCDO:0000340 HP:0003116
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000267 xsd:string

[Term]
id: HP:0003126
name: Tubular Proteinuria
def: "Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD)." []
synonym: "Low-Molecular-Weight Proteinuria" EXACT []
xref: HP:0003126
is_a: SCDO:0000932 ! Proteinuria
relationship: SCDO:0000664 SCDO:0000055 ! treated with Angiotensin-Converting Enzyme Inhibitors
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0003126 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001196 xsd:string

[Term]
id: HP:0003155
name: Elevated Serum Alkaline Phosphatase
def: "Abnormally increased serum levels of alkaline phosphatase activity." []
synonym: "Blood Alkaline Phosphatase Increased" EXACT []
synonym: "Decreased Circulating Alkaline Phosphatase Level" EXACT []
synonym: "Elevated Alkaline Phosphatase" EXACT []
synonym: "Elevated ALP" EXACT []
synonym: "High Serum Alkaline Phosphatase" EXACT []
synonym: "Increased Alkaline Phosphatase" EXACT []
synonym: "Reduced Circulating ALP" EXACT []
xref: HP:0003155
is_a: HP:0004379 ! Abnormality of Alkaline Phosphatase Level
property_value: SCDO:0000340 HP:0003155
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000664 xsd:string

[Term]
id: HP:0003158
name: Hyposthenuria
def: "An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine." []
comment: Urine specific gravity is lower than that of plasma < 1.008.
xref: HP:0003158
is_a: HP:0004727 ! Impaired Renal Concentrating Ability
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "Could this be a synonym for 'Impaired Urinary Concentration' (SCDO:0000621)?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0003158 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008046 xsd:string

[Term]
id: HP:0003198
name: Myopathy
def: "A disorder of muscle unrelated to impairment of innervation or neuromuscular junction." []
synonym: "Muscle Tissue Disease" EXACT []
synonym: "Myopathic Changes" EXACT []
synonym: "Myopathies" EXACT []
xref: HP:0003198
is_a: SCDO:1000268 ! Abnormality of the Musculature
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0003198 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000784 xsd:string

[Term]
id: HP:0003265
name: Neonatal Hyperbilirubinemia
def: "A type of hyperbilirubinemia with neonatal onset." []
synonym: "High Blood Bilirubin Levels in Neonate" EXACT []
xref: HP:0003265
is_a: NCIT:C27088 ! Hyperbilirubinemia
property_value: SCDO:0000340 HP:0003265
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003776 xsd:string

[Term]
id: HP:0003282
name: Decreased Serum Alkaline Phosphatase
def: "Abnormally reduced serum levels of alkaline phosphatase." []
synonym: "Low Alkaline Phosphatase" EXACT []
synonym: "Low ALP" EXACT []
synonym: "Reduced Serum Alkaline Phosphatase" EXACT []
xref: HP:0003282
is_a: HP:0004379 ! Abnormality of Alkaline Phosphatase Level
property_value: SCDO:0000340 HP:0003282
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000667 xsd:string

[Term]
id: HP:0003302
name: Spondylolisthesis
def: "Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra." []
synonym: "Displacement of One Backbone Compared to Another" EXACT []
synonym: "Slipped Backbone" EXACT []
synonym: "Spondylolithesis" EXACT []
xref: HP:0003302
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0003302 xsd:string
property_value: SCDO:0000661 "Spondylolysis, arthritis, degeneration, trauma, metastases or metabolic bone disease, congenital." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001102 xsd:string

[Term]
id: HP:0003394
name: Muscle Cramps
def: "Sudden and involuntary contractions of one or more muscles." []
synonym: "Muscle Spasm" EXACT []
xref: HP:0003394
is_a: SCDO:1000268 ! Abnormality of the Musculature
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 HP:0003394
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000778 xsd:string

[Term]
id: HP:0003418
name: Back Pain
def: "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back." []
xref: HP:0003418
is_a: SCDO:0000851 ! Pain
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0003418
property_value: SCDO:0000661 "muscle strain, trauma, surgery, fracture, osteoporosis, fibromialgia, spinal disc herniation." xsd:string
property_value: SCDO:0000662 "Pain in the lower back." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000095 xsd:string

[Term]
id: HP:0003457
name: EMG Abnormality
def: "Abnormal results of investigations using electromyography (EMG)." []
synonym: "Abnormal Electromyography (EMG)." EXACT []
synonym: "Abnormal Electromyography Finding" EXACT []
synonym: "Abnormal EMG" EXACT []
synonym: "Electromyogram Abnormal" EXACT []
synonym: "EMG Abnormalities" EXACT []
xref: HP:0003457
is_a: SCDO:1000268 ! Abnormality of the Musculature
property_value: SCDO:0000340 HP:0003457
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000428 xsd:string

[Term]
id: HP:0003470
name: Paralysis
def: "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Motor paralysis is often accompanied by an impairment in the facility of movement." []
synonym: "Inability to Move" EXACT []
xref: HP:0003470
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0003470 xsd:string
property_value: SCDO:0000661 "Most paralysis is due to strokes or injuries such as spinal cord injury or a broken neck. Other causes of paralysis include: Nerve diseases such as amyotrophic lateral sclerosis, Autoimmune diseases such as Guillain-Barre syndrome, Bell's palsy, which affects muscles in the face, Polio used to be a cause of paralysis, but polio no longer occurs in the U.S." xsd:string
property_value: SCDO:0000662 "Paralysis can be complete or partial. It can occur on one or both sides of your body. It can also occur in just one area, or it can be widespread. Paralysis of the lower half of your body, including both legs, is called paraplegia. Paralysis of the arms and legs is quadriplegia." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000865 xsd:string

[Term]
id: HP:0003563
name: Decreased Circulating LDL Cholesterol Level
def: "Reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions." []
synonym: "Decreased Circulating Low-Density Lipoprotein Levels" EXACT []
synonym: "Decreased LDL" EXACT []
synonym: "Decreased LDL Cholesterol Concentration" EXACT []
synonym: "Decreased LDL Cholesterol Level" EXACT []
synonym: "Decreased LDLc Concentration" EXACT []
synonym: "Low Circulating LDL Cholesterol Level" EXACT []
synonym: "Low LDL-Cholestrol Levels" EXACT []
synonym: "Reduced Circulating LDL Cholesterol Level" EXACT []
xref: HP:0003563
is_a: HP:0003611 ! Dyslipidemia
property_value: SCDO:0000340 MP:0000183
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000703 xsd:string

[Term]
id: HP:0003573
name: Increased Total Bilirubin
def: "Increased concentration of total (conjugated and unconjugated) bilirubin in the blood." []
synonym: "High Bili Total" EXACT []
synonym: "High Total Bilirubin" EXACT []
synonym: "Increased Bilirubin" EXACT []
xref: HP:0003573
is_a: NCIT:C27088 ! Hyperbilirubinemia
property_value: SCDO:0000340 HP:0003573
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000681 xsd:string

[Term]
id: HP:0003611
name: Dyslipidemia
def: "Anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood." []
synonym: "Abnormal Circulating Lipid Concentration" EXACT []
synonym: "Abnormal Circulating Lipid Level" EXACT []
synonym: "Dyslipidaemia" EXACT []
xref: HP:0003611
is_a: MP:0002118 ! Abnormal Lipid Homeostasis
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:0000664 SCDO:0000498 ! treated with Healthy Lifestyle
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MP_0003949 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000404 xsd:string

[Term]
id: HP:0003641
name: Hemoglobinuria
def: "The presence of free hemoglobin in the urine." []
comment: If, following hemolysis, haptoglobins (hemoglobin-binding proteins) are saturated, then free hemoglobin appears in the urine.
synonym: "Increased Urine Hemoglobin Level" EXACT []
xref: HP:0003641
is_a: HP:0000077 ! Abnormality of the Kidney
is_a: SCDO:1000383 ! Renal Complication
relationship: SCDO:0000663 NCIT:C17241 ! diagnosed using tool Urine Test
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 HP:0003641
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000554 xsd:string

[Term]
id: HP:0003765
name: Psoriasis
def: "A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales)." []
synonym: "Psoriasiform Dermatitis" EXACT []
xref: HP:0003765
is_a: HP:0011122 ! Abnormality of Skin Physiology
property_value: SCDO:0000340 HP:0003765
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000936 xsd:string

[Term]
id: HP:0003774
name: End Stage Kidney Disease
def: "A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine, greater than 3 months." []
synonym: "End Stage Renal Disease" EXACT []
synonym: "End Stage Renal Disease (ESRD)" EXACT []
synonym: "End Stage Renal Failure" EXACT []
synonym: "End-Stage Renal Disease" EXACT []
synonym: "End-Stage Renal Failure" EXACT []
synonym: "ESKD" EXACT []
synonym: "ESRD" EXACT []
synonym: "Stage 5 Chronic Kidney Disease" EXACT []
xref: HP:0003774
is_a: SCDO:0000226 ! Chronic Kidney Disease
relationship: SCDO:0000664 SCDO:0000983 ! treated with Renal Dialysis
relationship: SCDO:0000664 SCDO:0000985 ! treated with Renal Transplant
relationship: SCDO:1000219 SCDO:0000588 ! diagnosed by Hyperkalemia
relationship: SCDO:1000220 CMO:0000057 ! diagnosed using measurement Serum Creatinine Level
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0003774
property_value: SCDO:0000468 "Variable" xsd:string
property_value: SCDO:0000661 "Final outcome of any form of kidney disease ; may be caused by diabetes, hypertension, glomerular disease, polycystic kidney disease, sickle cell disease, chronic toxic injury." xsd:string
property_value: SCDO:0000662 "Elevated serum creatinine, uremia, acidosis, hyperkalemia, hyperphosphatemia, secondary hyperpararthyroidism, anemia, hypertension, fluid retention." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000430 xsd:string

[Term]
id: HP:0004312
name: Abnormality of Reticulocytes
def: "A reticulocyte abnormality." []
xref: HP:0004312
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
property_value: SCDO:0000340 HP:0004312
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000265 xsd:string

[Term]
id: HP:0004364
name: Abnormal Circulating Nitrogen Compound Concentration
def: "Any deviation from the normal concentration of a nitrogen compound in the blood circulation." []
xref: HP:0004364
is_a: HP:0032180 ! Abnormal Circulating Metabolite Concentration
property_value: SCDO:0000340 HP:0004364
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000647 xsd:string

[Term]
id: HP:0004379
name: Abnormality of Alkaline Phosphatase Level
def: "An abnormality of alkaline phosphatase level." []
comment: Note that the alkaline phosphatase family has four isoenzymes in humans, each of which additionally can have different isoforms. The primary clinical importance of measuring alkaline phosphatase is to check the possibility of bone disease or liver disease.
synonym: "Abnormality Alkaline Phosphatase Level" EXACT []
synonym: "Abnormality of Alkaline Phosphatase Activity" EXACT []
synonym: "Abnormality of ALP Level" EXACT []
synonym: "Alkaline Phosphatase Abnormal" EXACT []
xref: HP:0004379
is_a: HP:0012379 ! Abnormal Enzyme/Coenzyme Activity
property_value: SCDO:0000340 HP:0004379
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000666 xsd:string

[Term]
id: HP:0004447
name: Poikilocytosis
def: "The presence of abnormally shaped erythrocytes." []
xref: HP:0004447
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
property_value: SCDO:0000340 HP:0004447
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000245 xsd:string

[Term]
id: HP:0004586
name: Biconcave Vertebral Bodies
def: "Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward." []
synonym: "Biconcave Vertebrae" EXACT []
synonym: "Fish Mouth Deformity" EXACT []
synonym: "Fish Vertebrae" EXACT []
synonym: "Step Vertebrae" EXACT []
xref: HP:0004586
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
property_value: SCDO:0000340 HP:0004586
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000118 xsd:string

[Term]
id: HP:0004727
name: Impaired Renal Concentrating Ability
def: "A defect in the ability to concentrate the urine." []
synonym: "UCD" EXACT []
synonym: "Urine Concentrating Defect" EXACT []
synonym: "Urine Concentration Defect" EXACT []
xref: HP:0004727
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0004727 xsd:string
property_value: SCDO:0000468 "Notable within the first decade of life." xsd:string
property_value: SCDO:0000661 "Can be caused by tubular damage in the kidney; can be seen in sickle cell disease and sickle cell trait." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000621 xsd:string

[Term]
id: HP:0004756
name: Ventricular Tachycardia
def: "A tachycardia originating in the ventricles characterized by rapid heart rate (over 100 beats per minute) and broad QRS complexes (over 120 ms)." []
comment: Ventricular tachycardia (VT) is a potentially life-threatening ventricular arrhythmia that presents as a wide QRS complex tachycardia, and is defined as three or more consecutive QRS complexes with a duration longer than 120 milliseconds (ms) and a rate of 100 beats per minute or more, whereby the complexes have a ventricular origin. VT can be subdivided as follows: (i) sustained VT persists for 30 seconds or more; (ii) non-sustained VT lasts less than 30 seconds; (iii) monomorphic VT displays a uniform QRS morphology; and (iv) polymorphic VT displays QRS morphologies that variy from beat to beat. VT is observed most commonly in individuals with structural heart disease or acute myocardial infarction (MI). VT may also be observed in in the setting of drug toxicity or electrolyte abnormalities or in individuals with Mendelian disease.
synonym: "VT" EXACT []
xref: HP:0004756
is_a: SCDO:0001851 ! Tachycardia
property_value: http://purl.org/dc/elements/1.1/source HP:0004756
property_value: SCDO:0000340 HP:0004756
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003769 xsd:string

[Term]
id: HP:0004825
name: Increased Hemoglobin Oxygen Affinity
def: "An abnormal increase in the binding affinity of hemoglobin for oxygen." []
synonym: "Increased Haemoglobin Oxygen Affinity" EXACT []
xref: HP:0004825
is_a: HP:0020054 ! Abnormal Erythrocyte Physiology
property_value: SCDO:0000340 HP:0004825
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000248 xsd:string

[Term]
id: HP:0004870
name: Chronic Hemolytic Anemia
def: "A chronic form of hemolytic anemia." []
xref: HP:0004870
is_a: HP:0001878 ! Hemolytic Anemia
is_a: SCDO:0005167 ! Chronic Anemia
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0004870 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001248 xsd:string

[Term]
id: HP:0005162
name: Left Ventricular Dysfunction
def: "Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole." []
synonym: "Impaired Left Ventricular Function" EXACT []
synonym: "Left Ventricular Failure" EXACT []
synonym: "Left Ventricular Impairment" EXACT []
synonym: "Left-Sided Heart Failure" EXACT []
xref: HP:0005162
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0005162 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002710 xsd:string

[Term]
id: HP:0005268
name: Spontaneous Abortion
def: "A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 20th week of pregnancy." []
synonym: "Miscarriage" EXACT []
xref: HP:0005268
is_a: HP:0001787 ! Abnormal Delivery
is_a: NCIT:C34941 ! Pregnancy Complication
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 HP:0005268
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001103 xsd:string

[Term]
id: HP:0005305
name: Cerebral Venous Thrombosis
def: "Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow." []
synonym: "Blood Clot in Cerebral Vein" EXACT []
synonym: "Cerebral Thrombosis" EXACT []
synonym: "Cerebral Vein Thrombosis" EXACT []
xref: HP:0005305
is_a: HP:0001977 ! Abnormal Thrombosis
is_a: HP:0002060 ! Abnormality of the Cerebrum
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C17230 ! diagnosed using tool Ultrasound Test
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0001327 ! diagnosed using tool Fluorescein Angiography
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Add \"Cerebral Venous Sinus Thrombosis\" (in the Stroke Ontology) as a sub-class" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0005305 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000211 xsd:string

[Term]
id: HP:0005318
name: Cerebral Vasculitis
def: "Inflammation of the blood vessels within the brain." []
xref: HP:0005318
is_a: HP:0002060 ! Abnormality of the Cerebrum
relationship: SCDO:1000219 HP:0012229 ! diagnosed by Cerebrospinal Fluid Pleocytosis
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0005318 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000210 xsd:string

[Term]
id: HP:0005518
name: Increased Mean Corpuscular Volume
def: "Larger than normal size of erythrocytes. Macrocytosis refers to a mean cell volume (MCV) greater than 100 fL. If macrocytosis is an isolated abnormality, the amount of hemoglobin in the cell increases proportionately, so the mean cell hemoglobin concentration (MCHC) remains within normal limits." []
synonym: "Erythrocyte Macrocytosis" EXACT []
synonym: "High MCV" EXACT []
synonym: "Increased MCV" EXACT []
xref: HP:0005518
is_a: HP:0025065 ! Abnormal Mean Corpuscular Volume
property_value: SCDO:0000340 HP:0005518
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000626 xsd:string

[Term]
id: HP:0005560
name: Imbalanced Hemoglobin Synthesis
def: "Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia." []
xref: HP:0005560
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
is_a: SCDO:1000060 ! SCD Molecular Phenotype
relationship: SCDO:1000015 SCDO:0000042 ! modifies Alpha Thalassemia
relationship: SCDO:1000015 SCDO:0000251 ! modifies Clinical Phenotype of Beta Thalassemia
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0005560 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001383 xsd:string

[Term]
id: HP:0006689
name: Bacterial Endocarditis
def: "A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves." []
synonym: "Infective Endocarditis" EXACT []
xref: HP:0006689
is_a: NCIT:C2890 ! Bacterial Infection
relationship: SCDO:0000664 IDO:0000560 ! treated with Antifungal
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
property_value: http://purl.org/dc/elements/1.1/source HP:0006689
property_value: SCDO:0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000099 xsd:string

[Term]
id: HP:0007018
name: Attention Deficit Hyperactivity Disorder
def: "Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient." []
synonym: "ADHD" EXACT []
synonym: "Attention Deficit" EXACT []
synonym: "Attention Deficit Disorder" EXACT []
synonym: "Attention Deficit-Hyperactivity Disorder" EXACT []
synonym: "Attention Deficits" EXACT []
synonym: "Childhood Attention Deficit/Hyperactivity Disorder" EXACT []
xref: HP:0007018
is_a: HP:0000708 ! Behavioural Abnormality
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0007018 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000090 xsd:string

[Term]
id: HP:0007340
name: Leg Weakness
def: "Weakness of the muscles of the legs." []
comment: Inability to perform rapid, alternating movements.
synonym: "Hind Limb Weakness" EXACT []
synonym: "Hindlimb Weakness" EXACT []
synonym: "Leg Weakness" EXACT []
synonym: "Lower Extremity Weakness" EXACT []
synonym: "Lower Limb Muscle Weakness" EXACT []
synonym: "Lower Limb Weakness" EXACT []
synonym: "Muscle Weakness in Lower Limbs" EXACT []
xref: HP:0007340
is_a: HP:0025142 ! Constitutional Symptom
is_a: SCDO:1000268 ! Abnormality of the Musculature
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 HP:0007340
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000686 xsd:string

[Term]
id: HP:0007902
name: Vitreous Hemorrhage
def: "Bleeding within the vitreous compartment of the eye." []
synonym: "Hemorrage Within the Vitreous Humor" EXACT []
synonym: "Vitreous Haemorrhage" EXACT []
xref: HP:0007902
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:0000664 SCDO:0001237 ! treated with Vitrectomy
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 HP:0007902
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001238 xsd:string

[Term]
id: HP:0008245
name: Secondary Hypothyroidism
def: "A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion." []
synonym: "Thyroid Stimulating Hormone Deficiency" EXACT []
synonym: "Thyrotropin Deficiency" EXACT []
synonym: "TSH Deficient Hypothyroidism" EXACT []
xref: HP:0008245
is_a: HP:0000821 ! Hypothyroidism
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0008245 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001028 xsd:string

[Term]
id: HP:0008404
name: Nail Dystrophy
def: "Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate." []
synonym: "Dystrophic Nails" EXACT []
synonym: "Onychodystrophy" EXACT []
synonym: "Poor nail formation" EXACT []
xref: HP:0008404
is_a: HP:0001574 ! Abnormality of the Integument
relationship: SCDO:0000664 IDO:0000560 ! treated with Antifungal
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
property_value: SCDO:0000340 HP:0008404
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000788 xsd:string

[Term]
id: HP:0008682
name: Acute Tubular Necrosis
def: "Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis." []
synonym: "ATN" EXACT []
synonym: "Renal Tubular Necrosis" EXACT []
xref: HP:0008682
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:0000664 SCDO:0000983 ! treated with Renal Dialysis
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:1000220 CMO:0000057 ! diagnosed using measurement Serum Creatinine Level
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0008682
property_value: SCDO:0000468 "Can occur at any age." xsd:string
property_value: SCDO:0000472 "The clinical course of acute tubular necrosis may be divided into initiation, maintenance, and recovery phases." xsd:string
property_value: SCDO:0000661 "Renal ischemia (which can occur due to prolonged prerenal states), nephrotoxins, or sepsis. In sickle cell disease, may occur due to renal ischemia related to sickle crisis." xsd:string
property_value: SCDO:0000662 "Loss of kidney function, reduced urine output, elevated serum creatinine." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000020 xsd:string

[Term]
id: HP:0009045
name: Exercise-Induced Rhabdomyolysis
def: "Rhabdomyolysis induced by exercise." []
synonym: "Rhabdomyolysis with Exercise" EXACT []
xref: HP:0009045
is_a: SCDO:1000260 ! Symptom Induced by Strenuous Exercise
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:0000664 SCDO:1000004 ! treated with Renal Replacement Therapy
relationship: SCDO:1000199 NCIT:C16567 ! induced by Exercise
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0009045 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001308 xsd:string

[Term]
id: HP:0009830
name: Peripheral Neuropathy
def: "Peripheral neuropathy is a general term for any disorder of the peripheral nervous system." []
synonym: "Peripheral Nerve Damage" EXACT []
synonym: "Peripheral Neuritis" EXACT []
xref: HP:0009830
is_a: HP:0012639 ! Abnormal Nervous System Morphology
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 OGMS:0000088 ! diagnosed using tool Patient Symptom Report
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0000250 ! diagnosed using tool Clinical Neuropathy Assessment
relationship: SCDO:0000664 SCDO:0000382 ! treated with Diet, Food, and Nutrition
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: http://purl.org/dc/elements/1.1/source http://www.nlm.nih.gov/medlineplus/ency/article/000593.htm
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0009830 xsd:string
property_value: SCDO:0000662 "Symptoms depend on which nerve is damaged, and whether the damage affects one nerve, several nerves, or the whole body. Pain and numbness: Tingling or burning in the arms and legs may be an early sign of nerve damage. These feelings often start in your toes and feet. You may have deep pain. This often happens in the feet and legs. You may lose feeling in your legs and arms. Because of this, you may not notice when you step on something sharp. You may not notice when you touch something that is too hot or cold, like the water in a bathtub. You may not know when you have a small blister or sore on your feet. Numbness may make it harder to tell where your feet are moving and can cause a loss of balance. Muscle problems: Damage to the nerves can make it harder to control muscles. It can also cause weakness. You may notice problems moving a part of your body. You may fall because your legs buckle. You may trip over your toes. Doing tasks such as buttoning a shirt may be harder. You may also notice that your muscles twitch or cramp. Your muscles may become smaller. Problems with body organs: People with nerve damage may have problems digesting food. You may feel full or bloated and have heartburn after eating only a little food. Sometimes you may vomit food that has not been digested well. You may have either loose stools or hard stools. Some people have problems swallowing. Damage to the nerves to your heart may cause you to feel light-headed, or faint, when you stand up. Angina is the warning chest pain for heart disease and heart attack. Nerve damage may \"hide\" this warning sign. You should learn other warning signs of a heart attack. They are sudden fatigue, sweating, shortness of breath, nausea, and vomiting." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000884 xsd:string

[Term]
id: HP:0010628
name: Facial Nerve Palsy
def: "Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form." []
synonym: "Bell's Palsy" EXACT []
synonym: "Cranial Nerve VII Palsy" EXACT []
synonym: "Facial Muscle Weakness of Muscles Innervated by CN VII" EXACT []
synonym: "Facial Nerve Paralysis" EXACT []
synonym: "Facial Palsy" EXACT []
synonym: "Facial Paralysis" EXACT []
synonym: "Seventh Cranial Nerve Palsy" EXACT []
synonym: "VIIth Cranial Nerve Palsy" EXACT []
xref: HP:0010628
is_a: HP:0000271 ! Abnormality of the Face
relationship: SCDO:0000663 CMO:0000364 ! diagnosed using tool Complete Blood Count
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 OGMS:0000088 ! diagnosed using tool Patient Symptom Report
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 SCDO:0000822 ! treated with Occupational Therapy
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000219 HP:0001250 ! diagnosed by Seizure
property_value: SCDO:0000303 "- Provide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0010628
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001315 xsd:string

[Term]
id: HP:0010876
name: Abnormal Circulating Protein Level
def: "An abnormal level of a circulating protein in the blood." []
synonym: "Abnormality of Circulating Protein Level" EXACT []
synonym: "Blood Protein Disease" EXACT []
synonym: "Serum Protein Abnormality" EXACT []
xref: HP:0010876
is_a: HP:0032180 ! Abnormal Circulating Metabolite Concentration
property_value: SCDO:0000340 https://hpo.jax.org/app/browse/term/HP:0010876
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000438 xsd:string

[Term]
id: HP:0010885
name: Osteonecrosis
def: "A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply." []
comment: The interruption of the blood supply may have many different causes such as rapid growth, heredity causes, trauma or overuse, anatomic conformation, dietary imbalances or secondary effects of other diseases.
synonym: "Aseptic Bone Necrosis" EXACT []
synonym: "Aseptic necrosis" EXACT []
synonym: "Avascular Bone Necrosis" EXACT []
synonym: "Avascular Necrosis" EXACT []
synonym: "Avascular Necrosis (AVN)" EXACT []
synonym: "AVN" EXACT []
synonym: "Bone Infarction" EXACT []
synonym: "Bone Infarcts" EXACT []
synonym: "Bone Necrosis" EXACT []
synonym: "Ischemic Bone Necrosis" EXACT []
synonym: "Osteochondronecrosis" EXACT []
xref: HP:0010885
is_a: HP:0000924 ! Abnormality of the Skeletal System
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1000202 SCDO:0008623 ! caused by Vaso-Occlusion
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source HP:0010885
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MEDLINEPLUS/C0029445 xsd:string
property_value: SCDO:0000303 "No one is sure what causes the disease. Risk factors include: --  -- Long-term steroid treatment -- Alcohol abuse -- Joint injuries -- Having certain diseases, including arthritis and cancer -- Doctors use imaging tests and other tests to diagnose osteonecrosis.  --  -- Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery." xsd:string
property_value: SCDO:0000340 HP:0010885
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000841 xsd:string

[Term]
id: HP:0011001
name: Increased Bone Mineral Density
def: "An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often refered to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones." []
synonym: "Bone Sclerosis" EXACT []
synonym: "Increased Bone Density" EXACT []
synonym: "Osteosclerosis" EXACT []
synonym: "Osteosclerosis of Bones" EXACT []
xref: HP:0011001
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011001 xsd:string
property_value: SCDO:0000661 "Ischemia, chronic infection, and tumor formation, osteoarthritis, osteoma, hepatitis C, . May be caused by faulty bone resorption as a result of some abnormality involving osteoclasts." xsd:string
property_value: SCDO:0000662 "An increased whiteness (density) of affected bones." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000629 xsd:string

[Term]
id: HP:0011007
name: Age of Onset
def: "The age group in which disease manifestations appear." []
xref: HP:0011007
is_a: NCIT:C43646 ! Association
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011007 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003913 xsd:string

[Term]
id: HP:0011014
name: Abnormal Glucose Homeostasis
def: "Abnormality of glucose homeostasis." []
xref: HP:0011014
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
property_value: SCDO:0000340 HP:0011014
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000283 xsd:string

[Term]
id: HP:0011025
name: Abnormal Cardiovascular System Physiology
def: "Abnormal functionality of the cardiovascular system." []
xref: HP:0011025
is_a: HP:0001626 ! Abnormality of Cardiovascular System
property_value: SCDO:0000340 HP:0011025
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000368 xsd:string

[Term]
id: HP:0011106
name: Hypovolemia
def: "A decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood." []
synonym: "Depleted Blood Volume" EXACT []
xref: HP:0011106
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
property_value: SCDO:0000340 HP:0011106
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003035 xsd:string

[Term]
id: HP:0011121
name: Abnormality of Skin Morphology
def: "Any morphological abnormality of the skin." []
xref: HP:0011121
is_a: HP:0000951 ! Abnormality of the Skin
property_value: SCDO:0000340 HP:0011121
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000374 xsd:string

[Term]
id: HP:0011122
name: Abnormality of Skin Physiology
def: "Any abnormality of the physiological function of the skin." []
xref: HP:0011122
is_a: HP:0000951 ! Abnormality of the Skin
property_value: SCDO:0000340 HP:0011122
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000375 xsd:string

[Term]
id: HP:0011123
name: Skin Inflammation
def: "The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes." []
synonym: "Abnormal Tendency to Infections of the Skin" EXACT []
synonym: "Dermatitis" EXACT []
synonym: "Inflammatory Abnormality of the Skin" EXACT []
synonym: "Inflammatory Skin Disease" EXACT []
synonym: "Maculopapular Rash" EXACT []
xref: HP:0011123
is_a: HP:0011122 ! Abnormality of Skin Physiology
property_value: SCDO:0000340 HP:0011123
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001071 xsd:string

[Term]
id: HP:0011410
name: Caesarian Section
def: "Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy)." []
xref: HP:0011410
is_a: HP:0001787 ! Abnormal Delivery
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011410 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000168 xsd:string

[Term]
id: HP:0011413
name: Shoulder Dystocia
def: "Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex." []
xref: HP:0011413
is_a: HP:0001787 ! Abnormal Delivery
property_value: SCDO:0000340 HP:0011413
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001045 xsd:string

[Term]
id: HP:0011675
name: Arrhythmia
def: "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." []
synonym: "Abnormal Heart Rate" EXACT []
synonym: "Abnormality of Cardiac Conduction" EXACT []
synonym: "Arrhythmias" EXACT []
synonym: "Cardiac Arrhythmia" EXACT []
synonym: "Cardiac Arrhythmias" EXACT []
synonym: "Cardiac Conduction Abnormalities" EXACT []
synonym: "Cardiac Conduction Defects" EXACT []
synonym: "Cardiac Rhythm Disturbances" EXACT []
synonym: "Heart Rhythm Disorders" EXACT []
synonym: "Irregular Heart Beat" EXACT []
synonym: "Irregular Heartbeat" EXACT []
xref: HP:0011675
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011675 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009619 xsd:string

[Term]
id: HP:0011695
name: Cerebellar Hemorrhage
def: "Hemorrhage into the parenchyma of the cerebellum." []
xref: HP:0011695
is_a: HP:0002170 ! Intracranial Hemorrhage
property_value: SCDO:0000303 "Need to include this term mentioned here to the SCDO: -- obstructive hydrocephalus" xsd:string
property_value: SCDO:0000340 HP:0011695
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000201 xsd:string

[Term]
id: HP:0011856
name: Pica
def: "An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month." []
xref: HP:0011856
is_a: HP:0000708 ! Behavioural Abnormality
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011856 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000904 xsd:string

[Term]
id: HP:0011868
name: Sciatica
def: "Pain in the lower back and hip radiating in the distribution of the sciatic nerve." []
xref: HP:0011868
is_a: HP:0003418 ! Back Pain
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000303 "Provide source for additional info. \n\nTerms to add to therapeutics for linking via \"is treated with\" obj property: Local heat, acupuncture, physical therapy, surgery" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011868 xsd:string
property_value: SCDO:0000661 "Compression of a spinal nerve root by disc or arthritic spur, degenerative changes involvind main structures, disc protrusion, congenital abnormalities of the bony spinal column, infection, inflammation, neoplasm, vascular diseases." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001024 xsd:string

[Term]
id: HP:0011873
name: Abnormal Platelet Count
def: "Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood." []
xref: HP:0011873
is_a: HP:0001872 ! Abnormal Thrombocyte Morphology
property_value: SCDO:0000340 HP:0011873
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000617 xsd:string

[Term]
id: HP:0011886
name: Hyphema
def: "Bleeding in the anterior chamber of the eye." []
xref: HP:0011886
is_a: HP:0000478 ! Abnormality of the Eye
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011886 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000597 xsd:string

[Term]
id: HP:0011893
name: Abnormal Leukocyte Count
def: "Number of leukocytes per volume of blood beyond normal limits." []
synonym: "Abnormal White Blood Cell Count" EXACT []
xref: HP:0011893
is_a: SCDO:1000612 ! Abnormal Leukocyte Morphology
property_value: SCDO:0000340 HP:0011893
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000613 xsd:string

[Term]
id: HP:0011897
name: Neutrophilia
def: "Increased number of neutrophils circulating in blood." []
xref: HP:0011897
is_a: HP:0011991 ! Abnormal Neutrophil Count
property_value: SCDO:0000340 https://hpo.jax.org/app/browse/term/HP:0011897
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000447 xsd:string

[Term]
id: HP:0011904
name: Increased Hemoglobin F
def: "Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobiin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent." []
synonym: "Increased Haemoglobin F" EXACT []
synonym: "Persistence of Hemoglobin F" EXACT []
synonym: "Raised Hemoglobin F" EXACT []
xref: HP:0011904
is_a: HP:0020063 ! Increased Hemoglobin Concentration
is_a: SCDO:1000061 ! Altered Level of Normal Hemoglobin in SCD
relationship: SCDO:1000015 SCDO:0000251 ! modifies Clinical Phenotype of Beta Thalassemia
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011904 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000888 xsd:string

[Term]
id: HP:0011906
name: Reduced Beta/Alpha Synthesis Ratio
def: "A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia." []
synonym: "Increased Alpha/Beta Synthesis Ratio" EXACT []
xref: HP:0011906
is_a: HP:0005560 ! Imbalanced Hemoglobin Synthesis
relationship: SCDO:1000210 SCDO:0009731 ! has causal or contributing genetic variation Beta Thalassemia Mutation
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011906 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001709 xsd:string

[Term]
id: HP:0011907
name: Reduced Alpha/Beta Synthesis Ratio
def: "A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia." []
synonym: "Increased Beta/Alpha Synthesis Ratio" EXACT []
xref: HP:0011907
is_a: HP:0005560 ! Imbalanced Hemoglobin Synthesis
relationship: SCDO:1000210 SCDO:0001386 ! has causal or contributing genetic variation Alpha-Globin Locus Deletion
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011907 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006404 xsd:string

[Term]
id: HP:0011950
name: Bronchiolitis
def: "Inflammation of the bronchioles." []
xref: HP:0011950
is_a: HP:0002086 ! Abnormality of the Respiratory System
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011950 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005490 xsd:string

[Term]
id: HP:0011991
name: Abnormal Neutrophil Count
def: "A deviation from the normal range of neutrophil cell counts in the circulation." []
synonym: "Abnormal Neutrophil Cell Number" EXACT []
xref: HP:0011991
is_a: HP:0001874 ! Abnormality of Neutrophils
is_a: HP:0002715 ! Abnormality of the Immune System
property_value: SCDO:0000340 https://hpo.jax.org/app/browse/term/HP:0011991
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000446 xsd:string

[Term]
id: HP:0012100
name: Abnormal Circulating Creatinine Level
def: "An abnormal concentration of creatinine in the blood." []
synonym: "Abnormal Blood Creatinine Level" EXACT []
synonym: "Abnormal Serum Creatinine Level" EXACT []
synonym: "Creatinine Levels Abnormal" EXACT []
xref: HP:0012100
is_a: HP:0004364 ! Abnormal Circulating Nitrogen Compound Concentration
property_value: SCDO:0000340 HP:0012100
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000541 xsd:string

[Term]
id: HP:0012101
name: Decreased Serum Creatinine
def: "An abnormally reduced amount of creatinine in the blood." []
synonym: "Low Blood Creatinine" EXACT []
synonym: "Low Serum Creatinine" EXACT []
synonym: "Reduced Creatinine Levels" EXACT []
xref: HP:0012101
is_a: HP:0012100 ! Abnormal Circulating Creatinine Level
property_value: SCDO:0000340 HP:0012101
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000648 xsd:string

[Term]
id: HP:0012203
name: Onychomycosis
def: "A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split." []
comment: has disease stage: Distal lateral subungual onychomycosis (DLSO), White superficial onychomycosis (WSO), Proximal subungual onychomycosis (PSO),  Endonyx onychomycosis (EO), Candidal onychomycosis.\n\nIs characterised by: Disfigured nails, pain, paraesthesia, loss of dexterity, difficulty walking, standing, exercise.
xref: HP:0012203
is_a: NCIT:C3245 ! Fungal Infection
relationship: SCDO:0000664 IDO:0000560 ! treated with Antifungal
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: http://purl.org/dc/elements/1.1/source "Medscape: Onychomycosis:  Author: Antonella Tosti, MD; Chief Editor: Dirk M Elston, MD  et al.." xsd:string
property_value: SCDO:0000340 HP:0012203
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000831 xsd:string

[Term]
id: HP:0012229
name: Cerebrospinal Fluid Pleocytosis
def: "An increased white blood cell count in the cerebrospinal fluid." []
synonym: "CSF Pleocytosis" EXACT []
synonym: "Increased Leukocyte Count in CSF" EXACT []
xref: HP:0012229
is_a: HP:0002060 ! Abnormality of the Cerebrum
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0012229 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000212 xsd:string

[Term]
id: HP:0012243
name: Abnormal Reproductive System Morphology
def: "A structural or developmental anomaly of any of the tissues involved in the genital system." []
synonym: "Abnormal Genital System Morphology" EXACT []
xref: HP:0012243
is_a: HP:0000078 ! Abnormality of the Genital System
property_value: SCDO:0000340 HP:0012243
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009817 xsd:string

[Term]
id: HP:0012282
name: Morbilliform Rash
def: "An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days." []
comment: A morbilliform rash is said to resemble the rash of measles, rubella or scarlet fever, thus mimicking viral and bacterial exanthemas.
xref: HP:0012282
is_a: HP:0011122 ! Abnormality of Skin Physiology
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000340 HP:0012282
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000770 xsd:string

[Term]
id: HP:0012330
name: Pyelonephritis
def: "An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices." []
xref: HP:0012330
is_a: HP:0000123 ! Nephritis
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0012330 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005758 xsd:string

[Term]
id: HP:0012379
name: Abnormal Enzyme/Coenzyme Activity
def: "An altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme." []
xref: HP:0012379
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
property_value: SCDO:0000340 HP:0012379
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000665 xsd:string

[Term]
id: HP:0012418
name: Hypoxemia
def: "An abnormally low level of blood oxygen." []
synonym: "Decreased Partial Pressure of Oxygen" EXACT []
synonym: "Low Blood Oxygen Level" EXACT []
xref: HP:0012418
is_a: MP:0002329 ! Abnormal Blood Gas Level
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0012418 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000604 xsd:string

[Term]
id: HP:0012444
name: Atrophic Brain
def: "Partial or complete wasting (loss) of brain tissue that was once present." []
synonym: "Brain Atrophy" EXACT []
synonym: "Brain Degeneration" EXACT []
synonym: "Brain Wasting" EXACT []
xref: HP:0012444
is_a: HP:0012639 ! Abnormal Nervous System Morphology
property_value: SCDO:0000340 HP:0012444
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000089 xsd:string

[Term]
id: HP:0012465
name: Elevated Hepatic Iron Concentration
def: "An increased level of iron in liver tissues." []
comment: This abnormality can be measured by liver biopsy or by hepatic magnetic resonance imaging.\nEquivalents
synonym: "Increased Iron Concentration in Liver" EXACT []
synonym: "Increased Liver Iron Level" EXACT []
xref: HP:0012465
is_a: HP:0001392 ! Abnormality of the Liver
is_a: NCIT:C115224 ! Hepatic Complication
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0012465 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000425 xsd:string

[Term]
id: HP:0012532
name: Chronic Pain
def: "Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months." []
synonym: "Long-Lasting Pain" EXACT []
xref: HP:0012532
is_a: SCDO:0000851 ! Pain
is_a: SCDO:0001334 ! Chronic Phenotype
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 HP:0012532
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001415 xsd:string

[Term]
id: HP:0012574
name: Mesangial Hypercellularity
def: "Increased numbers of mesangial cells per glomerulus, defined as four or more nuclei in a peripheral mesangial segment." []
synonym: "Mesangial Proliferation" EXACT []
xref: HP:0012574
is_a: HP:0000077 ! Abnormality of the Kidney
property_value: SCDO:0000340 HP:0012574
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006481 xsd:string

[Term]
id: HP:0012587
name: Macroscopic Hematuria
def: "Hematuria that is visible upon inspection of the urine." []
synonym: "Bloody Urine" EXACT []
synonym: "Gross Hematuria" EXACT []
xref: HP:0012587
is_a: SCDO:0000508 ! Hematuria
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0012587 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008145 xsd:string

[Term]
id: HP:0012594
name: Low Level Albuminuria
def: "The presence of mildly increased concentrations of albumin in the urine (in adults, 30-150 mg per day)." []
comment: The criteria for clinically significant proteinuria have been changed from an albumin-creatinine ratio (ACR) of 30 mg/mmol or more to 3 mg/mmol or more. This is because there is evidence that the risk of adverse outcomes is a continuum and starts at an ACR well below 30 mg/mmol.
synonym: "Micro-albuminuria" EXACT []
synonym: "Microalbuminuria" EXACT []
synonym: "Mildly Increased Albuminuria" EXACT []
synonym: "Moderately Increased Albuminuria" EXACT []
xref: HP:0012594
is_a: SCDO:0000037 ! Albuminuria
relationship: SCDO:1000220 SCDO:0001209 ! diagnosed using measurement Urine Albumin Concentration
relationship: SCDO:1000220 SCDO:0001210 ! diagnosed using measurement Urine Albumin Excretion Rate
relationship: SCDO:1000220 SCDO:0001212 ! diagnosed using measurement Urine Albumin-Creatinine Ratio
property_value: http://purl.org/dc/elements/1.1/source "Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care; NICE Clinical Guidelines (July 2014)" xsd:string
property_value: SCDO:0000340 HP:0012594
property_value: SCDO:0000340 http://patient.info/doctor/microalbuminuria xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/141501
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000764 xsd:string

[Term]
id: HP:0012638
name: Abnormal Nervous System Physiology
def: "A functional anomaly of the nervous system." []
synonym: "Abnormality of Nervous System Physiology" EXACT []
xref: HP:0012638
is_a: HP:0000707 ! Abnormality of the Nervous System
property_value: SCDO:0000340 HP:0012638
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000765 xsd:string

[Term]
id: HP:0012639
name: Abnormal Nervous System Morphology
def: "A structural anomaly of the nervous system." []
synonym: "Abnormal Shape of Nervous System" EXACT []
synonym: "Abnormality of Nervous System Morphology" EXACT []
xref: HP:0012639
is_a: HP:0000707 ! Abnormality of the Nervous System
property_value: SCDO:0000340 HP:0012639
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000764 xsd:string

[Term]
id: HP:0012735
name: Cough
def: "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." []
xref: HP:0012735
is_a: HP:0002086 ! Abnormality of the Respiratory System
property_value: SCDO:0000340 HP:0012735
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004069 xsd:string

[Term]
id: HP:0012759
name: Neurodevelopmental Abnormality
def: "A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities. This term should be used to describe abnormalities with onset in the developmental period." []
xref: HP:0012759
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0012759 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000800 xsd:string

[Term]
id: HP:0012819
name: Myocarditis
def: "Inflammation of the myocardium." []
comment: Myocarditis can be caused by a variety of bacterial and viral infections. Enteroviruses, especially coxsackievirus B, are often associated with acute myocarditis. However, with the advent of genetic analysis, adenovirus and parvovirus B19 have also been found to be frequent causes of myocarditis. Exposure to drug treatment, physical stimuli such as radiation and heat, metabolic disorders, immune disorders, and pregnancy are also causes of myocarditis. Many cases of myocarditis are idiopathic. Myocarditis presents with non-specific symptoms including chest pain, dyspnoea, and palpitations, and thus often mimics more common disorders such as coronary artery disease. In some patients, cardiac MRI and endomyocardial biopsy can help identify myocarditis, predict risk of cardiovascular events, and guide treatment.
xref: HP:0012819
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
property_value: http://purl.org/dc/elements/1.1/source HP:0012819
property_value: SCDO:0000340 HP:0012819
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004203 xsd:string

[Term]
id: HP:0020054
name: Abnormal Erythrocyte Physiology
def: "Any functional abnormality of erythrocytes (red-blood cells)." []
xref: HP:0020054
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
property_value: SCDO:0000340 HP:0020054
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000286 xsd:string

[Term]
id: HP:0020058
name: Abnormal Red Blood Cell Count
def: "Any deviation from the normal number of red blood cells per volume in the circulation." []
synonym: "Abnormal RBC Count" EXACT []
xref: HP:0020058
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
property_value: SCDO:0000340 HP:0020058
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000608 xsd:string

[Term]
id: HP:0020059
name: Increased Red Blood Cell Count
def: "An abnormal elevation above the normal number of red blood cells per volume in the circulation." []
synonym: "Increased RBC Count" EXACT []
xref: HP:0020059
is_a: HP:0020058 ! Abnormal Red Blood Cell Count
property_value: SCDO:0000340 HP:0020059
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000610 xsd:string

[Term]
id: HP:0020060
name: Decreased Red Blood Cell Count
def: "An abnormal reduction below the normal number of red blood cells per volume in the circulation." []
synonym: "Decreased RBC Count" EXACT []
xref: HP:0020060
is_a: HP:0020058 ! Abnormal Red Blood Cell Count
property_value: SCDO:0000340 HP:0020060
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000609 xsd:string

[Term]
id: HP:0020061
name: Abnormal Hemoglobin Concentration
def: "Any deviation from the normal concentration of hemoglobin in the blood." []
xref: HP:0020061
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
is_a: SCDO:0009613 ! Protein Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "It might seem wrong to place this class here, but note that a change in hemoglobin concentration affects the size/volume and hence morphology of erythrocytes.\n\nPerhaps add sub-classes \"Increased hemoglobin concentration\" and \"Decreased hemoglobin concentration\" from HPO...their descriptions don't seem quite right though (should it not rather be \"in the erythrocytes\", not \"in the circulation\"?" xsd:string
property_value: SCDO:0000340 HP:0020061
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000186 xsd:string

[Term]
id: HP:0020062
name: Decreased Hemoglobin Concentration
def: "An abnormal reduction below normal hemoglobin concentration in the circulation." []
xref: HP:0020062
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: SCDO:0000340 HP:0020062
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000377 xsd:string

[Term]
id: HP:0020063
name: Increased Hemoglobin Concentration
def: "An abnormal elevation above normal hemoglobin concentration in the circulation." []
xref: HP:0020063
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: SCDO:0000340 HP:0020063
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000378 xsd:string

[Term]
id: HP:0025031
name: Abnormality of the Digestive System
def: "Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus." []
xref: HP:0025031
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0025031 xsd:string
property_value: SCDO:0000340 "Kaeda JS, Roper D, Srivastava P, et al. Severe hemolytic anemia associated with the homozygous state for an unstable hemoglobin variant (Hb Bushwick). Blood 1995; 86:1977." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000335 xsd:string

[Term]
id: HP:0025065
name: Abnormal Mean Corpuscular Volume
def: "A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters." []
synonym: "Abnormal Erythrocyte Volume" EXACT []
synonym: "Abnormal MCV" EXACT []
xref: HP:0025065
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
property_value: SCDO:0000340 HP:0025065
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000624 xsd:string

[Term]
id: HP:0025066
name: Decreased Mean Corpuscular Volume
def: "A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters)." []
synonym: "Decreased MCV" EXACT []
synonym: "Low MCV" EXACT []
synonym: "Microcytosis" EXACT []
synonym: "Reduced Erythrocyte Volume" EXACT []
xref: HP:0025066
is_a: HP:0025065 ! Abnormal Mean Corpuscular Volume
property_value: SCDO:0000340 HP:0025066
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000625 xsd:string

[Term]
id: HP:0025142
name: Constitutional Symptom
def: "A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual." []
synonym: "Systemic Symptom" EXACT []
xref: HP:0025142
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0025142
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000269 xsd:string

[Term]
id: HP:0025435
name: Increased Lactate Dehydrogenase Level
def: "An elevated level of the enzyme lactate dehydrogenase in serum." []
synonym: "High Lactate Dehydrogenase Level" EXACT []
xref: HP:0025435
is_a: HP:0045040 ! Abnormal Lactate Dehydrogenase Level
property_value: SCDO:0000340 HP:0025435
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000652 xsd:string

[Term]
id: HP:0025546
name: Abnormal Mean Corpuscular Hemoglobin Concentration
def: "Deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." []
synonym: "Abnormal MCHC" EXACT []
synonym: "Abnormal Mean Cell Haemoglobin Concentration" EXACT []
synonym: "Abnormal Mean Cell Hb Concentration" EXACT []
synonym: "Abnormal Mean Cell Hemoglobin Concentration" EXACT []
synonym: "Abnormal Mean Corpuscular Haemoglobin Concentration" EXACT []
synonym: "Abnormal Mean Corpuscular Hb Concentration" EXACT []
xref: HP:0025546
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
property_value: SCDO:0000340 MP:0005640
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000631 xsd:string

[Term]
id: HP:0025547
name: Decreased Mean Corpuscular Hemoglobin Concentration
def: "Less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." []
synonym: "Decreased MCHC" EXACT []
synonym: "Decreased Mean Corpuscular Haemoglobin Concentration" EXACT []
synonym: "Low MCHC" EXACT []
synonym: "Low Mean Corpuscular Haemoglobin Concentration" EXACT []
synonym: "Low Mean Corpuscular Hemoglobin Concentration" EXACT []
synonym: "Reduced Mean Corpuscular Haemoglobin Concentration" EXACT []
synonym: "Reduced Mean Corpuscular Hemoglobin Concentration" EXACT []
xref: HP:0025547
is_a: HP:0025546 ! Abnormal Mean Corpuscular Hemoglobin Concentration
property_value: SCDO:0000340 MP:0005642
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000635 xsd:string

[Term]
id: HP:0025548
name: Increased Mean Corpuscular Hemoglobin Concentration
def: "Greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices." []
synonym: "High MCHC" EXACT []
synonym: "High Mean Corpuscular Haemoglobin Concentration" EXACT []
synonym: "High Mean Corpuscular Hemoglobin Concentration" EXACT []
synonym: "Increased MCHC" EXACT []
synonym: "Increased Mean Corpuscular Haemoglobin Concentration" EXACT []
xref: HP:0025548
is_a: HP:0025546 ! Abnormal Mean Corpuscular Hemoglobin Concentration
property_value: SCDO:0000340 MP:0005641
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000636 xsd:string

[Term]
id: HP:0025636
name: Endometritis
def: "Inflammation of the inner lining of the uterus" []
def: "Local accumulation of fluid, plasma proteins, and leukocytes in the endometrium." []
synonym: "Endometrial Inflammation" EXACT []
synonym: "Endometrium Inflammation" EXACT []
xref: HP:0025636
is_a: HP:0000078 ! Abnormality of the Genital System
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MP_0009360 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000433 xsd:string

[Term]
id: HP:0030049
name: Brain Abscess
def: "A collection of pus, immune cells, and other material in the brain." []
comment: Brain abscess usually results from a bacterial or fungal infection.
xref: HP:0030049
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: HP:0012639 ! Abnormal Nervous System Morphology
relationship: SCDO:0000663 CMO:0000364 ! diagnosed using tool Complete Blood Count
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 SCDO:0000139 ! diagnosed using tool Blood Culture
relationship: SCDO:0000663 SCDO:0000217 ! diagnosed using tool Chest X-Ray
relationship: SCDO:0000663 SCDO:0000420 ! diagnosed using tool Electroencephalography
relationship: SCDO:0000663 SCDO:0000963 ! diagnosed using tool Radiography
relationship: SCDO:0000664 IDO:0000560 ! treated with Antifungal
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0030049 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000159 xsd:string

[Term]
id: HP:0030050
name: Narcolepsy
def: "An abnormal phenomenon characterized by a classic tetrad of excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination, and sleep paralysis." []
xref: HP:0030050
is_a: HP:0000708 ! Behavioural Abnormality
relationship: SCDO:0000663 OGMS:0000088 ! diagnosed using tool Patient Symptom Report
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
property_value: SCDO:0000303 HP:0030050
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000790 xsd:string

[Term]
id: HP:0030058
name: Sickled Erythrocyte
def: "An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains)." []
synonym: "Banana Cell" EXACT []
synonym: "Drepanocyte" EXACT []
synonym: "Sickle Cell" EXACT []
synonym: "Sickled Erythrocyte" EXACT []
synonym: "Sickled Red Blood Cell" EXACT []
xref: HP:0030058
is_a: HP:0004447 ! Poikilocytosis
property_value: SCDO:0000340 HP:0030058
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000246 xsd:string

[Term]
id: HP:0030127
name: Endometriosis
def: "The growth of endometrial tissue outside the uterus." []
xref: HP:0030127
is_a: HP:0012243 ! Abnormal Reproductive System Morphology
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0030127 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000432 xsd:string

[Term]
id: HP:0030243
name: Hepatic Vein Thrombosis
def: "An obstruction in the veins of the liver caused by a blood clot (thrombosis)." []
synonym: "Blood Clot in Liver Vein" EXACT SCDO:1000291 []
xref: HP:0030243
is_a: HP:0001977 ! Abnormal Thrombosis
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0030243 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001673 xsd:string

[Term]
id: HP:0030248
name: Mesenteric Venous Thrombosis
def: "A clot that obstructs blood flow in a mesenteric vein (the superior and the inferior mesenteric vein drain blood from the small and large intestine)." []
synonym: "Blood Clot in Mesenteric Vein" EXACT []
xref: HP:0030248
is_a: HP:0001977 ! Abnormal Thrombosis
property_value: SCDO:0000340 HP:0030248
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004437 xsd:string

[Term]
id: HP:0030680
name: Abnormal Cardiovascular System Morphology
def: "Any structural anomaly of the heart and great vessels." []
xref: HP:0030680
is_a: HP:0001626 ! Abnormality of Cardiovascular System
property_value: SCDO:0000340 HP:0030680
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000369 xsd:string

[Term]
id: HP:0031368
name: Intestinal Perforation
def: "A hole (perforation) in the wall of the intestine." []
xref: HP:0031368
is_a: SCDO:1000433 ! Intestinal Injury
property_value: SCDO:0000340 https://hpo.jax.org/app/browse/term/HP:0031368
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000434 xsd:string

[Term]
id: HP:0031456
name: Ectopic Pregnancy
def: "A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube)." []
xref: HP:0031456
is_a: NCIT:C34941 ! Pregnancy Complication
is_a: SCDO:1000371 ! Prenatal Maternal Abnormality
property_value: SCDO:0000340 HP:0031456
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000413 xsd:string

[Term]
id: HP:0031956
name: Elevated Serum Aspartate Aminotransferase
def: "An abnormally high concentration in the circulation of aspartate aminotransferase (AST)." []
synonym: "Aspartate Aminotransferase Increased" EXACT []
synonym: "Elevated Serum AST" EXACT []
synonym: "Elevated Serum Glutamic Oxaloacetic Transaminase" EXACT []
synonym: "Increased Aspartate Aminotransferase" EXACT []
xref: HP:0031956
is_a: HP:0012379 ! Abnormal Enzyme/Coenzyme Activity
property_value: SCDO:0000340 HP:0031956
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000661 xsd:string

[Term]
id: HP:0031964
name: Elevated Serum Alanine Aminotransferase
def: "An abnormally high concentration in the circulation of alanine aminotransferase (ALT), which is an enzyme that catalyzes the transfer of amino groups to form the hepatic metabolite oxaloacetate. ALT is found abundantly in the cytosol of the hepatocyte. ALT activity in the liver is about 3000 times that of serum activity. Thus, in the case of hepatocellular injury or death, release of ALT from damaged liver cells increases measured ALT activity in the serum. Although it is generally thought to be specific to the liver, it is also found in the kidney, and, in much smaller quantities, in heart and skeletal muscle cells." []
synonym: "Alanine Aminotransferase Increased" EXACT []
synonym: "Elevated serum ALT" EXACT []
synonym: "Elevated Serum Glutamic-Pyruvic Transaminase" EXACT []
xref: HP:0031964
is_a: HP:0012379 ! Abnormal Enzyme/Coenzyme Activity
property_value: SCDO:0000340 HP:0031964
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000659 xsd:string

[Term]
id: HP:0032180
name: Abnormal Circulating Metabolite Concentration
def: "An abnormal level of an analyte measured in the blood." []
xref: HP:0032180
is_a: MP:0009642 ! Abnormal Blood Homeostasis
property_value: SCDO:0000340 https://hpo.jax.org/app/browse/term/HP:0032180
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000437 xsd:string

[Term]
id: HP:0032224
name: ABO Blood Group
def: "The ABO histo-blood group consists of two antigens (A and B antigens) and four blood types (types A, B, AB, and O). The A and B antigens are the product of the ABO gene and are autosomal codominant. The group O phenotype is an autosomal-recessive phenotype due to the homozygous inheritance of two null ABO alleles. Group O individuals express the H antigen, the biosynthetic precursor to A and B antigens. ABO, therefore, is the blood type, whereas A, B, and H refer to the antigens. The ABO system consists of A and B antigens and antibodies against these antigens." []
xref: HP:0032224
is_a: SCDO:0009884 ! Biochemical Phenotype
property_value: SCDO:0000340 HP:0032224
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000581 xsd:string

[Term]
id: HP:0045040
name: Abnormal Lactate Dehydrogenase Level
def: "A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate." []
xref: HP:0045040
is_a: HP:0012379 ! Abnormal Enzyme/Coenzyme Activity
property_value: SCDO:0000340 HP:0045040
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000683 xsd:string

[Term]
id: HP:0045048
name: Increased Hemoglobin A2
def: "An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia." []
synonym: "Increased HbA2 Hemoglobin" EXACT []
xref: HP:0045048
is_a: HP:0020063 ! Increased Hemoglobin Concentration
is_a: SCDO:1000061 ! Altered Level of Normal Hemoglobin in SCD
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0045048 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000630 xsd:string

[Term]
id: HP:0100601
name: Eclampsia
def: "An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders." []
xref: HP:0100601
is_a: NCIT:C34941 ! Pregnancy Complication
is_a: SCDO:1000371 ! Prenatal Maternal Abnormality
relationship: SCDO:0000664 SCDO:0000067 ! treated with Antihypertensive Agents
relationship: SCDO:1000220 CMO:0000256 ! diagnosed using measurement Urine Measurement
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 HP:0100601
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000411 xsd:string

[Term]
id: HP:0100602
name: Preeclampsia
def: "Pregnancy-induced hypertension in association with significant amounts of protein in the urine." []
synonym: "Pre-Eclampsia" EXACT []
xref: HP:0100602
is_a: NCIT:C34941 ! Pregnancy Complication
is_a: SCDO:0000267 ! Comorbid Disease
is_a: SCDO:1000371 ! Prenatal Maternal Abnormality
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0100602 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000918 xsd:string

[Term]
id: HP:0100614
name: Myositis
def: "A general term for inflammation of the muscles without respect to the underlying cause." []
synonym: "Muscle Inflammation" EXACT []
xref: HP:0100614
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: SCDO:1000268 ! Abnormality of the Musculature
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0100614 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000785 xsd:string

[Term]
id: HP:0100749
name: Chest Pain
def: "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest." []
synonym: "Thoracic Pain" EXACT []
xref: HP:0100749
is_a: SCDO:0000851 ! Pain
property_value: SCDO:0000340 HP:0100749
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001988 xsd:string

[Term]
id: HP:0100774
name: Hyperostosis
def: "Excessive growth or abnormal thickening of bone tissue." []
synonym: "Bone Hypertrophy" EXACT []
synonym: "Bone Overgrowth" EXACT []
xref: HP:0100774
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0100774 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000591 xsd:string

[Term]
id: HP:0100806
name: Sepsis
def: "Severe systemic inflammatory response to infection." []
comment: caused by: Bacteria and fungus mainly\n\ncharacterised by: Systematic manifestations of inflammation\n\nhas disease stage: Mild, moderate, severe
xref: HP:0100806
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: IDO:0000586 ! Infection
relationship: SCDO:0000663 SCDO:0000139 ! diagnosed using tool Blood Culture
relationship: SCDO:0000664 IDO:0000560 ! treated with Antifungal
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Perhaps remove here and only keep below \"Abnormality of the Immune System\"?\nSource needed for additional information.\nPerhaps include different types of sepsis (see under D018805 in MESH)?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0100806 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001039 xsd:string

[Term]
id: HP:0100820
name: Glomerulopathy
def: "Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron." []
synonym: "Diseased Glomeruli" EXACT []
synonym: "Glomerulopathies" EXACT []
xref: HP:0100820
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0100820 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000459 xsd:string

[Term]
id: HP:0200042
name: Skin Ulcer
def: "A discontinuity of the skin exhibiting loss of the epidermis and often portions of the dermis and subcutaneous fat." []
synonym: "Open Skin Sore" EXACT []
synonym: "Skin Ulcers" EXACT []
xref: HP:0200042
is_a: HP:0011121 ! Abnormality of Skin Morphology
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Find source for additional info" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0200042 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001074 xsd:string

[Term]
id: HP:0500015
name: Abnormal Cardiac Test
def: "Abnormal test result of cardiovascular physiology." []
xref: HP:0500015
is_a: HP:0001626 ! Abnormality of Cardiovascular System
property_value: SCDO:0000340 HP:0500015
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000266 xsd:string

[Term]
id: HsapDv:0000000
name: Human Life Cycle Stage
def: "A spatiotemporal region encompassing some part of the life cycle of an organism." []
synonym: "Developmental Stage" EXACT []
xref: HsapDv:0000000
is_a: NCIT:C43646 ! Association
property_value: SCDO:0000303 "See specific stages in the \"Human Developmental Stages Ontology\"" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HsapDv_0000000 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007384 xsd:string

[Term]
id: ICO:0000036
name: Date of Signing Consent
def: "A date specification that designates when an informed consent form was signed." []
synonym: "Date Subject Signed Consent" EXACT []
synonym: "Informed Consent Form Signing Date" EXACT []
xref: ICO:0000036
is_a: SCDO:1000522 ! Temporal Observable of Consent
property_value: SCDO:0000340 ICO:0000036
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000531 xsd:string

[Term]
id: ICO:0000157
name: Parental Consent
def: "An informed consent by the parent/guardian of a child or a minor to consent to give permission for the child/minor to be included in research." []
synonym: "Parental Informed Consent Process" EXACT []
synonym: "Parental Permission" EXACT []
synonym: "Parental Permission Consent" EXACT []
xref: ICO:0000157
is_a: SCDO:0003712 ! Proxy Consent
is_a: SCDO:0007087 ! Informed Consent
property_value: SCDO:0000340 ICO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FICO:0000157
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009293 xsd:string

[Term]
id: ICO:0000179
name: Broad Consent
def: "An informed consent for an unspecified range of future research subject to a few content and/or process restrictions." []
xref: ICO:0000179
is_a: SCDO:0007087 ! Informed Consent
property_value: SCDO:0000340 ICO:0000179
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008115 xsd:string

[Term]
id: ICO:0000228
name: Data Sharing
def: "A planned process in which data possessed by one person or organization is shared with one or more other persons or organizations." []
synonym: "Act of Data Sharing" EXACT []
xref: ICO:0000228
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000340 ICO:0000228
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009586 xsd:string

[Term]
id: ICO:0000255
name: Participant Withdrawal Process
def: "A directive information entity that prescribes some process for withdraw from another planned process." []
synonym: "Withdrawal from Participation Directive" EXACT []
xref: ICO:0000255
is_a: SCDO:1000422 ! Basic Element of a Consent Form
property_value: SCDO:0000340 ICO:0000255
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000428 xsd:string

[Term]
id: ICO:0000278
name: Description of Future Biospecimen Use
def: "A descriptive information content entity that describes how biospecimens will be used." []
xref: ICO:0000278
is_a: ICO:0000305 ! Description of Future Use
property_value: SCDO:0000340 ICO:0000278
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000456 xsd:string

[Term]
id: ICO:0000293
name: Data Sharing Agreement
def: "A directive information entity that prescribes the information that is permitted to be shared or the processes for sharing that information." []
synonym: "Data Sharing Directive" EXACT []
xref: ICO:0000293
is_a: SCDO:1000406 ! Data Sharing Descriptor
property_value: SCDO:0000340 ICO:0000293
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000407 xsd:string

[Term]
id: ICO:0000304
name: Description of Future Data Use
def: "A descriptive information content entity that describes how data will be used." []
xref: ICO:0000304
is_a: ICO:0000305 ! Description of Future Use
property_value: SCDO:0000340 ICO:0000304
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000453 xsd:string

[Term]
id: ICO:0000305
name: Description of Future Use
def: "A descriptive information content entity that describes future use of material or information." []
xref: ICO:0000305
is_a: SCDO:1000422 ! Basic Element of a Consent Form
property_value: SCDO:0000340 ICO:0000305
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000454 xsd:string

[Term]
id: IDO:0000515
name: Microbiome
def: "An organism population whose members are particpating in non-parasitic symbiosis with a particular host." []
synonym: "Normal Resident Microbiota Population" EXACT []
synonym: "Normal Resident Microflora Population" EXACT []
xref: IDO:0000515
is_a: SCDO:0000122 ! Biological Disease Modifier
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/IDO_0000515 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000755 xsd:string

[Term]
id: IDO:0000560
name: Antifungal
def: "A material entity bearing an antifungal disposition." []
xref: IDO:0000560
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 HP:0000388 ! treats Otitis Media
relationship: SCDO:1000018 HP:0006689 ! treats Bacterial Endocarditis
relationship: SCDO:1000018 HP:0008404 ! treats Nail Dystrophy
relationship: SCDO:1000018 HP:0012203 ! treats Onychomycosis
relationship: SCDO:1000018 HP:0030049 ! treats Brain Abscess
relationship: SCDO:1000018 HP:0100806 ! treats Sepsis
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/IDO_0000560 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000019 xsd:string

[Term]
id: IDO:0000586
name: Infection
def: "A part of an extended organism that itself has as part a population of one or more infectious agents and that (1) exists as a result of processes initiated by members of the infectious agent population and is (2) clinically abnormal in virtue of the presence of this infectious agent population, or (3) has a disposition to bring clinical abnormality to immunocompetent organisms of the same Species as the host (the organism corresponding to the extended organism) through transmission of a member or offspring of a member of the infectious agent population." []
xref: IDO:0000586
is_a: DOID:4 ! Disease
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Perhaps use Bacterial Infection and Viral Infection as modifiers?\n\nInclude here \"transfusion-related hepatitis infections\" and or \"viral hepatitis\" (See paper \"Liver involvement in sickle cell disease\" by Emel GÜRKAN et al.)" xsd:string
property_value: SCDO:0000340 IDO:0000586
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000635 xsd:string

[Term]
id: IDOMAL:0000122
name: Malaria Chemoprophylaxis
def: "The use of antimalarial drugs for the prevention of infection." []
xref: IDOMAL:0000122
is_a: SCDO:0000709 ! Malaria Prophylaxis
property_value: SCDO:0000340 IDOMAL:0000122
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000668 xsd:string

[Term]
id: IDOMAL:0000592
name: Spleen Examination
def: "Any process carried out to determine the condition of a patient's spleen." []
xref: IDOMAL:0000592
is_a: SCDO:0000898 ! Physical Examination
property_value: SCDO:0000303 "Needs relating to Splenomegaly phenotype." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/IDOMAL_0000592 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001101 xsd:string

[Term]
id: IDOMAL:50000026
name: Mutation
def: "A permanent change in the DNA sequence of a gene that alters the genetic message carried by that gene." []
xref: IDOMAL:50000026
is_a: SCDO:0001369 ! Genetic Variation
relationship: SCDO:1000015 NCIT:C26548 ! modifies Gene Product
property_value: SCDO:0000303 "Perhaps include here an \"Alpha Thalassemia Mutation\" sub-class? Could use the current description for \"Alpha-Globin Locus Deletion\" and instead give \"Alpha-Globin Locus Deletion\" a description similar to that of \"Beta-Globin Locus Deletion\"" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/IDOMAL_50000026 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001370 xsd:string

[Term]
id: MP:0001212
name: Skin Lesions
def: "Focal pathological and/or inflammatory changes characterized by alteration in the size, shape and organization of the cellular components of the skin." []
xref: MP:0001212
is_a: HP:0011123 ! Skin Inflammation
property_value: SCDO:0000340 MP:0001212
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001072 xsd:string

[Term]
id: MP:0001589
name: Abnormal Mean Corpuscular Hemoglobin
def: "Anomalies in the average levels of hemoglobin contained in an erythrocyte." []
synonym: "Abnormal MCH" EXACT []
synonym: "Abnormal Mean Cell Hemoglobin" EXACT []
synonym: "Abnormal Mean Cell Hemoglobin Level" EXACT []
synonym: "Abnormal Mean Corpuscular Hemoglobin Level" EXACT []
xref: MP:0001589
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
property_value: SCDO:0000340 MP:0001589
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000632 xsd:string

[Term]
id: MP:0001762
name: Diuresis
def: "Increased volume of urine produced and excreted." []
comment: Clinicians sometimes mistakenly label increased urinary frequency as polyuria (increased urine output); Though rarely used, pollakisuria (or pollakiuria) is the correct term for increased frequency of urination.
synonym: "Increased Urine Output" EXACT []
synonym: "Increased Urine Volume" EXACT []
synonym: "Polyuria" EXACT []
xref: MP:0001762
is_a: HP:0000079 ! Abnormality of the Urinary System
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MP_0001762 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000395 xsd:string

[Term]
id: MP:0001792
name: Impaired Wound Healing
def: "Reduced ability or inability to self-repair and close wounds." []
synonym: "Delayed Wound Healing" EXACT []
synonym: "Impaired Wound Repair" EXACT []
xref: MP:0001792
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 MP:0001792
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000622 xsd:string

[Term]
id: MP:0002081
name: Perinatal Death
def: "Death anytime within the perinatal period." []
synonym: "Perinatal Lethality" EXACT []
xref: MP:0002081
is_a: HP:0001197 ! Abnormality of Prenatal Development or Birth
property_value: SCDO:0000340 MP:0002081
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000883 xsd:string

[Term]
id: MP:0002118
name: Abnormal Lipid Homeostasis
def: "Anomaly in the processes involved in the maintenance of an internal equilibrium of lipids in the fluids and tissues." []
xref: MP:0002118
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
property_value: SCDO:0000340 MP:0002118
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000284 xsd:string

[Term]
id: MP:0002329
name: Abnormal Blood Gas Level
def: "Anomaly in the amount of oxygen and carbon dioxide in the blood." []
xref: MP:0002329
is_a: HP:0002086 ! Abnormality of the Respiratory System
is_a: MP:0009642 ! Abnormal Blood Homeostasis
property_value: SCDO:0000340 MP:0002329
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000810 xsd:string

[Term]
id: MP:0002412
name: Increased Susceptibility to Bacterial Infection
def: "Greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria." []
comment: Characterised by: Repeated/recurrent local or systemic bacterial infections.\n\nCaused by: Multifactorial generally factors ultimately cause impaired immunity.
synonym: "Decreased Resistance to Bacterial infection" EXACT []
xref: MP:0002412
is_a: HP:0002715 ! Abnormality of the Immune System
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000930 ! treated with Infection Prophylaxis
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MP_0002412 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000632 xsd:string

[Term]
id: MP:0003224
name: Neuron Degeneration
def: "A retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses." []
synonym: "Nerve Degeneration" EXACT []
synonym: "Nerve Degenerations" EXACT []
synonym: "Neuron Degenerations" EXACT []
xref: MP:0003224
is_a: HP:0012639 ! Abnormal Nervous System Morphology
property_value: http://purl.org/dc/elements/1.1/source http://www.neurodegenerationresearch.eu/about/what/ xsd:string
property_value: SCDO:0000303 "Provide source for additional info." xsd:string
property_value: SCDO:0000340 MP:0003224
property_value: SCDO:0000468 "Usually in the elderly persons. Aging associated with most disorders" xsd:string
property_value: SCDO:0000661 "Multifactorial causes such as program cell death, genetic mutations, protein misfolding and intracellular mechanisms" xsd:string
property_value: SCDO:0000662 "Multiple disease entities such as alzhiemers disease, parkinsons disease , huntington's disease and amylotrophic lateral sclerosis" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000802 xsd:string

[Term]
id: MP:0005376
name: Metabolism/Homeostasis Phenotype
def: "The observable morphological and physiological characteristics related to a state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues or the processes that cause many of the chemical changes in living mammalian organisms that are manifested through development and lifespan." []
synonym: "Homeostasis Phenotype" EXACT []
synonym: "Homeostasis/Metabolism Phenotype" EXACT []
xref: MP:0005376
is_a: OGMS:0000023 ! Phenotype
property_value: SCDO:0000340 MP:0005376
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000811 xsd:string

[Term]
id: MP:0005533
name: Increased Body Temperature
def: "Greater than the level of heat natural to a living being." []
synonym: "Raised Body Temperature" EXACT []
xref: MP:0005533
is_a: MP:0005535 ! Abnormal Body Temperature
property_value: SCDO:0000340 MP:0005533
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000761 xsd:string

[Term]
id: MP:0005534
name: Decreased Body Temperature
def: "Less than the level of heat natural to a living being." []
synonym: "Reduced Body Temperature" EXACT []
xref: MP:0005534
is_a: MP:0005535 ! Abnormal Body Temperature
property_value: SCDO:0000340 MP:0005534
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000762 xsd:string

[Term]
id: MP:0005535
name: Abnormal Body Temperature
def: "Deviation in the level of heat natural to a living being." []
xref: MP:0005535
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
property_value: SCDO:0000340 MP:0005535
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000760 xsd:string

[Term]
id: MP:0005561
name: Increased Mean Corpuscular Hemoglobin
def: "Greater than the average levels of hemoglobin contained in an erythrocyte." []
synonym: "High MCH" EXACT []
synonym: "High Mean Corpuscular Hemoglobin" EXACT []
synonym: "Increased MCH" EXACT []
synonym: "Increased Mean Cell Hemoglobin" EXACT []
xref: MP:0005561
is_a: MP:0001589 ! Abnormal Mean Corpuscular Hemoglobin
property_value: SCDO:0000340 MP:0005561
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000634 xsd:string

[Term]
id: MP:0005562
name: Decreased Mean Corpuscular Hemoglobin
def: "Less than the average levels of hemoglobin contained in an erythrocyte." []
synonym: "Decreased MCH" EXACT []
synonym: "Decreased Mean Cell Hemoglobin" EXACT []
synonym: "Low MCH" EXACT []
synonym: "Low Mean Corpuscular Hemoglobin" EXACT []
xref: MP:0005562
is_a: MP:0001589 ! Abnormal Mean Corpuscular Hemoglobin
property_value: SCDO:0000340 MP:0005562
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000633 xsd:string

[Term]
id: MP:0009568
name: Abnormal Red Blood Cell Deformability
def: "A measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress." []
xref: MP:0009568
is_a: HP:0020054 ! Abnormal Erythrocyte Physiology
property_value: SCDO:0000340 MP:0009568
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000277 xsd:string

[Term]
id: MP:0009642
name: Abnormal Blood Homeostasis
def: "Anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood." []
synonym: "Abnormal Blood Chemistry" EXACT []
synonym: "Blood Chemistry Abnormalities" EXACT []
xref: MP:0009642
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
property_value: SCDO:0000340 MP:0009642
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000809 xsd:string

[Term]
id: MP:0010066
name: Abnormal Red Blood Cell Distribution Width
def: "An anomaly in the coefficient of variance (reference range) of the red blood cell volume for an organism." []
synonym: "Abnormal Erythrocyte Distribution Width" EXACT []
synonym: "Abnormal RDW" EXACT []
xref: MP:0010066
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
property_value: SCDO:0000340 MP:0010066
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000639 xsd:string

[Term]
id: MP:0010067
name: Increased Red Blood Cell Distribution Width
def: "Higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism." []
synonym: "High RCDW" EXACT []
synonym: "High RDW" EXACT []
synonym: "High Red Blood Cell Distribution Width" EXACT []
synonym: "Increased Erythrocyte Distribution Width" EXACT []
synonym: "Increased RCDW" EXACT []
synonym: "Increased RDW" EXACT []
xref: MP:0010067
is_a: MP:0010066 ! Abnormal Red Blood Cell Distribution Width
property_value: SCDO:0000340 MP:0010067
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000641 xsd:string

[Term]
id: MP:0010068
name: Decreased Red Blood Cell Distribution Width
def: "Lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism." []
synonym: "Decreased Erythrocyte Distribution Width" EXACT []
synonym: "Decreased RCDW" EXACT []
synonym: "Decreased RDW" EXACT []
synonym: "Low RCDW" EXACT []
synonym: "Low RDW" EXACT []
synonym: "Low Red Blood Cell Distribution Width" EXACT []
synonym: "Reduced RCDW" EXACT []
synonym: "Reduced RDW" EXACT []
synonym: "Reduced Red Blood Cell Distribution Width" EXACT []
xref: MP:0010068
is_a: MP:0010066 ! Abnormal Red Blood Cell Distribution Width
property_value: SCDO:0000340 MP:0010068
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000640 xsd:string

[Term]
id: MP:0010163
name: Hemolysis
def: "Destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity." []
synonym: "Erythrocytolysis" EXACT []
synonym: "Erythrolysis" EXACT []
synonym: "Haematolysis" EXACT []
synonym: "Haemolysis" EXACT []
synonym: "Hematolysis" EXACT []
synonym: "Hemolyses" EXACT []
xref: MP:0010163
is_a: HP:0020054 ! Abnormal Erythrocyte Physiology
property_value: SCDO:0000340 MP:0010163
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009017 xsd:string

[Term]
id: MP:0011468
name: Abnormal Urine Amino Acid Level
def: "Any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group." []
xref: MP:0011468
is_a: HP:0003110 ! Abnormal Urine Homeostasis
property_value: SCDO:0000340 MP:0011468
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000653 xsd:string

[Term]
id: MP:0011469
name: Abnormal Urine Creatinine Level
def: "Any change in the amount of creatinine in the urine" []
xref: MP:0011469
is_a: MP:0011468 ! Abnormal Urine Amino Acid Level
property_value: SCDO:0000340 MP:0011469
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000654 xsd:string

[Term]
id: MP:0011470
name: Increased Urine Creatinine Level
def: "An increased amount of creatinine in the urine compared to the normal state." []
xref: MP:0011470
is_a: MP:0011469 ! Abnormal Urine Creatinine Level
property_value: SCDO:0000340 MP:0011470
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000656 xsd:string

[Term]
id: MP:0011471
name: Decreased Urine Creatinine Level
def: "a reduced amount of creatinine in the urine compared to the normal state" []
synonym: "Low Urine Creatinine Level" EXACT []
synonym: "Reduced Urine Creatinine Level" EXACT []
xref: MP:0011471
is_a: MP:0011469 ! Abnormal Urine Creatinine Level
property_value: SCDO:0000340 MP:0011471
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000655 xsd:string

[Term]
id: MP:0013305
name: Isosthenuria
def: "Inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake." []
comment: Urine specific gravity is similar to that of plasma (1.008-1.012).
synonym: "Impaired Urine-Concentrating Ability" EXACT []
synonym: "Urine Concentrating Defect" EXACT []
xref: MP:0013305
is_a: HP:0004727 ! Impaired Renal Concentrating Ability
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MP_0013305 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000667 xsd:string

[Term]
id: NBO:0000131
name: Alcohol Intake
def: "A drinking behavior associated with the intake of alcohol." []
synonym: "Alcohol Consumption" EXACT []
xref: NBO:0000131
is_a: SCDO:0000487 ! Health Behaviour
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NBO_0000131 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000039 xsd:string

[Term]
id: NCIT:65495
name: Duloxetine
def: "A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes." []
synonym: "Cymbalta" EXACT []
synonym: "Duloxetine HCl" EXACT []
synonym: "N-methyl-3-(1-naphthalenyloxy)-3-(2-thiophene)propanamide" EXACT []
xref: NCIT:65495
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/D000068736
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C65495 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006467 xsd:string

[Term]
id: NCIT:C101217
name: Retinal Examination
def: "An examination of the retina of the eye using an ophthalmoscope." []
synonym: "Fundoscopy" EXACT []
xref: NCIT:C101217
is_a: SCDO:0000835 ! Ophthalmoscopy
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C101217 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001009 xsd:string

[Term]
id: NCIT:C102531
name: Pulmonary Infiltrate
def: "A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma." []
synonym: "Lung Infiltrate" EXACT []
xref: NCIT:C102531
is_a: HP:0002086 ! Abnormality of the Respiratory System
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C102531
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007383 xsd:string

[Term]
id: NCIT:C102988
name: Patient Reported Outcomes Measurement Information System (PROMIS)
def: "A project to develop standards for the collection and analysis of patient-reported health status data using a system of highly reliable, precise measures for physical, mental, and social well-being. Patients are asked a series of rigorously reviewed questions covering common domains and metrics across differing conditions and treatments. The questions can be administered in short forms or adaptively through computerized adaptive testing and reports can be generated to allow clinicians to better understand how treatments might affect the quality of life of their patients." []
synonym: "Patient Reported Outcomes Measurement Information System" EXACT []
synonym: "PROMIS" EXACT []
xref: NCIT:C102988
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/source "Bevans, M., Ross, A., & Cella, D. (2014). Patient-Reported Outcomes Measurement Information System (PROMIS): Efficient, standardized tools to measure self-reported health and quality of life. Nursing Outlook, 62, 339-345." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Dampier C, Barry V, Gross HE, Lui Y, Thornburg CD, DeWalt DA, Reeve BB. (2016). Initial Evaluation of the Pediatric PROMIS® Health Domains in Children and Adolescents With Sickle Cell Disease. Pediatric Blood & Cancer. Feb 19. doi: 10.1002/pbc.25944." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "DeWitt, E. M., Barnett, K., Farrell, J., Revicki, D., Carle, A., Cook, K., Sherry, D. D. (2014). A164: Development of pediatric item banks to measure pain behavior in the Patient-Reported Outcomes Measurement Information System. Arthritis & Rheumatology, 66(Suppl. 11), S212-S2121." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C102988
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000871 xsd:string

[Term]
id: NCIT:C103165
name: Subject Visit Type
def: "The kind of visit undertaken by the subject within a study, such as inpatient, outpatient, telephone, etc." []
xref: NCIT:C103165
is_a: EUPATH:0000310 ! Information on Observation Details
property_value: SCDO:0000340 "C103165"
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000852 xsd:string

[Term]
id: NCIT:C103270
name: Waiver of Consent
def: "The release from the requirement to obtain informed consent during a study that is granted by Human Subject Protection committee for a research institution for a protocol that is being reviewed by the Institutional Review Board." []
comment: Waiver of the requirement of a signed consent form from potential participants or parents of children who are potential participants may be approved by a Research Ethics Committee if the research carries no more than minimal risk (i.e., risk that is no more likely and not greater than that attached to routine medical or psychological examination) and if the procedures to be used are only those for which signed consent forms are not customarily required outside the research context. Such waivers may also be approved when existence of a signed consent form would be an unjustified threat to the participant's confidentiality.
synonym: "Consent Waiver" EXACT []
synonym: "Waiver Of Informed Consent" EXACT []
xref: NCIT:C103270
is_a: SCDO:1000462 ! Research Ethics Committee Decision
property_value: http://purl.org/dc/elements/1.1/source "International Ethical Guidelines for Health-related Research Involving Humans, Fourth Edition. Geneva. Council for International Organizations of Medical Sciences (CIOMS); 2016." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C103270
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005773 xsd:string

[Term]
id: NCIT:C103526
name: Patient Health Questionnaire-9 (PHQ-9)
def: "A 9-item scale using each of the 9 DSM-IV criteria with self-reported frequency of \"0\" (not at all) to \"3\" (nearly every day). One of the most widely used instruments to assess depression, PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression, respectively." []
synonym: "Patient Health Questionnaire - 9 Item" EXACT []
synonym: "Patient Health Questionnaire-9" EXACT []
synonym: "PHQ-9" EXACT []
synonym: "PHQ01" EXACT []
xref: NCIT:C103526
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/source "Kroenke K, Spitzer R, Williams W. The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine. 2001; 16: 606-616." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C103526
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000870 xsd:string

[Term]
id: NCIT:C107564
name: S-Nitroso-Hemoglobin
def: "Hemoglobin that has a nitric oxide bound to the cysteine at position 93 in the beta-globin chain." []
synonym: "S-Nitrosated Hemoglobin" EXACT []
synonym: "S-Nitrosohemoglobin" EXACT []
xref: NCIT:C107564
is_a: NCIT:C16676 ! Hemoglobin
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C107564
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000169 xsd:string

[Term]
id: NCIT:C113340
name: Secondary Amenorrhea
def: "The cessation of menstruation for six months or more in a female that is not pregnant, breastfeeding or menopausal." []
xref: NCIT:C113340
is_a: HP:0000080 ! Abnormality of Reproductive System Physiology
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C113340
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001447 xsd:string

[Term]
id: NCIT:C114300
name: Carboxyhemoglobin
def: "Hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO). This complex is produced after CO has been inhaled or as a byproduct of hemoglobin, protoporphyrin or dichloromethane catabolism. The heme-CO complex is approximately 200 times more stable than heme-oxygen complexes. Thus, high levels of carboxyhemoglobin in the circulation can lead to tissue hypoxia and death." []
synonym: "COHb" EXACT [] {synonymtypedef="abbreviation"}
xref: NCIT:C114300
is_a: NCIT:C16676 ! Hemoglobin
property_value: SCDO:0000340 NCIT:C114300
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000168 xsd:string

[Term]
id: NCIT:C114714
name: Dialysis Membrane Reaction
def: "A severe hypersensitivity-like reaction occurring during dialysis due to exposure to the dialysis membrane." []
synonym: "Dialyzer Reaction" EXACT []
xref: NCIT:C114714
is_a: NCIT:C78254 ! Device Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C114714
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000387 xsd:string

[Term]
id: NCIT:C114717
name: Dialysis Catheter Fracture
def: "A crack or break in a dialysis catheter caused by material weakness or mechanical compression." []
xref: NCIT:C114717
is_a: NCIT:C78254 ! Device Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C114717
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000386 xsd:string

[Term]
id: NCIT:C115199
name: Cardiovascular Complication
def: "Any heart or vascular disorder occurring as a consequence of injury to the cardiovascular system." []
xref: NCIT:C115199
is_a: NCIT:C2959 ! Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C115199
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000390 xsd:string

[Term]
id: NCIT:C115224
name: Hepatic Complication
def: "Any disorder of the liver occurring as a consequence of injury to the liver parenchyma." []
synonym: "Liver Complication" EXACT []
xref: NCIT:C115224
is_a: NCIT:C2959 ! Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C115224
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000382 xsd:string

[Term]
id: NCIT:C115319
name: Ophthalmologic Complication
def: "Any eye disorder occurring as a consequence of injury to the eye." []
synonym: "Ophthalmologic Manifestations" EXACT []
xref: NCIT:C115319
is_a: NCIT:C2959 ! Complication
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C115319
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000832 xsd:string

[Term]
id: NCIT:C116081
name: Dialysis Access Complication
def: "Any issue that arises as a consequence of a problem with a patient's dialysis access." []
xref: NCIT:C116081
is_a: NCIT:C2959 ! Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C116081
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000391 xsd:string

[Term]
id: NCIT:C116161
name: Multiplex Ligation-Dependent Probe Amplification
def: "A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a single pair of PCR primers. It is frequently used in the detection of genetic aberrations in tumors, and can distinguish sequences differing in only a single nucleotide." []
synonym: "MLPA" EXACT []
xref: NCIT:C116161
is_a: SCDO:0000913 ! Polymerase Chain Reaction
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C116161
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003929 xsd:string

[Term]
id: NCIT:C116942
name: Developmental Delay
def: "Failure to meet, or late achievement of developmental milestones." []
xref: NCIT:C116942
is_a: HP:0012759 ! Neurodevelopmental Abnormality
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source http://www.med.umich.edu/yourchild/topics/devdel.htm xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C116942
property_value: SCDO:0000661 "Can have many different causes, such as genetic causes (like Down syndrome), or complications of pregnancy and birth (like prematurity or infections). Often, however, the specific cause is unknown. Some causes can be easily reversed if caught early enough, such as hearing loss from chronic ear infections, or lead poisoning." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001293 xsd:string

[Term]
id: NCIT:C118385
name: deprecated-Avascular Necrosis
def: "Tissue death resulting from an interruption to the blood supply." []
synonym: "AVN" EXACT []
xref: NCIT:C118385
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "This is a synonym for osteonecrosis in our ontology (SCDO:0000841), which is controversial between different literature. Please check with a clinician if these two terms refer to the same condition." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C118385 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004832 xsd:string
is_obsolete: true
replaced_by: SCDO:0000841

[Term]
id: NCIT:C120254
name: Intelligence Scale - 16 to 90 years
def: "A standardized tool designed to assess an individual's cognitive abilities. It consists of a battery of tests that allow an investigator to conduct a comprehensive cognitive evaluation of IQ." []
synonym: "WAIS-IV" EXACT []
synonym: "Wechsler Adult Intelligence Scale - Fourth Edition" EXACT []
synonym: "Wechsler Adult Intelligence Scale 4th Edition" EXACT []
synonym: "Wechsler Adult Intelligence Scale, Fourth Edition" EXACT []
synonym: "Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV)" EXACT []
xref: NCIT:C120254
is_a: NCIT:C122920 ! Intelligence Scale
property_value: SCDO:0000303 "Life stage: Adolescent, Adult" xsd:string
property_value: SCDO:0000303 "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the WAIS-IV and the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V). The Working Group recommends providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for the WAIS-IV and the WISC-V for guidance on selecting an age-appropriate test for individuals." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820501 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Intelligence Scale - 16 to 90 years #820501" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000646 xsd:string

[Term]
id: NCIT:C120255
name: Intelligence Scale - 6 to 16 years 11 months
def: "A battery of tests that allow an investigator to conduct a comprehensive evaluation of a child or adolescent's cognitive ability." []
synonym: "Wechsler Intelligence Scale for Children-Fifth Edition" EXACT []
synonym: "Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V)" EXACT []
synonym: "WISC-V" EXACT []
xref: NCIT:C120255
is_a: NCIT:C122920 ! Intelligence Scale
property_value: SCDO:0000303 "It consists of a core battery of subtests, which focus on five specific domains (verbal comprehension, processing speed, visual spatial, working memory, and fluid reasoning), as well as optional ancillary subtests. These ancillary subtests measure areas that are important to areas of academic achievement." xsd:string
property_value: SCDO:0000303 "Life stage: Child, Adolescent" xsd:string
property_value: SCDO:0000303 "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the Wechsler Intelligence Scale for Children®-Fifth Edition (WISC-V) and Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI-IV), as well as between the WISC-V and the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV). The Working Group recommends that providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for WISC-V, WPPSI-IV, and WAIS-IV for guidance on selecting an age-appropriate test." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820503 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Intelligence Scale - 6 to 16 years 11 months #820503" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000648 xsd:string

[Term]
id: NCIT:C120256
name: Intelligence Scale - 2 years, 6 months to 7 years, 7 months
def: "A standardized tool designed to assess the cognitive development in preschool and young children (up to age 7 years and 7 months). It consists of a battery of tests that allow an investigator to conduct a comprehensive evaluation of IQ." []
synonym: "Wechsler Preschool & Primary Scale of Intelligence 4th Edition" EXACT []
synonym: "Wechsler Preschool and Primary Scale of Intelligenc-Fourth Edition" EXACT []
synonym: "Wechsler Preschool and Primary Scale of Intelligenc-Fourth Edition (WPPSI-IV)" EXACT []
synonym: "Wechsler Preschool and Primary Scale of Intelligence IV" EXACT []
synonym: "WPPSI-IV" EXACT []
xref: NCIT:C120256
is_a: NCIT:C122920 ! Intelligence Scale
property_value: SCDO:0000303 "Life stage: Toddler, Child" xsd:string
property_value: SCDO:0000303 "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the WPPSI-IV and the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) and between the WPPSI-IV and the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V). The Working Group recommends that providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for the WPPSI-IV, Bayley-III, and the WISC-V for guidance on selecting an age-appropriate test." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820502 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Intelligence Scale - 2 years, 6 months to 7 years, 7 months #820502" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000647 xsd:string

[Term]
id: NCIT:C122920
name: Intelligence Scale
def: "An assessment tool designed to measure an individual's cognitive capabilities. It may be general or it may assess abilities in more discrete cognitive domains." []
synonym: "Intelligence Test" EXACT []
xref: NCIT:C122920
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C122920
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000645 xsd:string

[Term]
id: NCIT:C122931
name: Imaging Transcranial Doppler Ultrasonography
def: "A diagnostic technique that uses pulsed Doppler ultrasound to both identify blood vessels in the brain and measure the velocity of blood flow through those vessels. It allows a more accurate estimation of stroke risk because it allows outlining of parenchymal structures and visualization of the examined vessels." []
synonym: "TCDi" EXACT []
xref: NCIT:C122931
is_a: NCIT:C154865 ! Cerebral Blood Flow Assay
is_a: NCIT:C17230 ! Ultrasound Test
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C122931 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000613 xsd:string

[Term]
id: NCIT:C123446
name: Continuous Ambulatory ECG
def: "A continuous electrocardiographic (ECG) recording that utilizes one or more leads that both records and stores data directly to a device worn by the subject, such that the subject need not be restricted to a medical facility, and may be able to participate in their customary activities of daily living." []
xref: NCIT:C123446
is_a: SCDO:0000500 ! Heart Function Test
relationship: SCDO:1000192 SCDO:0000416 ! uses diagnostic device Electrocardiographic Monitor
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C123446 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000281 xsd:string

[Term]
id: NCIT:C123667
name: Global Mental Status Screener - Adult
def: "A standardized rating scale developed by Ziad Nasreddine in 1996 to screen for mild cognitive dysfunction and impairment. This instrument assesses the following cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation" []
synonym: "MOCA" EXACT []
synonym: "MOCA01" EXACT []
synonym: "Montreal Cognitive Assessment" EXACT []
synonym: "Montreal Cognitive Assessment Functional Test" EXACT []
synonym: "Montreal Cognitive Assessment Questionnaire" EXACT []
xref: NCIT:C123667
is_a: SCDO:0000455 ! Global Mental Status Screener
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/130701
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C123667
property_value: SCDO:0000479 "PhenX protocol: Global Mental Status Screener - Adult #130701" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000335 xsd:string

[Term]
id: NCIT:C124059
name: Pulmonary Consolidation
def: "A chest X-ray finding indicating the presence of a radio-opaque area in the lung. The opacification is caused by fluid or solid material within the airways or lung parenchyma." []
synonym: "Air Space Opacificatio" EXACT []
synonym: "Air-Space Shadowing" EXACT []
synonym: "Airspace Consolidation" EXACT []
synonym: "Airspace Opacification" EXACT []
synonym: "Consolidation" EXACT []
xref: NCIT:C124059
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Described in the Tanzania guidelines as 'reduced air entry, increased tactile vocal fremitus, and dull percussion at lung bases, usually bilateral'." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C124059 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006222 xsd:string

[Term]
id: NCIT:C124065
name: Hepatic Iron Concentration
def: "A measurement of the concentration of iron in the liver as an estimate of body iron load." []
synonym: "Hepatic Iron" EXACT []
synonym: "Liver Iron" EXACT []
synonym: "Liver Iron Concentration" EXACT []
xref: NCIT:C124065
is_a: SCDO:0000728 ! Diagnostic Measurement
relationship: SCDO:1000190 NCIT:C16809 ! obtained via diagnostic tool Magnetic Resonance Imaging
relationship: SCDO:1000190 NCIT:C51677 ! obtained via diagnostic tool Liver Biopsy
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C124065 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000555 xsd:string

[Term]
id: NCIT:C124475
name: Mid Upper Arm Circumference
def: "A circumferential measurement of the largest part of the upper arm." []
synonym: "Mid-Upper Arm Circumference" EXACT []
synonym: "MUAC" EXACT []
synonym: "MUARMCIR" EXACT []
xref: NCIT:C124475
is_a: CMO:0000021 ! Body Morphological Measurement
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C124475 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000758 xsd:string

[Term]
id: NCIT:C126120
name: Oxygenated Hemoglobin
def: "Hemoglobin where the heme group has formed a reversible complex with oxygen (O2) in the lungs. This molecule is found in the systemic arteries and transports O2 from the lungs to the tissues where it is readily released." []
synonym: "HbO2" EXACT []
synonym: "Oxyhemoglobin" EXACT []
xref: NCIT:C126120
is_a: NCIT:C16676 ! Hemoglobin
property_value: SCDO:0000340 NCIT:C126120
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000275 xsd:string

[Term]
id: NCIT:C126121
name: Deoxygenated Hemoglobin
def: "Hemoglobin containing a heme group that is not bound to oxygen (O2). This molecule is normally found in the systemic veins following transit through capillaries and release of O2 into the tissues. Excess deoxyhemoglobin can be associated with hypoxia." []
synonym: "Deoxyhemoglobin" EXACT []
xref: NCIT:C126121
is_a: NCIT:C16676 ! Hemoglobin
property_value: SCDO:0000340 NCIT:C126121
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000057 xsd:string

[Term]
id: NCIT:C128326
name: Intra-Abdominal Abscess
def: "An abscess within the abdomen." []
xref: NCIT:C128326
is_a: IDO:0000586 ! Infection
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C128326 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008079 xsd:string

[Term]
id: NCIT:C129072
name: Hereditary Persistence of Fetal Hemoglobin
def: "The persistence of substantial fetal hemoglobin production into adulthood, usually associated with hemoglobinopathies due to mutations in the alpha and/or beta chain of hemoglobin." []
comment: This is a benign condition.
synonym: "Hereditary Persistence of Foetal Haemoglobin" EXACT []
synonym: "HPFH" EXACT []
xref: NCIT:C129072
is_a: SCDO:0007192 ! Quantitative Hemoglobinopathy
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:1000172 SCDO:1000235 ! has causal genotype Hereditary Persistence of Fetal Hemoglobin Genotype
relationship: SCDO:1000210 SCDO:0006860 ! has causal or contributing genetic variation HBG1 and/or HBG2 Mutations
relationship: SCDO:1000210 SCDO:1000063 ! has causal or contributing genetic variation HBB, 106-KB DEL
relationship: SCDO:1000218 NCIT:C35447 ! has manifestation Osteonecrosis of the Femoral Head
relationship: SCDO:1000223 HP:0011904 ! has causal molecular phenotype Increased Hemoglobin F
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C129072
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000560 xsd:string

[Term]
id: NCIT:C131682
name: Sickle Cell Disease-SS
def: "A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles." []
synonym: "Hb SS Disease" EXACT []
synonym: "Hb SS-Disease" EXACT []
synonym: "Hemoglobin SS Disease" EXACT []
synonym: "Homozygous Sickle Cell Disease" EXACT []
synonym: "SCA" EXACT []
synonym: "Severe SCD" EXACT []
synonym: "Sickle Cell Anemia" EXACT []
synonym: "Sickle Cell Disease SS" EXACT []
synonym: "Sickle Cell Hemoglobin S Disease" EXACT []
synonym: "Sickle Cell-SS Disease" EXACT []
synonym: "SS and S/Beta-Zero Thalassemia" EXACT []
xref: NCIT:C131682
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000106 ! Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0001364 SCDO:1000242 ! has mode of inheritance Autosomal Recessive Homozygous
relationship: SCDO:1000172 SCDO:1000053 ! has causal genotype Hemoglobin Genotype SS
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000218 ARO:0000006 ! has manifestation Erythromycin
relationship: SCDO:1000218 DOID:0060181 ! has manifestation Ischemic Cholitis
relationship: SCDO:1000218 DOID:2326 ! has manifestation Gastroenteritis
relationship: SCDO:1000218 DOID:813 ! has manifestation Septic Arthritis
relationship: SCDO:1000218 HP:0000084 ! has manifestation Kidney Failure
relationship: SCDO:1000218 HP:0000097 ! has manifestation Focal Segmental Glomerulosclerosis
relationship: SCDO:1000218 HP:0000822 ! has manifestation Hypertension
relationship: SCDO:1000218 HP:0000823 ! has manifestation Delayed Puberty
relationship: SCDO:1000218 HP:0001081 ! has manifestation Cholelithiasis
relationship: SCDO:1000218 HP:0001269 ! has manifestation Hemiparesis
relationship: SCDO:1000218 HP:0001394 ! has manifestation Cirrhosis
relationship: SCDO:1000218 HP:0001406 ! has manifestation Intrahepatic Cholestasis
relationship: SCDO:1000218 HP:0001635 ! has manifestation Cardiac Failure
relationship: SCDO:1000218 HP:0001658 ! has manifestation Myocardial Infarction
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000218 HP:0001873 ! has manifestation Thrombocytopenia
relationship: SCDO:1000218 HP:0001875 ! has manifestation Neutropenia
relationship: SCDO:1000218 HP:0001878 ! has manifestation Hemolytic Anemia
relationship: SCDO:1000218 HP:0001889 ! has manifestation Megaloblastic Anemia
relationship: SCDO:1000218 HP:0001896 ! has manifestation Reticulocytopenia
relationship: SCDO:1000218 HP:0001903 ! has manifestation Anemia
relationship: SCDO:1000218 HP:0001974 ! has manifestation Leukocytosis
relationship: SCDO:1000218 HP:0002090 ! has manifestation Pneumonia
relationship: SCDO:1000218 HP:0002204 ! has manifestation Pulmonary Embolism
relationship: SCDO:1000218 HP:0002240 ! has manifestation Hepatomegaly
relationship: SCDO:1000218 HP:0003158 ! has manifestation Hyposthenuria
relationship: SCDO:1000218 HP:0003265 ! has manifestation Neonatal Hyperbilirubinemia
relationship: SCDO:1000218 HP:0004756 ! has manifestation Ventricular Tachycardia
relationship: SCDO:1000218 HP:0004870 ! has manifestation Chronic Hemolytic Anemia
relationship: SCDO:1000218 HP:0011106 ! has manifestation Hypovolemia
relationship: SCDO:1000218 HP:0011950 ! has manifestation Bronchiolitis
relationship: SCDO:1000218 HP:0012330 ! has manifestation Pyelonephritis
relationship: SCDO:1000218 HP:0012532 ! has manifestation Chronic Pain
relationship: SCDO:1000218 HP:0012574 ! has manifestation Mesangial Hypercellularity
relationship: SCDO:1000218 HP:0012735 ! has manifestation Cough
relationship: SCDO:1000218 HP:0030243 ! has manifestation Hepatic Vein Thrombosis
relationship: SCDO:1000218 HP:0100749 ! has manifestation Chest Pain
relationship: SCDO:1000218 NCIT:C102531 ! has manifestation Pulmonary Infiltrate
relationship: SCDO:1000218 NCIT:C124059 ! has manifestation Pulmonary Consolidation
relationship: SCDO:1000218 NCIT:C128326 ! has manifestation Intra-Abdominal Abscess
relationship: SCDO:1000218 NCIT:C27088 ! has manifestation Hyperbilirubinemia
relationship: SCDO:1000218 NCIT:C28516 ! has manifestation Sickle Cell Dactylitis
relationship: SCDO:1000218 NCIT:C34465 ! has manifestation Cholecystitis
relationship: SCDO:1000218 NCIT:C35146 ! has manifestation Chronic Cholecystitis
relationship: SCDO:1000218 NCIT:C35152 ! has manifestation Acute Cholecystitis
relationship: SCDO:1000218 NCIT:C35372 ! has manifestation Ascending Cholangitis
relationship: SCDO:1000218 NCIT:C35447 ! has manifestation Osteonecrosis of the Femoral Head
relationship: SCDO:1000218 NCIT:C50791 ! has manifestation Urinary Tract Infection
relationship: SCDO:1000218 NCIT:C78598 ! has manifestation Posterior Reversible Leukoencephalopathy
relationship: SCDO:1000218 NCIT:C95437 ! has manifestation Acute Pancreatitis
relationship: SCDO:1000218 NCIT:C96239 ! has manifestation Glomerular Hypertrophy
relationship: SCDO:1000218 NCIT:C99042 ! has manifestation Renal Vein Thrombosis
relationship: SCDO:1000218 NCIT:C99063 ! has manifestation Spinal Cord Infarction
relationship: SCDO:1000218 SCDO:0000228 ! has manifestation Chronic Neuropathic Pain
relationship: SCDO:1000218 SCDO:0000508 ! has manifestation Hematuria
relationship: SCDO:1000218 SCDO:0000685 ! has manifestation Leg Ulcer
relationship: SCDO:1000218 SCDO:0000851 ! has manifestation Pain
relationship: SCDO:1000218 SCDO:0000943 ! has manifestation Pulmonary Hypertension
relationship: SCDO:1000218 SCDO:0001067 ! has manifestation Sickle Retinopathy
relationship: SCDO:1000218 SCDO:0001135 ! has manifestation Acute Sickle Cell Crisis
relationship: SCDO:1000218 SCDO:0001229 ! has manifestation Vaso-Occlusive Crisis
relationship: SCDO:1000218 SCDO:0001511 ! has manifestation Renal Medullary Carcinoma
relationship: SCDO:1000218 SCDO:0002039 ! has manifestation Zinc Deficiency
relationship: SCDO:1000218 SCDO:0002106 ! has manifestation Splenic Infarction
relationship: SCDO:1000218 SCDO:0004187 ! has manifestation Hemolytic Crisis
relationship: SCDO:1000218 SCDO:0004576 ! has manifestation Chronic Hypersplenism
relationship: SCDO:1000218 SCDO:0004829 ! has manifestation Transient Ischemic Attack
relationship: SCDO:1000218 SCDO:0004836 ! has manifestation Angina
relationship: SCDO:1000218 SCDO:0004847 ! has manifestation Acute Hepatic Sequestration
relationship: SCDO:1000218 SCDO:0004888 ! has manifestation Functional Hyposplenism
relationship: SCDO:1000218 SCDO:0005167 ! has manifestation Chronic Anemia
relationship: SCDO:1000218 SCDO:0005191 ! has manifestation Hyperhemolysis
relationship: SCDO:1000218 SCDO:0006000 ! has manifestation Fever
relationship: SCDO:1000218 SCDO:0006429 ! has manifestation Gallbladder Empyema
relationship: SCDO:1000218 SCDO:0006461 ! has manifestation Acutely Severe Anemia
relationship: SCDO:1000218 SCDO:0006847 ! has manifestation Aplastic Crisis
relationship: SCDO:1000218 SCDO:0006905 ! has manifestation Hypersplenism
relationship: SCDO:1000218 SCDO:0006909 ! has manifestation Hyper-Hemolytic Crisis
relationship: SCDO:1000218 SCDO:0007161 ! has manifestation Acute Splenic Sequestration Crisis
relationship: SCDO:1000218 SCDO:0008037 ! has manifestation Acute Symptomatic Seizure
relationship: SCDO:1000218 SCDO:0008625 ! has manifestation Right Upper Quadrant Syndrome
relationship: SCDO:1000218 SCDO:0008937 ! has manifestation Central Retinal Artery Occlusion
relationship: SCDO:1000218 SCDO:0009117 ! has manifestation Folate Deficiency
relationship: SCDO:1000218 SCDO:0009350 ! has manifestation Splenic Sequestration
relationship: SCDO:1000218 SCDO:0009445 ! has manifestation Renal Papillary Necrosis
relationship: SCDO:1000218 SCDO:0009664 ! has manifestation Abdominal Vaso-Occlusive Crisis
relationship: SCDO:1000218 SCDO:1000376 ! has manifestation Osteonecrosis of the Humeral Head
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 NCIT:C131682
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000549 xsd:string

[Term]
id: NCIT:C133543
name: Crizanlizumab
def: "A humanized monoclonal immunoglobulin G1 anti-P-selectin antibody with vaso-protective and anti-vaso-occlusive properties. Upon administration, crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand-1 (PSGL-1; SELPLG) on neutrophils and monocytes. P-selectin, a glycoprotein that functions as a cell adhesion molecule (CAM), translocates to the surface of activated endothelial cells and platelets, upon stimulation, where it binds to its ligand and mediates the rolling of platelets and neutrophils on activated endothelial cells. Therefore, blockade of p-selectin may inhibit platelet aggregation, maintain blood flow and minimize sickle cell-related pain crises (SCPC)." []
synonym: "Adakveo" EXACT []
synonym: "SEG101" EXACT []
synonym: "SelG1" EXACT []
xref: NCIT:C133543
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0000922 ! Preventative Therapeutics
property_value: http://purl.org/dc/elements/1.1/source https://www.fda.gov/news-events/press-announcements/fda-approves-first-targeted-therapy-treat-patients-painful-complication-sickle-cell-disease
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481200/
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C133543
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000380 xsd:string

[Term]
id: NCIT:C141366
name: Hemoglobin Lepore Syndrome
def: "A rare autosomal recessive hemoglobinopathy, caused by the presence of two deltabeta globin fusion chains, which occurs due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis." []
synonym: "Hb Lepore" EXACT []
synonym: "Hb Lepore Syndrome" EXACT []
synonym: "Homozygous Hb Lepore" EXACT []
synonym: "Homozygous Hemoglobin Lepore" EXACT []
xref: NCIT:C141366
is_a: SCDO:0000343 ! Delta Beta Thalassemia
relationship: SCDO:0000663 CHMO:0001009 ! diagnosed using tool High-Performance Liquid Chromatography
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0000666 ! diagnosed using tool Isoelectric Focusing
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:1000209 ! has causal genotype Crossover between delta (HBD) and beta globin (HBB) gene loci
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000538 xsd:string

[Term]
id: NCIT:C142494
name: Data Storage
def: "To maintain data by placing the data, or a copy of the data, onto an electronically accessible device for preservation (either in plain-text or encrypted format)." []
xref: NCIT:C142494
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C142494
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000420 xsd:string

[Term]
id: NCIT:C142541
name: Research Ethics Committee
def: "An independent group that comprises medical, scientific, and non-scientific members, and is tasked with the continuing review and approval of research, including  clinical trials, with respect to the protocols, methods, and informed consent process to ensure the protection of the rights, safety, and wellbeing of participants." []
synonym: "Ethics Committee" EXACT []
synonym: "Human Subject Protection Committee" EXACT []
synonym: "REC" EXACT []
synonym: "Research Ethics Committee" EXACT []
xref: NCIT:C142541
is_a: SCDO:1000430 ! Ethics Related Concept
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C142541&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009748 xsd:string

[Term]
id: NCIT:C142664
name: Recruitment Period
def: "The interval of time during which subjects are to be enrolled in a clinical study." []
xref: NCIT:C142664
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/ONE/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C142664
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000400 xsd:string

[Term]
id: NCIT:C152089
name: Voxelotor
def: "An orally bioavailable modulator and stabilizer of sickle cell hemoglobin (HbS), with potential use in the treatment of sickle cell disease (SCD). Upon administration, voxelotor targets and covalently binds to the N-terminal valine of the alpha chain of HbS. This stabilizes HbS, thereby improving oxygen binding affinity. The binding of voxelotor to HbS prevents HbS polymerization, reduces sickling, decreases red blood cell (RBC) damage and increases the half-life of RBCs. This improves blood flow and decreases hemolytic anemia." []
comment: Is an accepted therapy for adults and pediatric patients 12 years of age and older with sickle cell disease.
synonym: "GBT-440" EXACT []
synonym: "GBT440" EXACT []
synonym: "Oxbryta" EXACT []
xref: NCIT:C152089
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0000922 ! Preventative Therapeutics
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C152089
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000381 xsd:string

[Term]
id: NCIT:C15238
name: Gene Therapy
def: "Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease." []
synonym: "DNA Therapy" EXACT []
xref: NCIT:C15238
is_a: SCDO:0000301 ! Curative Therapeutics
relationship: SCDO:1000015 DOID:4 ! modifies Disease
relationship: SCDO:1000018 DOID:1584 ! treats Acute Chest Syndrome
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1000018 SCDO:0000518 ! treats Hemoglobin Barts Hydrops Fetalis
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15238 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001344 xsd:string

[Term]
id: NCIT:C15320
name: Study Design
def: "A plan detailing how a study will be performed in order to represent the phenomenon under examination, to answer the research questions that have been asked, and defining the methods of data analysis. Study design is driven by research hypothesis being posed, study subject/population/sample available, logistics/resources: technology, support, networking, collaborative support, etc." []
synonym: "Experiment Design" EXACT []
synonym: "Experimental Design" EXACT []
synonym: "Research Design" EXACT []
synonym: "STYPE" EXACT []
xref: NCIT:C15320
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000303 "Review current sub-classes in light of and include relevant classes from \"EDDA Study Designs Taxonomy\" to be added as sub-classes." xsd:string
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15320
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001115 xsd:string

[Term]
id: NCIT:C154481
name: Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)
def: "A patient-reported outcome measurement system designed to evaluate and monitor the physical, mental, and social well-being of adults with sickle cell disease." []
comment: It includes questions that enable adults with SCD to describe their functioning and well-being. Its measures are available as 5 item short forms or can be administered as computer adaptive tests. Measures include: Pain Impact; Stiffness Impact (5-item short form); Sleep Impact; Social Functioning Impact; Emotional Impact; Pain Episodes; and  Pain Frequency.
synonym: "Adult Sickle Cell Quality of Life Measurement Information System" EXACT []
synonym: "Adult Sickle Cell Quality-of-Life Measurement Information System" EXACT []
synonym: "ASCQ-Me" EXACT []
xref: NCIT:C154481
is_a: SCDO:0000952 ! Quality of Life in Sickle Cell Disease Measure
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/820201
property_value: http://purl.org/dc/elements/1.1/source "Keller SD, Yang M, Treadwell MJ, Werner EM, Hassell KL (2014).Patient reports of health outcome for adults living with sickle cell disease: development and testing of the ASCQ-Me item banks. Health and Quality of Life Outcomes,12,125." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C154481
property_value: SCDO:0000470 "Cross-cultural adaptation underway in Brazil. ASCQ-Me's development using modern measurement theory facilitates cross cultural adaptation." xsd:string
property_value: SCDO:0000479 "PhenX protocol: Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me) #820201" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic Patients (Adults with SCD)" xsd:string
property_value: SCDO:0000484 "Spanish; Portuguese" xsd:string
property_value: SCDO:0000486 "This measure can be used to track health status and treatment outcomes and understand the health care requirements of patients with chronic conditions, such as sickle cell disease (SCD)." xsd:string
property_value: SCDO:0001033 "Rigor in development, using modern measurement theory and aligned with PROMIS measurement development." xsd:string
property_value: SCDO:0001222 "18 years and older" xsd:string
property_value: SCDO:0001335 "no" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000027 xsd:string

[Term]
id: NCIT:C154865
name: Cerebral Blood Flow Assay
def: "An evaluation of the perfusion of blood through the brain." []
synonym: "Cerebral Blood Flow Assessment" EXACT []
synonym: "Cerebral Blood Flow Measurement" EXACT []
synonym: "Stroke Risk Test" EXACT []
xref: NCIT:C154865
is_a: SCDO:0000208 ! Cerebral Function Assay
is_a: SCDO:1000316 ! Blood Flow Test
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C154865
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000204 xsd:string

[Term]
id: NCIT:C155310
name: Sickle Cell Disease-SD
def: "A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin D mutations. Patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin SS disease." []
synonym: "Haemoglobin S-D Disease" EXACT []
synonym: "Hb SD-Disease" EXACT []
synonym: "Hemoglobin S-D Disease" EXACT []
synonym: "Hemoglobin Sickle D Disease" EXACT []
synonym: "Sickle Cell Disease SD" EXACT []
synonym: "Sickle Cell Hemoglobin D Disease" EXACT []
synonym: "Sickle Cell-Haemoglobin D Disease" EXACT []
synonym: "Sickle Cell-Hemoglobin D Disease" EXACT []
xref: NCIT:C155310
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0000664 NCIT:C15238 ! treated with Gene Therapy
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:0000664 SCDO:0000771 ! treated with Morphine
relationship: SCDO:0000664 SCDO:0001329 ! treated with Folic Acid
relationship: SCDO:0000664 SCDO:0008888 ! treated with Iron Chelation Therapy
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000054 ! has causal genotype Hemoglobin Genotype SD
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000108 ! has causal or contributing genetic variation HBB, SER9TYR
relationship: SCDO:1000210 SCDO:1000109 ! has causal or contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000210 SCDO:1000110 ! has causal or contributing genetic variation HBB, GLY16ARG
relationship: SCDO:1000210 SCDO:1000111 ! has causal or contributing genetic variation HBB, ASN19LYS
relationship: SCDO:1000210 SCDO:1000112 ! has causal or contributing genetic variation HBB, GLU22GLN
relationship: SCDO:1000210 SCDO:1000113 ! has causal or contributing genetic variation HBB, GLU22VAL
relationship: SCDO:1000210 SCDO:1000114 ! has causal or contributing genetic variation HBB, THR87LYS
relationship: SCDO:1000210 SCDO:1000115 ! has causal or contributing genetic variation HBB, GLU121ALA
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000007 ! has causal molecular phenotype Hemoglobin D
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C155310
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001060 xsd:string

[Term]
id: NCIT:C155312
name: Sickle Cell Chronic Lung Disease
def: "A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present." []
synonym: "Sickle Cell Chronic Restrictive Lung Disease" EXACT []
xref: NCIT:C155312
is_a: SCDO:0000232 ! Chronic Restrictive Lung Disease
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000071 ! diagnosed using tool Arterial Blood Gas Test
relationship: SCDO:0000663 SCDO:0000217 ! diagnosed using tool Chest X-Ray
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000663 SCDO:0000942 ! diagnosed using tool Pulmonary Function Test
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source "Powars et al 1988 Medicine (Baltimore), Knight-Madden et al 2010 Lung." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C155312
property_value: SCDO:0000662 "Restricive lung disease often associated with chest pain and hypoxemia.  May also be associated with pulmonary hypertension." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001046 xsd:string

[Term]
id: NCIT:C155932
name: Global Mental Status Screener - Older Children and Adolescents
def: "A clinician-assessed rating of psychological and social functioning in children ages six to seventeen that was developed by Shaffer et al. in 1983. The numerical scale, which is an adaptation of the adult Global Assessment Scale (GAS) developed by Endicott et al in 1976, is scored from 0 to 100 based on behaviors and life situations that are applicable to children." []
synonym: "CGAS" EXACT []
synonym: "Children’s Global Assessment Scale" EXACT []
synonym: "Children’s Global Assessment Scale (CGAS)" EXACT []
xref: NCIT:C155932
is_a: SCDO:0000455 ! Global Mental Status Screener
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/130703
property_value: SCDO:0000340 "details"
property_value: SCDO:0000479 "PhenX protocol: Global Mental Status Screener - Older Children and Adolescents #130703" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000334 xsd:string

[Term]
id: NCIT:C156541
name: Separated
def: "A person who is separated from their spouse, whether or not there is a legal arrangement." []
xref: NCIT:C156541
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 NCIT:C156541
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000677 xsd:string

[Term]
id: NCIT:C15709
name: Genetic Testing
def: "The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder." []
synonym: "Genetic Analysis" EXACT []
synonym: "Genetic Examination" EXACT []
synonym: "Genetic Test" EXACT []
xref: NCIT:C15709
is_a: SCDO:0000448 ! Genetic Technique
property_value: SCDO:0000303 "Note: \"Genetic Test\" is a SNOMED CT term.\n\nInclude NCIT's \"Presymptomatic Testing\" as a sub-class?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15709 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000449 xsd:string

[Term]
id: NCIT:C15900
name: Lifestyle Therapy
def: "Therapy dealing with lifestyle management and includes: behavioral and dietary modifications, exercise, stress management, and addiction control. This therapy must be used as major adjunct to 'standard care' or be applied as alternative treatment to conventional medicine practices." []
xref: NCIT:C15900
is_a: SCDO:0001152 ! Therapeutics
relationship: SCDO:1000018 HP:0000819 ! treats Diabetes Mellitus
relationship: SCDO:1000018 HP:0002870 ! treats Obstructive Sleep Apnea
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15900
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000006 xsd:string

[Term]
id: NCIT:C1643
name: Polyvalent Pneumococcal Vaccine
def: "An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years." []
synonym: "Pneumococcal Polysaccharide Vaccine" EXACT []
synonym: "Pneumococcal Polyvalent Vaccine" EXACT []
synonym: "PPSV" EXACT []
xref: NCIT:C1643
is_a: VO:0000675 ! Streptococcus Pneumoniae Vaccine
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C1643&jump_to_nav=true xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000915 xsd:string

[Term]
id: NCIT:C164339
name: Date of Diagnosis
def: "The date on which a diagnosis of disease was made." []
xref: NCIT:C164339
is_a: SCDO:1000538 ! Diagnosis Temporal Observable
property_value: SCDO:0000340 NCIT:C164339
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000557 xsd:string

[Term]
id: NCIT:C16453
name: Community
def: "A set of people with some shared element. The substance of shared element varies widely, from geography to a situation to interest to lives and values. The term is widely used to evoke sense of collectivity." []
xref: NCIT:C16453
is_a: SCDO:0001082 ! Social Environment
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16453
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000266 xsd:string

[Term]
id: NCIT:C16495
name: Demographic Factor
def: "The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income)." []
synonym: "Demographic Factors" EXACT []
synonym: "Demographics" EXACT []
synonym: "Demography" EXACT []
synonym: "Population Studies / Demography" EXACT []
xref: NCIT:C16495
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16495
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000468 xsd:string

[Term]
id: NCIT:C16564
name: Ethnic Group
def: "A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease." []
synonym: "Ethnic Origin" EXACT []
synonym: "Ethnic Origins" EXACT []
synonym: "Ethnicity" EXACT []
xref: NCIT:C16564
is_a: SCDO:0001551 ! Ethnolinguistics
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
property_value: SCDO:0000303 "Include other Ethnic groups that are sub-classes of \"Ethnic Group\" in ERO." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16564 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001298 xsd:string

[Term]
id: NCIT:C16567
name: Exercise
def: "Activity that requires physical or mental exertion, especially when performed to develop or maintain fitness." []
xref: NCIT:C16567
is_a: NCIT:C15900 ! Lifestyle Therapy
is_a: SCDO:0000487 ! Health Behaviour
relationship: SCDO:1000018 HP:0000842 ! treats Hyperinsulinemia
relationship: SCDO:1000018 HP:0000855 ! treats Insulin Resistance
relationship: SCDO:1000018 HP:0000938 ! treats Osteopenia
relationship: SCDO:1000018 HP:0000939 ! treats Osteoporosis
relationship: SCDO:1000018 HP:0001382 ! treats Joint Hypermobility
relationship: SCDO:1000018 HP:0002076 ! treats Migraine
relationship: SCDO:1000018 HP:0002808 ! treats Kyphosis
relationship: SCDO:1000018 HP:0003611 ! treats Dyslipidemia
relationship: SCDO:1000018 SCDO:0001168 ! treats Transient Monocular Blindness
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16567
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001305 xsd:string

[Term]
id: NCIT:C16576
name: Female
def: "A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both." []
xref: NCIT:C16576
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 NCIT:C16576
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000560 xsd:string

[Term]
id: NCIT:C16612
name: Gene
def: "A functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function." []
xref: NCIT:C16612
is_a: SCDO:0005722 ! Genetic Structure
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16612
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000359 xsd:string

[Term]
id: NCIT:C16632
name: Geographic Area
def: "Any demarcated area of the Earth; may be determined by both natural and human boundaries." []
synonym: "Geographic Location" EXACT []
synonym: "Geographic Region" EXACT []
xref: NCIT:C16632
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16632&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000367 xsd:string

[Term]
id: NCIT:C16676
name: Hemoglobin
def: "The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb." []
synonym: "Hb" EXACT []
synonym: "Hgb" EXACT []
xref: NCIT:C16676
is_a: NCIT:C26548 ! Gene Product
property_value: SCDO:0000340 NCIT:C16676
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009453 xsd:string

[Term]
id: NCIT:C16723
name: Immunological Assay
def: "Laboratory test involving interaction of antigens with specific antibodies." []
synonym: "Immunoassay" EXACT []
synonym: "Immunological Laboratory Method" EXACT []
synonym: "Immunology Test" EXACT []
xref: NCIT:C16723
is_a: SCDO:0000120 ! Biochemical Assay
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16723
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000617 xsd:string

[Term]
id: NCIT:C16779
name: Language
def: "A systematic means of communicating by the use of sounds, symbols, or gestures." []
xref: NCIT:C16779
is_a: SCDO:0001551 ! Ethnolinguistics
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C16779 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005364 xsd:string

[Term]
id: NCIT:C16809
name: Magnetic Resonance Imaging
def: "Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders." []
synonym: "Magnetic Resonance Imaging Scan" EXACT []
synonym: "Magnetic Resonance Tomography" EXACT []
synonym: "MIR Scan" EXACT []
synonym: "MRI" EXACT []
synonym: "MRT" EXACT []
synonym: "NMR Imaging" EXACT []
synonym: "NMRI" EXACT []
synonym: "Nuclear Magnetic Resonance Imaging" EXACT []
xref: NCIT:C16809
is_a: OBI:0000185 ! Imaging Assay
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C16809 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000708 xsd:string

[Term]
id: NCIT:C168823
name: Year of Diagnosis
def: "The year when a diagnosis was assigned to an individual's condition." []
xref: NCIT:C168823
is_a: SCDO:1000538 ! Diagnosis Temporal Observable
property_value: SCDO:0000340 NCIT:C168823
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000567 xsd:string

[Term]
id: NCIT:C17004
name: Genetic Polymorphism
def: "The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site to large nucleotide sequences visible at a chromosomal level." []
xref: NCIT:C17004
is_a: SCDO:0001369 ! Genetic Variation
property_value: SCDO:0000340 NCIT:C17004
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004047 xsd:string

[Term]
id: NCIT:C17047
name: Quality of Life
def: "The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness." []
synonym: "Health Related Quality of Life" EXACT []
synonym: "QOL" EXACT []
xref: NCIT:C17047
is_a: SCDO:0000950 ! Quality of Life and Care
relationship: SCDO:1000005 DOID:4 ! modified by Disease
relationship: SCDO:1000005 SCDO:0000746 ! modified by Mental Health
relationship: SCDO:1000005 SCDO:0000900 ! modified by Physical Functioning
relationship: SCDO:1000005 SCDO:0000948 ! modified by Quality of Health Care
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17047&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000949 xsd:string

[Term]
id: NCIT:C17049
name: Race
def: "An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution." []
synonym: "Racial Group" EXACT []
xref: NCIT:C17049
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
property_value: SCDO:0000303 "Different relevant racial groups need to be recorded. Perhaps as sub-classes of this class? \nThe PhenX protocol is U.S. specific.  Is there one relevant to the African setting?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17049 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000962 xsd:string

[Term]
id: NCIT:C17230
name: Ultrasound Test
def: "A technique in which high-frequency sound waves are bounced off internal organs and the echo pattern is converted into a 2 dimensional picture of the structures beneath the transducer." []
synonym: "Immaging by Ultrasonography" EXACT []
synonym: "Ultrasonography" EXACT []
synonym: "Ultrasound" EXACT []
synonym: "Ultrasound Imaging" EXACT []
xref: NCIT:C17230
is_a: OBI:0000185 ! Imaging Assay
relationship: SCDO:1000192 OBI:0001098 ! uses diagnostic device Ultrasound Machine
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17230 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000614 xsd:string

[Term]
id: NCIT:C17241
name: Urine Test
def: "Laboratory analysis of urine, commonly used to aid in the diagnosis of disease or to detect the presence of a specific substance. It involves examination of the urine by physical or chemical means as well as microscopic examination that helps to screen for urinary tract infections, renal disease, and diseases of other organs, that result in abnormal metabolites (break-down products) appearing in the urine." []
synonym: "Urinalysis" EXACT []
synonym: "Urine Analysis" EXACT []
xref: NCIT:C17241
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000303 "Other urine tests to be added as sub-classes? There are many in the NCIT." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17241
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001216 xsd:string

[Term]
id: NCIT:C173396
name: Cerebral Blood Flow Velocity
def: "The rate of blood flow through the cerebral arteries." []
synonym: "CBF Velocity" EXACT []
synonym: "CBFV" EXACT []
synonym: "Transcranial Doppler Velocity" EXACT []
xref: NCIT:C173396
is_a: SCDO:0000213 ! Cerebrovascular Hemodynamics
relationship: SCDO:1000190 SCDO:0001114 ! obtained via diagnostic tool Stroke Risk Test in Children with Sickle Cell Disease
relationship: SCDO:1000190 SCDO:0001166 ! obtained via diagnostic tool Transcranial Doppler Ultrasonography
property_value: SCDO:0000340 ConceptReport.jsp?dictionary=NCI:Thesaurus&ns=ncit&code=C173396
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000205 xsd:string

[Term]
id: NCIT:C17357
name: Gender
def: "The assemblage of properties that distinguish people on the basis of the societal roles expected for the two sexes." []
xref: NCIT:C17357
is_a: NCIT:C16495 ! Demographic Factor
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17357
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001341 xsd:string

[Term]
id: NCIT:C17655
name: Reproductive History
def: "An account of all reproductive events and problems a person has experienced. An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage." []
xref: NCIT:C17655
is_a: NCIT:C18772 ! Personal Medical History
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17655
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000346 xsd:string

[Term]
id: NCIT:C17873
name: Psychosocial Effect
def: "Having to do with the physical, psychological, cognitive, and social consequences of disease, including stigmatization of persons affected." []
synonym: "Psychosocial Effects" EXACT []
synonym: "Psychosocial Effects/Treatment" EXACT []
xref: NCIT:C17873
is_a: SCDO:0000746 ! Mental Health
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17873 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000939 xsd:string

[Term]
id: NCIT:C18133
name: Missense Mutation
def: "A single base pair substitution that alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position. Some missense mutations will alter the function of the protein." []
xref: NCIT:C18133
is_a: NCIT:C62200 ! Point Mutation
property_value: SCDO:0000340 NCIT:C18133
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004314 xsd:string

[Term]
id: NCIT:C18772
name: Personal Medical History
def: "A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies." []
synonym: "General Medical History" EXACT []
synonym: "Medical History" EXACT []
synonym: "Past Medical History" EXACT []
synonym: "PMH" EXACT []
xref: NCIT:C18772
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
property_value: SCDO:0000303 "Sub-classes in NCIT to be added here." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C18772 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000891 xsd:string

[Term]
id: NCIT:C19228
name: Optical Instrument
def: "An instrument used to measure an event involving emission, absorption, or refraction of light." []
xref: NCIT:C19228
is_a: OBI:0400169 ! Microscope
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C19228 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000837 xsd:string

[Term]
id: NCIT:C19296
name: Deletion Mutation
def: "Any rearrangement to the genomic content that results in the loss of one or more nucleotides of DNA. Deletions are generally irreversible rearrangements. They may alter the reading frame of a gene, or may result in loss of large chromosomal regions." []
synonym: "Deletion Abnormality" EXACT []
xref: NCIT:C19296
is_a: IDOMAL:50000026 ! Mutation
relationship: SCDO:1000015 NCIT:C26548 ! modifies Gene Product
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C19296 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001371 xsd:string

[Term]
id: NCIT:C19332
name: Personal Attribute
def: "The distinguishing qualities or prominent aspects of an individual person." []
synonym: "Subject Characteristics" EXACT []
xref: NCIT:C19332
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000303 "Populate this class with demographic terms from PhenX and elsewhere. Some terms will be duplicated in QoL. --  -- Add these from PhenX?: -- - Acculturation -- - Residential History --  -- Also look at other sub-classes in NCIT." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C19332 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000890 xsd:string

[Term]
id: NCIT:C19771
name: Molecular Profiling Assay
def: "Analysis of the RNA expression pattern in a tissue sample using molecular techniques." []
synonym: "Expression Profiling" EXACT []
synonym: "Molecular Fingerprinting" EXACT []
synonym: "Molecular Profiling" EXACT []
xref: NCIT:C19771
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C19771
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000768 xsd:string

[Term]
id: NCIT:C20197
name: Male
def: "A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both." []
xref: NCIT:C20197
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 NCIT:C20197
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000559 xsd:string

[Term]
id: NCIT:C20629
name: Silent Mutation
def: "A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected." []
synonym: "Exon Synonymous Mutation" EXACT []
synonym: "Exonic Synonymous Mutation" EXACT []
synonym: "Synonymous Mutation" EXACT []
xref: NCIT:C20629
is_a: NCIT:C62200 ! Point Mutation
property_value: SCDO:0000340 NCIT:C20629
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005439 xsd:string

[Term]
id: NCIT:C20711
name: SP1 Gene
def: "This gene plays a role in transcriptional regulation and is involved in several signal transduction pathways." []
synonym: "SP1" EXACT []
synonym: "Sp1 Transcription Factor Gene" EXACT []
xref: NCIT:C20711
is_a: NCIT:C16612 ! Gene
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C20711
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000393 xsd:string

[Term]
id: NCIT:C25150
name: Age
def: "How long something has existed; elapsed time since birth." []
synonym: "Aged" EXACT []
synonym: "Chronological Age" EXACT []
synonym: "Postnatal Age" EXACT []
xref: NCIT:C25150
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
property_value: SCDO:0000303 "Could add many sub-classes of \"Age\" from NCIT." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C25150 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000030 xsd:string

[Term]
id: NCIT:C25191
name: Person Name
def: "A word or group of words indicating the identity of a person usually consisting of a first (personal) name and a last (family) name with an optional middle name. In some cultural traditions the family name comes first." []
synonym: "Contact Name" EXACT []
synonym: "Individual's Name" EXACT []
synonym: "Name" EXACT []
synonym: "Name of Person" EXACT []
synonym: "Person.name" EXACT []
xref: NCIT:C25191
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 "C25191"
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000859 xsd:string

[Term]
id: NCIT:C25298
name: Systolic Blood Pressure
def: "The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart." []
synonym: "SYSBP" EXACT []
synonym: "systolic bp" EXACT []
synonym: "Systolic Pressure" EXACT []
xref: NCIT:C25298
is_a: CMO:0000003 ! Blood Pressure Measurement
property_value: SCDO:0000340 NCIT:C25298
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000892 xsd:string

[Term]
id: NCIT:C25299
name: Diastolic Blood Pressure
def: "The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling." []
synonym: "DIABP" EXACT []
synonym: "Diastolic Pressure" EXACT []
xref: NCIT:C25299
is_a: CMO:0000003 ! Blood Pressure Measurement
property_value: SCDO:0000340 NCIT:C25299
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000739 "6" xsd:integer
property_value: SCDO:1000910 SCDO:1000893 xsd:string

[Term]
id: NCIT:C25460
name: Consent
def: "Permission to do something." []
xref: NCIT:C25460
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:0007597 ! Descriptor of Consent
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C25460 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001466 xsd:string

[Term]
id: NCIT:C25464
name: deprecated Country
def: "A collective generic term that refers here to a wide variety of dependencies, areas of special sovereignty, uninhabited islands, and other entities in addition to the traditional countries or independent states." []
xref: NCIT:C25464
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C25464 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004140 xsd:string
is_obsolete: true
replaced_by: SCDO:0000792

[Term]
id: NCIT:C25474
name: Data
def: "A collection or single item of factual or reported information, derived from measurement or research, from which conclusions may be drawn." []
xref: NCIT:C25474
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C25474
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006670 xsd:string

[Term]
id: NCIT:C258
name: Antibiotic
def: "Substances naturally produced by microorganisms or their derivatives that selectively target microorganisms not humans. Antibiotics kill or inhibit the growth of microorganisms by targeting components of the microbial cell absent from human cells, including bacterial cell walls, cell membrane, and 30S or 50S ribosomal subunits. These substances are used in the treatment of bacterial and other microbial infections." []
synonym: "Antibiotic Agents" EXACT []
synonym: "Antibiotic Drug" EXACT []
synonym: "Antibiotic Drugs" EXACT []
synonym: "Antibiotics" EXACT []
synonym: "Antimicrobial" EXACT []
synonym: "Antimicrobial Agent" EXACT []
xref: NCIT:C258
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 DOID:1584 ! treats Acute Chest Syndrome
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 HP:0000132 ! treats Menorrhagia
relationship: SCDO:1000018 HP:0000388 ! treats Otitis Media
relationship: SCDO:1000018 HP:0000999 ! treats Pyoderma
relationship: SCDO:1000018 HP:0001061 ! treats Acne
relationship: SCDO:1000018 HP:0001287 ! treats Meningitis
relationship: SCDO:1000018 HP:0006689 ! treats Bacterial Endocarditis
relationship: SCDO:1000018 HP:0008404 ! treats Nail Dystrophy
relationship: SCDO:1000018 HP:0030049 ! treats Brain Abscess
relationship: SCDO:1000018 HP:0030127 ! treats Endometriosis
relationship: SCDO:1000018 HP:0100806 ! treats Sepsis
relationship: SCDO:1000018 MP:0002412 ! treats Increased Susceptibility to Bacterial Infection
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1000018 NCIT:C95504 ! treats Hemoglobin H Disease
relationship: SCDO:1000018 SCDO:0000088 ! treats Atopic Dermatitis
relationship: SCDO:1000018 SCDO:0000812 ! treats Non-specific Acute Lower Respiratory Tract Episode
relationship: SCDO:1000018 SCDO:0000840 ! treats Osteomyelitis
relationship: SCDO:1000018 SCDO:0001073 ! treats Skin Rash
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C258 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000059 xsd:string

[Term]
id: NCIT:C26548
name: Gene Product
def: "A protein, RNA or a complex that contains proteins and/or RNA." []
synonym: "Genome Encoded Entity" EXACT []
xref: NCIT:C26548
is_a: SCDO:0001000 ! SCDO
relationship: SCDO:1000005 IDOMAL:50000026 ! modified by Mutation
relationship: SCDO:1000005 NCIT:C19296 ! modified by Deletion Mutation
relationship: SCDO:1000005 NCIT:C62200 ! modified by Point Mutation
property_value: SCDO:0000303 "If additional gene products are included in the future, they can be categorised according to those below this term in the \"National Cancer Institute Thesaurus\" (NCIT)" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C26548 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001343 xsd:string

[Term]
id: NCIT:C26702
name: Ataxia
def: "Lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Causes include peripheral nerve disorders, posterior column injuries, cerebral and cerebellar disorders, basal ganglia disorders, and thalamic disorders." []
xref: NCIT:C26702
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 OGMS:0000088 ! diagnosed using tool Patient Symptom Report
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000664 SCDO:0000822 ! treated with Occupational Therapy
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Perhaps add \"Cerebellar Ataxia\" subclass?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C26702
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000087 xsd:string

[Term]
id: NCIT:C27088
name: Hyperbilirubinemia
def: "Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice." []
synonym: "High Blood Bilirubin Levels" EXACT []
xref: NCIT:C27088
is_a: HP:0032180 ! Abnormal Circulating Metabolite Concentration
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C27088
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003118 xsd:string

[Term]
id: NCIT:C27222
name: Cerebral Aneurysm
def: "A balloon type pouch or bulge in the wall of a cerebral blood vessel." []
synonym: "Brain Aneurysm" EXACT []
synonym: "Cerebral Artery Aneurysm" EXACT []
synonym: "Dilatation of the Cerebral Artery" EXACT []
synonym: "Intracranial Aneurysm" EXACT []
xref: NCIT:C27222
is_a: HP:0002060 ! Abnormality of the Cerebrum
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 "details"
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000202 xsd:string

[Term]
id: NCIT:C28407
name: National Origin
def: "System of classification based on nation from which a person originates, regardless of the nation in which he/she currently resides." []
synonym: "Birth Country" EXACT []
synonym: "Country of Birth" EXACT []
synonym: "Country of Origin" EXACT []
xref: NCIT:C28407
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0001090 ! Socioeconomic Factors
property_value: SCDO:0000303 "Include list of nations below." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C28407 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000792 xsd:string

[Term]
id: NCIT:C28421
name: Sex
def: "The totality of characteristics of reproductive structure, functions, phenotype, and genotype, differentiating the male from the female organism." []
synonym: "Participant Sex" EXACT []
synonym: "Participant's Sex" EXACT []
synonym: "Respondent's Sex" EXACT []
synonym: "Sex of Participant" EXACT []
xref: NCIT:C28421
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0000122 ! Biological Disease Modifier
property_value: SCDO:0000340 NCIT:C28421
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000671 xsd:string

[Term]
id: NCIT:C28516
name: Sickle Cell Dactylitis
def: "A severe acute inflammatory response affecting the hands and feet of individuals with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and finally infarction of the distal portions of the extremities. Clinical signs of pain, swelling and tenderness of digits usually begin in early childhood and may be the initial manifestations of sickle cell anemia. Clinical course is self-limited with instances typically lasting a few weeks and occurring during sickling crises. An initial episode before the age of 1 strongly correlates with a more severe disease course." []
xref: NCIT:C28516
is_a: HP:0002715 ! Abnormality of the Immune System
is_a: SCDO:0001023 ! SCD Related Pain
relationship: SCDO:1000202 SCDO:0008623 ! caused by Vaso-Occlusion
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C28516 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000477 xsd:string

[Term]
id: NCIT:C2890
name: Bacterial Infection
def: "An acute infectious disorder caused by gram positive or gram negative bacteria. Representative examples include pneumococcal, streptococcal, salmonella and meningeal infections." []
xref: NCIT:C2890
is_a: IDO:0000586 ! Infection
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Perhaps use as Disease Modifier?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2890 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000100 xsd:string

[Term]
id: NCIT:C2905
name: Bone Marrow Hyperplasia
def: "Increase in the number of hematopoietic cells in the bone marrow. It may involve all or individual hematopoietic cell lines." []
synonym: "Hyperplasia of Bone Marrow" EXACT []
synonym: "Marrow Hyperplasia" EXACT []
xref: NCIT:C2905
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C2905 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007438 xsd:string

[Term]
id: NCIT:C29091
name: Hepatitis B Vaccine
def: "A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection." []
synonym: "ENGERIX-B" EXACT []
synonym: "Hepatitis B Vaccine (Recombinant)" EXACT []
synonym: "Recombinant Hepatitis B Vaccine" EXACT []
synonym: "RECOMBIVAX HB" EXACT []
xref: NCIT:C29091
is_a: VO:0000001 ! Vaccine
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C29091 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008062 xsd:string

[Term]
id: NCIT:C29107
name: IV fluids
def: "A sterile liquid preparation infused into a vein. IV fluid is prescribed as a replacement of fluid, electrolytes, calories, vitamins, and other nutritional substances. In addition, IV fluids are used to administer blood products and medications such as chemotherapy. Examples of IV fluids include Normal Saline, Ringers Solution, and Lactated Ringers Solution." []
synonym: "Intravenous Fluid" EXACT []
xref: NCIT:C29107
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C29107 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005247 xsd:string

[Term]
id: NCIT:C2959
name: Complication
def: "Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure." []
synonym: "Complications" EXACT []
synonym: "Medical Complication" EXACT []
xref: NCIT:C2959
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C2959d
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000384 xsd:string

[Term]
id: NCIT:C29719
name: Smoking History
def: "A record of an individual's background in regard to smoking tobacco. This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others." []
synonym: "Tobacco Smoking History" EXACT []
xref: NCIT:C29719
is_a: SCDO:0001120 ! Substance Use History
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C29719 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001081 xsd:string

[Term]
id: NCIT:C30142
name: History of Transfusion
def: "An account of all experiences related to the receipt of blood, WBC, platelets, and/or other blood components." []
synonym: "Transfusion History" EXACT []
xref: NCIT:C30142
is_a: NCIT:C18772 ! Personal Medical History
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C30142
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000569 xsd:string

[Term]
id: NCIT:C3245
name: Fungal Infection
def: "An infection caused by a fungus." []
xref: NCIT:C3245
is_a: IDO:0000586 ! Infection
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C3245&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000349 xsd:string

[Term]
id: NCIT:C3439
name: Viral Infection
def: "Any disease caused by a virus." []
synonym: "Viral Disease" EXACT []
synonym: "Virus Disease" EXACT []
xref: NCIT:C3439
is_a: IDO:0000586 ! Infection
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Perhaps use as Disease Modifier?\n\nAdd these sub-classes:\nHepatitis C Infection (term in NCIT)\nHepatitis B Infection (term in NCIT)\nHIV Infection (term in NCIT)" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C3439 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001233 xsd:string

[Term]
id: NCIT:C34465
name: Cholecystitis
def: "An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones." []
xref: NCIT:C34465
is_a: HP:0025031 ! Abnormality of the Digestive System
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C34465 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007856 xsd:string

[Term]
id: NCIT:C34887
name: Peri-Operative Pain
def: "A sensation of discomfort secondary to surgery." []
synonym: "Perioperative Pain" EXACT []
synonym: "Post Surgery Pain" EXACT []
synonym: "Post-Operative Pain" EXACT []
synonym: "Postoperative Pain" EXACT []
xref: NCIT:C34887
is_a: SCDO:0000851 ! Pain
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C34887
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000451 xsd:string

[Term]
id: NCIT:C34941
name: Pregnancy Complication
def: "The co-occurrence of pregnancy and a disease. The disease may precede or follow conception and it may or may not have a deleterious effect on the pregnant woman or fetus." []
synonym: "Complication Related to Pregnancy" EXACT []
xref: NCIT:C34941
is_a: NCIT:C2959 ! Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C34941
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000399 xsd:string

[Term]
id: NCIT:C35069
name: Thalassemia
def: "An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation." []
xref: NCIT:C35069
is_a: SCDO:0007192 ! Quantitative Hemoglobinopathy
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 NCIT:C35069
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001144 xsd:string

[Term]
id: NCIT:C35146
name: Chronic Cholecystitis
def: "Cholecystitis that is persistent and long-standing." []
xref: NCIT:C35146
is_a: NCIT:C34465 ! Cholecystitis
is_a: SCDO:0001334 ! Chronic Phenotype
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C35146 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009201 xsd:string

[Term]
id: NCIT:C35152
name: Acute Cholecystitis
def: "Acute inflammation of the gallbladder." []
xref: NCIT:C35152
is_a: NCIT:C34465 ! Cholecystitis
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C35152 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008927 xsd:string

[Term]
id: NCIT:C35372
name: Ascending Cholangitis
def: "Acute infection of the bile ducts caused by bacteria ascending from the small intestine." []
xref: NCIT:C35372
is_a: HP:0025031 ! Abnormality of the Digestive System
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C35372 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008766 xsd:string

[Term]
id: NCIT:C35447
name: Osteonecrosis of the Femoral Head
def: "Necrotic changes in the bone tissue of the femoral head due to interruption of blood supply." []
synonym: "Avascular Necrosis of Femoral Head" EXACT []
synonym: "Avascular Necrosis of the Capital Femoral Epiphysis" EXACT []
synonym: "Avascular Necrosis of the Femoral Head" EXACT []
synonym: "Avascular Necrosis of the Head of Femur" EXACT []
synonym: "ONFH" EXACT []
xref: NCIT:C35447
is_a: HP:0010885 ! Osteonecrosis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Add description. -- See HPO term \"Avascular necrosis of the capital femoral epiphysis\". --  -- Perhaps add \"Bone decompression by drilling\" to therapeutics and link to it with \"is treated with" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C35447 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000842 xsd:string

[Term]
id: NCIT:C3671
name: Injury
def: "Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity." []
synonym: "Trauma" EXACT []
synonym: "Wound" EXACT []
xref: NCIT:C3671
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C3671
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000435 xsd:string

[Term]
id: NCIT:C38060
name: Eye Examination
def: "A test performed by an ophthalmologist or optometrist assessing vision and ability to focus on and discern objects, as well as other tests and examinations pertaining to the eyes." []
synonym: "Eye Exam" EXACT []
xref: NCIT:C38060
is_a: SCDO:0000898 ! Physical Examination
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C38060 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001313 xsd:string

[Term]
id: NCIT:C38085
name: Pulse Oximetry
def: "A non-invasive method that provides estimates of arterial oxyhemoglobin saturation by utilizing selected wavelengths of light to determine the saturation of oxyhemoglobin." []
xref: NCIT:C38085
is_a: SCDO:0000942 ! Pulmonary Function Test
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C38085
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000351 xsd:string

[Term]
id: NCIT:C38141
name: Pneumococcal 7-Valent Conjugate Vaccine
def: "An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein." []
synonym: "7 Valent PncOMPC Vaccine" EXACT []
synonym: "7-Valent PncOMPC Vaccine" EXACT []
synonym: "Heptavalent Pneumococcal Conjugate Vaccine" EXACT []
synonym: "PCV 7" EXACT []
synonym: "PCV7 Vaccine" EXACT []
synonym: "Pneumococcal 7-Valent Conjugate Vaccine (Diphtheria CRM197 Protein)" EXACT []
synonym: "Prevenar" EXACT []
synonym: "Prevnar" EXACT []
synonym: "Seven Valent Pneumococcal PS Meningococcal OMPC Conjugate Vaccine" EXACT []
synonym: "Seven-Valent Pneumococcal PS-Meningococcal OMPC Conjugate Vaccine" EXACT []
xref: NCIT:C38141
is_a: NCIT:C97123 ! Conjugate Pneumococcal Vaccine
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C38141 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000911 xsd:string

[Term]
id: NCIT:C3833
name: Asymptomatic
def: "Without clinical signs or indications that raise the possibility of a particular disorder or dysfunction." []
synonym: "No Symptoms" EXACT []
xref: NCIT:C3833
is_a: OGMS:0000023 ! Phenotype
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C3833
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004802 xsd:string

[Term]
id: NCIT:C38698
name: Hyperviscosity
def: "An increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity." []
synonym: "Blood Hyperviscosity" EXACT []
synonym: "Hypercoagulability" EXACT []
synonym: "Thrombophilia" EXACT []
xref: NCIT:C38698
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C38698 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002771 xsd:string

[Term]
id: NCIT:C3890
name: Hypoxia
def: "A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). In SCD patients, this is considered as saturated oxygen < 95% on air." []
xref: NCIT:C3890
is_a: HP:0002086 ! Abnormality of the Respiratory System
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Have merged the definition of hypoxia from NCIT and the Tanzanian Management Guidelines. Not sure if the SaO2 value is specific to SCD patients - please get a clinician to review.\n\nThis is a symptom of acute chest syndrome." xsd:string
property_value: SCDO:0000340 NCIT:C3890
property_value: SCDO:0000340 "SCD Management guidelines - Tanzania" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004183 xsd:string

[Term]
id: NCIT:C39547
name: Treatment Efficacy
def: "The probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials." []
synonym: "Clinical Efficacy" EXACT []
xref: NCIT:C39547
is_a: NCIT:C43646 ! Association
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C39547
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000156 xsd:string

[Term]
id: NCIT:C39796
name: Ethics
def: "The philosophical study of moral values and rules. Ethics is a general term for what is often described as the \"science of morality\". The Western tradition of ethics is sometimes called moral philosophy. This is one of the three major branches of philosophy, alongside metaphysics and logic." []
synonym: "Moral Philosophy" EXACT []
synonym: "Natural Law" EXACT []
xref: NCIT:C39796
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C39796
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004989 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0300001 xsd:string

[Term]
id: NCIT:C40438
name: Beck Depression Inventory-II (BDI-II)
def: "The BDI-II is the most widely used instrument for measuring depression. It consists of 21 items to assess the intensity of depression in clinical and normal patients. Each item is a list of four statements arranged in increasing severity about a particular symptom of depression, and rated on a scale of 0 to 3." []
synonym: "BDI-II" EXACT []
synonym: "Beck Depression Inventory" EXACT []
synonym: "Beck Depression Inventory-II" EXACT []
xref: NCIT:C40438
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
property_value: SCDO:0000340 "Beck A.T., Ward C. H., Mendelson M., Mock J., & Erbaugh J. (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic Patients" xsd:string
property_value: SCDO:0000484 "Spanish" xsd:string
property_value: SCDO:0001222 "13 years and older" xsd:string
property_value: SCDO:0001335 "yes" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000103 xsd:string

[Term]
id: NCIT:C40978
name: Telephone Number
def: "A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network." []
synonym: "Phone" EXACT []
synonym: "Phone Number" EXACT []
synonym: "Telephone" EXACT []
xref: NCIT:C40978
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 NCIT:C40978
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000881 xsd:string

[Term]
id: NCIT:C41129
name: deprecated Region
def: "An area or portion of something with more or less definite boundaries designed or specified according to some established biological, administrative, economic, demographic, etc. criteria." []
xref: NCIT:C41129
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "It didn't have sense to have this term as a sub-class of \"Major Area\", which has also been deprecated." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C41129 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006934 xsd:string
is_obsolete: true
replaced_by: SCDO:1000367

[Term]
id: NCIT:C42559
name: Degree Celsius
def: "A unit of temperature of the temperature scale designed so that the freezing point of water is 0 degrees and the boiling point is 100 degrees at standard atmospheric pressure. The current official definition of the Celsius sets 0.01 C to be at the triple point of water and a degree to be 1/273.16 of the difference in temperature between the triple point of water and absolute zero. One degree Celsius represents the same temperature difference as one Kelvin." []
synonym: "C" EXACT []
synonym: "Celsius" EXACT []
synonym: "Celsius Degree" EXACT []
synonym: "Celsius Temperature" EXACT []
synonym: "Degree C" EXACT []
synonym: "Degree Centigrade" EXACT []
synonym: "Degrees C" EXACT []
synonym: "Degrees Celsius" EXACT []
xref: NCIT:C42559
is_a: UO:0000005 ! Temperature Unit
property_value: SCDO:0000340 NCIT:C42559
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000713 xsd:string

[Term]
id: NCIT:C43646
name: Association
def: "An association is a non-hierarchical, named relationship between a source and target concept that does not affect classification and is not inherited by child concepts during classification. Associations are bidirectional and have a stated inverse. Unlike roles, associations do not have a domain or range." []
xref: NCIT:C43646
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C43646&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005031 xsd:string

[Term]
id: NCIT:C48660
name: NA
def: "Determination of a value is not relevant in the current context." []
synonym: "Not Applicable" EXACT []
xref: NCIT:C48660
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000770 xsd:string

[Term]
id: NCIT:C49131
name: Diagnostic Histology Test
def: "A diagnostic test used to examine and define microscopic tissue structure, composition, or etiology. The test results are often used by a clinician to diagnose disease or disordered function." []
synonym: "Histologic Test" EXACT []
xref: NCIT:C49131
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C49131&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004740 xsd:string

[Term]
id: NCIT:C49674
name: Breaths per Minute
def: "The number of breaths (inhalation and exhalation) taken per minute time." []
synonym: "bpm" EXACT []
synonym: "breaths/min" EXACT []
synonym: "Breaths/Minute" EXACT []
synonym: "{BREATHS}/min" EXACT []
synonym: "{breaths}/min" EXACT []
xref: NCIT:C49674
is_a: UO:0000280 ! Rate Unit
property_value: SCDO:0000340 NCIT:C49674
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000716 xsd:string

[Term]
id: NCIT:C50474
name: Bradypnea
def: "Abnormal decrease of rate of breathing." []
synonym: "Decreased Respiratory Rate" EXACT []
xref: NCIT:C50474
is_a: HP:0002086 ! Abnormality of the Respiratory System
property_value: SCDO:0000340 NCIT:C50474
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000293 xsd:string

[Term]
id: NCIT:C50767
name: Tachypnea
def: "Abnormal increase of rate of breathing." []
synonym: "Fast Breathing" EXACT []
synonym: "Increased Respiratory Rate" EXACT []
xref: NCIT:C50767
is_a: HP:0002086 ! Abnormality of the Respiratory System
property_value: SCDO:0000340 NCIT:C50767
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000347 xsd:string

[Term]
id: NCIT:C50791
name: Urinary Tract Infection
def: "A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine." []
xref: NCIT:C50791
is_a: IDO:0000586 ! Infection
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C50791 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007744 xsd:string

[Term]
id: NCIT:C51677
name: Liver Biopsy
def: "Removal of tissue from the liver for microscopic examination." []
xref: NCIT:C51677
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000303 "Use relevant object property to link to \"Elevated Hepatic Iron Concentration\"." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C51677 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000693 xsd:string

[Term]
id: NCIT:C51773
name: Married
def: "Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together." []
synonym: "Married Status" EXACT []
xref: NCIT:C51773
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 NCIT:C51773
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000674 xsd:string

[Term]
id: NCIT:C51774
name: Never Been Married
def: "Indicates a person who has never been married or whose marriages have been annulled." []
synonym: "Never Been Married/Annulled" EXACT []
synonym: "Never Married" EXACT []
synonym: "Never Married Status" EXACT []
xref: NCIT:C51774
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 NCIT:C51774
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000678 xsd:string

[Term]
id: NCIT:C51775
name: Widowed
def: "Indicates a person who is no longer married because of the death of his/her spouse and has not remarried." []
synonym: "Widowed Status" EXACT []
xref: NCIT:C51775
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 NCIT:C51775
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000675 xsd:string

[Term]
id: NCIT:C51776
name: Divorced
def: "Indicates a person whose marriage has been legally dissolved and has not remarried." []
xref: NCIT:C51776
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source NCIT:C51776
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000676 xsd:string

[Term]
id: NCIT:C519
name: Gentamicin
def: "A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses." []
synonym: "Garamicin" EXACT []
synonym: "Garamycin" EXACT []
synonym: "Genoptic" EXACT []
synonym: "Genoptic S.O.P." EXACT []
synonym: "Gentamycin" EXACT []
synonym: "Gentamycin Complex" EXACT []
synonym: "U-Gencin" EXACT []
xref: NCIT:C519
is_a: NCIT:C258 ! Antibiotic
relationship: SCDO:1000018 HP:0001081 ! treats Cholelithiasis
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C519 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001259 xsd:string

[Term]
id: NCIT:C51993
name: Antibiotic Prophylaxis
def: "Administration of antibiotics with the intent of preventing bacterial infection." []
comment: Is recommended, particularly up to the age of 5 years, to prevent bacterial infections in SCD patients.
xref: NCIT:C51993
is_a: SCDO:0000930 ! Infection Prophylaxis
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C51993 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006790 xsd:string

[Term]
id: NCIT:C52009
name: Amniocentesis
def: "A prenatal diagnostic procedure in which a small sample of amniotic fluid is removed from the uterus by a needle inserted into the abdomen. This procedure is used to detect various genetic abnormalities in the fetus and/or the sex of the fetus." []
synonym: "Amniotic Fluid Testing" EXACT []
xref: NCIT:C52009
is_a: SCDO:0000919 ! Prenatal Screening for Sickle Cell
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C52009 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000048 xsd:string

[Term]
id: NCIT:C561
name: Ibuprofen
def: "A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation." []
synonym: "2-[4-(2-methylpropyl)phenyl]propanoic acid" EXACT []
synonym: "Advil" EXACT []
synonym: "Ibuprophen" EXACT []
synonym: "Motrin" EXACT []
xref: NCIT:C561
is_a: CHEBI:35475 ! Non-Steroidal Anti-Inflammatory Drug
is_a: CHEBI:35493 ! Antipyretic
relationship: SCDO:1000018 HP:0002341 ! treats Cervical Cord Compression
relationship: SCDO:1000018 SCDO:0001056 ! treats Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/source http://www.drugbank.ca/drugs/DB01050 xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C561
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000606 xsd:string

[Term]
id: NCIT:C61797
name: Ketamine
def: "A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation." []
xref: NCIT:C61797
is_a: CHEBI:23888 ! Drug
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C61797
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000450 xsd:string

[Term]
id: NCIT:C62005
name: Amitriptyline
def: "A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity." []
xref: NCIT:C62005
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 SCDO:0000228 ! treats Chronic Neuropathic Pain
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Used to treat neuropathic pain" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C62005 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004190 xsd:string

[Term]
id: NCIT:C62198
name: Nonsense Mutation
def: "A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein." []
synonym: "Premature Termination Abnormality" EXACT []
synonym: "Premature Termination Mutation" EXACT []
xref: NCIT:C62198
is_a: NCIT:C62200 ! Point Mutation
property_value: SCDO:0000340 NCIT:C62198
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003789 xsd:string

[Term]
id: NCIT:C62200
name: Point Mutation
def: "A small scale mutation caused by the substitution of a single nucleotide for another nucleotide." []
xref: NCIT:C62200
is_a: IDOMAL:50000026 ! Mutation
relationship: SCDO:1000015 NCIT:C26548 ! modifies Gene Product
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C62200 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001372 xsd:string

[Term]
id: NCIT:C63547
name: Haplotype
def: "A way of denoting the collective genotype of a number of closely linked loci on a chromosome." []
xref: NCIT:C63547
is_a: SCDO:0004061 ! Genotype
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C63547
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007716 xsd:string

[Term]
id: NCIT:C64387
name: Millimole per Liter
def: "A unit of concentration (molarity unit) equal to one millimole of solute per liter of solution." []
synonym: "Millimolar" EXACT []
synonym: "mM" EXACT []
synonym: "mmol/L" EXACT []
xref: NCIT:C64387
is_a: UO:0000051 ! Concentration Unit
property_value: SCDO:0000340 NCIT:C64387
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000899 xsd:string

[Term]
id: NCIT:C64572
name: microgram per millilitre
def: "A metric unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one cubic meter. The concept also refers to the metric unit of mass density (volumic mass) defined as the density of a substance which mass equal to one gram occupies the volume of one cubic meter." []
synonym: "g/m3" EXACT []
synonym: "Gram per Cubic Meter" EXACT []
synonym: "gram(s)/cubic meter" EXACT []
synonym: "gram/cubic meter" EXACT []
synonym: "mcg/mL" EXACT []
synonym: "mg/dm3" EXACT []
synonym: "mg/L" EXACT []
synonym: "mg/l" EXACT []
synonym: "Microgram per Milliliter" EXACT []
synonym: "microgram per milliliter" EXACT []
synonym: "microgram per millilitre" EXACT []
synonym: "microgram(s)/millilitre" EXACT []
synonym: "Microgram/Milliliter" EXACT []
synonym: "microgram/millilitre" EXACT []
synonym: "Milligram per Cubic Decimeter" EXACT []
synonym: "Milligram per Liter" EXACT []
synonym: "milligram per liter" EXACT []
synonym: "milligram(s)/litre" EXACT []
synonym: "Nanogram per Microliter" EXACT []
synonym: "ng/uL" EXACT []
synonym: "ug/mL" EXACT []
synonym: "ug/ml" EXACT []
synonym: "µg/mL" EXACT []
xref: NCIT:C64572
is_a: UO:0000180 ! Mass Per Unit Volume
property_value: SCDO:0000340 NCIT:C64572
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000505 xsd:string

[Term]
id: NCIT:C64625
name: Pregabalin
def: "A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation." []
synonym: "3-(Aminomethyl)-5-methyl-hexanoic Acid" EXACT []
synonym: "3-Isobutyl GABA" EXACT []
synonym: "CI 1008" EXACT []
synonym: "Lyrica" EXACT []
synonym: "PD 144723" EXACT []
xref: NCIT:C64625
is_a: SCDO:0000809 ! Non Opioid
relationship: SCDO:1000018 SCDO:0000228 ! treats Chronic Neuropathic Pain
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C64625 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008454 xsd:string

[Term]
id: NCIT:C64783
name: g/dL
def: "A unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one deciliter (100 milliliters). The concept also refers to the metric unit of mass density (volumic mass) defined as the density of substance which mass equal to one gram occupies the volume one deciliter." []
synonym: "g/dl" EXACT []
synonym: "Gram per Deciliter" EXACT []
synonym: "gram per deciliter" EXACT []
synonym: "Gram/Deciliter" EXACT []
xref: NCIT:C64783
is_a: UO:0000180 ! Mass Per Unit Volume
property_value: SCDO:0000340 NCIT:C64783
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000620 xsd:string

[Term]
id: NCIT:C67015
name: mg/dL
def: "A unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters." []
synonym: "mg/dl" EXACT []
synonym: "Milligram per Deciliter" EXACT []
synonym: "Milligram/Deciliter" EXACT []
xref: NCIT:C67015
is_a: UO:0000180 ! Mass Per Unit Volume
property_value: SCDO:0000340 NCIT:C67015
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000646 xsd:string

[Term]
id: NCIT:C67244
name: thousand cells per microliter
def: "A unit of cell concentration expressed as a number of cells in thousands per unit volume equal to one microliter." []
synonym: "1000 cells/µL" EXACT []
synonym: "10^3 Cells/uL" EXACT []
synonym: "10^3{Cells}/uL" EXACT []
synonym: "10E3 Cells/uL" EXACT []
synonym: "Thousand Cells per Microliter" EXACT []
synonym: "thousand cells per microliter" EXACT []
synonym: "Thousand Cells/cu mm;" EXACT []
synonym: "thousand cells/µL" EXACT []
synonym: "thousands/µL" EXACT []
xref: NCIT:C67244
is_a: UO:0000316 ! cells per microliter
property_value: SCDO:0000340 NCIT:C67244
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000511 xsd:string

[Term]
id: NCIT:C67251
name: million cells per microliter
def: "A unit of cell concentration expressed as a number of cells in millions per unit volume equal to one microliter." []
synonym: "10^6 Cells/uL" EXACT []
synonym: "10^6{Cells}/uL" EXACT []
synonym: "10E6 cells/uL" EXACT []
synonym: "Million Cells per Microliter" EXACT []
synonym: "million cells per microliter" EXACT []
synonym: "million cells per microlitre" EXACT []
synonym: "Million Cells/cu mm" EXACT []
synonym: "million cells/µL" EXACT []
xref: NCIT:C67251
is_a: UO:0000316 ! cells per microliter
property_value: SCDO:0000340 NCIT:C67251
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000504 xsd:string

[Term]
id: NCIT:C67376
name: IU/L
def: "Unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of one international unit per one liter of the system volume." []
synonym: "IE/L" EXACT []
synonym: "International Unit per Liter" EXACT []
synonym: "International Unit per Litre" EXACT []
synonym: "International Unit/Liter" EXACT []
synonym: "International Unit/Litre" EXACT []
synonym: "Microinternational Unit per Microliter" EXACT []
synonym: "Milliinternational Unit per Milliliter" EXACT []
xref: NCIT:C67376
is_a: UO:0000051 ! Concentration Unit
property_value: SCDO:0000340 NCIT:C67376
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000658 xsd:string

[Term]
id: NCIT:C68615
name: Birth Date
def: "The calendar date on which a person was born." []
synonym: "BD" EXACT []
synonym: "Date of Birth" EXACT []
synonym: "DOB" EXACT []
xref: NCIT:C68615
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:1000537 ! Temporal Observable
property_value: SCDO:0000340 NCIT:C68615
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000544 xsd:string

[Term]
id: NCIT:C69256
name: Subject Unique Identifier
def: "A unique identifier for a subject in a study." []
comment: The unique identification of a subject in a specified context. NOTE(S): This class is a resolution of the requirement for noting the type of an identifier which is not handled by the purely technical HL7 II data type.; A unique symbol that establishes identity of the subject. EXAMPLE(S): study subject number 7 on a specific study OTHER NAME(S): NOTE(S):; Unique Identifier of patient or fetus who is the subject of observations.; The unique identification of a subject in a specified context.
synonym: "Participant ID" EXACT []
synonym: "Participant Identifier" EXACT []
synonym: "Participant Number" EXACT []
synonym: "Research Subject ID" EXACT []
synonym: "Subject ID" EXACT []
synonym: "Subject Identification Code" EXACT []
synonym: "Subject Identifier" EXACT []
synonym: "Subject UID" EXACT []
synonym: "Subject Unique Identifier" EXACT []
synonym: "Subject's Unique Identifier" EXACT []
synonym: "Subject.identifier" EXACT []
synonym: "SubjectIdentifier" EXACT []
synonym: "Unique Subject Identifier" EXACT []
synonym: "USUBJID" EXACT []
xref: NCIT:C69256
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:0300004 ! Epidemiologic Study Characteristics
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 NCIT:C69256
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000469 xsd:string

[Term]
id: NCIT:C70731
name: Clinical Trial Subject Unique Identifier
def: "A unique identifier assigned to each clinical trial subject to protect the subject's identity and used in lieu of the subject's name when the investigator reports adverse events and/or other trial-related data." []
synonym: "Clinical Study Subject Unique Identifier" EXACT []
synonym: "Clinical Trial Subject Unique Identifier" EXACT []
xref: NCIT:C70731
is_a: NCIT:C69256 ! Subject Unique Identifier
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C70731 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000002 xsd:string

[Term]
id: NCIT:C70817
name: Study Protocol
def: "The formal plan of an experiment or research activity, including the objective, rationale, design, materials and methods for the conduct of the study; intervention description, and method of data analysis." []
xref: NCIT:C70817
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C70817&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000096 xsd:string

[Term]
id: NCIT:C71375
name: Abdominal Ultrasound
def: "A method of ultrasound imaging in which the ultrasound probe is pressed against the skin of the abdomen in order to create an image of the abdominal organs." []
synonym: "Abdominal Sonogram" EXACT []
synonym: "Transabdominal Ultrasound" EXACT []
synonym: "TUS" EXACT []
xref: NCIT:C71375
is_a: NCIT:C17230 ! Ultrasound Test
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C71375
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000005 xsd:string

[Term]
id: NCIT:C71746
name: Vascular Access Device Complications
def: "Difficulties related to an apparatus used to gain access to arteries and veins." []
xref: NCIT:C71746
is_a: NCIT:C78254 ! Device Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C71746
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000389 xsd:string

[Term]
id: NCIT:C71754
name: Anonymous
def: "Having no known name or identity or known source." []
xref: NCIT:C71754
is_a: SCDO:0002125 ! Confidentiality
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C71754&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007242 xsd:string

[Term]
id: NCIT:C74096
name: Voluntary
def: "Of your own free will or design; not forced or compelled; controlled by individual volition." []
xref: NCIT:C74096
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C74096&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001874 xsd:string

[Term]
id: NCIT:C74954
name: Liver Function Test
def: "The quantitative measurement of liver enzymes in the blood, which is useful in assessing the functional state of a patient's liver. Liver function tests include the measurement of albumin, alanine transaminase, aspartate transaminase, alkaline phosphatase, bilirubin, and gamma glutamyl transferase." []
synonym: "LFT" EXACT []
synonym: "Liver Function Assay" EXACT []
synonym: "Liver Function Assays" EXACT []
synonym: "Liver Function Tests" EXACT []
xref: NCIT:C74954
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000303 "Other LFTs to be added here? There are more in NCIT" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C74954
property_value: SCDO:0000479 "PhenX protocol: Liver Function - Assay #190801" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000695 xsd:string

[Term]
id: NCIT:C75434
name: Hemoglobin Subunit Alpha
def: "Hemoglobin subunit alpha (142 aa, ~15 kDa) is encoded by both the human HBA1 and human HBA2 genes. This protein plays a role in the distribution of oxygen from the lungs to other organs and tissues." []
synonym: "Alpha Globin" EXACT []
synonym: "Alpha-Globin" EXACT []
synonym: "Alpha-Globin Chain" EXACT []
synonym: "Haemoglobin Alpha Chain" EXACT []
synonym: "Haemoglobin Subunit Alpha" EXACT []
synonym: "Hemoglobin Alpha Chain" EXACT []
synonym: "Hemoglobin Subunit Alpha" EXACT []
xref: NCIT:C75434
is_a: SCDO:1000105 ! Alpha-Globin Family Members
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C75434
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000365 xsd:string

[Term]
id: NCIT:C75583
name: Slit-Lamp Examination
def: "Examination of the anterior segment of the eye using a medical instrument called a slit lamp." []
synonym: "SLIT LAMP" EXACT []
synonym: "Slit-Lamp Biomicroscopy" EXACT []
synonym: "Slit-Lamp Eye Exam" EXACT []
xref: NCIT:C75583
is_a: NCIT:C38060 ! Eye Examination
relationship: SCDO:1000192 SCDO:0001077 ! uses diagnostic device Slit Lamp
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C75583 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001078 xsd:string

[Term]
id: NCIT:C78254
name: Device Complication
def: "Any problem arising from the use of a medical device." []
xref: NCIT:C78254
is_a: NCIT:C2959 ! Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C78254
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000385 xsd:string

[Term]
id: NCIT:C78393
name: Iron Overload
def: "Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death." []
synonym: "Diabetes Bronze" EXACT []
synonym: "Haemochromatosis" EXACT []
synonym: "Hemochromatosis" EXACT []
synonym: "Iron Storage Disorder" EXACT []
xref: NCIT:C78393
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Perhaps suggest that NCIT merges this term with \"Hemochromatosis\", which they have as a separate term. \n\nSub-classes need to be worked on further. Consider sub-classes of \"hemochromatosis\" in the DO.\n\nInclude Hemosiderosis as a sub-class?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C78393 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001945 xsd:string

[Term]
id: NCIT:C78598
name: Posterior Reversible Leukoencephalopathy
def: "An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment." []
synonym: "Reversible Posterior Leukoencephalopathy Syndrome" EXACT []
xref: NCIT:C78598
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C78598 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007836 xsd:string

[Term]
id: NCIT:C78638
name: Thrombus in Catheter
def: "The development of a blood clot in a catheter." []
xref: NCIT:C78638
is_a: NCIT:C78254 ! Device Complication
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C78638
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000388 xsd:string

[Term]
id: NCIT:C78652
name: Pediatric Quality of Life Inventory (PedsQL)
def: "A parent report or patient self report for measuring health-related quality of life (HRQOL) in healthy children and adolescents and those with acute and chronic health conditions. The PedsQL Measurement Model uses a modular approach that integrates both generic core scales and disease-specific modules into one measurement system. (Copyright 1998-2008 James W. Varni, Ph.D.)" []
synonym: "Pediatric Quality of Life Inventory" EXACT []
synonym: "PedsQL" EXACT []
xref: NCIT:C78652
is_a: SCDO:0000952 ! Quality of Life in Sickle Cell Disease Measure
property_value: http://purl.org/dc/elements/1.1/source "Varni, J. W., Seid, M., and Kurtin, P. S. (2001). PedsQL 4.0: Reliability and validity of the 86 pediatric quality of life inventory version 4.0 generic core scales in healthy and patient populations. Medical Care, 39, 800-812." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C78652
property_value: SCDO:0000481 "Self; Proxy (Parent report)" xsd:string
property_value: SCDO:0000482 "Clinic patients" xsd:string
property_value: SCDO:0000484 "Many measures available in Spanish, French and Portuguese" xsd:string
property_value: SCDO:0001222 "Toddlers; Children; Adolescents" xsd:string
property_value: SCDO:0001335 "yes" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000875 xsd:string

[Term]
id: NCIT:C79903
name: Blood Smear
def: "A sample of blood applied in a thin film to a microscope slide for study under a microscope." []
xref: NCIT:C79903
is_a: SCDO:0000133 ! Blood Test
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C79903
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0008915 xsd:string

[Term]
id: NCIT:C80411
name: Right Heart Catheterization
def: "A diagnostic procedure in which a catheter is guided into the right heart, where pressures may be measured and radiocontrast material may be injected to visualize blood flow in and around the right heart." []
synonym: "Pulmonary Artery Catheterization" EXACT []
synonym: "Swan-Ganz Catheterization" EXACT []
xref: NCIT:C80411
is_a: SCDO:0000500 ! Heart Function Test
relationship: SCDO:1000192 SCDO:0000190 ! uses diagnostic device Catheter
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C80411 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001012 xsd:string

[Term]
id: NCIT:C81229
name: Alcohol Use History
def: "A description of an individual's current and past experience with alcoholic beverage consumption." []
xref: NCIT:C81229
is_a: SCDO:0001120 ! Substance Use History
property_value: SCDO:0000303 "Add other terms in the PhenX \"Alcohol Use\" collection?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C81229 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000040 xsd:string

[Term]
id: NCIT:C81262
name: Medical Record Number
def: "An identifying number within an institution that is used to reference a subject's medical information." []
xref: NCIT:C81262
is_a: NCIT:C69256 ! Subject Unique Identifier
property_value: SCDO:0000340 "C81262"
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000853 xsd:string

[Term]
id: NCIT:C82909
name: Mild Anemia
def: "Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%." []
xref: NCIT:C82909
is_a: HP:0001903 ! Anemia
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C82909 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003672 xsd:string

[Term]
id: NCIT:C83031
name: Visit Date
def: "The date on which a visit occurred." []
synonym: "Clinical Visit Date" EXACT []
xref: NCIT:C83031
is_a: EUPATH:0000310 ! Information on Observation Details
is_a: SCDO:1000537 ! Temporal Observable
property_value: SCDO:0000340 NCIT:C83031
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000540 xsd:string

[Term]
id: NCIT:C84481
name: Hereditary Hemochromatosis
def: "An inherited metabolic disorder characterized by iron accumulation in the tissues." []
synonym: "Congenital Haemochromatosis" EXACT []
synonym: "Hereditary Haemochromatosis" EXACT []
synonym: "Iron Overload Disease" EXACT []
synonym: "Primary Haemochromatosis" EXACT []
xref: NCIT:C84481
is_a: NCIT:C78393 ! Iron Overload
property_value: SCDO:0000340 NCIT:C84481
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000512 xsd:string

[Term]
id: NCIT:C84979
name: Hemoglobin Subunit Epsilon
def: "Hemoglobin subunit epsilon (147 aa, ~16 kDa) is encoded by the human HBE1 gene. This protein plays a role in the transport of oxygen to tissues of the embryo." []
synonym: "Epsilon-Globin" EXACT []
synonym: "Haemoglobin Epsilon Chain" EXACT []
synonym: "Haemoglobin Subunit Epsilon" EXACT []
synonym: "Hemoglobin Epsilon Chain" EXACT []
xref: NCIT:C84979
is_a: SCDO:1000012 ! Beta-Globin Family Members
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C84979 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001381 xsd:string

[Term]
id: NCIT:C84980
name: Hemoglobin Subunit Delta
def: "A type of polypeptide chain that when in combination with alpha globin polypeptide chains forms adult hemoglobin 2 (HbA2). HbA2 comprises around 3% of adult hemoglobin. Hemoglobin subunit delta (147 aa, ~16 kDa) is encoded by the human HBD gene. This protein plays a role in the transport of oxygen to tissues of the adult body." []
synonym: "Delta Globin" EXACT []
synonym: "Delta-Globin" EXACT []
synonym: "Haemoglobin Delta Chain" EXACT []
synonym: "Haemoglobin Subunit Delta" EXACT []
synonym: "Hemoglobin Delta Chain" EXACT []
xref: NCIT:C84980
is_a: SCDO:1000012 ! Beta-Globin Family Members
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C84980 xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/gene/3045 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000011 xsd:string

[Term]
id: NCIT:C84983
name: Hemoglobin Subunit Beta
def: "Hemoglobin subunit beta (147 aa, ~16 kDa) is encoded by the human HBB gene. This protein plays a role in the transport of oxygen to tissues of the adult body." []
synonym: "Beta Globin" EXACT []
synonym: "Beta Globin Chain" EXACT []
synonym: "Beta-Globin" EXACT []
synonym: "Beta-Globin Chain" EXACT []
synonym: "Haemoglobin Beta Chain" EXACT []
synonym: "Haemoglobin Subunit Beta" EXACT []
synonym: "HBB" EXACT []
synonym: "Hemoglobin Beta Chain" EXACT []
xref: NCIT:C84983
is_a: SCDO:1000012 ! Beta-Globin Family Members
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C84983
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000358 xsd:string

[Term]
id: NCIT:C85397
name: Spirometry
def: "Measurement of the breathing capacity of the lung by means of a spirometer." []
xref: NCIT:C85397
is_a: SCDO:0000942 ! Pulmonary Function Test
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000192 SCDO:0001099 ! uses diagnostic device Spirometer
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C85397
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001100 xsd:string

[Term]
id: NCIT:C86008
name: Methemoglobin
def: "A product of hemoglobin produced by oxidation of the iron atom from the ferrous to the ferric state." []
synonym: "MetHb" EXACT []
xref: NCIT:C86008
is_a: NCIT:C16676 ! Hemoglobin
property_value: SCDO:0000340 NCIT:C86008
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000167 xsd:string

[Term]
id: NCIT:C91105
name: Clinical or Research Assessment Questionnaire
def: "An instrument consisting of a predetermined set of questions for a clinical or research assessment." []
xref: NCIT:C91105
is_a: SCDO:1000472 ! Data Standards
property_value: SCDO:0000340 NCIT:C91105
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000476 xsd:string

[Term]
id: NCIT:C91106
name: Clinical or Research Assessment Answer
def: "A statement (either spoken or written) that is made in reply to a clinical research assessment question." []
synonym: "Clinical or Research Assessment Response" EXACT []
xref: NCIT:C91106
is_a: SCDO:1000472 ! Data Standards
property_value: SCDO:0000340 NCIT:C91106
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000473 xsd:string

[Term]
id: NCIT:C92755
name: Chorionic Villus Sampling
def: "The biopsy of placental tissue containing the chorionic villi from the maternal uterus in early pregnancy to diagnose fetal genetic defects." []
synonym: "CVS" EXACT []
xref: NCIT:C92755
is_a: SCDO:0000919 ! Prenatal Screening for Sickle Cell
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C92755 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000223 xsd:string

[Term]
id: NCIT:C92803
name: Genetic Screening
def: "Testing to determine if there is a predisposition or indication of a possible genetic or a chromosomal abnormality." []
xref: NCIT:C92803
is_a: NCIT:C15709 ! Genetic Testing
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C92803 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000446 xsd:string

[Term]
id: NCIT:C92853
name: Postpartum Hemorrhage
def: "Hemorrhage defined as a blood loss in excess of 500 mL after vaginal delivery or more than 1000 mL after a cesarean delivery." []
xref: NCIT:C92853
is_a: HP:0001197 ! Abnormality of Prenatal Development or Birth
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
is_a: NCIT:C34941 ! Pregnancy Complication
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C92853
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000916 xsd:string

[Term]
id: NCIT:C93407
name: Study Outcome Measurement
def: "Specific key measurement(s) or observation(s) used to measure the effect of experimental variables on the subjects in a study, or for observational studies, to describe patterns of diseases or traits or associations with exposures, risk factors or treatment. The specific measure that receives the most emphasis in assessment." []
synonym: "Study Outcome Measure" EXACT []
xref: NCIT:C93407
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C93407 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001116 xsd:string

[Term]
id: NCIT:C95437
name: Acute Pancreatitis
def: "An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs." []
xref: NCIT:C95437
is_a: HP:0025031 ! Abnormality of the Digestive System
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C95437 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005115 xsd:string

[Term]
id: NCIT:C95504
name: Hemoglobin H Disease
def: "A form of alpha thalassemia that results from reduced protein production from three of the four alpha-globin genes. Clinically it is characterized by chronic hemolytic anemia." []
synonym: "Alpha-Thalassemia Intermedia" EXACT []
synonym: "Haemoglobin H Disease" EXACT []
synonym: "Hb H-Disease" EXACT []
xref: NCIT:C95504
is_a: SCDO:0000042 ! Alpha Thalassemia
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0000663 SCDO:0003894 ! diagnosed using tool Gap PCR
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0008888 ! treated with Iron Chelation Therapy
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000005 SCDO:0000114 ! modified by Beta Thalassemia Trait
relationship: SCDO:1000172 EUPATH:0000034 ! has causal genotype Alpha Thalassemia Genotype
relationship: SCDO:1000218 HP:0004870 ! has manifestation Chronic Hemolytic Anemia
relationship: SCDO:1000223 SCDO:0001384 ! has causal molecular phenotype Reduced Alpha/Gamma Synthesis Ratio
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95504 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000534 xsd:string

[Term]
id: NCIT:C95534
name: Hemoglobin Trait
def: "A condition in which a person is heterozygous for a globin gene, with one normal allele and one defective allele." []
synonym: "Heterozygous Hemoglobinopathy" EXACT []
xref: NCIT:C95534
is_a: SCDO:0000552 ! Hemoglobinopathy
property_value: SCDO:0000303 "NCIT includes this class below \"Hemoglobinopathy\", hence its inclusion here." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95534 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000550 xsd:string

[Term]
id: NCIT:C95535
name: Alpha Thalassemia Trait
def: "A condition in which a person has reduced protein production from two of the four alpha-globin alleles." []
comment: -/- alpha/alpha or -/alpha -/alpha. It can exist in two forms: (1) alpha-thal-1 (alpha alpha/--), involves cis deletion of both alpha genes on the same chromosome; (2) alpha-thal-2 (alpha-/alpha-), involves trans deletion of alpha genes this occurs on different (homologous) chromosomes.
synonym: "Alpha-Thalassemia Trait" EXACT []
xref: NCIT:C95535
is_a: SCDO:0000551 ! Thalassemia Trait
relationship: SCDO:1000015 SCDO:0000251 ! modifies Clinical Phenotype of Beta Thalassemia
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
relationship: SCDO:1000172 EUPATH:0000034 ! has causal genotype Alpha Thalassemia Genotype
relationship: SCDO:1000210 SCDO:0001386 ! has causal or contributing genetic variation Alpha-Globin Locus Deletion
relationship: SCDO:1000218 NCIT:C3833 ! has manifestation Asymptomatic
property_value: http://purl.org/dc/elements/1.1/source Alpha:Thalassemia
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95535 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000044 xsd:string

[Term]
id: NCIT:C95536
name: Alpha Thalassemia Silent Carrier
def: "A condition in which a person has reduced protein production from one of the four alpha-globin alleles." []
synonym: "Alpha Thalassemia Silent" EXACT []
synonym: "Alpha-Thalassemia Silent Carrier" EXACT []
xref: NCIT:C95536
is_a: SCDO:0000551 ! Thalassemia Trait
relationship: SCDO:1000172 EUPATH:0000034 ! has causal genotype Alpha Thalassemia Genotype
relationship: SCDO:1000210 SCDO:0001386 ! has causal or contributing genetic variation Alpha-Globin Locus Deletion
relationship: SCDO:1000218 NCIT:C3833 ! has manifestation Asymptomatic
property_value: http://purl.org/dc/elements/1.1/source Alpha:Thalassemia
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C95536 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000043 xsd:string

[Term]
id: NCIT:C95539
name: Sickle Beta Thalassemia
def: "A compound heterozygous state in which a person has a hemoglobin S allele along with a beta-thalassemia allele. The severity of the condition is determined to a large extent by the quantity of normal hemoglobin produced by the beta-thalassemia gene." []
synonym: "Hb S-Beta Thalassemia" EXACT []
synonym: "HbS-Beta-Thalassemia Syndrome" EXACT []
synonym: "HbSBetaThal" EXACT []
synonym: "S Beta-Thalassemia" EXACT []
synonym: "S-Beta Thalassemia" EXACT []
synonym: "Sickle Beta Thalassaemia" EXACT []
synonym: "Sickle Beta-Thalassaemia" EXACT []
synonym: "Sickle Cell Beta Thalassemia Disease" EXACT []
synonym: "Sickle Cell Disease-S Beta Thalassaemia" EXACT []
synonym: "Sickle Cell-Beta Thalassaemia" EXACT []
synonym: "Sickle Cell-Beta-Thalassemia" EXACT []
synonym: "Sickle Cell-Beta-Thalassemia Disease Syndrome" EXACT []
xref: NCIT:C95539
is_a: SCDO:0007656 ! Sickle Cell Thalassemia
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000107 ! has causal genotype Hemoglobin Genotype S/Beta Thalassemia
relationship: SCDO:1000210 SCDO:0009731 ! has causal or contributing genetic variation Beta Thalassemia Mutation
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000223 HP:0011906 ! has causal molecular phenotype Reduced Beta/Alpha Synthesis Ratio
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000240 ! has causal molecular phenotype Reduced or Absent Hemoglobin A
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C61237
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001057 xsd:string

[Term]
id: NCIT:C96239
name: Glomerular Hypertrophy
def: "A morphologic finding indicating enlargement of the glomeruli in a kidney specimen." []
xref: NCIT:C96239
is_a: HP:0000077 ! Abnormality of the Kidney
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C96239
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002784 xsd:string

[Term]
id: NCIT:C96391
name: Meningococcal Conjugate Vaccine MCV4
def: "A conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135." []
synonym: "MCV4" EXACT []
synonym: "Menactra" EXACT []
synonym: "Meningococcal Conjugate Vaccine MCV-4" EXACT []
synonym: "Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugated Vaccine" EXACT []
synonym: "Menveo" EXACT []
xref: NCIT:C96391
is_a: VO:0000001 ! Vaccine
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C96391 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006120 xsd:string

[Term]
id: NCIT:C97120
name: Pneumococcal 10-Valent Conjugate Vaccine
def: "An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It is indicated for disease caused by serotypes 1, 5, 4, 6B, 7, 9V, 14, 18C, 19F, and 23F." []
synonym: "PCV 10" EXACT []
xref: NCIT:C97120
is_a: NCIT:C97123 ! Conjugate Pneumococcal Vaccine
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C97120 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000909 xsd:string

[Term]
id: NCIT:C97121
name: Pneumococcal 13-Valent Conjugate Vaccine
def: "A pneumococcal conjugate vaccine containing 13 different strains of the bacterium Streptococcus pneumoniae, used in children and studied in immunocompromised patients for the prevention of pneumococcal disease. The pneumococcal 13-valent conjugate vaccine contains capsular antigen polysaccharides derived from the S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F that are individually conjugated to a nontoxic diphtheria cross-reactive material (CRM) carrier protein (CRM197). Upon vaccination, pneumococcal 13-valent conjugate vaccine induces active immunization against 13 different serotypes of S. pneumoniae and protects against pneumococcal disease." []
synonym: "PCV 13" EXACT []
synonym: "PCV13 Vaccine" EXACT []
synonym: "Prevnar 13" EXACT []
xref: NCIT:C97121
is_a: NCIT:C97123 ! Conjugate Pneumococcal Vaccine
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C97121 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000910 xsd:string

[Term]
id: NCIT:C97123
name: Conjugate Pneumococcal Vaccine
def: "An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes individually conjugated to proteins." []
synonym: "Pneumococcal Conjugate Vaccine" EXACT []
xref: NCIT:C97123
is_a: VO:0000675 ! Streptococcus Pneumoniae Vaccine
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C97123 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000275 xsd:string

[Term]
id: NCIT:C98805
name: Acquired Methemoglobinemia
def: "Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods." []
xref: NCIT:C98805
is_a: SCDO:0000753 ! Methemoglobinemia
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98805&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000013 xsd:string

[Term]
id: NCIT:C98835
name: Sickle Cell Disease-S Beta Zero Thalassemia
def: "A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease." []
synonym: "Hb S Beta 0 Thalassemia" EXACT []
synonym: "Hemoglobin S Beta 0 Thalassemia" EXACT []
synonym: "S Beta 0 Thalassemia" EXACT []
synonym: "S beta-zero" EXACT []
synonym: "Sickle Beta 0 Thalassemia" EXACT []
synonym: "Sickle Beta Zero Thalassemia" EXACT []
synonym: "Sickle Cell-Beta 0 Thalassemia" EXACT []
synonym: "Sickle Cell-Beta Zero Thalassemia" EXACT []
xref: NCIT:C98835
is_a: NCIT:C95539 ! Sickle Beta Thalassemia
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000067 ! has causal genotype Hemoglobin Genotype S/Beta Zero Thalassaemia
relationship: SCDO:1000218 EUPATH:0000215 ! has manifestation Severe Anemia
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000241 ! has causal molecular phenotype Absent Hemoglobin A
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "Requires further refinement." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98835 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001058 xsd:string

[Term]
id: NCIT:C99042
name: Renal Vein Thrombosis
def: "The formation of a thrombus in the renal vein." []
xref: NCIT:C99042
is_a: HP:0000077 ! Abnormality of the Kidney
is_a: HP:0001977 ! Abnormal Thrombosis
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C99042 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005061 xsd:string

[Term]
id: NCIT:C99063
name: Spinal Cord Infarction
def: "Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence." []
xref: NCIT:C99063
is_a: HP:0012639 ! Abnormal Nervous System Morphology
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Can be treated with exchange transfusion (SCDO:0001303)" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C99063 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005226 xsd:string

[Term]
id: OBI:0000185
name: Imaging Assay
def: "An assay that produces a picture of an entity." []
xref: OBI:0000185
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000303 "Perhaps replace this term with \"Diagnostic Imaging\" from NCIT?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OBI_0000185 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000612 xsd:string

[Term]
id: OBI:0000626
name: DNA Sequencing
def: "A sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument." []
xref: OBI:0000626
is_a: SCDO:0000448 ! Genetic Technique
property_value: SCDO:0000303 "Add sub-class \"beta-globin gene sequencing\" as per the \"Diagnostic Methods\" section of the term \"Dominant beta-thalassemia\" in Orphanet." xsd:string
property_value: SCDO:0000340 OBI:0000626
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004249 xsd:string

[Term]
id: OBI:0000925
name: Infectious Agent
def: "A material entity bearing the disposition to infect an organism" []
xref: OBI:0000925
is_a: SCDO:0000435 ! Environmental Disease Modifier
property_value: SCDO:0000340 OBI:0000925
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000638 xsd:string

[Term]
id: OBI:0000990
name: Electron Microscope
def: "A microscope that produces an image of an object by targeting it with an electron beam." []
comment: It is capable of much higher magnifications and has a greater resolving power than a light microscope, allowing it to see much smaller objects in finer detail.
xref: OBI:0000990
is_a: OBI:0400169 ! Microscope
property_value: SCDO:0000340 OBI:0000990
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000422 xsd:string

[Term]
id: OBI:0001098
name: Ultrasound Machine
def: "A device that is used to visualize subcutaneous body structures including tendons, muscles, joints, vessels and internal organs." []
xref: OBI:0001098
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 NCIT:C17230 ! used by diagnostic tool Ultrasound Test
property_value: SCDO:0000340 OBI:0001098
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001202 xsd:string

[Term]
id: OBI:0001138
name: X-Ray Machine
def: "A device that is used to generate X-rays." []
synonym: "Radiographic Unit" EXACT []
xref: OBI:0001138
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 SCDO:0000217 ! used by diagnostic tool Chest X-Ray
relationship: SCDO:1000191 SCDO:0000963 ! used by diagnostic tool Radiography
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OBI_0001138 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001251 xsd:string

[Term]
id: OBI:0002140
name: Temperature Measurement Assay
def: "An assay to determine the temperature of an evaluant." []
xref: OBI:0002140
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000340 OBI:0002140
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000752 xsd:string

[Term]
id: OBI:0002146
name: HIV Antibody Test
def: "An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) antigens." []
comment: The window period for antibody tests in most people is somewhere between 3 to 12 weeks from the time of infection.
synonym: "HIV Antibody Assay" EXACT []
xref: OBI:0002146
is_a: SCDO:0000571 ! HIV Test
property_value: http://purl.org/dc/elements/1.1/source https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/19/47/hiv-testing
property_value: SCDO:0000340 OBI:0002146
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000195 xsd:string

[Term]
id: OBI:0002556
name: Minimum Age Value Specification
def: "A value specifcation that specifies the youngest age when specifying an age range." []
xref: OBI:0002556
is_a: SCDO:1000401 ! Data Descriptor
property_value: SCDO:0000340 OBI:0002556
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000405 xsd:string

[Term]
id: OBI:0002557
name: Maximum Age Value Specification
def: "A value specifcation that specifies the oldest age when specifying an age range." []
xref: OBI:0002557
is_a: SCDO:1000401 ! Data Descriptor
property_value: SCDO:0000340 OBI:0002557
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000404 xsd:string

[Term]
id: OBI:0200198
name: Tandem Mass Spectrometry
def: "A data transformation that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules)." []
comment: Example of usage: A precursor ion is selected in the first stage, allowed to fragment and then all resultant masses are scanned in the second mass analyzer and detected in the detector that is positioned after the second mass analyzer. This experiment is commonly performed to identify transitions used for quantification by tandem MS.
synonym: "MS/MS" EXACT []
synonym: "Tandem MS" EXACT []
xref: OBI:0200198
is_a: SCDO:0000216 ! Chemical Assay
property_value: http://purl.org/dc/elements/1.1/source OBI:0200198
property_value: SCDO:0000340 OBI:0200198
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001138 xsd:string

[Term]
id: OBI:0400115
name: Spectrophotometer
def: "A spectrophotometer is an instrument that measures the intensity of light as a function of the color, or more specifically, the wavelength of light, transmitted by a substance." []
xref: OBI:0400115
is_a: SCDO:0000376 ! Diagnostic Device
property_value: SCDO:0000340 OBI:0400115
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001096 xsd:string

[Term]
id: OBI:0400169
name: Microscope
def: "A microscope is an instrument which magnifies the view on objects (too small to be viewed by the naked eye) under increased resolution. A microscope can be an optical instrument but also and electronic instrument. There are various kind of optical microscopes, e.g confocal microscope, epifluoresence microscope)." []
xref: OBI:0400169
is_a: SCDO:0000376 ! Diagnostic Device
property_value: SCDO:0000340 OBI:0400169
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000757 xsd:string

[Term]
id: OBI:1110053
name: Cancer
def: "A disease characterized by abnormal and uncontrolled cell division." []
synonym: "Malignancy" EXACT []
synonym: "Malignant Neoplasia" EXACT []
synonym: "Malignant Neoplasm" EXACT []
synonym: "Malignant Tumor" EXACT []
synonym: "Malignant Tumour" EXACT []
xref: OBI:1110053
is_a: SCDO:0000267 ! Comorbid Disease
relationship: SCDO:0000664 SCDO:0001252 ! treated with X-Ray Therapy
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OBI_1110053 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000180 xsd:string

[Term]
id: OGMS:0000023
name: Phenotype
def: "A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species." []
xref: OGMS:0000023
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000303 "Sub-classes to be added?:  -- increased lactate dehydrogenase level (in Ontology of Adverse Events AOE) -- decreased lactate dehydrogenase level (Mammalian Phenotype Ontology) -- Splenomegaly (link this to Spleen Examination) -- Obstructive Hydrocephalus (see \"Cerebellar Hemorrhage\") -- Failure to Thrive (MeSH) -- Cardiac Output, Low (MeSH) -- Cardiac Output, High (MeSH) --\nAdd the sub-class \"Clinical Phenotype\" from Ontology for General Medical Science" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/OGMS?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FOGMS_0000023 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000893 xsd:string

[Term]
id: OGMS:0000028
name: Disease Phenotype
def: "A clinically abnormal phenotype that is characteristic of a single disease." []
xref: OGMS:0000028
is_a: OGMS:0000023 ! Phenotype
property_value: SCDO:0000340 OGMS:0000028
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000185 xsd:string

[Term]
id: OGMS:0000046
name: Epigenetic Disorder
def: "A disorder whose etiology involves (1) a modification to the patient's genomic DNA which leads to alterations in the normal expression pattern of the genome, but is (2) not a change in the nucleotide sequence." []
synonym: "Epigenomic Disorder" EXACT []
xref: OGMS:0000046
is_a: SCDO:0000444 ! Genetic Disease Modifier
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OGMS_0000046 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000439 xsd:string

[Term]
id: OGMS:0000047
name: Genetic Disorder
def: "A disorder whose etiology involves an abnormality in the nucleotide sequence of an organism's genome." []
xref: OGMS:0000047
is_a: DOID:4 ! Disease
is_a: SCDO:0000444 ! Genetic Disease Modifier
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OGMS_0000047 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000445 xsd:string

[Term]
id: OGMS:0000051
name: Constitutional Genetic Disorder
def: "A genetic disorder inherited during conception that is part of all cells in the organism." []
xref: OGMS:0000051
is_a: OGMS:0000047 ! Genetic Disorder
property_value: SCDO:0000303 "Perhaps remove this class but keep sub-classes? Or include the class \"Acquired Genetic Disorder\" as a sibling of this class if terms are included that can be sub-classes of it?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OGMS_0000051 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000279 xsd:string

[Term]
id: OGMS:0000088
name: Patient Symptom Report
def: "A communication from a patient about something they perceive as being abnormal about their body or life." []
xref: OGMS:0000088
is_a: SCDO:0000738 ! Medical Records
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OGMS_0000088 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000872 xsd:string

[Term]
id: OPMI:0000023
name: Yes
def: "An answer to question where the answer is Yes." []
synonym: "yes answer to question" EXACT []
xref: OPMI:0000023
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 OPMI:0000023
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000563 xsd:string

[Term]
id: OPMI:0000024
name: No
def: "An answer to question where the answer is No." []
synonym: "no answer to question" EXACT []
xref: OPMI:0000024
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 OPMI:0000024
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000564 xsd:string

[Term]
id: OPMI:0000025
name: Do Not Know
def: "An answer to question that indicates the response to the specified question is unknown." []
synonym: "Don't know" EXACT []
synonym: "unknown answer to question" EXACT []
xref: OPMI:0000025
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 OPMI:0000025
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000562 xsd:string

[Term]
id: OPMI:0000027
name: Refused
def: "An answer to question where one declines to answer the specified question." []
synonym: "declined to answer question" EXACT []
synonym: "declined to answer to question" EXACT []
synonym: "Refuse to answer" EXACT []
synonym: "Refused to answer" EXACT []
xref: OPMI:0000027
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 OPMI:0000027
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000561 xsd:string

[Term]
id: OPMI:0000028
name: Other
def: "An answer to question that is not enumerated in the list and then may be entered with free text in a separate text box" []
synonym: "other answer to question" EXACT []
xref: OPMI:0000028
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: SCDO:0000340 OPMI:0000028
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000565 xsd:string

[Term]
id: PR:000001318
name: L-Selectin
def: "A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes." []
comment: L-selection is a serum marker for neutrophil activation.
synonym: "CD62 Antigen-Like Family Member L" EXACT []
synonym: "CD62L" EXACT []
synonym: "Lymph Node Homing Receptor" EXACT []
xref: PR:000001318
is_a: NCIT:C26548 ! Gene Product
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543649/
property_value: SCDO:0000340 PR:000001318
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000443 xsd:string

[Term]
id: SBO:0000316
name: MicroRNA
def: "Single-stranded RNA molecules thought to regulate the expression of other genes. miRNAs are encoded by genes that are transcribed from DNA but not translated into protein (non-coding RNA)." []
synonym: "miRNA" EXACT []
xref: SBO:0000316
is_a: NCIT:C26548 ! Gene Product
property_value: SCDO:0000340 SBO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FSBO:0000316
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000756 xsd:string

[Term]
id: SCDO:0000006
name: Ability to Carry Out Activities of Daily Living
def: "The performance of the basic activities of self care, such as dressing, ambulation, or eating." []
synonym: "ADL" EXACT []
synonym: "Daily Living Activities" EXACT []
synonym: "Daily Living Activity" EXACT []
synonym: "Self Care (Rehabilitation)" EXACT []
synonym: "Self-Care" EXACT []
xref: MESH:D000203
is_a: SCDO:0000900 ! Physical Functioning
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000203 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000006 xsd:string

[Term]
id: SCDO:0000007
name: Abnormal Hemoglobin in SCD
def: "A structurally abnormal hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD)." []
synonym: "Structurally Abnormal Hemoglobin Present in SCD" EXACT []
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
is_a: SCDO:1000060 ! SCD Molecular Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably too specific to SCD be included in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000008
name: deprecated Abnormality of Erythrocytes
def: "Abnormality in structure and function of the Red Blood Cell." []
synonym: "Abnormality of Red Blood Cell" EXACT []
synonym: "Abnormality of Red Blood Cells" EXACT []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "Are there other relevant erythrocyte abnormalities that can be included as children here? If not, this class can be removed and just keep \"Abnormal Hemoglobin\"." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001877 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
is_obsolete: true

[Term]
id: SCDO:0000010
name: Acetaminophen
def: "Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage." []
synonym: "Paracetamol" EXACT []
synonym: "Tylenol" EXACT []
xref: MESH:D000082
is_a: CHEBI:35493 ! Antipyretic
is_a: SCDO:0000809 ! Non Opioid
relationship: SCDO:1000018 SCDO:0001056 ! treats Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000082
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000010 xsd:string

[Term]
id: SCDO:0000016
name: Acute Complications of Sickle Cell Disease
def: "A condition that co-exists or follows from sickle cell disease and that has a severe and rapid onset of symptoms with short duration." []
synonym: "Acute Complications of SCD" EXACT []
is_a: NCIT:C2959 ! Complication
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C14140 xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/Q000150 xsd:string
property_value: SCDO:0000303 "Probably too specific to warrant inclusion into anther ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000018
name: Acute Non-Specific Wheezing Episode
def: "An acute onset of wheezing in a person with SCD who has no co-morbid asthma." []
comment: Too specific to SCD to be included in other ontologies?\n\nPFTs may be done to asses for airway hyper-responsiveness.
is_a: HP:0002086 ! Abnormality of the Respiratory System
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000663 SCDO:0000942 ! diagnosed using tool Pulmonary Function Test
property_value: http://purl.org/dc/elements/1.1/source "Cohen et al 2011 Am J Hematol., Glassberg et al 2014 Curr Opin Pediatr., Knight-Madden et al 2014 Ped Resp Rev" xsd:string
property_value: SCDO:0000303 "Check and show which source was used for the description and whether the description was adapted from the source. -- Provide source for additional info." xsd:string
property_value: SCDO:0000340 "Cohen et al 2011 Am J Hematol., Glassberg et al 2014 Curr Opin Pediatr., Knight-Madden et al 2014 Ped Resp Rev" xsd:string
property_value: SCDO:0000661 "Etiology may be unclear.  May be related to inflammation of SCD and/or viral lower respiratory tract infection." xsd:string
property_value: SCDO:0000662 "Normal Chest X-ray" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000019
name: Acute Sickle Cell Pain Management
def: "Sickle cell pain management that aims to heal the acute process." []
synonym: "Acute Sickle Cell Pain Treatment" EXACT []
is_a: SCDO:0001052 ! Sickle Cell Pain Management
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into MESH below \"Pain Management\" / \"Sickle Cell Pain Management\" (also to be suggested for inclusion)" xsd:string
property_value: SCDO:0000340 SCDO:1000152
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000021
name: Acute Upper Respiratory Tract Infection
def: "An acute respiratory illness with no lower respiratory tract signs or infiiltrate on chest radiograph." []
synonym: "Acute Upper Respiratory Infection" EXACT []
synonym: "URI" EXACT []
synonym: "URTI" EXACT []
is_a: IDO:0000586 ! Infection
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000217 ! diagnosed using tool Chest X-Ray
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 SCDO:0001133 ! treated with Symptomatic Therapeutics
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000024
name: deprecated-Adherence
def: "The extent to which a person's behaviour - taking medications, following a diet and/or executing life style changes, corresponds to agreed recommendations by a health care provider." []
synonym: "Adherence to Long Term Therapy" EXACT []
synonym: "Patient Adherence" EXACT []
synonym: "Patient Compliance" EXACT []
synonym: "Patient Cooperation" EXACT []
xref: MESH:D010349
is_a: SCDO:0000359 ! deprecated terms
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/D010349
property_value: SCDO:0000303 "Suggest update to description for \"Patient Compliance\" in MESH." xsd:string
property_value: SCDO:0000340 http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf
property_value: SCDO:1000288 "Suggest update to description" xsd:string
is_obsolete: true
replaced_by: SCDO:0000869

[Term]
id: SCDO:0000026
name: Adult Migraine Questionnaire
def: "A 20-item questionnaire that assesses the frequency of severe headaches, the level of pain, whether the person is taking medications, and associated complications such as nausea." []
xref: phenX:130501
is_a: SCDO:0000760 ! Migraine Questionnaire
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Migraine - Adult\") as we have done." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/130501
property_value: SCDO:0000479 "PhenX protocol: Migraine - Adult #130501" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000028
name: Adverse Drug Event
def: "An adverse event that occurs after a drug administration." []
synonym: "ADE" EXACT []
synonym: "ADR" EXACT []
synonym: "Adverse Drug Reaction" EXACT []
synonym: "Drug Adverse Event" EXACT []
xref: OAE:0000005
is_a: SCDO:1000093 ! Adverse Event (AE)
property_value: SCDO:0000303 "Should this be a sub-class of \"Environmental Disease Modifier\"?" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000005 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000028 xsd:string

[Term]
id: SCDO:0000029
name: Agarose Gel Electrophoresis
def: "Electrophoresis in which agar or agarose gel is used as the diffusion medium." []
synonym: "Agar Gel Electrophoresis" EXACT []
xref: MESH:D004587
is_a: SCDO:0000424 ! Electrophoresis
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004587 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000029 xsd:string

[Term]
id: SCDO:0000032
name: Agenesis of Corpus Callosum
def: "A rare congenital disorder characterized by a partial or complete absence (agenesis) of an area of the brain that connects the two cerebral hemispheres. It can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline." []
synonym: "Absence of Corpus Callosum" EXACT []
synonym: "Absent Corpus Callosum" EXACT []
synonym: "ACC" EXACT []
synonym: "Agenesis of the Corpus Callosum" EXACT []
synonym: "Callosal Agenesis" EXACT []
synonym: "Corpus Callosum Agenesis" EXACT []
synonym: "Dysplastic or Absent Corpus Callosum" EXACT []
is_a: HP:0002060 ! Abnormality of the Cerebrum
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C17230 ! diagnosed using tool Ultrasound Test
relationship: SCDO:0000664 SCDO:0000443 ! treated with Genetic Counseling
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:0000664 SCDO:0001133 ! treated with Symptomatic Therapeutics
property_value: SCDO:0000303 "Suggest update to description in HPO.\n\nInclude links to relevant Therapeutics." xsd:string
property_value: SCDO:0000340 HP:0001274
property_value: SCDO:0000340 http://rarediseases.org/rare-diseases/agenesis-of-corpus-callosum/ xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000034
name: Alanine Aminotransferase Blood Test
def: "A quantitative measurement of alanine aminotransferase present in a blood sample." []
synonym: "Alanine Transaminase Blood Test" EXACT []
synonym: "ALT Blood Test" EXACT []
synonym: "Circulating Alanine Transaminase Test" EXACT []
synonym: "Serum Glutamic-Pyruvic Transaminase Test" EXACT []
synonym: "SGPT Test" EXACT []
xref: NCIT:C64433
is_a: NCIT:C74954 ! Liver Function Test
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1000194 SCDO:0000035 ! measures Alanine Aminotransferase Level
property_value: http://purl.org/dc/elements/1.1/source https://medlineplus.gov/ency/article/003473.htm
property_value: SCDO:0000303 "Suggest update to description in NCIT (from \"Alanine Aminotransferase Measurement\")" xsd:string
property_value: SCDO:0000340 "details"
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000035
name: Alanine Aminotransferase Level
def: "The amount of alanine aminotransferase present in a specified volume of blood." []
synonym: "Alanine Aminotransferase Level" EXACT []
synonym: "Alanine Transaminase Level" EXACT []
synonym: "ALT Level" EXACT []
synonym: "Blood Alanine Transaminase Level" EXACT []
synonym: "Circulating Alanine Transaminase Level" EXACT []
synonym: "Serum Glutamic-Pyruvic Transaminase Level" EXACT []
synonym: "SGPT Level" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1000190 SCDO:0000034 ! obtained via diagnostic tool Alanine Aminotransferase Blood Test
relationship: SCDO:1000772 HP:0031964 ! has possible finding Elevated Serum Alanine Aminotransferase
relationship: SCDO:1000772 SCDO:1000830 ! has possible finding Normal Serum Alanine Aminotransferase
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000037
name: Albuminuria
def: "Increased concentration of albumin in the urine; more than 30mg in 24hours or urine albumin creatinine ratio (ACR) >3 mg/mmol." []
comment: Because albuminuria may be affected by non-pathological factors (exercise, menstruation contamination, biological variability, etc.), abnormal values should be confirmed within 1-2 months.
xref: HP:0012592
is_a: SCDO:0000932 ! Proteinuria
relationship: SCDO:0000664 SCDO:0000055 ! treated with Angiotensin-Converting Enzyme Inhibitors
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000220 SCDO:0001209 ! diagnosed using measurement Urine Albumin Concentration
relationship: SCDO:1000220 SCDO:0001210 ! diagnosed using measurement Urine Albumin Excretion Rate
relationship: SCDO:1000220 SCDO:0001212 ! diagnosed using measurement Urine Albumin-Creatinine Ratio
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/141501
property_value: SCDO:0000303 "Suggest update to description in HPO." xsd:string
property_value: SCDO:0000340 HP:0012592
property_value: SCDO:0000340 http://www.nice.org.uk/guidance/CG182/chapter/introduction xsd:string
property_value: SCDO:1000288 "Suggest update to description in HPO." xsd:string

[Term]
id: SCDO:0000038
name: Alcohol - Lifetime Use
def: "An indication of whether the respondent has ever consumed any alcoholic beverage during his or her entire life." []
is_a: NCIT:C81229 ! Alcohol Use History
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:1000329 ! obtained via diagnostic tool Alcohol - Lifetime Use Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0000042
name: Alpha Thalassemia
def: "A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted. A hemoglobinopathy with two clinically significant forms: hemoglobin Bart hydrops fetalis (deletion of all 4 alpha-globin genes; --/--) which is severe and often results in neonatal death; and hemoglobin H disease (most commonly caused by deletion of 3 alpha-globin genes; --/-alpha) which results in hemolytic anemia, splenomegaly and bone changes." []
synonym: "A-Thalassemia" EXACT []
synonym: "Alpha-Thalassemia" EXACT []
synonym: "Thalassemia Alpha" EXACT []
xref: MESH:D017085
is_a: NCIT:C35069 ! Thalassemia
is_a: OGMS:0000051 ! Constitutional Genetic Disorder
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000005 HP:0005560 ! modified by Imbalanced Hemoglobin Synthesis
relationship: SCDO:1000015 SCDO:0000251 ! modifies Clinical Phenotype of Beta Thalassemia
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
relationship: SCDO:1000172 EUPATH:0000034 ! has causal genotype Alpha Thalassemia Genotype
relationship: SCDO:1000210 SCDO:0001386 ! has causal or contributing genetic variation Alpha-Globin Locus Deletion
relationship: SCDO:1000218 HP:0001903 ! has manifestation Anemia
relationship: SCDO:1000223 SCDO:0001384 ! has causal molecular phenotype Reduced Alpha/Gamma Synthesis Ratio
property_value: SCDO:0000303 "Curation completed by the SCDO curator team: Clair." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017085 xsd:string
property_value: SCDO:0000340 "Origa R, Moi P. Alpha-Thalassemia. 2005 Nov 1 [Updated 2016 Dec 29]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1435/" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000042 xsd:string

[Term]
id: SCDO:0000045
name: Alpha-Adrenergic Agents
def: "Drugs that selectively bind to and activate alpha adrenergic receptors." []
synonym: "Adrenergic Alpha Agonists" EXACT []
synonym: "Adrenergic Alpha-Agonists" EXACT []
synonym: "Alpha Adrenergic Receptor Agonist" EXACT []
xref: MESH:D000316
is_a: SCDO:0000067 ! Antihypertensive Agents
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000316 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000045 xsd:string

[Term]
id: SCDO:0000046
name: Alpha-Globin Locus
def: "A region of chromosome 16 that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. It is responsible for the creation of the alpha parts (roughly half) of the oxygen transport protein Hemoglobin." []
synonym: "Alpha-Globin Gene Cluster" EXACT []
is_a: SCDO:0000456 ! Globin Locus
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology perhaps below \"Genetic Locus\"/\"Globin Locus\" (also to be included) in MESH." xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3050
property_value: SCDO:0000340 "synonyms"
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000049
name: Analgesia
def: "Methods of pain relief that may be used with or in place of analgesics." []
synonym: "Analgesias" EXACT []
xref: MESH:D000698
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000698 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000049 xsd:string

[Term]
id: SCDO:0000050
name: Analgesic
def: "A compound capable of relieving pain without the loss of consciousness." []
synonym: "Analgesic" EXACT []
synonym: "Analgesic Agent" EXACT []
synonym: "Analgesic Drugs" EXACT []
synonym: "Anodynes" EXACT []
synonym: "Antinociceptive Agent" EXACT []
synonym: "Pain Killers" EXACT []
synonym: "Painkiller" EXACT []
synonym: "Painkillers" EXACT []
xref: MESH:D000700
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 HP:0001342 ! treats Cerebral Hemorrhage
relationship: SCDO:1000018 HP:0001369 ! treats Arthritis
relationship: SCDO:1000018 HP:0001382 ! treats Joint Hypermobility
relationship: SCDO:1000018 HP:0002653 ! treats Bone Pain
relationship: SCDO:1000018 HP:0002829 ! treats Arthralgia
relationship: SCDO:1000018 HP:0003198 ! treats Myopathy
relationship: SCDO:1000018 HP:0003302 ! treats Spondylolisthesis
relationship: SCDO:1000018 HP:0003418 ! treats Back Pain
relationship: SCDO:1000018 HP:0004586 ! treats Biconcave Vertebral Bodies
relationship: SCDO:1000018 HP:0010885 ! treats Osteonecrosis
relationship: SCDO:1000018 HP:0011868 ! treats Sciatica
relationship: SCDO:1000018 HP:0030127 ! treats Endometriosis
relationship: SCDO:1000018 HP:0100774 ! treats Hyperostosis
relationship: SCDO:1000018 SYMP:0019161 ! treats Muscle Pain
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000700 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000050 xsd:string

[Term]
id: SCDO:0000053
name: Anesthetic Complication AE
def: "An adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment." []
xref: OAE:0002348
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0002348 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000053 xsd:string

[Term]
id: SCDO:0000054
name: Angioid Streaks
def: "Grayish, brown, or dark red streaks caused by cracks in Bruch's membrane that are histologically characterized by calcium deposition. Angioid streaks are most characteristic of sickle cell anemia and can occur to a lesser extent in other sickle cell syndromes, but not in sickle cell trait." []
xref: DOID:13401
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Suggest update to description in DO. Currently no description." xsd:string
property_value: SCDO:0000340 "Ballas et al 2010 Am J Hematol" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000055
name: Angiotensin-Converting Enzyme Inhibitors
def: "A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility." []
synonym: "ACE" EXACT []
synonym: "ACE Inhibitors" EXACT []
synonym: "Angiotensin Converting Enzyme" EXACT []
synonym: "Angiotensin Converting Enzyme Inhibitors" EXACT []
xref: MESH:D000806
is_a: SCDO:0000067 ! Antihypertensive Agents
relationship: SCDO:1000018 HP:0000112 ! treats Nephropathy
relationship: SCDO:1000018 HP:0003126 ! treats Tubular Proteinuria
relationship: SCDO:1000018 SCDO:0000037 ! treats Albuminuria
relationship: SCDO:1000018 SCDO:0000796 ! treats Nephrotic Syndrome
relationship: SCDO:1000018 SCDO:0000797 ! treats Nephrotic Range Proteinuria
relationship: SCDO:1000018 SCDO:0000932 ! treats Proteinuria
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000806 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000055 xsd:string

[Term]
id: SCDO:0000056
name: Annual Family Income
def: "The respondent's total family income from the last calendar year." []
xref: phenX:11100
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0001090 ! Socioeconomic Factors
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000574 ! has essential measure Household Roster-Relationships
property_value: SCDO:0000303 "Request inclusion into MESH below \"Income\".\n\nThe PhenX protocol is U.S. specific. Is there one relevant to the African setting?" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/11101
property_value: SCDO:0000479 "PhenX protocol: Annual Family Income #11101" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000057
name: Anti-Inflammatory Agent
def: "Substance that reduces or suppresses inflammation." []
synonym: "Anti Inflammatories" EXACT []
synonym: "Anti Inflammatory Agents" EXACT []
synonym: "Anti-Inflammatories" EXACT []
synonym: "Anti-Inflammatory Agents" EXACT []
synonym: "Anti-Inflammatory Drug" EXACT []
synonym: "Antiinflammatories" EXACT []
synonym: "Antiinflammatory Agents" EXACT []
xref: MESH:D000893
is_a: SCDO:0000809 ! Non Opioid
relationship: SCDO:1000018 HP:0000132 ! treats Menorrhagia
relationship: SCDO:1000018 HP:0001382 ! treats Joint Hypermobility
relationship: SCDO:1000018 HP:0002653 ! treats Bone Pain
relationship: SCDO:1000018 HP:0002725 ! treats Systemic Lupus Erythematosus
relationship: SCDO:1000018 HP:0002829 ! treats Arthralgia
relationship: SCDO:1000018 HP:0003198 ! treats Myopathy
relationship: SCDO:1000018 HP:0003302 ! treats Spondylolisthesis
relationship: SCDO:1000018 HP:0003418 ! treats Back Pain
relationship: SCDO:1000018 HP:0011868 ! treats Sciatica
relationship: SCDO:1000018 HP:0100774 ! treats Hyperostosis
relationship: SCDO:1000018 SYMP:0019161 ! treats Muscle Pain
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000893 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000057 xsd:string

[Term]
id: SCDO:0000066
name: Antihistamine
def: "Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only." []
synonym: "Antihistamines" EXACT []
synonym: "Histamine Antagonist" EXACT []
synonym: "Histamine Antagonists" EXACT []
xref: MESH:D006633
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 SCDO:0001073 ! treats Skin Rash
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006633 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000066 xsd:string

[Term]
id: SCDO:0000067
name: Antihypertensive Agents
def: "Used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. Among the antihypertensive agents are diuretics; (especially diuretics, thiazide); adrenergic aeta-antagonists; adrenergic alpha-antagonistics; angiotensin-converting enzyme inhibitors; calcium channel blockers; ganglionic blockers; and vasodilator agents." []
synonym: "Agents, Antihypertensive" EXACT []
synonym: "Anti Hypertensive Agent" EXACT []
synonym: "Anti-Hypertensives" EXACT []
synonym: "Antihypertensive Drug" EXACT []
synonym: "Antihypertensive Drugs" EXACT []
synonym: "Antihypertensives" EXACT []
xref: MESH:D000959
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001129 ! Supportive Therapeutics
relationship: SCDO:1000018 HP:0002076 ! treats Migraine
relationship: SCDO:1000018 HP:0002170 ! treats Intracranial Hemorrhage
relationship: SCDO:1000018 HP:0100601 ! treats Eclampsia
relationship: SCDO:1000018 SCDO:0000226 ! treats Chronic Kidney Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000959 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000067 xsd:string

[Term]
id: SCDO:0000069
name: APOL1
def: "This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Variants in the APOL1 gene can influence susceptibility to end-stage renal disease and Trypanosomiasis (African Sleeping Sickness)." []
synonym: "APO-L" EXACT []
synonym: "APOL" EXACT []
synonym: "APOL1 Gene" EXACT []
synonym: "Apolipoprotein L1 Gene" EXACT []
is_a: SCDO:0000810 ! Non-Globin Gene
property_value: SCDO:0000303 "Exists in other ontologies but we have provided a description more relevant to its relationship with SCD." xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/gene/8542 xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0000070
name: Aquatic Rehabilitation
def: "Exercises performed in or underwater for conditioning or rehabilitation (e.g., in injured athletes or patients with joint diseases)." []
synonym: "Aqua Therapy" EXACT []
synonym: "Hydrotherapy" EXACT []
is_a: SCDO:0000978 ! Rehabilitation
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/aquatic+therapy xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000071
name: Arterial Blood Gas Test
def: "A hematology assay that measures the acidity (pH) and the levels of oxygen and carbon dioxide in the blood from an artery. This test is used to check how well the lungs are able to move oxygen into the blood and remove carbon dioxide from the blood." []
synonym: "ABG Test" EXACT []
xref: ERO:0000533
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1000194 SCDO:0000849 ! measures Arterial Oxygen Saturation
property_value: SCDO:0000340 ERO:0000533
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000071 xsd:string

[Term]
id: SCDO:0000072
name: Arteriovenous Malformation
def: "Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas." []
synonym: "Arteriovenous Malformations" EXACT []
xref: MESH:D001165
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001165 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000072 xsd:string

[Term]
id: SCDO:0000073
name: Artesunate
def: "A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities." []
synonym: "Artesunic Acid" EXACT []
synonym: "Dihydroartemisinine 12 Alpha Succinate" EXACT []
xref: MESH:D000077332
is_a: IDOMAL:0000122 ! Malaria Chemoprophylaxis
is_a: SCDO:0001129 ! Supportive Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000077332
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000073 xsd:string

[Term]
id: SCDO:0000078
name: deprecated ASCQ-Me Score
def: "The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)." []
synonym: "ASCQ-Me - Quality of Life in SCD" EXACT []
synonym: "Sickle Cell Disease Adult Quality of Life Questionnaire Assessment Score" EXACT []
is_a: SCDO:0000359 ! deprecated terms
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820201 xsd:string
property_value: SCDO:0000303 "Is this term acceptable? \nIf so, request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string
is_obsolete: true
replaced_by: SCDO:1000296

[Term]
id: SCDO:0000079
name: Aspartate Aminotransferase Blood Test
def: "A bioassay to measure levels of aspartate aminotransferase (AST), which is released into the blood following tissue damage." []
synonym: "Aspartate Transaminase Blood Test" EXACT []
synonym: "AST Blood Test" EXACT []
synonym: "Serum AST Blood Test" EXACT []
xref: phenX:811201
is_a: NCIT:C74954 ! Liver Function Test
is_a: SCDO:0000133 ! Blood Test
is_a: SCDO:0000500 ! Heart Function Test
relationship: SCDO:1000194 SCDO:0000080 ! measures Aspartate Aminotransferase Level
property_value: SCDO:0000303 "Suggest update to PhenX label (\"Aspartate Aminotransferase Level\") also to NCIT label (from \"Aspartate Aminotransferase Measurement\")" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/811201
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000080
name: Aspartate Aminotransferase Level
def: "The amount of aspartate  aminotransferase present in a specified volume of blood." []
synonym: "Aspartate Transaminase Level" EXACT []
synonym: "AST Level" EXACT []
synonym: "Blood Aspartate Transaminase Amount" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000079 ! obtained via diagnostic tool Aspartate Aminotransferase Blood Test
relationship: SCDO:1000772 HP:0031956 ! has possible finding Elevated Serum Aspartate Aminotransferase
relationship: SCDO:1000772 SCDO:1000831 ! has possible finding Normal Serum Aspartate Aminotransferase
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000081
name: ASCQ-Me - Quality of Care in SCD
def: "A set of 27 questions administered to adults with sickle cell disease (SCD) to determine the quality of care that they have received from health care providers." []
synonym: "ASCQ-Me Quality of Care Module" EXACT []
is_a: SCDO:0000947 ! Quality of Care Measure
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Keller, S. D., Yang, M., Treadwell, M. J., Werner, E. M., & Hassell, K. L. (2014). Patient reports of health outcome for adults living with sickle cell disease: Development and testing of the ASCQ-Me item banks. Health and Quality of Life Outcomes, 12(1), 125. doi:10.1186/s12955-014-0125-0" xsd:string
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Quality of Care\")" xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820101 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Quality of Care - Adults #820101" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic Patients (Adults with SCD)" xsd:string
property_value: SCDO:0000486 "These questions are used to assess the patient-reported health care needs and quality of service from health care providers for individuals with chronic conditions such as sickle cell disease (SCD)." xsd:string
property_value: SCDO:0001222 "18 and older" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000082
name: Diagnostic Technique, Method, Test or Assay
def: "A planned process with the objective of producing diagnostic information about the material entity that is the evaluant, by physically examining it or its proxies." []
synonym: "Diagnostic Assay" EXACT []
synonym: "Diagnostic Method" EXACT []
synonym: "Diagnostic Technique" EXACT []
synonym: "Diagnostic Test" EXACT []
is_a: SCDO:1000032 ! Diagnostic Tool
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.obolibrary.org/obo/OBI_0000070 xsd:string
property_value: SCDO:0000303 "Possibly too specifiic to this ontology to be included in another ontology?\nUse structuring of sub-classes within MESH's \"Diagnostic Techniques and Procedures\" and NCIT's \"Diagnostic Procedure\" to inform structuring of terms in this class." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000084
name: Assessment of Short-Axis Cardiac Function by MRI
def: "This measure is a magnetic resonance imaging (MRI) method of capturing an individual's heart performance, and is considered the gold standard for capturing ventricular volumes and mass. It is used to detect cardiac abnormalities, such as cardiomyopathies, myocardial fibrosis, and infarction." []
synonym: "MRI of Short-Axis Cardiac Function" EXACT []
is_a: NCIT:C16809 ! Magnetic Resonance Imaging
is_a: SCDO:0000500 ! Heart Function Test
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Perhaps in the CPT." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/toolkit_content/supplemental_info/scd_cardio_pulm_renal/measures/Short_Axis_Function_20May2015.doc xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000086
name: Asthma
def: "A form of bronchial disorder with three distinct components: airway hyper-responsiveness, airway inflammation, and intermittent airway obstruction. It is characterized by spasmodic contraction of airway smooth muscle, wheezing and dyspnea." []
xref: MESH:D001249
is_a: HP:0002086 ! Abnormality of the Respiratory System
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Further work:\nis caused by links to be moved to object property links" xsd:string
property_value: SCDO:0000303 "Include a copy of this term below \"Comorbid Disease\" and/or below \"Respiratory System\"." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001249 xsd:string
property_value: SCDO:0000661 "Airway hyper-responsiveness" xsd:string
property_value: SCDO:0000661 "Airway inflammation" xsd:string
property_value: SCDO:0000661 "Intermittent airway obstruction" xsd:string
property_value: SCDO:0000662 "It is characterized by spasmodic contraction of airway smooth muscle, wheezing and dyspnea." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000086 xsd:string

[Term]
id: SCDO:0000088
name: Atopic Dermatitis
def: "A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema." []
synonym: "Atopic Eczema" EXACT []
synonym: "Baby Eczema" EXACT []
synonym: "Infantile Eczema" EXACT []
xref: MESH:D003876
is_a: HP:0011123 ! Skin Inflammation
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003876
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000088 xsd:string

[Term]
id: SCDO:0000094
name: BCL11A
def: "This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene." []
synonym: "B-cell CLL/lymphoma 11A (zinc finger protein)" EXACT []
synonym: "B-Cell CLL/Lymphoma 11A Gene" EXACT []
synonym: "B-cell CLL/lymphoma 11A Gene" EXACT []
synonym: "BAF Chromatin Remodeling Complex Subunit BCL11A Gene" EXACT []
synonym: "BCL-11A Gene" EXACT []
synonym: "BCL11A Gene" EXACT []
synonym: "Fetal Hemoglobin Quantitative Trait Locus 5" EXACT []
synonym: "HBFQTL5" EXACT []
is_a: SCDO:0000810 ! Non-Globin Gene
relationship: SCDO:1000015 SCDO:1000707 ! modifies Hemoglobin F Level
property_value: SCDO:0000303 "Link to \"Hereditary Persistence of fetal hemoglobin\"." xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/gene/53335 xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0000098
name: Bacteria
def: "One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to oxygen: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or phototrophy (via light reaction); for chemotrophs by their source of chemical energy: chemolithotrophy (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for carbon; nitrogen; etc.; heterotrophy (from organic sources) or autotrophy (from carbon dioxide). They can also be classified by whether or not they stain (based on the structure of their cell walls) with crystal violet dye: gram-negative or gram-positive." []
xref: MESH:D001419
is_a: OBI:0000925 ! Infectious Agent
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001419 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000098 xsd:string

[Term]
id: SCDO:0000102
name: Beck Anxiety Inventory (BAI)
def: "The BAI is the most widely used instument for measuring anxiety. It consists of 21 items to assess how bothersome a symptom of anxiety has been for the subject over the past month. Scoring the BAI is based on a 0-3 point scale with higher scores indicating severity." []
synonym: "BAI" EXACT []
synonym: "Beck Anxiety Inventory" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Could be as a child of \"Symptom Specific Assessment Tool\" in the NCIT." xsd:string
property_value: SCDO:0000340 "Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893-897." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic Patients" xsd:string
property_value: SCDO:0000484 "Spanish" xsd:string
property_value: SCDO:0001222 "17 years and older" xsd:string
property_value: SCDO:0001335 "yes" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000104
name: Behavior Rating Inventory of Executive Function
def: "The Behavior Rating Inventory of Executive Function (BRIEF) is a detailed questionnaire designed to assess executive function behaviors of children and adolescents in the school and home environments. The BRIEF is completed by parents and teachers." []
synonym: "BRIEF" EXACT []
synonym: "Executive Function - Child" EXACT []
xref: phenX:131102
is_a: SCDO:0001304 ! Executive Function Measure
property_value: SCDO:0000303 "Suggest update to label in PhenX." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/131102
property_value: SCDO:0000479 "PhenX protocol: #131102" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000106
name: Behaviour
def: "The actions or reactions of a person in response to a situation or stimuli." []
is_a: SCDO:0000746 ! Mental Health
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000107
name: Beliefs About Causes of Illness
def: "Personal or collective understanding of what the causes (could be predisposing factors, enabling factors, precipitating factors, reinforcing factors, and/or risk factors) are of a certain illness." []
comment: Cultural beliefs, such as re-incarnation and witchcraft, may influence notions on causality of sickle cell disease.
synonym: "Beliefs about Causality" EXACT []
is_a: SCDO:0000488 ! Health Beliefs
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/D015984 xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000108
name: Beliefs About Remedies and Treatment
def: "Personal or collective understanding of what can remedy or treat illness." []
is_a: SCDO:0000488 ! Health Beliefs
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.ncbi.nlm.nih.gov/mesh/68003469 xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps MESH." xsd:string
property_value: SCDO:1000288 "none" xsd:string

[Term]
id: SCDO:0000110
name: Beta Minus Thalassemia
def: "A beta-thalassemia caused by the reduced (beta-) synthesis of the beta globin chains of the hemoglobin (Hb) tetramer." []
synonym: "Beta - Thalassemia" EXACT []
synonym: "Beta Minus-Thalassemia" EXACT []
synonym: "Beta- Thalassemia" EXACT []
synonym: "Beta-Minus-Thalassemia" EXACT []
is_a: SCDO:0000111 ! Beta Thalassemia
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:0001765 ! has causal genotype Beta-Minus Thalassemia Mutation
relationship: SCDO:1000223 SCDO:0000976 ! has causal molecular phenotype Reduced Hemoglobin A
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps DOID." xsd:string
property_value: SCDO:0000340 "A. Cao and R. Galanello, \"Beta Thalassemia\", Genetics in Medicine, Vol. 12, No. 2, 2010, pp. 61 76. doi:10.1097/GIM.0b013e3181cd68ed" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000111
name: Beta Thalassemia
def: "A hemoglobinopathy characterized by the reduced (beta plus) or absent (beta zero) synthesis of the beta globin chains of hemoglobin, resulting in variable outcomes ranging from severe anemia to clinically asymptomatic individuals." []
synonym: "Beta Thalassemias" EXACT []
synonym: "Beta Type Thalassemia" EXACT []
synonym: "Beta-Thalassemia" EXACT []
synonym: "Beta-Thalassemias" EXACT []
synonym: "Hemoglobin F Disease" EXACT []
synonym: "Mediterranean Anemia" EXACT []
xref: DOID:12241
is_a: NCIT:C35069 ! Thalassemia
is_a: OGMS:0000051 ! Constitutional Genetic Disorder
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:0007624 ! has causal genotype Beta Thalassemia Genotype
relationship: SCDO:1000223 HP:0011906 ! has causal molecular phenotype Reduced Beta/Alpha Synthesis Ratio
relationship: SCDO:1000223 SCDO:1000240 ! has causal molecular phenotype Reduced or Absent Hemoglobin A
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "Suggest update to description in DOID.\n\nInclude a \"Dominant Beta-Thalassemia\" sub-class? (see Orphanet)" xsd:string
property_value: SCDO:0000340 "A. Cao and R. Galanello, \"Beta Thalassemia\", Genetics in Medicine, Vol. 12, No. 2, 2010, pp. 61 76. doi:10.1097/GIM.0b013e3181cd68ed" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Beta_thalassemia xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/DOID_12241 xsd:string
property_value: SCDO:0000340 "Origa R. Beta-Thalassemia. 2000 Sep 28 [Updated 2018 Jan 25]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1426/" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000112
name: Beta Thalassemia Intermedia
def: "A homozygous (B+/B+) or compound heterozygous (B0/B+) form of beta-thalassemia characterized by mild to moderate anemia which does not or only occasionally requires transfusion." []
synonym: "B+/B+" EXACT []
synonym: "B0/B+" EXACT []
synonym: "Beta-Thalassemia Intermedia" EXACT []
synonym: "Thalassemia Intermedia" EXACT []
xref: ORPHA:231222
is_a: SCDO:0000251 ! Clinical Phenotype of Beta Thalassemia
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:1000218 HP:0000952 ! has manifestation Jaundice
relationship: SCDO:1000218 HP:0001081 ! has manifestation Cholelithiasis
relationship: SCDO:1000218 HP:0001640 ! has manifestation Cardiomegaly
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000218 HP:0001903 ! has manifestation Anemia
relationship: SCDO:1000218 HP:0002149 ! has manifestation Hyperuricemia
relationship: SCDO:1000218 NCIT:C78393 ! has manifestation Iron Overload
relationship: SCDO:1000218 SCDO:0000685 ! has manifestation Leg Ulcer
relationship: SCDO:1000218 SCDO:0006905 ! has manifestation Hypersplenism
property_value: SCDO:0000340 Orphanet:231222
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000112 xsd:string

[Term]
id: SCDO:0000113
name: Beta Thalassemia Major
def: "A severe early-onset form of beta thalassemia characterized by severe anemia requiring regular red blood cell transfusions." []
synonym: "B0/B0" EXACT []
synonym: "Beta-Thalassemia Major" EXACT []
synonym: "BT Major" EXACT []
synonym: "Cooley Anemia" EXACT []
synonym: "Cooley's Anemia" EXACT []
synonym: "Mediterranean Anemia" EXACT []
synonym: "Thalassemia Major" EXACT []
xref: ORPHA:231214
is_a: SCDO:0000251 ! Clinical Phenotype of Beta Thalassemia
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:1000218 HP:0000819 ! has manifestation Diabetes Mellitus
relationship: SCDO:1000218 HP:0000821 ! has manifestation Hypothyroidism
relationship: SCDO:1000218 HP:0000823 ! has manifestation Delayed Puberty
relationship: SCDO:1000218 HP:0000939 ! has manifestation Osteoporosis
relationship: SCDO:1000218 HP:0001081 ! has manifestation Cholelithiasis
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000218 HP:0001903 ! has manifestation Anemia
relationship: SCDO:1000218 HP:0002007 ! has manifestation Frontal Bossing
relationship: SCDO:1000218 HP:0012418 ! has manifestation Hypoxemia
relationship: SCDO:1000218 IDO:0000586 ! has manifestation Infection
relationship: SCDO:1000218 MP:0002412 ! has manifestation Increased Susceptibility to Bacterial Infection
relationship: SCDO:1000218 NCIT:C2890 ! has manifestation Bacterial Infection
relationship: SCDO:1000218 NCIT:C3439 ! has manifestation Viral Infection
relationship: SCDO:1000218 NCIT:C78393 ! has manifestation Iron Overload
relationship: SCDO:1000218 SCDO:0000465 ! has manifestation Growth Delay
relationship: SCDO:1000218 SCDO:0000685 ! has manifestation Leg Ulcer
relationship: SCDO:1000218 SCDO:0000943 ! has manifestation Pulmonary Hypertension
relationship: SCDO:1000218 SCDO:0005167 ! has manifestation Chronic Anemia
relationship: SCDO:1000218 SCDO:0006905 ! has manifestation Hypersplenism
property_value: SCDO:0000340 Orphanet:231214
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000113 xsd:string

[Term]
id: SCDO:0000114
name: Beta Thalassemia Trait
def: "The inheritance of only one mutated beta-globin allele (beta+ or beta0)." []
synonym: "B-/B" EXACT []
synonym: "B0/B" EXACT []
synonym: "Beta Thalassemia Minor" EXACT []
synonym: "Beta-Thalassemia Trait" EXACT []
synonym: "Heterozygosity for Beta-Thalassemia" EXACT []
synonym: "Heterozygous Beta-Thalassemia" EXACT []
is_a: SCDO:0000251 ! Clinical Phenotype of Beta Thalassemia
is_a: SCDO:0000551 ! Thalassemia Trait
relationship: SCDO:1000015 NCIT:C95504 ! modifies Hemoglobin H Disease
relationship: SCDO:1000172 SCDO:0009731 ! has causal genotype Beta Thalassemia Mutation
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Perhaps below \"clinical subtype\" in Orphanet.\n\nThe exact synonym \"B+/B\" has been changed to \"B-/B\", as per the change in convention from \"Beta Plus Thalassemia\" to \"Beta Minus Thalassemia\"." xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Beta_thalassemia xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000115
name: Beta Zero Thalassemia
def: "Beta-zero thalassemia is a form of beta-thalassemia in which beta-globin chain synthesis is absent. The clinical phenotype is often that of transfusion-dependant beta thalassemia major, however modifying factors may ameliorate the symptoms of severe anemia (Cao & Gallanelo, 2010)." []
synonym: "Beta 0 Thalassemia" EXACT []
synonym: "Beta Zero-Thalassemia" EXACT []
synonym: "Beta-Zero-Thalassemia" EXACT []
synonym: "Beta0 Thalassemia" EXACT []
synonym: "Hb Beta Zero-Thalassemia" EXACT []
synonym: "Hb F only" EXACT []
is_a: SCDO:0000111 ! Beta Thalassemia
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0000664 SCDO:0001329 ! treated with Folic Acid
relationship: SCDO:0000664 SCDO:0008888 ! treated with Iron Chelation Therapy
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:0002475 ! has causal genotype Beta-Zero Thalassemia Mutation
relationship: SCDO:1000223 SCDO:1000241 ! has causal molecular phenotype Absent Hemoglobin A
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps DOID." xsd:string
property_value: SCDO:0000340 "A. Cao and R. Galanello, \"Beta Thalassemia\", Genetics in Medicine, Vol. 12, No. 2, 2010, pp. 61 76. doi:10.1097/GIM.0b013e3181cd68ed" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000116
name: Beta-Globin Locus
def: "A globin locus composed of five genes located on a short 45 kb region of chromosome 11. The order of genes in this cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. It is responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin." []
synonym: "Beta-Globin Cluster" EXACT []
synonym: "Beta-Globin Gene Cluster" EXACT []
synonym: "HBB Locus" EXACT []
is_a: SCDO:0000456 ! Globin Locus
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology perhaps below \"Genetic Locus\"/\"Globin Locus\" (also to be included) in MESH." xsd:string
property_value: SCDO:0000340 https://en.wikipedia.org/wiki/HBD
property_value: SCDO:0000340 https://en.wikipedia.org/wiki/Human_%CE%B2-globin_locus
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000117
name: Beta-Globin Haplotype
def: "Defined arrays of polymorphic gene sites that are inherited together across the genetic vicinity of the beta-globin gene or gene cluster on chromosome 11." []
synonym: "Beta-Globin Haplotypes" EXACT []
synonym: "Beta-Haplotypes" EXACT []
synonym: "Beta-S Haplotype" EXACT []
synonym: "Beta-S Haplotypes" EXACT []
is_a: NCIT:C63547 ! Haplotype
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
relationship: SCDO:1000015 SCDO:1000707 ! modifies Hemoglobin F Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Nagel, et. al. NEngl J Med. 1985 Apr 4;312(14):880-4" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000119
name: Bilirubin Blood Test
def: "A bioassay to measure levels of bilirubin, a yellow substance found in bile produced when the liver breaks down old red blood cells." []
xref: phenX:810901
is_a: NCIT:C74954 ! Liver Function Test
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000194 CMO:0000123 ! measures Blood Bilirubin Level
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Bilirubin Level\")." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810901
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000120
name: Biochemical Assay
def: "An analytical in vitro procedure used to detect, quantify and/or study the binding or activity of a biological molecule, such as an enzyme." []
is_a: SCDO:0000216 ! Chemical Assay
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 http://www.nature.com/subjects/biochemical-assays xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000122
name: Biological Disease Modifier
def: "A biological factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease." []
is_a: SCDO:0000391 ! Disease Modifier
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000123
name: Birthplace
def: "The country in which the respondent was born." []
synonym: "Place of Birth" EXACT []
is_a: NCIT:C16495 ! Demographic Factor
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocols&id=010200 xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000124
name: Birthplace of Biological Father
def: "The country in which the respondent's biological father was born." []
is_a: SCDO:0000129 ! Birthplace of Parents
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000125
name: Birthplace of Biological Mother
def: "The country in which the respondent's biological mother was born." []
is_a: SCDO:0000129 ! Birthplace of Parents
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000126
name: Birthplace of Grandparents
def: "The country or countires in which the respondent's biological grandparents were born." []
is_a: NCIT:C16495 ! Demographic Factor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/10401
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nThere is a protocol in PhenX but it is US specific." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000127
name: Birthplace of Maternal Grandfather
def: "The country in which the respondent's biological maternal (on the mother's side of the family) grandfather was born." []
is_a: SCDO:0000126 ! Birthplace of Grandparents
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000128
name: Birthplace of Maternal Grandmother
def: "The country in which the respondent's biological maternal (on the mother's side of the family) grandmother was born." []
is_a: SCDO:0000126 ! Birthplace of Grandparents
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000129
name: Birthplace of Parents
def: "The country or countires in which the respondent's biological parents were born." []
is_a: NCIT:C16495 ! Demographic Factor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/10301
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nThere is a protocol in PhenX but it is US specific." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000130
name: Birthplace of Paternal Grandfather
def: "The country in which the respondent's biological paternal (on the father's side of the family) grandfather was born." []
is_a: SCDO:0000126 ! Birthplace of Grandparents
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000131
name: Birthplace of Paternal Grandmother
def: "The country in which the respondent's biological paternal (on the father's side of the family) grandmother was born." []
is_a: SCDO:0000126 ! Birthplace of Grandparents
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000132
name: Black Sunburst Lesion
def: "Black lesions in the retina that form at the border of perfused and nonperfused retina that are caused by the migration of hyperplastic retinal pigment epithelial cells into sensory retina. The sensory retina surrounding the lesion is atrophic." []
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:0000663 NCIT:C75583 ! diagnosed using tool Slit-Lamp Examination
relationship: SCDO:0000663 SCDO:0000835 ! diagnosed using tool Ophthalmoscopy
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 "Ballas et al 2010 Am J Hematol" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000133
name: Blood Test
def: "Test used in the analysis of the hemic system." []
synonym: "Blood Assay" EXACT []
synonym: "Blood Tests" EXACT []
synonym: "Hematologic Test" EXACT []
synonym: "Hematologic Tests" EXACT []
synonym: "Hematological Test" EXACT []
synonym: "HematologyTest" EXACT []
xref: MESH:D006403
is_a: SCDO:0000902 ! Physiological Assay
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006403 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000133 xsd:string

[Term]
id: SCDO:0000138
name: Blood Component Transfusion
def: "The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in plasmapheresis and types of cytapheresis; (plateletpheresis and leukapheresis) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor." []
xref: MESH:D016913
is_a: SCDO:0000147 ! Blood Transfusion
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016913 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000138 xsd:string

[Term]
id: SCDO:0000139
name: Blood Culture
def: "Test to determine the presence of blood infection (e.g. sepsis; bacteremia)." []
synonym: "BC" EXACT []
synonym: "Culture Blood" EXACT []
synonym: "Haemoculture" EXACT []
synonym: "Hemoculture" EXACT []
xref: MESH:D000071997
is_a: SCDO:0000133 ! Blood Test
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000071997
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000139 xsd:string

[Term]
id: SCDO:0000147
name: Blood Transfusion
def: "The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)" []
comment: The major and unavoidable complication of transfusions in sickle cell disease is iron overload.\n\nTransfusion is well-defined as prophylaxis (stroke) and as therapy (acute chest syndrome and stroke) for major complications of sickle cell disease and has been instituted, based on less conclusive data, for a range of additional complications, such as priapism, vaso-occlusive crises, leg ulcers, pulmonary hypertension, and during complicated pregnancies.
synonym: "Blood Transfusions" EXACT []
xref: MESH:D001803
is_a: SCDO:0000922 ! Preventative Therapeutics
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 DOID:1584 ! treats Acute Chest Syndrome
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 HP:0000112 ! treats Nephropathy
relationship: SCDO:1000018 HP:0001789 ! treats Hydrops Fetalis
relationship: SCDO:1000018 HP:0004727 ! treats Impaired Renal Concentrating Ability
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1000018 NCIT:C155312 ! treats Sickle Cell Chronic Lung Disease
relationship: SCDO:1000018 NCIT:C92853 ! treats Postpartum Hemorrhage
relationship: SCDO:1000018 NCIT:C95504 ! treats Hemoglobin H Disease
relationship: SCDO:1000018 NCIT:C98835 ! treats Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000018 SCDO:0000519 ! treats Hemoglobin C Disease
relationship: SCDO:1000018 SCDO:0000530 ! treats Hemoglobin E Disease
relationship: SCDO:1000018 SCDO:0000812 ! treats Non-specific Acute Lower Respiratory Tract Episode
relationship: SCDO:1000018 SCDO:0000972 ! treats Recurrent Wheeze in Sickle Cell Disease
relationship: SCDO:1000018 SCDO:0001064 ! treats Sickle Cell Disease-S/O-Arab
relationship: SCDO:1000018 SCDO:1000077 ! treats Moderate Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1000018 SCDO:1000078 ! treats Severe Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/source http://www.hindawi.com/journals/ah/2010/272940/
property_value: http://purl.org/dc/elements/1.1/source "Radha Raghupathy, Deepa Manwani, and Jane A. Little, “Iron Overload in Sickle Cell Disease,” Advances in Hematology, vol. 2010, Article ID 272940, 9 pages, 2010. doi:10.1155/2010/272940" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001803 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000147 xsd:string

[Term]
id: SCDO:0000149
name: Body Height
def: "The distance from the sole to the crown of the head with body standing on a flat surface and fully extended." []
synonym: "Height" EXACT []
synonym: "Height/Length" EXACT []
synonym: "Length/Height" EXACT []
xref: EFO:0004339
is_a: CMO:0000011 ! Whole Body Morphological Measurement
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_0004339 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000149 xsd:string

[Term]
id: SCDO:0000152
name: Body Weight
def: "The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms." []
synonym: "Weight" EXACT []
xref: MESH:D001835
is_a: CMO:0000011 ! Whole Body Morphological Measurement
property_value: SCDO:0000303 "Add these terms from PhenX?: -- - Weight Loss/Gain" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001835
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000152 xsd:string

[Term]
id: SCDO:0000155
name: deprecated-Bone Sclerosis
def: "An abnormal hardening or increased density of bone tissue." []
comment: The bone is more radiopaque than normal on a plain film.
synonym: "Bone Scleroses" EXACT []
synonym: "Osteoscleroses" EXACT []
synonym: "Osteosclerosis" EXACT []
xref: MESH:D010026
is_a: SCDO:0001336 ! from phenotype
property_value: http://purl.org/dc/elements/1.1/source "Segen's Medical Dictionary. S.v. \"bone sclerosis.\" Retrieved April 30 2019 from https://medical-dictionary.thefreedictionary.com/bone+sclerosis" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D010026
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000155 xsd:string
is_obsolete: true
replaced_by: SCDO:0000629

[Term]
id: SCDO:0000156
name: Brachial Artery Ultrasound Imaging
def: "A noninvasive method to assess the endothelial dysfunction in the brachial artery." []
synonym: "BAUI" EXACT []
is_a: NCIT:C17230 ! Ultrasound Test
is_a: SCDO:0001228 ! Endothelial Function Test
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Endothelial_dysfunction xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000161
name: Brain Electrical Activity
def: "Voltages between parts of the brain that are detectable with an electroencephalograph." []
synonym: "Brain Electrophysiological Activity" EXACT []
synonym: "Brain Oscillography" EXACT []
synonym: "EEG activity" EXACT []
xref: CRISP:0487-1238
is_a: SCDO:0000728 ! Diagnostic Measurement
relationship: SCDO:1000190 SCDO:0000420 ! obtained via diagnostic tool Electroencephalography
relationship: SCDO:1000193 SCDO:0000419 ! output of diagnostic device Electroencephalograph
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/CRISP?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FCSP%2F0487-1238
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000161 xsd:string

[Term]
id: SCDO:0000162
name: Breakthrough Pain
def: "An episode of severe pain that occurs with rapid onset even when pain-control medication is being used. Breakthrough pain can occur spontaneously or in relation to a specific activity, and can last from a few seconds to a few hours." []
comment: There are currently no data that clearly describe or can be used to define breakthrough pain in SCD.
xref: NCIT:C9203
is_a: SCDO:0000233 ! Chronic Sickle Cell Pain
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/source "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:0000340 "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C9203
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000163
name: Brief Illness Perception Questionnaire (B-IPQ)
def: "The Brief IPQ has 9 items, 8 new items from the IPQ plus a causal question. All of the items except the causal question are rated using a 0-to-10-response scale. Five of the items assess Cognitive Illness Representations: Consequences (Item 1), Timeline (Item 2), Personal Control (Item 3), Treatment Control (Item 4), and Identity (Item 5). Two of the items assess Emotional Representations: Concern (Item 6) and Emotions (Item 8). One item assesses Illness Comprehensibility (Item 7). Assessment of the Causal Representation is by an open-ended response item adapted, which asks patients to list the three most important causal factors in their illness (Item 9). Responses to the causal item can be grouped into categories such as stress, lifestyle, hereditary, etc, determined by the particular illness studied, and categorical analysis can then be performed." []
synonym: "B-IPQ" EXACT []
synonym: "Brief Illness Perception Questionnaire" EXACT []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: http://purl.org/dc/elements/1.1/source "Broadbent E, Petrie KJ, Main J, Weinman, J. (2006). The brief illness perception questionnaire. Journal of Psychosomatic Research, 60, 631-637." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Broadbent E, Petrie KJ, Main J, Weinman, J. (2006). The brief illness perception questionnaire. Journal of Psychosomatic Research, 60, 631-637." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic Patients" xsd:string
property_value: SCDO:0000484 "Many" xsd:string
property_value: SCDO:0001033 "Good psychometric properties, widely used, has been translated into several languages." xsd:string
property_value: SCDO:0001222 "Adults" xsd:string
property_value: SCDO:0001335 "yes" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000164
name: Brief RCOPE
def: "Brief RCOPE is a 14-item instrument that measures religious coping with major life stressors. Responses on the Brief RCOPE indicate the frequency with which participants have used R/S coping behaviors on a Likert scale of 1 (not at all) to 4 (a great deal.) The scale has been used to examine positive and negative religious coping, including in teens with SCD." []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Pargament K, Koenig H, Perez L. The many methods of religious coping: development and initial validation of the RCOPE. J Clin Psychol. 2000;56:519-543." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Pargament K, Koenig H, Perez L. The many methods of religious coping: development and initial validation of the RCOPE. J Clin Psychol. 2000;56:519-543." xsd:string
property_value: SCDO:0000481 "Self; Proxy (Parent report)" xsd:string
property_value: SCDO:0000482 "Children with SCD and their parents." xsd:string
property_value: SCDO:0001033 "Demonstrated validity in SCD studies." xsd:string
property_value: SCDO:0001222 "Children and adults" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000165
name: Bronchodilator Responsiveness
def: "The improvement of forced expiratory volume in 1 second (FEV1) after inhalation of beta2-agonists and is typically measured as the change in airflow after the administration of short-acting beta2-adrenergic agonists (SABAs)." []
synonym: "BDR" EXACT [] {synonymtypedef="abbreviation"}
is_a: CMO:0000094 ! Respiratory System Measurement
relationship: SCDO:1000190 SCDO:0000166 ! obtained via diagnostic tool Bronchodilator Responsiveness Test
property_value: SCDO:0000303 "Suggest that the description be updated in PhenX (https://www.phenxtoolkit.org/protocols/view/90301)" xsd:string
property_value: SCDO:0000340 "Bauer S, Park HN, Seo HS, et al. Assessment of bronchodilator responsiveness following methacholine-induced bronchoconstriction in children with asthma. Allergy Asthma Immunol Res. 2011;3(4):245-50." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000166
name: Bronchodilator Responsiveness Test
def: "A test to assess an individual's change in pulmonary function in response to inhaled bronchodilator medications." []
synonym: "BDR Test" EXACT []
synonym: "Bronchodilator Responsiveness Testing" EXACT []
xref: phenX:90301
is_a: SCDO:0000942 ! Pulmonary Function Test
relationship: SCDO:0001297 NCIT:C85397 ! has essential measure Spirometry
relationship: SCDO:1000194 SCDO:0000165 ! measures Bronchodilator Responsiveness
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Bronchodilator Responsiveness (BDR)\")\n\nCan also suggest inclusion in MESH below \"Respiratory Function Tests\"" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/90301
property_value: SCDO:0000479 "PhenX protocol: Bronchodilator Responsiveness (BDR) #90301" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000182
name: Capillary Electrophoresis
def: "A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of proteins; nucleic acids; and carbohydrates. (Segen, Dictionary of Modern Medicine, 1992)" []
synonym: "Capillary Electrophoreses" EXACT []
synonym: "Capillary Zone Electrophoreses" EXACT []
synonym: "Capillary Zone Electrophoresis" EXACT []
xref: MESH:D019075
is_a: SCDO:0000424 ! Electrophoresis
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D019075 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000182 xsd:string

[Term]
id: SCDO:0000183
name: Cardioscope
def: "An instrument which, by means of a cathode-ray oscillograph, projects an electrocardiographic record on a luminous screen." []
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 SCDO:0000417 ! used by diagnostic tool Electrocardiography
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 http://encyclopedia2.thefreedictionary.com/cardioscope xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000187
name: deprecated Cardiovascular System
def: "'Anatomical system that has as its parts the heart and blood vessels. [Curator team: []]'" []
synonym: "CV system" EXACT []
xref: UBERON:0004535
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/UBERON_0004535 xsd:string
is_obsolete: true
replaced_by: SCDO:0002245

[Term]
id: SCDO:0000188
name: obsolete Case Reports
def: "'Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis. [Curator team: []]'" []
synonym: "Case Histories" EXACT []
synonym: "Case Studies" EXACT []
synonym: "Case Study" EXACT []
xref: MESH:D002363
is_a: SCDO:0000941 ! obsolete Publication Type
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D002363 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000189
name: Case-Control Studies
def: "Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group." []
synonym: "Case-Referrent Studies" EXACT []
xref: MESH:D016022
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000303 "Suggest update to description in MESH" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016022 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000190
name: Catheter
def: "A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity." []
synonym: "Cannula" EXACT []
synonym: "Cannulas" EXACT []
synonym: "Catheters" EXACT []
xref: MESH:D057785
is_a: SCDO:0000376 ! Diagnostic Device
is_a: SCDO:0001150 ! Therapeutic Device
relationship: SCDO:1000191 NCIT:C80411 ! used by diagnostic tool Right Heart Catheterization
property_value: SCDO:0000303 "Add info (rdfs:comment) about how catheters are used in different therapeutics. --  -- Link relevant Therapeutics term(s) to this term via \"has medical device\"." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D057785 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000190 xsd:string

[Term]
id: SCDO:0000191
name: Causal Adverse Drug Event
def: "A drug adverse event that is caused by a drug administration. Here a causal effect is established between the drug administration and the adverse event." []
xref: OAE:0000095
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000303 "Suggest definition replaced in OAE. Currenlty it's shown as the definition editor." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000095 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000192
name: Causal Adverse Drug Event Due to Drug-Drug Interaction
def: "A causal adverse drug event that is induced by a drug-drug interaction." []
xref: OAE:0000179
is_a: SCDO:0000191 ! Causal Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000179 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000192 xsd:string

[Term]
id: SCDO:0000193
name: Causal Adverse Drug Event Due to Food-Drug Interaction
def: "A causal adverse drug event that is induced by a food-drug interaction." []
xref: OAE:0000180
is_a: SCDO:0000191 ! Causal Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000180 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000193 xsd:string

[Term]
id: SCDO:0000194
name: Causal Adverse Drug Event Due to Genetic Predisposition
def: "A causal adverse drug event that is induced by genetic predisposition." []
xref: OAE:0000181
is_a: SCDO:0000191 ! Causal Adverse Drug Event
property_value: SCDO:0000303 "Suggest small typo to be fixed in OAE." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000181 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000195
name: Causal Adverse Drug Event Due to SNP
def: "A causal adverse drug event due to genetic predisposition that is specifically induced by SNP." []
xref: OAE:0000182
is_a: SCDO:0000194 ! Causal Adverse Drug Event Due to Genetic Predisposition
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000182 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000195 xsd:string

[Term]
id: SCDO:0000198
name: Cell Free Hemoglobin Blood Test
def: "The determination of the amount of free hemoglobin present in a sample." []
synonym: "Cell Free Hemoglobin Assay" EXACT []
synonym: "Cell Free Hemoglobin Blood Assay" EXACT []
synonym: "Cell Free Hemoglobin Test" EXACT []
synonym: "Free Hemoglobin Blood Test" EXACT []
synonym: "HGBFR Test" EXACT []
xref: NCIT:C127617
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1000194 SCDO:0000199 ! measures Cell Free Hemoglobin Level
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Free Hemoglobin Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C127617
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000199
name: Cell Free Hemoglobin Level
def: "The level of hemoglobin external to erythrocytes in a biological specimen." []
synonym: "Cell Free Haemoglobin Level" EXACT []
synonym: "Cell Free Hemoglobin Concentration" EXACT []
synonym: "Extracellular Hb Level" EXACT []
synonym: "Extracellular Hemoglobin Level" EXACT []
synonym: "HGBFR Level" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1000190 SCDO:0000198 ! obtained via diagnostic tool Cell Free Hemoglobin Blood Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nIf wanting to include \"Plasma Hemoglobin Level\" in the future, see CMO:0000588 for a description. synonyms: Plasma Free Hemoglobin (PFHb) Level, Plasma Hemoglobin Level." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000206
name: Cerebral Collateral Flow
def: "Cerebral collateral circulation is a subsidiary vascular network which is dynamically recruited after arterial occlusion and may provide residual blood flow to ischemic areas." []
synonym: "Cerebral Collateral Circulation" EXACT []
is_a: SCDO:0000213 ! Cerebrovascular Hemodynamics
relationship: SCDO:1000190 SCDO:0001166 ! obtained via diagnostic tool Transcranial Doppler Ultrasonography
property_value: SCDO:0000303 "The description doesn't actually describe the term. Needs revision.\n\nPerhaps: Blood flow through cerebral collateral circulation, a subsidiary vascular network which is dynamically recruited after arterial occlusion and which may provide residual blood flow to ischemic areas.\n\nSuggest inclusion into CMO, below \"circulation measurement\"." xsd:string
property_value: SCDO:0000340 "Cerebral collateral circulation in experimental ischemic stroke. Elisa Cuccione, Giada Padovano, Alessandro Versace, Carlo Ferrarese, Simone Beretta. Exp Transl Stroke Med. 2016; 8: 2. Published online 2016 Mar 1. doi: 10.1186/s13231-016-0015-0\nPMCID: PMC4772465" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000208
name: Cerebral Function Assay
def: "A test of how well the cerebrum is functioning." []
synonym: "Cerebral Function Test" EXACT []
is_a: SCDO:0000902 ! Physiological Assay
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000213
name: Cerebrovascular Hemodynamics
def: "The movement and the forces involved in the movement of the blood through the blood vessels in the brain." []
is_a: CMO:0000195 ! Blood Flow Measurement
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C62581
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/D006439
property_value: SCDO:0000303 "Request inclusion into relevant ontology.\nPerhaps replace with \"cerebral blood flow measurement\" from the EFO?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000216
name: Chemical Assay
def: "The analysis of a sample material, called an analyte, using a set of chemical procedures." []
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 http://www.reference.com/science/chemical-assay-80cfe6f498d34be5 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000217
name: Chest X-Ray
def: "A medical imaging assessment of the chest wall, airways, lungs, pulmonary vessels, heart, mediastinum, and pleura." []
synonym: "Chest Radiograph" EXACT []
xref: phenX:810201
is_a: SCDO:0000963 ! Radiography
relationship: SCDO:1000192 OBI:0001138 ! uses diagnostic device X-Ray Machine
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810201
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000217 xsd:string

[Term]
id: SCDO:0000218
name: Child Health Questionnaire (CHQ)
def: "The Child Health Questionnaire (CHQ) is a family of general quality of life surveys that measures 14 unique physical and psychosocial concepts. The parent form is available in 2 lengths - the CHQ-PF50 and the CHQ-PF28. The child self-reported version of the CHQ consists of 87 items (CHQ-CF87)." []
synonym: "Child Health Questionnaire" EXACT []
synonym: "CHQ" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Landgraf, J. M., Abetz, L., and Ware, J. E. (1996). Child health questionnaire (CHQ): A user's manual (1st Ed.). Boston, M.A.: The Health Institute, New England Medical Center." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Panepinto JA, O'Mahar KM, DeBaun MR, Rennie KM, Scott JP. Validity of the child health questionnaire for use in children with sickle cell disease. J Pediatr Hematol Oncol. 2004 Sep;26(9):574-8." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Wrotniak BH, Schall JI, Brault ME, Balmer DF, Stallings VA. Health-related quality of life in children with sickle cell disease using the child health questionnaire. J Pediatr Health Care. 2014 Jan-Feb;28(1):14-22. doi: 10.1016/j.pedhc.2012.09.004. Epub 2012 Nov 8." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self, Proxy" xsd:string
property_value: SCDO:0000482 "Healthy Children; Children with Medical Conditions" xsd:string
property_value: SCDO:0000484 "French, isiXhosa, isiZulu, Portuguese, Punjabi, Sesotho, Temil, Telugu, Gujarati" xsd:string
property_value: SCDO:0001033 "Demonstrated validity with SCD populations; at least two publications using the measure in SCD." xsd:string
property_value: SCDO:0001222 "5 to 18 years (child report 10 - 18 years; parent report 5 - 18 years)" xsd:string
property_value: SCDO:0001335 "yes" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000219
name: Child-Reported Parental Education Attainment
def: "A parent's highest level of education obtained, as reported by the child." []
xref: phenX:210201
is_a: SCDO:0000305 ! Current Educational Attainment
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Request inclusion into MESH below \"Current Educational Attainment\" (also to be suggested), below \"Socioeconomic Factors\".\nAlso suggest inclusion in the EFO, below measurement." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/210201
property_value: SCDO:0000479 "PhenX protocol: Child-Reported Parental Education Attainment #210201" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000220
name: Children's Depression Inventory 2 (CDI 2)
def: "The CDI-2 is a 27-item self-report scale that helps to assess cognitive, affective and behavioral signs of depression in children and adolescents. Each item is scored on a scale from 0 to 2." []
synonym: "CDI 2" EXACT []
synonym: "CDI-2" EXACT []
synonym: "Children's Depression Inventory 2" EXACT []
synonym: "Children's Depression Inventory-2" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "Kovacs, M. (1985). The Children's Depression, Inventory (CDI). Psychopharmacology Bulletin, 21, 995-998." xsd:string
property_value: SCDO:0000303 "Check and show which source was used for the description and whether the description was adapted from the source." xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Could be as a child of \"Symptom Specific Assessment Tool\" in the NCIT." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic Patients" xsd:string
property_value: SCDO:0001222 "7 to 17 years" xsd:string
property_value: SCDO:0001335 "yes" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000221
name: Children's Health Locus of Control Scale (CHLC)
def: "A measure that seeks to determine the extent to which children and adolescents believe their own health-related behaviors will influence their health. It is a 20 item scale that contains 3 additional practice items and is a yes or no format. It contains 3 factors: belief in internality, belief in powerful others and belief in chance. There is a shorter 9-item version of the scale which is comparable to the full version and adapted for use in Egyptian children." []
synonym: "Children's Health Locus of Control Scale" EXACT []
synonym: "CHLC" EXACT []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: SCDO:0000340 "Abdel Gawwad E, Ahmed MH, Kamal MM.  Developing and testing of an Egyptian version of Children's Health Locus of Control scale. J Egypt Public Health Assoc. 1999; 74(1-2):139-73." xsd:string
property_value: SCDO:0000340 "Deaux EB.  Health Locus of Control in Chukotka children. Alaska Med. 1992 Jul-Sep; 34(3):135-9." xsd:string
property_value: SCDO:0000340 "Parcel G.S. and Meyer M.P. (1978) Development of an instrument to measure children's health locus of control. Health Education Monographs, 6, 149-159." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Healthy Children; Children with Medical Conditions" xsd:string
property_value: SCDO:0000484 "English, Russian, a 9- item shorter Egyptian version" xsd:string
property_value: SCDO:0001033 "Has adequate reliability, construct validity and internal consistency." xsd:string
property_value: SCDO:0001222 "Children and Adolescents" xsd:string
property_value: SCDO:0001335 "no" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000222
name: Cholecystectomy
def: "Surgical removal of the gallbladder." []
synonym: "Cholecystectomies" EXACT []
xref: MESH:D002763
is_a: SCDO:0001129 ! Supportive Therapeutics
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D002763 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000222 xsd:string

[Term]
id: SCDO:0000225
name: Chronic Complications of Sickle Cell Disease
def: "A condition that co-exists or follows from sickle cell disease and that has a slow, creeping onset, slow progress and long continuance of disease manifestations." []
is_a: NCIT:C2959 ! Complication
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/Q000150 xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.obolibrary.org/obo/HP_0011010 xsd:string
property_value: SCDO:0000303 "Probably too specific to warrant inclusion into anther ontology." xsd:string
property_value: SCDO:0000303 "Used info in \"Evidence-Based Management of Sickle Cell Disease, Expert Panel Report, 2014\" to link to relevant phenotypes." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000226
name: Chronic Kidney Disease
def: "Chronic kidney disease (CKD) is defined as either having a glomerular filtration rate (GFR) of <60 mL/min/1.73 mL for >3 months with or without kidney damage or having evidence of kidney damage for 3 months, with or without decreased GFR." []
comment: Evidence of kidney damage includes pathologic abnormalities or markers of kidney damage (i.e., proteinuria) independent of cause. Kidney disease severity is classified into five stages according to the level of GFR and presence of albuminuria.
synonym: "Chronic Kidney Injury" EXACT []
synonym: "Chronic Renal Failure" EXACT []
synonym: "CKD" EXACT []
xref: DOID:784
is_a: HP:0000084 ! Kidney Failure
is_a: SCDO:0001334 ! Chronic Phenotype
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0001205 ! diagnosed using tool Urinary Albumin Test
relationship: SCDO:0000663 SCDO:0001206 ! diagnosed using tool Urinary Creatinine Test
relationship: SCDO:0000664 SCDO:0000067 ! treated with Antihypertensive Agents
relationship: SCDO:0000664 SCDO:0000983 ! treated with Renal Dialysis
relationship: SCDO:0000664 SCDO:0000985 ! treated with Renal Transplant
relationship: SCDO:1000220 CMO:0000057 ! diagnosed using measurement Serum Creatinine Level
relationship: SCDO:1000220 SCDO:0000310 ! diagnosed using measurement Blood Cystatin C Level
relationship: SCDO:1000220 SCDO:0000457 ! diagnosed using measurement Glomerular Filtration Rate
relationship: SCDO:1000220 SCDO:0001209 ! diagnosed using measurement Urine Albumin Concentration
relationship: SCDO:1000220 SCDO:0001210 ! diagnosed using measurement Urine Albumin Excretion Rate
relationship: SCDO:1000220 SCDO:0001212 ! diagnosed using measurement Urine Albumin-Creatinine Ratio
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "classification-of-chronic-kidney-disease-2"
property_value: http://purl.org/dc/elements/1.1/source "NHLBI SCD New guidelines 2014." xsd:string
property_value: SCDO:0000303 "Suggest update to description in DO (currently no definition)." xsd:string
property_value: SCDO:0000340 "NHLBI SCD New guidelines 2014." xsd:string
property_value: SCDO:0000468 "When assessed by albuminuria, often presents in second decade of life in sickle cell disease and prevalence increases with age." xsd:string
property_value: SCDO:0000472 "CKD is classified using a combination of GFR and ACR categories" xsd:string
property_value: SCDO:0000661 "Sickle cell disease, hypertension, diabetes, polycystic kidney disease, glomerulonephritis, various other causes." xsd:string
property_value: SCDO:0000662 "Reduced glomerular filtration, elevated creatinine, anemia, bone disease, uremia." xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000227
name: deprecated-Chronic Kidney Injury
def: "Is a long-term condition where the kidneys don't work as well as they should." []
synonym: "CKD" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000303 "There is conflicting positioning of this term in different ontologies. Need an expert to decide descriptions and positioning of this and related terms." xsd:string
is_obsolete: true
replaced_by: SCDO:0000226

[Term]
id: SCDO:0000228
name: Chronic Neuropathic Pain
def: "Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat." []
is_a: SCDO:0000233 ! Chronic Sickle Cell Pain
relationship: SCDO:0000664 NCIT:C62005 ! treated with Amitriptyline
relationship: SCDO:0000664 NCIT:C64625 ! treated with Pregabalin
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 EFO:0005762
property_value: SCDO:0000340 "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000229
name: Chronic Pain in a Specific Tissue or Organ
def: "This pain occurs in a specific tissue or organ and is usually described as constant and deep, nagging, and achy in nature." []
is_a: SCDO:0000233 ! Chronic Sickle Cell Pain
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000230
name: Chronic Pain often Unclear Etiology
def: "The only complaint is the patient's self-report of pain that does not go away." []
comment: This type of chronic sickle cell pain may be an extension of\nrecurrent acute painful episodes. Therefore, early and aggressive intervention in treating acute sickle cell\npain may reduce the development of chronic pain.
synonym: "Intractable Chronic Pain Without Obvious Pathology" EXACT []
is_a: SCDO:0000233 ! Chronic Sickle Cell Pain
property_value: http://purl.org/dc/elements/1.1/source "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:0000340 http://doi.org/10.1182/blood-2012-04-383430 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000232
name: Chronic Restrictive Lung Disease
def: "Restrictive lung disease is a category of extrapulmonary, pleural, or parenchymal respiratory diseases that restrict lung expansion, resulting in a decreased lung volume, an increased work of breathing, and inadequate ventilation and/or oxygenation. Pulmonary function test demonstrates a decrease in the forced vital capacity." []
synonym: "Chronic Restrictive Ventilatory Defect" EXACT []
synonym: "Restrictive Lung Disease" EXACT []
is_a: HP:0002086 ! Abnormality of the Respiratory System
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
is_a: SCDO:0001334 ! Chronic Phenotype
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "The description does not seem complete as it does not address the \"chronic\" aspect.\n\nRequest inclusion into relevant ontology\n\nWikipedia was used as the description source. Perhaps rather use NCIT's \"Restrictive Lung Disease\", and then use wikipedia as source for additional info. Did not find \"Chronic Restrictive Lung Disease\" in ontologies, but did find \"Chronic Obstructive Lung Disease\"...perhaps there was confusion between these terms when giving the name?" xsd:string
property_value: SCDO:0000340 HP:0002091
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000233
name: Chronic Sickle Cell Pain
def: "Persistent pain in sickle cell disease. In sickle cell disease, persistent pain (pain that has lasted longer than 3 to 6 months) no longer serves as a warning sign. However, the time distinction is arbitrary and the condition may be difficult to distinguish from frequently recurring acute pain. Chronic pain may occur with objective signs of avascular necrosis, arthropathy, arthritis, leg ulcers or vertebral body collapse, or without objective signs, due to neuroplasticity of the peripheral nervous system." []
synonym: "SCD-Associated Chronic Pain" EXACT []
is_a: HP:0012532 ! Chronic Pain
is_a: SCDO:0001023 ! SCD Related Pain
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 HP:0012532
property_value: SCDO:0000340 "SCD Management guidelines - Tanzania" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000234
name: Chronic Sickle Cell Pain Management
def: "Sickle cell pain management that aims to restore function and improve the quality of life." []
synonym: "Chronic Sickle Cell Pain Treatment" EXACT []
is_a: SCDO:0001052 ! Sickle Cell Pain Management
relationship: SCDO:1000015 SCDO:0000952 ! modifies Quality of Life in Sickle Cell Disease Measure
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into MESH below \"Pain Management\" / \"Sickle Cell Pain Management\" (also to be suggested for inclusion)" xsd:string
property_value: SCDO:0000340 SCDO:1000152
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000235
name: Cigarette Smoking Status
def: "An indication of a person's current cigarette use as well as some indication of cigarette smoking history." []
synonym: "Cigarette Smoking Status Measurement" EXACT []
is_a: NCIT:C29719 ! Smoking History
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:1000320 ! obtained via diagnostic tool Cigarette Smoking Status Diagnostic Instrument - Adult
relationship: SCDO:1000190 SCDO:1000321 ! obtained via diagnostic tool Cigarette Smoking Status Diagnostic Instrument - Adolescent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://bioportal.bioontology.org/ontologies/ROO?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C19796
property_value: SCDO:0000303 "Request inclusion below \"smoking status\" in Exposure Ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000236
name: Climate
def: "Meteorological conditions, including temperature, precipitation, and wind, that characteristically prevail in a particular region; includes regions of the earth having particular meteorological conditions." []
xref: CRISP:1035-6799
is_a: SCDO:0000897 ! Physical Environment
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/CRISP?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FCSP%2F1035-6799 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000236 xsd:string

[Term]
id: SCDO:0000245
name: Clinical Coding
def: "Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)" []
synonym: "Coding" EXACT []
synonym: "Medical Coding" EXACT []
xref: MESH:D059019
is_a: SCDO:0000738 ! Medical Records
property_value: SCDO:0000303 "Add specific Sickle Cell Disease related codes as instances/individuals below *Clinical Coding*? (see ICD-10 codes here: www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-)" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D059019 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000245 xsd:string

[Term]
id: SCDO:0000246
name: Clinical Competence
def: "The capability to perform acceptably those duties directly related to patient care." []
synonym: "Clinical Competencies" EXACT []
synonym: "Clinical Competency" EXACT []
synonym: "Clinical Skill" EXACT []
synonym: "Competencies, Clinical" EXACT []
synonym: "Competency, Clinical" EXACT []
synonym: "Skill, Clinical" EXACT []
synonym: "Skills, Clinical" EXACT []
xref: MESH:D002983
is_a: SCDO:0000948 ! Quality of Health Care
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D002983 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000246 xsd:string

[Term]
id: SCDO:0000247
name: obsolete Clinical Conference
def: "'Work that consists of a conference of physicians on their observations of a patient at the bedside, regarding the physical state, laboratory and other diagnostic findings, clinical manifestations, results of current therapy, etc. A clinical conference usually ends with a confirmation or correction of clinical findings by a pathological diagnosis performed by a pathologist. Clinical conference is often referred to as a clinico-pathological conference. [Curator team: []]'" []
synonym: "Clinico-Pathologic Conference" EXACT []
synonym: "Clinico-Pathological Conference" EXACT []
xref: MESH:D016429
is_a: SCDO:0000941 ! obsolete Publication Type
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016429 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000249
name: obsolete Clinical Diagnostic Questionnaire
def: "'A quick and accurate way of assessing the patient health states using well defined set of questions and analyzed for an optimal clinical decision for the patient. [Curator team: Gaston K. Mazandu]'" []
is_a: SCDO:0000957 ! obsolete Questionnaire
is_obsolete: true

[Term]
id: SCDO:0000250
name: Clinical Neuropathy Assessment
def: "A physician administered examination to assess peripheral neuropathy." []
synonym: "Charcot-Marie-Tooth Neuropathy Score" EXACT []
synonym: "Neuropathy - Clinical Assessment" EXACT []
xref: phenX:130201
is_a: SCDO:0000898 ! Physical Examination
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/130201
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/130201
property_value: SCDO:0000479 "PhenX protocol: Neuropathy - Clinical Assessment #130201" xsd:string
property_value: SCDO:0000486 "Can be used to assess the severity of symptoms and disability associated with peripheral neuropathy caused by a number of disorders including tumors, infections, autoimmune diseases, and inherited disorders such as Charcot-Marie-Tooth disease." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000250 xsd:string

[Term]
id: SCDO:0000251
name: Clinical Phenotype of Beta Thalassemia
def: "Abnormal clinical manifestations of beta thalassemia that are as a result of the underlying genotype." []
is_a: SCDO:0000111 ! Beta Thalassemia
relationship: SCDO:1000005 HP:0011904 ! modified by Increased Hemoglobin F
relationship: SCDO:1000005 SCDO:0000042 ! modified by Alpha Thalassemia
relationship: SCDO:1000005 SCDO:0000580 ! modified by Hydroxyurea
relationship: SCDO:1000005 SCDO:1000707 ! modified by Hemoglobin F Level
relationship: SCDO:1000172 SCDO:0007624 ! has causal genotype Beta Thalassemia Genotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Could this not rather be \"Clinical Subtype of Beta Thalassemia\"? See \"clinical subtype\" in Orphanet." xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000252
name: obsolete Clinical Study
def: "'A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'" []
xref: MESH:D000068397
is_a: SCDO:0000941 ! obsolete Publication Type
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000068397 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000253
name: Clinical Studies as Topic
def: "Works about research studies that evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies." []
xref: MESH:D000068456
is_a: SCDO:0300004 ! Epidemiologic Study Characteristics
property_value: SCDO:0000303 "Term to be adapted as necessary to match EDDA Study Designs Taxonomy" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000068456 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000253 xsd:string

[Term]
id: SCDO:0000254
name: obsolete Clinical Trial
def: "'A work that reports on the results of a clinical study in which participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Participants may receive diagnostic, therapeutic, or other types of interventions. While most clinical trials concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'" []
synonym: "Intervention Study" EXACT []
xref: MESH:D016430
is_a: SCDO:0000252 ! obsolete Clinical Study
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016430 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000255
name: obsolete Clinical Trial, Phase I
def: "'Work that is the report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on a small number of healthy persons and conducted over the period of about a year in either the United States or a foreign country. [Curator team: []]'" []
synonym: "Clinical Trial, Phase 1" EXACT []
xref: MESH:D017426
is_a: SCDO:0000254 ! obsolete Clinical Trial
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017426 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000256
name: obsolete Clinical Trial, Phase II
def: "'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on several hundred volunteers, including a limited number of patients, and conducted over a period of about two years in either the United States or a foreign country. [Curator team: []]'" []
synonym: "Clinical Trial, Phase 2" EXACT []
xref: MESH:D017427
is_a: SCDO:0000254 ! obsolete Clinical Trial
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017427 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000257
name: obsolete Clinical Trial, Phase IV
def: "'Work that is a report of a planned post-marketing study of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale after clinical trials, phases I, II, and III. These studies, conducted in the United States or a foreign country, often garner additional data about the safety and efficacy of a product. [Curator team: []]'" []
synonym: "Clinical Trial, Phase 4" EXACT []
xref: MESH:D017429
is_a: SCDO:0000254 ! obsolete Clinical Trial
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017429 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000258
name: obsolete Clinical Trial, Phase III
def: "'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques after phase II trials. A large enough group of patients is studied and closely monitored by physicians for adverse response to long-term exposure, over a period of about three years in either the United States or a foreign country. [Curator team: []]'" []
synonym: "Clinical Trial, Phase 3" EXACT []
xref: MESH:D017428
is_a: SCDO:0000254 ! obsolete Clinical Trial
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017428 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000259
name: Clinical Trials as Topic
def: "Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries." []
xref: MESH:D002986
is_a: SCDO:0000253 ! Clinical Studies as Topic
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D002986 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000259 xsd:string

[Term]
id: SCDO:0000262
name: Cognitive Therapy
def: "A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior." []
synonym: "CBT" EXACT []
synonym: "Cognition Therapies" EXACT []
synonym: "Cognition Therapy" EXACT []
synonym: "Cognitive Behavioral Therapies" EXACT []
synonym: "Cognitive Behavioral Therapy" EXACT []
synonym: "Cognitive Behaviour Therapy" EXACT []
synonym: "Cognitive Psychotherapies" EXACT []
synonym: "Cognitive Psychotherapy" EXACT []
synonym: "Cognitive Therapies" EXACT []
xref: MESH:D015928
is_a: SCDO:0001284 ! Behaviour Therapy
relationship: SCDO:1000018 SCDO:0000465 ! treats Growth Delay
relationship: SCDO:1000018 SYMP:0019161 ! treats Muscle Pain
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D015928 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000262 xsd:string

[Term]
id: SCDO:0000263
name: Cohort Studies
def: "Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics." []
synonym: "Cohort Analyses" EXACT []
xref: MESH:D015331
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D015331 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000263 xsd:string

[Term]
id: SCDO:0000265
name: Coma
def: "A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem reticular formation." []
synonym: "Comas" EXACT []
xref: MESH:D003128
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000663 NCIT:C16809 ! diagnosed using tool Magnetic Resonance Imaging
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0000139 ! diagnosed using tool Blood Culture
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "The specific type of Blood Test (s) used to diagnose a coma should be specified. --  -- Named Individual removed (is diagnosed by): -- As in any neurologic condition, history and examination form the cornerstone of diagnosis when the patient is in a coma; however, history must be obtained from family, friends, or EMS. The Glasgow Coma Scale is a system of examining a comatose patient. It is helpful for evaluating the depth of the coma, tracking the patient's progress, and predicting (somewhat) the ultimate outcome of the coma. The Glasgow Coma Scale assigns a different number of points for exam results in three different categories: opening the eyes, verbal response (using words or voice to respond), and motor response (moving a part of the body). Fifteen is the largest possible number of total points, indicating the highest level of functioning. The highest level of functioning would be demonstrated by an individual who spontaneously opens his/her eyes, gives appropriate answers to questions about his/her situation, and can carry out a command (such as \"move your leg\" or \"nod your head\"). Three is the least possible number of total points and would be given to a patient for whom not even a painful stimulus is sufficient to provoke a response. In the middle are those patients who may be able to respond, but who require an intense or painful stimulus, and whose response may demonstrate some degree of brain malfunctioning (such as a person whose only response to pain in a limb is to bend that limb in toward the body). When performed as part of the admission examination, a Glasgow score of three to five points often suggests that the patient has likely suffered fatal brain damage, while eight or more points indicates that the patient's chances for recovery are good. Expansion of the pupils and respiratory pattern are also important. Metabolic causes of coma are diagnosed from blood work and urinalysis to evaluate blood chemistry, drug screen, and blood cell abnormalities that may indicate infection. Anatomic causes of coma are diagnosed from CT (computed tomography) or MRI (magnetic resonance imaging) scans." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003128 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000265 xsd:string

[Term]
id: SCDO:0000267
name: Comorbid Disease
def: "A co-existing or additional disease with reference to an initial diagnosis or with reference to the index condition that is the subject of study." []
synonym: "Additional Disease" EXACT []
synonym: "Co-Existing Disease" EXACT []
synonym: "Co-Morbid Condition" EXACT []
synonym: "Co-Morbid Disease" EXACT []
is_a: DOID:4 ! Disease
is_a: OGMS:0000023 ! Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/D015897
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nAs per: \"Transition and Sickle Cell Disease\" by Michael R. DeBaun, Joseph Telfair -- Include here: -- Asthma -- Osteonecrosis of the Femoral Head -- Restrictive Lung Disease (currently Chronic Restrictive Lung Disease in SCDO) -- Retinopathy -- Cardiac Dysfunction -- Renal Dysfunction/Renal Failure --  -- ...and others" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000268
name: Comparative Study
def: "Comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs." []
synonym: "Comparative Studies" EXACT []
xref: MESH:D003160
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003160 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000268 xsd:string

[Term]
id: SCDO:0000271
name: Complementary Therapy
def: "Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (physical therapy modalities; diet; acupuncture) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment. Year introduced: 2002(1986)." []
synonym: "Complementary Medicine" EXACT []
xref: MESH:D000529
is_a: SCDO:0001152 ! Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000529 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000271 xsd:string

[Term]
id: SCDO:0000272
name: obsolete Compound Heterozygous Hemoglobinopathy
def: "'Compound heterozygosity in medical genetics is the condition of having two heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state. [Curator team: []]'" []
is_a: SCDO:0001336 ! from phenotype
is_obsolete: true

[Term]
id: SCDO:0000276
name: Conjunctival Comma Sign
def: "Dark red, comma- or corkscrew-shaped vascular fragment that appears to be isolated from neighboring blood vessels in the conjunctiva. Normally benign, this lesion can serve as the first diagnostic sign of sickle cell retinopathy. The conjunctival comma sign results from transient vaso-occlusive processes in the microvasculature of bulbar conjunctiva. It is not seen in sickle trait, but is common in SCD." []
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:0000663 NCIT:C75583 ! diagnosed using tool Slit-Lamp Examination
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 "Ballas et al 2010 Am J Hematol" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000277
name: obsolete Consensus Development Conference
def: "'A work that consists of summary statements representing the majority and current agreement of physicians, scientists, and other professionals meeting to reach a consensus on a selected subject. [Curator team: []]'" []
xref: MESH:D016446
is_a: SCDO:0000941 ! obsolete Publication Type
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016446 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000278
name: obsolete Consensus Development Conference, NIH
def: "'Work consisting of summary statements, from a conference sponsored by NIH, representing the majority of current opinion of physicians, scientists, and other professionals on a selected subject. [Curator team: []]'" []
synonym: "NIH Consensus Development Conference" EXACT []
xref: MESH:D016447
is_a: SCDO:0000277 ! obsolete Consensus Development Conference
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016447 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000280
name: Consumer Assessment of Healthcare Providers and Systems (CAHPS) Health Plan Survey 4.0 Child Medicaid Questionnaire
def: "A tool for collecting standardized information on enrollees' experiences with health plans and their services." []
comment: This measure includes general questions about access to care and quality of care and additional questions about the services provided to children with chronic conditions. Items CC1-CC38 of the questionnaire are version 4.0 of the Children with Chronic Conditions Item Set.
xref: PhenX:820102
is_a: SCDO:0000947 ! Quality of Care Measure
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/820102
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/820102
property_value: SCDO:0000479 "PhenX protocol: Quality of Care - Children #820102" xsd:string
property_value: SCDO:0000481 "Proxy (Primary caregiver)" xsd:string
property_value: SCDO:0000486 "Used to assess the patient-reported health care needs and quality of service from health care providers for individuals with chronic conditions such as sickle cell disease (SCD)." xsd:string
property_value: SCDO:0001222 "Children and adolescents, ages 17 and younger" xsd:string
property_value: SCDO:0001335 "yes" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000282
name: Controlled Pre-Post Studies
def: "A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not." []
synonym: "Controlled Before-After Studies" EXACT []
xref: MESH:D065187
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D065187 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000282 xsd:string

[Term]
id: SCDO:0000283
name: obsolete Controlled Clinical Trial
def: "'A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterized as a randomized controlled trial. [Curator team: []]'" []
xref: MESH:D018848
is_a: SCDO:0000254 ! obsolete Clinical Trial
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018848 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000284
name: Controlled Clinical Trials as Topic
def: "Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as randomized controlled trials as topic." []
xref: MESH:D018849
is_a: SCDO:0000259 ! Clinical Trials as Topic
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018849 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000284 xsd:string

[Term]
id: SCDO:0000286
name: Coping Skill
def: "A state of harmony between internal needs and external demands and the processes used in achieving this condition." []
synonym: "Adaptive Behavior" EXACT []
synonym: "Adaptive Behaviors" EXACT []
synonym: "Coping Behavior" EXACT []
synonym: "Coping Behaviors" EXACT []
synonym: "Coping Skills" EXACT []
synonym: "Psychologic Adaptation" EXACT []
synonym: "Psychological Adaptation" EXACT []
xref: MESH:D000223
is_a: SCDO:0000746 ! Mental Health
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000223 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000286 xsd:string

[Term]
id: SCDO:0000287
name: Coping Strategies Questionnaire revised for Sickle Cell Disease (CSQ-SCD)
def: "The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely." []
synonym: "Coping Strategies Questionnaire revised for Sickle Cell Disease" EXACT []
synonym: "CSQ-SCD" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "Gil K.M., Abrams M.R., Phillips G. and Keefe F.J. (1989). Sickle cell disease pain: Relation of coping strategies to adjustment. Journal of Consulting and Clinical Psychology, 57, 725-731." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Abrams M.R., Phillips G. and Keefe F.J. (1989). Sickle cell disease pain: Relation of coping strategies" xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Adults with SCD" xsd:string
property_value: SCDO:0001033 "Demonstrated validity with SCD populations USA and UK; several publications." xsd:string
property_value: SCDO:0001222 "Adults" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000288
name: Coping Strategies Questionnaire revised for Sickle Cell Disease Children (CSQ-SCD Children)
def: "The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely." []
synonym: "CSQ-SCD Children" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "Gil K.M., Williams D.A., Thompson, R.J. and Kinney, T.R. (1991). Sickle cell disease in children and adolescents: The relation of child and parent pain coping strategies to adjustment. Journal of Pediatric Psychology, 16, 643-663." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Gil K.M., Williams D.A., Thompson, R.J. and Kinney, T.R. (1991). Sickle cell disease in children and adolescents: The relation of child and parent pain coping strategies to adjustment. Journal of Pediatric Psychology, 16, 643-663." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Children with SCD" xsd:string
property_value: SCDO:0001033 "Demonstrated validity with SCD populations USA and UK; several publications." xsd:string
property_value: SCDO:0001222 "Children" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000291
name: Corticosteroid-Induced Adverse Event
def: "A causal adverse drug event that is induced by a corticosteroid." []
is_a: SCDO:0000191 ! Causal Adverse Drug Event
relationship: SCDO:1000199 CHEBI:50858 ! induced by Corticosteroid
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.sciencedirect.com/science/article/pii/S1526054213001218
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/18717146
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/19331266
property_value: SCDO:0000303 "Request inclusion into OAE below \"Causal Adverse Drug Event\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000292
name: Corticosteroid-Induced Vaso-Occlusive Adverse Event
def: "A corticosteroid-induced adverse event that has the outcome of vaso-occlusion." []
is_a: SCDO:0000291 ! Corticosteroid-Induced Adverse Event
relationship: SCDO:1000199 CHEBI:50858 ! induced by Corticosteroid
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/18717146
property_value: SCDO:0000303 "Request inclusion into OAE below \"Corticosteroid-Induced Adverse Event\" (also suggested by us for inclusion)." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000294
name: Cost of Illness
def: "The personal cost of disease which may be economic, social, or psychological. The cost of illness may be reflected in absenteeism, productivity, response to treatment, peace of mind, or quality of life. It differs from health care costs, the societal cost of providing services related to the delivery of health care." []
synonym: "Burden of Illness" EXACT []
synonym: "Cost of Disease" EXACT []
synonym: "Cost of Sickness" EXACT []
synonym: "Costs of Disease" EXACT []
synonym: "Disease Cost" EXACT []
synonym: "Disease Costs" EXACT []
synonym: "Economic Burden of Disease" EXACT []
synonym: "Sickness Cost" EXACT []
xref: MESH:D017281
is_a: SCDO:0000496 ! Healthcare Access
is_a: SCDO:0000746 ! Mental Health
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017281 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000294 xsd:string

[Term]
id: SCDO:0000295
name: Cost-Effectiveness of Healthcare
def: "The extent to which a health intervention can be regarded as providing value for money, based on a cost-effectiveness analysis that compares the costs and health effects of the intervention. This informs decision-makers who have to determine where to allocate limited healthcare resources." []
synonym: "Health Care Economics" EXACT []
synonym: "Health Economics" EXACT []
is_a: SCDO:0000495 ! Health Utility
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly into MESH, perhaps in an appropriate place below \"Quality of Health Care\"." xsd:string
property_value: SCDO:0000340 http://www.medicine.ox.ac.uk/bandolier/painres/download/whatis/Cost-effect.pdf xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000296
name: Creatinine Blood Test
def: "A bioassay to measure the serum concentration of creatinine, a metabolite of muscle creatine that is filtered out of blood by the kidneys." []
synonym: "Blood Creatinine Assay" EXACT []
synonym: "Blood Creatinine Test" EXACT []
synonym: "Serum Creatinine" EXACT []
synonym: "Serum Creatinine Assay" EXACT []
xref: phenX:141400
is_a: SCDO:0000133 ! Blood Test
is_a: SCDO:0000676 ! Kidney Function Test
relationship: SCDO:0001297 CMO:0000057 ! has essential measure Serum Creatinine Level
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000567 ! has essential measure History of Kidney Failure Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000570 ! has essential measure History of Type I and Type 2 Diabetes Diagnostic Instrument
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/141401
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000296 xsd:string

[Term]
id: SCDO:0000297
name: Crisis Intervention
def: "Brief therapeutic approach which is ameliorative rather than curative of acute psychiatric emergencies. Used in contexts such as emergency rooms of psychiatric or general hospitals, or in the home or place of crisis occurrence, this treatment approach focuses on interpersonal and intrapsychic factors and environmental modification. (APA Thesaurus of Psychological Index Terms, 7th ed)" []
synonym: "Crisis Interventions" EXACT []
synonym: "Interventions, Crisis" EXACT []
xref: MESH:D003419
is_a: SCDO:0000940 ! Psychotherapy
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003419 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000297 xsd:string

[Term]
id: SCDO:0000298
name: Cross-Sectional Studies
def: "Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with longitudinal studies which are followed over a period of time." []
synonym: "Cross-Sectional Analysis" EXACT []
synonym: "Cross-Sectional Study" EXACT []
xref: MESH:D003430
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003430 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000298 xsd:string

[Term]
id: SCDO:0000299
name: Culture
def: "A collective expression for all behaviour patterns acquired and socially transmitted through symbols. Culture includes customs, traditions, and language." []
synonym: "Cultural Beliefs" EXACT []
synonym: "Cultural Values" EXACT []
xref: MESH:D003469
is_a: NCIT:C17047 ! Quality of Life
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003469 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000299 xsd:string

[Term]
id: SCDO:0000301
name: Curative Therapeutics
def: "Therapeutics relating to or used in the cure of diseases." []
is_a: SCDO:0001152 ! Therapeutics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.merriam-webster.com/dictionary/curative xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000304
name: Current Age
def: "The length of time that a person has lived since their birth up until the current day." []
synonym: "Current Chronological Age" EXACT []
is_a: NCIT:C25150 ! Age
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but available definitions not adequate" xsd:string

[Term]
id: SCDO:0000305
name: Current Educational Attainment
def: "The respondent's highest level of education at the current time." []
synonym: "Educational Attainment" EXACT []
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0000414 ! Education
is_a: SCDO:0001090 ! Socioeconomic Factors
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 SCDO:0000056 ! has essential measure Annual Family Income
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Request inclusion into MESH below \"Socioeconomic Factors\"." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/11001
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000306
name: Current Employment Status
def: "The respondent's current employment status." []
synonym: "Employment Status" EXACT []
xref: phenX:11301
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0001090 ! Socioeconomic Factors
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/11301
property_value: SCDO:0000479 "PhenX protocol: Current Employment Status #11301" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000306 xsd:string

[Term]
id: SCDO:0000307
name: Current Marital Status
def: "The respondent's current marital status." []
synonym: "Marital or Partnership Status" EXACT []
synonym: "Marital Status" EXACT []
xref: phenX:10902
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0001090 ! Socioeconomic Factors
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Can add sub-classes of \"Marital Status\" from MESH." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/10902
property_value: SCDO:0000479 "PhenX protocol: Current Marital Status #10902" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000307 xsd:string

[Term]
id: SCDO:0000310
name: Blood Cystatin C Level
def: "The amount of the protein cystatin C (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide) found in a specified sample of blood. This extracellular cystatin subtype is abundantly expressed in bodily fluids." []
synonym: "Blood CC Level" EXACT []
synonym: "Blood Cst3 Level" RELATED []
synonym: "Cystatin 3 Level" EXACT []
synonym: "Gamma Trace Level" EXACT []
synonym: "Gamma-Trace Level" EXACT []
synonym: "Neuroendocrine Basic Polypeptide Level" EXACT []
synonym: "Post Gamma Globulin Level" EXACT []
synonym: "Post-Gamma-Globulin Level" EXACT []
xref: CMO:0002777
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1000190 SCDO:1000310 ! obtained via diagnostic tool Cystatin C Blood Test
property_value: http://purl.org/dc/elements/1.1/source http://www.revespcardiol.org/en/cystatin-c-and-cardiovascular-risk/articulo/13149959/
property_value: SCDO:0000303 "This class is used as a biomarker of kidney function and kidney disease." xsd:string
property_value: SCDO:0000340 CMO:0002777
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055316 xsd:string
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_0004617 xsd:string
property_value: SCDO:1000288 "Suggest update to description in CMO" xsd:string

[Term]
id: SCDO:0000311
name: D57 Sickle-Cell Disorders
def: "A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia." []
synonym: "D57" EXACT []
xref: ICD10CM:D57
is_a: SCDO:0000607 ! ICD-10-CM Diagnosis Codes
property_value: SCDO:0000340 http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57- xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000311 xsd:string

[Term]
id: SCDO:0000312
name: D57.0 Hb-SS disease with crisis
def: "Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis." []
synonym: "D57.0" EXACT []
synonym: "Hb-SS disease with vasoocclusive pain" EXACT []
synonym: "Sickle cell anemia with crisis" EXACT []
synonym: "Sickle cell anemia with vasoocclusive pain" EXACT []
xref: ICD10CM:D57.0
is_a: SCDO:0000311 ! D57 Sickle-Cell Disorders
relationship: SCDO:1000785 NCIT:C131682 ! code requires phenotype Sickle Cell Disease-SS
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: SCDO:0000340 http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.0 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000312 xsd:string

[Term]
id: SCDO:0000313
name: D57.01 Hb-SS disease with acute chest syndrome
def: "-" []
synonym: "D57.01" EXACT []
synonym: "Hb-SS disease with acute chest syndrome" EXACT []
synonym: "Sickle cell anemia with acute chest syndrome" EXACT []
synonym: "Sickle cell anemia, acute chest syndrome" EXACT []
xref: ICD10CM:D57.01
is_a: SCDO:0000312 ! D57.0 Hb-SS disease with crisis
relationship: SCDO:1000785 DOID:1584 ! code requires phenotype Acute Chest Syndrome
relationship: SCDO:1000785 NCIT:C131682 ! code requires phenotype Sickle Cell Disease-SS
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.01 xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:0000314
name: D57.02 Hb-SS disease with splenic sequestration
def: "-" []
synonym: "Acute sickle cell splenic sequestration crisis" EXACT []
synonym: "D57.02" EXACT []
synonym: "Hb-SS disease with splenic sequestration" EXACT []
synonym: "Sickle cell anemia acute crisis splenic sequestration" EXACT []
xref: ICD10CM:D57.02
is_a: SCDO:0000312 ! D57.0 Hb-SS disease with crisis
relationship: SCDO:1000785 NCIT:C131682 ! code requires phenotype Sickle Cell Disease-SS
relationship: SCDO:1000785 SCDO:0007161 ! code requires phenotype Acute Splenic Sequestration Crisis
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.02 xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:0000315
name: D57.1 Sickle-cell disease without crisis
def: "-" []
synonym: "D57.1" EXACT []
synonym: "Sickle cell anemia without crisis" EXACT []
synonym: "Sickle-cell disease without crisis" EXACT []
xref: ICD10CM:D57.1
is_a: SCDO:0000311 ! D57 Sickle-Cell Disorders
relationship: SCDO:1000785 NCIT:C131682 ! code requires phenotype Sickle Cell Disease-SS
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.1 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000316
name: D57.2 Sickle-cell/Hb-C disease
def: "One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c. It is similar to, but less severe than sickle cell anemia." []
synonym: "D57.2" EXACT []
xref: ICD10CM:D57.2
is_a: SCDO:0000311 ! D57 Sickle-Cell Disorders
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
property_value: SCDO:0000340 http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.2 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000316 xsd:string

[Term]
id: SCDO:0000317
name: D57.20 Sickle-cell/Hb-C disease without crisis
def: "-" []
synonym: "D57.20" EXACT []
synonym: "Sickle Cell Disease-SC without crisis" EXACT []
synonym: "Sickle-cell/Hb-C disease without crisis" EXACT []
xref: ICD10CM:D57.20
is_a: SCDO:0000316 ! D57.2 Sickle-cell/Hb-C disease
relationship: SCDO:1000785 NCIT:C3833 ! code requires phenotype Asymptomatic
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.20 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000318
name: D57.21 Sickle-cell/Hb-C disease with crisis
def: "-" []
synonym: "D57.21" EXACT []
synonym: "Sickle Cell Disease-SC with crisis" EXACT []
synonym: "Sickle-cell/Hb-C disease with crisis" EXACT []
xref: ICD10CM:D57.21
is_a: SCDO:0000316 ! D57.2 Sickle-cell/Hb-C disease
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.21 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000319
name: D57.211 Sickle-cell/Hb-C disease with acute chest syndrome
def: "-" []
synonym: "Acute chest syndrome due to sickle cell-hemoglobin c disease crisis" EXACT []
synonym: "Acute chest syndrome sickle cell hb-c crisis" EXACT []
synonym: "D57.211" EXACT []
synonym: "Sickle Cell Disease-SC with acute chest syndrome" EXACT []
synonym: "Sickle-cell/Hb-C disease with acute chest syndrome" EXACT []
xref: ICD10CM:D57.211
is_a: SCDO:0000318 ! D57.21 Sickle-cell/Hb-C disease with crisis
relationship: SCDO:1000785 DOID:1584 ! code requires phenotype Acute Chest Syndrome
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.211 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000320
name: D57.212 Sickle-cell/Hb-C disease with splenic sequestration
def: "-" []
synonym: "D57.212" EXACT []
synonym: "Sickle Cell Disease-SC with splenic sequestration" EXACT []
synonym: "Sickle-cell/Hb-C disease with splenic sequestration" EXACT []
xref: ICD10CM:D57.212
is_a: SCDO:0000318 ! D57.21 Sickle-cell/Hb-C disease with crisis
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
relationship: SCDO:1000785 SCDO:0007161 ! code requires phenotype Acute Splenic Sequestration Crisis
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.212 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000321
name: D57.219 Sickle-cell/Hb-C disease with crisis, unspecified
def: "-" []
synonym: "D57.219" EXACT []
synonym: "Sickle Cell Disease-SC with crisis NOS" EXACT []
synonym: "Sickle Cell Disease-SC with crisis, unspecified" EXACT []
synonym: "Sickle Cell Disease-SC with vasoocclusive pain NOS" EXACT []
synonym: "Sickle cell-hemoglobin c disease with crisis" EXACT []
synonym: "Sickle-cell/Hb-C disease with crisis NOS" EXACT []
synonym: "Sickle-cell/Hb-C disease with crisis, unspecified" EXACT []
synonym: "Sickle-cell/Hb-C disease with vasoocclusive pain NOS" EXACT []
xref: ICD10CM:D57.219
is_a: SCDO:0000318 ! D57.21 Sickle-cell/Hb-C disease with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.219 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000322
name: D57.3 Sickle-cell trait
def: "The condition of being heterozygous for hemoglobin S." []
synonym: "D57.3" EXACT []
xref: ICD10CM:D57.3
is_a: SCDO:0000311 ! D57 Sickle-Cell Disorders
relationship: SCDO:1000785 SCDO:0001055 ! code requires phenotype Sickle Cell Trait
property_value: SCDO:0000340 http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.3 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000322 xsd:string

[Term]
id: SCDO:0000323
name: D57.4 Sickle-cell thalassemia
def: "Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene." []
synonym: "D57.4" EXACT []
xref: ICD10CM:D57.4
is_a: SCDO:0000311 ! D57 Sickle-Cell Disorders
relationship: SCDO:1000785 SCDO:0007656 ! code requires phenotype Sickle Cell Thalassemia
property_value: SCDO:0000340 http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.4 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000323 xsd:string

[Term]
id: SCDO:0000324
name: D57.40 Sickle-cell thalassemia without crisis
def: "-" []
synonym: "D57.40" EXACT []
xref: ICD10CM:D57.40
is_a: SCDO:0000323 ! D57.4 Sickle-cell thalassemia
relationship: SCDO:1000785 NCIT:C3833 ! code requires phenotype Asymptomatic
relationship: SCDO:1000785 NCIT:C95539 ! code requires phenotype Sickle Beta Thalassemia
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.40 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000325
name: D57.41 Sickle-cell thalassemia, unspecified, with crisis
def: "-" []
synonym: "D57.41" EXACT []
synonym: "Sickle-cell thalassemia with (painful) crisis" EXACT []
synonym: "Sickle-cell thalassemia with crisis" EXACT []
synonym: "Sickle-cell thalassemia with vasoocclusive pain" EXACT []
xref: ICD10CM:D57.41
is_a: SCDO:0000323 ! D57.4 Sickle-cell thalassemia
relationship: SCDO:1000785 NCIT:C95539 ! code requires phenotype Sickle Beta Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.41 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000326
name: D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome
def: "-" []
synonym: "D57.411" EXACT []
synonym: "Sickle-cell thalassemia, unspecified, with acute chest syndrome" EXACT []
xref: ICD10CM:D57.411
is_a: SCDO:0000325 ! D57.41 Sickle-cell thalassemia, unspecified, with crisis
relationship: SCDO:1000785 DOID:1584 ! code requires phenotype Acute Chest Syndrome
relationship: SCDO:1000785 NCIT:C95539 ! code requires phenotype Sickle Beta Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.411 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000327
name: D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration
def: "-" []
synonym: "D57.412" EXACT []
synonym: "Sickle cell thalassemia with splenic sequestration" EXACT []
synonym: "Sickle-cell thalassemia, unspecified, with splenic sequestration" EXACT []
xref: ICD10CM:D57.412
is_a: SCDO:0000325 ! D57.41 Sickle-cell thalassemia, unspecified, with crisis
relationship: SCDO:1000785 NCIT:C95539 ! code requires phenotype Sickle Beta Thalassemia
relationship: SCDO:1000785 SCDO:0007161 ! code requires phenotype Acute Splenic Sequestration Crisis
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.412 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000328
name: D57.419 Sickle-cell thalassemia, unspecified, with crisis
def: "-" []
synonym: "D57.419" EXACT []
synonym: "Sickle-cell thalassemia with (painful) crisis NOS" EXACT []
synonym: "Sickle-cell thalassemia with vasoocclusive pain NOS" EXACT []
synonym: "Sickle-cell thalassemia, unspecified, with crisis" EXACT []
xref: ICD10CM:D57.419
is_a: SCDO:0000325 ! D57.41 Sickle-cell thalassemia, unspecified, with crisis
relationship: SCDO:1000785 NCIT:C95539 ! code requires phenotype Sickle Beta Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.419 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000329
name: D57.8 Other sickle-cell disorders
def: "-" []
synonym: "D57.8" EXACT []
synonym: "Other sickle-cell disorders" EXACT []
xref: ICD10CM:D57.8
is_a: SCDO:0000311 ! D57 Sickle-Cell Disorders
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.8 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000330
name: D57.80 Other sickle-cell disorders without crisis
def: "-" []
synonym: "D57.80" EXACT []
xref: ICD10CM:D57.80
is_a: SCDO:0000329 ! D57.8 Other sickle-cell disorders
relationship: SCDO:1000785 NCIT:C3833 ! code requires phenotype Asymptomatic
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.80 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000331
name: D57.81 Other sickle-cell disorders with crisis
def: "-" []
synonym: "D57.81" EXACT []
xref: ICD10CM:D57.81
is_a: SCDO:0000329 ! D57.8 Other sickle-cell disorders
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.81 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000332
name: D57.811 Other sickle-cell disorders with acute chest syndrome
def: "-" []
synonym: "D57.811" EXACT []
xref: ICD10CM:D57.811
is_a: SCDO:0000331 ! D57.81 Other sickle-cell disorders with crisis
relationship: SCDO:1000785 DOID:1584 ! code requires phenotype Acute Chest Syndrome
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.811 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000333
name: D57.812 Other sickle-cell disorders with splenic sequestration
def: "-" []
synonym: "D57.812" EXACT []
xref: ICD10CM:D57.812
is_a: SCDO:0000331 ! D57.81 Other sickle-cell disorders with crisis
relationship: SCDO:1000785 SCDO:0007161 ! code requires phenotype Acute Splenic Sequestration Crisis
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.812 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000334
name: D57.819 Other sickle-cell disorders with crisis, unspecified
def: "-" []
synonym: "D57.819" EXACT []
xref: ICD10CM:D57.819
is_a: SCDO:0000331 ! D57.81 Other sickle-cell disorders with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.819 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000338
name: obsolete Protein Molecule
def: "'Protein molecule are large, complex molecules that play many critical roles in the body. They do most of the work in cells and are required for the structure, function, and regulation of the body's tissues and organs. [Curator team: []]'" []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000340 https://ghr.nlm.nih.gov/primer/howgeneswork/protein xsd:string
is_obsolete: true

[Term]
id: SCDO:0000343
name: Delta Beta Thalassemia
def: "A form of beta-thalassemia characterized by decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis." []
synonym: "Delta Beta Thalassaemia" EXACT []
synonym: "Delta-Beta-Thalassaemia" EXACT []
synonym: "Delta-Beta-Thalassemia" EXACT []
synonym: "F Thalassaemia" EXACT []
xref: ORPHA:231237
is_a: SCDO:0000111 ! Beta Thalassemia
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:0005671 ! has causal genotype HBB and HBD Deletion
relationship: SCDO:1000210 SCDO:0005671 ! has causal or contributing genetic variation HBB and HBD Deletion
relationship: SCDO:1000210 SCDO:1000209 ! has causal or contributing genetic variation Crossover between delta (HBD) and beta globin (HBB) gene loci
relationship: SCDO:1000223 SCDO:0000976 ! has causal molecular phenotype Reduced Hemoglobin A
property_value: SCDO:0000340 Orphanet:231237
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000343 xsd:string

[Term]
id: SCDO:0000344
name: Delta Thalassemia
def: "A hereditary disorder characterized by reduced or absent delta-globin thus effecting the level of hemoglobin A2, a minor component of adult hemoglobin monitored in the diagnosis of beta-thalassemia." []
synonym: "Delta Thalassaemia" EXACT []
synonym: "Delta Thalassaemias" EXACT []
synonym: "Delta Thalassemias" EXACT []
synonym: "Delta-Thalassaemia" EXACT []
synonym: "Delta-Thalassaemias" EXACT []
synonym: "Delta-Thalassemia" EXACT []
xref: MESH:D055538
is_a: NCIT:C35069 ! Thalassemia
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055538 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000344 xsd:string

[Term]
id: SCDO:0000346
name: Dengue Fever
def: "An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with Dengue Virus. It is self-limiting and characterized by fever, myalgia, headache, and rash. Severe Dengue is a more virulent form of dengue." []
synonym: "Break Bone Fever" EXACT []
synonym: "Break-Bone fever" EXACT []
synonym: "Breakbone Fever" EXACT []
synonym: "Dengue" EXACT []
xref: MESH:D003715
is_a: NCIT:C3439 ! Viral Infection
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003715 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000346 xsd:string

[Term]
id: SCDO:0000347
name: deprecated Dental System
def: "'The system pertaining to teeth, oral cavity, and associated structures. [Curator team: []]'" []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/dentistry xsd:string
is_obsolete: true

[Term]
id: SCDO:0000359
name: deprecated terms
def: "Terms that are no longer being used in the ontology." []

[Term]
id: SCDO:0000360
name: Depression
def: "A common mental disorder, characterized by sadness, hopelessness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration. Depression can be long-lasting or recurrent, substantially impairing an individual's ability to function at work or school or cope with daily life." []
synonym: "Depressive Symptoms" EXACT []
synonym: "Low Mood" EXACT []
xref: SIO:000824
is_a: HP:0000708 ! Behavioural Abnormality
is_a: SCDO:0000746 ! Mental Health
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:0000664 SCDO:0000940 ! treated with Psychotherapy
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://www.who.int/topics/depression/en/ xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000360 xsd:string

[Term]
id: SCDO:0000365
name: Dexterity
def: "Skill in performing tasks, especially with the hands." []
is_a: SCDO:0000900 ! Physical Functioning
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://en.oxforddictionaries.com/definition/dexterity xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000376
name: Diagnostic Device
def: "A medical device used to diagnose medical conditions." []
xref: ERO:0001448
is_a: SCDO:0000379 ! Diagnostics
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0001448 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000376 xsd:string

[Term]
id: SCDO:0000379
name: Diagnostics
def: "Diagnostic tools (including the instruments, laboratory assays and methods of patient examination) used for differential diagnosis, the measurements obtained using these tools, and the diagnostic devices used in obtaining the measurements." []
is_a: SCDO:0001000 ! SCDO
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000380
name: Diclofenac
def: "A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt." []
synonym: "2-((2,6-dichlorophenyl)amino)benzeneacetic acid" EXACT []
synonym: "[2-(2,6-dichloroanilino)phenyl]acetic acid" EXACT []
synonym: "Diclofenac Acid" EXACT []
synonym: "Orthofen" EXACT []
xref: MESH:D004008
is_a: CHEBI:35475 ! Non-Steroidal Anti-Inflammatory Drug
is_a: CHEBI:35493 ! Antipyretic
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004008
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000380 xsd:string

[Term]
id: SCDO:0000382
name: Diet, Food, and Nutrition
def: "Concepts involved with nutritional physiology, including categories of substances eaten for sustenance, nutritional phenomena and processes, eating patterns and habits, and measurable nutritional parameters." []
xref: MESH:D000066888
is_a: SCDO:0000487 ! Health Behaviour
relationship: SCDO:1000018 HP:0000938 ! treats Osteopenia
relationship: SCDO:1000018 HP:0001298 ! treats Encephalopathy
relationship: SCDO:1000018 HP:0002076 ! treats Migraine
relationship: SCDO:1000018 HP:0009830 ! treats Peripheral Neuropathy
property_value: SCDO:0000303 "Should this term rather be replaced by more specific terms such as Dietary Intake? Or have such terms as sub-classes?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000066888 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000382 xsd:string

[Term]
id: SCDO:0000383
name: obsolete Diffusion Capacity by Biochemical Methods
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true

[Term]
id: SCDO:0000384
name: Diffusion Capacity of Lung
def: "The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the blood-air barrier." []
synonym: "Alveolar membrane diffusion capacity" EXACT []
synonym: "Diffusing Capacity" EXACT []
synonym: "DL" EXACT []
synonym: "Membrane diffusion capacity" EXACT []
synonym: "Pulmonary Diffusing Capacity" EXACT []
xref: MESH:D011653
is_a: CMO:0000094 ! Respiratory System Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000149 ! has essential measure Body Height
relationship: SCDO:0001297 SCDO:0000152 ! has essential measure Body Weight
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000385 ! obtained via diagnostic tool Diffusion Capacity Test
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011653 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000384 xsd:string

[Term]
id: SCDO:0000385
name: Diffusion Capacity Test
def: "Clinical assessment to determine the capacity of an individual's lung to exchange gases (e.g., oxygen and carbon dioxide) across the alveolar-capillary interface." []
synonym: "Pulmonary Diffusing Capacity Test" EXACT []
xref: phenX:810301
is_a: SCDO:0000942 ! Pulmonary Function Test
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000149 ! has essential measure Body Height
relationship: SCDO:0001297 SCDO:0000152 ! has essential measure Body Weight
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000194 SCDO:0000384 ! measures Diffusion Capacity of Lung
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Lung Function - Diffusion Capacity\")\n\nNeed to add equipment used for this test under \"Devices\" and link to them below." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810301
property_value: SCDO:0000479 "PhenX protocol: Lung Function - Diffusion Capacity #810301" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000386
name: Disability-Adjusted Life Year (DALY)
def: "One DALY can be thought of as one lost year of \"healthy\" life. The sum of these DALYs across the population, or the burden of disease, can be thought of as a measurement of the gap between current health status and an ideal health situation where the entire population lives to an advanced age, free of disease and disability." []
comment: Calculation: DALY = YLL + YLD - The YLL basically correspond to the number of deaths multiplied by the standard life expectancy at the age at which death occurs. The basic formula for YLL (without yet including other social preferences discussed below), is the following for a given cause, age and sex: YLL = N x L where: N = number of deaths L = standard life expectancy at age of death in years. Because YLL measure the incident stream of lost years of life due to deaths, an incidence perspective has also been taken for the calculation of YLD in the original Global Burden of Disease Study for year 1990 and in subsequent WHO updates for years 2000 to 2004. To estimate YLD for a particular cause in a particular time period, the number of incident cases in that period is multiplied by the average duration of the disease and a weight factor that reflects the severity of the disease on a scale from 0 (perfect health) to 1 (dead). The basic formula for YLD is the following (again, without applying social preferences): YLD = I x DW x L where: I = number of incident cases; DW = disability weight; L = average duration of the case until remission or death (years). Prevalence YLD - The recent GBD 2010 study published by IHME in December 2012 used an updated life expectancy standard for the calculation of YLL and based the YLD calculation on prevalence rather than incidence: YLD = P x DW where: P = number of prevalent cases; DW = disability weight.
synonym: "DALY" EXACT []
synonym: "Disability-Adjusted Life Year" EXACT []
is_a: SCDO:0000495 ! Health Utility
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: SCDO:0000340 https://www.who.int/healthinfo/global_burden_disease/metrics_daly/en/
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self; Proxy" xsd:string
property_value: SCDO:0000482 "All" xsd:string
property_value: SCDO:0001033 "WHO Global Burden of Disease assessment, also used in SCD studies" xsd:string
property_value: SCDO:0001222 "Children and adults" xsd:string
property_value: SCDO:0001335 "no" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000388
name: Disaster
def: "Sudden calamitous events producing great material damage, loss, and distress. They are the result of natural phenomena such as earthquakes, floods, etc. Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community." []
synonym: "Disasters" EXACT []
synonym: "Natural Disaster" EXACT []
synonym: "Natural Disasters" EXACT []
xref: MESH:D004190
is_a: SCDO:0000897 ! Physical Environment
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004190 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000388 xsd:string

[Term]
id: SCDO:0000391
name: Disease Modifier
def: "A factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease." []
synonym: "Phenotypic Modifier" EXACT []
is_a: SCDO:0001000 ! SCDO
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000303 "These article contains a recent description of disease modifiers for SCD: http://www.nejm.org/doi/10.1056/NEJMra1510865 -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562292/ --  -- Paper mentioning haplotypes and severity: -- https://www.nature.com/scitable/topicpage/sickle-cell-anemia-a-look-at-global-8756219 --  -- Initially, the HP term \"Clinical Modifier\" (HP:0012823) was used to define this class, but its usage was found to be more \"ontology-based\" than what the SCDO intended." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000396
name: Doppler Ultrasound Machine - 2 Megahertz
def: "A diagnostic ultrasound-based imaging technique operating at the frequency range of 2 megahertz. This machine makes use of the doppler effect to measure and visualise blood flow for possible pathology or lesions within blood vessels." []
is_a: OBI:0001098 ! Ultrasound Machine
relationship: SCDO:1000191 SCDO:0001114 ! used by diagnostic tool Stroke Risk Test in Children with Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000397
name: Drug Clearance Decreased AE
def: "An adverse event that has an outcome of a decreased amount of the drug excreted by the body." []
xref: OAE:0000887
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000887 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000397 xsd:string

[Term]
id: SCDO:0000398
name: Drug Dependence AE
def: "An adverse drug event that results in the development of a dependence on the drug." []
xref: OAE:0000888
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000888 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000398 xsd:string

[Term]
id: SCDO:0000399
name: Drug Intake
def: "The amount of drug substances taken into the body." []
is_a: SCDO:0000487 ! Health Behaviour
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "This seemed an obvious addition to the modifier class?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000400
name: Drug Intolerance AE
def: "A drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug." []
xref: OAE:0000891
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000891 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000400 xsd:string

[Term]
id: SCDO:0000401
name: Drug Withdrawal Syndrome AE
def: "An adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug." []
xref: OAE:0000893
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000893 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000401 xsd:string

[Term]
id: SCDO:0000402
name: Drug-Induced Neuropathy AE
def: "A neuropathy AE that is induced by a drug administration." []
xref: OAE:0000165
is_a: SCDO:0000191 ! Causal Adverse Drug Event
relationship: SCDO:1000199 CHEBI:23888 ! induced by Drug
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0000165 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000402 xsd:string

[Term]
id: SCDO:0000405
name: deprecated Ear, Nose and Throat
def: "'The combined specialties of diseases of the ear, pharynx, and larynx, including the upper respiratory tract and diseases of the head and neck, tracheobronchial tree, and esophagus. [Curator team: []]'" []
synonym: "Otolaryngology" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/ear+nose+and+throat xsd:string
is_obsolete: true

[Term]
id: SCDO:0000407
name: Ecchymosis
def: "A small hemorrhagic spot, larger than a petechia, in the skin or mucous membrane forming a nonelevated, rounded or irregular, blue or purplish patch." []
synonym: "Ecchymoses" EXACT []
xref: HP:0031364
is_a: HP:0002597 ! Abnormality of the Vasculature
property_value: SCDO:0000303 "Suggest update to description. The term in the HPO was not detailed enough." xsd:string
property_value: SCDO:0000340 "v=onepage&q&f=false"
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000409
name: Echocardiogram
def: "A physiological assay that uses standard ultrasound techniques to take two-dimensional pictures of the cardiovascular system and can produce accurate assessment of the velocity of blood and cardiac tissue at any arbitrary point using pulsed or continuous wave Doppler ultrasound." []
synonym: "Cardiac ECHO" EXACT []
synonym: "Cardiac US Scan" EXACT []
synonym: "Diagnostic Ultrasound of Heart" EXACT []
synonym: "Echocardiographic procedure" EXACT []
synonym: "Echocardiography" EXACT []
synonym: "Ultrasonic cardiography" EXACT []
synonym: "Ultrasonography of Heart" EXACT []
synonym: "Ultrasound of Heart" EXACT []
synonym: "US Scan of Heart" EXACT []
xref: ERO:0000385
is_a: NCIT:C17230 ! Ultrasound Test
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0000385 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000409 xsd:string

[Term]
id: SCDO:0000410
name: Echocardiography Machine
def: "A machine used for ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues." []
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:0000474 SCDO:0000502 ! has output measurement Heart Valve Measurement
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004452 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000414
name: Education
def: "Acquisition of knowledge as a result of instruction in a formal course of study." []
synonym: "Schooling" EXACT []
xref: MESH:D004493
is_a: NCIT:C17047 ! Quality of Life
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004493 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000414 xsd:string

[Term]
id: SCDO:0000415
name: Electrocardiogram
def: "The visual output that an electrocardiograph produces." []
synonym: "ECG" EXACT []
synonym: "EKG" EXACT []
xref: ERO:0000383
is_a: SCDO:1000313 ! Diagnostic Device Visual Output
property_value: SCDO:0000303 "Suggest update to description in ERO?" xsd:string
property_value: SCDO:0000340 http://en.wiktionary.org/wiki/electrocardiogram xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000416
name: Electrocardiographic Monitor
def: "Device which makes prolonged electrocardiographic recordings on a portable tape recorder (Holter-type system) or solid-state device (real-time system), while the patient undergoes normal daily activities; useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia." []
synonym: "Ambulatory Electrocardiographic Monitor" EXACT []
synonym: "Electrocardiocorder" EXACT []
xref: CRISP:1393-7164
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 NCIT:C123446 ! used by diagnostic tool Continuous Ambulatory ECG
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/CRISP/?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FCSP%2F1393-7164 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000416 xsd:string

[Term]
id: SCDO:0000417
name: Electrocardiography
def: "Recording of the moment-to-moment electromotive forces of the heart as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a cathode ray tube display." []
xref: MESH:D004562
is_a: SCDO:0000500 ! Heart Function Test
relationship: SCDO:1000192 SCDO:0000183 ! uses diagnostic device Cardioscope
relationship: SCDO:1000192 SCDO:0001295 ! uses diagnostic device Electrocardiograph
property_value: SCDO:0000303 "Request that MESH removes ECG, EKG and Elecrocardiogram as synonyms." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004562
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000417 xsd:string

[Term]
id: SCDO:0000418
name: Electroencephalogram
def: "A graphic record of the electrical activity of the brain as recorded by an electroencephalograph." []
is_a: SCDO:1000313 ! Diagnostic Device Visual Output
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/electroencephalogram xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000419
name: Electroencephalograph
def: "An instrument that measures electrical potentials on the scalp and generates a record of the electrical activity of the brain." []
synonym: "Encephalograph" EXACT []
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 SCDO:0000420 ! used by diagnostic tool Electroencephalography
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/electroencephalograph xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000420
name: Electroencephalography
def: "Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain." []
synonym: "EEG" EXACT []
xref: MESH:D004569
is_a: SCDO:0000208 ! Cerebral Function Assay
relationship: SCDO:1000192 SCDO:0000419 ! uses diagnostic device Electroencephalograph
relationship: SCDO:1000194 SCDO:0000161 ! measures Brain Electrical Activity
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004569 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000420 xsd:string

[Term]
id: SCDO:0000423
name: Electronic Health Records
def: "Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient." []
synonym: "Computerized Health Records" EXACT []
synonym: "Computerized Medical Records" EXACT []
synonym: "Electronic Health Record" EXACT []
synonym: "Electronic Medical Record" EXACT []
synonym: "Electronic Medical Records" EXACT []
xref: MESH:D057286
is_a: SCDO:0000492 ! Health Records
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D057286 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000423 xsd:string

[Term]
id: SCDO:0000424
name: Electrophoresis
def: "An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current." []
xref: MESH:D004586
is_a: SCDO:0000216 ! Chemical Assay
property_value: http://purl.org/dc/elements/1.1/source http://labtestsonline.org/understanding/analytes/hemoglobin-var/tab/test/
property_value: SCDO:0000303 "Perhaps change label to \"Hemoglobin Electrophoresis\"? Exactsynonym \"Hb ELP\". See dc:source provided." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004586 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000424 xsd:string

[Term]
id: SCDO:0000431
name: deprecated Endocrine and Metabolic
def: "The system pertaining to the stomach, intestines, and associated organs including liver, gallbladder, and pancreas." []
synonym: "Gastroenterology" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/gastroenterology xsd:string
is_obsolete: true
replaced_by: SCDO:0002674
replaced_by: SCDO:0002780

[Term]
id: SCDO:0000435
name: Environmental Disease Modifier
def: "An environmental factor that modifies one or more aspects of sickle cell disease (SCD) (such as temporal pattern, age of onset and mortality) for specific phenotype(s) in the Phenotype class." []
is_a: SCDO:0000391 ! Disease Modifier
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nPerhaps include MESH term \"Life Change Events\" as a main sub-class, with \"Disaster\" (under Physical Environment) copied below it?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000436
name: Enzymatic Assay
def: "A method used to measure the relative activity of a specific enzyme or its concentration in solution. Typically an enzyme substrate is added to a buffer solution containing enzyme and the rate of conversion of substrate to product is measured under controlled conditions. Many classical enzymatic assay methods involve the use of synthetic colorimetric substrates and measuring the reaction rates using a spectrophotometer." []
synonym: "Enzyme Assay" EXACT []
xref: MESH:D057075
is_a: SCDO:0000120 ! Biochemical Assay
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D057075 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000436 xsd:string

[Term]
id: SCDO:0000437
name: Epidemiologic Studies
def: "Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are case-control studies; cohort studies; and cross-sectional studies." []
synonym: "Epidemiological Studies" EXACT []
xref: MESH:D016021
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000303 "Term to be adapted as necessary to match EDDA Study Designs Taxonomy" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016021 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000437 xsd:string

[Term]
id: SCDO:0000438
name: deprecated Epidemiologic Study Characteristics as Topic
def: "Types and formulations of studies used in epidemiological and clinical research." []
synonym: "Epidemiologic Study Characteristics" EXACT []
xref: MESH:D016020
is_a: SCDO:0000990 ! obsolete Research Activity
property_value: SCDO:0000303 "Term to be adapted as necessary to match EDDA Study Designs Taxonomy" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016020 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000440
name: Epilepsy Screener
def: "A questionnaire to assess epilepsy, a condition characterized by recurrent seizures and which is a component of over 40 neurological disorders (Aminoff, et al., 2005)." []
xref: phenX:130401
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/130401
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000440 xsd:string

[Term]
id: SCDO:0000441
name: General Health Questionnaire (GHQ)
def: "The GHQ is a screening device for identifying minor psychiatric disorders in the general population and within community or non-psychiatric clinical settings such as primary care or general medical outpatients. Suitable for all ages from adolescent upwards (not children), it assesses the respondent's current state and asks if that differs from his or her usual state. It is therefore sensitive to short-term psychiatric disorders but not to long-standing attributes of the respondent. The self-administered questionnaire focuses on two major areas: inability to carry out normal functions; appearance of new and distressing phenomena. It is available in the following versions: GHQ-60 -- the fully detailed 60-item questionnaire; GHQ-30 -- a short form without items relating to physical illness; GHQ-28 -- a 28 item scaled version -- assesses somatic symptoms, anxiety and insomnia, social dysfunction and severe depression; GHQ-12 -- quick, reliable and sensitive short form, ideal for research studies." []
synonym: "GHQ" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Add the different versions of this questionnaire, as listed in the description here." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Goldberg, David; Hillier, Valerie (1979). \"A scaled version of the General Health Questionnaire\". Psychological Medicine. Cambridge University Press. 9 (01): 139–145." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000442
name: Generalised Anxiety Disorder Questionnaire (GAD-7)
def: "The GAD-7 is a self-administered patient questionnaire used as a screening tool and severity measure for generalised anxiety disorder. The GAD-7 score is calculated by assigning scores of 0, 1, 2, and 3, to the response categories of 'not at all', 'several days', 'more than half the days', and 'nearly every day', respectively, and adding together the scores for the seven questions. Scores of 5, 10, and 15 are taken as the cut-off points for mild, moderate and severe anxiety, respectively. When used as a screening tool, further evaluation is recommended when the score is 10 or greater." []
synonym: "GAD-7" EXACT []
synonym: "Generalised Anxiety Disorder Questionnaire" EXACT []
xref: NCIT:C88893
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
property_value: SCDO:0000340 "Spitzer RL, Kroenke K, Williams JB, et al; A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine. 2006;166(10):1092-7." xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000443
name: Genetic Counseling
def: "An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered." []
synonym: "Prenatal Genetic Counseling" EXACT []
xref: MESH:D005817
is_a: SCDO:0000447 ! Genetic Service
relationship: SCDO:1000018 SCDO:0000032 ! treats Agenesis of Corpus Callosum
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005817 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000443 xsd:string

[Term]
id: SCDO:0000444
name: Genetic Disease Modifier
def: "A biological disease modifier that is of a genetic nature." []
is_a: SCDO:0000122 ! Biological Disease Modifier
relationship: SCDO:1000015 OGMS:0000047 ! modifies Genetic Disorder
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000447
name: Genetic Service
def: "Organized services to provide diagnosis, treatment, and prevention of genetic disorders." []
synonym: "Genetic Services" EXACT []
xref: MESH:D033142
is_a: SCDO:0000922 ! Preventative Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D033142 xsd:string
property_value: SCDO:1000288 "Sufficiient" xsd:string

[Term]
id: SCDO:0000448
name: Genetic Technique
def: "Chromosomal, biochemical, intracellular, and other methods used in the study of genetics." []
synonym: "Genetic Technic" EXACT []
synonym: "Genetic Technics" EXACT []
synonym: "Genetic Techniques" EXACT []
xref: MESH:D005821
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000303 "This and its sub-classes need work!" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005821 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000448 xsd:string

[Term]
id: SCDO:0000454
name: Glaucoma (Secondary to Presence of Blood in the Anterior Chamber of the Eye)
def: "Elevated ocular pressure caused by clogging of the trabecular meshwork and by impaired aqueous humor outflow from blood in the anterior chamber (due to ocular trauma or surgery)." []
synonym: "Glaucomas" EXACT []
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:0000663 NCIT:C101217 ! diagnosed using tool Retinal Examination
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: SCDO:0000303 "Request inclusion into relevant ontology as more specific type (sub-class) of glaucoma." xsd:string
property_value: SCDO:0000340 "Ballas et al 2010 Am J Hematol" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000455
name: Global Mental Status Screener
def: "A test to assess the respondent's overall mental capability." []
xref: phenX:130700
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F130700
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000455 xsd:string

[Term]
id: SCDO:0000456
name: Globin Locus
def: "A genetic locus responsible for the encoding of globins." []
is_a: SCDO:1000103 ! Genetic Locus
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps below \"Genetic Locus\" in MESH." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000457
name: Glomerular Filtration Rate
def: "Measurement of the flow rate of filtered fluid through the kidney, calculated either by comparative measurements of substances in the blood and urine, or estimated from a blood test." []
synonym: "GFR" EXACT []
xref: EFO:0005208
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_0005208 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000457 xsd:string

[Term]
id: SCDO:0000462
name: G6PD
def: "This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene." []
synonym: "G-6-PD" EXACT []
synonym: "G6PD1" EXACT []
synonym: "Glucose-6-Phosphate 1-Dehydrogenase Gene" EXACT []
synonym: "Glucose-6-Phosphate Dehydrogenase Gene" EXACT []
is_a: SCDO:0000810 ! Non-Globin Gene
property_value: SCDO:0000303 "Exists in other ontologies but we have provided a description more relevant to its relationship with SCD." xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/gene/2539 xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0000465
name: Growth Delay
def: "A deficiency or slowing down of growth pre- and postnatally greater than two standard deviations from the age- and sex-related normal." []
synonym: "Delayed Growth" EXACT []
synonym: "Growth Deficiency" EXACT []
synonym: "Growth Failure" EXACT []
synonym: "Growth Retardation" EXACT []
synonym: "Poor Growth" EXACT []
synonym: "Retarded Growth" EXACT []
xref: HP:0001510
is_a: HP:0001507 ! Growth Abnormality
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:0000664 SCDO:0000262 ! treated with Cognitive Therapy
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Suggest update to description in HPO." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001510 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000466
name: Haptoglobin Blood Test
def: "A bioassay to measure haptoglobin, which is produced by the liver and transports hemoglobin to the liver for recycling." []
xref: phenX:10801
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1000194 CMO:0002520 ! measures Serum Haptoglobin Level
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Haptoglobin Level\")." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810801
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000487
name: Health Behaviour
def: "Individual lifestyle and behavior which may or may not enhance or maintain good health." []
synonym: "Health Behavior" EXACT []
xref: APAONTO:Health_Behavior
is_a: SCDO:0000435 ! Environmental Disease Modifier
property_value: SCDO:0000303 "Suggest the NCIT updates their description for this term to include negative /risk inreasing behaviour?\n\nInclude: \n-- gaining better control of your diabetes \n-- lowering cholesterol\n-- lowering blood pressure \n-- maintaining a healthy body weight \n-- eating a balanced diet \n\n-- Include these from MESH: \n-- Treatment Refusal \n-- Vaccination Refusal" xsd:string
property_value: SCDO:0000340 APAONTO?p=classes&conceptid=http%3A%2F%2Fontology.apa.org%2Fapaonto%2FtermsonlyOUT%2520(5).owl%23Health:Behavior
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000487 xsd:string

[Term]
id: SCDO:0000488
name: Health Beliefs
def: "People's beliefs about health problems, perceived benefits of action and barriers to action, and self-efficacy." []
comment: The health belief model suggests that health beliefs explain engagement (or lack of engagement) in health-promoting behaviour.
is_a: SCDO:0000299 ! Culture
property_value: http://purl.org/dc/elements/1.1/source "Health-Belief Model" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://en.wikipedia.org/wiki/Health_belief_model
property_value: SCDO:0000340 https://en.wikipedia.org/wiki/Health_belief_model
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0000489
name: Health Financing
def: "Health financing is concerned with how financial resources are generated, allocated and used in health systems. Health financing policy focuses on how to move closer to universal coverage with issues related to: (i) how and from where to raise sufficient funds for health; (ii) how to overcome financial barriers that exclude many poor from accessing health services; or (iii) how to provide an equitable and efficient mix of health services." []
synonym: "Health Care Resources" EXACT []
synonym: "Healthcare Resources" EXACT []
is_a: SCDO:0000494 ! Health System
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://multimedia.wpro.who.int/galleries/189/health-financing/35
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000490
name: Health Insurance Coverage
def: "Whether the respondent is covered by health insurance or some other form of health care coverage at the time of the interview." []
comment: Also applicable to a population not just to an individual.
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0000496 ! Healthcare Access
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest inclusion into MESH.\n\nThe phenX term is actually referring to a protocol for collecting data on Health Insurance Coverage.\n\nThe protocol is somewhat U.S. specific. Should probably be modified to be more relevant to the African setting." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/11502
property_value: SCDO:0000479 "PhenX protocol: Health Insurance Coverage #11502" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000491
name: Health Literacy
def: "Degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions." []
synonym: "Genetic Counseling" NARROW []
synonym: "Knowledge about Sickle Cell Disease" EXACT []
xref: MESH:D057220
is_a: SCDO:0000286 ! Coping Skill
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D057220 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000491 xsd:string

[Term]
id: SCDO:0000492
name: Health Records
def: "Health data accessible to the patient and others." []
synonym: "Health Records, Personal" EXACT []
synonym: "Personal Health Information" EXACT []
synonym: "Personal Health Record" EXACT []
synonym: "Personal Health Records" EXACT []
synonym: "Personal Medical Record" EXACT []
synonym: "Personal Medical Records" EXACT []
xref: MESH:D055991
is_a: SCDO:0000738 ! Medical Records
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055991 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000492 xsd:string

[Term]
id: SCDO:0000493
name: Health Service Utilization
def: "The measure of the population's use of the health care services available to them. This includes the utilization of hospital resources, Personal Care Home (PCH) resources, and physician resources. Health care utilization and health status are used to examine how efficiently a health care system produces health in a population." []
synonym: "Health Care Service Utilization" EXACT []
synonym: "Health Care Utitlization" EXACT []
synonym: "Healthcare Utitlization" EXACT []
is_a: SCDO:0000948 ! Quality of Health Care
property_value: http://purl.org/dc/elements/1.1/source http://mchp-appserv.cpe.umanitoba.ca/viewDefinition.php?definitionID=102752
property_value: SCDO:0000340 http://mchp-appserv.cpe.umanitoba.ca/viewDefinition.php?definitionID=102752
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000494
name: Health System
def: "A system responsible for delivering services that improve, maintain or restore the health of individuals and their communities. This includes the care provided by hospitals and family doctors, but also less visible tasks such as the prevention and control of communicable disease, health promotion, health workforce planning and improving the social, economic or environmental conditions in which people live." []
synonym: "Health Care Delivery" EXACT []
synonym: "Health Care System" EXACT []
synonym: "Health Care Systems" EXACT []
is_a: SCDO:0000948 ! Quality of Health Care
property_value: SCDO:0000303 "Suggest update to description in Medline Plus Health Topics" xsd:string
property_value: SCDO:0000340 http://www.euro.who.int/en/health-topics/Health-systems/pages/health-systems xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000495
name: Health Utility
def: "Utility measures of health related quality of life are preference values that patients attach to their overall health status. In clinical trials, utility measures summarize both positive and negative effects of an intervention into one value between 0 (equal to death) and 1 (equal to perfect health). These measures allow for comparison of patient outcomes of different diseases, and for comparison between various health care interventions. There are 2 different approaches to utility measurement." []
synonym: "Health Utility Index" EXACT []
synonym: "Health Utility Measure" EXACT []
is_a: SCDO:0000948 ! Quality of Health Care
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/pubmed/7674256 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000496
name: Healthcare Access
def: "The ease with which an individual can obtain needed medical services." []
comment: The WHO Constitution envisages "...the highest attainable standard of health as a fundamental right of every human being." The right to health includes access to timely, acceptable, and affordable health care of appropriate quality.
synonym: "Access to Healthcare" EXACT []
synonym: "Health Care Access" EXACT []
is_a: SCDO:0000948 ! Quality of Health Care
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.rand.org/topics/health-care-access.html
property_value: http://purl.org/dc/elements/1.1/source http://www.who.int/mediacentre/factsheets/fs323/en/
property_value: SCDO:0000303 "Additional WG note:\norganization of health system [insurance]; electronic (portable) health records; special issues related to pain and pain medications; levels of care (primary, secondary, tertiary) (Location – [rural/urban; mobile units]; hours; affordability; timeliness). Availability of personnel. Equipment treatments other resources" xsd:string
property_value: SCDO:0000340 https://www.rand.org/topics/health-care-access.html
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000497
name: Healthy Diet
def: "Dietary patterns which have been found to be important in reducing disease risk." []
synonym: "Healthy Eating" EXACT []
xref: MESH:D000072001
is_a: NCIT:C15900 ! Lifestyle Therapy
is_a: SCDO:0000487 ! Health Behaviour
relationship: SCDO:1000018 HP:0000819 ! treats Diabetes Mellitus
relationship: SCDO:1000018 HP:0000855 ! treats Insulin Resistance
relationship: SCDO:1000018 HP:0000938 ! treats Osteopenia
relationship: SCDO:1000018 HP:0001513 ! treats Obesity
relationship: SCDO:1000018 HP:0002076 ! treats Migraine
relationship: SCDO:1000018 HP:0002138 ! treats Subarachnoid Hemorrhage
relationship: SCDO:1000018 HP:0003611 ! treats Dyslipidemia
relationship: SCDO:1000018 SCDO:0001168 ! treats Transient Monocular Blindness
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000072001 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000497 xsd:string

[Term]
id: SCDO:0000498
name: Healthy Lifestyle
def: "A pattern of behavior involving lifestyle choices which ensure optimum health. Examples are eating right; maintaining physical, emotional, and spiritual wellness, and taking preemptive steps against communicable diseases." []
synonym: "Healthy Life Style" EXACT []
xref: MESH:D000070497
is_a: SCDO:0000689 ! Lifestyle
relationship: SCDO:1000018 HP:0000855 ! treats Insulin Resistance
relationship: SCDO:1000018 HP:0000938 ! treats Osteopenia
relationship: SCDO:1000018 HP:0002870 ! treats Obstructive Sleep Apnea
relationship: SCDO:1000018 HP:0003611 ! treats Dyslipidemia
relationship: SCDO:1000018 SCDO:0001168 ! treats Transient Monocular Blindness
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000070497 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000498 xsd:string

[Term]
id: SCDO:0000500
name: Heart Function Test
def: "Examinations used to diagnose and treat heart conditions." []
synonym: "Heart Function Tests" EXACT []
synonym: "Pulmonary Function Test" EXACT []
xref: MESH:D006334
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006334 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000500 xsd:string

[Term]
id: SCDO:0000501
name: Heart Rate
def: "The number of times the heart ventricles contract per unit of time, usually per minute." []
synonym: "Heart Beat" EXACT []
synonym: "Pulse" EXACT []
synonym: "Pulse Rate" EXACT []
xref: EFO:0004326
is_a: SCDO:1000317 ! Heart Measurement
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_0004326 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000501 xsd:string

[Term]
id: SCDO:0000502
name: Heart Valve Measurement
def: "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart valves." []
is_a: SCDO:1000317 ! Heart Measurement
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000409 ! obtained via diagnostic tool Echocardiogram
relationship: SCDO:1000193 SCDO:0000410 ! output of diagnostic device Echocardiography Machine
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Perhaps below \"Heart Measurement\" in the CMO. \n\nCan add sub-classes as per the measurements given in the Diagnostic Criteria below the Protocol section in PhenX for \"Heart Valve Function\".\n\nSub-classes that are also morphological measurements can be included below \"Body Morphological Measurement\"" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000504
name: Hematology Analyzer
def: "A measurement device used to perform complete blood counts, erythrocyte sedimentation rates (ESRs), or coagulation tests." []
synonym: "Haematology Analyser" EXACT []
xref: ERO:0000494
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:0000474 CMO:0000025 ! has output measurement Red Blood Cell Count
relationship: SCDO:0000474 CMO:0000027 ! has output measurement White Blood Cell Count
relationship: SCDO:0000474 CMO:0000029 ! has output measurement Platelet Count
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0000494 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000504 xsd:string

[Term]
id: SCDO:0000505
name: Hematology Screening Test
def: "A test to detect potential blood disorders or diseases in people who do not have any symptoms of disease." []
synonym: "Haematology Screening Test" EXACT []
is_a: SCDO:0000133 ! Blood Test
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 https://www.hopkinsmedicine.org/healthlibrary/conditions/pathology/screening_tests_for_common_diseases_85,P00965
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000506
name: Hematopoietic Stem Cell Transplantation
def: "Transfer of hematopoietic stem cells from bone marrow or blood between individuals within the same species (transplantation, homologous) or transfer within the same individual (transplantation, autologous). Hematopoietic stem cell transplantation has been used as an alternative to bone marrow transplantation in the treatment of a variety of neoplasms." []
synonym: "BMT" EXACT []
synonym: "Bone Marrow Transplant" EXACT []
synonym: "Hematopoietic SCT" EXACT []
xref: MESH:D018380
is_a: SCDO:0000301 ! Curative Therapeutics
relationship: SCDO:1000018 DOID:1584 ! treats Acute Chest Syndrome
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 HP:0002665 ! treats Lymphoma
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1000018 NCIT:C98835 ! treats Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000018 SCDO:0000518 ! treats Hemoglobin Barts Hydrops Fetalis
relationship: SCDO:1000018 SCDO:0000519 ! treats Hemoglobin C Disease
relationship: SCDO:1000018 SCDO:1000077 ! treats Moderate Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1000018 SCDO:1000078 ! treats Severe Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018380 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000506 xsd:string

[Term]
id: SCDO:0000507
name: deprecated Hematopoietic System
def: "The blood-making organs and tissues, principally the bone marrow and lymph nodes." []
xref: MESH:D006413
is_a: SCDO:0000511 ! obsolete Hemic and Immune Systems
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006413 xsd:string
is_obsolete: true
replaced_by: SCDO:1000264

[Term]
id: SCDO:0000508
name: Hematuria
def: "Presence of blood in the urine." []
synonym: "Blood in Urine" EXACT []
synonym: "Hematurias" EXACT []
xref: MESH:D006417
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006417 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000508 xsd:string

[Term]
id: SCDO:0000510
name: HMOX1
def: "This gene encodes the enzyme, heme oxygenase 1, an essential enzyme in heme catabolism and cellular homeostasis." []
synonym: "Heat Shock Protein, 32-kD Gene" EXACT []
synonym: "Heme Oxygenase (Decycling) 1 Gene" EXACT []
synonym: "Heme Oxygenase 1 gene" EXACT []
synonym: "Hemeoxygenase 1 Gene" EXACT []
synonym: "Hemoxygenase-1 Gene" EXACT []
synonym: "HMOX1 Gene" EXACT []
synonym: "HO-1" EXACT []
synonym: "HO1 Gene" EXACT []
is_a: SCDO:0000810 ! Non-Globin Gene
property_value: SCDO:0000303 "Suggest update to description in NCIT (for \"HMOX1 Gene\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C43314
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/gene/3162 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000511
name: obsolete Hemic and Immune Systems
def: "Organs involved in the production of BLOOD, including the cellular and the molecular components essential in providing defense against foreign organisms or substances." []
is_a: SCDO:0001336 ! from phenotype
is_obsolete: true

[Term]
id: SCDO:0000513
name: Hemoglobin C
def: "A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes." []
synonym: "Hb C" EXACT []
synonym: "HbC" EXACT []
synonym: "HbC Hemoglobin" EXACT []
xref: MESH:D006444
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:1000041 ! has causal or contributing genetic variation HBB, GLU6LYS
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006444 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000513 xsd:string

[Term]
id: SCDO:0000514
name: Hemoglobin S
def: "An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia." []
synonym: "Haemoglobin S" EXACT []
synonym: "Hb S" EXACT []
synonym: "HbS" EXACT []
synonym: "HbS Haemoglobin" EXACT []
synonym: "HbS Hemoglobin" EXACT []
synonym: "Sickle Haemoglobin" EXACT []
synonym: "Sickle Hemoglobin" EXACT []
xref: MESH:D006451
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006451 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000514 xsd:string

[Term]
id: SCDO:0000515
name: Hemoglobin H
def: "An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in alpha-thalassemia." []
synonym: "Hb H" EXACT []
synonym: "HbH" EXACT []
synonym: "HbH Hemoglobin" EXACT []
xref: MESH:D006447
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:0001386 ! has causal or contributing genetic variation Alpha-Globin Locus Deletion
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006447 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000515 xsd:string

[Term]
id: SCDO:0000516
name: deprecated Hemoglobin A2 Profile
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:1000288 "None" xsd:string
is_obsolete: true
replaced_by: SCDO:1000698

[Term]
id: SCDO:0000517
name: Hemoglobin Barts
def: "An abnormal hemoglobin, composed of four gamma globin chains, causing it to have an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues." []
synonym: "Haemoglobin Bart's" EXACT []
synonym: "Haemoglobin Barts" EXACT []
synonym: "Hb Bart's" EXACT []
synonym: "Hb Barts" EXACT []
synonym: "Hemoglobin Bart's" EXACT []
xref: HP:0005507
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:0001387 ! has causal or contributing genetic variation Homozygous Deletion of HBA1 and HBA2
property_value: SCDO:0000303 "Additional info from the definition in HPO: \"Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues.\"" xsd:string
property_value: SCDO:0000303 "Suggest update to description in HP as we have done." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0005507 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000518
name: Hemoglobin Barts Hydrops Fetalis
def: "The most severe form of alpha-thalassemia and is almost always lethal, and characterized by fetal onset of generalized edema, pleural and pericardial effusions, and severe hypochromic anemia. It is caused by the presence of Hemoglobin Barts, a hemoglobin with four gamma chains, which has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues" []
synonym: "Alpha-Thalassemia Hydrops Fetalis" EXACT []
synonym: "Alpha-Thalassemia Major" EXACT []
synonym: "Haemoglobin Barts Hydrops Fetalis" EXACT []
synonym: "Hb Barts" EXACT []
synonym: "Hb Barts Syndrome" EXACT []
synonym: "Hemoglobin Bart's Hydrops Fetalis" EXACT []
synonym: "Hemoglobin Barts Hydrops Fetalis Syndrome" EXACT []
synonym: "Homozygous Alpha 0-Thalassemia" EXACT []
xref: Orphanet:163596
is_a: SCDO:0000042 ! Alpha Thalassemia
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:0000663 SCDO:0003894 ! diagnosed using tool Gap PCR
relationship: SCDO:0000663 SCDO:0006589 ! diagnosed using tool Cordocentesis
relationship: SCDO:0000664 NCIT:C15238 ! treated with Gene Therapy
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:0000664 SCDO:0008888 ! treated with Iron Chelation Therapy
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:0001387 ! has causal genotype Homozygous Deletion of HBA1 and HBA2
relationship: SCDO:1000210 SCDO:0001387 ! has causal or contributing genetic variation Homozygous Deletion of HBA1 and HBA2
relationship: SCDO:1000223 SCDO:1000241 ! has causal molecular phenotype Absent Hemoglobin A
property_value: SCDO:0000303 "Suggest update to description in ORDO as we have done." xsd:string
property_value: SCDO:0000340 http://www.orpha.net/ORDO/Orphanet_163596 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000519
name: Hemoglobin C Disease
def: "An autosomal recessive disorder resulting from the production of hemoglobin C, secondary to an amino acid substitution of lysine for glutamic acid in the sixth position of the beta chain (E6K), and characterized by mild hemolytic anemia and occasionally jaundice, though most patients are asymptomatic." []
synonym: "Haemoglobin C Disease" EXACT []
synonym: "Hb C-Disease" EXACT []
xref: NCIT:C34675
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
relationship: SCDO:0000663 CHMO:0001009 ! diagnosed using tool High-Performance Liquid Chromatography
relationship: SCDO:0000663 CMO:0000364 ! diagnosed using tool Complete Blood Count
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:0000664 SCDO:0001329 ! treated with Folic Acid
relationship: SCDO:0001364 SCDO:1000242 ! has mode of inheritance Autosomal Recessive Homozygous
relationship: SCDO:1000172 SCDO:1000232 ! has causal genotype Hemoglobin Genotype CC
relationship: SCDO:1000210 SCDO:1000041 ! has causal or contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000218 HP:0001878 ! has manifestation Hemolytic Anemia
relationship: SCDO:1000223 SCDO:0000513 ! has causal molecular phenotype Hemoglobin C
property_value: SCDO:0000303 "Suggest update to description in NCIT" xsd:string
property_value: SCDO:0000340 http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-C xsd:string
property_value: SCDO:0000340 NCIT:C34675
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000520
name: Hemoglobin C Trait
def: "The inheritance of the gene for hemoglobin C from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." []
synonym: "Haemoglobin C-A Disorder" EXACT []
synonym: "Hb AC" EXACT []
synonym: "Hemoglobin C-A Disorder" EXACT []
synonym: "Heterozygous for Hb C" EXACT []
is_a: NCIT:C95534 ! Hemoglobin Trait
relationship: SCDO:1000172 SCDO:1000225 ! has causal genotype Hemoglobin Genotype AC
relationship: SCDO:1000210 SCDO:1000041 ! has causal or contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000218 NCIT:C3833 ! has manifestation Asymptomatic
property_value: http://purl.org/dc/elements/1.1/source http://www.sickle-thal.nwlh.nhs.uk/blood/haemoglobinc.aspx
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." xsd:string
property_value: SCDO:0000340 http://www.sickle-thal.nwlh.nhs.uk/blood/haemoglobinc.aspx xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000521
name: deprecated Hemoglobin C-Beta Thalassemia
def: "'A form of beta-thalassemia with a phenotype of mild to moderate hemolytic anemia. Patients are often asymptomatic but if present symptoms include anemia and enlarged spleen.'" []
synonym: "Hb C-Beta Thalassemia Syndrome" EXACT []
synonym: "Hemoglobin C Beta-Thalassemia" EXACT []
is_a: SCDO:0000272 ! obsolete Compound Heterozygous Hemoglobinopathy
property_value: SCDO:0000303 "The description could be more detailed." xsd:string
property_value: SCDO:0000340 http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=231242 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000522
name: Hemoglobin Variant Test
def: "A test to measure the presence and amount of a variant of hemoglobin in the blood." []
synonym: "Haemoglobin Variant Observation" EXACT []
synonym: "Haemoglobin Variant Test" EXACT []
synonym: "Haemoglobinopathy Screen" EXACT []
synonym: "Hemoglobin Variant Measurement" EXACT []
synonym: "Hemoglobin Variant Observation" EXACT []
synonym: "Hemoglobinopathy Screen" EXACT []
xref: NCIT:C103845
is_a: SCDO:0000133 ! Blood Test
property_value: SCDO:0000303 "Many terms below \"Hemoglobin Variant Test\" in SNOMED CT could be added." xsd:string
property_value: SCDO:0000303 "Suggest update to label and description in NCIT (from \"Hemoglobin Variant Measurement\" and \"A test to measure the variants of hemoglobin.\")\nIt is not clear whether this term was is in fact a synonym of \"Hemoglobin Profile Assay\". We assumed it wasn't. If it actually is, we need to address the ambiguity caused." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C103845 xsd:string
property_value: SCDO:1000288 "Suggest update to label and description" xsd:string

[Term]
id: SCDO:0000524
name: Hemoglobin D Disease
def: "An autosomal recessive hemoglobinopathy characterized by production of abnormal variant hemoglobin known as hemoglobin D, with no or mild clinical manifestations (splenomegaly, very mild anemia)." []
synonym: "Hb DD" EXACT []
synonym: "Homozygous Hemoglobin D" EXACT []
xref: DOID:5378
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:1000230 ! has causal genotype Hemoglobin Genotype DD
relationship: SCDO:1000210 SCDO:1000108 ! has causal or contributing genetic variation HBB, SER9TYR
relationship: SCDO:1000210 SCDO:1000109 ! has causal or contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000210 SCDO:1000110 ! has causal or contributing genetic variation HBB, GLY16ARG
relationship: SCDO:1000210 SCDO:1000111 ! has causal or contributing genetic variation HBB, ASN19LYS
relationship: SCDO:1000210 SCDO:1000112 ! has causal or contributing genetic variation HBB, GLU22GLN
relationship: SCDO:1000210 SCDO:1000113 ! has causal or contributing genetic variation HBB, GLU22VAL
relationship: SCDO:1000210 SCDO:1000114 ! has causal or contributing genetic variation HBB, THR87LYS
relationship: SCDO:1000210 SCDO:1000115 ! has causal or contributing genetic variation HBB, GLU121ALA
relationship: SCDO:1000223 SCDO:1000007 ! has causal molecular phenotype Hemoglobin D
property_value: SCDO:0000303 "Suggest update to description in ORDO" xsd:string
property_value: SCDO:0000340 http://www.doh.wa.gov/Portals/1/Documents/5220/HbDFactSheet.pdf xsd:string
property_value: SCDO:0000340 Orphanet:90039
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000525
name: Hemoglobin D Trait
def: "The inheritance of the gene for hemoglobin D from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." []
synonym: "Hb AD" EXACT []
is_a: NCIT:C95534 ! Hemoglobin Trait
relationship: SCDO:1000172 SCDO:1000226 ! has causal genotype Hemoglobin Genotype AD
relationship: SCDO:1000210 SCDO:1000108 ! has causal or contributing genetic variation HBB, SER9TYR
relationship: SCDO:1000210 SCDO:1000109 ! has causal or contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000210 SCDO:1000110 ! has causal or contributing genetic variation HBB, GLY16ARG
relationship: SCDO:1000210 SCDO:1000111 ! has causal or contributing genetic variation HBB, ASN19LYS
relationship: SCDO:1000210 SCDO:1000112 ! has causal or contributing genetic variation HBB, GLU22GLN
relationship: SCDO:1000210 SCDO:1000113 ! has causal or contributing genetic variation HBB, GLU22VAL
relationship: SCDO:1000210 SCDO:1000114 ! has causal or contributing genetic variation HBB, THR87LYS
relationship: SCDO:1000210 SCDO:1000115 ! has causal or contributing genetic variation HBB, GLU121ALA
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." xsd:string
property_value: SCDO:0000340 http://www.doh.wa.gov/Portals/1/Documents/5220/HbDFactSheet.pdf xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000526
name: deprecated Hemoglobin D-Beta Thalassemia
def: "'Hemoglobin D/xcexb2xc2xb0 thalassemia is a form of beta-thalassemia which results in a mild to moderate clinical picture. The severity of the condition depends on the degree of thalassemia and how it affects production of Hemoglobin A, however this condition is often considered fairly benign.'" []
synonym: "HbD - BT" EXACT []
synonym: "Hemoglobin D Beta-Thalassemia" EXACT []
is_a: SCDO:0000272 ! obsolete Compound Heterozygous Hemoglobinopathy
property_value: SCDO:0000340 http://www.doh.wa.gov/Portals/1/Documents/5220/HbDFactSheet.pdf xsd:string
is_obsolete: true

[Term]
id: SCDO:0000527
name: Hemoglobin D-Ibadan
def: "An unusual hemoglobin that shows all the electrophoretic features of Hb D, but has no inherited disability. This hemoglobin has a beta 87 Thr > Lys mutation." []
synonym: "Hemoglobin D (badan)" EXACT []
is_a: SCDO:1000259 ! Unusual Hemoglobin
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Hemoglobin Variant\"/\"Unusual Hemoglobin\"." xsd:string
property_value: SCDO:0000340 "0062"
property_value: SCDO:0000340 http://dx.doi.org/10.1038/2051273a0
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000528
name: Hemoglobin D-Punjab
def: "An abnormal hemoglobin (one of the types of hemoglobin D) in which glutamine replaces glutamic acid at codon 121 of beta globin." []
synonym: "Haemoglobin D-Punjab" EXACT []
synonym: "Hb D-Los Angelese" EXACT []
synonym: "Hb D-Punjab" EXACT []
synonym: "Hemoglobin D (Chicago)" EXACT []
synonym: "Hemoglobin D (Los Angeles)" EXACT []
synonym: "Hemoglobin D (North Carolina)" EXACT []
synonym: "Hemoglobin D (Portugal)" EXACT []
synonym: "Hemoglobin D (Punjab)" EXACT []
synonym: "Hemoglobin Oak Ridge" EXACT []
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:1000007 ! Hemoglobin D
relationship: SCDO:1000210 SCDO:1000109 ! has causal or contributing genetic variation HBB, GLU121GLN
property_value: SCDO:0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"/\"Hemoglobin D\"." xsd:string
property_value: SCDO:0000340 http://health.utah.gov/nsp/Disorders/HB/Hb_D_Disease_DD/FactSheet_Provider_HbDD_En.pdf xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000529
name: deprecated Hemoglobin Disease Other than C,D,E,F,H,O-Arab,S
def: "A disease caused by atypical hemoglobins molecules other than hemoglobin C,D,E, F, H, O-Arab and S." []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000303 "adapted from description under ID SCDO:0001065" xsd:string
property_value: SCDO:0000340 http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-and-other-than-A-C-D-E-F-H-O-Arab-S xsd:string
property_value: SCDO:0000340 SCDO:0001065 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000530
name: Hemoglobin E Disease
def: "An autosomal recessive haemoglobinopathy characterized by an abnormal form of haemoglobin called haemoglobin E, which disrupts the oxygen-carrying ability of red blood cells. The condition can lead to mild or moderate hemolytic anemia; however, this condition often has no clinical manifestations.\nwith a generally benign, asymptomatic presentation." []
synonym: "Haemoglobin E Disease" EXACT []
synonym: "Hb E-Disease" EXACT []
xref: ORPHA:2133
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
relationship: SCDO:0000663 CHMO:0001009 ! diagnosed using tool High-Performance Liquid Chromatography
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
relationship: SCDO:0000664 SCDO:0001329 ! treated with Folic Acid
relationship: SCDO:0001364 SCDO:1000242 ! has mode of inheritance Autosomal Recessive Homozygous
relationship: SCDO:1000172 SCDO:1000229 ! has causal genotype Hemoglobin Genotype EE
relationship: SCDO:1000218 NCIT:C3833 ! has manifestation Asymptomatic
relationship: SCDO:1000223 SCDO:1000009 ! has causal molecular phenotype Hemoglobin E
property_value: SCDO:0000340 http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-E xsd:string
property_value: SCDO:0000340 https://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=3654&Disease_Disease_Search_diseaseGroup=hemoglobin-E-disease&Disease_Disease_Search_diseaseType=Pat&Disease(s)/group%20of%20diseases=Hemoglobin-E-disease&title=Hemoglobin%20E%20disease&search=Disease_Search_Simple
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000530 xsd:string

[Term]
id: SCDO:0000531
name: Hemoglobin E Trait
def: "The inheritance of the gene for hemoglobin E from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." []
comment: Hb E-carriers generally do not have any signs or symptoms related to abnormal hemoglobin.
synonym: "Hb AE" EXACT []
synonym: "Hb E Trait" EXACT []
is_a: NCIT:C95534 ! Hemoglobin Trait
relationship: SCDO:1000172 SCDO:1000227 ! has causal genotype Hemoglobin Genotype AE
relationship: SCDO:1000210 SCDO:1000042 ! has causal or contributing genetic variation HBB, GLU26LYS
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-A-E
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." xsd:string
property_value: SCDO:0000340 http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-A-E xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000532
name: deprecated Hemoglobin E-Beta Thalassemia
def: "'Hemoglobin E/xcexb2+ thalassemia is a form of beta-thalassemia that is often, but not always, milder than hemoglobin E/xcexb2xc2xb0 thalassemia. This condition shows a marked clinically diverse picture whereby abnormalities of xcexb2-globin chain synthesis result almost asymptomatic anemia to more severe transfusion-dependant anemia (Vichinsky, 2007).'" []
synonym: "Haemoglobin E-Beta Thalassemia" EXACT []
synonym: "Hemoglobin E Beta-Thalassemia" EXACT []
is_a: SCDO:0000272 ! obsolete Compound Heterozygous Hemoglobinopathy
property_value: SCDO:0000340 http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=19177&Disease_Disease_Search_diseaseGroup=Hemoglobin-D-Beta-Thalassemia&Disease_Disease_Search_diseaseType=Pat&Disease(s)/group%20of%20diseases=Hemoglobin-E-beta-thalassemia-syndrome&title=Hemoglobin-E-beta-thalassemia-syndrome&search=Disease_Search_Simple xsd:string
is_obsolete: true

[Term]
id: SCDO:0000533
name: deprecated Hemoglobin F Profile
def: "The score of fetal hemoglobin (Hb F) in the blood of an individual." []
is_a: SCDO:0000359 ! deprecated terms
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Gaston K Mazandu)" xsd:string
property_value: SCDO:0000303 "Description not clear enough." xsd:string
property_value: SCDO:1000288 "None" xsd:string
is_obsolete: true
replaced_by: SCDO:1000707

[Term]
id: SCDO:0000535
name: obsolete Hemoglobin Lepore Baltimore
def: "A variant of Hemoglobin Lepore Syndrome." []
synonym: "Hb Lepore Baltimore" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome xsd:string
is_obsolete: true

[Term]
id: SCDO:0000536
name: Hemoglobin Lepore Boston Disease
def: "A variant of Hemoglobin Lepore Syndrome. Crossover occurs between glutamine at position 87 of delta chain and histidine at position 116 of beta chain. It is associated with unusual high levels of Hb F. This is the only one of the three variants of described in association with HbS." []
synonym: "Hb Lepore Boston Syndrome" EXACT []
synonym: "Hb Lepore Washington Syndrome" EXACT []
synonym: "Hb Lepore Washington-Boston Syndrome" EXACT []
synonym: "Hemoglobin Lepore Boston-Washington" EXACT []
synonym: "Hemoglobin Lepore Washington Syndrome" EXACT []
synonym: "Hemoglobin Lepore Washington-Boston Syndrome" EXACT []
is_a: NCIT:C141366 ! Hemoglobin Lepore Syndrome
relationship: SCDO:0000663 CHMO:0001009 ! diagnosed using tool High-Performance Liquid Chromatography
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0000666 ! diagnosed using tool Isoelectric Focusing
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000172 SCDO:1000236 ! has causal genotype Hemoglobin Lepore Boston Genotype
relationship: SCDO:1000210 SCDO:1000209 ! has causal or contributing genetic variation Crossover between delta (HBD) and beta globin (HBB) gene loci
relationship: SCDO:1000223 SCDO:1000089 ! has causal molecular phenotype Hemoglobin Lepore Boston
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/C039800
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000537
name: obsolete Hemoglobin Lepore Hollandia
def: "A variant of Hemoglobin Lepore Syndrome." []
synonym: "Hb Hollandia" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome xsd:string
is_obsolete: true

[Term]
id: SCDO:0000539
name: Hemoglobin Lepore Trait
def: "The inheritance of the gene for hemoglobin Lepore from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." []
synonym: "Heterozygous Hb Lepore" EXACT []
is_a: SCDO:0000551 ! Thalassemia Trait
relationship: SCDO:1000218 NCIT:C3833 ! has manifestation Asymptomatic
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000540
name: deprecated Hemoglobin Lepore-Beta Thalassaemia
def: "'A form of beta-thalassemia in which the patient is compound heterozygous for hemoglobin lepore and beta-thalassemia, which results in beta-thalassemia intermedia to beta-thalassemia major. [Curator team: []]'" []
synonym: "Hb Lepore-B-Thalassaemia" EXACT []
synonym: "Hemoglobin Lepore-B-Thalassaemia" EXACT []
synonym: "Hemoglobin Lepore-Beta Thalassaemia Syndrome" EXACT []
is_a: SCDO:0000272 ! obsolete Compound Heterozygous Hemoglobinopathy
property_value: SCDO:0000303 "Add HBD to Disease Modifiers (below Gene Product)? And link to it." xsd:string
is_obsolete: true

[Term]
id: SCDO:0000541
name: Hemoglobin M Disease
def: "A type of dominant hereditary methemoglobinemia resulting from the production of hemoglobin M, which is readily oxidised to yield excess methemoglobin which leads to cyanosis." []
synonym: "Autosomal Dominant Congenital Methemoglobinemia Type II" EXACT []
synonym: "Autosomal Dominant Hereditary Methemoglobinemia Type II" EXACT []
synonym: "Hereditary MetHb Type II" EXACT []
synonym: "Hereditary Methemoglobinemia Type II" EXACT []
synonym: "M Hemoglobinopathy" EXACT []
synonym: "Second Form of Inherited MetHb" EXACT []
is_a: SCDO:0000559 ! Hereditary Methemoglobinemia
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:0000663 SCDO:0000436 ! diagnosed using tool Enzymatic Assay
relationship: SCDO:0001364 HP:0000006 ! has mode of inheritance Autosomal Dominant
relationship: SCDO:1000172 SCDO:1000233 ! has causal genotype Hemoglobin Genotype M
relationship: SCDO:1000223 SCDO:1000008 ! has causal molecular phenotype Hemoglobin M
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Suggest update to description in MESH" xsd:string
property_value: SCDO:0000340 "a3"
property_value: SCDO:0000340 http://medlineplus.gov/ency/article/000562.htm xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006449
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:0000542
name: obsolete - Hemoglobin M Trait
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "Hemoglobin M Disease is autosomal dominant, thus does not seem to have a \"trait\" condition." xsd:string
property_value: SCDO:0000303 "Requires definition and source." xsd:string
property_value: SCDO:1000288 "None" xsd:string
is_obsolete: true

[Term]
id: SCDO:0000544
name: Hemoglobin O-Arab Disease
def: "A very rare autosomal recessive hemoglobinopathy characterized by an abnormal form of hemoglobin called hemoglobin O-Arab. It is associated with a mild to moderate anemia." []
synonym: "Hb O-Arab Disease" EXACT []
synonym: "Homozygous Hb O-Arab" EXACT []
synonym: "Homozygous Hemoglobin O-Arab" EXACT []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:0001364 SCDO:1000242 ! has mode of inheritance Autosomal Recessive Homozygous
relationship: SCDO:1000172 SCDO:1000231 ! has causal genotype Hemoglobin Genotype O-Arab
relationship: SCDO:1000210 SCDO:1000040 ! has causal or contributing genetic variation HBB, GLU121LYS
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000016 ! has causal molecular phenotype Hemoglobin O-Arab
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://onlinelibrary.wiley.com/doi/10.1002/pbc.24414/pdf xsd:string
property_value: SCDO:0000340 http://www.wardelab.com/14-3.html
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000545
name: Hemoglobin O-Arab Trait
def: "The inheritance of hemoglobin O-Arab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." []
synonym: "Hb A/O-Arab" EXACT []
synonym: "Hb AO-Arab" EXACT []
synonym: "Heterozygous Hb O-Arab" EXACT []
synonym: "Heterozygous Hemoglobin O-Arab" EXACT []
is_a: NCIT:C95534 ! Hemoglobin Trait
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:1000172 SCDO:1000228 ! has causal genotype Hemoglobin Genotype AO-Arab
relationship: SCDO:1000210 SCDO:1000040 ! has causal or contributing genetic variation HBB, GLU121LYS
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." xsd:string
property_value: SCDO:0000340 http://onlinelibrary.wiley.com/doi/10.1002/pbc.24414/pdf xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000546
name: Hemoglobin Profile
def: "The type and relative amounts of various normal and abnormal hemoglobin types." []
is_a: CMO:0000508 ! Hemoglobin Measurement
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 http://labtestsonline.org/understanding/analytes/sickle/tab/test/ xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000547
name: Hemoglobin Profile Assay
def: "A bioassay that measures and identifies the different types of hemoglobin in the bloodstream. It can be used to identify and characterize the different variants in structure and synthesis of hemoglobin that cause sickle cell disease." []
synonym: "Haemoglobin Characterization" EXACT []
synonym: "Haemoglobinopathy Screen" EXACT []
synonym: "Hb Electrophoresis Plus Solubility" EXACT []
synonym: "Hemoglobin Characterization" EXACT []
synonym: "Hemoglobin Electrophoresis" EXACT []
synonym: "Hemoglobin Electrophoresis plus Solubility" EXACT []
synonym: "Hemoglobin Fractionation" EXACT []
synonym: "Hemoglobinopathy Evaluation" EXACT []
synonym: "Hemoglobinopathy Evaluation Profile Blood Test" EXACT []
synonym: "Hemoglobinopathy Fractionation Profile Blood Test" EXACT []
synonym: "Hemoglobinopathy Screen" EXACT []
xref: phenX:830301
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:0001297 CMO:0000364 ! has essential measure Complete Blood Count
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000740 ! has essential measure Medication Inventory
relationship: SCDO:0001297 SCDO:1000342 ! has essential measure History of Transfusion Diagnostic Instrument
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/830301
property_value: SCDO:0000479 "PhenX protocol: Hemoglobin Characterization #830301" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000547 xsd:string

[Term]
id: SCDO:0000548
name: Hemoglobin S Test
def: "A test to quantify the presence of hemoglobin S in the blood and therefore determine whether a person has sickle cell trait or sickle cell disease." []
synonym: "Hemoglobin S Measurement" EXACT []
synonym: "Sickle Cell Identification" EXACT []
is_a: SCDO:0000522 ! Hemoglobin Variant Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "In SNOMED CT this term is \"Sickle cell identification\".\nRequest inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=31852 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000551
name: Thalassemia Trait
def: "The inheritance of one of the faulty genes that causes thalassemia." []
is_a: NCIT:C95534 ! Hemoglobin Trait
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.nhs.uk/conditions/thalassaemia/carriers/
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000552
name: Hemoglobinopathy
def: "An inherited disorder of the structure and/or synthesis of hemoglobin, with a variable phenotype expression ranging from benign to severe." []
xref: NCIT:C3092
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000303 "Suggest update to description in NCIT" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C3092
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000553
name: obsolete Hemoglobinopathy Toms River
def: "Hemoglobinopathy Toms River, is also known as transient neonatal cyanosis and anemia due to toms river hemoglobin. An important gene associated with Hemoglobinopathy Toms River is HBG2 (Hemoglobin Subunit Gamma 2." []
synonym: "Anemia due to Toms River Hemoglobin" EXACT []
synonym: "Transient Neonatal Cyanosis" EXACT []
is_a: SCDO:0001336 ! from phenotype
is_obsolete: true

[Term]
id: SCDO:0000556
name: Hepatic Span
def: "The distance between the lower border of the liver in the mid-clavicular line, and the upper border of the liver in the mid-clavicular line." []
synonym: "Liver Span" EXACT []
is_a: CMO:0000021 ! Body Morphological Measurement
relationship: SCDO:1000190 SCDO:0000864 ! obtained via diagnostic tool Palpation of Liver
relationship: SCDO:1000190 SCDO:0000882 ! obtained via diagnostic tool Percussion of Liver
property_value: SCDO:0000303 "The description needs to be reviewed by an expert. \nRequest inclusion into Clinical Measurement Ontology, below \"liver size measurement\"." xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Liver_span xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000557
name: obsolete Hepatitis B Test
def: "A test for Hepatitis B Virus." []
synonym: "HBV Test" EXACT []
synonym: "Hepatitis B Virus Test" EXACT []
is_a: SCDO:1000034 ! from diagnostics
property_value: SCDO:0000303 "Which Hepatitis B Test is to be referred to here? (There are various different types below \"Immunology Test\" in the \"Sage Bionetworks Synapse Ontology\")" xsd:string
is_obsolete: true

[Term]
id: SCDO:0000558
name: obsolete Hepatitis C Test
def: "A test for Hepatitis C Virus." []
is_a: SCDO:1000034 ! from diagnostics
property_value: SCDO:0000303 "Is this test for viral load measurement or or antibody measurement? (See terms below \"Immunology Test\" in the \"Sage Bionetworks Synapse Ontology\")" xsd:string
is_obsolete: true

[Term]
id: SCDO:0000559
name: Hereditary Methemoglobinemia
def: "A rare red cell disorder classified principally into two clinical phenotypes: autosomal recessive congenital (or hereditary) methemoglobinemia types I and II (RCM/RHM type 1; RCM/RHM type 2)." []
synonym: "Congenital Methemoglobinemia" EXACT []
synonym: "Hereditary MetHb" EXACT []
synonym: "HM" EXACT []
xref: ORPHA:621
is_a: SCDO:0000753 ! Methemoglobinemia
property_value: SCDO:0000340 http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=3290&disease=Hereditary-methemoglobinemia&search=Disease_Search_Simple xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000559 xsd:string

[Term]
id: SCDO:0000564
name: Hip Replacement Arthroplasty
def: "Replacement of the hip joint." []
synonym: "Hip Prosthesis Implantation" EXACT []
synonym: "Hip Replacement Arthroplasty" EXACT []
synonym: "Hip Replacements, Total" EXACT []
synonym: "Replacement Arthroplasties, Hip" EXACT []
synonym: "Total Hip Replacement" EXACT []
xref: MESH:D019644
is_a: SCDO:0001129 ! Supportive Therapeutics
is_a: SCDO:0001133 ! Symptomatic Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D019644 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000564 xsd:string

[Term]
id: SCDO:0000565
name: Historically Controlled Study
def: "A study that compares a group of participants receiving an intervention with a similar group from the past who did not." []
xref: MESH:D065386
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D065386 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000565 xsd:string

[Term]
id: SCDO:0000566
name: History of Head Trauma Diagnostic Instrument
def: "A questionnaire to determine whether an individual has had a traumatic brain injury (TBI)." []
synonym: "History of Head Trauma Questionnaire" EXACT []
xref: phenX:130600
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000303 "Suggest update to label as we have done. We are using \"History of Head Trauma\" below Personal Attribute." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F130600
property_value: SCDO:0000479 "PhenX protocol: History of Head Trauma #130601" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000567
name: History of Kidney Failure Diagnostic Instrument
def: "A questionnaire to determine if the respondent has a history of kidney failure." []
synonym: "History of Kidney Failure Questionnaire" EXACT []
xref: phenX:140600
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 CMO:0000003 ! has essential measure Blood Pressure Measurement
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000570 ! has essential measure History of Type I and Type 2 Diabetes Diagnostic Instrument
property_value: SCDO:0000303 "Link to? \n-- Kidney Failure \n-- Personal Attribute---> Personal medical history --> History of Kidney Failure" xsd:string
property_value: SCDO:0000303 "Suggest update to label as we have done. We are using \"History of Kidney Failure\" below Personal Attribute." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/140601
property_value: SCDO:0000479 "PhenX protocol: Personal History of Kidney Failure #140601" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000568
name: History of Stroke - Ischemic Infarction and Hemorrhage - Diagnostic Instrument
def: "A questionnaire to determine if the respondent has had an ischemic infarction (i.e. stroke) and/or any symptoms related to this event." []
synonym: "History of Stroke - Ischemic Infarction and Hemorrhage - Questionnaire" EXACT []
xref: phenX:130300
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000303 "Suggest update to label as we have done. We are using \"History of Stroke\" below Personal Attribute." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F130300
property_value: SCDO:0000479 "PhenX protocol: History of Stroke - Ischemic Infarction and Hemorrhage #130301" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000570
name: History of Type I and Type 2 Diabetes Diagnostic Instrument
def: "A questionnaire to determine a respondent's history of type 1 or type 2 diabetes." []
xref: phenX:140500
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000987 ! has essential measure Reproductive History Diagnostic Instrument
property_value: SCDO:0000303 "Link to? -- Personal Attribute---> Personal medical history --> History of Type I and Type 2 Diabetes" xsd:string
property_value: SCDO:0000303 "Suggest update to label as we have done. We are using \"History of Type I and Type 2 Diabetes\" below Personal Attribute." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F140500
property_value: SCDO:0000479 "PhenX protocol: Personal History of Type 1 and Type 2 Diabetes #140501" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000571
name: HIV Test
def: "A bioassay to measure human immunodeficiency virus (HIV) antibodies and/or HIV antigens in order to determine whether an individual has an HIV infection." []
synonym: "HIV Assay" EXACT []
synonym: "Human Immunodeficiency Virus Assay" EXACT []
synonym: "Human Immunodeficiency Virus Test" EXACT []
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Also below \"Immunochemical Assay\"?" xsd:string
property_value: SCDO:0000340 https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/19/47/hiv-testing
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/160901
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000572
name: Hospital Anxiety and Depression Scale (HADS)
def: "The HADS consists of 2 subscales each with 7 items for measuring anxiety, and 7 items for depression rated from 0 - 3. Anxiety and depression scores are obtained by adding up the ratings of the items on each subscale. A score above 8 in any of the subscales indicates that the patient has experienced clinically significant anxiety or depression over the past week." []
synonym: "HADS" EXACT []
synonym: "HADS Questionnaire" EXACT []
synonym: "HADS01" EXACT []
synonym: "Hospital Anxiety and Depression Scale" EXACT []
synonym: "Hospital Anxiety and Depression Scale Questionnaire" EXACT []
synonym: "Hospital Anxiety and Depression Scale Questionnaire (HADS)" EXACT []
xref: NCIT:C103520
is_a: SCDO:0000951 ! Quality of Life and Care Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/source http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C103520
property_value: SCDO:0000340 "Zigmond A.S. and Snaith R.P. (1983). The hospital anxiety and depression scale. Acta Psychiatry Scandinavia, 67, 361-370.                                           Anie, K.A.; Green, J.; Tata, P.; Fotopoulos, C. E.; Oni, L. and Davies, S. C. (2002) Self-help manual-assisted cognitive behavioural therapy for sickle cell disease. Behavioural and Cognitive Psychotherapies, 30, 451-458" xsd:string
property_value: SCDO:0000470 "multiple" xsd:string
property_value: SCDO:0000481 "Patient Reported Outcome" xsd:string
property_value: SCDO:0000482 "Clinic Patients" xsd:string
property_value: SCDO:0001033 "Widely used around the world, also used in SCD" xsd:string
property_value: SCDO:0001222 "Adults (18 to 91 years)" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000573
name: Hospitalization
def: "The confinement of a patient in a hospital." []
synonym: "Hospital Admission" EXACT []
synonym: "Hospitalisation" EXACT []
synonym: "Hospitalisations" EXACT []
synonym: "Hospitalizations" EXACT []
xref: MESH:D006760
is_a: SCDO:0000493 ! Health Service Utilization
property_value: SCDO:0000303 "Perhaps \"Hospital Utilization\" would be better here?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006760 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000573 xsd:string

[Term]
id: SCDO:0000574
name: Household Roster-Relationships
def: "A record of those living in the respondent's household and about his or her relationship with them." []
xref: phenX:11400
is_a: NCIT:C16495 ! Demographic Factor
is_a: SCDO:0001090 ! Socioeconomic Factors
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000307 ! has essential measure Current Marital Status
property_value: SCDO:0000303 "Request inclusion into MESH below \"Social Conditions\"?" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/11402
property_value: SCDO:0000479 "PhenX protocol: Household Roster-Relationships #11402" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000576
name: Hydration Therapy
def: "A unique treatment that administers electrolyte-packed IV fluids directly into a patient's bloodstream. Depending on the patient's needs, the fluid may be enhanced with additives such as calcium, magnesium sulfate or a Vitamin B complex. It is a far more efficient method of absorption when compared to the traditional method of drinking liquids/electrolytes." []
xref: NCIT:C66896
is_a: NCIT:C15900 ! Lifestyle Therapy
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1000018 DOID:1584 ! treats Acute Chest Syndrome
relationship: SCDO:1000018 HP:0001953 ! treats Diabetic Ketoacidosis
relationship: SCDO:1000018 SCDO:0000812 ! treats Non-specific Acute Lower Respiratory Tract Episode
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/source http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C66896
property_value: SCDO:0000303 "Suggest update to description in NCIT (currently no description)" xsd:string
property_value: SCDO:0000340 https://recoveryhydrationtherapy.com/what-is-hydration-therapy/
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000580
name: Hydroxyurea
def: "An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase." []
synonym: "Hydrea" EXACT []
synonym: "Hydroxycarbamide" EXACT []
synonym: "Oncocarbide" EXACT []
xref: MESH:D006918
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1000015 SCDO:0000251 ! modifies Clinical Phenotype of Beta Thalassemia
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
relationship: SCDO:1000015 SCDO:1000707 ! modifies Hemoglobin F Level
relationship: SCDO:1000018 DOID:1584 ! treats Acute Chest Syndrome
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 HP:0000112 ! treats Nephropathy
relationship: SCDO:1000018 NCIT:C129072 ! treats Hereditary Persistence of Fetal Hemoglobin
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1000018 NCIT:C155312 ! treats Sickle Cell Chronic Lung Disease
relationship: SCDO:1000018 SCDO:0000519 ! treats Hemoglobin C Disease
relationship: SCDO:1000018 SCDO:0000530 ! treats Hemoglobin E Disease
relationship: SCDO:1000018 SCDO:0000972 ! treats Recurrent Wheeze in Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006918
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000580 xsd:string

[Term]
id: SCDO:0000581
name: Hydroxyurea-Induced Adverse Event
def: "A causal adverse drug event that is induced by hydroxyurea." []
is_a: SCDO:0000191 ! Causal Adverse Drug Event
relationship: SCDO:1000199 SCDO:0000580 ! induced by Hydroxyurea
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into OAE below \"Causal Adverse Drug Event\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000582
name: Hydroxyurea-Induced Cutaneous Adverse Event
def: "A hydroxyurea-induced adverse event that has an outcome relating to or affecting the skin." []
is_a: SCDO:0000581 ! Hydroxyurea-Induced Adverse Event
relationship: SCDO:1000199 SCDO:0000580 ! induced by Hydroxyurea
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into OAE below \"Hydroxyurea-Induced Adverse Event\" (also suggested by us for inclusion).\nOr \nObsolete and use an object property (has adverse events) to link Hydroxyea to Cutaneous." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000583
name: Hydroxyurea-Induced Splenomegaly Adverse Event
def: "A hydroxyurea-induced adverse event that has the outcome of splenomegaly." []
is_a: SCDO:0000581 ! Hydroxyurea-Induced Adverse Event
relationship: SCDO:1000199 SCDO:0000580 ! induced by Hydroxyurea
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into OAE below \"Hydroxyurea-Induced Adverse Event\" (also suggested by us for inclusion).\nOr\nDelete and use an object property (has adverse events) to link Hydroxyea to Splenomegaly." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000588
name: Hyperkalemia
def: "Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)." []
synonym: "High Blood Potassium Levels" EXACT []
synonym: "Hyperkalemias" EXACT []
synonym: "Hyperpotassemia" EXACT []
synonym: "Hyperpotassemias" EXACT []
xref: MESH:D006947
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006947 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000588 xsd:string

[Term]
id: SCDO:0000593
name: Hyperpigmentation
def: "Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance." []
synonym: "Hypermelanoses" EXACT []
synonym: "Hypermelanosis" EXACT []
synonym: "Hyperpigmentation of the skin" EXACT []
synonym: "Skin Hyperpigmentation" EXACT []
xref: MESH:D017495
is_a: HP:0011121 ! Abnormality of Skin Morphology
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017495
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000593 xsd:string

[Term]
id: SCDO:0000598
name: Hypnotics and Sedatives
def: "Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety." []
synonym: "Hypnotics" EXACT []
synonym: "Sedatives" EXACT []
synonym: "Sedatives and Hypnotics" EXACT []
xref: MESH:D006993
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001129 ! Supportive Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006993 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000598 xsd:string

[Term]
id: SCDO:0000607
name: ICD-10-CM Diagnosis Codes
def: "The ICD-10-CM diagnosis classification system developed by the Centers for Disease Control and Prevention for use in all U.S. health care treatment settings. Diagnosis coding under this system uses a different number of digits and some other changes, but the format is very much the same as ICD-9-CM. The National Center for Health Statistics (NCHS), the Federal agency responsible for use of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10) in the United States, has developed a clinical modification of the classification for morbidity purposes. The ICD-10 is used to code and classify mortality data from death certificates, having replaced ICD-9 for this purpose as of January 1, 1999. ICD-10-CM is the replacement for ICD-9-CM, volumes 1 and 2, effective October 1, 2015." []
is_a: SCDO:0000245 ! Clinical Coding
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps below \"Clinical Coding\" in MESH." xsd:string
property_value: SCDO:0000340 https://www.cdc.gov/nchs/icd/icd10cm.htm xsd:string
property_value: SCDO:0000340 https://www.findacode.com/icd-10-cm/icd-10-cm-diagnosis-codes-set.html xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000611
name: Illness Perception Questionnaire Revised (IPQ-R)
def: "The IPQ-R is an 84-item self-completed instrument developed to provide a quantitative measurement of the components of illness representations, as described by Leventhal's Common-Sense Model (CSM) of selfregulation it is divided into 3 sections: identity subscale (14 symptoms), causal subscale (18 causes), and a third section which contains 7 subscales, including consequences, timeline acute/chronic and cyclical, personal and treatment control/cure, illness coherence, and emotional representations. The questionnaire wording can be adapted to the specific illness by replacing the word illness with the name of the condition. For the identity subscale, respondents are asked if they have experienced a number of symptoms since their illness, and if they feel the symptoms are related to their current illness. Response is by circling 'yes' or 'no' to each question. Responses are then summed to give an overall score. For the causal subscale, respondents are asked what they perceive to be the cause of their illness and are asked to respond to each of the listed causes using a 5-point Likert style scale, ranging from strongly disagree to strongly agree. Respondents are also asked to rank the 3 most important factors believed to be the cause of their illness. The third section (7 subscales) is scored by summing responses to each item is on a 5-point Likert style scale, ranging from strongly disagree to strongly agree. All items for each of the subscales are summed to give an overall score. High scores on the identity, consequences, timeline acute/chronic and cyclical subscales represent strongly held beliefs about the number of symptoms attributed, the negative consequences, and the chronicity and cyclical nature of the illness. High scores on the personal and treatment control and coherence subscales represent positive beliefs about controllability and a personal understanding of the illness." []
synonym: "Illness Perception Questionnaire Revised" EXACT []
synonym: "IPQ-R" EXACT []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: http://purl.org/dc/elements/1.1/source "Moss-Morris R, Weinman J, Petrie KJ, Horne R, Cameron LD, Buick D (2002). The Revised Illness Perception Questionnaire (IPQ-R). Psychol Health 17:1-16." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Moss-Morris R, Weinman J, Petrie KJ, Horne R, Cameron LD, Buick D (2002). The Revised Illness Perception Questionnaire (IPQ-R). Psychol Health 17:1-16." xsd:string
property_value: SCDO:0000470 "multiple" xsd:string
property_value: SCDO:0000481 "Patient Reported Outcome" xsd:string
property_value: SCDO:0000482 "Clinic Patients" xsd:string
property_value: SCDO:0000484 "many" xsd:string
property_value: SCDO:0001033 "Good psychometric properties, widely used around the world, has been translated into several languages." xsd:string
property_value: SCDO:0001222 "Adults" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000615
name: deprecated Immune System
def: "The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components." []
xref: MESH:D007107
is_a: SCDO:0000511 ! obsolete Hemic and Immune Systems
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007107 xsd:string
is_obsolete: true
replaced_by: SCDO:1000273

[Term]
id: SCDO:0000616
name: Immunochemical Assay
def: "An assay that identifies a substance (especially a protein) by its action as an antigen." []
is_a: NCIT:C16723 ! Immunological Assay
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.thefreedictionary.com/immunochemical+assay
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000618
name: Immunosuppressant Drug Level Decreased AE
def: "A drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body." []
xref: OAE:0001071
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0001071 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000618 xsd:string

[Term]
id: SCDO:0000619
name: Immunoturbidimetry Assay
def: "An assay that employs immunoturbidimetry, a method that measures the absorbance of light from a sample which is used for quantifying an amount of analyte based on the level of turbidity produced by the formation and precipitation of an immune complex containing the analyte." []
synonym: "Immunoturbidimetry Test" EXACT []
is_a: NCIT:C16723 ! Immunological Assay
property_value: SCDO:0000303 "Request inclusion into relevant ontology. NCIT contains \"Immunoturbidimetry\", but not \"Immunoturbidimetry Assay\". Do we rather want to have this term as \"Immunoturbidimetry\"?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C106536 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000643
name: Insect Repellents
def: "Substances causing insects to turn away from them or reject them as food." []
xref: MESH:D007302
is_a: SCDO:0000709 ! Malaria Prophylaxis
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007302 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000643 xsd:string

[Term]
id: SCDO:0000649
name: Intelligence Scale - Birth to 3.5 years
def: "A standardized tool designed to assess a child's development as compared to same-age peers. It has components that involve both direct observation and interaction with a child as well as caregiver questionnaires. It consists of five domains (cognitive, motor, language, social-emotional, and adaptive behavior)." []
synonym: "Bayley Scale of Infant Development III" EXACT []
synonym: "Bayley Scales of Infant and Toddler Development, Third Edition" EXACT []
synonym: "Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III)" EXACT []
synonym: "Bayley-III" EXACT []
xref: NCIT:C99150
is_a: NCIT:C122920 ! Intelligence Scale
property_value: SCDO:0000303 "Life stage: Infant, Toddler, Child" xsd:string
property_value: SCDO:0000303 "Suggest update to description in NCIT (we're not using their description, but their description says \"from one to twenty-four months of age\")" xsd:string
property_value: SCDO:0000303 "The Sickle Cell Disease Neurology, Quality of Life, and Health Services Working Group recognizes that there is an age overlap between the Bayley-III and the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI - IV). The Working Group recommends that providers use their clinical judgment, consider the purpose of testing participants, and refer to the frequently asked questions section of the Pearson website for Bayley-III and the WPPSI-IV for guidance on selecting an age-appropriate test." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820504 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Intelligence Scale - Birth to 3.5 years #820504" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000650
name: Intentional Drug Misuse AE
def: "An adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc)." []
xref: OAE:0001093
is_a: SCDO:0000028 ! Adverse Drug Event
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0001093 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000650 xsd:string

[Term]
id: SCDO:0000651
name: Interrupted Time Series Analysis
def: "A study that uses observations at multiple time points before and after an intervention (the interruption), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time." []
synonym: "ITS Studies" EXACT []
xref: MESH:D065186
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D065186 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000651 xsd:string

[Term]
id: SCDO:0000653
name: deprecated-Intracerebral Haemorrhage
def: "Intracerebral hemorrhage (ICH) is when blood suddenly bursts into brain tissue, causing damage to the brain." []
synonym: "Intracerebral Bleeding" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000303 "Should this term be merged with \"Cerebral Hemorrhage\" and \"Intracerebral Haemorrhage\" made a synonym of \"Cerebral Hemorrhage\"? --  -- Specify description source and source for additional info." xsd:string
is_obsolete: true
replaced_by: SCDO:0000209

[Term]
id: SCDO:0000656
name: Intracranial Hypotension
def: "CSF pressure less than 6 cm of H2O in patients with clinical presentation compatible with intracranial hypotension, which are postural headache, nausea, vomiting, neck pain, visual and hearing disturbances, and vertigo. It most commonly results from CSF leaks somewhere along the neuraxis." []
synonym: "Craniospinal Hypotension" EXACT []
synonym: "Decreased Intracranial Pressure" EXACT []
xref: DOID:4723
is_a: HP:0012638 ! Abnormal Nervous System Physiology
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
property_value: http://purl.org/dc/elements/1.1/source http://radiopaedia.org/articles/intracranial-hypotension-1
property_value: SCDO:0000303 "Suggest update to description in DOID (currently no description)" xsd:string
property_value: SCDO:0000340 https://radiopaedia.org/articles/intracranial-hypotension-1
property_value: SCDO:0000468 "Spontaneous intracranial hypotension is typically encountered in middle age (30-50 years of age) and has a predilection for women (F:M 2:1). Of interest, this is a similar demographic to pseudotumour cerebri, which is believed to be an unrecognised predisposing factor. Epidemiology of secondary intracranial hypotension is variable and matches that of the underlying cause." xsd:string
property_value: SCDO:0000472 "Intracranial hypotension can broadly be divided into: 1.Primary: usually referred to as spontaneous intracranial hypotension. 2. Secondary: iatrogenic (LP or surgery), over shunting due to diversion devices or traumatic." xsd:string
property_value: SCDO:0000662 "Generally, there are no localising symptoms forms directly from the leak, as CSF is absorbed into tissues. The condition often presents as a positional headache which is relieved by a recumbent position, usually within 15-30min. It is confirmed by assessing opening pressure on LP (less than 7 cm CSF). Note that when this is done fluoroscopically, it should be performed in a lateral position to allow for accurate measurement of pressure. Occasionally presentation is more sinister, with even decreased level of consciousness and coma reported." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000657
name: Intraosseous Pressure
def: "The hydrostatic pressure of venous blood in the marrow of bones." []
synonym: "IOP" EXACT []
is_a: SCDO:0000728 ! Diagnostic Measurement
relationship: SCDO:1000193 SCDO:0000710 ! output of diagnostic device Manometer
property_value: SCDO:0000303 "Term should be requested for inclusion into the \"Ontology of Biological Attributes\", perhaps in an appropriate location under \"organ system trait\". Or perhaps below \"bone measurement\" or \"bone marrow measurement\" in the CMO?" xsd:string
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/intraosseous xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/pubmed/6456552 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000665
name: Ischemia
def: "A hypoperfusion of the blood through an organ or tissue caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation." []
synonym: "Ischemias" EXACT []
xref: MESH:D007511
is_a: HP:0001626 ! Abnormality of Cardiovascular System
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Should this be under \"Abnormal Cardiovascular System Morphology\" or \"\"Abnormal Cardiovascular System Physiology\"?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007511 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000665 xsd:string

[Term]
id: SCDO:0000666
name: Isoelectric Focusing
def: "Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point." []
synonym: "Electrofocusing" EXACT []
synonym: "IEF" EXACT []
xref: MESH:D007525
is_a: SCDO:0000424 ! Electrophoresis
is_a: SCDO:1000577 ! Type of SCD Test
property_value: http://purl.org/dc/elements/1.1/source http://labtestsonline.org/understanding/analytes/hemoglobin-var/tab/test/
property_value: SCDO:0000303 "Perhaps change label to \"Hemoglobin Isoeletcric Focusing\"? Exactsynonym \"Hb IEF\". See dc:source provided." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007525 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000666 xsd:string

[Term]
id: SCDO:0000676
name: Kidney Function Test
def: "Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine." []
synonym: "Kidney Function Tests" EXACT []
synonym: "Renal Function Test" EXACT []
synonym: "Renal Function Tests" EXACT []
xref: MESH:D007677
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007677 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000676 xsd:string

[Term]
id: SCDO:0000677
name: Kinesiotherapy
def: "A specialized area of medicine in which exercise and movement are used as the primary form of rehabilitation." []
is_a: SCDO:0000978 ! Rehabilitation
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/kinesiotherapy xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000678
name: Knowledge about Sickle Cell Disease
def: "Collections of facts, assumptions, beliefs and practices that health professionals hold about the aetiology, pathophysiology, quality management of SCD and related social support systems based on global standards." []
is_a: SCDO:0000246 ! Clinical Competence
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Probably too specific to SCD to be included in other ontologies." xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/mesh/?term=base%2C+knowledge; xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/20353928 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000682
name: Lactate Dehydrogenase Level
def: "The level of lactate dehydrogenase, an enzyme released during tissue damage and injury, found in a specified biological specimen." []
comment: Normal and abnormal ranges given here: https://www.healthline.com/health/lactate-dehydrogenase-test#results
synonym: "Lactate Dehydrogenase Levels" EXACT []
synonym: "Lactic Acid Dehydrogenase Level" EXACT []
synonym: "LD Level" EXACT []
synonym: "LDH Level" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000683 ! obtained via diagnostic tool Lactate Dehydrogenase Test
relationship: SCDO:1000190 SCDO:0001230 ! obtained via diagnostic tool Venipuncture
relationship: SCDO:1000772 HP:0025435 ! has possible finding Increased Lactate Dehydrogenase Level
relationship: SCDO:1000772 SCDO:1000684 ! has possible finding Reduced Lactate Dehydrogenase Level
relationship: SCDO:1000772 SCDO:1000833 ! has possible finding Normal Lactate Dehydrogenase Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\nShould this term's name be changed to \"L-Lactate Dehydrogenase Level\"?" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000683
name: Lactate Dehydrogenase Test
def: "A bioassay to measure levels of lactate dehydrogenase, an enzyme released during tissue damage and injury." []
synonym: "Lactate Dehydrogenase Level Test" EXACT []
synonym: "Lactic Acid Dehydrogenase Test" EXACT []
synonym: "LDH Test" EXACT []
xref: phenX:811001
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000194 SCDO:0000682 ! measures Lactate Dehydrogenase Level
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Lactate Dehydrogenase Level\")." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/811001
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000685
name: Leg Ulcer
def: "Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (varicose ulcer), 5% to arterial disease, and the remaining 5% to other causes." []
synonym: "Leg Ulcers" EXACT []
xref: MESH:D007871
is_a: HP:0200042 ! Skin Ulcer
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007871 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000685 xsd:string

[Term]
id: SCDO:0000689
name: Lifestyle
def: "Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)." []
synonym: "Life Style" EXACT []
xref: MESH:D008019
is_a: SCDO:0000487 ! Health Behaviour
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008019 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000689 xsd:string

[Term]
id: SCDO:0000691
name: Light Coagulation
def: "The coagulation of tissue by an intense beam of light, including laser (laser coagulation). In the eye it is used in the treatment of retinal detachments, retinal holes, aneurysms, hemorrhages, and malignant and benign neoplasms. (Dictionary of Visual Science, 3d ed)" []
synonym: "Light Coagulations" EXACT []
synonym: "Photocoagulation" EXACT []
synonym: "Photocoagulations" EXACT []
xref: MESH:D008028
is_a: SCDO:0000833 ! Ophthalmologic Surgical Procedure
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008028 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000691 xsd:string

[Term]
id: SCDO:0000694
name: Liver Examination
def: "Any process carried out to determine the condition of a patient's liver." []
xref: IDODEN:0003652
is_a: SCDO:0000898 ! Physical Examination
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/IDODEN?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FIDODEN_0003652 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000694 xsd:string

[Term]
id: SCDO:0000698
name: Locus of Control
def: "Personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behaviour versus fate, luck, or external forces." []
synonym: "Control Locus" EXACT []
synonym: "External-Internal Control" EXACT []
synonym: "Health Locus of Control" EXACT []
synonym: "Internal-External Control" EXACT []
synonym: "Sense of Control" EXACT []
xref: MESH:D007389
is_a: SCDO:0000488 ! Health Beliefs
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007389 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000698 xsd:string

[Term]
id: SCDO:0000699
name: Longitudinal Studies
def: "Studies in which variables relating to an individual or group of individuals are assessed over a period of time." []
synonym: "Heart Study, Jackson" EXACT []
xref: MESH:D008137
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008137 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000699 xsd:string

[Term]
id: SCDO:0000702
name: Lot Quality Assurance Sampling
def: "A sampling methodology using small sample sizes when conducting surveys in small geographical or population-based areas or lots." []
synonym: "LQAS" EXACT []
xref: MESH:D055810
is_a: SCDO:0300004 ! Epidemiologic Study Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055810 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000702 xsd:string

[Term]
id: SCDO:0000704
name: Lung Volume Measurement
def: "Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle." []
synonym: "Lung Capacities" EXACT []
synonym: "Lung Capacity" EXACT []
synonym: "Lung Volume" EXACT []
synonym: "Lung Volume Measurements" EXACT []
xref: MESH:D008176
is_a: CMO:0000094 ! Respiratory System Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000149 ! has essential measure Body Height
relationship: SCDO:0001297 SCDO:0000152 ! has essential measure Body Weight
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 NCIT:C85397 ! obtained via diagnostic tool Spirometry
relationship: SCDO:1000190 SCDO:0000705 ! obtained via diagnostic tool Lung Volume Test
relationship: SCDO:1000193 SCDO:0001099 ! output of diagnostic device Spirometer
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Perhaps use the \"DEFINITIONS AND SUBDIVISIONS OF LUNG VOLUME\" section in the \"Lung Function - Lung Volume #810401\" protocol source in PhenX to include types of lung volume as subclasses. Can also use subclasses of Experimental Factor Ontology -- (EFO) term \"pulmonary function measurement or sub-classes of \"Lung Volume Measurements\" in MESH." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008176 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000704 xsd:string

[Term]
id: SCDO:0000705
name: Lung Volume Test
def: "Clinical assessment to determine the volume of gas within an individual's lung." []
synonym: "Lung Function - Lung Volume" EXACT []
synonym: "Lung Volume Assay" EXACT []
synonym: "Pulmonary Volume Assay" EXACT []
synonym: "Pulmonary Volume Test" EXACT []
xref: phenX:810401
is_a: SCDO:0000942 ! Pulmonary Function Test
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000149 ! has essential measure Body Height
relationship: SCDO:0001297 SCDO:0000152 ! has essential measure Body Weight
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000192 SCDO:0001099 ! uses diagnostic device Spirometer
relationship: SCDO:1000194 SCDO:0000704 ! measures Lung Volume Measurement
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Lung Function - Lung Volume\")\n\nPerhaps use the protocol source in PhenX to include different ways of measuring FRC (functional residual capacity) as subclasses (e.g. Measurement of FRC using body plethysmography, Measurement of FRC using nitrogen washout, Measurement of FRC using helium dilution, Measurement of lung volume using imaging techniques).\n\nSNOMED has more terms below \"Lung Volume Test\"\n\nLink to necessary medical device." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810401
property_value: SCDO:0000479 "PhenX protocol: Protocol - Lung Function - Lung Volume #810401" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000706
name: obsolete Lymphoid System
def: "'The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system. [Curator team: []]'" []
xref: UBERON:0002465
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/UBERON_0002465 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000709
name: Malaria Prophylaxis
def: "The use of drugs or other agents to prevent malarial infection. Examples: Proguanil, mefloquine, artesunate, insect repellant, insecticide-treated-bednet." []
synonym: "Malaria Prevention" EXACT []
is_a: SCDO:0000930 ! Infection Prophylaxis
relationship: SCDO:1000018 HP:0002725 ! treats Systemic Lupus Erythematosus
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.cdc.gov/malaria/travelers/drugs.html xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000710
name: Manometer
def: "An instrument that is used for measuring the pressure of liquids and gases." []
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:0000474 SCDO:0000657 ! has output measurement Intraosseous Pressure
property_value: SCDO:0000303 "Request inclusion into \"Eagle-I Research Resource Ontology\", below the \"instrument\" term.\n\nPerhaps the specific manometer used for measuring \"Intraosseous Pressure\" should be added as a sub-class and linked to directly." xsd:string
property_value: SCDO:0000340 http://www.dictionary.com/browse/manometer xsd:string
property_value: SCDO:0000340 "The American Heritage Science Dictionary. Retrieved October 20, 2016 from Dictionary.com website" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000711
name: Marital Status of Primary Caregiver
def: "The current marital status of the respondent's caregiver (i.e. family member or another individual who takes primary responsibility for the respondent)." []
xref: phenX:840101
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:0001090 ! Socioeconomic Factors
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Request inclusion into MESH below \"Family Characteristics\"." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/840101
property_value: SCDO:0000479 "PhenX protocol: Marital Status of Primary Caregiver #840101" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000725
name: Measure of Frequency of Sickle Cell Pain Episodes
def: "A questionnaire to capture the frequency of acute pain episodes within a defined time frame due to sickle cell disease (SCD). It includes three self-administered questions from the Cooperative Study of Sickle Cell Disease (CSSCD) that capture number of painful episodes that required visits to the emergency room or hospital or interfered with daily activities." []
xref: phenX:830100
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to label in PhenX as we have done here because we have used \"Frequency of Sickle Cell Pain Episodes Per Year\" for the Diagnostic Instrument Measurement." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/830101
property_value: SCDO:0000479 "PhenX protocol: Frequency of Sickle Cell Pain Episodes Per Year #830101" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000726
name: Measure of Sickle Cell Stigma (MoSCS)
def: "Measure of disease specific stigma based on patient reported outcome measurements that assesses 4 MoSCS factors: Social exclusion, Internalized Stigma, Expected Discrimination and Disclosure concerns. Measure includes stigma scores; perceived disease severity, acute care service utilization, hospital admission levels. N=262." []
synonym: "Measure of Sickle Cell Stigma" EXACT []
synonym: "MoSCS" EXACT []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: http://purl.org/dc/elements/1.1/source "Bediako, Shawn M et al. “The Measure of Sickle Cell Stigma: Initial Findings from the Improving Patient Outcomes through Respect and Trust Study.” Journal of health psychology (2014): 1359105314539530. PMC. Web. 13 Mar. 2016. PMCID: PMC4627860" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "J Health Psychol. 2016 May; 21(5): 808–820." xsd:string
property_value: SCDO:0000470 "African-Americans" xsd:string
property_value: SCDO:0000481 "Patient Reported Outcome" xsd:string
property_value: SCDO:0000482 "Adults with Sickle Cell Disease" xsd:string
property_value: SCDO:0001222 "Adults 18 years and older" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000727
name: Measured Weight
def: "The weight of the participant in kilograms." []
is_a: SCDO:0000152 ! Body Weight
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000728
name: Diagnostic Measurement
def: "An information entity used in the diagnosis of medical conditions. It could be the recording of the output of a diagnostic device or the outcome of a diagnostic tool." []
synonym: "Diagnostic Quantitative Measurement" EXACT []
is_a: SCDO:0000379 ! Diagnostics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000737
name: Medical Outcomes Study (MOS) Social Support Survey
def: "The MOS Social Support Survey is a self-administered questionnaire that includes 19 items across four functional support subscales: emotional/informational support (8 items), tangible/instrumental support (4 items), affectionate support (3 items), and positive social interaction (3 items). Each item is scored on a 5-point Likert style scale (1 = None of the Time; 5 = All of the Time) to indicate how often that type of support is available to them. A score for each social support subscale can be computed by averaging across the individual items or by adding scores individual items together. Higher scores indicate more support." []
synonym: "Medical Outcomes Study Social Support Survey" EXACT []
synonym: "MOS Social Support Survey" EXACT []
xref: NCIT:C110969
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: http://purl.org/dc/elements/1.1/source http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C110969
property_value: http://purl.org/dc/elements/1.1/source http://www.rand.org/pubs/reprints/RP218.html
property_value: SCDO:0000303 "Check and show which source was used for the description and whether the description was adapted from the source." xsd:string
property_value: SCDO:0000303 "Suggest update to description in NCIT for \"Medical Outcomes Study Social Support Survey\"." xsd:string
property_value: SCDO:0000340 "Sherbourne CD, Stewart A. The MOS Social Support Survey. Social Science and Medicine, v. 32, 1991, pp. 705-714." xsd:string
property_value: SCDO:0000340 "Sherbourne, Cathy D. and Anita Stewart. The MOS Social Support Survey. Santa Monica, CA: RAND Corporation, 1993." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic patients" xsd:string
property_value: SCDO:0001222 "Adults 18 years and older" xsd:string
property_value: SCDO:0001335 "no" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000738
name: Medical Records
def: "Recording of pertinent information concerning patient's illness or illnesses." []
xref: MESH:D008499
is_a: SCDO:0000948 ! Quality of Health Care
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008499 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000738 xsd:string

[Term]
id: SCDO:0000739
name: Medication Adherence
def: "Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency." []
xref: MESH:D055118
is_a: SCDO:0000869 ! Patient Compliance
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055118 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000739 xsd:string

[Term]
id: SCDO:0000740
name: Medication Inventory
def: "A record of the type and dosage of all prescription and over-the-counter medications as well as dietary supplements currently being taken by the individual." []
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:1000157 ! Quality of Life Related Personal Attribute
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/140301
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nWould it also be appropriate to add this to \"Diagnostic Instrument\" below \"Diagnostics\"?" xsd:string
property_value: SCDO:0000479 "PhenX protocol: Medication Inventory #140301" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0000741
name: Meditation
def: "A state of consciousness in which the individual eliminates environmental stimuli from awareness so that the mind can focus on a single thing, producing a state of relaxation and relief from stress. A wide variety of techniques are used to clear the mind of stressful outside interferences. It includes meditation therapy. (Mosby's Medical, Nursing, and Allied Health Dictionary, 4th ed)" []
synonym: "Transcendental Meditation" EXACT []
xref: MESH:D019122
is_a: SCDO:0001284 ! Behaviour Therapy
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D019122 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000741 xsd:string

[Term]
id: SCDO:0000742
name: Mefloquine
def: "A phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects." []
synonym: "Lariam" EXACT []
synonym: "Mephloquine" EXACT []
synonym: "WR142,490" EXACT []
xref: MESH:D015767
is_a: IDOMAL:0000122 ! Malaria Chemoprophylaxis
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D015767
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000742 xsd:string

[Term]
id: SCDO:0000743
name: Membranous Nephropathy
def: "A type of glomerulonephropathy characterized by histology with thickening of the basement membrane and deposition of immune complexes in the subepithelial space." []
synonym: "Membranous Glomerulopathy" EXACT []
synonym: "MN" EXACT []
xref: HP:0012578
is_a: HP:0000112 ! Nephropathy
is_a: HP:0002715 ! Abnormality of the Immune System
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: SCDO:0000303 "Suggest update to description in HPO" xsd:string
property_value: SCDO:0000340 HP:0012578
property_value: SCDO:0000468 "Typically seen in adult population; rare in children." xsd:string
property_value: SCDO:0000661 "Idiopathic - may be related to M-type phosplipase A2 receptor antibodies; secondary forms may be related to autoimmune disease, underlying maligancies, drugs or infections. Has been reported in patients with sickle cell disease." xsd:string
property_value: SCDO:0000662 "Nephrotic syndrome with histologic features specific to membranous nephropathy." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000746
name: Mental Health
def: "Emotional, psychological, and social well-being of an individual or group." []
synonym: "Emotional Health" EXACT []
synonym: "Mental Hygiene" EXACT []
xref: MESH:D008603
is_a: NCIT:C17047 ! Quality of Life
relationship: SCDO:1000015 NCIT:C17047 ! modifies Quality of Life
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008603
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000746 xsd:string

[Term]
id: SCDO:0000747
name: Meta-Analysis
def: "Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature." []
xref: MESH:D017418
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017418 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000747 xsd:string

[Term]
id: SCDO:0000748
name: Metabolic State
def: "The state of the chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (anabolism) and the breakdown (catabolism) of organic materials utilized by the living organism." []
synonym: "Metabolic Function" EXACT []
xref: MESH:D008660
is_a: SCDO:0000122 ! Biological Disease Modifier
property_value: SCDO:0000303 "Request inclusion into relevant ontology.\n\nAdd as sub-classes: Metabolic Function Normal and Metabolic Function Abnormal? (from SNOMED CT)" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008660 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000753
name: Methemoglobinemia
def: "The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)" []
synonym: "MetHb" EXACT []
xref: MESH:D008708
is_a: OGMS:0000047 ! Genetic Disorder
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D008708 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000753 xsd:string

[Term]
id: SCDO:0000754
name: deprecated Diagnostic Method
def: "'Any procedure or test to diagnose a disease or disorder. [Curator team: []]'" []
synonym: "Diagnostic Procedure" EXACT []
xref: NCIT:C18020
is_a: SCDO:1000034 ! from diagnostics
property_value: SCDO:0000303 "Perhaps move other sibling classes below this class? (Imaging Test/Diagnostic Imaging,  --  -- Include sub-class \"Biopsy\" and include specific types below that?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C18020 xsd:string
is_obsolete: true
replaced_by: SCDO:0000082

[Term]
id: SCDO:0000760
name: Migraine Questionnaire
def: "A questionnaire to assess migraines and headaches." []
synonym: "Headache Disability Questionnaire" EXACT []
xref: phenX:130500
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Migraine\") as we have done." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX/?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F130500&jump_to_nav=true
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000762
name: Mobile Radiographic Unit
def: "Transportable radiographic equipment allowing imaging services to be brought to the patient." []
is_a: OBI:0001138 ! X-Ray Machine
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.who.int/medical_devices/innovation/hospt_equip_26.pdf xsd:string
property_value: SCDO:0000340 https://radiologykey.com/mobile-radiography/ xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000763
name: Mobility Limitation
def: "Difficulty moving from place to place or from one position to another without assistance." []
synonym: "Ambulation Difficulty" EXACT []
synonym: "Ambulatory Difficulty" EXACT []
synonym: "Difficulty Ambulation" EXACT []
synonym: "Difficulty Walking" EXACT []
synonym: "Mobility Limitations" EXACT []
xref: MESH:D051346
is_a: SCDO:0000900 ! Physical Functioning
property_value: SCDO:0000303 "Suggest update to description in MESH." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D051346 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000765
name: Genetic Phenomena
def: "The biological processes, properties, and objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits." []
synonym: "Concepts, Genetic" EXACT []
xref: MESH:D055614
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055614
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000765 xsd:string

[Term]
id: SCDO:0000766
name: obsolete Modifying the Home Environment and Making it Safer For the Patient
is_a: SCDO:1000035 ! from therapeutics
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/ADO/?p=classes&conceptid=http%3A%2F%2Fscai.fraunhofer.de%2FAlzheimerOntology%23Modifying_the_home_enviornment_and_make_it_safer_for_the_patient xsd:string
is_obsolete: true

[Term]
id: SCDO:0000771
name: Morphine
def: "The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle." []
synonym: "17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-17-ium-3,6alpha-diol" EXACT []
synonym: "Morphia" EXACT []
synonym: "Morphium" EXACT []
xref: MESH:D009020
is_a: CHEBI:35482 ! Opioid
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D009020
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000771 xsd:string

[Term]
id: SCDO:0000774
name: obsolete Multicenter Study
def: "'A work that reports on a study executed by several cooperating institutions. [Curator team: []]'" []
xref: MESH:D016448
is_a: SCDO:0000941 ! obsolete Publication Type
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016448 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000775
name: Multicenter Studies as Topic
def: "Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children." []
synonym: "Multicenter Trial" EXACT []
synonym: "Multicenter Trials" EXACT []
synonym: "Multicentre Studies as Topic" EXACT []
synonym: "Multicentre Trial" EXACT []
synonym: "Multicentre Trials" EXACT []
xref: MESH:D015337
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D015337
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000775 xsd:string

[Term]
id: SCDO:0000776
name: Multidimensional Health Locus of Control Scales (MHLC)
def: "The multidimensional health locus of control (MHLC) scale is a widely used measure of the factors that people believe exert some measures of control over their health. The MHLC originally developed by Wallston and colleagues contained 3 subscales describing various types of control-related cognitions an individual may have about the current state of his or her health. These were: Internal Health Locus of Control (IHLC), Powerful Others Health Locus of Control (PHLC) and Chance Health Locus of Control (CHLC). Subsequently, a fourth subscale, the God Locus of Health Control (G LHC) scale was developed to assess the extent of an individual's belief that God controls his or her health status was added to the measure. Thus, the expanded MHLC Consists of 4 sub-scales: one Internal and 3 external subscales namely, powerful others, chance and God. Each of the 4 sub-scales has 6 items making a total of 24 items. The two original versions of the MHLC (forms A & B) deal with the general health status whereas the third version (Form C) assesses control-related cognitions about a specific disease state." []
synonym: "MHLC" EXACT []
synonym: "MHLC Scales" EXACT []
synonym: "Multidimensional Health Locus of Control Scales" EXACT []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: http://purl.org/dc/elements/1.1/source "Wallston K., Wallston B. and De Vellis R. (1978). Development of the multidimensional health locus of control (MHLC) scales. Health Education Monographs, 6, 160-169." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Wallston KA, Malcarne VL, Flores L, Hansdottir I, Smith CA, Stein MJ, Weisman MH, Clements PJ. Does God Determine Your Health? The God Locus of Health Control Scale. Cognitive Therapy and Research . April 1999, Volume 23 (2):131-142." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Healthy population and patients with specific medical conditions" xsd:string
property_value: SCDO:0000484 "Spanish; Chinese; Persian" xsd:string
property_value: SCDO:0001033 "Has adequate construct validity and acceptable metric properties" xsd:string
property_value: SCDO:0001222 "15 years and above" xsd:string
property_value: SCDO:0001335 "no" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000777
name: Muscle Atrophy
def: "The presence of skeletal muscular atrophy, reduction in the muscle bulk." []
synonym: "Amyotrophy" EXACT []
synonym: "Muscle Wasting" EXACT []
synonym: "Muscular Atrophy" EXACT []
synonym: "Neurogenic Muscle Atrophy" EXACT []
synonym: "Skeletal Muscle Atrophy" EXACT []
xref: HP:0003202
is_a: SCDO:1000268 ! Abnormality of the Musculature
property_value: SCDO:0000303 "Suggest update to description in HPO.\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0003202 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000780
name: deprecated Musculoskeletal System
def: "Anatomical system that consists of the muscular and skeletal systems." []
synonym: "Musculo-Skeletal System" EXACT []
xref: UBERON:0002204
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/UBERON_0002204 xsd:string
is_obsolete: true
replaced_by: SCDO:0006301
replaced_by: SCDO:1000268

[Term]
id: SCDO:0000781
name: Mutation Carrier Screening
def: "The process of identifying carriers/heterozygotes of a genetic mutation that can result in a severe recessive condition. Carrier screening is done using various laboratory techniques." []
comment: This term is very similar to but different (more specific) from the term "Genetic Carrier Screening" in MESH.
synonym: "Mutation Carrier Detection" EXACT []
xref: MESH:D006580
is_a: NCIT:C92803 ! Genetic Screening
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology (MESH) or suggest inclusion of description in NCIT." xsd:string
property_value: SCDO:0000340 "Alswaidi, F.M. and O'brien, S.J., 2009. Premarital screening programmes for haemoglobinopathies, HIV and hepatitis viruses: review and factors affecting their success. Journal of medical screening, 16(1), pp.22-28." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000782
name: MYB
def: "This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants." []
synonym: "MYB Gene" EXACT []
synonym: "MYB Proto-Oncogene, Transcription Factor" EXACT []
synonym: "MYB-HSP1" EXACT []
is_a: SCDO:0000810 ! Non-Globin Gene
property_value: SCDO:0000303 "Exists in other ontologies but we have provided a description more relevant to its relationship with SCD." xsd:string
property_value: SCDO:0000303 "Link to \"Hereditary Persistence of fetal hemoglobin\"." xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/gene/4602 xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0000787
name: N-terminal Pro-brain Natriuretic Peptide Test
def: "A bioassay to determine an individual's level of N-terminal pro-brain natriuretic peptide (NT-proBNP)." []
comment: Equipment needed: Phlebotomy supplies, centrifuge for serum separation, and freezer for sample storage is required.
synonym: "NT-proBNP Test" EXACT []
xref: phenX:810501
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000194 CMO:0002876 ! measures N-Terminal Pro-Brain Natriuretic Peptide Level
property_value: SCDO:0000303 "Label different from source's \"N-terminal Pro-brain Natriuretic Peptide (NT-proBNP)\"" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810501
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000789
name: Naloxone
def: "A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors." []
synonym: "1-N-Allyl-14-hydroxynordihydromorphinone" EXACT []
synonym: "17-allyl-3,14-dihydroxy-4,5α-epoxymorphinan-6-one" EXACT []
synonym: "MRZ-2593" EXACT []
xref: MESH:D009270
is_a: CHEBI:35482 ! Opioid
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Are the synonyms included relevant to SCD? Should other synonyms from the description source be included?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D009270
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000789 xsd:string

[Term]
id: SCDO:0000791
name: Nasal Decongestants
def: "Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)" []
synonym: "Nasal Vasoconstrictor Agents" EXACT []
synonym: "Nasal Vasoconstrictors" EXACT []
xref: MESH:D014663
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001129 ! Supportive Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D014663
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000791 xsd:string

[Term]
id: SCDO:0000794
name: obsolete Nephrology
def: "'A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney. [Curator team: []]'" []
xref: MESH:D009398
is_a: SCDO:0001208 ! deprecated Urinary System
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D009398 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000796
name: Nephrotic Syndrome
def: "Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria >3.5 g per 24 hours (in children, >40 mg/m2/hr or PCR >2000 mg/g [>200 mg/mmol] or >300 mg/dl or 3+ on urine dipstick) plus hypoalbuminemia (<3gm/dl) and edema." []
synonym: "Nephrosis" EXACT []
xref: HP:0000100
is_a: HP:0000112 ! Nephropathy
relationship: SCDO:0000663 SCDO:0001205 ! diagnosed using tool Urinary Albumin Test
relationship: SCDO:0000663 SCDO:0001206 ! diagnosed using tool Urinary Creatinine Test
relationship: SCDO:0000664 SCDO:0000055 ! treated with Angiotensin-Converting Enzyme Inhibitors
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000220 SCDO:0001207 ! diagnosed using measurement Urinary Protein Measurement
relationship: SCDO:1000220 SCDO:0001210 ! diagnosed using measurement Urine Albumin Excretion Rate
relationship: SCDO:1000220 SCDO:0001212 ! diagnosed using measurement Urine Albumin-Creatinine Ratio
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Suggest update to description in the HPO" xsd:string
property_value: SCDO:0000340 HP:0000100
property_value: SCDO:0000468 "Nephrotic syndrome related to sickle cell disease typically occurs in adulthood and preceded by lesser degree of proteinuria, other forms may occur at any age with different histologic lesions occurring at different ages." xsd:string
property_value: SCDO:0000661 "Variety of causes - in sickle cell disease, most common lesion is focal segmental glomerulosclerosis (FSGS).  Other causes may be other forms of primary glomerular disease including membranous nephropathy, minimmal change disease, membranoproliferative glomerulonephritis.  Secondary forms may result from diabetes, amyloidosis." xsd:string
property_value: SCDO:0000662 "Heavy proteinuria, edema, hyperlipidemia. May also be associated with hypertension and increased risk of venous thrombosis." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000797
name: Nephrotic Range Proteinuria
def: "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children." []
comment: Is diagnosed by assessment of proteinuria (see Proteinuria) by 24hr urine collection or by urine protein-creatinine ratio on spot urine sample [KDIGO 2012].
synonym: "Nephrotic-Range Proteinuria" EXACT []
xref: HP:0012593
is_a: SCDO:0000932 ! Proteinuria
relationship: SCDO:0000663 SCDO:0001205 ! diagnosed using tool Urinary Albumin Test
relationship: SCDO:0000663 SCDO:0001206 ! diagnosed using tool Urinary Creatinine Test
relationship: SCDO:0000664 SCDO:0000055 ! treated with Angiotensin-Converting Enzyme Inhibitors
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000220 SCDO:0001207 ! diagnosed using measurement Urinary Protein Measurement
relationship: SCDO:1000220 SCDO:0001210 ! diagnosed using measurement Urine Albumin Excretion Rate
relationship: SCDO:1000220 SCDO:0001212 ! diagnosed using measurement Urine Albumin-Creatinine Ratio
property_value: http://purl.org/dc/elements/1.1/source HP:0012593
property_value: http://purl.org/dc/elements/1.1/source http://www.kdigo.org/clinical_practice_guidelines/pdf/KDIGO-GN-Guideline.pdf
property_value: SCDO:0000303 "Suggest update to description in HPO." xsd:string
property_value: SCDO:0000340 HP:0012593
property_value: SCDO:0000340 http://www.kdigo.org/clinical_practice_guidelines/pdf/KDIGO-GN-Guideline.pdf
property_value: SCDO:0000468 "In sickle cell disease, seen primarily in adult population but may develop in childhood if secondary cause occurs." xsd:string
property_value: SCDO:0000661 "Glomerular diseases that lead to protein loss in the urine (See Nephrotic Syndrome)." xsd:string
property_value: SCDO:0000662 "Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000798
name: deprecated Nervous System
def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior." []
synonym: "Neurological System" EXACT []
xref: UBERON:0001016
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/UBERON_0001016 xsd:string
is_obsolete: true
replaced_by: SCDO:0009698

[Term]
id: SCDO:0000799
name: Neurocognitive Impairment
def: "An invisible complication of sickle cell anemia (SSA) that defies detection by imaging and other routine diagnostic methods. Impaired neurocognitive function in seemingly neurologically intact patients is not related to vasoocclusion or hemolysis. It is detected by neuropsychiatric and neurobehavioral testing and is associated with anemia and age." []
is_a: HP:0012638 ! Abnormal Nervous System Physiology
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415156/ xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000801
name: Neurological Rehabilitation
def: "Physician-supervised programs designed to rehabilitate people with diseases, trauma, or disorders of the nervous system." []
synonym: "Neurologic Rehabilitation" EXACT []
synonym: "Neurorehabilitation" EXACT []
synonym: "Rehabilitation, Neurologic" EXACT []
synonym: "Rehabilitation, Neurological" EXACT []
xref: MESH:D000066530
is_a: SCDO:0000978 ! Rehabilitation
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000066530 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000801 xsd:string

[Term]
id: SCDO:0000803
name: Neonatal Screening for Sickle Cell
def: "Testing of neonates to identify those with major sickling diseases." []
synonym: "Newborn Infant Screening for Sickle Cell" EXACT []
is_a: SCDO:0001049 ! Sickle Cell Disease Screening Test
property_value: SCDO:0000303 "Link to \"Hb isoelectric focusing\" and \"HPLC fractionation\" ?\n\nRequest inclusion into relevant ontology. Perhaps in SNOMED CT below \"Screening for sickle cell disease\"?" xsd:string
property_value: SCDO:0000340 "Newborn Screening for Sickle Cell Disease and Other Hemoglobinopathies. JAMA. 1987;258(9):1205–1209. doi:10.1001/jama.1987.03400090089040" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000804
name: NIH Stroke Scale (NIHSS)
def: "A physical assessment of the various symptoms associated with a stroke, consisting of 11 categories. For each category, the test administrator asks the respondent to perform an activity or respond to stimuli. Respondents receive a score for each category based upon their ability to complete the activity or respond to the action. Each score typically ranges from 0 to 3. Each category of the NIHSS is designed to determine the respondent's level of consciousness (LOC), visual, motor, or language ability." []
synonym: "NIH Stroke Scale" EXACT []
synonym: "NIHSS" EXACT []
xref: phenX:820801
is_a: SCDO:0001112 ! Stroke Impact Measure
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820801 xsd:string
property_value: SCDO:0000479 "PhenX protocol: NIH Stroke Scale (NIHSS) #820801" xsd:string
property_value: SCDO:0001222 "18 years and older" xsd:string
property_value: SCDO:0001335 "Examiners must be trained to administer, score, and interpret the NIH Stroke Scale (NIHSS). The National Institute of Neurological Disorders and Stroke (NINDS) provides a comprehensive interactive training DVD for the NIHSS. Information and purchasing details for this training are available on the NINDS website." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000807
name: No-Show Patient
def: "Patients who do not turn up for scheduled healthcare appointments." []
synonym: "No Show Patient" EXACT []
synonym: "Patient No Show" EXACT []
synonym: "Patient No-Show" EXACT []
xref: MESH:D000067455
is_a: SCDO:0000869 ! Patient Compliance
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000067455 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000807 xsd:string

[Term]
id: SCDO:0000808
name: Nocturia
def: "Frequent urination at night that interrupts sleep. It is often associated with outflow obstruction, diabetes mellitus, or bladder inflammation (cystitis)." []
comment: Often occuring as a result of heart insufficiency.
synonym: "Nycturia" EXACT []
xref: MESH:D053158
is_a: HP:0000079 ! Abnormality of the Urinary System
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D053158 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000808 xsd:string

[Term]
id: SCDO:0000809
name: Non Opioid
def: "A subclass of analgesic agents that typically do not bind to opioid receptors and are not addictive. Many non-narcotic analgesics are offered as nonprescription drugs." []
synonym: "Non-Narcotic" EXACT []
synonym: "Nonnarcotic" EXACT []
synonym: "Nonnarcotic Analgesic" EXACT []
synonym: "Nonnarcotic Opioid" EXACT []
synonym: "Nonopioid" EXACT []
xref: MESH:D018712
is_a: SCDO:0000050 ! Analgesic
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018712 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000809 xsd:string

[Term]
id: SCDO:0000810
name: Non-Globin Gene
def: "A gene that does not encode a globin family protein." []
is_a: NCIT:C16612 ! Gene
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Perhaps too specific to the SCDO to be included in other ontologies?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000811
name: Non-Proliferative Sickle Retinopathy
def: "Sickle retinopathy caused by direct damage or remodeling of the small blood vessels supplying the retina secondary to vaso-occlusion and local ischemia." []
is_a: SCDO:0001067 ! Sickle Retinopathy
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into HPO below \"Retinopathy/Sickle Retinopathy\"." xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Retinopathy xsd:string
property_value: SCDO:0000340 http://eyewiki.aao.org/Sickle_Cell_Retinopathy xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000812
name: Non-specific Acute Lower Respiratory Tract Episode
def: "Includes acute respiratory episodes with lower respiratory tract signs that do not meet the criteria for other diagnoses. May include episodes which would have been diagnosed as ACS were radiographic facilities available." []
is_a: HP:0002086 ! Abnormality of the Respiratory System
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000576 ! treated with Hydration Therapy
relationship: SCDO:0000664 SCDO:0000903 ! treated with Physiotherapy
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000661 "Several possible etiologies including infections by various classes of microorganisms, pulmonary fat emobolism, infarction and pulmonary embolism." xsd:string
property_value: SCDO:0000662 "Acute onset of respiratory symptoms and signs including cough, coryza +/- fever." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000818
name: obsolete Observational Study
def: "'A work that reports on the results of a clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study). [Curator team: []]'" []
xref: MESH:D064888
is_a: SCDO:0000252 ! obsolete Clinical Study
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D064888 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000819
name: Observational Studies as Topic
def: "Works about clinical studies in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study)." []
xref: MESH:D064887
is_a: SCDO:0000253 ! Clinical Studies as Topic
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D064887 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000819 xsd:string

[Term]
id: SCDO:0000822
name: Occupational Therapy
def: "Skilled treatment that helps individuals achieve independence in all facets of their lives. It assists in the development of skills needed for independent living." []
synonym: "Occupational Therapies" EXACT []
synonym: "Therapies, Occupational" EXACT []
synonym: "Therapy, Occupational" EXACT []
xref: MESH:D009788
is_a: SCDO:0000978 ! Rehabilitation
relationship: SCDO:1000018 DOID:1188 ! treats Mononeuropathy
relationship: SCDO:1000018 HP:0001271 ! treats Polyneuropathy
relationship: SCDO:1000018 HP:0001342 ! treats Cerebral Hemorrhage
relationship: SCDO:1000018 HP:0001370 ! treats Rheumatoid Arthritis
relationship: SCDO:1000018 HP:0010628 ! treats Facial Nerve Palsy
relationship: SCDO:1000018 NCIT:C26702 ! treats Ataxia
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D009788 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000822 xsd:string

[Term]
id: SCDO:0000828
name: Oliguria
def: "Low output of urine, defined as an output below 5mL/kg/hr over 6 hours." []
synonym: "Reduced Urine Output" EXACT []
xref: HP:0100520
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000220 CMO:0000256 ! diagnosed using measurement Urine Measurement
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Suggest update to description in HPO" xsd:string
property_value: SCDO:0000340 HP:0100520
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000833
name: Ophthalmologic Surgical Procedure
def: "Surgery performed on the eye or any of its parts." []
synonym: "Ophthalmologic Surgical Procedures" EXACT []
synonym: "Ophthalmological Surgical Procedure" EXACT []
xref: MESH:D013508
is_a: SCDO:0001133 ! Symptomatic Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D013508 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000833 xsd:string

[Term]
id: SCDO:0000834
name: Ophthalmoscope
def: "Device for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth." []
synonym: "Funduscope" EXACT []
synonym: "Ophthalmoscopes" EXACT []
xref: MESH:D019721
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 NCIT:C101217 ! used by diagnostic tool Retinal Examination
relationship: SCDO:1000191 SCDO:0000835 ! used by diagnostic tool Ophthalmoscopy
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D019721 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000834 xsd:string

[Term]
id: SCDO:0000835
name: Ophthalmoscopy
def: "Examination of the interior of the eye with an ophthalmoscope." []
xref: MESH:D009887
is_a: NCIT:C38060 ! Eye Examination
relationship: SCDO:1000192 SCDO:0000834 ! uses diagnostic device Ophthalmoscope
property_value: SCDO:0000303 "Include \"Direct Ophthalmoscopy\" and \"Indirect Ophthalmoscopy\" from NCIT as sub-classes? (Direct could be used to diagnose \"Conjunctival Comma Sign\")" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D009887 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000835 xsd:string

[Term]
id: SCDO:0000839
name: Osteomalacia
def: "A general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets." []
synonym: "Adult Rickets" EXACT []
xref: HP:0002749
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Suggest update to description in HPO. (remove \"Osteomalacia\" from start of definitiion)\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002749 xsd:string
property_value: SCDO:0000661 "Abnormal vitamin D metabolism: 1) Deficient intake or absorption;2) Defective 25-hydroxylation due to biliary cirrhosis- alcoholic cirrhosis- anticonvulsants; 3)  Loss of vitamin D binding protein- nephrotic syndrome; 4) Defective 1-alpha 25-hydroxylation: Hypoparathyroidism, Renal failure, Vitamin D-dependent rickets type 1; 5)  Defective target organ response to calcitriol: Vitamin D-dependent rickets, type II (Hereditary vitamin D resistant rickets, HVDRR).  Mineralization defects: 1) Abnormal matrix: Chronic renal failure, Osteogenesis imperfecta, Fibrogenesis imperfecta, Axial osteomalacia; 2) Enzyme deficiency: Hypophosphatasia; 3) Mineralization inhibitors: bisphosphonates, Aluminum, fluoride. Phosphate deficiency: 1) Decreased intake ( antiacids);  2) Impaired renal reabsorption, that can be Primary defects = X-linked hypophosphatemic rickets (vitamin D resistant rickets, VDRR), Hereditary hypophosphatemic rickets with hypercalciuria, Sporadic acquired hypophosphatemic rickets, Fanconi syndrome, Wilson disease, cystinosis, multiple myeloma; or can be Secondary defects = 2) Secondary hyperparathyroidism (renal tubular acidosis, type 1 and disorders of vitamin D metabolism), 2) Oncogenic osteomalacia." xsd:string
property_value: SCDO:0000662 "May be asymptomatic and present radiologically as osteopenia. Or it may present as diffuse bone and joint pain, muscle weakness, and difficulty walking, Fractures, Muscle spasms, cramps." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000840
name: Osteomyelitis
def: "An inflammatory process accompanied by bone destruction and caused by an infecting microorganism." []
comment: Osteomyelitis can be acute or chronic and can be caused by a variety of microbial agents.
synonym: "Bone Infection" EXACT []
xref: HP:0002754
is_a: HP:0000924 ! Abnormality of the Skeletal System
is_a: IDO:0000586 ! Infection
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Suggest update to description in HPO (remove \"Osteomyelitis is\" from the start of the definition.\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0002754 xsd:string
property_value: SCDO:0000661 "Bacteria, blunt trauma, fracture, bone surgery." xsd:string
property_value: SCDO:0000662 "Tenderness, redness, and warmth in the area of infection, fever, fatigue, bone pain, swelling around the affected bone, lost range of motion." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000849
name: Arterial Oxygen Saturation
def: "The amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity, as determined by an arterial blood gas test." []
synonym: "Arterial HbO2" EXACT []
synonym: "Arterial Oxyhemoglobin Saturation" EXACT []
synonym: "Arterial SaO2" EXACT []
synonym: "Arterial Sats" EXACT []
synonym: "HBOXHGB" EXACT []
synonym: "Oxygen Saturation of Arterial Blood" EXACT []
synonym: "Oxyhemoglobin to Total Hemoglobin Ratio Measurement" EXACT []
synonym: "Oxyhemoglobin/Total Hemoglobin" EXACT []
is_a: CMO:0000225 ! Arterial Blood Gas Measurement
is_a: CMO:0001324 ! Oxygen Saturation
relationship: SCDO:1000190 SCDO:0000071 ! obtained via diagnostic tool Arterial Blood Gas Test
relationship: SCDO:1000772 SCDO:1000808 ! has possible finding Decreased Arterial Oxygen Saturation
relationship: SCDO:1000772 SCDO:1000813 ! has possible finding Normal Arterial Oxygen Saturation
property_value: SCDO:0000303 "Request inclusion into CMO below \"Oxygen Saturation\"" xsd:string
property_value: SCDO:0000340 CMO:0001324
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000851
name: Pain
def: "An unpleasant sensory and emotional experience triggered in the nervous system, associated with actual or potential tissue damage, or described in terms of such damage." []
xref: HP:0012531
is_a: HP:0025142 ! Constitutional Symptom
relationship: SCDO:0000664 SCDO:0001167 ! treated with Transcutaneous Electrical Nerve Stimulation
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Suggest update to description in HPO.\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0012531 xsd:string
property_value: SCDO:0000661 "Somatic pain is caused by injury to skin, muscles, bone, joint, and connective tissues. Deep somatic pain is usually described as dull or aching, and localized in one area. Visceral pain refers to pain that originates from ongoing injury to the internal organs or the tissues that support them. Somatic pain from injury to the skin or the tissues just below it often is sharper and may have a burning or pricking quality." xsd:string
property_value: SCDO:0000662 "Nociceptive pain is believed to be caused by the ongoing activation of pain receptors in either the surface or deep tissues of the body. There are two types: \"somatic\" pain and \"visceral\" pain.  Neuropathic pain is believed to be caused by changes in the nervous system that sustain pain even after an injury heals. \"Psychogenic\" pain is a simple label for all kinds of pain that can be best explained by psychological problems." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000852
name: Pain Status
def: "The impact of sickle cell pain on the daily activities of patients. The degree to which pain interferes with their quality of life. This pain is related to the unique features of Sickle Cell Disease." []
synonym: "Pain Burden" EXACT []
synonym: "Pain Disability" EXACT []
synonym: "Pain Impact" EXACT []
synonym: "Pain Interference" EXACT []
is_a: SCDO:0000900 ! Physical Functioning
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000864
name: Palpation of Liver
def: "A method of determining the shape and consistency of the liver by feeling with the fingers or hands." []
synonym: "Liver Palpation" EXACT []
is_a: SCDO:0000694 ! Liver Examination
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000866
name: Parasite
def: "Invertebrate organisms that live on or in another organism (the host), and benefit at the expense of the other. Traditionally excluded from definition of parasites are pathogenic bacteria; fungi; viruses; and plants; though they may live parasitically." []
synonym: "Parasites" EXACT []
xref: MESH:D010271
is_a: OBI:0000925 ! Infectious Agent
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D010271 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000866 xsd:string

[Term]
id: SCDO:0000869
name: Patient Compliance
def: "Voluntary cooperation of the patient in following a prescribed regimen." []
synonym: "Adherence" EXACT []
synonym: "Patient Adherence" EXACT []
synonym: "Patient Cooperation" EXACT []
xref: MESH:D010349
is_a: SCDO:0000487 ! Health Behaviour
is_a: SCDO:0000746 ! Mental Health
relationship: SCDO:1000015 NCIT:C39547 ! modifies Treatment Efficacy
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D010349 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000869 xsd:string

[Term]
id: SCDO:0000873
name: Pediatric Migraine Disability Assessment
def: "A headache disability questionnaire which is completed by the patient and his/her parent and is reviewed with the clinician or study staff. It captures the impact of headaches on school performance (three questions), activities at home (one question on homework or chores), and social and/or sports functions (two questions). It is scored by summing the answers across the six questions. If a range is provided as an answer, either use the high end of the range or prompt for a single answer. The frequency and severity are not scored but can be used for clinical reference." []
synonym: "Pediatric Migraine Questionnaire" EXACT []
synonym: "PedMIDAS" EXACT []
xref: phenX:130502
is_a: SCDO:0000760 ! Migraine Questionnaire
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Migraine - Children\") as we have done." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/130502
property_value: SCDO:0000479 "PhenX protocol: Migraine - Children #130502" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000874
name: Pediatric NIH Stroke Scale (PedNIHSS)
def: "A physical assessment of the various symptoms associated with a stroke, consisting of eleven categories. The PedNIHSS was developed by a panel of pediatric and adult stroke experts and is a modification of the adult NIH stroke scale (NIHSS). Modifications were made to allow individuals age 18 or younger to be assessed and are identified in the PedNIHSS by bold italic text." []
comment: For each category of the PedNIHSS, the examiner asks the respondent to perform an activity or respond to an action by the provider. Respondents receive a score for each category based upon their ability to complete the activity or respond to the action. Each score typically ranges from 0 to 3. Each category of the PedNIHSS is designed to determine the respondent’s level of consciousness (LOC), visual, motor, or language ability.
synonym: "Pediatric NIH Stroke Scale" EXACT []
synonym: "PedNIHSS" EXACT []
xref: phenX:820802
is_a: SCDO:0001112 ! Stroke Impact Measure
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820802 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Pediatric NIH Stroke Scale (PedNIHSS) #820802" xsd:string
property_value: SCDO:0001222 "2-18 years old" xsd:string
property_value: SCDO:0001335 "Examiners must be trained to administer, score, and interpret the NIHSS. The National Institute of Neurological Disorders and Stroke (NINDS) provides a comprehensive interactive training DVD for the National Institutes of Health Stroke Scale (NIHSS). Information and purchasing details for this training is available on the NINDS website." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000876
name: Pediatric School Performance Measure
def: "A questionnaire to assess educational performance and learning accommodations." []
xref: phenX:840200
is_a: SCDO:0000951 ! Quality of Life and Care Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/840201
property_value: SCDO:0000303 "Suggest update to label in PhenX as we have done." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F840200
property_value: SCDO:0000479 "PhenX protocol: Pediatric School Performance #840201" xsd:string
property_value: SCDO:0000486 "Many rare genetic conditions (e.g., sickle cell disease) and other diseases are associated with developmental delays, damage to the central nervous system, and frequent absences from school due to illness, all of which can impact school performance." xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000877
name: PedsQL Multidimensional Fatigue Scale
def: "A generic symptom-specific instrument to measure fatigue across pediatric populations." []
comment: The 18-item PedsQL Multidimensional Fatigue Scale encompasses three domains: 1) General Fatigue, 2) Sleep/Rest Fatigue and 3) Cognitive Fatigue. The format, instructions, Likert response scale, and scoring method are identical to the PedsQL 4.0 Generic Core Scales [16], with higher scores indicating better HRQOL (lower fatigue symptoms). The instructions ask how much of a problem each item has been during the past one month.
is_a: NCIT:C78652 ! Pediatric Quality of Life Inventory (PedsQL)
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Pediatric Quality of Life Inventory\"." xsd:string
property_value: SCDO:0000340 "Panepinto JA, Torres S, Bendo CB, McCavit TL, Dinu B, Sherman-Bien S, Bemrich-Stolz C, Varni JW (2014). PedsQL Multidimensional Fatigue Scale in sickle cell disease: feasibility, reliability, and validity. Pediatric Blood & Cancer, 61,171-177" xsd:string
property_value: SCDO:0000481 "Self; Proxy (Parent report)" xsd:string
property_value: SCDO:0000482 "Clinic patients" xsd:string
property_value: SCDO:0001033 "Validation study in SCD" xsd:string
property_value: SCDO:0001222 "Children 2 - 18 (child report ages 5 - 18 years; parent proxy report of children ages 2 - 18 years)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000878
name: PedsQL Sickle Cell Disease Module
def: "The PedsQL Sickle Cell Disease Module includes 43 items from 9 subscales: Pain and Hurt (9 items); Pain Impact (10 items); Pain Management and Control (2 items); Worry (5 items); Worry II (2 items); Emotions (2 items); Treatment (7 items); Communication I (3 items); and Communication II (3 items). For all ages, each item asks how much of a problem there has been in the past month. There are self- or parent-reported forms for ages 8 to 18, and responses are scored on a 5-point Likert-style scale (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). Forms for children ages 5 to 7 are interviewer-administered, and responses include a 3-point Likert-style scale (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reversed-scored and converted to a 100-point scale (0 = 100, 1 = 75, 2 = 50, 3 = 25, 4 = 0) with higher scores indicating better quality of life. Scores for individual subscales are the sum of items divided by the total number or items answered. The total score for the PedsQL Sickle Cell Disease Module is the sum of the items divided by the number of items answered." []
is_a: NCIT:C78652 ! Pediatric Quality of Life Inventory (PedsQL)
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: http://purl.org/dc/elements/1.1/source "Panepinto JA, Torres S, Bendo CB, McCavit TL, Dinu B, Sherman-Bien S, Bemrich-Stolz C, Varni JW (2013).PedsQL sickle cell disease module: feasibility, reliability, and validity.Pediatric Blood & Cancer, 60,1338-1344." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Pediatric Quality of Life Inventory\"." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/820202
property_value: SCDO:0000479 "PhenX protocol: PedsQL Sickle Cell Disease Module #820202" xsd:string
property_value: SCDO:0000481 "Self; Proxy (Parent report)" xsd:string
property_value: SCDO:0000482 "Clinic Patients (Children with SCD)" xsd:string
property_value: SCDO:0001222 "Ages 2 to 18" xsd:string
property_value: SCDO:0001335 "No. The PedsQ Sickle Cell Disease Module is a proprietary instrument and administration requires permission and a license from the MAPI Research Trust." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000881
name: Penicillin Prophylaxis
def: "Use of penicillin for the prevention of infections with penicillin-susceptible organisms, e.g. Streptococcus pneumoniae." []
is_a: NCIT:C51993 ! Antibiotic Prophylaxis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000882
name: Percussion of Liver
def: "A method of determining the size of the liver by tapping on the surface of the abdomen." []
is_a: SCDO:0000694 ! Liver Examination
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "To be requested for inclusion into SNOMED CT, below \"Diagnostic procedure on liver\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000885
name: Peripheral Oxygen Saturation
def: "An estimation of the oxygen saturation level usually measured with a pulse oximeter device." []
synonym: "Oxygen Saturation of Peripheral Blood" EXACT []
synonym: "Peripheral  SaO2" EXACT []
synonym: "Peripheral  Sats" EXACT []
synonym: "Peripheral HbO2" EXACT []
synonym: "Peripheral Oxyhemoglobin Saturation" EXACT []
synonym: "SpO2" EXACT []
xref: SNOMEDCT:431314004
is_a: CMO:0001324 ! Oxygen Saturation
relationship: SCDO:1000190 SCDO:0000945 ! obtained via diagnostic tool Pulse Oximetry (Rest)
relationship: SCDO:1000193 SCDO:0000944 ! output of diagnostic device Pulse Oximeter
property_value: SCDO:0000303 "Request inclusion into CMO below \"Oxygen Saturation\"" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Oxygen_saturation_(medicine) xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000895
name: Phenotype of Sickle Cell Disease
def: "A (combination of) quality(ies) of some or all sickle cell disease individuals, determined by the interaction of the genetic make-up of these individuals (with regard to sickle cell disease) and their environment." []
xref: OGMS:0000023
is_a: HP:0000118 ! Abnormal Phenotype
is_a: OGMS:0000028 ! Disease Phenotype
relationship: SCDO:1000005 HP:0011904 ! modified by Increased Hemoglobin F
relationship: SCDO:1000005 SCDO:0000042 ! modified by Alpha Thalassemia
relationship: SCDO:1000005 SCDO:0000580 ! modified by Hydroxyurea
relationship: SCDO:1000005 SCDO:0001386 ! modified by Alpha-Globin Locus Deletion
relationship: SCDO:1000005 SCDO:0008713 ! modified by Sickle Cell Anemia Associated with Alpha Thalassemia
relationship: SCDO:1000005 SCDO:1000060 ! modified by SCD Molecular Phenotype
relationship: SCDO:1000005 SCDO:1000061 ! modified by Altered Level of Normal Hemoglobin in SCD
relationship: SCDO:1000005 SCDO:1000707 ! modified by Hemoglobin F Level
relationship: SCDO:1000015 SCDO:0000952 ! modifies Quality of Life in Sickle Cell Disease Measure
relationship: SCDO:1000202 SCDO:1000060 ! caused by SCD Molecular Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Probably too specific to warrant inclusion into anther ontology.\n\nMake sure complications as described in \"Definitions of the Phenotypic Manifestations of Sickle Cell Disease\" (Ballas, 2010) are included in Phenotype." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/OGMS?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FOGMS_0000023 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000896
name: Physical Detection Method
def: "The physical method (technology) used to measure / readout the effect caused by a perturbagen in the assay environment." []
xref: BAO:0000035
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000340 BAO?p=classes&conceptid=http%3A%2F%2Fwww.bioassayontology.org%2Fbao%23BAO:0000035
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000896 xsd:string

[Term]
id: SCDO:0000897
name: Physical Environment
def: "The part of the human environment that consists of purely physical factors, including the natural environment (such as soil, climate, water supply) and the built environment." []
is_a: SCDO:0000435 ! Environmental Disease Modifier
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Physical Environment. Merriam-Webster.com. Merriam-Webster, n.d. Web. 9 Nov. 2016." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000898
name: Physical Examination
def: "Systematic and thorough inspection of the patient for physical signs of disease or abnormality." []
synonym: "Physical Assessment" EXACT []
xref: MESH:D010808
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D010808 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000898 xsd:string

[Term]
id: SCDO:0000900
name: Physical Functioning
def: "One's ability to carry out activities that require physical actions, ranging from self-care (activities of daily living) to more complex activities that require a combination of skills, often within a social context. Physical function is inclusive of the term disability and includes the full spectrum of physical functioning from severe impairment to exceptional physical abilities." []
synonym: "Mobility" EXACT []
synonym: "Motor Function" EXACT []
synonym: "Physical Function" EXACT []
synonym: "Physical Health" EXACT []
is_a: NCIT:C17047 ! Quality of Life
relationship: SCDO:1000015 NCIT:C17047 ! modifies Quality of Life
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Determine and specify the description source. --  -- Include a term to do with level of independence?" xsd:string
property_value: SCDO:0000340 https://www.gem-measures.org/Public/MeasureDetail.aspx?mid=2177&cat=2
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000902
name: Physiological Assay
def: "An organismal assay designed to capture information pertaining to the organic processes and phenomena of an organism or any of its parts or of a particular bodily process." []
xref: ERO:0001292
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0001292 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000902 xsd:string

[Term]
id: SCDO:0000903
name: Physiotherapy
def: "A therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention." []
synonym: "Physical Therapy" EXACT []
xref: OAE:0002476
is_a: SCDO:0000978 ! Rehabilitation
relationship: SCDO:1000018 DOID:1188 ! treats Mononeuropathy
relationship: SCDO:1000018 DOID:1584 ! treats Acute Chest Syndrome
relationship: SCDO:1000018 HP:0001271 ! treats Polyneuropathy
relationship: SCDO:1000018 HP:0001342 ! treats Cerebral Hemorrhage
relationship: SCDO:1000018 HP:0001369 ! treats Arthritis
relationship: SCDO:1000018 HP:0001370 ! treats Rheumatoid Arthritis
relationship: SCDO:1000018 HP:0002341 ! treats Cervical Cord Compression
relationship: SCDO:1000018 HP:0002650 ! treats Scoliosis
relationship: SCDO:1000018 HP:0003302 ! treats Spondylolisthesis
relationship: SCDO:1000018 HP:0010628 ! treats Facial Nerve Palsy
relationship: SCDO:1000018 HP:0011868 ! treats Sciatica
relationship: SCDO:1000018 HP:0100774 ! treats Hyperostosis
relationship: SCDO:1000018 NCIT:C26702 ! treats Ataxia
relationship: SCDO:1000018 SCDO:0000032 ! treats Agenesis of Corpus Callosum
relationship: SCDO:1000018 SCDO:0000812 ! treats Non-specific Acute Lower Respiratory Tract Episode
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OAE_0002476 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000903 xsd:string

[Term]
id: SCDO:0000905
name: Pilot Projects
def: "Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work." []
synonym: "Pilot Study" EXACT []
xref: MESH:D010865
is_a: SCDO:0300004 ! Epidemiologic Study Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D010865 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000905 xsd:string

[Term]
id: SCDO:0000908
name: Pneumatic Retinopexy
def: "A nonincisional procedure that has become a well-accepted alternative to scleral buckling and vitrectomy for the repair of selected cases of rhegmatogenous retinal detachment." []
is_a: SCDO:0000833 ! Ophthalmologic Surgical Procedure
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://emedicine.medscape.com/article/1844217-overview xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000913
name: Polymerase Chain Reaction
def: "The process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As the process progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified." []
synonym: "PCR" EXACT []
xref: OBI:0000415
is_a: SCDO:0000448 ! Genetic Technique
property_value: SCDO:0000303 "Suggest update to description in OBI" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/OBI_0000415 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000917
name: Pragmatic Clinical Trial
def: "'Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts. [Curator team: []]'" []
xref: MESH:D065007
is_a: SCDO:0000965 ! obsolete Randomized Controlled Trial
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D065007 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000919
name: Prenatal Screening for Sickle Cell
def: "Prenatal detection of a fetus affected with Sickle Cell Disease using appropriate laboratory techniques. Detection of affected fetuses allows couples to make informed decisions regarding the pregnancy." []
is_a: SCDO:0001049 ! Sickle Cell Disease Screening Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Perhaps in SNOMED CT below \"Screening for sickle cell disease\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000922
name: Preventative Therapeutics
def: "Activities to prevent Sickle Cell Disease or its complications." []
synonym: "Preventive Therapeutics" EXACT []
synonym: "Prophylactic Therapeutics" EXACT []
is_a: SCDO:0001152 ! Therapeutics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Probably too specific to SCD to be included in other ontologies.\n\nConsider making the description more generic (e.g. \"Activities to prevent a disease or its complications.\")" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000923
name: Priapism
def: "A prolonged painful erection that may last hours and is not associated with sexual activity. It is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma, and certain drug treatments." []
xref: MESH:D011317
is_a: HP:0000080 ! Abnormality of Reproductive System Physiology
is_a: SCDO:0000016 ! Acute Complications of Sickle Cell Disease
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011317 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000923 xsd:string

[Term]
id: SCDO:0000924
name: Primary Healthcare
def: "Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community." []
synonym: "Primary Care" EXACT []
synonym: "Primary Health Care" EXACT []
xref: MESH:D011320
is_a: SCDO:0000494 ! Health System
property_value: SCDO:0000303 "This term is not below Quality of Health Care in MESH, but below \"Health Services Administration\" ---> \"Patient Care Management\" ---> \"Comprehensive Health Care" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011320 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000924 xsd:string

[Term]
id: SCDO:0000925
name: Proguanil
def: "A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. Cycloguanil stops the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite." []
synonym: "1-(P-Chlorophenyl)-5-isopropylbiguanide" EXACT []
synonym: "Chlorguanid" EXACT []
synonym: "Chlorguanide" EXACT []
synonym: "Chloroguanide" EXACT []
synonym: "N-(4-Chlorophenyl)-n'-(isopropyl)-imidodicarbonimidic diamide" EXACT []
xref: MESH:D002727
is_a: IDOMAL:0000122 ! Malaria Chemoprophylaxis
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000303 "Suggest update to description in MESH" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D002727
property_value: SCDO:0000340 https://www.drugbank.ca/drugs/DB01131
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000926
name: Proliferative Sickle Retinopathy
def: "Sickle retinopathy that involves the upregulation of vascular growth factors due to chronic changes of local hypoxia and ischemia." []
synonym: "Retinopathy due to SCD Characterized by Neovascularization" EXACT []
synonym: "Sickle Cell Proliferative Retinopathy" EXACT []
is_a: SCDO:0001067 ! Sickle Retinopathy
relationship: SCDO:0000663 NCIT:C101217 ! diagnosed using tool Retinal Examination
relationship: SCDO:0000663 NCIT:C75583 ! diagnosed using tool Slit-Lamp Examination
relationship: SCDO:0000663 SCDO:0001327 ! diagnosed using tool Fluorescein Angiography
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into HPO below \"Retinopathy/Sickle Retinopathy\"." xsd:string
property_value: SCDO:0000340 http://eyewiki.aao.org/Sickle_Cell_Retinopathy xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000927
name: PROMIS Adult Profile 29
def: "This protocol includes 29 self-administered quality of life-type questions from the PROMIS Profile 29 for adults. The quality of life questions include physical function, anxiety, depression, fatigue, sleep disturbance, ability to participate in social roles and activities, and pain intensity over the past 7 days. Each question, except for the pain intensity question, is measured on a 5-point scale." []
synonym: "PROMIS 25 Profie v2.0" EXACT []
is_a: NCIT:C102988 ! Patient Reported Outcomes Measurement Information System (PROMIS)
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to label in PhenX as we have done." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=221302 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Quality of Life - Adult #221302" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000928
name: PROMIS Pediatric Profile 25
def: "This protocol includes 25 quality of life-type questions relating to physical function mobility, anxiety, depressive symptoms, fatigue, peer relationships, pain interference, and pain intensity over the past 7 days." []
synonym: "PROMIS 25" EXACT []
synonym: "PROMIS 25 Profie" EXACT []
is_a: NCIT:C102988 ! Patient Reported Outcomes Measurement Information System (PROMIS)
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to label in PhenX as we have done." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=221301 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Quality of Life - Pediatric #221301" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000930
name: Infection Prophylaxis
def: "A planned process that has the objective to reduce the risk of acquiring one or more infections." []
synonym: "Disease Prevention" EXACT []
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0000922 ! Preventative Therapeutics
relationship: SCDO:1000018 MP:0002412 ! treats Increased Susceptibility to Bacterial Infection
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/source http://purl.obolibrary.org/obo/OGMS_0000103 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0000931
name: Prospective Studies
def: "Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group." []
synonym: "Prospective Study" EXACT []
xref: MESH:D011446
is_a: SCDO:0000263 ! Cohort Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011446 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000931 xsd:string

[Term]
id: SCDO:0000932
name: Proteinuria
def: "Increased amounts of any protein (including albumin) in the urine - typically more than 300mg in a 24hr period." []
comment: Screening Recommendations: Screen all individuals with SCD, beginning by age 10, for proteinuria.  If the result is negative, repeat screening annually.  If the result is positive, perform a first morning void urine albumin-creatinine ratio and if abnormal, consult with or refer to a renal specialist.
synonym: "High Urine Protein Levels" EXACT []
xref: HP:0000093
is_a: HP:0003110 ! Abnormal Urine Homeostasis
relationship: SCDO:0000664 SCDO:0000055 ! treated with Angiotensin-Converting Enzyme Inhibitors
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000220 CMO:0000057 ! diagnosed using measurement Serum Creatinine Level
relationship: SCDO:1000220 SCDO:0001207 ! diagnosed using measurement Urinary Protein Measurement
relationship: SCDO:1000220 SCDO:0001209 ! diagnosed using measurement Urine Albumin Concentration
relationship: SCDO:1000220 SCDO:0001210 ! diagnosed using measurement Urine Albumin Excretion Rate
relationship: SCDO:1000220 SCDO:0001212 ! diagnosed using measurement Urine Albumin-Creatinine Ratio
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: http://purl.org/dc/elements/1.1/source http://www.nhlbi.nih.gov/health-pro/guidelines/sickle-cell-disease-guidelines
property_value: SCDO:0000303 "Suggest update to description in HPO." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0000093 xsd:string
property_value: SCDO:0000468 "In sickle cell disease, overt proteinuria (distinguised from albuminuria) may be noted in childhood although less common (4.5% in ages 2-21 [Wigfall 2000] v. 26% in adults [Guasch 2006])." xsd:string
property_value: SCDO:0000472 "At most severe form - lead to nephrotic syndrome." xsd:string
property_value: SCDO:0000661 "Caused by a variety of kidney diseases, including sickle cell disease, diabetes, glomerular disease, arteriosclerosis." xsd:string
property_value: SCDO:0000662 "Elevated amounts of protein in the urine - typically greater than 300mg in 24 hrs." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000934
name: Provider Attitudes Toward Patients with Sickle Cell Disease
def: "This is a 17-item scale, separated into 4 subscales with good psychometric properties. Negative Attitudes Scale comprises six items grouped together (Mean=36.5, SD=21.9, Potential range = 0 to 100). Higher scores on this scale indicate an endorsement of more negative views about SCD patients. Positive Attitudes Scale comprises four items grouped together (Mean=45.7, SD=24.3, Potential range = 0 to 100). Higher scores indicate an endorsement of more positive views about SCD patients. Concern Raising Behaviors Scale comprises four items grouped together (Mean = 53.7, SD = 22.0, Potential range = 0 to 100). Higher scores indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern that the patient is inappropriately drug-seeking. Red-Flag Behaviors Scale comprises three items grouped together (Mean = 58.7, SD = 22.7, Potential range = 0 to 100). Higher scores on this scale indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern about patient drug-seeking." []
is_a: SCDO:0000947 ! Quality of Care Measure
property_value: http://purl.org/dc/elements/1.1/source "Haywood, Jr., C., Lanzkron, S., Hughes, MD3, Brown, R., Massa, M.,  Ratanawongsa, N., and Beach, MC. (2010). A Video-Intervention to Improve Clinician Attitudes Toward Patients with Sickle Cell Disease: The Results of a Randomized Experiment. J Gen Intern Med 26(5):518–23." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Haywood, Jr., C., Lanzkron, S., Hughes, MD3, Brown, R., Massa, M.,  Ratanawongsa, N., and Beach, MC. (2010). A Video-Intervention to Improve Clinician Attitudes Toward Patients with Sickle Cell Disease: The Results of a Randomized Experiment. J Gen Intern Med 26(5):518–23." xsd:string
property_value: SCDO:0000470 "African Americans" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Heath care providers" xsd:string
property_value: SCDO:0001033 "Demonstrated validity with SCD populations in the US" xsd:string
property_value: SCDO:0001222 "Adults" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000935
name: Pruritus
def: "Pruritus, or itch, is defined as an unpleasant sensation that provokes the desire to scratch." []
synonym: "Itchy Skin" EXACT []
synonym: "Skin Itching" EXACT []
xref: HP:0000989
is_a: HP:0000961 ! Cyanosis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Suggest update to description. The current description seems to be describing two different things in the same description." xsd:string
property_value: SCDO:0000340 HP:0000989
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000937
name: Psychological Stress
def: "Stress wherein emotional factors predominate." []
synonym: "Emotional Stress" EXACT []
synonym: "Life Stress" EXACT []
synonym: "Psychological Suffering" EXACT []
xref: MESH:D013315
is_a: SCDO:0000746 ! Mental Health
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D013315
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000937 xsd:string

[Term]
id: SCDO:0000938
name: Psychosocial Deprivation
def: "The absence of appropriate stimuli in the physical or social environment which are necessary for the emotional, social, and intellectual development of the individual." []
synonym: "Psychosocial Deprivations" EXACT []
xref: MESH:D011610
is_a: SCDO:0000299 ! Culture
is_a: SCDO:0000746 ! Mental Health
property_value: SCDO:0000303 "This term is placed below \"Culture\" in MESH." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011610 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000938 xsd:string

[Term]
id: SCDO:0000940
name: Psychotherapy
def: "A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication." []
synonym: "Logotherapy" EXACT []
synonym: "Psycho-Therapy" EXACT []
xref: MESH:D011613
is_a: SCDO:0001129 ! Supportive Therapeutics
relationship: SCDO:1000018 SCDO:0000360 ! treats Depression
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011613 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000940 xsd:string

[Term]
id: SCDO:0000941
name: obsolete Publication Type
def: "'Describes the type of material the article represents (e.g., Review, Clinical Trial, Retracted Publication, Letter); see the PubMed Publication Types, e.g., review[pt]. Publication Types are arranged hierarchically with more specific terms arranged beneath broader terms. [Curator team: []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/EDDA_PT?p=classes&conceptid=http%3A%2F%2Fontologies.dbmi.pitt.edu%2Fedda%2FPublicationType.owl%23publication_type xsd:string
is_obsolete: true

[Term]
id: SCDO:0000942
name: Pulmonary Function Test
def: "Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc." []
synonym: "Lung Function Test" EXACT []
synonym: "PFT" EXACT []
synonym: "Respiratory Function Test" EXACT []
xref: MESH:D012129
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012129
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000942 xsd:string

[Term]
id: SCDO:0000943
name: Pulmonary Hypertension
def: "An elevation of mean pulmonary arterial systolic pressure (mPASP) (>20 mmHg at rest or >30 mmHg with exercise). The 6th World Symposium on PH reduced it from >25mmHg to >20mmHg for at rest, but did not adjust the definition for PH with exercise." []
comment: Pulmonary hypertension can be secondary to known cardiac, pulmonary, or hepatic disease. If no cause is identifiable, the term primary pulmonary hypertension is used.
synonym: "Increased Blood Pressure in Blood Vessels of Lungs" EXACT []
synonym: "Pulmonary Arterial Hypertension" EXACT []
is_a: HP:0000822 ! Hypertension
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000787 ! diagnosed using tool N-terminal Pro-brain Natriuretic Peptide Test
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/source https://erj.ersjournals.com/content/53/1/1802148
property_value: SCDO:0000340 "Br J Haematol. 2006 Jul;134(1):109-15." xsd:string
property_value: SCDO:0000340 "Simonneau et al 2013 J Am Coll Cardiol; Ataga et al." xsd:string
property_value: SCDO:0000661 "Multifactorial, including chronic thromboembolism, splenectomy, high cardiac output, left-heart disease, and hyperviscosity; the role of an inactivation of nitric oxide by free plasma hemoglobin due to chronic hemolysis is controversial." xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000944
name: Pulse Oximeter
def: "A measurement device, usually attached to the earlobe or fingertip, that measures the oxygen saturation of arterial blood." []
synonym: "Blood Oxygen Monitor" EXACT []
synonym: "Oxygen Monitor" EXACT []
xref: ERO:0000876
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:0000474 SCDO:0000885 ! has output measurement Peripheral Oxygen Saturation
relationship: SCDO:1000191 SCDO:0000945 ! used by diagnostic tool Pulse Oximetry (Rest)
property_value: SCDO:0000303 "This consists of 2 parts, the \"pulse oximeter monitor\" and the \"pulse oximeter probe\". Perhaps can be included as sub-classes or siblings? See \"Pulse Oximetry (Rest)\" in PhenX." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0000876 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000944 xsd:string

[Term]
id: SCDO:0000945
name: Pulse Oximetry (Rest)
def: "The application of pulse oximetry to measure a patient's saturation of oxyhemoglobin when the patient is at rest." []
xref: phenX:91102
is_a: NCIT:C38085 ! Pulse Oximetry
relationship: SCDO:1000192 SCDO:0000944 ! uses diagnostic device Pulse Oximeter
relationship: SCDO:1000194 SCDO:0000885 ! measures Peripheral Oxygen Saturation
property_value: SCDO:0000303 "Suggest update to description in PhenX\n\nSuggest inclusion of term below \"Pulse Oximetry\" in the CMO." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/91102
property_value: SCDO:0000479 "PhenX protocol: Pulse Oximetry (Rest) #91102" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000947
name: Quality of Care Measure
def: "The systemic measurement of the quality of health care that includes a broad set of perfomance measures such as the quality of services and the outcomes analysis for particular diseases and conditions, mortality and morbidity, patient safety, data on maternal and child health, as well as evaluation of quality of diagnosis, care accessibility, implementation of proven evidence-based practices, quality of reporting systems for errors and adverse events, reliability and accessibility of health and health care-related information, and health care organizations infrastructure." []
synonym: "Health Care Quality Assessment" EXACT []
synonym: "Quality of Health Care Assessment" EXACT []
xref: EDDA:health_care_quality_assessment
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: SCDO:0000303 "Suggest update to description in EDDA (replace \"excessability\" with \"accessibility\"." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/EDDA?p=classes&conceptid=http%3A%2F%2Fontologies.dbmi.pitt.edu%2Fedda%2FStudyDesigns.owl%23health_care_quality_assessment
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000948
name: Quality of Health Care
def: "The levels of excellence which characterize the health service or health care provided based on accepted standards of quality." []
synonym: "Health Care Quality" EXACT []
synonym: "Healthcare Quality" EXACT []
synonym: "Quality of Healthcare" EXACT []
xref: MESH:D011787
is_a: SCDO:0000950 ! Quality of Life and Care
relationship: SCDO:1000015 NCIT:C17047 ! modifies Quality of Life
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011787 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000948 xsd:string

[Term]
id: SCDO:0000950
name: Quality of Life and Care
def: "The subjective measurement of an individual's sense of well-being and ability to enjoy life, and the levels of excellence which characterize the health service or health care provided to individuals based on accepted standards of quality." []
is_a: SCDO:0001000 ! SCDO
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://pediatrics.aappublications.org/content/130/5/926
property_value: SCDO:0000303 "Request inclusion into relevant ontology.\n\nInclude the term \"Transition from pediatric care\" somewhere...see the source provided here." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000951
name: Quality of Life and Care Measure
def: "A measurement tool that is useful in aiding routine clinical practice with regard to quality of life and/or quality of care." []
synonym: "Quality of Life and Care Measurement Scales" EXACT []
is_a: SCDO:0000950 ! Quality of Life and Care
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000952
name: Quality of Life in Sickle Cell Disease Measure
def: "A questionnaire to assess the physical, emotional, and social impact of chronic conditions, such as sickle cell disease (SCD)." []
synonym: "Quality of Life in SCD" EXACT []
xref: phenX:820200
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000005 SCDO:0000234 ! modified by Chronic Sickle Cell Pain Management
relationship: SCDO:1000005 SCDO:0000895 ! modified by Phenotype of Sickle Cell Disease
relationship: SCDO:1000005 SCDO:0001023 ! modified by SCD Related Pain
relationship: SCDO:1000005 SCDO:0001052 ! modified by Sickle Cell Pain Management
property_value: SCDO:0000303 "Suggest update to label in PhenX." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F820200
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0000953
name: Quality of Life Measure
def: "A measurement tool with eight potential uses in aiding routine clinical practice. It can be used to prioritise problems, facilitate communication, screen for potential problems, identify preferences, monitor changes or response to treatment, and train new staff. It can also be used in clinical audit and in clinical governance. The first five of these can be used in the clinical encounter, while the last three contribute to training, reviewing care, and improving care in the future." []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1120388/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000954
name: Quality of Life Related SCD Symptoms and Complications
def: "Sickle cell symptoms where there is evidence of some relation with quality of life." []
is_a: NCIT:C17047 ! Quality of Life
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Probably too specific to be included in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000955
name: Quality-Adjusted Life Year (QALY)
def: "QALYs are used primarily to correct a person's life expectancy based on the levels of health-related quality of life they are predicted to experience throughout the course of their life, or part of it." []
comment: The number of QALYs lived by an individual in one year is simply: QALYs lived in one year = 1 * Q with Q <= 1; where Q is the health-related quality of life weight attached to the relevant year of life. I.e. QALY assumes a utility value (quality of life) of 1 = perfect health and a utility value of 0 = dead: Years of Life x Utility Value = Number of QALYs. E.g. If a person lives in perfect health for one year, that person will have 1 QALY (1 Year of Life x 1 Utility Value = 1 QALY), If a person lives in perfect health but only for half a year, that person will have 0.5 QALYs (0.5 Years of Life x 1 Utility Value = 0.5 QALYs) OR if a person lives for 1 year in a situation with 0.5 utility (half of perfect health), that person will also have 0.5 QALYs (1 Year of Life x 0.5 Utility Value = 0.5 QALYs). In cost-effectiveness evaluations the QALY is used to quantify the effectiveness of, for instance, a new medication versus the current one. In other words, the current standard of care is taken as the baseline, and the QALYs gained from the new (improved) intervention are counted in addition.
synonym: "QALY" EXACT []
synonym: "Quality-Adjusted Life Year" EXACT []
is_a: SCDO:0000495 ! Health Utility
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self; Proxy" xsd:string
property_value: SCDO:0000482 "All" xsd:string
property_value: SCDO:0001033 "Standard global assessment of health interventions, also used in SCD studies" xsd:string
property_value: SCDO:0001222 "Children and adults" xsd:string
property_value: SCDO:0001335 "no" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0000957
name: obsolete Questionnaire
def: "'Collection of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. [Curator team: []]'" []
xref: MESH:D011795
is_a: SCDO:1000034 ! from diagnostics
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/MESH?p=classes&conceptid=D011795 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000963
name: Radiography
def: "Examination of any part of the body for diagnostic purposes by means of x-rays or gamma rays, recording the image on a sensitized surface (such as photographic film)." []
synonym: "Imaging by X-Ray" EXACT []
synonym: "X-Ray" EXACT []
xref: MESH:D011859
is_a: OBI:0000185 ! Imaging Assay
relationship: SCDO:1000192 OBI:0001138 ! uses diagnostic device X-Ray Machine
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011859 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000963 xsd:string

[Term]
id: SCDO:0000964
name: Radionuclide Imaging
def: "The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph." []
synonym: "Imaging by Radionuclide" EXACT []
synonym: "Scintigraphy" EXACT []
xref: MESH:D011877
is_a: OBI:0000185 ! Imaging Assay
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011877 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000964 xsd:string

[Term]
id: SCDO:0000965
name: obsolete Randomized Controlled Trial
def: "'A work that reports on a clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. [Curator team: []]'" []
xref: MESH:D016449
is_a: SCDO:0000283 ! obsolete Controlled Clinical Trial
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016449 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000966
name: Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen)
def: "The Rapid Estimate of Adolescent Literacy or REALM-Teen is a valid, reliable, easy-to-administer tool that will allow health professionals to screen youth in grades 6-12 for below-grade reading. The REALM-Teen is a reading recognition instrument, modeled after the Rapid Estimate of Adult Literacy in Medicine (REALM), the most commonly used tool to screen adults for low literacy in health care settings. The REALM-Teen is a reading recognition instrument which measures an individual's ability to pronounce words in ascending order of difficulty. All test words are commonly used adolescent health terms." []
synonym: "Rapid Estimate of Adolescent Literacy in Medicine" EXACT []
synonym: "REALM-Teen" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "Davis TC, Wolf MS, Arnold CL, Byrd RS, Long SW, Springer T, Kennen E, Bocchini JA. (2006). Development and validation of the Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen): a tool to screen adolescents for below-grade reading in health care settings. Pediatrics 118(6):e1707-14." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\".\n\nAdd these annotation properties: -- has cross-cultural adaptation -- freely available -- has translations" xsd:string
property_value: SCDO:0000340 "Davis TC, Wolf MS, Arnold CL, Byrd RS, Long SW, Springer T, Kennen E, Bocchini JA. (2006). Development and validation of the Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen): a tool to screen adolescents for below-grade reading in health care settings. Pediatrics 118(6):e1707-14." xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Adolescents with SCD" xsd:string
property_value: SCDO:0001033 "Used in SCD studies" xsd:string
property_value: SCDO:0001222 "Adolescents" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000970
name: Recovery and Recurrence Questionnaire (RRQ)
def: "A questionnaire that assesses recovery and recurrence of stroke in children. It is completed by a parent about their child." []
synonym: "Recovery and Recurrence Questionnaire (RRQ) - Pediatrics" EXACT []
synonym: "RRQ" EXACT []
xref: phenX:820702
is_a: SCDO:0001339 ! Functionality After Stroke Measure
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to description in PhenX." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820702 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Recovery and Recurrence Questionnaire (RRQ) - Pediatrics #820702" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000972
name: Recurrent Wheeze in Sickle Cell Disease
def: "Recurrent episodes of wheezing in persons with SCD who have no co-morbid asthma." []
synonym: "RWIS" EXACT []
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000580 ! treated with Hydroxyurea
property_value: SCDO:0000303 "Probably too specific to warrant inclusion into anther ontology." xsd:string
property_value: SCDO:0000340 "Glassberg et al 2014 Curr Opin Pediatr." xsd:string
property_value: SCDO:0000340 "Knight-Madden et al 2014 Ped Resp Rev" xsd:string
property_value: SCDO:0000661 "Likely related to inflammation of SCD." xsd:string
property_value: SCDO:0000662 "Other markers of severity of SCD- eg  complications of SCD, high LDH." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000975
name: Red Blood Cell Microparticles Level
def: "The amount of red blood cell derived microparticles in a specific volume of blood." []
synonym: "Cell-Derived Microparticles" BROAD []
synonym: "EMP Level" EXACT []
synonym: "Erythrocyte-Derived Microparticles Level" EXACT []
synonym: "Level of Red Blood Cell Microparticles" EXACT []
synonym: "RBC Microparticles Level" EXACT []
synonym: "Red Blood Cell Derived Microparticles Level" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1000190 SCDO:0001326 ! obtained via diagnostic tool Flow Cytometry
relationship: SCDO:1000190 SCDO:1000314 ! obtained via diagnostic tool Red Blood Cell Microparticles Assay
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678264/
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nMore info can be taken from the dc:source provided.\n\nPerhaps add MeSH term \"Cell-Derived Microparticles\" as a superclass of this term?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000976
name: Reduced Hemoglobin A
def: "Hemoglobin A (HbA) contains two alpha-globin chains and two beta-globin chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decrease in the proportion of HbA below this limit, and can be seen in various forms of thalassemia." []
xref: HP:0011905
is_a: HP:0020062 ! Decreased Hemoglobin Concentration
is_a: SCDO:1000061 ! Altered Level of Normal Hemoglobin in SCD
relationship: SCDO:1000202 SCDO:0000042 ! caused by Alpha Thalassemia
relationship: SCDO:1000210 SCDO:0000042 ! has causal or contributing genetic variation Alpha Thalassemia
relationship: SCDO:1000210 SCDO:0009731 ! has causal or contributing genetic variation Beta Thalassemia Mutation
property_value: SCDO:0000303 "Suggest update to description in HPO." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0011905 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000978
name: Rehabilitation
def: "Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury." []
synonym: "Habilitation" EXACT []
xref: MESH:D012046
is_a: SCDO:0001129 ! Supportive Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012046 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000978 xsd:string

[Term]
id: SCDO:0000979
name: Reincarnation
def: "Reincarnation is the philosophical or religious concept that an aspect of a living being starts a new life in a different physical body or form after each biological death." []
synonym: "Rebirth" EXACT []
synonym: "Transmigration" EXACT []
is_a: SCDO:0000107 ! Beliefs About Causes of Illness
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Reincarnation xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0000981
name: Religion
def: "A set of beliefs concerning the nature, cause, and purpose of the universe, especially when considered as the creation of a superhuman agency. It usually involves devotional and ritual observances and often a moral code for the conduct of human affairs." []
synonym: "Religious Beliefs" EXACT []
synonym: "Religious Ethics" EXACT []
xref: MESH:D012067
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:0000299 ! Culture
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012067 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000981 xsd:string

[Term]
id: SCDO:0000983
name: Renal Dialysis
def: "Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, peritoneal dialysis, and hemodiafiltration." []
synonym: "Dialyses, Renal" EXACT []
synonym: "Extracorporeal Dialyses" EXACT []
synonym: "Extracorporeal Dialysis" EXACT []
synonym: "Haemodialysis" EXACT []
synonym: "Hemodialyses" EXACT []
synonym: "Renal Dialyses" EXACT []
xref: MESH:D006435
is_a: SCDO:1000004 ! Renal Replacement Therapy
relationship: SCDO:1000018 HP:0001298 ! treats Encephalopathy
relationship: SCDO:1000018 HP:0001919 ! treats Acute Kidney Injury
relationship: SCDO:1000018 HP:0002157 ! treats Azotaemia
relationship: SCDO:1000018 HP:0002913 ! treats Myoglobinuria
relationship: SCDO:1000018 HP:0003774 ! treats End Stage Kidney Disease
relationship: SCDO:1000018 HP:0008682 ! treats Acute Tubular Necrosis
relationship: SCDO:1000018 SCDO:0000226 ! treats Chronic Kidney Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Include types of renal dialysis as sub-classes: -- Peritoneal dialysis -- Hemodialysis -- Pediatric dialysis? -- Hemofiltration -- Hemodiafiltration" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006435 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000983 xsd:string

[Term]
id: SCDO:0000984
name: Renal Ischemia
def: "Inadequate blood flow to one or both kidneys, or nephrons, usually due to functional constriction or actual obstruction of blood vessels." []
synonym: "Kidney Ischaemia" EXACT []
synonym: "Kidney Ischemia" EXACT []
synonym: "Nephric Ischaemia" EXACT []
synonym: "Nephric Ischemia" EXACT []
synonym: "Renal Ischaemia" EXACT []
xref: MP:0011758
is_a: HP:0000077 ! Abnormality of the Kidney
is_a: SCDO:0000665 ! Ischemia
is_a: SCDO:1000383 ! Renal Complication
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000664 SCDO:0001129 ! treated with Supportive Therapeutics
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Suggest update to description in Mammalian Phenotype ontology.\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000340 MP:0011758
property_value: SCDO:0000661 "Loss of adequate blood flow may be due to obstruction of blood vessels - large or small or due to low flow states such as prolonged hypotension." xsd:string
property_value: SCDO:0000662 "Usually associated with kidney injury as noted by decrease in urine output and/or elevation in serum creatinine." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000985
name: Renal Transplant
def: "The transference of a kidney from one human or animal to another." []
synonym: "Kidney Grafting" EXACT []
synonym: "Kidney Transplant" EXACT []
synonym: "Kidney Transplantation" EXACT []
synonym: "Kidney Transplantations" EXACT []
synonym: "Renal Transplantation" EXACT []
synonym: "Renal Transplantations" EXACT []
xref: MESH:D016030
is_a: SCDO:1000004 ! Renal Replacement Therapy
relationship: SCDO:1000018 HP:0003774 ! treats End Stage Kidney Disease
relationship: SCDO:1000018 SCDO:0000226 ! treats Chronic Kidney Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016030 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000985 xsd:string

[Term]
id: SCDO:0000986
name: Renal Tubular Acidosis
def: "Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia." []
synonym: "Accumulation of Acid in Body Due to Kidney Problem" EXACT []
synonym: "RTA" EXACT []
xref: HP:0001947
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Suggest update to description in HPO.\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0001947
property_value: SCDO:0000472 "Has multiple types - Type 1 (Distal RTA), Type 2 (Proximal RTA), Type 4 (Hyperkalemic RTA). Sickle cell disease may demonstrate a voltage dependent Type 1 RTA." xsd:string
property_value: SCDO:0000661 "Defects in the kidneys in reabsorption of bicarbonate (HCO3), the excretion of hydrogen ions (H+), or both." xsd:string
property_value: SCDO:0000662 "A relatively normal GFR and a metabolic acidosis accompanied by hyperchloremia and a normal plasma anion gap." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0000987
name: Reproductive History Diagnostic Instrument
def: "A questionnaire to assess either male or females' pregnancy history. Females are asked about the number of pregnancies, description of pregnancies and smoking during pregnancy. Males are asked whether they have ever fathered a pregnancy and, if so, the description of the pregnancy." []
xref: phenX:101300
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
property_value: SCDO:0000303 "Suggest update to labels of as we have done. We are using \"Reproductive History\" below Personal Attribute.\nAlso suggest update to description as we have done." xsd:string
property_value: SCDO:0000340 "details"
property_value: SCDO:1000288 "Suggest update to label and description" xsd:string

[Term]
id: SCDO:0000988
name: deprecated Reproductive System
def: "'Anatomical system that has as its parts the organs concerned with reproduction. [Curator team: []]'" []
xref: UBERON:0000990
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/UBERON_0000990 xsd:string
is_obsolete: true
replaced_by: SCDO:1000263

[Term]
id: SCDO:0000990
name: obsolete Research Activity
def: "'Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered. [Curator team: []]'" []
xref: NCIT:C15429
is_a: SCDO:1000031 ! from personal attribute
property_value: SCDO:0000303 "Consider other sub-classes of this in NCIT." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C15429 xsd:string
is_obsolete: true

[Term]
id: SCDO:0000993
name: Respiratory Rate
def: "The number of times an organism breathes with the lungs (respiration) per unit time, usually per minute." []
synonym: "Breathing Frequency" EXACT []
synonym: "Pulmonary Ventilation Rate" EXACT []
synonym: "Respiration Rate" EXACT []
xref: MESH:D056152
is_a: CMO:0000094 ! Respiratory System Measurement
relationship: SCDO:1000772 NCIT:C50474 ! has possible finding Bradypnea
relationship: SCDO:1000772 NCIT:C50767 ! has possible finding Tachypnea
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D056152
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000993 xsd:string

[Term]
id: SCDO:0000994
name: deprecated Respiratory System
def: "Lungs and respiratory system of the body." []
synonym: "Pulmonary System" EXACT []
is_a: SCDO:0001336 ! from phenotype
is_obsolete: true
replaced_by: SCDO:0004899

[Term]
id: SCDO:0001000
name: SCDO
def: "Root of all terms in the Sickle Cell Disease Ontology, an effort of unambiguously describing all concepts and unifying up-to-date knowledge in sickle cell disease." []
synonym: "Sickle Cell Disease Ontology" EXACT []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Gaston K. Mazandu)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001002
name: Restriction Fragment Length Polymorphism PCR
def: "PCR-restriction fragment length polymorphism (RFLP)-based analysis, also known as cleaved amplified polymorphic sequence (CAPS), is a popular technique for genetic analysis. It has been applied for the detection of intraspecies as well as interspecies variation. There exist several techniques that are related with PCR-RFLP and also involve gel electrophoresis including techniques for DNA fingerprinting and expression profiling." []
synonym: "PCR-RFLP" EXACT []
synonym: "Restriction Fragment Length Polymorphism - Polymerase Chain Reaction" EXACT []
is_a: SCDO:0000913 ! Polymerase Chain Reaction
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 "Henrik Berg Rasmussen (April 4th 2012). Restriction Fragment Length Polymorphism Analysis of PCR-Amplified Fragments (PCR-RFLP) and Gel Electrophoresis - Valuable Tool for Genotyping and Genetic Fingerprinting, Gel Electrophoresis Sameh Magdeldin, IntechOpen, DOI: 10.5772/37724. Available from: https://www.intechopen.com/books/gel-electrophoresis-principles-and-basics/restriction-fragment-length-polymorphism-analysis-of-pcr-amplified-fragments-pcr-rflp-and-related-te" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001004
name: Reticulocyte Count
def: "The number of reticulocytes per unit volume of blood. The values are expressed as a percentage of the erythrocyte count or in the form of an index (\"corrected reticulocyte index\"), which attempts to account for the number of circulating erythrocytes." []
synonym: "Reticulocyte Number" EXACT []
xref: MESH:D017701
is_a: CMO:0000025 ! Red Blood Cell Count
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:1000686 ! obtained via diagnostic tool Reticulocyte Count Assay
relationship: SCDO:1000772 HP:0001896 ! has possible finding Reticulocytopenia
relationship: SCDO:1000772 HP:0001923 ! has possible finding Reticulocytosis
relationship: SCDO:1000772 SCDO:1000834 ! has possible finding Normal Reticulocyte Count
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017701
property_value: SCDO:0000479 "PhenX protocol: Reticulocyte Count #810601" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001004 xsd:string

[Term]
id: SCDO:0001005
name: Reticulocyte Count by Hematology Analyzer
def: "A reticulocyte count that was performed with an electronic haematology analyzer." []
is_a: SCDO:0001004 ! Reticulocyte Count
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001006
name: Reticulocyte Count by Microsocopy
def: "A reticulocyte count that was performed with microscopy." []
is_a: SCDO:0001004 ! Reticulocyte Count
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001007
name: Retinal Cryopexy
def: "A procedure that uses intense cold to induce a chorioretinal scar and to destroy retinal or choroidal tissue." []
synonym: "Retinal Cryotherapy" EXACT []
is_a: SCDO:0000833 ! Ophthalmologic Surgical Procedure
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.surgeryencyclopedia.com/Pa-St/Retinal-Cryopexy.html xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001008
name: Retinal Detachment
def: "Separation of the retina from the choroid and eye wall due to holes in the retina and traction on the retina by vitreous bands and condensed preretinal membranes (usually as sequelae of proliferative sickle retinopathy). Retinal detachment is the most severe complication (Stage V) of proliferative sickle retinopathy." []
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:0000663 NCIT:C101217 ! diagnosed using tool Retinal Examination
relationship: SCDO:0000663 NCIT:C75583 ! diagnosed using tool Slit-Lamp Examination
relationship: SCDO:0000663 SCDO:0000835 ! diagnosed using tool Ophthalmoscopy
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "We provided a more SCD specific description than the generic descriptions provided in existing ontologies." xsd:string
property_value: SCDO:0000340 "Ballas et al 2010 Am J Hematol" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0001010
name: Retrospective Studies
def: "Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons." []
synonym: "Retrospective Study" EXACT []
xref: MESH:D012189
is_a: SCDO:0000263 ! Cohort Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012189 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001010 xsd:string

[Term]
id: SCDO:0001017
name: Rural Location
def: "An open swath of land that has few homes or other buildings, and not very many people." []
synonym: "Rural" EXACT []
synonym: "Rural Area" EXACT []
synonym: "Rural Setting" EXACT []
is_a: GAZ:00000448 ! Geographic Location
is_a: SCDO:0000496 ! Healthcare Access
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.nationalgeographic.org/encyclopedia/rural-area/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001019
name: Salmon Patch Hemorrhage
def: "Round or oval-shaped intraretinal accumulation of erythrocytes that may be up to 2 mm in diameter. This small intraretinal hematoma is initially red and becomes salmon colored with time." []
synonym: "Salmon Patch Hemorrhages" EXACT []
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:0000663 NCIT:C75583 ! diagnosed using tool Slit-Lamp Examination
relationship: SCDO:0000663 SCDO:0000835 ! diagnosed using tool Ophthalmoscopy
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 "Ballas et al 2010 Am J Hematol" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001020
name: Sampling Studies
def: "Studies in which a number of subjects are selected from all subjects in a defined population. Conclusions based on sample results may be attributed only to the population sampled." []
synonym: "Probability Sample" EXACT []
synonym: "Probability Samples" EXACT []
synonym: "Sampling Study" EXACT []
xref: MESH:D012494
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012494 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001020 xsd:string

[Term]
id: SCDO:0001023
name: SCD Related Pain
def: "Pain resulting from the presence of Sickle Cell Disease (SCD). Such pain can be acute, chronic or a mixture of the two." []
synonym: "SCD Pain" EXACT []
synonym: "SCD-Related Pain" EXACT []
is_a: SCDO:0000851 ! Pain
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1000015 SCDO:0000952 ! modifies Quality of Life in Sickle Cell Disease Measure
relationship: SCDO:1000202 SCDO:1000106 ! caused by Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Okpala I., Tawil A. Management of pain in sickle-cell disease. Journal of the Royal Society of Medicine. 2002;95(9):456-458. doi: 10.1258/jrsm.95.9.456" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001025
name: Scleral Buckling
def: "An operation for retinal detachment which reduces the size of the globe by indenting the sclera so that it approximates the retina." []
synonym: "Scleral Buckle Surgery" EXACT []
synonym: "Scleral Bucklings" EXACT []
xref: MESH:D012591
is_a: SCDO:0000833 ! Ophthalmologic Surgical Procedure
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012591 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001025 xsd:string

[Term]
id: SCDO:0001027
name: Secondary Healthcare
def: "Specialized healthcare delivered as a follow-up or referral from a primary care provider." []
synonym: "Secondary Care" EXACT []
synonym: "Secondary Health Care" EXACT []
xref: MESH:D063127
is_a: SCDO:0000494 ! Health System
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D063127 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001027 xsd:string

[Term]
id: SCDO:0001029
name: Sedentary Lifestyle
def: "Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week." []
xref: MESH:D057185
is_a: SCDO:0000689 ! Lifestyle
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D057185 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001029 xsd:string

[Term]
id: SCDO:0001034
name: Self Care
def: "Caring for self when ill or positive actions and adopting behaviors to prevent illness." []
synonym: "Self Management" EXACT []
synonym: "Self-Care" EXACT []
synonym: "Self-Management" EXACT []
xref: MESH:D012648
is_a: SCDO:0000978 ! Rehabilitation
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012648 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001034 xsd:string

[Term]
id: SCDO:0001035
name: Self Efficacy
def: "Cognitive mechanism based on expectations or beliefs about one's ability to perform actions necessary to produce a given effect." []
synonym: "Self-Concept" EXACT []
xref: MESH:D020377
is_a: SCDO:0000286 ! Coping Skill
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D020377
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001035 xsd:string

[Term]
id: SCDO:0001037
name: Self-Reported Weight
def: "The weight in kilograms or pounds as reported by the participant." []
is_a: SCDO:0000152 ! Body Weight
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001041
name: Seroepidemiologic Studies
def: "Epidemiologic studies based on the detection through serological testing of characteristic change in the serum level of specific antibodies. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases." []
synonym: "Seroprevalences" EXACT []
xref: MESH:D016036
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016036 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001041 xsd:string

[Term]
id: SCDO:0001043
name: Serum HDL Cholesterol Level
def: "The amount of the HDL cholesterol, the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion, in a specified volume of serum." []
synonym: "Blood HDL Cholesterol Amount" EXACT []
synonym: "Blood High Density Lipoprotein Cholesterol Amount" EXACT []
synonym: "Circulating HDL Cholesterol Amount" EXACT []
synonym: "Circulating HDL Cholesterol Level" EXACT []
synonym: "HDL Cholesterol Level" EXACT []
synonym: "HDL Level" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1000190 SCDO:1000315 ! obtained via diagnostic tool Serum HDL Cholesterol Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 VT:0000184
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001044
name: SF-36v2 Health Survey
def: "A 36-item instrument for measuring health status and outcomes via patient self-report. It is designed for use in surveys of general and specific populations, health policy evaluations, and clinical practice and research. The SF-36v2 measures the following eight health concepts, which are relevant across age, disease, and treatment groups: physical functioning, role limitations due to physical health problems, bodily pain, general health, vitality (energy/fatigue), social functioning, role limitations due to emotional problems, and mental health (psychological distress and psychological well-being). Both standard (4-week) and acute (1-week) recall versions are available. The survey's standardized scoring system yields a profile of eight health scores and two summary measures (physical and mental health) and a self-evaluated change in health status." []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: SCDO:0000303 "Add these annotation properties: -- has cross-cultural adaptation -- freely available -- has translations" xsd:string
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Physical, Social, and Mental Health Functioning (SF-36V2)\")" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/191201
property_value: SCDO:0000479 "PhenX protocol: #191201" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Healthy people; Clinic patients" xsd:string
property_value: SCDO:0001033 "Demonstrated validity with SCD populations; multiple publications using the measure in SCD; very widely used with healthy populations and those with chronic conditions" xsd:string
property_value: SCDO:0001222 "Adults 18 years and older" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001047
name: Sickle Cell Disease Health-Related Stigma Scale (SCD-HRSS)
def: "A measure of stigma among adults living with Sickle Cell disease. Focus on; depressive symptoms, pain, assertive communication, satisfaction with pain management experience, and health-related stigma." []
synonym: "SCD-HRSS" EXACT []
synonym: "Sickle Cell Disease Health-Related Stigma Scale" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "Jenerette C, Brewer CA, Crandell J, Ataga KI. Preliminary validity and reliability of the Sickle Cell Disease Health-Related Stigma Scale.Issues Ment Health Nurs.2012 Jun;33(6):363-9." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\".\n\nAdd these annotation properties: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations" xsd:string
property_value: SCDO:0000340 "Jenerette C, Brewer CA, Crandell J, Ataga KI. Preliminary validity and reliability of the Sickle Cell Disease Health-Related Stigma Scale.Issues Ment Health Nurs.2012 Jun;33(6):363-9." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001048
name: Sickle Cell Disease Pain Burden Interview - Youth
def: "The SCPBI-Y is a brief clinical interview designed to assess pain burden for children and adolescents with SCD." []
synonym: "SCPBI-Y" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\".\n\nAdd these annotation properties: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations" xsd:string
property_value: SCDO:0000340 "Zempsky WT, O'Hara EA, Santanelli JP, Palermo TM, New T, Smith-Whitley K, Casella JF. Validation of the sickle cell disease pain burden interview-youth. J Pain. 2013 Sep;14(9):975-82." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001049
name: Sickle Cell Disease Screening Test
def: "Sickle cell tests are used to help diagnose sickle cell anemia (also called sickle cell disease) and to identify those who may have sickle cell trait. Sickle cell anemia is an inherited disorder that leads to the production of an abnormal hemoglobin called hemoglobin S (Hb S or Hgb S). Sickle cell tests determine the presence and relative amount of hemoglobin S in a blood sample." []
synonym: "Screening for Sickle Cell Disease" EXACT []
is_a: SCDO:0000781 ! Mutation Carrier Screening
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://labtestsonline.org/tests/sickle-cell-tests xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001050
name: Sickle Cell Disease Self-Efficacy Scale
def: "A nine-item self-administered questionnaire that measures disease-specific perceptions of the ability to manage day-to-day issues resulting from sickle cell disease (SCD). Items are scores according to a five-point scale ranging from 1 - Not sure at all to 5 - Very sure. Responses from individual items are summed to give an overall score with higher scores indicating greater self-efficacy." []
synonym: "Scale of Self-efficacy in Sickle Cell Disease" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/820401?pageLink=browse.protocoldetails&id=820401
property_value: SCDO:0000303 "Suggest update to label in PhenX as we have done." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/820401?pageLink=browse.protocoldetails&id=820401
property_value: SCDO:0000479 "PhenX protocol: Self-efficacy in Sickle Cell Disease #820401" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Clinic Patients (Adults with SCD)" xsd:string
property_value: SCDO:0000486 "Self-efficacy, or one’s perceptions that they can exercise control over their behaviors and environment, may play an important role in determining the ability to adjust to chronic conditions such as sickle cell disease (SCD)." xsd:string
property_value: SCDO:0001222 "18 and older" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001051
name: Variant Sickle Cell Syndrome
def: "A variant form of sickle cell disease that results from inheriting the sickle mutation in combination with another beta-globin gene mutation. These hemoglobinopathies may have different clinical severity compared to the homozygous form of sickle cell disease (HbSS)." []
synonym: "SCD Variant" EXACT []
synonym: "Sickle Cell Disease Variant" EXACT []
synonym: "Variant Sickle Cell Syndromes" EXACT []
is_a: SCDO:1000106 ! Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.uptodate.com/contents/overview-of-variant-sickle-cell-syndromes xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001052
name: Sickle Cell Pain Management
def: "A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing sickle cell related pain." []
synonym: "Sickle Cell Pain Managements" EXACT []
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000015 SCDO:0000952 ! modifies Quality of Life in Sickle Cell Disease Measure
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into MESH below \"Pain Management\"." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D059408 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001053
name: Sickle Cell Painful Event
def: "Pain lasting at least two hours that requires an unscheduled emergency room visit or hospitalization or that disrupts daily activities." []
synonym: "Pain Episode" EXACT []
synonym: "Painful Crisis" EXACT []
synonym: "Painful Event" EXACT []
synonym: "Sickle Cell Acute Pain Episode" EXACT []
synonym: "Sickle Cell Pain Episode" EXACT []
is_a: SCDO:0001023 ! SCD Related Pain
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=830101 xsd:string
property_value: SCDO:0000303 "Could be categorised as a phenotype \"Finding\"." xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001054
name: Sickle Cell Related Cancer
def: "A cancer that is almost exclusively associated with sickle cell trait and/or sickle cell disease." []
synonym: "Sickle Cell Associated Cancer" EXACT []
is_a: OBI:1110053 ! Cancer
property_value: http://purl.org/dc/elements/1.1/source "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001055
name: Sickle Cell Trait
def: "The condition of being heterozygous for hemoglobin S." []
synonym: "AS Genotype" EXACT []
synonym: "Haemoglobin Genotype AS" EXACT []
synonym: "Hemoglobin Genotype AS" EXACT []
xref: MESH:D012805
is_a: NCIT:C95534 ! Hemoglobin Trait
relationship: SCDO:0000469 SCDO:0000322 ! has clinical code D57.3 Sickle-cell trait
relationship: SCDO:1000172 SCDO:1000161 ! has causal genotype Hemoglobin Genotype AS
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000218 HP:0003158 ! has manifestation Hyposthenuria
relationship: SCDO:1000218 MP:0013305 ! has manifestation Isosthenuria
relationship: SCDO:1000218 SCDO:0000508 ! has manifestation Hematuria
relationship: SCDO:1000218 SCDO:0001511 ! has manifestation Renal Medullary Carcinoma
relationship: SCDO:1000218 SCDO:0002106 ! has manifestation Splenic Infarction
relationship: SCDO:1000218 SCDO:0009445 ! has manifestation Renal Papillary Necrosis
relationship: SCDO:1000223 SCDO:0004139 ! has causal molecular phenotype Adult Hemoglobin
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012805 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001055 xsd:string

[Term]
id: SCDO:0001056
name: Sickle Cell Disease-S Beta Minus Thalassemia
def: "A mild form of sickle cell thalassemia characterized by the presence of hemoglobin S and a reduced amount of hemoglobin A in the red blood cells. It is characterized by the presence of small red blood cells and mild anemia." []
synonym: "S beta-minus" EXACT []
synonym: "Sickle B- Thalassemia" EXACT []
synonym: "Sickle Beta Minus Thalassemia" EXACT []
synonym: "Sickle Cell Disease-S Beta Minus Thalassemia" EXACT []
synonym: "Sickle Cell-B- Thalassemia" EXACT []
synonym: "Sickle Cell-Beta Minus Thalassemia" EXACT []
xref: NCIT:C98837
is_a: NCIT:C95539 ! Sickle Beta Thalassemia
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0000664 NCIT:C561 ! treated with Ibuprofen
relationship: SCDO:0000664 SCDO:0000010 ! treated with Acetaminophen
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000159 ! has causal genotype Hemoglobin Genotype S/Beta Minus Thalassaemia
relationship: SCDO:1000210 SCDO:0001765 ! has causal or contributing genetic variation Beta-Minus Thalassemia Mutation
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000218 DOID:1584 ! has manifestation Acute Chest Syndrome
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000218 SCDO:0001111 ! has manifestation Stroke
relationship: SCDO:1000218 SCDO:0002106 ! has manifestation Splenic Infarction
relationship: SCDO:1000218 SCDO:0006905 ! has manifestation Hypersplenism
relationship: SCDO:1000218 SCDO:0009350 ! has manifestation Splenic Sequestration
relationship: SCDO:1000223 HP:0011906 ! has causal molecular phenotype Reduced Beta/Alpha Synthesis Ratio
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:0000976 ! has causal molecular phenotype Reduced Hemoglobin A
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "Suggest update to label in NCIT from \"Sickle Beta Plus Thalassemia\" to \"Sickle Beta Minus Thalassemia\"" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98837 xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001059
name: Sickle Cell Disease-SC
def: "One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia." []
synonym: "Hb SC-disease" EXACT []
synonym: "Hemoglobin S / Hemoglobin C Disease" EXACT []
synonym: "Hemoglobin SC Disease" EXACT []
synonym: "SC Disease" EXACT []
synonym: "Sickle Cell Disease SC" EXACT []
synonym: "Sickle Cell Hemoglobin C Disease" EXACT []
synonym: "Sickle Cell-Haemoglobin C Disease" EXACT []
synonym: "Sickle Cell-Hemoglobin C Disease" EXACT []
synonym: "Sickle-Cell/Hb-C Disease" EXACT []
xref: MESH:D006450
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
relationship: SCDO:0000469 SCDO:0000316 ! has clinical code D57.2 Sickle-cell/Hb-C disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000049 ! has causal genotype Hemoglobin Genotype SC
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000041 ! has causal or contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000218 EUPATH:0000215 ! has manifestation Severe Anemia
relationship: SCDO:1000223 SCDO:0000513 ! has causal molecular phenotype Hemoglobin C
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006450 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001059 xsd:string

[Term]
id: SCDO:0001061
name: Sickle Cell Disease-S/D-Punjab
def: "A rare compound heterozygous hemoglobinopathy characterised by the presence of two beta globin gene variants: that of hemoglobin S (beta-6(GAG-->GTG)) and that of hemoglobin D-Punjab (beta-121(GAA-->CAA))." []
synonym: "Haemoglobin S/D-Punjab" EXACT []
synonym: "Hemoglobin S/D-Punjab" EXACT []
synonym: "Sickle Cell-Haemoglobin D-Punjab" EXACT []
synonym: "Sickle Cell-Hemoglobin D-Punjab Disease" EXACT []
is_a: NCIT:C155310 ! Sickle Cell Disease-SD
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000050 ! has causal genotype Hemoglobin Genotype S/D-Punjab
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000109 ! has causal or contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:0000528 ! has causal molecular phenotype Hemoglobin D-Punjab
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/RCD/D1064
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Perhaps as sub-class of \"Sickle Cell-Hemoglobin D Disease\" in the NCIT." xsd:string
property_value: SCDO:0000340 "Rahimah Ahmad*, Syahira Lazira Omar*, Siti Hida H M Arif*, Faidatul Syazlin A Hamid*, Nur Aisyah Aziz*, Nik Hafidzah N Mustapha**, Zubaidah Zakaria*Haemoglobin Sickle D Punjab: - A Case Report. Med J Malaysia. 2014. Vol 69 No 1." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001062
name: Sickle Cell Disease-SE
def: "A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin E mutations, which can cause mild hemolytic anemia." []
synonym: "Hb SE-Disease" EXACT []
synonym: "Hemoglobin SE Disease" EXACT []
synonym: "Hemoglobin SE-Disease" EXACT []
synonym: "Sickle Cell Disease SE" EXACT []
synonym: "Sickle Cell-Haemoglobin E Disease" EXACT []
synonym: "Sickle Cell-Hemoglobin E Disease" EXACT []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000052 ! has causal genotype Hemoglobin Genotype SE
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000042 ! has causal or contributing genetic variation HBB, GLU26LYS
relationship: SCDO:1000218 DOID:1584 ! has manifestation Acute Chest Syndrome
relationship: SCDO:1000218 HP:0001081 ! has manifestation Cholelithiasis
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000218 HP:0001903 ! has manifestation Anemia
relationship: SCDO:1000218 HP:0010885 ! has manifestation Osteonecrosis
relationship: SCDO:1000218 NCIT:C35447 ! has manifestation Osteonecrosis of the Femoral Head
relationship: SCDO:1000218 SCDO:0000508 ! has manifestation Hematuria
relationship: SCDO:1000218 SCDO:0000851 ! has manifestation Pain
relationship: SCDO:1000218 SCDO:0001067 ! has manifestation Sickle Retinopathy
relationship: SCDO:1000218 SCDO:0002106 ! has manifestation Splenic Infarction
relationship: SCDO:1000218 SCDO:0009350 ! has manifestation Splenic Sequestration
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000009 ! has causal molecular phenotype Hemoglobin E
property_value: SCDO:0000303 "Suggest update to description of \"Sickle Cell-Hemoglobin D Disease\" in the NCIT." xsd:string
property_value: SCDO:0000340 http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-S-E xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0001063
name: Sickle Cell Disease-S/Lepore Boston
def: "Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three Hb Lepore variants described in association with HbS." []
comment: Hb Lepore Washington, also known as Hb Lepore Boston or Hb Lepore Washington-Boston; most common in Italians from Southern Italy.
synonym: "SCD-S/Lepore Boston" EXACT []
synonym: "Sickle Cell Disease-S/Lepore" EXACT []
synonym: "Sickle Cell-Hb Lepore Boston Syndrome" EXACT []
synonym: "Sickle Cell-Hemoglobin Lepore Boston Syndrome" EXACT []
is_a: NCIT:C95539 ! Sickle Beta Thalassemia
relationship: SCDO:0000663 CMO:0000364 ! diagnosed using tool Complete Blood Count
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000070 ! has causal genotype Hemoglobin Genotype S/Lepore Boston
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000209 ! has causal or contributing genetic variation Crossover between delta (HBD) and beta globin (HBB) gene loci
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000089 ! has causal molecular phenotype Hemoglobin Lepore Boston
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001064
name: Sickle Cell Disease-S/O-Arab
def: "One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin O-Arab. It can cause anemia, repeated infections, and periodic episodes of pain and organ damage." []
synonym: "Hb F,S,O-Arab" EXACT []
synonym: "Hb S O-Arab disease" EXACT []
synonym: "Hb S,O-Arab" EXACT []
synonym: "Hemoglobin S O-Arab Disease" EXACT []
synonym: "Sickle Cell-Haemoglobin O-Arab Disease" EXACT []
synonym: "Sickle Cell-Hemoglobin O-Arab Disease" EXACT []
synonym: "SO(Arab) disease" EXACT []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0000424 ! diagnosed using tool Electrophoresis
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000051 ! has causal genotype Hemoglobin Genotype S/O-Arab
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000040 ! has causal or contributing genetic variation HBB, GLU121LYS
relationship: SCDO:1000218 EUPATH:0000215 ! has manifestation Severe Anemia
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000016 ! has causal molecular phenotype Hemoglobin O-Arab
property_value: http://purl.org/dc/elements/1.1/source https://www.cancertherapyadvisor.com/labmed/anemia-associated-with-hemoglobin-s-o-arab/article/612377/
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-S-O-Arab xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001065
name: obsolete Sickle Cell-Hemoglobin Other than A,C,D,E,O-Arab
def: "'A variant of sickle cell disease in which individuals have atypical hemoglobin molecules called hemoglobin S together with another form of abnormal hemoglobin, other than hemoglobin C,D,E and O-Arab. [Curator team: []]'" []
synonym: "Hb S Other than A,C,D,E,O-Arab" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-S-and-other-than-A-C-D-E-O-Arab xsd:string
is_obsolete: true

[Term]
id: SCDO:0001067
name: Sickle Retinopathy
def: "Retinal changes of sickle cell disease that can be either proliferative or non-proliferative. In both cases, the changes are caused by erythrostasis secondary to sickling." []
synonym: "Retinopathy due to SCD" EXACT []
synonym: "Sickle Cell Retinopathy" EXACT []
is_a: HP:0000478 ! Abnormality of the Eye
is_a: NCIT:C115319 ! Ophthalmologic Complication
relationship: SCDO:1000202 SCDO:0008623 ! caused by Vaso-Occlusion
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "Request inclusion into HPO below \"Retinopathy\".\n\nUse the scielo source to add info on diagnosis and treatment." xsd:string
property_value: SCDO:0000340 "Bonanomi et al 2013 Arq Bras Oftalmol" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001068
name: Sickling Test
def: "A qualitative screening test for sickling haemoglobins, especially HbS. In the SCT, sodium metabisulfite or sodium dithionate is used to desolubilise haemoglobin S to the crystallised deoxygenated form, which causes the abnormal RBCs to sickle, as detected by light microscopy." []
synonym: "Sickle Cell Identification, Slide Method" EXACT []
is_a: SCDO:0000548 ! Hemoglobin S Test
is_a: SCDO:1000577 ! Type of SCD Test
property_value: SCDO:0000303 "In SNOMED CT this term seems to be both  \"Sickle cell identification, slide method\" and \"Sickling Test\". Request they merge these terms?" xsd:string
property_value: SCDO:0000340 "Segen's Medical Dictionary. © 2012 Farlex, Inc." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available." xsd:string

[Term]
id: SCDO:0001069
name: Sickness Impact Profile (SIP)
def: "A generic measure used to evaluate the impact of SCD on both physical and emotional functioning of an affected person. SIP is designed to measure perceived health status and to be used as an outcome measure for evaluation, program planning, and policy formation related to health care. It is designed in such a way as to reflect sensitivity to changes and/or differences in health status and to be applicable across a broad range of types and severities of the SCD illness, as well as different demographic and cultural groups." []
synonym: "Sickness Impact Profile" EXACT []
synonym: "SIP" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Bergner M., Bobbitt R.A., Carter W.B. and Gilson B.S. (1981). The Sickness Impact Profile: development and final revision of a health status measure. Medical Care 19,787-805." xsd:string
property_value: SCDO:0000303 "Too specific to SCD to be included in other ontologies.\n\nThese annotation properties still required: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations" xsd:string
property_value: SCDO:0000340 http://link.springer.com/referenceworkentry/10.1007%2F978-0-387-79948-3_1833 xsd:string
property_value: SCDO:0000340 http://qol.thoracic.org/sections/instruments/pt/pages/sick.html xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0001070
name: deprecated Skin
def: "'The bodily system consisting of the skin and its associated structures, such as the hair, nails, sweat glands, and sebaceous glands. [Curator team: []]'" []
synonym: "Dermatologic System" EXACT []
synonym: "Integumentary System" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 "integumentary system. (n.d.) The American Heritage Medical Dictionary. (2007). Retrieved December 14 2016" xsd:string
is_obsolete: true
replaced_by: SCDO:0008348

[Term]
id: SCDO:0001073
name: Skin Rash
def: "An abnormal change in skin color, appearance, or texture." []
synonym: "Exanthem" EXACT []
xref: HP:0000988
is_a: HP:0011122 ! Abnormality of Skin Physiology
relationship: SCDO:0000664 NCIT:C258 ! treated with Antibiotic
relationship: SCDO:0000664 SCDO:0000066 ! treated with Antihistamine
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Suggest update to description in HPO." xsd:string
property_value: SCDO:0000340 HP:0000988
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001075
name: Sleep Breathing Disorder
def: "An intrinsic sleep disorder characterized by breathing abnormalities." []
synonym: "SBD" EXACT []
xref: NBO:0000494
is_a: HP:0000708 ! Behavioural Abnormality
relationship: SCDO:0000663 SCDO:0001076 ! diagnosed using tool Sleep Disorders Screener - Adult
relationship: SCDO:0000663 SCDO:1000338 ! diagnosed using tool Sleep Disorders Screener - Children
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NBO_0000494 xsd:string
property_value: SCDO:1000288 "Suffcient" xsd:string

[Term]
id: SCDO:0001076
name: Sleep Disorders Screener - Adult
def: "An interviewer-administered questionnaire which captures routine sleep schedule, sleep deprivation, morningness-eveningness, insomnia, narcolepsy, cataplexy and associated distress." []
synonym: "National Institute of Mental Health (NIMH) Sleep Patterns and Problems Instrument" EXACT []
xref: phenX:121001
is_a: SCDO:1000348 ! Sleep Disorders Screener
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Suggest update to label\") as we have done." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/121001
property_value: SCDO:0000479 "PhenX protocol: Sleep Disorders Screener #121001" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001077
name: Slit Lamp
def: "A microscope with a light source that can be projected into a linear beam. It allows cross-sectional viewing of the aqueous humor; conjuncteiva; cornea; eyelids; iris; and lens of the eye." []
xref: MESH:D066167
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 NCIT:C75583 ! used by diagnostic tool Slit-Lamp Examination
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D066167 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001077 xsd:string

[Term]
id: SCDO:0001079
name: Smoking
def: "Inhaling and exhaling the smoke of burning tobacco (Cigar, Cigarette, Hookah, Pipe, Smoking, Waterpipe)." []
xref: MESH:D012907
is_a: SCDO:0000487 ! Health Behaviour
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012907 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001079 xsd:string

[Term]
id: SCDO:0001080
name: Smoking Cessation
def: "Discontinuing the habit of smoking." []
synonym: "Quit Smoking" EXACT []
xref: MESH:D016540
is_a: SCDO:0001159 ! Tobacco Use Cessation
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016540 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001080 xsd:string

[Term]
id: SCDO:0001082
name: Social Environment
def: "The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community." []
synonym: "Social Ecology" EXACT []
xref: MESH:D012931
is_a: SCDO:0000435 ! Environmental Disease Modifier
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012931 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001082 xsd:string

[Term]
id: SCDO:0001083
name: Social Functioning
def: "Social functioning defines an individual's interactions with their environment and the ability to fulfill their role within such environments as work, social activities, and relationships with partners and family." []
is_a: NCIT:C17047 ! Quality of Life
property_value: http://purl.org/dc/elements/1.1/source "PROMIS Domain Frameworks/Definitions nih.promis.org" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nInclude terms for social relationships; social activities?" xsd:string
property_value: SCDO:0000340 "Compr Psychiatry. 2000 Jan-Feb;41(1):63-9. Assessment of social functioning in depression." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001084
name: Social Isolation
def: "The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication." []
synonym: "Social Isolations" EXACT []
xref: MESH:D012934
is_a: SCDO:0001083 ! Social Functioning
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012934 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001084 xsd:string

[Term]
id: SCDO:0001085
name: Social Role
def: "A role that is ascribed to individuals in a community." []
synonym: "Social Function" EXACT []
xref: SIO:000676
is_a: SCDO:0001083 ! Social Functioning
property_value: SCDO:0000340 http://semanticscience.org/resource/SIO_000676 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001085 xsd:string

[Term]
id: SCDO:0001086
name: Social Role Fulfillment
def: "An extent/ degree to which an individual fulfills the expectations of his/her social role." []
is_a: SCDO:0001083 ! Social Functioning
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001087
name: Social Skill
def: "The personal set of abilities required to successfully interact and communicate with others, both verbally and non-verbally through gestures, body language and personal appearance." []
synonym: "Interpersonal Skill" EXACT []
synonym: "Social Ability" EXACT []
synonym: "Social Competence" EXACT []
synonym: "Social Skills" EXACT []
xref: MESH:D066107
is_a: SCDO:0001083 ! Social Functioning
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D066107 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001087 xsd:string

[Term]
id: SCDO:0001088
name: Social Support
def: "Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc." []
synonym: "Psychosocial Support System" EXACT []
synonym: "Social Network" EXACT []
xref: MESH:D012944
is_a: SCDO:0001083 ! Social Functioning
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012944 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001088 xsd:string

[Term]
id: SCDO:0001089
name: Social Values
def: "Abstract standards or empirical variables in social life which are believed to be important and/or desirable." []
synonym: "Value Orientation" EXACT []
synonym: "Value Orientations" EXACT []
xref: MESH:D012945
is_a: SCDO:0000299 ! Culture
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012945 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001089 xsd:string

[Term]
id: SCDO:0001090
name: Socioeconomic Factors
def: "Social and economic factors that characterize the individual or group within the social structure." []
xref: MESH:D012959
is_a: SCDO:0001082 ! Social Environment
property_value: SCDO:0000303 "Maybe include some sub-classes of this term in MESH? There would be overlap with terms in QOL, so would need to work around that." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012959 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001090 xsd:string

[Term]
id: SCDO:0001091
name: Socioeconomic Status
def: "The combination of one's social class and income level. Includes socioeconomic differences between individuals or groups." []
xref: APAONTO:Socioeconomic_Status
is_a: SCDO:0001090 ! Socioeconomic Factors
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/APAONTO/?p=classes&conceptid=http%3A%2F%2Fontology.apa.org%2Fapaonto%2FtermsonlyOUT%2520%285%29.owl%23Socioeconomic_Status xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001091 xsd:string

[Term]
id: SCDO:0001092
name: Solubility Test
def: "A basic first line test that looks for the presence of abnormal Hemoglobin S in a blood sample. Sodium metabisulfite is added to the blood sample which causes Hb S polymerisation and sickling of red blood cells if Hb S is present. A positive result means that a person has either Sickle Cell Disease or Sickle Cell Trait. Confirmatory tests are needed to distinguish which form of SCD the patient has." []
synonym: "Hemoglobin S Solubility Test" EXACT []
is_a: SCDO:0000548 ! Hemoglobin S Test
is_a: SCDO:1000577 ! Type of SCD Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "In SNOMED CT this term is \"Hemoglobin S Solubility Test\"\n\nCommonly used tests include hemoglobin electrophoresis, isoelectric focusing (IEF), high performance liquid chromatography (HPLC), and DNA analysis." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available." xsd:string

[Term]
id: SCDO:0001097
name: Sphygmomanometer
def: "Instruments for measuring arterial blood pressure consisting of an inflatable cuff, inflating bulb, and a gauge showing the blood pressure." []
xref: MESH:D019722
is_a: SCDO:0000710 ! Manometer
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D019722 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001097 xsd:string

[Term]
id: SCDO:0001098
name: Spirituality
def: "Sensitivity or attachment to religious values, or to things of the spirit as opposed to material or worldly interests." []
synonym: "Spiritual Beliefs" EXACT []
synonym: "Spiritualities" EXACT []
xref: MESH:D029181
is_a: SCDO:0000299 ! Culture
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D029181 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001098 xsd:string

[Term]
id: SCDO:0001099
name: Spirometer
def: "A spirometer is an apparatus for measuring the volume of air inspired and expired by the lungs. It is a precision differential pressure transducer for the measurements of respiration flow rates. The spirometer records the amount of air and the rate of air that is breathed in and out over a specified period of time." []
xref: ERO:0000452
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:0000474 SCDO:0000704 ! has output measurement Lung Volume Measurement
relationship: SCDO:1000191 NCIT:C85397 ! used by diagnostic tool Spirometry
relationship: SCDO:1000191 SCDO:0000705 ! used by diagnostic tool Lung Volume Test
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0000452 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001099 xsd:string

[Term]
id: SCDO:0001105
name: Steroid-Resistant Nephrotic Syndrome
def: "A form of nephrotic syndrome that does not respond to treatment with steroid medication after 8 weeks, specifically in children." []
xref: HP:0012588
is_a: SCDO:0000796 ! Nephrotic Syndrome
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1000219 SCDO:0000796 ! diagnosed by Nephrotic Syndrome
property_value: SCDO:0000303 "Suggest update to description in HPO\n\nProvide source for additional info." xsd:string
property_value: SCDO:0000340 HP:0012588
property_value: SCDO:0000661 "May represent underlying focal segmental glomerulosclerosis, minimal change disease, or other underlying cause.  Can be subseqeunt to known mutations." xsd:string
property_value: SCDO:0000662 "Persistence of nephrotic syndrome despite appropriate treatment with corticosteroids." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001107
name: Stigma
def: "A perceived attribute that is deeply discrediting and is considered to be a violation of social norms." []
synonym: "Social Stigma" EXACT []
synonym: "Social Stigmas" EXACT []
synonym: "Stigmas" EXACT []
xref: MESH:D057545
is_a: NCIT:C17047 ! Quality of Life
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D057545 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001107 xsd:string

[Term]
id: SCDO:0001108
name: Stigmatization
def: "An oversimplified perception or conception, especially or persons, social groups, etc." []
synonym: "Stereotyping" EXACT []
xref: MESH:D013240
is_a: NCIT:C17047 ! Quality of Life
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D013240 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001108 xsd:string

[Term]
id: SCDO:0001111
name: Stroke
def: "A group of pathological conditions characterized by sudden loss of neurological function due to brain ischemia or intracranial hemorrhages. Stroke is classified by the type of tissue necrosis, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature." []
synonym: "Brain Vascular Accident" EXACT []
synonym: "Cerebral Infarction" EXACT []
synonym: "Cerebral Vascular Event" EXACT []
synonym: "Cerebrovascular Accident" EXACT []
synonym: "Cerebrovascular Stroke" EXACT []
synonym: "CVA" EXACT []
xref: MESH:D020521
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
is_a: SCDO:1000037 ! Abnormality of the Cerebral Vasculature
relationship: SCDO:0000664 SCDO:0001166 ! treated with Transcranial Doppler Ultrasonography
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Types of stroke relevant to SCD to be added as children of this class." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D020521 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001111 xsd:string

[Term]
id: SCDO:0001112
name: Stroke Impact Measure
def: "This measure is a physical assessment to determine neurological deficits due to a stroke." []
synonym: "Stroke Impact/Outcome Measure" EXACT []
synonym: "Stroke Outcome Measure" EXACT []
xref: phenX:820800
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to label in PhenX" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX/?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F820800
property_value: SCDO:0000486 "This measure is used to describe the consequences of a stroke and to monitor the effects of treatment and recovery." xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001113
name: Stroke Impact Scale (SIS)
def: "This questionnaire includes 59 proxy- or self-report items in 8 domains that assess multidimensional stroke outcomes in adults." []
synonym: "Stroke Impact Scale (SIS) - Adults" EXACT []
xref: phenX:820701
is_a: SCDO:0001339 ! Functionality After Stroke Measure
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to description in PhenX." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820701 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Stroke Impact Scale (SIS) - Adults #820701" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001114
name: Stroke Risk Test in Children with Sickle Cell Disease
def: "A clinical test to measure the blood flow velocities in intracranial arteries. Elevated intracranial arterial blood flow rates are indicative of expanding vessel lesions and a subsequent increased risk of stroke." []
xref: phenX:821001
is_a: NCIT:C154865 ! Cerebral Blood Flow Assay
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000192 SCDO:0000396 ! uses diagnostic device Doppler Ultrasound Machine - 2 Megahertz
relationship: SCDO:1000194 NCIT:C173396 ! measures Cerebral Blood Flow Velocity
property_value: SCDO:0000303 "Include below \"Cerebral Flow Test\"? -- Include below \"Vascular Endothelial Function Test\"?" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/821001
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001114 xsd:string

[Term]
id: SCDO:0001117
name: Stuttering Priapism
def: "The occurrence of multiple self-limited episodes of unwanted, often painful erections lasting <4 hours." []
synonym: "Recurrent Priapism" EXACT []
is_a: SCDO:0000923 ! Priapism
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps below \"Priapism\" in MESH." xsd:string
property_value: SCDO:0000340 "Evidence-Based Management of Sickle Cell Disease, Expert Panel Report, 2014" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001120
name: Substance Use History
def: "Assessment with the goal to obtain a relevant drug and alcohol history and perform a physical examination in order to establish whether there is a diagnosis of a substance use disorder." []
comment: If substance use disorder diagnosed, the patient’s readiness to change should be categorized and information from the assessment should be used to formulate a management plan based on the individual’s needs.
is_a: NCIT:C18772 ! Personal Medical History
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0001121
name: Substances - Lifetime Use
def: "An indication of whether the respondent has ever used a drug during his or her entire life." []
is_a: SCDO:0001120 ! Substance Use History
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
relationship: SCDO:1000190 SCDO:1000337 ! obtained via diagnostic tool Substances - Lifetime Use Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0001122
name: Suicidal Thoughts
def: "Frequent thinking about or preoccupation with killing oneself." []
synonym: "Suicidal Ideation" EXACT []
xref: HP:0031589
is_a: SCDO:0000360 ! Depression
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Suggest update to description in HPO (correct typo in \"oneself\")" xsd:string
property_value: SCDO:0000340 HP:0031589
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001123
name: Support Group
def: "Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs." []
synonym: "Self Help Group" EXACT []
synonym: "Self-Help Group" EXACT []
synonym: "Self-Help Groups" EXACT []
synonym: "Therapeutic Social Club" EXACT []
xref: MESH:D012657
is_a: SCDO:0001083 ! Social Functioning
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012657 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001123 xsd:string

[Term]
id: SCDO:0001129
name: Supportive Therapeutics
def: "Measures aimed at providing appropriate supportive and rehabilitative services to minimize morbidity and maximize quality of life after a long-term disease or injury is present." []
synonym: "Supportive Therapy" EXACT []
synonym: "Tertiary Prevention" EXACT []
xref: MESH:D055512
is_a: SCDO:0001152 ! Therapeutics
relationship: SCDO:1000018 HP:0001919 ! treats Acute Kidney Injury
relationship: SCDO:1000018 HP:0002913 ! treats Myoglobinuria
relationship: SCDO:1000018 HP:0003198 ! treats Myopathy
relationship: SCDO:1000018 HP:0003641 ! treats Hemoglobinuria
relationship: SCDO:1000018 HP:0008682 ! treats Acute Tubular Necrosis
relationship: SCDO:1000018 HP:0009045 ! treats Exercise-Induced Rhabdomyolysis
relationship: SCDO:1000018 NCIT:C26702 ! treats Ataxia
relationship: SCDO:1000018 SCDO:0000032 ! treats Agenesis of Corpus Callosum
relationship: SCDO:1000018 SCDO:0000984 ! treats Renal Ischemia
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055512 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001129 xsd:string

[Term]
id: SCDO:0001132
name: Sustained and Selective Attention Diagnostic Instrument
def: "A computerized test for the assessment of visual attention problems in individuals ages 8 years old and older." []
synonym: "Conners Continuous Performance Test 3rd Edition" EXACT []
synonym: "Conners Continuous Performance Test 3rd Edition (Conners CPT 3)" EXACT []
synonym: "Conners CPT 3" EXACT []
xref: phenX:821201
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to label in PhenX as we have done." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=821201 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Sustained and Selective Attention #821201" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001133
name: Symptomatic Therapeutics
def: "Therapeutics that ease the symptoms without addressing the basic cause of the disease." []
synonym: "Symptomatic Treatment" EXACT []
is_a: SCDO:0001152 ! Therapeutics
relationship: SCDO:1000018 SCDO:0000021 ! treats Acute Upper Respiratory Tract Infection
relationship: SCDO:1000018 SCDO:0000032 ! treats Agenesis of Corpus Callosum
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.medicinenet.com/script/main/art.asp?articlekey=10701 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001135
name: Acute Sickle Cell Crisis
def: "Refers to a worsening, over a short period of time, of the symptoms and signs of SCD; usually associated with pain and/or shortage of blood (anaemia). Can be suspected in a person with sickle cell disease who presents with a sudden onset of pain, infection, anemia or other symptoms such as stroke or priapism. Acute pain frequently occurs spontaneously, but may be precipitated by infections, skin cooling, dehydration or stress." []
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:1000202 SCDO:0008623 ! caused by Vaso-Occlusion
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000303 "This is a difficult one to describe, as I think it can also be referred to as an 'acute painful crisis' (this is not clear from the literature). Have tried to merge descriptions from different sources - please review." xsd:string
property_value: SCDO:0000340 !scenario:1
property_value: SCDO:0000340 "Rees, D. C., Olujohungbe, A. D., Parker, N. E., Stephens, A. D., Telfer, P. and Wright, J. (2003), Guidelines for the management of the acute painful crisis in sickle cell disease. British Journal of Haematology, 120: 744-752. doi:10.1046/j.1365-2141.2003.04193.x" xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - Nigeria" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001136
name: deprecated Systemic
def: "'Affecting a number of tissues relating to the entire organism as distinguished from and of its individual parts. [Curator team: []]'" []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/systemic xsd:string
is_obsolete: true
replaced_by: SCDO:1000269

[Term]
id: SCDO:0001140
name: Tertiary Healthcare
def: "Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems." []
synonym: "Tertiary Care" EXACT []
synonym: "Tertiary Health Care" EXACT []
xref: MESH:D063128
is_a: SCDO:0000494 ! Health System
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D063128 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001140 xsd:string

[Term]
id: SCDO:0001141
name: Test of Functional Health Literacy in Adults (TOFHLA)
def: "The Test of Functional Health Literacy Assessment (TOFHLA) assesses a patient's level of comprehension of health-related material. It is available in a full-format (a 22-minute test, with 50 reading comprehension items in three passages and 17 numeracy items), an abbreviated format (a 12-minute test, with 36 reading comprehension items in two passages and four numeracy items) and a shortened version (the S-TOFHLA, a 7-minute test, with 36 reading comprehension items in 2 passages.). The passages on the S-TOFHLA use a modified Cloze procedure where every fifth to seventh word is omitted and subjects select the correct word from among a set of four options. The passages contain information about an upper gastrointestinal tract x-ray procedure, and the \"Rights and Responsibilities\" section from a Medicaid application, and have Gunning-Fox readability indices of fourth and tenth grade, respectively. In early developmental studies, the reading comprehension passages in the S-TOFHLA had a reliability coefficient (Cronbach's alpha) of 0.97 and correlation with the Rapid Estimate of Adult Literacy in Medicine (REALM) of 0.81. Each selection is scored a \"1\" for correct or a \"0\" for incorrect and scores are summed over items to create a total score. The 36-point scale of the S-TOFHLA is divided into three categories of functional literacy: inadequate (0-16), adequate (17-22) and functional (23-36)." []
synonym: "Test of Functional Health Literacy in Adults" EXACT []
synonym: "TOFHLA" EXACT []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: http://purl.org/dc/elements/1.1/source "Parker RM, Baker DW, Williams MV, Nurss JR. The test of functional health literacy in adults: a new instrument for measuring patients' literacy skills. Journal of General Internal Medicine. 1995;10(10):537-41." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\".\n\nStill must add these annotation properties: -- has respondents -- has target population -- selection criteria met -- validated for age ranges -- has cross-cultural adaptation -- freely available" xsd:string
property_value: SCDO:0000340 "Parker RM, Baker DW, Williams MV, Nurss JR. The test of functional health literacy in adults: a new instrument for measuring patients' literacy skills. Journal of General Internal Medicine. 1995;10(10):537-41." xsd:string
property_value: SCDO:0000484 "Spanish" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001146
name: The Duke Religion Index (DUREL)
def: "The Duke Religion Index (DUREL) is a five item scale which measures religiosity in three areas: organizational religiosity (OR), non-organizational religiosity (NOR), and intrinsic religiosity. Two of the questions were derived from large epidemiologic studies and have been shown to have a strong predictive value for many health outcomes. OR has been related to less depression, more social support, better physical health, lower resource utilization, and lower mortality. NOR has been shown to be related to poorer physical health, and greater social support. The other three items were taken from the Hoge 10- item religiosity scale (Hodge et al 1972). The DUREL has high test-retest reliability (intra-class correlation = 0.91), high internal consistency (Cronbach's alpha's = 0.78--0.91)." []
synonym: "DUREL" EXACT []
synonym: "The Duke Religion Index" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "Koenig, HG and Büssing A. (2010). The Duke University Religion Index (DUREL): A Five-Item Measure for Use in Epidemological Studies. Religions, 1, 78-85." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\".\n\nAlso requires these properties: -- has cross-cultural adaptation -- has translations" xsd:string
property_value: SCDO:0000340 "Koenig, HG and Büssing A. (2010). The Duke University Religion Index (DUREL): A Five-Item Measure for Use in Epidemological Studies. Religions, 1, 78-85." xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Adults with SCD" xsd:string
property_value: SCDO:0001033 "Used in at least one SCD study" xsd:string
property_value: SCDO:0001222 "Adults" xsd:string
property_value: SCDO:0001335 "no" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001150
name: Therapeutic Device
def: "A medical device used to prevent and treat medical conditions, or to alleviate pain or injury." []
is_a: SCDO:0001152 ! Therapeutics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0001151
name: Therapeutic Irrigation
def: "The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis." []
synonym: "Lavage" EXACT []
synonym: "Lavages" EXACT []
synonym: "Therapeutic Irrigations" EXACT []
xref: MESH:D007507
is_a: SCDO:0001129 ! Supportive Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007507 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001151 xsd:string

[Term]
id: SCDO:0001152
name: Therapeutics
def: "Procedures, agents or devices concerned with the remedial treatment or prevention of diseases." []
synonym: "Therapy" EXACT []
synonym: "Treatment" EXACT []
xref: MESH:D013812
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000303 "Chemotherapy to be added in this class? If so, would have to be specific types of chemotherapy relevant to the type of therapeutics class." xsd:string
property_value: SCDO:0000303 "Include as subclasses: -- Prosthesis -- Phototherapy (therapy for Jaundice) -- Risk Reduction? Copy relevant disease modifiers below this." xsd:string
property_value: SCDO:0000303 "Suggest update to description in MESH" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D013812
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001158
name: Indel Mutation
def: "A mutation named with the blend of insertion and deletion. It refers to a length difference between two alleles where it is unknowable if the difference was originally caused by a sequence insertion or by a sequence deletion. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a frameshift mutation." []
synonym: "Insertion-Deletion Mutation" EXACT []
xref: MESH:D054643
is_a: IDOMAL:50000026 ! Mutation
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D054643 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001158 xsd:string

[Term]
id: SCDO:0001159
name: Tobacco Use Cessation
def: "Ending the tobacco habits of smoking, chewing, or snuff use." []
synonym: "Tobacco Cessation" EXACT []
xref: MESH:D020340
is_a: SCDO:0000487 ! Health Behaviour
relationship: SCDO:1000018 HP:0002138 ! treats Subarachnoid Hemorrhage
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D020340 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001159 xsd:string

[Term]
id: SCDO:0001164
name: Traditional Healer
def: "A person who practices the art of healing using traditional medicine, a system of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (spiritual therapies); phytotherapy (plant therapy) and other treatments which may not be explained by modern medicine." []
synonym: "Faith Healer" EXACT []
synonym: "Folk Healer" EXACT []
synonym: "Healer" EXACT []
synonym: "Sangoma" EXACT []
synonym: "Shaman" EXACT []
is_a: SCDO:0000108 ! Beliefs About Remedies and Treatment
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/D008519
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps MESH." xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0001165
name: Trail Making Test
def: "An interviewer-administered, two-part test that requires the respondent to organize numerical and alphabetical sequences that are randomly distributed on a piece of paper. The protocol includes instructions for correcting mistakes and instructions for scoring based on speed and accuracy." []
synonym: "Executive Function - Adult" EXACT []
xref: phenX:131101
is_a: SCDO:0001304 ! Executive Function Measure
property_value: SCDO:0000303 "Suggest update to label in PhenX." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/131101
property_value: SCDO:0000479 "PhenX protocol: #131101" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001166
name: Transcranial Doppler Ultrasonography
def: "A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum." []
synonym: "TCD" EXACT []
synonym: "Transcranial Doppler" EXACT []
synonym: "Ultrasonography, Doppler, Transcranial" EXACT []
xref: MESH:D017585
is_a: NCIT:C154865 ! Cerebral Blood Flow Assay
is_a: NCIT:C17230 ! Ultrasound Test
is_a: SCDO:0001129 ! Supportive Therapeutics
relationship: SCDO:1000018 SCDO:0001111 ! treats Stroke
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017585 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001166 xsd:string

[Term]
id: SCDO:0001167
name: Transcutaneous Electrical Nerve Stimulation
def: "The use of specifically placed small electrodes to deliver electrical impulses across the skin to relieve pain. It is used less frequently to produce anesthesia." []
synonym: "Analgesic Cutaneous Electrostimulation" EXACT []
synonym: "Electroanalgesia" EXACT []
synonym: "Electroanalgesias" EXACT []
synonym: "Percutaneous Electrical Nerve Stimulation" EXACT []
synonym: "Percutaneous Electrical Neuromodulations" EXACT []
synonym: "Percutaneous Neuromodulation Therapies" EXACT []
synonym: "Percutaneous Neuromodulation Therapy" EXACT []
synonym: "TENS" EXACT []
synonym: "Transcutaneous Electric Stimulation" EXACT []
synonym: "Transcutaneous Electrical Stimulation" EXACT []
synonym: "Transcutaneous Nerve Stimulation" EXACT []
synonym: "Transdermal Electrostimulation" EXACT []
xref: MESH:D004561
is_a: SCDO:0000049 ! Analgesia
relationship: SCDO:1000018 SCDO:0000851 ! treats Pain
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004561 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001167 xsd:string

[Term]
id: SCDO:0001168
name: Transient Monocular Blindness
def: "Temporary loss of vision in one eye due to a lack of blood flow to the retina." []
synonym: "Amaurosis Fugax" EXACT []
synonym: "Temporary Blindness" EXACT []
synonym: "TMB" EXACT []
is_a: HP:0000618 ! Blindness
relationship: SCDO:0000663 NCIT:C38060 ! diagnosed using tool Eye Examination
relationship: SCDO:0000663 SCDO:0000133 ! diagnosed using tool Blood Test
relationship: SCDO:0000663 SCDO:0000417 ! diagnosed using tool Electrocardiography
relationship: SCDO:0000664 NCIT:C16567 ! treated with Exercise
relationship: SCDO:0000664 SCDO:0000497 ! treated with Healthy Diet
relationship: SCDO:0000664 SCDO:0000498 ! treated with Healthy Lifestyle
relationship: SCDO:0000664 SCDO:1000017 ! treated with Surgery
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/2261177
property_value: SCDO:0000303 "Request inclusion into HP below \"Blindness\"." xsd:string
property_value: SCDO:0000340 https://www.healthshare.com.au/factsheets/6399-amaurosis-fugax-transient-monocular-visual-loss/6520.pdf
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001197
name: obsolete Twin Study
def: "'Work consisting of reporting using a method of detecting genetic causes in human traits and genetic factors in behavior using sets of twins. [Curator team: []]'" []
xref: MESH:D018486
is_a: SCDO:0000941 ! obsolete Publication Type
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018486 xsd:string
is_obsolete: true

[Term]
id: SCDO:0001198
name: Twin Studies as Topic
def: "Works about methods of detecting genetic etiology in human traits. The basic premise of twin studies is that monozygotic twins carry identical genes, while zygotic twins are genetically no more similar than two siblings born after separate pregnancies. (Last, J.M., A Dictionary of Epidemiology, 2d ed)" []
xref: MESH:D018433
is_a: SCDO:0300004 ! Epidemiologic Study Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018433 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001198 xsd:string

[Term]
id: SCDO:0001200
name: UGT1A1
def: "This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome." []
synonym: "GNT1" EXACT []
synonym: "UDP Glucuronosyltransferase Family 1 Member A1" EXACT []
synonym: "UGT1" EXACT []
synonym: "UGT1A1 Gene" EXACT []
is_a: SCDO:0000810 ! Non-Globin Gene
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/gene/54658
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001204
name: Urban Location
def: "The region surrounding a city. Most inhabitants of urban areas have nonagricultural jobs. Urban areas are very developed, meaning there is a density of human structures such as houses, commercial buildings, roads, bridges, and railways." []
synonym: "Urban" EXACT []
synonym: "Urban Area" EXACT []
synonym: "Urban Environment" EXACT []
synonym: "Urban Setting" EXACT []
is_a: GAZ:00000448 ! Geographic Location
is_a: SCDO:0000496 ! Healthcare Access
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.nationalgeographic.org/encyclopedia/urban-area/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001205
name: Urinary Albumin Test
def: "A bioassay to measure urine concentration of albumin, which is produced by the liver and is the most abundant protein in the blood." []
comment: In the protocol provided, albumin concentration is measured according to a fluorescent immunoassay (FIA). The protocol also lists reference ranges for healthy adults.\n\nThe criteria for clinically significant proteinuria have been changed from an albumin-creatinine ratio (ACR) of 30 mg/mmol or more to 3 mg/mmol or more. This is because there is evidence that the risk of adverse outcomes is a continuum and starts at an ACR well below 30 mg/mmol.\n\nThe Sickle Cell Disease Research and Scientific Panel notes that the terms "microalbuminuria" and "macroalbuminuria" have been used clinically to describe different levels of abnormal albumin excretion rate: 30-299 mg/g urine creatinine, and >300 mg/gr urine creatinine, for microalbuminuria and macroalbuminuria, respectively. Recently, a new terminology has been proposed: "low level albuminuria" instead of microalbuminuia, and "high level albuminuria" for macroalbuminuria, since the older terminology could be interpreted as measuring different molecular forms of albumin. \n\nBecause albuminuria may be affected by non-pathological factors (exercise, menstruation contamination, biological variability, etc.), abnormal values should be confirmed within 1-2 months.
is_a: NCIT:C17241 ! Urine Test
is_a: SCDO:0000676 ! Kidney Function Test
relationship: SCDO:0001297 CMO:0000003 ! has essential measure Blood Pressure Measurement
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000567 ! has essential measure History of Kidney Failure Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000570 ! has essential measure History of Type I and Type 2 Diabetes Diagnostic Instrument
relationship: SCDO:1000194 SCDO:0001209 ! measures Urine Albumin Concentration
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: http://purl.org/dc/elements/1.1/source http://patient.info/doctor/microalbuminuria
property_value: SCDO:0000303 "Label different from source's \"Urinary Microalbumin - Assay\"" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/141501
property_value: SCDO:0000479 https://wwwn.cdc.gov/nchs/data/nhanes/2017-2018/labmethods/ALB-CR-J-MET-Urine-Albumin-508.pdf
property_value: SCDO:0000479 "PhenX protocol: Urinary Microalbumin Assay #141501" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001206
name: Urinary Creatinine Test
def: "A bioassay to measure urine concentration of creatinine, a muscle metabolite that is filtered out of blood by the kidneys." []
synonym: "Urinary Creatinine Assay" EXACT []
synonym: "Urine Creatinine Analysis" EXACT []
xref: phenX:141601
is_a: NCIT:C17241 ! Urine Test
is_a: SCDO:0000676 ! Kidney Function Test
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000194 SCDO:0001213 ! measures Urine Creatinine Concentration
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/141601
property_value: SCDO:0000479 https://wwwn.cdc.gov/nchs/data/nhanes/2017-2018/labmethods/ALB-CR-J-MET-Urine-Creatinine-508.pdf
property_value: SCDO:0000479 "PhenX protocol: Urinary Creatinine - Assay #141601" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001206 xsd:string

[Term]
id: SCDO:0001207
name: Urinary Protein Measurement
def: "Any measurement of protein present in urine." []
xref: CMO:0000770
is_a: CMO:0000256 ! Urine Measurement
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: SCDO:0000303 "Suggest update to description in CMO." xsd:string
property_value: SCDO:0000340 CMO:0000770
property_value: SCDO:1000288 "Suggest update to description (currently no description provided)." xsd:string

[Term]
id: SCDO:0001208
name: deprecated Urinary System
def: "The organs and passageways concerned with the production and excretion of urine, including the kidneys, ureters, urinary bladder, and urethra." []
xref: BTO:0003092
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/BTO_0003092 xsd:string
is_obsolete: true
replaced_by: SCDO:0001347

[Term]
id: SCDO:0001209
name: Urine Albumin Concentration
def: "The amount of albumin in a specified volume of urine." []
comment: Urine albumin levels which are above normal but not detectable with routine protein testing are referred to as low level albuminuria (the old term is microalbuminuria).\nBecause albuminuria may be affected by non-pathological factors (exercise, menstruation contamination, biological variability, etc.), abnormal values should be confirmed within 1-2 months.
synonym: "Urinary Albumin Concentration" EXACT []
synonym: "Urinary Albumin Level" EXACT []
synonym: "Urine Albumin Level" EXACT []
xref: CMO:0000130
is_a: SCDO:0001207 ! Urinary Protein Measurement
relationship: SCDO:0001297 CMO:0000003 ! has essential measure Blood Pressure Measurement
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:0001297 SCDO:0000567 ! has essential measure History of Kidney Failure Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000570 ! has essential measure History of Type I and Type 2 Diabetes Diagnostic Instrument
relationship: SCDO:1000190 SCDO:0001205 ! obtained via diagnostic tool Urinary Albumin Test
relationship: SCDO:1000772 HP:0012594 ! has possible finding Low Level Albuminuria
relationship: SCDO:1000772 SCDO:1000201 ! has possible finding High Level Albuminuria
relationship: SCDO:1000772 SCDO:1000836 ! has possible finding Normal Urine Albumin Concentration
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/141501
property_value: SCDO:0000303 "Suggest that the CMO removes the second part of the definition and puts as comment, as we have done. Also suggest the change to this second part." xsd:string
property_value: SCDO:0000340 CMO:0000130
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001210
name: Urine Albumin Excretion Rate
def: "The amount of albumin excreted into the urine within a specified period of time." []
comment: If the level of albumin in the urine is above normal but not high enough to be detectable with routine protein testing it is referred to as low level albuminuria (the old term is microalbuminuria).
synonym: "Urinary Albumin Excretion Rate" EXACT []
xref: CMO:0000757
is_a: SCDO:0001207 ! Urinary Protein Measurement
property_value: SCDO:0000303 "Suggest that the CMO removes the second part of the definition and puts as comment, as we have done. Also suggest the change to this second part." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000757 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001212
name: Urine Albumin-Creatinine Ratio
def: "A comparison of urine microalbumin, that is, a level of albumin in the urine which is above normal but not detectable with routine protein testing, to the amount of creatinine in a specified volume of urine. Often expressed as albumin concentration divided by creatinine concentration times 1000 mg per gram." []
synonym: "ACR" EXACT []
synonym: "ALBCREAT" EXACT []
synonym: "Albumin To Creatinine Protein Ratio Measurement" EXACT []
synonym: "Albumin-Creatinine Ratio" EXACT []
synonym: "Albumin/Creatinine Ratio" EXACT []
synonym: "Microalbumin/Creatinine Ratio" EXACT []
synonym: "UACR" EXACT []
synonym: "Urinary Albumin-Creatinine Ratio" EXACT []
synonym: "Urine Albumin Level to Urine Creatinine Level Ratio" EXACT []
synonym: "Urine Microalbumin-Creatinine Ratio" EXACT []
xref: CMO:0000384
is_a: SCDO:0001207 ! Urinary Protein Measurement
property_value: SCDO:0000303 "Suggest update to description as we have done." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CMO_0000384 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001213
name: Urine Creatinine Concentration
def: "The concentration of creatinine in a urine specimen." []
synonym: "Urinary Creatinine Concentration" EXACT []
synonym: "Urine Creatinine Amount" EXACT []
synonym: "Urine Creatinine Concentration Measurement Datum" EXACT []
synonym: "Urine Creatinine Level" EXACT []
is_a: CMO:0000256 ! Urine Measurement
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0001206 ! obtained via diagnostic tool Urinary Creatinine Test
relationship: SCDO:1000772 MP:0011470 ! has possible finding Increased Urine Creatinine Level
relationship: SCDO:1000772 MP:0011471 ! has possible finding Decreased Urine Creatinine Level
relationship: SCDO:1000772 SCDO:1000837 ! has possible finding Normal Urine Creatinine Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source ONSTR?p=classes&conceptid=http%3A%2F%2Fonstr.googlecode.com%2Fsvn%2Ftags%2FcurrentRelease%2F2014-09-03%2FONSTR.owl%23ONSTR:9965048
property_value: SCDO:0000303 "Request inclusion below \"urine creatinine measurement\" in the CMO." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001215
name: Urine Protein Sulfosalicylic Acid Precipitation Test
def: "A method in which sulfosalicylic acid (that is, the SSA reagent) is added to a small and equal volume of clear urine. The acidification causes precipitation of protein in the sample (seen as increasing turbidity), which can be subjectively quantitated visually or more precisely quantitated using photometry." []
synonym: "SSA Protein Precipitation Test" EXACT []
synonym: "Urine SSA Turbidimetry" EXACT []
synonym: "Urine Sulfosalicylic Acid Turbidimetry" EXACT []
synonym: "Urine Turbidimetry with Sulfosalicylic Acid" EXACT []
xref: MMO:0000504
is_a: SCDO:0000120 ! Biochemical Assay
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MMO_0000504 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001215 xsd:string

[Term]
id: SCDO:0001218
name: obsolete Urology
def: "The medical specialty concerned with the study, diagnosis, and treatment of diseases of the genitourinary tract." []
xref: NCIT:C17243
is_a: SCDO:0001208 ! deprecated Urinary System
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C17243 xsd:string
is_obsolete: true

[Term]
id: SCDO:0001223
name: Validation Studies
def: "Works consisting of research using processes by which the reliability and relevance of a procedure for a specific purpose are established." []
xref: MESH:D023361
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D023361 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001223 xsd:string

[Term]
id: SCDO:0001224
name: Vaping
def: "Smoking vapors produced from electronic nicotene delivery systems." []
synonym: "Electronic Cigarrete Use" EXACT []
xref: MESH:D000072137
is_a: SCDO:0001079 ! Smoking
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000072137 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001224 xsd:string

[Term]
id: SCDO:0001228
name: Endothelial Function Test
def: "A measure of vascular endothelial cell response to stimulation, for example, by vasoactive substances released by or those that interact with the vascular endothelium." []
synonym: "Assessment of Endothelial Cell Function" EXACT []
synonym: "Endothelium Dysfunction Test" EXACT []
synonym: "Vascular Endothelial Function Test" EXACT []
is_a: SCDO:0000902 ! Physiological Assay
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://circ.ahajournals.org/content/108/17/2054 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001229
name: Vaso-Occlusive Crisis
def: "Pain resulting from tissue ischemia as a result of blockage of blood vessels, occurring in a variety of vascular beds, but most commonly in the bone or bone marrow and requiring analgesic medication." []
synonym: "Acute Pain Crisis" EXACT []
synonym: "Sickle Crisis" EXACT []
synonym: "Vaso-Occlusive Crisis" EXACT []
synonym: "Vaso-Occlusive Episodes" EXACT []
synonym: "VOC" EXACT []
is_a: SCDO:0001023 ! SCD Related Pain
relationship: SCDO:1000202 SCDO:0008623 ! caused by Vaso-Occlusion
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Evidence-Based Management of Sickle Cell Disease:  Expert Panel Report (EPR), 2014" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0001230
name: Venipuncture
def: "Extraction of blood from a vein using a needle. In human, the basilic, cephalic and median cubital veins are most commonly used as well as the femoral vein." []
xref: MMO:0000090
is_a: SCDO:0000082 ! Diagnostic Technique, Method, Test or Assay
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/MMO_0000090 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001230 xsd:string

[Term]
id: SCDO:0001232
name: Vineland Adaptive Behavior Scales, Second Edition (Vineland-II)
def: "A parent or caregiver questionnaire administered as part of a structured interview that measures day-to-day performance on communication, daily living, socialization, and motor skills. Standard scores can be derived for communication, daily living, socialization, and motor skills subtests or combined to create an Adaptive Behavior Composite (ABC)." []
synonym: "VABS" EXACT []
synonym: "Vineland Adaptive Behavior Scales" EXACT []
synonym: "Vineland-II" EXACT []
xref: phenX:820601
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to label in PhenX as we have done." xsd:string
property_value: SCDO:0000340 http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820601 xsd:string
property_value: SCDO:0000479 "PhenX protocol: Adaptive Behavior/Adaptive Function #820601" xsd:string
property_value: SCDO:0000481 "Proxy" xsd:string
property_value: SCDO:0000486 "This measure can be used to identify individuals with developmental disabilities or delays, perform diagnostic evaluations, monitor progress, and develop programs." xsd:string
property_value: SCDO:0001222 "All ages from birth through age 90" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001234
name: Virus
def: "Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells." []
synonym: "Viruses" EXACT []
xref: MESH:D014780
is_a: OBI:0000925 ! Infectious Agent
property_value: SCDO:0000303 "Add sub-classes:\nHepatitis C Virus (term in NCIT)\nHepatitis B Virus (term not found in other ontologies)" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D014780 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001234 xsd:string

[Term]
id: SCDO:0001237
name: Vitrectomy
def: "Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma." []
synonym: "Vitrectomies" EXACT []
xref: MESH:D014821
is_a: SCDO:0000833 ! Ophthalmologic Surgical Procedure
relationship: SCDO:1000018 HP:0007902 ! treats Vitreous Hemorrhage
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D014821 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001237 xsd:string

[Term]
id: SCDO:0001240
name: Western Blot
def: "Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes." []
synonym: "Western Immunoblot" EXACT []
xref: MESH:D015153
is_a: SCDO:0000424 ! Electrophoresis
property_value: SCDO:0000303 "Can this term also be below \"Immunological Assay\"?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D015153
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001240 xsd:string

[Term]
id: SCDO:0001241
name: Wheezing Episode with Co-Morbid Asthma
def: "An acute onset of wheezing in a person with SCD and co-morbid asthma." []
synonym: "Asthma Attack" EXACT []
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C18772 ! diagnosed using tool Personal Medical History
relationship: SCDO:0000663 SCDO:0000166 ! diagnosed using tool Bronchodilator Responsiveness Test
relationship: SCDO:0000663 SCDO:0000898 ! diagnosed using tool Physical Examination
relationship: SCDO:0000663 SCDO:0000942 ! diagnosed using tool Pulmonary Function Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Glassberg, Jeffrey A., Robert Strunk, and Michael R. DeBaun. “Wheezing in Children with Sickle Cell Disease.” Current opinion in pediatrics 26.1 (2014): 9–18. PMC. Web. 2 Aug. 2017." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Paediatr Respir Rev. 2014 Mar;15(1):13-6. doi: 10.1016/j.prrv.2013.10.005. Epub 2013 Oct 31." xsd:string
property_value: SCDO:0000340 "Glassberg, Jeffrey A., Robert Strunk, and Michael R. DeBaun. “Wheezing in Children with Sickle Cell Disease.” Current opinion in pediatrics 26.1 (2014): 9–18. PMC. Web. 2 Aug. 2017." xsd:string
property_value: SCDO:0000340 "Paediatr Respir Rev. 2014 Mar;15(1):13-6. doi: 10.1016/j.prrv.2013.10.005. Epub 2013 Oct 31." xsd:string
property_value: SCDO:0000661 "Synergistic inflammatory response due to both SCD and asthma." xsd:string
property_value: SCDO:0000662 "Increased severity of episodes." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001246
name: Witchcraft
def: "An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3rd Ed)." []
synonym: "Sorceries" EXACT []
synonym: "Sorcery" EXACT []
xref: MESH:D018599
is_a: SCDO:0000107 ! Beliefs About Causes of Illness
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018599 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001246 xsd:string

[Term]
id: SCDO:0001247
name: World Health Organisation Quality of Life Instrument (WHOQOL)
def: "The WHOQOL is a quality of life assessment developed by the WHOQOL Group with fifteen international field centres, simultaneously, in an attempt to develop a quality of life assessment that would be applicable cross-culturally." []
synonym: "WHOQOL" EXACT []
synonym: "World Health Organisation Quality of Life Instrument" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "WHOQOL Group (1993). Measuring quality of life: The development of the World Health Organisation quality of life instrument (WHOQOL). Geneva: WHO." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\".\n\nStill must add these annotation properties: -- validated for age ranges -- has cross-cultural adaptation -- freely available -- has translations" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Healthy people; Clinic patients" xsd:string
property_value: SCDO:0001033 "Demonstrated validity with SCD populations; at least two publications using the measure" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001249
name: X-Ray Image
def: "The visual output that an X-ray machine produces." []
is_a: SCDO:1000313 ! Diagnostic Device Visual Output
relationship: SCDO:1000190 SCDO:0000963 ! obtained via diagnostic tool Radiography
relationship: SCDO:1000193 OBI:0001138 ! output of diagnostic device X-Ray Machine
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0001250
name: X-Ray Image of Chest
def: "The visual output that an X-ray machine produces when imaging the chest." []
synonym: "Chest X-Ray Image" EXACT []
is_a: SCDO:0001249 ! X-Ray Image
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0000217 ! obtained via diagnostic tool Chest X-Ray
relationship: SCDO:1000193 OBI:0001138 ! output of diagnostic device X-Ray Machine
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0001252
name: X-Ray Therapy
def: "Medical treatment involving the use of controlled amounts of X-Rays." []
synonym: "Roentgenotherapy" EXACT []
synonym: "X Ray Therapy" EXACT []
synonym: "X-ray Beam Therapy" EXACT []
synonym: "Xray Therapy" EXACT []
xref: MESH:D014964
is_a: SCDO:0001129 ! Supportive Therapeutics
relationship: SCDO:1000018 OBI:1110053 ! treats Cancer
property_value: http://purl.org/dc/elements/1.1/source http://www.freethesaurus.com/x-ray+therapy
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D014964 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001252 xsd:string

[Term]
id: SCDO:0001253
name: X-Rays
def: "Penetrating, high-energy electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the gamma rays wavelength range. The distinction between gamma rays and X-rays is based on their radiation source." []
synonym: "X-Radiation" EXACT []
synonym: "X-Ray Electromagnetic Radiation" EXACT []
xref: MESH:D014965
is_a: OBI:0001138 ! X-Ray Machine
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "This should probably be removed." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D014965 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001253 xsd:string

[Term]
id: SCDO:0001267
name: EuroQol Five Dimensions Questionnaire (EQ-5D)
def: "The EQ-5D is a widely-used generic instrument for describing health-related quality of life states in five dimensions scored from 1 to 3 or 1 to 5, and a visual analogue scale to record self-rated health state from 0 to100. These provide a simple descriptive profile and a single index value for health status. The EQ-5D can also be used to calculate health utilities and determine the quality-adjusted life years associated with a health state. There is also a youth version (EQ-5D-Y)." []
synonym: "EQ-5D" EXACT []
synonym: "European Quality of Life Five Dimension Five Level Scale Questionnaire" EXACT []
synonym: "EuroQol Five Dimension Self-Report Questionnaire" EXACT []
synonym: "EuroQol Five Dimensions Questionnaire" EXACT []
synonym: "EuroQol Five-Dimensional Questionnaire" EXACT []
is_a: SCDO:0000951 ! Quality of Life and Care Measure
property_value: http://purl.org/dc/elements/1.1/source "Anie KA, Grocott H, White L, Dzingina M, Rogers G, Cho G (2012).  Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease. BMJ Open, 2, e001274. doi:10.1136/bmjopen-2012-001274." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Howard, J, Malfroy, M, Llewelyn, C et al. The Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trial. Lancet. 2013; 381(9870):930–938." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "The EuroQol Group. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy. 1990; 16(3):199-208." xsd:string
property_value: SCDO:0000340 "The EuroQol Group. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy. 1990; 16(3):199-208." xsd:string
property_value: SCDO:0000470 "Multiple countries and cultural groups" xsd:string
property_value: SCDO:0000481 "Self" xsd:string
property_value: SCDO:0000482 "Healthy People; Clinic Patients" xsd:string
property_value: SCDO:0001033 "Widely used around the world, also used in SCD" xsd:string
property_value: SCDO:0001222 "Adults and Youth (8 to 18 years)" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0001268
name: Functional Assessment of Chronic Illness Therapy-Spirituality (FACIT-Sp) Scale
def: "The FACIT-Sp is a 12-item measure that asks participants to indicate how true various statements are about them on a Likert scale of 0 (\"not at all\") to 4 (\"very much\"). Responses on the FACIT-Sp are summed to create a total score, ranging from 0 to 48, with higher scores representing higher levels of spirituality." []
synonym: "FACIT-Sp Scale" EXACT []
synonym: "Functional Assessment of Chronic Illness Therapy-Spirituality Scale" EXACT []
is_a: SCDO:0000953 ! Quality of Life Measure
property_value: http://purl.org/dc/elements/1.1/source "Peterman AH, Fitchett G, Brady MJ, et al. Measuring spiritual well-being in people with cancer: the functional assessment of chronic illness therapy—Spiritual Well-being Scale (FACIT- Sp). Ann Behav Med. 2002;24:49–58." xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Research or Clinical Assessment Tool\"." xsd:string
property_value: SCDO:0000340 "Peterman AH, Fitchett G, Brady MJ, et al. Measuring spiritual well-being in people with cancer: the functional assessment of chronic illness therapy—Spiritual Well-being Scale (FACIT- Sp). Ann Behav Med. 2002;24:49–58." xsd:string
property_value: SCDO:0000481 "Self; Proxy (Parent report)" xsd:string
property_value: SCDO:0000482 "Children with SCD and their parents" xsd:string
property_value: SCDO:0001033 "Demonstrated validity in SCD studies." xsd:string
property_value: SCDO:0001222 "Children and adults" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001284
name: Behaviour Therapy
def: "The application of modern theories of learning and conditioning in the treatment of behavior disorders." []
synonym: "Behavior Modification" EXACT []
synonym: "Behavior Modifications" EXACT []
synonym: "Behavior Therapies" EXACT []
synonym: "Behavior Therapy" EXACT []
synonym: "Conditioning Therapies" EXACT []
synonym: "Conditioning Therapy" EXACT []
xref: MESH:D001521
is_a: SCDO:0000940 ! Psychotherapy
relationship: SCDO:1000015 SCDO:0000106 ! modifies Behaviour
relationship: SCDO:1000018 HP:0001513 ! treats Obesity
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001521 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001284 xsd:string

[Term]
id: SCDO:0001288
name: Cluster Headache
def: "A primary headache disorder that is characterized by severe, strictly unilateral pain which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial sweating, eyelid edema, and miosis." []
synonym: "Acute Severe Headache" EXACT []
synonym: "Cluster Headaches" EXACT []
synonym: "Migraine, Neuralgic" EXACT []
xref: MESH:D003027
is_a: HP:0012638 ! Abnormal Nervous System Physiology
is_a: SCDO:0000851 ! Pain
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:0000663 OGMS:0000088 ! diagnosed using tool Patient Symptom Report
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003027 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001288 xsd:string

[Term]
id: SCDO:0001292
name: D57.00 Hb-SS disease with crisis, unspecified
def: "Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis." []
synonym: "D57.00" EXACT []
synonym: "Hb-SS disease with (painful) crisis NOS" EXACT []
synonym: "Hb-SS disease with crisis, unspecified" EXACT []
synonym: "Hb-SS disease with vasoocclusive pain NOS" EXACT []
synonym: "Hemoglobin S sickling disorder with crisis" EXACT []
synonym: "Sickle cell anemia, crisis" EXACT []
xref: ICD10CM:D57.00
is_a: SCDO:0000312 ! D57.0 Hb-SS disease with crisis
relationship: SCDO:1000785 NCIT:C131682 ! code requires phenotype Sickle Cell Disease-SS
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.00 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001292 xsd:string

[Term]
id: SCDO:0001295
name: Electrocardiograph
def: "An instrument used in the detection and diagnosis of heart abnormalities that measures electrical potentials on the body surface and generates a record of the electrical currents associated with heart muscle activity." []
synonym: "Cardiograph" EXACT []
synonym: "Electrocardiographic Instrument" EXACT []
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 SCDO:0000417 ! used by diagnostic tool Electrocardiography
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://en.wiktionary.org/wiki/electrocardiograph xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0001296
name: Erythrocyte Transfusion
def: "The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor." []
synonym: "Erythrocyte Transfusions" EXACT []
synonym: "Red Blood Cell Transfusion" EXACT []
synonym: "Red Blood Cell Transfusions" EXACT []
synonym: "Transfusion, Erythrocyte" EXACT []
synonym: "Transfusions, Erythrocyte" EXACT []
xref: MESH:D017707
is_a: SCDO:0000138 ! Blood Component Transfusion
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017707 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001296 xsd:string

[Term]
id: SCDO:0001299
name: Evaluation Studies
def: "Works consisting of studies determining the effectiveness or utility of processes, personnel, and equipment." []
xref: MESH:D023362
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D023362 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001299 xsd:string

[Term]
id: SCDO:0001303
name: Exchange Transfusion, Whole Blood
def: "Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria." []
synonym: "Exchange Blood Transfusion" EXACT []
xref: MESH:D005078
is_a: SCDO:0000147 ! Blood Transfusion
relationship: SCDO:1000018 HP:0001789 ! treats Hydrops Fetalis
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005078
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001303 xsd:string

[Term]
id: SCDO:0001304
name: Executive Function Measure
def: "An interviewer-administered test to measure a respondent's system of high-level cognitive functions such as abstract thinking, rule acquisition, cognitive flexibility, and goal-oriented behavior." []
xref: phenX:131100
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/phenX/131100
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001304 xsd:string

[Term]
id: SCDO:0001312
name: deprecated Eye
def: "The organ of vision that consists of the eyeball and the optic nerve." []
synonym: "Oculus" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/eye xsd:string
is_obsolete: true
replaced_by: SCDO:1000294

[Term]
id: SCDO:0001316
name: obsolete Facial Paralysis
def: "Facial paralysis is loss of facial movement because of nerve damage." []
xref: DOID:13934
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "Is this not the same thing as \"Facial Nerve Palsy\"?" xsd:string
is_obsolete: true
replaced_by: SCDO:0001315

[Term]
id: SCDO:0001319
name: Fatigue
def: "Inability to function due to tiredness related to sickle cell disease." []
synonym: "Fatigability" EXACT []
synonym: "Fatigable" EXACT []
synonym: "Lassitude" EXACT []
synonym: "Tiredness" EXACT []
is_a: HP:0025142 ! Constitutional Symptom
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Use the literature cited here to link to other phenotypes." xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string
property_value: seeAlso http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076611/

[Term]
id: SCDO:0001320
name: Feasibility Studies
def: "Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project." []
xref: MESH:D005240
is_a: SCDO:0300004 ! Epidemiologic Study Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005240 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001320 xsd:string

[Term]
id: SCDO:0001321
name: Fentanyl
def: "A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance." []
synonym: "Duragesic" EXACT []
synonym: "Durogesic" EXACT []
synonym: "N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide" EXACT []
synonym: "Phentanyl" EXACT []
xref: MESH:D005283
is_a: CHEBI:35482 ! Opioid
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Were these specific synonyms selected form the long list in the description source because of specific relevance to SCD?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005283
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001321 xsd:string

[Term]
id: SCDO:0001322
name: Serum Ferritin Test
def: "A bioassay to measure the serum concentration of ferritin (i.e., iron)." []
synonym: "Ferritin Blood Test" EXACT []
synonym: "Ferritin Measurement" EXACT []
synonym: "Plasma Ferritin Assay" EXACT []
synonym: "Plasma Ferritin Test" EXACT []
synonym: "Serum Ferritin Assay" EXACT []
xref: phenX:811301
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000194 SCDO:0001323 ! measures Serum Ferritin Level
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Serum or Plasma Ferritin\")" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/811301
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:0001323
name: Serum Ferritin Level
def: "The amount of ferritin found in a specified volume of serum." []
synonym: "Blood Serum Ferritin Concentration" EXACT []
synonym: "Blood Serum Ferritin Concentration Measurement Datum" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:0001297 NCIT:C16564 ! has essential measure Ethnic Group
relationship: SCDO:0001297 NCIT:C17049 ! has essential measure Race
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000190 SCDO:0001322 ! obtained via diagnostic tool Serum Ferritin Test
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Suggest update to description and label of \"ferritin measurement\" in the EFO." xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001325
name: Flow Cytometer
def: "An instrument which is used to count and sort microscopic particles suspended in a buffer. This instrument consists of a flow cell, at least one lamp or laser, a variable number of emission detectors or photomultipliers, a system that converts analog signals to digital, and a computer to run the system and collect and analyze the data output." []
xref: NPO:1769
is_a: SCDO:0000376 ! Diagnostic Device
relationship: SCDO:1000191 SCDO:0001326 ! used by diagnostic tool Flow Cytometry
property_value: SCDO:0000303 "Not sure whether this can be classified as a \"Medical Device\"." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/npo#NPO_1769 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001325 xsd:string

[Term]
id: SCDO:0001326
name: Flow Cytometry
def: "Flow cytometry uses the principles of light scattering and fluorescence from fluorochrome molecules to generate specific multi-parameter data from particles and cells in the size range of 0.5um to 40um diameter." []
xref: BAO:0000005
is_a: SCDO:0000896 ! Physical Detection Method
relationship: SCDO:1000192 SCDO:0001325 ! uses diagnostic device Flow Cytometer
relationship: SCDO:1000194 SCDO:0000975 ! measures Red Blood Cell Microparticles Level
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/BAO/?p=classes&conceptid=http%3A%2F%2Fwww.bioassayontology.org%2Fbao%23BAO_0000005&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001326 xsd:string

[Term]
id: SCDO:0001327
name: Fluorescein Angiography
def: "Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature." []
synonym: "Fluorescence Angiography" EXACT []
xref: MESH:D005451
is_a: OBI:0000185 ! Imaging Assay
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005451 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001327 xsd:string

[Term]
id: SCDO:0001328
name: Focal Dystonia
def: "A rare neurologic movement disorder characterized by sustained muscle contractions of a single body region, usually producing twisting and repetitive movements or abnormal postures or positions." []
xref: ORPHA:1866
is_a: HP:0012638 ! Abnormal Nervous System Physiology
property_value: SCDO:0000340 Orphanet:1866
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001328 xsd:string

[Term]
id: SCDO:0001329
name: Folic Acid
def: "A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia." []
synonym: "Folacin" EXACT []
synonym: "Folate" EXACT []
synonym: "Folvite" EXACT []
synonym: "L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-" EXACT []
synonym: "Pteroylglutamic Acid" EXACT []
synonym: "Vitamin B9" EXACT []
synonym: "Vitamin M" EXACT []
xref: MESH:D005492
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0000922 ! Preventative Therapeutics
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1000018 SCDO:0000115 ! treats Beta Zero Thalassemia
relationship: SCDO:1000018 SCDO:0000519 ! treats Hemoglobin C Disease
relationship: SCDO:1000018 SCDO:0000530 ! treats Hemoglobin E Disease
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005492
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001329 xsd:string

[Term]
id: SCDO:0001330
name: Follow-Up Studies
def: "Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease." []
synonym: "Follow Up Studies" EXACT []
synonym: "Follow-Up Study" EXACT []
synonym: "Followup Studies" EXACT []
xref: MESH:D005500
is_a: SCDO:0000263 ! Cohort Studies
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005500 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001330 xsd:string

[Term]
id: SCDO:0001334
name: Chronic Phenotype
def: "An observable characteristic of disease that is persistent and long standing." []
xref: NCIT:C14141
xref: SIO:010056
is_a: HP:0000118 ! Abnormal Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C14141 xsd:string
property_value: SCDO:0000340 http://semanticscience.org/resource/SIO_010056 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001336
name: from phenotype
def: "Terms deprecated in the \"Phenotype\" class." []
is_a: SCDO:0000359 ! deprecated terms

[Term]
id: SCDO:0001339
name: Functionality After Stroke Measure
def: "A questionnaire to measure the health status of individuals who had a stroke." []
synonym: "Functionality After Stroke Diagnostic Instrument" EXACT []
xref: phenX:820700
is_a: SCDO:0000953 ! Quality of Life Measure
is_a: SCDO:1000297 ! Quality of Life and Care Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F820700
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001339 xsd:string

[Term]
id: SCDO:0001340
name: deprecated Gastrointestinal System
def: "'The system concerned with the function and disorders of the gastrointestinal tract, including stomach, intestines, and associated organs including liver, pancreas and gall bladder. [Curator team: []]'" []
synonym: "gastrointestinal tract" EXACT []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://medical-dictionary.thefreedictionary.com/gastroenterology xsd:string
is_obsolete: true
replaced_by: SCDO:0000335

[Term]
id: SCDO:0001342
name: Gene-Environment Interaction
def: "Combined effects of genotypes and environmental factors together to affect phenotypic characteristics." []
xref: MESH:D059647
is_a: SCDO:0000391 ! Disease Modifier
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D059647 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001342 xsd:string

[Term]
id: SCDO:0001369
name: Genetic Variation
def: "Deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents." []
xref: NCIT:C17248
is_a: SCDO:0000765 ! Genetic Phenomena
relationship: SCDO:1000015 OGMS:0000023 ! modifies Phenotype
property_value: SCDO:0000303 "Suggest update to description in NCIT" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C17248 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001373
name: deprecated beta C mutation
def: "'To be defined by an expert [Curator team: []]'" []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "made a synonym of HBB, GLU6LYS" xsd:string
is_obsolete: true
replaced_by: SCDO:1000041

[Term]
id: SCDO:0001374
name: obsolete heterozygous beta c mutation
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true

[Term]
id: SCDO:0001375
name: obsolete homozygous beta c mutation
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true

[Term]
id: SCDO:0001376
name: deprecated beta E mutation
def: "'To be defined by an expert [Curator team: []]'" []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "Made a synonym of \"HBB, GLU26LYS\"" xsd:string
is_obsolete: true
replaced_by: SCDO:1000042

[Term]
id: SCDO:0001377
name: deprecated beta S mutation
def: "'To be defined by an expert [Curator team: []]'" []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "Made a synonym of HBB, GLU6VAL" xsd:string
is_obsolete: true
replaced_by: SCDO:1000039

[Term]
id: SCDO:0001378
name: HBA1
def: "This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA2." []
synonym: "HBA1 Gene" EXACT []
synonym: "Hemoglobin Subunit Alpha 1 Gene" EXACT []
synonym: "Hemoglobin, Alpha 1 Gene" EXACT []
xref: NCIT:C75429
is_a: SCDO:1000361 ! Alpha-Globin Gene
property_value: SCDO:0000303 "Suggest update to description in NCIT." xsd:string
property_value: SCDO:0000340 http://www.ontobee.org/ontology/NCIT?iri=http://purl.obolibrary.org/obo/NCIT_C75429 xsd:string
property_value: SCDO:0000340 "synonyms"
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001379
name: HBA2
def: "This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA1." []
synonym: "HBA2 Gene" EXACT []
synonym: "Hemoglobin Subunit Alpha 2 Gene" EXACT []
synonym: "Hemoglobin, Alpha 2 Gene" EXACT []
is_a: SCDO:1000361 ! Alpha-Globin Gene
property_value: SCDO:0000303 "Suggest update to description in NCIT." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C75432 xsd:string
property_value: SCDO:0000340 "synonyms"
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001382
name: Hemoglobin Subunit Gamma
def: "Gamma Globin is a type of polypeptide chain that when in combination with alpha globin chains forms fetal hemoglobin. Beta-Hemoglobin subunits gamma-1 (147 aa, ~16 kDa) and gamma-2 (147 aa, ~16 kDa) are encoded by the human HBG1 and HBG2 gene respectively, in the beta-globin gene cluster. These proteins play a role in the transport of oxygen to tissues of the fetal body." []
synonym: "Gamma-Globin" EXACT []
synonym: "Haemoglobin Gamma Chain" EXACT []
synonym: "Haemoglobin Subunit Gamma" EXACT []
synonym: "Hemoglobin Gamma Chain" EXACT []
is_a: SCDO:1000012 ! Beta-Globin Family Members
property_value: http://purl.org/dc/elements/1.1/source http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C84982
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 https://www.genecards.org/cgi-bin/carddisp.pl?gene=HBG1 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001384
name: Reduced Alpha/Gamma Synthesis Ratio
def: "A reduction in the ratio of production of alpha globin to that of gamma globin." []
synonym: "Increased Gamma/Alpha Synthesis Ratio" EXACT []
is_a: HP:0005560 ! Imbalanced Hemoglobin Synthesis
relationship: SCDO:1000210 SCDO:0001386 ! has causal or contributing genetic variation Alpha-Globin Locus Deletion
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Nicole Vasilevsky)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO below \"Imbalanced Hemoglobin Synthesis\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001385
name: Absence of Alpha Globin Synthesis with Gamma Globin Synthesis
def: "The state, in utero or shortly after birth, in which all four alpha globin genes are deleted or inactivated resulting in absent alpha globin synthesis. If gamma globin synthesis persists, then the resulting phenotype is hemoglobin Barts (four gamma chains) and hemoglobin Bart hydrops fetalis." []
is_a: SCDO:0001384 ! Reduced Alpha/Gamma Synthesis Ratio
relationship: SCDO:1000210 SCDO:0001387 ! has causal or contributing genetic variation Homozygous Deletion of HBA1 and HBA2
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into HPO below \"Reduced Alpha/Gamma Synthesis Ratio\" (also requested for inclusion)." xsd:string
property_value: SCDO:0000340 "Marengo-Rowe, A.J., 2007, January. The thalassemias and related disorders. In Baylor university medical center proceedings (Vol. 20, No. 1, pp. 27-31). Taylor & Francis." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001386
name: Alpha-Globin Locus Deletion
def: "A deletion in or of the HBA1 or HBA2 gene that can result in some form of alpha thalassemia." []
synonym: "Alpha-Globin Cluster Deletion" EXACT []
synonym: "Alpha-Globin Gene Cluster Deletion" EXACT []
synonym: "HBA Locus Deletion" EXACT []
is_a: NCIT:C19296 ! Deletion Mutation
relationship: SCDO:1000015 SCDO:0000251 ! modifies Clinical Phenotype of Beta Thalassemia
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000303 "Still need to add one sub-class:\nthe complete deletion of the HBA1 and HBA2 genes on one chromosome 16, combined with a defect (deletional or nondeletional) in either the HBA1 or HBA2 gene on the other chromosome 16, leaving one functioning gene present (https://www.snpedia.com/index.php/Alpha_Thalassemia)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001387
name: Homozygous Deletion of HBA1 and HBA2
def: "Deletion of all four alpha-globin genes resulting in the most severe form of alpha thalassemia, Hemoglobin Barts Hydrops Fetalis." []
is_a: SCDO:0001386 ! Alpha-Globin Locus Deletion
relationship: RO:0003303 SCDO:0000518 ! causes condition Hemoglobin Barts Hydrops Fetalis
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001388
name: Insertion
def: "Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt genetic translation of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation." []
synonym: "Gene Insertion" EXACT []
synonym: "Insertion Mutation" EXACT []
xref: MESH:D016254
is_a: IDOMAL:50000026 ! Mutation
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016254 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001388 xsd:string

[Term]
id: SCDO:0001436
name: Oxygen Therapy
def: "The administration of oxygen to an individual. It is of paramount importance in the peri-operative care of SCD patients as hypoxaemia predisposes to sickling." []
synonym: "Supplemental Oxygen Therapy" EXACT []
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: SCDO:0000340 NCIT:C94624
property_value: SCDO:0000340 SCDO:1000145
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0001511
name: Renal Medullary Carcinoma
def: "Renal medullary carcinoma is a rare, aggressive subtype of renal cell carcinoma characterized by a large, white or tan, firm, infiltrative tumor with microabscess-like foci centered in the renal medulla, typically presenting with hematuria, abdominal/flank pain, weight loss and fever. It is associated with sickle cell trait and disease and metastasis to the bones and lungs is common at time of diagnosis." []
synonym: "Kidney Medullary Carcinoma" EXACT []
synonym: "Renal Medullary Cancer" EXACT []
synonym: "RMC" EXACT []
xref: ORPHA:319319
is_a: HP:0000077 ! Abnormality of the Kidney
is_a: SCDO:0001054 ! Sickle Cell Related Cancer
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source "Shetty A, Matrana MR. Renal medullary carcinoma: a case report and brief review of the literature. Ochsner J. 2014;14(2):270-5." xsd:string
property_value: SCDO:0000340 http://www.orpha.net/ORDO/Orphanet_319319 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001511 xsd:string

[Term]
id: SCDO:0001551
name: Ethnolinguistics
def: "A part of anthropological linguistics concerned with the interrelation between a language and the cultural behavior of those who speak it." []
xref: APAONTO:Ethnolinguistics
is_a: NCIT:C16495 ! Demographic Factor
property_value: http://purl.org/dc/elements/1.1/source https://en.wikipedia.org/wiki/Ethnolinguistics
property_value: SCDO:0000340 "details"
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001551 xsd:string

[Term]
id: SCDO:0001604
name: Steady State
def: "That period when the patient with sickle cell anaemia is free of infection, pain, or other disease processes." []
synonym: "SCD Steady State" EXACT []
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 "Juwah, A. I., Nlemadim, E. U., & Kaine, W. (2004). Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria. Archives of disease in childhood, 89(6), 572-576." xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0001611
name: deprecated-Renal Insufficiency
def: "A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism." []
is_a: SCDO:0001336 ! from phenotype
is_obsolete: true
replaced_by: SCDO:0000674

[Term]
id: SCDO:0001624
name: Non-Anemic
def: "Not anemic, i.e. no reduction in erythrocytes volume and/or hemoglobin concentration." []
synonym: "Nonanemic" EXACT []
is_a: NCIT:C3833 ! Asymptomatic
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001626
name: Nonsense Codon
def: "An amino acid-specifying codon that has been converted to a stop codon by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon." []
xref: MESH:D018389
is_a: SCDO:0004623 ! Codon
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018389 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001626 xsd:string

[Term]
id: SCDO:0001715
name: deprecated-Neuropathic Pain
def: "Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat." []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000303 "This term already exists in the ontology as 'Chronic Neuropathic Pain' (SCDO:0000228), however when searching other ontologies, the term 'chronic' is included in the definition. I have therefore edited the definition to include the term 'chronic'. Please review as to whether we need to change the label that currently exists in SCDO. Is treated with: amitriptyline, duloxetine, gabapentin, or pregabalin." xsd:string
is_obsolete: true
replaced_by: SCDO:0000228

[Term]
id: SCDO:0001751
name: Homozygous Deletion of HBA2
def: "Deletion of both HBA2 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia." []
synonym: "Trans Deletion of HBA2" EXACT []
is_a: SCDO:0001386 ! Alpha-Globin Locus Deletion
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 Alpha:Thalassemia
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001765
name: Beta-Minus Thalassemia Mutation
def: "A mutation in the beta-globin gene, HBB, that results in reduced beta globin synthesis." []
is_a: SCDO:0009731 ! Beta Thalassemia Mutation
relationship: RO:0003303 SCDO:0000110 ! causes condition Beta Minus Thalassemia
relationship: SCDO:1000184 SCDO:1000159 ! contributes to genotype Hemoglobin Genotype S/Beta Minus Thalassaemia
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0001851
name: Tachycardia
def: "A rapid heartrate that exceeds the range of the normal resting heartrate for age, gender or patient population." []
synonym: "Fast Heart Rate" EXACT []
synonym: "Heart Racing" EXACT []
synonym: "Racing Heart" EXACT []
xref: HP:0001649
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000303 "Suggest update to description in HPO.\nThe original description stated 'A rapid heartrate that exceeds the range of the normal resting heartrate for age', however I think it should be recommended that gender and patient population be included." xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/HP_0001649 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0001997
name: Crystallisation of Hemoglobin
def: "The process whereby a mutation in a hemoglobin molecule causes conformational changes in the hemoglobin molecule, which cause increased hydrophobicity of the molecule, which result in the formation of crystals consisting of the mutated hemoglobin molecules. This type of crystallisation is observed in hemoglobins with the HbC mutation." []
synonym: "Crystallisation of Haemoglobin" EXACT []
synonym: "Crystallization of Haemoglobin" EXACT []
synonym: "Crystallization of Hemoglobin" EXACT []
synonym: "Haemoglobin Crystallisation" EXACT []
synonym: "Haemoglobin Crystallization" EXACT []
synonym: "Hemoglobin Crystallisation" EXACT []
synonym: "Hemoglobin Crystallization" EXACT []
is_a: SCDO:1000253 ! Abnormal Biological Process
relationship: SCDO:1000210 SCDO:1000041 ! has causal or contributing genetic variation HBB, GLU6LYS
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0002039
name: Zinc Deficiency
def: "A deficiency of the essential metal Zinc; an essential cofactor for many enzymes. Zinc deficiency is caused by a lack of zinc in the diet, loss of zinc after absorption, for example through loss through burns, inability to absorb Zinc, or increased loss through exercise." []
xref: EFO:1000003
is_a: SCDO:1000261 ! Avitaminosis
property_value: SCDO:0000340 EFO:1000003
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002039 xsd:string

[Term]
id: SCDO:0002106
name: Splenic Infarction
def: "Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis." []
xref: EFO:1001190
is_a: HP:0001743 ! Abnormality of the Spleen
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_1001190 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002106 xsd:string

[Term]
id: SCDO:0002107
name: deprecated-Nature of Mutations
def: "This represents the phenotypic feature of mutational effects on a given property of an organism biological system [Gaston K. Mazandu, []]." []
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true

[Term]
id: SCDO:0002125
name: Confidentiality
def: "The privacy of information and its protection against unauthorized disclosure." []
synonym: "Privileged Communications" EXACT []
xref: MESH:D003219
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003219 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002125 xsd:string

[Term]
id: SCDO:0002130
name: Transcriptome
def: "The pattern of gene expression at the level of genetic transcription in a specific organism or under specific circumstances in specific cells." []
synonym: "Gene Expression Levels" EXACT []
synonym: "Gene Expression Profile" EXACT []
synonym: "Gene Expression Profiles" EXACT []
xref: MESH:D059467
is_a: SCDO:0005722 ! Genetic Structure
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D059467 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002130 xsd:string

[Term]
id: SCDO:0002240
name: Disease Severity
def: "The presence and extensiveness of a disease in the body. It is objectively evaluated through diagnostic testing and physiological examination of the impaired biological organs or tissues, in cases in which disease severity can be distinguished from other realms of health, as in heart disease." []
synonym: "Severity" EXACT []
is_a: NCIT:C43646 ! Association
property_value: SCDO:0000303 "Request inclusion into relevant ontology.\nThis exists in the Influenza Ontology, but their definition is not ideal." xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/15152704
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:0002243
name: Research Participant Compensation
def: "Reimbursement of research participants for costs directly incurred during the research, such as travel costs and reasonable compensation for their inconvenience and time spent. Compensation can be monetary or non-monetary." []
comment: Research participants should be reasonably reimbursed for costs directly incurred during the research, such as travel costs, and compensated reasonably for their inconvenience and time spent. Compensation can be monetary or non-monetary. Compensation must not be so large as to induce potential participants to consent to participate in the research against their better judgment ("undue inducement"). A local research ethics committee must approve reimbursement and compensation for research participants.
synonym: "Study Participant Compensation" EXACT []
is_a: NCIT:C19332 ! Personal Attribute
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nThe label for this term has been changed to be more specific than the original \"Compensation\"." xsd:string
property_value: SCDO:0000340 "International Ethical Guidelines for Health-related Research Involving Humans, Fourth Edition. Geneva, Council for International Organizations of Medical Sciences (CIOMS); 2016." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0002305
name: Hemoglobin D Disease Causal Mutation
def: "A mutation wholly or partly responsible for causing Hemoglobin D Disease." []
is_a: IDOMAL:50000026 ! Mutation
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0002337
name: Ethical Conduct
def: "The abiding by applicable principles such as 1. compliance by research institutions; 2. obtaining and documenting informed consent; 3. Research Ethics Committee membership function, operations, review of research, and record keeping; 4. additional protection for certain vulnerable research subjects - pregnant women, prisoners, and children" []
is_a: SCDO:1000430 ! Ethics Related Concept
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects of Research. [Bethesda, Md.]" xsd:string
property_value: SCDO:0000340 "Research ethics committees: Basic concepts for capacity building. International Ethical Guidelines for Health-related Research Involving Humans, Fourth Edition. Geneva. Council for International Organizations of Medical Sciences (CIOMS); 2016." xsd:string
property_value: SCDO:0000340 "The Commission, 1978. World Health Organization. Geneva: WHO Document Production Services; 2009." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0002475
name: Beta-Zero Thalassemia Mutation
def: "A mutation in the beta-globin gene, HBB, that results in absent beta globin synthesis." []
synonym: "Beta Null Mutation" EXACT []
is_a: SCDO:0009731 ! Beta Thalassemia Mutation
relationship: RO:0003303 SCDO:0000115 ! causes condition Beta Zero Thalassemia
relationship: SCDO:1000184 SCDO:1000067 ! contributes to genotype Hemoglobin Genotype S/Beta Zero Thalassaemia
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0002674
name: Abnormality of Metabolism/Homeostasis
def: "An abnormality of the body's metabolism or homeostasis." []
synonym: "Homeostasis Abnormality" EXACT []
synonym: "Metabolism Abnormality" EXACT []
xref: HP:0001939
is_a: HP:0000118 ! Abnormal Phenotype
is_a: MP:0005376 ! Metabolism/Homeostasis Phenotype
property_value: SCDO:0000303 "Suggest update to description in HPO. Currenlty the HPO does not have a description." xsd:string
property_value: SCDO:0000340 HP:0001939
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0002798
name: Pharmacogenomic Variants
def: "Naturally occurring genetic variations associated with drug response. While these variants are not markers for genetic predisposition to disease, they influence pharmacokinetics and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., angiotensin converting enzyme; cytochrome P-450 CYP2D6)." []
xref: MESH:D000071184
is_a: NCIT:C17004 ! Genetic Polymorphism
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000071184
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002798 xsd:string

[Term]
id: SCDO:0002814
name: deprecated Globin Gene
def: "'The hemoglobin molecule that transports oxygen in the blood is made up of a number of components. Human hemoglobin is a tetramer: in adults it is made up of two alpha globins and two beta globins; in the fetus, of two alpha and two g globins; and in the embryo, two e and two z globins. The sequences of these five globin types are similar and the genes that code for them occur in clusters on the chromosomes. In humans, there are two main clusters of globin genes: the alpha globin cluster on chromosome 16 and the beta globin cluster on chromosome 11. [Curator team: []]'" []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000340 http://www2.nau.edu/~bio372-c/class/evolution/glbgnclst.htm xsd:string
is_obsolete: true
replaced_by: SCDO:0000456

[Term]
id: SCDO:0002829
name: Sample
def: "A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a material) to be used for testing, analysis, inspection, investigation, demonstration, or trial use." []
xref: SIO:001050
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 SIO:001050.rdf
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0002829 xsd:string

[Term]
id: SCDO:0002939
name: Polymerised Hemoglobin
def: "Deoxygenated malfunctioning or mutated hemoglobins which clump together and form a long polymer in a process called polymerisation." []
synonym: "Hemoglobin Polymer" EXACT []
synonym: "Polymerised Haemoglobin" EXACT []
synonym: "Polymerized Hemoglobin" EXACT []
synonym: "Sickle Hemoglobin Polymer" EXACT []
synonym: "Sickling Hemoglobin" EXACT []
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Khuthala Mnika)" xsd:string
property_value: SCDO:0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\".\n\nDescription still needs work." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0003028
name: Ethnic Status
def: "A person's ethnic status, whether conserved or mixed ethnicity." []
synonym: "Tribe" EXACT []
is_a: SCDO:0001551 ! Ethnolinguistics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (curators)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0003065
name: obsolete Non-SCD Structural Variants
def: "Genetic variation in the structure leading to the abnomality of protein structure in non-sickle cell disease hemoglobin." []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "Curation completed by the SCDO curator team: Clair." xsd:string
is_obsolete: true

[Term]
id: SCDO:0003572
name: Consent Form
def: "Documents describing a medical treatment or research project, including proposed procedures, risks, and alternatives, that are to be signed by an individual, or the individual's proxy, to indicate his/her understanding of the document and a willingness to undergo the treatment or to participate in the research." []
synonym: "Consent Forms" EXACT []
xref: MESH:D032962
is_a: SCDO:0007597 ! Descriptor of Consent
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D032962 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003572 xsd:string

[Term]
id: SCDO:0003675
name: Single Nucleotide Polymorphism
def: "A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population." []
xref: MESH:D020641
is_a: NCIT:C17004 ! Genetic Polymorphism
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D020641
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003675 xsd:string

[Term]
id: SCDO:0003696
name: Peripheral Blood Film
def: "A procedure in which a sample of peripheral blood is viewed under a microscope to count different circulating blood cells (red blood cells, white blood cells, platelets, etc.) and see whether the cells look normal." []
synonym: "Peripheral Blood Film Examination" EXACT []
synonym: "Peripheral Blood Smear" EXACT []
is_a: NCIT:C79903 ! Blood Smear
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.cancer.gov/publications/dictionaries/cancer-terms/def/peripheral-blood-smear
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0003712
name: Proxy Consent
def: "A legal representation or family member of the participant gives consent on behalf of the patient." []
synonym: "Third-Party Consent" EXACT []
is_a: NCIT:C25460 ! Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Victoria Nembaware)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology.\nMESH has the term Third-party consent, but the description's not suitable." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0003736
name: Dynamic Consent
def: "Dynamic consent is a personalised, communication interface to enable greater participant engagement in clinical and research activities.The interface facilitates two-way communication to stimulate a more engaged, informed and scientifically literate participant population where individuals can tailor and manage their own consent preferences. It has the potential to be applied more broadly to situations where there are multiple and varied uses of data requiring different kinds of consent over a period of time." []
is_a: SCDO:0007087 ! Informed Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into ICO below \"Informed Consent\"." xsd:string
property_value: SCDO:0000340 https://www.nature.com/articles/ejhg201471 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0003742
name: Splenectomy
def: "Surgical procedure involving either partial or entire removal of the spleen." []
synonym: "Splenectomies" EXACT []
xref: MESH:D013156
is_a: SCDO:0001133 ! Symptomatic Therapeutics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D013156
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0003742 xsd:string

[Term]
id: SCDO:0003807
name: Abnormal Hemoglobin
def: "Hemoglobin characterized by structural alterations within the molecule that confer an inherited health condition phenotype. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains." []
synonym: "Abnormal Hemoglobin Variant" EXACT []
synonym: "Abnormal Hemoglobins" EXACT []
synonym: "Abnormal Variant of Hemoglobin" EXACT []
is_a: HP:0001877 ! Abnormal Erythrocyte Morphology
is_a: SCDO:0006921 ! Hemoglobin Variant
property_value: http://purl.org/dc/elements/1.1/source HP:0011902
property_value: SCDO:0000303 "Suggest HPO to update their term description and to move terms related to hemoglobin concentration below \"Abnormal Hemoglobin Concentration\".\n\nInclude as a sub-class \"Hemoglobin S-Providence\"?" xsd:string
property_value: SCDO:0000340 http://www.reference.md/files/D006/mD006455.html
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0003894
name: Gap PCR
def: "The polymerase chain reaction (PCR) is the most common method to detect the deletional thalassaemias. Gap-PCR amplifies the deleted DNA sequence using the primers flanking the deleted region 10. Three primers are designed for each deletion to amplify the normal (undeleted) and deleted gene sequences." []
is_a: SCDO:0000913 ! Polymerase Chain Reaction
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 "Kho SL, Chua KH, George E, Tan JA. A novel gap-PCR with high resolution melting analysis for the detection of α-thalassaemia Southeast Asian and Filipino β°-thalassaemia deletion. Sci Rep. 2015;5:13937. Published 2015 Sep 14. doi:10.1038/srep13937" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0004061
name: Genotype
def: "The genetic constitution of the individual, comprising the alleles present at each genetic locus." []
xref: MESH:D005838
is_a: SCDO:0000765 ! Genetic Phenomena
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005838
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004061 xsd:string

[Term]
id: SCDO:0004078
name: Girdle Syndrome
def: "Characterized by an established ileus, with vomiting, a silent distended abdomen and distended bowel loops and fluid levels on abdominal x-ray. Some hepatic enlargement is common, and it is often associated with bilateral basal lung consolidation (chest syndrome)." []
synonym: "Mesenteric Syndrome" EXACT []
is_a: HP:0000118 ! Abnormal Phenotype
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nCan be treated with analgesia, IV fluids, and antibiotics if patient is febrile." xsd:string
property_value: SCDO:0000340 http://www.sickle-thal.nwlh.nhs.uk/Documents/Sickle_Cell_Disease_Paediatric_Guideline_ICHT_v1.0_Oct%202015.pdf
property_value: SCDO:0000340 "SCD Management guidelines - Tanzania" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0004139
name: Adult Hemoglobin
def: "The most common and normal adult human hemoglobin tetramer, comprising over 97% of the total red blood cell hemoglobin and consisting of two alpha chains and two beta chains." []
synonym: "Adult Haemoglobin" EXACT []
synonym: "alpha2beta2" EXACT []
synonym: "Haemoglobin A" EXACT []
synonym: "Haemoglobin A1" EXACT []
synonym: "Hb A" EXACT []
synonym: "HbA" EXACT []
synonym: "Hemoglobin A" EXACT []
synonym: "Hemoglobin A1" EXACT []
xref: MESH:D006441
is_a: SCDO:0006835 ! Normal Hemoglobin
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\".\nSuggest update to description in MESH." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006441
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0004187
name: Hemolytic Crisis
def: "May be caused by an acute VOC, malarial infection or oxidant drug exposure in individuals with concomitant glucose-6-phosphate dehydrogenase (G6PD) deficiency. Haemolytic crisis may be distinguished from aplastic crisis by the finding of a reticulocytosis as opposed to a reticulocytopenia." []
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - South Africa" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0004277
name: Assent
def: "A term used to express willingness to participate in research by persons who are by definition too young to give informed consent but who are old enough to understand the proposed research in general, its expected risks and possible benefits, and the activities expected of them as subjects." []
xref: ICO:0000143
is_a: SCDO:0007597 ! Descriptor of Consent
property_value: SCDO:0000303 "The source term seems to be deprecated in the ICO." xsd:string
property_value: SCDO:0000340 ICO:0000143
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0004444
name: Delta Beta Globin Fusion Chain
def: "The protein product of the fusion of the gene products of the HBD and HBB genes that causes the mutation which causes the Hemoglobin Lepore Trait." []
synonym: "Crossover between delta and beta globin gene loci" EXACT []
synonym: "Delta Beta Globin Chain Fusion Product" EXACT []
is_a: SCDO:1000012 ! Beta-Globin Family Members
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0004576
name: Chronic Hypersplenism
def: "Chronic splenic sequestration associated with enlarged spleen and cytopaenia with anaemia and reduction in white blood cells and platelets. The anaemia is usually chronic in nature and patients rarely present with signs of heart failure." []
is_a: SCDO:0001334 ! Chronic Phenotype
is_a: SCDO:0006905 ! Hypersplenism
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO below \"Hypersplenism\"." xsd:string
property_value: SCDO:0000340 "Management of Sickle Cell Disease - The United Republic of Tanzania (By Ministry of Health)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0004598
name: Anticodon
def: "The sequential set of three nucleotides in transfer RNA that interacts with its complement in messenger RNA, the Codon, during translation in the ribosome." []
xref: MESH:D000926
is_a: SCDO:0005593 ! Genetic Code
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000926 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004598 xsd:string

[Term]
id: SCDO:0004623
name: Codon
def: "Also known as sense codon, a set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (terminator codon). Most codons are universal, but some organisms do not produce the transfer RNAs complementary to all codons. These codons are referred to as unassigned codons (nonsense codons)." []
xref: MESH:D003062
is_a: SCDO:0005593 ! Genetic Code
property_value: SCDO:0000303 "Add \"Terminator Codon\" as a parent of \"Nonsense Codon\" as in MESH?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003062 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004623 xsd:string

[Term]
id: SCDO:0004716
name: Initiator Codon
def: "A codon that directs initiation of protein translation (Translation, Genetic) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon." []
synonym: "Codon, Initiation" EXACT []
synonym: "Codon, Initiator" EXACT []
synonym: "Initiation Codon" EXACT []
synonym: "Initiation Codons" EXACT []
synonym: "Initiator Codons" EXACT []
synonym: "Start Codon" EXACT []
synonym: "Start Codons" EXACT []
xref: MESH:D018387
is_a: SCDO:0004623 ! Codon
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D018387 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004716 xsd:string

[Term]
id: SCDO:0004829
name: Transient Ischemic Attack
def: "Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic)." []
synonym: "Mini Stroke" EXACT []
synonym: "TIA" EXACT []
synonym: "Transient Ischemic Attacks" EXACT []
xref: EFO:0003764
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_0003764 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004829 xsd:string

[Term]
id: SCDO:0004836
name: Angina
def: "A chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood." []
xref: OAE:0002122
is_a: HP:0011025 ! Abnormal Cardiovascular System Physiology
property_value: SCDO:0000340 OAE:0002122
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0004836 xsd:string

[Term]
id: SCDO:0004847
name: Acute Hepatic Sequestration
def: "A rarely recognized complication of vaso-occlusive crisis. It is characterized by a presentation of right upper quadrant pain in the liver. A smooth, tender, enlarged liver is noted on physical exam. The lab values show a decrease in the hemoglobin/hematocrit. An increase in reticulocyte count is also seen." []
is_a: HP:0001392 ! Abnormality of the Liver
is_a: NCIT:C115224 ! Hepatic Complication
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Norris, W. E. (2004). Acute hepatic sequestration in sickle cell disease. Journal of the National Medical Association, 96(9), 1235-1239. The Management of Sickle Cell Disease. 1984. (Revised June 2002). NIH publication 02-2117. Available at http:/www.nhlbi.nih.gov/health/prof/blood/sickle/sc." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0004860
name: deprecated-Amoxicillin
def: "'A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. [Curator team: []]'" []
xref: CHEBI:2676
is_a: SCDO:1000035 ! from therapeutics
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_2676 xsd:string
is_obsolete: true
replaced_by: SCDO:0002381

[Term]
id: SCDO:0004888
name: Functional Hyposplenism
def: "An acquired disorder caused by several hematological and immunological diseases and characterized by impairment of splenic function." []
synonym: "FH" EXACT []
is_a: HP:0001743 ! Abnormality of the Spleen
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Kirkineska L, Perifanis V, Vasiliadis T. Functional hyposplenism. Hippokratia. 2014;18(1):7–11." xsd:string
property_value: http://purl.org/dc/elements/1.1/source "Vijay, V., Cavenagh, J.D. and Yate, P., 1998. The anaesthetist's role in acute sickle cell crisis. British journal of anaesthesia, 80(6), pp.820-828." xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps below \"Abnormality of the Spleen\" in the HPO." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0004905
name: Beta-Globin Locus Deletion
def: "Deletion of a part of the beta-globin locus." []
synonym: "Beta-Globin Cluster Deletion" EXACT []
synonym: "Beta-Globin Gene Cluster Deletion" EXACT []
synonym: "Hemaglobin Beta Gene Deletion" EXACT []
is_a: NCIT:C19296 ! Deletion Mutation
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.bloodjournal.org/content/126/23/3374?sso-checked=true
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0538"
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0005167
name: Chronic Anemia
def: "Long lasting form of anemia." []
is_a: HP:0001903 ! Anemia
is_a: SCDO:0001334 ! Chronic Phenotype
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nNo online description for this term exists, would it be sufficient to say 'Long lasting form of anemia'? or is there a better definition specific for sickle cell anemia?" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0005191
name: Hyperhemolysis
def: "An increase in the rate of hemolysis, in conjunction with specific clinical complications of sickle cell disease." []
is_a: HP:0001392 ! Abnormality of the Liver
is_a: MP:0010163 ! Hemolysis
is_a: NCIT:C115224 ! Hepatic Complication
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into Mammalian Phenotype ontology below \"Hemolysis\".\n\nInfo also provided by the definition source: 'Hyperhemolysis should be typified by an acute reduction in hemoglobin level associated with higher than usual reticulocyte counts and perhaps an unaccountable and sudden increase in LDH.'" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. Martin H. Steinberg, Bernard G. Forget, Douglas R. Higgs, David J. Weatherall. Cambridge University Press, 17 Aug 2009" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0005243
name: Comparative Genomic Hybridisation
def: "A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations." []
synonym: "CGH" EXACT []
synonym: "Comparative Genome Hybridization" EXACT []
synonym: "Comparative Genomic Analysis" EXACT []
synonym: "Comparative Genomic Hybridizations" EXACT []
xref: MESH:D055028
is_a: SCDO:0000448 ! Genetic Technique
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055028
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005243 xsd:string

[Term]
id: SCDO:0005279
name: deprecated High Reticulocyte Count
def: "An abnormally high number of reticulocytes per unit volume of blood. The normal fraction of reticulocytes in the blood depends on the clinical situation but is usually 0.5% to 2.5% in adults and 2% to 6% in infants." []
synonym: "Reticulocyte Count High" EXACT []
is_a: SCDO:0000359 ! deprecated terms
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nSymptom of splenic sequestration, or increased haemolysis." xsd:string
property_value: SCDO:0000340 https://en.wikipedia.org/wiki/Reticulocyte
property_value: SCDO:1000288 "Negligable" xsd:string
is_obsolete: true
replaced_by: SCDO:0001272

[Term]
id: SCDO:0005339
name: Globin Phenotype
def: "The physical characteristics of the globin polypeptides that form hemoglobins." []
synonym: "Globin Chain Phenotype" EXACT []
is_a: SCDO:0009613 ! Protein Phenotype
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/20339107 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0005379
name: Database
def: "Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means." []
synonym: "Data Base" EXACT []
xref: MESH:D019991
is_a: SCDO:0300003 ! Publication Formats
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D019991 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005379 xsd:string

[Term]
id: SCDO:0005446
name: Fetal Hemoglobin
def: "The major component of hemoglobin in the fetus. This hemoglobin has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by leukemia and several types of anemia." []
synonym: "Fetal Haemoglobin" EXACT []
synonym: "Foetal Haemoglobin" EXACT []
synonym: "Haemoglobin F" EXACT []
synonym: "Hb F" EXACT []
synonym: "HbF" EXACT []
synonym: "Hemoglobin F" EXACT []
xref: MESH:D005319
is_a: SCDO:0006835 ! Normal Hemoglobin
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\", for completion sake." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005319
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005446 xsd:string

[Term]
id: SCDO:0005464
name: Myocardial Ischemia
def: "A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction)." []
xref: EFO:1001375
is_a: SCDO:0000665 ! Ischemia
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_1001375 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005464 xsd:string

[Term]
id: SCDO:0005580
name: deprecated-Avascular Necrosis of the Femoral Head
def: "Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterised by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty." []
synonym: "ANFH" EXACT []
xref: Orphanet:86820
is_a: NCIT:C118385 ! deprecated-Avascular Necrosis
property_value: SCDO:0000340 http://www.orpha.net/ORDO/Orphanet_86820 xsd:string
is_obsolete: true
replaced_by: SCDO:0000842

[Term]
id: SCDO:0005593
name: Genetic Code
def: "The meaning ascribed to the base sequence with respect to how it is translated into amino acid sequence. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons." []
xref: MESH:D005815
is_a: SCDO:0005722 ! Genetic Structure
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005815 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005593 xsd:string

[Term]
id: SCDO:0005671
name: HBB and HBD Deletion
def: "Deletion of the HBB and HBD genes that results in delta-beta thalassemia." []
is_a: SCDO:0004905 ! Beta-Globin Locus Deletion
is_a: SCDO:1000366 ! Delta Beta Thalassemia Mutation
relationship: RO:0003303 SCDO:0000343 ! causes condition Delta Beta Thalassemia
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0005722
name: Genetic Structure
def: "A biological object that contains genetic information and that is involved in transmitting genetically encoded traits from one organism to another." []
synonym: "Genetic Structures" EXACT []
xref: MESH:D040342
is_a: SCDO:0000765 ! Genetic Phenomena
property_value: SCDO:0000340 https://purl.bioontology.org/ontology/MESH/D040342
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0005722 xsd:string

[Term]
id: SCDO:0005927
name: Justice
def: "An ethical principle that obligates one to treat people fairly. Distributive justice refers to allocating benefits and harms fairly; procedural justice refers to using fair processes to make decisions that affect people; formal justice refers to treating similar cases in the same way. In human subjects research, the principle of justice implies that subjects should be selected equitably." []
is_a: GSSO:003239 ! Ethical Principle
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.niehs.nih.gov/research/resources/bioethics/glossary/index.cfm#human-subjects-research xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0006000
name: Fever
def: "Elevated body temperature due to failed thermoregulation, or inflammation or immune responses." []
synonym: "Pyrexia" EXACT []
synonym: "Pyrogenic Reaction" EXACT []
xref: HP:0001945
xref: NCIT:C3038
is_a: SCDO:0002674 ! Abnormality of Metabolism/Homeostasis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000303 "Merged the two descriptions from NCIT and HP\n\nSuggest update to description in NCIT and HP." xsd:string
property_value: SCDO:0000340 HP:0001945
property_value: SCDO:0000340 NCIT:C3038
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0006036
name: Minor
def: "A person who has not attained the age at which full civil rights are accorded." []
xref: MESH:D033242
is_a: SCDO:0002125 ! Confidentiality
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D033242 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006036 xsd:string

[Term]
id: SCDO:0006070
name: Mixed Ethnicity
def: "An ethnic group that includes persons with significant ethnic contributions from more than one group." []
xref: ERO:0002032
is_a: SCDO:0003028 ! Ethnic Status
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0002032 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006070 xsd:string

[Term]
id: SCDO:0006339
name: Research
def: "Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws." []
xref: MESH:D012106
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012106 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006339 xsd:string

[Term]
id: SCDO:0006429
name: Gallbladder Empyema
def: "An uncommon complication of cholecystitis and refers to a situation where the gallbladder lumen is filled and distended by purulent material (pus)." []
is_a: HP:0025031 ! Abnormality of the Digestive System
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://radiopaedia.org/articles/gallbladder-empyema xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0006461
name: Acutely Severe Anemia
def: "Aplasia or hemolysis may be precipitated by another illness/infection in sickle cell disease patients. Acutely severe anemia is defined as Hb < 5g/dl or a recent acute drop in HB > 2g/dl below the individual's steady state value. If no steady state value is available, it can be detected by the presence of acutely symptomatic anemia (i.e. tachycardia, cardiac failure, shock)." []
is_a: HP:0001903 ! Anemia
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology.\n\nPlease check with the working group as to how they feel about the label for this term." xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - Tanzania" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0006517
name: Human Subject Research
def: "Research involving the collection, storage, or use of private data or biological samples from living individuals by means of interactions, interventions, surveys, or other research methods or procedures." []
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 https://www.niehs.nih.gov/research/resources/bioethics/glossary/index.cfm#human-subjects-research xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:0006589
name: Cordocentesis
def: "The collecting of fetal blood samples typically via endoscopic ultrasound guided fine needle aspiration from the umbilical vein, followed by examination of the blood to detect fetal abnormalities." []
synonym: "Fetal Blood Sampling" EXACT []
synonym: "Percutaneous Umbilical Cord Blood Sampling" EXACT []
synonym: "PUBS" EXACT []
synonym: "Umbilical Vein Sampling" EXACT []
xref: MESH:D017218
is_a: SCDO:0000505 ! Hematology Screening Test
is_a: SCDO:0000919 ! Prenatal Screening for Sickle Cell
property_value: SCDO:0000303 "Suggest update to description in MESH." xsd:string
property_value: SCDO:0000340 http://americanpregnancy.org/prenatal-testing/cordocentesis/
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017218
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0006613
name: Material Transfer Agreement
def: "A material transfer agreement (MTA) is a type of legally enforceable contract employed by research institutions and companies to set the terms under which their materials and associated data may be obtained and used by others." []
synonym: "MTA" EXACT []
is_a: SCDO:0300006 ! Information Disclosure
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Henderson J (2007) Counterpoint: MTAs are a practical necessity. Nat Biotechnol 25: 722–724." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0006706
name: Bioethics
def: "A branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care." []
synonym: "Biomedical Ethics" EXACT []
synonym: "Health Care Ethics" EXACT []
xref: MESH:D001675
is_a: NCIT:C39796 ! Ethics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001675 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006706 xsd:string

[Term]
id: SCDO:0006832
name: Ascorbic Acid Deficiency
def: "A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)" []
synonym: "Ascorbic Acid Deficiencies" EXACT []
synonym: "Vitamin C Deficiencies" EXACT []
synonym: "Vitamin C Deficiency" EXACT []
xref: MESH:D001206
is_a: SCDO:1000261 ! Avitaminosis
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001206
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006832 xsd:string

[Term]
id: SCDO:0006833
name: Moyamoya Disease
def: "A rare intracranial arteriopathy involving progressive stenosis of the cerebral vasculature located at the base of the brain causing transient ischemic attacks or strokes." []
synonym: "MMD" EXACT []
xref: ORPHA:2573
is_a: SCDO:0000267 ! Comorbid Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://www.orpha.net/ORDO/Orphanet_2573 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006833 xsd:string

[Term]
id: SCDO:0006835
name: Normal Hemoglobin
def: "Hemoglobin that presents no inherited health condition phenotype." []
synonym: "Hemoglobin Normal" EXACT []
synonym: "Hemoglobin Normal Variant" EXACT []
is_a: NCIT:C16676 ! Hemoglobin
is_a: SCDO:0009613 ! Protein Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0006847
name: Aplastic Crisis
def: "An acute form of acquired red cell aplasia. A significant change in blood picture is observed, characterised by a precipitous fall in the haemoglobin level (>20 g/l beyond steady state level) and reduced (<1%) or absent reticulocytes in the peripheral blood. The total white blood cell or platelet counts may or may not be affected. In addition, there is no significant increase in the unconjugated fraction of serum bilirubin.The most common cause is infection by parvovirus B19, a DNA virus that replicates inside immature red blood cells in the bone marrow, resulting in severe anaemia (hemoglobin levels well below steady state) and low reticulocyte count. It is rarely recurrent." []
synonym: "Aplastic Crises" EXACT []
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Juwah, A. I., Nlemadim, E. U., & Kaine, W. (2004). Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria. Archives of disease in childhood, 89(6), 572-576." xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - Jamaica" xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - Nigeria" xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - South Africa" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0006860
name: HBG1 and/or HBG2 Mutations
def: "Mutations in the HBG1 and/or HBG2 genes. Such mutations can lead to variably increased levels of fetal hemoglobin (Hb) (Hb F, alpha2gamma2) in the syndrome of hereditary persistence of fetal Hb (HPFH)." []
is_a: IDOMAL:50000026 ! Mutation
relationship: SCDO:1000184 SCDO:1000235 ! contributes to genotype Hereditary Persistence of Fetal Hemoglobin Genotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/24144231
property_value: SCDO:0000303 "Request inclusion into relevant ontology.\n\nPerhaps add sub-classes of specific mutations as in the dc:source." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0006905
name: Hypersplenism
def: "Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy." []
synonym: "Hypersplenia" EXACT []
xref: EFO:1000975
is_a: HP:0001743 ! Abnormality of the Spleen
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source "Al-Salem, A. H. (2011). Splenic Complications of Sickle Cell Anemia and the Role of Splenectomy. ISRN Hematology, 2011, 864257. http://doi.org/10.5402/2011/864257" xsd:string
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_1000975 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0006905 xsd:string

[Term]
id: SCDO:0006909
name: Hyper-Hemolytic Crisis
def: "Significant change in blood picture characterised by a precipitous fall in the haemoglobin level associated with jaundice, marked reticulocytosis, and polychromasia on the blood smear, increased unconju- gated hyperbilirubinaemia, and increased urobilinogen content in urine above the steady state level for each individual patient." []
is_a: SCDO:0004187 ! Hemolytic Crisis
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Juwah, A. I., Nlemadim, E. U., & Kaine, W. (2004). Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria. Archives of disease in childhood, 89(6), 572-576." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0006911
name: Conserved Ethnicity
def: "An ethnic group that includes persons with ethnic contributions from only one ethnic group." []
is_a: SCDO:0003028 ! Ethnic Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (curators)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0006921
name: Hemoglobin Variant
def: "Hemoglobin with altered structural and biochemical properties." []
is_a: NCIT:C16676 ! Hemoglobin
is_a: SCDO:0009613 ! Protein Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"." xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/23388674 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0007087
name: Informed Consent
def: "Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment." []
xref: MESH:D007258
is_a: NCIT:C25460 ! Consent
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D007258
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007087 xsd:string

[Term]
id: SCDO:0007161
name: Acute Splenic Sequestration Crisis
def: "Significant change in blood picture characterised by a precipitous fall in the haemoglobin level of at least 20 g/l and accompanied by a rapidly enlarging spleen or liver (greater than 2 cm from the steady state level) and reticulocytosis above the steady state level for each individual patient. Signs of acute circulatory insufficiency such tachypnoea, tachycardia, and hypotension may or may not be present. It is the earliest life-threatening complication seen in patients with SCD besides pneumococcal infections." []
synonym: "Acute Crisis Splenic Sequestration" EXACT []
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Vijay, V., Cavenagh, J.D. and Yate, P., 1998. The anaesthetist's role in acute sickle cell crisis. British journal of anaesthesia, 80(6), pp.820-828." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0007192
name: Quantitative Hemoglobinopathy
def: "A hemoglobinopathy caused by a reduced or imbalanced synthesis of a normal globin chain or by a defect in the switch between synthesis of different types of normal hemoglobin." []
synonym: "Abnormal Hemoglobin Synthesis" EXACT []
synonym: "Abnormal Synthesis Hemoglobinopathy" EXACT []
synonym: "Synthesis Hemoglobinopathy" EXACT []
is_a: SCDO:0000552 ! Hemoglobinopathy
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.diagnostics.eu.tosohbioscience.com/solutions/pathologies/haemoglobinopathies
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0007212
name: obsolete Other Molecules
def: "'Other molecules are complexes which do not contain protein or RNA, including lipids, carbohydrates, etc.'" []
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true

[Term]
id: SCDO:0007281
name: Adrenal Insufficiency
def: "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves." []
synonym: "Hypoadrenalism" EXACT []
xref: HP:0000846
is_a: HP:0000834 ! Abnormality of the Adrenal Glands
property_value: SCDO:0000303 "Suggest update to description. Not sure if they changed their description or if we adapted it." xsd:string
property_value: SCDO:0000340 HP:0000846
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0007495
name: Risk
def: "The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome." []
xref: MESH:D012306
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D012306 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007495 xsd:string

[Term]
id: SCDO:0007519
name: Community Engagement
def: "A process of inclusive participation that supports mutual respect of values, strategies, and actions for authentic partnership of people affiliated by geographic location, shared interest, or similar circumstances to address issues affecting community wellbeing." []
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Holzer et al 2014 Doi:10.1097/JIM.0000000000000097" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:0007565
name: deprecated Major Area
def: "Distinct geographical area." []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "This term was too general. Was replaced by \"Geographic Area\"." xsd:string
is_obsolete: true
replaced_by: SCDO:1000367

[Term]
id: SCDO:0007597
name: Descriptor of Consent
def: "Information or a description of consent (hypothetical or obtained) or any aspect involved in or captured in the consent process." []
is_a: SCDO:0006339 ! Research
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps the ICO." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0007618
name: deprecated-Avascular necrosis of the humeral head
def: "In situ death of bone within the humeral head due to disruption of blood supply." []
is_a: NCIT:C118385 ! deprecated-Avascular Necrosis
property_value: SCDO:0000303 "Has synonym: Osteonecrosis of the humeral head" xsd:string
property_value: SCDO:0000340 http://www.wheelessonline.com/ortho/Humeral_Head_Osteonecrosis xsd:string
is_obsolete: true
replaced_by: SCDO:1000376

[Term]
id: SCDO:0007623
name: Molecular Phenotype
def: "The molecular characteristics of a cell of tissue including expressed coding and non-coding RNAs, proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." []
xref: BAO:0170001
is_a: OGMS:0000023 ! Phenotype
property_value: SCDO:0000340 BAO?p=classes&conceptid=http%3A%2F%2Fwww.bioassayontology.org%2Fbao%23BAO:0170001
property_value: SCDO:0000340 http://www.bioassayontology.org/bao#BAO_0170001 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0007623 xsd:string

[Term]
id: SCDO:0007624
name: Beta Thalassemia Genotype
def: "HBB genetic variants that result in reduced or absent hemoglobin subunit beta production." []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000111 ! causes condition Beta Thalassemia
relationship: SCDO:1000184 SCDO:1000107 ! contributes to genotype Hemoglobin Genotype S/Beta Thalassemia
relationship: SCDO:1000222 SCDO:1000240 ! causes molecular phenotype Reduced or Absent Hemoglobin A
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "PMID: 20301599" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0007656
name: Sickle Cell Thalassemia
def: "Hemolytic anemia, in which patients are compound or double heterozygous for both the sickle cell gene and a thalassemia gene." []
synonym: "Sickle Cell-Thalassemia" EXACT []
xref: NCIT:C61237
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
is_a: SCDO:1000215 ! Structural and Quantitative Hemoglobinopathy
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 NCIT:C79903 ! diagnosed using tool Blood Smear
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:1000210 SCDO:0009731 ! has causal or contributing genetic variation Beta Thalassemia Mutation
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "Suggest update to description in NCIT" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C61237
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0007897
name: Ethics Approval
def: "A document containing the determination of the Research Ethics Committee (REC) that the clinical study with human subject participation has been reviewed and may be conducted at a particular study site within the constraints set forth by the REC and other institutional and federal requirements. The regulations require that an REC conduct continuing review of research at intervals appropriate to the degree of risk, but not less than once a year." []
is_a: SCDO:0300005 ! Research Characteristics
is_a: SCDO:1000430 ! Ethics Related Concept
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0007900
name: Embryonic Hemoglobin
def: "Hemoglobin produced in the blood islands in the embryonic yolk sac during the mesoblastic stage of gestation. There are four different embryonic hemoglobins, Hemoglobin Gower 1, Hemoglobin Gower 2, Hemoglobin Portland 1 and Hemoglobin Portland 2." []
synonym: "Hemoglobin Epsilon" EXACT []
is_a: SCDO:0006835 ! Normal Hemoglobin
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\".\n\nAdd sub-classes:\nHemoglobin Gower 1\nHemoglobin Gower 2\nHemoglobin Portland 1\nHemoglobin Portland 2" xsd:string
property_value: SCDO:0000340 Embryonic:hemoglobin
property_value: SCDO:0000340 "R Al-Mufti, H Hambley, F Farzaneh, KH Nicolaides\nHaematologica Jan 2000, 85 (7) 690-693;" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0008037
name: Acute Symptomatic Seizure
def: "A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed. It is often associated with infections, infarctions, and severe metabolic or sickle cell complications." []
synonym: "Provoked Seizures" EXACT []
synonym: "Situation-Related Seizures" EXACT []
xref: HP:0011145
is_a: SCDO:1000000 ! Acute Phenotype
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Suggest update to description in HPO." xsd:string
property_value: SCDO:0000340 HP:0011145
property_value: SCDO:0000340 "SCD Management guidelines - Jamaica" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0008251
name: Homozygous Deletion of HBA1
def: "Deletion of both HBA1 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia." []
synonym: "Trans Deletion of HBA1" EXACT []
is_a: SCDO:0001386 ! Alpha-Globin Locus Deletion
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 Alpha:Thalassemia
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0008262
name: Structural Hemoglobinopathy
def: "A hemoglobinopathy caused by the presence of structurally abnormal hemoglobins." []
synonym: "Qualitative Hemoglobinopathy" EXACT []
is_a: SCDO:0000552 ! Hemoglobinopathy
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0008595
name: Chronic Arthritis
def: "Persistence of an inflammatory event in the articulation overtime." []
is_a: HP:0001369 ! Arthritis
is_a: SCDO:0001334 ! Chronic Phenotype
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0008623
name: Vaso-Occlusion
def: "The obstruction of blood vessels by altered erythrocytes that can result in pain, anemia and tissue ischemia." []
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0008625
name: Right Upper Quadrant Syndrome
def: "Characterized by pain and discomfort in the right upper quadrant (RUQ) of the abdomen caused by a number of possible aetiologies in sickle cell disease. Causes of RUQ pain may be divided into pain originating from the liver or gall bladder versus other origins of abdominal pain in that region." []
synonym: "Right Upper Quadrant Pain" EXACT []
synonym: "RUQ Pain" EXACT []
is_a: SCDO:0000895 ! Phenotype of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - Jamaica" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0008688
name: Biobank
def: "A biobank is a collections of samples of biological substances (e.g. tissue, blood, DNA) which are linked to data about the samples and their donors. They have a dual nature as collections of samples and data and usually require investigators or institutions to agree to certain conditions as a condition for sharing samples or data with them." []
xref: OMIABIS:0000000
is_a: SCDO:0300003 ! Publication Formats
property_value: SCDO:0000303 "Suggest update to description in OMIABIS" xsd:string
property_value: SCDO:0000340 https://www.niehs.nih.gov/research/resources/bioethics/glossary/index.cfm
property_value: SCDO:0000340 OMIABIS:0000000
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0008713
name: Sickle Cell Anemia Associated with Alpha Thalassemia
def: "The concurrence of sickle cell anemia and alpha-thalassemia. This condition is thought to result in less severe hemolytic anemia due to reduced concentration of hemoglobin S and its polymerization within red blood cells." []
synonym: "Co-Inheritance of Alpha-Thalassemia and Sickle Cell Anemia" EXACT []
synonym: "Co-Inheritance of Sickle Cell Anemia and Alpha-Thalassemia" EXACT []
synonym: "Sickle Cell Anemia Associated with Coexistent Alpha Thalassemia" EXACT []
is_a: SCDO:1000106 ! Sickle Cell Disease
relationship: SCDO:0000663 SCDO:0003894 ! diagnosed using tool Gap PCR
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076272/
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0008778
name: Dental Radiograph
def: "A radiograph of dental structures made on x-ray film or stored as a digital image. The radiographs may be extraoral or intraoral. Three common types of intraoral dental images are periapical, interproximal, and occlusal radiographs." []
synonym: "Radiologic Examination, Teeth" EXACT []
is_a: SCDO:0000963 ! Radiography
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "\"dental radiograph.\" Mosby's Medical Dictionary, 8th edition. 2009. Elsevier 7 Nov. 2018 https://medical-dictionary.thefreedictionary.com/dental+radiograph" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0008888
name: Iron Chelation Therapy
def: "The removal of excess iron from the body with special drugs." []
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 EUPATH:0000215 ! treats Severe Anemia
relationship: SCDO:1000018 NCIT:C155310 ! treats Sickle Cell Disease-SD
relationship: SCDO:1000018 NCIT:C95504 ! treats Hemoglobin H Disease
relationship: SCDO:1000018 SCDO:0000115 ! treats Beta Zero Thalassemia
relationship: SCDO:1000018 SCDO:0000518 ! treats Hemoglobin Barts Hydrops Fetalis
property_value: SCDO:0000303 "Request inclusion into MESH below \"Chelation Therapy\"" xsd:string
property_value: SCDO:0000340 http://www.irondisorders.org/chelation-therapy
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0008925
name: Autonomy
def: "The capacity for self-governance, i.e. the ability to make reasonable decisions." []
is_a: GSSO:003239 ! Ethical Principle
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.hhs.gov/ohrp/sites/default/files/the-belmont-report-508c_FINAL.pdf xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.niehs.nih.gov/research/resources/bioethics/glossary/index.cfm
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0008937
name: Central Retinal Artery Occlusion
def: "Blockage of blood flow in the central retinal artery. Results in sudden painless loss of vision and occurs in children and young adults. Thrombus formation in the retinal artery occurs spontaneously or in association with hyphema, Moyamoya and acute chest sydrome. There is no associated pain and it may be unilateral or bilateral." []
xref: HP:0025342
is_a: HP:0030680 ! Abnormal Cardiovascular System Morphology
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Suggest update to description in HPO" xsd:string
property_value: SCDO:0000340 HP:0025342
property_value: SCDO:0000340 "SCD Management guidelines - Jamaica" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0008990
name: Vertebral Collapse
def: "Occurs where there is infarction of vertebral bone marrow, leading to collapse of the vertebrae with a typical 'fish mouth' appearance. It is often asymptomatic, but may cause acute and/or long term pain requiring analgesia and mechanical support such as a brace. Can be an acute or chronic bone problem in SCD." []
synonym: "Compression Fracture" EXACT []
synonym: "Fractures of Vertebral Bodies" EXACT []
synonym: "Vertebral Body Compression" EXACT []
synonym: "Vertebral Compression" EXACT []
synonym: "Vertebral Compression Fractures" EXACT []
synonym: "Vertebral Compression or Collapse" EXACT []
xref: HP:0002953
is_a: HP:0000924 ! Abnormality of the Skeletal System
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Suggest update to description in HPO (currently no description)." xsd:string
property_value: SCDO:0000340 HP:0002953
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0009089
name: Non-Maleficience
def: "Principle dictating that harm should not come to individuals as a result of their participation in a research project." []
is_a: GSSO:003239 ! Ethical Principle
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Shamoo AE and Resnik DB, Responsible Conduct of Research, 3rd ed. (New York: Oxford University Press, 2015)." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0009117
name: Folate Deficiency
def: "A nutritional condition produced by a deficiency of folic acid in the diet." []
synonym: "Deficiency of Folic Acid" EXACT []
synonym: "Deficiency of Folic Acid (Disorder)" EXACT []
synonym: "Folic Acid Deficiencies" EXACT []
synonym: "Folic Acid Deficiency" EXACT []
xref: EFO:0001070
is_a: SCDO:1000261 ! Avitaminosis
property_value: http://purl.org/dc/elements/1.1/source EFO:0001070
property_value: SCDO:0000340 EFO:0001070
property_value: SCDO:0000661 "Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives." xsd:string
property_value: SCDO:0000662 "This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009117 xsd:string

[Term]
id: SCDO:0009169
name: obsolete Sickle Plus Structural Variant
def: "A hemoglobinopathy caused by compound heterozygous inheritance of one hemoglobin S allele and one hemoglobin allele that produces structurally abnormal hemoglobin." []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552344/
is_obsolete: true

[Term]
id: SCDO:0009279
name: Unstable Hemoglobin
def: "Hemoglobin with decreased solubility in the red cell due to substitutions in the primary sequence of globin which alters the tertiary or quaternary structure of the molecule and results in a globin polypeptide/hemoglobin tetramer that is unstable and precipitates intracellularly, reducing the red blood cell lifespan." []
is_a: SCDO:0003807 ! Abnormal Hemoglobin
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"." xsd:string
property_value: SCDO:0000340 https://www.uptodate.com/contents/unstable-hemoglobin-variants
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:0009350
name: Splenic Sequestration
def: "An acute condition of intrasplenic pooling of large amounts of blood." []
comment: Can cause severely acute anemia.
synonym: "Blood Trapped in the Spleen" EXACT []
is_a: HP:0001743 ! Abnormality of the Spleen
relationship: SCDO:1000202 SCDO:0008623 ! caused by Vaso-Occlusion
relationship: SCDO:1000218 HP:0001923 ! has manifestation Reticulocytosis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Suggest update to description in the Radiology Lexicon, or use their description \"Splenic sequestration occurs in sickle cell disease when sickled red blood cells become trapped in the spleen, causing it to enlarge.\"" xsd:string
property_value: SCDO:0000340 http://www.ihtc.org/patient/blood-disorders/sickle-cell-disease/splenic-sequestration/
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0009445
name: Renal Papillary Necrosis
def: "A complication of kidney diseases characterized by cell death involving kidney papilla in the kidney medulla. Damages to this area may hinder the kidney to concentrate urine resulting in polyuria. Sloughed off necrotic tissue may block kidney pelvis or ureter. Necrosis of multiple renal papillae can lead to kidney failure." []
synonym: "Kidney Papillary Necrosis" EXACT []
synonym: "Necrotising Renal Papillitis" EXACT []
synonym: "Necrotizing Renal Papillitis" EXACT []
synonym: "Papillary Necrosis" EXACT []
synonym: "Papillary Necrosis (Disorder)" EXACT []
synonym: "Renal Papillitis Necrotizing" EXACT []
xref: EFO:1001004
is_a: HP:0000077 ! Abnormality of the Kidney
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO_1001004 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009445 xsd:string

[Term]
id: SCDO:0009488
name: obsolete Molecule
def: "'Any single chemical entity that is an electrically neutral entity consisting of more than one atom. Each atom carries a certain number of electrons that orbit around the nucleus.[Curator team: []]'" []
xref: CHEBI:25367
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/CHEBI_25367 xsd:string
is_obsolete: true

[Term]
id: SCDO:0009532
name: Beneficence
def: "Effort made to secure the well-being of persons, maximizing possible benefits and minimizing possible harms." []
xref: MESH:D026686
is_a: GSSO:003239 ! Ethical Principle
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000340 https://www.hhs.gov/ohrp/sites/default/files/the-belmont-report-508c_FINAL.pdf xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:0009613
name: Protein Phenotype
def: "The physical characteristics and levels of proteins that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." []
is_a: SCDO:0009884 ! Biochemical Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into BioAssay Ontology below \"biochemical phenotype\".\n\nCan all sub-classes of the \"Gene Product\" class not be included here?\n\nCan this class not be removed but its sub-classes kept?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0009620
name: deprecated Low Reticulocyte Count
def: "An abnormally low number of reticulocytes per unit volume of blood." []
is_a: SCDO:0000359 ! deprecated terms
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://en.wikipedia.org/wiki/Reticulocyte
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nSymptom of aplastic crisis, possibly due to parvovirus B19 infection. Is there a certain value below which is considered a low reticulocyte count?" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string
is_obsolete: true
replaced_by: SCDO:0001423

[Term]
id: SCDO:0009635
name: deprecated Aplastic Crises
def: "'The aplastic crisis is temporary cessation of red cell production. This usually affect sickle cell patients, because of the markedly shortened red cell survival time in patients with sickle cell disease, a precipitous drop in hemoglobin occurs in the absence of adequate reticulocytosis. [Curator team: []]'" []
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000340 http://www.ihtc.org/medical-professionals/blood-disorders/sickle-cell-disease/aplastic-crisis-intervention/ xsd:string
is_obsolete: true
replaced_by: SCDO:0006847

[Term]
id: SCDO:0009664
name: Abdominal Vaso-Occlusive Crisis
def: "Pain resulting from tissue ischemia as a result of blockage of mesenteric blood vessels." []
is_a: SCDO:0001229 ! Vaso-Occlusive Crisis
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000153 ! in guideline Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Akingbola TS, Kolude B, Aneni EC, et al. ABDOMINAL PAIN IN ADULT SICKLE CELL DISEASE PATIENTS: A NIGERIAN EXPERIENCE. Annals of Ibadan Postgraduate Medicine. 2011;9(2):100-104." xsd:string
property_value: SCDO:0000340 "SCD Management guidelines - Tanzania" xsd:string
property_value: SCDO:0000662 "Abdominal distension with generalised abdominal tenderness (no rebound tenderness) and reduced bowel sounds. Abdomen moves with respiration. Vomiting/diarrhoea are not common." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0009731
name: Beta Thalassemia Mutation
def: "A mutation in the beta-globin gene, HBB, that causes decreased or absent beta-globin synthesis." []
is_a: IDOMAL:50000026 ! Mutation
relationship: RO:0003303 SCDO:0000114 ! causes condition Beta Thalassemia Trait
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0009786
name: Other HBB Variants
def: "A genetic mutation in the HBB gene that results in absent or decreased hemoglobin subunit beta or an abnormal hemoglobin other than Hb S." []
is_a: SCDO:1000038 ! SCD Causal Mutation
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Too specific to SCD to be included in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0009884
name: Biochemical Phenotype
def: "The proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment." []
xref: BAO:0170003
is_a: SCDO:0007623 ! Molecular Phenotype
property_value: SCDO:0000340 "details"
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0009884 xsd:string

[Term]
id: SCDO:0010000
name: obsolete Other Genotypes
def: "'Genotypes which are not specific to sickle cell trait.'" []
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true

[Term]
id: SCDO:0300002
name: Research Ethics
def: "The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic." []
xref: MESH:D032984
is_a: NCIT:C39796 ! Ethics
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D032984 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0300002 xsd:string

[Term]
id: SCDO:0300003
name: Publication Formats
def: "Specific genre of publication." []
xref: MESH:D052180
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D052180 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0300003 xsd:string

[Term]
id: SCDO:0300004
name: Epidemiologic Study Characteristics
def: "Types and formulations of studies used in epidemiological and clinical research." []
xref: MESH:D016020
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000303 "Suggest update to description in MESH" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016020 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:0300005
name: Research Characteristics
def: "Elements, types, descriptions and formulations of a research study." []
is_a: SCDO:0006339 ! Research
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Gaston K. Mazandu)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:0300006
name: Information Disclosure
def: "Revealing of information, by oral or written communication." []
xref: MESH:D030881
is_a: SCDO:0002125 ! Confidentiality
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D030881 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0300006 xsd:string

[Term]
id: SCDO:0300007
name: Parental Notification
def: "Reporting to parents or guardians about care to be provided to a minor (minors)." []
xref: MESH:D035622
is_a: SCDO:0300006 ! Information Disclosure
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D035622 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0300007 xsd:string

[Term]
id: SCDO:0300008
name: Mandatory Reporting
def: "A legal requirement that designated types of information acquired by professionals or institutions in the course of their work be reported to appropriate authorities." []
xref: MESH:D019221
is_a: SCDO:0300006 ! Information Disclosure
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D019221 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0300008 xsd:string

[Term]
id: SCDO:0300009
name: Data Anonymization
def: "Making information permanently non-identifiable that is associated with the identity of specific entities via encryption or other methods." []
synonym: "Data De-Identification" EXACT []
synonym: "Data Masking" EXACT []
synonym: "De-Identification" EXACT []
xref: MESH:D000068240
is_a: SCDO:0002125 ! Confidentiality
property_value: SCDO:0000303 "Suggest update to description in MESH" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000068240 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000000
name: Acute Phenotype
def: "An observable characteristic of disease that has a severe and rapid onset of symptoms with short duration." []
is_a: HP:0000118 ! Abnormal Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C14140 xsd:string
property_value: SCDO:0000340 http://semanticscience.org/resource/SIO_010056 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000001
name: deprecated Research Subject ID
def: "A unique identifier generated either manually or electronically when adding a subject to a study." []
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true
replaced_by: SCDO:1000469

[Term]
id: SCDO:1000004
name: Renal Replacement Therapy
def: "Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys." []
xref: MESH:D017582
is_a: SCDO:0001129 ! Supportive Therapeutics
relationship: SCDO:1000018 HP:0000084 ! treats Kidney Failure
relationship: SCDO:1000018 HP:0009045 ! treats Exercise-Induced Rhabdomyolysis
property_value: SCDO:0000303 "Could this and it's sub-classes not fall below any of the other main Therapeutics classes? Symptomatic?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D017582 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000004 xsd:string

[Term]
id: SCDO:1000007
name: Hemoglobin D
def: "An abnormal hemoglobin caused by various point mutations within the HBB gene. This form of hemoglobin prevents red blood cells from carrying oxygen effectively. There are at least 8 different types of hemoglobin D." []
synonym: "Haemoglobin D" EXACT []
synonym: "Hb D" EXACT []
synonym: "HbD" EXACT []
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:1000108 ! has causal or contributing genetic variation HBB, SER9TYR
relationship: SCDO:1000210 SCDO:1000109 ! has causal or contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000210 SCDO:1000110 ! has causal or contributing genetic variation HBB, GLY16ARG
relationship: SCDO:1000210 SCDO:1000111 ! has causal or contributing genetic variation HBB, ASN19LYS
relationship: SCDO:1000210 SCDO:1000112 ! has causal or contributing genetic variation HBB, GLU22GLN
relationship: SCDO:1000210 SCDO:1000113 ! has causal or contributing genetic variation HBB, GLU22VAL
relationship: SCDO:1000210 SCDO:1000114 ! has causal or contributing genetic variation HBB, THR87LYS
relationship: SCDO:1000210 SCDO:1000115 ! has causal or contributing genetic variation HBB, GLU121ALA
property_value: SCDO:0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"." xsd:string
property_value: SCDO:0000340 https://newbornscreeningcodes.nlm.nih.gov/nb/sc/condition/Hb-F-S-D
property_value: SCDO:0000340 https://www.sciencedirect.com/science/article/pii/S1516848415000316
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000008
name: Hemoglobin M
def: "A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha, beta or gamma chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis." []
synonym: "Hb M" EXACT []
synonym: "HbM Hemoglobin" EXACT []
xref: MESH:D006449
is_a: SCDO:0003807 ! Abnormal Hemoglobin
property_value: SCDO:0000303 "Suggest update to description in MESH (to include \"gamma chains\")\nSuggest this term replaces \"Methemoglobinemia\" below \"Abnormal Hemoglobin\" in the HPO." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006449 xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000009
name: Hemoglobin E
def: "An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations." []
synonym: "Hb E" EXACT []
xref: MESH:D006446
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:1000042 ! has causal or contributing genetic variation HBB, GLU26LYS
property_value: SCDO:0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\", for the sake of completion." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006446 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000009 xsd:string

[Term]
id: SCDO:1000010
name: Sickle Cell Disease-S/HPFH
def: "A group of disorders caused by large deletions of the beta-globin gene complex; typically 30% fetal haemoglobin." []
synonym: "Hereditary Persistence of Fetal Hemoglobin-Sickle Cell Disease Syndrome" EXACT []
synonym: "HPFH-Sickle Cell Disease Syndrome" EXACT []
synonym: "Sickle Cell Disease Syndrome-Hereditary Persistence of Fetal Hemoglobin" EXACT []
synonym: "Sickle Cell Disease-S/Persistence of Fetal Hemoglobin" EXACT []
synonym: "Sickle Cell-Hereditary Persistence of Fetal Hemoglobin" EXACT []
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
is_a: SCDO:1000215 ! Structural and Quantitative Hemoglobinopathy
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0003894 ! diagnosed using tool Gap PCR
relationship: SCDO:1000172 SCDO:1000069 ! has causal genotype Hemoglobin Genotype S/HPFH
relationship: SCDO:1000210 SCDO:0006860 ! has causal or contributing genetic variation HBG1 and/or HBG2 Mutations
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000063 ! has causal or contributing genetic variation HBB, 106-KB DEL
relationship: SCDO:1000218 HP:0001744 ! has manifestation Splenomegaly
relationship: SCDO:1000218 HP:0010885 ! has manifestation Osteonecrosis
relationship: SCDO:1000223 HP:0011904 ! has causal molecular phenotype Increased Hemoglobin F
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000012
name: Beta-Globin Family Members
def: "Members of the beta-globin family. In humans, they are encoded in a gene cluster on chromosome 11. They include hemoglobin subunit epsilon, hemoglobin subunit gamma, hemoglobin subunit delta and hemoglobin subunit beta. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult hemoglobin is comprised of two alpha globin chains and two beta-globin chains." []
synonym: "Beta-Globins" EXACT []
xref: MESH:D055544
is_a: SCDO:0005339 ! Globin Phenotype
is_a: SCDO:1000104 ! Hemoglobin Subunits
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055544
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000012 xsd:string

[Term]
id: SCDO:1000013
name: HBB
def: "This gene encodes the hemoglobin subunit beta and is located on chromosome 11 mapped at 11p15.5." []
synonym: "Beta-Globin Gene" EXACT []
synonym: "HBB Gene" EXACT []
synonym: "HBB1" EXACT []
synonym: "Hemoglobin Beta Gene" EXACT []
synonym: "Hemoglobin Beta Locus" EXACT []
synonym: "Hemoglobin Subunit Beta Gene" EXACT []
xref: NCBIGene:3043
is_a: SCDO:1000362 ! Beta-Globin Gene
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/GEXO?p=classes&conceptid=http%3A%2F%2Fidentifiers.org%2Fncbigene%2F3043
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000014
name: HBD
def: "This gene encodes the hemoglobin subunit delta, which is a component of hemoglobin A2, which plays a role in the transport of oxygen to tissues of the adult body, but exists only in small amounts in all adult humans (1.5-3.1% of all hemoglobin molecules)." []
synonym: "HBD Gene" EXACT []
synonym: "Hemoglobin Delta Gene" EXACT []
synonym: "Hemoglobin Subunit Delta Gene" EXACT []
xref: NCIT:C84961
is_a: SCDO:1000362 ! Beta-Globin Gene
property_value: SCDO:0000303 "Suggest update to description in NCIT" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/NCIT_C84961 xsd:string
property_value: SCDO:0000340 https://en.wikipedia.org/wiki/HBD
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000016
name: Hemoglobin O-Arab
def: "An abnormal hemoglobin that results from the substitution of glutamic acid with lysine at position 121 of the beta chain." []
synonym: "Hb O-Arab" EXACT []
synonym: "Hb-Arab" EXACT []
synonym: "Hemoglobin-Arab" EXACT []
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:1000040 ! has causal or contributing genetic variation HBB, GLU121LYS
property_value: SCDO:0000303 "Request inclusion in the HPO, below \"Abnormal Hemoglobin\"." xsd:string
property_value: SCDO:0000340 "MESH and Zimmerman SA. Am J Hematol. 1999 Apr; 60(4) 279-84" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000017
name: Surgery
def: "A material processing technique that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury or to help improve bodily function or appearance." []
xref: ERO:0000378
is_a: SCDO:0001133 ! Symptomatic Therapeutics
relationship: SCDO:1000018 DOID:1188 ! treats Mononeuropathy
relationship: SCDO:1000018 HP:0000815 ! treats Hypergonadotropic Hypogonadism
relationship: SCDO:1000018 HP:0000962 ! treats Hyperkeratosis
relationship: SCDO:1000018 HP:0001260 ! treats Dysarthria
relationship: SCDO:1000018 HP:0001342 ! treats Cerebral Hemorrhage
relationship: SCDO:1000018 HP:0001920 ! treats Renal Artery Stenosis
relationship: SCDO:1000018 HP:0002138 ! treats Subarachnoid Hemorrhage
relationship: SCDO:1000018 HP:0002164 ! treats Nail Dysplasia
relationship: SCDO:1000018 HP:0002170 ! treats Intracranial Hemorrhage
relationship: SCDO:1000018 HP:0002341 ! treats Cervical Cord Compression
relationship: SCDO:1000018 HP:0002650 ! treats Scoliosis
relationship: SCDO:1000018 HP:0002653 ! treats Bone Pain
relationship: SCDO:1000018 HP:0002665 ! treats Lymphoma
relationship: SCDO:1000018 HP:0002808 ! treats Kyphosis
relationship: SCDO:1000018 HP:0003302 ! treats Spondylolisthesis
relationship: SCDO:1000018 HP:0003418 ! treats Back Pain
relationship: SCDO:1000018 HP:0009830 ! treats Peripheral Neuropathy
relationship: SCDO:1000018 HP:0010628 ! treats Facial Nerve Palsy
relationship: SCDO:1000018 HP:0010885 ! treats Osteonecrosis
relationship: SCDO:1000018 HP:0011868 ! treats Sciatica
relationship: SCDO:1000018 HP:0011886 ! treats Hyphema
relationship: SCDO:1000018 HP:0012203 ! treats Onychomycosis
relationship: SCDO:1000018 HP:0030049 ! treats Brain Abscess
relationship: SCDO:1000018 HP:0030127 ! treats Endometriosis
relationship: SCDO:1000018 HP:0100774 ! treats Hyperostosis
relationship: SCDO:1000018 NCIT:C115319 ! treats Ophthalmologic Complication
relationship: SCDO:1000018 OBI:1110053 ! treats Cancer
relationship: SCDO:1000018 SCDO:0000454 ! treats Glaucoma (Secondary to Presence of Blood in the Anterior Chamber of the Eye)
relationship: SCDO:1000018 SCDO:0000656 ! treats Intracranial Hypotension
relationship: SCDO:1000018 SCDO:0000840 ! treats Osteomyelitis
relationship: SCDO:1000018 SCDO:0001168 ! treats Transient Monocular Blindness
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/ERO_0000378 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000017 xsd:string

[Term]
id: SCDO:1000020
name: Treatment of Precipitating Factors
def: "Treatment of factors associated with the definitive onset of a disease, illness, accident, behavioral response, or course of action. Usually one factor is more important or more obviously recognizable than others, if several are involved, and one may often be regarded as necessary. Examples include exposure to specific disease; amount or level of an infectious organism, drug, or noxious agent, etc." []
synonym: "Management of Precipitating Factors" EXACT []
synonym: "Management of Underlying Cause" EXACT []
synonym: "Treatment of Underlying Cause" EXACT []
is_a: SCDO:0001152 ! Therapeutics
relationship: SCDO:1000018 DOID:1188 ! treats Mononeuropathy
relationship: SCDO:1000018 HP:0000084 ! treats Kidney Failure
relationship: SCDO:1000018 HP:0000096 ! treats Glomerulosclerosis
relationship: SCDO:1000018 HP:0000099 ! treats Glomerulonephritis
relationship: SCDO:1000018 HP:0000123 ! treats Nephritis
relationship: SCDO:1000018 HP:0000815 ! treats Hypergonadotropic Hypogonadism
relationship: SCDO:1000018 HP:0000823 ! treats Delayed Puberty
relationship: SCDO:1000018 HP:0000843 ! treats Hyperparathyroidism
relationship: SCDO:1000018 HP:0000952 ! treats Jaundice
relationship: SCDO:1000018 HP:0000961 ! treats Cyanosis
relationship: SCDO:1000018 HP:0000967 ! treats Petechiae
relationship: SCDO:1000018 HP:0000980 ! treats Pallor
relationship: SCDO:1000018 HP:0001271 ! treats Polyneuropathy
relationship: SCDO:1000018 HP:0001298 ! treats Encephalopathy
relationship: SCDO:1000018 HP:0001511 ! treats Intrauterine Growth Restriction
relationship: SCDO:1000018 HP:0001789 ! treats Hydrops Fetalis
relationship: SCDO:1000018 HP:0001970 ! treats Interstitial Nephritis
relationship: SCDO:1000018 HP:0002007 ! treats Frontal Bossing
relationship: SCDO:1000018 HP:0002157 ! treats Azotaemia
relationship: SCDO:1000018 HP:0002829 ! treats Arthralgia
relationship: SCDO:1000018 HP:0002955 ! treats Granulomatosis
relationship: SCDO:1000018 HP:0003198 ! treats Myopathy
relationship: SCDO:1000018 HP:0003418 ! treats Back Pain
relationship: SCDO:1000018 HP:0003641 ! treats Hemoglobinuria
relationship: SCDO:1000018 HP:0007340 ! treats Leg Weakness
relationship: SCDO:1000018 HP:0009830 ! treats Peripheral Neuropathy
relationship: SCDO:1000018 HP:0010628 ! treats Facial Nerve Palsy
relationship: SCDO:1000018 HP:0011001 ! treats Increased Bone Mineral Density
relationship: SCDO:1000018 HP:0012282 ! treats Morbilliform Rash
relationship: SCDO:1000018 MP:0001762 ! treats Diuresis
relationship: SCDO:1000018 MP:0001792 ! treats Impaired Wound Healing
relationship: SCDO:1000018 NCIT:C115319 ! treats Ophthalmologic Complication
relationship: SCDO:1000018 NCIT:C26702 ! treats Ataxia
relationship: SCDO:1000018 SCDO:0000037 ! treats Albuminuria
relationship: SCDO:1000018 SCDO:0000265 ! treats Coma
relationship: SCDO:1000018 SCDO:0000465 ! treats Growth Delay
relationship: SCDO:1000018 SCDO:0000743 ! treats Membranous Nephropathy
relationship: SCDO:1000018 SCDO:0000796 ! treats Nephrotic Syndrome
relationship: SCDO:1000018 SCDO:0000797 ! treats Nephrotic Range Proteinuria
relationship: SCDO:1000018 SCDO:0000828 ! treats Oliguria
relationship: SCDO:1000018 SCDO:0000839 ! treats Osteomalacia
relationship: SCDO:1000018 SCDO:0000851 ! treats Pain
relationship: SCDO:1000018 SCDO:0000932 ! treats Proteinuria
relationship: SCDO:1000018 SCDO:0000986 ! treats Renal Tubular Acidosis
relationship: SCDO:1000018 SCDO:0001105 ! treats Steroid-Resistant Nephrotic Syndrome
relationship: SCDO:1000018 SCDO:0001168 ! treats Transient Monocular Blindness
relationship: SCDO:1000018 SCDO:1000224 ! treats Easy Bruisability
relationship: SCDO:1000018 SYMP:0019161 ! treats Muscle Pain
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D015985 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000023
name: obsolete Evidence Code
def: "'Every annotation must be attributed to a source, which may be a literature reference, another database or a computational analysis. The annotation must indicate what kind of evidence is found in the cited source to support the association between the gene product and the GO term. A simple controlled vocabulary is used to record evidence; and the evidence codes are simply the three-letter codes used to signify the type of evidence cited. [Curator team: Exact []]'" []
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "The information in this class and its sub-classes will be migrated to evidence code properties." xsd:string
property_value: SCDO:0000340 http://www.geneontology.org/faq/what-evidence-code xsd:string
is_obsolete: true

[Term]
id: SCDO:1000024
name: obsolete IEA (inferred from electronic annotation)
def: "'Used for annotations that depend directly on computation or automated transfer of annotations from a database, particularly when the analysis is performed internally and not published. A key feature that distinguishes this evidence code from others is that it is not made by a curator; use IEA when no curator has checked the specific annotation to verify its accuracy. [Curator team: Exact []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
property_value: SCDO:0000340 http://geneontology.org/page/automatically-assigned-evidence-codes xsd:string
is_obsolete: true

[Term]
id: SCDO:1000025
name: obsolete PCS (published clinical study)
def: "'This should be used for information extracted from articles in the medical literature. [Curator team: []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
is_obsolete: true

[Term]
id: SCDO:1000026
name: obsolete ICE (individual clinical experience)
def: "'Can be used for annotations based on individual clinical experience. [Curator team: []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
is_obsolete: true

[Term]
id: SCDO:1000027
name: obsolete ITM (inferred by text-mining)
def: "'Not described [Curator team: []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
is_obsolete: true

[Term]
id: SCDO:1000028
name: obsolete TAS (traceable author statement)
def: "'Usually reviews or disease entries (e.g. OMIM) that only refers to the original publication. [Curator team: []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
is_obsolete: true

[Term]
id: SCDO:1000029
name: obsolete NAS (non-traceable author statement)
def: "'used in all cases where the author makes a statement that a curator wants to capture but for which there are neither results presented nor a specific reference cited in the source used to make the annotation. [Curator team: []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
property_value: SCDO:0000340 http://www.geneontology.org/page/nas-non-traceable-author-statement xsd:string
is_obsolete: true

[Term]
id: SCDO:1000030
name: obsolete IC (inferred by curator)
def: "'Used for those cases where an annotation is not supported by any direct evidence, but can be reasonably inferred by a curator from other annotations, for which evidence is available. [Curator team: []]'" []
is_a: SCDO:1000023 ! obsolete Evidence Code
property_value: SCDO:0000340 http://www.geneontology.org/page/ic-inferred-curator xsd:string
is_obsolete: true

[Term]
id: SCDO:1000031
name: from personal attribute
def: "Terms deprecated in the \"Personal Attribute\" class." []
is_a: SCDO:0000359 ! deprecated terms

[Term]
id: SCDO:1000032
name: Diagnostic Tool
def: "A diagnostic instrument, technique, laboratory assay or test, or method of patient examination used for differential diagnosis." []
is_a: SCDO:0000379 ! Diagnostics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000033
name: Diagnostic Instrument
def: "A research instrument consisting of a series of questions and other prompts for the purpose of gathering information from respondents to assist with differential diagnosis." []
synonym: "Diagnostic Questionnaire" EXACT []
is_a: SCDO:1000032 ! Diagnostic Tool
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Questionnaire xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000034
name: from diagnostics
def: "Terms deprecated in the \"Diagnostics\" class." []
is_a: SCDO:0000359 ! deprecated terms

[Term]
id: SCDO:1000035
name: from therapeutics
def: "Terms deprecated in the \"Therapeutics\" class." []
is_a: SCDO:0000359 ! deprecated terms

[Term]
id: SCDO:1000036
name: Hemoglobin C Present
def: "When the abnormal hemoglobin, hemoglobin C (HbC), has been detected in a blood sample." []
synonym: "Haemoglobin C in Blood" EXACT []
synonym: "Haemoglobin C Present" EXACT []
synonym: "HbC in Blood" EXACT []
synonym: "HbC Present" EXACT []
synonym: "Hemoglobin C in Blood" EXACT []
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000037
name: Abnormality of the Cerebral Vasculature
def: "An abnormality of the cerebral vasculature." []
synonym: "Abnormality of the Cerebral Blood Vessels" EXACT []
synonym: "Cerebrovascular Disorder" EXACT []
xref: HP:0100659
is_a: HP:0002597 ! Abnormality of the Vasculature
property_value: SCDO:0000340 HP:0100659
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000038
name: SCD Causal Mutation
def: "A mutation wholly or partly responsible for causing a sickle cell disease." []
is_a: IDOMAL:50000026 ! Mutation
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nB-Thal mutations:  -- http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2004.tb00278.x/pdf -- https://www.ncbi.nlm.nih.gov/pubmed/15153712" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000039
name: HBB, GLU6VAL
def: "The glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine." []
synonym: "Beta S Mutation" EXACT []
synonym: "E6V" EXACT []
synonym: "Glu6Val" EXACT []
synonym: "Sickle Cell Mutation" EXACT []
is_a: SCDO:1000038 ! SCD Causal Mutation
relationship: RO:0003302 NCIT:C131682 ! causes or contributes to condition Sickle Cell Disease-SS
relationship: RO:0003302 SCDO:0001055 ! causes or contributes to condition Sickle Cell Trait
relationship: RO:0003302 SCDO:0001059 ! causes or contributes to condition Sickle Cell Disease-SC
relationship: RO:0003302 SCDO:0001061 ! causes or contributes to condition Sickle Cell Disease-S/D-Punjab
relationship: RO:0003302 SCDO:0001062 ! causes or contributes to condition Sickle Cell Disease-SE
relationship: RO:0003302 SCDO:0001063 ! causes or contributes to condition Sickle Cell Disease-S/Lepore Boston
relationship: RO:0003302 SCDO:0001064 ! causes or contributes to condition Sickle Cell Disease-S/O-Arab
relationship: RO:0003302 SCDO:1000010 ! causes or contributes to condition Sickle Cell Disease-S/HPFH
relationship: RO:0003302 SCDO:1000062 ! causes or contributes to condition Sickle Cell Disease-S/C-Harlem
relationship: RO:0003302 SCDO:1000086 ! causes or contributes to condition Sickle Cell Disease-S/Quebec Chori
relationship: RO:0003302 SCDO:1000090 ! causes or contributes to condition Sickle Cell Disease-S/S-South End
relationship: RO:0003302 SCDO:1000164 ! causes or contributes to condition Sickle Cell Disease A/Jamaica Plain
relationship: RO:0003302 SCDO:1000165 ! causes or contributes to condition Sickle Cell Disease A/S-Oman
relationship: RO:0003302 SCDO:1000166 ! causes or contributes to condition Sickle Cell Disease C/S Antilles
relationship: RO:0003302 SCDO:1000205 ! causes or contributes to condition Hemoglobin C-Harlem Disease
relationship: SCDO:1000184 SCDO:1000049 ! contributes to genotype Hemoglobin Genotype SC
relationship: SCDO:1000184 SCDO:1000050 ! contributes to genotype Hemoglobin Genotype S/D-Punjab
relationship: SCDO:1000184 SCDO:1000051 ! contributes to genotype Hemoglobin Genotype S/O-Arab
relationship: SCDO:1000184 SCDO:1000052 ! contributes to genotype Hemoglobin Genotype SE
relationship: SCDO:1000184 SCDO:1000053 ! contributes to genotype Hemoglobin Genotype SS
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000056 ! contributes to genotype Hemoglobin Genotype S/C-Harlem
relationship: SCDO:1000184 SCDO:1000067 ! contributes to genotype Hemoglobin Genotype S/Beta Zero Thalassaemia
relationship: SCDO:1000184 SCDO:1000069 ! contributes to genotype Hemoglobin Genotype S/HPFH
relationship: SCDO:1000184 SCDO:1000070 ! contributes to genotype Hemoglobin Genotype S/Lepore Boston
relationship: SCDO:1000184 SCDO:1000071 ! contributes to genotype Hemoglobin Genotype A/Jamaica Plain
relationship: SCDO:1000184 SCDO:1000075 ! contributes to genotype Hemoglobin Genotype A/S-Oman
relationship: SCDO:1000184 SCDO:1000081 ! contributes to genotype Hemoglobin Genotype C/S Antilles
relationship: SCDO:1000184 SCDO:1000084 ! contributes to genotype Hemoglobin Genotype S/Quebec-Chori
relationship: SCDO:1000184 SCDO:1000088 ! contributes to genotype Hemoglobin Genotype S/S-South End
relationship: SCDO:1000184 SCDO:1000107 ! contributes to genotype Hemoglobin Genotype S/Beta Thalassemia
relationship: SCDO:1000184 SCDO:1000159 ! contributes to genotype Hemoglobin Genotype S/Beta Minus Thalassaemia
relationship: SCDO:1000184 SCDO:1000161 ! contributes to genotype Hemoglobin Genotype AS
relationship: SCDO:1000217 SCDO:0000514 ! causes or contributes to molecular phenotype Hemoglobin S
relationship: SCDO:1000217 SCDO:1000058 ! causes or contributes to molecular phenotype Hemoglobin C-Harlem
relationship: SCDO:1000217 SCDO:1000072 ! causes or contributes to molecular phenotype Hemoglobin Jamaica Plain
relationship: SCDO:1000217 SCDO:1000073 ! causes or contributes to molecular phenotype Hemoglobin S-Antilles
relationship: SCDO:1000217 SCDO:1000074 ! causes or contributes to molecular phenotype Hemoglobin S-Oman
relationship: SCDO:1000217 SCDO:1000083 ! causes or contributes to molecular phenotype Hemoglobin S-South End
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.bloodjournal.org/content/bloodjournal/46/3/363.full.pdf?sso-checked=true xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000040
name: HBB, GLU121LYS
def: "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation is found as a single alteration in Hemoglobin O-Arab and is one of the two contributing mutations to the production of Hemoglobin S-Oman." []
synonym: "Beta O-Arab Mutation" EXACT []
synonym: "Contributing Beta S-Oman Mutation" EXACT []
synonym: "Glu121Lys" EXACT []
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:0000544 ! causes or contributes to condition Hemoglobin O-Arab Disease
relationship: RO:0003302 SCDO:0000545 ! causes or contributes to condition Hemoglobin O-Arab Trait
relationship: RO:0003302 SCDO:0001064 ! causes or contributes to condition Sickle Cell Disease-S/O-Arab
relationship: RO:0003302 SCDO:1000165 ! causes or contributes to condition Sickle Cell Disease A/S-Oman
relationship: SCDO:1000184 SCDO:1000051 ! contributes to genotype Hemoglobin Genotype S/O-Arab
relationship: SCDO:1000184 SCDO:1000075 ! contributes to genotype Hemoglobin Genotype A/S-Oman
relationship: SCDO:1000184 SCDO:1000228 ! contributes to genotype Hemoglobin Genotype AO-Arab
relationship: SCDO:1000184 SCDO:1000231 ! contributes to genotype Hemoglobin Genotype O-Arab
relationship: SCDO:1000217 SCDO:1000016 ! causes or contributes to molecular phenotype Hemoglobin O-Arab
relationship: SCDO:1000217 SCDO:1000074 ! causes or contributes to molecular phenotype Hemoglobin S-Oman
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0202"
property_value: SCDO:0000340 "0245"
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000041
name: HBB, GLU6LYS
def: "A mutation where the glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation results in the production of Hemoglobin C and confers resistance to malaria." []
synonym: "Beta C mutation" EXACT []
synonym: "HbC Mutation" EXACT []
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:0000519 ! causes or contributes to condition Hemoglobin C Disease
relationship: RO:0003302 SCDO:0000520 ! causes or contributes to condition Hemoglobin C Trait
relationship: RO:0003302 SCDO:0001059 ! causes or contributes to condition Sickle Cell Disease-SC
relationship: RO:0003302 SCDO:1000166 ! causes or contributes to condition Sickle Cell Disease C/S Antilles
relationship: SCDO:1000184 SCDO:1000049 ! contributes to genotype Hemoglobin Genotype SC
relationship: SCDO:1000184 SCDO:1000081 ! contributes to genotype Hemoglobin Genotype C/S Antilles
relationship: SCDO:1000184 SCDO:1000225 ! contributes to genotype Hemoglobin Genotype AC
relationship: SCDO:1000184 SCDO:1000232 ! contributes to genotype Hemoglobin Genotype CC
relationship: SCDO:1000217 SCDO:0000513 ! causes or contributes to molecular phenotype Hemoglobin C
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0038"
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000042
name: HBB, GLU26LYS
def: "A mutation in the HBB gene causing substitution of glutamic acid for lysine at the 26th position of the beta-globin chain." []
synonym: "Beta E Mutation" EXACT []
synonym: "HbE Mutation" EXACT []
is_a: SCDO:0001765 ! Beta-Minus Thalassemia Mutation
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:0000531 ! causes or contributes to condition Hemoglobin E Trait
relationship: RO:0003302 SCDO:0001062 ! causes or contributes to condition Sickle Cell Disease-SE
relationship: SCDO:1000184 SCDO:1000052 ! contributes to genotype Hemoglobin Genotype SE
relationship: SCDO:1000184 SCDO:1000227 ! contributes to genotype Hemoglobin Genotype AE
relationship: SCDO:1000184 SCDO:1000229 ! contributes to genotype Hemoglobin Genotype EE
relationship: SCDO:1000217 SCDO:1000009 ! causes or contributes to molecular phenotype Hemoglobin E
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0071"
property_value: SCDO:0000340 http://www.orpha.net/data/patho/GB/uk-HbE.pdf
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000043
name: Gender Identity
def: "A person's concept of self as being male and masculine or female and feminine, or ambivalent, based in part on physical characteristics, parental responses, and psychological and social pressures. It is the internal experience of gender role." []
xref: MESH:D005783
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D005783
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000043 xsd:string

[Term]
id: SCDO:1000044
name: HBB, ASP73ASN
def: "A mutation where the aspartic acid in position 73 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation is found as a single alteration in Hemoglobin Korle Bu and is one of the two contributing mutations to the production of Hemoglobin C-Harlem." []
synonym: "Asp73Asn" EXACT []
synonym: "D73N" EXACT []
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:1000062 ! causes or contributes to condition Sickle Cell Disease-S/C-Harlem
relationship: RO:0003302 SCDO:1000205 ! causes or contributes to condition Hemoglobin C-Harlem Disease
relationship: SCDO:1000184 SCDO:1000056 ! contributes to genotype Hemoglobin Genotype S/C-Harlem
relationship: SCDO:1000217 SCDO:1000058 ! causes or contributes to molecular phenotype Hemoglobin C-Harlem
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.bloodjournal.org/content/bloodjournal/46/3/363.full.pdf?sso-checked=true xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000045
name: HBB, VAL23ILE
def: "A mutation where the valine in position 23 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. When compounded with the HbS mutation in the same gene, the sickling Hemoglobin S-Antilles is produced." []
synonym: "Contributing Beta S-Antilles Mutation" EXACT []
synonym: "Contributing Hb S-Antilles Mutation" EXACT []
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:1000166 ! causes or contributes to condition Sickle Cell Disease C/S Antilles
relationship: SCDO:1000184 SCDO:1000081 ! contributes to genotype Hemoglobin Genotype C/S Antilles
relationship: SCDO:1000217 SCDO:1000073 ! causes or contributes to molecular phenotype Hemoglobin S-Antilles
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0244"
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000046
name: HBB, THR87ILE
def: "A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. This mutation is found as a single alteration in Hemoglobin Quebec-Chori. Compound heterozygosity for Hb Quebec-chori and Hb S results in sickle cell disease." []
synonym: "Hb Quebec-Chori Mutation" EXACT []
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:1000086 ! causes or contributes to condition Sickle Cell Disease-S/Quebec Chori
relationship: SCDO:1000184 SCDO:1000084 ! contributes to genotype Hemoglobin Genotype S/Quebec-Chori
relationship: SCDO:1000217 SCDO:1000085 ! causes or contributes to molecular phenotype Hemoglobin Quebec Chori
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0403"
property_value: SCDO:0000340 "Witkowska, H. E., Lubin, B. H., Beuzard, Y., Baruchel, S., Esseltine, D. W., Vichinsky, E. P., Kleman, K. M., Bardakdjian-Michau, J., Pinkoski, L., Cahn, S., Roitman, E., Green, B. N., Falick, A. M., Shackleton, C. H. L. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. New Eng. J. Med. 325: 1150-1154, 1991." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000047
name: HBB, LEU68PHE
def: "A mutation where the leusine residue in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by phenylalanine. This mutation on its own produces a stable hemoglobin that does not result in hemolysis (Hb Rockford), but when in combination with the Hb S mutation (HBB, GLU6VAL), the symptomatic Hb Jamaica Plain is produced." []
synonym: "Contributing Hb Jamaica Plain Mutation" EXACT []
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:1000164 ! causes or contributes to condition Sickle Cell Disease A/Jamaica Plain
relationship: SCDO:1000184 SCDO:1000071 ! contributes to genotype Hemoglobin Genotype A/Jamaica Plain
relationship: SCDO:1000217 SCDO:1000072 ! causes or contributes to molecular phenotype Hemoglobin Jamaica Plain
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0524"
property_value: SCDO:0000340 "Perrault, J., Fairbanks, V. F., McCormick, D. J., Kubik, K., Madden, B. J., Holmes, M. W., Hoyer, J. D. Hemoglobin Rockford, beta68(E12)leu-to-phe: a new HB variant associated with mild anemia. (Abstract) Blood 90 (Suppl. 1): 30b, 1997." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000048
name: SCD Genotype
def: "The alleles, or variant forms of the HBB gene, that are carried by an SCD sufferer." []
synonym: "Sickle Cell Disease Genotype" EXACT []
synonym: "Sickle Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459467/
property_value: SCDO:0000303 "Probably too specific to be included in other ontologies.\n\nPaper mentioning haplotypes and severity: -- https://www.nature.com/scitable/topicpage/sickle-cell-anemia-a-look-at-global-8756219 --  -- Table of SCD Genotypes: -- http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2004.tb00278.x/pdf --  -- HBB allelic variants: -- https://www.omim.org/entry/141900#0243 --  -- Perhaps have parent class Hemoglobinopathy Genotype, with Hemoglobinopathy Trait below that?" xsd:string
property_value: SCDO:0000340 http://www.nature.com/scitable/definition/genotype-234 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000049
name: Hemoglobin Genotype SC
def: "The genotype when an individual has the Hb C gene from one parent and the Hb S gene from the other. Individuals with Hb SC have similar symptoms to individuals with Hb SS, however, the anemia is less severe." []
synonym: "beta6Glu>Val/beta6Glu>Lys" EXACT []
synonym: "Haemoglobin Genotype SC" EXACT []
synonym: "SC Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:0001059 ! causes condition Sickle Cell Disease-SC
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000041 ! has contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000222 SCDO:0000513 ! causes molecular phenotype Hemoglobin C
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/D006450
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000050
name: Hemoglobin Genotype S/D-Punjab
def: "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin D-Punjab (HBB Glu121Gln) variants." []
synonym: "beta6Glu>Val/beta121Glu>Gln" EXACT []
synonym: "Haemoglobin Genotype S/D-Punjab" EXACT []
synonym: "S/D-Punjab Genotype" EXACT []
is_a: SCDO:1000054 ! Hemoglobin Genotype SD
relationship: RO:0003303 SCDO:0001061 ! causes condition Sickle Cell Disease-S/D-Punjab
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000109 ! has contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:0000528 ! causes molecular phenotype Hemoglobin D-Punjab
property_value: SCDO:0000303 "Hemoglobin Genotype S/D-Punjab" xsd:string
property_value: SCDO:0000340 "Torres LS, Okumura JV, Silva DG, Bonini-Domingos CR. Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis. Rev Bras Hematol Hemoter. 2015;37(2): 120–126. pmid:25818823" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000051
name: Hemoglobin Genotype S/O-Arab
def: "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin O-Arab (HBB GluU121Lys) variants." []
synonym: "beta6Glu>Val/beta121Glu>Lys" EXACT []
synonym: "Haemoglobin Genotype S/OArab" EXACT []
synonym: "S/O-Arab Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:0001064 ! causes condition Sickle Cell Disease-S/O-Arab
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000040 ! has contributing genetic variation HBB, GLU121LYS
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000016 ! causes molecular phenotype Hemoglobin O-Arab
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Lancet. 2010 Dec 11;376(9757):2018-31. doi: 10.1016/S0140-6736(10)61029-X. Epub 2010 Dec 3." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000052
name: Hemoglobin Genotype SE
def: "Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin E (HBB Glu26Lys) variants." []
synonym: "beta6Glu>Val/beta26Glu>Lys" EXACT []
synonym: "Haemoglobin Genotype SE" EXACT []
synonym: "SE Genotype" EXACT []
synonym: "SE Hemoglobin Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:0001062 ! causes condition Sickle Cell Disease-SE
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000042 ! has contributing genetic variation HBB, GLU26LYS
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000009 ! causes molecular phenotype Hemoglobin E
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Lancet. 2010 Dec 11;376(9757):2018-31. doi: 10.1016/S0140-6736(10)61029-X. Epub 2010 Dec 3." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000053
name: Hemoglobin Genotype SS
def: "The homozygous genotype that involves a substitution of glutamic acid for a valine at position 6 of beta-globin chains produced by both beta-globin gene (HBB) alleles." []
synonym: "beta6Glu>Val/beta6Glu>Val" EXACT []
synonym: "Haemoglobin Genotype SS" EXACT []
synonym: "Hemoglobin S Genotype" EXACT []
synonym: "SS Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 NCIT:C131682 ! causes condition Sickle Cell Disease-SS
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000054
name: Hemoglobin Genotype SD
def: "Compound heterozygous inheritance of Hb S and Hb D mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb D generally results from substitution of glutamic acid for glutamine at beta-121 (beta121Glu>Gln); such as the Hb D-Punjab/Hb D-Los Angeles variants. There are several other Hb D variants, including Hb D-Iband where threonine is substituted by lysine at beta-87 (beta87Thr>Lys) and Hb D-Iran where glutamic acid is substituted by glutamine at beta-22 (beta22Glu>Gln)." []
synonym: "Haemoglobin Genotype SD" EXACT []
synonym: "SD Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 NCIT:C155310 ! causes condition Sickle Cell Disease-SD
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000108 ! has contributing genetic variation HBB, SER9TYR
relationship: SCDO:1000196 SCDO:1000109 ! has contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000196 SCDO:1000110 ! has contributing genetic variation HBB, GLY16ARG
relationship: SCDO:1000196 SCDO:1000111 ! has contributing genetic variation HBB, ASN19LYS
relationship: SCDO:1000196 SCDO:1000112 ! has contributing genetic variation HBB, GLU22GLN
relationship: SCDO:1000196 SCDO:1000113 ! has contributing genetic variation HBB, GLU22VAL
relationship: SCDO:1000196 SCDO:1000114 ! has contributing genetic variation HBB, THR87LYS
relationship: SCDO:1000196 SCDO:1000115 ! has contributing genetic variation HBB, GLU121ALA
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000007 ! causes molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://health.utah.gov/newbornscreening/Disorders/HB/Hb_SD_Disease_SD/FactSheet_Provider_HbSD_En.pdf
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000056
name: Hemoglobin Genotype S/C-Harlem
def: "Compound heterozygous inheritance of Hb S and Hb C-Harlem mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb C-Harlem involves two substitutions in each beta-chain: the first being identical to that found in Hb S, and the second being a substitution of aspartic acid at position 73 by asparagine (beta73Asp>Asn)." []
synonym: "beta6Glu>Val/beta6Glu>Val, beta73Asp>Asn" EXACT []
synonym: "Haemoglobin Genotype S/C-Harlem" EXACT []
synonym: "S/C-Harlem Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:1000062 ! causes condition Sickle Cell Disease-S/C-Harlem
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000044 ! has contributing genetic variation HBB, ASP73ASN
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000058 ! causes molecular phenotype Hemoglobin C-Harlem
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "PMID: 1148394" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000058
name: Hemoglobin C-Harlem
def: "An abnormal hemoglobin in which two mutations occur in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the aspartic acid in position 73 is replaced by asparagine." []
synonym: "HbS-HBC-Harlem" EXACT []
synonym: "Hemoglobin C-Georgetown" EXACT []
synonym: "Hemoglobin S-Hemoglobin C-Harlem" EXACT []
is_a: SCDO:1000082 ! Sickling Hemoglobin with Two Beta-Globin Gene Substitutions
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000044 ! has causal or contributing genetic variation HBB, ASP73ASN
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." xsd:string
property_value: SCDO:0000340 https://www.omim.org/entry/141900#0243 xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000059
name: Hemoglobin D-Punjab Trait
def: "The inheritance of the gene for hemoglobin D-Punjab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent." []
comment: Hemoglobin D-Punjab Trait causes no clinical or hematological alterations
synonym: "Hb AD-Punjab" EXACT []
is_a: SCDO:0000525 ! Hemoglobin D Trait
relationship: SCDO:1000210 SCDO:1000109 ! has causal or contributing genetic variation HBB, GLU121GLN
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382585/
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382585/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000060
name: SCD Molecular Phenotype
def: "The underlying molecular makeup resulting in sickle cell disease." []
is_a: SCDO:0007623 ! Molecular Phenotype
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Probably too specific to warrant inclusion into anther ontology.\n\nConsider inclusion of other sub-classes of this term in the Human Phenotype Ontology. -- - Elevated hemoglobin A1c -- - Imbalanced Hemoglobin Synthesis (and the 2 terms below this) -- Methemoglobina -- Others from MESH?: -- J, M, Methemoglobin?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000061
name: Altered Level of Normal Hemoglobin in SCD
def: "An altered level of normal hemoglobin (Hemoglobin A (Hb A), Hemoglobin A2 (Hb A2) or Hemoglobin F (Hb F, fetal hemoglobin) in the blood, which may be seen in those suffering with Sickle Cell Disease (SCD)." []
is_a: SCDO:1000276 ! Abnormal Hemoglobin Level in SCD
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably too specific to SCD be included in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000062
name: Sickle Cell Disease-S/C-Harlem
def: "A rare type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin C-Harlem. This condition is described to have a clinical course similar to sickle cell anemia." []
synonym: "SC(Harlem) Disease" EXACT []
synonym: "Sickle Cell-Hemoglobin C-Harlem Disease" EXACT []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0001364 HP:0000006 ! has mode of inheritance Autosomal Dominant
relationship: SCDO:1000172 SCDO:1000056 ! has causal genotype Hemoglobin Genotype S/C-Harlem
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000044 ! has causal or contributing genetic variation HBB, ASP73ASN
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000058 ! has causal molecular phenotype Hemoglobin C-Harlem
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Moo-Penn, W., Bechtel, K., Jue, D., Chan, M.S., Hopkins, G., Schneider, N.J., Wright, J. and Schmidt, R.M., 1975. The presence of hemoglobin S and C Harlem in an individual in the United States. Blood, 46(3), pp.363-367." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000063
name: HBB, 106-KB DEL
def: "A 106-kb deletion of the beta globin gene cluster." []
synonym: "HPFH1" EXACT []
is_a: SCDO:0004905 ! Beta-Globin Locus Deletion
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 NCIT:C129072 ! causes or contributes to condition Hereditary Persistence of Fetal Hemoglobin
relationship: RO:0003302 SCDO:1000010 ! causes or contributes to condition Sickle Cell Disease-S/HPFH
relationship: SCDO:1000015 SCDO:1000707 ! modifies Hemoglobin F Level
relationship: SCDO:1000184 SCDO:1000069 ! contributes to genotype Hemoglobin Genotype S/HPFH
relationship: SCDO:1000184 SCDO:1000235 ! contributes to genotype Hereditary Persistence of Fetal Hemoglobin Genotype
relationship: SCDO:1000217 HP:0011904 ! causes or contributes to molecular phenotype Increased Hemoglobin F
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0538"
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000064
name: Tiered Consent
def: "A consent model in which participants are given a set of options allowing them to select how they want to participate in the research." []
is_a: NCIT:C25460 ! Consent
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:0000340 https://www.genome.gov/27559022/informed-consent-glossary/ xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000065
name: Specific Consent
def: "Requires that consent to the use of human samples be specific to the 'purpose' for which the sample is to be used and that where previously collected samples are to be used for a different 'research purpose' further consent should generally be obtained." []
is_a: SCDO:0007087 ! Informed Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into the ICO below \"Informed Consent\"." xsd:string
property_value: SCDO:0000340 https://www.alrc.gov.au/publications/15-human-genetic-research-and-consent/specific-consent xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000066
name: Hemoglobin F Test
def: "The determination of the amount of hemoglobin F present in a sample." []
synonym: "Fetal Hemoglobin Test" EXACT []
synonym: "HGBF Test" EXACT []
xref: NCIT:C92262
is_a: SCDO:0000522 ! Hemoglobin Variant Test
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hemoglobin F Measurement\")\n\nAdd sub-classes of \"Fetal hemoglobin determination\" in SNOMED CT?" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C92262
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000067
name: Hemoglobin Genotype S/Beta Zero Thalassaemia
def: "When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a null mutation, called beta-zero, because of the resulting inability to synthesize any beta-globin chain." []
synonym: "S/Beta-Zero-Thal Genotype" EXACT []
synonym: "S/Beta-Zero-Thalassaemia Genotype" EXACT []
synonym: "S/Beta-Zero-Thalassemia" EXACT []
is_a: SCDO:1000107 ! Hemoglobin Genotype S/Beta Thalassemia
relationship: RO:0003303 NCIT:C98835 ! causes condition Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000196 SCDO:0002475 ! has contributing genetic variation Beta-Zero Thalassemia Mutation
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000241 ! causes molecular phenotype Absent Hemoglobin A
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "ref_8020"
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000068
name: deprecated Severe S/Beta-Plus-Thal
def: "'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a severe beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'" []
synonym: "Severe S/Beta-Plus-Thal" EXACT []
synonym: "Severe S/Beta-Plus-Thal Genotype" EXACT []
synonym: "Severe S/Beta-Plus-Thalassaemia Genotype" EXACT []
is_a: SCDO:1000091 ! deprecated Sickle beta plus thalassemia
property_value: SCDO:0000340 "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." xsd:string
is_obsolete: true
replaced_by: SCDO:1000078

[Term]
id: SCDO:1000069
name: Hemoglobin Genotype S/HPFH
def: "Genotype whereby a person is heterozygous for a hemoglobin S mutation and heterozygous for a mutation that causes persistant fetal hemoglobin production into adulthood. HPFH causative mutations are largely due to deletions in the beta-globin locus, but also by point mutations in the gamma-globin gene promoters." []
synonym: "Haemoglobin Genotype S/HPFH" EXACT []
synonym: "S/HPFH Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:1000010 ! causes condition Sickle Cell Disease-S/HPFH
relationship: SCDO:1000196 SCDO:0006860 ! has contributing genetic variation HBG1 and/or HBG2 Mutations
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000063 ! has contributing genetic variation HBB, 106-KB DEL
relationship: SCDO:1000222 HP:0011904 ! causes molecular phenotype Increased Hemoglobin F
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Stamatoyannopoulos, G. (2005). Control of globin gene expression during development and erythroid differentiation. Experimental Hematology, 33(3), 259. http://doi.org/10.1016/j.exphem.2004.11.007" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000070
name: Hemoglobin Genotype S/Lepore Boston
def: "A compound heterozygous genotype, involving the mutations for Hemoglobin S (beta6Glu>Val) and Hemoglobin Lepore Boston." []
synonym: "Haemoglobin Genotype S/Lepore" EXACT []
synonym: "S/Lepore" EXACT []
synonym: "S/Lepore Boston Genotype" EXACT []
synonym: "S/Lepore Genotype" EXACT []
is_a: SCDO:1000107 ! Hemoglobin Genotype S/Beta Thalassemia
relationship: RO:0003303 SCDO:0001063 ! causes condition Sickle Cell Disease-S/Lepore Boston
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000209 ! has contributing genetic variation Crossover between delta (HBD) and beta globin (HBB) gene loci
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000089 ! causes molecular phenotype Hemoglobin Lepore Boston
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "PMID: 7055103" xsd:string
property_value: SCDO:0000340 "Stevens MC, Lehmann H, Mason KP, Serjeant BE, Serjeant GR. 1982. Sickle cell Hb Lepore Boston syndrome. Uncommon differential diagnosis to homozygous sickle cell disease.  Am J Dis Child. 136(1):19-22." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000071
name: Hemoglobin Genotype A/Jamaica Plain
def: "A genotype that involves a double mutation in one beta-globin gene that results in hemoglobin with low oxygen affinity, which results in the polymerisation of the hemoglobin variant (hemoglobin Jamaica Plain) and thus sickling of erythorcytes." []
synonym: "A/Jamaica Plain Genotype" EXACT []
synonym: "A/Jamaica Plain Haemoglobin Genotype" EXACT []
synonym: "A/Jamaica Plain Hemoglobin Genotype" EXACT []
synonym: "Haemoglobin Genotype A/Jamaica Plain" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:1000164 ! causes condition Sickle Cell Disease A/Jamaica Plain
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000047 ! has contributing genetic variation HBB, LEU68PHE
relationship: SCDO:1000222 SCDO:1000072 ! causes molecular phenotype Hemoglobin Jamaica Plain
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3 xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000072
name: Hemoglobin Jamaica Plain
def: "A sickling hemoglobin with reduced oxygen affinity that causes severe hemolytic anemia and sickling of erythrocytes." []
synonym: "Hb Jamaica Plain" EXACT []
synonym: "Hb JP" EXACT []
synonym: "Hemoglobin JP" EXACT []
is_a: SCDO:1000082 ! Sickling Hemoglobin with Two Beta-Globin Gene Substitutions
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000047 ! has causal or contributing genetic variation HBB, LEU68PHE
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." xsd:string
property_value: SCDO:0000340 http://www.nejm.org/doi/full/10.1056/NEJMoa040771#t=article xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000073
name: Hemoglobin S-Antilles
def: "A form of hemoglobin caused by two mutations in its beta-chains, the classic beta S mutation (beta 6 Glu>Val) and beta 23 Val>Ile. Hemoglobin S-Antilles has the same electrophoretic mobility as Hemoglobin S but a distinct isoelectric focus and produces sickling in the carriers of the Hb A/S Antilles trait." []
is_a: SCDO:1000082 ! Sickling Hemoglobin with Two Beta-Globin Gene Substitutions
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000045 ! has causal or contributing genetic variation HBB, VAL23ILE
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." xsd:string
property_value: SCDO:0000340 "0244"
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000074
name: Hemoglobin S-Oman
def: "A form of hemoglobin caused by two mutations in a beta-globin chain, the classic beta S mutation (beta6 Glu> Val) and a beta121 Glu > Lys mutation identical to that of Hb-O Arab. The hemoglobin variant has reduced solubility and there is an apparent increase in red cell sickling tendency. It is reported to cause a rare dominant form of sickle cell disease, Sickle Cell Disease A/S-Oman." []
synonym: "Hb S-Oman" EXACT []
synonym: "Hemoglobin S (Oman)" EXACT []
is_a: SCDO:1000082 ! Sickling Hemoglobin with Two Beta-Globin Gene Substitutions
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000040 ! has causal or contributing genetic variation HBB, GLU121LYS
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." xsd:string
property_value: SCDO:0000340 "0245"
property_value: SCDO:0000340 "Nagel, R.L., Daar, S., Romero, J.R., Suzuka, S.M., Gravell, D., Bouhassira, E., Schwartz, R.S., Fabry, M.E. and Krishnamoorthy, R., 1998. HbS-Oman heterozygote: a new dominant sickle syndrome. Blood, 92(11), pp.4375-4382." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000075
name: Hemoglobin Genotype A/S-Oman
def: "Dominant heterozygosity for the double HBB Glu6Val and Glu121Lys mutation." []
synonym: "A/S-Oman Genotype" EXACT []
synonym: "A/S-Oman Haemoglobin Genotype" EXACT []
synonym: "A/S-Oman Hemoglobin Genotype" EXACT []
synonym: "Haemoglobin Genotype A/S-Oman" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:1000165 ! causes condition Sickle Cell Disease A/S-Oman
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000040 ! has contributing genetic variation HBB, GLU121LYS
relationship: SCDO:1000222 SCDO:1000074 ! causes molecular phenotype Hemoglobin S-Oman
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.sciencedirect.com/science/article/pii/S014067361061029X
property_value: SCDO:0000340 "PMID: 9834244" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000076
name: Mild Sickle Cell Disease-S Beta Minus Thalassemia
def: "A form of sickle cell thalassemia, with a mild clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." []
synonym: "Mild Sickle Cell Disease-S Beta Minus Thalassaemia" EXACT []
synonym: "Mild Sickle Cell-Beta Minus Thalassaemia" EXACT []
synonym: "Mild Sickle Cell-Beta Minus Thalassemia" EXACT []
is_a: SCDO:0001056 ! Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1000210 SCDO:0001765 ! has causal or contributing genetic variation Beta-Minus Thalassemia Mutation
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98837
property_value: SCDO:0000340 "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000077
name: Moderate Sickle Cell Disease-S Beta Minus Thalassemia
def: "A form of sickle cell thalassemia, with a moderate clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." []
synonym: "Moderate Sickle Cell Disease-S Beta Minus Thalassaemia" EXACT []
synonym: "Moderate Sickle Cell-Beta Minus Thalassaemia" EXACT []
synonym: "Moderate Sickle Cell-Beta Minus Thalassemia" EXACT []
is_a: SCDO:0001056 ! Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:1000210 SCDO:0001765 ! has causal or contributing genetic variation Beta-Minus Thalassemia Mutation
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98837
property_value: SCDO:0000340 "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000078
name: Severe Sickle Cell Disease-S Beta Minus Thalassemia
def: "A form of sickle cell thalassemia, with a severe clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells." []
synonym: "Severe Sickle Cell Disease-S Beta Minus Thalassaemia" EXACT []
synonym: "Severe Sickle Cell-Beta Minus Thalassaemia" EXACT []
synonym: "Severe Sickle Cell-Beta Minus Thalassemia" EXACT []
is_a: SCDO:0001056 ! Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:0000664 SCDO:0000147 ! treated with Blood Transfusion
relationship: SCDO:0000664 SCDO:0000506 ! treated with Hematopoietic Stem Cell Transplantation
relationship: SCDO:1000210 SCDO:0001765 ! has causal or contributing genetic variation Beta-Minus Thalassemia Mutation
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C98837
property_value: SCDO:0000340 "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000079
name: deprecated Moderate S/Beta-Plus-Thal
def: "'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a moderate beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'" []
synonym: "Moderate S/Beta-Plus-Thalassaemia" EXACT []
is_a: SCDO:1000091 ! deprecated Sickle beta plus thalassemia
property_value: SCDO:0000340 "Rees, D.C., Williams, T.N. and Gladwin, M.T., 2010. Sickle-cell disease. The Lancet, 376(9757), pp.2018-2031." xsd:string
is_obsolete: true
replaced_by: SCDO:1000077

[Term]
id: SCDO:1000080
name: deprecated Mild S/Beta-Plus-Thal
def: "'Not described [Curator team: []]'" []
synonym: "Mild S/Beta-Plus-Thalassaemia" EXACT []
is_a: SCDO:1000091 ! deprecated Sickle beta plus thalassemia
is_obsolete: true
replaced_by: SCDO:1000076

[Term]
id: SCDO:1000081
name: Hemoglobin Genotype C/S Antilles
def: "Compound heterozygosity for the hemoglobin C (HBB Glu6Lys) mutation and the double HBB Glu6Val, Val23Ile mutation of hemoglobin S-Antilles." []
synonym: "beta6Glu>Lys/beta6Glu>Val, beta23Val>Ile" EXACT []
synonym: "C/S Antilles Genotype" EXACT []
synonym: "C/S Antilles Haemoglobin Genotype" EXACT []
synonym: "C/S Antilles Hemoglobin Genotype" EXACT []
synonym: "Haemoglobin Genotype C/S Antilles" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:1000166 ! causes condition Sickle Cell Disease C/S Antilles
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000041 ! has contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000196 SCDO:1000045 ! has contributing genetic variation HBB, VAL23ILE
relationship: SCDO:1000222 SCDO:0000513 ! causes molecular phenotype Hemoglobin C
relationship: SCDO:1000222 SCDO:1000073 ! causes molecular phenotype Hemoglobin S-Antilles
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "DOI: 10.1016/S0140-6736(10)61029-X" xsd:string
property_value: SCDO:0000340 "PMID: 21131035" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000082
name: Sickling Hemoglobin with Two Beta-Globin Gene Substitutions
def: "A hemoglobin that sickles due to the presence of two beta-globin gene mutations within the same HBB gene." []
synonym: "Doubly Substituted Sickling Hemoglobin" EXACT []
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:0003807 ! Abnormal Hemoglobin
property_value: http://purl.org/dc/elements/1.1/source "0245"
property_value: http://purl.org/dc/elements/1.1/source https://www.nejm.org/doi/full/10.1056/NEJMoa040771
property_value: http://purl.org/dc/elements/1.1/source "v=onepage&q=HbA%2FJamaica%20Plain&f=false"
property_value: SCDO:0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000083
name: Hemoglobin S-South End
def: "An abnormal hemoglobin in which two mutations occurring in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the lysine in position 132 is replaced by asparagine." []
is_a: SCDO:1000082 ! Sickling Hemoglobin with Two Beta-Globin Gene Substitutions
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000087 ! has causal or contributing genetic variation HBB, LYS132ASN
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"/\"Sickling Hemoglobin with Two Beta-Globin Gene Substitutions\"." xsd:string
property_value: SCDO:0000340 "Luo, H.Y., Adewoye, A.H., Eung, S.H., Skelton, T.P., Quillen, K., McMahon, L., Steinberg, M.H. and Chui, D.H., 2004. A novel sickle hemoglobin: Hemoglobin S-South End. Journal of pediatric hematology/oncology, 26(11), pp.773-776." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000084
name: Hemoglobin Genotype S/Quebec-Chori
def: "A compound heterozygous genotype, involving the mutations for Hemoglobin S and Hemoglobin Quebec Chori, which shows an electrophoretic pattern similar to that of the Hb A/S Genotype, but shows sickling." []
synonym: "beta6Glu>Val/beta87Thr>Ile" EXACT []
synonym: "Haemoglobin Genotype S/Quebec-Chori" EXACT []
synonym: "S/Quebec-Chori Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:1000086 ! causes condition Sickle Cell Disease-S/Quebec Chori
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000046 ! has contributing genetic variation HBB, THR87ILE
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000085 ! causes molecular phenotype Hemoglobin Quebec Chori
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Pediatr Blood Cancer. 2007 Aug;49(2):207-10." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000085
name: Hemoglobin Quebec Chori
def: "An abnormal hemoglobin in which a threonine is replaced by an isoleucine residue at the eighty-seventh position of beta chains. It migrates like HbA but promotes sickling." []
synonym: "Hb Quebec-Chori" EXACT []
xref: MESH:C070823
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:0003807 ! Abnormal Hemoglobin
relationship: SCDO:1000210 SCDO:1000046 ! has causal or contributing genetic variation HBB, THR87ILE
property_value: http://purl.org/dc/elements/1.1/source http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3 xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/MESH/C070823
property_value: SCDO:0000303 "Suggest update to description in MESH (the term in MESH doesn't currently have a description).\nAlso request inclusion in the HPO, below \"Abnormal Hemoglobin\", for the sake of completion." xsd:string
property_value: SCDO:0000340 https://allaboutblood.com/2012/05/14/sickle-haemoglobin-and-varients/
property_value: SCDO:0000340 "Witkowska, H.E., Lubin, B.H., Beuzard, Y., Baruchel, S., Esseltine, D.W., Vichinsky, E.P. et al. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. N Engl J Med. 1991; 325: 1150–1154" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000086
name: Sickle Cell Disease-S/Quebec Chori
def: "A severe compound heterozygous sickling disorder characterized by the presence of both hemoglobin S and hemoglobin Quebec Chori." []
synonym: "Sickle Cell-Hemoglobin Quebec Chori Disease" EXACT []
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
relationship: SCDO:0000663 CHMO:0001009 ! diagnosed using tool High-Performance Liquid Chromatography
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000084 ! has causal genotype Hemoglobin Genotype S/Quebec-Chori
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000046 ! has causal or contributing genetic variation HBB, THR87ILE
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000085 ! has causal molecular phenotype Hemoglobin Quebec Chori
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/17551985
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000087
name: HBB, LYS132ASN
def: "A mutation where the lysine residue in position 132 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation on its own produces Hb Yamagata which has reduced oxygen affinity, but no distinctive clinical abnormalities. However, when present in the same gene as the Hb S mutation (HBB, GLU6VAL), the sickling HbS-South End is produced." []
synonym: "Contributing Beta S-South End Mutation" EXACT []
synonym: "Contributing Hb S-South End Mutation" EXACT []
synonym: "Hb Yamagata Mutation" EXACT []
synonym: "LYS132ASN" EXACT []
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:1000090 ! causes or contributes to condition Sickle Cell Disease-S/S-South End
relationship: SCDO:1000184 SCDO:1000088 ! contributes to genotype Hemoglobin Genotype S/S-South End
relationship: SCDO:1000217 SCDO:1000083 ! causes or contributes to molecular phenotype Hemoglobin S-South End
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0302"
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000088
name: Hemoglobin Genotype S/S-South End
def: "A compound heterozygous genotype, involving the mutations for hemoglobin S and hemoglobin S-South End." []
synonym: "beta Glu6Val, GAG>GTG/beta Glu6Val, GAG>GTG; beta Lys132Asn, AAA>AAC" EXACT []
synonym: "beta6Glu>Val/beta132Lys>Asn" EXACT []
synonym: "Haemoglobin Genotype S/S-South End" EXACT []
synonym: "S/S-South End Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:1000090 ! causes condition Sickle Cell Disease-S/S-South End
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000196 SCDO:1000087 ! has contributing genetic variation HBB, LYS132ASN
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000083 ! causes molecular phenotype Hemoglobin S-South End
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/15543018
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000089
name: Hemoglobin Lepore Boston
def: "The most common Hemoglobin Lepore type and the only type of the three known variants described in association with HbS. This abnormal hemoglobin consists of two normal alpha globin chains (HBA) and two deltabeta globin fusion chains which occur due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis." []
synonym: "Hb Lepore Boston-Washington" EXACT []
synonym: "Hb Lepore-B-W" EXACT []
synonym: "Hb Lepore-Boston-Washington" EXACT []
synonym: "Hb Lepore-Washington-Boston" EXACT []
synonym: "Hb Lepore-WB" EXACT []
synonym: "Hemoglobin Lepore Boston-Washington" EXACT []
synonym: "Hemoglobin Lepore-Boston-Washington" EXACT []
is_a: SCDO:0000007 ! Abnormal Hemoglobin in SCD
is_a: SCDO:0003807 ! Abnormal Hemoglobin
property_value: SCDO:0000303 "Suggest inclusion in the HPO, below \"Abnormal Hemoglobin\".\n\nHb Lepore is produced at a reduced rate and this is why the disease is related to the Β-thalassemic syndromes.\n\nQuantity in heterozygotes 7-13%; found in combination with Hb S, Hb C, beta+-thal, and in the homozygous state.\n\nThe most common Hb Lepore type; found mainly in Italian families; it has also been observed in families from Rumania, Yugoslavia, Turkey, Cyprus, Jamaica, Cuba, Greece, England, Australia, Mexico, etc" xsd:string
property_value: SCDO:0000340 http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome#Homozygous_Hb_Lepore xsd:string
property_value: SCDO:0000340 http://globin.cse.psu.edu/html/huisman/variants/hybrid/Lepore-Boston-Washington.html xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000090
name: Sickle Cell Disease-S/S-South End
def: "A rare, reported severe, type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin S-South End." []
synonym: "Sickle Cell-Hemoglobin S-South End Disease" EXACT []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000163 ! Compound Heterozygous Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000088 ! has causal genotype Hemoglobin Genotype S/S-South End
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000087 ! has causal or contributing genetic variation HBB, LYS132ASN
relationship: SCDO:1000218 EUPATH:0000215 ! has manifestation Severe Anemia
relationship: SCDO:1000223 SCDO:0000514 ! has causal molecular phenotype Hemoglobin S
relationship: SCDO:1000223 SCDO:1000083 ! has causal molecular phenotype Hemoglobin S-South End
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Luo, H.Y., Adewoye, A.H., Eung, S.H., Skelton, T.P., Quillen, K., McMahon, L., Steinberg, M.H. and Chui, D.H., 2004. A novel sickle hemoglobin: Hemoglobin S-South End. Journal of pediatric hematology/oncology, 26(11), pp.773-776." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000091
name: deprecated Sickle beta plus thalassemia
def: "'Sb+ thalassemia is an inherited condition. Hemoglobin S comes from one parent and Beta plus thalassemia comes from the other parent. Instead of appearing round (like donuts), red blood cells are somewhat small, pale and misshapen. [Curator team: []]'" []
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true
replaced_by: SCDO:0001056

[Term]
id: SCDO:1000092
name: deprecated-Acute Severe Headache
def: "A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis." []
xref: MESH:D003027
is_a: SCDO:0001336 ! from phenotype
property_value: SCDO:0000303 "Ask a clinician if this is different to a cluster headache?" xsd:string
property_value: SCDO:0000340 https://meshb.nlm.nih.gov/record/ui?ui=D003027 xsd:string
is_obsolete: true
replaced_by: SCDO:0001288

[Term]
id: SCDO:1000093
name: Adverse Event (AE)
def: "A medically undesirable event occurring in a research subject, such as an abnormal sign, symptom, worsening of a disease, injury, etc. A serious adverse event (SAE) results in death, hospitalization (or increased hospital stay), persistent disability, birth defect, or any other outcome that seriously jeopardizes the subject's health." []
synonym: "Adverse Reaction" EXACT []
xref: OAE:0000001
is_a: SCDO:0000391 ! Disease Modifier
property_value: SCDO:0000340 OAE:0000001
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000093 xsd:string

[Term]
id: SCDO:1000094
name: Research Benefit
def: "A desirable research outcome or state of affairs, such as medical treatment, clinically useful information, or self-esteem. In the oversight of human subjects research, money is usually not treated as a benefit." []
is_a: SCDO:0300005 ! Research Characteristics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "Shamoo AE and Resnik DB, Responsible Conduct of Research, 3rd ed. (New York: Oxford University Press, 2015)." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000095
name: Conflict of Interest
def: "A situation in which an individual or their close associates might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust.The concept refers both to actual conflict of interest and the appearance or perception of conflict." []
synonym: "Interest Conflict" EXACT []
xref: MESH:D016265
is_a: SCDO:0300005 ! Research Characteristics
is_a: SCDO:1000430 ! Ethics Related Concept
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016265 xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000097
name: Human Subject
def: "An homo sapiens that bears an experimental subject role which is realized through his/her participation in a scientific technique as the subject of interest (ie as the subject about which data is generated in an assay or study, or the entity that is transformed or modified in a material processing technique)." []
xref: ERO:0001964
is_a: SCDO:0300005 ! Research Characteristics
property_value: SCDO:0000340 ERO:0001964
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000097 xsd:string

[Term]
id: SCDO:1000098
name: Case Report Form (CRF)
def: "A paper or electronic questionnaire specifically used in research by the sponsor of the research to collect data from each research participant. All data on each participant in the study are held and/or documented in the CRF, including adverse events." []
is_a: SCDO:0300003 ! Publication Formats
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps as parent of \"electronic case report form\" in the Ontology for Biomedical Investigations (OBI)" xsd:string
property_value: SCDO:0000340 "Debbie Kennedy, CRF Designer, Canary Publications, ISBN 0-9531174-7-2" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000099
name: Modifier Gene
def: "Genes with alleles that affect the phenotype associated with a nonallelic gene." []
synonym: "Gene, Modifier" EXACT []
xref: MESH:D060045
is_a: SCDO:0000444 ! Genetic Disease Modifier
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D060045
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000099 xsd:string

[Term]
id: SCDO:1000100
name: ICD-10-CM Code Type
def: "The type of ICD-10-CM code, in terms of a code's usability for reimbursement purposes." []
is_a: SCDO:0000245 ! Clinical Coding
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000103
name: Genetic Locus
def: "A specific region that is mapped within a genome. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or hereditary disease." []
synonym: "Genetic Loci" EXACT []
synonym: "Loci, Genetic" EXACT []
synonym: "Locus, Genetic" EXACT []
xref: MESH:D056426
is_a: SCDO:0005722 ! Genetic Structure
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D056426
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000103 xsd:string

[Term]
id: SCDO:1000104
name: Hemoglobin Subunits
def: "The protein subunits that comprise multimeric hemoglobins." []
xref: MESH:D055554
is_a: NCIT:C26548 ! Gene Product
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055554
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000104 xsd:string

[Term]
id: SCDO:1000105
name: Alpha-Globin Family Members
def: "Members of the alpha-globin family. In humans, they are encoded in a gene cluster on chromosome 16. They include hemoglobin subunit zeta and hemoglobin subunit alpha. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult hemoglobin is comprised of 2 alpha-globin chains and 2 beta-globin chains." []
synonym: "Alpha-Globins" EXACT []
xref: MESH:D055542
is_a: SCDO:0005339 ! Globin Phenotype
is_a: SCDO:1000104 ! Hemoglobin Subunits
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055542
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000105 xsd:string

[Term]
id: SCDO:1000106
name: Sickle Cell Disease
def: "Sickle cell disease (SCD) is a pleiotropic inherited disorder of the blood, characterised by the appearance of sickle-shaped red blood cells and anemia. It results from homozygosity for the sickle beta-globin gene mutation at position 6 (glu > val), or compound heterozygosity for the sickle gene and either another mutation for a different hemoglobin variant or one of numerous beta-thalassemia\n mutations." []
synonym: "Banana Cell Disease" EXACT []
synonym: "Drepanocytosis" EXACT []
synonym: "SCD" EXACT []
synonym: "Sickle Cell Disorder" EXACT []
synonym: "Sickle Cell Hemoglobinopathy" EXACT []
synonym: "Sickle Hemoglobinopathy" EXACT []
synonym: "Sickle-Cell Disorder" EXACT []
is_a: SCDO:0000552 ! Hemoglobinopathy
relationship: SCDO:0000469 SCDO:0000311 ! has clinical code D57 Sickle-Cell Disorders
relationship: SCDO:1000210 SCDO:0009786 ! has causal or contributing genetic variation Other HBB Variants
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
property_value: http://purl.org/dc/elements/1.1/source https://en.wikipedia.org/wiki/Sickle_cell_disease
property_value: SCDO:0000303 "Suggest update to description in NCIT.\n\nSickle cell diseases include inheritance of the gene for sickle hemoglobin from one parent and one of the following:\nA gene for sickle hemoglobin from the other parent (Hb SS),\nA gene for another abnormal hemoglobin from the other parent (Hb SC, HbSD Punjab, HbSO Arab, HbS Leopore, or Hb SE),\nA gene that limits hemoglobin production from the other parent (sickle beta +/0 thalassemia). In S beta (+) thalassemia there is some production of beta globin, and in S beta (0) thalassemia there is no production of beta globin." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C34383
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/19902523
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000107
name: Hemoglobin Genotype S/Beta Thalassemia
def: "The combination of the hemoglobin S mutation (beta6Glu>Val) and a beta-thalassemia mutation." []
synonym: "Hemoglobin Genotype S/Beta Thalassaemia" EXACT []
synonym: "S/Beta -Thal Genotype" EXACT []
synonym: "S/Beta -Thalassaemia Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 NCIT:C95539 ! causes condition Sickle Beta Thalassemia
relationship: SCDO:1000196 SCDO:0007624 ! has contributing genetic variation Beta Thalassemia Genotype
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:1000240 ! causes molecular phenotype Reduced or Absent Hemoglobin A
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459467/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000108
name: HBB, SER9TYR
def: "A mutation where the serine in position 9 in the primary sequence of a beta-chain produced by the HBB gene is replaced by tyrosine. This mutation is one of 2 amino acid substitutions in the same beta chain that produces the asymptomatic Hemoglobin D-Agri, the other mutation being HBB, GLU121GLN, which on its own produces Hemoglobin D-Punjab." []
synonym: "Beta D-Agri Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:1000007 ! causes or contributes to molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0502"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000109
name: HBB, GLU121GLN
def: "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine." []
comment: Derived from a point mutation in the beta-globin gene (HBB: c.364G>C; rs33946267).
synonym: "Beta 121Glu>Gln" EXACT []
synonym: "Beta D-Punjab Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
is_a: SCDO:0009786 ! Other HBB Variants
relationship: RO:0003302 SCDO:0001061 ! causes or contributes to condition Sickle Cell Disease-S/D-Punjab
relationship: RO:0003302 SCDO:1000059 ! causes or contributes to condition Hemoglobin D-Punjab Trait
relationship: SCDO:1000184 SCDO:1000050 ! contributes to genotype Hemoglobin Genotype S/D-Punjab
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:0000528 ! causes or contributes to molecular phenotype Hemoglobin D-Punjab
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0065"
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382585/
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000110
name: HBB, GLY16ARG
def: "A mutation where the glycine in position 16 in the primary sequence of a beta-chain produced by the HBB gene is replaced by arginine." []
synonym: "Beta D-Bushman Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:1000007 ! causes or contributes to molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0060"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000111
name: HBB, ASN19LYS
def: "A mutation where the asparargine acid in position 19 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine." []
synonym: "Beta D-Ouled Rabah Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:1000007 ! causes or contributes to molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0064"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000112
name: HBB, GLU22GLN
def: "A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine." []
synonym: "Beta D-Iran Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:1000007 ! causes or contributes to molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0063"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000113
name: HBB, GLU22VAL
def: "A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine." []
synonym: "Beta D-Granada Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:1000007 ! causes or contributes to molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0061"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000114
name: HBB, THR87LYS
def: "A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine." []
synonym: "Beta D-Ibadan Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:1000007 ! causes or contributes to molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0062"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000115
name: HBB, GLU121ALA
def: "A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by alanine." []
synonym: "Beta D-Neath Mutation" EXACT []
is_a: SCDO:0002305 ! Hemoglobin D Disease Causal Mutation
relationship: SCDO:1000184 SCDO:1000054 ! contributes to genotype Hemoglobin Genotype SD
relationship: SCDO:1000184 SCDO:1000226 ! contributes to genotype Hemoglobin Genotype AD
relationship: SCDO:1000184 SCDO:1000230 ! contributes to genotype Hemoglobin Genotype DD
relationship: SCDO:1000217 SCDO:1000007 ! causes or contributes to molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "0445"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000116
name: Adja
def: "The Adja ethnic group are mostly farmers and live in the southern part of Benin Republic. They make up 15% of the general country population. This group of people migrated into Benin between the 12th and 13th centuries from River Mono. The primary language is Aja-Gbe with a majority of the people being trilingual." []
synonym: "Adja Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2011-2012)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.worldatlas.com/articles/major-ethnic-groups-of-benin.html
property_value: SCDO:1000288 "Negigable" xsd:string

[Term]
id: SCDO:1000117
name: Bariba
def: "Bariba is the ethnic group dominating the northern side of Benin, who constitute 9% of the population. They are the first inhabitants of Benin and are concentrated in the capital city, Nikki. One of their leading practices is horse riding, which is a practice that has been enjoyed from generation to generation. With agriculture being their dominant occupation, Bariba people have a diverse range of produce such as corn, rice and palm oil." []
synonym: "Bariba Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2011-2012)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.worldatlas.com/articles/major-ethnic-groups-of-benin.html
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000118
name: Dendi
synonym: "Dendi Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000119
name: Fon
def: "The largest ethnic group in Benin is Fon/Dahomey which constitutes 39% of the total population. Established in 1600 by the Fon, a group that came about through the intermarriage between the Adja and local Gedevi." []
synonym: "Fon Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2011-2012)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.worldatlas.com/articles/major-ethnic-groups-of-benin.html
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000120
name: Yoa
synonym: "Yoa Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000121
name: Betamaribe
synonym: "Betamaribe Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000122
name: Embu
def: "The Embu are a Bantu-speaking people who are closely related to the Gikuyu of Ndia and Gicugu to the west, the Mbeere and the Kamba to the southeast, and the Chuka and the Meru to the north in Kenya." []
synonym: "Embu Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.encyclopedia.com/humanities/encyclopedias-almanacs-transcripts-and-maps/embu-0
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000123
name: Kalenjin
def: "The Kalenjin ethnic group are one of the five largest ethnic groups in Kenya. They are a Nilotic ethnic group and they are mainly farmers." []
synonym: "Kalenjin Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.africa.upenn.edu/NEH/kethnic.htm
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000124
name: Kamba
def: "The Kamba ethnic group, also known as Akamba is one of the five largest ethnic groups in Kenya. They are Bantu-speaking people and primarily agriculturists." []
synonym: "Kamba Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.africa.upenn.edu/NEH/kethnic.htm
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000125
name: Kikuyu
def: "The Kikuyu are the largest single ethnic tribe in Kenya, making up 22% of the country's population. It is believed that the Kikuyu people migrated from Lake Chad to East Africa in 1000 AD, settling in the fertile central highlands of Kenya and engaging in farming." []
synonym: "Kikuyu Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.worldatlas.com/articles/who-are-the-kikuyu.html
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000126
name: Kisii
def: "The Kisii tribe (also known as the Gusii tribe) is a Bantu ethnic group who occupy the Kisii highlands in Nyanza, Western Kenya. The Kisiis constitute the sixth largest ethnic group, comprising about seven percent of the national population. Kisii, which is their ethnic language, is also traditionally known as Ekegusii." []
synonym: "Gusii" EXACT []
synonym: "Kisii Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/kisii-tribe.html
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000127
name: Luhya
def: "The Luhya ethnic group, also known as the Abaluhya, Baluhya, or Abaluyia, is a Bantu tribe living in Kenya's agriculturally fertile western region. They are the second largest tribe in Kenya and neighbors to some of the Nilotic tribes, including the Luo, Kalenjin, Maasai and Teso (Iteso)." []
synonym: "Luhya Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/luhya-tribe.html
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000128
name: Luo
def: "Luo, also called Joluo or Kavirondo constitute the fourth largest ethnic group in Kenya. The Luo speak a Nilotic language of the Nilo-Saharan language family." []
synonym: "Luo Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.britannica.com/topic/Luo-people
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000129
name: Maasai
def: "A smaller ethnic group, accounting for only about 0.7 percent of Kenya's population, with a similar number living in Tanzania. Maasais speak Maa, a Nilotic ethnic language from their origin in the Nile region of North Africa." []
synonym: "Maasai Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/maasai-tribe.html
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000130
name: Peulh
synonym: "Peulh Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000131
name: Yoruba
def: "Yoruba is an ethnic group coming from Nigeria and well settled along the eastern boundary of Benin. They are more than 18% of the population. The majority of the Yoruba people in Benin are descendants of the Ife tribe, and the Yoruba people are predominantly of the Muslim religion." []
synonym: "Yoruba Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2011-2012)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.worldatlas.com/articles/major-ethnic-groups-of-benin.html
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000132
name: Meru
def: "The Meru tribe or Merus is a Bantu ethnic group. They reside on Mount Kenya's agriculturally rich northeastern slopes, in Kenya's Eastern Province. The name Meru refers to both the people and the location. Merus are primarily agrarian, raising a few domestic animals." []
synonym: "Meru Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/meru-tribe.html
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000133
name: Mijikenda/Swahili
def: "The Mijikenda tribe is a Kenyan coastal Bantu tribe that consists of nine closely related sub-tribes. \"Mijikenda\" literally means nine homes or nine homesteads (in Swahili), referring to the common ancestry of the Mijikenda people. The nine Mijikenda sub-tribes are believed to be nine different homes of the same tribe. Each sub-tribe speaks its own dialect of the Mijikenda language." []
synonym: "Mijikenda" EXACT []
synonym: "Mijikenda Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/mijikenda-tribe.html
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000134
name: Somali
def: "A Cushitic speaking people comprising a small minority of Kenya's population. The Somali tend large herds of cattle, goats, sheep, and camels in the dry, arid lands of Northern Kenya. They are politically well organized and are united by both family allegiances and political treaties. The Somali also produce exquisitely carved headrests and woven artifacts." []
synonym: "Somali Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.africa.upenn.edu/NEH/kethnic.htm
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000135
name: Taita/Taveta
def: "The Taita people are a Bantu tribe living in the Taita Hills on Kenya's southwest, near the Tanzania border and surrounding plains. Taita tribe actually consists of three separate but closely-related tribes: Wadawida (or Taita), Wasaghala (Sagalla) and Wataveta (Taveta)." []
synonym: "Taita/Taveta Ethnic Group" EXACT []
synonym: "Taveta Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic Health and Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Perhaps change label to \"Taveta\"?\nInclude the Wadawida (or Taita), Wasaghala (Sagalla) and Wataveta (Taveta) as sub-classes?\nRequest inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/taita-tribe.html
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000136
name: Borana
def: "The  Borana  are  a  branch  of  the  populous  Oromo  people  found  in  southern  Ethiopia and  northern  Kenya." []
synonym: "Borana Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.tandfonline.com/doi/pdf/10.1080/17531050701452598
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000137
name: Maragoli
def: "It is the second largest sub-tribe of the Luhya ethnic group in Kenya." []
synonym: "Maragoli Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/luhya-tribe.html
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000138
name: Pokot
def: "The Pokot are a Kalenjin-speaking people whose language incorporates words from the neighboring Karamojong and Turkana. The Pokot live in an ecologically complex region that extends from the plains of eastern Uganda across the highlands of northwestern Kenya to the plains of Lake Baringo." []
synonym: "Pokot Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic Health and Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 https://www.encyclopedia.com/humanities/encyclopedias-almanacs-transcripts-and-maps/pokot
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000139
name: Turkana
def: "The Turkana tribe is a nomadic pastoralist people that inhabit the Turkana district in Kenya's Rift Valley Province. Turkana tribe is part of the Nilotic tribes and constitutes the second largest pastoralist community in Kenya after the Maasais. They speak the Turkana language, which is Nilotic and similar to the Maasai language." []
synonym: "Turkana Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2015)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://www.kenya-information-guide.com/turkana-tribe.html
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000141
name: Bassa
def: "Bassa is a Niger-Congo Kru language. Historians have traced the Bassa's origins back to Egypt nearly six thousand years ago. Due to their migration from Egypt to other parts of Africa, the Bassa in Liberia share a similar history with Bassa groups in other parts  of   the continent such as Nigeria (Bassa  Nge), The Democratic Republic of  the Congo (Bassaa la Mpasu), Togo (Basa'r), Senegal (Bassa-Ri), and Cameroon (Basaa Mpoo)." []
synonym: "Bassa Ethnic Group" EXACT []
is_a: NCIT:C16564 ! Ethnic Group
property_value: http://purl.org/dc/elements/1.1/source "Demographic and Health Surveys Program (2013)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, possibly below \"Ethnic Group\" in NCIT?" xsd:string
property_value: SCDO:0000340 http://nalrc.indiana.edu/brochures/new-broch/Bassa.pdf
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000142
name: Spectrophotometry
def: "Spectrophotometry involves the use of a spectrophotometer to measure the amount of light that a sample absorbs. The instrument operates by passing a beam of light through a sample and measuring the intensity of light reaching a detector." []
synonym: "Spectrophotometry Method" EXACT []
xref: BAO:0000049
is_a: SCDO:0000896 ! Physical Detection Method
property_value: SCDO:0000340 ?p=classes&conceptid=http%3A%2F%2Fwww.bioassayontology.org%2Fbao%23BAO:0000049
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000142 xsd:string

[Term]
id: SCDO:1000143
name: Disease Management Guideline
def: "A recommendation on the appropriate treatment and care of people with a specific disease or condition, based on the best available evidence, designed to help healthcare professionals in their work." []
synonym: "Clinical Guideline" EXACT []
xref: FaBiO:d4e2515
is_a: SCDO:1000160 ! Guideline
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000340 "d4e2515"
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000143 xsd:string

[Term]
id: SCDO:1000144
name: Recommendations for the Management of Sickle Cell Disease in South Africa
def: "Management protocols for the purposes of consistency and standardisation, which could also facilitate sharing of resources between centers for maximal utility. These recommendations have been developed for the South African setting, and it is intended to update them regularly to meet new demands and challenges." []
comment: South African Management Guidelines
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "N A Alli, M Patel, H D Alli, et al. Recommendations for the management of sickle cell disease in South Africa. SAMJ. 2014, Vol. 104, No. 11." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000145
name: National Guideline for the Control and Management of Sickle Cell Disease
def: "Guidelines for the management of specific clinical problems and protocols for various therapeutic procedures for patients with sickle cell disease and thalassaemia; to facilitate uniformity and standardization of care across different disciplines." []
comment: A Nigerian document.
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "National guideline for the control and management of sickle cell disease. 2014." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000146
name: Management of Sickle Cell Disease - The United Republic of Tanzania
def: "Guidelines for health care professionals for management of sickle cell disease in patients in the Tanzanian context." []
comment: Tanzania Management Guidelines
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Management of Sickle Cell Disease - The United Republic of Tanzania" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000147
name: A Parental Guide to Managing Sickle Cell Disease
def: "A booklet with information and standard guidelines to help parents learn about sickle cell disease and how to take care of their children with sickle cell disease." []
comment: A UK document.(for parents)
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "A parent's guide to managing sickle cell disease. Brent Sickle Cell and Thalassaemia Centre. 3rd Edition 2012." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000148
name: Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
def: "A document that includes standards and guidelines for clinical care and recommendations for how care for adults with sickle cell disease should be delivered." []
comment: A UK document (for adults with SCD)
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Standards for Clinical Care of Adults with Sickle Cell Disease in the UK, 2nd Edition.  2018, Sickle Cell Society." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000149
name: Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
def: "The second edition of the Clinical Care Guidelines of the Sickle Cell Unit, containing revised and expanded guidelines for the management of sickle cell disease. It outlines a standard of care that is informed by best practice, taking into account resource limitations locally and regionally. It also contains patient information leaflets." []
comment: Jamaican Management Guidelines
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit, 2015" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000150
name: Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
def: "Standard of care guidelines that promote excellence in sickle cell care, and that lead to improved patient experiences around care and treatment." []
comment: A Canadian document.
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Segbefia C, Pendergrast J, Amid A, et al. 2015. Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada.  The Canadian Haemoglobinopathy Association." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000151
name: Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
def: "A document that include standards and guidelines for clinical care and recommendations for how care for children with sickle cell disease should be delivered." []
comment: A UK document (for children with SCD)
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Sickle cell disease in children, standards and guidelines for clinic care. 2nd edition. October 2010" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000152
name: Evidence-Based Management of Sickle Cell Disease
def: "Guidelines providing the best science-based recommendations to guide practice decisions for primary care providers and other clinicians, nurses, and staff who provide emergency or continuity care to individuals with sickle cell disease (SCD). They assist health care professionals in the management of common issues, including routine health maintenance, the recognition and treatment of common acute and chronic complications and comorbidities of SCD, as well as the indications for and monitoring of hydroxyurea and blood transfusion therapy. The guidelines address the care of infants, children, adolescents, and adults with SCD, with the goal of facilitating high-quality and appropriate care for all individuals with this disease." []
comment: USA Management Guidelines Children
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Evidence-Based Management of Sickle Cell Disease: Expert Panel Report, 2014" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000153
name: Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives
def: "A review of service delivery across Europe to children with sickle cell disease (SCD), reporting on the available minimum standards of care and future perspectives." []
comment: European document (Colombatti)
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: http://purl.org/dc/elements/1.1/source "Colombatti R and Sainati L. Management of children with sickle cell disease in Europe: current situation and future perspectives. EMJ Hematol. 2016;4[1]:129-135." xsd:string
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000154
name: ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
def: "A document that describes various ways in which sickle cell disease can be managed and its complications can be prevented in children." []
comment: European document for children with SCD (Montalambert)
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: http://purl.org/dc/elements/1.1/source "Am J Hematol. 2011 Jan;86(1):72-5. doi: 10.1002/ajh.21865." xsd:string
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000155
name: Family Study
def: "Research conducted on members of families, examining the affects of genetics, the environment, or twin offspring." []
synonym: "Familial Studies" EXACT []
synonym: "Familial Study" EXACT []
synonym: "Family Based Study" EXACT []
synonym: "Family Study" EXACT []
xref: EDDA:familial_study
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 https://bioportal.bioontology.org/ontologies/EDDA/?p=classes&conceptid=http%3A%2F%2Fontologies.dbmi.pitt.edu%2Fedda%2FStudyDesigns.owl%23familial_study&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000155 xsd:string

[Term]
id: SCDO:1000157
name: Quality of Life Related Personal Attribute
def: "The distinguishing qualities or prominent aspects of an individual person that have some relation with quality of life." []
is_a: NCIT:C17047 ! Quality of Life
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably too specific to SCDO to be included in other ontologies?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000158
name: Crystallised Hemoglobin
def: "Hemoglobin that has undergone conformational changes resulting in increased hydrophobicity that results in the formation of solid crystals consisting of hemoglobin particles." []
synonym: "Crystallised Haemoglobin" EXACT []
synonym: "Crystallized Haemoglobin" EXACT []
synonym: "Crystallized Hemoglobin" EXACT []
synonym: "Haemoglobin Crystals" EXACT []
synonym: "Hemoglobin Crystals" EXACT []
is_a: SCDO:0003807 ! Abnormal Hemoglobin
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the HPO, below \"Abnormal Hemoglobin\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000159
name: Hemoglobin Genotype S/Beta Minus Thalassaemia
def: "When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a mutation that reduces the amount of beta-globin chain synthesised." []
is_a: SCDO:1000107 ! Hemoglobin Genotype S/Beta Thalassemia
relationship: RO:0003303 SCDO:0001056 ! causes condition Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1000196 SCDO:0001765 ! has contributing genetic variation Beta-Minus Thalassemia Mutation
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
relationship: SCDO:1000222 SCDO:0000976 ! causes molecular phenotype Reduced Hemoglobin A
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000160
name: Guideline
def: "Work consisting of a set of statements, directions, or principles presenting current or future rules or policy. Guidelines may be developed by government agencies at any level, institutions, organizations such as professional societies or governing boards, or by the convening of expert panels. The text may be cursive or in outline form, but it is generally a comprehensive guide to problems and approaches in any discipline or activity. This concept relates to the general conduct and administration of health care activities rather than to specific decisions for a particular clinical condition." []
xref: MESH:D016431
is_a: SCDO:0001000 ! SCDO
property_value: SCDO:0000303 "Do we rather want to use the more specific MESH term \"Practice Guideline\"?" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016431
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000160 xsd:string

[Term]
id: SCDO:1000161
name: Hemoglobin Genotype AS
def: "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains of hemoglobin S. Individuals with this genotype are known to be carriers of the sickle cell trait." []
synonym: "Haemoglobin Genotype AS" EXACT []
synonym: "Sickle Cell Trait Genotype" EXACT []
is_a: SCDO:1000048 ! SCD Genotype
relationship: RO:0003303 SCDO:0001055 ! causes condition Sickle Cell Trait
relationship: SCDO:1000196 SCDO:1000039 ! has contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000222 SCDO:0000514 ! causes molecular phenotype Hemoglobin S
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000162
name: deprecated-Symptomatic Sickle Cell Trait
def: "The condition in which an individual with sickle cell trait shows symptoms of sickle cell disease such as anemia or acute chest syndrome." []
comment: Often these individuals have co-inherited another hemoglobin mutation that decreases hemoglobin solubility (eg, HbS-Antilles; Hb-Quebec-Chori; HbS-Oman; Hb Jamaica Plain).\n\nOther rare causes of symptomatic sickle cell trait include: mosaicism for cells in which only the sickle mutation was expressed due to post-zygotic uniparental disomy, and when sickle cell trait coexists with pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling.
synonym: "Clinical Sickle Cell Disease in the Heterozygous State" EXACT []
synonym: "Dominant Sickle Cell Disease" EXACT []
is_a: SCDO:0000359 ! deprecated terms
property_value: http://purl.org/dc/elements/1.1/source "H7649235"
property_value: SCDO:0000340 "H7649235"
is_obsolete: true
replaced_by: SCDO:1000211

[Term]
id: SCDO:1000163
name: Compound Heterozygous Sickle Cell Disease
def: "A hemoglobinopathy in which the sickle mutation (HBB, Glu6Val) is inherited in combination with another beta-globin gene mutation, other thanHBB, Glu6Val." []
synonym: "Compound Heterozygous Sickling Disorder" EXACT []
is_a: SCDO:0001051 ! Variant Sickle Cell Syndrome
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000164
name: Sickle Cell Disease A/Jamaica Plain
def: "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta68 Leu > Phe mutation.The other beta globin allele produces normal beta globin chains." []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000211 ! Dominant Sickle Cell Disease
relationship: SCDO:0001364 HP:0000006 ! has mode of inheritance Autosomal Dominant
relationship: SCDO:1000172 SCDO:1000071 ! has causal genotype Hemoglobin Genotype A/Jamaica Plain
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000047 ! has causal or contributing genetic variation HBB, LEU68PHE
relationship: SCDO:1000218 HP:0001878 ! has manifestation Hemolytic Anemia
relationship: SCDO:1000218 NCIT:C3890 ! has manifestation Hypoxia
relationship: SCDO:1000223 SCDO:1000072 ! has causal molecular phenotype Hemoglobin Jamaica Plain
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source "t=article"
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000165
name: Sickle Cell Disease A/S-Oman
def: "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation (beta6 Glu > Val) and the hemoglobin O-Arab mutation (beta121 Glu > Lys). The other beta globin allele produces normal beta globin chains." []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000211 ! Dominant Sickle Cell Disease
relationship: SCDO:0001364 HP:0000006 ! has mode of inheritance Autosomal Dominant
relationship: SCDO:1000172 SCDO:1000075 ! has causal genotype Hemoglobin Genotype A/S-Oman
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000040 ! has causal or contributing genetic variation HBB, GLU121LYS
relationship: SCDO:1000223 SCDO:1000074 ! has causal molecular phenotype Hemoglobin S-Oman
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0245"
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000166
name: Sickle Cell Disease C/S Antilles
def: "Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta 23 Val>Ile mutation. The other beta globin allele produces normal beta globin chains." []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
is_a: SCDO:1000211 ! Dominant Sickle Cell Disease
relationship: SCDO:0000663 NCIT:C15709 ! diagnosed using tool Genetic Testing
relationship: SCDO:0000663 SCDO:0000547 ! diagnosed using tool Hemoglobin Profile Assay
relationship: SCDO:0000663 SCDO:0000666 ! diagnosed using tool Isoelectric Focusing
relationship: SCDO:0001364 SCDO:1000243 ! has mode of inheritance Autosomal Recessive Compound Heterozygous
relationship: SCDO:1000172 SCDO:1000081 ! has causal genotype Hemoglobin Genotype C/S Antilles
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000041 ! has causal or contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000210 SCDO:1000045 ! has causal or contributing genetic variation HBB, VAL23ILE
relationship: SCDO:1000223 SCDO:0000513 ! has causal molecular phenotype Hemoglobin C
relationship: SCDO:1000223 SCDO:1000073 ! has causal molecular phenotype Hemoglobin S-Antilles
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "0244"
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000170
name: Diagnosis Guideline
def: "A directive information entity that specifies how to establish a diagnosis based on clinical findings." []
xref: AERO:0000001
is_a: SCDO:1000160 ! Guideline
property_value: SCDO:0000340 AERO:0000001
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000170 xsd:string

[Term]
id: SCDO:1000173
name: Billable ICD-10-CM Code
def: "An ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes as there are no codes with a greater level of specificity under each code." []
synonym: "Specific ICD-10-CM Code" EXACT []
is_a: SCDO:1000100 ! ICD-10-CM Code Type
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/Rules/Billable_Specific_Codes
property_value: http://purl.org/dc/elements/1.1/source https://www.unboundmedicine.com/icd/view/ICD-10-CM/860000/all/About_ICD_10_CM_Coding_Guide
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000174
name: Non-Billable ICD-10-CM Code
def: "An ICD-10-CM diagnosis code that is not billable as there are more specific codes below it that contain a greater level of detail." []
synonym: "Non-specific ICD-10-CM Code" EXACT []
is_a: SCDO:1000100 ! ICD-10-CM Code Type
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.unboundmedicine.com/icd/view/ICD-10-CM/860000/all/About_ICD_10_CM_Coding_Guide
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000177
name: N48.32 Priapism due to disease classified elsewhere
def: "-" []
synonym: "N48.32" EXACT []
synonym: "Priapism due to disease classified elsewhere" EXACT []
xref: ICD10CM:N48.32
is_a: SCDO:0000607 ! ICD-10-CM Diagnosis Codes
relationship: SCDO:1000785 SCDO:0000923 ! code requires phenotype Priapism
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/N00-N99/N40-N53/N48-/N48.32
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000178
name: SickleInAfrica Extended Demographics Data Element
def: "A data element in the SickleInAfrica Extended Demographics data capture instrument." []
synonym: "SickleInAfrica Extended Demographics DE" EXACT []
is_a: SCDO:1000508 ! SickleInAfrica Data Element
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000179
name: Absent Hemoglobin E
def: "A lack of production of hemoglobin E." []
synonym: "Absent Haemoglobin E" EXACT []
synonym: "Haemoglobin E Absent" EXACT []
synonym: "Hemoglobin E Absent" EXACT []
synonym: "Normal Haemoglobin E Level" EXACT []
synonym: "Normal Hemoglobin E Level" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000181
name: Hemoglobin E Present
def: "When the abnormal hemoglobin, hemoglobin E (HbE), has been detected in a blood sample." []
synonym: "Haemoglobin E in Blood" EXACT []
synonym: "Haemoglobin E Present" EXACT []
synonym: "HbE in Blood" EXACT []
synonym: "HbE Present" EXACT []
synonym: "Hemoglobin E in Blood" EXACT []
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000187
name: Normal Hemoglobin A2 Level
def: "When the level of hemoglobin A2 detected in a sample of blood falls in the normal range for HbA2." []
synonym: "Normal Haemoglobin A2 Level" EXACT []
synonym: "Normal HbA2 Level" EXACT []
synonym: "Normal Hemoglobin A2 Concentration" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000197
name: HIV Combination Test
def: "A test to detect both HIV antibodies and HIV antigens (a part of the virus) in blood." []
comment: It can take 2 to 6 weeks for a person’s body to make enough antigens and antibodies for a combination test to detect HIV infection.
synonym: "Antibody/Antigen Tests" EXACT []
is_a: SCDO:0000571 ! HIV Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Khuthala Mnika)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology." xsd:string
property_value: SCDO:0000340 https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/19/47/hiv-testing
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000198
name: HIV Nucleic Acid Test
def: "A test to detect HIV in a person's blood." []
comment: NATS can detect HIV infection about 7 to 28 days after a person has been infected with HIV.\nNATs are very expensive and not routinely used for HIV screening unless the person had a high-risk exposure or a possible exposure with early symptoms of HIV infection.
synonym: "NAT" EXACT [] {synonymtypedef="abbreviation"}
is_a: SCDO:0000571 ! HIV Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Khuthala Mnika)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology. The more specific term \"HIV-1 nucleic acid testing\" is found in the OBI." xsd:string
property_value: SCDO:0000340 https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/19/47/hiv-testing
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000201
name: High Level Albuminuria
def: "An abnormal albumin excretion rate of more than 300 mg/g urine creatinine." []
synonym: "Macro-albuminuria" EXACT []
synonym: "Macroalbuminuria" EXACT []
is_a: SCDO:0000037 ! Albuminuria
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/141501
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000205
name: Hemoglobin C-Harlem Disease
def: "A clinically severe form of sickle cell disease resulting when a person is homozygous for Hemoglobin C-Harlem." []
is_a: SCDO:0008262 ! Structural Hemoglobinopathy
relationship: SCDO:0001364 HP:0000007 ! has mode of inheritance Autosomal Recessive
relationship: SCDO:1000210 SCDO:1000039 ! has causal or contributing genetic variation HBB, GLU6VAL
relationship: SCDO:1000210 SCDO:1000044 ! has causal or contributing genetic variation HBB, ASP73ASN
relationship: SCDO:1000223 SCDO:1000058 ! has causal molecular phenotype Hemoglobin C-Harlem
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://clinchem.aaccjnls.org/content/55/6/1228
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000206
name: Genetic Recombination
def: "Production of new arrangements of DNA by various mechanisms such as assortment and segregation, crossing over; gene conversion; genetic transformation; genetic conjugation; genetic transduction; or mixed infection of viruses." []
synonym: "Recombination" EXACT []
synonym: "Recombination, Genetic" EXACT []
xref: MESH:D011995
is_a: SCDO:0001369 ! Genetic Variation
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D011995
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000206 xsd:string

[Term]
id: SCDO:1000207
name: Homologous Recombination
def: "An exchange of DNA between matching or similar sequences." []
synonym: "Homologous Recombinations" EXACT []
xref: MESH:D059765
is_a: SCDO:1000206 ! Genetic Recombination
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D059765
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000207 xsd:string

[Term]
id: SCDO:1000208
name: Genetic Crossing Over
def: "The reciprocal exchange of segments at corresponding positions along pairs of homologous chromosomes by symmetrical breakage and crosswise rejoining forming cross-over sites (Holliday junctions) that are resolved during chromosome segregation. Crossing-over typically occurs during meiosis but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes." []
synonym: "Crossing Over, Genetic" EXACT []
xref: MESH:D003434
is_a: SCDO:1000207 ! Homologous Recombination
property_value: SCDO:0000303 "link this term to" xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D003434
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000208 xsd:string

[Term]
id: SCDO:1000209
name: Crossover between delta (HBD) and beta globin (HBB) gene loci
def: "The homologous recombination event that occurs during meiosis and results in the delta beta globin fusion chains that replace hemoglobin subunit beta chains in the abnormal hemoglobin, Hemoglobin Lepore." []
is_a: SCDO:1000208 ! Genetic Crossing Over
relationship: RO:0003302 SCDO:0000343 ! causes or contributes to condition Delta Beta Thalassemia
relationship: RO:0003302 SCDO:0000536 ! causes or contributes to condition Hemoglobin Lepore Boston Disease
relationship: RO:0003302 SCDO:0001063 ! causes or contributes to condition Sickle Cell Disease-S/Lepore Boston
relationship: RO:0003303 NCIT:C141366 ! causes condition Hemoglobin Lepore Syndrome
relationship: SCDO:1000184 SCDO:1000070 ! contributes to genotype Hemoglobin Genotype S/Lepore Boston
relationship: SCDO:1000184 SCDO:1000236 ! contributes to genotype Hemoglobin Lepore Boston Genotype
relationship: SCDO:1000217 SCDO:1000089 ! causes or contributes to molecular phenotype Hemoglobin Lepore Boston
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000211
name: Dominant Sickle Cell Disease
def: "Clinical sickle cell disease in the heterozygous state due to an additional mutation on the same allele as the beta S mutation." []
comment: Often these individuals have co-inherited another hemoglobin mutation that decreases hemoglobin solubility (eg, HbS-Antilles; Hb-Quebec-Chori; HbS-Oman; Hb Jamaica Plain).\n\nOther rare causes of symptomatic sickle cell trait include: mosaicism for cells in which only the sickle mutation was expressed due to post-zygotic uniparental disomy, and when sickle cell trait coexists with pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling.
synonym: "Dominant Sickle Cell Syndrome" EXACT []
synonym: "Dominant Sickle Syndrome" EXACT []
is_a: NCIT:C95534 ! Hemoglobin Trait
is_a: SCDO:0001051 ! Variant Sickle Cell Syndrome
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://wwwuptodatecom.uptodate.sdsl.yuntsg.cn:2222/contents/overview-of-variant-sickle-cell-syndromes
property_value: SCDO:0000303 "Hemoglobin Jamaica Plain is an example of an abnormal hemoglobin structure caused by a double mutation in 1 Hb allele." xsd:string
property_value: SCDO:0000340 http://wwwuptodatecom.uptodate.sdsl.yuntsg.cn:2222/contents/overview-of-variant-sickle-cell-syndromes
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000212
name: deprecated Disease Caused by A/Jamaica Plain Genotype
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true
replaced_by: SCDO:1000164

[Term]
id: SCDO:1000213
name: deprecated Disease Caused by A/S-Oman Genotype
is_a: SCDO:0000359 ! deprecated terms
property_value: http://purl.org/dc/elements/1.1/source "0245"
is_obsolete: true
replaced_by: SCDO:1000165

[Term]
id: SCDO:1000214
name: deprecated Disease Caused by C/S Antilles Genotype
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true
replaced_by: SCDO:1000166

[Term]
id: SCDO:1000215
name: Structural and Quantitative Hemoglobinopathy
def: "A hemoglobinopathy involving the presence of structurally abnormal hemoglobins and defects in the quantity of hemoglobins synthesised." []
is_a: SCDO:0000552 ! Hemoglobinopathy
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably too specific to the SCDO to be included in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000221
name: Alpha Thalassemia Silent Genotype
def: "A genotype whereby one of the four alpha-globin genes is faulty, either as a result of a single nucleotide variant (SNP) or of a deletion." []
synonym: "-/alpha alpha/alpha" EXACT []
is_a: EUPATH:0000034 ! Alpha Thalassemia Genotype
relationship: RO:0003303 NCIT:C95536 ! causes condition Alpha Thalassemia Silent Carrier
relationship: SCDO:1000196 SCDO:1000239 ! has contributing genetic variation Heterozygous Deletion of HBA1 or HBA2
relationship: SCDO:1000222 HP:0011907 ! causes molecular phenotype Reduced Alpha/Beta Synthesis Ratio
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 Alpha:Thalassemia
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000224
name: Easy Bruisability
def: "Increased susceptibility to bruising." []
synonym: "Bruisability, Bruising susceptibility, Easy bruising" EXACT []
synonym: "Bruise Easily" EXACT []
synonym: "Bruising Susceptibility" EXACT []
synonym: "Easy Bruising" EXACT []
is_a: HP:0002597 ! Abnormality of the Vasculature
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Suggest update to label of HPO's \"Bruising Susceptibility\". \n\"Bruising Susceptibility\" and \"Easy Bruisability\" are not actually the same thing." xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000225
name: Hemoglobin Genotype AC
def: "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin C. Individuals with this genotype are known to be carriers of the hemoglobin C trait." []
synonym: "AC Genotype" EXACT []
synonym: "AC Hemoglobin Genotype" EXACT []
synonym: "beta / beta6Glu>Lys" EXACT []
synonym: "Haemoglobin Genotype AC" EXACT []
synonym: "Hemoglobin C Trait Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000520 ! causes condition Hemoglobin C Trait
relationship: SCDO:1000196 SCDO:1000041 ! has contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000222 SCDO:0000513 ! causes molecular phenotype Hemoglobin C
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000226
name: Hemoglobin Genotype AD
def: "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin D. Individuals with this genotype are known to be carriers of the hemoglobin D trait." []
synonym: "AD Genotype" EXACT []
synonym: "AD Hemoglobin Genotype" EXACT []
synonym: "Haemoglobin Genotype AD" EXACT []
synonym: "Hemoglobin D Trait Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000525 ! causes condition Hemoglobin D Trait
relationship: SCDO:1000196 SCDO:1000108 ! has contributing genetic variation HBB, SER9TYR
relationship: SCDO:1000196 SCDO:1000109 ! has contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000196 SCDO:1000110 ! has contributing genetic variation HBB, GLY16ARG
relationship: SCDO:1000196 SCDO:1000111 ! has contributing genetic variation HBB, ASN19LYS
relationship: SCDO:1000196 SCDO:1000112 ! has contributing genetic variation HBB, GLU22GLN
relationship: SCDO:1000196 SCDO:1000113 ! has contributing genetic variation HBB, GLU22VAL
relationship: SCDO:1000196 SCDO:1000114 ! has contributing genetic variation HBB, THR87LYS
relationship: SCDO:1000196 SCDO:1000115 ! has contributing genetic variation HBB, GLU121ALA
relationship: SCDO:1000222 SCDO:1000007 ! causes molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000227
name: Hemoglobin Genotype AE
def: "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin E. Individuals with this genotype are known to be carriers of the hemoglobin E trait." []
synonym: "AE Genotype" EXACT []
synonym: "AE Hemoglobin Genotype" EXACT []
synonym: "beta / beta26Glu>Lys" EXACT []
synonym: "Haemoglobin Genotype AE" EXACT []
synonym: "Hemoglobin E Trait Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000531 ! causes condition Hemoglobin E Trait
relationship: SCDO:1000196 SCDO:1000042 ! has contributing genetic variation HBB, GLU26LYS
relationship: SCDO:1000222 SCDO:1000009 ! causes molecular phenotype Hemoglobin E
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Clair Ingram)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000228
name: Hemoglobin Genotype AO-Arab
def: "A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin O-Arab. Individuals with this genotype are known to be carriers of the hemoglobin O-Arab trait." []
synonym: "AO-Arab Genotype" EXACT []
synonym: "AO-Arab Hemoglobin Genotype" EXACT []
synonym: "beta / beta121Glu>Lys" EXACT []
synonym: "Haemoglobin Genotype AO-Arab" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000545 ! causes condition Hemoglobin O-Arab Trait
relationship: SCDO:1000196 SCDO:1000040 ! has contributing genetic variation HBB, GLU121LYS
relationship: SCDO:1000222 SCDO:1000016 ! causes molecular phenotype Hemoglobin O-Arab
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000229
name: Hemoglobin Genotype EE
def: "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 26 of beta-globin chains (hemoglobin E mutation) produced by both beta-globin gene (HBB) alleles." []
synonym: "beta6Glu>Lys / beta26Glu>Lys" EXACT []
synonym: "EE Genotype" EXACT []
synonym: "EE Hemoglobin Genotype" EXACT []
synonym: "Haemoglobin Genotype EE" EXACT []
synonym: "Hemoglobin E Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000530 ! causes condition Hemoglobin E Disease
relationship: SCDO:1000196 SCDO:1000042 ! has contributing genetic variation HBB, GLU26LYS
relationship: SCDO:1000222 SCDO:1000009 ! causes molecular phenotype Hemoglobin E
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000230
name: Hemoglobin Genotype DD
def: "The homozygous genotype that involves a hemoglobin D mutation in both beta-globin gene (HBB) alleles." []
synonym: "DD Genotype" EXACT []
synonym: "DD Hemoglobin Genotype" EXACT []
synonym: "Haemoglobin Genotype DD" EXACT []
synonym: "Hemoglobin C Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000524 ! causes condition Hemoglobin D Disease
relationship: SCDO:1000196 SCDO:1000108 ! has contributing genetic variation HBB, SER9TYR
relationship: SCDO:1000196 SCDO:1000109 ! has contributing genetic variation HBB, GLU121GLN
relationship: SCDO:1000196 SCDO:1000110 ! has contributing genetic variation HBB, GLY16ARG
relationship: SCDO:1000196 SCDO:1000111 ! has contributing genetic variation HBB, ASN19LYS
relationship: SCDO:1000196 SCDO:1000112 ! has contributing genetic variation HBB, GLU22GLN
relationship: SCDO:1000196 SCDO:1000113 ! has contributing genetic variation HBB, GLU22VAL
relationship: SCDO:1000196 SCDO:1000114 ! has contributing genetic variation HBB, THR87LYS
relationship: SCDO:1000196 SCDO:1000115 ! has contributing genetic variation HBB, GLU121ALA
relationship: SCDO:1000222 SCDO:1000007 ! causes molecular phenotype Hemoglobin D
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000231
name: Hemoglobin Genotype O-Arab
def: "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 121 of beta-globin chains (hemoglobin O-Arab mutation) produced by both beta-globin gene (HBB) alleles." []
synonym: "beta121Glu>Lys / beta121Glu>Lys" EXACT []
synonym: "Haemoglobin Genotype O-Arab" EXACT []
synonym: "O-Arab Genotype" EXACT []
synonym: "O-Arab Hemoglobin Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000544 ! causes condition Hemoglobin O-Arab Disease
relationship: SCDO:1000196 SCDO:1000040 ! has contributing genetic variation HBB, GLU121LYS
relationship: SCDO:1000222 SCDO:1000016 ! causes molecular phenotype Hemoglobin O-Arab
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000232
name: Hemoglobin Genotype CC
def: "The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 6 of beta-globin chains (hemoglobin C mutation) produced by both beta-globin gene (HBB) alleles." []
synonym: "beta6Glu>Lys / beta6Glu>Lys" EXACT []
synonym: "CC Genotype" EXACT []
synonym: "CC Hemoglobin Genotype" EXACT []
synonym: "Haemoglobin Genotype CC" EXACT []
synonym: "Hemoglobin C Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000519 ! causes condition Hemoglobin C Disease
relationship: SCDO:1000196 SCDO:1000041 ! has contributing genetic variation HBB, GLU6LYS
relationship: SCDO:1000222 SCDO:0000513 ! causes molecular phenotype Hemoglobin C
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000233
name: Hemoglobin Genotype M
def: "The presence of an amino acid substitution in either an alpha-, beta-, or gamma-globin chain such that its proximity to the heme iron in the hemoglobin molecule results in facilitated oxidation of the hemoglobin to yield excess methemoglobin. This can occur in either one or both alleles of the effected gene." []
synonym: "Haemoglobin Genotype M" EXACT []
synonym: "Hemoglobin M Genotype" EXACT []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 SCDO:0000541 ! causes condition Hemoglobin M Disease
relationship: SCDO:1000196 SCDO:1000238 ! has contributing genetic variation CYB5R3 Mutation
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 "a3"
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006449
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000234
name: obsolete - Hemoglobin M trait Genotype
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000303 "Hemoglobin M Disease is autosomal dominant, thus does not seem to have a \"trait\" condition." xsd:string
is_obsolete: true

[Term]
id: SCDO:1000235
name: Hereditary Persistence of Fetal Hemoglobin Genotype
def: "Either homozygosity or heterozygosity for the HPFH1 mutation, a 106-KB deletion in the beta globin gene cluster." []
is_a: SCDO:0004061 ! Genotype
relationship: RO:0003303 NCIT:C129072 ! causes condition Hereditary Persistence of Fetal Hemoglobin
relationship: SCDO:1000196 SCDO:0006860 ! has contributing genetic variation HBG1 and/or HBG2 Mutations
relationship: SCDO:1000196 SCDO:1000063 ! has contributing genetic variation HBB, 106-KB DEL
relationship: SCDO:1000222 HP:0011904 ! causes molecular phenotype Increased Hemoglobin F
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/603615
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000236
name: Hemoglobin Lepore Boston Genotype
def: "The homozygous genotype for Hemoglobin Lepore Boston that involves a crossover between both sets of delta (HBD) and beta globin (HBB) gene loci during meiosis." []
is_a: SCDO:0007624 ! Beta Thalassemia Genotype
relationship: RO:0003303 SCDO:0000536 ! causes condition Hemoglobin Lepore Boston Disease
relationship: SCDO:1000196 SCDO:1000209 ! has contributing genetic variation Crossover between delta (HBD) and beta globin (HBB) gene loci
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000237
name: Hemoglobin C-Harlem Trait
def: "The inheritance of one normal HBB gene along with an abnormal HBB gene that contains two amino acid substitutions, namely Glu6Val (HbS) and Asp73Asn." []
comment: Erythrocytes from persons with Hb CH trait show some sickling in hypertonic saline without deoxygenation; this finding and the renal functional abnormalities are similar to those seen in persons with sickle cell trait and suggest that the renal concentrating defects in the two disorders have similar pathogeneses.
synonym: "Hb CH-Trait" EXACT []
is_a: NCIT:C95534 ! Hemoglobin Trait
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://annals.org/aim/article-abstract/681956/clinical-features-hemoglobin-c-harlem-new-sickling-hemoglobin-variant
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin Trait\"." xsd:string
property_value: SCDO:0000340 https://annals.org/aim/article-abstract/681956/clinical-features-hemoglobin-c-harlem-new-sickling-hemoglobin-variant
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000238
name: CYB5R3 Mutation
def: "A mutation in the NADH-Cytochrome b5 Reductase 3 gene, CYB5R3, that contributes to the presence of methemoglobinemia (type I or II)." []
synonym: "DIA 1 Mutation" EXACT []
synonym: "Diaphorase Mutation" EXACT []
synonym: "Methemoglobinemia Mutation" EXACT []
synonym: "NADH-Cytochrome b5 Reductase 3 Mutation" EXACT []
is_a: IDOMAL:50000026 ! Mutation
relationship: SCDO:1000184 SCDO:1000233 ! contributes to genotype Hemoglobin Genotype M
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000239
name: Heterozygous Deletion of HBA1 or HBA2
def: "Deletion of one alpha-globin gene, either an HBA1 or HBA2 gene, which results in Alpha Thalassemia Silent (the person with the mutation is a silent carrier)." []
is_a: SCDO:0001386 ! Alpha-Globin Locus Deletion
relationship: SCDO:1000184 SCDO:1000221 ! contributes to genotype Alpha Thalassemia Silent Genotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000240
name: Reduced or Absent Hemoglobin A
def: "Either a decrease in the proportion of hemoglobin A to below 96-98% of all hemoglobin, or a complete lack of hemoglobin A production." []
is_a: SCDO:1000061 ! Altered Level of Normal Hemoglobin in SCD
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably too specific to be added to existing ontologies?" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000241
name: Absent Hemoglobin A
def: "A lack of production of normal adult hemoglobin." []
synonym: "Hemoglobin A Absent" EXACT []
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
is_a: SCDO:1000061 ! Altered Level of Normal Hemoglobin in SCD
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into HPO below \"Abnormal Hemoglobin Concentration\"." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000242
name: Autosomal Recessive Homozygous
def: "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are homozygotes (having two copies of the same mutant allele)." []
synonym: "Autosomal Homozygous Recessive Inheritance" EXACT []
is_a: HP:0000007 ! Autosomal Recessive
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000243
name: Autosomal Recessive Compound Heterozygous
def: "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." []
synonym: "Autosomal Recessive Compound Heterozygous Inheritance" EXACT []
is_a: HP:0000007 ! Autosomal Recessive
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000244
name: Sickle Cell Trait with a Severe Pyruvate Kinase Deficiency
def: "A sickle cell disease phenotype in which an individual heterozygous for hemoglobin S also has a severe pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling." []
is_a: SCDO:1000211 ! Dominant Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/19758413/
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/9886305
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000247
name: L-Glutamine Oral Powder
def: "A powder form of the optically active form of glutamine having L-configuration; to be administered orally." []
comment: Oral administration of L-glutamine oral powder is approved by the FDA to reduce the acute complications of sickle cell disease and sickle beta zero-thalassemia in adult and pediatric patients.
synonym: "Glutamine Oral Powder" EXACT []
synonym: "Glutamine Oral Powder Product" EXACT []
synonym: "Glutamine Powder" EXACT []
synonym: "L-Glutamine Powder" EXACT []
synonym: "Oral Glutamine" EXACT []
is_a: CHEBI:23888 ! Drug
is_a: SCDO:0001133 ! Symptomatic Therapeutics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm566097.htm
property_value: SCDO:0000303 "Suggest update to description in the Drug Ontology (DRON) for \"Glutamine Oral Powder\" (currently no description provided)." xsd:string
property_value: SCDO:0000340 CHEBI:18050
property_value: SCDO:0000340 https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm566097.htm
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000250
name: deprecated Abnormal Molecular Function
def: "A phenotype in which a specific molecular function is abnormal." []
xref: FYPO:0000707
is_a: SCDO:0000359 ! deprecated terms
property_value: SCDO:0000340 FYPO:0000707
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000250 xsd:string
is_obsolete: true

[Term]
id: SCDO:1000251
name: Increased Red Cell Osmotic Fragility
def: "An increase in red blood cell sensitivity to change in osmotic pressure. More specifically, the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to osmotic stress by being placed in a hypotonic solution." []
synonym: "Increased Erythrocyte Osmotic Fragility" EXACT []
synonym: "Increased Red Cell Fragility" EXACT []
xref: HP:0005502
is_a: HP:0020054 ! Abnormal Erythrocyte Physiology
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "What is normal osmotic fragility? Perhaps this can be included in the description.\n\nSuggest update to description in the HPO. Currently no description given.\n\nInclude \"Osmotic Fragility Test\" in an appropriate location below \"Diagnostics Tools\" and link to this term." xsd:string
property_value: SCDO:0000340 Erythrocyte:fragility
property_value: SCDO:0000340 HP:0005502
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/MESH?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD009996
property_value: SCDO:1000288 "Suggest update to description." xsd:string

[Term]
id: SCDO:1000252
name: Increased Red Cell Osmotic Resistance
xref: HP:0005546
is_a: HP:0020054 ! Abnormal Erythrocyte Physiology
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC439273/?page=1
property_value: SCDO:0000303 "Is this not the same as \"Increased Red Cell Osmotic Fragility\"? See dc:source provided.\n\nWhat is normal osmotic resistance? Perhaps this can be included in the description.\n\nSuggest update to description in the HPO. Currently no description given.\n\nInclude \"Osmotic Fragility Test\" in an appropriate location below \"Diagnostics Tools\" and link to this term." xsd:string
property_value: SCDO:0000340 HP:0005546
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000253
name: Abnormal Biological Process
def: "A situation in which a specific biological process within an organism is abnormal." []
xref: FYPO:0005447
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000303 "Include here \"Intrahepatic Sinusoidal\nSickling\"? See paper \"Liver involvement in sickle cell disease\" by Emel GÜRKAN et al." xsd:string
property_value: SCDO:0000340 FYPO:0005447
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000253 xsd:string

[Term]
id: SCDO:1000254
name: Polymerisation of Hemoglobin
def: "When deoxygenated, malfunctioning or mutated hemoglobins clump together and form a long polymer." []
synonym: "Hemoglobin Polymerisation" EXACT []
is_a: SCDO:1000253 ! Abnormal Biological Process
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000340 scd:background.html
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000255
name: Guidelines on Red Cell Transfusion in Sickle Cell Disease - Part II: Indications for Transfusion
def: "Guidelines that examine current available evidence on indications for transfusion in sickle cell disease." []
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Br J Haematol. 2017 Jan;176(2):192-209. doi: 10.1111/bjh.14383. Epub 2016 Nov 18." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000256
name: Sickle Cell Acute Painful Episode - Management of an Acute Painful Sickle Cell Episode in Hospital
def: "This guideline addresses the management of an acute painful sickle cell episode in patients presenting to hospital until discharge. This includes the use of pharmacological and non-pharmacological interventions, identifying the signs and symptoms of acute complications, skills and settings for managing an acute painful episode, and the information and support needs of patients." []
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.bmj.com/content/344/bmj.e4063.full
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pubmed/23534086
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000257
name: Three Tips About Sickle Cell Disease Every Emergency Provider Needs to Know
def: "A factsheet that shares steps to improve care in emergency departments (ED) of hospitals and clinics for people with sickle cell disease (SCD). It was created to help improve healthcare in the ED for patients with SCD." []
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 https://f2fmichigan.org/resource/three-tips-about-sickle-cell-disease-every-emergency-provider-needs-to-know/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000258
name: Practice Guidelines: Management of Pain in Sickle Cell Disease
def: "A comprehensive guideline to aid physicians and other health care professionals in the management of patients with acute and chronic pain associated with sickle cell disease (SCD). The guideline covers the following information: an overview of the disease, the types and characteristics of pain associated with the disease, recommendations for pain assessment, methods for treatment of pain and a discussion of pain in the various developmental stages. It also includes discussions of pain assessment instruments." []
is_a: SCDO:1000143 ! Disease Management Guideline
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Probably not necessary to include in other ontologies." xsd:string
property_value: SCDO:0000340 "Am Fam Physician. 2000 Mar 1;61(5):1544-1550." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000259
name: Unusual Hemoglobin
def: "A hemoglobin that shows characteristics of an abnormal hemoglobin, but its inheritance does not accompany any disability." []
synonym: "Unusual Hemoglobin Variant" EXACT []
is_a: SCDO:0006921 ! Hemoglobin Variant
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Hemoglobin Variant\"." xsd:string
property_value: SCDO:0000340 https://www.cabdirect.org/cabdirect/abstract/19652901458
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000260
name: Symptom Induced by Strenuous Exercise
def: "Any feeling of illness or physical or mental change that results from strenuous exercise." []
xref: OMIM:MTHU024836
is_a: HP:0000118 ! Abnormal Phenotype
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/OMIM/MTHU024836
property_value: http://purl.org/dc/elements/1.1/source https://dictionary.cambridge.org/dictionary/english/symptom
property_value: SCDO:0000303 "Suggest update to description in OMIM (currently no description provided)." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000261
name: Avitaminosis
def: "A condition due to a deficiency of one or more essential vitamins. (Dorland, 27th ed)" []
synonym: "Vitamin Deficiencies" EXACT []
synonym: "Vitamin Deficiency" EXACT []
xref: MESH:D001361
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D001361
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000261 xsd:string

[Term]
id: SCDO:1000268
name: Abnormality of the Musculature
def: "Abnormality originating in one or more muscles of the set of muscles in the body." []
xref: HP:0003011
is_a: HP:0000118 ! Abnormal Phenotype
property_value: SCDO:0000340 HP:0003011
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000276
name: Abnormal Hemoglobin Level in SCD
def: "An abnormal level of hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD)." []
is_a: SCDO:1000060 ! SCD Molecular Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Probably too specific to SCD be included in other ontologies." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000280
name: Transfusion Hemochromatosis
def: "Hemochromatosis that results from repeated blood transfusions." []
synonym: "Transfusion Haemochromatosis" EXACT []
synonym: "Transfusion-Induced Iron Overload" EXACT []
is_a: SCDO:1000281 ! Secondary Hemochromatosis
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000281
name: Secondary Hemochromatosis
def: "An acquired metabolic disorder characterized by iron accumulation in the tissues." []
is_a: NCIT:C78393 ! Iron Overload
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Suggest inclusion into existing ontology." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000289
name: Hemoglobin D-Punjab Present
def: "When the abnormal hemoglobin, hemoglobin D-Punjab (Hb D-Punjab), has been detected in a blood sample." []
synonym: "Haemoglobin D-Punjab in Blood" EXACT []
synonym: "Haemoglobin D-Punjab Present" EXACT []
synonym: "Hb D-Punjab in Blood" EXACT []
synonym: "Hb D-Punjab Present" EXACT []
synonym: "Hemoglobin D-Punjab in Blood" EXACT []
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000290
name: Hemoglobin G-Philadelphia Present
def: "When the abnormal hemoglobin, hemoglobin G-Philadelphia (Hb G-Philadelphia), has been detected in a blood sample." []
synonym: "Haemoglobin G-Philadelphia in Blood" EXACT []
synonym: "Haemoglobin G-Philadelphia Present" EXACT []
synonym: "Hb G-Philadelphia in Blood" EXACT []
synonym: "Hb G-Philadelphia Present" EXACT []
synonym: "Hemoglobin G-Philadelphia in Blood" EXACT []
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000291
name: Hemoglobin O-Arab Present
def: "When the abnormal hemoglobin, hemoglobin O-Arab (Hb O-Arab), has been detected in a blood sample." []
synonym: "Haemoglobin O-Arab in Blood" EXACT []
synonym: "Haemoglobin O-Arab Present" EXACT []
synonym: "Hb O-Arab in Blood" EXACT []
synonym: "Hb O-Arab Present" EXACT []
synonym: "Hemoglobin O-Arab in Blood" EXACT []
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000292
name: Normal Hemoglobin F Level
def: "When the level of hemoglobin F detected in a sample of blood falls in the normal range for HbF." []
synonym: "Normal Haemoglobin F Level" EXACT []
synonym: "Normal HbF Level" EXACT []
synonym: "Normal Hemoglobin F Concentration" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000295
name: Quality of Life Assessment Score
def: "The score obtained from a quality of life-related diagnostic instrument." []
synonym: "Quality of Life Score" EXACT []
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000296
name: ASCQ-Me Score
def: "The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me) diagnostic instrument." []
synonym: "ASCQ-Me - Quality of Life in SCD Score" EXACT []
synonym: "Sickle Cell Disease Adult Quality of Life Questionnaire Assessment Score" EXACT []
is_a: SCDO:1000295 ! Quality of Life Assessment Score
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://www.phenxtoolkit.org/index.php?pageLink=browse.protocoldetails&id=820201
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000297
name: Quality of Life and Care Diagnostic Instrument
def: "A diagnostic instrument that involves an assessment of quality of life- and/or quality of care-related elements." []
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000298
name: Hepatitis B Virus Surface Antigen Test
def: "A deteremination of the presence of hepatitis B virus surface antigen." []
comment: If a person tests “positive,” then further testing is needed to determine if this is a new “acute” infection or a “chronic” hepatitis B infection. \n\nA positive HBsAg test result means that you are infected and can spread the hepatitis B virus to others through your blood.
synonym: "HBSAG Test" EXACT []
synonym: "HBsAg Test" EXACT []
synonym: "Hepatitis B Surface Antigen Test" EXACT []
synonym: "Hepatitis B Virus Surface Antigen Measurement" EXACT []
xref: NCIT:C64850
is_a: SCDO:0000616 ! Immunochemical Assay
property_value: http://purl.org/dc/elements/1.1/source http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Surface Antigen Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C64850&jump_to_nav=true
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000299
name: Hepatitis B Surface Antibody Test
def: "The determination of the surface antibody reaction of a sample to the Hepatitis B virus." []
comment: http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
synonym: "anti-HBs Test" EXACT []
synonym: "HBSAB Test" EXACT []
synonym: "HBsAb Test" EXACT []
synonym: "Hepatitis B Virus Surface Antibody Test" EXACT []
xref: NCIT:C74711
is_a: SCDO:1000302 ! Hepatitis B Virus Antibody Test
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis B Surface Antibody Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C74711
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000300
name: Hepatitis B Core Antibody Test
def: "The determination of the amount of Hepatitis B virus core antibody present in a sample." []
comment: A "positive" or "reactive" anti-HBc (or HBcAb) test result indicates a past or current hepatitis B infection. \n\nThe core antibody does not provide any protection against the hepatitis B virus (unlike the surface antibod). This test can only be fully understood by knowing the results of the HBsAg and anti-HBs tests.\n\nA positive anti-HBc (or HBcAb) test result requires talking to your health care provider for a complete explanation of your hepatitis B status.
synonym: "Anti-HBc Test" EXACT []
synonym: "HBCAB Test" EXACT []
synonym: "HBcAB Test" EXACT []
synonym: "Hepatitis B Virus Core Antibody Test" EXACT []
xref: NCIT:C96660
is_a: SCDO:1000302 ! Hepatitis B Virus Antibody Test
property_value: http://purl.org/dc/elements/1.1/source http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
property_value: SCDO:0000303 "Suggest update to label in nCIT (from \"Hepatitis B Virus Core Antibody Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C96660&jump_to_nav=true
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000301
name: Hepatitis B Blood Panel
def: "A set of three blood tests (Hepatitis B Core Antibody Test, Hepatitis B Surface Antibody Test, and Hepatitis B Virus Surface Antigen Test) needed to fully understand whether a person is infected with Hepatitis B or not." []
synonym: "Hepatitis B Panel" EXACT []
synonym: "Hepatitis B Panel of Blood Tests" EXACT []
is_a: SCDO:0000616 ! Immunochemical Assay
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000302
name: Hepatitis B Virus Antibody Test
def: "The determination of the amount of hepatitis B virus antibody present in a sample." []
synonym: "HBAB Test" EXACT []
synonym: "Hepatitis B Antibody Test" EXACT []
xref: NCIT:C125944
is_a: SCDO:0000616 ! Immunochemical Assay
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Antibody Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C125944
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000303
name: Hepatitis B Core IgG Antibody Test
def: "The determination of the amount of hepatitis B virus core IgG antibody in a biological specimen." []
synonym: "HBCIGGAB Test" EXACT []
synonym: "Hepatitis B Virus Core IgG Antibody Test" EXACT []
xref: NCIT:C119280
is_a: SCDO:1000300 ! Hepatitis B Core Antibody Test
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Core IgG Antibody Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C119280
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000304
name: Hepatitis B Core IgM Antibody Test
def: "The determination of the amount of Hepatitis B virus core IgM antibody present in a sample." []
synonym: "HBCIGMAB Test" EXACT []
synonym: "Hepatitis B Virus Core IgM Antibody Test" EXACT []
xref: NCIT:C96661
is_a: SCDO:1000300 ! Hepatitis B Core Antibody Test
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis B Virus Core IgM Antibody Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C96661
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000305
name: Pulse Oximetry (Exercise)
def: "Exercise testing for evaluation of hypoxemia and/or desaturation that occurs on exertion." []
xref: phenX:91001
is_a: NCIT:C38085 ! Pulse Oximetry
property_value: SCDO:0000303 "Suggest inclusion of term below \"Pulse Oximetry\" in the CMO." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/91001
property_value: SCDO:0000479 "PhenX protocol: Pulse Oximetry (Exercise) #91001" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000305 xsd:string

[Term]
id: SCDO:1000306
name: Hepatitis C Virus Antigen Test
def: "The determination of the amount of hepatitis C virus antigen present in a sample." []
synonym: "HCAG Test" EXACT []
synonym: "Hepatitis C Virus Antigen Measurement" EXACT []
xref: NCIT:C116196
is_a: SCDO:0000616 ! Immunochemical Assay
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis C Virus Antigen Measurement\"" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C116196
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000307
name: Hepatitis C Antibody Test
def: "A determination of the presence of the hepatitis C virus antibody in a biological specimen." []
synonym: "HCAB Test" EXACT []
synonym: "Hepatitis C Antibody Measurement" EXACT []
synonym: "Hepatitis C Virus Antibody Test" EXACT []
xref: NCIT:C92535
is_a: SCDO:0000616 ! Immunochemical Assay
property_value: SCDO:0000303 "Suggest update to label and description in NCIT (from \"Hepatitis C Antibody Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C92535
property_value: SCDO:1000288 "Suggest update to label and description" xsd:string

[Term]
id: SCDO:1000308
name: Hepatitis C Virus Core Antigen Test
def: "The determination of the amount of hepatitis C virus core antigen in a biological sample." []
synonym: "HCCAG Test" EXACT []
synonym: "HCV Core Antigen Measurement" EXACT []
synonym: "HCV Core Antigen Test" EXACT []
synonym: "Hepatitis C Core Antigen Test" EXACT []
synonym: "Hepatitis C Virus Core Antigen Measurement" EXACT []
xref: NCIT:C135424
is_a: SCDO:1000306 ! Hepatitis C Virus Antigen Test
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis C Virus Core Antigen Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C135424&jump_to_nav=true
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000309
name: Hepatitis C Surface Antibody Test
def: "The determination of the surface antibody reaction of a sample to the Hepatitis C virus." []
synonym: "Hepatitis C Surface Antibody Measurement" EXACT []
xref: NCIT:C74712
is_a: SCDO:1000307 ! Hepatitis C Antibody Test
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Hepatitis C Surface Antibody Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT/?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C74712&jump_to_nav=true
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000310
name: Cystatin C Blood Test
def: "The determination of the amount of cystatin C present in a sample." []
synonym: "CYSTATC Blood Test" EXACT []
xref: NCIT:C92290
is_a: SCDO:0000133 ! Blood Test
is_a: SCDO:0000676 ! Kidney Function Test
relationship: SCDO:1000194 SCDO:0000310 ! measures Blood Cystatin C Level
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Cystatin C Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C92290
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000313
name: Diagnostic Device Visual Output
def: "The visual output that a specific diagnostic device produces." []
synonym: "Visual Output of a Diagnostic Device" EXACT []
is_a: SCDO:0000379 ! Diagnostics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000314
name: Red Blood Cell Microparticles Assay
def: "A bioassay to measure levels of red blood cell microparticles." []
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1000194 SCDO:0000975 ! measures Red Blood Cell Microparticles Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000315
name: Serum HDL Cholesterol Test
def: "A quantitative measurement of the amount of HDL cholesterol present in a sample of serum." []
synonym: "Serum HDL Cholesterol Measurement" EXACT []
xref: NCIT:C61041
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1000194 SCDO:0001043 ! measures Serum HDL Cholesterol Level
property_value: SCDO:0000303 "Suggest update to label in NCIT (from \"Serum HDL Cholesterol Measurement\")" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C61041
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000316
name: Blood Flow Test
def: "A technique used to measure velocity and amount of blood flow and circulation in the living system." []
is_a: SCDO:0000902 ! Physiological Assay
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000317
name: Heart Measurement
def: "Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart." []
xref: CMO:0000670
is_a: CMO:0000001 ! Cardiovascular Measurement
property_value: SCDO:0000303 "Suggest this description for this term in  the CMO (it was recently described separately from another similar term\" but's it's definition has not yet been ascribed)." xsd:string
property_value: SCDO:0000340 CMO:0000670
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000318
name: Diagnostic Instrument Measurement
def: "An information entity, used in the diagnosis of medical conditions, that is a recording of the output of a diagnostic instrument." []
synonym: "Diagnostic Instrument Outcome" EXACT []
is_a: SCDO:0000728 ! Diagnostic Measurement
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nAdd terms/Variables obtained from:\nHistory of Head Trauma Diagnostic Instrument" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000319
name: Cigarette Smoking Status Diagnostic Instrument
def: "Questions asking the respondent about smoking status in his or her entire life." []
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/30604
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000320
name: Cigarette Smoking Status Diagnostic Instrument - Adult
def: "Questions asking an adult respondent about smoking status in his or her entire life." []
is_a: SCDO:1000319 ! Cigarette Smoking Status Diagnostic Instrument
relationship: SCDO:1000194 SCDO:0000235 ! measures Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30604
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000479 "PhenX protocol: Cigarette Smoking Status - Adult #30604" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000321
name: Cigarette Smoking Status Diagnostic Instrument - Adolescent
def: "Questions asking an adolescentt respondent about smoking status in his or her entire life." []
is_a: SCDO:1000319 ! Cigarette Smoking Status Diagnostic Instrument
relationship: SCDO:1000194 SCDO:0000235 ! measures Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30603
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:0000479 "PhenX protocol: Cigarette Smoking Status - Adolescent #30603" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000322
name: Never Smoker
def: "A person who has never smoked a cigarette, not even one or two puffs." []
is_a: SCDO:0000235 ! Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30604
property_value: SCDO:0000303 "Other ontologies define this as \"A person who was not smoking at the time of the interview and has smoked less than 100 cigarettes in their life.\"" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000323
name: Current Every-Day Smoker
def: "A person who was smoking on a daily basis at the time of the interview." []
is_a: SCDO:0000235 ! Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30604
property_value: SCDO:0000303 "Other ontologies define this as \"Indicates a person who has smoked at least 100 cigarettes in his or her lifetime and who currently smokes every day.\"" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000324
name: Current Some-Day Smoker
def: "A person who had smoked a cigarette in the past, and was smoking on some days, but not daily, at the time of the interview." []
is_a: SCDO:0000235 ! Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30604
property_value: SCDO:0000303 "Other ontologies define this as \"Indicates a person who has smoked at least 100 cigarettes in his or her lifetime, who smokes now, but does not smoke every day.\"" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000325
name: Former Smoker
def: "A person who was not smoking at the time of the interview but has smoked a cigarette in the past, even if just one or two puffs" []
is_a: SCDO:0000235 ! Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30604
property_value: SCDO:0000303 "Other ontologies define this as \"A person who was not smoking at the time of the interview but has smoked at least 100 cigarettes in their life.\"" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000326
name: Ever-Smoker
def: "A person who has smoked a cigarette in the past, even if just one or two puffs, but was unable to or refused to answer when asked when the last time was that they smoked a cigarette, even one or two puffs." []
is_a: SCDO:0000235 ! Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30603
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000327
name: Past 30-Day Smoker
def: "A person who had smoked in the past 30 days at the time of the interview, but who had not smoked every day of the past 30 days." []
is_a: SCDO:0000235 ! Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30603
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000328
name: Past 30-Day Every-Day Smoker
def: "A person who had smoked every day of the past 30 days at the time of the interview." []
is_a: SCDO:0000235 ! Cigarette Smoking Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/30603
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000329
name: Alcohol - Lifetime Use Diagnostic Instrument
def: "Question asking the respondent if s/he has ever consumed any alcoholic beverage during his or her entire life." []
xref: phenX:030100
is_a: SCDO:1000474 ! Clinical or Research Assessment Data Element
relationship: SCDO:1000194 SCDO:0000038 ! measures Alcohol - Lifetime Use
property_value: SCDO:0000303 "Suggest update to label in PhenX" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F030100
property_value: SCDO:0000479 "PhenX protocol: #30101" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000330
name: Epilepsy Screener - Adult
def: "A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in adults." []
synonym: "Epilepsy Screener for Adults" EXACT []
xref: phenX:130401
is_a: SCDO:0000440 ! Epilepsy Screener
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into \"PhenX Phenotypic Terms\".\nThis is in the PhenX toolkit but not in the ontology in BioPortal. It should probably be included there." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/130401
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000331
name: Epilepsy Screener - Child/Proxy
def: "A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in family members, including children and those who are deceased." []
synonym: "Family History of Epilepsy Screening Interview" EXACT []
synonym: "Ottman Brief Epilepsy Screener - Proxy-reported Version" EXACT []
xref: phenX:130402
is_a: SCDO:0000440 ! Epilepsy Screener
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into \"PhenX Phenotypic Terms\".\nThis is in the PhenX toolkit but not in the ontology in BioPortal. It should probably be included there." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/130402
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000332
name: Executive Dysfunction
def: "A disruption to the efficacy of the executive functions, which is a group of cognitive processes that regulate, control, and manage other cognitive processes." []
synonym: "Defects in Executive Function" EXACT []
synonym: "Executive Function Deficit" EXACT []
is_a: HP:0000708 ! Behavioural Abnormality
relationship: SCDO:0000663 SCDO:0001304 ! diagnosed using tool Executive Function Measure
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Perhaps below \"Behavioral Abnormality\" in the HPO." xsd:string
property_value: SCDO:0000340 Executive:dysfunction
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000333
name: Global Mental Status Screener - Child
def: "A series of 21 age-specific questionnaires and scoring sheets designed to screen a child's skills in five developmental areas: fine motor, gross motor, problem solving, communication, and personal-social. A child's scores for each area are compared to cut-off scores to determine a need for monitoring or further assessment." []
synonym: "The Ages & Stages Questionnaires, Third Edition (ASQ-3)" EXACT []
is_a: SCDO:0000455 ! Global Mental Status Screener
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Maybe below \"Clinical or Research Assessment Questionnaire\" in the NCIT." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/130702
property_value: SCDO:0000479 "Global Mental Status Screener - Child #130702" xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000336
name: Frequency of Sickle Cell Pain Episodes
def: "The frequency of acute pain episodes due to sickle cell disease (SCD)." []
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
relationship: SCDO:1000190 SCDO:0000725 ! obtained via diagnostic tool Measure of Frequency of Sickle Cell Pain Episodes
property_value: SCDO:0000303 "Request inclusion into relevant ontology\n\nAdd as sub-classes: (from protocol questions)\n- a term for the number of times an emergency room was visited because of a sickle cell painful event in the last 6 months\n- a term for the number of times the person was admitted to a hospital because of a sickle cell painful event in the last 12 months" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell. This term in PhenX currently refers to a diagnostic instrument." xsd:string

[Term]
id: SCDO:1000337
name: Substances - Lifetime Use Diagnostic Instrument
def: "Questions from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) related to their lifetime use of illicit and prescribed substances." []
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
relationship: SCDO:1000194 SCDO:0001121 ! measures Substances - Lifetime Use
property_value: SCDO:0000303 "Suggest update to label in PhenX" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/31102
property_value: SCDO:0000479 "PhenX protocol: Substances - Lifetime Use #31102" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000338
name: Sleep Disorders Screener - Children
def: "A 26-item, self-administered scale completed by the parent that assesses the child's sleep behaviors in the past 6 months. The scale includes six subscales: disorders of initiating and maintaining sleep (items 1, 2, 3, 4, 5, 10, 11); sleep breathing disorders (items 13, 14, 15); disorders of arousal (items 17, 20, 21); sleep-wake transition disorders (items 6, 7, 8, 12, 18, 19); disorders of excessive somnolence (items 22, 23, 24, 25, 26); and sleep hyperhidrosis (score of the items 9, 16). Each item is rated on a 5-point, Likert-type scale (1 = Never; 5 = Always [daily]). Scores from individual items of each subscale are added together to give a subscale score, with higher scores indicating greater symptoms. Scores from the individual subscales can be added together to give a total score." []
synonym: "Sleep Disturbances Scale for Children" EXACT []
xref: phenX:121002
is_a: SCDO:1000348 ! Sleep Disorders Screener
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology. \nSeparate adult vs children instruments not shown in \"PhenX Phenotypic Terms\"." xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/121002
property_value: SCDO:0000479 "PhenX protocol: Sleep Disorders Screener - Children #121002" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000339
name: History of Head Trauma
def: "A record of an individual's background in regard to head trauma." []
is_a: NCIT:C18772 ! Personal Medical History
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology. Perhaps as a sub-class of \"History of Trauma\" in \"The Stroke Ontology\"?\n\nPhenX uses this as their label for a questionnaire, but we're going to suggest they change that. Otherwise, don't see it in other ontologies." xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000340
name: History of Stroke
def: "A record of an individual's history of stroke(s) and associated symptoms such as slurred speech, double vision, loss of vision, and paralysis." []
is_a: NCIT:C18772 ! Personal Medical History
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Personal Medical History\". Note: Is present in The Stroke Ontology." xsd:string
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000341
name: History of Kidney Failure
def: "A record of an individual's history of kidney failure." []
is_a: NCIT:C18772 ! Personal Medical History
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT as a sub-class of \"Personal Medical History\".\n\nPhenX uses this as their label for a questionnaire, but we're going to suggest they change that. Otherwise, don't see it in other ontologies." xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000342
name: History of Transfusion Diagnostic Instrument
def: "A questionnaire to assess history of transfusion." []
xref: phenX:830200
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
relationship: SCDO:0001297 NCIT:C17357 ! has essential measure Gender
relationship: SCDO:0001297 SCDO:0000304 ! has essential measure Current Age
property_value: SCDO:0000303 "Suggest update to label as we have done. We are using \"History of Transfusion\" below Personal Attribute." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F830200
property_value: SCDO:0000479 "PhenX protocol: History of Transfusion #830201" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000343
name: History of Type 1 and Type 2 Diabetes
def: "A record of an individual's history of type 1 and type 2 diabetes." []
is_a: NCIT:C18772 ! Personal Medical History
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT as a sub-class of \"Personal Medical History\".\n\nPhenX uses this as their label for a questionnaire, but we're going to suggest they change that. Otherwise, don't see it in other ontologies." xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000344
name: Reproductive History Diagnostic Instrument - Male
def: "A questionnaire to assess males' pregnancy history." []
is_a: SCDO:0000987 ! Reproductive History Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/101302
property_value: SCDO:0000303 "Suggest update to label and description in PhenX as we have done. We are using \"Reproductive History\" below Personal Attribute." xsd:string
property_value: SCDO:0000479 "PhenX protocol: Reproductive History - Male #101302" xsd:string
property_value: SCDO:1000288 "Suggest update to label and description." xsd:string

[Term]
id: SCDO:1000345
name: Reproductive History Diagnostic Instrument - Female
def: "A questionnaire to assess females' pregnancy history." []
is_a: SCDO:0000987 ! Reproductive History Diagnostic Instrument
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/101301
property_value: SCDO:0000303 "Suggest update to label and description in PhenX as we have done. We are using \"Reproductive History\" below Personal Attribute." xsd:string
property_value: SCDO:0000479 "PhenX protocol: Reproductive History - Female #101301" xsd:string
property_value: SCDO:1000288 "Suggest update to label and description." xsd:string

[Term]
id: SCDO:1000348
name: Sleep Disorders Screener
def: "A questionnaire to assess sleep disorders, a broad group of disorders that can be caused by endogenous disturbances in the sleep-wake or timing cycles (American Psychiatric Association, 2000)." []
xref: phenX:121000
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
is_a: SCDO:1000033 ! Diagnostic Instrument
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/PHENX/?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FphenX%2F121000&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000348 xsd:string

[Term]
id: SCDO:1000350
name: Heart Valve Function Test
def: "A test to assess the structure and function of the heart valves." []
xref: phenX:40501
is_a: SCDO:0000500 ! Heart Function Test
relationship: SCDO:1000194 SCDO:0000502 ! measures Heart Valve Measurement
property_value: SCDO:0000303 "Suggest update to label in PhenX (from \"Heart Valve Function\")" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/40501
property_value: SCDO:0000479 "PhenX protocol: Heart Valve Function #40501" xsd:string
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000352
name: Spirometry - Adult
def: "Measurement of the breathing capacity of an adult's lung by means of a spirometer." []
is_a: NCIT:C85397 ! Spirometry
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/91601
property_value: SCDO:0000303 "Suggest update to description in PhenX (currently the same for both adult and child protocols)" xsd:string
property_value: SCDO:0000479 "PhenX protocol: Spirometry - Adult #91601" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000353
name: Spirometry - Child
def: "Measurement of the breathing capacity of a child's lung by means of a spirometer." []
is_a: NCIT:C85397 ! Spirometry
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.phenxtoolkit.org/protocols/view/91602
property_value: SCDO:0000303 "Suggest update to description in PhenX (currently the same for both adult and child protocols)" xsd:string
property_value: SCDO:0000479 "PhenX protocol: Spirometry - Child #91602" xsd:string
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000354
name: Health Risk Behavior
def: "Pattern of behavior which predisposes certain individuals to increased risk for contracting disease or sustaining personal injury. These behaviors may cluster into a risky lifestyle." []
synonym: "Health Risk Behaviors" EXACT []
synonym: "Risky Health Behavior" EXACT []
synonym: "Risky Health Behaviors" EXACT []
xref: MESH:D000073599
is_a: SCDO:0000487 ! Health Behaviour
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000073599
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000354 xsd:string

[Term]
id: SCDO:1000355
name: Health Facility Environment
def: "Physical surroundings or conditions of a hospital or other health facility and influence of these factors on patients and staff." []
xref: MESH:D006272
is_a: ExO:0000048 ! Built Environment
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006272
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000355 xsd:string

[Term]
id: SCDO:1000356
name: Altitude
def: "Height above sea level or above the earth's surface." []
xref: CSP:1035-6505
is_a: SCDO:0000897 ! Physical Environment
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/CRISP/?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FCSP%2F1035-6505&jump_to_nav=true
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000356 xsd:string

[Term]
id: SCDO:1000357
name: Self Reported Educational Attainment
def: "A measure of educational progress reported using a questionnaire based approach, often used as a proxy for cognitive performance as the two are correlated." []
xref: EFO:0004784
is_a: SCDO:0000305 ! Current Educational Attainment
property_value: SCDO:0000340 http://www.ebi.ac.uk/efo/EFO:0004784
property_value: SCDO:0000479 "PhenX protocol: Current Educational Attainment #11001" xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000357 xsd:string

[Term]
id: SCDO:1000360
name: Globin Gene
def: "A gene that encodes one of the globin family proteins, which are globular heme-containing proteins and include androglobin, cryoglobin, hemoglobin subunits, myoglobin and neuroglobin." []
synonym: "Globin Gene Family" EXACT []
synonym: "Globin Genes" EXACT []
xref: NCIT:C142196
is_a: NCIT:C16612 ! Gene
property_value: SCDO:0000303 "Suggest update to description in NCIT." xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C142196
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000361
name: Alpha-Globin Gene
def: "A gene that provides instructions for making a protein called alpha-globin." []
is_a: SCDO:1000360 ! Globin Gene
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000362
name: Beta-Globin Gene
def: "A gene located in the beta-globin locus (or gene cluster) on chromosome 11." []
is_a: SCDO:1000360 ! Globin Gene
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Include sub-classes?:\nHBE1 (encodes hemoglobin subunit epsilon)\nHBG1\nHBG2\nHBM\nHBQ1\nHBZ" xsd:string
property_value: SCDO:0000303 "Should this perhaps rather be something like \"Beta-Globin Locus Gene\"? To prevent confusion with the HBB Gene.\n\nRequest inclusion into relevant ontology." xsd:string
property_value: SCDO:1000288 "Negligable" xsd:string

[Term]
id: SCDO:1000363
name: Hemoglobin Subunit Zeta
def: "A member of the alpha-globin family. In humans, it is encoded in the alpha-globin gene cluster or locus, located on chromosome 16. Two hemoglobin subunit zeta chains combine with two hemoglobin subunit epsilon chains to form the embryonic Hemoglobin Gower 1." []
synonym: "Haemoglobin Subunit Zeta" EXACT []
synonym: "Haemoglobin Zeta Chain" EXACT []
synonym: "HBAZ" EXACT []
synonym: "Hemoglobin Zeta Chain" EXACT []
synonym: "Zeta Globin" EXACT []
synonym: "Zeta-Globin" EXACT []
xref: MESH:D055543
is_a: SCDO:1000105 ! Alpha-Globin Family Members
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D055543
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000363 xsd:string

[Term]
id: SCDO:1000364
name: Hemoglobin A2
def: "An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia." []
synonym: "A2, Hemoglobin" EXACT []
synonym: "alpha2delta2" EXACT []
synonym: "HbA2" EXACT []
synonym: "Normal Variant of Hemoglobin A" EXACT []
xref: MESH:D006443
is_a: SCDO:0006835 ! Normal Hemoglobin
property_value: SCDO:0000303 "Request inclusion into NCIT below \"Hemoglobin\"/\"Normal Hemoglobin\"." xsd:string
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006443
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000364 xsd:string

[Term]
id: SCDO:1000366
name: Delta Beta Thalassemia Mutation
def: "A mutation that contributes to decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis." []
synonym: "Delta Beta Thalassaemia Mutation" EXACT []
is_a: SCDO:0009731 ! Beta Thalassemia Mutation
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000371
name: Prenatal Maternal Abnormality
def: "A health abnormality in a woman during pregnancy." []
synonym: "Maternal Health Problem" EXACT []
xref: HP:0002686
is_a: HP:0001197 ! Abnormality of Prenatal Development or Birth
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Suggest update to description in HP. Currently no description." xsd:string
property_value: SCDO:0000340 HP:0002686
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000376
name: Osteonecrosis of the Humeral Head
def: "In situ death of bone within the humeral head due to disruption of blood supply." []
synonym: "Aseptic Necrosis of the Humeral Head" EXACT []
synonym: "Avascular Necrosis of the Humeral Head" EXACT []
is_a: HP:0010885 ! Osteonecrosis
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into NCIT as sub-class of \"Avascular Necrosis of Humerus\"." xsd:string
property_value: SCDO:0000340 http://www.wheelessonline.com/ortho/Humeral_Head_Osteonecrosis
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000379
name: Culturally Competent Care
def: "Health care services that are respectful of and responsive to the health beliefs, practices and cultural and linguistic needs of diverse patients. The provider and the patient each bring their individual learned patterns of language and culture to the health care experience which must be transcended to achieve equal access and quality health care." []
synonym: "Care, Culturally Congruent" EXACT []
synonym: "Culturally Congruent Care" EXACT []
xref: MESH:D065246
is_a: SCDO:0000246 ! Clinical Competence
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D065246
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000379 xsd:string

[Term]
id: SCDO:1000383
name: Renal Complication
def: "Any kidney disorder occurring as a consequence of injury to the kidney." []
synonym: "Kidney Complication" EXACT []
is_a: NCIT:C2959 ! Complication
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000392
name: Sp1 Transcription Factor
def: "Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES." []
synonym: "Transcription Factor, Sp1" EXACT []
xref: MESH:D016329
is_a: NCIT:C26548 ! Gene Product
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016329
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000392 xsd:string

[Term]
id: SCDO:1000394
name: Gene Component
def: "A gene component is a component of a gene." []
xref: SIO:010444
is_a: SCDO:0005722 ! Genetic Structure
property_value: SCDO:0000340 SIO:010444
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000394 xsd:string

[Term]
id: SCDO:1000395
name: Gene Regulatory Component
def: "A gene regulatory component is a gene component that exerts a regulatory function." []
xref: SIO:010085
is_a: SCDO:1000394 ! Gene Component
property_value: SCDO:0000340 SIO:010085
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000395 xsd:string

[Term]
id: SCDO:1000396
name: Gene Enhancer
def: "A gene enhancer is a short region of DNA that can be bound with proteins to enhance transcription levels of genes in a gene cluster." []
xref: SIO:010086
is_a: SCDO:1000395 ! Gene Regulatory Component
property_value: SCDO:0000340 SIO:010086
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000396 xsd:string

[Term]
id: SCDO:1000397
name: Gene Promoter
def: "A gene promoter is a region of DNA that initiates transcription of a particular gene." []
xref: SIO:010446
is_a: SCDO:1000395 ! Gene Regulatory Component
property_value: SCDO:0000340 SIO:010446
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000397 xsd:string

[Term]
id: SCDO:1000398
name: BCL11A Erythroid Enhancer
synonym: "Erythroid Specific Enhancer of Bcl11A" EXACT []
is_a: SCDO:1000396 ! Gene Enhancer
property_value: http://purl.org/dc/elements/1.1/source https://ash.confex.com/ash/2015/webprogramscheduler/Paper83338.html
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120587/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000401
name: Data Descriptor
def: "A characteristic that further describes the nature of data." []
is_a: SCDO:0006339 ! Research
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000402
name: Journal Article
def: "The predominant publication type for articles and other items indexed for NLM databases." []
xref: MESH:D016428
is_a: SCDO:0300003 ! Publication Formats
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016428
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000402 xsd:string

[Term]
id: SCDO:1000406
name: Data Sharing Descriptor
def: "A characteristic or directive that further describes the nature of data sharing." []
is_a: SCDO:0006339 ! Research
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000408
name: Data Use Requirements
def: "Requirements indicate additional conditions set for use of data." []
xref: DUO:0000017
is_a: SCDO:0006339 ! Research
property_value: SCDO:0000303 "Suggest update to description in DUO" xsd:string
property_value: SCDO:0000340 DUO:0000017
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000421
name: Participant Feedback Policy
def: "The standard method of providing feedback to study participants regarding their information (data, biological samples, genetic material) that has been shared." []
synonym: "Policy for Feedback to Participant" EXACT []
synonym: "Policy for Returning Results" EXACT []
synonym: "Policy for Returning Results to Participant" EXACT []
is_a: SCDO:1000422 ! Basic Element of a Consent Form
is_a: SCDO:1000424 ! Study Policy
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000422
name: Basic Element of a Consent Form
def: "An element or information entity that is required to be provided in consent forms." []
is_a: SCDO:0007597 ! Descriptor of Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000423
name: Participant Withdrawal Policy
def: "The policy regarding participants' right to withdraw their participation in a study." []
is_a: SCDO:1000422 ! Basic Element of a Consent Form
is_a: SCDO:1000424 ! Study Policy
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000424
name: Study Policy
def: "A course or principle of action adopted or proposed by a study." []
is_a: SCDO:0300005 ! Research Characteristics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000425
name: Study Focus Statement
def: "A statement of what the key investigational purpose of the study is." []
is_a: SCDO:1000422 ! Basic Element of a Consent Form
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000426
name: Communicable Disease - Report by Law Statement
def: "A statement about how the researcher is obligated by law to report if the participant is found to have a communicable disease." []
is_a: SCDO:1000422 ! Basic Element of a Consent Form
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000429
name: Medical Ethics
def: "The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families." []
xref: MESH:D004992
is_a: SCDO:0006706 ! Bioethics
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D004992
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000429 xsd:string

[Term]
id: SCDO:1000430
name: Ethics Related Concept
def: "Concepts related to ethics, excluding types of ethics." []
is_a: SCDO:0006339 ! Research
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000431
name: Intestinal Fatty-Acid Binding Protein
def: "A protein expressed in enterocytes of the small intestine and released into the systemic circulation when there is intestinal damage. This protein plays a role in binding to saturated long-chain fatty acids with a high affinity and to unsaturated long-chain fatty acids with less affinity." []
synonym: "FABPI" EXACT []
synonym: "Fatty Acid-Binding Protein, Intestinal" EXACT []
synonym: "I-FABP" EXACT []
synonym: "iFABP" EXACT []
synonym: "Intestinal-Type Fatty Acid-Binding Protein" EXACT []
xref: NCIT:C29616
is_a: NCIT:C26548 ! Gene Product
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/31146745
property_value: SCDO:0000303 "Suggest update to description in NCIT" xsd:string
property_value: SCDO:0000340 http://bioportal.bioontology.org/ontologies/NCIT?p=classes&conceptid=http%3A%2F%2Fncicb.nci.nih.gov%2Fxml%2Fowl%2FEVS%2FThesaurus.owl%23C29616
property_value: SCDO:0000340 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543649/
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000432
name: Serum iFABP Level
def: "The level of intestinal fatty-acid binding protein in the systemic circulation (serum)." []
comment: Measured in ng/ml
synonym: "Serum Intestinal Fatty-Acid Binding Protein Level" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543649/
property_value: SCDO:0000486 "Used to provide the evidence for intestinal injury due to VOC affecting the splanchnic vasculature." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000433
name: Intestinal Injury
def: "Damage inflicted on the intestine." []
synonym: "Intestinal Damage" EXACT []
is_a: HP:0025031 ! Abnormality of the Digestive System
is_a: NCIT:C3671 ! Injury
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/31146745
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000436
name: Hypoxia-Reperfusion Injury
def: "Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (reperfusion), including swelling; hemorrhage; necrosis; and damage from free radicals. The most common instance is myocardial reperfusion injury." []
synonym: "Hypoxia-Reoxygenation Injury" EXACT []
synonym: "Hypoxia/Reperfusion Injury" EXACT []
synonym: "IRI" EXACT []
synonym: "Ischaemia Reperfusion Injury" EXACT []
synonym: "Ischemia Reperfusion Injury" EXACT []
synonym: "Reoxygenation Injury" EXACT []
xref: EFO:0002687
is_a: NCIT:C3671 ! Injury
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543649/
property_value: SCDO:0000340 EFO:0002687
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000436 xsd:string

[Term]
id: SCDO:1000439
name: Elevated Serum iFABP Level
def: "An increased circulating blood concentration of the intestinal fatty-acid binding protein." []
comment: Significantly high serum iFABP levels is evidence of intestinal injury.
is_a: HP:0010876 ! Abnormal Circulating Protein Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543649/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000444
name: Serum L-Selectin Level
def: "The level of L-selectin in the systemic circulation (serum)." []
synonym: "Serum CD62L Level" EXACT []
synonym: "Soluble CD62L" EXACT []
is_a: CMO:0000023 ! Blood Chemistry Measurement
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000445
name: Aged Neutrophil Count
def: "The number of aged neutrophils in a specified volume of blood, usually 1 cubic millimeter." []
synonym: "Activated Neutrophil Count" EXACT []
is_a: CMO:0000030 ! Blood Neutrophil Count
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543649/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000448
name: Adjunct Analgesic Agent
def: "A medication that is typically used for indications other than pain control but provides control of pain in some painful diseases." []
synonym: "Adjuvant Analgesic Agent" EXACT []
is_a: SCDO:0001133 ! Symptomatic Therapeutics
property_value: http://purl.org/dc/elements/1.1/source Analgesic:adjuvant
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000449
name: Low-Dose Ketamine Infusion
def: "An infusion of ketamine at a low dose (up to 5 µg/kg/min)." []
comment: Low-dose ketamine infusion may be considered as an adjunct analgesic agent in patients with vaso-occlusive episodes who report continued severe pain despite high-dose opioid therapy, particularly those experiencing opioid-induced adverse effects.
is_a: SCDO:1000448 ! Adjunct Analgesic Agent
property_value: http://purl.org/dc/elements/1.1/source https://www.ncbi.nlm.nih.gov/pubmed/29791238
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000452
name: Cancer Pain
def: "Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during neoplasm growth, tissue invasion, and metastasis." []
synonym: "Cancer-Related Pain" EXACT []
synonym: "Pains, Neoplasm-Related" EXACT []
xref: MESH:D000072716
is_a: SCDO:0000851 ! Pain
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D000072716
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000452 xsd:string

[Term]
id: SCDO:1000455
name: Calculated Current Age (Years)
def: "The current age of a patient, calculated using the current date and the patient's date of birth and provided in years." []
synonym: "Calculated Current Age in Years" EXACT []
is_a: SCDO:1000527 ! Calculated Current Age
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000457
name: Temporal Consent Concept
def: "A type of consent that includes an aspect of timing (i.e. an indication of when consent was acquired)." []
is_a: NCIT:C25460 ! Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into ICO below \"Informed Consent\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000458
name: Prospective Consent
def: "Consent given prior to enrollment." []
is_a: SCDO:1000457 ! Temporal Consent Concept
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000459
name: Deferred Consent
def: "Consent that is taken later after enrollment into study especially in emergency situations." []
is_a: SCDO:1000457 ! Temporal Consent Concept
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Victoria Nembaware)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000460
name: Prospective Informed Consent
def: "Informed consent given prior to enrollment." []
is_a: SCDO:0007087 ! Informed Consent
is_a: SCDO:1000458 ! Prospective Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Victoria Nembaware)" xsd:string
property_value: SCDO:0000303 "Request inclusion into ICO below \"Informed Consent\"." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000461
name: Waived Consent
def: "Consent obtained at a population level through public/community engagement where individual consenting is not feasible. This is normally done for low risk studies and/or in case of emergencies." []
is_a: NCIT:C25460 ! Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Victoria Nembaware)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000462
name: Research Ethics Committee Decision
def: "A decision made by a research ethics committee." []
is_a: SCDO:1000430 ! Ethics Related Concept
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000463
name: Approval of Ethics
def: "When a research ethics committee approves a study's application for approval of their proposed research." []
is_a: SCDO:1000462 ! Research Ethics Committee Decision
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000464
name: Disapproval of Ethics
def: "When a research ethics committee declines a study's application for approval of their proposed research." []
is_a: SCDO:1000462 ! Research Ethics Committee Decision
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000465
name: Mode of Providing Consent
def: "A method in which a patient or their legal representative provides consent." []
is_a: SCDO:0007597 ! Descriptor of Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000466
name: Written Consent
def: "When the participant or a legal representative or family member provides consent by filling out and/or signing a written form." []
is_a: SCDO:1000465 ! Mode of Providing Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000467
name: Verbal Consent
def: "When the participant communicates consent orally rather than by filling out and signing a written form. Normally a witness is present when verbal consent is given." []
is_a: SCDO:1000465 ! Mode of Providing Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO" xsd:string
property_value: SCDO:0000303 "Request inclusion into the Informed Consent Ontology." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000470
name: SickleInAfrica Participant Number
def: "A unique identifier assigned to a study participant's data when it is registered in the SickleInAfrica data registry." []
is_a: NCIT:C69256 ! Subject Unique Identifier
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000471
name: Country of Data Collection
def: "The name of the country where the sample or data was collected." []
xref: FLU:0000831
is_a: SCDO:1000401 ! Data Descriptor
property_value: SCDO:0000340 FLU:0000831
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000472
name: Data Standards
def: "The rules by which data are described and recorded." []
is_a: SCDO:0001000 ! SCDO
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000340 https://www.usgs.gov/products/data-and-tools/data-management/data-standards
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: SCDO:1000474
name: Clinical or Research Assessment Data Element
def: "A data element used to capture or facilitate the capture of data in a clinical or research assessment." []
is_a: SCDO:1000472 ! Data Standards
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000475
name: Clinical or Research Assessment Question Type
def: "A type of question pertaining to a clinical or research assessment data element." []
is_a: SCDO:1000472 ! Data Standards
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000477
name: deprecated Field Type
is_a: SCDO:0000359 ! deprecated terms
is_obsolete: true

[Term]
id: SCDO:1000479
name: deprecated Calculation Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000480
name: deprecated  Checkbox Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000481
name: deprecated Descriptive Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000482
name: deprecated Dropdown Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000483
name: deprecated Dropdown Multiple Choice Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000484
name: deprecated Dropdown Single Choice Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000485
name: deprecated File Upload Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000486
name: deprecated Radio Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000487
name: deprecated Text Box Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000488
name: deprecated Notes Box Field Type
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000489
name: deprecated Slider - Visual Analog Scale
is_a: SCDO:1000477 ! deprecated Field Type
is_obsolete: true

[Term]
id: SCDO:1000490
name: Consent Status
def: "The situation, with regard to obtaining consent from a respondent, at a particular stage during a process." []
is_a: SCDO:0007597 ! Descriptor of Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000492
name: Close-Ended Question
def: "A question that provides the respondent with specific answer options to choose from." []
is_a: SCDO:1000475 ! Clinical or Research Assessment Question Type
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000493
name: Open-Ended Question
def: "A question that allows the respondent to give their own answer instead of selecting an answer from answer options." []
is_a: SCDO:1000475 ! Clinical or Research Assessment Question Type
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000494
name: Dichotomous Question
def: "A close-ended question that provides two possible answers." []
is_a: SCDO:1000492 ! Close-Ended Question
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000340 dichotomous:question
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000495
name: Multiple Choice Multiple Selection Question
def: "A close-ended question that provides multiple answers for respondents to select from and allows for the selection of multiple options." []
is_a: SCDO:1000492 ! Close-Ended Question
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000496
name: Multiple Choice Single Selection Question
def: "A close-ended question that provides multiple answers for respondents to select from but allows for the selection of only one option." []
is_a: SCDO:1000492 ! Close-Ended Question
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000497
name: True-False Question
def: "A dichotomous question that has answer options \"true\" and \"false\"." []
is_a: SCDO:1000494 ! Dichotomous Question
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000498
name: Yes-No Question
def: "A dichotomous question that has answer options \"yes\" and \"no\"." []
is_a: SCDO:1000494 ! Dichotomous Question
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000501
name: Open-Ended Question - Restricted
def: "A open ended question that restricts the nature of the text answer that can be provided by the respondent." []
is_a: SCDO:1000493 ! Open-Ended Question
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000502
name: Open-Ended Question - Free Text
def: "A open ended question that allows the respondent to respond in free text, without any restrictions on the nature of the text answer provided." []
is_a: SCDO:1000493 ! Open-Ended Question
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000508
name: SickleInAfrica Data Element
def: "A data element in a SickleInAfrica data capture instrument." []
synonym: "SickleInAfrica DE" EXACT []
is_a: SCDO:1000474 ! Clinical or Research Assessment Data Element
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000509
name: SickleInAfrica Core Data Element
def: "A data element in the SickleInAfrica core data capture instrument." []
synonym: "SickleInAfrica Core DE" EXACT []
is_a: SCDO:1000508 ! SickleInAfrica Data Element
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000510
name: SickleInAfrica CDE - Urinary Albumin Concentration Question
def: "The Sickle in Africa core data element that collects the concentration of albumin in the respondent's urine." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0001209 ! collects Urine Albumin Concentration
relationship: SCDO:1000771 NCIT:C64572 ! has answer standard unit microgram per millilitre
property_value: SCDO:1000518 "Urinary albumin concentration" xsd:string
property_value: SCDO:1000519 "urinary_microalbumin_conc" xsd:string
property_value: SCDO:1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "µg/mL; PX141501" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000512
name: SickleInAfrica CDE - Informed Consent Obtained Question
def: "The Sickle in Africa core data element that records whether the respondent has consented as necessary." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000526 OPMI:0000025 ! has answer option Do Not Know
relationship: SCDO:1000526 OPMI:0000027 ! has answer option Refused
relationship: SCDO:1000528 SCDO:1000513 ! collects Informed Consent Obtained
property_value: SCDO:1000517 "1, Yes\n2, No\n-7, Refused\n-9, Don't Know" xsd:string
property_value: SCDO:1000518 "Has the patient consented?" xsd:string
property_value: SCDO:1000519 "consent_obtained" xsd:string
property_value: SCDO:1000735 "Consent" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000749 "radio" xsd:string

[Term]
id: SCDO:1000513
name: Informed Consent Obtained
def: "An indication of whether informed consent was obtained from the respondent and/or their proxy." []
is_a: SCDO:1000490 ! Consent Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000514
name: Study Enrollment Consent
def: "Voluntary authorization given by a respondent and/or their proxy to be enrolled into a study as a research subject." []
is_a: SCDO:0007087 ! Informed Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps the ICO." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000515
name: Specimen Storage Consent
def: "Voluntary authorization given by a study respondent and/or their proxy to have their specimen(s) stored." []
is_a: SCDO:0007087 ! Informed Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps the ICO." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000516
name: Genetic Material Storage Consent
def: "Voluntary authorization given by a study paticipant to have their genetic material stored." []
is_a: SCDO:0007087 ! Informed Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "Request inclusion into relevant ontology, perhaps the ICO." xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000520
name: SickleInAfrica CDE - Type of Informed Consent Obtained Question
def: "The Sickle in Africa core data element that records the type(s) of informed consent obtained from the participant." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000495 ! is question type Multiple Choice Multiple Selection Question
relationship: SCDO:1000526 ICO:0000179 ! has answer option Broad Consent
relationship: SCDO:1000526 SCDO:1000514 ! has answer option Study Enrollment Consent
relationship: SCDO:1000526 SCDO:1000515 ! has answer option Specimen Storage Consent
relationship: SCDO:1000526 SCDO:1000516 ! has answer option Genetic Material Storage Consent
relationship: SCDO:1000528 SCDO:1000521 ! collects Type of Informed Consent Obtained
property_value: SCDO:1000517 "1, Study Enrollment Consent\n2, Specimen Storage Consent\n3, Genetic Material Storage Consent\n4, Broad Consent" xsd:string
property_value: SCDO:1000518 "Type(s) of informed consent obtained" xsd:string
property_value: SCDO:1000519 "consent_type" xsd:string
property_value: SCDO:1000735 "Consent" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000749 "checkbox" xsd:string

[Term]
id: SCDO:1000521
name: Type of Informed Consent Obtained
def: "An indication of the type of informed consent that was obtained from the respondent and/or their proxies." []
is_a: SCDO:1000490 ! Consent Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000522
name: Temporal Observable of Consent
def: "Time-related information that can be observed and is related to consent." []
is_a: SCDO:0007597 ! Descriptor of Consent
is_a: SCDO:1000537 ! Temporal Observable
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000527
name: Calculated Current Age
def: "The current age of a patient, calculated using the current date and the patient's date of birth." []
is_a: SCDO:0000304 ! Current Age
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000532
name: SickleInAfrica CDE - Date of Signing Consent Question
def: "The Sickle in Africa core data element that records the date on which the respondent signed the consent form for the relevant study." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 ICO:0000036 ! collects Date of Signing Consent
property_value: SCDO:1000518 "Date subject signed consent (dd/mm/yyyy)" xsd:string
property_value: SCDO:1000519 "consent_date" xsd:string
property_value: SCDO:1000735 "Consent" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000741 "date_dmy" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000533
name: SickleInAfrica CDE - Consented By Question
def: "The Sickle in Africa core data element that records the name of the person who managed the process of consenting the respondent." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000536 ! collects Consented By
property_value: SCDO:1000518 "Consented by:" xsd:string
property_value: SCDO:1000519 "consented_by" xsd:string
property_value: SCDO:1000735 "Consent" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000534
name: Blood Transfusion Since Last Visit
def: "An indication of whether the respondent has had a blood transfusion since their last hospital visit. This is any transfusion before enrolment if it is the patient's first hospital visit." []
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000535
name: Consent Form Uploaded
def: "An indication of whether the consent form used for obtaining informed consent from the respondent has been uploaded to the relevant electronic system." []
is_a: SCDO:1000490 ! Consent Status
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000536
name: Consented By
def: "The name of the person who conducted consenting of the respondent." []
is_a: SCDO:0007597 ! Descriptor of Consent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000537
name: Temporal Observable
def: "Time-related information that can be observed." []
is_a: SCDO:0001000 ! SCDO
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source http://purl.bioontology.org/ontology/SNOMEDCT/364713004
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000538
name: Diagnosis Temporal Observable
def: "Time-related information that can be observed and is related to a diagnosis." []
is_a: SCDO:1000537 ! Temporal Observable
is_a: SCDO:1000553 ! Diagnosis Descriptor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000539
name: SickleInAfrica CDE - Visit Date Question
def: "The Sickle in Africa core data element that records the visit date, in the format dd/mm/yyyy." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 NCIT:C83031 ! collects Visit Date
property_value: SCDO:1000518 "Visit date (dd/mm/yyyy)" xsd:string
property_value: SCDO:1000519 "date_today" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "date_dmy" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000542
name: SickleInAfrica CDE - Site Participant Number Question
def: "The Sickle in Africa core data element that records the site-specific unique identifier that was assigned to the study participant by the data collectors at the data collection site." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000730 ! collects Site Participant Number
property_value: SCDO:1000518 "Site participant number" xsd:string
property_value: SCDO:1000519 "participant_number" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000737 "Site-specific ID eg. GH20181234 for Ghana, NG20184321 for Nigeria or TZ20180001 for Tanzania" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000543
name: SickleInAfrica CDE - Date of Birth Question
def: "The Sickle in Africa core data element that records the respondent's date of birth in the format dd/mm/yyyy." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 NCIT:C68615 ! collects Birth Date
property_value: SCDO:1000518 "Date of birth (dd/mm/yyyy)" xsd:string
property_value: SCDO:1000519 "date_of_birth" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "9" xsd:integer
property_value: SCDO:1000741 "date_dmy" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000545
name: Calculated Current Age (Months)
def: "The current age of a patient, calculated using the current date and the patient's date of birth and provided in months." []
synonym: "Calculated Current Age in Months" EXACT []
is_a: SCDO:1000527 ! Calculated Current Age
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000546
name: Self-Reported Current Age (Years)
def: "The length of time that a person has lived since their birth up until the current day, as reported in years by the respondent." []
synonym: "Self-Reported Age in Years" EXACT []
synonym: "Self-Reported Current Age in Years" EXACT []
is_a: SCDO:0000304 ! Current Age
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000547
name: SickleInAfrica CDE - Self-Reported Age Question
def: "The Sickle in Africa core data element that records the respondent's age, as reported by the respondent in years." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000546 ! collects Self-Reported Current Age (Years)
property_value: SCDO:1000518 "Self-reported age (in years)" xsd:string
property_value: SCDO:1000519 "age_on_day_of_visit" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000737 "Age on day of visit" xsd:string
property_value: SCDO:1000739 "11" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000743 "0" xsd:integer
property_value: SCDO:1000744 "125" xsd:integer
property_value: SCDO:1000748 "RH" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000548
name: SickleInAfrica CDE - Current Marital Status Question
def: "The Sickle in Africa core data element that records the respondent's current marital status." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 NCIT:C156541 ! has answer option Separated
relationship: SCDO:1000526 NCIT:C51773 ! has answer option Married
relationship: SCDO:1000526 NCIT:C51774 ! has answer option Never Been Married
relationship: SCDO:1000526 NCIT:C51775 ! has answer option Widowed
relationship: SCDO:1000526 NCIT:C51776 ! has answer option Divorced
relationship: SCDO:1000528 SCDO:0000307 ! collects Current Marital Status
property_value: SCDO:1000517 "1, Married\n2, Widowed\n3, Divorced\n4, Separated\n5, Never been married/Annulled" xsd:string
property_value: SCDO:1000518 "Current marital status" xsd:string
property_value: SCDO:1000519 "marital_status" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "15" xsd:integer
property_value: SCDO:1000749 "radio" xsd:string

[Term]
id: SCDO:1000549
name: SickleInAfrica CDE - Date of Transfusion Question
def: "The Sickle in Africa core data element that records the date on which the respondent last received a blood transfusion." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000566 ! collects Date of Blood Transfusion
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000518 "Date of blood transfusion" xsd:string
property_value: SCDO:1000519 "transfusion_date" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "8" xsd:integer
property_value: SCDO:1000741 "date_dmy" xsd:string
property_value: SCDO:1000742 "[blood_transfusion] = \"Yes\"" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000550
name: SickleInAfrica CDE - SCD Other Test Question
def: "The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent, in the case where the type of test was not listed as an answer option in a  previous data element." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000577 ! collects Type of SCD Test
property_value: SCDO:1000518 "If other test, please specify:" xsd:string
property_value: SCDO:1000519 "other_test" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000739 "6" xsd:integer
property_value: SCDO:1000742 "[type_of_test] = '6'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000551
name: SickleInAfrica CDE - Sex Question
def: "The Sickle in Africa core data element that records the respondent's sex." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 GSSO:000109 ! has answer option Intersex
relationship: SCDO:1000526 NCIT:C16576 ! has answer option Female
relationship: SCDO:1000526 NCIT:C20197 ! has answer option Male
relationship: SCDO:1000526 OPMI:0000027 ! has answer option Refused
relationship: SCDO:1000528 NCIT:C28421 ! collects Sex
property_value: SCDO:1000517 "1, Male\n2, Female\n3, Intersex\n-7, Refused" xsd:string
property_value: SCDO:1000518 "Respondent's sex" xsd:string
property_value: SCDO:1000519 "respondent_sex" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "14" xsd:integer
property_value: SCDO:1000749 "radio" xsd:string

[Term]
id: SCDO:1000552
name: SickleInAfrica CDE - Date of Diagnosis Known Question
def: "The Sickle in Africa core data element that records whether the respondent knows the date of their SCD diagnosis." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:1000555 ! collects Date of SCD Diagnosis Known
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Is date of SCD diagnosis known?" xsd:string
property_value: SCDO:1000519 "diagnosis_date_known" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000553
name: Diagnosis Descriptor
def: "Information or a description that further describes a diagnosis." []
is_a: SCDO:0000379 ! Diagnostics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000554
name: Date of Diagnosis Known
def: "An indication of whether the date of the respondent's diagnosis of a disease is known by the respondent or the respondent's guardian." []
is_a: SCDO:1000538 ! Diagnosis Temporal Observable
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000555
name: Date of SCD Diagnosis Known
def: "An indication of whether the date of the respondent's SCD diagnosis is known by the respondent or the respondent's guardian." []
is_a: SCDO:1000554 ! Date of Diagnosis Known
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000556
name: SickleInAfrica CDE - Date of Diagnosis Question
def: "The Sickle in Africa core data element that records the respondent's date of diagnosis in the format dd/mm/yyyy." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000558 ! collects Date of SCD Diagnosis
property_value: SCDO:1000518 "Date of SCD diagnosis (dd/mm/yyyy)" xsd:string
property_value: SCDO:1000519 "exact_diagnosis_date" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000741 "date_dmy" xsd:string
property_value: SCDO:1000742 "[diagnosis_date_known] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000558
name: Date of SCD Diagnosis
def: "The date on which a diagnosis of sickle cell disease was made." []
is_a: NCIT:C164339 ! Date of Diagnosis
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000566
name: Date of Blood Transfusion
def: "The date on which a patient received a blood transfusion." []
is_a: SCDO:1000537 ! Temporal Observable
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000568
name: Year of SCD Diagnosis
def: "The year in which a sickle cell disease diagnosis was made." []
is_a: NCIT:C168823 ! Year of Diagnosis
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000569
name: Month of Diagnosis
def: "The month when a diagnosis was assigned to an individual's condition." []
is_a: SCDO:1000538 ! Diagnosis Temporal Observable
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000570
name: Month of SCD Diagnosis
def: "The month when a sickle cell disease diagnosis was made." []
is_a: SCDO:1000569 ! Month of Diagnosis
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000571
name: SickleInAfrica CDE - Month of Diagnosis Question
def: "The Sickle in Africa core data element that records the month of the year in which the respondent was diagnosed with SCD." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
property_value: SCDO:1000517 "-9, Don't know\n1, 1\n2, 2\n3, 3\n4, 4\n5, 5\n6, 6\n7, 7\n8, 8\n9, 9\n10, 10\n11, 11\n12, 12" xsd:string
property_value: SCDO:1000518 "Month of SCD diagnosis" xsd:string
property_value: SCDO:1000519 "month_of_diagnosis" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000742 "[diagnosis_date_known] = '0'" xsd:string
property_value: SCDO:1000749 "dropdown" xsd:string

[Term]
id: SCDO:1000572
name: Diagnosis
def: "A diagnosis is the result of a medical investigation to identify a disorder from its signs and symptoms." []
xref: SIO:001331
is_a: NCIT:C18772 ! Personal Medical History
property_value: SCDO:0000340 SIO:001331
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000572 xsd:string

[Term]
id: SCDO:1000573
name: SickleInAfrica CDE - SCD Test Result Question
def: "The Sickle in Africa core data element that records the respondent's SCD test result." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 NCIT:C131682 ! has answer option Sickle Cell Disease-SS
relationship: SCDO:1000526 NCIT:C95539 ! has answer option Sickle Beta Thalassemia
relationship: SCDO:1000526 OPMI:0000028 ! has answer option Other
relationship: SCDO:1000526 SCDO:0001055 ! has answer option Sickle Cell Trait
relationship: SCDO:1000526 SCDO:0001059 ! has answer option Sickle Cell Disease-SC
relationship: SCDO:1000528 SCDO:1000574 ! collects SCD Test Result
property_value: SCDO:1000517 "1, SS\n2, SBThal\n3, SC\n4, AS\n5, Other" xsd:string
property_value: SCDO:1000518 "SCD test result" xsd:string
property_value: SCDO:1000519 "scd_test_result" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000737 "SS = Sickle Cell Disease-SS | SBThal = Sickle Beta Thalassemia | SC = Sickle Cell Disease-SC | AS = Sickle Cell Trait" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000748 "RH" xsd:string
property_value: SCDO:1000749 "dropdown" xsd:string

[Term]
id: SCDO:1000574
name: SCD Test Result
def: "The result of a medical investigation to identify the type of sickle cell disease that a person has." []
is_a: CMO:0000508 ! Hemoglobin Measurement
is_a: SCDO:1000572 ! Diagnosis
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000575
name: SickleInAfrica CDE - Type of SCD Test Question
def: "The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 CHMO:0001009 ! has answer option High-Performance Liquid Chromatography
relationship: SCDO:1000526 OPMI:0000028 ! has answer option Other
relationship: SCDO:1000526 SCDO:0000666 ! has answer option Isoelectric Focusing
relationship: SCDO:1000526 SCDO:1000580 ! has answer option Hemoglobin Electrophoresis
relationship: SCDO:1000526 SCDO:1000669 ! has answer option Sickle SCAN Rapid Test
relationship: SCDO:1000526 SCDO:1000768 ! has answer option Acide
relationship: SCDO:1000526 SCDO:1000769 ! has answer option Basique
relationship: SCDO:1000528 SCDO:1000577 ! collects Type of SCD Test
property_value: SCDO:1000517 "1, HPLC\n2, HBE\n3, IEF\n4, Basique\n5, Acide\n6, Sickle SCAN rapid test\n7, Other" xsd:string
property_value: SCDO:1000518 "Type of test?" xsd:string
property_value: SCDO:1000519 "type_of_test" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000737 "HPLC =  High-Performance Liquid Chromatography| HBE = Hemoglobin Electrophoresis | IEF = Isoelectric Focusing| Basique = Basique SCD Test | Acide = Acide SCD Test" xsd:string
property_value: SCDO:1000739 "5" xsd:integer
property_value: SCDO:1000749 "dropdown" xsd:string

[Term]
id: SCDO:1000576
name: Diagnostic Measurement Descriptor
def: "A piece of information that further describes a diagnostic measurement." []
is_a: SCDO:0000379 ! Diagnostics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000577
name: Type of SCD Test
def: "The type of test that was used to obtain a sickle cell disease diagnosis." []
is_a: SCDO:1000576 ! Diagnostic Measurement Descriptor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000578
name: SickleInAfrica CDE - SCD Test Other Result Question
def: "The Sickle in Africa core data element that records the respondent's SCD test result, in the case where the specific result was not listed as an answer option in a previous data element." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000574 ! collects SCD Test Result
property_value: SCDO:1000518 "If other SCD test result, please specify:" xsd:string
property_value: SCDO:1000519 "other_scd_test_result" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000579
name: SickleInAfrica CDE - Blood Group Question
def: "The Sickle in Africa core data element that records the respondent's ABO Blood Group." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 SCDO:1000582 ! has answer option Blood Type A Positive
relationship: SCDO:1000526 SCDO:1000583 ! has answer option Blood Type A Negative
relationship: SCDO:1000526 SCDO:1000584 ! has answer option Blood Type B Positive
relationship: SCDO:1000526 SCDO:1000585 ! has answer option Blood Type B Negative
relationship: SCDO:1000526 SCDO:1000586 ! has answer option Blood Type O Positive
relationship: SCDO:1000526 SCDO:1000587 ! has answer option Blood Type O Negative
relationship: SCDO:1000526 SCDO:1000588 ! has answer option Blood Type AB Positive
relationship: SCDO:1000526 SCDO:1000589 ! has answer option Blood Type AB Negative
relationship: SCDO:1000528 HP:0032224 ! collects ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000517 "1, A+\n2, A-\n3, B+\n4, B-\n5, O+\n6, O-\n7, AB+\n8, AB-" xsd:string
property_value: SCDO:1000518 "ABO blood group" xsd:string
property_value: SCDO:1000519 "abo_blood_group" xsd:string
property_value: SCDO:1000735 "SCD Diagnosis Details" xsd:string
property_value: SCDO:1000739 "7" xsd:integer
property_value: SCDO:1000749 "dropdown" xsd:string

[Term]
id: SCDO:1000580
name: Hemoglobin Electrophoresis
def: "A blood test that uses the principles of gel electrophoresis to separate out the various types of hemoglobin in order to determine the level of different types of hemoglobin in the blood." []
synonym: "Electrophoresis - hemoglobin" EXACT []
synonym: "Haemoglobin Electrophoresis" EXACT []
synonym: "Hb electrophoresis" EXACT []
synonym: "HBE" EXACT []
synonym: "Hemoglobinopathy - electrophoresis" EXACT []
synonym: "Hgb electrophoresis" EXACT []
synonym: "Sickle cell - electrophoresis" EXACT []
synonym: "Thalassemia Screening" EXACT []
synonym: "Thallasemia - electrophoresis" EXACT []
is_a: SCDO:0000424 ! Electrophoresis
is_a: SCDO:0000522 ! Hemoglobin Variant Test
is_a: SCDO:1000577 ! Type of SCD Test
property_value: http://purl.org/dc/elements/1.1/source Hemoglobin:electrophoresis
property_value: http://purl.org/dc/elements/1.1/source https://medlineplus.gov/ency/article/003639.htm
property_value: SCDO:0000303 "Placed as sub-class here according to position in the \"Read Codes, Clinical Terms Version 3 (CTV3)\" Ontology" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000582
name: Blood Type A Positive
def: "A blood type containing type A red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." []
synonym: "A+" EXACT []
synonym: "Blood group A Rh(D) positive" EXACT []
synonym: "Type A blood, Rh positive" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Kambe Banda)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000583
name: Blood Type A Negative
def: "A blood type containing type A red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor." []
def: "SCDO (Kambe Banda)" []
synonym: "A-" EXACT []
synonym: "Blood group A Rh(D) negative" EXACT []
synonym: "Type A blood, Rh negative" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000584
name: Blood Type B Positive
def: "A blood type containing type B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." []
synonym: "B+" EXACT []
synonym: "Blood group B Rh(D) positive" EXACT []
synonym: "Type B blood, Rh positive" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Kambe Banda)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000585
name: Blood Type B Negative
def: "A blood type containing type B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor." []
synonym: "B-" EXACT []
synonym: "Blood group B Rh(D) negative" EXACT []
synonym: "Type B blood, Rh negative" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Kambe Banda)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000586
name: Blood Type O Positive
def: "A blood type containing no surface markers on red blood cells, with the presence of a protein called rhesus (Rh) factor." []
synonym: "Blood group O Rh(D) positive" EXACT []
synonym: "O+" EXACT []
synonym: "Type O blood, Rh positive" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Kambe Banda)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000587
name: Blood Type O Negative
def: "A blood type containing no surface markers on red blood cells, with the absence of a protein called rhesus (Rh) factor." []
synonym: "Blood group O Rh(D) negative" EXACT []
synonym: "O-" EXACT []
synonym: "Type O blood, Rh negative" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Kambe Banda)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000588
name: Blood Type AB Positive
def: "A blood type containing both type A and B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor." []
synonym: "AB+" EXACT []
synonym: "Blood group AB Rh(D) positive" EXACT []
synonym: "Type AB blood, Rh positive" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Kambe Banda)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000589
name: Blood Type AB Negative
def: "A blood type containing both type A and B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor" []
synonym: "AB-" EXACT []
synonym: "Blood group AB Rh(D) negative" EXACT []
synonym: "Type AB blood, Rh negative" EXACT []
is_a: HP:0032224 ! ABO Blood Group
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Kambe Banda)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000590
name: SCD Management Details
def: "Information about how a patient's SCD is being managed." []
is_a: NCIT:C19332 ! Personal Attribute
is_a: SCDO:0001152 ! Therapeutics
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000591
name: SickleInAfrica CDE - Hydroxyurea Use Question
def: "The Sickle in Africa core data element that records the respondent's hydroxyurea use status (i.e. an indication of whether the respondent is using hydroxyurea)." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:1000592 ! collects Hydroxyurea Use Status
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Using hydroxyurea" xsd:string
property_value: SCDO:1000519 "using_hydroxyurea" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000748 "RH" xsd:string
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000592
name: Hydroxyurea Use Status
def: "An indication of whether the respondent is using hydroxyurea." []
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000593
name: SickleInAfrica CDE - Hydroxyurea Initiation Date Question
def: "The Sickle in Africa core data element that records the date on which the respondent started hydroxyurea therapy, in the format dd/mm/yyyy." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000594 ! collects Date of Hydroxyurea Therapy Initiation
property_value: SCDO:1000518 "Date of initiation of hydroxyurea therapy (dd/mm/yyyy)" xsd:string
property_value: SCDO:1000519 "date_of_initiation_of_hydr" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000741 "date_dmy" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000594
name: Date of Hydroxyurea Therapy Initiation
def: "The date on which hydroxyurea therapy was initiated." []
is_a: SCDO:1000537 ! Temporal Observable
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000595
name: SickleInAfrica CDE - Penicillin V Use Question
def: "The Sickle in Africa core data element that records whether the respondent is using penicillin V as a prophylaxis against bacterial infections." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 NCIT:C48660 ! has answer option NA
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:1000596 ! collects Penicillin V Prophylaxis Use Status
property_value: SCDO:1000517 "1, Yes\n2, No\n-6, NA" xsd:string
property_value: SCDO:1000518 "Using penicillin V (prophylaxis)" xsd:string
property_value: SCDO:1000519 "penicillin_v_prophylaxis" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000748 "RH" xsd:string
property_value: SCDO:1000749 "radio" xsd:string

[Term]
id: SCDO:1000596
name: Penicillin V Prophylaxis Use Status
def: "An indication of whether the respondent is using penicillin V prophylaxis." []
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000597
name: SickleInAfrica CDE - Folic Acid Use Question
def: "The Sickle in Africa core data element that records the respondent's folic acid use status (i.e. an indication of whether the respondent is using folic acid)." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:1000598 ! collects Folic Acid Use Status
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Using folic acid" xsd:string
property_value: SCDO:1000519 "folic_acid" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "5" xsd:integer
property_value: SCDO:1000748 "RH" xsd:string
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000598
name: Folic Acid Use Status
def: "An indication of whether the respondent is using folic acid." []
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000599
name: Malaria Prophylaxis Status
def: "An indication of whether the respondent is using malaria prophylaxis." []
is_a: SCDO:1000318 ! Diagnostic Instrument Measurement
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000600
name: SickleInAfrica CDE - Malaria Prophylaxis Question
def: "The Sickle in Africa core data element that records whether the respondent is using malaria chemoprophylaxis (drugs that prevent malaria)." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 NCIT:C48660 ! has answer option NA
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:1000599 ! collects Malaria Prophylaxis Status
property_value: SCDO:1000517 "1, Yes\n2, No\n-6, NA" xsd:string
property_value: SCDO:1000518 "Using malaria chemoprophylaxis" xsd:string
property_value: SCDO:1000519 "antimalaria_prophylaxis" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000749 "radio" xsd:string

[Term]
id: SCDO:1000601
name: SickleInAfrica CDE - Pneumococcal Vaccination Question
def: "The Sickle in Africa core data element that records whether the respondent's pneumococcal vaccination is up to date." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:1000602 ! collects Pneumococcal Vaccination Status
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Pneumococcal vaccination up to date" xsd:string
property_value: SCDO:1000519 "pneumococcal_vacc_uptodate" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "6" xsd:integer
property_value: SCDO:1000748 "RH" xsd:string
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000602
name: Pneumococcal Vaccination Status
def: "An indication of whether the respondent is up to date with their pneumococcal vaccinations." []
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000604
name: Management Details Added By
def: "The person who recorded the information about how a patient's condition is being managed." []
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000605
name: Blood Urea Analysis
def: "Any assay which measures the amount, level or concentration of urea in whole blood." []
xref: MMO:0000272
is_a: SCDO:0000133 ! Blood Test
relationship: SCDO:1000194 EUPATH:0021227 ! measures Blood Urea Concentration
property_value: SCDO:0000340 MMO:0000272
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000605 xsd:string

[Term]
id: SCDO:1000606
name: Management Details Add Date
def: "The date on which the respondent's management details were added/recorded." []
is_a: SCDO:1000537 ! Temporal Observable
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000607
name: SickleInAfrica CDE - Red Blood Cell Count Question
def: "The Sickle in Africa core data element that collects the red blood cell count in the respondent's blood, as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000025 ! collects Red Blood Cell Count
relationship: SCDO:1000771 NCIT:C67251 ! has answer standard unit million cells per microliter
property_value: SCDO:1000518 "Red blood cell count (RBC)" xsd:string
property_value: SCDO:1000519 "cbc_redbloodcount" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "million cells/µL" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000611
name: SickleInAfrica CDE - White Blood Cell Count Question
def: "The Sickle in Africa core data element that collects the white blood cell count in the respondent's blood, as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000027 ! collects White Blood Cell Count
relationship: SCDO:1000771 NCIT:C67244 ! has answer standard unit thousand cells per microliter
property_value: SCDO:1000518 "White blood cell count (WBC)" xsd:string
property_value: SCDO:1000519 "cbc_whitebloodcount" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "1000 cells/µL" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000612
name: Abnormal Leukocyte Morphology
def: "Any structural abnormality of leukocytes (nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue)." []
xref: HP:0001881
is_a: HP:0001871 ! Abnormality of Blood and Blood-Forming Tissues
is_a: HP:0002715 ! Abnormality of the Immune System
property_value: SCDO:0000303 "Suggest the HPO update their definition. Theirs currently is \"An abnormality of leukocytes.\"" xsd:string
property_value: SCDO:0000340 HP:0001881
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000615
name: SickleInAfrica CDE - Platelet Count Question
def: "The Sickle in Africa core data element that collects the platelet count in the respondent's blood, as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000029 ! collects Platelet Count
relationship: SCDO:1000771 NCIT:C67244 ! has answer standard unit thousand cells per microliter
property_value: SCDO:1000518 "Platelet count" xsd:string
property_value: SCDO:1000519 "cbc_platelet_count" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "1000 cells/µL" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000619
name: SickleInAfrica CDE - Hemoglobin - CBC Question
def: "The Sickle in Africa core data element that collects the concentration of hemoglobin in the respondent's blood, as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000506 ! collects Hemoglobin Concentration
relationship: SCDO:1000771 NCIT:C64783 ! has answer standard unit g/dL
property_value: SCDO:1000518 "Hemoglobin" xsd:string
property_value: SCDO:1000519 "cbc_hemoglobin" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "g/dL" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000621
name: SickleInAfrica CDE - Mean Cell Volume Question
def: "The Sickle in Africa core data element that collects the respondent's mean cell volume (MCV), as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000038 ! collects Mean Corpuscular Volume
relationship: SCDO:1000771 UO:0000104 ! has answer standard unit fL
property_value: SCDO:1000518 "Mean cell volume (MCV)" xsd:string
property_value: SCDO:1000519 "cbc_mean_cell_volume" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "fL" xsd:string
property_value: SCDO:1000739 "5" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000627
name: SickleInAfrica CDE - Mean Cell Hemoglobin Question
def: "The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin  (MCH), as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000290 ! collects Mean Corpuscular Hemoglobin Level
relationship: SCDO:1000771 UO:0000025 ! has answer standard unit pg
property_value: SCDO:1000518 "Mean cell hemoglobin (MCH)" xsd:string
property_value: SCDO:1000519 "cbc_mean_cell_hemoglobin" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "pg" xsd:string
property_value: SCDO:1000739 "6" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000630
name: SickleInAfrica CDE - Mean Cell Hemoglobin Concentration Question
def: "The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin concentration (MCHC), as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000291 ! collects Mean Corpuscular Hemoglobin Concentration
relationship: SCDO:1000771 NCIT:C64783 ! has answer standard unit g/dL
property_value: SCDO:1000518 "Mean cell hemoglobin concentration (MCHC)" xsd:string
property_value: SCDO:1000519 "cbc_mchc" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "g/dL" xsd:string
property_value: SCDO:1000739 "7" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000637
name: SickleInAfrica CDE - Red Cell Distribution Width Question
def: "The Sickle in Africa core data element that collects the respondent's red cell distribution width, as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000638 ! collects Red Blood Cell Distribution Width
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Red cell distribution width (RDW)" xsd:string
property_value: SCDO:1000519 "cbc_redcelldistributionwidth" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "8" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000638
name: Red Blood Cell Distribution Width
def: "Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. Usually red blood cells are a standard size of about 6-8 μm in diameter. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.[1] If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia. It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause." []
synonym: "RCDW" EXACT []
synonym: "RDW" EXACT []
synonym: "Red Cell Distribution Width" EXACT []
xref: EFO:0009188
is_a: CMO:0001356 ! Red Blood Cell Measurement
relationship: SCDO:1000190 CMO:0000364 ! obtained via diagnostic tool Complete Blood Count
relationship: SCDO:1000772 MP:0010067 ! has possible finding Increased Red Blood Cell Distribution Width
relationship: SCDO:1000772 MP:0010068 ! has possible finding Decreased Red Blood Cell Distribution Width
relationship: SCDO:1000772 SCDO:1000828 ! has possible finding Normal Red Blood Cell Distribution Width
property_value: SCDO:0000340 EFO:0009188
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000638 xsd:string

[Term]
id: SCDO:1000645
name: SickleInAfrica CDE - Serum Creatinine Concentration Question
def: "The Sickle in Africa core data element that collects the level of serum creatinine in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000057 ! collects Serum Creatinine Level
relationship: SCDO:1000771 NCIT:C67015 ! has answer standard unit mg/dL
property_value: SCDO:1000518 "Serum creatinine concentration" xsd:string
property_value: SCDO:1000519 "serum_creatinine_conc" xsd:string
property_value: SCDO:1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "mg/dL; PX141401" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000649
name: Elevated Serum Creatinine
def: "An abnormally increased amount of creatinine in the blood." []
synonym: "Elevated Creatinine" EXACT []
synonym: "High Blood Creatinine Level" EXACT []
synonym: "Increased Creatinine" EXACT []
synonym: "Increased Serum Creatinine" EXACT []
xref: HP:0003259
is_a: HP:0002157 ! Azotaemia
is_a: HP:0012100 ! Abnormal Circulating Creatinine Level
property_value: SCDO:0000303 "Suggest update to description in HPO (include the word \"abnormally\")" xsd:string
property_value: SCDO:0000340 HP:0003259
property_value: SCDO:1000288 "Suggest update to description" xsd:string

[Term]
id: SCDO:1000650
name: SickleInAfrica CDE - Urinary Creatinine Concentration Question
def: "The Sickle in Africa core data element that collects the concentration of creatinine in the respondent's urine." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0001213 ! collects Urine Creatinine Concentration
relationship: SCDO:1000771 NCIT:C67015 ! has answer standard unit mg/dL
property_value: SCDO:1000518 "Urinary creatinine concentration" xsd:string
property_value: SCDO:1000519 "urinary_creatinine_conc" xsd:string
property_value: SCDO:1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "mg/dL; PX141601" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000657
name: SickleInAfrica CDE - Alanine Aminotransferase Level Question
def: "The Sickle in Africa core data element that collects the level of alanine aminotransferase in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0000035 ! collects Alanine Aminotransferase Level
relationship: SCDO:1000771 NCIT:C67376 ! has answer standard unit IU/L
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000518 "Alanine aminotransferase level" xsd:string
property_value: SCDO:1000519 "results_of_alanine_at_assay" xsd:string
property_value: SCDO:1000735 "Liver Function Assay (PhenX protocol PX190801 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "IU/L" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000660
name: SickleInAfrica CDE - Aspartate Aminotransferase Level Question
def: "The Sickle in Africa core data element that collects the level of aspartate aminotransferase in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0000080 ! collects Aspartate Aminotransferase Level
relationship: SCDO:1000771 NCIT:C67376 ! has answer standard unit IU/L
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000518 "Aspartate aminotransferase level" xsd:string
property_value: SCDO:1000519 "results_of_aspartate_at_assay" xsd:string
property_value: SCDO:1000735 "Liver Function Assay (PhenX protocol PX190801 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "IU/L" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000662
name: SickleInAfrica CDE - Alkaline Phosphatase Level Question
def: "The Sickle in Africa core data element that collects the level of alkaline phosphatase in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 VT:0000202 ! collects Alkaline Phosphatase Level
relationship: SCDO:1000771 NCIT:C67376 ! has answer standard unit IU/L
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000518 "Alkaline phosphatase level" xsd:string
property_value: SCDO:1000519 "results_of_alkaline_phosphatase_assay" xsd:string
property_value: SCDO:1000735 "Liver Function Assay (PhenX protocol PX190801 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "IU/L" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000663
name: Alkaline Phosphatase Blood Test
def: "A quantitative measurement of alkaline phosphatase present in a blood sample." []
synonym: "Alkaline Phosphatase Test" EXACT []
is_a: NCIT:C74954 ! Liver Function Test
is_a: SCDO:0000133 ! Blood Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000669
name: Sickle SCAN Rapid Test
def: "A multiplexed qualitative point-of-care immunoassay used for the rapid diagnosis of sickle cell disorders. The test is made up of three indicators which detect the presence of hemoglobins A, S, and C, allowing the user to rapidly distinguish between normal, carrier, and sickle cell samples." []
is_a: SCDO:0000522 ! Hemoglobin Variant Test
is_a: SCDO:1000577 ! Type of SCD Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: http://purl.org/dc/elements/1.1/source https://www.sicklescan.com/
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000673
name: Current Partner Status
def: "An indication of a person's current status in terms of living with a person as though married (in a romantic relationship and living together but not married)." []
is_a: NCIT:C16495 ! Demographic Factor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000679
name: Past Partner Status
def: "An indication of whether a person has previously lived with someone as though married (in a romantic relationship and lived together but were not married)." []
is_a: NCIT:C16495 ! Demographic Factor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000680
name: SickleInAfrica CDE - Total Bilirubin Concentration Question
def: "The Sickle in Africa core data element that collects the level of billirubin in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000376 ! collects Total Serum Bilirubin Level
relationship: SCDO:1000771 NCIT:C67015 ! has answer standard unit mg/dL
property_value: SCDO:1000518 "Total billirubin concentration" xsd:string
property_value: SCDO:1000519 "billirubin_total_billirubin_conc" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Bilirubin Level (PhenX protocol PX0810901 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "mg/dL" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000682
name: SickleInAfrica CDE - Lactate Dehydrogenase Level Question
def: "The Sickle in Africa core data element that collects the level of lactate dehydrogenase in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0000682 ! collects Lactate Dehydrogenase Level
relationship: SCDO:1000771 NCIT:C67376 ! has answer standard unit IU/L
property_value: SCDO:1000518 "Lactate dehydrogenase level" xsd:string
property_value: SCDO:1000519 "lactate_dehydrogenase_conc" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Lactate Dehydrogenase Level (PhenX protocol PX0811001 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "IU/L" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000684
name: Reduced Lactate Dehydrogenase Level
def: "A decreased or reduced level of the enzyme lactate dehydrogenase in serum." []
synonym: "Decreased Lactate Dehydrogenase Level" EXACT []
xref: HP:0045041
is_a: HP:0045040 ! Abnormal Lactate Dehydrogenase Level
property_value: SCDO:0000303 "The current label in HPO is \"Reduced lactate dehydrogenase B level\". Seems the \"B\" in the label and the comment that refers to the B subunit should be removed." xsd:string
property_value: SCDO:0000340 HP:0045041
property_value: SCDO:1000288 "Suggest update to label" xsd:string

[Term]
id: SCDO:1000685
name: SickleInAfrica CDE - Reticulocyte Count Question
def: "The Sickle in Africa core data element that collects the reticulocyte count in the respondent's blood, as measured by a complete blood count." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0001004 ! collects Reticulocyte Count
relationship: SCDO:1000771 NCIT:C67244 ! has answer standard unit thousand cells per microliter
property_value: SCDO:1000518 "Number of reticulocytes" xsd:string
property_value: SCDO:1000519 "reticulocyte_amount" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Reticulocyte Count (PhenX protocol PX0810601 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "1000 cells/µL" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000686
name: Reticulocyte Count Assay
def: "A test used to measure the reticulocyte count (number of reticulocytes in a given volume of blood)." []
synonym: "Retic Count" EXACT []
synonym: "Reticulocyte Count Test" EXACT []
is_a: SCDO:0000133 ! Blood Test
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810601
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000687
name: SickleInAfrica CDE - Hb Assay Results Recorded Question
def: "The Sickle in Africa core data element that records the hemoglobins for which assay results were recorded." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000495 ! is question type Multiple Choice Multiple Selection Question
relationship: SCDO:1000526 SCDO:0000513 ! has answer option Hemoglobin C
relationship: SCDO:1000526 SCDO:0000514 ! has answer option Hemoglobin S
relationship: SCDO:1000526 SCDO:0000528 ! has answer option Hemoglobin D-Punjab
relationship: SCDO:1000526 SCDO:0004139 ! has answer option Adult Hemoglobin
relationship: SCDO:1000526 SCDO:0005446 ! has answer option Fetal Hemoglobin
relationship: SCDO:1000526 SCDO:1000009 ! has answer option Hemoglobin E
relationship: SCDO:1000526 SCDO:1000016 ! has answer option Hemoglobin O-Arab
relationship: SCDO:1000526 SCDO:1000364 ! has answer option Hemoglobin A2
relationship: SCDO:1000526 SCDO:1000689 ! has answer option Hemoglobin G-Philadelphia
relationship: SCDO:1000528 SCDO:1000688 ! collects Hemoglobin Assay Results Recorded
property_value: SCDO:1000517 "1, Hb A\n2, Hb  F\n3, Hb  S\n4, Hb  C\n5, Hb  E\n6, Hb A2\n7, Hb  D-Punjab\n8, Hb  G-Philadelphia\n9, Hb  O-Arab" xsd:string
property_value: SCDO:1000518 "For which hemoglobins were assay results recorded?" xsd:string
property_value: SCDO:1000519 "scd_hemoglobin_assay_results" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "Select all relevant options" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000748 "LH" xsd:string
property_value: SCDO:1000749 "checkbox" xsd:string

[Term]
id: SCDO:1000688
name: Hemoglobin Assay Results Recorded
def: "The hemoglobins for which assay results were recorded." []
is_a: SCDO:1000576 ! Diagnostic Measurement Descriptor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000689
name: Hemoglobin G-Philadelphia
def: "Hemoglobin G Philadelphia (HbG Phil) is a structural variant of the hemoglobin molecule that involves the alpha chain rather than the beta chain. It has a frequency of about 1 in 5,000 African Americans, but has been reported in other ethnic groups in the Mediterranean region as well, HbG Phil itself has no clinical consequences. The only finding of clinical interest is the mild microcytosis. While this molecule has no clinical consequences, the presence helps to distinguish HbG from HbD that shares its electrophoretic migration on HPLC and gel electrophoresis and which does have consequences when it occurs with sickle trait." []
synonym: "Hb G-Phil" EXACT []
synonym: "Hb G-Philadelphia" EXACT []
synonym: "HbG Phil" EXACT []
synonym: "Hemoglobin G Philadelphia" EXACT []
xref: LNC:LP16433-2
is_a: SCDO:0006921 ! Hemoglobin Variant
property_value: SCDO:0000340 https://loinc.org/80655-4/
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000689 xsd:string

[Term]
id: SCDO:1000690
name: Hemoglobin A Level
def: "The amount of hemoglobin A present in a specified volume of blood." []
synonym: "Haemoglobin A Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 SCDO:0000976 ! has possible finding Reduced Hemoglobin A
relationship: SCDO:1000772 SCDO:1000241 ! has possible finding Absent Hemoglobin A
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Negligible" xsd:string

[Term]
id: SCDO:1000691
name: SickleInAfrica CDE - Hemoglobin A Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000690 ! collects Hemoglobin A Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb A if measured." xsd:string
property_value: SCDO:1000519 "hba2" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(1)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000692
name: Hemoglobin S Level
def: "The amount of hemoglobin S present in a specified volume of blood." []
synonym: "Haemoglobin S Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 SCDO:1000784 ! has possible finding Absent Hemoglobin S
relationship: SCDO:1000772 SCDO:1000844 ! has possible finding Hemoglobin S Present
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000693
name: SickleInAfrica CDE - Hemoglobin S Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin S." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000692 ! collects Hemoglobin S Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb S if measured." xsd:string
property_value: SCDO:1000519 "hbs" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(3)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000694
name: SickleInAfrica CDE - Hemoglobin C Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin C." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000695 ! collects Hemoglobin C Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb C if measured." xsd:string
property_value: SCDO:1000519 "hbc" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "5" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(4)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000695
name: Hemoglobin C Level
def: "The amount of hemoglobin C present in a specified volume of blood." []
synonym: "Haemoglobin C Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 SCDO:1000036 ! has possible finding Hemoglobin C Present
relationship: SCDO:1000772 SCDO:1000806 ! has possible finding Absent Hemoglobin C
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000696
name: SickleInAfrica CDE - Hemoglobin E Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin E." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000697 ! collects Hemoglobin E Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb E if measured." xsd:string
property_value: SCDO:1000519 "hbe" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "6" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(5)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000697
name: Hemoglobin E Level
def: "The amount of hemoglobin E present in a specified volume of blood." []
synonym: "Haemoglobin E Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 SCDO:1000179 ! has possible finding Absent Hemoglobin E
relationship: SCDO:1000772 SCDO:1000181 ! has possible finding Hemoglobin E Present
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000698
name: Hemoglobin A2 Level
def: "The amount of hemoglobin A2 present in a specified volume of blood." []
synonym: "Haemoglobin A2 Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 HP:0045048 ! has possible finding Increased Hemoglobin A2
relationship: SCDO:1000772 SCDO:1000187 ! has possible finding Normal Hemoglobin A2 Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000699
name: SickleInAfrica CDE - Hemoglobin A2 Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A2." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000698 ! collects Hemoglobin A2 Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb A2 if measured." xsd:string
property_value: SCDO:1000519 "hb_a2" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "7" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(6)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000700
name: SickleInAfrica CDE - Hemoglobin D-Punjab Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin D-Punjab." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000701 ! collects Hemoglobin D-Punjab Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb D-Punjab if measured." xsd:string
property_value: SCDO:1000519 "hb_dpunjab" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "8" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(7)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000701
name: Hemoglobin D-Punjab Level
def: "The amount of hemoglobin D-Punjab present in a specified volume of blood." []
synonym: "Haemoglobin D-Punjab Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 SCDO:1000289 ! has possible finding Hemoglobin D-Punjab Present
relationship: SCDO:1000772 SCDO:1000816 ! has possible finding Absent Hemoglobin D-Punjab
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000702
name: SickleInAfrica CDE - Hemoglobin G-Philadelphia Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin G-Philadelphia." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000703 ! collects Hemoglobin G-Philadelphia Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb G-Philadelphia if measured." xsd:string
property_value: SCDO:1000519 "hb_gphilidelphia" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "9" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(8)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000703
name: Hemoglobin G-Philadelphia Level
def: "The amount of hemoglobin G-Philadelphia present in a specified volume of blood." []
synonym: "Haemoglobin G-Philadelphia Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 SCDO:1000290 ! has possible finding Hemoglobin G-Philadelphia Present
relationship: SCDO:1000772 SCDO:1000817 ! has possible finding Absent Hemoglobin G-Philadelphia
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000704
name: SickleInAfrica CDE - Hemoglobin O-Arab Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin O-Arab." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000705 ! collects Hemoglobin O-Arab Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb O-Arab if measured." xsd:string
property_value: SCDO:1000519 "hb_o_arab" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "10" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(9)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000705
name: Hemoglobin O-Arab Level
def: "The amount of hemoglobin O-Arab present in a specified volume of blood." []
synonym: "Haemoglobin O-Arab Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 SCDO:1000291 ! has possible finding Hemoglobin O-Arab Present
relationship: SCDO:1000772 SCDO:1000818 ! has possible finding Absent Hemoglobin O-Arab
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000706
name: SickleInAfrica CDE - Hemoglobin F Level Question
def: "The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin F." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000707 ! collects Hemoglobin F Level
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Record the levels of Hb F if measured." xsd:string
property_value: SCDO:1000519 "hbf_percent" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[scd_hemoglobin_assay_results(2)] = '1'" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000707
name: Hemoglobin F Level
def: "The amount of hemoglobin F present in a specified volume of blood." []
synonym: "Haemoglobin F Level" EXACT []
is_a: SCDO:0000546 ! Hemoglobin Profile
relationship: SCDO:1000005 SCDO:0000094 ! modified by BCL11A
relationship: SCDO:1000005 SCDO:0000117 ! modified by Beta-Globin Haplotype
relationship: SCDO:1000005 SCDO:0000580 ! modified by Hydroxyurea
relationship: SCDO:1000005 SCDO:0000810 ! modified by Non-Globin Gene
relationship: SCDO:1000005 SCDO:1000063 ! modified by HBB, 106-KB DEL
relationship: SCDO:1000015 SCDO:0000251 ! modifies Clinical Phenotype of Beta Thalassemia
relationship: SCDO:1000015 SCDO:0000895 ! modifies Phenotype of Sickle Cell Disease
relationship: SCDO:1000190 CHMO:0001009 ! obtained via diagnostic tool High-Performance Liquid Chromatography
relationship: SCDO:1000190 SCDO:0000182 ! obtained via diagnostic tool Capillary Electrophoresis
relationship: SCDO:1000190 SCDO:0000547 ! obtained via diagnostic tool Hemoglobin Profile Assay
relationship: SCDO:1000772 HP:0011904 ! has possible finding Increased Hemoglobin F
relationship: SCDO:1000772 SCDO:1000292 ! has possible finding Normal Hemoglobin F Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000708
name: Sex of Spouse
def: "The sex of the respondent's spouse, as provided by the respondent." []
is_a: NCIT:C16495 ! Demographic Factor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000709
name: Sex of Partner
def: "The sex of the respondent's partner (where the partner is not a spouse), as provided by the respondent." []
is_a: NCIT:C16495 ! Demographic Factor
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000711
name: SickleInAfrica CDE - Body Temperature Question
def: "The Sickle in Africa core data element that collects the respondent's body temperature." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000015 ! collects Body Temperature
relationship: SCDO:1000771 NCIT:C42559 ! has answer standard unit Degree Celsius
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000518 "Patient's body temperature" xsd:string
property_value: SCDO:1000519 "body_temperature" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000737 "degrees Celsius" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000743 "13" xsd:integer
property_value: SCDO:1000744 "46" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000714
name: SickleInAfrica CDE - Respiratory Rate Question
def: "The Sickle in Africa core data element that collects the respondent's respiratory rate." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0000993 ! collects Respiratory Rate
relationship: SCDO:1000771 NCIT:C49674 ! has answer standard unit Breaths per Minute
property_value: SCDO:1000518 "Patient's respiratory rate" xsd:string
property_value: SCDO:1000519 "respiratory_rate" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000737 "breaths per minute" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000717
name: SickleInAfrica CDE - Partial Pressure CO2 Question
def: "The Sickle in Africa core data element that collects the respondent's partial pressure of carbon dioxide in their arterial blood, as measured by an arterial blood gas test." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000283 ! collects Partial Pressure of Carbon Dioxide
relationship: SCDO:1000771 UO:0000272 ! has answer standard unit mmHg
property_value: SCDO:1000518 "Partial pressure of carbon dioxide (PaCO2)" xsd:string
property_value: SCDO:1000519 "partial_pressure_co2" xsd:string
property_value: SCDO:1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "mmHg" xsd:string
property_value: SCDO:1000739 "1" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000722
name: SickleInAfrica CDE - Partial Pressure O2 Question
def: "The Sickle in Africa core data element that collects the respondent's partial pressure of oxygen their arterial blood, as measured by an arterial blood gas test." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000723 ! collects Partial Pressure of Oxygen
relationship: SCDO:1000771 UO:0000272 ! has answer standard unit mmHg
property_value: SCDO:1000518 "Partial pressure of oxygen (PaO2)" xsd:string
property_value: SCDO:1000519 "partial_pressure_of_oxygen" xsd:string
property_value: SCDO:1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "mmHg" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000723
name: Partial Pressure of Oxygen
def: "The pressure exerted by oxygen dissolved in the blood, indicating how well oxygen is able to move from the airspace of the lungs into the blood." []
synonym: "Oxygen Tension" EXACT []
synonym: "PaO2" EXACT []
synonym: "Partial Pressure of Blood Oxygen" EXACT []
synonym: "Partial Pressure of Blood Oxygen (Po2)" EXACT []
synonym: "Partial Pressure of Oxygen (PaO2)" EXACT []
synonym: "Po2" EXACT []
xref: CMO:0000381
is_a: CMO:0000225 ! Arterial Blood Gas Measurement
relationship: SCDO:1000190 SCDO:0000071 ! obtained via diagnostic tool Arterial Blood Gas Test
relationship: SCDO:1000772 SCDO:1000819 ! has possible finding Decreased Partial Pressure of Oxygen
relationship: SCDO:1000772 SCDO:1000838 ! has possible finding Normal Partial Pressure of Oxygen
property_value: SCDO:1000288 "Few but available definitions not adequate" xsd:string

[Term]
id: SCDO:1000724
name: SickleInAfrica CDE - Oxyhemoglobin Saturation Question
def: "The Sickle in Africa core data element that collects the respondent's arterial oxygen saturation (oxyhemoglobin saturation), as measured by an arterial blood gas test." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0000849 ! collects Arterial Oxygen Saturation
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Oxyhemoglobin saturation (HbO2)" xsd:string
property_value: SCDO:1000519 "oxyhemoglobin_saturation" xsd:string
property_value: SCDO:1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "3" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000725
name: SickleInAfrica CDE - Carboxyhemoglobin Question
def: "The Sickle in Africa core data element that collects the respondent's carboxyhemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000728 ! collects Carboxyhemoglobin to Total Hemoglobin Ratio
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000518 "Carboxyhemoglobin (COHb)" xsd:string
property_value: SCDO:1000519 "carboxyhemoglobin" xsd:string
property_value: SCDO:1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000726
name: SickleInAfrica CDE - Methemoglobin Question
def: "The Sickle in Africa core data element that collects the respondent's methemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000727 ! collects Methemoglobin to Total Hemoglobin Ratio
relationship: SCDO:1000771 UO:0000187 ! has answer standard unit Percent
property_value: SCDO:1000518 "Methemoglobin (MetHb)" xsd:string
property_value: SCDO:1000519 "methemoglobin" xsd:string
property_value: SCDO:1000735 "Arterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "%" xsd:string
property_value: SCDO:1000739 "5" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000727
name: Methemoglobin to Total Hemoglobin Ratio
def: "The ratio of methemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage." []
synonym: "HGBMHGB" EXACT []
synonym: "MetHb Saturation" EXACT []
synonym: "Methemoglobin Saturation" EXACT []
synonym: "Methemoglobin to Total Hemoglobin Ratio Measurement" EXACT []
synonym: "Methemoglobin/Total Hemoglobin" EXACT []
xref: EFO:0009226
is_a: CMO:0000508 ! Hemoglobin Measurement
relationship: SCDO:1000190 SCDO:0000071 ! obtained via diagnostic tool Arterial Blood Gas Test
relationship: SCDO:1000772 SCDO:1000729 ! has possible finding Increased Methemoglobin
relationship: SCDO:1000772 SCDO:1000815 ! has possible finding Normal Methemoglobin Level
property_value: SCDO:0000340 EFO:0009226
property_value: SCDO:1000288 "Used term from existing ontology but will suggest they update their label and description to ours." xsd:string

[Term]
id: SCDO:1000728
name: Carboxyhemoglobin to Total Hemoglobin Ratio
def: "The ratio of carboxyhemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage." []
synonym: "Carboxyhemoglobin Saturation" EXACT []
synonym: "Carboxyhemoglobin/Total Hemoglobin" EXACT []
synonym: "COHb Saturation" EXACT []
xref: EFO:0009203
is_a: CMO:0000508 ! Hemoglobin Measurement
relationship: SCDO:1000190 SCDO:0000071 ! obtained via diagnostic tool Arterial Blood Gas Test
relationship: SCDO:1000772 SCDO:1000807 ! has possible finding Increased Carboxyhemoglobin
relationship: SCDO:1000772 SCDO:1000814 ! has possible finding Normal Carboxyhemoglobin Level
property_value: SCDO:0000340 EFO:0009203
property_value: SCDO:1000288 "Used term from existing ontology but will suggest they update their label and description to ours." xsd:string

[Term]
id: SCDO:1000729
name: Increased Methemoglobin
def: "An elevated concentration in the blood of methemoglobin, which is the ferric (Fe(3+)) form of hemoglobin." []
comment: Injury or toxic agents can convert a larger proportion of hemoglobin to methemoglobin, which does not function reversibly as an oxygen carrier and thus less oxygen is made available to the tissues.
synonym: "Methemoglobin Increased" EXACT []
synonym: "Raised Methemoglobin" EXACT []
is_a: HP:0020063 ! Increased Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000730
name: Site Participant Number
def: "A site-specific unique identifier assigned to a study participant by the data collectors at the data collection site." []
is_a: NCIT:C69256 ! Subject Unique Identifier
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000731
name: SCD Passport Number
def: "A unique identifier provided on SCD passports." []
is_a: NCIT:C69256 ! Subject Unique Identifier
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000732
name: SickleInAfrica CDE - SickleInAfrica Participant Number
def: "The Sickle in Africa core data element that records the unique identifier that was assigned to the study participant's data when it was registered in the SickleInAfrica data registry." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000528 SCDO:1000470 ! collects SickleInAfrica Participant Number
property_value: SCDO:1000518 "SickleInAfrica Participant Number" xsd:string
property_value: SCDO:1000519 "record_id" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000734
name: SickleInAfrica CDE - Age In Months Calculation
def: "The Sickle in Africa core data element that calculates the respondent's age in months, using the visit date and birth date collected by other core data elements." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000528 SCDO:1000545 ! collects Calculated Current Age (Months)
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000518 "Calculated age (in months)" xsd:string
property_value: SCDO:1000519 "calc_age_on_day_of_visit" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000736 "datediff([date_today],[date_of_birth], \"M\",\"dmy\")" xsd:string
property_value: SCDO:1000737 "Age on day of visit" xsd:string
property_value: SCDO:1000739 "10" xsd:integer
property_value: SCDO:1000748 "RH" xsd:string
property_value: SCDO:1000749 "calc" xsd:string

[Term]
id: SCDO:1000738
name: SickleInAfrica Core Data Element Instrument
def: "A data capture instrument designed and applied by the Sickle In Africa Consortium." []
is_a: NCIT:C91105 ! Clinical or Research Assessment Questionnaire
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string
property_value: SCDO:1000740 "Consent\nDemographics\nSCD Diagnosis Details\nManagement Details\nLaboratory Results: Complete Blood Count (PhenX protocol PX220501 unless stated otherwise)\nKidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)\nLiver Function Assay (PhenX protocol PX190801 unless stated otherwise)\nLaboratory Results: Bilirubin Level (PhenX protocol PX0810901 unless stated otherwise)\nLaboratory Results: Lactate Dehydrogenase Level (PhenX protocol PX0811001 unless stated otherwise)\nLaboratory Results: Reticulocyte Count (PhenX protocol PX0810601 unless stated otherwise)\nLaboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)\nArterial blood gas - ABG (PhenX protocol PX090201 unless stated otherwise)" xsd:string

[Term]
id: SCDO:1000751
name: SickleInAfrica CDE - Total Hemoglobin Question
def: "The Sickle in Africa core data element that collects the total concentration of hemoglobin in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 CMO:0000506 ! collects Hemoglobin Concentration
relationship: SCDO:1000771 NCIT:C64783 ! has answer standard unit g/dL
property_value: SCDO:1000518 "Total hemoglobin (Hbtotal)" xsd:string
property_value: SCDO:1000519 "total_hemoglobin" xsd:string
property_value: SCDO:1000735 "Laboratory Results: Hemoglobin Characterisation (PhenX protocol PX0830301 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "g/dL" xsd:string
property_value: SCDO:1000739 "11" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000753
name: Body Temperature - Oral Measurement Assay
def: "An assay to determine the body temperature of an evaluant using an oral thermometer." []
synonym: "Oral Temperature Taking" EXACT []
is_a: OBI:0002140 ! Temperature Measurement Assay
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000340 https://www.phenxtoolkit.org/protocols/view/810102?origin=search
property_value: SCDO:0000479 "PhenX protocol: Body Temperature - Oral Thermometers #810102" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000754
name: Body Temperature - Tympanic Measurement Assay
def: "An assay to determine the body temperature of an evaluant using a tympanic (i.e. ear) thermometer." []
synonym: "Tympanic Temperature Taking" EXACT []
is_a: OBI:0002140 ! Temperature Measurement Assay
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000479 "PhenX protocol: Body Temperature - Tympanic Thermometers #810101" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000755
name: Oral Temperature
def: "The temperature of the oral cavity." []
synonym: "Oral Body Temperature" EXACT []
xref: VSO:0000025
is_a: CMO:0000015 ! Body Temperature
property_value: SCDO:0000340 VSO:0000025
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000755 xsd:string

[Term]
id: SCDO:1000756
name: Tympanic Temperature
def: "The temperature of the external acoustic tube." []
synonym: "Tympanic (ear) Temperature" EXACT []
synonym: "Tympanic Body Temperature" EXACT []
xref: VSO:0000045
is_a: CMO:0000015 ! Body Temperature
property_value: SCDO:0000340 VSO:0000045
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000756 xsd:string

[Term]
id: SCDO:1000757
name: Rectal Temperature
def: "The temperature of the lumen of the rectum." []
synonym: "Rectal Body Temperature" EXACT []
xref: VSO:0000033
is_a: CMO:0000015 ! Body Temperature
property_value: SCDO:0000340 VSO:0000033
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000757 xsd:string

[Term]
id: SCDO:1000758
name: Axillary Temperature
def: "The temperature of the axillary fossa." []
synonym: "Armpit Temperature" EXACT []
synonym: "Axillary (armpit) Temperature" EXACT []
xref: VSO:0000003
is_a: CMO:0000015 ! Body Temperature
property_value: SCDO:0000340 VSO:0000003
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000758 xsd:string

[Term]
id: SCDO:1000759
name: SickleInAfrica CDE - Type of Temperature Question
def: "The Sickle in Africa core data element that records the type of body temperature that was taken for the respondent." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 SCDO:1000755 ! has answer option Oral Temperature
relationship: SCDO:1000526 SCDO:1000756 ! has answer option Tympanic Temperature
relationship: SCDO:1000526 SCDO:1000757 ! has answer option Rectal Temperature
relationship: SCDO:1000526 SCDO:1000758 ! has answer option Axillary Temperature
relationship: SCDO:1000528 SCDO:1000763 ! collects Type of Body Temperature
property_value: SCDO:1000517 "1, Oral Temperature\n2, Tympanic (ear) Temperature\n3, Axillary (armpit) Temperature\n4, Rectal Temperature" xsd:string
property_value: SCDO:1000518 "Type of body temperature taken" xsd:string
property_value: SCDO:1000519 "type_of_temp" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000749 "dropdown" xsd:string

[Term]
id: SCDO:1000763
name: Type of Body Temperature
is_a: SCDO:1000576 ! Diagnostic Measurement Descriptor

[Term]
id: SCDO:1000766
name: Year 1900 - Current
def: "An answer to a question where the answer is a year between 1900 and the current year, selected from a provided list of years." []
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000767
name: Month 1 - 12
def: "An answer to a question where the answer is a month between 1 - 12, selected form a list of months." []
is_a: NCIT:C91106 ! Clinical or Research Assessment Answer
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000768
name: Acide
is_a: SCDO:1000577 ! Type of SCD Test
property_value: SCDO:0000303 "Waiting for description for this." xsd:string

[Term]
id: SCDO:1000769
name: Basique
def: "Waiting for description for this." []
is_a: SCDO:1000577 ! Type of SCD Test

[Term]
id: SCDO:1000774
name: D57.03 Hb-SS disease with cerebral vascular involvement
def: "-" []
synonym: "D57.03" EXACT []
synonym: "Hb-SS disease with cerebral vascular involvement" EXACT []
synonym: "Sickle cell anemia with cerebral vascular involvement" EXACT []
xref: ICD10CM:D57.03
is_a: SCDO:0000312 ! D57.0 Hb-SS disease with crisis
relationship: SCDO:1000785 NCIT:C131682 ! code requires phenotype Sickle Cell Disease-SS
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:1000037 ! code requires phenotype Abnormality of the Cerebral Vasculature
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.03
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000775
name: D57.09 Hb-SS disease with crisis with other specified complication
def: "-" []
synonym: "D57.09" EXACT []
synonym: "Hb-SS disease with crisis with other specified complication" EXACT []
synonym: "Sickle cell anemia with crisis with other specified complication" EXACT []
xref: ICD10CM:D57.09
is_a: SCDO:0000312 ! D57.0 Hb-SS disease with crisis
relationship: SCDO:1000785 NCIT:C131682 ! code requires phenotype Sickle Cell Disease-SS
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.09
property_value: SCDO:1000176 "yes" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000783
name: Normal Hemoglobin Concentration
def: "When there is no deviation from the normal concentration of hemoglobin in the blood." []
is_a: SCDO:0009613 ! Protein Phenotype
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000784
name: Absent Hemoglobin S
def: "A lack of production of hemoglobin S." []
synonym: "Absent Haemoglobin S" EXACT []
synonym: "Haemoglobin S Absent" EXACT []
synonym: "Hemoglobin S Absent" EXACT []
synonym: "Normal Haemoglobin S Level" EXACT []
synonym: "Normal Hemoglobin S Level" EXACT []
xref: MEDDRA:10055604
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000786
name: D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement
def: "-" []
synonym: "D57.213" EXACT []
synonym: "Sickle Cell Disease-SC with cerebral vascular involvement" EXACT []
synonym: "Sickle-cell/Hb-C disease with cerebral vascular involvement" EXACT []
xref: ICD10CM:D57.213
is_a: SCDO:0000318 ! D57.21 Sickle-cell/Hb-C disease with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
relationship: SCDO:1000785 SCDO:1000037 ! code requires phenotype Abnormality of the Cerebral Vasculature
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.213
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000787
name: D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication
def: "-" []
synonym: "D57.218" EXACT []
synonym: "Sickle Cell Disease-SC with crisis with other specified complication" EXACT []
synonym: "Sickle-cell/Hb-C disease with crisis with other specified complication" EXACT []
xref: ICD10CM:D57.218
is_a: SCDO:0000318 ! D57.21 Sickle-cell/Hb-C disease with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001059 ! code requires phenotype Sickle Cell Disease-SC
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.218
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000788
name: D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
def: "-" []
synonym: "D57.413" EXACT []
xref: ICD10CM:D57.413
is_a: SCDO:0000325 ! D57.41 Sickle-cell thalassemia, unspecified, with crisis
relationship: SCDO:1000785 NCIT:C95539 ! code requires phenotype Sickle Beta Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:1000037 ! code requires phenotype Abnormality of the Cerebral Vasculature
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.413
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000789
name: D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication
def: "-" []
synonym: "D57.418" EXACT []
synonym: "Sickle-cell thalassemia, unspecified, with crisis with other specified complication" EXACT []
xref: ICD10CM:D57.418
is_a: SCDO:0000325 ! D57.41 Sickle-cell thalassemia, unspecified, with crisis
relationship: SCDO:1000785 NCIT:C95539 ! code requires phenotype Sickle Beta Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.418
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000790
name: D57.42 Sickle-cell thalassemia beta zero without crisis
def: "-" []
synonym: "D57.42" EXACT []
synonym: "Sickle-cell thalassemia beta zero without crisis" EXACT []
xref: ICD10CM:D57.42
is_a: SCDO:0000323 ! D57.4 Sickle-cell thalassemia
relationship: SCDO:1000785 NCIT:C3833 ! code requires phenotype Asymptomatic
relationship: SCDO:1000785 NCIT:C98835 ! code requires phenotype Sickle Cell Disease-S Beta Zero Thalassemia
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.42
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000791
name: D57.43 Sickle-cell thalassemia beta zero with crisis
def: "-" []
synonym: "D57.43" EXACT []
synonym: "Sickle-cell thalassemia beta zero with crisis" EXACT []
xref: ICD10CM:D57.43
is_a: SCDO:0000323 ! D57.4 Sickle-cell thalassemia
relationship: SCDO:1000785 NCIT:C98835 ! code requires phenotype Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.43
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000792
name: D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome
def: "-" []
synonym: "D57.431" EXACT []
synonym: "Sickle-cell thalassemia beta zero with acute chest syndrome" EXACT []
xref: ICD10CM:D57.431
is_a: SCDO:1000791 ! D57.43 Sickle-cell thalassemia beta zero with crisis
relationship: SCDO:1000785 DOID:1584 ! code requires phenotype Acute Chest Syndrome
relationship: SCDO:1000785 NCIT:C98835 ! code requires phenotype Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.431
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000793
name: D57.432 Sickle-cell thalassemia beta zero with splenic sequestration
def: "-" []
synonym: "D57.432" EXACT []
synonym: "Sickle-cell thalassemia beta zero with splenic sequestration" EXACT []
xref: ICD10CM:D57.432
is_a: SCDO:1000791 ! D57.43 Sickle-cell thalassemia beta zero with crisis
relationship: SCDO:1000785 NCIT:C98835 ! code requires phenotype Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000785 SCDO:0007161 ! code requires phenotype Acute Splenic Sequestration Crisis
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.432
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000794
name: D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement
def: "-" []
synonym: "D57.433" EXACT []
synonym: "Sickle-cell thalassemia beta zero with cerebral vascular involvement" EXACT []
xref: ICD10CM:D57.433
is_a: SCDO:1000791 ! D57.43 Sickle-cell thalassemia beta zero with crisis
relationship: SCDO:1000785 NCIT:C98835 ! code requires phenotype Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:1000037 ! code requires phenotype Abnormality of the Cerebral Vasculature
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.433
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000795
name: D57.438 Sickle-cell thalassemia beta zero with crisis with other specified complication
def: "-" []
synonym: "D57.438" EXACT []
synonym: "Sickle-cell thalassemia beta zero with crisis with other specified complication" EXACT []
xref: ICD10CM:D57.438
is_a: SCDO:1000791 ! D57.43 Sickle-cell thalassemia beta zero with crisis
relationship: SCDO:1000785 NCIT:C98835 ! code requires phenotype Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.438
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000796
name: D57.439 Sickle-cell thalassemia beta zero with crisis, unspecified
def: "-" []
synonym: "D57.439" EXACT []
synonym: "Sickle-cell thalassemia beta zero with crisis, unspecified" EXACT []
xref: ICD10CM:D57.439
is_a: SCDO:1000791 ! D57.43 Sickle-cell thalassemia beta zero with crisis
relationship: SCDO:1000785 NCIT:C98835 ! code requires phenotype Sickle Cell Disease-S Beta Zero Thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.439
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000797
name: D57.44 Sickle-cell thalassemia beta plus without crisis
def: "-" []
synonym: "D57.44" EXACT []
synonym: "Sickle-cell thalassemia beta minus without crisis" EXACT []
synonym: "Sickle-cell thalassemia beta plus without crisis" EXACT []
xref: ICD10CM:D57.44
is_a: SCDO:0000323 ! D57.4 Sickle-cell thalassemia
relationship: SCDO:1000785 NCIT:C3833 ! code requires phenotype Asymptomatic
relationship: SCDO:1000785 SCDO:0001056 ! code requires phenotype Sickle Cell Disease-S Beta Minus Thalassemia
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.44
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000798
name: D57.45 Sickle-cell thalassemia beta plus with crisis
def: "-" []
synonym: "D57.45" EXACT []
synonym: "Sickle-cell thalassemia beta minus with crisis" EXACT []
synonym: "Sickle-cell thalassemia beta plus with crisis" EXACT []
xref: ICD10CM:D57.45
is_a: SCDO:0000323 ! D57.4 Sickle-cell thalassemia
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001056 ! code requires phenotype Sickle Cell Disease-S Beta Minus Thalassemia
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.45
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000799
name: D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome
def: "-" []
synonym: "D57.451" EXACT []
synonym: "Sickle-cell thalassemia beta minus with acute chest syndrome" EXACT []
synonym: "Sickle-cell thalassemia beta plus with acute chest syndrome" EXACT []
xref: ICD10CM:D57.451
is_a: SCDO:1000798 ! D57.45 Sickle-cell thalassemia beta plus with crisis
relationship: SCDO:1000785 DOID:1584 ! code requires phenotype Acute Chest Syndrome
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001056 ! code requires phenotype Sickle Cell Disease-S Beta Minus Thalassemia
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.451
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000800
name: D57.452 Sickle-cell thalassemia beta plus with splenic sequestration
def: "-" []
synonym: "D57.452" EXACT []
synonym: "Sickle-cell thalassemia beta minus with splenic sequestration" EXACT []
synonym: "Sickle-cell thalassemia beta plus with splenic sequestration" EXACT []
xref: ICD10CM:D57.452
is_a: SCDO:1000798 ! D57.45 Sickle-cell thalassemia beta plus with crisis
relationship: SCDO:1000785 SCDO:0001056 ! code requires phenotype Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1000785 SCDO:0007161 ! code requires phenotype Acute Splenic Sequestration Crisis
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.452
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000801
name: D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement
def: "-" []
synonym: "D57.453" EXACT []
synonym: "Sickle-cell thalassemia beta minus with cerebral vascular involvement" EXACT []
synonym: "Sickle-cell thalassemia beta plus with cerebral vascular involvement" EXACT []
xref: ICD10CM:D57.453
is_a: SCDO:1000798 ! D57.45 Sickle-cell thalassemia beta plus with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001056 ! code requires phenotype Sickle Cell Disease-S Beta Minus Thalassemia
relationship: SCDO:1000785 SCDO:1000037 ! code requires phenotype Abnormality of the Cerebral Vasculature
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.453
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000802
name: D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication
def: "-" []
synonym: "D57.458" EXACT []
synonym: "Sickle-cell thalassemia beta minus with crisis with other specified complication" EXACT []
synonym: "Sickle-cell thalassemia beta plus with crisis with other specified complication" EXACT []
xref: ICD10CM:D57.458
is_a: SCDO:1000798 ! D57.45 Sickle-cell thalassemia beta plus with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001056 ! code requires phenotype Sickle Cell Disease-S Beta Minus Thalassemia
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.458
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000803
name: D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified
def: "-" []
synonym: "D57.459" EXACT []
synonym: "Sickle-cell thalassemia beta minus with crisis, unspecified" EXACT []
synonym: "Sickle-cell thalassemia beta plus with crisis, unspecified" EXACT []
xref: ICD10CM:D57.459
is_a: SCDO:1000798 ! D57.45 Sickle-cell thalassemia beta plus with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:0001056 ! code requires phenotype Sickle Cell Disease-S Beta Minus Thalassemia
property_value: http://purl.org/dc/elements/1.1/source https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.459
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000804
name: D57.818 Other sickle-cell disorders with crisis with other specified complication
def: "-" []
synonym: "D57.818" EXACT []
xref: ICD10CM:D57.818
is_a: SCDO:0000331 ! D57.81 Other sickle-cell disorders with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.818
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000805
name: D57.813 Other sickle-cell disorders with cerebral vascular involvement
def: "-" []
synonym: "D57.813" EXACT []
xref: ICD10CM:D57.813
is_a: SCDO:0000331 ! D57.81 Other sickle-cell disorders with crisis
relationship: SCDO:1000785 SCDO:0001053 ! code requires phenotype Sickle Cell Painful Event
relationship: SCDO:1000785 SCDO:1000037 ! code requires phenotype Abnormality of the Cerebral Vasculature
property_value: http://purl.org/dc/elements/1.1/source http://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.813
property_value: SCDO:1000288 "Few but definitions not freely available" xsd:string

[Term]
id: SCDO:1000806
name: Absent Hemoglobin C
def: "A lack of production of hemoglobin C." []
synonym: "Absent Haemoglobin C" EXACT []
synonym: "Haemoglobin C Absent" EXACT []
synonym: "Hemoglobin C Absent" EXACT []
synonym: "Normal Haemoglobin C Level" EXACT []
synonym: "Normal Hemoglobin C Level" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000807
name: Increased Carboxyhemoglobin
def: "An elevated concentration in the blood of carboxyhemoglobin, which is the form of hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO)." []
synonym: "Carboxyhemoglobin Increased" EXACT []
synonym: "Raised Carboxyhemoglobin" EXACT []
is_a: HP:0020063 ! Increased Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000808
name: Decreased Arterial Oxygen Saturation
def: "An abnormal reduction in the amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity." []
synonym: "Arterial Oxygen Saturation Decreased" EXACT []
synonym: "Decreased Arterial HbO2" EXACT []
synonym: "Decreased Arterial Oxyhemoglobin Saturation" EXACT []
synonym: "Decreased Arterial SaO2" EXACT []
synonym: "Decreased Arterial Sats" EXACT []
synonym: "Decreased Oxygen Saturation of Arterial Blood" EXACT []
synonym: "Decreased Oxyhemoglobin/Total Hemoglobin" EXACT []
synonym: "Low Arterial Oxygen Saturation" EXACT []
is_a: MP:0002329 ! Abnormal Blood Gas Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000812
name: Normal Metabolism/Homeostasis Phenotype
def: "A phenotype of the body's metabolism or homeostasis that is not clinically abnormal." []
is_a: MP:0005376 ! Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000813
name: Normal Arterial Oxygen Saturation
def: "When the degree to which oxygen is bound to hemoglobin in arterial blood is in the normal range." []
synonym: "Normal Arterial Blood Oxygen Saturation" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000814
name: Normal Carboxyhemoglobin Level
def: "When the level of carboxyhemoglobin detected in a sample of blood falls in the normal range for carboxyhemoglobin." []
synonym: "Carboxyhemoglobin Normal" EXACT []
synonym: "Normal Carboxyhemoglobin Concentration" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000815
name: Normal Methemoglobin Level
def: "When the level of methemoglobin detected in a sample of blood falls in the normal range for methemoglobin." []
synonym: "MetHb Normal" EXACT []
synonym: "Normal MetHb Level" EXACT []
synonym: "Normal Methemoglobin Concentration" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000816
name: Absent Hemoglobin D-Punjab
def: "A lack of production of hemoglobin D-Punjab." []
synonym: "Absent Haemoglobin D-Punjab" EXACT []
synonym: "Haemoglobin D-Punjab Absent" EXACT []
synonym: "Hemoglobin D-Punjab Absent" EXACT []
synonym: "Normal Haemoglobin D-Punjab Level" EXACT []
synonym: "Normal Hemoglobin D-Punjab Level" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000817
name: Absent Hemoglobin G-Philadelphia
def: "A lack of production of hemoglobin G-Philadelphia." []
synonym: "Absent Haemoglobin G-Philadelphia" EXACT []
synonym: "Haemoglobin G-Philadelphia Absent" EXACT []
synonym: "Hemoglobin G-Philadelphia Absent" EXACT []
synonym: "Normal Haemoglobin G-Philadelphia Level" EXACT []
synonym: "Normal Hemoglobin G-Philadelphia Level" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000818
name: Absent Hemoglobin O-Arab
def: "A lack of production of hemoglobin O-Arab." []
synonym: "Absent Haemoglobin O-Arab" EXACT []
synonym: "Haemoglobin O-Arab Absent" EXACT []
synonym: "Hemoglobin O-Arab Absent" EXACT []
synonym: "Normal Haemoglobin O-Arab Level" EXACT []
synonym: "Normal Hemoglobin O-Arab Level" EXACT []
is_a: SCDO:1000783 ! Normal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000819
name: Decreased Partial Pressure of Oxygen
def: "An abnormal reduction in the pressure exerted by oxygen dissolved in the blood." []
synonym: "Arterial Oxygen Partial Pressure Decreased" EXACT []
synonym: "Decreased Oxygen Tension" EXACT []
synonym: "Decreased PaO2" EXACT []
synonym: "Decreased Partial Pressure of Blood Oxygen" EXACT []
synonym: "Decreased PO2" EXACT []
synonym: "PO2 Decreased" EXACT []
is_a: MP:0002329 ! Abnormal Blood Gas Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000820
name: Hematopoietic System Phenotype
def: "The observable morphological and physiological characteristics of the human blood cells or the organs associated with the development and formation of blood cells that are manifested through development and lifespan." []
synonym: "Haematopoietic System Phenotype" EXACT []
synonym: "Haemopoietic System Phenotype" EXACT []
synonym: "Hemopoietic System Phenotype" EXACT []
is_a: OGMS:0000023 ! Phenotype
property_value: http://purl.org/dc/elements/1.1/source MP:0005397
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000821
name: Normal Hematopoietic System Phenotype
def: "A phenotype of the body's hematopoietic system  that is not clinically abnormal." []
is_a: SCDO:1000820 ! Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000822
name: Normal Red Blood Cell Count
def: "When the number of red blood cells in a specified volume of blood falls in the normal range." []
synonym: "Normal RBC Count" EXACT []
synonym: "RBC Count Normal" EXACT []
synonym: "Red Blood Cell Count Normal" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000823
name: Normal White Blood Cell Count
def: "When the number of white blood cells in a specified volume of blood falls in the normal range." []
synonym: "Normal WBC Count" EXACT []
synonym: "WBC Count Normal" EXACT []
synonym: "White Blood Cell Count Normal" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000824
name: Normal Platelet Count
def: "When the number of platelets in a specified volume of blood falls in the normal range." []
synonym: "Platelet Count Normal" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000825
name: Normal Mean Corpuscular Volume
def: "When the average volume or size of a single red blood cell falls in the normal range." []
synonym: "MCV Normal" EXACT []
synonym: "Mean Cell Volume Normal" EXACT []
synonym: "Mean Corpuscular Volume Normal" EXACT []
synonym: "Normal MCV" EXACT []
synonym: "Normal Mean Cell Volume" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000826
name: Normal Mean Corpuscular Hemoglobin
def: "When the average amount of hemoglobin per red blood cell (calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood) falls in the normal range." []
synonym: "MCH Normal" EXACT []
synonym: "Mean Cell Hemoglobin Normal" EXACT []
synonym: "Mean Corpuscular Hemoglobin Level Normal" EXACT []
synonym: "Mean Corpuscular Hemoglobin Normal" EXACT []
synonym: "Normal MCH" EXACT []
synonym: "Normal Mean Cell Hemoglobin" EXACT []
synonym: "Normal Mean Corpuscular Hemoglobin" EXACT []
synonym: "Normal Mean Corpuscular Hemoglobin Level" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000827
name: Normal Mean Corpuscular Hemoglobin Concentration
def: "When the amount of hemoglobin in a given volume of packed red blood cells falls in the normal range." []
synonym: "MCHC Normal" EXACT []
synonym: "Mean Corpuscular Hemoglobin Concentration Normal" EXACT []
synonym: "Normal MCHC" EXACT []
synonym: "Normal Mean Cell Hemoglobin Concentration" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000828
name: Normal Red Blood Cell Distribution Width
def: "When the range of variation of red blood cell (RBC) volume falls in the normal range." []
synonym: "Normal RBC Distribution Width" EXACT []
synonym: "Normal RCDW" EXACT []
synonym: "RBC Distribution Width Normal" EXACT []
synonym: "RCDW Normal" EXACT []
synonym: "Red Blood Cell Distribution Width Normal" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000829
name: Normal Serum Creatinine
def: "When the level of serum creatinine is in the normal range." []
synonym: "Normal Serum Creatinine Level" EXACT []
synonym: "Serum Creatinine Level Normal" EXACT []
synonym: "Serum Creatinine Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000830
name: Normal Serum Alanine Aminotransferase
def: "When the level of serum alanine aminotransferase is in the normal range." []
synonym: "ALT Level Normal" EXACT []
synonym: "ALT Normal" EXACT []
synonym: "Normal Alanine Aminotransferase Level" EXACT []
synonym: "Normal Alanine Transaminase" EXACT []
synonym: "Normal ALT" EXACT []
synonym: "Normal ALT Level" EXACT []
synonym: "Normal Serum Alanine Aminotransferase Level" EXACT []
synonym: "Serum Alanine Aminotransferase Level Normal" EXACT []
synonym: "Serum Alanine Aminotransferase Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000831
name: Normal Serum Aspartate Aminotransferase
def: "When the level of serum aspartate aminotransferase is in the normal range." []
synonym: "AST Level Normal" EXACT []
synonym: "AST Normal" EXACT []
synonym: "Normal Aspartate Aminotransferase" EXACT []
synonym: "Normal AST" EXACT []
synonym: "Normal AST Level" EXACT []
synonym: "Normal Serum Aspartate Aminotransferase Level" EXACT []
synonym: "Normal Serum AST" EXACT []
synonym: "Serum Aspartate Aminotransferase Normal" EXACT []
synonym: "Serum AST Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000832
name: Normal Serum Alkaline Phosphatase
def: "When the level of serum alkaline aminotransferase is in the normal range." []
synonym: "Alkaline Phosphatase Level Normal" EXACT []
synonym: "Alkaline Phosphatase Normal" EXACT []
synonym: "AP Level Normal" EXACT []
synonym: "AP Normal" EXACT []
synonym: "Normal AP" EXACT []
synonym: "Normal AP Level" EXACT []
synonym: "Normal Serum Alkaline Phosphatase Level" EXACT []
synonym: "Normal Serum AP Level" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000833
name: Normal Lactate Dehydrogenase Level
def: "When the level of the enzyme lactate dehydrogenase in the serum is in the normal range." []
synonym: "Lactate Dehydrogenase Level Normal" EXACT []
synonym: "Lactate Dehydrogenase Normal" EXACT []
synonym: "LD Level Normal" EXACT []
synonym: "LD Normal" EXACT []
synonym: "LDH Level Normal" EXACT []
synonym: "LDH Normal" EXACT []
synonym: "Normal LD" EXACT []
synonym: "Normal LD Level" EXACT []
synonym: "Normal LDH" EXACT []
synonym: "Normal LDH Level" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000834
name: Normal Reticulocyte Count
def: "When the number of reticulocytes in a specified volume of blood falls in the normal range." []
synonym: "Reticulocyte Count Normal" EXACT []
is_a: SCDO:1000821 ! Normal Hematopoietic System Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000835
name: Normal Total Serum Bilirubin
def: "When the total bilirubin level in the serum is in the normal range." []
synonym: "Serum Bilirubin Total Normal" EXACT []
synonym: "Total Serum Bilirubin Level Normal" EXACT []
synonym: "Total Serum Bilirubin Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000836
name: Normal Urine Albumin Concentration
def: "When the concentration of urinary albumin falls in the normal range." []
synonym: "Normal Urinary Albumin Concentration" EXACT []
synonym: "Urinary Albumin Concentration Normal" EXACT []
synonym: "Urine Albumin Concentration Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000837
name: Normal Urine Creatinine Level
def: "When the concentration of urine creatinine falls in the normal range." []
synonym: "Creatinine Urine Normal" EXACT []
synonym: "Normal Urinary Creatinine" EXACT []
synonym: "Normal Urinary Creatinine Level" EXACT []
synonym: "Normal Urine Creatinine" EXACT []
synonym: "Urinary Creatinine Level Normal" EXACT []
synonym: "Urine Creatinine Level Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not available" xsd:string

[Term]
id: SCDO:1000838
name: Normal Partial Pressure of Oxygen
def: "When the pressure exerted by oxygen dissolved in the blood falls in the normal range." []
synonym: "Normal Oxygen Tension" EXACT []
synonym: "Normal PaO2" EXACT []
synonym: "Normal Partial Pressure of Blood Oxygen" EXACT []
synonym: "Normal PO2" EXACT []
synonym: "PaO2 Normal" EXACT []
synonym: "Partial Pressure of Blood Oxygen Normal" EXACT []
synonym: "Partial Pressure of Oxygen Normal" EXACT []
synonym: "PO2 Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000839
name: Normal Partial Pressure of Carbon Dioxide
def: "When the pressure exerted by carbon dioxide dissolved in the blood falls in the normal range." []
synonym: "Normal Carbon Dioxide Tension" EXACT []
synonym: "Normal PaCO2" EXACT []
synonym: "Normal Partial Pressure of Blood Carbon Dioxide" EXACT []
synonym: "PaCO2 Normal" EXACT []
synonym: "Partial Pressure of Blood Carbon Dioxide Normal" EXACT []
synonym: "Partial Pressure of Carbon Dioxide Normal" EXACT []
is_a: SCDO:1000812 ! Normal Metabolism/Homeostasis Phenotype
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000840
name: Decreased Partial Pressure of Carbon Dioxide
def: "An abnormal reduction in the pressure exerted by carbon dioxide dissolved in the blood." []
synonym: "Decreased PaCO2" EXACT []
synonym: "Decreased Partial Pressure of Blood Carbon Dioxide" EXACT []
synonym: "Decreased PCO2" EXACT []
synonym: "PaCO2 Decreased" EXACT []
synonym: "Partial Pressure of Blood Carbon Dioxide Decreased" EXACT []
synonym: "PCO2 Decreased" EXACT []
is_a: MP:0002329 ! Abnormal Blood Gas Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000841
name: Increased Partial Pressure of Carbon Dioxide
def: "An abnormal increase in the pressure exerted by carbon dioxide dissolved in the blood." []
synonym: "Elevated Partial Pressure of Carbon Dioxide" EXACT []
synonym: "Increased PaCO2" EXACT []
synonym: "Increased Partial Pressure of Blood Carbon Dioxide" EXACT []
synonym: "Increased PCO2" EXACT []
synonym: "PaCO2 Increased" EXACT []
synonym: "Partial Pressure of Carbon Dioxide Increased" EXACT []
synonym: "PCO2 Increased" EXACT []
synonym: "Raised Partial Pressure of Carbon Dioxide" EXACT []
is_a: MP:0002329 ! Abnormal Blood Gas Level
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000842
name: Hypocapnia
def: "Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood." []
synonym: "Hypocarbia" EXACT []
xref: MESH:D016857
is_a: MP:0002329 ! Abnormal Blood Gas Level
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D016857
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000842 xsd:string

[Term]
id: SCDO:1000843
name: Hypercapnia
def: "A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood." []
synonym: "Hypercarbia" EXACT []
xref: MESH:D006935
is_a: MP:0002329 ! Abnormal Blood Gas Level
property_value: SCDO:0000340 http://purl.bioontology.org/ontology/MESH/D006935
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000843 xsd:string

[Term]
id: SCDO:1000844
name: Hemoglobin S Present
def: "When the abnormal hemoglobin, hemoglobin S (HbS), has been detected in a blood sample." []
synonym: "Haemoglobin S in Blood" EXACT []
synonym: "Haemoglobin S Present" EXACT []
synonym: "HbS in Blood" EXACT []
synonym: "HbS Present" EXACT []
synonym: "Hemoglobin S in Blood" EXACT []
is_a: HP:0020061 ! Abnormal Hemoglobin Concentration
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000847
name: SickleInAfrica CDE - Type of Visit Question
def: "The Sickle in Africa core data element that records the type of visit undertaken by a patient." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000496 ! is question type Multiple Choice Single Selection Question
relationship: SCDO:1000526 EUPATH:0000050 ! has answer option Routine Clinical Visit
relationship: SCDO:1000526 SCDO:1000849 ! has answer option Acute Clinical Visit
relationship: SCDO:1000526 SCDO:1000900 ! has answer option First Visit
relationship: SCDO:1000526 SCDO:1000901 ! has answer option Follow-Up Visit
relationship: SCDO:1000528 NCIT:C103165 ! collects Subject Visit Type
property_value: SCDO:1000517 "1, Routine\n2, Acute\n3, Review\n4, First visit" xsd:string
property_value: SCDO:1000518 "Type of visit" xsd:string
property_value: SCDO:1000519 "visit_type" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000749 "dropdown" xsd:string

[Term]
id: SCDO:1000849
name: Acute Clinical Visit
def: "A clinical visit occuring because of an acute (severe with sudden onset) health condition." []
is_a: NCIT:C103165 ! Subject Visit Type
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Few but definitions not specific enough" xsd:string

[Term]
id: SCDO:1000850
name: SickleInAfrica CDE - Medical Record Number Question
def: "The Sickle in Africa core data element that records the patient's medical record number." []
synonym: "Medical record number" EXACT []
synonym: "MRN" EXACT []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 NCIT:C81262 ! collects Medical Record Number
property_value: SCDO:1000518 "Medical record number (MRN)" xsd:string
property_value: SCDO:1000519 "medical_record_number" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000854
name: SickleInAfrica CDE - Hospital Name Question
def: "The Sickle in Africa core data element that records the name of the hospital that a patient visited." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000855 ! collects Hospital Name
property_value: SCDO:1000518 "Hospital name" xsd:string
property_value: SCDO:1000519 "hospital_name" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "5" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000855
name: Hospital Name
def: "The name of the hospital visited by a patient." []
is_a: EUPATH:0000310 ! Information on Observation Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000856
name: SickleInAfrica CDE - First Name Question
def: "The Sickle in Africa core data element that records a respondent's first name." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000858 ! collects First Name
property_value: SCDO:1000518 "First name" xsd:string
property_value: SCDO:1000519 "first_name" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "6" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000857
name: SickleInAfrica CDE - Middle Name Question
def: "The Sickle in Africa core data element that records a respondent's middle name." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000860 ! collects Middle Name
property_value: SCDO:1000518 "Middle name" xsd:string
property_value: SCDO:1000519 "middle_name" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "7" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000858
name: First Name
def: "A first name is a name that denotes a specific individual between members of a group of individuals, whose members usually share the same surname." []
synonym: "Forename" EXACT []
synonym: "Given Name" EXACT []
xref: sio:FirstName
is_a: NCIT:C25191 ! Person Name
property_value: SCDO:0000340 http://semanticscience.org/resource/FirstName
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000858 xsd:string

[Term]
id: SCDO:1000860
name: Middle Name
def: "A middle name is a name assigned to an individual that is not the first or last name." []
xref: sio:MiddleName
is_a: NCIT:C25191 ! Person Name
property_value: SCDO:0000340 http://semanticscience.org/resource/MiddleName
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000860 xsd:string

[Term]
id: SCDO:1000861
name: Last Name
def: "A last name (surname) is a name added to a given name and is part of a personal name and is often the family name." []
xref: sio:LastName
is_a: NCIT:C25191 ! Person Name
property_value: SCDO:0000340 http://semanticscience.org/resource/LastName
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000861 xsd:string

[Term]
id: SCDO:1000862
name: SickleInAfrica CDE - Last Name Question
def: "The Sickle in Africa core data element that records a respondent's last name." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000861 ! collects Last Name
property_value: SCDO:1000518 "Last name" xsd:string
property_value: SCDO:1000519 "last_name" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "8" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000863
name: SickleInAfrica CDE - Height Question
def: "The Sickle in Africa core data element that records a respondent's height." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0000149 ! collects Body Height
relationship: SCDO:1000771 UO:0000015 ! has answer standard unit Centimeter
property_value: SCDO:1000518 "Height/Length" xsd:string
property_value: SCDO:1000519 "height_length" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000737 "cm" xsd:string
property_value: SCDO:1000739 "12" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000866
name: SickleInAfrica CDE - Weight Question
def: "The Sickle in Africa core data element that records a respondent's measured weight." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:0000727 ! collects Measured Weight
relationship: SCDO:1000771 UO:0000009 ! has answer standard unit Kilogram
property_value: SCDO:1000518 "Weight" xsd:string
property_value: SCDO:1000519 "weight" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000737 "kg" xsd:string
property_value: SCDO:1000739 "13" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000868
name: SickleInAfrica CDE - Ethnic Group Question
def: "The Sickle in Africa core data element that records the ethnic group to which a respondent belongs." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 NCIT:C16564 ! collects Ethnic Group
property_value: SCDO:1000518 "Ethnic Group" xsd:string
property_value: SCDO:1000519 "tribe" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "16" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000869
name: SickleInAfrica CDE - Religion Question
def: "The Sickle in Africa core data element that records the religion of a respondent." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:0000981 ! collects Religion
property_value: SCDO:1000518 "Religion" xsd:string
property_value: SCDO:1000519 "religion" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "17" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000870
name: SickleInAfrica CDE - Region Question
def: "The Sickle in Africa core data element that records the region in which the respondent lives." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 NCIT:C16632 ! collects Geographic Area
property_value: SCDO:1000518 "Region" xsd:string
property_value: SCDO:1000519 "region" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "18" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000871
name: Street Name
def: "A street name is the token given to identify a particular street." []
xref: SIO:000766
is_a: NCIT:C19332 ! Personal Attribute
property_value: SCDO:0000340 SIO:000766
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000871 xsd:string

[Term]
id: SCDO:1000872
name: SickleInAfrica CDE - Street Question
def: "The Sickle in Africa core data element that records the name of the street in which the respondent lives." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000871 ! collects Street Name
property_value: SCDO:1000518 "Street" xsd:string
property_value: SCDO:1000519 "street" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "19" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000873
name: SickleInAfrica CDE - Nearest Landmark Question
def: "The Sickle in Africa core data element that records the landmark that is nearest to where the participant lives." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000874 ! collects Nearest Geographical Landmark
property_value: SCDO:1000518 "Nearest landmark" xsd:string
property_value: SCDO:1000519 "nearest_landmark" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "20" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000874
name: Nearest Geographical Landmark
def: "A recognizable natural or artificial geographic feature, used for navigation (often visible from long distances), that is nearest to where the participant lives." []
is_a: NCIT:C19332 ! Personal Attribute
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000875
name: Next of Kin Name
def: "The name of a respondent's next of kin." []
is_a: NCIT:C25191 ! Person Name
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000876
name: SickleInAfrica CDE - Telephone 1 Question
def: "The Sickle in Africa core data element that records the participant's primary telephone number." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000882 ! collects Telephone Number 1
property_value: SCDO:1000518 "Telephone 1" xsd:string
property_value: SCDO:1000519 "telephone_1" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "21" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000877
name: SickleInAfrica CDE - Telephone 2 Question
def: "The Sickle in Africa core data element that records the participant's secondary telephone number." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000883 ! collects Telephone Number 2
property_value: SCDO:1000518 "Telephone 2" xsd:string
property_value: SCDO:1000519 "telephone_2" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "22" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000878
name: SickleInAfrica CDE - Next of Kin Name Question
def: "The Sickle in Africa core data element that records the name of the participant's next of kin." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000875 ! collects Next of Kin Name
property_value: SCDO:1000518 "Next of kin name" xsd:string
property_value: SCDO:1000519 "next_of_kin_name" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "23" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000879
name: SickleInAfrica CDE - Next of Kin Number Question
def: "The Sickle in Africa core data element that records the telephone number of the participant's next of kin." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000884 ! collects Next of Kin Telephone Number
property_value: SCDO:1000518 "Next of kin telephone number" xsd:string
property_value: SCDO:1000519 "next_of_kin_telephone_numb" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "24" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000880
name: SickleInAfrica CDE - Relationship to Participant Question
def: "The Sickle in Africa core data element that records the participant's next of kin's relationship to the participant." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000502 ! is question type Open-Ended Question - Free Text
relationship: SCDO:1000528 SCDO:1000885 ! collects Next of Kin Relationship to Participant
property_value: SCDO:1000518 "Relationship to participant" xsd:string
property_value: SCDO:1000519 "next_of_kin_relationship" xsd:string
property_value: SCDO:1000735 "Demographics" xsd:string
property_value: SCDO:1000739 "25" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000882
name: Telephone Number 1
def: "A respondent's primary telephone number." []
is_a: NCIT:C40978 ! Telephone Number
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000883
name: Telephone Number 2
def: "A respondent's secondary telephone number." []
is_a: NCIT:C40978 ! Telephone Number
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000884
name: Next of Kin Telephone Number
def: "The telephone number of a respondent's next of kin." []
is_a: NCIT:C40978 ! Telephone Number
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000885
name: Next of Kin Relationship to Participant
def: "The relationship that the participant's next of kin has with the participant." []
synonym: "Next of Kin Relationship to Patient" EXACT []
is_a: NCIT:C19332 ! Personal Attribute
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000886
name: SickleInAfrica CDE - Blood Transfusion Question
def: "The Sickle in Africa core data element that records whether the participant was given a blood transfusion." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:1000534 ! collects Blood Transfusion Since Last Visit
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Blood transfusion" xsd:string
property_value: SCDO:1000519 "blood_transfusion" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "7" xsd:integer
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000887
name: SickleInAfrica CDE - Units Transfused Question
def: "The Sickle in Africa core data element that records the number of units of blood that a participant was given during a blood transfusion." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 SCDO:1000888 ! collects Number of Units Transfused
property_value: SCDO:1000518 "Units transfused" xsd:string
property_value: SCDO:1000519 "units_transfused" xsd:string
property_value: SCDO:1000735 "Management Details" xsd:string
property_value: SCDO:1000739 "9" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000742 "[blood_transfusion] = \"Yes\"" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000888
name: Number of Units Transfused
def: "The number of units of blood that a patient received during a blood transfusion." []
is_a: SCDO:1000590 ! SCD Management Details
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000889
name: SickleInAfrica CDE - Difficulty in Breathing Question
def: "The Sickle in Africa core data element that records whether a participant has difficulty in breathing." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 HP:0002098 ! collects Respiratory Distress
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Difficulty in breathing" xsd:string
property_value: SCDO:1000519 "difficulty_in_breathing" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000739 "4" xsd:integer
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000890
name: SickleInAfrica CDE - Systolic Blood Pressure Question
def: "The Sickle in Africa core data element that records a participant's systolic blood pressure." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 NCIT:C25298 ! collects Systolic Blood Pressure
relationship: SCDO:1000771 UO:0000272 ! has answer standard unit mmHg
property_value: SCDO:1000518 "Systolic blood pressure" xsd:string
property_value: SCDO:1000519 "systolic_blood_press" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000737 "mmHg" xsd:string
property_value: SCDO:1000739 "5" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000891
name: SickleInAfrica CDE - Diastolic Blood Pressure Question
def: "The Sickle in Africa core data element that records a participant's diastolic blood pressure." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 NCIT:C25299 ! collects Diastolic Blood Pressure
relationship: SCDO:1000771 UO:0000272 ! has answer standard unit mmHg
property_value: SCDO:1000518 "Diastolic blood pressure" xsd:string
property_value: SCDO:1000519 "diastol_blood_press" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000737 "mmHg" xsd:string
property_value: SCDO:1000739 "6" xsd:integer
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000894
name: SickleInAfrica CDE - Priapism Question
def: "The Sickle in Africa core data element that records whether a participant has priapism." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 SCDO:0000923 ! collects Priapism
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Priapism" xsd:string
property_value: SCDO:1000519 "priapism" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000739 "7" xsd:integer
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000895
name: SickleInAfrica CDE - Chest Pain Question
def: "The Sickle in Africa core data element that records whether a participant has chest pain." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 HP:0100749 ! collects Chest Pain
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Chest Pain" xsd:string
property_value: SCDO:1000519 "chest_pain" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000739 "8" xsd:integer
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000896
name: SickleInAfrica CDE - Anaemia Question
def: "The Sickle in Africa core data element that records whether a participant has anaemia." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 HP:0001903 ! collects Anemia
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Anaemia" xsd:string
property_value: SCDO:1000519 "anaemia" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000739 "9" xsd:integer
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000897
name: SickleInAfrica CDE - Jaundice Question
def: "The Sickle in Africa core data element that records whether a participant has jaundice." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000498 ! is question type Yes-No Question
relationship: SCDO:1000526 OPMI:0000023 ! has answer option Yes
relationship: SCDO:1000526 OPMI:0000024 ! has answer option No
relationship: SCDO:1000528 HP:0000952 ! collects Jaundice
property_value: SCDO:1000517 "1, Yes\n0, No" xsd:string
property_value: SCDO:1000518 "Jaundice" xsd:string
property_value: SCDO:1000519 "jaundice" xsd:string
property_value: SCDO:1000735 "Vital Signs" xsd:string
property_value: SCDO:1000739 "10" xsd:integer
property_value: SCDO:1000749 "yesno" xsd:string

[Term]
id: SCDO:1000898
name: SickleInAfrica CDE - Urea Question
def: "The Sickle in Africa core data element that collects the concentration of urea in the respondent's blood." []
is_a: SCDO:1000509 ! SickleInAfrica Core Data Element
relationship: SCDO:1000525 SCDO:1000501 ! is question type Open-Ended Question - Restricted
relationship: SCDO:1000528 EUPATH:0021227 ! collects Blood Urea Concentration
relationship: SCDO:1000771 NCIT:C64387 ! has answer standard unit Millimole per Liter
property_value: SCDO:1000518 "Urea" xsd:string
property_value: SCDO:1000519 "urea" xsd:string
property_value: SCDO:1000735 "Kidney Function Assay (Phenx protocols PX141401, PX141501 and PX141601 unless stated otherwise)" xsd:string
property_value: SCDO:1000737 "mmol/L" xsd:string
property_value: SCDO:1000739 "2" xsd:integer
property_value: SCDO:1000741 "Number" xsd:string
property_value: SCDO:1000749 "text" xsd:string

[Term]
id: SCDO:1000900
name: First Visit
def: "A clinical visit that is the patient's first clinical visit." []
is_a: NCIT:C103165 ! Subject Visit Type
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Term]
id: SCDO:1000901
name: Follow-Up Visit
def: "A clinical visit that is a follow-up for a previous visit." []
synonym: "Review Visit" EXACT []
is_a: NCIT:C103165 ! Subject Visit Type
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "Not relevant to context of sickle cell" xsd:string

[Term]
id: STATO:0000091
name: Genome Wide Association Study
def: "Genome wide association study is a kind of study whose objective is to detect association between genetic markers (SNP or otherwise) accross the genome and a trait which may be a disease or another phenotype (e.g. trait of agronomic relevance in animal or plant studies). Genome wide association study compare the allele frequencies in 2 populations, one free of the trait used as control, the other one showing the trait use as 'case'. GWAS studies implement case-control design." []
synonym: "GWAS" EXACT []
xref: STATO:0000091
is_a: SCDO:0000437 ! Epidemiologic Studies
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/STATO_0000091 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000450 xsd:string

[Term]
id: SYMP:0000412
name: Anxiety
def: "A neurological and physiological symptom characterized by a painful or apprehensive uneasiness of mind usually over an impending or anticipated ill." []
comment: Physical symptoms include increased blood pressure (rapid heartbeat), trembling or dizziness.
synonym: "Anxiety Symptoms" EXACT []
synonym: "Panic" EXACT []
synonym: "Worry" EXACT []
xref: SYMP:0000412
is_a: HP:0000708 ! Behavioural Abnormality
is_a: SCDO:0000746 ! Mental Health
is_a: SCDO:0000954 ! Quality of Life Related SCD Symptoms and Complications
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: http://purl.org/dc/elements/1.1/source http://www.apa.org/topics/anxiety/ xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/SYMP_0000412 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000068 xsd:string

[Term]
id: SYMP:0019161
name: Muscle Pain
def: "Muscle pain is a pain characterized by pain in one or more muscles." []
synonym: "Myalgia" EXACT []
xref: SYMP:0019161
is_a: SCDO:0000851 ! Pain
relationship: SCDO:0000664 SCDO:0000050 ! treated with Analgesic
relationship: SCDO:0000664 SCDO:0000057 ! treated with Anti-Inflammatory Agent
relationship: SCDO:0000664 SCDO:0000262 ! treated with Cognitive Therapy
relationship: SCDO:0000664 SCDO:1000020 ! treated with Treatment of Precipitating Factors
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
property_value: SCDO:0000303 "Provide source for additional info" xsd:string
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/SYMP_0019161 xsd:string
property_value: SCDO:0000661 "Over-stretching of one muscle or a group of muscles, trauma, infections ( influenza, Lyme, Ebola, Dengue fever, Chicungunya fever, Babesiosis, Malaria, Toxoplasmosis, Hemorrhage fever, polio, Rocky Mountain spotted fever, Trichinosis), vaccines, muscle hematoma, autoimmune disorders ( lupus, polymyalgia, polymyositis, nutricional deficiencies, chronic fatigue syndrome, acute rejection after heart transplant surgery, rhabdomyolysis, severe potassium deficiency, fibromialgia, muscle abscess , reaction to drugs ( statins, fibrates, ACE inhibitors, cocaine), repetitive strain injury,withdrawal syndrome of certain drugs ( corticosteroids, opioids, barbiturates, benzodiazepines, caffeine, alcohol)." xsd:string
property_value: SCDO:0000662 "Pain of a muscle or a group of muscles." xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000779 xsd:string

[Term]
id: UO:0000000
name: Unit of Measurement
def: "A standardized quantity of a physical quality." []
synonym: "Unit" EXACT []
synonym: "Unit of Measure" EXACT []
synonym: "Units" EXACT []
xref: UO:0000000
is_a: SCDO:1000472 ! Data Standards
property_value: SCDO:0000340 UO:0000000
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000478 xsd:string

[Term]
id: UO:0000001
name: Length Unit
def: "A unit which is a standard measure of the distance between two points." []
xref: UO:0000001
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000001
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000864 xsd:string

[Term]
id: UO:0000002
name: Mass Unit
def: "A unit which is a standard measure of the amount of matter/energy of a physical object." []
xref: UO:0000002
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000002
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000628 xsd:string

[Term]
id: UO:0000005
name: Temperature Unit
def: "A unit which is a standard measure of the average kinetic energy of the particles in a sample of matter." []
xref: UO:0000005
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000005
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000712 xsd:string

[Term]
id: UO:0000009
name: Kilogram
def: "A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France." []
xref: UO:0000009
is_a: UO:0000002 ! Mass Unit
property_value: SCDO:0000340 UO:0000009
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000867 xsd:string

[Term]
id: UO:0000015
name: Centimeter
def: "A length unit which is equal to one hundredth of a meter or 10^[-2] m." []
xref: UO:0000015
is_a: UO:0000001 ! Length Unit
property_value: SCDO:0000340 UO:0000015
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000865 xsd:string

[Term]
id: UO:0000025
name: pg
def: "A mass unit which is equal to 10^[-12] g." []
synonym: "picogram" EXACT []
xref: UO:0000025
is_a: UO:0000002 ! Mass Unit
property_value: SCDO:0000340 UO:0000025
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000629 xsd:string

[Term]
id: UO:0000051
name: Concentration Unit
def: "A unit which represents a standard measurement of how much of a given substance there is mixed with another substance." []
xref: UO:0000051
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000051
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000491 xsd:string

[Term]
id: UO:0000095
name: Volume Unit
def: "A unit which is a standard measure of the amount of space occupied by any substance, whether solid, liquid, or gas." []
xref: UO:0000095
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000095
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000622 xsd:string

[Term]
id: UO:0000104
name: fL
def: "A volume unit which is equal to 10^[-15] L." []
synonym: "cubic micrometre" EXACT []
synonym: "femtoliter" EXACT []
synonym: "femtolitre" EXACT []
synonym: "μm^3" EXACT []
xref: UO:0000104
is_a: UO:0000095 ! Volume Unit
property_value: SCDO:0000340 UO:0000104
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000623 xsd:string

[Term]
id: UO:0000109
name: Pressure Unit
def: "A unit which is a standard measure of the force applied to a given area." []
xref: UO:0000109
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000109
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000720 xsd:string

[Term]
id: UO:0000180
name: Mass Per Unit Volume
def: "A concentration unit which is a standard measure of the mass of a substance in a given volume (density)." []
comment: Definition from BioAssay Ontology
synonym: "Unit of Density" EXACT []
xref: UO:0000180
is_a: UO:0000051 ! Concentration Unit
property_value: SCDO:0000340 UO:0000180
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000506 xsd:string

[Term]
id: UO:0000186
name: Dimensionless Unit
def: "A unit which is a standard measure of physical quantity consisting of only a numerical number without any units." []
xref: UO:0000186
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000186
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000642 xsd:string

[Term]
id: UO:0000187
name: Percent
def: "A dimensionless ratio unit which denotes numbers as fractions of 100." []
synonym: "%" EXACT []
xref: UO:0000187
is_a: UO:0000190 ! Ratio
property_value: SCDO:0000340 UO:0000187
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000644 xsd:string

[Term]
id: UO:0000190
name: Ratio
def: "A dimensionless unit which denotes an amount or magnitude of one quantity relative to another." []
xref: UO:0000190
is_a: UO:0000186 ! Dimensionless Unit
property_value: SCDO:0000340 UO:0000190
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000643 xsd:string

[Term]
id: UO:0000200
name: Cell Concentration Unit
def: "A concentration unit which denotes the average cell number in a given volume." []
xref: UO:0000200
is_a: UO:0000051 ! Concentration Unit
property_value: SCDO:0000340 UO:0000200
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000503 xsd:string

[Term]
id: UO:0000272
name: mmHg
def: "A unit of pressure equal to the amount of fluid pressure one millimeter deep in mercury at zero degrees centigrade on Earth." []
synonym: "millimetres of mercury" EXACT []
xref: UO:0000272
is_a: UO:0000109 ! Pressure Unit
property_value: SCDO:0000340 UO:0000272
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000721 xsd:string

[Term]
id: UO:0000280
name: Rate Unit
def: "A unit which represents a standard measurement occurrence of a process per unit time." []
xref: UO:0000280
is_a: UO:0000000 ! Unit of Measurement
property_value: SCDO:0000340 UO:0000280
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000715 xsd:string

[Term]
id: UO:0000316
name: cells per microliter
def: "A unit of cell concentration which is equal to one cell in a volume of 1 microliter." []
synonym: "cells per microliter" EXACT []
synonym: "cells/µL" EXACT []
xref: UO:0000316
is_a: UO:0000200 ! Cell Concentration Unit
property_value: SCDO:0000340 UO:0000316
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000507 xsd:string

[Term]
id: VO:0000001
name: Vaccine
def: "A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine." []
xref: VO:0000001
is_a: SCDO:0000930 ! Infection Prophylaxis
relationship: SCDO:1110663 SCDO:1000144 ! in guideline Recommendations for the Management of Sickle Cell Disease in South Africa
relationship: SCDO:1110663 SCDO:1000145 ! in guideline National Guideline for the Control and Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000146 ! in guideline Management of Sickle Cell Disease - The United Republic of Tanzania
relationship: SCDO:1110663 SCDO:1000147 ! in guideline A Parental Guide to Managing Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000148 ! in guideline Standards for Clinical Care of Adults with Sickle Cell Disease in the UK
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000151 ! in guideline Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care
relationship: SCDO:1110663 SCDO:1000152 ! in guideline Evidence-Based Management of Sickle Cell Disease
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/VO_0000001 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001221 xsd:string

[Term]
id: VO:0000642
name: Influenza Virus Vaccine
def: "A viral vaccine that protects against infection with influenza virus." []
xref: VO:0000642
is_a: VO:0000001 ! Vaccine
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/VO_0000642 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0000642 xsd:string

[Term]
id: VO:0000675
name: Streptococcus Pneumoniae Vaccine
def: "A Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases." []
synonym: "Pneumococcal Vaccine" EXACT []
xref: VO:0000675
is_a: VO:0000001 ! Vaccine
relationship: SCDO:1110663 SCDO:1000149 ! in guideline Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit
relationship: SCDO:1110663 SCDO:1000150 ! in guideline Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada
relationship: SCDO:1110663 SCDO:1000154 ! in guideline ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children
property_value: SCDO:0000340 http://purl.obolibrary.org/obo/VO_0000675 xsd:string
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:0001109 xsd:string

[Term]
id: VT:0000202
name: Alkaline Phosphatase Level
def: "The amount of alkaline phosphatase present in a specified volume of blood." []
def: "The proportion, quantity, or volume in whole blood, serum, or plasma of this enzyme, which hydrolyzes orthophosphoric monoesters." []
synonym: "AP Level" EXACT []
synonym: "Blood Alkaline Phosphatase Amount" EXACT []
synonym: "Circulating Alkaline Phosphatase Level" EXACT []
synonym: "Circulating ALP Level" EXACT []
xref: VT:0000202
is_a: CMO:0000023 ! Blood Chemistry Measurement
relationship: SCDO:1000190 SCDO:1000663 ! obtained via diagnostic tool Alkaline Phosphatase Blood Test
relationship: SCDO:1000772 HP:0003155 ! has possible finding Elevated Serum Alkaline Phosphatase
relationship: SCDO:1000772 HP:0003282 ! has possible finding Decreased Serum Alkaline Phosphatase
relationship: SCDO:1000772 SCDO:1000832 ! has possible finding Normal Serum Alkaline Phosphatase
property_value: SCDO:0000340 VT:0000202
property_value: SCDO:1000288 "Sufficient" xsd:string
property_value: SCDO:1000910 SCDO:1000499 xsd:string

[Typedef]
id: RO:0002200
name: has phenotype
def: "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." []
xref: RO:0002200
property_value: SCDO:0000340 RO:0002200
property_value: SCDO:0000363 "no" xsd:string
property_value: SCDO:0000929 "metadata complete - requires restrictions and relationships" xsd:string

[Typedef]
id: RO:0002201
name: phenotype of
def: "Inverse of \"has phenotype\" object property." []
property_value: SCDO:0000303 "If required later, specify as inverse of \"has phenotype\" in Protege." xsd:string
property_value: SCDO:0000340 RO:0002201
property_value: SCDO:0000363 "no" xsd:string
property_value: SCDO:0000929 "metadata complete - requires restrictions and relationships" xsd:string

[Typedef]
id: RO:0002452
name: has symptom
def: "A relation that holds between a disease or an organism and a phenotype that is a symptom (subjective evidence of disease perceived by the patient)." []
xref: RO:0002452
property_value: SCDO:0000303 "Description adapted from RO. Suggest this description be updated in RO." xsd:string
property_value: SCDO:0000340 RO:0002452
is_a: RO:0002200 ! has phenotype

[Typedef]
id: RO:0003302
name: causes or contributes to condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." []
xref: RO:0003302
property_value: SCDO:0000340 RO:0003302
is_a: SCDO:1000183 ! causes or contributes to

[Typedef]
id: RO:0003303
name: causes condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." []
synonym: "results_in" EXACT []
xref: RO:0003303
property_value: SCDO:0000340 RO:0003303
is_a: SCDO:1000183 ! causes or contributes to

[Typedef]
id: RO:0003306
name: contributes to frequency of condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population." []
xref: RO:0003306
property_value: SCDO:0000340 RO:0003306
is_a: SCDO:1000015 ! modifies

[Typedef]
id: RO:0003307
name: ameliorates condition
def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." []
xref: RO:0003307
property_value: SCDO:0000340 RO:0003307
is_a: SCDO:1000015 ! modifies

[Typedef]
id: RO:0003309
name: exacerbates condition
def: "A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." []
xref: RO:0003309
property_value: SCDO:0000340 RO:0003309
is_a: SCDO:1000015 ! modifies

[Typedef]
id: RO:0003310
name: condition ameliorated by
def: "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity." []
xref: RO:0003310
property_value: SCDO:0000340 RO:0003310
is_a: SCDO:1000005 ! modified by

[Typedef]
id: RO:0003311
name: condition exacerbated by
def: "A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity." []
xref: RO:0003311
property_value: SCDO:0000340 RO:0003311
is_a: SCDO:1000005 ! modified by

[Typedef]
id: SCDO:0000031
name: age of onset modified by
def: "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the age of onset of the phenotype. Age of onset is defined as \"The age group in which disease manifestations appear.\" (HPO)" []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:1000005 ! modified by

[Typedef]
id: SCDO:0000469
name: has clinical code
def: "A relationship between a condition (phenotype or disease) and a relevant ICD-10-CM Diagnosis Code." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string

[Typedef]
id: SCDO:0000474
name: has output measurement
def: "A relation between a device (diagnostic device) and the recording of the output (diagnostic measurement) of the device." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:0000475
name: uses medical device
def: "A relation between a process (e.g. a form of therapy) and a medical device, where the medical device is used in the process." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:0000660
name: caused or contributed to by
def: "A relationship between a condition (a phenotype or disease) and an entity (a genotype or genetic variation) where the entity has a causal role for the condition." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:0000663
name: diagnosed using tool
def: "A relation between a phenotype that is a diagnosis and a diagnostic tool used in making the diagnosis." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:0000664
name: treated with
def: "A relation between a condition (phenotype or disease) and a type of treatment or a specific treatment, where the condition can be treated with the treatment." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "If required later, specify as inverse of \"treats\"." xsd:string

[Typedef]
id: SCDO:0000772
name: mortality modified by
def: "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the mortality (due to the phenotype) of the SCD sufferer." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:1000005 ! modified by

[Typedef]
id: SCDO:0001139
name: temporal pattern modified by
def: "A relationship between a phenotype and a disease modifier, where the disease modifier modifies the temporal pattern of the phenotype. Temporal pattern is defined as \"The speed at which disease manifestations appear and develop.\" (HPO)" []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:1000005 ! modified by

[Typedef]
id: SCDO:0001297
name: has essential measure
def: "A measure that is critical to the collection of the measure at hand or is necessary for the interpretation of results for the measure at hand. Without such information, the data collected would be incomplete or misleading." []
comment: Essential measures have been attributed according to information in PhenX.
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:0001364
name: has mode of inheritance
def: "A relation between a particular genotype or disorder and the pattern in which the particular genotype or disorder is passed from one generation to the next." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000005
name: modified by
def: "A relationship between a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy) and a disease modifier, where the condition, entity or process is modified by the disease modifier in some way." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000015
name: modifies
def: "A relationship between a disease modifier and a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy), where the disease modifier modifies the condition, entity or process in some way." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000018
name: treats
def: "A relation between a type of treatment or a specific treatment and a condition (phenotype or disease), where the type of treatment or specific treatment treat the condition." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "If required later, specify as inverse of \"treated with\"." xsd:string

[Typedef]
id: SCDO:1000171
name: has diagnostic device
def: "A relation between a Diagnostic Tool (test, method, assay, etc.) or the Diagnostic Measurement obtained from such a tool and a specific Diagnostic Device, where the Diagnostic Device is used in the application of the Diagnostic Tool or to obtain the Diagnostic Measurement." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000172
name: has causal genotype
def: "A relation between a condition (hemoglobinopathy) and the genotype that causes the condition." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:0000660 ! caused or contributed to by

[Typedef]
id: SCDO:1000175
name: is ICD-10-CM code type
def: "An object property that specifies the type of an ICD-10-CM code, whether Billable or Non-Billable." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
domain: SCDO:0000607 ! ICD-10-CM Diagnosis Codes
range: SCDO:1000100 ! ICD-10-CM Code Type

[Typedef]
id: SCDO:1000180
name: manifestation of
def: "A relationship that holds between a phenotype (i.e. manifestation) and a condition such as a disease (hemoglobinopathy), wherein the phenotype is evidence of the condition." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: RO:0002201 ! phenotype of

[Typedef]
id: SCDO:1000182
name: symptom of
def: "A relation between a phenotype that is a symptom (subjective evidence of disease perceived by the patient) and a disease." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: RO:0002201 ! phenotype of

[Typedef]
id: SCDO:1000183
name: causes or contributes to
def: "A relationship between 'a' and 'b', where 'a' has some causal role for 'b'." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000184
name: contributes to genotype
def: "A relationship between an entity (e.g. genetic variation such as mutation or specific allele) and a genotype, where the entity contributes to the genotype." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:1000183 ! causes or contributes to

[Typedef]
id: SCDO:1000188
name: studied in
def: "A relation between a condition (Hemoglobinopathy) and a form of research (type of study) that the condition was studied in." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000189
name: associated via
def: "A relation between a condition (disease or phenotype) and a type of linking association (e.g. age of onset association)." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000190
name: obtained via diagnostic tool
def: "A relationship between a diagnostic measurement and the diagnostic tool used to produce the measurement." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000191
name: used by diagnostic tool
def: "A relationship between a diagnostic device and the diagnostic tool by which the device is used." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000192
name: uses diagnostic device
def: "A relation between a diagnostic tool (test, method, assay, etc.) and a diagnostic device, where the diagnostic device is used in the application of the diagnostic tool." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000193
name: output of diagnostic device
def: "A relation between a diagnostic measurement and a diagnostic device, where the diagnostic measurement is the output of the diagnostic device." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000194
name: measures
def: "A relation between a diagnostic tool and the diagnostic measurement that it measures." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000196
name: has contributing genetic variation
def: "A relation between a genotype and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation contributes to the genotype." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:0000660 ! caused or contributed to by

[Typedef]
id: SCDO:1000199
name: induced by
def: "A condition (phenotype or disease) or event (adverse event) induced by an entity (e.g. a drug) or activity (e.g. exercise)." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:0000303 "The \"developmentally induced by\" object property in RO has the alternative term \"induced by\"." xsd:string

[Typedef]
id: SCDO:1000202
name: caused by
def: "A relationship between a condition (a phenotype or disease) and an entity (e.g. environment) or condition (phenotype or disease) which could be an existing condition or an event, where the entity or second condition has a causal role for the condition being described." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:0000660 ! caused or contributed to by

[Typedef]
id: SCDO:1000203
name: has risk factor
def: "A relation between a condition (disease or phenotype) and an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of the condition." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000204
name: risk factor for
def: "A relation between an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of a condition and the condition (disease or phenotype) that it increases the likelihood of." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000210
name: has causal or contributing genetic variation
def: "A relation between a condition (disease or phenotype) or an entity (molecular phenotype) and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation has some causal or contributing role that influences the condition or entity." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:0000660 ! caused or contributed to by

[Typedef]
id: SCDO:1000217
name: causes or contributes to molecular phenotype
def: "A relation between an entity (genotype) and a molecular phenotype, where the entity has some causal or contributing role that influences the molecular phenotype." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:1000183 ! causes or contributes to

[Typedef]
id: SCDO:1000218
name: has manifestation
def: "A relationship that holds between a condition such as a disease (hemoglobinopathy) and a phenotype (i.e. manifestation), where the phenotype is evidence of the condition." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: RO:0002200 ! has phenotype

[Typedef]
id: SCDO:1000219
name: diagnosed by
def: "A relation between a condition that is a diagnosis and a phenotype used in making the diagnosis." []

[Typedef]
id: SCDO:1000220
name: diagnosed using measurement
def: "A relation between an Abnormal Phenotype that is a diagnosis and a Diagnostic Measurement or Diagnostic Device Visual Output used in making the diagnosis." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1000222
name: causes molecular phenotype
def: "A relation between a genotype and a molecular phenotype, where the genotype has a causal role for the molecular phenotype." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:1000183 ! causes or contributes to

[Typedef]
id: SCDO:1000223
name: has causal molecular phenotype
def: "A relation between a condition (disease such as a Hemoglobinopathy) and a molecular phenotype, where the molecular phenotype is evidence of the condition." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
is_a: SCDO:0000660 ! caused or contributed to by

[Typedef]
id: SCDO:1000525
name: is question type
def: "A relationship between a Clinical or Research Assessment Data Element and a Clinical or Research Assessment Question Type." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string
domain: SCDO:1000474 ! Clinical or Research Assessment Data Element
range: SCDO:1000475 ! Clinical or Research Assessment Question Type

[Typedef]
id: SCDO:1000526
name: has answer option
def: "A relationship between a multiple choice data element and an answer option or a group of answer options that are provided to the respondent by the data element." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string
domain: SCDO:1000474 ! Clinical or Research Assessment Data Element

[Typedef]
id: SCDO:1000528
name: collects
def: "A relationship between a data element and the type of information that is collected by that data element." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string
domain: SCDO:1000474 ! Clinical or Research Assessment Data Element

[Typedef]
id: SCDO:1000771
name: has answer standard unit
def: "A relationship between a data element and the unit of measurement used, as a standard, for the information that is collected by the data element." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string
domain: SCDO:1000474 ! Clinical or Research Assessment Data Element
range: UO:0000000 ! Unit of Measurement

[Typedef]
id: SCDO:1000772
name: has possible finding
def: "A relationship between a Diagnostic Measurement and a Phenotype, where the Phenotype is a possible finding of the Diagnostic Measurement, depending on the value recorded for the Diagnostic Measurement." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
domain: SCDO:0000728 ! Diagnostic Measurement
range: HP:0000118 ! Abnormal Phenotype

[Typedef]
id: SCDO:1000773
name: diagnosed using finding
def: "A relationship between an Abnormal Phenotype that is a diagnosis of a condition and a Phenotype that is a finding from a Diagnostic Measurement, where the Phenotype that is a finding is used as evidence to diagnose patients with the Abnormal Phenotype that is a diagnosis." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
range: OGMS:0000023 ! Phenotype

[Typedef]
id: SCDO:1000782
name: has reference range standard unit
def: "A relationship between a Diagnostic Measurement and the Unit of Measurement used for the values provided by the data properties that specify upper (ULN) or lower (LLN) limit of normal for the Diagnostic Measurement." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string
property_value: SCDO:1000288 "None" xsd:string
domain: SCDO:0000728 ! Diagnostic Measurement
range: UO:0000000 ! Unit of Measurement

[Typedef]
id: SCDO:1000785
name: code requires phenotype
def: "A relationship between a clinical code (such as ICD10 code) and a Phenotype, where the code can only be applied in instances where the phenotype is present." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: SCDO:1110663
name: in guideline
def: "A relation between an entity (phenotypic, therapeutic or diagnostic concept) and a guideline or directive." []
property_value: http://purl.org/dc/elements/1.1/creator "SCDO (Jade Hotchkiss)" xsd:string

[Typedef]
id: associated_with
name: associated with
xref: so:associated_with
property_value: SCDO:0000340 "associated_with"