format-version: 1.2 ontology: uberon/subsets/life-stages-composite.obo property_value: http://purl.org/dc/elements/1.1/description "Life cycle stage subset of uberon composite-vertebrate ontology (includes species stage ontologies)" xsd:string [Term] id: HsapDv:0000001 name: human life cycle namespace: human_developmental_stage def: "Temporal interval that defines human life from the prenatal stage until late adulthood." [Bgee:curator] is_a: UBERON:0000104 ! life cycle [Term] id: HsapDv:0000003 name: Carnegie stage 01 namespace: human_developmental_stage def: "Embryonic stage defined by a fertilized oocyte and presence of pronuclei." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Starts at day 1 post-fertilization, beginning of the first week. xref: XUO:0000130 is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0000068 ! embryo stage [Term] id: HsapDv:0000004 name: cleavage stage namespace: human_developmental_stage def: "Embryonic stage consisting of division of cells in the early embryo." [UBERON:0000107] comment: The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0000068 ! embryo stage [Term] id: HsapDv:0000005 name: Carnegie stage 02 namespace: human_developmental_stage def: "Cleavage stage during which cell division occurs with reduction in cytoplasmic volume, and formation of inner and outer cell mass." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 2 and day 3 post-fertilization. xref: XUO:0000131 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000003 ! Carnegie stage 01 relationship: part_of HsapDv:0000004 ! cleavage stage [Term] id: HsapDv:0000007 name: Carnegie stage 03 namespace: human_developmental_stage def: "Blastula stage with the loss of the zona pellucida and the definition of a free blastocyst." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 4 and day 5 post-fertilization. xref: XUO:0000132 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000005 ! Carnegie stage 02 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: HsapDv:0000008 name: Carnegie stage 04 namespace: human_developmental_stage def: "Blastula stage during which the blastocyst becomes attached." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 5 and day 6 post-fertilization. xref: XUO:0000133 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000007 ! Carnegie stage 03 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: HsapDv:0000009 name: Carnegie stage 05 namespace: human_developmental_stage def: "Blastula stage during which implantation occurs." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 7 and day 12 post-fertilization, beginning of the second week. xref: XUO:0000134 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000008 ! Carnegie stage 04 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: HsapDv:0000011 name: Carnegie stage 06 namespace: human_developmental_stage def: "Gastrula stage during which the extraembryonic mesoderm and primitive streak appear." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 13 and day 15 post-fertilization. xref: XUO:0000135 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000009 ! Carnegie stage 05 relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: HsapDv:0000013 name: Carnegie stage 07 namespace: human_developmental_stage def: "Neurula stage during which the notochordal process appears, and gastrulation is continuing." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 15 and day 17 post-fertilization, beginning of the third week. xref: XUO:0000136 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000011 ! Carnegie stage 06 relationship: part_of UBERON:0000110 ! neurula stage [Term] id: HsapDv:0000014 name: Carnegie stage 08 namespace: human_developmental_stage def: "Neurula stage during which the primitive pit and the notochordal canal appear." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 17 and day 19 post-fertilization. xref: XUO:0000137 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000013 ! Carnegie stage 07 relationship: part_of UBERON:0000110 ! neurula stage [Term] id: HsapDv:0000016 name: Carnegie stage 09 namespace: human_developmental_stage def: "Organogenesis stage during which somites 1-3 appear, and neural folds, cardiac primordium, and head fold are present." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 19 and day 21 post-fertilization. xref: XUO:0000138 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000014 ! Carnegie stage 08 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000017 name: Carnegie stage 10 namespace: human_developmental_stage def: "Organogenesis stage during which somites 4-12 appear, and the neural fold fuses." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 22 and day 23 post-fertilization, beginning of the fourth week. xref: XUO:0000139 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000016 ! Carnegie stage 09 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000018 name: Carnegie stage 11 namespace: human_developmental_stage def: "Organogenesis stage during which somites 13-20 appear, and the rostral neuropore closes." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 23 and day 26 post-fertilization. xref: XUO:0000140 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000017 ! Carnegie stage 10 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000019 name: Carnegie stage 12 namespace: human_developmental_stage def: "Organogenesis stage during which somites 21-29 appear, and the caudal neuropore closes." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 26 and day 30 post-fertilization. xref: XUO:0000141 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000018 ! Carnegie stage 11 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000020 name: Carnegie stage 13 namespace: human_developmental_stage def: "Organogenesis developmental stage during which somite 30 appears, and leg buds, lens placode, pharyngeal arches are present." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 28 and day 32 post-fertilization, beginning of the fifth week. xref: XUO:0000142 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000019 ! Carnegie stage 12 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000021 name: Carnegie stage 14 namespace: human_developmental_stage def: "Organogenesis stage during which lens pit and optic cup appear." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 31 and day 35 post-fertilization. xref: XUO:0000143 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000020 ! Carnegie stage 13 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000022 name: Carnegie stage 15 namespace: human_developmental_stage def: "Organogenesis stage during which lens vesicle, nasal pit, and hand plate appear." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 35 and day 38 post-fertilization. xref: XUO:0000144 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000021 ! Carnegie stage 14 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000023 name: Carnegie stage 16 namespace: human_developmental_stage def: "Organogenesis stage during which nasal pits moved ventrally, and features are auricular hillocks, and foot plate." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 37 and day 42 post-fertilization, beginning of the sixth week. xref: XUO:0000145 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000022 ! Carnegie stage 15 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000024 name: Carnegie stage 17 namespace: human_developmental_stage def: "Organogenesis stage during which finger rays become visible." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 42 and day 44 post-fertilization. xref: XUO:0000146 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000023 ! Carnegie stage 16 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000025 name: Carnegie stage 18 namespace: human_developmental_stage def: "Organogenesis stage during which ossification commences." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 44 and day 48 post-fertilization, beginning of the seventh week. xref: XUO:0000147 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000024 ! Carnegie stage 17 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000026 name: Carnegie stage 19 namespace: human_developmental_stage def: "Organogenesis stage during which the straightening of the trunk starts." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 48 and day 51 post-fertilization. xref: XUO:0000148 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000025 ! Carnegie stage 18 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000027 name: Carnegie stage 20 namespace: human_developmental_stage def: "Organogenesis stage during which upper limbs are longer and bent at elbow." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 51 and day 53 post-fertilization, beginning of the eighth week. xref: XUO:0000149 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000026 ! Carnegie stage 19 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000028 name: Carnegie stage 21 namespace: human_developmental_stage def: "Organogenesis stage during which hands and feet turned inward." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 53 and day 54 post-fertilization. xref: XUO:0000150 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000027 ! Carnegie stage 20 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000029 name: Carnegie stage 22 namespace: human_developmental_stage def: "Organogenesis stage during which eyelids and external ears appear." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 54 and day 56 post-fertilization. xref: XUO:0000151 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000028 ! Carnegie stage 21 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000030 name: Carnegie stage 23 namespace: human_developmental_stage def: "Organogenesis stage during which the head, the body, and the limbs are rounded structures." [http://embryology.med.unsw.edu.au/wwwhuman/Stages/CStages.htm] comment: Usually starts between day 56 and day 60 post-fertilization. xref: XUO:0000152 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000029 ! Carnegie stage 22 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: HsapDv:0000031 name: Carnegie stage 05a namespace: human_developmental_stage def: "Carnegie developmental stage 5 defined by a solid trophoblast." [http://nmhm.washingtondc.museum/collections/hdac/Stages_Table.htm] xref: XUO:0000187 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000009 ! Carnegie stage 05 [Term] id: HsapDv:0000032 name: Carnegie stage 05b namespace: human_developmental_stage def: "Carnegie developmental stage 5 defined by a trophoblastic lacunae." [http://nmhm.washingtondc.museum/collections/hdac/Stages_Table.htm] xref: XUO:0000188 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000009 ! Carnegie stage 05 [Term] id: HsapDv:0000033 name: Carnegie stage 05c namespace: human_developmental_stage def: "Carnegie developmental stage 5 defined by a lacunar vascular circle." [http://nmhm.washingtondc.museum/collections/hdac/Stages_Table.htm] xref: XUO:0000189 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000009 ! Carnegie stage 05 [Term] id: HsapDv:0000034 name: Carnegie stage 06a namespace: human_developmental_stage def: "Carnegie developmental stage 6 during which chorionic villi appear." [http://nmhm.washingtondc.museum/collections/hdac/Stages_Table.htm] xref: XUO:0000190 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000011 ! Carnegie stage 06 [Term] id: HsapDv:0000035 name: Carnegie stage 06b namespace: human_developmental_stage def: "Carnegie developmental stage 6 during which the primitive streak appears." [http://nmhm.washingtondc.museum/collections/hdac/Stages_Table.htm] xref: XUO:0000191 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000011 ! Carnegie stage 06 [Term] id: HsapDv:0000037 name: fetal stage namespace: human_developmental_stage def: "Prenatal stage that starts with the fully formed embryo and ends at birth." [Bgee:curator] synonym: "fetus stage" RELATED [] synonym: "foetus stage" RELATED [] xref: EV:0300011 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000045 ! prenatal stage [Term] id: HsapDv:0000045 name: prenatal stage namespace: human_developmental_stage def: "Human developmental stage that starts with fertilization and ends with birth." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000001 ! human life cycle [Term] id: HsapDv:0000046 name: 9th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 8 and under 9 weeks of development." [Bgee:curator] comment: External genitalia begin to distinguish themselves as either male or female. Eyelids are completely closed, and vocal ligaments appear (see http://ehd.org/resources_bpd_documentation_english.php). xref: EV:0300012 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000197 ! third LMP month human stage [Term] id: HsapDv:0000047 name: 10th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 9 and under 10 weeks of development." [Bgee:curator] comment: The fingernails and toenails begin to develop and unique fingerprints appear. Ossification is underway in most bones (see http://ehd.org/resources_bpd_documentation_english.php). xref: EV:0300013 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000197 ! third LMP month human stage [Term] id: HsapDv:0000048 name: 11th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 10 and under 11 weeks of development." [Bgee:curator] comment: The nose and lips are completely formed, and external genitalia can be distinguished as male or female (see http://ehd.org/resources_bpd_documentation_english.php). xref: EV:0300030 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000197 ! third LMP month human stage [Term] id: HsapDv:0000049 name: 12th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 11 and under 12 weeks of development." [Bgee:curator] comment: Upper limb length has nearly reached its final proportion to body size (see http://ehd.org/resources_bpd_documentation_english.php). The assignation of this week to the fourth or third LMP month is debatable (see http://en.wikipedia.org/wiki/File:Prenatal_development_table.svg). xref: EV:0300014 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000198 ! fourth LMP month human stage [Term] id: HsapDv:0000050 name: 13th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 12 and under 13 weeks of development." [Bgee:curator] xref: EV:0300015 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000198 ! fourth LMP month human stage [Term] id: HsapDv:0000051 name: 14th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 13 and under 14 weeks of development." [Bgee:curator] xref: EV:0300016 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000198 ! fourth LMP month human stage [Term] id: HsapDv:0000052 name: 15th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 14 and under 15 weeks of development." [Bgee:curator] xref: EV:0300031 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000198 ! fourth LMP month human stage [Term] id: HsapDv:0000053 name: 16th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 15 and under 16 weeks of development." [Bgee:curator] comment: The assignation of this week to the fifth or fourth LMP month is debatable (see http://en.wikipedia.org/wiki/File:Prenatal_development_table.svg). xref: EV:0300017 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000199 ! fifth LMP month human stage [Term] id: HsapDv:0000054 name: 17th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 16 and under 17 weeks of development." [Bgee:curator] xref: EV:0300018 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000199 ! fifth LMP month human stage [Term] id: HsapDv:0000055 name: 18th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 17 and under 18 weeks of development." [Bgee:curator] xref: EV:0300019 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000199 ! fifth LMP month human stage [Term] id: HsapDv:0000056 name: 19th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 18 and under 19 weeks of development." [Bgee:curator] xref: EV:0300020 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000199 ! fifth LMP month human stage [Term] id: HsapDv:0000057 name: 20th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 19 and under 20 weeks of development." [Bgee:curator] comment: The cochlea has reached adult size within the fully developed inner ear (see http://ehd.org/resources_bpd_documentation_english.php). The assignation of this week to the sixth or fifth LMP month is debatable (see http://en.wikipedia.org/wiki/File:Prenatal_development_table.svg). xref: EV:0300021 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000200 ! sixth LMP month human stage [Term] id: HsapDv:0000058 name: 21st week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 20 and under 21 weeks of development." [Bgee:curator] comment: The lungs gain some ability to breathe air. This stage is considered the age of viability because survival outside the womb becomes possible for some fetuses (see http://ehd.org/resources_bpd_documentation_english.php). xref: EV:0300029 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000200 ! sixth LMP month human stage [Term] id: HsapDv:0000059 name: 22nd week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 21 and under 22 weeks of development." [Bgee:curator] xref: EV:0300022 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000200 ! sixth LMP month human stage [Term] id: HsapDv:0000060 name: 23rd week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 22 and under 23 weeks of development." [Bgee:curator] xref: EV:0300023 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000200 ! sixth LMP month human stage [Term] id: HsapDv:0000061 name: 24th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 23 and under 24 weeks of development." [Bgee:curator] comment: The eyelids reopen (see http://ehd.org/resources_bpd_documentation_english.php). xref: EV:0300024 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000200 ! sixth LMP month human stage [Term] id: HsapDv:0000062 name: 25th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 24 and under 25 weeks of development." [Bgee:curator] comment: The assignation of this week to the seventh or sixth LMP month is debatable (see http://en.wikipedia.org/wiki/File:Prenatal_development_table.svg). xref: EV:0300032 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000201 ! seventh LMP month human stage [Term] id: HsapDv:0000063 name: 26th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 25 and under 26 weeks of development." [Bgee:curator] xref: EV:0300025 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000201 ! seventh LMP month human stage [Term] id: HsapDv:0000064 name: 27th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 26 and under 27 weeks of development." [Bgee:curator] xref: EV:0300033 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000201 ! seventh LMP month human stage [Term] id: HsapDv:0000065 name: 28th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 27 and under 28 weeks of development." [Bgee:curator] xref: EV:0300026 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000201 ! seventh LMP month human stage [Term] id: HsapDv:0000066 name: 29th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 28 and under 29 weeks of development." [Bgee:curator] comment: The assignation of this week to the eighth or seventh LMP month is debatable (see http://en.wikipedia.org/wiki/File:Prenatal_development_table.svg). xref: EV:0300034 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000202 ! eighth LMP month human stage [Term] id: HsapDv:0000067 name: 30th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 29 and under 30 weeks of development." [Bgee:curator] xref: EV:0300035 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000202 ! eighth LMP month human stage [Term] id: HsapDv:0000068 name: 31st week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 30 and under 31 weeks of development." [Bgee:curator] xref: EV:0300036 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000202 ! eighth LMP month human stage [Term] id: HsapDv:0000069 name: 32nd week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 31 and under 32 weeks of development." [Bgee:curator] xref: EV:0300027 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000202 ! eighth LMP month human stage [Term] id: HsapDv:0000070 name: 33rd week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 32 and under 33 weeks of development." [Bgee:curator] comment: The assignation of this week to the eighth or ninth LMP month is debatable (see http://en.wikipedia.org/wiki/File:Prenatal_development_table.svg). is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000202 ! eighth LMP month human stage [Term] id: HsapDv:0000071 name: 34th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 33 and under 34 weeks of development." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000203 ! ninth LMP month human stage [Term] id: HsapDv:0000072 name: 35th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 34 and under 35 weeks of development." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000203 ! ninth LMP month human stage [Term] id: HsapDv:0000073 name: 36th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 35 and under 36 weeks of development." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000203 ! ninth LMP month human stage [Term] id: HsapDv:0000074 name: 37th week post-fertilization human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 36 and under 37 weeks of development." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000203 ! ninth LMP month human stage [Term] id: HsapDv:0000075 name: 38th week post-fertilization and over human stage namespace: human_developmental_stage def: "Fetal stage when the fetus is over 37 weeks of development and until birth." [Bgee:curator] comment: The assignation of this week to the ninth or tenth LMP month is debatable (see http://en.wikipedia.org/wiki/File:Prenatal_development_table.svg). is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000203 ! ninth LMP month human stage [Term] id: HsapDv:0000080 name: immature stage namespace: human_developmental_stage def: "Human developmental stage that covers the period from birth until 12 years old." [Bgee:curator] synonym: "0-12 years" EXACT [] synonym: "child" RELATED [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000001 ! human life cycle [Term] id: HsapDv:0000081 name: child stage namespace: human_developmental_stage def: "Immature stage that refers to child who is over 2 and under 13 years old." [Bgee:curator] synonym: "2-12 years" EXACT [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000080 ! immature stage [Term] id: HsapDv:0000084 name: 2-5 year-old child stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 24 months and under 6 years old." [Bgee:curator] synonym: "preschool child" RELATED [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000081 ! child stage [Term] id: HsapDv:0000085 name: 6-12 year-old child stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 6 and under 13 years old." [Bgee:curator] synonym: "prepubescent" RELATED [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000081 ! child stage [Term] id: HsapDv:0000086 name: adolescent stage namespace: human_developmental_stage def: "Mature stage that refers to an adolescent who is over 13 and under 19 years old." [Bgee:curator] synonym: "13-18 years" EXACT [] synonym: "teen" RELATED [] synonym: "teenager" RELATED [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000204 ! mature stage [Term] id: HsapDv:0000087 name: human adult stage namespace: human_developmental_stage def: "Human developmental stage that refers to an adult who is over 19." [Bgee:curator] synonym: "19+ years" EXACT [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000204 ! mature stage [Term] id: HsapDv:0000088 name: human early adulthood stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is under 45." [Bgee:curator] synonym: "19-44 years" EXACT [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000087 ! human adult stage [Term] id: HsapDv:0000089 name: young adult stage namespace: human_developmental_stage def: "Early adulthood that refers to an adult who is under 25." [Bgee:curator] synonym: "19-24 years" EXACT [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000088 ! human early adulthood stage [Term] id: HsapDv:0000090 name: 25-44 year-old human stage namespace: human_developmental_stage def: "Early adulthood that refers to an adult who is over 25 and under 45." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000088 ! human early adulthood stage [Term] id: HsapDv:0000091 name: human late adulthood stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 45." [Bgee:curator] synonym: "45+ years" EXACT [] synonym: "Middle Aged + Aged" RELATED [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000087 ! human adult stage [Term] id: HsapDv:0000092 name: human middle aged stage namespace: human_developmental_stage def: "Late adulthood that refers to an adult who is over 45 and under 65." [Bgee:curator] synonym: "45-64 years" EXACT [] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000091 ! human late adulthood stage [Term] id: HsapDv:0000094 name: 65-79 year-old human stage namespace: human_developmental_stage def: "Aged stage that refers to an adult who is under 80." [Bgee:curator] synonym: "elderly" RELATED [] is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0007222 ! late adult stage [Term] id: HsapDv:0000095 name: 80 year-old and over human stage namespace: human_developmental_stage def: "Aged stage that refers to an adult who is over 80." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000173 ! 79-year-old human stage relationship: part_of UBERON:0007222 ! late adult stage [Term] id: HsapDv:0000096 name: 2-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 2 and under 3 years old." [Bgee:curator] xref: EV:0300053 is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000084 ! 2-5 year-old child stage [Term] id: HsapDv:0000097 name: 3-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 3 and under 4 years old." [Bgee:curator] xref: EV:0300054 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000096 ! 2-year-old human stage relationship: part_of HsapDv:0000084 ! 2-5 year-old child stage [Term] id: HsapDv:0000098 name: 4-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 4 and under 5 years old." [Bgee:curator] xref: EV:0300055 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000097 ! 3-year-old human stage relationship: part_of HsapDv:0000084 ! 2-5 year-old child stage [Term] id: HsapDv:0000099 name: 5-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 5 and under 6 years old." [Bgee:curator] xref: EV:0300056 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000098 ! 4-year-old human stage relationship: part_of HsapDv:0000084 ! 2-5 year-old child stage [Term] id: HsapDv:0000100 name: 6-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 6 and under 7 years old." [Bgee:curator] xref: EV:0300057 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000099 ! 5-year-old human stage relationship: part_of HsapDv:0000085 ! 6-12 year-old child stage [Term] id: HsapDv:0000101 name: 7-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 7 and under 8 years old." [Bgee:curator] xref: EV:0300058 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000100 ! 6-year-old human stage relationship: part_of HsapDv:0000085 ! 6-12 year-old child stage [Term] id: HsapDv:0000102 name: 8-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 8 and under 9 years old." [Bgee:curator] xref: EV:0300059 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000101 ! 7-year-old human stage relationship: part_of HsapDv:0000085 ! 6-12 year-old child stage [Term] id: HsapDv:0000103 name: 9-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 9 and under 10 years old." [Bgee:curator] xref: EV:0300060 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000102 ! 8-year-old human stage relationship: part_of HsapDv:0000085 ! 6-12 year-old child stage [Term] id: HsapDv:0000104 name: 10-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 10 and under 11 years old." [Bgee:curator] xref: EV:0300061 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000103 ! 9-year-old human stage relationship: part_of HsapDv:0000085 ! 6-12 year-old child stage [Term] id: HsapDv:0000105 name: 11-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 11 and under 12 years old." [Bgee:curator] xref: EV:0300062 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000104 ! 10-year-old human stage relationship: part_of HsapDv:0000085 ! 6-12 year-old child stage [Term] id: HsapDv:0000106 name: 12-year-old human stage namespace: human_developmental_stage def: "Child stage that refers to a child who is over 12 and under 13 years old." [Bgee:curator] xref: EV:0300063 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000105 ! 11-year-old human stage relationship: part_of HsapDv:0000085 ! 6-12 year-old child stage [Term] id: HsapDv:0000107 name: 13-year-old human stage namespace: human_developmental_stage def: "Adolescent stage that refers to an adolescent who is over 13 and under 14 years old." [Bgee:curator] xref: EV:0300065 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000106 ! 12-year-old human stage relationship: part_of HsapDv:0000086 ! adolescent stage [Term] id: HsapDv:0000108 name: 14-year-old human stage namespace: human_developmental_stage def: "Adolescent stage that refers to an adolescent who is over 14 and under 15 years old." [Bgee:curator] xref: EV:0300066 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000107 ! 13-year-old human stage relationship: part_of HsapDv:0000086 ! adolescent stage [Term] id: HsapDv:0000109 name: 15-year-old human stage namespace: human_developmental_stage def: "Adolescent stage that refers to an adolescent who is over 15 and under 16 years old." [Bgee:curator] xref: EV:0300067 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000108 ! 14-year-old human stage relationship: part_of HsapDv:0000086 ! adolescent stage [Term] id: HsapDv:0000110 name: 16-year-old human stage namespace: human_developmental_stage def: "Adolescent stage that refers to an adolescent who is over 16 and under 17 years old." [Bgee:curator] xref: EV:0300068 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000109 ! 15-year-old human stage relationship: part_of HsapDv:0000086 ! adolescent stage [Term] id: HsapDv:0000111 name: 17-year-old human stage namespace: human_developmental_stage def: "Adolescent stage that refers to an adolescent who is over 17 and under 18 years old." [Bgee:curator] xref: EV:0300069 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000110 ! 16-year-old human stage relationship: part_of HsapDv:0000086 ! adolescent stage [Term] id: HsapDv:0000112 name: 18-year-old human stage namespace: human_developmental_stage def: "Adolescent stage that refers to an adolescent who is over 18 and under 19 years old." [Bgee:curator] xref: EV:0300071 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000111 ! 17-year-old human stage relationship: part_of HsapDv:0000086 ! adolescent stage [Term] id: HsapDv:0000113 name: 19-year-old human stage namespace: human_developmental_stage def: "Young adult stage that refers to an adult who is under 20." [Bgee:curator] xref: EV:0300072 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000112 ! 18-year-old human stage relationship: part_of HsapDv:0000089 ! young adult stage [Term] id: HsapDv:0000114 name: 20-year-old human stage namespace: human_developmental_stage def: "Young adult stage that refers to an adult who is over 20 and under 21." [Bgee:curator] xref: EV:0300073 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000113 ! 19-year-old human stage relationship: part_of HsapDv:0000089 ! young adult stage [Term] id: HsapDv:0000115 name: 21-year-old human stage namespace: human_developmental_stage def: "Young adult stage that refers to an adult who is over 21 and under 22." [Bgee:curator] xref: EV:0300074 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000114 ! 20-year-old human stage relationship: part_of HsapDv:0000089 ! young adult stage [Term] id: HsapDv:0000116 name: 22-year-old human stage namespace: human_developmental_stage def: "Young adult stage that refers to an adult who is over 22 and under 23." [Bgee:curator] xref: EV:0300075 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000115 ! 21-year-old human stage relationship: part_of HsapDv:0000089 ! young adult stage [Term] id: HsapDv:0000117 name: 23-year-old human stage namespace: human_developmental_stage def: "Young adult stage that refers to an adult who is over 23 and under 24." [Bgee:curator] xref: EV:0300076 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000116 ! 22-year-old human stage relationship: part_of HsapDv:0000089 ! young adult stage [Term] id: HsapDv:0000118 name: 24-year-old human stage namespace: human_developmental_stage def: "Young adult stage that refers to an adult who is over 24 and under 25." [Bgee:curator] xref: EV:0300077 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000117 ! 23-year-old human stage relationship: part_of HsapDv:0000089 ! young adult stage [Term] id: HsapDv:0000119 name: 25-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 25 and under 26." [Bgee:curator] xref: EV:0300078 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000118 ! 24-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000120 name: 26-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adultwho is over 26 and under 27." [Bgee:curator] xref: EV:0300079 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000119 ! 25-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000121 name: 27-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 27 and under 28." [Bgee:curator] xref: EV:0300080 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000120 ! 26-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000122 name: 28-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 28 and under 29." [Bgee:curator] xref: EV:0300081 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000121 ! 27-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000123 name: 29-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 29 and under 30." [Bgee:curator] xref: EV:0300082 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000122 ! 28-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000124 name: 30-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 30 and under 31." [Bgee:curator] xref: EV:0300083 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000123 ! 29-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000125 name: 31-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 31 and under 32." [Bgee:curator] xref: EV:0300084 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000124 ! 30-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000126 name: 32-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 32 and under 33." [Bgee:curator] xref: EV:0300085 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000125 ! 31-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000127 name: 33-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 33 and under 34." [Bgee:curator] xref: EV:0300086 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000126 ! 32-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000128 name: 34-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 34 and under 35." [Bgee:curator] xref: EV:0300087 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000127 ! 33-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000129 name: 35-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 35 and under 36." [Bgee:curator] xref: EV:0300088 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000128 ! 34-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000130 name: 36-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 36 and under 37." [Bgee:curator] xref: EV:0300089 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000129 ! 35-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000131 name: 37-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 37 and under 38." [Bgee:curator] xref: EV:0300090 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000130 ! 36-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000132 name: 38-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 38 and under 39." [Bgee:curator] xref: EV:0300091 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000131 ! 37-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000133 name: 39-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 39 and under 40." [Bgee:curator] xref: EV:0300092 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000132 ! 38-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000134 name: 40-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 40 and under 41." [Bgee:curator] xref: EV:0300093 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000133 ! 39-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000135 name: 41-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 41 and under 42." [Bgee:curator] xref: EV:0300094 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000134 ! 40-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000136 name: 42-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 42 and under 43." [Bgee:curator] xref: EV:0300095 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000135 ! 41-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000137 name: 43-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 43 and under 44." [Bgee:curator] xref: EV:0300096 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000136 ! 42-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000138 name: 44-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 44 and under 45." [Bgee:curator] xref: EV:0300097 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000137 ! 43-year-old human stage relationship: part_of HsapDv:0000090 ! 25-44 year-old human stage [Term] id: HsapDv:0000139 name: 45-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 45 and under 46." [Bgee:curator] xref: EV:0300098 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000138 ! 44-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000140 name: 46-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 46 and under 47." [Bgee:curator] xref: EV:0300099 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000139 ! 45-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000141 name: 47-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 47 and under 48." [Bgee:curator] xref: EV:0300100 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000140 ! 46-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000142 name: 48-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 48 and under 49." [Bgee:curator] xref: EV:0300101 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000141 ! 47-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000143 name: 49-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 49 and under 50." [Bgee:curator] xref: EV:0300102 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000142 ! 48-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000144 name: 50-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 50 and under 51." [Bgee:curator] xref: EV:0300103 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000143 ! 49-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000145 name: 51-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 51 and under 52." [Bgee:curator] xref: EV:0300104 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000144 ! 50-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000146 name: 52-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 52 and under 53." [Bgee:curator] xref: EV:0300105 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000145 ! 51-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000147 name: 53-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 53 and under 54." [Bgee:curator] xref: EV:0300106 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000146 ! 52-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000148 name: 54-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 54 and under 55." [Bgee:curator] xref: EV:0300107 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000147 ! 53-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000149 name: 55-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 55 and under 56." [Bgee:curator] xref: EV:0300108 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000148 ! 54-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000150 name: 56-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 56 and under 57." [Bgee:curator] xref: EV:0300109 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000149 ! 55-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000151 name: 57-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 57 and under 58." [Bgee:curator] xref: EV:0300110 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000150 ! 56-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000152 name: 58-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 58 and under 59." [Bgee:curator] xref: EV:0300111 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000151 ! 57-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000153 name: 59-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 59 and under 60." [Bgee:curator] xref: EV:0300112 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000152 ! 58-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000154 name: 60-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 60 and under 61." [Bgee:curator] xref: EV:0300113 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000153 ! 59-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000155 name: 61-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 61 and under 62." [Bgee:curator] xref: EV:0300114 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000154 ! 60-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000156 name: 62-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 62 and under 63." [Bgee:curator] xref: EV:0300115 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000155 ! 61-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000157 name: 63-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 63 and under 64." [Bgee:curator] xref: EV:0300116 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000156 ! 62-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000158 name: 64-year-old human stage namespace: human_developmental_stage def: "Middle aged stage that refers to an adult who is over 64 and under 65." [Bgee:curator] xref: EV:0300117 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000157 ! 63-year-old human stage relationship: part_of HsapDv:0000092 ! human middle aged stage [Term] id: HsapDv:0000159 name: 65-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 65 and under 66." [Bgee:curator] xref: EV:0300118 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000158 ! 64-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000160 name: 66-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 66 and under 67." [Bgee:curator] xref: EV:0300119 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000159 ! 65-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000161 name: 67-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 67 and under 68." [Bgee:curator] xref: EV:0300120 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000160 ! 66-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000162 name: 68-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 68 and under 69." [Bgee:curator] xref: EV:0300121 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000161 ! 67-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000163 name: 69-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 69 and under 70." [Bgee:curator] xref: EV:0300122 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000162 ! 68-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000164 name: 70-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 70 and under 71." [Bgee:curator] xref: EV:0300124 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000163 ! 69-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000165 name: 71-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 71 and under 72." [Bgee:curator] xref: EV:0300125 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000164 ! 70-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000166 name: 72-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 72 and under 73." [Bgee:curator] xref: EV:0300126 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000165 ! 71-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000167 name: 73-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 73 and under 74." [Bgee:curator] xref: EV:0300127 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000166 ! 72-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000168 name: 74-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 74 and under 75." [Bgee:curator] xref: EV:0300128 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000167 ! 73-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000169 name: 75-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 75 and under 76." [Bgee:curator] xref: EV:0300129 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000168 ! 74-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000170 name: 76-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 76 and under 77." [Bgee:curator] xref: EV:0300130 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000169 ! 75-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000171 name: 77-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 77 and under 78." [Bgee:curator] xref: EV:0300131 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000170 ! 76-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000172 name: 78-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 78 and under 79." [Bgee:curator] xref: EV:0300132 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000171 ! 77-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000173 name: 79-year-old human stage namespace: human_developmental_stage def: "Adult stage that refers to an adult who is over 79 and under 80." [Bgee:curator] xref: EV:0300133 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000172 ! 78-year-old human stage relationship: part_of HsapDv:0000094 ! 65-79 year-old human stage [Term] id: HsapDv:0000174 name: 1 month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 1 and under 2 months old." [Bgee:curator] xref: EV:0300039 is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000175 name: 2-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 2 and under 3 months old." [Bgee:curator] xref: EV:0300040 is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000176 name: 3-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 3 and under 4 months old." [Bgee:curator] xref: EV:0300041 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000175 ! 2-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000177 name: 4-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 4 and under 5 months old." [Bgee:curator] xref: EV:0300042 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000176 ! 3-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000178 name: 5-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 5 and under 6 months old." [Bgee:curator] xref: EV:0300043 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000177 ! 4-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000179 name: 6-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 6 and under 7 months old." [Bgee:curator] xref: EV:0300044 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000178 ! 5-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000180 name: 7-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 7 and under 8 months old." [Bgee:curator] xref: EV:0300045 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000179 ! 6-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000181 name: 8-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 8 and under 9 months old." [Bgee:curator] xref: EV:0300046 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000180 ! 7-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000182 name: 9-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 9 and under 10 months old." [Bgee:curator] xref: EV:0300047 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000181 ! 8-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000183 name: 10-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 10 and under 11 months old." [Bgee:curator] xref: EV:0300048 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000182 ! 9-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000184 name: 11-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 11 and under 12 months old." [Bgee:curator] xref: EV:0300049 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000183 ! 10-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000185 name: 12-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 12 and under 13 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000184 ! 11-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000186 name: 13-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 13 and under 14 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000185 ! 12-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000187 name: 14-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 14 and under 15 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000186 ! 13-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000188 name: 15-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 15 and under 16 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000187 ! 14-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000189 name: 16-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 16 and under 17 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000188 ! 15-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000190 name: 17-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 17 and under 18 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000189 ! 16-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000191 name: 18-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 18 and under 19 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000190 ! 17-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000192 name: 19-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 19 and under 20 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000191 ! 18-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000193 name: 20-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 20 and under 21 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000192 ! 19-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000194 name: 21-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 21 and under 22 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000193 ! 20-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000195 name: 22-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 22 and under 23 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000194 ! 21-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000196 name: 23-month-old human stage namespace: human_developmental_stage def: "Infant stage that refers to an infant who is over 23 and under 24 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by HsapDv:0000195 ! 22-month-old human stage relationship: part_of UBERON:0007221 ! neonate stage [Term] id: HsapDv:0000197 name: third LMP month human stage namespace: human_developmental_stage def: "Fetal stage that refers to the third month of gestation starting from the last menstrual period (LMP)." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000037 ! fetal stage [Term] id: HsapDv:0000198 name: fourth LMP month human stage namespace: human_developmental_stage def: "Fetal stage that refers to the fourth month of gestation starting from the last menstrual period (LMP)." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000037 ! fetal stage [Term] id: HsapDv:0000199 name: fifth LMP month human stage namespace: human_developmental_stage def: "Fetal stage that refers to the fifth month of gestation starting from the last menstrual period (LMP)." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000037 ! fetal stage [Term] id: HsapDv:0000200 name: sixth LMP month human stage namespace: human_developmental_stage def: "Fetal stage that refers to the sixth month of gestation starting from the last menstrual period (LMP)." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000037 ! fetal stage [Term] id: HsapDv:0000201 name: seventh LMP month human stage namespace: human_developmental_stage def: "Fetal stage that refers to the seventh month of gestation starting from the last menstrual period (LMP)." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000037 ! fetal stage [Term] id: HsapDv:0000202 name: eighth LMP month human stage namespace: human_developmental_stage def: "Fetal stage that refers to the eighth month of gestation starting from the last menstrual period (LMP)." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000037 ! fetal stage [Term] id: HsapDv:0000203 name: ninth LMP month human stage namespace: human_developmental_stage def: "Fetal stage that refers to the ninth month of gestation starting from the last menstrual period (LMP)." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000037 ! fetal stage [Term] id: HsapDv:0000204 name: mature stage namespace: human_developmental_stage def: "Human developmental stage that refers to a sexually mature human." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of HsapDv:0000001 ! human life cycle [Term] id: MmusDv:0000003 name: Theiler stage 01 namespace: mouse_developmental_stage def: "Embryonic stage defined by a one-cell embryo (fertilised egg) with zona pellucida present." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_1] comment: Starts the mouse development sequence, range from embryonic age 0-0.9 dpc (day post-coitum). synonym: "TS01 (E0-2.5)" RELATED [EMAPA:TS01] synonym: "zygote stage" RELATED [] xref: TS01 xref: XUO:0000045 is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0000068 ! embryo stage [Term] id: MmusDv:0000005 name: Theiler stage 02 namespace: mouse_developmental_stage def: "Embryonic cleavage stage defined by a dividing 2-4 cells egg." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_2] comment: Embryonic age 1 dpc (day post-coitum). synonym: "TS02 (E1-2.5)" RELATED [EMAPA:TS02] xref: TS02 xref: XUO:0000046 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000003 ! Theiler stage 01 relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: MmusDv:0000006 name: Theiler stage 03 namespace: mouse_developmental_stage def: "Embryonic cleavage stage defined by a dividing 4-16 cells egg, early to fully compacted morula." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_3] comment: Embryonic age 2 dpc (day post-coitum). synonym: "TS03 (E1-3.5)" RELATED [EMAPA:TS03] xref: TS03 xref: XUO:0000047 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000005 ! Theiler stage 02 relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: MmusDv:0000008 name: Theiler stage 04 namespace: mouse_developmental_stage def: "Embryonic blastula stage defined by a dividing 16-40 cells egg, with early evidence of the blastocoelic cavity." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_4] comment: Embryonic age 3 dpc (day post-coitum). synonym: "TS04 (E2-4)" RELATED [EMAPA:TS04] xref: TS04 xref: XUO:0000048 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000006 ! Theiler stage 03 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: MmusDv:0000009 name: Theiler stage 05 namespace: mouse_developmental_stage def: "Embryonic blastula stage defined by a zona free blastocyst (zona pellucida absent)." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_5] comment: Embryonic age 4 dpc (day post-coitum). synonym: "TS05 (E3-5.5)" RELATED [EMAPA:TS05] xref: TS05 xref: XUO:0000049 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000008 ! Theiler stage 04 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: MmusDv:0000010 name: Theiler stage 06 namespace: mouse_developmental_stage def: "Embryonic blastula stage during which the blastocyst attaches, with first evidence of embryonic endoderm cells covering the blastocoelic surface of the inner cell mass." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_6] comment: Embryonic age 4.5 dpc (day post-coitum). Refers to human CarnegieStage04. synonym: "TS06 (E4-5.5)" RELATED [EMAPA:TS06] xref: TS06 xref: XUO:0000050 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000009 ! Theiler stage 05 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: MmusDv:0000011 name: Theiler stage 07 namespace: mouse_developmental_stage def: "Embryonic blastula stage defined by implantation and formation of the egg cylinder resulting from the rapid increase in the number of inner cell mass cells." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_7] comment: Embryonic age 5 dpc (day post-coitum). Refers to human CarnegieStage05. synonym: "TS07 (E4.5-6)" RELATED [EMAPA:TS07] xref: TS07 xref: XUO:0000051 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000010 ! Theiler stage 06 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: MmusDv:0000012 name: Theiler stage 08 namespace: mouse_developmental_stage def: "Embryonic blastula stage during which the egg cylinder differentiates into embryonic and extra-embryonic regions, and the pro-amniotic cavity appears." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_8] comment: Embryonic age 6 dpc (day post-coitum). Refers to human CarnegieStage05. synonym: "TS08 (E5-6.5)" RELATED [EMAPA:TS08] xref: TS08 xref: XUO:0000052 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000011 ! Theiler stage 07 relationship: part_of UBERON:0000108 ! blastula stage [Term] id: MmusDv:0000014 name: Theiler stage 09 namespace: mouse_developmental_stage def: "Embryonic gastrula stage during which gastrulation starts with first evidence of mesoderm and visible embryonic axis." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_9] comment: Embryonic age 6.5 dpc (day post-coitum). synonym: "TS09 (E6.25-7.25)" RELATED [EMAPA:TS09] xref: TS09 xref: XUO:0000053 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000012 ! Theiler stage 08 relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: MmusDv:0000015 name: Theiler stage 10 namespace: mouse_developmental_stage def: "Embryonic gastrula stage during which the primitive streak bulges into the pro-amniotic cavity and forms the amniotic fold; the exocoelom appears; the allantoic bud first appears, gastrulation continues and the node becomes visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_10] comment: Embryonic age 7 dpc (day post-coitum), (range 6.5-7.5 dpc). Refers to human CarnegieStage08. synonym: "TS10 (E6.5-7.75)" RELATED [EMAPA:TS10] xref: TS10 xref: XUO:0000054 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000014 ! Theiler stage 09 relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: MmusDv:0000017 name: Theiler stage 11 namespace: mouse_developmental_stage def: "Embryonic stage called presomite stage and defined by the formation of the neural plate." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_11] comment: This stage starts the emergence of the central nervous system at embryonic age 7.5 dpc (day post-coitum). synonym: "neurula stage" RELATED [] synonym: "TS11 (E7.25-8)" RELATED [EMAPA:TS11] xref: TS11 xref: XUO:0000055 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000015 ! Theiler stage 10 relationship: part_of UBERON:0000068 ! embryo stage [Term] id: MmusDv:0000019 name: Theiler stage 12 namespace: mouse_developmental_stage def: "Organogenesis stage during which first somites become visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_12] comment: Embryonic age 8 dpc (day post-coitum). Refers to human CarnegieStage09. synonym: "TS12 (E7.5-8.75)" RELATED [EMAPA:TS12] xref: TS12 xref: XUO:0000056 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000017 ! Theiler stage 11 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000020 name: Theiler stage 13 namespace: mouse_developmental_stage def: "Organogenesis stage defined by the turning of the embryo; initiated in embryos with 6-8 pairs of somites and usually completed in embryos with 14-16 pairs of somites." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_13] comment: Embryonic age 8.5 dpc (day post-coitum). Refers to human CarnegieStage10. synonym: "TS13 (E8-9.25)" RELATED [EMAPA:TS13] xref: TS13 xref: XUO:0000057 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000019 ! Theiler stage 12 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000021 name: Theiler stage 14 namespace: mouse_developmental_stage def: "Organogenesis stage during which the rostral extremity of the neural tube closes in embryos with usually about 15-18 somite pairs. Late in the stage the 3rd branchial arch becomes visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_14] comment: Embryonic age 9 dpc (day post-coitum). Refers to human CarnegieStage11. synonym: "TS14 (E8.5-9.75)" RELATED [EMAPA:TS14] xref: TS14 xref: XUO:0000058 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000020 ! Theiler stage 13 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000022 name: Theiler stage 15 namespace: mouse_developmental_stage def: "Organogenesis stage during which the posterior neuropore forms and the condensation of the forelimb bud becomes apparent near the 8th-12th somite pairs." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_15] comment: Embryonic age 9.5 dpc (day post-coitum). Refers to human CarnegieStage12. synonym: "TS15 (E9-10.25)" RELATED [EMAPA:TS15] xref: TS15 xref: XUO:0000059 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000021 ! Theiler stage 14 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000023 name: Theiler stage 16 namespace: mouse_developmental_stage def: "Organogenesis stage during which the posterior neuropore closes and the hind limb bud becomes visible at the level of the 23rd-28th somites." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_16] comment: Embryonic age 10 dpc (day post-coitum). Refers to human CarnegieStages 13 to 15. synonym: "TS16 (E9.5-10.75)" RELATED [EMAPA:TS16] xref: TS16 xref: XUO:0000060 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000022 ! Theiler stage 15 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000024 name: Theiler stage 17 namespace: mouse_developmental_stage def: "Organogenesis stage defined by the deepening of the lens pit and the first appearance of the physiological umbilical hernia." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_17] comment: Embryonic age 10.5 dpc (day post-coitum). Refers to human CarnegieStages 13 to 15. synonym: "TS17 (E10-11.25)" RELATED [EMAPA:TS17] xref: TS17 xref: XUO:0000061 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000023 ! Theiler stage 16 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000025 name: Theiler stage 18 namespace: mouse_developmental_stage def: "Organogenesis stage during which the lens vesicle gradually closes and the nasal pits start to form. The rapid growth of the brain is striking." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_18] comment: Embryonic age 11 dpc (day post-coitum). Refers to human CarnegieStages 13 to 15. synonym: "TS18 (E10.5-11.25)" RELATED [EMAPA:TS18] xref: TS18 xref: XUO:0000062 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000024 ! Theiler stage 17 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000026 name: Theiler stage 19 namespace: mouse_developmental_stage def: "Organogenesis stage during which the lens vesicle becomes completely closed and detached from the ectoderm, and peripheral margins of the eye become well defined." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_19] comment: Embryonic age 11.5 dpc (day post-coitum). Refers to human CarnegieStage16. synonym: "TS19 (E11-12.25)" RELATED [EMAPA:TS19] xref: TS19 xref: XUO:0000063 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000025 ! Theiler stage 18 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000027 name: Theiler stage 20 namespace: mouse_developmental_stage def: "Organogenesis stage during which the handplate develops angles corresponding to the future digits, and tongue and brain vesicles are clearly visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_20] comment: Embryonic age 12 dpc (day post-coitum). Refers to human CarnegieStage17. synonym: "TS20 (E11.5-13)" RELATED [EMAPA:TS20] xref: TS20 xref: XUO:0000064 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000026 ! Theiler stage 19 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000028 name: Theiler stage 21 namespace: mouse_developmental_stage def: "Organogenesis stage during which the digit widths and locations can be discerned, and the pinna rapidly develops and forms a crest at right angles to the head." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_21] comment: Embryonic age 13 dpc (day post-coitum). Refers to human CarnegieStages 18 and 19. synonym: "TS21 (E12.5-14)" RELATED [EMAPA:TS21] xref: TS21 xref: XUO:0000065 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000027 ! Theiler stage 20 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000029 name: Theiler stage 22 namespace: mouse_developmental_stage def: "Organogenesis stage during which the fingers are clearly visible and the long bones of the limbs are present." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_22] comment: Embryonic age 14 dpc (day post-coitum). Refers to human CarnegieStages 20 to 23. synonym: "TS22 (E13.5-15)" RELATED [EMAPA:TS22] xref: TS22 xref: XUO:0000066 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000028 ! Theiler stage 21 relationship: part_of UBERON:0000111 ! organogenesis stage [Term] id: MmusDv:0000032 name: Theiler stage 23 namespace: mouse_developmental_stage def: "Fetal stage during which the toes separate and hair follicles are present in the cephalic region but not at the periphery of the vibrissae." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_23] comment: Embryonic age 15 dpc (day post-coitum). Refers to the human fetal period. synonym: "TS23 (E15)" RELATED [EMAPA:TS23] xref: TS23 xref: XUO:0000067 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000029 ! Theiler stage 22 relationship: part_of UBERON:0007220 ! late embryonic stage [Term] id: MmusDv:0000033 name: Theiler stage 24 namespace: mouse_developmental_stage def: "Fetal stage during which the umbilical hernia disappears and there is a corresponding increase in the size of the peritoneal sac." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_24] comment: Embryonic age 16 dpc (day post-coitum). Refers to the human fetal period. synonym: "TS24 (E16)" RELATED [EMAPA:TS24] xref: TS24 xref: XUO:0000068 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000032 ! Theiler stage 23 relationship: part_of UBERON:0007220 ! late embryonic stage [Term] id: MmusDv:0000034 name: Theiler stage 25 namespace: mouse_developmental_stage def: "Fetal stage during which the thickened skin forms wrinkles and the subcutaneous veins are less visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_25] comment: Embryonic age 17 dpc (day post-coitum). Refers to the human fetal period. synonym: "TS25 (E17)" RELATED [EMAPA:TS25] xref: TS25 xref: XUO:0000069 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000033 ! Theiler stage 24 relationship: part_of UBERON:0007220 ! late embryonic stage [Term] id: MmusDv:0000035 name: Theiler stage 26 namespace: mouse_developmental_stage def: "Fetal stage defined by long whiskers and during which the eyes are barely visible through the closed eyelids." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_26] comment: Embryonic age 18 dpc (day post-coitum). Refers to the human fetal period. synonym: "TS26 (E18)" RELATED [EMAPA:TS26] xref: TS26 xref: XUO:0000070 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000034 ! Theiler stage 25 relationship: part_of UBERON:0007220 ! late embryonic stage [Term] id: MmusDv:0000036 name: Theiler stage 27 namespace: mouse_developmental_stage def: "Early immature stage that refers to the newborn mouse. Description of anatomical structures related to this stage corresponds to the first day of the mouse life." [http://www.emouseatlas.org/emap/ema/theiler_stages/StageDefinition/ts27definition.html] comment: Embryonic age 19-20 dpc (day post-coitum). synonym: "newborn stage" RELATED [] synonym: "TS27" RELATED [EMAPA:TS27] xref: TS27 xref: XUO:0000071 is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000035 ! Theiler stage 26 relationship: part_of MmusDv:0000096 ! early immature stage [Term] id: MmusDv:0000041 name: unknown namespace: mouse_developmental_stage is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0000105 ! life cycle stage [Term] id: MmusDv:0000042 name: prenatal stage namespace: mouse_developmental_stage def: "mouse life cycle that starts with fertilization and ends with birth." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0000105 ! life cycle stage [Term] id: MmusDv:0000043 name: immature stage namespace: mouse_developmental_stage def: "Mouse developmental stage that covers the period from birth until 5 weeks old." [Bgee:curator] comment: The organisation of the postnatal development time in mouse is debatable, it is commonly accepted that mouse reaches sexual maturity by six weeks of age (see http://www.ahc.umn.edu/rar/breeding.html).synonym: "postnatal development" RELATED [] synonym: "P0-adult" RELATED [EMAP:TS28] synonym: "Theiler stage 28" RELATED [] synonym: "TheilerStage28" RELATED [] synonym: "TS28 (P0-Adult)" RELATED [EMAP:TS28] xref: TS28 is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0000105 ! life cycle stage [Term] id: MmusDv:0000044 name: 1-7 days namespace: mouse_developmental_stage def: "Early immature stage that refers to the newborn mouse which is over 1 and under 8 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000096 ! early immature stage [Term] id: MmusDv:0000045 name: 1 week namespace: mouse_developmental_stage def: "Infant stage that refers to a mouse which is over 7 days and under 15 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000044 ! 1-7 days relationship: part_of UBERON:0007221 ! neonate stage [Term] id: MmusDv:0000046 name: 2 weeks namespace: mouse_developmental_stage def: "Infant stage that refers to a mouse which is over 14 days and under 22 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000045 ! 1 week relationship: part_of UBERON:0007221 ! neonate stage [Term] id: MmusDv:0000047 name: 3 weeks namespace: mouse_developmental_stage def: "Infant stage that refers to a mouse which is over 21 days and under 29 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000046 ! 2 weeks relationship: part_of UBERON:0007221 ! neonate stage [Term] id: MmusDv:0000048 name: 4 weeks namespace: mouse_developmental_stage def: "Infant stage that refers to a mouse which is over 28 days and under 36 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000047 ! 3 weeks relationship: part_of UBERON:0007221 ! neonate stage [Term] id: MmusDv:0000049 name: 5 weeks namespace: mouse_developmental_stage def: "Infant stage that refers to a mouse which is over 35 days and under 43 days old." [Bgee:curator] comment: This stage is usually the stage during which the sexual maturity occurs. is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000048 ! 4 weeks relationship: part_of UBERON:0007221 ! neonate stage [Term] id: MmusDv:0000050 name: 6 weeks namespace: mouse_developmental_stage def: "Early stage that refers to a mouse which is over 42 days and under 50 days old." [Bgee:curator] comment: This stage is commonly considered in the literature as the milestone that distinguishes between sexually immmature and mature stages (see http://www.ahc.umn.edu/rar/breeding.html). is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000049 ! 5 weeks relationship: part_of MmusDv:0000061 ! early adult stage [Term] id: MmusDv:0000051 name: 7 weeks namespace: mouse_developmental_stage def: "Early adult stage that refers to a mouse which is over 49 days and under 57 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000050 ! 6 weeks relationship: part_of MmusDv:0000061 ! early adult stage [Term] id: MmusDv:0000052 name: 8 weeks namespace: mouse_developmental_stage def: "2 month-old stage that refers to a mouse which is over 56 days and under 64 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000051 ! 7 weeks relationship: part_of MmusDv:0000062 ! 2 month-old stage [Term] id: MmusDv:0000053 name: 9 weeks namespace: mouse_developmental_stage def: "2 month-old stage that refers to a mouse which is over 63 days and under 71 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000052 ! 8 weeks relationship: part_of MmusDv:0000062 ! 2 month-old stage [Term] id: MmusDv:0000054 name: 10 weeks namespace: mouse_developmental_stage def: "2 month-old stage that refers to a mouse which is over 70 days and under 78 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000053 ! 9 weeks relationship: part_of MmusDv:0000062 ! 2 month-old stage [Term] id: MmusDv:0000055 name: 11 weeks namespace: mouse_developmental_stage def: "2 month-old stage that refers to a mouse which is over 77 days and under 85 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000054 ! 10 weeks relationship: part_of MmusDv:0000062 ! 2 month-old stage [Term] id: MmusDv:0000056 name: 12 weeks namespace: mouse_developmental_stage def: "3 month-old stage that refers to a mouse which is over 84 days and under 92 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000055 ! 11 weeks relationship: part_of MmusDv:0000063 ! 3 month-old stage [Term] id: MmusDv:0000057 name: 13 weeks namespace: mouse_developmental_stage def: "3 month-old stage that refers to a mouse which is over 91 days and under 99 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000056 ! 12 weeks relationship: part_of MmusDv:0000063 ! 3 month-old stage [Term] id: MmusDv:0000058 name: 14 weeks namespace: mouse_developmental_stage def: "3 month-old stage that refers to a mouse which is over 98 days and under 106 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000057 ! 13 weeks relationship: part_of MmusDv:0000063 ! 3 month-old stage [Term] id: MmusDv:0000059 name: 15 weeks namespace: mouse_developmental_stage def: "3 month-old stage that refers to a mouse which is over 105 days and under 113 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000058 ! 14 weeks relationship: part_of MmusDv:0000063 ! 3 month-old stage [Term] id: MmusDv:0000061 name: early adult stage namespace: mouse_developmental_stage def: "Mature stage that refers to a adult mouse which is over 6 weeks and under 7 months old." [http://research.jax.org/faculty/harrison/ger1vLifespan1.html#VD] comment: Mice under 7 months of age are commonly considered as young adult in the literature, without loss of functional capability like hearing (see http://www.ncbi.nlm.nih.gov/pubmed/18259074). is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000110 ! mature stage [Term] id: MmusDv:0000062 name: 2 month-old stage namespace: mouse_developmental_stage def: "Early adult stage that refers to a mouse which is over 2 and under 3 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000061 ! early adult stage [Term] id: MmusDv:0000063 name: 3 month-old stage namespace: mouse_developmental_stage def: "Early adult stage that refers to a mouse which is over 3 and under 4 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000062 ! 2 month-old stage relationship: part_of MmusDv:0000061 ! early adult stage [Term] id: MmusDv:0000064 name: 4 month-old stage namespace: mouse_developmental_stage def: "Early adult stage that refers to a mouse which is over 4 and under 5 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000063 ! 3 month-old stage relationship: part_of MmusDv:0000061 ! early adult stage [Term] id: MmusDv:0000065 name: 16 weeks namespace: mouse_developmental_stage def: "4 month-old stage that refers to a mouse which is over 112 days and under 120 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000059 ! 15 weeks relationship: part_of MmusDv:0000064 ! 4 month-old stage [Term] id: MmusDv:0000066 name: 17 weeks namespace: mouse_developmental_stage def: "4 month-old stage that refers to a mouse which is over 119 days and under 127 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000065 ! 16 weeks relationship: part_of MmusDv:0000064 ! 4 month-old stage [Term] id: MmusDv:0000067 name: 18 weeks namespace: mouse_developmental_stage def: "4 month-old stage that refers to a mouse which is over 126 days and under 134 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000066 ! 17 weeks relationship: part_of MmusDv:0000064 ! 4 month-old stage [Term] id: MmusDv:0000068 name: 19 weeks namespace: mouse_developmental_stage def: "4 month-old stage that refers to a mouse which is over 133 days and under 141 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000067 ! 18 weeks relationship: part_of MmusDv:0000064 ! 4 month-old stage [Term] id: MmusDv:0000069 name: 5 month-old stage namespace: mouse_developmental_stage def: "Early adult stage that refers to a mouse which is over 5 and under 6 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000064 ! 4 month-old stage relationship: part_of MmusDv:0000061 ! early adult stage [Term] id: MmusDv:0000070 name: 20 weeks namespace: mouse_developmental_stage def: "4 month-old stage that refers to a mouse which is over 140 days and under 148 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000068 ! 19 weeks relationship: part_of MmusDv:0000064 ! 4 month-old stage [Term] id: MmusDv:0000071 name: 21 weeks namespace: mouse_developmental_stage def: "5 month-old stage that refers to a mouse which is over 147 days and under 155 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000070 ! 20 weeks relationship: part_of MmusDv:0000069 ! 5 month-old stage [Term] id: MmusDv:0000072 name: 22 weeks namespace: mouse_developmental_stage def: "5 month-old stage that refers to a mouse which is over 154 days and under 162 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000071 ! 21 weeks relationship: part_of MmusDv:0000069 ! 5 month-old stage [Term] id: MmusDv:0000073 name: 23 weeks namespace: mouse_developmental_stage def: "5 month-old stage that refers to a mouse which is over 161 days and under 169 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000072 ! 22 weeks relationship: part_of MmusDv:0000069 ! 5 month-old stage [Term] id: MmusDv:0000074 name: 24 weeks namespace: mouse_developmental_stage def: "5 month-old stage that refers to a mouse which is over 168 days and under 176 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000073 ! 23 weeks relationship: part_of MmusDv:0000069 ! 5 month-old stage [Term] id: MmusDv:0000075 name: middle aged stage namespace: mouse_developmental_stage def: "Late adult stage that refers to a mouse which is over 7 and under 15 months old." [http://research.jax.org/faculty/harrison/ger1vLifespan1.html#VD] comment: This stage is commonly considered in the literature as the stage during which first evidence of loss of functional capability like hearing occurs in wild type mouse strain (see http://www.ncbi.nlm.nih.gov/pubmed/18259074). is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000097 ! late adult stage [Term] id: MmusDv:0000076 name: aged adult stage namespace: mouse_developmental_stage def: "Late adult stage that refers to a mouse which is over 15 months old." [http://research.jax.org/faculty/harrison/ger1vLifespan1.html#VD] is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000097 ! late adult stage [Term] id: MmusDv:0000077 name: 6 month-old stage namespace: mouse_developmental_stage def: "Early adult stage that refers to a mouse which is over 6 and under 7 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000069 ! 5 month-old stage relationship: part_of MmusDv:0000061 ! early adult stage [Term] id: MmusDv:0000078 name: 7 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 7 and under 8 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000077 ! 6 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000079 name: 8 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 8 and under 9 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000078 ! 7 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000080 name: 9 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 9 and under 10 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000079 ! 8 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000081 name: 10 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 10 and under 11 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000080 ! 9 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000082 name: 11 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 11 and under 12 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000081 ! 10 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000083 name: 12 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 12 and under 13 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000082 ! 11 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000084 name: 13 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 13 and under 14 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000083 ! 12 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000085 name: 14 month-old stage namespace: mouse_developmental_stage def: "Middle aged stage that refers to a mouse which is over 14 and under 15 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000084 ! 13 month-old stage relationship: part_of MmusDv:0000075 ! middle aged stage [Term] id: MmusDv:0000086 name: 15 month-old stage namespace: mouse_developmental_stage def: "Aged adult stage that refers to a mouse which is over 15 and under 16 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000085 ! 14 month-old stage relationship: part_of MmusDv:0000076 ! aged adult stage [Term] id: MmusDv:0000087 name: 16 month-old stage namespace: mouse_developmental_stage def: "Aged adult stage that refers to a mouse which is over 16 and under 17 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000086 ! 15 month-old stage relationship: part_of MmusDv:0000076 ! aged adult stage [Term] id: MmusDv:0000088 name: 17 month-old stage namespace: mouse_developmental_stage def: "Aged adult stage that refers to a mouse which is over 17 and under 18 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000087 ! 16 month-old stage relationship: part_of MmusDv:0000076 ! aged adult stage [Term] id: MmusDv:0000089 name: 18 month-old stage namespace: mouse_developmental_stage def: "Aged adult stage that refers to a mouse which is over 18 and under 19 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000088 ! 17 month-old stage relationship: part_of MmusDv:0000076 ! aged adult stage [Term] id: MmusDv:0000090 name: 19 month-old stage namespace: mouse_developmental_stage def: "Aged adult stage that refers to a mouse which is over 19 and under 20 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000089 ! 18 month-old stage relationship: part_of MmusDv:0000076 ! aged adult stage [Term] id: MmusDv:0000091 name: 20 month-old stage and over namespace: mouse_developmental_stage def: "Aged adult stage that refers to a mouse which is over 20 months old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000076 ! aged adult stage [Term] id: MmusDv:0000092 name: Theiler stage 11a namespace: mouse_developmental_stage def: "Embryonic neurula stage during which the neural plate formation occurs and the amniotic cavity is sealed off into three distinct cavities - the amniotic cavity, the exocoelom and the ectoplacental cleft." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_11] is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000017 ! Theiler stage 11 [Term] id: MmusDv:0000093 name: Theiler stage 11b namespace: mouse_developmental_stage def: "Embryonic neurula stage during which the neural plate formation occurs and the allantoic bud elongates ." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_11] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000092 ! Theiler stage 11a relationship: part_of MmusDv:0000017 ! Theiler stage 11 [Term] id: MmusDv:0000094 name: Theiler stage 11c namespace: mouse_developmental_stage def: "Embryonic neurula stage during which the neural plate formation occurs and the head folds are formed while the neural groove becomes visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_11] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000093 ! Theiler stage 11b relationship: part_of MmusDv:0000017 ! Theiler stage 11 [Term] id: MmusDv:0000095 name: Theiler stage 11d namespace: mouse_developmental_stage def: "Embryonic neurula stage during which the neural plate formation occurs and the head folds continue to enlarge while the foregut pocket begins to form." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_11] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000094 ! Theiler stage 11c relationship: part_of MmusDv:0000017 ! Theiler stage 11 [Term] id: MmusDv:0000096 name: early immature stage namespace: mouse_developmental_stage def: "Immature stage that covers the period from birth until end of the first week." [Bgee:curator] comment: This stage groups the first seven days of the mouse life as described in K.Theiler's book, The House Mouse, Atlas of Embryonic Development, Springer-Verlag (second printing 1989). is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000043 ! immature stage [Term] id: MmusDv:0000097 name: late adult stage namespace: mouse_developmental_stage def: "Mature stage that refers to an adult mouse which is over 7 months old." [http://research.jax.org/faculty/harrison/ger1vLifespan1.html#VD] is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000110 ! mature stage [Term] id: MmusDv:0000098 name: 25 weeks namespace: mouse_developmental_stage def: "6 month-old stage that refers to a mouse which is over 175 days and under 183 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000074 ! 24 weeks relationship: part_of MmusDv:0000077 ! 6 month-old stage [Term] id: MmusDv:0000099 name: 26 weeks namespace: mouse_developmental_stage def: "6 month-old stage that refers to a mouse which is over 182 days and under 190 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000098 ! 25 weeks relationship: part_of MmusDv:0000077 ! 6 month-old stage [Term] id: MmusDv:0000100 name: 27 weeks namespace: mouse_developmental_stage def: "6 month-old stage that refers to a mouse which is over 189 days and under 197 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000099 ! 26 weeks relationship: part_of MmusDv:0000077 ! 6 month-old stage [Term] id: MmusDv:0000101 name: 28 weeks namespace: mouse_developmental_stage def: "6 month-old stage that refers to a mouse which is over 196 days and under 204 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000100 ! 27 weeks relationship: part_of MmusDv:0000077 ! 6 month-old stage [Term] id: MmusDv:0000102 name: 29 weeks namespace: mouse_developmental_stage def: "6 month-old stage that refers to a mouse which is over 203 days and under 211 days old." [Bgee:curator] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000101 ! 28 weeks relationship: part_of MmusDv:0000077 ! 6 month-old stage [Term] id: MmusDv:0000103 name: Theiler stage 09a namespace: mouse_developmental_stage def: "Theiler developmental stage 9 defined by advanced endometrial reaction and during which the egg-cylinder stage advances with the first evidence of an embryonic axis." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Stage_9a] is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000014 ! Theiler stage 09 [Term] id: MmusDv:0000104 name: Theiler stage 09b namespace: mouse_developmental_stage def: "Theiler developmental stage 9 defined by advanced endometrial reaction and during which the first mesodermal cells are produced by gastrulation late in this stage." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Stage_9b] is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000103 ! Theiler stage 09a relationship: part_of MmusDv:0000014 ! Theiler stage 09 [Term] id: MmusDv:0000105 name: Theiler stage 10a namespace: mouse_developmental_stage def: "Theiler developmental stage 10 during which the tissue at the posterior end of the primitive streak bulges into the pro-amniotic cavity and forms the amniotic fold." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Stage_10a] comment: Refers to MS (mid-streak) stage in Downs and Davies staging of gastrulating mouse embryos (PMID: 8269852, 1993). is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000015 ! Theiler stage 10 [Term] id: MmusDv:0000106 name: Theiler stage 10b namespace: mouse_developmental_stage def: "Theiler developmental stage 10 during which small cavities coalesce to form a single cavity in the mesoderm of the posterior amniotic fold, the exocoelom." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_10b] comment: Refers to MS-LS (mid-streak to late streak) stage in Downs and Davies staging of gastrulating mouse embryos, 1993 (see http://www.ncbi.nlm.nih.gov/pubmed/8269852). is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000105 ! Theiler stage 10a relationship: part_of MmusDv:0000015 ! Theiler stage 10 [Term] id: MmusDv:0000107 name: Theiler stage 10c namespace: mouse_developmental_stage def: "Theiler developmental stage 10 during which the allantoic bud first appears, gastrulation continues and the node becomes visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_10c] comment: Refers to MS-LS (mid-streak to late streak) stage in Downs and Davies staging of gastrulating mouse embryos, 1993 (see http://www.ncbi.nlm.nih.gov/pubmed/8269852). is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000106 ! Theiler stage 10b relationship: part_of MmusDv:0000015 ! Theiler stage 10 [Term] id: MmusDv:0000108 name: Theiler stage 12a namespace: mouse_developmental_stage def: "Theiler developmental stage 12 defined by unturned embryo with first appearance of somite pairs 1-4 and during which the allantois extends further into the exocoelom. Maxillary components of the 1st branchial arch become prominent. The preotic sulcus is visible in the 2-3 somite embryo. The cardiogenic plate begins to form and the foregut pocket is clearly visible." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_12a] comment: Embryonic age 8 dpc (day post-coitum). Refers to human CarnegieStage09. is_a: UBERON:0000104 ! life cycle relationship: part_of MmusDv:0000019 ! Theiler stage 12 [Term] id: MmusDv:0000109 name: Theiler stage 12b namespace: mouse_developmental_stage def: "Theiler developmental stage 12 defined by unturned embryo with first appearance of somite pairs 5-7 and during which neural closure occurs in the region of the 4th and 5th somites, extending in both directions from this site. Headfolds are particularly prominent. Optic placodes are first evident and become indented to form the optic pits. The heart rudiment develops rapidly. The allantois contacts the chorion at the end of this stage." [http://php.med.unsw.edu.au/embryology/index.php?title=Mouse_Stages#Theiler_Stage_12b] comment: Embryonic age 8 dpc (day post-coitum). Refers to human CarnegieStage09. is_a: UBERON:0000104 ! life cycle relationship: immediately_preceded_by MmusDv:0000108 ! Theiler stage 12a relationship: part_of MmusDv:0000019 ! Theiler stage 12 [Term] id: MmusDv:0000110 name: mature stage namespace: mouse_developmental_stage def: "Mouse developmental stage that refers to a sexually mature adult mouse which is over 6 weeks old." [Bgee:curator] synonym: "mature" EXACT [] is_a: UBERON:0000104 ! life cycle relationship: part_of UBERON:0000105 ! life cycle stage [Term] id: OlatDv:0000020 name: Medaka stage 0 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - Stage 0 Unfertilized eggs: The mature unfertilized egg is an oblate spheroid measuring average 1,245.9 +/-3.9 um (n=122) in horizontal diameter and a little less (average 1,169.9 +/- 4.0 um, n=122) in vertical diameter. The egg proper is closely surrounded by a thick egg envelope, the chorion. The perivitelline space between the chorion and the vitellus is very difficult to recognize using a light microscope. The micropyle located in the chorion at the animal pole is a small trumpet- or funnel-like structure. A number of short villi (non-attaching filaments; average 200.3 +/- 4.7 / egg, n=38) are distributed over the whole surface of the chorion. At spawning, eggs are held together in clumps by a tuft of long attaching filaments (average 29.6 +/- 1.3 / egg, n=38) on the chorion surface in the vegetal pole area of each egg [13]. A large, transparent yolk sphere is located in the center of each unfertilized egg. The cortical alveoli (vesicles, ca. 0.4-45 um in diameter) and oil droplets are embedded at random in the cortical cytoplasm. The cortical alveoli contain a transparent colloidal material and usually one or sometimes a few spherical bodies [16]. The size of the oil droplets usually varies according to differences in the temperature during and after oocyte maturation, in the time after ovulation and among the individual females. - " [OlatDv:curators] synonym: "unfertilized eggs" EXACT [] is_a: UBERON:0000105 ! life cycle stage [Term] id: OlatDv:0000030 name: Medaka stage 1 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 3 min Stage 1 (3 min) Activated egg stage: When an egg is stimulated by a spermatozoon arriving at the vitelline surface through the micropyle, a transient wave of increase in cytoplasmic free calcium starts at the point of sperm attachment [5,33]. The cortical alveoli in the vicinity of the micropyle also begin to break down (exocytosis of alveolar contents) about 9 sec after sperm attachment [17]. The wave of exocytosis begins to propagate over the whole egg surface and ends at the vegetal pole 154 sec after its beginning. As a result of the exocytosis of cortical alveoli into the narrow space between the chorion and the vitellus, the chorion thins and hardens [24] as it separates from the vitellus to form a wide perivitelline space. Swollen spherical bodies secreted from the cortical alveoli are faintly visible in the perivitelline space. A transient \"contractile wave\" of cortical cytoplasmic layer follows the wave of exocytosis [9,15]. Due to the oscillatory contractions following this distinct contractile wave, the cortical cytoplasm progressively accumulates toward the animal pole to form a thick cytoplasmic layer [1,26]. At 7-8 minutes after sperm entry, the second polar body is extruded onto the surface of the cytoplasm at the center of the area where the germinal vesicle broke down during oocyte maturation. - 3 min " [OlatDv:curators] synonym: "activated egg stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000020 ! Medaka stage 0 [Term] id: OlatDv:0000040 name: Medaka stage 2a namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 30 min Stage 2a (30 min) Blastodisc stage a: The male and the female pronuclei migrate toward and associate with each other at the center of the thick cytoplasmic disc at the animal pole. Chromosomes then appear and divide into two groups at the poles of the spindle marking the end of this stage. Oscillatory contractions cause the peripheral cortical cytoplasm to migrate toward the animal pole where it forms a convex, lens-shaped blastodisc. Meanwhile, oil droplets migrate toward the vegetal pole and begin coalescing. - 30 min " [OlatDv:curators] synonym: "blastodisc stage a" EXACT [] is_a: UBERON:0000105 ! life cycle stage [Term] id: OlatDv:0000050 name: Medaka stage 2b namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 60 min Stage 2b (60 min) Blastodisc stage b: The male and the female pronuclei migrate toward and associate with each other at the center of the thick cytoplasmic disc at the animal pole. Chromosomes then appear and divide into two groups at the poles of the spindle marking the end of this stage. The layer of cortical cytoplasm covering the yolk sphere is very thin except where it forms the cap-shaped blastodisc. By the end of this stage, most of the oil droplets from the animal hemisphere have already migrated to the vegetal hemisphere. Two dimple-like pits on the blastodisc serve as markers to locate the future blastomeres. - 60 min " [OlatDv:curators] synonym: "blastodisc stage b" EXACT [] is_a: UBERON:0000105 ! life cycle stage [Term] id: OlatDv:0000060 name: Medaka stage 3 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 hr 5 min Stage 3 (1 hr 5 min) 2 cell stage: The first cleavage plane is at a right angle to the axis between the second polar body (meiotic spindle) and the micropyle in 60-79% of eggs. The two blastomeres are highly rounded just after cleavage, but are comparatively flat just before the second cleavage. - 1 hr 5 min " [OlatDv:curators] synonym: "2 cell stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage [Term] id: OlatDv:0000070 name: Medaka stage 4 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 hr 45 min Stage 4 (1 hr 45 min) 4 cell stage: The second cleavage furrow develops on the two blastomeres at a right angle to the first cleavage plane. It deepens until each blastomere is divided into 2 of the same size. The oil droplets are larger but fewer and gather toward the vegetal pole. - 1 hr 45 min " [OlatDv:curators] synonym: "4 cell stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000060 ! Medaka stage 3 [Term] id: OlatDv:0000080 name: Medaka stage 5 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 2 hrs 20 min Stage 5 (2 hrs 20 min) 8 cell stage: The third cleavage plane is parallel to the first and divides the 4 blastomeres into 8 blastomeres. The blastoderm has bilaterally symmetrical rows of blastomeres and elongates along the axis of the second cleavage plane. - 2 hrs 20 min " [OlatDv:curators] synonym: "8 cell stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000070 ! Medaka stage 4 [Term] id: OlatDv:0000090 name: Medaka stage 6 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 2 hrs 55 min Stage 6 (2 hrs 55 min) 16 cell stage: The fourth cleavage plane, which is parallel to the second, divides the 2 rows of 4 blastomeres into 4 rows of 4 blastomeres. - 2 hrs 55 min " [OlatDv:curators] synonym: "16 cell stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000080 ! Medaka stage 5 [Term] id: OlatDv:0000100 name: Medaka stage 7 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 3 hrs 30 min Stage 7 (3 hrs 30 min) 32 cell stage: The fifth cleavage plane divides the marginal 12blastomeres meridionally into 24, and the central 4 blastomeres horizontally into 8 thereby forming 2 layers, an outer and an inner layer, in the central region. The number of marginal cells is 14. These observations agree with those of Matui [24], Gamo and Terajima [4] and Iwamatsu [11] but differ from the earlier reports of Kamito [21, cf. 30] in which cleavage was reported to continue to occur meridionally at least through the 32 cell stage. - 3 hrs 30 min " [OlatDv:curators] synonym: "32 cell stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000090 ! Medaka stage 6 [Term] id: OlatDv:0000110 name: Medaka stage 8 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 4 hrs 5 min Stage 8 (4 hrs 5 min) Early morula stage: The planes of the sixth and later cleavages are difficult to precisely trace. The blastomeres (64-128) have different cleavage planes depending on their positions within the dome-shaped blastoderm and are arranged in 3 layers. The peripheral blastomeres (21-24) are flattened in shape. The cells (30-35 m in diameter) are arranged in 3-4 layers but are still easily dissociated from each other [31]. - 4 hrs 5 min " [OlatDv:curators] synonym: "early morula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000100 ! Medaka stage 7 [Term] id: OlatDv:0000120 name: Medaka stage 9 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 5 hrs 15 min Stage 9 (5 hrs 15 min) Late morula stage: The blastodermal cells (256-512 blastomeres) are smaller than those of the previous stage and the number of marginal cells (30- 40) has increased. The blastodermal cells (central region, 25- 35 m in diameter) now form 4-5 layers. - 5 hrs 15 min " [OlatDv:curators] synonym: "late morula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000110 ! Medaka stage 8 [Term] id: OlatDv:0000130 name: Medaka stage 10 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 6 hrs 30 min Stage 10 (6 hrs 30 min) Early blastula stage: The blastoderm (about 1,000 cells) is still high (thick) as in the late morula stage, although its inner cells (20-30 m in diameter) are smaller. According to Kageyama [19], the 11th cleavage still takes place synchronously. Nuclei from the marginal cells (40, cf.[19]) migrate out of the cells and are distributed in a few rows in the periblast (cortical syncytial layer). - 6 hrs 30 min " [OlatDv:curators] synonym: "early blastula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000120 ! Medaka stage 9 [Term] id: OlatDv:0000140 name: Medaka stage 11 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 8 hrs 15 min Stage 11 (8 hrs 15 min) Late blastula stage: Projection of the underside of the blastoderm (central cells, about 20 m in diameter) into the yolk sphere is observed. In this stage, some blastomeres begin to cleave asynchronously and to migrate. Several (5-6) rows of periblast nuclei are visible around the blastoderm. - 8 hrs 15 min " [OlatDv:curators] synonym: "Late blastula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000130 ! Medaka stage 10 [Term] id: OlatDv:0000150 name: Medaka stage 12 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 10 hrs 20 min Stage 12 (10 hrs 20 min) Pre-early gastrula stage: The blastoderm has flattened down onto the yolk sphere so that its outer surface follows the curvature of the yolk sphere. The cell layers are slightly thicker on one side. The diameter of the cells in the central region of the blastoderm remains about 20 m. - 10 hrs 20 min " [OlatDv:curators] synonym: "pre-early gastrula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000140 ! Medaka stage 11 [Term] id: OlatDv:0000160 name: Medaka stage 13 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 13 hrs 0 min Stage 13 (13 hrs 0 min) Early gastrula stage: The blastoderm begins to expand (epiboly, about 1/4 of the yolk sphere) over the surface of the yolk sphere, and the presumptive region of the embryonic shield arises as a thickened margin (dorsal lip) of the blastoderm. It is difficult to recognize the boundaries of the flattened marginal cells. The diameter of the cells in the central region of the blastoderm is 15-20 m. - 13 hrs 0 min " [OlatDv:curators] synonym: "early gastrula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000150 ! Medaka stage 12 [Term] id: OlatDv:0000170 name: Medaka stage 14 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 15 hrs 0 min Stage 14 (15 hrs 0 min) Pre-mid gastrula stage: Epiboly progressively advances and the blastoderm covers about 1/3 of the yolk sphere. The germ ring is well-defined, and the embryonic shield increases in size. Weak, rhythmically undulating movements [3,29] begin to occur on the blastoderm but not on the uncovered yolk sphere. - 15 hrs 0 min " [OlatDv:curators] synonym: "pre-mid gastrula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000160 ! Medaka stage 13 [Term] id: OlatDv:0000180 name: Medaka stage 15 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 17 hrs 30 min Stage 15 (17 hrs 30 min) Mid gastrula stage: A streak is visible in the midline of the embryonic shield projecting into the germ ring area. The blastoderm covers about 1/2 of the yolk sphere. The nuclei of the marginal periblast are barely visible on the yolk sphere. - 17 hrs 30 min " [OlatDv:curators] synonym: "mid gastrula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000170 ! Medaka stage 14 [Term] id: OlatDv:0000190 name: Medaka stage 16 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 21 hrs 0 min Stage 16 (21 hrs 0 min) Late gastrula stage: The blastoderm covers 3/4 of the yolk sphere, and the embryonic shield (body) becomes more clearly visible as a narrow streak. The enveloping layer expands uniformly over the yolk sphere until this stage [18]. - 21 hrs 0 min " [OlatDv:curators] synonym: "Late gastrula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000180 ! Medaka stage 15 [Term] id: OlatDv:0000200 name: Medaka stage 17 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 1 hr Stage 17 (1 day 1 hr) Early neurula stage (Head formation): The yolk sphere is nearly covered by the thin blastoderm leaving a small area around the vegetal pole (yolk plug) ex- posed. The head (rudimentary brain) is recognized anteriorly in the distinct embryonic body. A beak-like mass of cells is seen in front of the head. A few small vacuoles (Kupffer's vesicles) appear at the underside of the caudal (posterior) end of the body, which is in contact with a small blastopore. - 1 day 1 hr " [OlatDv:curators] comment: Head formation synonym: "early neurula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000190 ! Medaka stage 16 [Term] id: OlatDv:0000210 name: Medaka stage 18 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 2 hrs Stage 18 (1 day 2 hrs) Late neurula stage (Optic bud formation): The brain and nerve cord in the arrow-shaped embryonic body codevelop as a solid rod of cells. A solid optic bud (rudimentary eye vesicle) appears on each side of the cephalic end. The beak- like cell mass is still visible. The Kufpper's vesicles enlarge somewhat. A small part of the yolk sphere still forms a blastopore at the vegetal pole. - 1 day 2 hrs " [OlatDv:curators] comment: Optic bud formation synonym: "late neurula stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000200 ! Medaka stage 17 [Term] id: OlatDv:0000220 name: Medaka stage 19 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 3 hrs 30 min Stage 19 (1 day 3 hrs 30 min) 2 somite stage: A groove appears in the dorsum of each optic lobe. At the end of this stage (3 somites), two slight knobs are recognized behind the optic vesicles. The blastopore is completely closed. The expansion of the enveloping layer is accomplished without an accompanying increase in the number of constituent cells [18]. - 1 day 3 hrs 30 min " [OlatDv:curators] synonym: "2 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000210 ! Medaka stage 18 [Term] id: OlatDv:0000230 name: Medaka stage 20 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 7 hrs 30 min Stage 20 (1 day 7 hrs 30 min) 4 somite stage: A paired placode of otic (auditory) vesicles appears at the posterior region of the head. Depressions begin to form at the dorsal surface of the eye vesicles. Three parts of the brain (the fore-, the mid- and the hind-brain) are discernible. - 1 day 7 hrs 30 min " [OlatDv:curators] synonym: "4 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000220 ! Medaka stage 19 [Term] id: OlatDv:0000240 name: Medaka stage 21 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 10 hrs Stage 21 (1 day 10 hrs) 6 somite stage (Brain and otic vesicle formation): The optic vesicles differentiate to form the optic cups and the lenses begin to form. The small otic vesicles appear, but they lack otolith. The three regions of the brain are well- defined, and the neural fold (neurocoele) is seen as a median line along the body. The flat body cavity is recognized on the surface of the yolk sphere bilateral to the mid-brain and hind- brain. - 1 day 10 hrs " [OlatDv:curators] comment: Brain and otic vesicle formation synonym: "6 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000230 ! Medaka stage 20 [Term] id: OlatDv:0000250 name: Medaka stage 22 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 14 hrs Stage 22 (1 day 14 hrs) 9 somite stage (Appearance of heart anlage): The tubular heart (heart anlage) appears underneath the head from the posterior end of the mid-brain to the anterior end of the hind-brain. The anlage of the hatching enzyme gland (cell mass) appears at the centroventral side of the hind-brain [28]. The body cavity extends further toward the posterior end of the eye vesicles. Melanophores appear on the yolk sphere. Incomplete lenses are present in the eyes, and the vesicular otocyst is defined. - 1 day 14 hrs " [OlatDv:curators] comment: Appearance of heart anlage synonym: "9 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000240 ! Medaka stage 21 [Term] id: OlatDv:0000260 name: Medaka stage 23 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 17 hrs Stage 23 (1 day 17 hrs) 12 somite stage (Formation of tubular heart): The anterior portion of the straight-tubed heart reaches beneath the posterior end of the eye vesicle. A pair of semi-circular Cuvierian ducts (blood vessels) and the vitello-caudal vein begin to form on the yolk sphere. Kupffer's vesicles shrink. The neurocoele is formed in the fore-, mid- and hind-brains. The spherical optic lenses are completed. A blood island becomes pronounced in the ventral region between the 6th and 11th somites. The anterior (the 3rd - 5th) somites assume a slightly dog-legged shape. The oil droplets have coalesced into a single large drop. - 1 day 17 hrs " [OlatDv:curators] comment: Formation of tubular heart synonym: "12 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000250 ! Medaka stage 22 [Term] id: OlatDv:0000270 name: Medaka stage 24 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 1 day 20 hrs Stage 24 (1 day 20 hrs) 16 somite stage (Start of heart beating): The anterior portion of the heart, which exhibits a slow (about 33-64/min) pulsation, extends up to the anterior end of the fore-brain. Cuvierian ducts and the vitello-caudal vein are still in- complete. Kupffer's vesicles have almost disappeared. Otoliths are not yet present in the otic vesicles. The embryonic body encircles nearly 1/2 of the yolk sphere. The gut (digestive) tube is observed ventral to the dogleg-shaped somites. - 1 day 20 hrs " [OlatDv:curators] comment: Start of heart beating synonym: "16 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000260 ! Medaka stage 23 [Term] id: OlatDv:0000280 name: Medaka stage 25 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 2 days 2 hrs Stage 25 (2 days 2 hrs) 18-19 somite stage (Onset of blood circulation): When blood circulation begins, the spherical blood cells are first pushed out of the blood island (7th-15th somites) toward the vitello-caudal vein (Fig. 1). The blood is pumped (70-80 heart- beats/min) from the heart out into the anterior cardinal vein and the dorsal aorta roots. The dorsal aorta branching off the perceptible bulbus arteriosus is paired anteriorly with continuations extending to the head as the internal carotid arteries. The carotid artery splits to form the optic plexus, which connects with the left and right ducts of Cuvier. The left and right dorsal aorta roots run caudally until they join to form the dorsal aorta. The dorsal aorta is unpaired through the trunk region and continues into the tail as the vitello-caudal artery (Fig. 1). A countercurrent of the blood stream from the heart into the aorta is still observed. Otoliths appear as two conglomerates of small granules lying against the inner surface of each well-expanded otocyst. The embryonic body encircles nearly 7/12 of the yolk sphere. The dogleg-shaped somites form a herringbone pattern between the 3rd and 10th somites. Kupffer's vesicles have disappeared completely. The bulge of the liver anlage appears at the 1st- 3rd somites just posterior to the future position of the left pectoral fin in the 19 somite stage. - 2 days 2 hrs " [OlatDv:curators] comment: Onset of blood circulation synonym: "18-19 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000270 ! Medaka stage 24 [Term] id: OlatDv:0000290 name: Medaka stage 26 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 2 days 6 hrs Stage 26 (2 days 6 hrs) 22 somite stage (Development of guanophores and vacuolization of the notochord): Blood containing globular blood cells is pumped out beyond the anterior region of the hind-brain. The caudal vein is observed in the region from the 1st to the 14th somites. The tip of the tail is completely free of the yolk sphere. The anlage of the liver, which first appeared at the 19 somite stage, is not yet well- developed. Red-brown colored guanophores, which first appeared at the ventral side of the mid-brain in the 20 somite embryo, are more clearly seen. Vacuolization of the notochord starts at its anterior region. Differentiating choroidea of the eyes begin to darken due to melanization. - 2 days 6 hrs " [OlatDv:curators] comment: Development of guanophores and vacuolization of the notochord synonym: "22 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000280 ! Medaka stage 25 [Term] id: OlatDv:0000300 name: Medaka stage 27 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 2 days 10 hrs Stage 27 (2 days 10 hrs) 24 somite stage (Appearance of pectoral fin bud): The tip of the tail where the notochord attaches is pointed. The embryonic body with the tail free from the yolk sphere encircles 5/8 of the yolk sphere. The rudiments of the pectoral fins protrude from the body trunk behind the base of the Cuvierian ducts. The eminences of liver rudiment are clearly seen on the left side beneath the 1st-3rd somites, and the gut tube can be seen beneath the 1st-13th somites curving to the left-ventral in the region between the 1st and 3rd somites. The arterial end of the heart has shifted to the right. The tail is free of the yolk sphere, and its vein is observed from the 10th to the 16th somites. - 2 days 10 hrs " [OlatDv:curators] comment: Appearance of pectoral fin bud synonym: "24 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000290 ! Medaka stage 26 [Term] id: OlatDv:0000310 name: Medaka stage 28 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 2 days 16 hrs Stage 28 (2 days 16 hrs) 30 somite stage (Onset of retinal pigmentation): The embryonic body with a caudal vein between the 10th and 22th somites encircles about 2/3 of the yolk sphere. Pigmentation advances around the retina, and several melanophores occupy the dorsal wall of the viscera beneath the 1st to the 5th somites. The bulge of the liver becomes definitive in the left side of the 3rd to 4th somites. The anlage of the pancreas appears as a ventral eminence on the right side beneath and slightly anterior to the 3rd somite. Three sinuous portions of the vitelline veins consisting of the left and right ducts of Cuvier and 4 sinuous portions of the vitello-caudal vein meander on the yolk sphere. The blood cells (8.7 m in diameter) flatten slightly. The posterior of the two otoliths in each otocyst is slightly larger than the anterior. - 2 days 16 hrs " [OlatDv:curators] comment: Onset of retinal pigmentation synonym: "30 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000300 ! Medaka stage 27 [Term] id: OlatDv:0000320 name: Medaka stage 29 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 3 days 2 hrs Stage 29 (3 days 2 hrs) 34 somite stage (Internal ear formation): The embryonic body encircles about 3/4 of the yolk sphere. The anlage of the pineal gland is recognized as a disc-shaped, round structure at the dorsal surface of the 3rd ventricle. In the heart, the sinus venosus, atrium, ventricle and bulbus arteriosus are differentiated. There is a large, transparent membranous protrusion inside the outer wall and another inside the inner wall of the otic vesicle (internal ear formation). In the region posterior to the eye (where gills will form), a group of large hatching enzyme cells has differentiated from endodermal cells [7,28]. A ventral eminence is prominent behind the otic vesicles, and an- other eminence (the presumptive swim bladder) is discernible at the ventral side of the 3rd somite. The pectoral fin is apparent, and membranous fins are also seen in the tail, which has 19 somites beyond the gut tube. Guanophores begin to disperse on the dorsal surface of the body trunk. The anterior tip of the notochord is located where the branches of the dorsal aorta join. - 3 days 2 hrs " [OlatDv:curators] comment: Internal ear formation synonym: "34 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000310 ! Medaka stage 28 [Term] id: OlatDv:0000330 name: Medaka stage 30 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 3 days 10 hrs " [OlatDv:curators] comment: Blood vessel development synonym: "35 somite stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000320 ! Medaka stage 29 [Term] id: OlatDv:0000340 name: Medaka stage 31 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 3 days 23 hrs Stage 31 (3 days 23 hrs) Gill blood vessel formation stage: Large cells of the hatching enzyme gland migrate up to the region under the central part of the eye, which now has a cornea. Blood circulation is seen in the gill arches. Pigmentation of the melanophores in the choroidea proceeds as a dark network in the eye. The pronephric kidney appears as a bright structure adjacent to the 1st somite. The transparent, colorless gallbladder first appears at the posterior region of the liver. Four transparent, membranous protrusions (the structures of the internal ear) are recognized in the otic vesicles. The anterior region of the oral cavity is formed. The tail has 21 somites and a membranous fin which is wider on the ventral side. - 3 days 23 hrs " [OlatDv:curators] synonym: "Gill blood vessel formation stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000330 ! Medaka stage 30 [Term] id: OlatDv:0000350 name: Medaka stage 32 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 4 days 5 hrs Stage 32 (4 days 5 hrs) Somite completion stage (Formation of pronephros and air bladder): The swim (air)bladder is recognized as a transparent vacuolar body beneath the 3rd somite, and the distinct kidneys (pronephroi) lie in contact with the bilateral sides of the notochord in the 1st somite. In the otic vesicles, a tubular (semicircular canals) membranous labyrinth can be seen. In the posterior end of the tail, the somites are indistinct. The number of whole somites counted is 30. Two hours later, the blood stream is twisted in the posterior end of the tail. - 4 days 5 hrs " [OlatDv:curators] comment: Formation of pronephros and air bladder synonym: "somite completion stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000340 ! Medaka stage 31 [Term] id: OlatDv:0000360 name: Medaka stage 33 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 4 days 10 hrs Stage 33 (4 days 10 hrs) Stage at which notochord vacuolization is completed: The tail tip has not yet reached within inter ocular distance of the eye. Because the eyeball (choroidea) is very dark, the lenses can be seen only with strong trans illumination. The notochord is completely vacuolized to the end of the tail. The pineal gland is distinct at the dorsal surface of the vascularized forebrain. The tips of the membranous margins of the pectoral fins reach the 4th somite. - 4 days 10 hrs " [OlatDv:curators] synonym: "stage at which notochord vacuolization is completed" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000350 ! Medaka stage 32 [Term] id: OlatDv:0000370 name: Medaka stage 34 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 5 days 1 hr Stage 34 (5 days 1 hr) Pectoral fin blood circulation stage: The tip of the caudal fin has several melanophores and reaches the eye. Blood circulation is apparent in the pectoral fins, which frequently move (flutter). The choroidea of the eye becomes so black that it is almost impervious to light. - 5 days 1 hr " [OlatDv:curators] synonym: "pectoral fin blood circulation stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000360 ! Medaka stage 33 [Term] id: OlatDv:0000380 name: Medaka stage 35 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 5 days 12 hrs Stage 35 (5 days 12 hrs) Stage at which visceral blood vessels form: The tip of the caudal fin reaches beyond the posterior border of the eye. Guanophores are distributed from the head to the vicinity of the tail tip. Blood circulates through the internal tissues of the head and the viscera to Cuvier's ducts. The tubular structure of the spinal cord is revealed. The opening of the oral cavity to the mouth and the presence of several pit organs on the frontal bone can be recognized. - 5 days 12 hrs " [OlatDv:curators] synonym: "stage at which visceral blood vessels form" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000370 ! Medaka stage 34 [Term] id: OlatDv:0000390 name: Medaka stage 36 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 6 days Stage 36 (6 days) Heart development stage: The tip of the tail reaches the otic vesicle. Guanophores and melanophores are distributed on the dorsal wall (peritoneum) of the peritoneal cavity beneath the 1st to the 4th somites. The extent of flexion of the atrio-ventricular region of the heart increases so that in a lateral view, the atrium and the ventricle lie adjacent to each other. - 6 days " [OlatDv:curators] synonym: "heart development stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000380 ! Medaka stage 35 [Term] id: OlatDv:0000400 name: Medaka stage 37 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 7 days Stage 37 (7 days) Pericardial cavity formation stage: The tip of the tail lies just past the otic vesicle (total length ca. 3.1 mm). The pharyngeal teeth are visible in the posterior region of the gills between the otic vesicles. The pericardial cavity (cardiac sac) surrounding the heart is easily observed. The slowly moving gut tube has a narrow lumen. - 7 days " [OlatDv:curators] synonym: "pericardial cavity formation stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000390 ! Medaka stage 36 [Term] id: OlatDv:0000410 name: Medaka stage 38 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 8 days Stage 38 (8 days) Spleen development stage (Differentiation of caudal fin begins): The tip of the tail extends beyond the otic vesicle (total length ca. 3.6 mm), and the rudiments of the caudal fin rays can be seen within the round membranous fin. The spleen is recognized as a small reddish globule dorsal to the gut tube beneath the left region of the 3rd-4th somites. The gut tube curves to the left between the 1st and the 4th somites, appearing to detour around the swim bladder (3rd-4th somites). A large well- developed gallbladder can be identified by its yellow or yellowish green tint. Both eyes move actively at the same time accompanying movement of the mouth and the pectoral fins. - 8 days " [OlatDv:curators] comment: Differentiation of caudal fin begins synonym: "spleen development stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000400 ! Medaka stage 37 [Term] id: OlatDv:0000420 name: Medaka stage 39 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - 9 days Stage 39 (9 days) Hatching stage: The tip of the tail extends to the base of the pectoral fin or to the posterior region of the swim bladder (total length 3.8- 4.2 mm). After hatching, the internal wall of the swim bladder expands remarkably. Cells of hatching gland have already disappeared. The embryos dissolve the inner layers of the chorion [27], tear the single outer layer by moving the body and escape from the chorion tail-first. - 9 days " [OlatDv:curators] synonym: "hatching stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000410 ! Medaka stage 38 [Term] id: OlatDv:0000430 name: Medaka stage 40 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - Stage 40 1st fry stage: This period extends from hatching until fin rays appear in the caudal and pectoral fins (total length about 4.5 mm). - " [OlatDv:curators] synonym: "1st fry stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000420 ! Medaka stage 39 [Term] id: OlatDv:0000440 name: Medaka stage 41 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - Stage 41 2nd fry stage: This period begins after the appearance of jointed rays in the pectoral fins and continues until fin rays appear in the dorsal and anal fins (total length about 5.5 mm). - " [OlatDv:curators] synonym: "2nd fry stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000430 ! Medaka stage 40 [Term] id: OlatDv:0000450 name: Medaka stage 42 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - Stage 42 3rd fry stage: This stage follows the appearance of ventral fin rays and scales in addition and extends to the formation of the jointed fin rays in the dorsal and anal fins (total length about 7 mm). - " [OlatDv:curators] synonym: "3rd fry stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000440 ! Medaka stage 41 [Term] id: OlatDv:0000460 name: Medaka stage 43 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - Stage 43 1st young fish stage: This is the period before the secondary sexual characteristics are manifested (total length about 22 mm). - " [OlatDv:curators] synonym: "1st young fish stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000450 ! Medaka stage 42 [Term] id: OlatDv:0000470 name: Medaka stage 44 namespace: medaka_ontology def: "Zoological Science 11: 825-839 (1994) - Stage 44 2nd young fish stage: At this stage the mature fish ejaculate sperm and spawn eggs (total length about 23 mm ). - " [OlatDv:curators] synonym: "2nd young fish stage" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by OlatDv:0000460 ! Medaka stage 43 [Term] id: UBERON:0000000 name: processual entity namespace: uberon def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." [span:ProcessualEntity] subset: upper_level [Term] id: UBERON:0000066 name: fully formed stage namespace: uberon def: "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both juvenile stage, and adult stage. " [UBERON:cjm] synonym: "adult stage" BROAD [] synonym: "fully formed animal stage" EXACT [] synonym: "juvenile-adult stage" EXACT [] xref: BilaDO:0000004 xref: BTO:0001043 xref: EFO:0001272 xref: FBdv:00005369 xref: WBls:0000041 xref: XtroDO:0000084 is_a: UBERON:0000092 ! post-embryonic stage relationship: preceded_by UBERON:0000111 ! organogenesis stage [Term] id: UBERON:0000067 name: embryo stage part namespace: uberon def: "A stage that is part of the embryo stage." [UBERON:cjm] subset: grouping_class synonym: "embryonic stage part" EXACT [] is_a: UBERON:0000105 ! life cycle stage intersection_of: UBERON:0000105 ! life cycle stage intersection_of: part_of UBERON:0000068 ! embryo stage relationship: part_of UBERON:0000068 ! embryo stage [Term] id: UBERON:0000068 name: embryo stage namespace: uberon def: "A life cycle stage that starts with fertilization and ends with the fully formed embryo." [] synonym: "embryogenesis" RELATED [] synonym: "embryonic stage" EXACT [] xref: BilaDO:0000002 xref: EV:0300001 xref: FBdv:00005289 xref: HsapDv:0000002 xref: MmusDv:0000002 xref: OGES:000000 xref: OGES:000022 xref: SCTID:296280003 xref: XAO:1000012 is_a: UBERON:0000105 ! life cycle stage disjoint_from: UBERON:0000092 ! post-embryonic stage relationship: part_of UBERON:0000104 ! life cycle [Term] id: UBERON:0000069 name: larval stage namespace: uberon def: "a distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle." [Wikipedia:Larva] comment: It is a misunderstanding that the larval form always reflects the group's evolutionary history. It could be the case, but often the larval stage has evolved secondarily, as in insects. In these cases the larval form might differ more from the group's common origin than the adult form[WP]. Uberon includes clade-specific subclasses. synonym: "ammocoete" NARROW SENSU [Wikipedia:Larva] synonym: "ammocoete stage" NARROW SENSU [Wikipedia:Larva] synonym: "bipinnaria" NARROW SENSU [Wikipedia:Larva] synonym: "bipinnaria stage" NARROW SENSU [Wikipedia:Larva] synonym: "caterpillar" NARROW SENSU [Wikipedia:Larva] synonym: "caterpillar stage" NARROW SENSU [Wikipedia:Larva] synonym: "glochidium" NARROW SENSU [Wikipedia:Larva] synonym: "glochidium stage" NARROW SENSU [Wikipedia:Larva] synonym: "grub" NARROW SENSU [Wikipedia:Larva] synonym: "grub stage" NARROW SENSU [Wikipedia:Larva] synonym: "larva" RELATED [] synonym: "larva stage" EXACT [] synonym: "leptocephalus" NARROW SENSU [Wikipedia:Larva] synonym: "leptocephalus stage" NARROW SENSU [Wikipedia:Larva] synonym: "maggot" NARROW SENSU [Wikipedia:Larva] synonym: "maggot stage" NARROW SENSU [Wikipedia:Larva] synonym: "metacestode" NARROW SENSU [BTO:0000859] synonym: "naiad, nymph" NARROW SENSU [Wikipedia:Larva] synonym: "naiad, nymph stage" NARROW SENSU [Wikipedia:Larva] synonym: "nauplius" NARROW SENSU [Wikipedia:Larva] synonym: "nauplius stage" NARROW SENSU [Wikipedia:Larva] synonym: "nymph" NARROW SENSU [Wikipedia:Larva] synonym: "nymph stage" NARROW SENSU [Wikipedia:Larva] synonym: "planula" NARROW SENSU [Wikipedia:Larva] synonym: "planula stage" NARROW SENSU [Wikipedia:Larva] synonym: "tornaria" NARROW SENSU [NCBITaxon:10219] synonym: "trochophore" NARROW SENSU [Wikipedia:Larva] synonym: "trochophore stage" NARROW SENSU [Wikipedia:Larva] synonym: "veliger" NARROW SENSU [Wikipedia:Larva] synonym: "veliger stage" NARROW SENSU [Wikipedia:Larva] synonym: "wriggler" NARROW SENSU [Wikipedia:Larva] synonym: "wriggler stage" NARROW SENSU [Wikipedia:Larva] synonym: "zoea" NARROW SENSU [Wikipedia:Larva] synonym: "zoea stage" NARROW SENSU [Wikipedia:Larva] xref: BTO:0000915 xref: BTO:0000954 xref: EFO:0001303 xref: FBdv:00005336 xref: MIAA:0000400 xref: OGES:000008 xref: ZFS:0000048 is_a: UBERON:0000092 ! post-embryonic stage relationship: immediately_preceded_by UBERON:0000068 ! embryo stage property_value: RO:0002161 NCBITaxon:32524 [Term] id: UBERON:0000070 name: pupal stage namespace: uberon def: "A life stage of some insects undergoing transformation. The pupal stage is found only in holometabolous insects, those that undergo a complete metamorphosis, going through four life stages; embryo, larva, pupa and imago." [Wikipedia:Pupa] synonym: "aurelia stage" NARROW [NCBITaxon:37572, Wikipedia:Pupa] synonym: "chrysalides stage" NARROW [NCBITaxon:37572, Wikipedia:Pupa] synonym: "chrysalis stage" NARROW [NCBITaxon:37572, Wikipedia:Pupa] synonym: "pupa stage" EXACT [] xref: FBdv:00005349 is_a: UBERON:0000092 ! post-embryonic stage relationship: immediately_preceded_by UBERON:0000069 ! larval stage [Term] id: UBERON:0000071 name: death stage namespace: uberon def: "End of the life of an organism." [XAO:0000437] comment: AO notes - ncit:Death is an outcome synonym: "death" RELATED [] xref: XAO:0000437 xref: XtroDO:0000085 is_a: UBERON:0000105 ! life cycle stage relationship: finishes UBERON:0000104 ! life cycle relationship: part_of UBERON:0000104 ! life cycle [Term] id: UBERON:0000092 name: post-embryonic stage namespace: uberon def: "stage succeeding embryo, including mature structure" [UBERON:cjm] comment: In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997) synonym: "post-hatching stage" NARROW [] synonym: "postembryonic" RELATED [] synonym: "postembryonic stage" EXACT [] xref: BilaDO:0000003 xref: MmusDv:0000030 xref: OGES:000010 xref: OGES:000014 xref: OGES:000024 xref: WBls:0000022 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000104 ! life cycle relationship: preceded_by UBERON:0000068 ! embryo stage [Term] id: UBERON:0000104 name: life cycle namespace: uberon def: "An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism." [UBERON:cjm] subset: upper_level synonym: "life" EXACT [] synonym: "lifespan" EXACT [] xref: FBdv_root:00000000 xref: HsapDv:0000000 xref: MmusDv:0000000 xref: ncithesaurus:Life xref: OGES:000011 is_a: UBERON:0000105 ! life cycle stage [Term] id: UBERON:0000105 name: life cycle stage namespace: uberon def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [UBERON:cjm] comment: Editor notes: we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage subset: upper_level synonym: "developmental stage" EXACT [] synonym: "stage" NARROW [] xref: BILS:0000105 xref: EFO:0000399 xref: MmusDv:0000001 xref: ncithesaurus:Developmental_Stage xref: OlatDv:0000010 xref: WBls:0000002 xref: XAO:1000000 xref: ZFS:0000000 xref: ZFS:0100000 is_a: UBERON:0000000 ! processual entity [Term] id: UBERON:0000106 name: zygote stage namespace: uberon def: "A stage at which the organism is a single cell produced by means of sexual reproduction." [Wikipedia:Zygote] synonym: "1-cell stage" EXACT [] synonym: "fertilized egg stage" EXACT [BTO:0000854] synonym: "one cell stage" EXACT [] synonym: "one-cell stage" RELATED [VHOG:0000745] synonym: "zygote" RELATED [VHOG:0000745] synonym: "zygotum" RELATED LATIN [Wikipedia:Zygote] xref: BilaDO:0000005 xref: BILS:0000106 xref: EFO:0001322 xref: EHDAA:27 xref: EMAPA:16033 xref: FBdv:00005288 xref: VHOG:0000745 xref: XAO:1000001 xref: ZFS:0000001 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: starts UBERON:0000104 ! life cycle property_value: UBPROP:0000003 "As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]" xsd:string [Term] id: UBERON:0000107 name: cleavage stage namespace: uberon def: "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." [GO:0040016, Wikipedia:Cleavage_(embryo)] xref: BilaDO:0000006 xref: BILS:0000107 xref: EFO:0001290 xref: MESH:A16.254.270 xref: MmusDv:0000004 xref: OGES:000015 xref: OGES:000020 xref: XAO:1000004 xref: ZFS:0000046 is_a: UBERON:0000067 ! embryo stage part relationship: immediately_preceded_by UBERON:0000106 ! zygote stage relationship: part_of UBERON:0000068 ! embryo stage [Term] id: UBERON:0000108 name: blastula stage namespace: uberon def: "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] xref: BilaDO:0000007 xref: BILS:0000108 xref: EFO:0001282 xref: HsapDv:0000006 xref: http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png xref: http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Blastulation.png/200px-Blastulation.png xref: MmusDv:0000007 xref: OGES:000003 xref: OGES:000016 xref: OGES:000021 xref: OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg xref: XAO:1000003 xref: ZFS:0000045 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000107 ! cleavage stage [Term] id: UBERON:0000109 name: gastrula stage namespace: uberon def: "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GO:0007369] synonym: "blastocystis trilaminaris stage" RELATED [UBERON:cjm] synonym: "trilaminar blastocyst stage" RELATED [UBERON:cjm] synonym: "trilaminar blastoderm stage" RELATED [UBERON:cjm] synonym: "trilaminar disk stage" RELATED [UBERON:cjm] synonym: "trilaminar germ stage" RELATED [UBERON:cjm] synonym: "trilaminar stage" RELATED [UBERON:cjm] xref: BilaDO:0000008 xref: BILS:0000109 xref: EFO:0001296 xref: FBdv:00005317 xref: HsapDv:0000010 xref: MmusDv:0000013 xref: OGES:000004 xref: OGES:000019 xref: XAO:1000005 xref: ZFS:0000047 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000108 ! blastula stage [Term] id: UBERON:0000110 name: neurula stage namespace: uberon def: "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GO:0001841] xref: BilaDO:0000009 xref: BILS:0000110 xref: HsapDv:0000012 xref: MmusDv:0000016 xref: XAO:1000006 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000109 ! gastrula stage [Term] id: UBERON:0000111 name: organogenesis stage namespace: uberon def: "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." [Wikipedia:Organogenesis] synonym: "segmentation stage" RELATED [] xref: BilaDO:0000010 xref: BILS:0000111 xref: HsapDv:0000015 xref: MmusDv:0000018 xref: OGES:000005 xref: OGES:000032 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000110 ! neurula stage [Term] id: UBERON:0000112 name: juvenile stage namespace: uberon comment: Consider renaming this to '(sexually) immature stage'; in mammals this would include infant (nourishment from lactation) and juvenile (prepubertal no longer dependent on mother) synonym: "immature stage" EXACT [VHOG:FB] xref: BILS:0000112 xref: BTO:0002168 xref: EFO:0001300 xref: EV:0300051 xref: OGES:000009 xref: TS28 xref: XAO:1000010 xref: XtroDO:0000083 xref: ZFS:0000051 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000066 ! fully formed stage property_value: UBPROP:0000001 "The stage of being a sexually immature adult animal[XAO:1000010]." xsd:string [Term] id: UBERON:0000113 name: post-juvenile adult stage namespace: uberon def: "The stage of being a sexually mature adult animal." [UBERON:cjm] synonym: "adult stage" BROAD [] xref: BILS:0000113 xref: EFO:0001272 xref: EV:0300064 xref: EV:0300070 xref: MIAA:0000403 xref: MmusDv:0000039 xref: MmusDv:0000040 xref: OGES:000026 xref: OGES:000027 xref: XAO:1000009 xref: ZFS:0000044 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000066 ! fully formed stage relationship: preceded_by UBERON:0000112 ! juvenile stage [Term] id: UBERON:0004707 name: pharyngula stage namespace: uberon def: "A stage that follows the blastula, gastrula and neurula stages. At the pharyngula stage, all vertebrate embryos show remarkable similarities." [Wikipedia:Pharyngula] comment: Corresponds to E7-E11 in Mouse (Galis et al, TREE, 2001) synonym: "pharyngula" RELATED [] synonym: "phylotypic stage" EXACT [] xref: DrerDO:0000052 xref: EFO:0001310 xref: OGES:000006 xref: ZFS:0000050 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000110 ! neurula stage [Term] id: UBERON:0004728 name: amphibian larval stage namespace: uberon def: "Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GO:0002117] comment: AO notes: the XAO class denotes a stage synonym: "larva" RELATED [XAO:1000008] synonym: "larva stage" BROAD [] synonym: "polliwog" NARROW SENSU [Wikipedia:Larva] synonym: "polliwog stage" NARROW SENSU [Wikipedia:Larva] synonym: "tadpole" NARROW SENSU [Wikipedia:Larva] synonym: "tadpole stage" NARROW SENSU [Wikipedia:Larva] xref: XAO:1000008 xref: XtroDO:0000056 is_a: UBERON:0000069 ! larval stage [Term] id: UBERON:0004729 name: nematode larval stage namespace: uberon def: "Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GO:0002119] xref: WBls:0000023 is_a: UBERON:0000069 ! larval stage [Term] id: UBERON:0004730 name: instar larval stage namespace: uberon def: "This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GO:0002168] xref: FBdv:00005336 is_a: UBERON:0000069 ! larval stage [Term] id: UBERON:0007220 name: late embryonic stage namespace: uberon synonym: "embryo late (growth) stage" EXACT [MIAA:0000399] synonym: "embryo late growth stage" RELATED [BTO:0000449] synonym: "embryo late stage" RELATED [BTO:0000449] synonym: "fetal stage" NARROW SENSU [UBERON:cjm] synonym: "fetus" NARROW [MIAA:0000399] synonym: "fetus stage" NARROW SENSU [UBERON:cjm] xref: EV:0300011 xref: EVM:2990031 xref: FBdv:00005333 xref: MIAA:0000399 xref: MmusDv:0000031 xref: OGES:000023 xref: SCTID:367619004 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage [Term] id: UBERON:0007221 name: neonate stage namespace: uberon def: "Of or pertaining to the period of time immediately following birth, or to the newborn." [http://en.wiktionary.org/wiki/neonatal, Wikipedia:Infant] comment: Editor note: consider splitting infant/newborn synonym: "fledgling stage" NARROW SENSU [UBERON:cjm] synonym: "hatchling" NARROW SENSU [UBERON:cjm] synonym: "hatchling stage" NARROW SENSU [UBERON:cjm] synonym: "infant stage" NARROW SENSU [UBERON:cjm] synonym: "neonatal stage" EXACT [OBOL:automatic] synonym: "nestling stage" NARROW SENSU [UBERON:cjm] synonym: "newborn stage" RELATED [UBERON:cjm] xref: BTO:0001762 xref: EV:0300037 xref: HsapDv:0000082 xref: HsapDv:0000083 xref: http://neurolex.org/wiki/Category\:Infant_organism xref: http://neurolex.org/wiki/Category\:Newborn_organism xref: MmusDv:0000038 xref: NIF_Organism:birnlex_695 xref: OGES:000025 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000112 ! juvenile stage [Term] id: UBERON:0007222 name: late adult stage namespace: uberon synonym: "elderly" RELATED [EV:0300123] synonym: "elderly stage" RELATED [EV:0300123] synonym: "geriatric" RELATED [EV:0300123] synonym: "geriatric stage" RELATED [EV:0300123] xref: EV:0300123 xref: HsapDv:0000093 xref: ncithesaurus:Elderly xref: NIF_Organism:birnlex_691 xref: UMLS:C0001792 is_a: UBERON:0000113 ! post-juvenile adult stage [Term] id: UBERON:0007232 name: 2 cell stage namespace: uberon synonym: "NF stage 2 (2-cell)" NARROW SENSU [XAO:1000011] synonym: "two-cell stage" EXACT [OBOL:automatic] xref: EMAPA:16036 xref: XAO:1000011 xref: XtroDO:0000006 xref: ZFS:0000002 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by UBERON:0000106 ! zygote stage relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: UBERON:0007233 name: 4 cell stage namespace: uberon synonym: "four-cell stage" EXACT [OBOL:automatic] synonym: "NF stage 3 (4-cell)" NARROW SENSU [XAO:1000013] xref: XAO:1000013 xref: XtroDO:0000007 xref: ZFS:0000003 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by UBERON:0007232 ! 2 cell stage relationship: part_of UBERON:0000107 ! cleavage stage relationship: starts UBERON:0007234 ! 4-8 cell stage [Term] id: UBERON:0007234 name: 4-8 cell stage namespace: uberon synonym: "four-eight cell stage" EXACT [OBOL:automatic] xref: EMAPA:16037 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by UBERON:0007232 ! 2 cell stage relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: UBERON:0007236 name: 8 cell stage namespace: uberon synonym: "eight-cell stage" EXACT [OBOL:automatic] synonym: "NF stage 4 (8-cell)" NARROW SENSU [XAO:1000014] xref: XAO:1000014 xref: XtroDO:0000008 xref: ZFS:0000004 is_a: UBERON:0000067 ! embryo stage part is_a: UBERON:0000105 ! life cycle stage relationship: finishes UBERON:0007234 ! 4-8 cell stage relationship: immediately_preceded_by UBERON:0007233 ! 4 cell stage relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: UBERON:0008264 name: echinopluteus larval stage namespace: uberon def: "Larval stage in echinoderms characterized by a planktonic and feeding larval form that possesses limb-like outgrowths bearing ciliated bands." [http://www.encyclopedia.com/doc/1O8-echinopluteuslarva.html] synonym: "pluteus larval stage" EXACT [] is_a: UBERON:0000069 ! larval stage [Term] id: UBERON:0009741 name: tailbud stage namespace: uberon def: "Any of the developmental stages from Nieuwkoop and Faber stage 20 to stage 44 (feeding), including the beginning of hatching (NF stage 35/36)." [ISBN:0815318960] xref: XAO:1000007 is_a: UBERON:0000068 ! embryo stage [Term] id: UBERON:0009849 name: tadpole stage namespace: uberon def: "wholly aquatic larval stage in the life cycle of an amphibian, particularly of a frog or toad[WP]. XAO: The stages from feeding to the end of metamorphosis. Encompasses Weisz's first-form tadpole (equivalent to NF stages 45 to 49), second-form tadpole (NF 49 to 56) and third-form tadpole (NF 56 to 60-plus) stages." [ISBN:0471209627, ISSN:0003-276X, Wikipedia:Tadpole] xref: XAO:1000008 is_a: UBERON:0000069 ! larval stage [Term] id: UBERON:0012101 name: perinatal stage namespace: uberon def: "the period spanning the range immediately before and after birth" [] comment: In birds, the paranatal stage starts when the beak penetrates into the air pocket (air cell) between the inner and outer shell membranes synonym: "paranatal stage" NARROW [] is_a: UBERON:0000105 ! life cycle stage relationship: overlaps UBERON:0000068 ! embryo stage relationship: overlaps UBERON:0000092 ! post-embryonic stage [Term] id: XAO:1000002 name: early tailbud (Xenopus) namespace: xenopus_developmental_stage def: "The stages from Nieuwkoop and Faber stage 22 to stage 28." [ISBN:0815318960] is_a: UBERON:0009741 ! tailbud stage [Term] id: XAO:1000015 name: NF stage 5 (16-cell) (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 5; age 2 hr 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Advanced sixteen cell stage. Dorsal micromeres distinctly smaller and less pigmented than ventral ones. Macromeres entirely separated by cleavage grooves. Length: 1.4 - 1.5 mm." [ISBN:0815318960] synonym: "16-cell stage" EXACT [] xref: ZFS:0000005 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000107 ! cleavage stage relationship: preceded_by UBERON:0007236 ! 8 cell stage [Term] id: XAO:1000016 name: NF stage 6 (32-cell) (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 6; age 3 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Advanced thirty-two cell stage. Distinction between dorsal and ventral micromeres as in preceding stage. Length: 1.4 - 1.5 mm." [ISBN:0815318960] synonym: "32-cell stage" EXACT [] xref: ZFS:0000006 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000107 ! cleavage stage relationship: preceded_by XAO:1000015 ! NF stage 5 (16-cell) (Xenopus) [Term] id: XAO:1000017 name: NF stage 7 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 7, 64-cell embryo; age 4 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Large-cell blastula stage. In animal view about 10 micromeres along meridian. Length: 1.4 - 1.5 mm." [ISBN:0815318960] synonym: "64-cell stage" EXACT [] xref: ZFS:0000007 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000108 ! blastula stage [Term] id: XAO:1000018 name: NF stage 8 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 8, 128-cell embryo; age 5 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Medium-cell blastula stage. Surface not yet entirely smooth. Border of animal pigment cap more diffuse at dorsal than at lateral and ventral sides. Gradual transition in cell size from animal to vegetative pole. Length: 1.4 - 1.5 mm." [ISBN:0815318960] synonym: "128-cell stage" EXACT [] xref: ZFS:0000008 is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000108 ! blastula stage relationship: preceded_by XAO:1000017 ! NF stage 7 (Xenopus) [Term] id: XAO:1000019 name: NF stage 9 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 9; age 7 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Fine-cell blastula stage. Animal cells smaller at dorsal than at ventral side. Border between marginal zone and vegetative field distinct, particularly dorsally, owing to difference in cell size. Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000108 ! blastula stage relationship: preceded_by XAO:1000018 ! NF stage 8 (Xenopus) [Term] id: XAO:1000020 name: NF stage 10 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 10; age 9 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Initial gastrula stage. First indication of blastopore only by pigment concentration. No formation of groove. Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000109 ! gastrula stage relationship: preceded_by XAO:1000019 ! NF stage 9 (Xenopus) [Term] id: XAO:1000021 name: NF stage 11 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 11; age 11 hr 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Horse-shoe-shaped blastopore stage. Blastopore groove surrounding about half of future yolk plug and indicated at its ventral side; future yolk plug often rounded rectangular, slightly elongated in dorso-ventral direction, diameter more than two-fifths of diameter of egg (plus or minus 50 degrees of circumference). Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000109 ! gastrula stage relationship: preceded_by XAO:1000031 ! NF stage 10.5 (Xenopus) [Term] id: XAO:1000022 name: NF stage 12 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 12; age 13 hr 15 min at 22-24 Celsius; corresponding to the following external morphological criteria: Medium yolk plug stage. Yolk plug circular; diameter somewhat less than one fourth of diameter of egg (plus or minus 25 degrees). More and less pigmented fields radiating from yolk plug. Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000109 ! gastrula stage relationship: preceded_by XAO:1000032 ! NF stage 11.5 (Xenopus) [Term] id: XAO:1000023 name: NF stage 13 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 13; age 14 hr 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Slit-blastopore stage. Neural plate faintly delimited; slight elevation of its rostral part and slight flattening of its caudal part. Caudal part of median groove formed. Length: 1.5 - 1.6 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000033 ! NF stage 12.5 (Xenopus) [Term] id: XAO:1000024 name: NF stage 14 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 14; age 16 hr 15 min at 22-24 Celsius; corresponding to the following external morphological criteria: Neural plate stage. Cerebral part of neural plate bent downwards, with median elevation at rostral end of median groove. Initial elevation of neural folds, most pronounced in future nucal region. Blastopore always slit-shaped. Length: 1.5 - 1.6 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000023 ! NF stage 13 (Xenopus) [Term] id: XAO:1000025 name: NF stage 15 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 15; age 17 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Early neural fold stage. Presumptive cement gland faintly circumscribed. Anterior part of neural plate roundish. Neural folds distinct, except medio-rostrally; initial formation of sharp inner ridges on neural folds in rhombencephalic region. Length: 1.5 - 1.6 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000024 ! NF stage 14 (Xenopus) [Term] id: XAO:1000026 name: NF stage 16 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 16; age 18 hr 15 min at 22-24 Celsius; corresponding to the following external morphological criteria: Mid neural fold stage. Anterior part of neural plate rectangular; darkly pigmented eye anlagen present; neural plate sharply constricted in the middle. Inner ridges on neural folds forming angle of about 90 degrees with neural plate in rhombencephalic region. Length: 1.5 - 1.6 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000025 ! NF stage 15 (Xenopus) [Term] id: XAO:1000027 name: NF stage 17 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 17; age 18 hr 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Late neural fold stage. Anterior part of neural plate oblong triangular, angles formed by eye anlagen. Neural folds approaching each other from blastopore up to anterior trunk region. Length: 1.5 - 1.6 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000026 ! NF stage 16 (Xenopus) [Term] id: XAO:1000028 name: NF stage 2- (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 2-; age 1 hr 15 min at 22-24 Celsius; corresponding to the following external morphological criteria: Beginning of first cleavage. First cleavage groove has not yet reached vegetal pole. Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000107 ! cleavage stage relationship: preceded_by UBERON:0000106 ! zygote stage [Term] id: XAO:1000030 name: NF stage 10.25 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 10.25; age 10 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Early gastrula stage. First formation of dorsal blastopore groove; the groove is still straight. Length: 1.4 - 1.5 mm." [ISBN:0815318960] synonym: "NF stage 10+" EXACT [] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000109 ! gastrula stage relationship: preceded_by XAO:1000020 ! NF stage 10 (Xenopus) [Term] id: XAO:1000031 name: NF stage 10.5 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 10.5; age 11 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Crescent-shaped blastopore stage. Blastopore groove angular. Vegetal field slightly decreased in size, ventral border of future yolk plug indicated by pigment contraction. Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000109 ! gastrula stage relationship: preceded_by XAO:1000030 ! NF stage 10.25 (Xenopus) [Term] id: XAO:1000032 name: NF stage 11.5 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 11.5; age 12 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Large yolk plug stage. Blastopore groove closed ventrally; yolk plug not yet quite circular. At ventral side concentrated superficial pigment still visible. Diameter of yolk plug about a third of diameter of egg (plus or minus 40 degrees). Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000109 ! gastrula stage relationship: preceded_by XAO:1000021 ! NF stage 11 (Xenopus) [Term] id: XAO:1000033 name: NF stage 12.5 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 12.5; age 14 hr 15 min at 22-24 Celsius; corresponding to the following external morphological criteria: Small yolk plug stage. Future position of neural plate and median groove indicated by darker pigment lines. Yolk plug usually ovoid, variable in size. Length: 1.4 - 1.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000109 ! gastrula stage relationship: preceded_by XAO:1000022 ! NF stage 12 (Xenopus) [Term] id: XAO:1000034 name: NF stage 18 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 18; age 19 hr 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Neural groove stage. Anterior part of neural plate narrow, more or less club-shaped, often narrower towards rostral end. Parallel neural folds in trunk region very close to each other, not yet touching. Length: 1.5 - 1.6 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000027 ! NF stage 17 (Xenopus) [Term] id: XAO:1000035 name: NF stage 19 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 19; age 20 hr 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Initial neural tube stage. Neural folds touching each other, except for inconstant openings at anterior and posterior end and behind nucal region. Considerable lateral extension of brain. Lateral outline of embryo still convex. Length: 1.5 - 1.6 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000034 ! NF stage 18 (Xenopus) [Term] id: XAO:1000036 name: NF stage 20 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 20; age 21 hr 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Neural folds fused, suture still present. The two eye anlagen showing through dumb-bell-shaped, eyes hardly protruding. Beginning of stretching of embryos. Lateral outline flat. Length: 1.7 - 1.8 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000035 ! NF stage 19 (Xenopus) [Term] id: XAO:1000037 name: NF stage 21 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 21; age 22 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Suture of neural tube completely closed. Delimitation of frontal field by pigment lines. Primary eye vesicles showing through in the form of two separate, obliquely placed oval spots; beginning of protrusion of eyes. Lateral outline of embryo just becoming concave, ventral outline flat. Length: 1.9 - 2.0 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000110 ! neurula stage relationship: preceded_by XAO:1000036 ! NF stage 20 (Xenopus) [Term] id: XAO:1000038 name: NF stage 22 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 22; age 24 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Distinct protrusion of eyes. Initial groove between jaw- and gill-areas only at latero-dorsal side. Lateral and ventral outlines of embryo slightly concave. Anal opening displaced to ventral side. Vitelline membrane becoming wider. Length: 2.0 - 2.2 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000002 ! early tailbud (Xenopus) relationship: preceded_by XAO:1000037 ! NF stage 21 (Xenopus) [Term] id: XAO:1000039 name: NF stage 23 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 23; age 1 day, 45 min at 22-24 Celsius; corresponding to the following external morphological criteria: Jaw- and gill-areas completely separated by groove. Ventral outline of embryo more concave. Length: 2.2 - 2.4 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000002 ! early tailbud (Xenopus) relationship: preceded_by XAO:1000038 ! NF stage 22 (Xenopus) [Term] id: XAO:1000040 name: NF stage 24 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 24; age 1 day, 2 hr 15 min at 22-24 Celsius; corresponding to the following external morphological criteria: Eyes protruding less far laterally than gill-area. Gill-area more prominent than jaw-area, gill-area not yet grooved. Ventral outline of embryo nicked. Tail bud discernible. Initial motor reactions to external stimulation. Length: 2.5 - 2.7 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000002 ! early tailbud (Xenopus) relationship: preceded_by XAO:1000039 ! NF stage 23 (Xenopus) [Term] id: XAO:1000041 name: NF stage 25 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 25; age 1 day, 3 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Eyes protruding equally far or further laterally than gill-area. Gill-area grooved. Invagination of otic vesicle indicated by pigment spot. Beginning of fin formation. Length: 2.8 - 3.0 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000002 ! early tailbud (Xenopus) relationship: preceded_by XAO:1000040 ! NF stage 24 (Xenopus) [Term] id: XAO:1000042 name: NF stage 26 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 26; age 1 day, 5 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: otic vesicle protruding. Pronephros distinctly visible. Myotomes showing through for the first time. Fin somewhat broadened at dorso-caudal end of body. Beginning of spontaneous movements. Length: 3.0 - 3.3 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000002 ! early tailbud (Xenopus) relationship: preceded_by XAO:1000041 ! NF stage 25 (Xenopus) [Term] id: XAO:1000043 name: NF stage 27 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 27; age 1 day, 7 hr 15 min at 22-24 Celsius; corresponding to the following external morphological criteria: Lateral flattening of eyes. Fin transluscent, except for region behind anus. Tail bud formation accentuated in lateral outline. Length: 3.4 - 3.7 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000002 ! early tailbud (Xenopus) relationship: preceded_by XAO:1000042 ! NF stage 26 (Xenopus) [Term] id: XAO:1000044 name: NF stage 28 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 28; age 1 day, 8 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Fin extending up to anus. Fin broadened and distinctly divided into outer transparent and inner translucent band. Length: 3.8 - 4.0 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000002 ! early tailbud (Xenopus) relationship: preceded_by XAO:1000043 ! NF stage 27 (Xenopus) [Term] id: XAO:1000045 name: NF stage 29 and 30 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 29 and 30; age 1 day, 11 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Gray eye cup showing through for the first time. Fin transparent up to the base over its whole length. Tail bud distinct. Length: 4.0 - 4.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000044 ! NF stage 28 (Xenopus) [Term] id: XAO:1000046 name: NF stage 31 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 31; age 1 day, 13 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Tail bud equally long as broad. Length: 4.2 - 4.8 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000045 ! NF stage 29 and 30 (Xenopus) [Term] id: XAO:1000047 name: NF stage 32 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 32; age 1 day, 16 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Eye cup horse-shoe-shaped, standing out distinctly. Length of tail bud about 1.5 times its breadth. Length: 4.5 - 5.1 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000046 ! NF stage 31 (Xenopus) [Term] id: XAO:1000048 name: NF stage 33 and 34 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 33 and 34; age 1 day, 20 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Stomodeal invagination a shallow vertical groove. Dorsal part of eye more pigmented than ventral part; distinct melanophores in dorsal part. Melanophores appearing dorsally on the head and laterally in a row extending from just below the pronephros backwards. Length of tail bud about twice its breadth. Beginning of heart beat. Length: 4.7 - 5.3 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000047 ! NF stage 32 (Xenopus) [Term] id: XAO:1000049 name: NF stage 35 and 36 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 35 and 36; age 2 days, 2 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Stomodeal invagination roundish. Eye entirely black, choroid fissure nearly closed. Formation of two gill rudiments, anterior one nipple-shaped. Melanophores appearing on back. Posterior outline of proctodeum still curved. Length of tail bud about three times its breadth. Beginning of hatching. Length: 5.3 - 6.0 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000048 ! NF stage 33 and 34 (Xenopus) [Term] id: XAO:1000050 name: NF stage 37 and 38 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 37 and 38; age 2 days, 5 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Stomodeal invagination much deeper, opening round. Both gill rudiments nipple-shaped, a branch of the anterior one indicated. Posterior outline of proctodeum straight, forming very obtuse angle with ventral border of tail myotomes. Melanophores spreading over tail. Length: 5.6 - 6.2 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000049 ! NF stage 35 and 36 (Xenopus) [Term] id: XAO:1000051 name: NF stage 39 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 39; age 2 days, 8 hr 30 min at 22-24 Celsius; corresponding to the following external morphological criteria: Melanophores appearing around nasal pits. Opening of stomodeal invagination transversely elongated. Melanophores on back arranged in a superficial and a deeper layer. Outlines of proctodeum and tail myotomes forming angle of about 135 degrees. Melanophores appearing along ventral edge of tail musculature. Length: 5.9 - 6.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000050 ! NF stage 37 and 38 (Xenopus) [Term] id: XAO:1000052 name: NF stage 40 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 40; age 2 days, 18 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Mouth broken through. Length of gills about twice their breadth, posterior one sometimes also showing a branch. Outlines of proctodeum and tail myotomes forming angles of 90 degrees. Beginning of blood circulation in gills. Length: 6.3 - 6.8 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000051 ! NF stage 39 (Xenopus) [Term] id: XAO:1000053 name: NF stage 41 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 41; age 3 days, 4 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Gills broader and flatter, more laterally directed. Formation of a left-rostral and a right-caudal furrow in yolk mass; torsion of interjacent part about 45 degrees; formation of conical proctodeum, forming angle of about 60 degrees with tail myotomes. Formation of fin rostral to proctodeum; ventral outline of yolk mass and proctodeum a smooth concave line. Length: 6.7 - 7.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000052 ! NF stage 40 (Xenopus) [Term] id: XAO:1000054 name: NF stage 42 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 42; age 3 days, 8 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Beginning of formation of opercular folds. Torsion of intestine about 90 degrees; proctodeum connected with yolk mass by short horizontal intestinal tube. Length: 7.0 - 7.7 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000053 ! NF stage 41 (Xenopus) [Term] id: XAO:1000055 name: NF stage 43 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 43; age 3 days, 15 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Lateral line system becoming visible externally. Cement gland losing its pigment. Torsion of intestine about 180 degrees; proctodeum narrower, arched or S-shaped. Length: 7.5 - 8.3 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000054 ! NF stage 42 (Xenopus) [Term] id: XAO:1000056 name: NF stage 44 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 44; age 3 days, 20 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Appearance of tentacle rudiments. Opercular folds protruding further. Coiling part of intestine showing S-shaped loop; torsion about 360 degrees. Blood-circulation in gills usually ceased (gills smaller). Length: 7.8 - 8.5 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000080 ! late tailbud (Xenopus) relationship: preceded_by XAO:1000055 ! NF stage 43 (Xenopus) [Term] id: XAO:1000057 name: NF stage 45 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 45; age 4 days, 2 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Operculum partly covering gills, edge still straight. Intestine spiralized in ventral aspects, showing 1.5 revolutions. Beginning of feeding. Length: 8 - 10 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000056 ! NF stage 44 (Xenopus) [Term] id: XAO:1000058 name: NF stage 46 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 46; age 4 days, 10 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Edge of operculum becoming convex. Xantophores appearing on eye and abdomen. Intestine showing 2 to 2.5 revolutions. Hindlimb bud visible for the first time. Length: 9 - 12 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000057 ! NF stage 45 (Xenopus) [Term] id: XAO:1000059 name: NF stage 47 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 47; age 5 days, 12 hr at 22-24 Celsius; corresponding to the following external morphological criteria: Tentacles larger. Edge of operculum forming quarter of a circle. Xantophores forming opaque layer on abdomen. Intestine showing 2.5 to 3.5 revolutions. Hindlimb bud more distinct. Length: 12 - 15 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000058 ! NF stage 46 (Xenopus) [Term] id: XAO:1000060 name: NF stage 48 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 48; age 7.5 days at 22-24 Celsius; corresponding to the following external morphological criteria: Beginning of pigmentation around n. acusticus. Forelimb bud visible for the first time. Shining gold-coloured abdomen. Hindlimb bud semicircular in lateral aspect. Length: 14 - 17 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000059 ! NF stage 47 (Xenopus) [Term] id: XAO:1000061 name: NF stage 49 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 49; age about 12 days at 22-24 Celsius; corresponding to the following external morphological criteria: Melanophores usually appearing around thymus gland and nerves and blood vessels of head; xantophores appearing on pericard. Forelimb bud distinct. Hindlimb bud somewhat longer, distal outline still circular, no constrictions at base. Melanophores appearing on dorsal and ventral fin. Length: 17 - 23 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000060 ! NF stage 48 (Xenopus) [Term] id: XAO:1000062 name: NF stage 50 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 50; age about 15 days at 22-24 Celsius; corresponding to the following external morphological criteria: Forelimb bud somewhat oval-shaped in dorsal aspect. Hindlimb bud longer than broad, constricted at base, distal outline somewhat conical. Length: 20 - 27 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000061 ! NF stage 49 (Xenopus) [Term] id: XAO:1000063 name: NF stage 51 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 51; age about 17 days at 22-24 Celsius; corresponding to the following external morphological criteria: Tentacles much longer. Forelimb bud oval-shaped in lateral aspect. Hindlimb bud conical in shape, its length about 1.5 times its breadth; melanophores appearing on it. Length: 28 - 36 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000062 ! NF stage 50 (Xenopus) [Term] id: XAO:1000064 name: NF stage 52 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 52; age about 21 days at 22-24 Celsius; corresponding to the following external morphological criteria: Forelimb bud irregularly conical. Hindlimb bud showing first indication of ankle constriction and first sign of flattening of foot. Length: 42 - 56 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000063 ! NF stage 51 (Xenopus) [Term] id: XAO:1000065 name: NF stage 53 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 53; age about 24 days at 22-24 Celsius; corresponding to the following external morphological criteria: Fore- and hindlimbs in paddle stage. Hindlimb whithout foot somewhat longer than broad; 4th and 5th toe indicated. Length: 50 - 60 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000064 ! NF stage 52 (Xenopus) [Term] id: XAO:1000066 name: NF stage 54 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 54; age about 26 days at 22-24 Celsius; corresponding to the following external morphological criteria: All four fingers indicated; edge of hand slightly scalloped between fingers; melanophores appearing on forelimb. Length of hindlimb without foot nearly twice its breadth; all five toes indicated, the second only very slightly. Length: 58 - 65 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000089 ! premetamorphosis (Xenopus) relationship: preceded_by XAO:1000065 ! NF stage 53 (Xenopus) [Term] id: XAO:1000067 name: NF stage 55 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 55; age about 32 days at 22-24 Celsius; corresponding to the following external morphological criteria: Hand pronated about 90 degrees; free parts of fingers about equally long as broad. Length of hindlimb without foot about 3 times its breadth; length of cartilages of 4th and 5th toe about 4 times their breadth. Length: 70 - 80 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000090 ! prometamorphosis (Xenopus) relationship: preceded_by XAO:1000066 ! NF stage 54 (Xenopus) [Term] id: XAO:1000068 name: NF stage 56 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 56; age about 38 days at 22-24 Celsius; corresponding to the following external morphological criteria: Elbow and wrist clearly indicated; length of free parts of fingers 3 to 4 times their breadth. Length of cartilages of 4th and 5th toe about 6 times their breadth. Length: 70 - 100 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000090 ! prometamorphosis (Xenopus) relationship: preceded_by XAO:1000067 ! NF stage 55 (Xenopus) [Term] id: XAO:1000069 name: NF stage 57 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 57; age about 41 days at 22-24 Celsius; corresponding to the following external morphological criteria: Pigment-free spot appearing above \"Stirnorgan\". Angle of elbow more than 90 degrees; fingers stretched out in forelimb atrium, their length about 7 times their breadth. Length: 75 - 105 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000090 ! prometamorphosis (Xenopus) relationship: preceded_by XAO:1000068 ! NF stage 56 (Xenopus) [Term] id: XAO:1000070 name: NF stage 58 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 58; age about 44 days at 22-24 Celsius; corresponding to the following external morphological criteria: Forelimbs broken through. Guanophores appearing on abdomen and thighs (adult skin areas). All three claws present on hindlimbs. Length: 80 - 110 mm." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000069 ! NF stage 57 (Xenopus) [Term] id: XAO:1000071 name: NF stage 59 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 59; age about 45 days at 22-24 Celsius; corresponding to the following external morphological criteria: Tentacles beginning to shrivel up. Stretched forelimb reaching down to base of hindlimb. Guanophores appearing near base of forelimb (adult skin area); anterior border of adult skin area on abdomen not yet sharp; appearance of irregular dark spots on back." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000070 ! NF stage 58 (Xenopus) [Term] id: XAO:1000072 name: NF stage 60 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 60; age about 46 days at 22-24 Celsius; corresponding to the following external morphological criteria: N. olfactorius still longer than bulbus olfactorius. Guanophores appearing on lower jaw (adult skin area). Openings of gill chambers still wide. Distal half of fingers of stretched forelimb extending beyond base of hindlimb; forelimb still situated behind level of heart. Adult skin area of base of forelimb covered with guanophores; anterior border of adult skin area on abdomen sharper, reaching up to heart." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000071 ! NF stage 59 (Xenopus) [Term] id: XAO:1000073 name: NF stage 61 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 61; age about 48 days at 22-24 Celsius; corresponding to the following external morphological criteria: Head narrower. Tentacles considerably shortened, mostly curved backwards. Length of n. olfactorius equal to diameter of bulbus olfactorius. 4th arterial arch seen just in front of adult skin area of forelimb. Openings of gill chambers considerably narrowed. Forelimb at level of posterior half of heart. Adult skin area on abdomen covering posterior half of heart. Fins considerably reduced." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000072 ! NF stage 60 (Xenopus) [Term] id: XAO:1000074 name: NF stage 62 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 62; age about 49 days at 22-24 Celsius; corresponding to the following external morphological criteria: Head still somewhat broader than cranial part of trunk. Tentacles short, straight. N. olfactorius shorter than diameter of bulbus olfactorius. Corner of mouth still in front of eye. Thymus gland somewhat protruding. 3rd arterial arch (\"larval aorta\") seen at distance of its own diameter in front of adult skin area of forelimb. Opening of operculum reduced to curved slit. Forelimb at level of middle of heart. Anterior border of adult skin area on abdomen entirely sharp, mostly nicked medially. Ventral fin disappeared from abdomen." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000073 ! NF stage 61 (Xenopus) [Term] id: XAO:1000075 name: NF stage 63 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 63; age about 51 days at 22-24 Celsius; corresponding to the following external morphological criteria: Head narrower than trunk. Tentacles mostly disappeared. Corner of mouth at level of caudal border of eye. \"Larval aorta\" and thymus gland no longer externally visible. Operculum closed. Adult skin areas on abdomen and lower jaw separated by narrow band of larval skin. Forelimb at level of anterior half of heart. Fin mostly perforated near anus. Tail still slightly longer than body." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000074 ! NF stage 62 (Xenopus) [Term] id: XAO:1000076 name: NF stage 64 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 64; age about 53 days at 22-24 Celsius; corresponding to the following external morphological criteria: Corner of mouth well behind eye. Various adult skin areas joined almost everywhere, borderlines still clearly visible. Length of tail (from anus) is a third of body length." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000075 ! NF stage 63 (Xenopus) [Term] id: XAO:1000077 name: NF stage 65 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 65; age about 54 days at 22-24 Celsius; corresponding to the following external morphological criteria: Borderlines between adult skin areas partly disappeared. Tail oblong triangular in dorsal aspect, length abouth one tenth of body length." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000076 ! NF stage 64 (Xenopus) [Term] id: XAO:1000078 name: NF stage 66 (Xenopus) namespace: xenopus_developmental_stage def: "Nieuwkoop and Faber stage 66; age about 58 days at 22-24 Celsius; corresponding to the following external morphological criteria: Border lines between adult skin areas disappeared. Tail only a very small triangle, no longer visible from ventral side." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000091 ! climax (Xenopus) relationship: preceded_by XAO:1000077 ! NF stage 65 (Xenopus) [Term] id: XAO:1000079 name: metamorphosing tadpole (Xenopus) namespace: xenopus_developmental_stage def: "The stages from Nieuwkoop and Faber stage 54 to stage 66." [ISBN:0815318960] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0004728 ! amphibian larval stage [Term] id: XAO:1000080 name: late tailbud (Xenopus) namespace: xenopus_developmental_stage def: "The stages from Nieuwkoop and Faber stage 29/30 to stage 44." [ISBN:0815318960] is_a: UBERON:0009741 ! tailbud stage [Term] id: XAO:1000081 name: unspecified stage (Xenopus) namespace: xenopus_developmental_stage is_a: UBERON:0000105 ! life cycle stage [Term] id: XAO:1000082 name: unfertilized egg (Xenopus) namespace: xenopus_developmental_stage def: "Any of the developmental stages corresponding to the developing and mature female germ cells." [XAO:EJS] is_a: UBERON:0000105 ! life cycle stage [Term] id: XAO:1000083 name: oocyte stage I (Xenopus) namespace: xenopus_developmental_stage def: "Developmental stage corresponding to the developing female gamete of the pre-vitellogenic stage." [XAO:EJS] is_a: XAO:1000082 ! unfertilized egg (Xenopus) [Term] id: XAO:1000084 name: oocyte stage II (Xenopus) namespace: xenopus_developmental_stage def: "Developmental stage corresponding to the developing female gamete of the early vitellogenic stage." [XAO:EJS] is_a: XAO:1000082 ! unfertilized egg (Xenopus) relationship: preceded_by XAO:1000083 ! oocyte stage I (Xenopus) [Term] id: XAO:1000085 name: oocyte stage III (Xenopus) namespace: xenopus_developmental_stage def: "Developmental stage corresponding to the developing female gamete of the mid-vitellogenic stage." [XAO:EJS] is_a: XAO:1000082 ! unfertilized egg (Xenopus) relationship: preceded_by XAO:1000084 ! oocyte stage II (Xenopus) [Term] id: XAO:1000086 name: oocyte stage IV (Xenopus) namespace: xenopus_developmental_stage def: "Developmental stage corresponding to establishment of polarization along the animal-vegetal axis in the developing female gamete." [XAO:EJS] is_a: XAO:1000082 ! unfertilized egg (Xenopus) relationship: preceded_by XAO:1000085 ! oocyte stage III (Xenopus) [Term] id: XAO:1000087 name: oocyte stage V (Xenopus) namespace: xenopus_developmental_stage def: "Developmental stage corresponding to the developing female gamete of the late-vitellogenic stage." [XAO:EJS] is_a: XAO:1000082 ! unfertilized egg (Xenopus) relationship: preceded_by XAO:1000086 ! oocyte stage IV (Xenopus) [Term] id: XAO:1000088 name: oocyte stage VI (Xenopus) namespace: xenopus_developmental_stage def: "Developmental stage corresponding to the fully grown female gamete." [XAO:EJS] is_a: XAO:1000082 ! unfertilized egg (Xenopus) relationship: preceded_by XAO:1000087 ! oocyte stage V (Xenopus) [Term] id: XAO:1000089 name: premetamorphosis (Xenopus) namespace: xenopus_developmental_stage def: "The period during which limb bud growth occurs, covering Nieuwkoop and Faber stage 45 to stage 54." [ISBN:0124554032] is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0004728 ! amphibian larval stage [Term] id: XAO:1000090 name: prometamorphosis (Xenopus) namespace: xenopus_developmental_stage def: "The period during which toe differentiation and rapid hind limb growth continue, covering Nieuwkoop and Faber stage 55 to stage 57." [ISBN:0124554032] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000079 ! metamorphosing tadpole (Xenopus) [Term] id: XAO:1000091 name: climax (Xenopus) namespace: xenopus_developmental_stage def: "The period during which tail resorption occurs, covering Nieuwkoop and Faber stage 58 to stage 66." [ISBN:0124554032] is_a: UBERON:0000105 ! life cycle stage relationship: part_of XAO:1000079 ! metamorphosing tadpole (Xenopus) [Term] id: XAO:1000092 name: mature egg (Xenopus) namespace: xenopus_developmental_stage def: "Developmental stage corresponding to the mature female germ cell." [XAO:EJS] is_a: XAO:1000082 ! unfertilized egg (Xenopus) relationship: preceded_by XAO:1000088 ! oocyte stage VI (Xenopus) [Term] id: XAO:1000093 name: adult frog (Xenopus) namespace: xenopus_developmental_stage def: "The stage of being a fully formed animal." [XAO:curator] is_a: UBERON:0000105 ! life cycle stage relationship: preceded_by UBERON:0000112 ! juvenile stage [Term] id: ZFS:0000005 name: Cleavage:16-cell namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-20 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by UBERON:0007236 ! 8 cell stage relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: ZFS:0000006 name: Cleavage:32-cell namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-25 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000005 ! Cleavage:16-cell relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: ZFS:0000007 name: Cleavage:64-cell namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-28 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000006 ! Cleavage:32-cell relationship: part_of UBERON:0000107 ! cleavage stage [Term] id: ZFS:0000008 name: Blastula:128-cell namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-7 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000007 ! Cleavage:64-cell relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000009 name: Blastula:256-cell namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-1 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000008 ! Blastula:128-cell relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000010 name: Blastula:512-cell namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-14 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000009 ! Blastula:256-cell relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000011 name: Blastula:1k-cell namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-22 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000010 ! Blastula:512-cell relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000012 name: Blastula:High namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-27 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000011 ! Blastula:1k-cell relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000013 name: Blastula:Oblong namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-24 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000012 ! Blastula:High relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000014 name: Blastula:Sphere namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-21 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000013 ! Blastula:Oblong relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000015 name: Blastula:Dome namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-19 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000014 ! Blastula:Sphere relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000016 name: Blastula:30%-epiboly namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-17 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000015 ! Blastula:Dome relationship: part_of UBERON:0000108 ! blastula stage [Term] id: ZFS:0000017 name: Gastrula:50%-epiboly namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-6 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000016 ! Blastula:30%-epiboly relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: ZFS:0000018 name: Gastrula:Germ-ring namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-3 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000017 ! Gastrula:50%-epiboly relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: ZFS:0000019 name: Gastrula:Shield namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-2 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000018 ! Gastrula:Germ-ring relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: ZFS:0000020 name: Gastrula:75%-epiboly namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-18 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000019 ! Gastrula:Shield relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: ZFS:0000021 name: Gastrula:90%-epiboly namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-29 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000020 ! Gastrula:75%-epiboly relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: ZFS:0000022 name: Gastrula:Bud namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-12 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000021 ! Gastrula:90%-epiboly relationship: part_of UBERON:0000109 ! gastrula stage [Term] id: ZFS:0000023 name: Segmentation:1-4 somites namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-23 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000022 ! Gastrula:Bud [Term] id: ZFS:0000024 name: Segmentation:5-9 somites namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-5 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000023 ! Segmentation:1-4 somites [Term] id: ZFS:0000025 name: Segmentation:10-13 somites namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-020626-1 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000024 ! Segmentation:5-9 somites [Term] id: ZFS:0000026 name: Segmentation:14-19 somites namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-30 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000025 ! Segmentation:10-13 somites [Term] id: ZFS:0000027 name: Segmentation:20-25 somites namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-16 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000026 ! Segmentation:14-19 somites [Term] id: ZFS:0000028 name: Segmentation:26+ somites namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-34 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000027 ! Segmentation:20-25 somites [Term] id: ZFS:0000029 name: Pharyngula:Prim-5 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-10 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000028 ! Segmentation:26+ somites relationship: part_of UBERON:0004707 ! pharyngula stage [Term] id: ZFS:0000030 name: Pharyngula:Prim-15 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-32 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000029 ! Pharyngula:Prim-5 relationship: part_of UBERON:0004707 ! pharyngula stage [Term] id: ZFS:0000031 name: Pharyngula:Prim-25 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-13 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000030 ! Pharyngula:Prim-15 relationship: part_of UBERON:0004707 ! pharyngula stage [Term] id: ZFS:0000032 name: Pharyngula:High-pec namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-31 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000031 ! Pharyngula:Prim-25 relationship: part_of UBERON:0004707 ! pharyngula stage [Term] id: ZFS:0000033 name: Hatching:Long-pec namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-9 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000032 ! Pharyngula:High-pec relationship: part_of UBERON:0004707 ! pharyngula stage [Term] id: ZFS:0000034 name: Hatching:Pec-fin namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-26 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000033 ! Hatching:Long-pec relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000035 name: Larval:Protruding-mouth namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-8 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000034 ! Hatching:Pec-fin relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000036 name: Larval:Day 4 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-35 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000035 ! Larval:Protruding-mouth relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000037 name: Larval:Day 5 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-36 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000036 ! Larval:Day 4 relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000038 name: Larval:Day 6 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-37 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000037 ! Larval:Day 5 relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000039 name: Larval:Days 7-13 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-47 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000038 ! Larval:Day 6 relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000040 name: Larval:Days 14-20 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-48 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000039 ! Larval:Days 7-13 relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000041 name: Larval:Days 21-29 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-49 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000040 ! Larval:Days 14-20 relationship: part_of UBERON:0000069 ! larval stage [Term] id: ZFS:0000042 name: Juvenile:Days 30-44 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-51 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000041 ! Larval:Days 21-29 relationship: part_of UBERON:0000112 ! juvenile stage [Term] id: ZFS:0000043 name: Juvenile:Days 45-89 namespace: zebrafish_stages xref: ZFIN:ZDB-STAGE-010723-52 is_a: UBERON:0000105 ! life cycle stage relationship: immediately_preceded_by ZFS:0000042 ! Juvenile:Days 30-44 relationship: part_of UBERON:0000112 ! juvenile stage [Typedef] id: BFO:0000051 inverse_of: part_of [Typedef] id: finishes is_a: part_of [Typedef] id: immediately_preceded_by is_a: preceded_by [Typedef] id: part_of is_transitive: true [Typedef] id: preceded_by is_transitive: true [Typedef] id: starts is_a: part_of